ORF_ID e_value Gene_name EC_number CAZy COGs Description
ICIBICIF_00003 4.1e-21 L Transposase
ICIBICIF_00005 4.8e-48 tnp L MULE transposase domain
ICIBICIF_00010 1.2e-134 lysS 6.1.1.6 J Belongs to the class-II aminoacyl-tRNA synthetase family
ICIBICIF_00011 3.4e-171 L Integrase core domain
ICIBICIF_00012 2.7e-73 L transposase, IS605 OrfB family
ICIBICIF_00013 4.8e-190 L Helix-turn-helix domain
ICIBICIF_00014 5.5e-56 L Helix-turn-helix domain
ICIBICIF_00015 3.8e-226 L transposase, IS605 OrfB family
ICIBICIF_00016 8.3e-51 L Helix-turn-helix domain
ICIBICIF_00017 6.2e-85 L hmm pf00665
ICIBICIF_00018 7.1e-239 L transposase, IS605 OrfB family
ICIBICIF_00019 1.1e-80 tlpA2 L Transposase IS200 like
ICIBICIF_00020 4.9e-159 xth 3.1.11.2 L exodeoxyribonuclease III
ICIBICIF_00021 1.4e-53
ICIBICIF_00022 4.5e-16 M domain protein
ICIBICIF_00023 2.2e-235 kgtP EGP Sugar (and other) transporter
ICIBICIF_00024 5.4e-141 fhuC 3.6.3.34 HP ABC transporter, ATP-binding protein
ICIBICIF_00025 7.5e-153 isdF U Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ICIBICIF_00026 2.8e-149 isdE P Periplasmic binding protein
ICIBICIF_00027 1e-94 M Iron Transport-associated domain
ICIBICIF_00028 5e-265 isdH M Iron Transport-associated domain
ICIBICIF_00029 1.2e-43
ICIBICIF_00030 1.3e-73 ydzE EG EamA-like transporter family
ICIBICIF_00031 4.5e-92 P Cadmium resistance transporter
ICIBICIF_00032 1.3e-185 E Arginine ornithine antiporter
ICIBICIF_00033 2.7e-221 yxjG 2.1.1.14 E methionine synthase, vitamin-B12 independent
ICIBICIF_00034 7.6e-216 arcT 2.6.1.1 E Aminotransferase
ICIBICIF_00035 6.9e-239 arcA 3.5.3.6 E Arginine
ICIBICIF_00036 1.4e-167 arcC 2.7.2.2 E Belongs to the carbamate kinase family
ICIBICIF_00037 6e-188 argF 2.1.3.3 E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ICIBICIF_00038 7.9e-149 KT YcbB domain
ICIBICIF_00039 1e-192 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
ICIBICIF_00040 6.7e-173 ppx 3.6.1.11, 3.6.1.40 FP exopolyphosphatase
ICIBICIF_00041 0.0 ppk 2.7.4.1 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ICIBICIF_00042 1.3e-163 D nuclear chromosome segregation
ICIBICIF_00043 1.9e-254 dtpT U amino acid peptide transporter
ICIBICIF_00044 1.3e-164 yjjH S Calcineurin-like phosphoesterase
ICIBICIF_00047 3.3e-115
ICIBICIF_00048 4.3e-132 racD 5.1.1.13 M Belongs to the aspartate glutamate racemases family
ICIBICIF_00049 1.4e-127 gntR1 K UbiC transcription regulator-associated domain protein
ICIBICIF_00050 1.1e-283 pncB 6.3.4.21 F Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ICIBICIF_00051 8.8e-153 nadE 6.3.1.5 F Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
ICIBICIF_00052 0.0 yhgF K Tex-like protein N-terminal domain protein
ICIBICIF_00053 1e-86 ydcK S Belongs to the SprT family
ICIBICIF_00055 0.0 lacL 3.2.1.23 G Belongs to the glycosyl hydrolase 2 family
ICIBICIF_00056 1.8e-189 lacM 3.2.1.23, 3.2.1.35, 3.2.1.51, 3.2.1.97 GH101,GH29 G beta-galactosidase
ICIBICIF_00057 2.3e-168 mleP2 S Sodium Bile acid symporter family
ICIBICIF_00058 1.4e-127 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ICIBICIF_00059 1.3e-167 I alpha/beta hydrolase fold
ICIBICIF_00060 4e-264 pepC 3.4.22.40 E Peptidase C1-like family
ICIBICIF_00061 3.4e-93 maa 2.3.1.18, 2.3.1.79 S Transferase hexapeptide repeat
ICIBICIF_00062 6.7e-122 rpiA 2.7.1.12, 5.3.1.6 G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ICIBICIF_00063 4.2e-55 HA62_12640 S GCN5-related N-acetyl-transferase
ICIBICIF_00064 1.4e-98 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F dUTP diphosphatase
ICIBICIF_00065 5.6e-253 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ICIBICIF_00066 2.7e-205 yacL S domain protein
ICIBICIF_00067 9.6e-291 gltX 6.1.1.17, 6.1.1.24 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ICIBICIF_00068 7.8e-100 ywlG S Belongs to the UPF0340 family
ICIBICIF_00069 1.7e-273 cysS 6.1.1.16, 6.3.1.13 J Belongs to the class-I aminoacyl-tRNA synthetase family
ICIBICIF_00070 5.5e-71 mrnC J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
ICIBICIF_00071 2.6e-135 rlmB 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ICIBICIF_00072 1.1e-104 sigH K Belongs to the sigma-70 factor family
ICIBICIF_00073 3.2e-21 rpmG J Belongs to the bacterial ribosomal protein bL33 family
ICIBICIF_00074 2.4e-23 secE U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
ICIBICIF_00075 5.9e-97 nusG K Participates in transcription elongation, termination and antitermination
ICIBICIF_00076 2.2e-51 rplK J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ICIBICIF_00077 5.7e-121 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
ICIBICIF_00078 4.6e-244 steT E amino acid
ICIBICIF_00079 8.4e-82 rplJ J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ICIBICIF_00080 4.6e-53 rplL J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
ICIBICIF_00081 1.5e-272 cydA 1.10.3.14 C ubiquinol oxidase
ICIBICIF_00082 4.1e-176 cydB 1.10.3.14 C Cytochrome d ubiquinol oxidase subunit II
ICIBICIF_00083 0.0 cydD CO ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydD
ICIBICIF_00084 0.0 cydD CO ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ICIBICIF_00085 0.0 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
ICIBICIF_00086 7.8e-247 brnQ U Component of the transport system for branched-chain amino acids
ICIBICIF_00087 1.9e-194 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ICIBICIF_00088 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ICIBICIF_00089 2e-35 nrdH O Glutaredoxin
ICIBICIF_00090 6.3e-80 tadA 3.5.4.33 F Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
ICIBICIF_00092 0.0 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ICIBICIF_00093 4.9e-40 yaaK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ICIBICIF_00094 3e-110 recR L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ICIBICIF_00095 2.4e-21 S Protein of unknown function (DUF2508)
ICIBICIF_00096 6e-117 tmk 2.7.4.9 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ICIBICIF_00097 1.2e-52 yaaQ S Cyclic-di-AMP receptor
ICIBICIF_00098 4.9e-193 holB 2.7.7.7 L DNA polymerase III
ICIBICIF_00099 1.5e-55 yabA L Involved in initiation control of chromosome replication
ICIBICIF_00100 1.2e-157 rsmI 2.1.1.198 H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ICIBICIF_00101 3.3e-146 fat 3.1.2.21 I Acyl-ACP thioesterase
ICIBICIF_00102 1.1e-281 ppx3 3.6.1.11, 3.6.1.40 FP exopolyphosphatase
ICIBICIF_00104 1.2e-15 C aldo keto reductase
ICIBICIF_00107 4.9e-29 C Aldo keto reductase
ICIBICIF_00108 6.2e-24 C reductase
ICIBICIF_00109 1.2e-79 S Belongs to the short-chain dehydrogenases reductases (SDR) family
ICIBICIF_00110 3.2e-83 S Alpha/beta hydrolase family
ICIBICIF_00111 2.3e-119 pnb C nitroreductase
ICIBICIF_00112 2.3e-83 lacR K Transcriptional regulator
ICIBICIF_00113 1.3e-25 lacS G Transporter
ICIBICIF_00114 9.8e-77
ICIBICIF_00115 1.2e-263 npr 1.11.1.1 C NADH oxidase
ICIBICIF_00116 2.5e-128 L PFAM transposase, IS4 family protein
ICIBICIF_00117 1.9e-21 2.3.1.15 D Antitoxin component of a toxin-antitoxin (TA) module
ICIBICIF_00118 4.6e-23 D mRNA cleavage
ICIBICIF_00119 1.8e-185 S Phosphotransferase system, EIIC
ICIBICIF_00120 2e-194 nhaC C Na H antiporter NhaC
ICIBICIF_00122 3.1e-75 ddaH 3.5.3.18 E Amidinotransferase
ICIBICIF_00123 1.4e-89 S Aminoacyl-tRNA editing domain
ICIBICIF_00124 0.0 mco Q Multicopper oxidase
ICIBICIF_00125 2.8e-51 K 2 iron, 2 sulfur cluster binding
ICIBICIF_00126 2.5e-90 1.5.1.40 S NADP oxidoreductase coenzyme F420-dependent
ICIBICIF_00127 2.8e-120 Q Methyltransferase domain
ICIBICIF_00129 1.2e-103 S CAAX protease self-immunity
ICIBICIF_00130 1.2e-27 ogt 2.1.1.63, 3.2.2.20 L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ICIBICIF_00131 1.1e-25 ogt 2.1.1.63, 3.2.2.20 L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ICIBICIF_00132 2.3e-39 fsr EGP Major Facilitator Superfamily
ICIBICIF_00133 6.6e-64 fsr EGP Major Facilitator Superfamily
ICIBICIF_00134 1.4e-101 K helix_turn_helix multiple antibiotic resistance protein
ICIBICIF_00135 1.3e-184 brpA K Cell envelope-like function transcriptional attenuator common domain protein
ICIBICIF_00136 1.6e-105
ICIBICIF_00137 8.4e-84 dps P Belongs to the Dps family
ICIBICIF_00138 2.4e-303 ybiT S ABC transporter, ATP-binding protein
ICIBICIF_00139 2.3e-33 yneR S Belongs to the HesB IscA family
ICIBICIF_00140 4.7e-140 S NADPH-dependent FMN reductase
ICIBICIF_00141 4.5e-288 gshF 6.3.2.2 H Belongs to the glutamate--cysteine ligase type 1 family
ICIBICIF_00142 1.9e-161 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
ICIBICIF_00143 1.4e-104 yvdD 3.2.2.10 S Belongs to the LOG family
ICIBICIF_00144 4.9e-63 S Domain of unknown function (DUF4828)
ICIBICIF_00145 1.3e-190 mocA S Oxidoreductase
ICIBICIF_00146 6.8e-232 yfmL 3.6.4.13 L DEAD DEAH box helicase
ICIBICIF_00148 1.1e-74 gtcA S Teichoic acid glycosylation protein
ICIBICIF_00149 4.2e-77 fld C Flavodoxin
ICIBICIF_00150 1.7e-167 map 3.4.11.18 E Methionine Aminopeptidase
ICIBICIF_00151 0.0 XK27_08315 M Sulfatase
ICIBICIF_00152 1e-138 yihY S Belongs to the UPF0761 family
ICIBICIF_00153 3.8e-31 S Protein of unknown function (DUF2922)
ICIBICIF_00154 1.3e-07
ICIBICIF_00155 4.2e-147 recX 2.4.1.337 GT4 S Regulatory protein RecX
ICIBICIF_00156 1.1e-118 rfbP M Bacterial sugar transferase
ICIBICIF_00157 1.1e-146 cps1D M Domain of unknown function (DUF4422)
ICIBICIF_00158 5.5e-95 cps3F
ICIBICIF_00159 4.5e-45 M biosynthesis protein
ICIBICIF_00160 2.5e-219 glf 5.4.99.9 M UDP-galactopyranose mutase
ICIBICIF_00161 1.2e-202 rfbX S Membrane protein involved in the export of O-antigen and teichoic acid
ICIBICIF_00162 4e-73 S enterobacterial common antigen metabolic process
ICIBICIF_00163 9.5e-59 acmD M repeat protein
ICIBICIF_00165 2.9e-60 3.2.1.96, 3.5.1.28 GH73 M repeat protein
ICIBICIF_00166 3e-64 M repeat protein
ICIBICIF_00167 8.1e-09
ICIBICIF_00168 2.9e-160 yfdH 2.4.2.53 GT2 M Glycosyltransferase, group 2 family protein
ICIBICIF_00169 4.6e-141 yueF S AI-2E family transporter
ICIBICIF_00170 7.7e-164 ykoT GT2 M Glycosyl transferase family 2
ICIBICIF_00171 7.7e-307 prfC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ICIBICIF_00172 1.3e-95 M transferase activity, transferring glycosyl groups
ICIBICIF_00173 9.2e-103 glfT1 1.1.1.133 S Glycosyltransferase like family 2
ICIBICIF_00174 2.5e-88 S Bacterial membrane protein, YfhO
ICIBICIF_00175 8.1e-171 rfbB 4.2.1.46 M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
ICIBICIF_00176 7.8e-64 gntR1 K Transcriptional regulator, GntR family
ICIBICIF_00177 6.8e-156 V ABC transporter, ATP-binding protein
ICIBICIF_00178 5.5e-15
ICIBICIF_00180 3.5e-246 yxbA 6.3.1.12 S ATP-grasp enzyme
ICIBICIF_00181 2.5e-161 EG EamA-like transporter family
ICIBICIF_00182 8.4e-137 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ICIBICIF_00183 3.6e-142 manA 1.14.13.81, 5.3.1.8, 5.4.2.8 G MucBP domain
ICIBICIF_00184 1.7e-97 S Pfam:DUF3816
ICIBICIF_00185 7.8e-266 pncB 6.3.4.21 F Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ICIBICIF_00186 6.4e-110 pncA Q Isochorismatase family
ICIBICIF_00187 6.4e-128 3.6.1.13, 3.6.1.55 F NUDIX domain
ICIBICIF_00188 0.0 clpE O Belongs to the ClpA ClpB family
ICIBICIF_00190 1.4e-38 ptsH G phosphocarrier protein HPR
ICIBICIF_00191 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ICIBICIF_00192 3.4e-230 mgs 2.4.1.337 GT4 M Glycosyltransferase, group 1 family protein
ICIBICIF_00193 1.5e-199 cpoA GT4 M Glycosyltransferase, group 1 family protein
ICIBICIF_00194 5.5e-181 mprF I Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ICIBICIF_00195 9.7e-39 ykuJ S Protein of unknown function (DUF1797)
ICIBICIF_00196 7.6e-180 1.1.1.26 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ICIBICIF_00197 7.2e-37 pucG 2.6.1.112, 2.6.1.44, 2.6.1.45, 2.6.1.51 E Aminotransferase class-V
ICIBICIF_00198 2.9e-100 pucG 2.6.1.112, 2.6.1.44, 2.6.1.45, 2.6.1.51 E Aminotransferase class-V
ICIBICIF_00199 4.3e-41 sucD 6.2.1.5 C Protein of unknown function (DUF1116)
ICIBICIF_00202 7.7e-121 arcC 2.7.2.2 E Amino acid kinase family
ICIBICIF_00203 1.2e-67 rihA 3.2.2.1 F Inosine-uridine preferring nucleoside hydrolase
ICIBICIF_00204 2.8e-34 rihA 3.2.2.1 F Inosine-uridine preferring nucleoside hydrolase
ICIBICIF_00205 1.1e-123 C nitroreductase
ICIBICIF_00206 4.6e-137 E GDSL-like Lipase/Acylhydrolase family
ICIBICIF_00207 2.3e-53 S Mazg nucleotide pyrophosphohydrolase
ICIBICIF_00208 2.1e-196 1.1.1.1, 1.1.1.14 E alcohol dehydrogenase
ICIBICIF_00209 0.0 pepN 3.4.11.2 E aminopeptidase
ICIBICIF_00210 1.7e-60 K Transcriptional regulator
ICIBICIF_00211 1e-24 phaG GT1 I carboxylic ester hydrolase activity
ICIBICIF_00212 2.1e-140 nfrA 1.5.1.38, 1.5.1.39 C nitroreductase
ICIBICIF_00214 4.3e-155 metQ_4 P Belongs to the nlpA lipoprotein family
ICIBICIF_00215 1.2e-203 napA P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
ICIBICIF_00216 0.0 helD 3.6.4.12 L DNA helicase
ICIBICIF_00217 6.6e-173 ppx 3.6.1.11, 3.6.1.40 FP exopolyphosphatase
ICIBICIF_00218 4e-221 mvaA 1.1.1.34, 1.1.1.88, 2.3.1.9 C Belongs to the HMG-CoA reductase family
ICIBICIF_00219 2.2e-187
ICIBICIF_00220 4.4e-129 cobB K SIR2 family
ICIBICIF_00221 5.3e-212 norA EGP Major facilitator Superfamily
ICIBICIF_00222 6.2e-162 yunF F Protein of unknown function DUF72
ICIBICIF_00223 0.0 metG 6.1.1.10 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ICIBICIF_00224 1.8e-147 tatD L hydrolase, TatD family
ICIBICIF_00225 5.6e-98 rnmV 3.1.26.8 J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ICIBICIF_00226 2.5e-161 ksgA 2.1.1.182 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
ICIBICIF_00227 1.3e-159 ispE 2.1.1.182, 2.7.1.148 F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ICIBICIF_00228 1.2e-166 znuA P Belongs to the bacterial solute-binding protein 9 family
ICIBICIF_00229 5.4e-95 fhuC P ABC transporter
ICIBICIF_00230 3.2e-128 znuB U ABC 3 transport family
ICIBICIF_00231 7.5e-152 purR 2.4.2.22, 2.4.2.7 F pur operon repressor
ICIBICIF_00232 1.6e-204 glmU 2.3.1.157, 2.7.7.23 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ICIBICIF_00233 3.6e-177 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ICIBICIF_00234 3e-32
ICIBICIF_00235 4.8e-143 yxeH S hydrolase
ICIBICIF_00236 5.7e-266 ywfO S HD domain protein
ICIBICIF_00237 3.2e-74 ywiB S Domain of unknown function (DUF1934)
ICIBICIF_00238 1.6e-47 rpoE K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
ICIBICIF_00239 1.1e-310 pyrG 6.3.4.2 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
ICIBICIF_00240 2.3e-237 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ICIBICIF_00241 6e-41 rpmE2 J Ribosomal protein L31
ICIBICIF_00242 3.3e-29 mdtG EGP Major facilitator Superfamily
ICIBICIF_00243 1.6e-16 mdtG EGP Major facilitator Superfamily
ICIBICIF_00244 1e-122 srtA 3.4.22.70 M sortase family
ICIBICIF_00245 6.2e-47 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ICIBICIF_00246 8.7e-88 lemA S LemA family
ICIBICIF_00247 2.4e-156 htpX O Belongs to the peptidase M48B family
ICIBICIF_00248 3.3e-138 murF 6.3.2.10, 6.3.2.13 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
ICIBICIF_00249 5.4e-254 cshA 3.6.4.13 F DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
ICIBICIF_00250 2.9e-60 acpS 2.7.6.3, 2.7.8.7, 5.1.1.1 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
ICIBICIF_00251 9.6e-211 alr 5.1.1.1 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ICIBICIF_00252 7.3e-56 L Toxic component of a toxin-antitoxin (TA) module
ICIBICIF_00253 8.1e-114 S (CBS) domain
ICIBICIF_00254 9.6e-103 pth 3.1.1.29 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
