Genome ID：GCA_021991685.1

Probiotic potential risk score

ARGs (CARD)	VFs (VFDB)	PGs (PHI-base)	PPRS
20	43	277	281.03

CARD

ARO accession	ARO name	Identity	Coverage	CARD name	Accession no.
ARO:3000412	sul2	100.00	100.00	sul2	AY055428.1
ARO:3000873	TEM-1	100.00	100.00	TEM-1	AL513383.1
ARO:3000518	CRP	99.05	100.00	CRP	AP009048.1
ARO:3000828	baeR	96.65	100.42	baeR	AP009048.1
ARO:3003950	msbA	94.16	100.00	msbA	U00096.3
ARO:3002986	bacA	93.77	99.63	bacA	U00096.3
ARO:3003890	Escherichia coli UhpT with mutation conferring resistance to fosfomycin	93.74	100.00	Ecol_UhpT_FOF	HG738867.1
ARO:3000263	marA	93.70	100.00	marA	AP009048.1
ARO:3000516	emrR	93.14	100.00	emrR	U00096.3
ARO:3000074	emrB	93.07	100.59	emrB	U00096.1
ARO:3000216	acrB	92.54	99.71	acrB	U00096.3
ARO:3000491	acrD	92.46	100.00	acrD	AP009048.1
ARO:3000794	mdtC	91.89	100.00	mdtC	U00096.1
ARO:3000793	mdtB	90.09	100.10	mdtB	U00096.1
ARO:3004583	Klebsiella pneumoniae KpnF	87.16	100.00	Kpne_KpnF	AP006725.1
ARO:3001328	Escherichia coli mdfA	86.49	100.24	Ecol_mdfA	JQ394987.1
ARO:3003378	Escherichia coli AcrAB-TolC with MarR mutations conferring resistance to ciprofloxacin and tetracycline	86.11	100.00	Ecol_MarR_MULT	U00096.1
ARO:3005069	rsmA	85.25	100.00	rsmA	AF061757.1
ARO:3003807	Escherichia coli AcrAB-TolC with AcrR mutation conferring resistance to ciprofloxacin, tetracycline, and ceftazidime	84.21	100.93	Ecol_AcrR_MULT	U00096.3
ARO:3004580	Klebsiella pneumoniae KpnE	82.50	100.00	Kpne_KpnE	AP006725.1

Virulence Factor Database Search

Gene ID	Gene name	Identity	Coverage	e-value	VF name	VF category	Accession no.
VFG048680	hcp/tssD	90.41	98.99	0.0	T6SS	Effector delivery system	-
VFG048782	sciN/tssJ	89.89	99.63	0.0	T6SS	Effector delivery system	WP_038423150
VFG048700	vgrG/tssI	89.79	71.49	0.0	T6SS	Effector delivery system	WP_014838709
VFG000477	rpoS	89.43	99.80	0.0	RpoS	Regulation	NP_461845
VFG048764	tssF	89.36	99.83	0.0	T6SS	Effector delivery system	WP_014838697
VFG043057	fliG	88.43	99.80	0.0	Peritrichous flagella	Motility	NP_460923
VFG048646	vasE/tssK	87.62	100.00	0.0	T6SS	Effector delivery system	WP_014838714
VFG048748	icmF/tssM	87.26	88.56	0.0	T6SS	Effector delivery system	WP_014838699
VFG043049	fliA	86.67	100.00	0.0	Peritrichous flagella	Motility	NP_460909
VFG048657	dotU/tssL	86.58	100.14	0.0	T6SS	Effector delivery system	WP_014838713
VFG049013	rcsB	86.37	99.69	0.0	RcsAB	Regulation	WP_004201684
VFG049146	acrB	86.03	98.35	0.0	AcrAB	Antimicrobial activity/Competitive advantage	WP_012968813
VFG043544	ompA	85.91	99.62	0.0	Z1307	Adherence	WP_000750416
VFG043027	flgG	85.84	99.87	0.0	Peritrichous flagella	Motility	NP_460150
VFG049194	clpV	85.72	99.88	0.0	T6SS-II	Effector delivery system	WP_004150973
VFG043038	cheB	85.70	99.71	0.0	Peritrichous flagella	Motility	NP_460874
VFG048415	entB	85.47	99.41	0.0	Ent	Nutritional/Metabolic factor	YP_005225748
VFG048773	tssG	84.81	100.00	0.0	T6SS	Effector delivery system	WP_014229647
VFG048968	gndA	84.73	99.93	0.0	Capsule	Immune modulation	WP_012541090
VFG048480	fepC	84.64	95.97	0.0	Ent	Nutritional/Metabolic factor	WP_014837773
VFG043114	fliM	84.62	99.90	0.0	Peritrichous flagella	Motility	WP_010904778
VFG048464	fepD	83.69	84.13	0.0	Ent	Nutritional/Metabolic factor	WP_012542490
VFG048510	fepA	83.03	90.09	0.0	Ent	Nutritional/Metabolic factor	WP_014837769
