ORF_ID e_value Gene_name EC_number CAZy COGs Description
PFKLECOI_00001 1e-181 yaaC S YaaC-like Protein
PFKLECOI_00002 1.8e-273 guaB 1.1.1.205 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
PFKLECOI_00003 6.8e-248 dacA 3.4.16.4 M Belongs to the peptidase S11 family
PFKLECOI_00004 2.2e-157 pdxS 4.3.3.6 H Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
PFKLECOI_00005 8e-108 pdxT 4.3.3.6 H Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
PFKLECOI_00006 1.2e-206 serS 6.1.1.11 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PFKLECOI_00007 2.2e-122 dck 2.7.1.113, 2.7.1.74, 2.7.1.76 F Deoxycytidine kinase
PFKLECOI_00008 3.6e-114 dgk 2.7.1.113, 2.7.1.74, 2.7.1.76 F Deoxyguanosine kinase
PFKLECOI_00009 1.2e-212 yaaH M Glycoside Hydrolase Family
PFKLECOI_00010 5e-96 yaaI Q COG1335 Amidases related to nicotinamidase
PFKLECOI_00011 1.1e-83 tadA 3.5.4.1, 3.5.4.3, 3.5.4.33 FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
PFKLECOI_00012 0.0 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PFKLECOI_00013 5.3e-37 yaaK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PFKLECOI_00014 3.9e-110 recR L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PFKLECOI_00015 7.9e-32 yaaL S Protein of unknown function (DUF2508)
PFKLECOI_00016 3.7e-36 bofA S Sigma-K factor-processing regulatory protein BofA
PFKLECOI_00017 3.4e-39 S COG NOG14552 non supervised orthologous group
PFKLECOI_00018 8.5e-58 yabR J RNA binding protein (contains ribosomal protein S1 domain)
PFKLECOI_00019 1.1e-44 divIC D Septum formation initiator
PFKLECOI_00020 3.9e-108 yabQ S spore cortex biosynthesis protein
PFKLECOI_00021 1.5e-49 yabP S Sporulation protein YabP
PFKLECOI_00022 1.1e-37 yabO J COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
PFKLECOI_00023 7.8e-245 mazG 3.6.1.66, 3.6.1.9 S COG3956 Protein containing tetrapyrrole methyltransferase domain and MazG-like
PFKLECOI_00024 3.4e-278 yabM S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
PFKLECOI_00025 1.5e-92 spoVT K stage V sporulation protein
PFKLECOI_00026 0.0 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PFKLECOI_00027 2.4e-39 yabK S Peptide ABC transporter permease
PFKLECOI_00028 8e-105 pth 3.1.1.29 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
PFKLECOI_00029 8.7e-97 ctc J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PFKLECOI_00030 9.4e-175 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PFKLECOI_00031 1.9e-229 glmU 2.3.1.157, 2.7.7.23 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PFKLECOI_00032 4.6e-48 spoVG D Essential for sporulation. Interferes with or is a negative regulator of the pathway leading to asymmetric septation
PFKLECOI_00033 3.8e-63 yabJ 3.5.99.10 J translation initiation inhibitor, yjgF family
PFKLECOI_00034 2.6e-152 purR 2.4.2.22, 2.4.2.7 F pur operon repressor
PFKLECOI_00035 4.1e-161 ispE 2.1.1.182, 2.7.1.148 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PFKLECOI_00036 8.3e-27 sspF S DNA topological change
PFKLECOI_00037 7.8e-39 veg S protein conserved in bacteria
PFKLECOI_00038 1.6e-136 yabG S peptidase
PFKLECOI_00039 2e-155 ksgA 2.1.1.182 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
PFKLECOI_00040 3.5e-97 rnmV 3.1.26.8 J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
PFKLECOI_00041 2e-167 rpfB GH23 T protein conserved in bacteria
PFKLECOI_00042 1.2e-143 tatD L hydrolase, TatD
PFKLECOI_00043 0.0 metG 6.1.1.10, 6.1.1.20 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PFKLECOI_00044 8.8e-44 abrB K COG2002 Regulators of stationary sporulation gene expression
PFKLECOI_00045 4.3e-158 rsmI 2.1.1.198 H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
PFKLECOI_00046 1.5e-49 yazA L endonuclease containing a URI domain
PFKLECOI_00047 2.3e-136 yabB 2.1.1.223 S Conserved hypothetical protein 95
PFKLECOI_00048 4.8e-31 yabA L Involved in initiation control of chromosome replication
PFKLECOI_00049 6.1e-146 yaaT S stage 0 sporulation protein
PFKLECOI_00050 1.1e-181 holB 2.7.7.7 L DNA polymerase III
PFKLECOI_00051 1.5e-71 yaaR S protein conserved in bacteria
PFKLECOI_00052 2.2e-54 yaaQ S protein conserved in bacteria
PFKLECOI_00053 6.9e-113 tmk 2.7.4.9 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PFKLECOI_00054 1.6e-274 adiA 4.1.1.17, 4.1.1.18, 4.1.1.19 E Orn Lys Arg decarboxylase
PFKLECOI_00055 1.4e-201 yaaN P Belongs to the TelA family
PFKLECOI_00056 9.9e-101 xpaC S 5-bromo-4-chloroindolyl phosphate hydrolysis protein
PFKLECOI_00057 1.7e-30 csfB S Inhibitor of sigma-G Gin
PFKLECOI_00058 3.8e-287 lysS 6.1.1.6 J Belongs to the class-II aminoacyl-tRNA synthetase family
PFKLECOI_00059 4.1e-189 dus J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PFKLECOI_00060 4.1e-30 yazB K transcriptional
PFKLECOI_00061 1.8e-87 folK 1.13.11.81, 2.5.1.15, 2.7.6.3, 3.5.4.16, 4.1.2.25, 5.1.99.8 H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PFKLECOI_00062 5.9e-61 folB 1.13.11.81, 2.5.1.15, 2.7.6.3, 4.1.2.25, 5.1.99.8 H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PFKLECOI_00063 8.5e-159 folP 2.5.1.15, 2.7.6.3 H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PFKLECOI_00064 2.3e-167 pabC 2.6.1.42, 4.1.3.38 EH 4-amino-4-deoxychorismate lyase
PFKLECOI_00065 9.6e-106 pabA 2.6.1.85, 4.1.3.27 EH Anthranilate synthase
PFKLECOI_00066 6.3e-268 pabB 2.6.1.85 EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PFKLECOI_00067 2.6e-169 cysK 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
PFKLECOI_00068 3.4e-152 yacD 5.2.1.8 O peptidyl-prolyl isomerase
PFKLECOI_00069 2.9e-162 hslO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
PFKLECOI_00070 1.5e-146 coaX 2.7.1.33 F Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PFKLECOI_00071 0.0 ftsH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PFKLECOI_00072 7.9e-94 hpt 2.4.2.8, 6.3.4.19 F Belongs to the purine pyrimidine phosphoribosyltransferase family
PFKLECOI_00073 1.6e-271 tilS 2.4.2.8, 6.3.4.19 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
PFKLECOI_00074 2.2e-185 KLT serine threonine protein kinase
PFKLECOI_00075 1.5e-124 yabS S protein containing a von Willebrand factor type A (vWA) domain
PFKLECOI_00076 0.0 spoIIE 3.1.3.16, 3.1.3.3 KT stage II sporulation protein E
PFKLECOI_00077 2.9e-76 ctsR K Belongs to the CtsR family
PFKLECOI_00078 1.6e-47 mcsA 2.7.14.1 S protein with conserved CXXC pairs
PFKLECOI_00079 6.1e-202 mcsB 2.7.14.1, 2.7.3.2, 2.7.3.3 E Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity
PFKLECOI_00080 0.0 clpC O Belongs to the ClpA ClpB family
PFKLECOI_00081 6.2e-255 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
PFKLECOI_00082 1.3e-196 disA 2.7.7.85 L Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
PFKLECOI_00083 2.7e-197 yacL S COG4956 Integral membrane protein (PIN domain superfamily)
PFKLECOI_00084 1.5e-124 ispD 2.7.7.60, 4.6.1.12 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)
PFKLECOI_00085 3.1e-86 ispF 2.1.1.228, 2.7.7.60, 4.6.1.12 I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)
PFKLECOI_00086 2.5e-280 gltX 6.1.1.17, 6.1.1.24 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PFKLECOI_00087 7.2e-118 cysE 2.3.1.30 E Serine acetyltransferase
PFKLECOI_00088 1.1e-272 cysS 6.1.1.16, 6.3.1.13 J Belongs to the class-I aminoacyl-tRNA synthetase family
PFKLECOI_00089 3e-72 mrnC J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
PFKLECOI_00090 5.7e-135 trmH 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PFKLECOI_00091 1.2e-88 yacP S RNA-binding protein containing a PIN domain
PFKLECOI_00092 4.4e-115 sigH K Belongs to the sigma-70 factor family
PFKLECOI_00093 1e-21 secE U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
PFKLECOI_00094 5.2e-96 nusG K Participates in transcription elongation, termination and antitermination
PFKLECOI_00095 2.8e-70 rplK J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PFKLECOI_00096 1.1e-124 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
PFKLECOI_00097 5.1e-79 rplJ J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PFKLECOI_00098 1.3e-42 rplL J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
PFKLECOI_00099 8.2e-108 rsmC 2.1.1.172 J Methyltransferase
PFKLECOI_00100 0.0 rpoB 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PFKLECOI_00101 0.0 rpoC 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PFKLECOI_00102 8e-33 ybxF J Belongs to the eukaryotic ribosomal protein eL8 family
PFKLECOI_00103 8.5e-72 rpsL J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PFKLECOI_00104 6e-82 rpsG J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
PFKLECOI_00105 0.0 fusA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PFKLECOI_00106 2.5e-225 tuf J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PFKLECOI_00107 3.1e-178 ybaC 3.4.11.5 S Alpha/beta hydrolase family
PFKLECOI_00108 7.5e-49 rpsJ J Involved in the binding of tRNA to the ribosomes
PFKLECOI_00109 6.3e-111 rplC J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PFKLECOI_00110 3e-105 rplD J Forms part of the polypeptide exit tunnel
PFKLECOI_00111 1.2e-43 rplW J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
PFKLECOI_00112 1.5e-155 rplB J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PFKLECOI_00113 3.7e-47 rpsS J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PFKLECOI_00114 4.3e-53 rplV J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PFKLECOI_00115 6.2e-117 rpsC J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PFKLECOI_00116 1.3e-75 rplP J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PFKLECOI_00117 1.7e-25 rpmC J Belongs to the universal ribosomal protein uL29 family
PFKLECOI_00118 3.5e-39 rpsQ J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PFKLECOI_00119 3.9e-60 rplN J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PFKLECOI_00120 6.2e-51 rplX J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PFKLECOI_00121 4.6e-94 rplE J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PFKLECOI_00122 3.4e-28 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PFKLECOI_00123 3.9e-66 rpsH J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PFKLECOI_00124 1.3e-93 rplF J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PFKLECOI_00125 4e-57 rplR J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PFKLECOI_00126 3.1e-84 rpsE J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PFKLECOI_00127 1.9e-23 rpmD J Ribosomal protein L30
PFKLECOI_00128 1.8e-72 rplO J binds to the 23S rRNA
PFKLECOI_00129 4.2e-234 secY U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
PFKLECOI_00130 5.7e-123 adk 2.7.4.3 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
PFKLECOI_00131 3.7e-142 map 3.4.11.18 E Methionine aminopeptidase
PFKLECOI_00132 1.1e-33 infA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PFKLECOI_00133 4.2e-13 rpmJ J Belongs to the bacterial ribosomal protein bL36 family
PFKLECOI_00134 3.1e-57 rpsM J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PFKLECOI_00135 2.1e-64 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PFKLECOI_00136 3.1e-170 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PFKLECOI_00137 3.6e-58 rplQ J Ribosomal protein L17
PFKLECOI_00138 5.1e-156 cbiO P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
PFKLECOI_00139 5.4e-153 ecfA2 3.6.3.55 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
PFKLECOI_00140 1e-118 ecfT P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
PFKLECOI_00141 2.8e-142 truA 5.4.99.12 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
PFKLECOI_00142 6.4e-78 rplM J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PFKLECOI_00143 4.7e-64 rpsI J Belongs to the universal ribosomal protein uS9 family
PFKLECOI_00144 2.4e-144 ybaJ Q Methyltransferase domain
PFKLECOI_00145 9.7e-66 ybaK S Protein of unknown function (DUF2521)
PFKLECOI_00146 2.5e-132 cwlD 3.5.1.28 M n-acetylmuramoyl-L-alanine amidase
PFKLECOI_00147 1.4e-198 mrp D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP
PFKLECOI_00148 1.2e-84 gerD
PFKLECOI_00149 1.3e-102 kbaA 2.7.8.43 S Involved in the activation of the KinB signaling pathway of sporulation
PFKLECOI_00150 1.2e-140 pdaB 3.5.1.104 G Polysaccharide deacetylase
PFKLECOI_00151 1.3e-63 hxlR K transcriptional
PFKLECOI_00152 3.6e-106 hxlA 4.1.2.43 G 3-hexulose-6-phosphate synthase
PFKLECOI_00153 3e-96 hxlB 4.1.2.43, 5.3.1.27 G SIS domain
PFKLECOI_00154 4.3e-178 tlpC 2.7.13.3 NT chemotaxis protein
PFKLECOI_00155 7.8e-71 nucA M Deoxyribonuclease NucA/NucB
PFKLECOI_00156 1.2e-67 nin S Competence protein J (ComJ)
PFKLECOI_00157 1.2e-295 yckE 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
PFKLECOI_00158 7.8e-52 yckD S Protein of unknown function (DUF2680)
PFKLECOI_00159 4e-75 yckC S membrane
PFKLECOI_00160 1.7e-130 yckB ET COG0834 ABC-type amino acid transport signal transduction systems, periplasmic component domain
PFKLECOI_00161 5.4e-116 yecS P COG0765 ABC-type amino acid transport system, permease component
PFKLECOI_00162 1.6e-227 yciC S GTPases (G3E family)
PFKLECOI_00163 7.9e-108 yciB M ErfK YbiS YcfS YnhG
PFKLECOI_00164 4.6e-171 folE2 3.5.4.16 S Converts GTP to 7,8-dihydroneopterin triphosphate
PFKLECOI_00165 7.6e-222 nasA P COG2223 Nitrate nitrite transporter
PFKLECOI_00166 0.0 nirB 1.7.1.15 C Assimilatory nitrate reductase (electron transfer subunit)
PFKLECOI_00167 0.0 nasC C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
PFKLECOI_00168 0.0 nirB 1.7.1.15 C Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PFKLECOI_00169 4.6e-57 nirD 1.7.1.15 P Nitrite reductase
PFKLECOI_00170 2.7e-274 cobA 2.1.1.107, 4.2.1.75 H Belongs to the precorrin methyltransferase family
PFKLECOI_00171 2.4e-192 ycgT 1.18.1.2, 1.19.1.1 C Ferredoxin--NADP reductase
PFKLECOI_00172 1.9e-158 I alpha/beta hydrolase fold
PFKLECOI_00173 1.2e-139 ycgR S permeases
PFKLECOI_00174 1.7e-146 ycgQ S membrane
PFKLECOI_00175 1.6e-227 ycgP QT COG2508 Regulator of polyketide synthase expression
PFKLECOI_00176 9e-248 putP E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PFKLECOI_00177 7.3e-294 rocA 1.2.1.88, 1.5.5.2 C Belongs to the aldehyde dehydrogenase family. RocA subfamily
PFKLECOI_00178 5.1e-170 ycgM E Proline dehydrogenase
PFKLECOI_00179 2.9e-145 ycgL S Predicted nucleotidyltransferase
PFKLECOI_00180 4.7e-182 cah 3.1.1.41 Q Acetyl xylan esterase (AXE1)
PFKLECOI_00181 6.2e-174 oxyR3 K LysR substrate binding domain
PFKLECOI_00182 2.4e-144 yafE Q ubiE/COQ5 methyltransferase family
PFKLECOI_00183 1.5e-103 aroK 2.7.1.71, 4.2.3.4 F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PFKLECOI_00185 2.3e-107 tmrB S AAA domain
PFKLECOI_00186 4.5e-149 nadE 6.3.1.5 H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
PFKLECOI_00187 2.4e-112 ycgI S Domain of unknown function (DUF1989)
PFKLECOI_00188 8.1e-249 ycgH E COG1113 Gamma-aminobutyrate permease and related permeases
PFKLECOI_00189 9.2e-149 yqcI S YqcI/YcgG family
PFKLECOI_00190 6.8e-113 ycgF E Lysine exporter protein LysE YggA
PFKLECOI_00191 3.4e-77 emrR K helix_turn_helix multiple antibiotic resistance protein
PFKLECOI_00192 3.9e-263 mdr EGP Major facilitator Superfamily
PFKLECOI_00193 3.9e-290 lctP C L-lactate permease
PFKLECOI_00194 3.3e-183 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
PFKLECOI_00195 0.0 amyE 3.2.1.1 GH13 G alpha-amylase
PFKLECOI_00196 3.5e-80 ycgB
PFKLECOI_00197 4.7e-255 ycgA S Membrane
PFKLECOI_00198 1.4e-217 amhX S amidohydrolase
PFKLECOI_00199 1.5e-163 opuAC E glycine betaine
PFKLECOI_00200 8.5e-127 opuAB P glycine betaine
PFKLECOI_00201 5.1e-229 proV 3.6.3.32 E glycine betaine
PFKLECOI_00202 6.1e-45 K helix_turn_helix, Arsenical Resistance Operon Repressor
PFKLECOI_00203 5.7e-206 yceJ EGP Uncharacterised MFS-type transporter YbfB
PFKLECOI_00204 1.5e-217 naiP P Uncharacterised MFS-type transporter YbfB
PFKLECOI_00205 2e-192 yceH P Belongs to the TelA family
PFKLECOI_00206 0.0 yceG S Putative component of 'biosynthetic module'
PFKLECOI_00207 7e-136 terC P Protein of unknown function (DUF475)
PFKLECOI_00208 4.6e-108 yceE T proteins involved in stress response, homologs of TerZ and
PFKLECOI_00209 2.8e-105 yceD T proteins involved in stress response, homologs of TerZ and
PFKLECOI_00210 1.9e-109 yceC 3.5.4.33 T proteins involved in stress response, homologs of TerZ and
PFKLECOI_00211 4.2e-186 yceB C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PFKLECOI_00212 1.7e-135 adcB P COG1108 ABC-type Mn2 Zn2 transport systems, permease components
PFKLECOI_00213 9.4e-132 adcC P 'COG1121 ABC-type Mn Zn transport systems, ATPase component'
PFKLECOI_00214 4.3e-167 adcA P Belongs to the bacterial solute-binding protein 9 family
PFKLECOI_00215 0.0 ycdG 3.2.1.10 GH13 G COG0366 Glycosidases
PFKLECOI_00216 1e-139 IQ Enoyl-(Acyl carrier protein) reductase
PFKLECOI_00217 1.2e-173 S response regulator aspartate phosphatase
PFKLECOI_00218 1.1e-94 cwlK M D-alanyl-D-alanine carboxypeptidase
PFKLECOI_00219 6.1e-261 ycdC K Belongs to the sigma-70 factor family. ECF subfamily
PFKLECOI_00220 9.4e-272 ycdB K Belongs to the sigma-70 factor family. ECF subfamily
PFKLECOI_00221 1.9e-176 ycdA S Domain of unknown function (DUF5105)
PFKLECOI_00222 6e-174 yccK C Aldo keto reductase
PFKLECOI_00223 3.5e-200 natB CP ABC-2 family transporter protein
PFKLECOI_00224 1.2e-132 natA 3.6.3.7 CP ATPases associated with a variety of cellular activities
PFKLECOI_00225 1.2e-126 lytR_2 T LytTr DNA-binding domain
PFKLECOI_00226 9.5e-159 2.7.13.3 T GHKL domain
PFKLECOI_00227 9.5e-200 yccF K DNA-templated transcriptional preinitiation complex assembly
PFKLECOI_00228 7.1e-57 S RDD family
PFKLECOI_00229 5.6e-115 lip 3.1.1.3 S acetyltransferases and hydrolases with the alpha beta hydrolase fold
PFKLECOI_00230 2.6e-200 ansB 3.5.1.1 EJ COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D
PFKLECOI_00231 6.3e-102 yxaF K Transcriptional regulator
PFKLECOI_00232 3e-225 lmrB EGP the major facilitator superfamily
PFKLECOI_00233 2.7e-205 ycbU E Selenocysteine lyase
PFKLECOI_00234 1.3e-119 pcp 3.4.19.3 O Removes 5-oxoproline from various penultimate amino acid residues except L-proline
PFKLECOI_00235 1.7e-123 tatC U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PFKLECOI_00236 5e-28 tatA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
PFKLECOI_00237 0.0 phoD 3.1.3.1 P COG3540 Phosphodiesterase alkaline phosphatase D
PFKLECOI_00238 6.6e-136 ycbR T vWA found in TerF C terminus
PFKLECOI_00239 1.3e-78 sleB 3.5.1.28 M Cell wall
PFKLECOI_00240 8.2e-53 ycbP S Protein of unknown function (DUF2512)
PFKLECOI_00241 2.1e-115 S ABC-2 family transporter protein
PFKLECOI_00242 4.8e-168 ycbN V ABC transporter, ATP-binding protein
PFKLECOI_00243 3.8e-168 T PhoQ Sensor
PFKLECOI_00244 2.9e-125 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
PFKLECOI_00245 1.9e-167 eamA1 EG spore germination
PFKLECOI_00246 4.4e-24 rtpA K Tryptophan RNA-binding attenuator protein inhibitory protein
PFKLECOI_00247 3.1e-175 ycbJ S Macrolide 2'-phosphotransferase
PFKLECOI_00248 5.9e-296 garD 4.2.1.42, 4.2.1.7 G Altronate
PFKLECOI_00249 1.9e-124 ycbG K FCD
PFKLECOI_00250 1.9e-269 gudD 4.2.1.40 M Belongs to the mandelate racemase muconate lactonizing enzyme family
PFKLECOI_00251 1.7e-254 gudP G COG0477 Permeases of the major facilitator superfamily
PFKLECOI_00252 7.6e-272 ycbD C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
PFKLECOI_00253 2.7e-174 kdgD 4.2.1.41 EM 5-dehydro-4-deoxyglucarate dehydratase activity
PFKLECOI_00254 2.6e-169 glnL T Regulator
PFKLECOI_00255 2.1e-228 phoQ 2.7.13.3 T Histidine kinase
PFKLECOI_00256 3.8e-187 glsA 3.5.1.2 E Belongs to the glutaminase family
PFKLECOI_00257 1.3e-255 agcS E Sodium alanine symporter
PFKLECOI_00258 3.9e-181 mmuM 1.5.1.20, 2.1.1.10 H homocysteine
PFKLECOI_00259 7.5e-261 mmuP E amino acid
PFKLECOI_00260 4.6e-202 ilvE 2.6.1.42 E Branched-chain amino acid aminotransferase
PFKLECOI_00262 4.9e-128 K UTRA
PFKLECOI_00263 8e-137 nagB 3.1.1.31, 3.5.99.6 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
PFKLECOI_00264 0.0 ptsG 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
PFKLECOI_00265 4.9e-216 gltP C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
PFKLECOI_00266 1.5e-191 yceA S Belongs to the UPF0176 family
PFKLECOI_00267 3.2e-46 ybfN
PFKLECOI_00268 8.1e-148 psd 4.1.1.65 I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)
PFKLECOI_00269 2.7e-85 ybfM S SNARE associated Golgi protein
PFKLECOI_00270 9.2e-95 pssA 2.7.8.8 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PFKLECOI_00271 8.8e-167 S Alpha/beta hydrolase family
PFKLECOI_00273 1.5e-177 mpr 3.4.21.19 M Belongs to the peptidase S1B family
PFKLECOI_00274 6.4e-210 purT 2.1.2.2 F Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
PFKLECOI_00275 2.3e-145 msmR K AraC-like ligand binding domain
PFKLECOI_00276 7.6e-158 ybfH EG EamA-like transporter family
PFKLECOI_00277 0.0 ybfG M Domain of unknown function (DUF1906)
PFKLECOI_00279 2.1e-222 ybfB G COG0477 Permeases of the major facilitator superfamily
PFKLECOI_00280 5.1e-170 ybfA 3.4.15.5 K FR47-like protein
PFKLECOI_00281 2.1e-33 S Protein of unknown function (DUF2651)
PFKLECOI_00282 7.3e-258 glpT G -transporter
PFKLECOI_00283 4.8e-165 glpQ 3.1.4.46 C glycerophosphoryl diester phosphodiesterase
PFKLECOI_00284 1.8e-290 ybeC E amino acid
PFKLECOI_00285 4.9e-41 ybyB
PFKLECOI_00286 7.8e-246 cypC 1.11.2.4, 1.14.14.1 Q Cytochrome P450
PFKLECOI_00287 7.2e-152 ybxI 3.5.2.6 V beta-lactamase
PFKLECOI_00288 4.9e-30 ybxH S Family of unknown function (DUF5370)
PFKLECOI_00289 3.7e-38 csgA S Sigma-G-dependent sporulation-specific SASP protein
PFKLECOI_00290 1.5e-258 yifK E COG1113 Gamma-aminobutyrate permease and related permeases
PFKLECOI_00291 9.8e-214 ybdO S Domain of unknown function (DUF4885)
PFKLECOI_00292 1.7e-151 ybdN
PFKLECOI_00293 8.8e-139 KLT Protein tyrosine kinase
PFKLECOI_00294 7.2e-170 T His Kinase A (phospho-acceptor) domain
PFKLECOI_00295 1.5e-123 T Transcriptional regulatory protein, C terminal
PFKLECOI_00296 2.6e-180 S hydrolases or acyltransferases (alpha beta hydrolase superfamily)
PFKLECOI_00297 1.2e-55
PFKLECOI_00298 7.7e-203 ybcL EGP Major facilitator Superfamily
PFKLECOI_00299 5.1e-50 ybzH K Helix-turn-helix domain
PFKLECOI_00300 4.7e-61 ybcI S Uncharacterized conserved protein (DUF2294)
PFKLECOI_00301 3.9e-47
PFKLECOI_00303 5.5e-92 can 4.2.1.1 P carbonic anhydrase
PFKLECOI_00304 0.0 ybcC S Belongs to the UPF0753 family
PFKLECOI_00305 1e-271 ndhF 1.6.5.3 CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit
PFKLECOI_00306 9.6e-100 ogt 2.1.1.63, 3.2.2.21 L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PFKLECOI_00307 4.9e-119 adaA 3.2.2.21 K Transcriptional regulator
PFKLECOI_00308 1.5e-174 alkA 3.2.2.21 L COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
PFKLECOI_00309 0.0 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
PFKLECOI_00310 9.3e-253 glmM 5.4.2.10 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PFKLECOI_00311 5.7e-224 ybbR S protein conserved in bacteria
PFKLECOI_00312 2.7e-146 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
PFKLECOI_00313 1.8e-102 rsiW K Is the anti-sigma factor for SigW. The presence of RsiW leads to the inactivation of SigW, and its proteolytic destruction to sigma-W activation
PFKLECOI_00314 2.5e-98 sigW K Belongs to the sigma-70 factor family. ECF subfamily
PFKLECOI_00318 3.7e-76 ybbK 2.4.2.1, 6.3.2.4 S Protein of unknown function (DUF523)
PFKLECOI_00319 1.9e-86 ybbJ J acetyltransferase
PFKLECOI_00320 3e-162 murQ 4.2.1.126 G Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
PFKLECOI_00321 2.1e-149 ybbH K transcriptional
PFKLECOI_00322 1.7e-233 ybbF 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
PFKLECOI_00323 1.1e-250 yfeW 3.4.16.4 V Belongs to the UPF0214 family
PFKLECOI_00324 0.0 ybbD 3.2.1.52 G Belongs to the glycosyl hydrolase 3 family
PFKLECOI_00325 1.7e-237 ybbC 3.2.1.52 S protein conserved in bacteria
PFKLECOI_00326 4.2e-305 ybbB K COG2207 AraC-type DNA-binding domain-containing proteins
PFKLECOI_00327 4e-165 feuA P Iron-uptake system-binding protein
PFKLECOI_00328 1.1e-176 feuB P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PFKLECOI_00329 3e-179 feuC P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PFKLECOI_00330 5.4e-141 ybbA S Putative esterase
PFKLECOI_00331 1.3e-160 ybaS 1.1.1.58 S Na -dependent transporter
PFKLECOI_00333 1.5e-245 ybaR P COG0659 Sulfate permease and related transporters (MFS superfamily)
PFKLECOI_00334 1.4e-220 srfAA Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
PFKLECOI_00335 4e-89 srfAB Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
PFKLECOI_00336 5.3e-245 srfAB Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
PFKLECOI_00337 0.0 srfAC Q COG1020 Non-ribosomal peptide synthetase modules and related proteins
PFKLECOI_00338 5.7e-140 srfAD Q thioesterase
PFKLECOI_00339 7.5e-225 EGP Major Facilitator Superfamily
PFKLECOI_00340 4.2e-90 S YcxB-like protein
PFKLECOI_00341 1.3e-160 ycxC EG EamA-like transporter family
PFKLECOI_00342 2.1e-249 ycxD K GntR family transcriptional regulator
PFKLECOI_00343 1.9e-113 acpT 2.7.8.7 H Belongs to the P-Pant transferase superfamily
PFKLECOI_00344 9.7e-115 yczE S membrane
PFKLECOI_00345 2.8e-134 tcyC 3.6.3.21 E COG1126 ABC-type polar amino acid transport system, ATPase component
PFKLECOI_00346 6.2e-123 tcyB P COG0765 ABC-type amino acid transport system, permease component
PFKLECOI_00347 2e-138 tcyA ET Belongs to the bacterial solute-binding protein 3 family
PFKLECOI_00348 1.9e-161 bsdA K LysR substrate binding domain
PFKLECOI_00349 1.1e-107 ubiX 2.5.1.129 H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN
PFKLECOI_00350 1.2e-282 yclC 4.1.1.61 H Decarboxylase involved in the decarboxylation and detoxification of phenolic derivatives under both aerobic and anaerobic conditions. It is able to catalyze the reversible decarboxylation of 4-hydroxybenzoate
PFKLECOI_00351 4e-39 bsdD 4.1.1.61 S response to toxic substance
PFKLECOI_00352 5e-81 yclD
PFKLECOI_00353 3.4e-160 yclE 3.4.11.5 S Alpha beta hydrolase
PFKLECOI_00354 1.8e-265 dtpT E amino acid peptide transporter
PFKLECOI_00355 2.5e-298 yclG M Pectate lyase superfamily protein
PFKLECOI_00357 1.5e-281 gerKA EG Spore germination protein
PFKLECOI_00358 5.2e-226 gerKC S spore germination
PFKLECOI_00359 5.6e-195 gerKB F Spore germination protein
PFKLECOI_00360 1.9e-121 yclH P ABC transporter
PFKLECOI_00361 1.1e-203 yclI V ABC transporter (permease) YclI
PFKLECOI_00362 2.3e-127 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
PFKLECOI_00363 1.7e-260 yclK 2.7.13.3 T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain
PFKLECOI_00364 5.8e-78 S aspartate phosphatase
PFKLECOI_00368 7.5e-242 lysC 2.7.2.4 E Belongs to the aspartokinase family
PFKLECOI_00369 3.5e-161 yclN P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PFKLECOI_00370 2.6e-164 fatC P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PFKLECOI_00371 1.8e-136 yclP 3.6.3.34 P ABC transporter, ATP-binding protein
PFKLECOI_00372 2.7e-166 yclQ P COG4607 ABC-type enterochelin transport system, periplasmic component
PFKLECOI_00373 7e-251 ycnB EGP Major facilitator Superfamily
PFKLECOI_00374 1.6e-152 ycnC K Transcriptional regulator
PFKLECOI_00375 2.2e-134 nfrA2 1.5.1.38, 1.5.1.39 C Oxidoreductase
PFKLECOI_00376 1.6e-45 ycnE S Monooxygenase
PFKLECOI_00377 2.2e-51 yczG K helix_turn_helix, Arsenical Resistance Operon Repressor
PFKLECOI_00378 3.9e-273 gabR K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
PFKLECOI_00379 4.8e-246 gabT 2.6.1.19, 2.6.1.22 E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PFKLECOI_00380 3.8e-265 gabD 1.2.1.16, 1.2.1.20, 1.2.1.79 C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
PFKLECOI_00381 6.1e-149 glcU U Glucose uptake
PFKLECOI_00382 9.9e-146 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
PFKLECOI_00383 1.4e-99 ycnI S protein conserved in bacteria
PFKLECOI_00384 9.3e-308 ycnJ P protein, homolog of Cu resistance protein CopC
PFKLECOI_00385 2.8e-105 ycnK K COG1349 Transcriptional regulators of sugar metabolism
PFKLECOI_00386 3.4e-53
PFKLECOI_00387 2.1e-239 mtlA 2.7.1.197 G COG2213 Phosphotransferase system, mannitol-specific IIBC component
PFKLECOI_00388 3.4e-71 mtlF 2.7.1.197 G COG4668 Mannitol fructose-specific phosphotransferase system, IIA domain
PFKLECOI_00389 1.8e-209 mtlD 1.1.1.17 G COG0246 Mannitol-1-phosphate altronate dehydrogenases
PFKLECOI_00390 3.8e-201 ycsA 1.1.1.83, 1.1.1.93, 4.1.1.73 CE Tartrate dehydrogenase
PFKLECOI_00391 2.5e-98 sipT 3.4.21.89 U Belongs to the peptidase S26 family
PFKLECOI_00392 3e-110 M1-673 3.1.1.45 Q COG0412 Dienelactone hydrolase and related enzymes
PFKLECOI_00393 5.4e-68 fabZ 3.5.1.108, 4.2.1.59 I FabA-like domain
PFKLECOI_00395 8e-137 ycsE 3.1.3.104 S Sucrose-6F-phosphate phosphohydrolase
PFKLECOI_00396 1.2e-140 ycsF S Belongs to the UPF0271 (lamB) family
PFKLECOI_00397 6.5e-213 ycsG P COG1914 Mn2 and Fe2 transporters of the NRAMP family
PFKLECOI_00398 3.7e-148 ycsI S Belongs to the D-glutamate cyclase family
PFKLECOI_00399 1e-133 kipI 3.5.1.54 E Allophanate hydrolase subunit 1
PFKLECOI_00400 5.1e-187 kipA 6.3.4.6 E Allophanate hydrolase subunit 2
PFKLECOI_00401 1.7e-131 kipR K Transcriptional regulator
PFKLECOI_00402 1.3e-119 ycsK E anatomical structure formation involved in morphogenesis
PFKLECOI_00404 1.4e-49 yczJ S biosynthesis
PFKLECOI_00405 0.0 pbpC 3.4.16.4 M Penicillin-binding Protein
PFKLECOI_00406 3.4e-174 ydhF S Oxidoreductase
PFKLECOI_00407 0.0 mtlR K transcriptional regulator, MtlR
PFKLECOI_00408 1.8e-292 ydaB IQ acyl-CoA ligase
PFKLECOI_00409 9e-99 ydaC Q Methyltransferase domain
PFKLECOI_00410 1.4e-161 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
PFKLECOI_00411 1.2e-96 MA20_27600 5.3.1.15 S Cupin 2, conserved barrel domain protein
PFKLECOI_00412 7.3e-103 rimL 1.1.1.25 J COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
PFKLECOI_00413 6.8e-77 ydaG 1.4.3.5 S general stress protein
PFKLECOI_00414 3.5e-138 amj U Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane
PFKLECOI_00415 3.6e-45 ydzA EGP Major facilitator Superfamily
PFKLECOI_00416 2.5e-74 lrpC K Transcriptional regulator
PFKLECOI_00417 0.0 topB 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PFKLECOI_00418 2.1e-207 ydaJ M Belongs to the glycosyl hydrolase 8 (cellulase D) family
PFKLECOI_00419 1.1e-150 ydaK T Diguanylate cyclase, GGDEF domain
PFKLECOI_00420 0.0 ydaL S Uncharacterized protein conserved in bacteria (DUF2334)
PFKLECOI_00421 1.1e-231 ydaM M Glycosyl transferase family group 2
PFKLECOI_00422 0.0 ydaN S Bacterial cellulose synthase subunit
PFKLECOI_00423 0.0 ydaO E amino acid
PFKLECOI_00424 2.1e-76 mutT 3.6.1.13, 3.6.1.55 L Belongs to the Nudix hydrolase family
PFKLECOI_00425 0.0 poxB 1.2.3.3, 1.2.5.1 EH Belongs to the TPP enzyme family
PFKLECOI_00426 2.1e-39
PFKLECOI_00427 1.3e-224 mntH P H( )-stimulated, divalent metal cation uptake system
PFKLECOI_00429 3.3e-77 ydaT S Uncharacterized protein conserved in bacteria (DUF2188)
PFKLECOI_00430 1.3e-145 ydbA 3.6.3.4, 3.6.3.54 P EcsC protein family
PFKLECOI_00432 8.9e-59 ydbB G Cupin domain
PFKLECOI_00433 1.1e-62 ydbC S Domain of unknown function (DUF4937
PFKLECOI_00434 6.7e-153 ydbD P Catalase
PFKLECOI_00435 1.9e-197 dctB G COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component
PFKLECOI_00436 6.2e-296 dctS 2.7.13.3 T Signal transduction histidine kinase regulating citrate malate metabolism
PFKLECOI_00437 8.1e-120 dctR T COG4565 Response regulator of citrate malate metabolism
PFKLECOI_00438 1.4e-226 dctA U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
PFKLECOI_00439 9.7e-181 ydbI S AI-2E family transporter
PFKLECOI_00440 1.8e-170 ydbJ V ABC transporter, ATP-binding protein
PFKLECOI_00441 9.4e-125 ydbK S COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
PFKLECOI_00442 2.7e-52 ydbL
PFKLECOI_00443 1.5e-219 ydbM 1.3.8.1 I acyl-CoA dehydrogenase
PFKLECOI_00444 1.1e-18 S Fur-regulated basic protein B
PFKLECOI_00445 2.2e-07 S Fur-regulated basic protein A
PFKLECOI_00446 2.5e-150 yeaB P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PFKLECOI_00447 2.3e-56 ydbP 2.7.1.180, 5.3.4.1 CO Thioredoxin
PFKLECOI_00448 3.9e-201 ddl 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
PFKLECOI_00449 1.4e-254 murF 6.3.2.10 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
PFKLECOI_00450 9e-249 cshA 3.6.4.13 JKL DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
PFKLECOI_00451 2.1e-82 ydbS S Bacterial PH domain
PFKLECOI_00452 3e-260 ydbT S Membrane
PFKLECOI_00453 1.5e-106 ydcA 3.4.21.105 S membrane protein (homolog of Drosophila rhomboid)
PFKLECOI_00454 2.1e-58 acpS 2.7.6.3, 2.7.8.7, 5.1.1.1 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
PFKLECOI_00455 8.5e-183 ydcC M COG2834 Outer membrane lipoprotein-sorting protein
PFKLECOI_00456 7.4e-222 alr 5.1.1.1, 5.1.1.5 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PFKLECOI_00457 4.8e-42 ndoAI K transcriptional regulators containing the CopG Arc MetJ DNA-binding domain and a metal-binding domain
PFKLECOI_00458 2.5e-56 ndoA L Toxic component of a toxin-antitoxin (TA) module
PFKLECOI_00459 1.3e-143 rsbR T Positive regulator of sigma-B
PFKLECOI_00460 5.2e-57 rsbS T antagonist
PFKLECOI_00461 1.3e-69 rsbT 2.7.11.1 T COG2172 Anti-sigma regulatory factor (Ser Thr protein kinase)
PFKLECOI_00462 7.1e-189 rsbU 3.1.3.3 KT phosphatase
PFKLECOI_00463 7e-53 rsbV T Belongs to the anti-sigma-factor antagonist family
PFKLECOI_00464 2.4e-86 rsbW 2.7.11.1 F Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B)
PFKLECOI_00465 3.4e-138 sigB K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PFKLECOI_00466 4.8e-108 rsbX 3.1.3.16, 3.1.3.3 KT Sigma factor PP2C-like phosphatases
PFKLECOI_00467 0.0 yhgF K COG2183 Transcriptional accessory protein
PFKLECOI_00468 8.9e-83 ydcK S Belongs to the SprT family
PFKLECOI_00477 4.6e-157 ydhU P Catalase
PFKLECOI_00478 1.1e-211 gmuG 3.2.1.78 GH26 G Belongs to the glycosyl hydrolase 26 family
PFKLECOI_00479 1.3e-187 manA 5.3.1.8 G mannose-6-phosphate isomerase
PFKLECOI_00480 3e-170 gmuE 2.7.1.2, 2.7.1.4 GK COG1940 Transcriptional regulator sugar kinase
PFKLECOI_00481 1.1e-132 ydhQ K UTRA
PFKLECOI_00482 3.6e-284 ydhP 3.2.1.21, 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
PFKLECOI_00483 1.5e-234 celB G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
PFKLECOI_00484 8.7e-51 ydhN3 2.7.1.196, 2.7.1.205 G phosphotransferase system
PFKLECOI_00485 1.9e-47 ydhM 2.7.1.196, 2.7.1.205 G phosphotransferase system
PFKLECOI_00486 4.6e-200 pbuE EGP Major facilitator Superfamily
PFKLECOI_00487 2.5e-98 ydhK M Protein of unknown function (DUF1541)
PFKLECOI_00488 6.2e-182 ydhJ S Metal dependent phosphohydrolases with conserved 'HD' motif.