ICIBICIF_00255 0.0 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ICIBICIF_00256 4.8e-39 yabO J S4 domain protein
ICIBICIF_00257 5.6e-56 divIC D Septum formation initiator
ICIBICIF_00258 3e-87 yabR J RNA binding
ICIBICIF_00259 3.8e-254 tilS 2.4.2.8, 6.3.4.19 J Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
ICIBICIF_00260 4.1e-98 hpt 2.4.2.8 F Belongs to the purine pyrimidine phosphoribosyltransferase family
ICIBICIF_00261 0.0 ftsH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ICIBICIF_00262 7.6e-163 hslO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ICIBICIF_00263 1.9e-189 dus J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ICIBICIF_00273 1.4e-07 K Bacterial regulatory proteins, tetR family
ICIBICIF_00275 2.2e-11 qacC P COG2076 Membrane transporters of cations and cationic drugs
ICIBICIF_00276 2.4e-142 ET Bacterial periplasmic substrate-binding proteins
ICIBICIF_00277 2e-110 XK27_05795 P ABC transporter permease
ICIBICIF_00278 0.0 nrdD 1.1.98.6 F Ribonucleoside-triphosphate reductase
ICIBICIF_00279 5.3e-112 nrdG 1.97.1.4 O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ICIBICIF_00280 5.4e-161 sufD O Uncharacterized protein family (UPF0051)
ICIBICIF_00281 4.6e-236 F Permease
ICIBICIF_00282 4.6e-199 adh 1.1.1.1, 1.1.1.14 C Zinc-binding dehydrogenase
ICIBICIF_00283 3e-63 lytE M LysM domain protein
ICIBICIF_00284 1.6e-85 ykhA 3.1.2.20 I Thioesterase superfamily
ICIBICIF_00285 1.1e-77 hsp O Belongs to the small heat shock protein (HSP20) family
ICIBICIF_00286 4e-114 K Transcriptional regulator, TetR family
ICIBICIF_00288 4e-22
ICIBICIF_00289 1.6e-247 cycA E Amino acid permease
ICIBICIF_00290 7.4e-85 perR P Belongs to the Fur family
ICIBICIF_00291 4.4e-253 EGP Major facilitator Superfamily
ICIBICIF_00292 3.4e-97 tag 3.2.2.20 L glycosylase
ICIBICIF_00293 1.3e-51
ICIBICIF_00294 3e-210 metK 2.5.1.6 H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ICIBICIF_00295 3.7e-140 proB 2.7.2.11 F Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ICIBICIF_00296 7.6e-225 proA 1.2.1.41 E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ICIBICIF_00297 1.6e-126 3.1.3.2, 3.1.3.27, 3.1.3.4, 3.1.3.81, 3.6.1.27 I Acid phosphatase homologues
ICIBICIF_00298 0.0 leuS 6.1.1.4 J Belongs to the class-I aminoacyl-tRNA synthetase family
ICIBICIF_00299 2.6e-42
ICIBICIF_00300 2.8e-299 ytgP S Polysaccharide biosynthesis protein
ICIBICIF_00301 1.5e-62 3.2.1.23 S Domain of unknown function DUF302
ICIBICIF_00302 1.3e-157 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ICIBICIF_00303 8.4e-273 pepV 3.5.1.18 E dipeptidase PepV
ICIBICIF_00304 5.1e-87 uspA T Belongs to the universal stress protein A family
ICIBICIF_00305 2.4e-256 S Putative peptidoglycan binding domain
ICIBICIF_00306 9.4e-166 3.2.1.17 NU Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
ICIBICIF_00307 8.6e-116 dck 2.7.1.74 F deoxynucleoside kinase
ICIBICIF_00308 3.6e-111
ICIBICIF_00309 1.7e-182 rbsR K Periplasmic binding proteins and sugar binding domain of LacI family
ICIBICIF_00310 6.9e-119 S CAAX protease self-immunity
ICIBICIF_00311 8.4e-63 folB 1.13.11.81, 2.5.1.15, 2.7.6.3, 4.1.2.25, 5.1.99.8 H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ICIBICIF_00312 8.4e-93 folK 1.13.11.81, 2.5.1.15, 2.7.6.3, 3.5.4.16, 4.1.2.25, 5.1.99.8 H 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)
ICIBICIF_00313 8.9e-104 folE 2.7.6.3, 3.5.4.16 F GTP cyclohydrolase 1
ICIBICIF_00314 9.8e-244 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
ICIBICIF_00315 2.6e-106 xtp 2.5.1.15, 3.6.1.66 F Ham1 family
ICIBICIF_00316 2.4e-201 folP 2.5.1.15 H dihydropteroate synthase
ICIBICIF_00318 1.7e-36
ICIBICIF_00320 0.0 argS 6.1.1.19 J Arginyl-tRNA synthetase
ICIBICIF_00321 0.0 pbp2A 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
ICIBICIF_00322 9.8e-56 yheA S Belongs to the UPF0342 family
ICIBICIF_00323 1.3e-179 yhaM S Metal dependent phosphohydrolases with conserved 'HD' motif.
ICIBICIF_00324 6.7e-149 prsA 5.2.1.8 M Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins
ICIBICIF_00326 1.4e-77 hit FG histidine triad
ICIBICIF_00327 2.6e-132 ecsA V ABC transporter, ATP-binding protein
ICIBICIF_00328 1e-210 ecsB U ABC transporter
ICIBICIF_00329 1.8e-124 trmB 2.1.1.297, 2.1.1.33 J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
ICIBICIF_00330 3.3e-58 ytzB S Small secreted protein
ICIBICIF_00331 6.5e-56 ytpP 2.7.1.180, 5.3.4.1 CO Thioredoxin
ICIBICIF_00332 2e-117 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
ICIBICIF_00333 1.4e-250 mpl 6.3.2.4, 6.3.2.45, 6.3.2.8 M Belongs to the MurCDEF family
ICIBICIF_00334 1.8e-114 ybhL S Belongs to the BI1 family
ICIBICIF_00335 6.5e-139 aroD S Serine hydrolase (FSH1)
ICIBICIF_00336 0.0 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ICIBICIF_00337 2.1e-162 fpg 3.2.2.23, 4.2.99.18 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
ICIBICIF_00338 3.5e-106 coaE 2.7.1.24 F Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ICIBICIF_00339 3.2e-80 nrdR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ICIBICIF_00340 1e-251 dnaB L replication initiation and membrane attachment
ICIBICIF_00341 7.4e-172 dnaI L Primosomal protein DnaI
ICIBICIF_00342 1.7e-85 infC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ICIBICIF_00343 1.5e-26 rpmI J Belongs to the bacterial ribosomal protein bL35 family
ICIBICIF_00344 6.6e-57 rplT J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ICIBICIF_00345 1.9e-19 yoaK S Protein of unknown function (DUF1275)
ICIBICIF_00346 1.6e-25 yoaK S Protein of unknown function (DUF1275)
ICIBICIF_00347 2.2e-96 yqeG S HAD phosphatase, family IIIA
ICIBICIF_00348 2.6e-216 yqeH S Ribosome biogenesis GTPase YqeH
ICIBICIF_00349 2.6e-49 yhbY J RNA-binding protein
ICIBICIF_00350 4.1e-94 nadD 2.7.7.18, 3.6.1.55 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ICIBICIF_00351 7.3e-112 nadD 2.7.6.3, 2.7.7.18 H Hydrolase, HD family
ICIBICIF_00352 1.6e-58 rsfS J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
ICIBICIF_00353 8.3e-142 yqeM Q Methyltransferase
ICIBICIF_00354 5.5e-214 ylbM S Belongs to the UPF0348 family
ICIBICIF_00355 1.7e-96 yceD S Uncharacterized ACR, COG1399
ICIBICIF_00356 7.2e-28 rpmF J Belongs to the bacterial ribosomal protein bL32 family
ICIBICIF_00357 5.6e-121 K response regulator
ICIBICIF_00358 9e-281 arlS 2.7.13.3 T Histidine kinase
ICIBICIF_00359 1.2e-233 V MatE
ICIBICIF_00360 3e-69 def_1 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins
ICIBICIF_00361 7.2e-132 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
ICIBICIF_00362 4.1e-46 acyP 3.6.1.7 C Belongs to the acylphosphatase family
ICIBICIF_00363 1.2e-141 spoU 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ICIBICIF_00364 1.3e-90 XK27_09705 6.1.1.14 S Metal dependent phosphohydrolases with conserved 'HD' motif.
ICIBICIF_00365 7.8e-60 yodB K Transcriptional regulator, HxlR family
ICIBICIF_00366 5.1e-198 pheS 6.1.1.20 J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ICIBICIF_00367 0.0 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
ICIBICIF_00368 3e-116 udk 2.7.1.48 F Cytidine monophosphokinase
ICIBICIF_00369 2.2e-79 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
ICIBICIF_00370 0.0 S membrane
ICIBICIF_00371 0.0 pbp2b 3.4.16.4 M Penicillin-binding Protein
ICIBICIF_00372 3.2e-21 rpmG J Belongs to the bacterial ribosomal protein bL33 family
ICIBICIF_00373 9.2e-98 ygfA 6.3.3.2 H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ICIBICIF_00374 4e-116 gluP 3.4.21.105 S Peptidase, S54 family
ICIBICIF_00375 9.6e-36 yqgQ S Bacterial protein of unknown function (DUF910)
ICIBICIF_00376 2.6e-180 glk 2.7.1.2 G Glucokinase
ICIBICIF_00377 1.5e-71 yqhL P Rhodanese-like protein
ICIBICIF_00378 4.8e-24 WQ51_02665 S Protein of unknown function (DUF3042)
ICIBICIF_00379 3.2e-172 miaA 2.5.1.75 F Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ICIBICIF_00380 3.8e-262 glnA 6.3.1.2 E glutamine synthetase
ICIBICIF_00381 5.4e-148
ICIBICIF_00382 5.4e-178
ICIBICIF_00383 6.6e-93 dut S Protein conserved in bacteria
ICIBICIF_00385 2.8e-114 K Transcriptional regulator
ICIBICIF_00386 1.8e-50 rplU J This protein binds to 23S rRNA in the presence of protein L20
ICIBICIF_00387 9e-53 ysxB J Cysteine protease Prp
ICIBICIF_00388 7.1e-46 rpmA J Belongs to the bacterial ribosomal protein bL27 family
ICIBICIF_00389 8.1e-207 pepP 3.4.11.9, 3.4.13.9 E Creatinase/Prolidase N-terminal domain
ICIBICIF_00390 4.1e-72 yqhY S Asp23 family, cell envelope-related function
ICIBICIF_00391 4e-69 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ICIBICIF_00392 2.6e-160 folD 1.5.1.5, 3.5.4.9 F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ICIBICIF_00393 2.3e-257 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
ICIBICIF_00394 1e-18 xseB 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
ICIBICIF_00395 9.6e-158 ispA 2.5.1.1, 2.5.1.10, 2.5.1.29, 2.5.1.90 H Belongs to the FPP GGPP synthase family
ICIBICIF_00396 6.4e-148 rrmJ 2.1.1.226, 2.1.1.227 J Ribosomal RNA large subunit methyltransferase J
ICIBICIF_00397 6.2e-76 argR K Regulates arginine biosynthesis genes
ICIBICIF_00398 8.3e-307 recN L May be involved in recombinational repair of damaged DNA
ICIBICIF_00399 3.3e-15
ICIBICIF_00400 3.9e-113 gmk 2.7.4.8 F Essential for recycling GMP and indirectly, cGMP
ICIBICIF_00401 1.2e-45 rpoZ 2.7.7.6 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
ICIBICIF_00402 5e-221 coaBC 4.1.1.36, 6.3.2.5 H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ICIBICIF_00403 0.0 priA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ICIBICIF_00404 2.7e-174 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ICIBICIF_00405 2.2e-246 sun 2.1.1.176 J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ICIBICIF_00406 2.2e-131 stp 3.1.3.16 T phosphatase
ICIBICIF_00407 0.0 KLT serine threonine protein kinase
ICIBICIF_00408 2.2e-165 rsgA 3.1.3.100 S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
ICIBICIF_00409 1.1e-118 rpe 5.1.3.1 G Belongs to the ribulose-phosphate 3-epimerase family
ICIBICIF_00410 1.2e-123 thiN 2.7.6.2 H thiamine pyrophosphokinase
ICIBICIF_00411 2.7e-25 rpmB J Belongs to the bacterial ribosomal protein bL28 family
ICIBICIF_00412 3.6e-58 asp S Asp23 family, cell envelope-related function
ICIBICIF_00413 1.7e-304 yloV S DAK2 domain fusion protein YloV
ICIBICIF_00414 0.0 recG 3.6.4.12 L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ICIBICIF_00415 8.1e-164 plsX 2.3.1.15 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
ICIBICIF_00416 4.5e-36 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
ICIBICIF_00417 4e-130 rnc 3.1.26.3 J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
ICIBICIF_00418 0.0 smc D Required for chromosome condensation and partitioning
ICIBICIF_00419 1.9e-180 ftsY U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
ICIBICIF_00420 1.1e-56 ylxM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
ICIBICIF_00421 2.6e-245 ffh 3.6.5.4 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ICIBICIF_00423 2.7e-95
ICIBICIF_00424 7.5e-129 K Transcriptional regulatory protein, C-terminal domain protein
ICIBICIF_00425 1.1e-158 pstS P Phosphate
ICIBICIF_00426 1.9e-153 pstC P probably responsible for the translocation of the substrate across the membrane
ICIBICIF_00427 5.5e-153 pstA P Phosphate transport system permease protein PstA
ICIBICIF_00428 6.8e-136 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
ICIBICIF_00429 1.1e-122 phoU P Plays a role in the regulation of phosphate uptake
ICIBICIF_00430 2.9e-44 rpsP J Belongs to the bacterial ribosomal protein bS16 family
ICIBICIF_00431 3.5e-39 ylqC S Belongs to the UPF0109 family
ICIBICIF_00432 2.1e-88 rimM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ICIBICIF_00433 2.9e-142 trmD 2.1.1.228, 4.6.1.12 J Belongs to the RNA methyltransferase TrmD family
ICIBICIF_00434 1.7e-260 yfnA E Amino Acid
ICIBICIF_00435 2.1e-58 rplS J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
ICIBICIF_00436 0.0 gtfC 2.4.1.5 GH13 G Glycosyl hydrolase family 70
ICIBICIF_00437 1.7e-56 ycsI S Protein of unknown function (DUF1445)
ICIBICIF_00438 2e-180 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
ICIBICIF_00439 2.3e-245 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
ICIBICIF_00440 8.7e-209 carA 6.3.5.5 F Carbamoyl-phosphate synthetase glutamine chain
ICIBICIF_00441 0.0 carB 6.3.5.5 F Carbamoyl-phosphate synthase
ICIBICIF_00442 9.1e-167 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
ICIBICIF_00443 4.5e-154 yitU 3.1.3.104 S hydrolase
ICIBICIF_00444 9.7e-274 rsmF 2.1.1.176, 2.1.1.178 J NOL1 NOP2 sun family protein
ICIBICIF_00445 1.7e-44 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
ICIBICIF_00446 3.6e-38 pstB 3.6.3.27 L Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
ICIBICIF_00447 1.5e-205 fni 1.1.1.88, 5.3.3.2 C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
ICIBICIF_00448 1.5e-211 mvaK2 2.7.1.36, 2.7.1.43, 2.7.4.2 I phosphomevalonate kinase
ICIBICIF_00449 8.2e-182 mvaD 4.1.1.33 I diphosphomevalonate decarboxylase
ICIBICIF_00450 2.2e-168 mvk 1.1.1.88, 2.3.3.10, 2.7.1.36 I mevalonate kinase
ICIBICIF_00451 0.0 dinG 2.7.7.7, 3.6.4.12 L helicase involved in DNA repair and perhaps also replication
ICIBICIF_00452 1.4e-87 ypmB S Protein conserved in bacteria
ICIBICIF_00453 2.1e-257 asnS 6.1.1.22 J Asparaginyl-tRNA synthetase
ICIBICIF_00454 4.7e-134 dnaD L DnaD domain protein
ICIBICIF_00455 1.3e-121 ypuA S Protein of unknown function (DUF1002)
ICIBICIF_00456 3.7e-193 C Aldo keto reductase family protein
ICIBICIF_00457 4.8e-160 EG EamA-like transporter family
ICIBICIF_00458 0.0 ponA 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein 1A
ICIBICIF_00459 1.2e-117 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
ICIBICIF_00460 6e-111 ypsA S Belongs to the UPF0398 family
ICIBICIF_00461 4.6e-58 gpsB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
ICIBICIF_00462 0.0 tetP J elongation factor G
ICIBICIF_00463 1.4e-212 S Type IV secretion-system coupling protein DNA-binding domain
ICIBICIF_00464 8.9e-83 F Hydrolase, NUDIX family
ICIBICIF_00465 8.5e-215 rlmL 2.1.1.173, 2.1.1.264 L Belongs to the methyltransferase superfamily
ICIBICIF_00466 5.4e-129 arcD S C4-dicarboxylate anaerobic carrier
ICIBICIF_00467 3.4e-272 nylA 3.5.1.4 J Belongs to the amidase family
ICIBICIF_00468 4.2e-21 M Glycosyltransferase like family 2
ICIBICIF_00469 1.2e-118 yecS E ABC transporter permease
ICIBICIF_00470 4e-156 yckB ET Belongs to the bacterial solute-binding protein 3 family
ICIBICIF_00471 2.8e-108 XK27_02070 S Nitroreductase family
ICIBICIF_00472 3.1e-71 rnhA 3.1.26.4 L Ribonuclease HI
ICIBICIF_00473 1.7e-70 esbA S Family of unknown function (DUF5322)
ICIBICIF_00474 3e-75 lspA 3.4.23.36 MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ICIBICIF_00475 1e-173 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
ICIBICIF_00476 1.4e-206 carA 6.3.5.5 F Belongs to the CarA family
ICIBICIF_00477 0.0 carB 6.3.5.5 F Carbamoyl-phosphate synthase
ICIBICIF_00478 6.4e-119 cah 4.2.1.1 P Eukaryotic-type carbonic anhydrase
ICIBICIF_00479 3.5e-29 akr5f S reductase
ICIBICIF_00480 2.5e-28 akr5f 1.1.1.346 S reductase
ICIBICIF_00481 8.3e-43 S Bacterial transferase hexapeptide (six repeats)
ICIBICIF_00482 1.5e-49 C Flavodoxin
ICIBICIF_00483 5.9e-103 P nitric oxide dioxygenase activity
ICIBICIF_00484 0.0 FbpA K Fibronectin-binding protein
ICIBICIF_00485 3.2e-161 degV S EDD domain protein, DegV family
ICIBICIF_00486 1.3e-97
ICIBICIF_00487 2e-132 S Belongs to the UPF0246 family
ICIBICIF_00488 1.5e-118 ypgQ S Metal dependent phosphohydrolases with conserved 'HD' motif.