VFG048473	fepG	82.87	85.80	0.0	Ent	Nutritional/Metabolic factor	WP_004147521
VFG043099	tcyJ	82.81	95.88	0.0	Peritrichous flagella	Motility	WP_001302033
VFG048405	entA	82.24	97.88	0.0	Ent	Nutritional/Metabolic factor	YP_005225749
VFG043039	cheR	82.07	99.65	0.0	Peritrichous flagella	Motility	NP_460875
VFG043110	fliI	81.50	99.34	0.0	Peritrichous flagella	Motility	WP_000213294
VFG048460	entS	81.10	90.58	0.0	Ent	Nutritional/Metabolic factor	WP_008805583
VFG043086	flhA	81.00	98.46	0.0	Peritrichous flagella	Motility	WP_000067016
VFG049125	acrA	80.89	99.66	0.0	AcrAB	Antimicrobial activity/Competitive advantage	WP_004136054
VFG048692	clpV/tssH	80.73	97.33	0.0	T6SS	Effector delivery system	WP_012541980
VFG048974	galF	80.62	96.88	0.0	Capsule	Immune modulation	WP_016946203
VFG048430	entE	80.60	97.39	0.0	Ent	Nutritional/Metabolic factor	WP_012968726
VFG048970	ugd	80.56	96.92	0.0	Capsule	Immune modulation	WP_004175261
VFG043036	cheZ	83.86	98.29	7.07e-173	Peritrichous flagella	Motility	NP_460872
VFG043117	fliP	83.62	86.04	3.78e-171	Peritrichous flagella	Motility	WP_001253441
VFG043080	flgH	82.84	91.42	6.02e-164	Peritrichous flagella	Motility	WP_001295442
VFG043045	flhC	84.19	98.97	3.90e-160	Peritrichous flagella	Motility	NP_460881
VFG043064	fliN	85.30	99.76	2.88e-120	Peritrichous flagella	Motility	NP_460930
VFG048627	vipA/tssB	82.15	99.80	1.60e-118	T6SS	Effector delivery system	WP_012541985
VFG043089	cheY	83.85	100.00	3.58e-104	Peritrichous flagella	Motility	WP_000763867
VFG043048	fliZ	80.25	86.23	1.44e-99	Peritrichous flagella	Motility	NP_460908

PHIB-BLAST

Protein ID	Gene name	Identity	Coverage	e-value	Function	Gene ID
P60651	speB	99.02	99.67	0.0	Agmatinase	AAC75974
P0DM81	rpoS	98.48	99.70	0.0	Regulators of systemic infection	RPOS_SALTY
A0A0F6AXS9	lon	97.83	99.87	0.0	ATP-dependent protease	ACY87051
P0A2P8	fruR	97.61	99.70	0.0	Regulators of systemic infection	CRA_SALTY
P0A9E5	FNR	97.20	99.60	0.0	global regulator	AAA87981
Q7CPB9	oxyR	96.72	99.67	0.0	Regulatory protein sensor for oxidative stress	AAL22963
C3T127	ptsI	96.35	99.83	0.0	Phosphoenolpyruvate-protein phosphotransferase	ACI80411
A0A0D6I2I2	spoT	96.30	99.86	0.0	(P)ppGpp synthetase	AKH09371
D2TU77	cpxA	96.28	99.78	0.0	Two-component sensor kinase	CBG90543
P0AC41	sdhA	96.26	99.83	0.0	Succinate dehydrogenase �avoprotein subunit	AAA23895
Q8ZLT3	pnp	96.06	99.86	0.0	polynucleotide phosphorylase, an exoribonuclease involved in RNA processing and degradation	AAL22154
P04042	cheB	95.99	99.71	0.0	Chemotaxis	AAL20833
A0A164J6A6	rarA	95.97	99.78	0.0	Holliday junction DNA helicase	SAS94147
P0A1P6	glnA	95.74	99.79	0.0	Glutamine synthetase	AAL22846
P75825	hcp	95.64	99.82	0.0	Hydroxylamine reductase	AAC73960
P08982	envZ	95.51	98.67	0.0	Regulators of systemic infection	ENVZ_SALTY
D2TPE2	tolB	95.35	99.77	0.0	Colicin import protein	CBG87511
A0A0F6B5R3	STM14_RS15285	95.08	99.82	0.0	Formate hydrogenlyase subunit 4	ACY89857
P09152	narG	94.79	99.92	0.0	Respiratory nitrate reductase 1 alpha chain	CAA34303
A0A0F6B0W4	sufB	94.55	99.80	0.0	Sulfur mobilization	ACY88142
A0A0H3N916	AcrB	94.54	99.43	0.0	Efflux pump membrane transporter	CBW16569
B5QZL1	prt	94.31	99.67	0.0	OAg biosynthesis	CAR33649
A0A0W8AWM7	yhbU	94.26	99.70	0.0	Ubiquinone biosynthesis protein	ARA47379