PFKLECOI_00489 3.3e-80 K Acetyltransferase (GNAT) domain
PFKLECOI_00491 2.8e-66 frataxin S Domain of unknown function (DU1801)
PFKLECOI_00492 9e-259 phoB 3.1.3.1 P Belongs to the alkaline phosphatase family
PFKLECOI_00493 1.1e-122
PFKLECOI_00494 7e-228 ydhE CG COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase
PFKLECOI_00495 1.4e-242 ydhD M Glycosyl hydrolase
PFKLECOI_00496 9.8e-102 ydhC K FCD
PFKLECOI_00497 1.2e-121 ydhB S membrane transporter protein
PFKLECOI_00498 7.4e-209 tcaB EGP Major facilitator Superfamily
PFKLECOI_00499 2.4e-69 ydgJ K Winged helix DNA-binding domain
PFKLECOI_00500 2.3e-113 drgA C nitroreductase
PFKLECOI_00501 0.0 ydgH S drug exporters of the RND superfamily
PFKLECOI_00502 4.7e-80 K helix_turn_helix multiple antibiotic resistance protein
PFKLECOI_00503 1.7e-90 dinB S DinB family
PFKLECOI_00504 4e-251 cycA E COG1113 Gamma-aminobutyrate permease and related permeases
PFKLECOI_00505 3.1e-303 expZ S ABC transporter
PFKLECOI_00506 2.1e-44 yycN 2.3.1.128 K Acetyltransferase
PFKLECOI_00507 1.6e-52 S DoxX-like family
PFKLECOI_00508 1.4e-99 K Bacterial regulatory proteins, tetR family
PFKLECOI_00509 1.3e-41 ydgB S Spore germination protein gerPA/gerPF
PFKLECOI_00510 1.4e-37 ydgA S Spore germination protein gerPA/gerPF
PFKLECOI_00511 1.7e-75 cotP O Belongs to the small heat shock protein (HSP20) family
PFKLECOI_00512 5.2e-122 ydfS S Protein of unknown function (DUF421)
PFKLECOI_00513 4.4e-118 ydfR S Protein of unknown function (DUF421)
PFKLECOI_00515 4.8e-29
PFKLECOI_00516 7.1e-15 ydgA S Spore germination protein gerPA/gerPF
PFKLECOI_00517 8.5e-54 traF CO Thioredoxin
PFKLECOI_00518 7.5e-62 mhqP S DoxX
PFKLECOI_00519 2e-185 ydfO E COG0346 Lactoylglutathione lyase and related lyases
PFKLECOI_00520 2.6e-109 ydfN C nitroreductase
PFKLECOI_00521 2.9e-154 fieF P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PFKLECOI_00522 9.2e-147 K Bacterial transcription activator, effector binding domain
PFKLECOI_00523 1.9e-116 S Protein of unknown function (DUF554)
PFKLECOI_00524 1.4e-175 S Alpha/beta hydrolase family
PFKLECOI_00525 0.0 ydfJ S drug exporters of the RND superfamily
PFKLECOI_00526 9.3e-110 ydfI K Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
PFKLECOI_00527 1.8e-175 ydfH 2.7.13.3 T Histidine kinase
PFKLECOI_00529 1e-78 ydfG S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PFKLECOI_00530 2.7e-123 ydfF K helix_turn_helix, Arsenical Resistance Operon Repressor
PFKLECOI_00531 2.1e-114 ydfE S Flavin reductase like domain
PFKLECOI_00532 3e-273 ydfD K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
PFKLECOI_00533 9.8e-153 ydfC EG EamA-like transporter family
PFKLECOI_00534 3.4e-146 ydfB J GNAT acetyltransferase
PFKLECOI_00535 3.7e-230 arsB P Involved in arsenical resistance. Thought to form the channel of an arsenite pump
PFKLECOI_00536 2.8e-57 arsR K transcriptional
PFKLECOI_00537 2.1e-103 ydeS K Transcriptional regulator
PFKLECOI_00538 8.1e-184 ydeR EGP Major facilitator Superfamily
PFKLECOI_00539 3.6e-108 ydeQ S NADPH-quinone reductase (modulator of drug activity B)
PFKLECOI_00540 1.1e-68 ydeP K Transcriptional regulator
PFKLECOI_00541 6e-152 yqfU S Uncharacterized protein conserved in bacteria (DUF2179)
PFKLECOI_00542 5.7e-55 K HxlR-like helix-turn-helix
PFKLECOI_00543 8.9e-104 ydeN S Serine hydrolase
PFKLECOI_00544 4.2e-74 maoC I N-terminal half of MaoC dehydratase
PFKLECOI_00545 2.1e-271 ydeL K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
PFKLECOI_00546 4.1e-153 ydeK EG -transporter
PFKLECOI_00547 8.8e-85 K Transcriptional regulator C-terminal region
PFKLECOI_00548 1.8e-14 ptsH G PTS HPr component phosphorylation site
PFKLECOI_00549 2.4e-70 S SNARE associated Golgi protein
PFKLECOI_00550 3.8e-140 T PhoQ Sensor
PFKLECOI_00551 2.5e-113 T Transcriptional regulator
PFKLECOI_00552 5.8e-77 ksgA1 I Ribosomal RNA adenine dimethylase
PFKLECOI_00553 3.6e-109
PFKLECOI_00554 6.4e-105 ydeI S Bacteriocin-protection, YdeI or OmpD-Associated
PFKLECOI_00555 5.2e-44 ydeH
PFKLECOI_00556 4.6e-217 ydeG EGP Major facilitator superfamily
PFKLECOI_00557 2.8e-260 K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
PFKLECOI_00558 4.8e-165 ydeE K AraC family transcriptional regulator
PFKLECOI_00559 3.4e-172 yicL EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
PFKLECOI_00560 3.3e-166 rhaS5 K AraC-like ligand binding domain
PFKLECOI_00561 2.8e-141 ydzE EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
PFKLECOI_00562 6.8e-78 carD K Transcription factor
PFKLECOI_00563 8.7e-30 cspL K Cold shock
PFKLECOI_00564 8.3e-193 des 1.14.19.23, 1.14.19.45 I fatty acid desaturase
PFKLECOI_00565 9.6e-40
PFKLECOI_00566 3.4e-33 K Helix-turn-helix XRE-family like proteins
PFKLECOI_00567 4.5e-15 yhcS 3.4.22.70 M COG3764 Sortase (surface protein transpeptidase)
PFKLECOI_00568 5e-47 ydeH
PFKLECOI_00569 9e-208 msbA2 3.6.3.44 V ABC transporter
PFKLECOI_00570 9.8e-211 KLT Protein kinase domain
PFKLECOI_00572 7.8e-08
PFKLECOI_00574 4.8e-182 thiL 2.7.4.16 H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PFKLECOI_00575 5.9e-85 ydiB 2.7.1.221, 5.1.1.1 S ATPase or kinase
PFKLECOI_00576 2.5e-124 yeaZ 2.3.1.234 O COG1214 Inactive homolog of metal-dependent proteases
PFKLECOI_00577 2.8e-84 rimI 2.3.1.128 K This enzyme acetylates the N-terminal alanine of ribosomal protein S18
PFKLECOI_00578 5.2e-187 tsaD 2.3.1.234 O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PFKLECOI_00579 0.0 ydiF S ABC transporter
PFKLECOI_00580 5.5e-89 moaC 4.6.1.17 H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)
PFKLECOI_00581 8.8e-116 rex K Modulates transcription in response to changes in cellular NADH NAD( ) redox state
PFKLECOI_00582 7.5e-22 tatA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
PFKLECOI_00583 4.1e-125 tatC U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PFKLECOI_00584 2.9e-27 ydiK S Domain of unknown function (DUF4305)
PFKLECOI_00585 1.3e-128 ydiL S CAAX protease self-immunity
PFKLECOI_00586 1.3e-42 groS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PFKLECOI_00587 3.7e-280 groL O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
PFKLECOI_00588 8.9e-152 ydjC S Abhydrolase domain containing 18
PFKLECOI_00589 0.0 K NB-ARC domain
PFKLECOI_00590 8e-199 gutB 1.1.1.14 E Dehydrogenase
PFKLECOI_00591 1.7e-249 gutA G MFS/sugar transport protein
PFKLECOI_00592 1.5e-172 ydjE 2.7.1.4 G pfkB family carbohydrate kinase
PFKLECOI_00593 5.6e-113 pspA KT Phage shock protein A
PFKLECOI_00594 9.8e-178 ydjG 3.6.4.12 L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PFKLECOI_00595 1.2e-135 ydjH S COG1512 Beta-propeller domains of methanol dehydrogenase type
PFKLECOI_00596 1.4e-149 ydjI S virion core protein (lumpy skin disease virus)
PFKLECOI_00597 8e-196 S Ion transport 2 domain protein
PFKLECOI_00598 1.1e-256 iolT EGP Major facilitator Superfamily
PFKLECOI_00599 5.2e-195 bdhA 1.1.1.303, 1.1.1.4 E Dehydrogenase
PFKLECOI_00600 4.5e-64 ydjM M Lytic transglycolase
PFKLECOI_00601 2.9e-153 ydjN U Involved in the tonB-independent uptake of proteins
PFKLECOI_00603 1.2e-34 ydjO S Cold-inducible protein YdjO
PFKLECOI_00604 3.1e-158 ydjP I Alpha/beta hydrolase family
PFKLECOI_00605 1.3e-174 yeaA S Protein of unknown function (DUF4003)
PFKLECOI_00606 0.0 cotA 1.10.3.4, 1.16.3.3 Q multicopper oxidases
PFKLECOI_00607 2.2e-252 gabP E COG1113 Gamma-aminobutyrate permease and related permeases
PFKLECOI_00608 3.8e-154 yeaB P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PFKLECOI_00609 1.7e-176 yeaC S COG0714 MoxR-like ATPases
PFKLECOI_00610 4e-223 yeaD S conserved protein (some members contain a von Willebrand factor type A (vWA) domain)
PFKLECOI_00611 0.0 yebA E COG1305 Transglutaminase-like enzymes
PFKLECOI_00612 8.3e-306 guaA 2.3.1.128, 6.3.5.2 F Catalyzes the synthesis of GMP from XMP
PFKLECOI_00613 1.2e-83 K Belongs to the sigma-70 factor family. ECF subfamily
PFKLECOI_00614 7.5e-248 S Domain of unknown function (DUF4179)
PFKLECOI_00615 1.5e-210 pbuG S permease
PFKLECOI_00616 2.4e-115 yebC M Membrane
PFKLECOI_00618 4e-93 yebE S UPF0316 protein
PFKLECOI_00619 6.8e-27 yebG S NETI protein
PFKLECOI_00620 2.5e-83 purE 5.4.99.18 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
PFKLECOI_00621 4.7e-213 purK 6.3.4.18 F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
PFKLECOI_00622 9.6e-247 purB 4.3.2.2 F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PFKLECOI_00623 2.8e-131 purC 4.1.1.21, 4.3.2.2, 6.3.2.6 F Belongs to the SAICAR synthetase family
PFKLECOI_00624 2.9e-38 purS 6.3.2.6, 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PFKLECOI_00625 5.1e-130 purQ 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PFKLECOI_00626 0.0 purL 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PFKLECOI_00627 1.3e-268 purF 2.4.2.14 F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
PFKLECOI_00628 3.8e-177 purM 6.3.3.1, 6.3.4.13 F Phosphoribosylformylglycinamidine cyclo-ligase
PFKLECOI_00629 3.7e-105 purN 2.1.2.2 F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PFKLECOI_00630 3e-287 purH 2.1.2.3, 3.5.4.10 F Bifunctional purine biosynthesis protein PurH
PFKLECOI_00631 2e-233 purD 6.3.4.13 F Belongs to the GARS family
PFKLECOI_00632 1e-72 K helix_turn_helix ASNC type
PFKLECOI_00633 2.8e-230 yjeH E Amino acid permease
PFKLECOI_00634 2.7e-27 S Protein of unknown function (DUF2892)
PFKLECOI_00635 0.0 yerA 3.5.4.2 F adenine deaminase
PFKLECOI_00636 4.9e-190 yerB S Protein of unknown function (DUF3048) C-terminal domain
PFKLECOI_00637 4.8e-51 yerC S protein conserved in bacteria
PFKLECOI_00638 6.7e-303 yerD 1.4.7.1 E Belongs to the glutamate synthase family
PFKLECOI_00639 4.9e-125 pcrB I 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
PFKLECOI_00640 0.0 pcrA 3.6.4.12 L ATP-dependent DNA helicase
PFKLECOI_00641 0.0 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PFKLECOI_00642 4.1e-220 camS S COG4851 Protein involved in sex pheromone biosynthesis
PFKLECOI_00643 3.2e-197 yerI S homoserine kinase type II (protein kinase fold)
PFKLECOI_00644 6.1e-123 sapB S MgtC SapB transporter
PFKLECOI_00645 2e-264 putP E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PFKLECOI_00646 2.1e-45 gatC 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PFKLECOI_00647 1.2e-274 gatA 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
PFKLECOI_00648 6.8e-270 gatB 6.1.1.12, 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PFKLECOI_00649 1.5e-147 yerO K Transcriptional regulator
PFKLECOI_00650 0.0 swrC V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PFKLECOI_00651 3e-170 yegS 2.7.1.107 I COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
PFKLECOI_00652 2.4e-256 rumA 2.1.1.190 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PFKLECOI_00653 5e-20
PFKLECOI_00654 0.0 K SIR2-like domain
PFKLECOI_00656 1.2e-99 S response regulator aspartate phosphatase
PFKLECOI_00658 1.3e-42 S Immunity protein 22
PFKLECOI_00659 8.1e-186 yobL S Bacterial EndoU nuclease
PFKLECOI_00660 6.9e-176 3.4.24.40 CO amine dehydrogenase activity
PFKLECOI_00661 1.8e-39
PFKLECOI_00662 4.3e-211 S Tetratricopeptide repeat
PFKLECOI_00664 2.7e-126 yeeN K transcriptional regulatory protein
PFKLECOI_00666 1.2e-103 dhaR3 K Transcriptional regulator
PFKLECOI_00667 9.7e-82 yesE S SnoaL-like domain
PFKLECOI_00668 1.3e-151 yesF GM NAD(P)H-binding
PFKLECOI_00669 5.3e-45 cotJA S Spore coat associated protein JA (CotJA)
PFKLECOI_00670 1.5e-45 cotJB S CotJB protein
PFKLECOI_00671 5.2e-104 cotJC P Spore Coat
PFKLECOI_00672 1.8e-101 yesJ K Acetyltransferase (GNAT) family
PFKLECOI_00674 9.2e-102 yesL S Protein of unknown function, DUF624
PFKLECOI_00675 0.0 yesM 2.7.13.3 T Histidine kinase
PFKLECOI_00676 2.8e-202 yesN K helix_turn_helix, arabinose operon control protein
PFKLECOI_00677 1.1e-247 yesO G Bacterial extracellular solute-binding protein
PFKLECOI_00678 2.8e-171 yesP G Binding-protein-dependent transport system inner membrane component
PFKLECOI_00679 1e-162 yesQ P Binding-protein-dependent transport system inner membrane component
PFKLECOI_00680 7.8e-199 3.2.1.172 GH105 S Glycosyl Hydrolase Family 88
PFKLECOI_00681 0.0 yesS K Transcriptional regulator
PFKLECOI_00682 3.3e-129 E GDSL-like Lipase/Acylhydrolase
PFKLECOI_00683 1.6e-125 yesU S Domain of unknown function (DUF1961)
PFKLECOI_00684 9.7e-112 yesV S Protein of unknown function, DUF624
PFKLECOI_00685 0.0 yesX 4.2.2.23, 4.2.2.24 PL11 E cell wall organization
PFKLECOI_00686 0.0 yesX 4.2.2.23, 4.2.2.24 PL11 E cell wall organization
PFKLECOI_00687 1.5e-123 yesY E GDSL-like Lipase/Acylhydrolase
PFKLECOI_00688 0.0 yesZ 3.2.1.23 G beta-galactosidase activity
PFKLECOI_00689 0.0 yetA
PFKLECOI_00690 6.2e-290 lplA G Bacterial extracellular solute-binding protein
PFKLECOI_00691 3.2e-175 lplB G COG4209 ABC-type polysaccharide transport system, permease component
PFKLECOI_00692 6.5e-162 lplC G Binding-protein-dependent transport system inner membrane component
PFKLECOI_00693 1.3e-254 lplD 3.2.1.122, 3.2.1.22, 3.2.1.86 GH4,GT4 G Family 4 glycosyl hydrolase
PFKLECOI_00694 4e-122 yetF S membrane
PFKLECOI_00695 3.7e-54 isdI 1.14.99.48, 1.14.99.57 S Antibiotic biosynthesis monooxygenase
PFKLECOI_00696 2e-64 yetH E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PFKLECOI_00697 2.2e-34
PFKLECOI_00698 1.9e-145 T COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
PFKLECOI_00699 8.9e-20 yezD S Uncharacterized small protein (DUF2292)
PFKLECOI_00700 1.7e-103 yetJ S Belongs to the BI1 family
PFKLECOI_00701 2.4e-30 yetM CH FAD binding domain
PFKLECOI_00702 6.8e-75
PFKLECOI_00703 4.4e-21
PFKLECOI_00704 4.6e-108 S Uncharacterised protein conserved in bacteria (DUF2326)
PFKLECOI_00705 6.7e-167 ygxA S Nucleotidyltransferase-like
PFKLECOI_00706 9.5e-56 ygzB S UPF0295 protein
PFKLECOI_00707 4e-80 perR P Belongs to the Fur family
PFKLECOI_00708 2.8e-87 bcp 1.11.1.15 O Peroxiredoxin
PFKLECOI_00709 1.4e-245 gsaB 5.4.3.8 H Glutamate-1-semialdehyde aminotransferase
PFKLECOI_00710 8.7e-180 ygaE S Membrane
PFKLECOI_00711 1.8e-301 ygaD V ABC transporter
PFKLECOI_00712 1.3e-104 ygaC J Belongs to the UPF0374 family
PFKLECOI_00713 1.5e-37 ygaB S YgaB-like protein
PFKLECOI_00714 2.4e-08 sspE S Small, acid-soluble spore protein, gamma-type
PFKLECOI_00715 2.9e-134 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
PFKLECOI_00716 6.9e-36 yfhS
PFKLECOI_00717 9.5e-210 mutY L A G-specific
PFKLECOI_00718 1.2e-185 yfhP S membrane-bound metal-dependent
PFKLECOI_00719 0.0 yfhO S Bacterial membrane protein YfhO
PFKLECOI_00720 2.7e-185 csbB GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
PFKLECOI_00721 1.3e-170 yfhM S Alpha beta hydrolase
PFKLECOI_00722 1e-47 yfhL S SdpI/YhfL protein family
PFKLECOI_00723 1.3e-90 batE T Bacterial SH3 domain homologues
PFKLECOI_00724 1.3e-44 yfhJ S WVELL protein
PFKLECOI_00725 6.2e-20 sspK S reproduction
PFKLECOI_00726 2.1e-208 yfhI EGP Major facilitator Superfamily
PFKLECOI_00728 9.7e-52 yfhH S Protein of unknown function (DUF1811)
PFKLECOI_00729 1.1e-141 recX 2.4.1.337 GT4 S Modulates RecA activity
PFKLECOI_00730 3.5e-171 yfhF S nucleoside-diphosphate sugar epimerase
PFKLECOI_00732 2.1e-25 yfhD S YfhD-like protein
PFKLECOI_00733 3.9e-107 yfhC C nitroreductase
PFKLECOI_00734 1.8e-167 yfhB 5.3.3.17 S PhzF family
PFKLECOI_00735 1.2e-170 yfhA P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PFKLECOI_00736 3.1e-176 yfiZ P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PFKLECOI_00737 6.2e-182 yfiY P ABC transporter substrate-binding protein
PFKLECOI_00738 0.0 mprF 2.3.2.3 S Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
PFKLECOI_00739 1.4e-78 yfiV K transcriptional
PFKLECOI_00740 4e-284 yfiU EGP Major facilitator Superfamily
PFKLECOI_00741 4.7e-99 yfiT S Belongs to the metal hydrolase YfiT family
PFKLECOI_00742 5.9e-197 yfiQ G COG3936 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
PFKLECOI_00743 4.4e-80 estA 3.1.1.3 S acetyltransferases and hydrolases with the alpha beta hydrolase fold
PFKLECOI_00744 8.3e-99 padR K transcriptional
PFKLECOI_00745 4e-204 V COG0842 ABC-type multidrug transport system, permease component
PFKLECOI_00746 4e-207 V ABC-2 family transporter protein
PFKLECOI_00747 1.2e-166 V ABC transporter, ATP-binding protein
PFKLECOI_00748 5.4e-113 KT LuxR family transcriptional regulator
PFKLECOI_00749 1.8e-212 yxjM T Histidine kinase
PFKLECOI_00751 2.8e-162 yfiE 1.13.11.2 S glyoxalase
PFKLECOI_00752 6.4e-64 mhqP S DoxX
PFKLECOI_00753 0.0 yfiC V COG1132 ABC-type multidrug transport system, ATPase and permease components
PFKLECOI_00754 8.4e-307 yfiB3 V ABC transporter
PFKLECOI_00755 4.7e-296 glvC 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
PFKLECOI_00756 7.1e-141 glvR K Helix-turn-helix domain, rpiR family
PFKLECOI_00757 4.9e-262 aglB 3.2.1.122, 3.2.1.22, 3.2.1.86 GH4,GT4 G COG1486 Alpha-galactosidases 6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases
PFKLECOI_00758 3.7e-43 yfjA S Belongs to the WXG100 family
PFKLECOI_00759 2.7e-190 yfjB
PFKLECOI_00760 4.1e-144 yfjC
PFKLECOI_00761 3.4e-100 yfjD S Family of unknown function (DUF5381)
PFKLECOI_00762 2.5e-79 S Family of unknown function (DUF5381)
PFKLECOI_00763 4e-56 yfjF S UPF0060 membrane protein
PFKLECOI_00764 1.2e-25 sspH S Belongs to the SspH family
PFKLECOI_00765 0.0 acoR KQ COG3284 Transcriptional activator of acetoin glycerol metabolism
PFKLECOI_00766 2.3e-254 acoL 1.8.1.4 C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
PFKLECOI_00767 3.5e-195 acoC 2.3.1.12, 2.3.1.61 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
PFKLECOI_00768 8.5e-190 acoB C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
PFKLECOI_00769 2.6e-191 acoA C COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
PFKLECOI_00770 8.7e-29 yfjL
PFKLECOI_00771 3.4e-82 yfjM S Psort location Cytoplasmic, score
PFKLECOI_00772 1.1e-186 yfjN J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PFKLECOI_00773 3.9e-44 S YfzA-like protein
PFKLECOI_00774 4e-267 rumA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PFKLECOI_00775 1e-167 yfjP 3.2.2.21 L COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
PFKLECOI_00776 8.5e-184 corA P Mediates influx of magnesium ions
PFKLECOI_00777 3.6e-149 yfjR 1.1.1.31 I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PFKLECOI_00778 1.7e-153 pdaA G deacetylase
PFKLECOI_00779 1.1e-26 yfjT
PFKLECOI_00780 1.7e-220 yfkA S YfkB-like domain
PFKLECOI_00781 1.7e-148 yfkC M Mechanosensitive ion channel
PFKLECOI_00782 1.2e-146 yfkD S YfkD-like protein
PFKLECOI_00783 1.8e-182 cax P COG0387 Ca2 H antiporter
PFKLECOI_00784 2e-219 ycaD EGP COG0477 Permeases of the major facilitator superfamily
PFKLECOI_00785 9.7e-144 yihY S Belongs to the UPF0761 family
PFKLECOI_00786 2.4e-50 yfkI S gas vesicle protein
PFKLECOI_00787 1e-81 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PFKLECOI_00788 2.1e-29 yfkK S Belongs to the UPF0435 family
PFKLECOI_00789 2.6e-206 ydiM EGP Major facilitator Superfamily
PFKLECOI_00790 3.6e-88 yfkM 1.11.1.6, 3.5.1.124 S protease
PFKLECOI_00791 0.0 cpdB 3.1.3.5, 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
PFKLECOI_00792 1.2e-123 yfkO C nitroreductase
PFKLECOI_00793 1.8e-133 treR K transcriptional
PFKLECOI_00794 0.0 treC 3.2.1.93 GH13 G COG0366 Glycosidases
PFKLECOI_00795 8.5e-257 treP 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
PFKLECOI_00796 4.5e-26 yfkQ EG Spore germination protein
PFKLECOI_00797 6.3e-252 agcS_1 E Sodium alanine symporter
PFKLECOI_00798 5.1e-66 yhdN S Domain of unknown function (DUF1992)
PFKLECOI_00799 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
PFKLECOI_00800 1.5e-250 nagE 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G COG1263 Phosphotransferase system IIC components, glucose maltose N-acetylglucosamine-specific
PFKLECOI_00801 1.1e-138 map 3.4.11.18 E Methionine aminopeptidase
PFKLECOI_00802 9.1e-50 yflH S Protein of unknown function (DUF3243)
PFKLECOI_00803 4.1e-19 yflI
PFKLECOI_00804 8.9e-18 yflJ S Protein of unknown function (DUF2639)
PFKLECOI_00805 6.4e-122 yflK S protein conserved in bacteria
PFKLECOI_00806 1.1e-43 acyP 3.6.1.7 C Belongs to the acylphosphatase family
PFKLECOI_00807 8.7e-217 nos 1.14.14.47 C Belongs to the NOS family. Bacterial NOS oxygenase subfamily
PFKLECOI_00808 6.7e-150 yflN S COG0491 Zn-dependent hydrolases, including glyoxylases
PFKLECOI_00809 2.5e-226 citM C Citrate transporter
PFKLECOI_00810 2.2e-179 yflP S Tripartite tricarboxylate transporter family receptor
PFKLECOI_00811 2.2e-117 citT T response regulator
PFKLECOI_00812 1.7e-288 citS 2.7.13.3 T Signal transduction histidine kinase regulating citrate malate metabolism
PFKLECOI_00813 3.2e-235 yflS P Sodium:sulfate symporter transmembrane region
PFKLECOI_00814 1.4e-239 pel 4.2.2.10, 4.2.2.2 G Pectate lyase
PFKLECOI_00815 7.6e-58 yflT S Heat induced stress protein YflT
PFKLECOI_00816 5e-24 S Protein of unknown function (DUF3212)
PFKLECOI_00817 1.7e-155 fecB P COG4594 ABC-type Fe3 -citrate transport system, periplasmic component
PFKLECOI_00818 4.7e-169 viuD P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PFKLECOI_00819 1.2e-169 fecD P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PFKLECOI_00820 1.1e-149 yfmF 3.6.3.34 P ATPases associated with a variety of cellular activities
PFKLECOI_00821 3.3e-296 1.14.99.50 S Sulfatase-modifying factor enzyme 1
PFKLECOI_00822 2.2e-213 G Major Facilitator Superfamily
PFKLECOI_00823 2.5e-189 yfmJ S N-terminal domain of oxidoreductase
PFKLECOI_00824 3.1e-80 yfmK 2.3.1.128 K acetyltransferase
PFKLECOI_00825 2.2e-199 yfmL 3.6.4.13 L COG0513 Superfamily II DNA and RNA helicases
PFKLECOI_00826 7.1e-297 yfmM S COG0488 ATPase components of ABC transporters with duplicated ATPase domains
PFKLECOI_00827 1.5e-209 yfmO EGP Major facilitator Superfamily
PFKLECOI_00828 1.4e-69 yfmP K transcriptional
PFKLECOI_00829 1.2e-74 yfmQ S Uncharacterised protein from bacillus cereus group
PFKLECOI_00830 0.0 yfmR S COG0488 ATPase components of ABC transporters with duplicated ATPase domains
PFKLECOI_00831 1.1e-113 yfmS NT chemotaxis protein
PFKLECOI_00832 2.8e-279 yfmT 1.2.1.3, 1.2.1.67 C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
PFKLECOI_00833 2.4e-240 yfnA E amino acid
PFKLECOI_00834 8.1e-131 yjjG 3.1.3.102, 3.1.3.104, 3.1.3.5, 3.8.1.2 S Haloacid dehalogenase-like hydrolase
PFKLECOI_00835 4.6e-206 fsr P COG0477 Permeases of the major facilitator superfamily
PFKLECOI_00836 1e-189 yfnD M Nucleotide-diphospho-sugar transferase
PFKLECOI_00837 4.2e-225 yfnE 2.4.1.338 GT2 S Glycosyltransferase like family 2
PFKLECOI_00838 1.1e-180 yfnF M Nucleotide-diphospho-sugar transferase
PFKLECOI_00839 7.1e-172 yfnG 4.2.1.45 M dehydratase
PFKLECOI_00840 3e-147 rfbF 2.7.7.33 JM Nucleotidyl transferase
PFKLECOI_00841 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
PFKLECOI_00842 0.0 cypD 1.14.14.1, 1.6.2.4 C Belongs to the cytochrome P450 family
PFKLECOI_00843 7.9e-67 yetN S Protein of unknown function (DUF3900)
PFKLECOI_00846 2e-08
PFKLECOI_00850 2.7e-143 spo0M S COG4326 Sporulation control protein
PFKLECOI_00851 3e-27
PFKLECOI_00852 2.9e-133 pepE 3.4.11.2, 3.4.13.21 E Belongs to the peptidase S51 family
PFKLECOI_00853 0.0 thiC 4.1.99.17 H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PFKLECOI_00854 6.5e-262 ygaK C Berberine and berberine like
PFKLECOI_00856 7.9e-290 katA 1.11.1.6 P serves to protect cells from the toxic effects of hydrogen peroxide
PFKLECOI_00857 3.7e-137 ssuB P COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component
PFKLECOI_00858 2.1e-169 ssuA M Sulfonate ABC transporter
PFKLECOI_00859 1.5e-147 ssuC P COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component
PFKLECOI_00860 3.1e-217 ssuD 1.14.14.5 C Catalyzes the desulfonation of aliphatic sulfonates
PFKLECOI_00862 6e-42 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PFKLECOI_00863 6.9e-78 ygaO
PFKLECOI_00864 4.4e-29 K Transcriptional regulator
PFKLECOI_00866 8.7e-113 yhzB S B3/4 domain
PFKLECOI_00867 3e-223 queG 1.17.99.6 C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PFKLECOI_00868 1.7e-176 yhbB S Putative amidase domain
PFKLECOI_00869 8.2e-87 trmL 2.1.1.207 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
PFKLECOI_00870 1.2e-109 yhbD K Protein of unknown function (DUF4004)
PFKLECOI_00871 1.6e-65 yhbE M COG1664 Integral membrane protein CcmA involved in cell shape determination
PFKLECOI_00872 8.2e-75 yhbF M COG1664 Integral membrane protein CcmA involved in cell shape determination
PFKLECOI_00873 0.0 prkA T Ser protein kinase
PFKLECOI_00874 2.5e-225 yhbH S Belongs to the UPF0229 family
PFKLECOI_00875 2.2e-76 yhbI K DNA-binding transcription factor activity
PFKLECOI_00876 4e-97 yhbJ V COG1566 Multidrug resistance efflux pump
PFKLECOI_00877 3.1e-271 yhcA EGP Major facilitator Superfamily
PFKLECOI_00878 1e-98 yhcB 1.6.5.2 S Belongs to the WrbA family
PFKLECOI_00879 2.8e-37 yhcC
PFKLECOI_00880 3.5e-55
PFKLECOI_00881 1.9e-59 yhcF K Transcriptional regulator
PFKLECOI_00882 4e-122 yhcG V ABC transporter, ATP-binding protein
PFKLECOI_00883 7.7e-166 yhcH V ABC transporter, ATP-binding protein
PFKLECOI_00884 2.5e-164 yhcI S COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
PFKLECOI_00885 1e-30 cspB K Cold-shock protein
PFKLECOI_00886 1.1e-150 metQ M Belongs to the nlpA lipoprotein family
PFKLECOI_00887 1.3e-196 yhcK 2.7.7.65 T COG2199 FOG GGDEF domain
PFKLECOI_00888 6.3e-220 ydjN U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
PFKLECOI_00889 1.3e-38 yhcM
PFKLECOI_00890 2.1e-68 yhcN S Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
PFKLECOI_00891 7.3e-167 yhcP
PFKLECOI_00892 1.5e-99 yhcQ M Spore coat protein
PFKLECOI_00893 0.0 yhcR 3.1.3.5, 3.1.31.1 F Belongs to the 5'-nucleotidase family
PFKLECOI_00894 2.1e-103 yhcS 3.4.22.70 M COG3764 Sortase (surface protein transpeptidase)
PFKLECOI_00895 8.7e-170 rluA 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
PFKLECOI_00896 9.3e-68 yhcU S Family of unknown function (DUF5365)