ICIBICIF_00489 5.3e-113 ylbE GM NAD(P)H-binding
ICIBICIF_00490 3.5e-99 K Acetyltransferase (GNAT) domain
ICIBICIF_00491 8e-157 thrB 2.7.1.39 F Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
ICIBICIF_00492 1.2e-233 hom 1.1.1.3, 2.7.2.4 E homoserine dehydrogenase
ICIBICIF_00493 1.9e-286 thrC 4.2.3.1 E Threonine synthase
ICIBICIF_00494 7e-105 azlC E azaleucine resistance protein AzlC
ICIBICIF_00495 2.8e-54 azlD E Branched-chain amino acid transport
ICIBICIF_00496 7.3e-55 yphJ 4.1.1.44 S decarboxylase
ICIBICIF_00497 4.8e-183 pdhA 1.2.4.1, 1.2.4.4 C Dehydrogenase E1 component
ICIBICIF_00498 5.8e-180 pdhB 1.2.4.1 C Transketolase, C-terminal domain protein
ICIBICIF_00499 2.9e-203 pdhC 2.3.1.12 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
ICIBICIF_00500 3.1e-259 lpdA 1.8.1.4 C Dehydrogenase
ICIBICIF_00501 2.3e-195 lplA 6.3.1.20 H Lipoate-protein ligase
ICIBICIF_00502 1.5e-216 E GDSL-like Lipase/Acylhydrolase family
ICIBICIF_00503 1.4e-80 K LysR substrate binding domain protein
ICIBICIF_00504 1.2e-11 naiP EGP Major facilitator Superfamily
ICIBICIF_00505 5.3e-251 yhdP S Transporter associated domain
ICIBICIF_00506 6.8e-202 mdtG EGP Major facilitator Superfamily
ICIBICIF_00507 1.1e-91 EGP Major facilitator Superfamily
ICIBICIF_00508 2.1e-56 EGP Major facilitator Superfamily
ICIBICIF_00509 1.6e-168 T Calcineurin-like phosphoesterase superfamily domain
ICIBICIF_00510 5.4e-43 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ICIBICIF_00511 8.8e-240 pts13C G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
ICIBICIF_00512 3.4e-158 S Alpha/beta hydrolase of unknown function (DUF915)
ICIBICIF_00513 4.8e-276 pipD E Dipeptidase
ICIBICIF_00514 0.0 yjbQ P TrkA C-terminal domain protein
ICIBICIF_00515 5.4e-26 dmpI 5.3.2.6 G Belongs to the 4-oxalocrotonate tautomerase family
ICIBICIF_00516 3.9e-284 glpK 2.7.1.30 F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ICIBICIF_00518 1.6e-49
ICIBICIF_00519 0.0 S Bacterial membrane protein YfhO
ICIBICIF_00521 2.7e-237 lmrB EGP Major facilitator Superfamily
ICIBICIF_00522 3e-86 S Alpha beta hydrolase
ICIBICIF_00523 2.6e-42 S Alpha beta hydrolase
ICIBICIF_00524 3.5e-91 1.6.5.2 GM NAD(P)H-binding
ICIBICIF_00525 6.3e-45 1.6.5.2 GM NAD(P)H-binding
ICIBICIF_00526 2.5e-152 S Sucrose-6F-phosphate phosphohydrolase
ICIBICIF_00529 6.9e-249 dtpT U amino acid peptide transporter
ICIBICIF_00531 4.1e-212 ydiN G Major Facilitator Superfamily
ICIBICIF_00532 7.6e-13 pheA 1.3.1.12, 2.3.1.79, 4.2.1.51, 5.4.99.5 E Chorismate mutase type II
ICIBICIF_00533 6.7e-215 aroC 4.2.3.5 E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ICIBICIF_00534 5e-104
ICIBICIF_00535 1e-235 aroA 1.3.1.12, 1.3.1.43, 2.5.1.19 E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
ICIBICIF_00536 6.9e-198 tyrA 1.3.1.12, 1.3.1.43 E prephenate dehydrogenase
ICIBICIF_00537 8.7e-90 aroK 1.1.1.25, 2.7.1.71, 4.2.1.10, 4.2.3.4 F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ICIBICIF_00538 7.8e-216 aspB E DegT/DnrJ/EryC1/StrS aminotransferase family
ICIBICIF_00539 7.4e-183 1.1.1.28 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ICIBICIF_00540 2.5e-178 hepT 2.5.1.30, 2.5.1.90 H Belongs to the FPP GGPP synthase family
ICIBICIF_00541 2.4e-156 menA 2.5.1.74 H 1,4-dihydroxy-2-naphthoate
ICIBICIF_00542 6.7e-23 S Virus attachment protein p12 family
ICIBICIF_00543 0.0 feoB P transporter of a GTP-driven Fe(2 ) uptake system
ICIBICIF_00544 1.4e-33 feoA P FeoA domain
ICIBICIF_00545 8.5e-145 sufC O FeS assembly ATPase SufC
ICIBICIF_00546 4.5e-244 sufD O FeS assembly protein SufD
ICIBICIF_00547 1.8e-234 sufS 2.8.1.7, 4.4.1.16 E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ICIBICIF_00548 4.2e-83 nifU C SUF system FeS assembly protein, NifU family
ICIBICIF_00549 2.1e-271 sufB O assembly protein SufB
ICIBICIF_00550 5.6e-184 fecB P Periplasmic binding protein
ICIBICIF_00551 2.4e-142 EG EamA-like transporter family
ICIBICIF_00552 4.7e-257 XK27_04775 S PAS domain
ICIBICIF_00553 4.7e-19 M1-755 S Domain of unknown function (DUF1858)
ICIBICIF_00554 8e-54 yitW S Iron-sulfur cluster assembly protein
ICIBICIF_00555 1e-229 ndh 1.6.99.3 C NADH dehydrogenase
ICIBICIF_00556 2.2e-142 fecE 3.6.3.34 HP AAA domain, putative AbiEii toxin, Type IV TA system
ICIBICIF_00557 1.5e-170 fecD P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ICIBICIF_00558 5.5e-68 S Flavodoxin
ICIBICIF_00559 2.2e-72 moaE 2.8.1.12 H MoaE protein
ICIBICIF_00560 6.4e-35 moaD 2.8.1.12 H ThiS family
ICIBICIF_00561 7.8e-196 moaA 4.1.99.22 H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ICIBICIF_00562 3.6e-216 narK P Major Facilitator Superfamily
ICIBICIF_00563 1.5e-58 yitW S Iron-sulfur cluster assembly protein
ICIBICIF_00564 2.9e-162 hipB K Helix-turn-helix
ICIBICIF_00565 4.6e-134 menG 2.1.1.163, 2.1.1.201 H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)
ICIBICIF_00567 2e-169 hepT 2.5.1.30, 2.5.1.90 H geranyltranstransferase activity
ICIBICIF_00568 8.8e-184
ICIBICIF_00569 1.8e-38
ICIBICIF_00570 1.2e-115 nreC K PFAM regulatory protein LuxR
ICIBICIF_00571 1.6e-183 comP 2.7.13.3 F Sensor histidine kinase
ICIBICIF_00572 1.4e-77 nreA T GAF domain
ICIBICIF_00573 4.2e-40
ICIBICIF_00574 1.1e-98 mobA 2.7.7.77 H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
ICIBICIF_00575 9.3e-85 moaC 4.6.1.17 H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)
ICIBICIF_00576 1.2e-230 moeA 2.10.1.1 H MoeA N-terminal region (domain I and II)
ICIBICIF_00577 4.3e-86 moaB 2.7.7.75 H May be involved in the biosynthesis of molybdopterin
ICIBICIF_00578 1.4e-189 moeB 2.7.7.73, 2.7.7.80 H ThiF family
ICIBICIF_00579 0.0 narG 1.7.5.1 C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ICIBICIF_00580 0.0 narH 1.7.5.1 C Respiratory nitrate reductase beta C-terminal
ICIBICIF_00581 1.2e-101 narJ C Nitrate reductase delta subunit
ICIBICIF_00582 1.3e-184
ICIBICIF_00583 1.3e-75
ICIBICIF_00584 1.4e-32 yjcE P Sodium proton antiporter
ICIBICIF_00585 2.4e-49 ywnB S NAD(P)H-binding
ICIBICIF_00586 1.6e-290 gshF 6.3.2.2 H Belongs to the glutamate--cysteine ligase type 1 family
ICIBICIF_00587 2.2e-96 V VanZ like family
ICIBICIF_00588 4.4e-222 aspB 2.6.1.1, 2.6.1.14 E Aminotransferase
ICIBICIF_00589 9.5e-61 yneR
ICIBICIF_00590 1.9e-181 K Transcriptional regulator, LacI family
ICIBICIF_00591 3.2e-229 gntT EG Gluconate
ICIBICIF_00592 2.9e-287 gntK 2.7.1.12, 2.7.1.17 G Belongs to the FGGY kinase family
ICIBICIF_00593 1.5e-172 mutR K Transcriptional activator, Rgg GadR MutR family
ICIBICIF_00594 4.8e-88 3.6.3.6 P ATPase, P-type transporting, HAD superfamily, subfamily IC
ICIBICIF_00596 4.2e-80 copY K Copper transport repressor CopY TcrY
ICIBICIF_00597 1.5e-40
ICIBICIF_00598 8.8e-170 GK ROK family
ICIBICIF_00599 2.3e-130 1.14.12.17 C Oxidoreductase NAD-binding domain
ICIBICIF_00600 2.4e-311 ubiB S ABC1 family
ICIBICIF_00601 1.1e-103 wecD3 K Acetyltransferase (GNAT) family
ICIBICIF_00602 4.9e-69 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
ICIBICIF_00603 6.4e-55 crcB D Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ICIBICIF_00604 2.9e-54 crcB U Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ICIBICIF_00605 1.8e-56 arsR K Helix-turn-helix domain
ICIBICIF_00606 0.0 arsA 3.6.3.16 D Anion-transporting ATPase
ICIBICIF_00607 6e-233 arsB U Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ICIBICIF_00608 2.3e-30 arsD S Arsenical resistance operon trans-acting repressor ArsD
ICIBICIF_00609 2.2e-72 arsC 1.20.4.1 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ICIBICIF_00610 6.9e-101 K DNA-templated transcription, initiation
ICIBICIF_00612 0.0 N Uncharacterized conserved protein (DUF2075)
ICIBICIF_00613 0.0 alsS 2.2.1.6 EH Belongs to the TPP enzyme family
ICIBICIF_00614 2.2e-111 ybbL S ABC transporter, ATP-binding protein
ICIBICIF_00615 2.5e-133 ybbM S Uncharacterised protein family (UPF0014)
ICIBICIF_00616 1.1e-89 rmeB K transcriptional regulator, MerR family
ICIBICIF_00617 5.6e-29 yrfB C NADH:flavin oxidoreductase / NADH oxidase family
ICIBICIF_00618 7.8e-57 arsC 1.20.4.1 T Low molecular weight phosphotyrosine protein phosphatase
ICIBICIF_00621 1.2e-216 argE 3.5.1.18 E succinyl-diaminopimelate desuccinylase
ICIBICIF_00622 3e-110 guaD 3.5.4.3 F Amidohydrolase family
ICIBICIF_00623 3e-133 guaD 3.5.4.3 F Amidohydrolase family
ICIBICIF_00624 3.8e-226 aadAT EK Aminotransferase, class I
ICIBICIF_00625 1.2e-159 gshF 6.3.2.2 H Belongs to the glutamate--cysteine ligase type 1 family
ICIBICIF_00626 6.3e-143 ET Bacterial periplasmic substrate-binding proteins
ICIBICIF_00628 4.7e-218 I transferase activity, transferring acyl groups other than amino-acyl groups
ICIBICIF_00630 8.6e-96 padC Q Phenolic acid decarboxylase
ICIBICIF_00631 8.3e-99 padR K Virulence activator alpha C-term
ICIBICIF_00632 3.4e-79 ndk 2.7.4.6 F Belongs to the NDK family
ICIBICIF_00633 4.1e-55 S SNARE associated Golgi protein
ICIBICIF_00634 2.7e-238 N Uncharacterized conserved protein (DUF2075)
ICIBICIF_00635 0.0 dxs 2.2.1.7 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ICIBICIF_00637 7.8e-255 yifK E Amino acid permease
ICIBICIF_00639 8.8e-267 pipD E Dipeptidase
ICIBICIF_00640 1.2e-163 endA F DNA RNA non-specific endonuclease
ICIBICIF_00641 4.8e-165 fadB4 1.1.1.157 I 3-hydroxyacyl-CoA dehydrogenase
ICIBICIF_00642 0.0 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ICIBICIF_00643 6.3e-154 S Alpha/beta hydrolase of unknown function (DUF915)
ICIBICIF_00645 9.2e-228
ICIBICIF_00646 3.4e-194 V Beta-lactamase
ICIBICIF_00647 1.4e-89 pgpA 3.1.3.27 I Phosphatidylglycerophosphatase A
ICIBICIF_00648 9.1e-125 S membrane transporter protein
ICIBICIF_00649 4.3e-179 S AI-2E family transporter
ICIBICIF_00650 8.8e-215 phbA 2.3.1.9 I Belongs to the thiolase family
ICIBICIF_00651 4.1e-161 rssA S Phospholipase, patatin family
ICIBICIF_00652 7.5e-169 K LysR substrate binding domain
ICIBICIF_00653 0.0 1.3.5.4 C FAD binding domain
ICIBICIF_00654 9.8e-74 S Domain of unknown function (DUF4352)
ICIBICIF_00655 6.8e-114 yicL EG EamA-like transporter family
ICIBICIF_00656 2.8e-63
ICIBICIF_00659 5.7e-35
ICIBICIF_00660 4.1e-68 S pyridoxamine 5-phosphate
ICIBICIF_00661 2.8e-179 yobV1 K WYL domain
ICIBICIF_00662 1e-243 XK27_08635 S UPF0210 protein
ICIBICIF_00663 2.5e-40 gcvR T Belongs to the UPF0237 family
ICIBICIF_00664 3.7e-168 mccA 2.5.1.134, 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
ICIBICIF_00665 9.8e-211 metC 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
ICIBICIF_00666 4.4e-205 adh 1.1.1.1, 1.1.1.14 C Zinc-binding dehydrogenase
ICIBICIF_00667 1.7e-218 G Transporter, major facilitator family protein
ICIBICIF_00668 1.7e-276 menE 6.2.1.26 H Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily
ICIBICIF_00669 5.3e-158 menB 4.1.3.36 H Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ICIBICIF_00670 1.9e-54 ydiI Q Thioesterase superfamily
ICIBICIF_00671 1.4e-162 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
ICIBICIF_00673 4.8e-186 adhC 1.1.1.90 C Zn-dependent alcohol dehydrogenases, class III
ICIBICIF_00674 5.5e-94 citR K sugar-binding domain protein
ICIBICIF_00675 2.4e-137 citG 2.4.2.52, 2.7.7.61 H 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase
ICIBICIF_00676 6.1e-71 ydjP I Alpha/beta hydrolase family
ICIBICIF_00677 7.9e-108 L Integrase
ICIBICIF_00678 5.7e-45 K transcriptional regulator
ICIBICIF_00679 4.5e-26 C Flavodoxin
ICIBICIF_00680 2.1e-75 paiA 2.3.1.57 K Acetyltransferase (GNAT) domain
ICIBICIF_00681 4.2e-74 O OsmC-like protein
ICIBICIF_00682 1.3e-57 K Transcriptional regulator
ICIBICIF_00683 1.7e-162 proX M ABC transporter, substrate-binding protein, QAT family
ICIBICIF_00684 1.8e-108 proWZ P ABC transporter permease
ICIBICIF_00685 9.3e-141 proV E ABC transporter, ATP-binding protein
ICIBICIF_00686 6.6e-100 proW P ABC transporter, permease protein
ICIBICIF_00687 2.1e-182 C Zinc-binding dehydrogenase
ICIBICIF_00688 6.3e-196 bdhA 1.1.1.303, 1.1.1.4 C Zinc-binding dehydrogenase
ICIBICIF_00689 1.4e-223 4.4.1.8 E Aminotransferase, class I
ICIBICIF_00690 3.2e-180 pva3 3.5.1.24 M Linear amide C-N hydrolase, choloylglycine hydrolase family protein
ICIBICIF_00691 7.1e-203 xerS L Belongs to the 'phage' integrase family
ICIBICIF_00692 3.1e-62 ywkB S Membrane transport protein
ICIBICIF_00693 1.2e-96 icd 1.1.1.42 C Isocitrate/isopropylmalate dehydrogenase
ICIBICIF_00694 3.7e-111 icd 1.1.1.42 C Isocitrate/isopropylmalate dehydrogenase
ICIBICIF_00695 1.7e-151 pdxK 2.7.1.35 H Phosphomethylpyrimidine kinase
ICIBICIF_00696 1.7e-79 hmpT S ECF-type riboflavin transporter, S component
ICIBICIF_00697 1.1e-166 1.1.1.346 C Aldo keto reductase
ICIBICIF_00698 1.7e-160 S DUF218 domain
ICIBICIF_00701 6.3e-96 K Acetyltransferase (GNAT) domain
ICIBICIF_00702 1.1e-163 I alpha/beta hydrolase fold
ICIBICIF_00703 2.2e-125 S Phage minor capsid protein 2
ICIBICIF_00706 3.8e-215 2.6.1.1 E Aminotransferase
ICIBICIF_00707 1.5e-184 1.4.1.1, 4.3.1.12 E Ornithine cyclodeaminase/mu-crystallin family
ICIBICIF_00708 2.2e-38 EGP Sugar (and other) transporter
ICIBICIF_00709 5.5e-187 EGP Sugar (and other) transporter
ICIBICIF_00710 1.3e-96 apt 2.4.2.22, 2.4.2.7 F Phosphoribosyl transferase domain
ICIBICIF_00711 6.9e-84 S Fic/DOC family
ICIBICIF_00712 4.4e-71 yncA 2.3.1.18, 2.3.1.79 S Maltose acetyltransferase
ICIBICIF_00713 1.4e-102 lacA 2.3.1.18, 2.3.1.79 S Maltose acetyltransferase
ICIBICIF_00714 1.7e-198 ilvE 2.6.1.42 E Branched-chain amino acid aminotransferase
ICIBICIF_00715 2.3e-260 arcD E Amino acid permease
ICIBICIF_00716 1.2e-119 5.1.1.13 M racemase activity, acting on amino acids and derivatives
ICIBICIF_00717 7.9e-158 odh 1.5.1.28 C NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain
ICIBICIF_00718 7.7e-30 clcA P chloride
ICIBICIF_00719 2.7e-64 clcA P chloride
ICIBICIF_00720 5e-18 lmrB EGP Major facilitator Superfamily
ICIBICIF_00722 2.3e-243 yhjX P Major Facilitator Superfamily
ICIBICIF_00723 4.7e-120 S Protein of unknown function (DUF554)
ICIBICIF_00724 1.5e-255 rarA L recombination factor protein RarA
ICIBICIF_00726 0.0 oppD EP Psort location Cytoplasmic, score