P40729	flhA	94.22	99.86	0.0	Flagellar biosynthesis protein	AAL20829
W9BCN0	leuB	94.22	99.73	0.0	3-Isopropylmalate dehydrogenase	AIT01852
P65882	purA	94.21	99.77	0.0	Pathogenicity island	AAL23186
B5Y1W2	leuA	94.07	99.81	0.0	2-Isopropylmalate synthase	ACI08908
W9BBU8	leuC	93.99	99.79	0.0	3-Isopropylmalate dehydratase large subunit	AIT01851
A0A076ZPI5	VK055_1939	93.92	99.72	0.0	Branched-chain amino acid transport system/permease component family protein	AIK80545
C3T032	ppk1	93.46	99.71	0.0	Polyphosphate kinase 1	ACI80066
Q8ZJY5	yjiY	93.44	99.86	0.0	Peptide-utilizing carbon starvation protein	AAL23350
A0A076ZPI8	VK055_1944	93.31	99.78	0.0	L-Fucose isomerase, C-terminal domain protein	AIK80550
P40720	fumA	93.24	94.15	0.0	Fumarate hydratase class I, aerobic	AAL20388
D4HYB2	guaB	93.03	99.80	0.0	Inosine-5'-monophosphate dehydrogenase	CBA21987
Q8ZR28	cstA	93.01	99.86	0.0	Peptide-utilizing carbon starvation protein	AAL19551
P0A853	tnaA	92.99	99.79	0.0	Tryptophanase	AAA24676
A0A0F6B5Q1	STM14_RS15240	92.95	100.21	0.0	NADH:flavorubredoxin reductase	ACY89845
P0A7F6	speD	92.80	99.62	0.0	S-adenosylmethionine decarboxylase proenzyme	AAC73231
Q8ZME2	relA	92.76	99.87	0.0	(P)ppGpp synthetase I	AAL21836
P09158	speE	92.58	97.92	0.0	Polyamine aminopropyltransferase	AAC73232
P11349	narH	92.56	99.42	0.0	Respiratory nitrate reductase 1 beta chain	CAA34304
P09348	motA	92.54	99.66	0.0	Motility protein	AAA24177
P27550	acs	92.48	99.85	0.0	Acetyl-coenzyme A synthetase	AAC43163
A0A8E5JM30	acrD	92.27	99.71	0.0	Resistance-nodulation-cell division (RND) transporter	QUZ94265
P32705	actP	92.17	99.82	0.0	Acetate/glycolate:cation symporter	AAC77037
D2TI55	map	92.02	99.25	0.0	Effector protein	CBG86951
P05416	glgA	91.81	99.58	0.0	Glycogen synthase	AAL22395
P07801	cheR	91.67	99.65	0.0	Chemotaxis protein methyltransferase	AAL20834
A0A0F6B941	atpB	91.51	99.63	0.0	F0F1 ATP synthase subunit A	ACY91043
P0A9G2	nhaR	91.28	98.68	0.0	Transcriptional activator protein	CAA27969
P63883	amiC	91.21	95.22	0.0	N-acetylmuramoyl-L-alanine amidase	AAC75856
P24183	fdnG	91.03	79.04	0.0	Formate dehydrogenase, nitrate-inducible, major subunit	AAD13438
B5XY48	OmpA2	90.88	99.72	0.0	outer membrane proteins	ACI08342
P19318	narY	90.66	99.81	0.0	Respiratory nitrate reductase 2 beta chain	AAC74549
B5F8I0	ArgD	90.59	99.51	0.0	Acetylornithine/succinyldiaminopimelate aminotransferase	ACH49836
P36548	amiA	90.38	99.66	0.0	N-acetylmuramoyl-L-alanine amidase	AAC75488
D4I3E6	trpB	90.38	99.50	0.0	Tryptophan synthase beta chain	CBA20869
D4HUC7	pfkA	90.31	99.69	0.0	ATP-dependent 6-phosphofructokinase	CBA19050
Q8ZPL7	fumC	90.28	98.93	0.0	Fumarate hydratase class II	AAL20389
A0A086IQC3	proV	90.25	99.75	0.0	Glycine betaine/L-proline transport ATP-binding protein	AIS99989
P32176	fdoG	90.17	79.06	0.0	Formate dehydrogenase-O major subunit	AAB03027
W8ZK20	yegN	90.09	99.81	0.0	Multidrug efflux system subunit	CDN82752
P23865	Prc	90.03	99.85	0.0	Tail-specific protease	BAA00577
A0A380PIP1	bipA	89.77	99.67	0.0	Putative GTPase	CAL18716
P0AB24	efeO	89.60	99.73	0.0	Iron uptake system component	AAC74103
A7ZRQ3	sufI	89.57	99.79	0.0	Cell division protein	ABV16661
A0A0D6I3U0	envC	89.46	99.77	0.0	Determinants for intrinsic CAMP resistance	ALE64165
P0A6Z3	htpG	89.42	99.84	0.0	heat shock protein 90 chaperone	AAA23460