PFKLECOI_00897 2.9e-67 yhcV S COG0517 FOG CBS domain
PFKLECOI_00898 1.3e-119 yhcW 5.4.2.6 S hydrolase
PFKLECOI_00899 1.7e-303 yhcX 3.5.1.3 K Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
PFKLECOI_00900 5.1e-259 yhxA E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PFKLECOI_00901 5.2e-104 glpP K Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
PFKLECOI_00902 1.9e-152 glpF G Belongs to the MIP aquaporin (TC 1.A.8) family
PFKLECOI_00903 4.6e-293 glpK 2.7.1.30 C Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PFKLECOI_00904 0.0 glpD 1.1.5.3 C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
PFKLECOI_00905 0.0 pmmB 5.4.2.2, 5.4.2.8 G Phosphoglucomutase
PFKLECOI_00906 2.7e-213 yhcY 2.7.13.3 T Histidine kinase
PFKLECOI_00907 1.7e-111 yhcZ K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
PFKLECOI_00908 2.7e-83 azr 1.7.1.6 S NADPH-dependent FMN reductase
PFKLECOI_00909 1.2e-38 yhdB S YhdB-like protein
PFKLECOI_00910 4.8e-54 yhdC S Protein of unknown function (DUF3889)
PFKLECOI_00911 1.5e-187 cwlS 3.5.1.28 CBM50 M COG1388 FOG LysM repeat
PFKLECOI_00912 1e-75 nsrR K Transcriptional regulator
PFKLECOI_00913 3.3e-238 ygxB M Conserved TM helix
PFKLECOI_00914 2.1e-276 ycgB S Stage V sporulation protein R
PFKLECOI_00915 1.2e-255 phoB 3.1.3.1 P Belongs to the alkaline phosphatase family
PFKLECOI_00916 2.5e-141 lytE 3.5.1.28 CBM50 M COG1388 FOG LysM repeat
PFKLECOI_00917 3.8e-162 citR K Transcriptional regulator
PFKLECOI_00918 1.2e-205 citA 2.3.3.1 C Belongs to the citrate synthase family
PFKLECOI_00919 1.7e-159 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
PFKLECOI_00920 3.4e-250 yhdG E amino acid
PFKLECOI_00921 1.5e-242 yhdH S Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
PFKLECOI_00922 3.1e-178 ydeL K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
PFKLECOI_00923 1.7e-68 ydeL K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
PFKLECOI_00924 1.7e-75 BH1582 K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
PFKLECOI_00925 8.1e-45 yhdK S Sigma-M inhibitor protein
PFKLECOI_00926 6.6e-201 yhdL S Sigma factor regulator N-terminal
PFKLECOI_00927 5.5e-86 sigM K Belongs to the sigma-70 factor family. ECF subfamily
PFKLECOI_00928 1.5e-191 yhdN C Aldo keto reductase
PFKLECOI_00929 3e-110 plsC 2.3.1.51 I Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family
PFKLECOI_00930 3.1e-240 corC1 S COG1253 Hemolysins and related proteins containing CBS domains
PFKLECOI_00931 4.1e-74 cueR K transcriptional
PFKLECOI_00932 2e-222 yhdR 2.6.1.1 E Aminotransferase
PFKLECOI_00933 2.5e-245 corC1 P COG1253 Hemolysins and related proteins containing CBS domains
PFKLECOI_00934 1.3e-44 crcB D Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PFKLECOI_00935 9.6e-65 crcB D Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PFKLECOI_00936 1.8e-133 yhdW 3.1.4.46 C glycerophosphoryl diester phosphodiesterase
PFKLECOI_00938 5.6e-203 yhdY M Mechanosensitive ion channel
PFKLECOI_00939 8.5e-139 cobB K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form
PFKLECOI_00940 1.7e-151 yheN G deacetylase
PFKLECOI_00941 1.8e-153 dat 2.6.1.21 E Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha- keto acid in the first half-reaction
PFKLECOI_00942 1.2e-231 nhaC C Na H antiporter
PFKLECOI_00943 3.4e-84 nhaX T Belongs to the universal stress protein A family
PFKLECOI_00944 0.0 yheI V COG1132 ABC-type multidrug transport system, ATPase and permease components
PFKLECOI_00945 0.0 yheH V COG1132 ABC-type multidrug transport system, ATPase and permease components
PFKLECOI_00946 3.7e-111 yheG GM NAD(P)H-binding
PFKLECOI_00947 6.3e-28 sspB S spore protein
PFKLECOI_00948 1.3e-36 yheE S Family of unknown function (DUF5342)
PFKLECOI_00949 1.6e-268 gshB 6.3.2.2, 6.3.2.3 HJ YheC/D like ATP-grasp
PFKLECOI_00950 6.2e-215 yheC HJ YheC/D like ATP-grasp
PFKLECOI_00951 3.1e-201 yheB S Belongs to the UPF0754 family
PFKLECOI_00952 9.5e-48 yheA S Belongs to the UPF0342 family
PFKLECOI_00953 1.5e-205 yhaZ L DNA alkylation repair enzyme
PFKLECOI_00954 4.3e-142 yhaX S haloacid dehalogenase-like hydrolase
PFKLECOI_00955 1.8e-292 hemZ H coproporphyrinogen III oxidase
PFKLECOI_00956 2.8e-208 yhaU P COG0475 Kef-type K transport systems, membrane components
PFKLECOI_00957 7.8e-88 yhaT P regulatory, ligand-binding protein related to C-terminal domains of K channels
PFKLECOI_00959 4.9e-132 yhaR 5.3.3.18 I enoyl-CoA hydratase
PFKLECOI_00960 1.1e-26 S YhzD-like protein
PFKLECOI_00961 2.2e-165 yhaQ S ABC transporter, ATP-binding protein
PFKLECOI_00962 2.7e-214 yhaP CP COG1668 ABC-type Na efflux pump, permease component
PFKLECOI_00963 1e-226 yhaO L DNA repair exonuclease
PFKLECOI_00964 0.0 yhaN L AAA domain
PFKLECOI_00965 1.5e-177 yhaM L Shows a 3'-5' exoribonuclease activity
PFKLECOI_00966 1.6e-21 yhaL S Sporulation protein YhaL
PFKLECOI_00967 1.9e-121 prsA 5.2.1.8 M plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins
PFKLECOI_00968 8.7e-90 yhaK S Putative zincin peptidase
PFKLECOI_00969 1.3e-54 yhaI S Protein of unknown function (DUF1878)
PFKLECOI_00970 1e-113 hpr K Negative regulator of protease production and sporulation
PFKLECOI_00971 7e-39 yhaH S YtxH-like protein
PFKLECOI_00972 5.4e-21
PFKLECOI_00973 3.6e-80 trpP S Tryptophan transporter TrpP
PFKLECOI_00974 8.4e-204 serC 2.6.1.52 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
PFKLECOI_00975 4.7e-81 hit FG COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
PFKLECOI_00976 1.8e-136 ecsA V transporter (ATP-binding protein)
PFKLECOI_00977 1e-213 ecsB U ABC transporter
PFKLECOI_00978 3.4e-113 ecsC S EcsC protein family
PFKLECOI_00979 2.4e-228 yhaA 3.5.1.47 E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
PFKLECOI_00980 1.6e-231 yhfA C membrane
PFKLECOI_00981 7.8e-33 1.15.1.2 C Rubrerythrin
PFKLECOI_00982 1.3e-90 traP 1.14.99.57, 6.2.1.3 S enzyme involved in biosynthesis of extracellular polysaccharides
PFKLECOI_00983 0.0 pbpF 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
PFKLECOI_00984 1.7e-204 hemE 4.1.1.37 H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PFKLECOI_00985 3.6e-179 hemH 4.99.1.1, 4.99.1.9 H Catalyzes the ferrous insertion into protoporphyrin IX
PFKLECOI_00986 1.7e-268 hemG 1.14.19.9, 1.3.3.15, 1.3.3.4 H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
PFKLECOI_00987 5.4e-101 yhgD K Transcriptional regulator
PFKLECOI_00988 3.5e-215 yhgE S YhgE Pip N-terminal domain protein
PFKLECOI_00989 1.1e-183 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PFKLECOI_00990 1.4e-136 yhfC S Putative membrane peptidase family (DUF2324)
PFKLECOI_00991 3e-198 yhfE 3.2.1.4 GH5,GH9 G peptidase M42
PFKLECOI_00992 3.7e-72 3.4.13.21 S ASCH
PFKLECOI_00993 3.8e-227 gltP C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
PFKLECOI_00994 3.1e-141 yhfI S COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III
PFKLECOI_00995 1.7e-190 lplJ 6.3.1.20 H Lipoate-protein ligase
PFKLECOI_00996 5e-111 yhfK GM NmrA-like family
PFKLECOI_00997 2e-299 fadD 6.2.1.3 IQ AMP-binding enzyme C-terminal domain
PFKLECOI_00998 1.9e-65 yhfM
PFKLECOI_00999 5.4e-242 yhfN 3.4.24.84 O Peptidase M48
PFKLECOI_01000 8e-197 aprE 3.4.21.62 O Belongs to the peptidase S8 family
PFKLECOI_01001 4.3e-77 VY92_01935 K acetyltransferase
PFKLECOI_01002 2.4e-181 yhfP 1.1.1.1 C Quinone oxidoreductase
PFKLECOI_01003 4.3e-159 yfmC M Periplasmic binding protein
PFKLECOI_01004 2.1e-108 yhfR 3.1.3.73 G Belongs to the phosphoglycerate mutase family
PFKLECOI_01005 3.2e-195 vraB 2.3.1.9 I Belongs to the thiolase family
PFKLECOI_01006 2e-269 yhfT 6.2.1.3 IQ AMP-binding enzyme C-terminal domain
PFKLECOI_01007 1.1e-90 bioY S BioY family
PFKLECOI_01008 2.8e-182 hemAT NT chemotaxis protein
PFKLECOI_01009 1.6e-301 yhfW CE COG0665 Glycine D-amino acid oxidases (deaminating)
PFKLECOI_01010 1.6e-157 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
PFKLECOI_01011 1.3e-32 yhzC S IDEAL
PFKLECOI_01012 9.3e-109 comK K Competence transcription factor
PFKLECOI_01013 2.1e-168 IQ Enoyl-(Acyl carrier protein) reductase
PFKLECOI_01014 7.8e-42 yhjA S Excalibur calcium-binding domain
PFKLECOI_01015 5.7e-264 yhjB E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PFKLECOI_01016 6.9e-27 yhjC S Protein of unknown function (DUF3311)
PFKLECOI_01017 6.7e-60 yhjD
PFKLECOI_01018 9.1e-110 yhjE S SNARE associated Golgi protein
PFKLECOI_01019 3.4e-91 sipV 3.4.21.89 U Belongs to the peptidase S26 family
PFKLECOI_01020 9e-281 yhjG CH FAD binding domain
PFKLECOI_01021 1.2e-94 yhjH K helix_turn_helix multiple antibiotic resistance protein
PFKLECOI_01022 2.6e-214 glcP G Major Facilitator Superfamily
PFKLECOI_01023 3.2e-200 thuB 1.1.1.361 S Oxidoreductase family, C-terminal alpha/beta domain
PFKLECOI_01024 3.1e-161 ntdB 3.1.3.92 S Sucrose-6F-phosphate phosphohydrolase
PFKLECOI_01025 8.3e-254 ntdA 2.6.1.104 E Belongs to the DegT DnrJ EryC1 family
PFKLECOI_01026 5.9e-188 yhjM 5.1.1.1 K Transcriptional regulator
PFKLECOI_01027 4.2e-201 abrB S membrane
PFKLECOI_01028 7.6e-214 EGP Transmembrane secretion effector
PFKLECOI_01029 0.0 S Sugar transport-related sRNA regulator N-term
PFKLECOI_01030 8.4e-78 yhjR S Rubrerythrin
PFKLECOI_01031 0.0 addB 3.1.21.3, 3.6.4.12 L ATP-dependent helicase deoxyribonuclease subunit B
PFKLECOI_01032 0.0 addA 3.6.4.12 L ATP-dependent helicase nuclease subunit A
PFKLECOI_01033 2e-219 sbcD L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
PFKLECOI_01034 0.0 sbcC L COG0419 ATPase involved in DNA repair
PFKLECOI_01035 1.1e-49 yisB V COG1403 Restriction endonuclease
PFKLECOI_01036 4.5e-32 gerPF S Spore germination protein gerPA/gerPF
PFKLECOI_01037 3e-66 gerPE S Spore germination protein GerPE
PFKLECOI_01038 6.3e-24 gerPD S Spore germination protein
PFKLECOI_01039 5.3e-54 gerPC S Spore germination protein
PFKLECOI_01040 4e-34 gerPB S cell differentiation
PFKLECOI_01041 1.9e-33 gerPA S Spore germination protein
PFKLECOI_01042 1.5e-22 yisI S Spo0E like sporulation regulatory protein
PFKLECOI_01043 1e-173 cotH M Spore Coat
PFKLECOI_01044 7.1e-172 yisK Q COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)
PFKLECOI_01045 3e-57 yisL S UPF0344 protein
PFKLECOI_01046 0.0 wprA O Belongs to the peptidase S8 family
PFKLECOI_01047 3.6e-102 yisN S Protein of unknown function (DUF2777)
PFKLECOI_01048 0.0 asnO 6.3.5.4 E Asparagine synthase
PFKLECOI_01049 4.7e-88 yizA S Damage-inducible protein DinB
PFKLECOI_01050 2.4e-147 crtB 2.5.1.21, 2.5.1.32, 2.5.1.99 I phytoene
PFKLECOI_01051 4e-243 yisQ V Mate efflux family protein
PFKLECOI_01052 1.2e-160 yisR K Transcriptional regulator
PFKLECOI_01053 2.4e-184 purR K helix_turn _helix lactose operon repressor
PFKLECOI_01054 5.2e-195 yisS 1.1.1.370 S Oxidoreductase family, C-terminal alpha/beta domain
PFKLECOI_01055 7e-92 yisT S DinB family
PFKLECOI_01056 1.4e-99 argO S Lysine exporter protein LysE YggA
PFKLECOI_01057 2.6e-269 yisV K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
PFKLECOI_01058 4e-36 mcbG S Pentapeptide repeats (9 copies)
PFKLECOI_01059 3.1e-155 yisY I hydrolases or acyltransferases (alpha beta hydrolase superfamily)
PFKLECOI_01060 4.9e-113 cysC 1.8.4.10, 1.8.4.8, 2.7.1.25, 2.7.7.4 P Catalyzes the synthesis of activated sulfate
PFKLECOI_01061 2.7e-232 sat 2.7.7.4 P Belongs to the sulfate adenylyltransferase family
PFKLECOI_01062 2.5e-140 cysH 1.8.4.10, 1.8.4.8, 2.7.1.25 EH Belongs to the PAPS reductase family. CysH subfamily
PFKLECOI_01063 4.9e-125 comB 3.1.3.71 H Belongs to the ComB family
PFKLECOI_01064 1.9e-141 yitD 4.4.1.19 S synthase
PFKLECOI_01065 7.2e-113 yitE S Uncharacterised 5xTM membrane BCR, YitT family COG1284
PFKLECOI_01066 5.6e-219 yitF 5.5.1.27 M Belongs to the mandelate racemase muconate lactonizing enzyme family
PFKLECOI_01067 1.5e-228 yitG EGP Major facilitator Superfamily
PFKLECOI_01068 9.3e-150 yitH K Acetyltransferase (GNAT) domain
PFKLECOI_01069 1.7e-70 yjcF S Acetyltransferase (GNAT) domain
PFKLECOI_01070 0.0 yitJ 1.5.1.20, 2.1.1.10, 2.1.1.13 E Catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine
PFKLECOI_01071 4.3e-54 yajQ S Belongs to the UPF0234 family
PFKLECOI_01072 6.9e-161 cvfB S protein conserved in bacteria
PFKLECOI_01073 8.5e-94
PFKLECOI_01074 3.6e-171
PFKLECOI_01075 1.5e-97 S Sporulation delaying protein SdpA
PFKLECOI_01076 1.5e-58 K Transcriptional regulator PadR-like family
PFKLECOI_01077 2.9e-94
PFKLECOI_01078 1.4e-44 yitR S Domain of unknown function (DUF3784)
PFKLECOI_01079 3.8e-309 nprB 3.4.24.28 E Peptidase M4
PFKLECOI_01080 3.5e-157 yitS S protein conserved in bacteria
PFKLECOI_01081 6.6e-148 yitT S Uncharacterized protein conserved in bacteria (DUF2179)
PFKLECOI_01082 5e-73 ipi S Intracellular proteinase inhibitor
PFKLECOI_01083 1.2e-17 S Protein of unknown function (DUF3813)
PFKLECOI_01085 2.1e-154 yitU 3.1.3.104 S hydrolases of the HAD superfamily
PFKLECOI_01086 3.8e-142 yjfP S COG1073 Hydrolases of the alpha beta superfamily
PFKLECOI_01087 6.2e-51 yitW S metal-sulfur cluster biosynthetic enzyme
PFKLECOI_01088 1.5e-22 pilT S Proteolipid membrane potential modulator
PFKLECOI_01089 1e-265 yitY C D-arabinono-1,4-lactone oxidase
PFKLECOI_01090 1.7e-88 norB G Major Facilitator Superfamily
PFKLECOI_01091 1.1e-197 argC 1.2.1.38 E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PFKLECOI_01092 3.1e-231 argJ 2.3.1.1, 2.3.1.35, 2.7.2.8 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
PFKLECOI_01093 2.7e-135 argB 2.7.2.8 E Belongs to the acetylglutamate kinase family. ArgB subfamily
PFKLECOI_01094 1.3e-218 argD 2.6.1.11, 2.6.1.17 E acetylornithine aminotransferase
PFKLECOI_01095 9.7e-205 carA 6.3.5.5 F Carbamoyl-phosphate synthetase glutamine chain
PFKLECOI_01096 0.0 carB 6.3.5.5 EF Carbamoyl-phosphate synthetase ammonia chain
PFKLECOI_01097 1.6e-174 argF 2.1.3.3 E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PFKLECOI_01098 9.5e-28 yjzC S YjzC-like protein
PFKLECOI_01099 2.3e-16 yjzD S Protein of unknown function (DUF2929)
PFKLECOI_01100 6.8e-141 yjaU I carboxylic ester hydrolase activity
PFKLECOI_01101 1.5e-100 yjaV
PFKLECOI_01102 2.5e-183 med S Transcriptional activator protein med
PFKLECOI_01103 7.3e-26 comZ S ComZ
PFKLECOI_01104 2.4e-20 yjzB
PFKLECOI_01105 3.9e-173 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PFKLECOI_01106 1.8e-234 fabF 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
PFKLECOI_01107 1.5e-149 yjaZ O Zn-dependent protease
PFKLECOI_01108 1.8e-184 appD P Belongs to the ABC transporter superfamily
PFKLECOI_01109 3.6e-185 appF E Belongs to the ABC transporter superfamily
PFKLECOI_01110 2.4e-287 appA E COG0747 ABC-type dipeptide transport system, periplasmic component
PFKLECOI_01111 7.7e-169 oppB P COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
PFKLECOI_01112 7.9e-163 appC EP COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
PFKLECOI_01113 5e-147 yjbA S Belongs to the UPF0736 family
PFKLECOI_01114 6.1e-185 trpS 6.1.1.2 J Tryptophanyl-tRNA synthetase
PFKLECOI_01115 0.0 oppA E ABC transporter substrate-binding protein
PFKLECOI_01116 2.7e-166 oppB P COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
PFKLECOI_01117 7.7e-166 oppC EP COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
PFKLECOI_01118 1.5e-197 oppD P Belongs to the ABC transporter superfamily
PFKLECOI_01119 5.5e-172 oppF E Belongs to the ABC transporter superfamily
PFKLECOI_01120 8.6e-196 yjbB EGP Major Facilitator Superfamily
PFKLECOI_01121 2.6e-103 yjbC K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
PFKLECOI_01122 3.5e-67 spxA 1.20.4.1 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
PFKLECOI_01123 6e-112 yjbE P Integral membrane protein TerC family
PFKLECOI_01124 4.4e-115 mecA NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC
PFKLECOI_01125 4.7e-221 yjbF S Competence protein
PFKLECOI_01126 0.0 pepF E oligoendopeptidase F
PFKLECOI_01127 1.8e-20
PFKLECOI_01129 3.3e-169 yjbH Q dithiol-disulfide isomerase involved in polyketide biosynthesis
PFKLECOI_01130 3.7e-72 yjbI S Bacterial-like globin
PFKLECOI_01131 7e-85 yjbJ M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)
PFKLECOI_01132 1.2e-100 yjbK S protein conserved in bacteria
PFKLECOI_01133 7.1e-62 yjbL S Belongs to the UPF0738 family
PFKLECOI_01134 2.6e-112 yjbM 2.7.6.5 S GTP pyrophosphokinase
PFKLECOI_01135 2.1e-151 nadK 2.7.1.23 G Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PFKLECOI_01136 1.2e-158 yjbO 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
PFKLECOI_01137 5.1e-128 prpE 3.1.3.16, 3.6.1.41 T Asymmetrically hydrolyzes Ap4p to yield AMP and ATP
PFKLECOI_01138 0.0 yjbQ P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
PFKLECOI_01139 4.4e-137 tenA 3.5.99.2 K Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
PFKLECOI_01140 1.2e-106 tenI 2.5.1.3, 5.3.99.10 H Transcriptional regulator TenI
PFKLECOI_01141 2.2e-215 thiO 1.4.3.19 E Glycine oxidase
PFKLECOI_01142 6.7e-30 thiS H thiamine diphosphate biosynthetic process
PFKLECOI_01143 1.5e-135 thiG 2.8.1.10 H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S
PFKLECOI_01144 6.7e-187 thiF 2.7.7.73, 2.7.7.80 H COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
PFKLECOI_01145 2e-149 thiD 2.5.1.3, 2.7.1.35, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Phosphomethylpyrimidine kinase
PFKLECOI_01146 3.2e-141 fabI 1.3.1.10, 1.3.1.9 I Enoyl- acyl-carrier-protein reductase NADH
PFKLECOI_01147 1.4e-52 yjbX S Spore coat protein
PFKLECOI_01148 8.9e-83 cotZ S Spore coat protein
PFKLECOI_01149 3.4e-96 cotY S Spore coat protein Z
PFKLECOI_01150 3.6e-72 cotX S Spore Coat Protein X and V domain
PFKLECOI_01151 5.5e-26 cotW
PFKLECOI_01152 5.3e-52 cotV S Spore Coat Protein X and V domain
PFKLECOI_01153 9.6e-56 yjcA S Protein of unknown function (DUF1360)
PFKLECOI_01156 2.9e-38 spoVIF S Stage VI sporulation protein F
PFKLECOI_01157 0.0 yjcD 3.6.4.12 L DNA helicase
PFKLECOI_01158 1.7e-38
PFKLECOI_01159 8.7e-72 yjcF S COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
PFKLECOI_01160 2.9e-93 yjcG J Belongs to the 2H phosphoesterase superfamily. YjcG family
PFKLECOI_01161 3.8e-136 yjcH P COG2382 Enterochelin esterase and related enzymes
PFKLECOI_01162 3.8e-215 metB 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
PFKLECOI_01163 8.5e-218 metC 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
PFKLECOI_01164 2.9e-96 rimJ 2.3.1.128 J Alanine acetyltransferase
PFKLECOI_01165 5.4e-212 yjcL S Protein of unknown function (DUF819)
PFKLECOI_01167 8.7e-18
PFKLECOI_01168 5.4e-32
PFKLECOI_01169 1.9e-30
PFKLECOI_01170 2.1e-250 M nucleic acid phosphodiester bond hydrolysis
PFKLECOI_01171 8.3e-21
PFKLECOI_01174 5e-124 S response regulator aspartate phosphatase
PFKLECOI_01175 4.2e-46 yjcS S Antibiotic biosynthesis monooxygenase
PFKLECOI_01176 2.3e-139 IQ Enoyl-(Acyl carrier protein) reductase
PFKLECOI_01178 0.0 manR 2.7.1.200, 2.7.1.202 GKT transcriptional antiterminator
PFKLECOI_01179 0.0 manP 2.7.1.191, 2.7.1.202 G phosphotransferase system
PFKLECOI_01180 5.6e-188 manA 5.3.1.8 G mannose-6-phosphate isomerase
PFKLECOI_01181 5.9e-49 yjdF S Protein of unknown function (DUF2992)
PFKLECOI_01182 5.9e-91 yjdG 2.3.1.128 J Acetyltransferase (GNAT) domain
PFKLECOI_01184 2.3e-81 ybaK S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PFKLECOI_01185 9.9e-29 S Domain of unknown function (DUF4177)
PFKLECOI_01186 2.7e-52 yjdJ S Domain of unknown function (DUF4306)
PFKLECOI_01187 3.6e-174 cyoE 2.5.1.141 O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
PFKLECOI_01189 4.9e-265 xynD 3.5.1.104 G Polysaccharide deacetylase
PFKLECOI_01190 5.5e-83 S Protein of unknown function (DUF2690)
PFKLECOI_01191 2.3e-20 yjfB S Putative motility protein
PFKLECOI_01192 1.6e-171 yjfC O Predicted Zn-dependent protease (DUF2268)
PFKLECOI_01193 1.2e-45 T PhoQ Sensor
PFKLECOI_01194 5.8e-103 yjgB S Domain of unknown function (DUF4309)
PFKLECOI_01195 0.0 yjgC 1.17.1.10, 1.17.1.9 C formate dehydrogenase (NAD+) activity
PFKLECOI_01196 1.6e-94 yjgD S Protein of unknown function (DUF1641)
PFKLECOI_01197 8.7e-07 S Domain of unknown function (DUF4352)
PFKLECOI_01198 7.1e-115 yjhB 3.6.1.13, 3.6.1.55 F ADP-ribose pyrophosphatase
PFKLECOI_01200 9.8e-222 yjiB 1.14.13.154, 1.14.15.8 C Cytochrome P450
PFKLECOI_01201 2.2e-218 oleD GT1 CG COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase
PFKLECOI_01202 8.2e-30
PFKLECOI_01203 4.3e-144 hemD 2.1.1.107, 4.2.1.75 H Uroporphyrinogen-III synthase
PFKLECOI_01204 9.5e-122 ybbM S transport system, permease component
PFKLECOI_01205 5.2e-136 pstB 3.6.3.27 P ATPases associated with a variety of cellular activities
PFKLECOI_01206 6.7e-176 yjlA EG Putative multidrug resistance efflux transporter
PFKLECOI_01207 2e-91 yjlB S Cupin domain
PFKLECOI_01208 7.1e-66 yjlC S Protein of unknown function (DUF1641)
PFKLECOI_01209 2.6e-219 yjlD 1.6.99.3 C NADH dehydrogenase
PFKLECOI_01210 3e-278 uxaC 5.3.1.12 G glucuronate isomerase
PFKLECOI_01211 1.4e-248 yjmB G symporter YjmB
PFKLECOI_01212 1.9e-186 yjmC 1.1.1.350 C Belongs to the LDH2 MDH2 oxidoreductase family
PFKLECOI_01213 1.4e-189 rspB 1.1.1.380 E Alcohol dehydrogenase GroES-like domain
PFKLECOI_01214 8.9e-214 uxuA 4.2.1.8 G Catalyzes the dehydration of D-mannonate
PFKLECOI_01215 6.8e-153 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
PFKLECOI_01216 1.1e-226 exuT G Sugar (and other) transporter
PFKLECOI_01217 8.9e-184 exuR K transcriptional
PFKLECOI_01218 1.7e-281 uxaB 1.1.1.17, 1.1.1.58 G tagaturonate reductase activity
PFKLECOI_01219 8.4e-287 uxaA 4.2.1.7, 4.4.1.24 G Altronate
PFKLECOI_01220 4.3e-130 MA20_18170 S membrane transporter protein
PFKLECOI_01221 2.3e-78 yjoA S DinB family
PFKLECOI_01222 1.4e-245 ftsH2 3.4.21.53 O AAA domain (dynein-related subfamily)
PFKLECOI_01223 1e-212 S response regulator aspartate phosphatase
PFKLECOI_01225 2e-39 S YCII-related domain
PFKLECOI_01226 5.4e-162 xlyA 3.5.1.28 CBM50 M N-acetylmuramoyl-L-alanine amidase
PFKLECOI_01227 6.1e-61 yjqA S Bacterial PH domain
PFKLECOI_01228 2.1e-111 yjqB S Pfam:DUF867
PFKLECOI_01229 4.4e-160 ydbD P Catalase
PFKLECOI_01230 2.3e-110 xkdA E IrrE N-terminal-like domain
PFKLECOI_01231 3.2e-56 xre K Helix-turn-helix XRE-family like proteins
PFKLECOI_01233 1.9e-155 xkdB K sequence-specific DNA binding
PFKLECOI_01234 4.1e-118 xkdC L Bacterial dnaA protein
PFKLECOI_01237 4.6e-10 yqaO S Phage-like element PBSX protein XtrA
PFKLECOI_01238 4.1e-84 xpf K COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog
PFKLECOI_01239 5.3e-139 xtmA L phage terminase small subunit
PFKLECOI_01240 6.9e-253 xtmB S phage terminase, large subunit
PFKLECOI_01241 4.6e-285 yqbA S portal protein
PFKLECOI_01242 1.2e-133 yqbD 2.1.1.72 L Putative phage serine protease XkdF
PFKLECOI_01243 5.8e-169 xkdG S Phage capsid family
PFKLECOI_01244 6.2e-61 yqbG S Protein of unknown function (DUF3199)
PFKLECOI_01245 1.2e-63 yqbH S Domain of unknown function (DUF3599)
PFKLECOI_01246 1.1e-86 xkdI S Bacteriophage HK97-gp10, putative tail-component
PFKLECOI_01247 6.7e-75 xkdJ
PFKLECOI_01248 2.5e-256 xkdK S Phage tail sheath C-terminal domain
PFKLECOI_01249 6.1e-76 xkdM S Phage tail tube protein
PFKLECOI_01250 1.9e-77 S Phage XkdN-like tail assembly chaperone protein, TAC
PFKLECOI_01251 0.0 xkdO L Transglycosylase SLT domain
PFKLECOI_01252 9.2e-121 xkdP S Lysin motif
PFKLECOI_01253 4.8e-182 yqbQ 3.2.1.96 G NLP P60 protein
PFKLECOI_01254 2.1e-39 xkdR S Protein of unknown function (DUF2577)
PFKLECOI_01255 3.4e-68 xkdS S Protein of unknown function (DUF2634)
PFKLECOI_01256 6e-191 xkdT S Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
PFKLECOI_01257 9.9e-103 xkdU S Uncharacterised protein conserved in bacteria (DUF2313)
PFKLECOI_01258 1.5e-40
PFKLECOI_01259 0.0
PFKLECOI_01260 9.1e-45 xkdW S XkdW protein
PFKLECOI_01261 4.2e-22 xkdX
PFKLECOI_01262 9.9e-152 xepA
PFKLECOI_01263 2.8e-39 xhlA S Haemolysin XhlA
PFKLECOI_01264 1.3e-38 xhlB S SPP1 phage holin
PFKLECOI_01265 3.8e-162 xlyA 3.5.1.28 M n-acetylmuramoyl-L-alanine amidase
PFKLECOI_01266 6.7e-23 spoIISB S Stage II sporulation protein SB
PFKLECOI_01267 1.8e-136 spoIISA S Toxin SpoIISA, type II toxin-antitoxin system
PFKLECOI_01268 5.8e-175 pit P phosphate transporter
PFKLECOI_01269 6.9e-110 ykaA P COG1392 Phosphate transport regulator (distant homolog of PhoU)
PFKLECOI_01270 2.3e-240 steT E amino acid
PFKLECOI_01271 1.8e-181 mhqA E COG0346 Lactoylglutathione lyase and related lyases
PFKLECOI_01272 0.0 ykcB M COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PFKLECOI_01273 1.9e-178 ykcC GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
PFKLECOI_01275 8.5e-214 htrA 3.4.21.107 O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PFKLECOI_01276 1.4e-134 proG 1.5.1.2 E Pyrroline-5-carboxylate reductase
PFKLECOI_01277 3.3e-152 dppA E D-aminopeptidase
PFKLECOI_01278 1.1e-159 dppB P COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
PFKLECOI_01279 3.3e-175 dppC EP COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
PFKLECOI_01280 1.3e-187 dppD P Belongs to the ABC transporter superfamily
PFKLECOI_01281 0.0 dppE E ABC transporter substrate-binding protein
PFKLECOI_01283 4.2e-175 ykfA 3.4.17.13 V proteins, homologs of microcin C7 resistance protein MccF
PFKLECOI_01284 6.3e-199 ykfB 5.1.1.20 M Belongs to the mandelate racemase muconate lactonizing enzyme family
PFKLECOI_01285 1e-162 ykfC 3.4.14.13 M COG0791 Cell wall-associated hydrolases (invasion-associated proteins)
PFKLECOI_01286 9.4e-186 ykfD E Belongs to the ABC transporter superfamily
PFKLECOI_01287 4.5e-202 pgl 3.1.1.31 G 6-phosphogluconolactonase
PFKLECOI_01288 2.2e-159 ykgA E Amidinotransferase
PFKLECOI_01289 3.4e-92 ykhA 3.1.2.20 I Acyl-CoA hydrolase
PFKLECOI_01290 1.7e-226 hmp 1.14.12.17 C Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PFKLECOI_01291 7.2e-09
PFKLECOI_01292 2.3e-128 ykjA S Protein of unknown function (DUF421)
PFKLECOI_01293 3.3e-97 ykkA S Protein of unknown function (DUF664)
PFKLECOI_01294 1.7e-98 ykkB 2.3.1.128 J COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