ICIBICIF_00727 3e-242 codA 3.5.4.1 F cytosine deaminase
ICIBICIF_00728 4.7e-244 U Belongs to the purine-cytosine permease (2.A.39) family
ICIBICIF_00729 2.2e-81 yebR 1.8.4.14 T GAF domain-containing protein
ICIBICIF_00730 5.7e-94 ywnH 2.3.1.183 M Acetyltransferase (GNAT) domain
ICIBICIF_00731 3.4e-76 msrB 1.8.4.11, 1.8.4.12 O peptide methionine sulfoxide reductase
ICIBICIF_00732 2.3e-71 yqkB S Belongs to the HesB IscA family
ICIBICIF_00733 7.3e-172 ppaC 3.6.1.1 C inorganic pyrophosphatase
ICIBICIF_00734 5.2e-95 S Protein of unknown function (DUF1440)
ICIBICIF_00735 0.0 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
ICIBICIF_00736 0.0 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
ICIBICIF_00737 2.8e-103 plsY 2.3.1.15, 3.5.1.104 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
ICIBICIF_00738 4e-172 lacX 5.1.3.3 G Aldose 1-epimerase
ICIBICIF_00739 2.8e-154 D DNA integration
ICIBICIF_00740 0.0 topA 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ICIBICIF_00741 2e-163 dprA LU DNA protecting protein DprA
ICIBICIF_00742 2.3e-139 rnhB 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ICIBICIF_00743 3.8e-162 ylqF S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ICIBICIF_00744 3.1e-36 yozE S Belongs to the UPF0346 family
ICIBICIF_00745 7.1e-104 ypmS S Uncharacterized protein conserved in bacteria (DUF2140)
ICIBICIF_00746 1.1e-167 ypmR E lipolytic protein G-D-S-L family
ICIBICIF_00747 3.2e-107 cat S Bacterial transferase hexapeptide (six repeats)
ICIBICIF_00748 2.9e-218 1.1.1.399, 1.1.1.95 EH D-isomer specific 2-hydroxyacid dehydrogenase
ICIBICIF_00749 4e-153 DegV S EDD domain protein, DegV family
ICIBICIF_00750 1.2e-109 hlyIII S protein, hemolysin III
ICIBICIF_00751 8.7e-95 folA 1.5.1.3 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ICIBICIF_00752 2.1e-190 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ICIBICIF_00753 0.0 yfmR S ABC transporter, ATP-binding protein
ICIBICIF_00754 2.6e-222 cca 2.7.7.19, 2.7.7.72 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
ICIBICIF_00755 4.7e-165 xerD L Phage integrase, N-terminal SAM-like domain
ICIBICIF_00756 6.9e-234 S Tetratricopeptide repeat protein
ICIBICIF_00757 4.4e-40 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
ICIBICIF_00758 9.7e-247 der 1.1.1.399, 1.1.1.95 S GTPase that plays an essential role in the late steps of ribosome biogenesis
ICIBICIF_00759 5.8e-209 rpsA 1.17.7.4 J Ribosomal protein S1
ICIBICIF_00760 5.8e-118 cmk 1.17.7.4, 2.5.1.19, 2.7.1.26, 2.7.4.25, 2.7.7.2, 6.3.2.1 F Belongs to the cytidylate kinase family. Type 1 subfamily
ICIBICIF_00761 9.7e-31 M Lysin motif
ICIBICIF_00762 3.1e-278 recQ1 3.6.4.12 L ATP-dependent DNA helicase RecQ
ICIBICIF_00763 1.3e-198 ypbB 5.1.3.1 S Helix-turn-helix domain
ICIBICIF_00764 3.7e-81 U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
ICIBICIF_00765 1.1e-130 rluB 5.4.99.19, 5.4.99.21, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
ICIBICIF_00766 5e-102 scpB D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ICIBICIF_00767 3.9e-142 scpA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ICIBICIF_00768 3.4e-67 ribT K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
ICIBICIF_00769 5.3e-132 xerD D recombinase XerD
ICIBICIF_00770 1.6e-168 cvfB S S1 domain
ICIBICIF_00771 2.4e-267 pyk 2.7.1.40, 2.7.7.4 G Belongs to the pyruvate kinase family
ICIBICIF_00772 0.0 dnaE 2.7.7.7 L DNA polymerase
ICIBICIF_00774 6.6e-237 pepT 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
ICIBICIF_00775 4.5e-157 yqfO 3.5.4.16 S Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ICIBICIF_00776 3.5e-126 trmK 2.1.1.217 S SAM-dependent methyltransferase
ICIBICIF_00777 7.5e-118 ktrA P domain protein
ICIBICIF_00778 6.7e-227 ktrB P Potassium uptake protein
ICIBICIF_00779 1.5e-197 asd 1.2.1.11 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ICIBICIF_00780 1.9e-217 patA 2.6.1.1 E Aminotransferase
ICIBICIF_00781 5.6e-141 dapB 1.17.1.8 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
ICIBICIF_00782 9.2e-175 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ICIBICIF_00783 1.8e-220 hipO 3.5.1.47 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
ICIBICIF_00784 2.9e-72 dapD 2.3.1.117, 2.3.1.89 E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
ICIBICIF_00785 2.4e-253 lysA 4.1.1.19, 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
ICIBICIF_00786 6.5e-262 lysC 2.7.2.4 E Belongs to the aspartokinase family
ICIBICIF_00787 1.8e-179 dapF 5.1.1.7 E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ICIBICIF_00788 1.1e-169 apbE 2.7.1.180 H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
ICIBICIF_00789 1.3e-110 rimI 2.3.1.128 K Ribosomal-protein-alanine acetyltransferase
ICIBICIF_00790 1.2e-194 tsaD 2.3.1.234 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ICIBICIF_00792 2.7e-76 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
ICIBICIF_00793 1.6e-73 marR K Transcriptional regulator, MarR family
ICIBICIF_00794 4.4e-172 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ICIBICIF_00795 4.2e-34 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
ICIBICIF_00796 6.3e-171 fabD 2.3.1.39 I Malonyl CoA-acyl carrier protein transacylase
ICIBICIF_00797 2.7e-129 IQ reductase
ICIBICIF_00798 6e-230 fabF 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
ICIBICIF_00799 1.6e-63 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
ICIBICIF_00800 1.3e-75 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
ICIBICIF_00801 4.6e-263 accC 6.3.4.14, 6.4.1.2 I Acetyl-CoA carboxylase biotin carboxylase subunit
ICIBICIF_00802 1.5e-160 accD 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ICIBICIF_00803 1e-139 accA 2.1.3.15, 6.4.1.2 I alpha subunit
ICIBICIF_00804 1e-134 fabI 1.3.1.10, 1.3.1.9 I Enoyl- acyl-carrier-protein reductase NADH
ICIBICIF_00805 9.7e-92 bioY S BioY family
ICIBICIF_00806 5.6e-175 birA 6.3.4.15 H Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
ICIBICIF_00807 0.0 uup S ABC transporter, ATP-binding protein
ICIBICIF_00808 4.4e-115 rex K Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ICIBICIF_00809 7.4e-43 groS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ICIBICIF_00810 4.7e-291 groL O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
ICIBICIF_00811 0.0 ydaO E amino acid
ICIBICIF_00812 6.4e-38
ICIBICIF_00813 3.4e-112 yvyE 3.4.13.9 S YigZ family
ICIBICIF_00814 7.7e-252 comFA L Helicase C-terminal domain protein
ICIBICIF_00815 8e-128 comFC S Competence protein
ICIBICIF_00816 6.5e-96 hpf J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ICIBICIF_00817 0.0 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
ICIBICIF_00818 4.5e-202 prfB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ICIBICIF_00819 4.1e-53 KT PspC domain protein
ICIBICIF_00820 1.2e-47 yvlD S Mycobacterial 4 TMS phage holin, superfamily IV
ICIBICIF_00821 1e-176 hprK F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ICIBICIF_00822 9.6e-163 lgt 2.1.1.199 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ICIBICIF_00823 5.3e-184 gpsA 1.1.1.94 I Glycerol-3-phosphate dehydrogenase
ICIBICIF_00824 2.1e-171 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
ICIBICIF_00825 6.8e-147 mtnU 3.5.1.3 S Carbon-nitrogen hydrolase
ICIBICIF_00826 1.7e-226 mtnE 2.6.1.83 E Aminotransferase
ICIBICIF_00827 7.6e-188 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ICIBICIF_00828 1.5e-76 yphH S Cupin domain
ICIBICIF_00829 1.7e-131 trxB 1.8.1.9 C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
ICIBICIF_00830 1.3e-153 metAA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to
ICIBICIF_00831 5.2e-170 cysK 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
ICIBICIF_00832 5.5e-197 ilvE 2.6.1.42 E Branched-chain amino acid aminotransferase
ICIBICIF_00833 1.6e-171 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
ICIBICIF_00834 2.8e-137 cof S haloacid dehalogenase-like hydrolase
ICIBICIF_00835 0.0 pgm 5.4.2.2, 5.4.2.8 G Phosphoglucomutase phosphomannomutase, alpha beta alpha domain
ICIBICIF_00836 1.4e-113 yfbR S HD containing hydrolase-like enzyme
ICIBICIF_00838 0.0 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
ICIBICIF_00839 0.0 uvrA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
ICIBICIF_00840 7.6e-205
ICIBICIF_00841 2.1e-160 rapZ S Displays ATPase and GTPase activities
ICIBICIF_00842 1.7e-187 ybhK S Required for morphogenesis under gluconeogenic growth conditions
ICIBICIF_00843 1.9e-167 whiA K May be required for sporulation
ICIBICIF_00844 1.1e-50 tenA 3.5.99.2 K Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ICIBICIF_00845 6.4e-54 tenA 3.5.99.2 K Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ICIBICIF_00846 1.3e-102 clpP 3.4.21.92 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
ICIBICIF_00850 1e-15
ICIBICIF_00851 4.5e-191 gap 1.2.1.12 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
ICIBICIF_00852 6.6e-226 pgk 2.7.2.3, 5.3.1.1 F Belongs to the phosphoglycerate kinase family
ICIBICIF_00853 3.1e-144 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
ICIBICIF_00854 1e-248 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
ICIBICIF_00855 1.5e-253 yifK E Amino acid permease
ICIBICIF_00856 2.2e-290 clcA P chloride
ICIBICIF_00857 4.5e-33 secG U Preprotein translocase
ICIBICIF_00858 0.0 rnr J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
ICIBICIF_00859 2.9e-84 smpB J the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
ICIBICIF_00860 1.2e-108 yxjI
ICIBICIF_00861 2.8e-136 ung 3.2.2.27 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ICIBICIF_00862 2.4e-178 pta 2.3.1.8, 3.6.3.21 C phosphate acetyltransferase
ICIBICIF_00863 2.9e-81 ydiB 2.7.1.221, 5.1.1.1 O Hydrolase, P-loop family
ICIBICIF_00864 7.3e-89 K Acetyltransferase (GNAT) domain
ICIBICIF_00865 1.3e-101 dnaQ 2.7.7.7 L DNA polymerase III
ICIBICIF_00866 5.7e-166 murB 1.3.1.98 M Cell wall formation
ICIBICIF_00867 4.6e-149 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ICIBICIF_00868 7e-116 ybbR S YbbR-like protein
ICIBICIF_00869 1.1e-253 glmM 5.4.2.10 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ICIBICIF_00870 0.0 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
ICIBICIF_00871 1.5e-52
ICIBICIF_00872 7.1e-211 oatA I Acyltransferase
ICIBICIF_00873 5.3e-150 XK27_02985 S Sucrose-6F-phosphate phosphohydrolase
ICIBICIF_00874 1.3e-68 lytE M Lysin motif
ICIBICIF_00875 9.2e-160 MA20_14895 S Conserved hypothetical protein 698
ICIBICIF_00876 2.8e-168 K LysR substrate binding domain
ICIBICIF_00877 6.4e-131 manA 5.3.1.8 G mannose-6-phosphate isomerase
ICIBICIF_00878 6.6e-148 yitS S EDD domain protein, DegV family
ICIBICIF_00879 6.5e-90 racA K Domain of unknown function (DUF1836)
ICIBICIF_00880 2.3e-181 yfeX P Peroxidase
ICIBICIF_00881 8.9e-31 manL 2.7.1.191 G PTS system sorbose subfamily IIB component
ICIBICIF_00882 5.1e-122 manL 2.7.1.191 G PTS system sorbose subfamily IIB component
ICIBICIF_00883 4.6e-122 manY G PTS system
ICIBICIF_00884 3e-170 manN G system, mannose fructose sorbose family IID component
ICIBICIF_00885 1.6e-57 S Domain of unknown function (DUF956)
ICIBICIF_00886 9.7e-132 K response regulator
ICIBICIF_00887 1.3e-250 yclK 2.7.13.3 T Histidine kinase
ICIBICIF_00888 5.9e-152 glcU U sugar transport
ICIBICIF_00889 1.1e-23 L Helix-turn-helix domain
ICIBICIF_00890 2.6e-163 L PFAM Integrase catalytic region
ICIBICIF_00891 6.1e-105 ahpC 1.11.1.15 O Peroxiredoxin
ICIBICIF_00892 0.0 trxB2 1.8.1.9 C Thioredoxin domain
ICIBICIF_00893 1.6e-85 K GNAT family
ICIBICIF_00894 1.8e-122 XK27_08875 O PFAM peptidase M10A and M12B, matrixin and adamalysin
ICIBICIF_00895 4e-161 ytbE 1.1.1.346 S Aldo keto reductase
ICIBICIF_00896 1.8e-144 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
ICIBICIF_00897 7.4e-132 budA 4.1.1.5 H Belongs to the alpha-acetolactate decarboxylase family
ICIBICIF_00899 3.6e-57
ICIBICIF_00901 3.5e-08
ICIBICIF_00902 1.8e-78 K Winged helix DNA-binding domain
ICIBICIF_00903 0.0 lmrA V ABC transporter, ATP-binding protein
ICIBICIF_00904 0.0 yfiC V ABC transporter
ICIBICIF_00905 9.7e-194 ampC V Beta-lactamase
ICIBICIF_00906 2.9e-271 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ICIBICIF_00907 2.8e-48
ICIBICIF_00908 3.4e-140 cobQ S CobB/CobQ-like glutamine amidotransferase domain
ICIBICIF_00909 7.5e-263 murF 6.3.2.10, 6.3.2.13 M Domain of unknown function (DUF1727)
ICIBICIF_00910 3.2e-109 tdk 2.7.1.21 F thymidine kinase
ICIBICIF_00911 2.5e-155 prfA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ICIBICIF_00912 7.1e-158 prmB 2.1.1.297, 2.1.1.298 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
ICIBICIF_00913 6.8e-195 ywlC 2.7.7.87, 3.1.3.48 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
ICIBICIF_00914 7e-231 glyA 2.1.2.1 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ICIBICIF_00915 1.2e-114 upp 2.4.2.9 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ICIBICIF_00916 1.3e-183 yibE S overlaps another CDS with the same product name
ICIBICIF_00917 1.5e-122 yibF S overlaps another CDS with the same product name
ICIBICIF_00918 2.7e-217 pyrP F Permease
ICIBICIF_00919 5.8e-129 atpB C it plays a direct role in the translocation of protons across the membrane
ICIBICIF_00920 1.2e-16 atpE C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ICIBICIF_00921 3.7e-53 atpF C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ICIBICIF_00922 7.4e-92 atpH C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ICIBICIF_00923 4.7e-285 atpA 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ICIBICIF_00924 2.3e-165 atpG C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ICIBICIF_00925 4.4e-253 atpD 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ICIBICIF_00926 1.7e-67 atpC C Produces ATP from ADP in the presence of a proton gradient across the membrane
ICIBICIF_00927 2.8e-29 S Protein of unknown function (DUF1146)
ICIBICIF_00928 2.3e-218 murA 2.5.1.7 M EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
ICIBICIF_00929 7.7e-183 mbl D Cell shape determining protein MreB Mrl
ICIBICIF_00930 7.9e-32 S Protein of unknown function (DUF2969)