P19319	narZ	89.08	99.92	0.0	Respiratory nitrate reductase 2 alpha chain	AAC74550
E1AP33	corA	88.92	99.68	0.0	Magnesium/nickel/cobalt transporter	HM852064
D4HXG4	purF	88.91	99.80	0.0	Amidophosphoribosyltransferase	CBA21663
P30745	moaA	88.75	99.70	0.0	GTP 3',8-cyclase	AAC73868
A0A0H3NBW6	katN	88.58	98.63	0.0	Catalase	CBW17757
P19642	pafP	88.49	99.81	0.0	Transcription Regulator	AAA24098
P0A6T3	galK	88.48	99.74	0.0	Galactokinase	CAA26172
P07637	aroA	88.29	99.77	0.0	Pathogenicity island	AAA27028
Q8ZMX2	pat	88.18	99.21	0.0	acetyltransferase	AAL21545
C5BEV2	glyA	87.53	99.76	0.0	Serine h ydroxymethyltra nsferase	ACR70340
D4HUF7	metB	87.53	99.48	0.0	Cystathionine gamma-synthase	CBA19080
D4HYW4	asnB	87.18	99.64	0.0	Asparagine synthase B	CBA20089
D4HUG0	metF	87.16	98.01	0.0	Methylenetetrahydrofolate reductase	CBA19083
P08331	cpdB	87.02	99.85	0.0	2_,3_-Cyclic phosphodiesterase	AAA97109
W9BNM8	entB	86.93	99.30	0.0	Enterobactin and salmochelin	ANN51031
A0A0F6B5P9	STM14_RS15230	86.92	99.69	0.0	NorR family transcriptional regulator	ACY89843
P17750	katG	86.76	99.59	0.0	Catalase	AAL22946
P33221	purT	86.73	99.75	0.0	Formate-dependent phosphoribosylglycinamide formyltransferase	AAA23861
D4ICB6	nlpI	86.73	99.66	0.0	Tetratricopeptide lipoprotein	EAM_3066
P40120	mdoD	86.73	99.64	0.0	Glucans biosynthesis protein D	AAC74506
P21169	speC	86.72	99.44	0.0	Constitutive ornithine decarboxylase	AAC76002
C6DC70	clpB	86.70	99.88	0.0	Chaperone protein	ACT14164
Q66A26	pykF	86.47	100.21	0.0	Part of the pyruvate - tricarboxylic acid cycle node	CAH21544
Q8ZNK8	yeiE	86.46	99.65	0.0	Putative LysR family transcriptional regulator	AAL21105
Q54001	MdsABC	86.41	95.53	0.0	Multidrug transporter of Salmonella	TOLC_SALEN
A0A0F6B5Q0	STM14_RS15235	86.19	99.61	0.0	Anaerobic nitric oxide reductase flavorubredoxin	ACY89844
P0AF06	motB	86.08	99.68	0.0	Motility protein	AAA24178
Q7CQF1	hnr	86.05	99.70	0.0	Regulators of systemic infection	Q7CQF1_SALTY
Q8Z445	barA	86.01	100.22	0.0		AAO70423
A0A0F6BB74	tsr	85.92	99.82	0.0	Methyl-accepting chemotaxis protein	ACY91777
D4HYF4	purL	85.48	99.92	0.0	Phosphoribosylformylglycinamidine synthase	CBA22070
D4HUI1	ilvA	85.41	99.81	0.0	Threonine dehydratase	CBA19104
Q8ZRE1	phoR	85.35	99.54	0.0	Histidine kinase	AAL19352
D4I4L2	glmS	85.22	99.84	0.0	Glucosamine-fructose-6-phosphateaminotransferase	CBA24212
Q9L7R4	yihO	85.08	98.73	0.0	O-Antigen Capsule	AF220438_7
D4I0H1	carA	85.08	97.45	0.0	Carbamoyl-phosphate synthase small chain	CBA22700
P36771	LrhA	84.94	99.68	0.0	Probable HTH-type transcriptional regulator	CAA52637
P58662	rcsC11	84.81	99.89	0.0	Sensor protein	AAL21172
C5BDL7	frdA	84.81	99.67	0.0	Fumarate reductase	ACR67633
D4HUM7	metE	84.75	99.34	0.0	5-Methyltetrahydropteroyltriglutamate-homocysteine methyltransferase	CBA19150
D4HUY5	rpoN	84.49	99.79	0.0	Sigma factor, regulating essential virulence gene expression	CBA19258
D4I2T4	metA	84.47	99.68	0.0	Homoserine O-succinyltransferase	CBA23513
P39172	znuA	84.39	100.64	0.0	Zn(2(+)) ABC transporter periplasmic binding	AAC74927
A0A5Z5IUY8	qseE	84.18	95.39	0.0	Two-component regulatory system protein	EBV8836849
D4HUM6	metR	84.09	98.40	0.0	HTH-type transcriptional regulator	CBA19149
H9L460	katE	84.04	100.00	0.0	Catalase	AAL20243