PFKLECOI_01295 3.5e-55 ykkC P Multidrug resistance protein
PFKLECOI_01296 7e-50 ykkD P Multidrug resistance protein
PFKLECOI_01297 1.9e-169 purU 2.7.7.72, 3.5.1.10 F Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)
PFKLECOI_01298 5.2e-201 proB 2.7.2.11 E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PFKLECOI_01299 2.5e-228 proA 1.2.1.41, 1.2.1.81 E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PFKLECOI_01300 1.3e-70 ohrA O Organic hydroperoxide resistance protein
PFKLECOI_01301 4.4e-74 ohrR K COG1846 Transcriptional regulators
PFKLECOI_01302 1.9e-71 ohrB O Organic hydroperoxide resistance protein
PFKLECOI_01303 2.8e-87 guaD 3.5.4.12, 3.5.4.3, 3.5.4.33 FJ COG0590 Cytosine adenosine deaminases
PFKLECOI_01304 0.0 metE 2.1.1.14 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
PFKLECOI_01305 5e-176 isp O Belongs to the peptidase S8 family
PFKLECOI_01306 6.3e-151 T COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
PFKLECOI_01307 5.8e-135 ykoC P Cobalt transport protein
PFKLECOI_01308 3e-306 P ABC transporter, ATP-binding protein
PFKLECOI_01309 2e-98 ykoE S ABC-type cobalt transport system, permease component
PFKLECOI_01310 3.3e-109 ykoF S YKOF-related Family
PFKLECOI_01311 1.6e-123 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
PFKLECOI_01312 1.4e-240 ykoH 2.7.13.3 T Histidine kinase
PFKLECOI_01313 1.4e-111 ykoI S Peptidase propeptide and YPEB domain
PFKLECOI_01314 2.2e-85 ykoJ S Peptidase propeptide and YPEB domain
PFKLECOI_01317 2.2e-222 mgtE P Acts as a magnesium transporter
PFKLECOI_01318 1.4e-53 tnrA K transcriptional
PFKLECOI_01319 5.9e-18
PFKLECOI_01320 6.9e-26 ykoL
PFKLECOI_01321 1.3e-81 mhqR K transcriptional
PFKLECOI_01322 5e-212 ugtP 2.4.1.315 GT28 M COG0707 UDP-N-acetylglucosamine LPS N-acetylglucosamine transferase
PFKLECOI_01323 1.1e-98 ykoP G polysaccharide deacetylase
PFKLECOI_01324 7.1e-155 ykoQ S Calcineurin-like phosphoesterase superfamily domain
PFKLECOI_01325 0.0 ykoS
PFKLECOI_01326 2.5e-186 ykoT GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
PFKLECOI_01327 0.0 ligD 6.5.1.1 L ATP-dependent DNA ligase
PFKLECOI_01328 3.2e-161 ku L With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
PFKLECOI_01329 0.0 ydcR 2.7.7.65 T Diguanylate cyclase
PFKLECOI_01330 5.4e-110 ykoX S membrane-associated protein
PFKLECOI_01331 8.7e-176 ykoY P COG0861 Membrane protein TerC, possibly involved in tellurium resistance
PFKLECOI_01332 9.5e-130 sigI K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PFKLECOI_01333 1.2e-112 rsgI S Anti-sigma factor N-terminus
PFKLECOI_01334 1.9e-26 sspD S small acid-soluble spore protein
PFKLECOI_01335 1.9e-124 ykrK S Domain of unknown function (DUF1836)
PFKLECOI_01336 1.7e-154 htpX O Belongs to the peptidase M48B family
PFKLECOI_01337 1.7e-233 ktrB P COG0168 Trk-type K transport systems, membrane components
PFKLECOI_01338 1.2e-10 ydfR S Protein of unknown function (DUF421)
PFKLECOI_01339 6.3e-19 ykzE
PFKLECOI_01340 6.5e-190 ykrP G COG3594 Fucose 4-O-acetylase and related acetyltransferases
PFKLECOI_01341 0.0 kinE 2.7.13.3 T Histidine kinase
PFKLECOI_01342 7e-89 ogt 2.1.1.63 L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PFKLECOI_01344 5.3e-195 mtnA 5.3.1.23 E Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
PFKLECOI_01345 2.4e-228 mtnK 2.7.1.100 F Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
PFKLECOI_01346 1e-150 mtnU 3.5.1.3 S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
PFKLECOI_01347 2e-227 mtnE 2.6.1.83 E Aminotransferase
PFKLECOI_01348 1.2e-230 mtnW 5.3.2.5 G Catalyzes the enolization of 2,3-diketo-5- methylthiopentyl-1-phosphate (DK-MTP-1-P) into 2-hydroxy-3-keto-5- methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P)
PFKLECOI_01349 8.3e-136 mtnX 3.1.3.87, 4.2.1.109 E Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
PFKLECOI_01350 8e-114 mtnB 3.1.3.87, 4.1.2.17, 4.2.1.109, 5.1.3.4 E Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P)
PFKLECOI_01351 8.4e-96 mtnD 1.13.11.53, 1.13.11.54 S Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
PFKLECOI_01352 2.9e-51 XK27_09985 S Protein of unknown function (DUF1232)
PFKLECOI_01353 7.5e-10 S Spo0E like sporulation regulatory protein
PFKLECOI_01354 1.5e-63 eag
PFKLECOI_01355 4.8e-274 kinD 2.7.13.3 T COG0642 Signal transduction histidine kinase
PFKLECOI_01356 1.3e-75 ykvE K transcriptional
PFKLECOI_01357 2.5e-125 motB N Flagellar motor protein
PFKLECOI_01358 1e-137 motA N flagellar motor
PFKLECOI_01359 0.0 clpE O Belongs to the ClpA ClpB family
PFKLECOI_01360 1.8e-179 ykvI S membrane
PFKLECOI_01361 7.3e-126 queC 6.3.4.20 F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PFKLECOI_01362 2.8e-81 queD 4.1.2.50, 4.2.3.12 H synthase
PFKLECOI_01363 1.1e-138 queE 1.97.1.4, 4.3.99.3 H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
PFKLECOI_01364 2e-96 queF 1.7.1.13 S Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PFKLECOI_01365 3.4e-61 ykvN K Transcriptional regulator
PFKLECOI_01366 2.4e-133 IQ Enoyl-(Acyl carrier protein) reductase
PFKLECOI_01367 8.4e-215 ykvP 3.5.1.28 M Glycosyl transferases group 1
PFKLECOI_01368 3.5e-35 3.5.1.104 M LysM domain
PFKLECOI_01369 1.4e-162 G Glycosyl hydrolases family 18
PFKLECOI_01370 1.6e-45 ykvR S Protein of unknown function (DUF3219)
PFKLECOI_01371 6e-25 ykvS S protein conserved in bacteria
PFKLECOI_01372 2.8e-28
PFKLECOI_01373 1.7e-103 ykvT 3.5.1.28 M Cell Wall Hydrolase
PFKLECOI_01374 9.9e-239 ykvU S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
PFKLECOI_01375 1.6e-88 stoA CO thiol-disulfide
PFKLECOI_01376 0.0 cadA 3.6.3.3, 3.6.3.5 P COG2217 Cation transport ATPase
PFKLECOI_01377 2.3e-09
PFKLECOI_01378 4.8e-207 pepQ 3.4.13.9 E COG0006 Xaa-Pro aminopeptidase
PFKLECOI_01379 9.8e-180 ykvZ 5.1.1.1 K Transcriptional regulator
PFKLECOI_01381 7.6e-128 glcT K antiterminator
PFKLECOI_01382 0.0 ptsG 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
PFKLECOI_01383 2.1e-39 ptsH G phosphocarrier protein HPr
PFKLECOI_01384 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PFKLECOI_01385 7.2e-39 splA S Transcriptional regulator
PFKLECOI_01386 1.3e-201 splB 4.1.99.14 L Spore photoproduct lyase
PFKLECOI_01387 2e-126 ykwB 2.3.1.1 K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
PFKLECOI_01388 1.7e-258 mcpC NT chemotaxis protein
PFKLECOI_01389 5e-159 glxR 1.1.1.31, 1.1.1.60 I COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases
PFKLECOI_01390 8e-124 ykwD J protein with SCP PR1 domains
PFKLECOI_01391 0.0 mrdA 3.4.16.4 M Penicillin-binding Protein
PFKLECOI_01392 0.0 pilS 2.7.13.3 T Histidine kinase
PFKLECOI_01393 8.8e-223 patA 2.6.1.1 E Aminotransferase
PFKLECOI_01394 2.2e-15
PFKLECOI_01395 6.2e-168 cheV 2.7.13.3 T Chemotaxis protein CheV
PFKLECOI_01396 1.7e-84 ykyB S YkyB-like protein
PFKLECOI_01397 9.9e-236 ykuC EGP Major facilitator Superfamily
PFKLECOI_01398 1.8e-87 ykuD S protein conserved in bacteria
PFKLECOI_01399 4.7e-165 ykuE S Metallophosphoesterase
PFKLECOI_01400 4.9e-142 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
PFKLECOI_01401 5.2e-234 ykuI T Diguanylate phosphodiesterase
PFKLECOI_01402 3.9e-37 ykuJ S protein conserved in bacteria
PFKLECOI_01403 4.4e-94 ykuK S Ribonuclease H-like
PFKLECOI_01404 3.9e-27 ykzF S Antirepressor AbbA
PFKLECOI_01405 1.6e-76 ykuL S CBS domain
PFKLECOI_01406 3.5e-168 ccpC K Transcriptional regulator
PFKLECOI_01407 3.7e-87 fld C Flavodoxin domain
PFKLECOI_01408 1.6e-176 ykuO
PFKLECOI_01409 3.2e-80 fld C Flavodoxin
PFKLECOI_01410 1.4e-74 dapD 2.3.1.117, 2.3.1.89 E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
PFKLECOI_01411 5.8e-216 hipO 3.5.1.47 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
PFKLECOI_01412 9e-37 ykuS S Belongs to the UPF0180 family
PFKLECOI_01413 1.5e-141 ykuT M Mechanosensitive ion channel
PFKLECOI_01414 3.9e-101 ykuU O Alkyl hydroperoxide reductase
PFKLECOI_01415 6.3e-81 ykuV CO thiol-disulfide
PFKLECOI_01416 5.8e-95 rok K Repressor of ComK
PFKLECOI_01417 1.2e-145 yknT
PFKLECOI_01418 1.1e-109 mobA 2.7.7.77 H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
PFKLECOI_01419 1.4e-189 moeB 2.7.7.73, 2.7.7.80 H COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
PFKLECOI_01420 2.4e-245 moeA 2.10.1.1 H molybdopterin
PFKLECOI_01421 6.7e-90 mobB 2.10.1.1, 2.7.7.77 H molybdopterin-guanine dinucleotide biosynthesis protein
PFKLECOI_01422 9.4e-83 moaE 2.8.1.12 H COG0314 Molybdopterin converting factor, large subunit
PFKLECOI_01423 2.8e-32 moaD 2.8.1.12 H Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
PFKLECOI_01424 0.0 yknU V COG1132 ABC-type multidrug transport system, ATPase and permease components
PFKLECOI_01425 0.0 yknV V COG1132 ABC-type multidrug transport system, ATPase and permease components
PFKLECOI_01426 2.9e-117 yknW S Yip1 domain
PFKLECOI_01427 4.3e-158 acrA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PFKLECOI_01428 2.5e-124 macB V ABC transporter, ATP-binding protein
PFKLECOI_01429 5.6e-209 yknZ V COG0577 ABC-type antimicrobial peptide transport system, permease component
PFKLECOI_01430 3.1e-136 fruR K Transcriptional regulator
PFKLECOI_01431 9e-167 fruK 2.7.1.11, 2.7.1.56 G Belongs to the carbohydrate kinase PfkB family
PFKLECOI_01432 0.0 fruA 2.7.1.202 GT COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type)
PFKLECOI_01433 3.1e-104 sipT 3.4.21.89 U Belongs to the peptidase S26 family
PFKLECOI_01434 8.1e-39 ykoA
PFKLECOI_01435 5.8e-310 ybiT S COG0488 ATPase components of ABC transporters with duplicated ATPase domains
PFKLECOI_01436 2e-166 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PFKLECOI_01437 2e-238 ampS E COG2309 Leucyl aminopeptidase (aminopeptidase T)
PFKLECOI_01438 1.1e-12 S Uncharacterized protein YkpC
PFKLECOI_01439 7.7e-183 mreB D Rod-share determining protein MreBH
PFKLECOI_01440 1.5e-43 abrB K of stationary sporulation gene expression
PFKLECOI_01441 2.7e-241 kinC 2.7.13.3 T COG0642 Signal transduction histidine kinase
PFKLECOI_01442 1.4e-153 ykqA P Gamma-glutamyl cyclotransferase, AIG2-like
PFKLECOI_01443 4e-116 ktrA P COG0569 K transport systems, NAD-binding component
PFKLECOI_01444 0.0 ade 3.5.4.2 F Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
PFKLECOI_01445 0.0 rnjA S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
PFKLECOI_01446 8.2e-31 ykzG S Belongs to the UPF0356 family
PFKLECOI_01447 5.5e-147 ykrA S hydrolases of the HAD superfamily
PFKLECOI_01448 4e-101 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
PFKLECOI_01450 4.6e-109 recN L Putative cell-wall binding lipoprotein
PFKLECOI_01451 9.9e-192 pdhA 1.2.4.1, 1.2.4.4 C COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
PFKLECOI_01452 4.9e-179 pdhB 1.2.4.1 C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
PFKLECOI_01453 9.9e-231 pdhC 2.3.1.12 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
PFKLECOI_01454 2.4e-243 lpdA 1.8.1.4 C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
PFKLECOI_01455 1.3e-63 slp CO COG0526, thiol-disulfide isomerase and thioredoxins
PFKLECOI_01456 1e-276 speA 4.1.1.19 E Arginine
PFKLECOI_01457 1e-41 yktA S Belongs to the UPF0223 family
PFKLECOI_01458 2.1e-117 yktB S Belongs to the UPF0637 family
PFKLECOI_01459 7.1e-26 ykzI
PFKLECOI_01460 4.6e-151 suhB 3.1.3.25 G Inositol monophosphatase
PFKLECOI_01461 3.4e-77 ykzC S Acetyltransferase (GNAT) family
PFKLECOI_01462 9.3e-172 Q Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
PFKLECOI_01463 2.2e-293 mpl 3.4.24.28, 3.4.24.29 E Peptidase M4
PFKLECOI_01464 0.0 ylaA
PFKLECOI_01465 1.7e-17 ylaB
PFKLECOI_01466 5.2e-90 ylaC K Belongs to the sigma-70 factor family. ECF subfamily
PFKLECOI_01467 9.1e-12 sigC S Putative zinc-finger
PFKLECOI_01468 1.8e-38 ylaE
PFKLECOI_01469 4.1e-21 S Family of unknown function (DUF5325)
PFKLECOI_01470 0.0 typA T GTP-binding protein TypA
PFKLECOI_01471 4.2e-47 ylaH S YlaH-like protein
PFKLECOI_01472 2.5e-32 ylaI S protein conserved in bacteria
PFKLECOI_01473 1.1e-89 ylaJ S Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
PFKLECOI_01474 8e-249 phoH T ATPase related to phosphate starvation-inducible protein PhoH
PFKLECOI_01475 2.7e-85 ylaL S Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
PFKLECOI_01476 4.7e-171 glsA 3.5.1.2 E Belongs to the glutaminase family
PFKLECOI_01477 8.7e-44 ylaN S Belongs to the UPF0358 family
PFKLECOI_01478 7.9e-211 ftsW D Belongs to the SEDS family
PFKLECOI_01479 0.0 pyc 6.4.1.1 C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
PFKLECOI_01480 6.5e-165 ctaA 2.5.1.141 O Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group
PFKLECOI_01481 4.2e-164 ctaB 2.5.1.141 O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
PFKLECOI_01482 1.8e-190 ctaC 1.9.3.1 C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)
PFKLECOI_01483 0.0 ctaD 1.10.3.12, 1.9.3.1 C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PFKLECOI_01484 3.3e-112 cyoC 1.10.3.12, 1.9.3.1 C COG1845 Heme copper-type cytochrome quinol oxidase, subunit 3
PFKLECOI_01485 4.2e-53 ctaF 1.10.3.12, 1.9.3.1 C COG3125 Heme copper-type cytochrome quinol oxidase, subunit 4
PFKLECOI_01486 2.8e-165 ctaG S cytochrome c oxidase
PFKLECOI_01487 7e-62 ylbA S YugN-like family
PFKLECOI_01488 2.6e-74 ylbB T COG0517 FOG CBS domain
PFKLECOI_01489 9.6e-200 ylbC S protein with SCP PR1 domains
PFKLECOI_01490 4.1e-63 ylbD S Putative coat protein
PFKLECOI_01491 6.7e-37 ylbE S YlbE-like protein
PFKLECOI_01492 1.8e-75 ylbF S Belongs to the UPF0342 family
PFKLECOI_01493 3.7e-38 ylbG S UPF0298 protein
PFKLECOI_01494 1.6e-97 rsmD 2.1.1.171 L Methyltransferase
PFKLECOI_01495 3.9e-84 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PFKLECOI_01496 3.2e-220 ylbJ S Sporulation integral membrane protein YlbJ
PFKLECOI_01497 7.5e-138 ylbK S esterase of the alpha-beta hydrolase superfamily
PFKLECOI_01498 2.6e-186 ylbL T Belongs to the peptidase S16 family
PFKLECOI_01499 8.1e-235 ylbM S Belongs to the UPF0348 family
PFKLECOI_01501 3e-90 yceD S metal-binding, possibly nucleic acid-binding protein
PFKLECOI_01502 1.2e-27 rpmF J Belongs to the bacterial ribosomal protein bL32 family
PFKLECOI_01503 3.4e-74 ylbO S SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
PFKLECOI_01504 1.5e-88 ylbP K n-acetyltransferase
PFKLECOI_01505 1.5e-166 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PFKLECOI_01506 1.2e-307 bshC S Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
PFKLECOI_01507 2.9e-78 mraZ K Belongs to the MraZ family
PFKLECOI_01508 4.7e-171 rsmH 2.1.1.199 J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
PFKLECOI_01509 3.7e-44 ftsL D Essential cell division protein
PFKLECOI_01510 0.0 ftsI 3.4.16.4 M Penicillin-binding Protein
PFKLECOI_01511 0.0 ftsI 3.4.16.4 M stage V sporulation protein D
PFKLECOI_01512 5.2e-281 murE 6.3.2.10, 6.3.2.13 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PFKLECOI_01513 3.2e-170 mraY 2.7.8.13 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PFKLECOI_01514 2.6e-255 murD 6.3.2.9 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PFKLECOI_01515 5.7e-186 spoVE D Belongs to the SEDS family
PFKLECOI_01516 6.7e-201 murG 2.4.1.227, 6.3.2.8 GT28 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PFKLECOI_01517 4.5e-166 murB 1.3.1.98 M cell wall formation
PFKLECOI_01518 2.6e-138 divIB D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
PFKLECOI_01519 2.4e-103 ylxW S protein conserved in bacteria
PFKLECOI_01520 2.3e-102 ylxX S protein conserved in bacteria
PFKLECOI_01521 6.2e-58 sbp S small basic protein
PFKLECOI_01522 7e-229 ftsA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
PFKLECOI_01523 2.9e-202 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PFKLECOI_01524 0.0 bpr O COG1404 Subtilisin-like serine proteases
PFKLECOI_01525 2.2e-171 spoIIGA M aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR
PFKLECOI_01526 1.4e-125 sigE K sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PFKLECOI_01527 3.6e-140 sigG K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PFKLECOI_01528 2.4e-147 modF 3.6.3.21, 3.6.3.34 P COG1119 ABC-type molybdenum transport system, ATPase component photorepair protein PhrA
PFKLECOI_01529 6.8e-253 argE 3.5.1.16 E Acetylornithine deacetylase
PFKLECOI_01530 9e-37 ylmC S sporulation protein
PFKLECOI_01531 1.6e-157 yfiH S Belongs to the multicopper oxidase YfiH RL5 family
PFKLECOI_01532 6.5e-125 ylmE S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
PFKLECOI_01533 1.5e-61 sepF D Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
PFKLECOI_01534 1.3e-39 yggT S membrane
PFKLECOI_01535 2e-138 ylmH 5.4.99.23, 5.4.99.24 S conserved protein, contains S4-like domain
PFKLECOI_01536 2.6e-67 divIVA D Cell division initiation protein
PFKLECOI_01537 0.0 ileS 6.1.1.5 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PFKLECOI_01538 8.5e-63 dksA T COG1734 DnaK suppressor protein
PFKLECOI_01539 2e-77 lspA 3.4.23.36 MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PFKLECOI_01540 1.1e-164 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
PFKLECOI_01541 2.7e-94 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
PFKLECOI_01542 2.2e-230 pyrP F Xanthine uracil
PFKLECOI_01543 1.3e-165 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
PFKLECOI_01544 1.2e-249 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
PFKLECOI_01545 5e-212 carA 6.3.5.5 F Carbamoyl-phosphate synthetase glutamine chain
PFKLECOI_01546 0.0 carB 6.3.5.5 F Belongs to the CarB family
PFKLECOI_01547 1.4e-144 pyrK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )
PFKLECOI_01548 4.6e-174 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
PFKLECOI_01549 5.2e-125 pyrF 4.1.1.23 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
PFKLECOI_01550 1e-113 pyrE 2.4.2.10, 4.1.1.23 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PFKLECOI_01552 7.7e-142 cysH 1.8.4.10, 1.8.4.8, 2.7.1.25 EH Belongs to the PAPS reductase family. CysH subfamily
PFKLECOI_01553 1.4e-179 cysP P phosphate transporter
PFKLECOI_01554 1.3e-223 sat 2.7.7.4 P Belongs to the sulfate adenylyltransferase family
PFKLECOI_01555 7.3e-109 cysC 2.7.1.25 P Catalyzes the synthesis of activated sulfate
PFKLECOI_01556 2.2e-145 hemD 2.1.1.107, 4.2.1.75 H Belongs to the precorrin methyltransferase family
PFKLECOI_01557 1.4e-144 cbiX 4.99.1.3, 4.99.1.4, 5.4.99.60, 5.4.99.61 S Sirohydrochlorin ferrochelatase
PFKLECOI_01558 4.3e-83 cysG 1.3.1.76, 4.99.1.4 H Siroheme synthase
PFKLECOI_01559 0.0 FbpA K RNA-binding protein homologous to eukaryotic snRNP
PFKLECOI_01560 0.0 yloB 3.6.3.8 P COG0474 Cation transport ATPase
PFKLECOI_01561 3.1e-156 yloC S stress-induced protein
PFKLECOI_01562 1.5e-40 ylzA S Belongs to the UPF0296 family
PFKLECOI_01563 3.1e-110 gmk 2.7.4.8 F Essential for recycling GMP and indirectly, cGMP
PFKLECOI_01564 2.2e-28 rpoZ 2.7.7.6 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
PFKLECOI_01565 1.2e-222 coaBC 4.1.1.36, 6.3.2.5 H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PFKLECOI_01566 0.0 priA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PFKLECOI_01567 6.6e-84 def 2.1.2.9, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
PFKLECOI_01568 4e-173 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PFKLECOI_01569 1.2e-252 sun 2.1.1.176 J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PFKLECOI_01570 5.3e-206 rlmN 2.1.1.192 J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
PFKLECOI_01571 2.4e-141 stp 3.1.3.16 T phosphatase
PFKLECOI_01572 0.0 prkC 2.7.11.1 KLT serine threonine protein kinase
PFKLECOI_01573 1.9e-169 rsgA 3.1.3.100 S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
PFKLECOI_01574 2.1e-117 rpe 5.1.3.1 G Belongs to the ribulose-phosphate 3-epimerase family
PFKLECOI_01575 3.1e-121 thiN 2.7.6.2 H thiamine pyrophosphokinase
PFKLECOI_01576 4.2e-26 rpmB J Belongs to the bacterial ribosomal protein bL28 family
PFKLECOI_01577 5.5e-59 asp S protein conserved in bacteria
PFKLECOI_01578 2.1e-299 yloV S kinase related to dihydroxyacetone kinase
PFKLECOI_01579 1.9e-118 sdaAB 4.3.1.17 E L-serine dehydratase
PFKLECOI_01580 9.3e-156 sdaAA 4.3.1.17 E L-serine dehydratase
PFKLECOI_01581 0.0 recG 3.6.4.12 L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PFKLECOI_01582 4e-80 fapR 5.3.1.23 K Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism
PFKLECOI_01583 4.3e-178 plsX 2.3.1.15 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
PFKLECOI_01584 9.1e-170 fabD 2.3.1.39 I malonyl CoA-acyl carrier protein transacylase
PFKLECOI_01585 6.1e-129 IQ reductase
PFKLECOI_01586 2.8e-32 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
PFKLECOI_01587 1.2e-135 rnc 3.1.26.3 J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
PFKLECOI_01588 0.0 smc D Required for chromosome condensation and partitioning
PFKLECOI_01589 8.8e-176 ftsY U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
PFKLECOI_01590 1.1e-86
PFKLECOI_01591 1.6e-49 ylxM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
PFKLECOI_01592 3e-235 ffh 3.6.5.4 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PFKLECOI_01593 1.1e-43 rpsP J Belongs to the bacterial ribosomal protein bS16 family
PFKLECOI_01594 4.5e-36 ylqC S Belongs to the UPF0109 family
PFKLECOI_01595 1.4e-60 ylqD S YlqD protein
PFKLECOI_01596 5.3e-95 rimM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PFKLECOI_01597 2.1e-137 trmD 2.1.1.228, 4.6.1.12 J Belongs to the RNA methyltransferase TrmD family
PFKLECOI_01598 1.4e-56 rplS J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
PFKLECOI_01599 4.2e-158 ylqF S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
PFKLECOI_01600 6.9e-136 rnhB 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PFKLECOI_01601 7.2e-290 ylqG
PFKLECOI_01602 3e-44 ylqH S homolog of the cytoplasmic domain of flagellar protein FhlB
PFKLECOI_01603 3.4e-211 sucC 6.2.1.5 C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
PFKLECOI_01604 1.1e-167 sucD 6.2.1.5 C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PFKLECOI_01605 1.7e-170 dprA LU Rossmann fold nucleotide-binding protein involved in DNA uptake
PFKLECOI_01606 0.0 topA 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PFKLECOI_01607 2.2e-246 trmFO 2.1.1.74 J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
PFKLECOI_01608 2.5e-169 xerC L tyrosine recombinase XerC
PFKLECOI_01609 4.4e-92 hslV 3.4.25.2 O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
PFKLECOI_01610 1.5e-250 hslU O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
PFKLECOI_01611 9.2e-136 codY K DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
PFKLECOI_01612 2.3e-63 flgB N Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body
PFKLECOI_01613 6.9e-75 flgC N Belongs to the flagella basal body rod proteins family
PFKLECOI_01614 1.9e-31 fliE N Flagellar hook-basal body
PFKLECOI_01615 2.4e-255 fliF N The M ring may be actively involved in energy transduction
PFKLECOI_01616 2e-178 fliG N One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation
PFKLECOI_01617 2.5e-106 fliH NU COG1317 Flagellar biosynthesis type III secretory pathway protein
PFKLECOI_01618 2.1e-241 fliI 3.6.3.14 NU COG1157 Flagellar biosynthesis type III secretory pathway ATPase
PFKLECOI_01619 3.2e-69 fliJ N Flagellar biosynthesis chaperone
PFKLECOI_01620 1.3e-36 ylxF S MgtE intracellular N domain
PFKLECOI_01621 2e-216 fliK N Flagellar hook-length control protein
PFKLECOI_01622 1.7e-72 flgD N Flagellar basal body rod modification protein
PFKLECOI_01623 8.2e-140 flgG N Flagellar basal body rod
PFKLECOI_01624 4.6e-49 fliL N Controls the rotational direction of flagella during chemotaxis
PFKLECOI_01625 1.9e-181 fliM N One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation
PFKLECOI_01626 4.5e-184 fliN N FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PFKLECOI_01627 6.1e-58 cheB 3.1.1.61, 3.5.1.44 T response regulator
PFKLECOI_01628 9.3e-97 fliZ N Flagellar biosynthesis protein, FliO
PFKLECOI_01629 1.6e-109 fliP N Plays a role in the flagellum-specific transport system
PFKLECOI_01630 2.2e-36 fliQ N Role in flagellar biosynthesis
PFKLECOI_01631 3.6e-132 fliR N Flagellar biosynthetic protein FliR
PFKLECOI_01632 1.4e-190 flhB N Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PFKLECOI_01633 0.0 flhA N Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PFKLECOI_01634 5.7e-200 flhF N Flagellar biosynthesis regulator FlhF
PFKLECOI_01635 7.5e-158 flhG D Belongs to the ParA family
PFKLECOI_01636 5.8e-197 cheB 3.1.1.61, 3.5.1.44 NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR
PFKLECOI_01637 0.0 cheA 2.7.13.3 NT COG0643 Chemotaxis protein histidine kinase and related kinases
PFKLECOI_01638 2.8e-79 cheW NT COG0835 Chemotaxis signal transduction protein
PFKLECOI_01639 1.3e-111 cheC NT COG1776 Chemotaxis protein CheC, inhibitor of MCP methylation
PFKLECOI_01640 4.3e-86 cheD 3.5.1.44 NT Deamidates glutamine residues to glutamate on methyl- accepting chemotaxis receptors (MCPs). CheD-mediated MCP deamidation is required for productive communication of the conformational signals of the chemoreceptors to the CheA kinase
PFKLECOI_01641 5.6e-138 sigD K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PFKLECOI_01642 3.1e-76 ylxL
PFKLECOI_01643 1e-131 rpsB J Belongs to the universal ribosomal protein uS2 family
PFKLECOI_01644 5.3e-156 tsf J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PFKLECOI_01645 2.7e-126 pyrH 2.7.4.22 F Catalyzes the reversible phosphorylation of UMP to UDP
PFKLECOI_01646 6.4e-91 frr J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
PFKLECOI_01647 8.3e-145 uppS 2.5.1.31 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PFKLECOI_01648 1.6e-138 cdsA 2.7.7.41 S Belongs to the CDS family
PFKLECOI_01649 4.6e-216 dxr 1.1.1.267 I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
PFKLECOI_01650 7.7e-233 rasP M zinc metalloprotease
PFKLECOI_01651 0.0 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
PFKLECOI_01652 0.0 polC 2.7.7.7 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PFKLECOI_01653 3.3e-80 rimP S Required for maturation of 30S ribosomal subunits