ICIBICIF_00931 6.4e-221 rodA D Belongs to the SEDS family
ICIBICIF_00933 5.3e-181 S Protein of unknown function (DUF2785)
ICIBICIF_00934 7.7e-216 ddl 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
ICIBICIF_00935 8.4e-151 2.3.1.19 K Helix-turn-helix XRE-family like proteins
ICIBICIF_00936 2.3e-81 usp6 T universal stress protein
ICIBICIF_00938 2e-236 rarA L recombination factor protein RarA
ICIBICIF_00939 1.5e-85 yueI S Protein of unknown function (DUF1694)
ICIBICIF_00940 3.3e-76 4.4.1.5 E Glyoxalase
ICIBICIF_00941 2.4e-133 S Membrane
ICIBICIF_00942 4.6e-149 S Uncharacterised 5xTM membrane BCR, YitT family COG1284
ICIBICIF_00943 1.7e-108 rpsD J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ICIBICIF_00944 6.4e-307 ezrA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
ICIBICIF_00945 1.1e-214 iscS2 2.8.1.7 E Aminotransferase class V
ICIBICIF_00946 2.5e-228 thiI 2.8.1.4 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ICIBICIF_00947 2.9e-211 EG GntP family permease
ICIBICIF_00948 2.3e-204 glxK 2.7.1.165 G Belongs to the glycerate kinase type-1 family
ICIBICIF_00949 3.4e-42 tpx 1.11.1.15 O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ICIBICIF_00950 1.8e-27 tpx 1.11.1.15 O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ICIBICIF_00951 0.0 valS 6.1.1.9 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
ICIBICIF_00952 1.9e-250 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
ICIBICIF_00953 2.5e-115 radC L DNA repair protein
ICIBICIF_00954 1.9e-181 mreB D cell shape determining protein MreB
ICIBICIF_00955 3.7e-146 mreC M Involved in formation and maintenance of cell shape
ICIBICIF_00956 6.6e-93 mreD M rod shape-determining protein MreD
ICIBICIF_00957 1.4e-108 glnP P ABC transporter permease
ICIBICIF_00958 4.8e-114 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
ICIBICIF_00959 4.1e-161 aatB ET ABC transporter substrate-binding protein
ICIBICIF_00960 7.3e-231 ymfF S Peptidase M16 inactive domain protein
ICIBICIF_00961 5.8e-252 ymfH S Peptidase M16
ICIBICIF_00962 7e-96 ymfM S Helix-turn-helix domain
ICIBICIF_00963 8.5e-102 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ICIBICIF_00964 1.9e-231 cinA 3.5.1.42 S Belongs to the CinA family
ICIBICIF_00965 1.1e-192 recA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ICIBICIF_00966 2.4e-204 rny S Endoribonuclease that initiates mRNA decay
ICIBICIF_00967 0.0 mutS L that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ICIBICIF_00968 0.0 mutL L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ICIBICIF_00969 1.1e-104 ruvA 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
ICIBICIF_00970 2.9e-190 ruvB 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
ICIBICIF_00971 2.2e-176 2.4.2.29 F queuine tRNA-ribosyltransferase activity
ICIBICIF_00972 5.5e-42 yajC U Preprotein translocase
ICIBICIF_00973 6.8e-181 nrnA 3.1.13.3, 3.1.3.7 S DHHA1 domain protein
ICIBICIF_00974 8.4e-233 cshB 3.6.4.13 JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
ICIBICIF_00975 0.0 alaS 6.1.1.7 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ICIBICIF_00976 1.2e-42 yrzL S Belongs to the UPF0297 family
ICIBICIF_00977 9.6e-74 yqgF J Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ICIBICIF_00978 5.7e-33 yrzB S Belongs to the UPF0473 family
ICIBICIF_00979 1.6e-163 rnhC 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ICIBICIF_00980 4.7e-91 cvpA S Colicin V production protein
ICIBICIF_00981 0.0 mutS2 L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
ICIBICIF_00982 1.5e-52 trxA O Belongs to the thioredoxin family
ICIBICIF_00983 1.2e-225 clcA_2 P Chloride transporter, ClC family
ICIBICIF_00984 3e-93 yslB S Protein of unknown function (DUF2507)
ICIBICIF_00985 1.4e-147 murI 3.6.1.66, 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
ICIBICIF_00986 1.1e-107 rdgB 3.6.1.66, 5.1.1.3 F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ICIBICIF_00987 1.5e-94 S Phosphoesterase
ICIBICIF_00988 1.7e-151 3.1.3.102, 3.1.3.104, 3.1.3.23 S haloacid dehalogenase-like hydrolase
ICIBICIF_00989 4e-156 ykuT M mechanosensitive ion channel
ICIBICIF_00990 9.2e-26 WQ51_05790 S protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ICIBICIF_00991 4.9e-70
ICIBICIF_00992 4.1e-214 pepQ 3.4.13.9 E Creatinase/Prolidase N-terminal domain
ICIBICIF_00993 2.2e-185 ccpA K catabolite control protein A
ICIBICIF_00994 3.6e-85
ICIBICIF_00995 1.8e-133 yebC K Transcriptional regulatory protein
ICIBICIF_00996 1.9e-83 mltD CBM50 M PFAM NLP P60 protein
ICIBICIF_00997 2.4e-88 ykcB M Dolichyl-phosphate-mannose-protein mannosyltransferase
ICIBICIF_00998 8.8e-225 ykcB M Dolichyl-phosphate-mannose-protein mannosyltransferase
ICIBICIF_00999 2.7e-177 comGA NU Type II IV secretion system protein
ICIBICIF_01000 1.7e-158 comGB NU type II secretion system
ICIBICIF_01001 1.1e-47 comGC U competence protein ComGC
ICIBICIF_01002 2.3e-15 NU general secretion pathway protein
ICIBICIF_01004 1e-14
ICIBICIF_01006 8.6e-159 ytxK 2.1.1.72 L N-6 DNA Methylase
ICIBICIF_01007 1.8e-223 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ICIBICIF_01008 5.3e-110 S Calcineurin-like phosphoesterase
ICIBICIF_01009 1.2e-97 yutD S Protein of unknown function (DUF1027)
ICIBICIF_01010 6.6e-142 nagD 2.7.1.25, 3.1.3.41 G Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
ICIBICIF_01011 5.7e-25 S Protein of unknown function (DUF1461)
ICIBICIF_01012 2.9e-103 dedA S SNARE-like domain protein
ICIBICIF_01013 1.7e-276 lacS G Transporter
ICIBICIF_01014 0.0 rafA 3.2.1.22 G alpha-galactosidase
ICIBICIF_01015 7.8e-180 galR K Transcriptional regulator
ICIBICIF_01016 6.9e-286 galT 2.7.7.12 G UDP-glucose--hexose-1-phosphate uridylyltransferase
ICIBICIF_01017 2.1e-224 galK 2.7.1.6 F Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ICIBICIF_01018 1.1e-183 celE 3.2.1.4 GH5,GH9 E GDSL-like Lipase/Acylhydrolase family
ICIBICIF_01019 5.4e-144 ptp3 3.1.3.48 T Tyrosine phosphatase family
ICIBICIF_01020 2.7e-96 yxkA S Phosphatidylethanolamine-binding protein
ICIBICIF_01021 6.9e-36
ICIBICIF_01022 6.6e-136 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
ICIBICIF_01023 7.4e-121 tcyB U Binding-protein-dependent transport system inner membrane component
ICIBICIF_01024 1.7e-140 tcyA ET Belongs to the bacterial solute-binding protein 3 family
ICIBICIF_01025 2e-52
ICIBICIF_01026 9e-170 MA20_03535 1.1.1.399, 1.1.1.95 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ICIBICIF_01027 1.7e-79 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
ICIBICIF_01028 6.9e-147 pnuC H nicotinamide mononucleotide transporter
ICIBICIF_01029 3.1e-92 ymdB S Macro domain protein
ICIBICIF_01030 0.0 pepO 3.4.24.71 O Peptidase family M13
ICIBICIF_01031 4.1e-229 pbuG S permease
ICIBICIF_01032 2.1e-45
ICIBICIF_01033 4.9e-213 S Putative metallopeptidase domain
ICIBICIF_01034 8e-205 3.1.3.1 S associated with various cellular activities
ICIBICIF_01035 1.3e-116 mpg 3.2.2.21 L Belongs to the DNA glycosylase MPG family
ICIBICIF_01036 6.8e-65 yeaO S Protein of unknown function, DUF488
ICIBICIF_01038 1.8e-124 yrkL S Flavodoxin-like fold
ICIBICIF_01039 1.5e-55
ICIBICIF_01040 2.2e-108 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX
ICIBICIF_01041 1e-96 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ICIBICIF_01042 2.4e-102
ICIBICIF_01043 9.5e-26
ICIBICIF_01044 6.3e-171 scrR K Transcriptional regulator, LacI family
ICIBICIF_01045 5.5e-172 acm2 3.2.1.17 NU Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
ICIBICIF_01046 2.6e-46 czrA K Transcriptional regulator, ArsR family
ICIBICIF_01047 1.8e-75 argR K Regulates arginine biosynthesis genes
ICIBICIF_01048 3.6e-120 devA 3.6.3.25 V ABC transporter, ATP-binding protein
ICIBICIF_01049 5e-158 hrtB V ABC transporter permease
ICIBICIF_01050 1.1e-107 ygfC K Bacterial regulatory proteins, tetR family
ICIBICIF_01051 2.4e-189 tdh 1.1.1.14 E Alcohol dehydrogenase GroES-like domain
ICIBICIF_01052 1.3e-282 mntH P H( )-stimulated, divalent metal cation uptake system
ICIBICIF_01053 2.2e-22
ICIBICIF_01054 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ICIBICIF_01055 5.7e-69 L nuclease
ICIBICIF_01056 5.8e-163 F DNA/RNA non-specific endonuclease
ICIBICIF_01057 2.1e-105 lepB 3.4.21.89 U Belongs to the peptidase S26 family
ICIBICIF_01058 3.1e-292 murE 6.3.2.13, 6.3.2.7 M Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ICIBICIF_01059 2e-291 murE 6.3.2.13, 6.3.2.7 M Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ICIBICIF_01060 0.0 asnB 6.3.5.4 E Asparagine synthase
ICIBICIF_01061 6.6e-220 lysP E amino acid
ICIBICIF_01062 7e-49 mscL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
ICIBICIF_01063 0.0 gidA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
ICIBICIF_01064 1.1e-253 mnmE S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ICIBICIF_01065 4.8e-154 jag S R3H domain protein
ICIBICIF_01066 3e-140 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
ICIBICIF_01067 1.4e-56 rnpA 3.1.26.5 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
ICIBICIF_01068 2.6e-14 rpmH J Belongs to the bacterial ribosomal protein bL34 family
ICIBICIF_01070 5.2e-248 dnaA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ICIBICIF_01071 1.1e-206 dnaN 2.7.7.7 L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
ICIBICIF_01072 2.2e-34 yaaA S S4 domain protein YaaA
ICIBICIF_01073 1.5e-203 recF L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ICIBICIF_01074 0.0 gyrB 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ICIBICIF_01075 0.0 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ICIBICIF_01076 3.6e-48 rpsF J Binds together with S18 to 16S ribosomal RNA
ICIBICIF_01077 6.4e-91 ssb L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
ICIBICIF_01078 2.1e-35 rpsR J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ICIBICIF_01079 0.0 yybT T signaling protein consisting of a modified GGDEF domain and a DHH domain
ICIBICIF_01080 1.2e-74 rplI J Binds to the 23S rRNA
ICIBICIF_01081 6.3e-244 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
ICIBICIF_01082 1.4e-207 lmrP E Major Facilitator Superfamily
ICIBICIF_01083 6.3e-50
ICIBICIF_01086 4.4e-129 K response regulator
ICIBICIF_01087 0.0 vicK 2.7.13.3 T Histidine kinase
ICIBICIF_01088 6.7e-240 yycH S YycH protein
ICIBICIF_01089 8e-143 yycI S YycH protein
ICIBICIF_01090 6e-154 vicX 3.1.26.11 S domain protein
ICIBICIF_01091 3e-208 htrA 3.4.21.107 O serine protease
ICIBICIF_01092 3e-81 rlmH 2.1.1.177 J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ICIBICIF_01093 5.7e-71 K Transcriptional regulator
ICIBICIF_01094 1.1e-175 malR K Transcriptional regulator, LacI family
ICIBICIF_01095 2.8e-249 malT G Major Facilitator
ICIBICIF_01096 0.0 mapA 2.4.1.8 GH65 G hydrolase, family 65, central catalytic
ICIBICIF_01097 1.4e-116 pgmB 2.4.1.64, 3.1.3.12, 3.2.1.28, 5.4.2.6 GH37,GH65 S beta-phosphoglucomutase
ICIBICIF_01098 1.8e-15 natA S ABC transporter, ATP-binding protein
ICIBICIF_01099 8.8e-16 natA S ABC transporter, ATP-binding protein
ICIBICIF_01100 6.2e-190 pacA 3.5.1.24 M Linear amide C-N hydrolase, choloylglycine hydrolase family protein
ICIBICIF_01101 1.2e-182 D Alpha beta
ICIBICIF_01102 4.1e-181 ldhD 1.1.1.28 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ICIBICIF_01103 1.7e-218 patA 2.6.1.1 E Aminotransferase
ICIBICIF_01104 2.7e-35
ICIBICIF_01105 0.0 clpL O associated with various cellular activities
ICIBICIF_01106 8.8e-281 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ICIBICIF_01107 0.0 rexB 3.1.21.3, 3.6.4.12 L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' - 3' nuclease activity
ICIBICIF_01108 0.0 addA 3.6.4.12 L ATP-dependent helicase nuclease subunit A
ICIBICIF_01109 1.3e-162 yvgN C Aldo keto reductase
ICIBICIF_01110 1.9e-292 glpQ 3.1.4.46 C phosphodiesterase
ICIBICIF_01111 1.7e-65 arsC 1.20.4.1 P Belongs to the ArsC family
ICIBICIF_01112 2.7e-189 ybhR V ABC transporter
ICIBICIF_01113 6.6e-128 ybhF_2 V AAA domain, putative AbiEii toxin, Type IV TA system
ICIBICIF_01114 2.4e-93 K transcriptional regulator
ICIBICIF_01115 7.4e-167 guaC 1.1.1.205, 1.7.1.7 F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
ICIBICIF_01116 6e-249 purA 6.3.4.4 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ICIBICIF_01117 3.7e-257 gabD 1.2.1.16, 1.2.1.20, 1.2.1.79 C Belongs to the aldehyde dehydrogenase family
ICIBICIF_01118 4.2e-95 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ICIBICIF_01119 2.4e-130 pyrF 4.1.1.23 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
ICIBICIF_01120 1.1e-115 pyrE 2.4.2.10, 4.1.1.23 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ICIBICIF_01121 6.9e-47
ICIBICIF_01122 3.2e-273 tagE3 2.4.1.52 GT4 M Glycosyl transferases group 1
ICIBICIF_01123 3.5e-261 tagE2 2.4.1.52 GT4 M Poly(Glycerol-phosphate) alpha-glucosyltransferase
ICIBICIF_01124 1.2e-149 metQ1 P Belongs to the nlpA lipoprotein family
ICIBICIF_01125 6.1e-191 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ICIBICIF_01126 1.2e-97 metI P ABC transporter permease
ICIBICIF_01127 2.2e-218 argE 3.5.1.18 E succinyl-diaminopimelate desuccinylase
ICIBICIF_01128 4.4e-245 rumA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ICIBICIF_01129 1e-15 brnQ U Component of the transport system for branched-chain amino acids
ICIBICIF_01130 9.2e-122 iolS C Aldo keto reductase
ICIBICIF_01131 1.1e-242 dltD M Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
ICIBICIF_01132 1.2e-35 dltC 6.1.1.13 J Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
ICIBICIF_01133 1e-237 dltB M MBOAT, membrane-bound O-acyltransferase family
ICIBICIF_01134 8.3e-298 dltA 6.1.1.13 H Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
ICIBICIF_01136 8.7e-220 sbcD L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
ICIBICIF_01137 0.0 sbcC L Putative exonuclease SbcCD, C subunit
ICIBICIF_01138 5.7e-231 serS 6.1.1.11 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ICIBICIF_01140 3.2e-189 trpS 6.1.1.2 J Belongs to the class-I aminoacyl-tRNA synthetase family
ICIBICIF_01142 4.7e-226 glnP P ABC transporter