P76299	flhB	83.95	99.22	0.0	Flagellar biosynthetic protein	AAC74950
P31554	LptD	83.84	99.75	0.0	LPS-assembly protein	BAA34130
P25535	ubiI	83.75	99.75	0.0	Aerobic ubiquinone-8 synthase	BAA14327
D4I2T0	pgi	83.58	99.82	0.0	Glucose-6-phosphate isomerase	CBA23505
A0A076ZK37	VK055_1980	83.48	99.66	0.0	HADa ATPase, P type	AIK80586
D4HWM2	cysI3	83.13	99.48	0.0	Sulfite reductase	CBA19698
P31545	efeB	83.06	100.00	0.0	Deferrochelatase/peroxidase	AAC74104
D4HUG1	ppc	82.79	99.89	0.0	Phosphoenolpyruvate carboxylase	CBA19084
C5BF98	mdh	82.69	99.68	0.0	Malate dehydrogenase	ACR67684
C9XTL6	rpfF	82.64	99.31	0.0	RpfFBc/RpfR system is involved in sensing and responding to DSF signals	CBA31267
A0A0F6B1Q1	trg	82.56	99.45	0.0	Methyl-accepting chemotaxis protein	ACY88437
P37596	norW	82.49	99.74	0.0	NO reductase	BAA05934
Q8ZQE4	MacB	82.44	99.69	0.0	ABC-Type Ef�ux Pump	AAL19878
C9XTL5	rpfR	82.37	96.06	0.0	RpfFBc/RpfR system is involved in sensing and responding to DSF signals	CBA31265
Q8ZJN0	pgm	82.14	99.81	0.0	2,3-Bisphosphoglycerate-independent phosphoglycerate mutase	CAL18753
P07363	cheA	81.78	102.44	0.0	Chemotaxis protein	AAA23573
P77554	yahJ	81.78	99.78	0.0	Putative deaminase with metallo-dependent hydrolase domain	AAC73427
A0A0F6B1M0	ydcR	81.74	99.16	0.0	Putative transcriptional regulator	ACY88406
Q48473	ompK36	81.60	101.37	0.0	Outer membrane protein	CAA83913
P76142	lsrB	81.55	98.24	0.0	Autoinducer-2 ABC transporter periplasmic binding protein	AAC74589
P26469	rfaC	81.45	99.06	0.0	heptosyl transferase	AAL22571
B5XSN9	phoQ	81.29	98.16	0.0	govern the expression of cps and of the loci implicated in lipid A remodeling	ACI11151
E8XCP9	MacA	81.08	98.93	0.0	ABC-Type Ef�ux Pump	ADX1663
P36649	cueO	81.04	99.81	0.0	Blue copper oxidase	AAC73234
A0A0F6B5P8	STM14_RS15225	89.11	99.61	1.00e-177	Arabinose 5-phosphate isomerase	ACY89842
P0AA16	ompR	100.00	99.58	1.02e-177	Transcriptional regulator	AAC76430
D0ZX10	sssB	82.33	100.32	1.61e-175	Secreted effector protein	ACY88258
P07014	sdhB	94.96	99.58	2.51e-175	Succinate dehydrogenase iron-sulfur subunit	AAA23896
P0A9Q1	arcA	97.06	99.58	4.64e-175	Aerobic respiration control protein	AAA97297
P0AC26	NirC	89.22	99.63	6.02e-175	Nitrite transporter	CAA32418
A0A0F6B5R4	STM14_RS15290	84.04	99.68	1.33e-174	Formate hydrogenlyase subunit 3	ACY89858
A0A0F6B5S1	STM14_RS15315	82.41	99.66	1.40e-174	Hydrogenase assembly chaperone	ACY89865
D2TR63	artP	94.22	99.59	2.94e-174	Arginine ABC transporter, ATP-binding protein	CBG87650
P39832	znuB	93.49	99.62	1.23e-173	Zn(2(+)) ABC transporter membrane subunit	AAC74929
A0A0M2J080	sufC	93.14	99.60	1.94e-173	Sulfur mobilization	APF09033
P0A2F2	cob	88.17	95.62	3.91e-170	nicotinamide adenine dinucleotide (NAD + )-dependent deacetylase	AAC78722
U6ZHA8	kdgR	88.59	99.62	1.38e-169	virulence negative regulators	ERO57666
Q9L7R1	yihW	86.43	96.27	1.47e-169	O-Antigen Capsule	AF220439_2
P0A9X1	znuC	91.23	99.60	2.43e-169	Zn(2(+)) ABC transporter ATP binding subunit	AAC74928
D0ZRW0	sseB	87.60	98.47	4.15e-169	Secreted effector protein	ACY89541
C6DEY6	rsmA	80.88	99.63	1.88e-167	Ribosomal RNA small subunit methyltransferase A	ACT14650
A0A0F6B5R1	STM14_RS15275	85.04	99.22	5.16e-166	Formate hydrogenlyase complex iron-sulfur subunit	ACY89855
Q7CPD5	tatC	90.87	92.69	2.63e-162	Sec-independent protein translocase	AAL22819