PFKLECOI_01654 1.1e-203 nusA K Participates in both transcription termination and antitermination
PFKLECOI_01655 3.4e-32 ylxR K nucleic-acid-binding protein implicated in transcription termination
PFKLECOI_01656 3.1e-47 ylxQ J ribosomal protein
PFKLECOI_01657 0.0 infB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PFKLECOI_01658 3e-44 ylxP S protein conserved in bacteria
PFKLECOI_01659 5e-57 rbfA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PFKLECOI_01660 1.5e-172 truB 5.4.99.25 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PFKLECOI_01661 1.5e-180 ribF 2.7.1.26, 2.7.7.2 H Belongs to the ribF family
PFKLECOI_01662 6e-42 rpsO J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PFKLECOI_01663 0.0 pnp 2.7.7.8 J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
PFKLECOI_01664 1.2e-180 ylxY 3.5.1.104 G Sporulation protein, polysaccharide deacetylase
PFKLECOI_01665 4.4e-233 pepR S Belongs to the peptidase M16 family
PFKLECOI_01666 2.6e-42 ymxH S YlmC YmxH family
PFKLECOI_01667 2.9e-162 spoVFA 1.1.1.29, 1.1.1.399, 1.1.1.95 CH Dipicolinate synthase subunit A
PFKLECOI_01668 4.3e-109 spoVFB H Together with DpaA, catalyzes the conversion of dihydrodipicolinate to dipicolinate (DPA)
PFKLECOI_01669 1.4e-192 asd 1.2.1.11 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PFKLECOI_01670 1.7e-221 dapG 1.1.1.3, 2.7.2.4 E Belongs to the aspartokinase family
PFKLECOI_01671 1.4e-156 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PFKLECOI_01672 1.9e-308 rnjB S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
PFKLECOI_01673 5.3e-133 tepA 3.4.21.92 OU COG0740 Protease subunit of ATP-dependent Clp proteases
PFKLECOI_01674 4.4e-32 S YlzJ-like protein
PFKLECOI_01675 0.0 ftsK D Belongs to the FtsK SpoIIIE SftA family
PFKLECOI_01676 1.4e-133 ymfC K Transcriptional regulator
PFKLECOI_01677 3.8e-205 ymfD EGP Major facilitator Superfamily
PFKLECOI_01678 1.2e-233 ymfF S Peptidase M16
PFKLECOI_01679 1.4e-242 ymfH S zinc protease
PFKLECOI_01680 9.2e-130 ymfI 1.1.1.100, 1.3.1.28 S Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
PFKLECOI_01681 4.8e-41 ymfJ S Protein of unknown function (DUF3243)
PFKLECOI_01682 3.5e-143 ymfK S Protein of unknown function (DUF3388)
PFKLECOI_01683 1.9e-124 ymfM S protein conserved in bacteria
PFKLECOI_01684 2.5e-101 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PFKLECOI_01685 1.9e-236 cinA 3.5.1.42 S Belongs to the CinA family
PFKLECOI_01686 8.1e-188 recA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PFKLECOI_01687 1e-215 pbpX V Beta-lactamase
PFKLECOI_01688 2.1e-224 rny S Endoribonuclease that initiates mRNA decay
PFKLECOI_01689 1.9e-152 ymdB S protein conserved in bacteria
PFKLECOI_01690 1.2e-36 spoVS S Stage V sporulation protein S
PFKLECOI_01691 1.9e-197 tdh 1.1.1.103 C Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate
PFKLECOI_01692 4.2e-217 kbl 2.3.1.29, 2.3.1.47 H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide
PFKLECOI_01693 2.7e-296 miaB 2.8.4.3 J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PFKLECOI_01694 9.2e-69 ymcA 3.6.3.21 S Belongs to the UPF0342 family
PFKLECOI_01695 2.2e-88 cotE S Spore coat protein
PFKLECOI_01696 0.0 mutS L that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PFKLECOI_01697 0.0 mutL L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PFKLECOI_01698 8.9e-70 S Regulatory protein YrvL
PFKLECOI_01699 1.2e-97 ymcC S Membrane
PFKLECOI_01700 2.9e-108 pksA K Transcriptional regulator
PFKLECOI_01701 2.5e-129 pksB 3.1.2.6 S Polyketide biosynthesis
PFKLECOI_01703 2.2e-162 fabD 2.3.1.39 I malonyl CoA-acyl carrier protein transacylase
PFKLECOI_01705 6e-185 pksD Q Acyl transferase domain
PFKLECOI_01706 0.0 fabD 1.13.12.16, 2.3.1.39 I malonyl CoA-acyl carrier protein transacylase
PFKLECOI_01707 1.4e-37 acpK IQ Phosphopantetheine attachment site
PFKLECOI_01708 8.7e-237 pksF 2.3.1.179, 2.3.1.41 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
PFKLECOI_01709 1.5e-244 pksG 2.3.3.10 I synthase
PFKLECOI_01710 5.9e-143 pksH 4.2.1.18 I enoyl-CoA hydratase
PFKLECOI_01711 5.7e-135 pksI I Belongs to the enoyl-CoA hydratase isomerase family
PFKLECOI_01712 0.0 rhiB IQ polyketide synthase
PFKLECOI_01713 0.0 pfaA Q Polyketide synthase of type I
PFKLECOI_01714 0.0 pfaA 4.1.1.35 GT4 IQ polyketide synthase
PFKLECOI_01715 0.0 dhbF IQ polyketide synthase
PFKLECOI_01716 0.0 pks13 HQ Beta-ketoacyl synthase
PFKLECOI_01717 3.1e-231 cypA C Cytochrome P450
PFKLECOI_01718 4.4e-61 ymzB
PFKLECOI_01719 8.1e-162 ymaE S Metallo-beta-lactamase superfamily
PFKLECOI_01720 1.1e-250 aprX O Belongs to the peptidase S8 family
PFKLECOI_01721 1.9e-07 K Transcriptional regulator
PFKLECOI_01722 2.1e-126 ymaC S Replication protein
PFKLECOI_01723 5.4e-80 ymaD O redox protein, regulator of disulfide bond formation
PFKLECOI_01724 8.1e-55 ebrB P COG2076 Membrane transporters of cations and cationic drugs
PFKLECOI_01725 4.9e-51 ebrA P Small Multidrug Resistance protein
PFKLECOI_01727 2.1e-46 ymaF S YmaF family
PFKLECOI_01728 2.1e-174 miaA 2.5.1.75 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PFKLECOI_01729 1.9e-33 hfq J RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs
PFKLECOI_01730 8.2e-23
PFKLECOI_01731 4.5e-22 ymzA
PFKLECOI_01732 1.9e-49 nrdI 1.17.4.1 F Probably involved in ribonucleotide reductase function
PFKLECOI_01733 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PFKLECOI_01734 4.5e-188 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PFKLECOI_01735 2e-109 ymaB
PFKLECOI_01736 8.8e-115 cwlC 3.5.1.28 M n-acetylmuramoyl-L-alanine amidase
PFKLECOI_01737 8.6e-176 spoVK O stage V sporulation protein K
PFKLECOI_01738 7.9e-230 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PFKLECOI_01739 7.4e-244 ynbB 4.4.1.1 P COG4100 Cystathionine beta-lyase family protein involved in aluminum resistance
PFKLECOI_01740 1.1e-68 glnR K transcriptional
PFKLECOI_01741 7e-261 glnA 6.3.1.2 E glutamine synthetase
PFKLECOI_01742 1.5e-60 L Belongs to the 'phage' integrase family
PFKLECOI_01743 1.1e-94 3.1.4.46, 5.4.2.11 C glycerophosphoryl diester phosphodiesterase
PFKLECOI_01744 6e-57 S Bacteriophage holin family
PFKLECOI_01745 4.4e-37 xlyA 3.5.1.28 CBM50 M N-acetylmuramoyl-L-alanine amidase
PFKLECOI_01746 1.3e-160 M COG0463 Glycosyltransferases involved in cell wall biogenesis
PFKLECOI_01747 6.4e-217 sumf2 2.1.1.295 GT2,GT4 H N-terminal domain of galactosyltransferase
PFKLECOI_01749 2.9e-96 ynaD J Acetyltransferase (GNAT) domain
PFKLECOI_01751 2.6e-73 S CAAX protease self-immunity
PFKLECOI_01752 1e-07 ywlA S Uncharacterised protein family (UPF0715)
PFKLECOI_01753 1.5e-22 K Cro/C1-type HTH DNA-binding domain
PFKLECOI_01754 5.4e-110 ynaE S Domain of unknown function (DUF3885)
PFKLECOI_01757 3.2e-80 XK27_05370 5.3.1.24 E phosphoribosylanthranilate isomerase activity
PFKLECOI_01758 7.4e-253 xynT G MFS/sugar transport protein
PFKLECOI_01759 0.0 xynB 3.2.1.37 GH43 G Belongs to the glycosyl hydrolase 43 family
PFKLECOI_01760 7.3e-214 xylR GK ROK family
PFKLECOI_01761 2.4e-261 xylA 5.3.1.5 G Belongs to the xylose isomerase family
PFKLECOI_01762 2.1e-290 xylB 2.7.1.12, 2.7.1.17, 2.7.1.5 G xylulose kinase
PFKLECOI_01763 3.7e-111 yokF 3.1.31.1 L RNA catabolic process
PFKLECOI_01764 1e-254 iolT EGP Major facilitator Superfamily
PFKLECOI_01765 1e-218 alr 5.1.1.1 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PFKLECOI_01766 2e-82 yncE S Protein of unknown function (DUF2691)
PFKLECOI_01767 4.9e-78 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F Deoxyuridine 5'-triphosphate
PFKLECOI_01768 5.2e-15
PFKLECOI_01771 8.6e-164 S Thymidylate synthase
PFKLECOI_01773 3.2e-133 S Domain of unknown function, YrpD
PFKLECOI_01776 7.9e-25 tatA U protein secretion
PFKLECOI_01777 4.1e-71
PFKLECOI_01778 5.2e-80 yndB S Activator of Hsp90 ATPase homolog 1-like protein
PFKLECOI_01781 9.3e-281 gerAA EG Spore germination protein
PFKLECOI_01782 5e-196 gerAB U Spore germination
PFKLECOI_01783 2.3e-218 gerLC S Spore germination protein
PFKLECOI_01784 1.1e-152 yndG S DoxX-like family
PFKLECOI_01785 3.2e-115 yndH S Domain of unknown function (DUF4166)
PFKLECOI_01786 4.5e-310 yndJ S YndJ-like protein
PFKLECOI_01788 4.7e-137 yndL S Replication protein
PFKLECOI_01789 5.8e-74 yndM S Protein of unknown function (DUF2512)
PFKLECOI_01790 2e-79 fosB 2.5.1.18 H Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor
PFKLECOI_01791 2.6e-109 lexA 3.4.21.88 K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PFKLECOI_01792 9.9e-49 yneA D Inhibits cell division during the SOS response. Affects a later stage of the cell division protein assembly, after the assembly of the Z ring, by probably suppressing recruitment of FtsL and or DivIC to the division machinery
PFKLECOI_01793 4.5e-112 yneB L resolvase
PFKLECOI_01794 1.3e-32 ynzC S UPF0291 protein
PFKLECOI_01795 0.0 tkt 2.2.1.1 G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PFKLECOI_01796 2.2e-81 yneE S Sporulation inhibitor of replication protein sirA
PFKLECOI_01797 1.8e-28 yneF S UPF0154 protein
PFKLECOI_01798 7.5e-14 ynzD S Spo0E like sporulation regulatory protein
PFKLECOI_01799 7.1e-127 ccdA O cytochrome c biogenesis protein
PFKLECOI_01800 7.2e-59 cheB 3.1.1.61, 3.5.1.44 T cheY-homologous receiver domain
PFKLECOI_01801 5.1e-76 yneJ O COG4846 Membrane protein involved in cytochrome C biogenesis
PFKLECOI_01802 2.1e-73 yneK S Protein of unknown function (DUF2621)
PFKLECOI_01803 1.1e-62 hspX O Spore coat protein
PFKLECOI_01804 3.9e-19 sspP S Belongs to the SspP family
PFKLECOI_01805 2.2e-14 sspO S Belongs to the SspO family
PFKLECOI_01806 0.0 acnA 4.2.1.3 C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
PFKLECOI_01807 1e-90 yneN CO alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PFKLECOI_01809 3.1e-08 sspN S Small acid-soluble spore protein N family
PFKLECOI_01810 3.9e-35 tlp S Belongs to the Tlp family
PFKLECOI_01811 1.2e-73 yneP S Thioesterase-like superfamily
PFKLECOI_01812 2.9e-53 yneQ
PFKLECOI_01813 4.1e-49 yneR S Belongs to the HesB IscA family
PFKLECOI_01814 5e-94 plsY 2.3.1.15, 3.5.1.104 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
PFKLECOI_01815 6.6e-69 yccU S CoA-binding protein
PFKLECOI_01816 0.0 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
PFKLECOI_01817 0.0 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
PFKLECOI_01818 2.3e-12
PFKLECOI_01819 8.6e-57 ynfC
PFKLECOI_01820 8.2e-252 agcS E Sodium alanine symporter
PFKLECOI_01821 2e-296 bglC5 3.2.1.4 GH5,GH9 G PFAM glycoside hydrolase family 5
PFKLECOI_01823 1.8e-250 xynC 3.2.1.136 GH5 M Belongs to the glycosyl hydrolase 30 family
PFKLECOI_01824 3e-295 xynD3 3.2.1.55 CBM6,GH43 G Belongs to the glycosyl hydrolase 43 family
PFKLECOI_01825 2.4e-80 yngA S membrane
PFKLECOI_01826 5.9e-163 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
PFKLECOI_01827 5.5e-104 yngC S membrane-associated protein
PFKLECOI_01828 9.5e-233 nrnB S phosphohydrolase (DHH superfamily)
PFKLECOI_01829 1.7e-287 yngE 2.1.3.15, 6.4.1.3 I COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
PFKLECOI_01830 3.2e-136 yngF 4.2.1.17 I Belongs to the enoyl-CoA hydratase isomerase family
PFKLECOI_01831 2.3e-167 mvaB 4.1.3.4, 6.4.1.4 E Hydroxymethylglutaryl-CoA lyase
PFKLECOI_01832 6e-32 pycB 2.3.1.12, 6.4.1.1 I Biotin carboxyl carrier protein
PFKLECOI_01833 1.7e-246 yngH 6.3.4.14, 6.4.1.2, 6.4.1.3, 6.4.1.4 I Biotin carboxylase
PFKLECOI_01834 0.0 yngI IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
PFKLECOI_01835 5.4e-209 yngJ 1.3.8.1, 1.3.99.12 I acyl-CoA dehydrogenase
PFKLECOI_01837 5.9e-304 yngK T Glycosyl hydrolase-like 10
PFKLECOI_01838 1.1e-63 yngL S Protein of unknown function (DUF1360)
PFKLECOI_01839 0.0 6.3.2.14 Q amino acid activation for nonribosomal peptide biosynthetic process
PFKLECOI_01840 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
PFKLECOI_01841 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
PFKLECOI_01842 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
PFKLECOI_01843 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
PFKLECOI_01844 1.1e-74 nucB M Deoxyribonuclease NucA/NucB
PFKLECOI_01845 2.3e-133 yqeB
PFKLECOI_01846 5.9e-171 gnd 1.1.1.343, 1.1.1.44 G 6-phosphogluconate dehydrogenase
PFKLECOI_01847 1.2e-104 yqeD S SNARE associated Golgi protein
PFKLECOI_01848 2e-132 xlyA 3.5.1.28 M n-acetylmuramoyl-L-alanine amidase
PFKLECOI_01849 1.8e-141 yqeF E GDSL-like Lipase/Acylhydrolase
PFKLECOI_01851 5.3e-95 yqeG S hydrolase of the HAD superfamily
PFKLECOI_01852 9.1e-214 yqeH S In Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis
PFKLECOI_01853 3.9e-156 aroE 1.1.1.25 E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PFKLECOI_01854 2.1e-45 yhbY J RNA-binding protein containing KH domain, possibly ribosomal protein
PFKLECOI_01855 2.7e-108 nadD 2.7.7.18, 3.6.1.55 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PFKLECOI_01856 6.2e-102 nadD 2.7.6.3, 2.7.7.18 H HD superfamily hydrolase involved in NAD metabolism
PFKLECOI_01857 3.4e-61 rsfS J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
PFKLECOI_01858 3.2e-138 yqeM Q Methyltransferase
PFKLECOI_01859 2.5e-147 comER E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PFKLECOI_01860 2.5e-104 wza L COG1555 DNA uptake protein and related DNA-binding proteins
PFKLECOI_01861 2.1e-105 comEB 3.5.4.12 F ComE operon protein 2
PFKLECOI_01862 0.0 comEC S Competence protein ComEC
PFKLECOI_01863 4.1e-15 S YqzM-like protein
PFKLECOI_01864 9.6e-189 holA 2.7.7.7 L DNA polymerase III delta subunit
PFKLECOI_01865 9.7e-37 rpsT J Binds directly to 16S ribosomal RNA
PFKLECOI_01866 1.3e-204 gpr 3.4.24.78 C Initiates the rapid degradation of small, acid-soluble proteins during spore germination
PFKLECOI_01867 2.6e-222 spoIIP M stage II sporulation protein P
PFKLECOI_01868 7.2e-53 yqxA S Protein of unknown function (DUF3679)
PFKLECOI_01869 0.0 lepA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
PFKLECOI_01870 2.6e-216 hemN H Involved in the biosynthesis of porphyrin-containing compound
PFKLECOI_01871 4.7e-188 hrcA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
PFKLECOI_01872 1.6e-65 grpE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PFKLECOI_01873 0.0 dnaK O Heat shock 70 kDa protein
PFKLECOI_01874 4.2e-182 dnaJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
PFKLECOI_01875 4.6e-174 prmA J Methylates ribosomal protein L11
PFKLECOI_01876 3.6e-140 rsmE 2.1.1.193 J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
PFKLECOI_01877 2.1e-260 yqeV 2.8.4.5 J ribosomal protein S12 methylthiotransferase
PFKLECOI_01878 1.4e-157 yqeW P COG1283 Na phosphate symporter
PFKLECOI_01879 1.2e-19 rpsU J Belongs to the bacterial ribosomal protein bS21 family
PFKLECOI_01880 2.5e-61 yqeY S Yqey-like protein
PFKLECOI_01881 4.5e-228 yqeZ O COG1030 Membrane-bound serine protease (ClpP class)
PFKLECOI_01882 3.7e-121 yqfA S UPF0365 protein
PFKLECOI_01883 1e-24 yqfB
PFKLECOI_01884 2.7e-45 yqfC S sporulation protein YqfC
PFKLECOI_01885 2.8e-184 yqfD 3.1.3.102, 3.1.3.104 S Stage IV sporulation
PFKLECOI_01886 1.1e-175 phoH T Phosphate starvation-inducible protein PhoH
PFKLECOI_01888 0.0 yqfF S membrane-associated HD superfamily hydrolase
PFKLECOI_01889 5.1e-81 ybeY 2.6.99.2, 3.5.4.5 S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PFKLECOI_01890 1.8e-60 dgkA 2.7.1.107, 2.7.1.66 M Diacylglycerol kinase
PFKLECOI_01891 7.1e-71 cdd 2.4.2.2, 3.5.4.5 F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
PFKLECOI_01892 3.1e-167 era S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PFKLECOI_01893 8.4e-19 S YqzL-like protein
PFKLECOI_01894 6.3e-145 recO L Involved in DNA repair and RecF pathway recombination
PFKLECOI_01895 3.3e-174 glyQ 6.1.1.14 J glycyl-tRNA synthetase alpha subunit
PFKLECOI_01896 0.0 glyS 6.1.1.14 J Glycyl-tRNA synthetase beta subunit
PFKLECOI_01897 4.5e-112 ccpN K CBS domain
PFKLECOI_01898 5.8e-149 yqfL 2.7.11.33, 2.7.4.28 S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation
PFKLECOI_01899 4.5e-88 yaiI S Belongs to the UPF0178 family
PFKLECOI_01900 0.0 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
PFKLECOI_01901 1.2e-200 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
PFKLECOI_01902 1.6e-61 cccA C COG2010 Cytochrome c, mono- and diheme variants
PFKLECOI_01903 2.6e-115 trmK 2.1.1.217 S SAM-dependent methyltransferase
PFKLECOI_01904 5.6e-211 yqfO 3.5.4.16 S Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PFKLECOI_01905 4.9e-176 ispH 1.17.7.4, 2.7.4.25 IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PFKLECOI_01906 2.9e-14 yqfQ S YqfQ-like protein
PFKLECOI_01907 1.7e-243 cshB 3.6.4.13 JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
PFKLECOI_01908 3.4e-166 nfo 3.1.21.2 L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
PFKLECOI_01909 2.1e-36 yqfT S Protein of unknown function (DUF2624)
PFKLECOI_01910 1.6e-157 yqfU S Uncharacterized protein conserved in bacteria (DUF2179)
PFKLECOI_01911 1.9e-77 zur P Belongs to the Fur family
PFKLECOI_01912 1.2e-108 yqfW S Belongs to the 5'(3')-deoxyribonucleotidase family
PFKLECOI_01913 4.3e-62 yqfX S membrane
PFKLECOI_01914 2.8e-202 ispG 1.17.7.1, 1.17.7.3 I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PFKLECOI_01915 1.5e-46 yqfZ M LysM domain
PFKLECOI_01916 3.9e-131 yqgB S Protein of unknown function (DUF1189)
PFKLECOI_01917 4e-73 yqgC S protein conserved in bacteria
PFKLECOI_01918 6.3e-116 sodA 1.15.1.1 P radicals which are normally produced within the cells and which are toxic to biological systems
PFKLECOI_01919 2.5e-231 yqgE EGP Major facilitator superfamily
PFKLECOI_01920 0.0 pbpA 3.4.16.4 M penicillin-binding protein
PFKLECOI_01921 1.7e-149 pstS P Phosphate
PFKLECOI_01922 3.2e-159 pstC P probably responsible for the translocation of the substrate across the membrane
PFKLECOI_01923 2.2e-157 pstA P Phosphate transport system permease
PFKLECOI_01924 1.4e-147 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
PFKLECOI_01925 3.7e-145 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
PFKLECOI_01926 7.3e-72 yqzC S YceG-like family
PFKLECOI_01927 3.5e-50 yqzD
PFKLECOI_01929 2.7e-202 yqgM 2.4.1.11, 2.4.1.18 GH57,GT4 M Glycosyl transferases group 1
PFKLECOI_01930 9.4e-21 rpmG J Belongs to the bacterial ribosomal protein bL33 family
PFKLECOI_01931 1.3e-102 ygfA 6.3.3.2 H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PFKLECOI_01932 2.5e-09 yqgO
PFKLECOI_01933 6.4e-266 gluP 3.4.21.105 O membrane protein (homolog of Drosophila rhomboid)
PFKLECOI_01934 4.7e-32 yqgQ S Protein conserved in bacteria
PFKLECOI_01935 5.8e-180 glcK 2.7.1.2 G Glucokinase
PFKLECOI_01936 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
PFKLECOI_01937 9.3e-222 yqgT 3.4.19.11 E Gamma-D-glutamyl-L-diamino acid endopeptidase
PFKLECOI_01938 7.4e-197 yqgU
PFKLECOI_01939 6.9e-50 yqgV S Thiamine-binding protein
PFKLECOI_01940 8.9e-23 yqgW S Protein of unknown function (DUF2759)
PFKLECOI_01941 2.1e-122 ycbL 3.1.2.6 S COG0491 Zn-dependent hydrolases, including glyoxylases
PFKLECOI_01942 1.8e-37 yqgY S Protein of unknown function (DUF2626)
PFKLECOI_01943 2.3e-63 yqgZ 1.20.4.1 P Belongs to the ArsC family
PFKLECOI_01945 1.2e-149 yqhA T COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
PFKLECOI_01946 9.8e-239 corC1 S COG1253 Hemolysins and related proteins containing CBS domains
PFKLECOI_01947 4e-173 corA P Mg2 transporter protein
PFKLECOI_01949 3.9e-201 comGA NU COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PFKLECOI_01950 5.1e-174 comGB NU COG1459 Type II secretory pathway, component PulF
PFKLECOI_01951 1.4e-47 comGC U Required for transformation and DNA binding
PFKLECOI_01952 2.2e-70 gspH NU protein transport across the cell outer membrane
PFKLECOI_01953 1.3e-57 comGE
PFKLECOI_01954 2.7e-45 comGF U Putative Competence protein ComGF
PFKLECOI_01955 3.4e-43 S ComG operon protein 7
PFKLECOI_01956 5.2e-26 yqzE S YqzE-like protein
PFKLECOI_01957 1.1e-52 yqzG S Protein of unknown function (DUF3889)
PFKLECOI_01958 1.4e-112 yqxM
PFKLECOI_01959 2.5e-58 sipW 3.4.21.89 U Signal peptidase
PFKLECOI_01960 1.9e-141 tasA S Cell division protein FtsN
PFKLECOI_01961 1e-54 sinR K transcriptional
PFKLECOI_01962 2.1e-24 sinI S Anti-repressor SinI
PFKLECOI_01963 1.5e-149 yqhG S Bacterial protein YqhG of unknown function
PFKLECOI_01964 0.0 yqhH L COG0553 Superfamily II DNA RNA helicases, SNF2 family
PFKLECOI_01965 2.4e-206 gcvT 1.4.4.2, 2.1.2.10 E The glycine cleavage system catalyzes the degradation of glycine
PFKLECOI_01966 1.7e-254 gcvPA 1.4.4.2 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PFKLECOI_01967 3.7e-287 gcvPB 1.4.4.2 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PFKLECOI_01968 2.3e-63 yqhL P COG0607 Rhodanese-related sulfurtransferase
PFKLECOI_01969 2.6e-160 lipM 6.3.1.20 H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation
PFKLECOI_01970 9.4e-74 mntR K Involved in manganese homeostasis. Might activate the transcription of the mntABCD operon
PFKLECOI_01971 4e-164 yqhO S esterase of the alpha-beta hydrolase superfamily
PFKLECOI_01972 2.2e-61 yqhP
PFKLECOI_01973 8e-174 yqhQ S Protein of unknown function (DUF1385)
PFKLECOI_01974 2.3e-93 yqhR S Conserved membrane protein YqhR
PFKLECOI_01975 1.5e-77 aroQ 4.2.1.10 E Catalyzes a trans-dehydration via an enolate intermediate
PFKLECOI_01976 3.4e-173 yqhT 3.4.11.9, 3.4.13.9 E COG0006 Xaa-Pro aminopeptidase
PFKLECOI_01977 5.4e-98 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PFKLECOI_01978 7.9e-37 yqhV S Protein of unknown function (DUF2619)
PFKLECOI_01979 1e-170 spoIIIAA S stage III sporulation protein AA
PFKLECOI_01980 1.1e-84 spoIIIAB S Stage III sporulation protein
PFKLECOI_01981 7.6e-29 spoIIIAC S stage III sporulation protein AC
PFKLECOI_01982 2.3e-58 spoIIIAD S Stage III sporulation protein AD
PFKLECOI_01983 8.4e-197 spoIIIAE S stage III sporulation protein AE
PFKLECOI_01984 4.1e-102 spoIIIAF S Stage III sporulation protein AF (Spore_III_AF)
PFKLECOI_01985 8.5e-109 spoIIIAG S stage III sporulation protein AG
PFKLECOI_01986 9.9e-91 spoIIIAH S SpoIIIAH-like protein
PFKLECOI_01987 1.5e-64 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
PFKLECOI_01988 5.9e-255 accC 6.3.4.14, 6.4.1.2 I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
PFKLECOI_01989 2.1e-67 yqhY S protein conserved in bacteria
PFKLECOI_01990 1.9e-65 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PFKLECOI_01991 1e-156 folD 1.5.1.5, 3.5.4.9 F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PFKLECOI_01992 2.9e-246 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
PFKLECOI_01993 5.8e-39 xseB 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
PFKLECOI_01994 2.9e-162 ispA 2.5.1.1, 2.5.1.10, 2.5.1.29, 2.5.1.90 H Belongs to the FPP GGPP synthase family
PFKLECOI_01995 0.0 dxs 2.2.1.7 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PFKLECOI_01996 1.9e-155 rrmJ 2.1.1.226, 2.1.1.227 J rRNA methylase
PFKLECOI_01997 3.9e-78 argR K Regulates arginine biosynthesis genes
PFKLECOI_01998 6.5e-307 recN L May be involved in recombinational repair of damaged DNA
PFKLECOI_01999 1.2e-238 rseP 3.4.21.116 M Stage IV sporulation protein B
PFKLECOI_02000 3.2e-144 KT May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process
PFKLECOI_02002 1.3e-215 yqiG C COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family
PFKLECOI_02003 2.3e-26
PFKLECOI_02004 1.7e-105 amiC 3.5.1.28 M Cell wall hydrolase autolysin
PFKLECOI_02005 3.1e-133 yqiK 3.1.4.46 C glycerophosphoryl diester phosphodiesterase
PFKLECOI_02006 1.2e-219 mmgA 2.3.1.9 I Belongs to the thiolase family
PFKLECOI_02007 1e-156 hbdA 1.1.1.157 I Dehydrogenase
PFKLECOI_02008 1.5e-211 mmgC I acyl-CoA dehydrogenase
PFKLECOI_02009 7.6e-208 prpC 2.3.3.1, 2.3.3.5 C Belongs to the citrate synthase family
PFKLECOI_02010 5.3e-275 prpD 4.2.1.79 S 2-methylcitrate dehydratase
PFKLECOI_02011 3e-162 prpB 4.1.3.30 G Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
PFKLECOI_02012 4e-34 yqzF S Protein of unknown function (DUF2627)
PFKLECOI_02013 0.0 bkdR 2.7.13.3 KT Transcriptional regulator
PFKLECOI_02014 1e-154 pta 2.3.1.19, 2.3.1.8 C phosphate butyryltransferase
PFKLECOI_02015 2.2e-207 ldh 1.4.1.9 E Belongs to the Glu Leu Phe Val dehydrogenases family
PFKLECOI_02016 2.7e-202 buk 2.7.2.7 C Belongs to the acetokinase family
PFKLECOI_02017 9.8e-269 lpdA 1.8.1.4 C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
PFKLECOI_02018 7.2e-186 bfmBAA 1.2.4.4 C COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
PFKLECOI_02019 1.8e-184 bfmBAB 1.2.4.1, 1.2.4.4 C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
PFKLECOI_02020 5.9e-225 bfmBB 2.3.1.168, 2.3.1.61 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
PFKLECOI_02021 1.4e-150 bmrR K helix_turn_helix, mercury resistance
PFKLECOI_02022 7.9e-208 norA EGP Major facilitator Superfamily
PFKLECOI_02023 3.4e-166 yegS 2.7.1.107 I COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
PFKLECOI_02024 9.3e-77 yqiW S Belongs to the UPF0403 family
PFKLECOI_02025 1.2e-135 artP ET Belongs to the bacterial solute-binding protein 3 family
PFKLECOI_02026 3.1e-108 artQ E COG0765 ABC-type amino acid transport system, permease component
PFKLECOI_02027 2e-129 artM 3.6.3.21 E COG1126 ABC-type polar amino acid transport system, ATPase component
PFKLECOI_02028 7.3e-175 yqjA S Putative aromatic acid exporter C-terminal domain
PFKLECOI_02029 5.2e-98 yqjB S protein conserved in bacteria
PFKLECOI_02031 2.5e-71 mce 4.4.1.5, 5.1.99.1, 5.4.99.2 E COG0346 Lactoylglutathione lyase and related lyases
PFKLECOI_02032 3.5e-288 mmdA 2.1.3.15, 6.4.1.3 I COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
PFKLECOI_02033 1.4e-201 yqjE 3.4.11.4 E COG2195 Di- and tripeptidases
PFKLECOI_02034 3.6e-142 yqjF S Uncharacterized conserved protein (COG2071)
PFKLECOI_02035 5.7e-144 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
PFKLECOI_02036 4.5e-24 yqzJ