ICIBICIF_01143 2.2e-134 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
ICIBICIF_01144 3.1e-251 cycA E Amino acid permease
ICIBICIF_01145 7.1e-212 nupG F Nucleoside transporter
ICIBICIF_01146 2.2e-144 rihC 3.2.2.1 F Nucleoside
ICIBICIF_01147 3.1e-133 rsmG 2.1.1.170 J Specifically methylates the N7 position of a guanine in 16S rRNA
ICIBICIF_01148 3.3e-156 noc K Belongs to the ParB family
ICIBICIF_01149 7.3e-147 spo0J K Belongs to the ParB family
ICIBICIF_01150 7.9e-31 yyzM S Bacterial protein of unknown function (DUF951)
ICIBICIF_01151 4.4e-200 ychF J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
ICIBICIF_01152 9.1e-136 XK27_01040 S Protein of unknown function (DUF1129)
ICIBICIF_01153 4.5e-208 guaB 1.1.1.205 F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
ICIBICIF_01154 9e-160 brpA K Cell envelope-like function transcriptional attenuator common domain protein
ICIBICIF_01155 5e-134 epsB M biosynthesis protein
ICIBICIF_01156 5.5e-114 ywqD 2.7.10.1 D Capsular exopolysaccharide family
ICIBICIF_01157 3.6e-140 ywqE 3.1.3.48 GM PHP domain protein
ICIBICIF_01158 4.7e-90 capM M Bacterial sugar transferase
ICIBICIF_01159 7.6e-88 lsgF M Glycosyl transferase family 2
ICIBICIF_01161 1.2e-49 pglI 2.4.1.293 GT2 M Glycosyltransferase like family 2
ICIBICIF_01162 2.7e-55 S Stealth protein CR1, conserved region 1
ICIBICIF_01163 1.6e-85 S Polysaccharide biosynthesis protein
ICIBICIF_01164 5.1e-09 S Domain of unknown function DUF1829
ICIBICIF_01165 8.2e-93 S Cupin superfamily (DUF985)
ICIBICIF_01166 1.8e-122 K response regulator
ICIBICIF_01167 2.7e-208 hpk31 2.7.13.3 T Histidine kinase
ICIBICIF_01168 5e-203 dacA 3.4.16.4 M Belongs to the peptidase S11 family
ICIBICIF_01169 1.2e-149 azlC E AzlC protein
ICIBICIF_01170 8.9e-61 azlD S branched-chain amino acid
ICIBICIF_01171 1.3e-60 ydeN S Serine hydrolase
ICIBICIF_01172 3.7e-229 cfa 2.1.1.317, 2.1.1.79 M cyclopropane-fatty-acyl-phospholipid synthase
ICIBICIF_01173 3.1e-10 K transcriptional regulator
ICIBICIF_01174 3.1e-163 K AI-2E family transporter
ICIBICIF_01175 0.0 fhs 6.3.4.3 F Belongs to the formate--tetrahydrofolate ligase family
ICIBICIF_01176 1.5e-80 purE 5.4.99.18 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ICIBICIF_01177 2.2e-215 purK 6.3.4.18 F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ICIBICIF_01178 3.3e-255 purB 4.3.2.2 F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ICIBICIF_01179 2.1e-172 hrpQ 4.6.1.1 T histone H2A K63-linked ubiquitination
ICIBICIF_01180 4.4e-246 S response to antibiotic
ICIBICIF_01181 1.3e-31 nagZ 3.2.1.52 G Glycosyl hydrolase family 3 N terminal domain
ICIBICIF_01183 5.5e-19 K HxlR-like helix-turn-helix
ICIBICIF_01184 2.5e-135 purC 4.1.1.21, 4.3.2.2, 6.3.2.6 F Belongs to the SAICAR synthetase family
ICIBICIF_01185 1.2e-36 purS 6.3.2.6, 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ICIBICIF_01186 1.6e-128 purQ 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ICIBICIF_01187 0.0 purL 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ICIBICIF_01188 5.7e-280 purF 2.4.2.14 F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ICIBICIF_01189 4.3e-197 purM 6.3.3.1, 6.3.4.13 F Phosphoribosylformylglycinamidine cyclo-ligase
ICIBICIF_01190 6e-108 purN 2.1.2.2 F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ICIBICIF_01191 8e-293 purH 2.1.2.3, 3.5.4.10 F Bifunctional purine biosynthesis protein PurH
ICIBICIF_01192 7.6e-241 purD 6.3.4.13 F Belongs to the GARS family
ICIBICIF_01193 1.6e-131 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ICIBICIF_01194 1e-223 patA 2.6.1.1, 2.6.1.57 E Aminotransferase
ICIBICIF_01195 1.1e-178
ICIBICIF_01196 1.1e-46 silP 1.9.3.1, 3.6.3.54 S Cupredoxin-like domain
ICIBICIF_01197 7.3e-52 silP 1.9.3.1, 3.6.3.54 S Cupredoxin-like domain
ICIBICIF_01198 0.0 copA 3.6.3.54 P P-type ATPase
ICIBICIF_01199 4.9e-30 EGP Major facilitator Superfamily
ICIBICIF_01200 4.7e-90 2.4.2.6 F nucleoside 2-deoxyribosyltransferase
ICIBICIF_01201 3.8e-16
ICIBICIF_01202 6e-12 S Transglycosylase associated protein
ICIBICIF_01203 1e-69 S Asp23 family, cell envelope-related function
ICIBICIF_01204 2.2e-86
ICIBICIF_01205 3.8e-207 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
ICIBICIF_01206 0.0 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
ICIBICIF_01207 0.0 glyS 6.1.1.14 J Glycyl-tRNA synthetase beta subunit
ICIBICIF_01208 4.9e-187 glyQ 6.1.1.14 J glycyl-tRNA synthetase alpha subunit
ICIBICIF_01209 2.9e-156 recO L Involved in DNA repair and RecF pathway recombination
ICIBICIF_01210 8.7e-170 era S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ICIBICIF_01211 1e-66 dgkA 2.7.1.107, 2.7.1.66 M Diacylglycerol kinase
ICIBICIF_01212 1.5e-80 ybeY 2.6.99.2, 3.5.4.5 S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ICIBICIF_01213 1.1e-178 phoH T phosphate starvation-inducible protein PhoH
ICIBICIF_01214 1.2e-71 yqeY S YqeY-like protein
ICIBICIF_01215 9.7e-23 rpsU J Belongs to the bacterial ribosomal protein bS21 family
ICIBICIF_01216 1.9e-129 yfeJ 6.3.5.2 F glutamine amidotransferase
ICIBICIF_01217 0.0 aspS 6.1.1.12 J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
ICIBICIF_01218 1e-248 hisS 6.1.1.21 J histidyl-tRNA synthetase
ICIBICIF_01219 2.1e-196 6.3.1.20 H Lipoate-protein ligase
ICIBICIF_01220 3.7e-174 lytH 3.5.1.28 M Ami_3
ICIBICIF_01221 3.4e-168 yniA G Phosphotransferase enzyme family
ICIBICIF_01222 4.6e-174 mmuM 1.5.1.20, 2.1.1.10 H homocysteine S-methyltransferase
ICIBICIF_01223 3.7e-244 mmuP E amino acid
ICIBICIF_01224 2.2e-159 metAA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to
ICIBICIF_01225 2.8e-213 hom1 1.1.1.3 E Homoserine dehydrogenase
ICIBICIF_01227 2.7e-137 IQ KR domain
ICIBICIF_01228 3.1e-153 cjaA ET ABC transporter substrate-binding protein
ICIBICIF_01229 1.1e-135 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
ICIBICIF_01230 2.2e-93 P ABC transporter permease
ICIBICIF_01231 9.3e-113 papP P ABC transporter, permease protein
ICIBICIF_01233 1.1e-150 ET Bacterial periplasmic substrate-binding proteins
ICIBICIF_01234 1.9e-108 yxeN U ABC transporter, permease protein
ICIBICIF_01235 1.6e-72 P Binding-protein-dependent transport system inner membrane component
ICIBICIF_01236 2.2e-134 tcyN 3.6.3.21 E ABC transporter
ICIBICIF_01237 2e-199 4.1.1.37 H Uroporphyrinogen decarboxylase (URO-D)
ICIBICIF_01239 3.3e-211 metB 2.5.1.48, 4.4.1.8 E Cys/Met metabolism PLP-dependent enzyme
ICIBICIF_01240 2.3e-218 metC1 2.5.1.48, 4.4.1.8 E cystathionine
ICIBICIF_01241 3.5e-85 slyA K Transcriptional regulator
ICIBICIF_01242 2.4e-77 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
ICIBICIF_01243 0.0 relA 2.7.6.5 KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ICIBICIF_01244 4.4e-58
ICIBICIF_01245 1.3e-134 rsmE 2.1.1.193 J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
ICIBICIF_01246 1.8e-181 prmA J Ribosomal protein L11 methyltransferase
ICIBICIF_01247 1.2e-54
ICIBICIF_01249 1.5e-172 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
ICIBICIF_01250 7.1e-97 S integral membrane protein
ICIBICIF_01252 6e-35 aes I Carboxylesterase family
ICIBICIF_01253 2.1e-33 aes I Hydrolase, alpha beta domain protein
ICIBICIF_01255 1.1e-36 S CRISPR-associated protein (Cas_Csn2)
ICIBICIF_01256 3.2e-34 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ICIBICIF_01257 1.9e-92 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ICIBICIF_01258 0.0 cas9 L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
ICIBICIF_01259 0.0 M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ICIBICIF_01260 5.6e-138 thiM 2.7.1.50 H Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ICIBICIF_01261 2.7e-143 thiD 2.5.1.3, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Phosphomethylpyrimidine kinase
ICIBICIF_01262 1.3e-111 thiE 2.5.1.3 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
ICIBICIF_01263 1.5e-149 thiD 2.5.1.3, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Phosphomethylpyrimidine kinase
ICIBICIF_01264 2.3e-67 psiE S Phosphate-starvation-inducible E
ICIBICIF_01265 2.9e-38 V CAAX protease self-immunity
ICIBICIF_01266 3.9e-98 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ICIBICIF_01267 5.5e-158 P Belongs to the nlpA lipoprotein family
ICIBICIF_01268 8.4e-104 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ICIBICIF_01269 1.6e-115 S Protein of unknown function (DUF554)
ICIBICIF_01270 8.2e-100 P Cadmium resistance transporter
ICIBICIF_01271 1.2e-219 iscS 2.8.1.7 E Aminotransferase class V
ICIBICIF_01272 2.8e-28 S ABC-type transport system involved in multi-copper enzyme maturation permease component
ICIBICIF_01273 7.8e-52 T Transcriptional regulatory protein, C terminal
ICIBICIF_01274 1.6e-63 T His Kinase A (phosphoacceptor) domain
ICIBICIF_01275 7.2e-54 C FMN binding
ICIBICIF_01276 2.6e-202 ribD 1.1.1.193, 3.5.4.26 H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ICIBICIF_01277 9.1e-107 ribE 2.5.1.9, 3.5.4.25, 4.1.99.12 H Riboflavin synthase
ICIBICIF_01278 1.3e-226 ribBA 3.5.4.25, 4.1.99.12 H Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate
ICIBICIF_01279 5.1e-81 ribH 2.5.1.78 H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
ICIBICIF_01280 9.3e-80 K 2 iron, 2 sulfur cluster binding
ICIBICIF_01281 7.1e-269 K COG COG0846 NAD-dependent protein deacetylases, SIR2 family
ICIBICIF_01282 4.1e-220 serA 1.1.1.399, 1.1.1.95 EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ICIBICIF_01283 8.3e-204 serC 2.6.1.52 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ICIBICIF_01284 9.3e-112 C aldo keto reductase
ICIBICIF_01285 1.9e-112 3.1.3.73 G phosphoglycerate mutase
ICIBICIF_01286 3.3e-09
ICIBICIF_01287 0.0 lepA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
ICIBICIF_01288 5.1e-201 hisC 2.6.1.9 E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ICIBICIF_01289 9.9e-52 hisE 3.5.4.19, 3.6.1.31, 5.3.1.16 E phosphoribosyl-ATP diphosphatase activity
ICIBICIF_01290 8.5e-56 hisI 3.5.4.19, 3.5.4.25, 3.6.1.31, 5.3.1.16 E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ICIBICIF_01291 3.6e-140 hisF 3.5.4.19, 3.6.1.31 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
ICIBICIF_01292 7.8e-129 hisA 5.3.1.16 E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ICIBICIF_01293 1.9e-80 hisH E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ICIBICIF_01294 2.8e-48 hisB 1.1.1.23, 2.6.1.9, 3.1.3.15, 4.2.1.19 E imidazoleglycerol-phosphate dehydratase
ICIBICIF_01295 4.1e-40 hisB 1.1.1.23, 2.6.1.9, 3.1.3.15, 4.2.1.19 E imidazoleglycerol-phosphate dehydratase
ICIBICIF_01296 2.3e-229 hisD 1.1.1.23, 1.1.1.308 E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ICIBICIF_01297 3.7e-108 hisG 2.4.2.17 F Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
ICIBICIF_01298 5.4e-217 hisZ 2.4.2.17, 6.1.1.21 E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ICIBICIF_01299 3.4e-168 hisK 3.1.3.15 E Histidinol phosphate phosphatase, HisJ
ICIBICIF_01300 3.2e-50 hisF 3.5.4.19, 3.6.1.31 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
ICIBICIF_01301 1.6e-08 hisF 3.5.4.19, 3.6.1.31 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
ICIBICIF_01302 2.4e-53 hisH E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ICIBICIF_01304 1.1e-177 dnaJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
ICIBICIF_01305 0.0 dnaK O Heat shock 70 kDa protein
ICIBICIF_01306 2.2e-57 grpE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ICIBICIF_01307 1.3e-190 hrcA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
ICIBICIF_01308 5.4e-62
ICIBICIF_01309 2.7e-224 dhaT 1.1.1.1, 1.1.1.202 C Dehydrogenase
ICIBICIF_01310 4.6e-09
ICIBICIF_01311 4.1e-157 uvrX 2.7.7.7 L Belongs to the DNA polymerase type-Y family
ICIBICIF_01312 9.4e-178 K Transcriptional regulator, LacI family
ICIBICIF_01313 0.0 malL 3.2.1.10 GH13 G Alpha amylase, catalytic domain protein
ICIBICIF_01314 1.9e-253 G Major Facilitator
ICIBICIF_01316 1.4e-248 EGP Major facilitator Superfamily
ICIBICIF_01317 1.6e-182 ribF 2.7.1.26, 2.7.7.2 H Belongs to the ribF family
ICIBICIF_01318 2e-166 truB 5.4.99.25 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ICIBICIF_01319 3.6e-58 rbfA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ICIBICIF_01320 0.0 infB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ICIBICIF_01321 3.2e-50 ylxQ J ribosomal protein
ICIBICIF_01322 1.4e-47 ylxR K Protein of unknown function (DUF448)
ICIBICIF_01323 8.3e-224 nusA K Participates in both transcription termination and antitermination
ICIBICIF_01324 3.3e-83 rimP J Required for maturation of 30S ribosomal subunits
ICIBICIF_01325 0.0 carB 6.3.5.5 F Carbamoyl-phosphate synthase
ICIBICIF_01326 8.9e-206 carA 6.3.5.5 F Carbamoyl-phosphate synthetase glutamine chain
ICIBICIF_01327 1e-195 argC 1.2.1.38 E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ICIBICIF_01328 6.5e-152 argJ 2.3.1.1, 2.3.1.35, 2.7.2.8 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ICIBICIF_01329 3.2e-42 argJ 2.3.1.1, 2.3.1.35, 2.7.2.8 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ICIBICIF_01330 8e-137 argB 2.7.2.8 F Belongs to the acetylglutamate kinase family. ArgB subfamily
ICIBICIF_01331 9.2e-217 argD 2.6.1.11, 2.6.1.17 E acetylornithine
ICIBICIF_01332 0.0 polC 2.7.7.7 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ICIBICIF_01333 0.0 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
ICIBICIF_01334 5e-232 rseP 3.4.21.107, 3.4.21.116 M zinc metalloprotease
ICIBICIF_01335 2.3e-134 cdsA 2.7.7.41 I Belongs to the CDS family
ICIBICIF_01336 1.3e-142 uppS 2.5.1.31 H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ICIBICIF_01337 4.1e-93 frr J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
ICIBICIF_01338 7e-130 pyrH 2.7.4.22 F Catalyzes the reversible phosphorylation of UMP to UDP
ICIBICIF_01339 4.9e-154 tsf J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ICIBICIF_01340 5e-142 rpsB J Belongs to the universal ribosomal protein uS2 family
ICIBICIF_01341 2.3e-47 yazA L GIY-YIG catalytic domain protein
ICIBICIF_01342 8e-137 yabB 2.1.1.223 L Methyltransferase small domain
ICIBICIF_01343 3.3e-115 plsC 2.3.1.51 I Acyltransferase