A6TAW6	gntR	88.70	99.58	9.62e-162	Fatty acid metabolism regulator	ABR77737
A0A518VKX7	kduD	82.61	99.61	1.89e-161	2-Dehydro-3-deoxy-D-gluconate 5-dehydrogenase	QHP58461
P0A2T6	crp	100.00	99.53	1.84e-159	Regulators of systemic infection	CRP_SALTY
P23836	phoP	94.17	99.55	6.75e-158	Transcriptional regulatory protein	BAA14390
C4PCU2	rcsB	99.07	99.54	5.66e-157	RcsA and RcsB form a complex to promote transcription of the genes for capsule synthesis.	ACQ91082
P0A1D7	ClpP	99.03	99.52	1.02e-156	proteolytic component	BAA94668
D2TU76	cpxR	95.69	99.57	6.75e-153	Two-component response regulator	CBG90542
Q66EI1	pdhR	85.83	99.61	5.64e-152	Part of the pyruvate - tricarboxylic acid cycle node	CAH19952
P43019	sodA	96.60	99.52	2.01e-151	Cytoplasmic superoxide dismutase	AAC43331
P11350	narI	87.50	99.12	6.42e-151	Respiratory nitrate reductase 1 gamma chain	AAC74311
C9Y236	FkpA	86.26	94.57	2.30e-149	virulence factor	CBA34185
P08870	pyrE	93.43	99.53	6.67e-149	Orotate phosphoribosyltransferase	AAL22592
A0A0F6B1X1	pspA	93.24	99.55	3.48e-148	Phage-shock protein	ACY88508
P0AF32	narV	86.28	99.56	9.44e-147	Respiratory nitrate reductase 2 gamma chain	BAA15102
P60317	ProQ	87.77	99.13	1.01e-146	RNA chaperone	AAL20761
A0A0H3NDI1	tsaA	94.00	99.50	1.47e-144	Peroxiredoxin	CBW16497
Q8Z8K9	entA	84.27	98.41	6.23e-144	2,3-Dihydro-2,3-dihydroxybenzoate dehydrogenase	AAO69872
W9BQ45	leuD	93.00	99.01	1.92e-141	3-Isopropylmalate dehydratase small subunit	AIT01850
Q8ZMF9	pimt	90.39	99.52	9.69e-141	Protein isoaspartate methyl transferase	AAL21806
P0A2F0	rpoE	97.91	99.48	1.20e-139	Regulators of systemic infection	RPOE_SALT
P0AF26	narJ	83.83	99.16	1.39e-139	Nitrate reductase molybdenum cofactor assembly chaperone	AAC74310
W9B383	dedA	91.82	99.55	1.38e-137	DedA family inner membrane protein	ARA47408
P0A251	ahpC	94.65	99.47	1.92e-137	Peroxiredoxin	AAL19559
P07800	cheZ	91.59	99.53	2.38e-136	Protein phosphatase/ chemotactic response protein	AAL20831
Q6D4B5	eda	86.32	99.07	4.50e-136	2-Keto-3-deoxy-6-phosphogluconate aldolase	CAG75378
P66796	QseB	84.02	99.55	6.71e-136	Two-component system response regulator	CAD03009
P08179	purN	83.41	99.06	4.00e-134	Phosphoribosylglycinamide formyltransferase	AAA83899
P64036	EF-P	93.08	99.47	1.67e-133	Elongation factor	AAL23157
P0A2F4	sodB	91.19	99.48	1.76e-133	Cytoplasmic superoxide dismutase	AAL20353
Q5KQZ9	magA	90.67	99.48	5.48e-130	Contributes to K1 capsular polysaccharide (CPS) biosynthesis	BAD86762
P54698	rcsA	83.09	99.52	2.83e-129	Positive regulator of capsular polysaccharide synthesis. RcsA and RcsB form a complex to promote transcription of the genes for capsule synthesis.	AAL20894
P0AB06	ycbK	92.31	99.45	2.99e-129	Peptidoglycan LD-endopeptidase	AAC74012
P0AFV4	MepS	88.36	99.47	3.46e-126	Peptidoglycan DD-endopeptidase/peptidoglycan LD-carboxypeptidase	AAC75236
P0ACR9	MprA	93.14	98.87	1.57e-122	Transcriptional repressor of an operon encoding the EmrAB efflux pump.	CAA38090
A1AEN2	LuxS	91.23	99.42	6.82e-121	controller in the Quorum sensing	ABJ02122
A0A0F7DI09	ppiB	96.34	99.39	6.58e-120	Peptidyl-prolyl cis-trans isomerase	ALD83591
A0A0D6I7L0	ppiA	94.74	99.48	1.26e-119	Peptidyl-prolyl cis-trans isomerase	ALD83590
D3VBH2	lrp	96.95	99.39	2.72e-117	Global Transcription Factor	CBJ89611