PFKLECOI_02037 7.3e-236 dinB 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PFKLECOI_02038 6.9e-267 gnd 1.1.1.343, 1.1.1.44 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
PFKLECOI_02039 5.2e-289 zwf 1.1.1.363, 1.1.1.49 G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PFKLECOI_02040 2.9e-173 rnz 3.1.26.11 S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
PFKLECOI_02041 3e-19 rpmG J Belongs to the bacterial ribosomal protein bL33 family
PFKLECOI_02042 1.4e-144 yqjL S hydrolases or acyltransferases (alpha beta hydrolase superfamily)
PFKLECOI_02043 1.4e-192 namA 1.6.99.1 C Catalyzes the reduction of the double bond of an array of alpha,beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes
PFKLECOI_02044 0.0 rocB E arginine degradation protein
PFKLECOI_02045 5.6e-147 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PFKLECOI_02046 1e-176 yqjP S COG0491 Zn-dependent hydrolases, including glyoxylases
PFKLECOI_02047 4.6e-143 yqjQ S Belongs to the short-chain dehydrogenases reductases (SDR) family
PFKLECOI_02048 9e-264 dsdA 4.3.1.18 E Belongs to the serine threonine dehydratase family. DsdA subfamily
PFKLECOI_02049 2.4e-178 coaA 2.7.1.33 F Pantothenic acid kinase
PFKLECOI_02050 7.9e-72 yqjT 3.1.26.4 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PFKLECOI_02052 2e-225 yqjV G Major Facilitator Superfamily
PFKLECOI_02054 2e-238 polYB 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PFKLECOI_02055 5.7e-50 S YolD-like protein
PFKLECOI_02056 3.6e-87 yqjY K acetyltransferase
PFKLECOI_02057 7.5e-58 yqjZ 2.3.1.128, 2.5.1.18 S enzyme involved in biosynthesis of extracellular polysaccharides
PFKLECOI_02058 3.7e-193 yqkA K GrpB protein
PFKLECOI_02059 2.8e-54 yqkB S Belongs to the HesB IscA family
PFKLECOI_02060 9.4e-39 yqkC S Protein of unknown function (DUF2552)
PFKLECOI_02061 8.5e-173 yqkD S COG1073 Hydrolases of the alpha beta superfamily
PFKLECOI_02062 6.5e-10 yqkE S Protein of unknown function (DUF3886)
PFKLECOI_02063 6.3e-168 yqkF C oxidoreductases (related to aryl-alcohol dehydrogenases)
PFKLECOI_02065 4.5e-92 nudF 3.6.1.13 L Belongs to the Nudix hydrolase family
PFKLECOI_02066 5.3e-220 yqxK 3.6.4.12 L DNA helicase
PFKLECOI_02067 4.5e-58 ansR K Transcriptional regulator
PFKLECOI_02068 3.6e-185 ansA 3.5.1.1 EJ L-asparaginase
PFKLECOI_02069 6.4e-268 aspA 4.2.1.2, 4.3.1.1 E Aspartate ammonia-lyase
PFKLECOI_02070 3.1e-235 mleN C Na H antiporter
PFKLECOI_02071 1.6e-241 mleA 1.1.1.38 C malic enzyme
PFKLECOI_02072 4.2e-30 yqkK
PFKLECOI_02073 2.3e-108 spoIIM S Required for complete septum migration and engulfment of the forespore compartment during sporulation. Required for stabilizing and recruiting of SpoIIP to the septal membrane
PFKLECOI_02074 2.4e-80 fur P Belongs to the Fur family
PFKLECOI_02075 1.4e-36 S Protein of unknown function (DUF4227)
PFKLECOI_02076 1.6e-155 xerD L recombinase XerD
PFKLECOI_02077 3e-231 deoB 5.4.2.7 G Phosphotransfer between the C1 and C5 carbon atoms of pentose
PFKLECOI_02078 1.7e-148 punA 2.4.2.1 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
PFKLECOI_02079 2.4e-212 dacF 3.4.16.4 M Belongs to the peptidase S11 family
PFKLECOI_02080 5e-57 spoIIAA T Belongs to the anti-sigma-factor antagonist family
PFKLECOI_02081 1.8e-75 spoIIAB 2.7.11.1 F Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition
PFKLECOI_02082 2.4e-136 sigF K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PFKLECOI_02083 9.6e-112 spoVAA S Stage V sporulation protein AA
PFKLECOI_02084 1.3e-67 spoVAB S Stage V sporulation protein AB
PFKLECOI_02085 2.3e-78 spoVAC S stage V sporulation protein AC
PFKLECOI_02086 9e-192 spoVAD I Stage V sporulation protein AD
PFKLECOI_02087 2.2e-57 spoVAEB S stage V sporulation protein
PFKLECOI_02088 1.4e-110 spoVAEA S stage V sporulation protein
PFKLECOI_02089 1.4e-273 spoVAF EG Stage V sporulation protein AF
PFKLECOI_02090 5.2e-256 lysA 4.1.1.19, 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
PFKLECOI_02091 3.6e-149 ypuA S Secreted protein
PFKLECOI_02092 8e-81 ppiB 5.2.1.8 O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PFKLECOI_02095 4.7e-13 S PAP2 superfamily
PFKLECOI_02096 6.6e-33 yhcC S nucleic-acid-binding protein containing a Zn-ribbon domain
PFKLECOI_02097 5.2e-101 sipT 3.4.21.89 U Belongs to the peptidase S26 family
PFKLECOI_02098 7.8e-55 ypuD
PFKLECOI_02099 2.4e-203 ribD 1.1.1.193, 3.5.4.26 H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PFKLECOI_02100 7.4e-115 ribE 2.5.1.9 H Riboflavin synthase
PFKLECOI_02101 2.9e-229 ribBA 3.5.4.25, 4.1.99.12 H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PFKLECOI_02102 3.9e-81 ribH 2.5.1.78 H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
PFKLECOI_02103 4.5e-64 ribT K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
PFKLECOI_02104 1.2e-91 ypuF S Domain of unknown function (DUF309)
PFKLECOI_02105 1.4e-128 scpA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
PFKLECOI_02106 3.5e-103 scpB D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PFKLECOI_02107 7.6e-97 ypuI S Protein of unknown function (DUF3907)
PFKLECOI_02108 3e-212 dacB 3.4.16.4 M Belongs to the peptidase S11 family
PFKLECOI_02109 3.5e-103 spmA S Spore maturation protein
PFKLECOI_02110 5.4e-87 spmB S Spore maturation protein
PFKLECOI_02111 6.9e-133 rluB 5.4.99.19, 5.4.99.21, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
PFKLECOI_02112 1.3e-99 resA CO Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c
PFKLECOI_02113 0.0 ccs1 O COG1333 ResB protein required for cytochrome c biosynthesis
PFKLECOI_02114 8.8e-215 ccsA O 'COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component'
PFKLECOI_02115 2.3e-133 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
PFKLECOI_02116 0.0 resE 2.7.13.3 T Histidine kinase
PFKLECOI_02117 2.6e-103 sigX K Belongs to the sigma-70 factor family. ECF subfamily
PFKLECOI_02118 8.3e-199 rsiX
PFKLECOI_02119 3.4e-135 aroD 1.1.1.25, 4.2.1.10 E Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
PFKLECOI_02120 1.5e-294 serA 1.1.1.399, 1.1.1.95 E Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PFKLECOI_02121 5.8e-87 fmnP U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
PFKLECOI_02122 4.7e-41 fer C Ferredoxin
PFKLECOI_02123 3.8e-201 ypbB 5.1.3.1 S protein conserved in bacteria
PFKLECOI_02124 6.6e-284 recQ 3.6.4.12 L DNA helicase
PFKLECOI_02125 2.2e-100 ypbD S metal-dependent membrane protease
PFKLECOI_02126 4.6e-81 ypbE M Lysin motif
PFKLECOI_02127 1.1e-80 ypbF S Protein of unknown function (DUF2663)
PFKLECOI_02128 1.8e-144 ypbG S Calcineurin-like phosphoesterase superfamily domain
PFKLECOI_02129 2.4e-104 mecB NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC
PFKLECOI_02130 2.6e-244 gudB 1.4.1.2, 1.4.1.3 E Belongs to the Glu Leu Phe Val dehydrogenases family
PFKLECOI_02131 1.3e-174 ypdA 1.18.1.2, 1.19.1.1, 1.8.1.9 O COG0492 Thioredoxin reductase
PFKLECOI_02132 2.3e-119 prsW S Involved in the degradation of specific anti-sigma factors
PFKLECOI_02133 2.8e-152 sleB 3.5.1.28 M Spore cortex-lytic enzyme
PFKLECOI_02134 6.5e-254 hemX 2.1.1.107, 4.2.1.75 H sporulation protein
PFKLECOI_02135 1e-111 ypfA M Flagellar protein YcgR
PFKLECOI_02136 1.8e-23 S Family of unknown function (DUF5359)
PFKLECOI_02137 3.6e-112 cmk 1.17.7.4, 2.5.1.19, 2.7.1.26, 2.7.4.25, 2.7.7.2, 6.3.2.1 F Belongs to the cytidylate kinase family. Type 1 subfamily
PFKLECOI_02138 1.6e-205 rpsA 1.17.7.4 J Ribosomal protein S1
PFKLECOI_02139 1.1e-184 fni 1.1.1.88, 5.3.3.2 C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
PFKLECOI_02140 1.4e-07 S YpzI-like protein
PFKLECOI_02141 6.7e-102 yphA
PFKLECOI_02142 7.2e-161 seaA S YIEGIA protein
PFKLECOI_02143 7.9e-28 ypzH
PFKLECOI_02144 6.7e-248 der 1.1.1.399, 1.1.1.95 S GTPase that plays an essential role in the late steps of ribosome biogenesis
PFKLECOI_02145 1.2e-178 gpsA 1.1.1.94 I Glycerol-3-phosphate dehydrogenase
PFKLECOI_02146 1.2e-18 yphE S Protein of unknown function (DUF2768)
PFKLECOI_02147 5.4e-138 yphF
PFKLECOI_02148 3.7e-279 spoIVA S ATPase. Has a role at an early stage in the morphogenesis of the spore coat
PFKLECOI_02149 4.7e-42 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
PFKLECOI_02150 7.1e-101 folE 3.5.4.16 H GTP cyclohydrolase
PFKLECOI_02151 2.3e-34 mtrB K Required for transcription attenuation control in the Trp operon. This trans-acting factor seems to recognize a 10 bases nucleotide sequence in the Trp leader transcript causing transcription termination. Binds the leader RNA only in presence of L-tryptophan
PFKLECOI_02152 2.8e-137 hepS 2.5.1.30 H Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1
PFKLECOI_02153 8.6e-133 menG 2.1.1.163, 2.1.1.201 H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)
PFKLECOI_02154 4.5e-194 hepT 2.5.1.30, 2.5.1.83, 2.5.1.90 H Belongs to the FPP GGPP synthase family
PFKLECOI_02155 9.1e-80 ndk 2.7.4.6 F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
PFKLECOI_02156 1.1e-141 cheR 2.1.1.80 NT COG1352 Methylase of chemotaxis methyl-accepting proteins
PFKLECOI_02157 1.2e-216 aroC 4.2.3.5 E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PFKLECOI_02158 5.8e-205 aroB 2.7.1.71, 4.2.3.4 E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PFKLECOI_02159 1e-63 aroH 2.7.4.25, 5.4.99.5 E Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis
PFKLECOI_02160 4e-292 trpE 4.1.3.27 EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PFKLECOI_02161 1.2e-180 trpD 2.4.2.18, 4.1.3.27 E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PFKLECOI_02162 8.1e-113 trpC 4.1.1.48, 5.3.1.24 E Belongs to the TrpC family
PFKLECOI_02163 1.2e-117 trpF 4.1.1.48, 4.2.1.160, 4.2.1.20, 5.3.1.24 E Belongs to the TrpF family
PFKLECOI_02164 5.2e-231 trpB 4.2.1.20, 5.3.1.24 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
PFKLECOI_02165 1.2e-143 trpA 4.2.1.20 E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
PFKLECOI_02166 2.9e-204 hisC 2.6.1.9 E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PFKLECOI_02167 1.2e-208 tyrA 1.3.1.12, 1.3.1.43 E prephenate dehydrogenase
PFKLECOI_02168 3.8e-235 aroA 1.3.1.12, 1.3.1.43, 2.5.1.19 E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
PFKLECOI_02169 2.7e-233 S COG0457 FOG TPR repeat
PFKLECOI_02170 2.8e-99 ypiB S Belongs to the UPF0302 family
PFKLECOI_02171 1.4e-75 ypiF S Protein of unknown function (DUF2487)
PFKLECOI_02172 9.3e-97 qcrA C Menaquinol-cytochrome c reductase
PFKLECOI_02173 5.2e-127 petB C COG1290 Cytochrome b subunit of the bc complex
PFKLECOI_02174 1.5e-146 qcrC C Menaquinol-cytochrome c reductase cytochrome b c subunit
PFKLECOI_02175 3.4e-98 ypjA S membrane
PFKLECOI_02176 1e-142 ypjB S sporulation protein
PFKLECOI_02177 8.1e-157 ypjC S Uncharacterized protein conserved in bacteria (DUF2179)
PFKLECOI_02178 6.9e-56 ypjD 2.5.1.19 S Nucleotide pyrophosphohydrolase
PFKLECOI_02179 1.8e-147 dapB 1.17.1.8 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
PFKLECOI_02180 7.9e-70 mgsA 2.7.1.24, 4.2.3.3 G methylglyoxal synthase
PFKLECOI_02181 1.3e-128 bshB1 S proteins, LmbE homologs
PFKLECOI_02182 2.6e-208 bshA GT4 M N-acetyl-alpha-D-glucosaminyl L-malate synthase
PFKLECOI_02183 3.9e-218 cca 2.7.7.19, 2.7.7.72 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
PFKLECOI_02184 8.7e-184 birA 6.3.4.15 K Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
PFKLECOI_02185 1.4e-150 panB 2.1.2.11 H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
PFKLECOI_02186 1.2e-157 panC 2.7.4.25, 6.3.2.1 H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PFKLECOI_02187 3.5e-64 panD 4.1.1.11 H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
PFKLECOI_02188 0.0 dinG 2.7.7.7, 3.6.4.12 L helicase involved in DNA repair and perhaps also replication
PFKLECOI_02189 1.9e-22 ypmA S Protein of unknown function (DUF4264)
PFKLECOI_02190 2.2e-79 ypmB S protein conserved in bacteria
PFKLECOI_02191 7.4e-222 aspB 2.6.1.1, 2.6.1.14 E Aminotransferase
PFKLECOI_02192 5.8e-252 asnS 6.1.1.22 J asparaginyl-tRNA
PFKLECOI_02193 5.7e-129 dnaD L DNA replication protein DnaD
PFKLECOI_02194 2.2e-122 nth 4.2.99.18 L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PFKLECOI_02195 4.7e-93 ypoC
PFKLECOI_02196 0.0 ponA 2.4.1.129, 2.7.7.7, 3.4.16.4 GT51 M penicillin-binding protein
PFKLECOI_02197 1.2e-114 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
PFKLECOI_02198 1e-184 yppC S Protein of unknown function (DUF2515)
PFKLECOI_02201 5.7e-11 yppE S Bacterial domain of unknown function (DUF1798)
PFKLECOI_02203 1.2e-48 yppG S YppG-like protein
PFKLECOI_02204 8.6e-72 hspX O Belongs to the small heat shock protein (HSP20) family
PFKLECOI_02205 2.3e-80 ypqE 2.7.1.199 G COG2190 Phosphotransferase system IIA components
PFKLECOI_02206 0.0 yprA L COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster
PFKLECOI_02207 7.3e-236 yprB L RNase_H superfamily
PFKLECOI_02208 2.8e-91 ypsA S Belongs to the UPF0398 family
PFKLECOI_02209 2.8e-45 gpsB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
PFKLECOI_02210 3.9e-223 rlmL 2.1.1.173, 2.1.1.264 L Belongs to the methyltransferase superfamily
PFKLECOI_02212 0.0 ypvA 3.6.4.12 KL COG1199 Rad3-related DNA helicases
PFKLECOI_02213 3.5e-132 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
PFKLECOI_02214 6.3e-159 kduI 5.3.1.17 G Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
PFKLECOI_02215 8.2e-185 ptxS K transcriptional
PFKLECOI_02216 2.4e-186 kdgK 2.7.1.45 G COG0524 Sugar kinases, ribokinase family
PFKLECOI_02217 4.6e-103 eda 2.7.1.45, 4.1.2.14, 4.1.3.42 G 2-dehydro-3-deoxy-phosphogluconate aldolase
PFKLECOI_02218 2.1e-169 kdgT P The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system
PFKLECOI_02219 9.6e-291 ypwA 3.4.17.19 E Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
PFKLECOI_02220 8.8e-99 xpt 2.4.2.22, 2.4.2.7 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
PFKLECOI_02221 1.6e-228 pbuX F xanthine
PFKLECOI_02222 4.4e-208 bcsA Q Naringenin-chalcone synthase
PFKLECOI_02223 5.1e-87 ypbQ S protein conserved in bacteria
PFKLECOI_02224 0.0 ypbR S Dynamin family
PFKLECOI_02225 1e-38 ypbS S Protein of unknown function (DUF2533)
PFKLECOI_02226 2e-07
PFKLECOI_02227 1.5e-166 polA 2.7.7.7 L 5'3' exonuclease
PFKLECOI_02229 2.7e-67 rnhA 3.1.26.4 L Ribonuclease
PFKLECOI_02230 2.9e-105 ypdP S Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
PFKLECOI_02231 1e-134 ypeP 3.1.26.4 L COG0328 Ribonuclease HI
PFKLECOI_02232 2.6e-27 ypeQ S Zinc-finger
PFKLECOI_02233 5.2e-30 S Protein of unknown function (DUF2564)
PFKLECOI_02234 3.8e-16 degR
PFKLECOI_02235 7.9e-31 cspD K Cold-shock protein
PFKLECOI_02236 2e-216 ugtP 2.4.1.315 GT28 M Processive glucosyltransferase involved in the biosynthesis of both the bilayer- and non-bilayer-forming membrane glucolipids. Is able to successively transfer up to three glucosyl residues to diacylglycerol (DAG), thereby catalyzing the formation of beta-monoglucosyl-DAG (3-O-(beta-D-glucopyranosyl)-1,2-diacyl- sn-glycerol), beta-diglucosyl-DAG (3-O-(beta-D-glucopyranosyl- beta-(1- 6)-D-glucopyranosyl)-1,2-diacyl-sn-glycerol) and beta- triglucosyl-DAG (3-O-(beta-D-glucopyranosyl-beta-(1- 6)-D- glucopyranosyl-beta-(1- 6)-D-glucopyranosyl)-1,2-diacyl-sn- glycerol). Beta-diglucosyl-DAG is the predominant glycolipid found in Bacillales and is also used as a membrane anchor for lipoteichoic acid (LTA)
PFKLECOI_02238 7.3e-177 metAA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PFKLECOI_02239 1.5e-88 btuE 1.11.1.9 O Belongs to the glutathione peroxidase family
PFKLECOI_02240 2.1e-106 ypgQ S phosphohydrolase
PFKLECOI_02241 5.2e-156 ypgR C COG0694 Thioredoxin-like proteins and domains
PFKLECOI_02242 0.0 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
PFKLECOI_02243 1.7e-75 yphP S Belongs to the UPF0403 family
PFKLECOI_02244 1.6e-143 ypiP 2.1.1.242 AJ Putative SAM-dependent methyltransferase
PFKLECOI_02245 8.6e-113 ypjP S YpjP-like protein
PFKLECOI_02246 3.3e-92 pgpA 3.1.3.27 I COG1267 Phosphatidylglycerophosphatase A and related proteins
PFKLECOI_02247 7.6e-154 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PFKLECOI_02248 1.6e-93 folA 1.1.1.262, 1.5.1.3 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
PFKLECOI_02249 1.1e-110 ypkP 2.3.1.51 I Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family
PFKLECOI_02250 4.2e-110 hlyIII S protein, Hemolysin III
PFKLECOI_02251 6.1e-185 pspF K Transcriptional regulator
PFKLECOI_02252 9.7e-244 ilvA 4.3.1.19 E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PFKLECOI_02253 3.1e-40 ypmP S Protein of unknown function (DUF2535)
PFKLECOI_02254 1.2e-108 ypmQ S protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems
PFKLECOI_02255 1.1e-136 ypmR E GDSL-like Lipase/Acylhydrolase
PFKLECOI_02256 5.5e-98 ypmS S protein conserved in bacteria
PFKLECOI_02257 5.5e-29 ypmT S Uncharacterized ympT
PFKLECOI_02258 1.3e-222 mepA V MATE efflux family protein
PFKLECOI_02259 1.6e-70 ypoP K transcriptional
PFKLECOI_02260 3.5e-102 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PFKLECOI_02261 1.3e-78 msrB 1.8.4.11, 1.8.4.12 O peptide methionine sulfoxide reductase
PFKLECOI_02262 5.6e-125 4.2.1.115 GM Polysaccharide biosynthesis protein
PFKLECOI_02263 3.4e-211 phy 3.1.3.8 I Myo-inositol-hexaphosphate 3-phosphohydrolase
PFKLECOI_02264 2.2e-187 cgeB S Spore maturation protein
PFKLECOI_02265 1.2e-65 cgeA
PFKLECOI_02266 3.5e-38 cgeC
PFKLECOI_02267 1.1e-255 cgeD M maturation of the outermost layer of the spore
PFKLECOI_02268 1.8e-144 yiiD K acetyltransferase
PFKLECOI_02270 5.8e-247 yodT H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PFKLECOI_02271 6.5e-125 yodS 2.8.3.8, 2.8.3.9 I COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PFKLECOI_02272 8.9e-116 scoB 2.8.3.5, 2.8.3.8, 2.8.3.9 I COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit
PFKLECOI_02273 3.5e-257 yodQ 3.5.1.16 E Acetylornithine deacetylase
PFKLECOI_02274 3e-153 yodP 2.3.1.264 K Acetyltransferase (GNAT) family
PFKLECOI_02275 4.4e-277 kamA 5.4.3.2 E lysine 2,3-aminomutase
PFKLECOI_02276 8.3e-47 yokU S YokU-like protein, putative antitoxin
PFKLECOI_02277 1.4e-36 yozE S Belongs to the UPF0346 family
PFKLECOI_02278 1.6e-123 yodN
PFKLECOI_02280 2.8e-24 yozD S YozD-like protein
PFKLECOI_02281 2e-106 yodM 3.6.1.27 I Acid phosphatase homologues
PFKLECOI_02282 3.6e-54 yodL S YodL-like
PFKLECOI_02283 5.3e-09
PFKLECOI_02284 3.2e-127 deoD 2.4.2.1, 2.4.2.28 F Purine nucleoside phosphorylase
PFKLECOI_02285 5.5e-139 vanY 3.4.17.14 M D-alanyl-D-alanine carboxypeptidase
PFKLECOI_02286 1.5e-23 yodI
PFKLECOI_02287 6.3e-128 yodH Q Methyltransferase
PFKLECOI_02288 2.8e-252 ctpA 3.4.21.102 M Belongs to the peptidase S41A family
PFKLECOI_02289 4.3e-267 yodF E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PFKLECOI_02290 6.2e-28 S Protein of unknown function (DUF3311)
PFKLECOI_02291 3.2e-172 yodE E COG0346 Lactoylglutathione lyase and related lyases
PFKLECOI_02292 1.2e-111 mhqD S Carboxylesterase
PFKLECOI_02293 1.4e-107 yodC C nitroreductase
PFKLECOI_02294 4.4e-55 yodB K transcriptional
PFKLECOI_02295 8e-64 yodA S tautomerase
PFKLECOI_02296 3.8e-206 gntP EG COG2610 H gluconate symporter and related permeases
PFKLECOI_02297 3.4e-09
PFKLECOI_02298 1.1e-64 yozR S COG0071 Molecular chaperone (small heat shock protein)
PFKLECOI_02299 5.6e-161 rarD S -transporter
PFKLECOI_02300 1.5e-43
PFKLECOI_02301 2.2e-60 yojF S Protein of unknown function (DUF1806)
PFKLECOI_02302 2.1e-125 yojG S deacetylase
PFKLECOI_02303 3.2e-150 T COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
PFKLECOI_02304 1e-243 norM V Multidrug efflux pump
PFKLECOI_02306 1.2e-109 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
PFKLECOI_02307 5.3e-231 yojK CG UDP-glucoronosyl and UDP-glucosyl transferase
PFKLECOI_02308 2.5e-196 sle1 3.5.1.28 CBM50 M COG1388 FOG LysM repeat
PFKLECOI_02309 6.6e-110 sodC 1.15.1.1 P Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PFKLECOI_02310 1.5e-161 yojN S ATPase family associated with various cellular activities (AAA)
PFKLECOI_02311 0.0 yojO P Von Willebrand factor
PFKLECOI_02312 0.0 sucA 1.2.4.2, 4.1.1.71 C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)
PFKLECOI_02313 2e-193 sucB 2.3.1.61 C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)
PFKLECOI_02314 5.1e-168 yocS S -transporter
PFKLECOI_02315 4.5e-231 yocR S Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
PFKLECOI_02316 1.3e-164 sodA 1.15.1.1 P Superoxide dismutase
PFKLECOI_02317 0.0 sqhC 4.2.1.137, 5.4.99.7 I COG1657 Squalene cyclase
PFKLECOI_02318 2e-288 dhaS 1.2.1.3, 1.2.1.39 C Belongs to the aldehyde dehydrogenase family
PFKLECOI_02319 2.7e-31 yozC
PFKLECOI_02320 4.2e-56 yozO S Bacterial PH domain
PFKLECOI_02321 1.9e-36 yocN
PFKLECOI_02322 1.1e-40 yozN
PFKLECOI_02323 1.3e-87 yocM O Belongs to the small heat shock protein (HSP20) family
PFKLECOI_02324 6.2e-32
PFKLECOI_02325 6.4e-54 yocL
PFKLECOI_02326 3.3e-83 dksA T general stress protein
PFKLECOI_02327 7.9e-114 azoR I Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PFKLECOI_02328 0.0 recQ 3.6.4.12 L DNA helicase
PFKLECOI_02329 7.1e-113 yocH CBM50 M COG1388 FOG LysM repeat
PFKLECOI_02330 1e-105 desR T COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
PFKLECOI_02331 1.7e-196 desK 2.7.13.3 T Histidine kinase
PFKLECOI_02332 1e-201 des 1.14.19.23, 1.14.19.45 I fatty acid desaturase
PFKLECOI_02333 3.2e-186 yocD 3.4.17.13 V peptidase S66
PFKLECOI_02334 1.6e-93 yocC
PFKLECOI_02335 6.4e-145
PFKLECOI_02336 1.5e-92 yozB S membrane
PFKLECOI_02337 4.4e-118 pvaA M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)
PFKLECOI_02338 1e-51 czrA K transcriptional
PFKLECOI_02339 1e-93 yobW
PFKLECOI_02340 6.4e-176 yobV K WYL domain
PFKLECOI_02341 8.3e-87 yobU K Bacterial transcription activator, effector binding domain
PFKLECOI_02342 1.6e-129 yobT S COG0491 Zn-dependent hydrolases, including glyoxylases
PFKLECOI_02343 3.6e-97 yobS K Transcriptional regulator
PFKLECOI_02344 2.6e-140 yobR 2.3.1.1 J FR47-like protein
PFKLECOI_02345 7.9e-137 yobQ K helix_turn_helix, arabinose operon control protein
PFKLECOI_02346 9.3e-53 csaA 6.1.1.10, 6.1.1.20, 6.1.1.6 J tRNA-binding protein
PFKLECOI_02347 8.3e-276 iaaM 1.4.3.4 E COG1231 Monoamine oxidase
PFKLECOI_02348 3.7e-102 yokH G SMI1 / KNR4 family
PFKLECOI_02349 4.4e-17 L A nuclease of the HNH/ENDO VII superfamily with conserved LHH
PFKLECOI_02350 6.9e-19
PFKLECOI_02352 6.7e-95 S aspartate phosphatase
PFKLECOI_02354 8.1e-18
PFKLECOI_02355 2.1e-66 yoaQ S Evidence 4 Homologs of previously reported genes of
PFKLECOI_02357 2.5e-116
PFKLECOI_02358 9.5e-50 FG Scavenger mRNA decapping enzyme C-term binding
PFKLECOI_02361 1.5e-53 K Helix-turn-helix
PFKLECOI_02362 8.8e-37 S TM2 domain
PFKLECOI_02363 4e-121 xlnB 3.2.1.8 G Glycosyl hydrolases family 11
PFKLECOI_02364 0.0 pps 2.7.9.2 GT phosphoenolpyruvate synthase
PFKLECOI_02367 5e-165 bla 3.5.2.6 V beta-lactamase
PFKLECOI_02368 5.2e-113 yoaZ 1.11.1.6, 3.5.1.124 S DJ-1/PfpI family
PFKLECOI_02369 1.8e-77 yoaW
PFKLECOI_02370 5.6e-158 yijE EG EamA-like transporter family
PFKLECOI_02371 4.3e-158 yoaU K LysR substrate binding domain
PFKLECOI_02372 1.4e-147 yoaT S Protein of unknown function (DUF817)
PFKLECOI_02373 4.2e-37 yozG K Transcriptional regulator
PFKLECOI_02374 2.1e-74 yoaS S Protein of unknown function (DUF2975)
PFKLECOI_02375 7.1e-172 yoaR V vancomycin resistance protein
PFKLECOI_02376 4.3e-86
PFKLECOI_02378 2e-66 yoaQ S Evidence 4 Homologs of previously reported genes of
PFKLECOI_02379 1.4e-144 yoaP 3.1.3.18 K YoaP-like
PFKLECOI_02381 8.2e-229 oxdC 4.1.1.2 G Oxalate decarboxylase
PFKLECOI_02384 3.5e-131 yoqW S Belongs to the SOS response-associated peptidase family
PFKLECOI_02385 8.1e-196 pelB 4.2.2.10, 4.2.2.2 G Amb_all
PFKLECOI_02386 2.3e-111 yoaK S Membrane
PFKLECOI_02387 3.8e-133 yoaJ G Endoglucanase C-terminal domain subunit and related proteins
PFKLECOI_02388 2.1e-279 hpaB 1.14.14.9 Q COG2368 Aromatic ring hydroxylase
PFKLECOI_02389 2.8e-182 mcpU NT methyl-accepting chemotaxis protein
PFKLECOI_02390 7.7e-35 S Protein of unknown function (DUF4025)
PFKLECOI_02391 7.7e-13
PFKLECOI_02392 6.5e-08 ywlA S Uncharacterised protein family (UPF0715)
PFKLECOI_02393 1.9e-33 yoaF
PFKLECOI_02394 0.0 yoaE C belongs to the prokaryotic molybdopterin-containing oxidoreductase family
PFKLECOI_02395 4.7e-185 yoaD 1.1.1.399, 1.1.1.95 EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PFKLECOI_02396 1.4e-278 yoaC 2.7.1.12, 2.7.1.17, 2.7.1.189, 2.7.1.5 G FGGY family of carbohydrate kinases, C-terminal domain
PFKLECOI_02397 4.4e-233 yoaB EGP Major facilitator Superfamily
PFKLECOI_02398 1.9e-126 3.1.1.3 I Lipase (class 3)
PFKLECOI_02399 7.5e-242 S Arylsulfotransferase (ASST)
PFKLECOI_02400 1.5e-92 yoaA 2.3.1.128 J COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
PFKLECOI_02401 1.3e-94 yoxB
PFKLECOI_02402 3.1e-24 yoxB
PFKLECOI_02403 8.3e-40 yoxC S Bacterial protein of unknown function (DUF948)
PFKLECOI_02404 2.4e-122 fabG 1.1.1.100 S Belongs to the short-chain dehydrogenases reductases (SDR) family
PFKLECOI_02405 1.9e-59 rtp K Plays a role in DNA replication and termination (fork arrest mechanism). Two dimers of rtp bind to the two inverted repeat regions (IRI and IRII) present in the termination site. The binding of each dimer is centered on an 8 bp direct repeat
PFKLECOI_02406 2.5e-144 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PFKLECOI_02407 6e-205 proB 2.7.2.11 E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PFKLECOI_02408 7.8e-155 gltC K Transcriptional regulator
PFKLECOI_02409 0.0 gltB 1.4.1.13, 1.4.1.14, 1.4.7.1 E glutamate synthase
PFKLECOI_02410 1.9e-291 gltD 1.4.1.13, 1.4.1.14 E COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases
PFKLECOI_02411 1.9e-186 yogA C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases
PFKLECOI_02412 2.7e-157 gltR1 K Transcriptional regulator
PFKLECOI_02413 0.0 ggt 2.3.2.2, 3.4.19.13 E gamma-glutamyltransferase
PFKLECOI_02414 3e-34 yoeD G Helix-turn-helix domain
PFKLECOI_02415 2.2e-96 L Integrase
PFKLECOI_02417 1.1e-98 yoeB S IseA DL-endopeptidase inhibitor