ICIBICIF_01344 2.7e-27 yneF S Uncharacterised protein family (UPF0154)
ICIBICIF_01345 9.2e-37 ynzC S UPF0291 protein
ICIBICIF_01346 4.2e-115 lexA 3.4.21.88 K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ICIBICIF_01347 9.4e-217 mvaS 2.3.3.10 I Hydroxymethylglutaryl-CoA synthase
ICIBICIF_01348 1e-53 lutA C Cysteine-rich domain
ICIBICIF_01349 3.3e-64 3.4.21.88 K Peptidase S24-like
ICIBICIF_01350 4.8e-13
ICIBICIF_01352 5.7e-103 kcsA P Ion transport protein
ICIBICIF_01353 5.5e-34 S Short C-terminal domain
ICIBICIF_01354 5.3e-26 yitW S Iron-sulfur cluster assembly protein
ICIBICIF_01355 9.3e-92 sdaAA 4.3.1.17 E L-serine dehydratase, iron-sulfur-dependent, alpha subunit
ICIBICIF_01356 2.8e-64 sdaAB 4.3.1.17 E Serine dehydratase beta chain
ICIBICIF_01359 0.0 nplT 3.2.1.133, 3.2.1.135, 3.2.1.54 GH13 G Belongs to the glycosyl hydrolase 13 family
ICIBICIF_01360 2.4e-253 G Major Facilitator Superfamily
ICIBICIF_01362 5.1e-89
ICIBICIF_01363 1.3e-78 F Nucleoside 2-deoxyribosyltransferase
ICIBICIF_01364 3.3e-183 scrR3 K Transcriptional regulator, LacI family
ICIBICIF_01365 3e-14
ICIBICIF_01366 9.8e-16 hbd2 1.1.1.157 I 3-hydroxyacyl-CoA dehydrogenase
ICIBICIF_01368 1.4e-12 S CHY zinc finger
ICIBICIF_01371 0.0 asnB 6.3.5.4 E Aluminium induced protein
ICIBICIF_01373 5.4e-190 EGP Major facilitator Superfamily
ICIBICIF_01376 1e-104 S Bacterial transferase hexapeptide (six repeats)
ICIBICIF_01377 6.2e-117 IQ Enoyl-(Acyl carrier protein) reductase
ICIBICIF_01378 9.7e-200 gldA 1.1.1.6 C dehydrogenase
ICIBICIF_01379 1.3e-16 xre K Helix-turn-helix domain
ICIBICIF_01380 2.1e-51 S Sugar efflux transporter for intercellular exchange
ICIBICIF_01381 3e-56 1.14.99.57 S Antibiotic biosynthesis monooxygenase
ICIBICIF_01382 4.6e-45 S Protein conserved in bacteria
ICIBICIF_01383 8.9e-98 ywrO S Flavodoxin-like fold
ICIBICIF_01384 2.9e-43 adhR K helix_turn_helix, mercury resistance
ICIBICIF_01385 1.1e-152 tesE Q hydratase
ICIBICIF_01386 8.6e-187 ldhA 1.1.1.28 C Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ICIBICIF_01387 5.6e-62 S Domain of unknown function (DUF4440)
ICIBICIF_01388 2.4e-95 apt 2.4.2.22, 2.4.2.7 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ICIBICIF_01389 0.0 recJ L Single-stranded-DNA-specific exonuclease RecJ
ICIBICIF_01390 1.9e-155 XK27_05435 1.1.1.100 S Belongs to the short-chain dehydrogenases reductases (SDR) family
ICIBICIF_01391 8.3e-176 rnz 3.1.26.11 J Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
ICIBICIF_01392 6.7e-248 obg S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ICIBICIF_01393 0.0 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
ICIBICIF_01394 3.3e-135 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
ICIBICIF_01396 8.3e-53 MA20_27270 S mazG nucleotide pyrophosphohydrolase
ICIBICIF_01397 2.3e-107 engB D Necessary for normal cell division and for the maintenance of normal septation
ICIBICIF_01398 1.5e-233 clpX O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ICIBICIF_01399 5.7e-215 tig D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
ICIBICIF_01400 3.3e-225 tuf J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ICIBICIF_01401 1.2e-163 S Tetratricopeptide repeat
ICIBICIF_01402 0.0 rnjB J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ICIBICIF_01403 4.6e-42 rpsO J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ICIBICIF_01404 2.3e-35 rpsT J Binds directly to 16S ribosomal RNA
ICIBICIF_01405 1.8e-184 holA 2.7.7.7 L DNA polymerase III delta subunit
ICIBICIF_01406 0.0 comEC S Competence protein ComEC
ICIBICIF_01407 3.4e-88 comEB 3.5.4.12 F ComE operon protein 2
ICIBICIF_01408 3.8e-90 comEA L Competence protein ComEA
ICIBICIF_01409 1.9e-197 ylbL T Belongs to the peptidase S16 family
ICIBICIF_01410 9.6e-89 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ICIBICIF_01411 1.3e-99 rsmD 2.1.1.171 L RNA methyltransferase, RsmD family
ICIBICIF_01412 3e-47 ylbG S Uncharacterized protein conserved in bacteria (DUF2129)
ICIBICIF_01413 1.4e-215 ftsW D Belongs to the SEDS family
ICIBICIF_01414 0.0 typA T GTP-binding protein TypA
ICIBICIF_01415 5.3e-136 suhB 3.1.3.25 G Belongs to the inositol monophosphatase superfamily
ICIBICIF_01416 2.4e-49 yktA S Belongs to the UPF0223 family
ICIBICIF_01417 7.5e-103 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
ICIBICIF_01418 1.2e-74
ICIBICIF_01419 2.2e-31 ykzG S Belongs to the UPF0356 family
ICIBICIF_01420 9e-189 ytlR 2.7.1.91 I Diacylglycerol kinase catalytic
ICIBICIF_01421 4.2e-74 spx4 1.20.4.1 P ArsC family
ICIBICIF_01422 0.0 recD 3.1.11.5 L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
ICIBICIF_01423 7.1e-124 S Repeat protein
ICIBICIF_01424 4.1e-121 pgm6 5.4.2.11, 5.4.2.12 G phosphoglycerate mutase
ICIBICIF_01425 4e-170 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
ICIBICIF_01426 3e-306 S amidohydrolase
ICIBICIF_01427 2.9e-223 mnmA 2.8.1.13 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
ICIBICIF_01428 3.4e-58 XK27_04120 S Putative amino acid metabolism
ICIBICIF_01429 4.6e-126 mtnN 3.2.2.9 E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ICIBICIF_01431 2.7e-97 nudF 3.6.1.13 L ADP-ribose pyrophosphatase
ICIBICIF_01432 3.4e-32 cspB K Cold shock protein
ICIBICIF_01433 0.0 ileS 6.1.1.5 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ICIBICIF_01435 4.8e-112 divIVA D DivIVA domain protein
ICIBICIF_01436 2.9e-145 ylmH S S4 domain protein
ICIBICIF_01437 1.2e-40 yggT S YGGT family
ICIBICIF_01438 2.1e-74 sepF D Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
ICIBICIF_01439 3.8e-219 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ICIBICIF_01440 3.2e-224 ftsA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
ICIBICIF_01441 1.3e-148 divIB D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
ICIBICIF_01442 2.8e-202 murG 2.4.1.227, 6.3.2.8 GT28 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ICIBICIF_01443 4.3e-261 murD 6.3.2.9 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ICIBICIF_01444 9.1e-178 mraY 2.7.8.13 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ICIBICIF_01445 0.0 ftsI 3.4.16.4 M Penicillin-binding Protein
ICIBICIF_01446 7e-09 ftsL D Cell division protein FtsL
ICIBICIF_01447 1.1e-172 rsmH 2.1.1.199 J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
ICIBICIF_01448 5.6e-79 mraZ K Belongs to the MraZ family
ICIBICIF_01449 5.8e-58
ICIBICIF_01450 1.2e-07 S Protein of unknown function (DUF4044)
ICIBICIF_01451 0.0 ftsK D Belongs to the FtsK SpoIIIE SftA family
ICIBICIF_01452 1.5e-94 trmL 2.1.1.207 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
ICIBICIF_01453 7.4e-163 rrmA 2.1.1.187 H Methyltransferase
ICIBICIF_01454 8.8e-195 pgl 3.1.1.31 G Lactonase, 7-bladed beta-propeller
ICIBICIF_01455 8.2e-173 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 G Responsible for synthesis of pseudouridine from uracil
ICIBICIF_01456 1e-153 nadK 2.7.1.23 F Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ICIBICIF_01457 6e-123 yjbM 2.7.6.5 S RelA SpoT domain protein
ICIBICIF_01458 1.8e-113 yjbH Q Thioredoxin
ICIBICIF_01459 3.2e-205 coiA 3.6.4.12 S Competence protein
ICIBICIF_01460 1.2e-113 mecA NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
ICIBICIF_01461 1.7e-69 spxA 1.20.4.1 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
ICIBICIF_01462 6e-16 traP 1.14.99.57, 6.2.1.3 S enzyme involved in biosynthesis of extracellular polysaccharides
ICIBICIF_01482 2.1e-145 L 4.5 Transposon and IS
ICIBICIF_01483 3.3e-29 L Transposase
ICIBICIF_01484 3.1e-124 S Membrane
ICIBICIF_01485 3.2e-234 gltP U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
ICIBICIF_01486 0.0 pepF E oligoendopeptidase F
ICIBICIF_01487 2.1e-177 K helix_turn _helix lactose operon repressor
ICIBICIF_01488 1.1e-71 IQ Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
ICIBICIF_01489 2e-49 IQ Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
ICIBICIF_01490 1.9e-77 K AsnC family
ICIBICIF_01491 3e-81 uspA T universal stress protein
ICIBICIF_01492 2.1e-274 gnd 1.1.1.343, 1.1.1.44 H Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ICIBICIF_01493 2.6e-288 zwf 1.1.1.363, 1.1.1.49 G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ICIBICIF_01494 4.3e-206 yeaN P Transporter, major facilitator family protein
ICIBICIF_01495 1.5e-74 S 3-demethylubiquinone-9 3-methyltransferase
ICIBICIF_01496 2.4e-83 nrdI F Belongs to the NrdI family
ICIBICIF_01497 3.6e-252 yhdP S Transporter associated domain
ICIBICIF_01498 5.2e-90 GM epimerase
ICIBICIF_01499 5.8e-86 M1-874 K Domain of unknown function (DUF1836)
ICIBICIF_01500 8.3e-156 3.2.1.52 GH20 G Xylose isomerase domain protein TIM barrel
ICIBICIF_01501 1.6e-266 pipD E Dipeptidase
ICIBICIF_01502 3.2e-130
ICIBICIF_01503 7.1e-89 ybaK J Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ICIBICIF_01504 3.8e-98 gntR K UbiC transcription regulator-associated domain protein
ICIBICIF_01505 4.8e-148 ybjI 3.1.3.102, 3.1.3.104, 3.1.3.23 S haloacid dehalogenase-like hydrolase
ICIBICIF_01506 0.0 xfp 4.1.2.22, 4.1.2.9 G Phosphoketolase
ICIBICIF_01508 3.7e-282 yjeM E Amino Acid
ICIBICIF_01509 3.5e-188 K helix_turn _helix lactose operon repressor
ICIBICIF_01510 4.1e-259 G PTS system Galactitol-specific IIC component
ICIBICIF_01511 9.3e-175 rbsK 2.7.1.15 H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ICIBICIF_01512 6.9e-200 S Domain of unknown function (DUF4432)
ICIBICIF_01513 8.3e-114 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ICIBICIF_01514 2.4e-170 deoR K sugar-binding domain protein
ICIBICIF_01515 2.2e-165 rbsK 2.7.1.15 H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ICIBICIF_01516 2.1e-67 rbsD 5.4.99.62 G Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose
ICIBICIF_01517 2.7e-244 fucP G Major Facilitator Superfamily
ICIBICIF_01518 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ICIBICIF_01519 3.4e-26 L Transposase DDE domain group 1
ICIBICIF_01520 8.7e-40 L PFAM transposase, IS204 IS1001 IS1096 IS1165 family protein
ICIBICIF_01521 4e-147 L PFAM transposase, IS204 IS1001 IS1096 IS1165 family protein
ICIBICIF_01522 1e-122 K Crp-like helix-turn-helix domain
ICIBICIF_01523 3.4e-236 larA 5.1.2.1 S Domain of unknown function (DUF2088)
ICIBICIF_01524 7.9e-132 cpmA S AIR carboxylase
ICIBICIF_01525 7.3e-228 larC 4.99.1.12 S Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
ICIBICIF_01526 4.7e-146 larE S NAD synthase
ICIBICIF_01527 1.2e-132 glpF U Belongs to the MIP aquaporin (TC 1.A.8) family
ICIBICIF_01528 2.2e-174 hoxN U High-affinity nickel-transport protein
ICIBICIF_01529 2.2e-118 tkt 2.2.1.1 H Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ICIBICIF_01530 1.7e-125 rpiA 2.7.1.12, 5.3.1.6 G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ICIBICIF_01531 9.7e-135 tal 2.2.1.2 H Transaldolase/Fructose-6-phosphate aldolase
ICIBICIF_01532 0.0 tkt 2.2.1.1 H Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ICIBICIF_01533 5.5e-245 glpT G Major Facilitator Superfamily
ICIBICIF_01534 1.3e-129 qmcA O prohibitin homologues
ICIBICIF_01536 3.1e-75 uspA T universal stress protein
ICIBICIF_01537 2.1e-59
ICIBICIF_01538 6.6e-20
ICIBICIF_01539 4.5e-160
ICIBICIF_01540 7.1e-74 K Transcriptional regulator
ICIBICIF_01541 1.1e-186 D Alpha beta
ICIBICIF_01542 3.5e-73 O OsmC-like protein
ICIBICIF_01543 3.4e-191 lplA2 6.3.1.20 H Bacterial lipoate protein ligase C-terminus
ICIBICIF_01544 0.0 yjcE P Sodium proton antiporter
ICIBICIF_01545 6.8e-17 yvlA
ICIBICIF_01546 5.7e-115 P Cobalt transport protein
ICIBICIF_01547 9.2e-256 cbiO1 S ABC transporter, ATP-binding protein
ICIBICIF_01548 6.6e-100 S ABC-type cobalt transport system, permease component
ICIBICIF_01549 2.8e-179 iunH2 3.2.2.1 F nucleoside hydrolase
ICIBICIF_01550 4.4e-183 yumC 1.18.1.2, 1.19.1.1, 1.8.1.9 C Ferredoxin--NADP reductase
ICIBICIF_01551 8.2e-77 cadA 3.6.3.3, 3.6.3.5 P P-type ATPase
ICIBICIF_01552 3.8e-149 cadA 3.6.3.3, 3.6.3.5 P P-type ATPase
ICIBICIF_01553 8.6e-73 cadA 3.6.3.3, 3.6.3.5 P P-type ATPase
ICIBICIF_01554 2.8e-32 copZ P Heavy-metal-associated domain
ICIBICIF_01555 8.8e-101 dps P Belongs to the Dps family
ICIBICIF_01556 7.4e-107 rcfA 4.1.99.16, 4.2.3.22, 4.2.3.75 K helix_turn_helix, cAMP Regulatory protein
ICIBICIF_01557 2e-85
ICIBICIF_01558 0.0 ltaS 2.7.8.20 M Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
ICIBICIF_01559 2.5e-126 pgm3 G phosphoglycerate mutase family
ICIBICIF_01560 1.9e-150 qorB 1.6.5.2 GM NmrA-like family
ICIBICIF_01561 6e-228 pbuX F xanthine permease
ICIBICIF_01562 1e-170 corA P CorA-like Mg2+ transporter protein
ICIBICIF_01563 2.7e-168 rluA 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
ICIBICIF_01564 2.3e-142 terC P membrane
ICIBICIF_01565 1e-56 trxA1 O Belongs to the thioredoxin family
ICIBICIF_01566 2.6e-166 rbsK 2.7.1.15 H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ICIBICIF_01567 2.5e-161 glxR 1.1.1.31, 1.1.1.60 I Dehydrogenase
ICIBICIF_01568 8.8e-184 fruR3 K Transcriptional regulator, LacI family
ICIBICIF_01569 2.9e-170 scrK 2.7.1.2, 2.7.1.4 GK ROK family
ICIBICIF_01570 4.3e-234 mepA V MATE efflux family protein
ICIBICIF_01571 2.8e-224 amtB P ammonium transporter
ICIBICIF_01573 1.4e-133 XK27_08845 S ABC transporter, ATP-binding protein
ICIBICIF_01574 9.2e-103 XK27_08840 U Belongs to the binding-protein-dependent transport system permease family
ICIBICIF_01575 7.7e-18 XK27_08840 U Belongs to the binding-protein-dependent transport system permease family
ICIBICIF_01576 7e-181 ABC-SBP S ABC transporter
ICIBICIF_01577 3.4e-291 S ABC transporter, ATP-binding protein
ICIBICIF_01578 5.8e-205 nrnB S DHHA1 domain
ICIBICIF_01580 1.1e-109 M ErfK YbiS YcfS YnhG
ICIBICIF_01581 1.4e-83 nrdI F NrdI Flavodoxin like
ICIBICIF_01582 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ICIBICIF_01583 4.4e-169 nrdF 1.17.4.1 F Ribonucleotide reductase, small chain
ICIBICIF_01584 1.2e-182 1.17.4.1 F Ribonucleotide reductase, small chain
ICIBICIF_01585 1e-272 S Uncharacterized protein conserved in bacteria (DUF2325)
ICIBICIF_01586 2.3e-116 gph 3.1.3.18 S HAD hydrolase, family IA, variant