A0A0F6B5R6	STM14_RS15300	85.35	97.54	3.21e-116	Formate hydrogenlyase regulator	ACY89860
A0A0F6B5R2	STM14_RS15280	82.78	99.45	3.20e-115	Formate hydrogenlyase subunit 5	ACY89856
P0AC98	satP	86.77	99.47	8.11e-115	Succinate-acetate/proton symporter	AAC73121
Q7CQ10	iscR	96.34	98.79	1.53e-113	Fe-S cluster sensor	AAL21438
P96058	sirA	95.06	73.97	2.22e-113		AAO68606
P0A1G5	DksA	99.34	99.34	1.86e-111	Response Regulator	AAD01437
P0A964	cheW	93.41	99.40	1.01e-110	Chemotaxis protein	AAA23565
A0A0F6B5Q6	STM14_RS15255	80.66	99.45	1.27e-110	Hypothetical protein	ACY89850
P0A2G1	smpB	90.62	99.38	6.45e-110	Regulators of systemic infection	SSRP_SALTY
D2TNF0	argR	95.51	99.36	4.94e-109	Arginine repressor	CBG91281
P64281	greA	91.77	99.37	8.16e-109	Transcription elongation factor	AAL22169
A0A0H3NC59	yeaB	83.85	99.48	1.02e-108	RNA methyltransferase	CBW17849
Q8ZLJ2	greB	91.72	99.37	3.65e-106	Transcription elongation factor	AAL22365
Q7CQY3	fur	97.26	96.69	1.02e-105	Ferric uptake regulation protein	AAL19637
D4I230	hcp-2	82.82	99.39	4.36e-104	T6SS Effector protein	CBA23273
Q665I9	ptsN	85.71	95.65	1.31e-96	Part of the pyruvate - tricarboxylic acid cycle node	CAH22766
A1JQ74	ybeY	83.23	98.10	9.27e-94	Endoribonuclease	CAL13026
Q57PB8	MarA	96.83	98.44	9.43e-92	Transcriptional regulator	AAX65443
A0A0L9JQ40	iscU	97.66	99.22	2.95e-91	Fe-S cluster sensor	APQ81541
Q8XBU9	ybdB	88.32	99.28	6.11e-90	Proofreading thioesterase	AE005239_7
P0A917	OmpX	80.35	99.42	1.10e-89	Outer membrane protein	AAA66329
P40676	slyA	87.50	99.31	4.88e-89	Regulators of systemic infection	SLYA_SALTY
P0A2D5	cheY	93.80	99.23	7.30e-87	Chemotaxis regulator protein	AAL20832
A0A0F6B5Q9	STM14_RS15265	80.13	96.18	5.50e-86	Formate hydrogenlyase maturation protein	ACY89853
A0A0F7J4C9	tomB	92.50	96.00	1.93e-84	Hha toxicity attenuator	AKH06147
P0A1K1	filj	81.63	99.32	3.07e-84	Flagellar protein	AAA27102
P69054	sdhC	89.92	99.23	5.04e-82	Succinate dehydrogenase	AAA23893
A0A0F6B5R0	STM14_RS15270	80.15	99.27	9.22e-81	NADH-quinone oxidoreductase subunit	ACY89854
P0ACF8	hns	91.97	99.28	3.66e-79	Global DNA-binding transcriptional dual regulator	CAA30530
Q57RZ3	ramA	86.73	99.12	5.47e-75	Transcriptional regulator	AAX64518
Q6CZA0	metJ	94.29	99.06	2.95e-74	Repressor of the methionine biosynthesis regulon	CAG77150
P0AC44	sdhD	90.44	99.14	3.00e-71	Succinate dehydrogenase	AAA23894
A0A0F6B5S6	STM14_RS15340	85.97	99.13	3.21e-71	Iron ABC transporter substrate-binding protein	ACY89870
P0A2R2	flhDC	85.34	100.88	4.79e-70	Regulatory protein	AAB96639
C6DIJ6	PccS1_001523	97.96	98.99	9.75e-68	Transcriptional regulator, Fis family, Fis	ACT11296
P0A1R0	hfq	95.15	98.06	2.69e-67	Regulators of systemic infection	HFQ_SALTY
A0A1C1TY69	mdtJ	82.50	99.17	3.20e-67	Multidrug transporter subunit	AUY17561
P64394	himD	97.87	98.95	6.39e-67	Regulators of systemic infection	IHFB_SALTY
D4HX89	yfiA	82.14	99.12	2.83e-66		CBA19780
B5XR94	mdtI	88.07	99.09	2.09e-65	Multidrug resistance protein	ACI10803
A0A0F7DJX4	ppiC	93.55	98.94	2.47e-61	Peptidyl-prolyl cis-trans isomerase	ALD83589
D0Z9U0	hupA	96.67	98.90	4.22e-59	Nucleoid-associated protein, is a basic DNA-binding protein involved in gene regulation	ACY83030
D4HUY4	yhbH	83.16	98.96	1.93e-56	a novel ribosome-associated modulation protein	CBA19257
D4HXP5	ptsH	95.29	98.84	1.09e-55	Phosphocarrier protein HPr	CBA21825