PFKLECOI_02418 2.3e-246 yoeA V MATE efflux family protein
PFKLECOI_02419 6.9e-189 yoxA 5.1.3.3 G Aldose 1-epimerase
PFKLECOI_02420 1.8e-273 dacC 3.4.16.4 M D-alanyl-D-alanine carboxypeptidase
PFKLECOI_02421 4.2e-64 K BetI-type transcriptional repressor, C-terminal
PFKLECOI_02422 4.6e-140 yhfP 1.1.1.1 C Alcohol dehydrogenase GroES-like domain
PFKLECOI_02423 1.3e-22 L Helix-turn-helix domain of resolvase
PFKLECOI_02424 4e-77 arsC 1.20.4.1 T Catalyzes the reduction of arsenate As(V) to arsenite As(III)
PFKLECOI_02425 1.3e-182 arsB 1.20.4.1 P Arsenic resistance protein
PFKLECOI_02426 1.4e-64 cadI 4.4.1.5 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PFKLECOI_02427 2.1e-54 arsR K ArsR family transcriptional regulator
PFKLECOI_02430 1.4e-156 S Aspartate phosphatase response regulator
PFKLECOI_02432 1.3e-138 yvgN 1.1.1.346 S Reductase
PFKLECOI_02433 1e-70 K MerR family transcriptional regulator
PFKLECOI_02434 0.0 L A nuclease of the HNH/ENDO VII superfamily with conserved LHH
PFKLECOI_02435 1.8e-83 S SMI1-KNR4 cell-wall
PFKLECOI_02436 1.2e-118 EGP Necrosis inducing protein (NPP1)
PFKLECOI_02437 9e-133 xlyB 3.5.1.104, 3.5.1.28 M N-acetylmuramoyl-L-alanine amidase
PFKLECOI_02438 1.3e-27 S phage terminase, large subunit
PFKLECOI_02439 8.6e-73 yqaS L DNA packaging
PFKLECOI_02441 3.7e-26 cotD S Inner spore coat protein D
PFKLECOI_02442 1.9e-40 L Transposase
PFKLECOI_02445 1.3e-38 xkdC L IstB-like ATP binding protein
PFKLECOI_02447 8.4e-159 axeA S Carbohydrate esterase, sialic acid-specific acetylesterase
PFKLECOI_02448 1.7e-88 K Transcriptional regulator PadR-like family
PFKLECOI_02449 7.6e-97 adk 2.7.4.3 F adenylate kinase activity
PFKLECOI_02451 4.9e-44 yqaB E IrrE N-terminal-like domain
PFKLECOI_02454 3.8e-36 L Phage integrase, N-terminal SAM-like domain
PFKLECOI_02456 3.6e-27
PFKLECOI_02459 2.2e-56 K DNA binding
PFKLECOI_02460 2.4e-123 2.1.1.37 L Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family
PFKLECOI_02461 9e-17
PFKLECOI_02463 3.2e-29
PFKLECOI_02465 4.4e-18 xkdU S Uncharacterised protein conserved in bacteria (DUF2313)
PFKLECOI_02466 2.5e-14
PFKLECOI_02467 1.2e-40
PFKLECOI_02468 2.9e-145 A Pre-toxin TG
PFKLECOI_02469 5.2e-39 A Pre-toxin TG
PFKLECOI_02470 5.7e-25
PFKLECOI_02471 9.3e-59
PFKLECOI_02472 2e-08
PFKLECOI_02473 2.6e-59 sigK K sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PFKLECOI_02474 2e-68 psiE S Protein PsiE homolog
PFKLECOI_02475 9e-237 yrkQ T Histidine kinase
PFKLECOI_02476 1.1e-127 T Transcriptional regulator
PFKLECOI_02477 8.2e-224 yrkO P Protein of unknown function (DUF418)
PFKLECOI_02478 2.3e-104 yrkN K Acetyltransferase (GNAT) family
PFKLECOI_02479 1.5e-97 ywrO S Flavodoxin-like fold
PFKLECOI_02480 2.8e-79 S Protein of unknown function with HXXEE motif
PFKLECOI_02481 5.4e-112 yrkJ S membrane transporter protein
PFKLECOI_02482 5.4e-36 yrkI O Belongs to the sulfur carrier protein TusA family
PFKLECOI_02483 6e-205 yrkH P Rhodanese Homology Domain
PFKLECOI_02484 7.9e-45 perX S DsrE/DsrF-like family
PFKLECOI_02485 1.1e-95 yrkF OP Belongs to the sulfur carrier protein TusA family
PFKLECOI_02486 5.6e-83 yrkE O DsrE/DsrF/DrsH-like family
PFKLECOI_02487 7.8e-39 yrkD S protein conserved in bacteria
PFKLECOI_02488 4.9e-107 yrkC G Cupin domain
PFKLECOI_02489 3.1e-150 bltR K helix_turn_helix, mercury resistance
PFKLECOI_02490 3.5e-211 blt EGP Major facilitator Superfamily
PFKLECOI_02491 5.9e-82 bltD 2.3.1.57 K FR47-like protein
PFKLECOI_02492 2.2e-235 corC1 S COG1253 Hemolysins and related proteins containing CBS domains
PFKLECOI_02493 3.9e-16 S YrzO-like protein
PFKLECOI_02494 1.4e-170 yrdR EG EamA-like transporter family
PFKLECOI_02495 5.6e-158 yrdQ K Transcriptional regulator
PFKLECOI_02496 3.3e-197 trkA P Oxidoreductase
PFKLECOI_02497 2.2e-147 czcD P COG1230 Co Zn Cd efflux system component
PFKLECOI_02498 3.2e-65 yodA S tautomerase
PFKLECOI_02499 5e-162 gltR K LysR substrate binding domain
PFKLECOI_02500 3.3e-226 brnQ E Component of the transport system for branched-chain amino acids
PFKLECOI_02501 2.5e-50 azlD E Branched-chain amino acid transport protein (AzlD)
PFKLECOI_02502 2.8e-137 azlC E AzlC protein
PFKLECOI_02503 1.1e-78 bkdR K helix_turn_helix ASNC type
PFKLECOI_02504 8.3e-24 yrdF K ribonuclease inhibitor
PFKLECOI_02505 1.2e-230 cypA C Cytochrome P450
PFKLECOI_02507 1e-99 yrdC 3.5.1.19 Q Isochorismatase family
PFKLECOI_02508 4.4e-54 S Protein of unknown function (DUF2568)
PFKLECOI_02509 1.4e-89 yrdA S DinB family
PFKLECOI_02510 1.2e-165 aadK G Streptomycin adenylyltransferase
PFKLECOI_02511 2.4e-192 yrpB 1.13.12.16 S COG2070 Dioxygenases related to 2-nitropropane dioxygenase
PFKLECOI_02512 2.7e-79 murI 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
PFKLECOI_02513 1.6e-123 yrpD S Domain of unknown function, YrpD
PFKLECOI_02515 3.8e-94 adcA S ZinT (YodA) periplasmic lipocalin-like zinc-recruitment
PFKLECOI_02516 9.1e-95 sigZ K Belongs to the sigma-70 factor family. ECF subfamily
PFKLECOI_02517 1.7e-187 yrpG C Aldo/keto reductase family
PFKLECOI_02518 1.5e-223 yraO C Citrate transporter
PFKLECOI_02519 3.7e-162 yraN K Transcriptional regulator
PFKLECOI_02520 6.5e-204 yraM S PrpF protein
PFKLECOI_02521 1.7e-156 csn 3.2.1.132 M Aids in the defense against invading fungal pathogens by degrading their cell wall chitosan
PFKLECOI_02522 7.6e-42 yraL S COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
PFKLECOI_02523 6e-154 S Alpha beta hydrolase
PFKLECOI_02524 1.7e-60 T sh3 domain protein
PFKLECOI_02525 2.4e-61 T sh3 domain protein
PFKLECOI_02527 3.6e-64 E Glyoxalase-like domain
PFKLECOI_02528 1.5e-36 yraG
PFKLECOI_02529 6.4e-63 yraF M Spore coat protein
PFKLECOI_02530 2.9e-223 adhB 1.1.1.1, 1.1.1.14, 1.1.1.284, 1.2.1.46 E COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
PFKLECOI_02531 7.5e-26 yraE
PFKLECOI_02532 1.1e-49 yraD M Spore coat protein
PFKLECOI_02533 2.8e-46 yraB K helix_turn_helix, mercury resistance
PFKLECOI_02534 9.3e-200 adhA 1.1.1.1 C alcohol dehydrogenase
PFKLECOI_02535 5e-90 yhbO 1.11.1.6, 3.5.1.124 S protease
PFKLECOI_02536 0.0 sacC 3.2.1.26, 3.2.1.65, 3.2.1.80 GH32 G Belongs to the glycosyl hydrolase 32 family
PFKLECOI_02537 1.5e-152 manZ G COG3716 Phosphotransferase system, mannose fructose N-acetylgalactosamine-specific component IID
PFKLECOI_02538 4.4e-117 manY G COG3715 Phosphotransferase system, mannose fructose N-acetylgalactosamine-specific component IIC
PFKLECOI_02539 6.9e-81 levE 2.7.1.202 G PTS system mannose fructose sorbose family
PFKLECOI_02540 3.9e-75 levD 2.7.1.202 G PTS system fructose IIA component
PFKLECOI_02541 0.0 levR K PTS system fructose IIA component
PFKLECOI_02542 1.9e-253 cycA E COG1113 Gamma-aminobutyrate permease and related permeases
PFKLECOI_02543 1.1e-105 yrhP E LysE type translocator
PFKLECOI_02544 7e-150 yrhO K Archaeal transcriptional regulator TrmB
PFKLECOI_02545 4.3e-86 sigV K Belongs to the sigma-70 factor family. ECF subfamily
PFKLECOI_02546 8e-149 rsiV S Protein of unknown function (DUF3298)
PFKLECOI_02547 0.0 yrhL I Acyltransferase family
PFKLECOI_02548 5.6e-46 yrhK S YrhK-like protein
PFKLECOI_02549 0.0 cypD 1.14.14.1, 1.6.2.4 C Belongs to the cytochrome P450 family
PFKLECOI_02550 1.8e-104 Z012_03230 K Tetracycline repressor, C-terminal all-alpha domain
PFKLECOI_02551 3.6e-94 yrhH Q methyltransferase
PFKLECOI_02554 3e-142 focA P Formate nitrite
PFKLECOI_02556 2.3e-60 yrhF S Uncharacterized conserved protein (DUF2294)
PFKLECOI_02557 0.0 fdhA 1.17.1.10, 1.17.1.9 C formate dehydrogenase (NAD+) activity
PFKLECOI_02558 1.4e-78 yrhD S Protein of unknown function (DUF1641)
PFKLECOI_02559 4.6e-35 yrhC S YrhC-like protein
PFKLECOI_02560 3.7e-210 mccB 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
PFKLECOI_02561 6.1e-171 mccA 2.5.1.134, 2.5.1.47 E Cysteine synthase
PFKLECOI_02562 4.2e-124 mtnN 3.2.2.9 E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PFKLECOI_02563 7.6e-120 yrrT 4.4.1.21 Q Could be a S-adenosyl-L-methionine-dependent methyltransferase
PFKLECOI_02564 1e-25 yrzA S Protein of unknown function (DUF2536)
PFKLECOI_02565 4.2e-63 yrrS S Protein of unknown function (DUF1510)
PFKLECOI_02566 0.0 pbpI 3.4.16.4 M Penicillin-binding Protein
PFKLECOI_02567 2.4e-78 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
PFKLECOI_02568 4.7e-114 udk 2.7.1.48 F Cytidine monophosphokinase
PFKLECOI_02569 2.7e-246 yegQ O COG0826 Collagenase and related proteases
PFKLECOI_02570 2.9e-173 yegQ O Peptidase U32
PFKLECOI_02571 2.3e-119 yrrM 2.1.1.104 S O-methyltransferase
PFKLECOI_02572 8.2e-183 mltG S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PFKLECOI_02573 1.2e-45 yrzB S Belongs to the UPF0473 family
PFKLECOI_02574 2.1e-70 yqgF L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PFKLECOI_02575 1.7e-41 yrzL S Belongs to the UPF0297 family
PFKLECOI_02576 0.0 alaS 6.1.1.7 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PFKLECOI_02577 2.7e-170 yrrI S AI-2E family transporter
PFKLECOI_02578 1.3e-131 glnQ 3.6.3.21 E COG1126 ABC-type polar amino acid transport system, ATPase component
PFKLECOI_02579 5.7e-144 glnH ET Belongs to the bacterial solute-binding protein 3 family
PFKLECOI_02580 3.6e-109 gluC P ABC transporter
PFKLECOI_02581 7.6e-107 glnP P ABC transporter
PFKLECOI_02582 8e-08 S Protein of unknown function (DUF3918)
PFKLECOI_02583 9.8e-31 yrzR
PFKLECOI_02584 3e-81 yrrD S protein conserved in bacteria
PFKLECOI_02585 0.0 recD2 3.1.11.5 L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
PFKLECOI_02586 1.4e-15 S COG0457 FOG TPR repeat
PFKLECOI_02587 2.3e-220 mnmA 2.8.1.13 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
PFKLECOI_02588 2.6e-211 iscS 2.8.1.7 E Cysteine desulfurase
PFKLECOI_02589 1.2e-70 cymR K Transcriptional regulator
PFKLECOI_02590 2e-236 rarA L COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase
PFKLECOI_02591 9e-136 yrvM H COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1
PFKLECOI_02592 0.0 aspS 6.1.1.12 J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PFKLECOI_02593 5.2e-245 hisS 6.1.1.21 J histidyl-tRNA synthetase
PFKLECOI_02595 3.9e-263 lytH 3.5.1.28 M COG3103 SH3 domain protein
PFKLECOI_02596 2.9e-70 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
PFKLECOI_02597 0.0 relA 2.7.6.5 KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PFKLECOI_02598 5.9e-91 apt 2.4.2.22, 2.4.2.7 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PFKLECOI_02599 0.0 recJ L Single-stranded-DNA-specific exonuclease RecJ
PFKLECOI_02600 1.3e-48 yrvD S Lipopolysaccharide assembly protein A domain
PFKLECOI_02601 3.9e-87 yrvC P regulatory, ligand-binding protein related to C-terminal domains of K channels
PFKLECOI_02602 0.0 secF U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PFKLECOI_02603 9.4e-49 yrzD S Post-transcriptional regulator
PFKLECOI_02604 1.7e-269 spoVB S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
PFKLECOI_02605 2.2e-114 yrbG S membrane
PFKLECOI_02606 1.2e-74 yrzE S Protein of unknown function (DUF3792)
PFKLECOI_02607 1.1e-38 yajC U Preprotein translocase subunit YajC
PFKLECOI_02608 5.2e-228 tgt 2.4.2.29 F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
PFKLECOI_02609 2e-194 queA 2.4.99.17 J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PFKLECOI_02610 2.6e-18 yrzS S Protein of unknown function (DUF2905)
PFKLECOI_02611 6.6e-187 ruvB 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
PFKLECOI_02612 1.6e-106 ruvA 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
PFKLECOI_02613 4.8e-93 bofC S BofC C-terminal domain
PFKLECOI_02614 5.3e-253 csbX EGP Major facilitator Superfamily
PFKLECOI_02615 2.8e-193 iolG 1.1.1.18, 1.1.1.369 S Oxidoreductase family, NAD-binding Rossmann fold
PFKLECOI_02616 6.5e-119 yrzF T serine threonine protein kinase
PFKLECOI_02618 1.5e-50 S Family of unknown function (DUF5412)
PFKLECOI_02620 2e-261 alsT E Sodium alanine symporter
PFKLECOI_02621 1.9e-127 yebC K transcriptional regulatory protein
PFKLECOI_02622 3.8e-49 S Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
PFKLECOI_02623 9.8e-158 safA M spore coat assembly protein SafA
PFKLECOI_02624 2.8e-215 nadA 2.5.1.72 H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PFKLECOI_02625 4.7e-157 nadC 1.4.3.16, 2.4.2.19 H Belongs to the NadC ModD family
PFKLECOI_02626 4.4e-302 nadB 1.3.5.4, 1.4.3.16 H Catalyzes the oxidation of L-aspartate to iminoaspartate
PFKLECOI_02627 3.1e-228 nifS 2.8.1.7 E Cysteine desulfurase
PFKLECOI_02628 2.3e-93 niaR S small molecule binding protein (contains 3H domain)
PFKLECOI_02629 3.4e-163 pheA 4.2.1.51 E Prephenate dehydratase
PFKLECOI_02630 2.2e-73 pheB 5.4.99.5 S Belongs to the UPF0735 family
PFKLECOI_02631 9.6e-231 obg S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PFKLECOI_02632 1.9e-106 spo0B T Sporulation initiation phospho-transferase B, C-terminal
PFKLECOI_02633 2.5e-46 rpmA J Belongs to the bacterial ribosomal protein bL27 family
PFKLECOI_02634 4.1e-56 ysxB J ribosomal protein
PFKLECOI_02635 5.8e-49 rplU J This protein binds to 23S rRNA in the presence of protein L20
PFKLECOI_02636 5.9e-160 spoIVFB S Stage IV sporulation protein
PFKLECOI_02637 1.9e-144 spoIVFA M COG0739 Membrane proteins related to metalloendopeptidases
PFKLECOI_02638 2.5e-144 minD D Belongs to the ParA family
PFKLECOI_02639 1.4e-108 minC D Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization
PFKLECOI_02640 1.4e-84 mreD M shape-determining protein
PFKLECOI_02641 2.8e-157 mreC M Involved in formation and maintenance of cell shape
PFKLECOI_02642 1.8e-184 mreB D Rod shape-determining protein MreB
PFKLECOI_02643 4.8e-126 radC E Belongs to the UPF0758 family
PFKLECOI_02644 2.8e-102 maf D septum formation protein Maf
PFKLECOI_02645 2.4e-165 spoIIB S Sporulation related domain
PFKLECOI_02646 6.6e-85 comC 3.4.23.43 NOU COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases
PFKLECOI_02647 4.3e-247 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
PFKLECOI_02648 0.0 valS 6.1.1.9 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
PFKLECOI_02649 1.6e-25
PFKLECOI_02650 1.6e-199 ysxE S A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PFKLECOI_02651 1.9e-226 spoVID M stage VI sporulation protein D
PFKLECOI_02652 7.3e-247 hemL 5.4.3.8 H Glutamate-1-semialdehyde aminotransferase
PFKLECOI_02653 6.2e-182 hemB 4.2.1.24 H Belongs to the ALAD family
PFKLECOI_02654 2.4e-144 hemD 2.1.1.107, 4.2.1.75 H Uroporphyrinogen-III synthase
PFKLECOI_02655 1.5e-172 hemC 2.1.1.107, 2.5.1.61, 4.2.1.75 H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
PFKLECOI_02656 3.6e-146 hemX O cytochrome C
PFKLECOI_02657 6.6e-246 hemA 1.2.1.70 H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PFKLECOI_02658 1.4e-89 ysxD
PFKLECOI_02659 1.2e-106 engB D Necessary for normal cell division and for the maintenance of normal septation
PFKLECOI_02660 0.0 lon 3.4.21.53 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PFKLECOI_02661 2.3e-311 lonB 2.7.7.7, 3.4.21.53 LO Belongs to the peptidase S16 family
PFKLECOI_02662 3.4e-233 clpX O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PFKLECOI_02663 8.3e-227 tig D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
PFKLECOI_02664 5.1e-187 ysoA H Tetratricopeptide repeat
PFKLECOI_02665 2.6e-114 leuD 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PFKLECOI_02666 1.4e-275 leuC 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PFKLECOI_02667 3.3e-200 leuB 1.1.1.85 CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
PFKLECOI_02668 4.2e-289 leuA 2.3.3.13 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PFKLECOI_02669 3.1e-192 ilvC 1.1.1.86 EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PFKLECOI_02670 3.2e-84 ilvN 2.2.1.6 E Acetolactate synthase
PFKLECOI_02671 0.0 ilvB 2.2.1.6 E Acetolactate synthase
PFKLECOI_02673 2.3e-78 ysnE K acetyltransferase
PFKLECOI_02674 5.1e-131 G Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
PFKLECOI_02675 2e-133 ysnF S protein conserved in bacteria
PFKLECOI_02677 1.4e-92 ysnB S Phosphoesterase
PFKLECOI_02678 2.2e-102 rdgB 3.6.1.66 F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PFKLECOI_02679 1.8e-133 rph 2.7.7.56, 3.6.1.66 J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PFKLECOI_02680 4.2e-195 gerM S COG5401 Spore germination protein
PFKLECOI_02681 4.3e-152 murI 3.6.1.66, 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
PFKLECOI_02682 1.1e-74 ysmB 2.4.2.28 K helix_turn_helix multiple antibiotic resistance protein
PFKLECOI_02683 3.3e-30 gerE K Transcriptional regulator
PFKLECOI_02684 6.5e-78 ybgC 3.1.2.23, 3.1.2.28 S thioesterase
PFKLECOI_02685 4.6e-148 sdhB 1.3.5.1, 1.3.5.4 C succinate dehydrogenase
PFKLECOI_02686 0.0 sdhA 1.3.5.1, 1.3.5.4 C succinate dehydrogenase
PFKLECOI_02687 2.4e-107 sdhC C succinate dehydrogenase
PFKLECOI_02688 2e-79 yslB S Protein of unknown function (DUF2507)
PFKLECOI_02689 1.3e-216 lysC 1.1.1.3, 2.7.2.4 E Belongs to the aspartokinase family
PFKLECOI_02690 0.0 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
PFKLECOI_02691 2e-52 trxA O Belongs to the thioredoxin family
PFKLECOI_02692 7.8e-301 xsa 3.2.1.55 GH51 G Alpha-L-arabinofuranosidase C-terminus
PFKLECOI_02694 7.9e-177 etfA C Electron transfer flavoprotein
PFKLECOI_02695 4.5e-135 etfB C Electron transfer flavoprotein
PFKLECOI_02696 2.9e-134 fadB 4.2.1.17 I Belongs to the enoyl-CoA hydratase isomerase family
PFKLECOI_02697 2.7e-100 fadR K Transcriptional regulator
PFKLECOI_02698 0.0 lcfA 6.2.1.3 IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
PFKLECOI_02699 7.3e-68 yshE S membrane
PFKLECOI_02700 0.0 mutS2 L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
PFKLECOI_02701 0.0 polX L COG1796 DNA polymerase IV (family X)
PFKLECOI_02702 1.7e-85 cvpA S membrane protein, required for colicin V production
PFKLECOI_02703 2.4e-40 zapA D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
PFKLECOI_02704 1.2e-166 rnhC 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PFKLECOI_02705 0.0 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
PFKLECOI_02706 8e-196 pheS 6.1.1.20 J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PFKLECOI_02707 3.1e-133 spoU 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PFKLECOI_02708 2.6e-32 sspI S Belongs to the SspI family
PFKLECOI_02709 4.4e-208 ysfB KT regulator
PFKLECOI_02710 1.6e-263 glcD 1.1.3.15 C Glycolate oxidase subunit
PFKLECOI_02711 8.9e-256 glcF C Glycolate oxidase
PFKLECOI_02712 2.8e-53 ysfE 4.4.1.5 E Glyoxalase-like domain
PFKLECOI_02713 0.0 cstA T Carbon starvation protein
PFKLECOI_02714 1e-300 abfA 3.2.1.55 GH51 G alpha-L-arabinofuranosidase activity
PFKLECOI_02715 2.2e-143 araQ G transport system permease
PFKLECOI_02716 4.2e-167 araP G carbohydrate transport
PFKLECOI_02717 8.1e-254 araN G carbohydrate transport
PFKLECOI_02718 3.5e-219 egsA 1.1.1.261 I Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is probably used for the synthesis of phosphoglycerolipids in Gram-positive bacterial species
PFKLECOI_02719 2e-146 araL 3.1.3.41 G Haloacid dehalogenase-like hydrolase
PFKLECOI_02720 8.4e-133 araD 4.1.2.17, 4.2.1.109, 5.1.3.4 G COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases
PFKLECOI_02721 0.0 araB 2.7.1.16 C Belongs to the ribulokinase family
PFKLECOI_02722 1.9e-294 araA 5.3.1.4 G Catalyzes the conversion of L-arabinose to L-ribulose
PFKLECOI_02723 1.2e-188 abnA 3.2.1.99 GH43 G Belongs to the glycosyl hydrolase 43 family
PFKLECOI_02724 4.5e-205 ysdC G COG1363 Cellulase M and related proteins
PFKLECOI_02725 3.5e-67 ysdB S Sigma-w pathway protein YsdB
PFKLECOI_02726 7.5e-45 ysdA S Membrane
PFKLECOI_02727 3.6e-58 rplT J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PFKLECOI_02728 9e-27 rpmI J Belongs to the bacterial ribosomal protein bL35 family
PFKLECOI_02729 3.3e-86 infC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PFKLECOI_02731 2.4e-111 lrgB M Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses
PFKLECOI_02732 1.1e-48 lrgA S Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses
PFKLECOI_02733 5.4e-130 lytT T COG3279 Response regulator of the LytR AlgR family
PFKLECOI_02734 0.0 lytS 2.7.13.3 T Histidine kinase
PFKLECOI_02735 4.7e-148 ysaA S HAD-hyrolase-like
PFKLECOI_02736 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PFKLECOI_02738 1e-156 ytxC S YtxC-like family
PFKLECOI_02739 4.9e-111 ytxB S SNARE associated Golgi protein
PFKLECOI_02740 3e-173 dnaI L Primosomal protein DnaI
PFKLECOI_02741 1.5e-264 dnaB L Membrane attachment protein
PFKLECOI_02742 1.1e-80 nrdR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PFKLECOI_02743 2e-67 speH 4.1.1.50 E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
PFKLECOI_02744 2.8e-193 gapB 1.2.1.12, 1.2.1.59 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
PFKLECOI_02745 9.9e-67 ytcD K Transcriptional regulator
PFKLECOI_02746 2.1e-200 ytbD EGP Major facilitator Superfamily
PFKLECOI_02747 5.8e-160 ytbE S reductase
PFKLECOI_02748 5.4e-96 coaE 2.7.1.24 F Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
PFKLECOI_02749 1.1e-107 ytaF P Probably functions as a manganese efflux pump
PFKLECOI_02750 7.8e-157 fpg 3.2.2.23, 4.2.99.18 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
PFKLECOI_02751 0.0 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PFKLECOI_02752 0.0 phoR 2.7.13.3 T Signal transduction histidine kinase
PFKLECOI_02753 2.2e-131 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
PFKLECOI_02754 3.1e-170 mdh 1.1.1.37 C Catalyzes the reversible oxidation of malate to oxaloacetate
PFKLECOI_02755 4.1e-242 icd 1.1.1.42 C isocitrate
PFKLECOI_02756 4.7e-210 citZ 2.3.3.1 C Belongs to the citrate synthase family
PFKLECOI_02757 2.3e-70 yeaL S membrane
PFKLECOI_02758 9.9e-192 ytvI S sporulation integral membrane protein YtvI
PFKLECOI_02759 8.7e-63 fxsA S COG3030 Protein affecting phage T7 exclusion by the F plasmid
PFKLECOI_02760 0.0 pyk 2.7.1.40, 2.7.7.4 G Belongs to the pyruvate kinase family
PFKLECOI_02761 1.3e-179 pfkA 2.7.1.11 F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
PFKLECOI_02762 4.3e-183 accA 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
PFKLECOI_02763 8.4e-162 accD 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PFKLECOI_02764 1.5e-225 ytsJ 1.1.1.38 C Malate dehydrogenase
PFKLECOI_02765 0.0 dnaE 2.7.7.7 L DNA polymerase
PFKLECOI_02766 3.2e-56 ytrH S Sporulation protein YtrH
PFKLECOI_02767 8.2e-69 ytrI
PFKLECOI_02768 9.2e-29
PFKLECOI_02769 7.8e-182 nrnA 3.1.13.3, 3.1.3.7 S COG0618 Exopolyphosphatase-related proteins
PFKLECOI_02770 2.4e-47 ytpI S YtpI-like protein
PFKLECOI_02771 8e-241 ytoI K transcriptional regulator containing CBS domains
PFKLECOI_02772 9.9e-158 ytnM S membrane transporter protein
PFKLECOI_02773 1e-237 ytnL 3.5.1.47 E hydrolase activity
PFKLECOI_02774 9e-127 ribF 2.7.1.26, 2.7.7.2 H Riboflavin kinase
PFKLECOI_02775 3.5e-252 moxC C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PFKLECOI_02776 6e-45 ytnI O COG0695 Glutaredoxin and related proteins
PFKLECOI_02777 2.6e-183 ytmO C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PFKLECOI_02778 3.9e-142 tcyN 3.6.3.21 E COG1126 ABC-type polar amino acid transport system, ATPase component
PFKLECOI_02779 9.3e-119 tcyM U Binding-protein-dependent transport system inner membrane component
PFKLECOI_02780 3.7e-123 tcyL P Binding-protein-dependent transport system inner membrane component
PFKLECOI_02781 6.4e-148 tcyK M Bacterial periplasmic substrate-binding proteins
PFKLECOI_02782 2.1e-151 tcyK ET Bacterial periplasmic substrate-binding proteins
PFKLECOI_02783 4.3e-100 ytmI K Acetyltransferase (GNAT) domain
PFKLECOI_02784 1.2e-171 ytlI K LysR substrate binding domain
PFKLECOI_02785 1.7e-130 ytkL S Belongs to the UPF0173 family
PFKLECOI_02786 2.5e-141 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
PFKLECOI_02788 4.4e-266 argH 4.3.2.1 E argininosuccinate lyase
PFKLECOI_02789 2.3e-234 argG 6.3.4.5 E Belongs to the argininosuccinate synthase family. Type 1 subfamily
PFKLECOI_02790 3.6e-88 moaB 2.7.7.75 H May be involved in the biosynthesis of molybdopterin
PFKLECOI_02791 3.7e-221 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
PFKLECOI_02792 5.9e-164 ytxK 2.1.1.72 L DNA methylase
PFKLECOI_02793 7.1e-89 tpx 1.11.1.15 O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
PFKLECOI_02794 2.3e-70 ytfJ S Sporulation protein YtfJ
PFKLECOI_02795 1.6e-115 ytfI S Protein of unknown function (DUF2953)
PFKLECOI_02796 2.5e-86 yteJ S RDD family
PFKLECOI_02797 8.7e-179 sppA OU signal peptide peptidase SppA
PFKLECOI_02798 6.3e-148 nadK 2.7.1.23 G Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PFKLECOI_02799 0.0 ytcJ S amidohydrolase
PFKLECOI_02800 1.7e-306 acsA 6.2.1.1, 6.2.1.2 I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases
PFKLECOI_02801 2e-29 sspB S spore protein
PFKLECOI_02802 3.5e-227 thiI 2.8.1.4 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PFKLECOI_02803 1.2e-208 iscS2 2.8.1.7 E Cysteine desulfurase
PFKLECOI_02804 1.4e-237 brnQ E Component of the transport system for branched-chain amino acids
PFKLECOI_02805 7.8e-273 ezrA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
PFKLECOI_02806 3.5e-154 hisK 3.1.3.15 E COG1387 Histidinol phosphatase and related hydrolases of the PHP family
PFKLECOI_02807 3.4e-109 yttP K Transcriptional regulator
PFKLECOI_02808 1.2e-88 ytsP 1.8.4.14 T GAF domain-containing protein
PFKLECOI_02809 2.4e-311 ytrP 2.7.7.65 T COG2199 FOG GGDEF domain
PFKLECOI_02810 2.5e-109 rpsD J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PFKLECOI_02812 2.3e-237 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PFKLECOI_02813 0.0 acsA 6.2.1.1 I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases
PFKLECOI_02814 3.6e-122 acuA K Part of the acuABC operon, which is possibly involved in the breakdown of acetoin and butanediol. Acts as an acetyltransferase inactivating acetyl-CoA synthetase AcsA via acetylation at a Lys residue
PFKLECOI_02815 1.6e-117 acuB S Domain in cystathionine beta-synthase and other proteins.