ICIBICIF_01587 3e-178 3.4.11.5 E Releases the N-terminal proline from various substrates
ICIBICIF_01588 0.0 pepX 3.4.14.11 E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline
ICIBICIF_01589 1.1e-205 yfnA E Amino Acid
ICIBICIF_01590 3.8e-72 apfA 2.7.7.72, 3.6.1.61 F Nudix hydrolase
ICIBICIF_01591 1.7e-105 gmk2 2.7.4.8 F Guanylate kinase
ICIBICIF_01592 4e-83 zur P Belongs to the Fur family
ICIBICIF_01594 2.2e-168
ICIBICIF_01595 8.1e-188 galM 5.1.3.3 G Catalyzes the interconversion of alpha and beta anomers of maltose
ICIBICIF_01596 1.9e-92 K Transcriptional regulator (TetR family)
ICIBICIF_01597 5.3e-207 V domain protein
ICIBICIF_01598 2e-80 K FR47-like protein
ICIBICIF_01599 1e-298 ybeC E amino acid
ICIBICIF_01600 1.2e-134 pnuC H nicotinamide mononucleotide transporter
ICIBICIF_01601 7.5e-208 menC 4.2.1.113 H Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)
ICIBICIF_01602 3.3e-231 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ICIBICIF_01603 5.8e-120 pgm7 5.4.2.11, 5.4.2.12 G phosphoglycerate mutase
ICIBICIF_01604 4.3e-118 dedA S SNARE associated Golgi protein
ICIBICIF_01605 0.0 helD 3.6.4.12 L DNA helicase
ICIBICIF_01606 2.5e-161 EG EamA-like transporter family
ICIBICIF_01607 0.0 ltaS 2.7.8.20 M Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
ICIBICIF_01608 1.5e-103 2.3.1.128 K acetyltransferase
ICIBICIF_01609 7e-175 coaA 2.7.1.33 F Pantothenic acid kinase
ICIBICIF_01610 5.2e-70 sptS 2.7.13.3 T Histidine kinase
ICIBICIF_01611 1.4e-79 K response regulator
ICIBICIF_01612 3.9e-113 2.7.6.5 T Region found in RelA / SpoT proteins
ICIBICIF_01613 5.7e-270 guaA 2.3.1.128, 6.3.5.2 F Catalyzes the synthesis of GMP from XMP
ICIBICIF_01614 0.0 norZ 1.7.2.5 P Cytochrome C and Quinol oxidase polypeptide I
ICIBICIF_01615 0.0 pacL 3.6.3.8, 3.6.3.9 P Cation transporter/ATPase, N-terminus
ICIBICIF_01617 1.5e-116
ICIBICIF_01618 1.2e-105 S Domain of unknown function (DUF4767)
ICIBICIF_01619 4.7e-54 K Helix-turn-helix domain
ICIBICIF_01620 2e-172 1.3.1.9 S Nitronate monooxygenase
ICIBICIF_01622 1.1e-73 rocF 3.5.3.1, 3.5.3.11 E Arginase family
ICIBICIF_01623 1.2e-49 ybjQ S Belongs to the UPF0145 family
ICIBICIF_01624 8.6e-224 dxs 2.2.1.7 HI 1-deoxy-D-xylulose-5-phosphate synthase
ICIBICIF_01625 6.1e-123 bm3R1 K Bacterial regulatory proteins, tetR family
ICIBICIF_01626 0.0 yhcA V ABC transporter, ATP-binding protein
ICIBICIF_01627 1.1e-51 S FMN_bind
ICIBICIF_01628 8.4e-168 M Membrane
ICIBICIF_01629 8.8e-24 XK27_06785 V ABC transporter
ICIBICIF_01630 2.2e-102 K Transcriptional regulator
ICIBICIF_01631 0.0 M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ICIBICIF_01632 4.7e-238 argG 6.3.4.5 E Belongs to the argininosuccinate synthase family. Type 1 subfamily
ICIBICIF_01633 6.2e-260 argH 4.3.2.1 E argininosuccinate lyase
ICIBICIF_01634 8.3e-43 lacA S transferase hexapeptide repeat
ICIBICIF_01635 2.6e-157 L Thioesterase-like superfamily
ICIBICIF_01637 7.3e-26 S NADPH-dependent FMN reductase
ICIBICIF_01638 3.2e-47 S NADPH-dependent FMN reductase
ICIBICIF_01639 5.2e-241 yfnA E amino acid
ICIBICIF_01640 2.5e-242 gabT 2.6.1.19 E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ICIBICIF_01642 7.5e-153 mleP3 S Membrane transport protein
ICIBICIF_01643 1.1e-52 trxA O Belongs to the thioredoxin family
ICIBICIF_01644 9.8e-255 gor 1.8.1.7 C pyridine nucleotide-disulfide oxidoreductase
ICIBICIF_01645 1.6e-208 EGP Major facilitator Superfamily
ICIBICIF_01646 2e-209 ycsG P Natural resistance-associated macrophage protein
ICIBICIF_01647 8.8e-136 ycsF S LamB/YcsF family
ICIBICIF_01648 2.2e-257 accC 6.3.4.14, 6.4.1.2 I Acetyl-CoA carboxylase biotin carboxylase subunit
ICIBICIF_01649 4.8e-54 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
ICIBICIF_01650 5e-190 kipA 6.3.4.6 E Allophanate hydrolase subunit 2
ICIBICIF_01651 1.6e-134 ybgJ 3.5.1.54 E Allophanate hydrolase subunit 1
ICIBICIF_01652 2.3e-72 K helix_turn_helix, mercury resistance
ICIBICIF_01653 1.9e-286 dinB 2.7.7.7 L impB/mucB/samB family C-terminal domain
ICIBICIF_01654 3.9e-66 wecD K Acetyltransferase (GNAT) family
ICIBICIF_01655 6.4e-105 3.2.1.17 NU mannosyl-glycoprotein
ICIBICIF_01656 7e-138 asnA 6.3.1.1 F aspartate--ammonia ligase
ICIBICIF_01657 3.1e-40 asnA 6.3.1.1 F aspartate--ammonia ligase
ICIBICIF_01658 1.1e-23 yjjG 3.1.3.102, 3.1.3.104, 3.1.3.5, 3.8.1.2 S HAD-hyrolase-like
ICIBICIF_01659 1.4e-214 2.1.1.14 E methionine synthase, vitamin-B12 independent
ICIBICIF_01660 3e-89 luxS 4.4.1.21 H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
ICIBICIF_01661 3.5e-38 S Cytochrome B5
ICIBICIF_01664 2.1e-15 S Domain of unknown function (DUF4811)
ICIBICIF_01665 4.2e-251 lmrB EGP Major facilitator Superfamily
ICIBICIF_01666 2.2e-96 K transcriptional regulator
ICIBICIF_01667 2.2e-72 nudG 3.6.1.55, 3.6.1.65 L NUDIX domain
ICIBICIF_01668 4e-270 L Helicase C-terminal domain protein
ICIBICIF_01669 1.6e-54 S MazG-like family
ICIBICIF_01670 1.4e-107 lssY 3.6.1.27 I Acid phosphatase homologues
ICIBICIF_01671 1.6e-146 pgl 3.1.1.31 G Lactonase, 7-bladed beta-propeller
ICIBICIF_01672 1.7e-96
ICIBICIF_01673 2.9e-224 dacA 3.4.16.4 M Belongs to the peptidase S11 family
ICIBICIF_01674 2e-169 ponA V Beta-lactamase enzyme family
ICIBICIF_01675 3.1e-265 yjeM E Amino Acid
ICIBICIF_01677 5.5e-112
ICIBICIF_01678 6.8e-164 S Polyphosphate nucleotide phosphotransferase, PPK2 family
ICIBICIF_01679 3.2e-164 K LysR substrate binding domain
ICIBICIF_01680 1.9e-261 S Uncharacterized protein conserved in bacteria (DUF2252)
ICIBICIF_01681 4.5e-301 scrB 3.2.1.26 GH32 G invertase
ICIBICIF_01682 2.3e-195 adhA 1.1.1.1 C Zinc-binding alcohol dehydrogenase family protein
ICIBICIF_01683 0.0 scrA 2.7.1.211, 5.3.1.1 G phosphotransferase system
ICIBICIF_01684 3.6e-108 ppiB 5.2.1.8 G PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ICIBICIF_01685 2.4e-79 mleR K LysR family
ICIBICIF_01686 1.2e-230 sfcA 1.1.1.38, 4.1.1.101 C Malic enzyme
ICIBICIF_01687 4.6e-183 XK27_09615 S reductase
ICIBICIF_01688 1.3e-30 XK27_09620 S NADPH-dependent FMN reductase
ICIBICIF_01689 1.5e-51 XK27_09620 S NADPH-dependent FMN reductase
ICIBICIF_01690 3e-222 fumC 4.2.1.2 C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
ICIBICIF_01691 1e-214 frdC 1.3.5.4 C FAD binding domain
ICIBICIF_01692 1.9e-224 yflS P Sodium:sulfate symporter transmembrane region
ICIBICIF_01693 6.6e-162 mleR K LysR family transcriptional regulator
ICIBICIF_01694 1.6e-252 yjjP S Putative threonine/serine exporter
ICIBICIF_01695 8e-120 ung2 3.2.2.27 L Uracil-DNA glycosylase
ICIBICIF_01696 2.4e-189 I Alpha beta
ICIBICIF_01697 2.3e-107 thiJ 2.7.11.1, 3.5.1.124 S DJ-1/PfpI family
ICIBICIF_01698 0.0 mprF 2.3.2.3 S Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ICIBICIF_01700 1.2e-168 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 J Responsible for synthesis of pseudouridine from uracil
ICIBICIF_01701 8.5e-150 araA 5.3.1.4 G Catalyzes the conversion of L-arabinose to L-ribulose
ICIBICIF_01702 9.9e-113 S Domain of unknown function (DUF4811)
ICIBICIF_01703 6.6e-268 lmrB EGP Major facilitator Superfamily
ICIBICIF_01704 1.9e-74 merR K MerR HTH family regulatory protein
ICIBICIF_01705 2e-58
ICIBICIF_01706 0.0 rnjA J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ICIBICIF_01707 6.3e-216 S CAAX protease self-immunity
ICIBICIF_01708 8.1e-33 elaA S GNAT family
ICIBICIF_01709 4.5e-85 usp1 T Belongs to the universal stress protein A family
ICIBICIF_01710 2.2e-109 S VIT family
ICIBICIF_01711 5.8e-23 S membrane
ICIBICIF_01712 6e-163 czcD P cation diffusion facilitator family transporter
ICIBICIF_01713 4.4e-123 sirR K iron dependent repressor
ICIBICIF_01714 3.3e-29 cspA K Cold shock protein
ICIBICIF_01715 6.3e-126 thrE S Putative threonine/serine exporter
ICIBICIF_01716 2.8e-82 S Threonine/Serine exporter, ThrE
ICIBICIF_01717 1.3e-114 lssY 3.6.1.27 I phosphatase
ICIBICIF_01718 1.3e-156 I alpha/beta hydrolase fold
ICIBICIF_01720 3.9e-268 lysP E amino acid
ICIBICIF_01721 7.9e-117 dak 2.7.1.74, 2.7.1.76 F deoxynucleoside kinase
ICIBICIF_01727 3.4e-11 IQ Enoyl-(Acyl carrier protein) reductase
ICIBICIF_01728 6.9e-18 IQ reductase
ICIBICIF_01729 1.6e-32 IQ reductase
ICIBICIF_01730 1.1e-147 uppP 3.6.1.27 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
ICIBICIF_01731 1.2e-16 S ABC-type cobalt transport system, permease component
ICIBICIF_01732 5.9e-39 S ABC-type cobalt transport system, permease component
ICIBICIF_01733 4.3e-70 thiW S Thiamine-precursor transporter protein (ThiW)
ICIBICIF_01734 9.7e-40 rmeB K transcriptional regulator, MerR family
ICIBICIF_01735 1.1e-29 maa 2.3.1.18, 2.3.1.79 S Maltose acetyltransferase
ICIBICIF_01736 6e-120 J 2'-5' RNA ligase superfamily
ICIBICIF_01737 1.3e-131 XK27_07210 6.1.1.6 S B3 4 domain
ICIBICIF_01738 9.7e-194 adhP 1.1.1.1 C alcohol dehydrogenase
ICIBICIF_01739 4.8e-79 ctsR K Belongs to the CtsR family
ICIBICIF_01740 0.0 clpC O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
ICIBICIF_01741 5.8e-106 K Bacterial regulatory proteins, tetR family
ICIBICIF_01742 0.0 rpoB 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ICIBICIF_01743 0.0 rpoC 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ICIBICIF_01744 5.6e-135 puuD S peptidase C26
ICIBICIF_01745 6.3e-213 ykiI
ICIBICIF_01746 2.1e-32 pilD 3.4.23.43 NOU aspartic-type endopeptidase activity
ICIBICIF_01747 3.2e-71 rpsL J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ICIBICIF_01748 2.1e-82 rpsG J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
ICIBICIF_01749 0.0 fusA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ICIBICIF_01750 2.6e-49 rpsJ J Involved in the binding of tRNA to the ribosomes
ICIBICIF_01751 8.7e-119 rplC J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ICIBICIF_01752 2.7e-106 rplD J Forms part of the polypeptide exit tunnel
ICIBICIF_01753 4.8e-45 rplW J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
ICIBICIF_01754 3.2e-150 rplB J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ICIBICIF_01755 8.4e-47 rpsS J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ICIBICIF_01756 2.2e-52 rplV J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ICIBICIF_01757 6.2e-117 rpsC J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ICIBICIF_01758 6e-76 rplP J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ICIBICIF_01759 1.1e-27 rpmC J Belongs to the universal ribosomal protein uL29 family
ICIBICIF_01760 6.5e-41 rpsQ J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ICIBICIF_01761 6.6e-60 rplN J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ICIBICIF_01762 5.2e-50 rplX J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ICIBICIF_01763 4.2e-95 rplE J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ICIBICIF_01764 5.2e-29 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ICIBICIF_01765 3e-66 rpsH J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ICIBICIF_01766 5.1e-93 rplF J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ICIBICIF_01767 3.9e-57 rplR J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ICIBICIF_01768 2.6e-86 rpsE J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ICIBICIF_01769 2.5e-23 rpmD J Ribosomal protein L30
ICIBICIF_01770 2.1e-65 rplO J Binds to the 23S rRNA
ICIBICIF_01771 1e-235 secY U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
ICIBICIF_01772 6.4e-122 adk 2.7.4.3 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
ICIBICIF_01773 2e-32 infA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ICIBICIF_01774 1.1e-13 rpmJ J Belongs to the bacterial ribosomal protein bL36 family
ICIBICIF_01775 9.5e-59 rpsM J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ICIBICIF_01776 1e-63 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ICIBICIF_01777 2e-169 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ICIBICIF_01778 2.8e-61 rplQ J Ribosomal protein L17
ICIBICIF_01779 6e-149 cbiO P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ICIBICIF_01780 5.8e-155 ecfA2 3.6.3.55 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ICIBICIF_01781 1.1e-139 ecfT U Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ICIBICIF_01782 2.2e-145 truA 5.4.99.12 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
ICIBICIF_01783 2.6e-79 rplM J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ICIBICIF_01784 1.5e-65 rpsI J Belongs to the universal ribosomal protein uS9 family
ICIBICIF_01785 1.3e-188 S interspecies interaction between organisms
ICIBICIF_01786 1.2e-138 IQ reductase
ICIBICIF_01787 5.8e-109 acmC 3.2.1.17, 3.2.1.96 NU mannosyl-glycoprotein
ICIBICIF_01788 3.2e-101 xpt 2.4.2.22, 2.4.2.7 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
ICIBICIF_01789 1.4e-220 purK2 6.3.4.18 F Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ICIBICIF_01790 0.0 pcrA 3.6.4.12 L ATP-dependent DNA helicase
ICIBICIF_01791 0.0 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ICIBICIF_01792 3.2e-166 camS S sex pheromone
ICIBICIF_01793 1e-48 gatC 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ICIBICIF_01794 3e-273 gatA 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
ICIBICIF_01795 5e-273 gatB 6.1.1.12, 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ICIBICIF_01796 9.6e-186 yegS 2.7.1.107 G Lipid kinase
ICIBICIF_01797 1.4e-264 rumA 2.1.1.190 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ICIBICIF_01798 7e-121 L Transposase and inactivated derivatives, IS30 family
ICIBICIF_01799 5.8e-76
ICIBICIF_01800 2.2e-35 K Cro/C1-type HTH DNA-binding domain
ICIBICIF_01801 1.2e-258 mod 2.1.1.72, 3.1.21.5 L DNA methylase
ICIBICIF_01802 0.0 res 2.1.1.72, 3.1.21.5 L Type III restriction enzyme, res subunit
ICIBICIF_01803 3.7e-214 K DNA binding
ICIBICIF_01804 0.0 L helicase activity
ICIBICIF_01805 2e-07
ICIBICIF_01806 0.0 cadA 3.6.3.3, 3.6.3.5 P E1-E2 ATPase
ICIBICIF_01807 5.6e-33 copZ P Heavy-metal-associated domain
ICIBICIF_01808 5.4e-46 D Di-iron-containing protein involved in the repair of iron-sulfur clusters
ICIBICIF_01809 4.1e-113 flp 4.1.99.16, 4.2.3.22, 4.2.3.75 K Transcriptional regulator, Crp Fnr family

eggNOG-mapper v2 (Database: eggNOG v5.0, Jul. 2018 release)