A0A0U1J4N7	yqiC	85.26	95.00	1.33e-55	Membrane fusogenic activity	CNQ39570
P0AA34	yedF	97.40	98.72	1.05e-52	Hypothetical transcription factor	AAL20878
Q8ZQ03	ycfR	89.41	98.84	3.16e-51	Outer membrane protein	AAL20143
Q7CR17	hha	94.44	98.63	7.56e-49	Hemolysin expression-modulating protein	AAL19427
A0A0F6B5S2	STM14_RS15320	80.00	97.80	7.57e-47	Hydrogenase formation protein	ACY89866
P0A9Y9	cspC	100.00	98.57	3.00e-46	Cold shock protein	AAC06037
A0A0F6AYC2	cspE	97.10	98.57	1.15e-45	Cold shock protein	ACY87244
A0A0F6B1X0	pspB	89.19	98.67	4.10e-45	Phage-shock protein	ACY88507
A0A0U1FZZ2	tatA	83.33	98.82	7.35e-45	Sec-independent protein translocase protein	CNR43436
P69913	csrA	100.00	98.39	5.66e-40	Post-transcriptional regulator	AAA71919
A0A6C7HPB2	SEN1538	85.97	93.44	5.60e-29	Conserved hypothetical protein	CAR33117
Q48412	RomA (VK055_1984)	81.13	79.70	3.47e-59	Metallo-beta-lactamase superfamily protein	AIK80590
D4I4J9	EaAdeP (EAMY 3685)	84.95	98.63	0.0	Putative AzgA family transporter	CBA24187
W9BF24	EntA (VK055_1922)	88.31	94.66	7.67e-153	2,3-Dihydro-2,3-dihydroxybenzoate dehydrogenase	AIK80528
Q9I0J4	nuoI (PA2644)	83.52	96.17	3.67e-109	NADH-quinone oxidoreductase	AE004693_3
A1JLB7	RcsB (YE1397)	91.91	97.22	1.95e-142	Transcriptional regulatory protein	CAL11489
A0A0F6B0X0	STM14_RS07735 (lppB)	84.81	97.50	7.77e-42	Hypothetical protein	ACY88148
W1B397	entS (VK055_1927)	85.16	98.56	0.0	Enterobactin exporter	AIK80533
A0A0F6B0X1	STM14_RS07740 (lpp)	100.00	98.73	2.05e-51	Murein lipoprotein	ACY88149
P0AA28	thioredoxin 1	99.08	99.09	3.63e-77	Redox activity	BAA00903
A0A0F6B0W8	STM14_RS07725 (ynhA/sufE)	80.44	99.28	2.89e-83	Cysteine desulfuration protein	ACY88146
A0A0F6B5P3	STM14_RS15200 (srlE)	90.71	99.38	0.0	PTS sorbitol transporter subunit IIB	ACY89837
W9BNM7	FepD (VK055_1928)	85.08	99.40	2.50e-163	Ferric enterobactin transport system permease	AIK80534
W9B580	entE (VK055_1924)	81.27	99.44	0.0	(2,3-dihydroxybenzoyl)adenylate synthase	AIK80530
A0A0F6B5P2	STM14_RS15195 (srlA)	94.65	99.47	5.49e-132	PTS sorbitol transporter subunit IIC	ACY89836
E0SIM9	flhC (Dda3937_02784)	81.25	99.48	3.53e-117	Flagellar transcriptional activator	ADM99088
D2TUX9	dsbA (ROD_38991)	88.89	99.52	6.60e-142	Thiol:disulfide interchange protein	CBG90603
Q56056	RNase III	97.34	99.56	7.94e-166	endoribonucleases	AAA92440
A0A0F6B0W5	STM14_RS07710 (sufC)	93.14	99.60	1.94e-173	Fe-S cluster assembly ATPase	ACY88143
E0SMW9	clpA (Dda3937_02363)	90.75	99.60	0.0	ATP-dependent Clp protease ATP-binding subunit	ADM98239
A0A0F6B5P5	STM14_RS15210 (srlD)	92.66	99.62	2.44e-178	Sorbitol-6-phosphate dehydrogenase	ACY89839
W9B5Y9	FepC (VK055_1930)	86.36	99.62	3.92e-170	Ferric vibriobactin ABC transporter, ATP-binding protein	AIK80536
Q8X6J9	ovrB (Z0346)	88.44	99.66	0.0	LysR-type transcriptional regulator	AE005205_3
W9B576	FepG (VK055_1929)	81.21	99.70	5.36e-177	Ferric enterobactin transport system permease	AIK80535
A0A0F6B0W7	STM14_RS07720 (sufS)	81.53	99.75	0.0	Cysteine desulfurase	ACY88145
A0A0F6B0X2	STM14_RS07745 (pykF)	97.25	100.21	0.0	Pyruvate kinase I	ACY88150
D2TI49	degP (ROD_01651)	91.79	100.21	0.0	Periplasmic serine endoprotease DegP-like	CBG86945
W9B570	FepA (VK055_1934)	83.67	100.54	0.0	TonB-dependent siderophore receptor family protein	AIK80540