PFKLECOI_02816 5.4e-225 acuC BQ histone deacetylase
PFKLECOI_02817 1.4e-125 motS N Flagellar motor protein
PFKLECOI_02818 2.1e-146 motA N flagellar motor
PFKLECOI_02819 1.7e-182 ccpA K catabolite control protein A
PFKLECOI_02820 4.9e-196 aroF 2.5.1.54, 5.4.99.5 E Catalyzes the formation of 3-deoxy-D-aribino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate and the formation of prephenate from chorismate
PFKLECOI_02821 4.8e-54 ytxJ O Protein of unknown function (DUF2847)
PFKLECOI_02822 6.6e-17 ytxH S COG4980 Gas vesicle protein
PFKLECOI_02823 2.1e-17 ytxG S protein containing a divergent version of the methyl-accepting chemotaxis-like domain
PFKLECOI_02824 1.6e-254 mpl 6.3.2.4, 6.3.2.45, 6.3.2.8 M Belongs to the MurCDEF family
PFKLECOI_02825 0.0 sftA D Belongs to the FtsK SpoIIIE SftA family
PFKLECOI_02826 1.4e-107 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
PFKLECOI_02827 9.8e-149 ytpQ S Belongs to the UPF0354 family
PFKLECOI_02828 2.1e-57 ytpP 2.7.1.180, 5.3.4.1 CO Thioredoxin
PFKLECOI_02829 5.9e-79 ytoQ S Nucleoside 2-deoxyribosyltransferase YtoQ
PFKLECOI_02830 6.8e-206 pepA 3.4.11.7 G COG1363 Cellulase M and related proteins
PFKLECOI_02831 1.1e-50 ytzB S small secreted protein
PFKLECOI_02832 0.0 sfcA 1.1.1.38 C Malate dehydrogenase
PFKLECOI_02833 6e-149 ytnP S COG0491 Zn-dependent hydrolases, including glyoxylases
PFKLECOI_02834 1.4e-121 trmB 2.1.1.297, 2.1.1.33 J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
PFKLECOI_02835 2e-45 ytzH S YtzH-like protein
PFKLECOI_02836 6.1e-151 ytmP 2.7.1.89 M Phosphotransferase
PFKLECOI_02837 0.0 pulA 3.2.1.41 CBM48,GH13 G Belongs to the glycosyl hydrolase 13 family
PFKLECOI_02838 2.9e-181 ytlR 2.7.1.91 I Diacylglycerol kinase catalytic domain
PFKLECOI_02839 1.3e-165 ytlQ
PFKLECOI_02840 2.6e-100 ligT 3.1.4.58, 3.5.1.42 J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
PFKLECOI_02841 8.6e-173 ytkP 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
PFKLECOI_02842 2.3e-270 pepV 3.5.1.18 E Dipeptidase
PFKLECOI_02843 2.1e-225 pbuO S permease
PFKLECOI_02844 4.6e-200 ythQ U Bacterial ABC transporter protein EcsB
PFKLECOI_02845 4.8e-131 ythP V ABC transporter
PFKLECOI_02846 2.4e-33 ytzE K COG1349 Transcriptional regulators of sugar metabolism
PFKLECOI_02847 4.8e-131 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
PFKLECOI_02848 3.6e-280 ytgP S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
PFKLECOI_02849 8.2e-232 ytfP S HI0933-like protein
PFKLECOI_02850 1.3e-282 opuD M Belongs to the BCCT transporter (TC 2.A.15) family
PFKLECOI_02851 3.1e-26 yteV S Sporulation protein Cse60
PFKLECOI_02852 5.9e-115 yteU S Integral membrane protein
PFKLECOI_02853 3e-256 yteT S Oxidoreductase family, C-terminal alpha/beta domain
PFKLECOI_02854 3e-72 yteS G transport
PFKLECOI_02855 5.2e-217 yteR 3.2.1.172 GH105 G unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins
PFKLECOI_02856 1.1e-170 lplB G COG4209 ABC-type polysaccharide transport system, permease component
PFKLECOI_02857 0.0 ytdP K Transcriptional regulator
PFKLECOI_02858 1.2e-288 ytcQ G COG1653 ABC-type sugar transport system, periplasmic component
PFKLECOI_02859 1.5e-150 ytcP G COG0395 ABC-type sugar transport system, permease component
PFKLECOI_02860 9.6e-138 udh 1.1.1.203, 1.1.1.388 GM NAD dependent epimerase/dehydratase family
PFKLECOI_02861 2.7e-224 bioI 1.14.14.46 C Cytochrome P450
PFKLECOI_02862 8.4e-190 bioB 2.8.1.6 H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PFKLECOI_02863 4.2e-124 bioD 6.3.3.3 H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
PFKLECOI_02864 1.8e-215 bioF 2.3.1.29, 2.3.1.47, 6.2.1.14 H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide
PFKLECOI_02865 3e-259 bioA 2.6.1.105, 2.6.1.62 H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor
PFKLECOI_02866 3.2e-149 bioW 2.3.1.47, 6.2.1.14 H Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
PFKLECOI_02867 7.8e-171 ytaP S Acetyl xylan esterase (AXE1)
PFKLECOI_02868 6.6e-190 msmR K Transcriptional regulator
PFKLECOI_02869 2.8e-246 msmE G Bacterial extracellular solute-binding protein
PFKLECOI_02870 1.4e-167 amyD P ABC transporter
PFKLECOI_02871 3.7e-143 amyC P ABC transporter (permease)
PFKLECOI_02872 4e-253 melA 3.2.1.122, 3.2.1.22, 3.2.1.86 GH4,GT4 G Family 4 glycosyl hydrolase
PFKLECOI_02873 2.1e-51 ytwF P Sulfurtransferase
PFKLECOI_02874 0.0 leuS 6.1.1.4 J Belongs to the class-I aminoacyl-tRNA synthetase family
PFKLECOI_02875 7.7e-55 ytvB S Protein of unknown function (DUF4257)
PFKLECOI_02876 3.9e-142 pfyP T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)
PFKLECOI_02877 1.7e-210 yttB EGP Major facilitator Superfamily
PFKLECOI_02878 3.9e-43 yttA 2.7.13.3 S Pfam Transposase IS66
PFKLECOI_02879 0.0 bceB V ABC transporter (permease)
PFKLECOI_02880 1.1e-138 bceA V ABC transporter, ATP-binding protein
PFKLECOI_02881 1.2e-185 T PhoQ Sensor
PFKLECOI_02882 2.6e-129 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
PFKLECOI_02883 5.5e-234 ytrF V COG0577 ABC-type antimicrobial peptide transport system, permease component
PFKLECOI_02884 3.1e-127 ytrE V ABC transporter, ATP-binding protein
PFKLECOI_02885 9.8e-127
PFKLECOI_02886 1.2e-145 P ABC-2 family transporter protein
PFKLECOI_02887 4.6e-160 ytrB P abc transporter atp-binding protein
PFKLECOI_02888 5.1e-66 ytrA K GntR family transcriptional regulator
PFKLECOI_02890 6.7e-41 ytzC S Protein of unknown function (DUF2524)
PFKLECOI_02891 8.1e-190 yhcC S Fe-S oxidoreductase
PFKLECOI_02892 2.2e-105 ytqB J Putative rRNA methylase
PFKLECOI_02893 2.8e-215 ytpB 4.2.3.130 S Tetraprenyl-beta-curcumene synthase
PFKLECOI_02894 3.3e-149 ytpA 3.1.1.5 I Alpha beta hydrolase
PFKLECOI_02895 1.6e-59 ytoA S COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
PFKLECOI_02896 8.4e-257 ytnA E COG1113 Gamma-aminobutyrate permease and related permeases
PFKLECOI_02897 0.0 asnB 6.3.5.4 E Asparagine synthase
PFKLECOI_02898 4.3e-225 metK 2.5.1.6 H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PFKLECOI_02899 2.6e-310 pckA 4.1.1.49 C Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
PFKLECOI_02900 1.2e-38 ytmB S Protein of unknown function (DUF2584)
PFKLECOI_02901 1.6e-148 ytmA E COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases
PFKLECOI_02902 4e-187 ytlA P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components
PFKLECOI_02903 1.4e-144 ytlC P ABC transporter
PFKLECOI_02904 6.8e-142 ytlD P COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component
PFKLECOI_02905 2.8e-87 ytkD 3.6.1.55 L Belongs to the Nudix hydrolase family
PFKLECOI_02906 5.4e-63 ytkC S Bacteriophage holin family
PFKLECOI_02907 2.1e-76 dps P Belongs to the Dps family
PFKLECOI_02909 5.3e-72 ytkA S YtkA-like
PFKLECOI_02910 4.8e-87 luxS 4.4.1.21 T Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
PFKLECOI_02911 5.7e-103 ytiB 4.2.1.1 P Reversible hydration of carbon dioxide
PFKLECOI_02912 3.6e-41 rpmE2 J Ribosomal protein L31
PFKLECOI_02913 1.1e-248 cydA 1.10.3.14 C oxidase, subunit
PFKLECOI_02914 1.8e-187 cydB 1.10.3.14 C COG1294 Cytochrome bd-type quinol oxidase, subunit 2
PFKLECOI_02915 1.1e-24 S Domain of Unknown Function (DUF1540)
PFKLECOI_02916 9.7e-150 troD P 'COG1108 ABC-type Mn2 Zn2 transport systems, permease components'
PFKLECOI_02917 3.3e-231 mntC P COG1108 ABC-type Mn2 Zn2 transport systems, permease components
PFKLECOI_02918 8.6e-139 mntB P 'COG1121 ABC-type Mn Zn transport systems, ATPase component'
PFKLECOI_02919 6.7e-170 troA P Belongs to the bacterial solute-binding protein 9 family
PFKLECOI_02920 1.2e-213 menC 4.2.1.113 H Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)
PFKLECOI_02921 8.8e-273 menE 6.2.1.26 H Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily
PFKLECOI_02922 4.2e-155 menB 4.1.3.36 H Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
PFKLECOI_02923 3.3e-152 menH 4.2.99.20 S Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC)
PFKLECOI_02924 0.0 menD 2.2.1.9 H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
PFKLECOI_02925 1.9e-272 menF 5.4.4.2 HQ Isochorismate synthase
PFKLECOI_02926 5.7e-132 dksA T COG1734 DnaK suppressor protein
PFKLECOI_02927 1e-153 galU 2.7.7.9 M Nucleotidyl transferase
PFKLECOI_02928 1.5e-244 ugd 1.1.1.22 M Belongs to the UDP-glucose GDP-mannose dehydrogenase family
PFKLECOI_02929 1.1e-180 ytcB 5.1.3.2 M NAD-dependent epimerase dehydratase
PFKLECOI_02930 1.4e-234 ytcC M Glycosyltransferase Family 4
PFKLECOI_02932 2.3e-206 cotS S Seems to be required for the assembly of the CotSA protein in spores
PFKLECOI_02933 6.9e-217 cotSA M Glycosyl transferases group 1
PFKLECOI_02934 1.1e-205 cotI S Spore coat protein
PFKLECOI_02935 1.3e-76 tspO T membrane
PFKLECOI_02936 0.0 glgP 2.4.1.1 GT35 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
PFKLECOI_02937 7.6e-285 glgA 2.4.1.21 GT5 G Synthesizes alpha-1,4-glucan chains using ADP-glucose
PFKLECOI_02938 1.4e-176 glgD 2.4.1.21, 2.7.7.27 GT5 G Glucose-1-phosphate adenylyltransferase, GlgD subunit
PFKLECOI_02939 6.1e-197 glgC 2.7.7.27 G Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
PFKLECOI_02940 0.0 glgB 2.4.1.18, 3.2.1.141, 3.2.1.20 CBM48,GH13,GH31 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
PFKLECOI_02942 1.5e-15 fliC N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PFKLECOI_02943 7.8e-52 flaG N flagellar protein FlaG
PFKLECOI_02944 2.2e-247 fliD N morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
PFKLECOI_02945 2.9e-69 fliS N flagellar protein FliS
PFKLECOI_02946 1.9e-08 fliT S bacterial-type flagellum organization
PFKLECOI_02947 3e-50
PFKLECOI_02948 2.2e-102 hpf J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
PFKLECOI_02949 0.0 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
PFKLECOI_02950 1.8e-184 prfB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
PFKLECOI_02951 5.5e-142 yvjA S Uncharacterized protein conserved in bacteria (DUF2179)
PFKLECOI_02952 4.5e-55 cccB C COG2010 Cytochrome c, mono- and diheme variants
PFKLECOI_02953 6e-123 ftsE D cell division ATP-binding protein FtsE
PFKLECOI_02954 2.1e-155 ftsX D Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation
PFKLECOI_02955 7.6e-269 ctpB 3.4.21.102 M Belongs to the peptidase S41A family
PFKLECOI_02956 5.3e-56 swrA S Swarming motility protein
PFKLECOI_02957 1.9e-220 minJ O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PFKLECOI_02958 5.6e-226 yvkA EGP Major facilitator Superfamily
PFKLECOI_02959 2e-100 yvkB K Transcriptional regulator
PFKLECOI_02960 0.0 yvkC 2.7.9.2 GT Phosphotransferase
PFKLECOI_02961 1.2e-30 csbA S protein conserved in bacteria
PFKLECOI_02962 0.0 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
PFKLECOI_02963 0.0 uvrA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
PFKLECOI_02964 1.2e-114 fliC N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PFKLECOI_02965 6.7e-34 yvkN
PFKLECOI_02966 8e-49 yvlA
PFKLECOI_02967 1.3e-167 yvlB S Putative adhesin
PFKLECOI_02968 2.6e-26 pspB KT PspC domain
PFKLECOI_02969 1.2e-50 yvlD S Membrane
PFKLECOI_02970 5.1e-202 yvmA EGP Major facilitator Superfamily
PFKLECOI_02971 2e-86 yvmB K helix_turn_helix multiple antibiotic resistance protein
PFKLECOI_02972 1.5e-132 yvmC 2.3.2.22 S Involved in the biosynthesis of pulcherrimin, a red extracellular pigment. It uses activated amino acids in the form of aminoacyl-tRNAs (aa-tRNAs) as substrates to catalyze the ATP- independent formation of cyclodipeptides which are intermediates in diketopiperazine (DKP) biosynthetic pathways. Catalyzes the formation of cyclo(L-Leu-L-Leu) (cLL) from L-leucyl-tRNA(Leu). Can also incorporate various nonpolar residues, such as L- phenylalanine, L-leucine and methionine, into cyclodipeptides
PFKLECOI_02973 5e-229 cypX 1.14.15.13 C Cytochrome P450
PFKLECOI_02974 4.2e-72 adcR K helix_turn_helix multiple antibiotic resistance protein
PFKLECOI_02975 0.0 yvnB 3.1.4.53 Q Calcineurin-like phosphoesterase
PFKLECOI_02976 1.8e-133 yvoA K transcriptional
PFKLECOI_02977 4.3e-127 nagB 3.1.1.31, 3.5.99.6 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
PFKLECOI_02978 2.4e-220 nagA 3.5.1.25 G Belongs to the metallo-dependent hydrolases superfamily. NagA family
PFKLECOI_02979 2.9e-168 hprK F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
PFKLECOI_02980 4.9e-148 lgt 2.1.1.199 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PFKLECOI_02981 1.7e-160 yvoD P COG0370 Fe2 transport system protein B
PFKLECOI_02982 1.2e-117 ppaX 3.1.3.18, 3.6.1.1 S Hydrolyzes pyrophosphate formed during P-Ser-HPr dephosphorylation by HPrK P. Might play a role in controlling the intracellular pyrophosphate pool
PFKLECOI_02983 1.6e-80 yvoF S COG0110 Acetyltransferase (isoleucine patch superfamily)
PFKLECOI_02984 5.1e-119 hrpW 4.2.2.10, 4.2.2.2 G Pectate lyase
PFKLECOI_02985 3.8e-139 yvpB NU protein conserved in bacteria
PFKLECOI_02986 4.5e-219 hisZ 2.4.2.17, 6.1.1.21 E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
PFKLECOI_02987 7.4e-115 hisG 2.4.2.17 E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
PFKLECOI_02988 3.8e-227 hisD 1.1.1.23, 1.1.1.308 E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PFKLECOI_02989 4.7e-108 hisB 1.1.1.23, 2.6.1.9, 3.1.3.15, 4.2.1.19 E imidazoleglycerol-phosphate dehydratase
PFKLECOI_02990 6.2e-114 hisH E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PFKLECOI_02991 1.1e-130 hisA 5.3.1.16 E 1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PFKLECOI_02992 4e-136 hisF E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
PFKLECOI_02993 2.2e-111 hisE 3.5.4.19, 3.6.1.31, 5.3.1.16 E belongs to the PRA-CH family
PFKLECOI_02994 2.2e-78
PFKLECOI_02995 1e-252
PFKLECOI_02997 0.0 msbA2 3.6.3.44 V ABC transporter
PFKLECOI_02998 1.2e-277 S COG0457 FOG TPR repeat
PFKLECOI_02999 1.1e-97 usp CBM50 M protein conserved in bacteria
PFKLECOI_03000 1.4e-175 trxB 1.8.1.9 C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
PFKLECOI_03001 3.9e-89 yvcI 3.6.1.55 F COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
PFKLECOI_03002 5.7e-166 rapZ S Displays ATPase and GTPase activities
PFKLECOI_03003 7.3e-178 ybhK S Required for morphogenesis under gluconeogenic growth conditions
PFKLECOI_03004 1.4e-170 whiA K May be required for sporulation
PFKLECOI_03005 1.6e-36 crh G Phosphocarrier protein Chr
PFKLECOI_03006 4.9e-142 nhoA 2.3.1.118 Q Belongs to the arylamine N-acetyltransferase family
PFKLECOI_03007 3.3e-32
PFKLECOI_03008 3.9e-133 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
PFKLECOI_03009 3.1e-198 yvcQ 2.7.13.3 T His Kinase A (phosphoacceptor) domain
PFKLECOI_03010 5.6e-141 yvcR V ABC transporter, ATP-binding protein
PFKLECOI_03011 0.0 yxdM V ABC transporter (permease)
PFKLECOI_03012 8.7e-184 ghrB 1.1.1.215, 1.1.1.26, 1.1.1.43, 1.1.1.79, 1.1.1.81 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PFKLECOI_03013 5.7e-106 ytiB 4.2.1.1 P Reversible hydration of carbon dioxide
PFKLECOI_03014 2.8e-288 sulP P COG0659 Sulfate permease and related transporters (MFS superfamily)
PFKLECOI_03015 2e-52 yvdC S MazG nucleotide pyrophosphohydrolase domain
PFKLECOI_03016 3.3e-106 yvdD 3.2.2.10 S Belongs to the LOG family
PFKLECOI_03017 8.8e-173 yvdE K Transcriptional regulator
PFKLECOI_03018 0.0 nplT 3.2.1.133, 3.2.1.135, 3.2.1.54 GH13 G Alpha amylase, N-terminal ig-like domain
PFKLECOI_03019 2e-233 mdxE G COG2182 Maltose-binding periplasmic proteins domains
PFKLECOI_03020 2e-244 malC P COG1175 ABC-type sugar transport systems, permease components
PFKLECOI_03021 3.9e-148 malD P transport
PFKLECOI_03022 3.8e-154 malA S Protein of unknown function (DUF1189)
PFKLECOI_03023 0.0 yvdK 2.4.1.8 GH65 G Glycoside hydrolase, family 65
PFKLECOI_03024 0.0 malL 3.2.1.10 GH13 G COG0366 Glycosidases
PFKLECOI_03025 3.9e-122 pgmB 2.4.1.64, 3.1.3.12, 3.2.1.28, 5.4.2.6 GH37,GH65 S Haloacid dehalogenase-like hydrolase
PFKLECOI_03026 1.2e-103 clpP 3.4.21.92 OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
PFKLECOI_03028 1.2e-182 S Patatin-like phospholipase
PFKLECOI_03029 8.4e-270 ygaK C COG0277 FAD FMN-containing dehydrogenases
PFKLECOI_03030 2.2e-93 yvdQ S Protein of unknown function (DUF3231)
PFKLECOI_03031 4.1e-50 sugE P Small Multidrug Resistance protein
PFKLECOI_03032 1.5e-50 ykkC P Small Multidrug Resistance protein
PFKLECOI_03033 7.4e-106 yvdT K Transcriptional regulator
PFKLECOI_03034 1.8e-295 yveA E amino acid
PFKLECOI_03035 0.0 levB 3.2.1.26, 3.2.1.64, 3.2.1.65, 3.2.1.80 GH32 G Belongs to the glycosyl hydrolase 32 family
PFKLECOI_03036 1.2e-274 sacB 2.4.1.10 GH68 M levansucrase activity
PFKLECOI_03037 2.7e-260 pbpE V Beta-lactamase
PFKLECOI_03038 1.9e-124 racX 5.1.1.13 M Belongs to the aspartate glutamate racemases family
PFKLECOI_03039 2.1e-71 MA20_18690 S Protein of unknown function (DUF3237)
PFKLECOI_03040 6.6e-92 padC Q Phenolic acid decarboxylase
PFKLECOI_03042 6.1e-282 pnbA CE10 I Belongs to the type-B carboxylesterase lipase family
PFKLECOI_03043 6.3e-76 slr K transcriptional
PFKLECOI_03044 4e-122 ywqC M biosynthesis protein
PFKLECOI_03045 1e-114 epsB 2.7.10.2 D COG0489 ATPases involved in chromosome partitioning
PFKLECOI_03046 0.0 pglF 4.2.1.115, 4.2.1.135, 4.2.1.46 GM Polysaccharide biosynthesis protein
PFKLECOI_03047 2.5e-222 epsD GT4 M Glycosyl transferase 4-like
PFKLECOI_03048 4.5e-157 epsE GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
PFKLECOI_03049 1.9e-214 epsF GT4 M Glycosyl transferases group 1
PFKLECOI_03050 2.4e-206 epsG S EpsG family
PFKLECOI_03051 4.4e-194 epsH GT2 S Glycosyltransferase like family 2
PFKLECOI_03052 2.4e-203 epsI GM pyruvyl transferase
PFKLECOI_03053 3.1e-195 epsJ GT2 S COG0463 Glycosyltransferases involved in cell wall biogenesis
PFKLECOI_03054 1e-255 pglK S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
PFKLECOI_03055 5.4e-107 epsL M COG2148 Sugar transferases involved in lipopolysaccharide synthesis
PFKLECOI_03056 2.1e-56 epsM GM COG0110 Acetyltransferase (isoleucine patch superfamily)
PFKLECOI_03057 2.9e-218 epsN 2.6.1.102 E Belongs to the DegT DnrJ EryC1 family
PFKLECOI_03058 8.3e-187 yvfF GM Exopolysaccharide biosynthesis protein
PFKLECOI_03059 1e-31 yvfG S YvfG protein
PFKLECOI_03060 1.4e-240 rpoN K COG1508 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog
PFKLECOI_03061 6.3e-307 yvfH C L-lactate permease
PFKLECOI_03062 1e-112 yvfI K COG2186 Transcriptional regulators
PFKLECOI_03063 1.2e-183 lacR K Transcriptional regulator
PFKLECOI_03064 2.9e-224 cycB G COG2182 Maltose-binding periplasmic proteins domains
PFKLECOI_03065 5.5e-231 malC P COG1175 ABC-type sugar transport systems, permease components
PFKLECOI_03066 7.2e-150 ganQ P transport
PFKLECOI_03067 0.0 lacA 3.2.1.23 G beta-galactosidase
PFKLECOI_03068 1e-248 galA 3.2.1.89 G arabinogalactan
PFKLECOI_03069 5.9e-198 rsbU 3.1.3.3 T response regulator
PFKLECOI_03070 9.8e-157 rsbQ S Alpha/beta hydrolase family
PFKLECOI_03071 1.9e-161 yvfR V COG1131 ABC-type multidrug transport system, ATPase component
PFKLECOI_03072 1.1e-133 yvfS V COG0842 ABC-type multidrug transport system, permease component
PFKLECOI_03073 2.1e-197 desK 2.7.13.3 T Histidine kinase
PFKLECOI_03074 3.8e-105 desR T COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
PFKLECOI_03075 1.5e-137 lutA C Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source
PFKLECOI_03076 7.8e-274 lutB C Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source. Has probably a role as an electron transporter during oxidation of L-lactate
PFKLECOI_03077 2.3e-133 lutC S Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source
PFKLECOI_03078 2.9e-193 yvbX S Glycosyl hydrolase
PFKLECOI_03079 2.8e-241 yvbW E COG1113 Gamma-aminobutyrate permease and related permeases
PFKLECOI_03080 2.1e-155 yvbV EG EamA-like transporter family
PFKLECOI_03081 3.6e-157 yvbU K Transcriptional regulator
PFKLECOI_03083 1.5e-191 yvbT C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PFKLECOI_03084 5.5e-203 araR K transcriptional
PFKLECOI_03085 1.6e-252 araE EGP Major facilitator Superfamily
PFKLECOI_03086 2.6e-183 cggR K COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain
PFKLECOI_03087 6.2e-185 gapA 1.2.1.12 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
PFKLECOI_03088 1e-218 pgk 2.7.2.3, 5.3.1.1 F Belongs to the phosphoglycerate kinase family
PFKLECOI_03089 4.3e-138 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
PFKLECOI_03090 1.3e-298 gpmI 5.4.2.12 G Catalyzes the interconversion of 2-phosphoglycerate and
PFKLECOI_03091 8.4e-243 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
PFKLECOI_03092 7.7e-82 yvbK 3.1.3.25 K acetyltransferase
PFKLECOI_03093 0.0 tcaA S response to antibiotic
PFKLECOI_03094 3.6e-123 exoY M Membrane
PFKLECOI_03095 8.6e-113 yvbH S YvbH-like oligomerisation region
PFKLECOI_03096 1.9e-102 yvbG U UPF0056 membrane protein
PFKLECOI_03097 1.4e-98 yvbF K Belongs to the GbsR family
PFKLECOI_03098 8.8e-212 opuCA 3.6.3.32 E COG1125 ABC-type proline glycine betaine transport systems, ATPase components
PFKLECOI_03099 4.5e-112 opuCB P COG1174 ABC-type proline glycine betaine transport systems, permease component
PFKLECOI_03100 7.9e-171 opuCC M COG1732 Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
PFKLECOI_03101 1.1e-105 opuCD P COG1174 ABC-type proline glycine betaine transport systems, permease component
PFKLECOI_03102 3.3e-60 yvbF K Belongs to the GbsR family
PFKLECOI_03103 1.2e-211 opuCA 3.6.3.32 E COG1125 ABC-type proline glycine betaine transport systems, ATPase components
PFKLECOI_03104 2.5e-110 opuCB P COG1174 ABC-type proline glycine betaine transport systems, permease component
PFKLECOI_03105 2.1e-171 opuCC M COG1732 Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
PFKLECOI_03106 8.1e-112 opuCD P COG1174 ABC-type proline glycine betaine transport systems, permease component
PFKLECOI_03107 1.8e-224 NT chemotaxis protein
PFKLECOI_03108 2.2e-54 yodB K transcriptional
PFKLECOI_03109 5.2e-69 yvaO K Cro/C1-type HTH DNA-binding domain
PFKLECOI_03110 4e-69 K transcriptional
PFKLECOI_03111 7.5e-36 yvzC K Transcriptional
PFKLECOI_03112 3.4e-151 yvaM S Serine aminopeptidase, S33
PFKLECOI_03113 2.4e-23 secG U Preprotein translocase subunit SecG
PFKLECOI_03114 5.6e-143 est 3.1.1.1 S Carboxylesterase
PFKLECOI_03115 0.0 rnr K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
PFKLECOI_03116 1.6e-82 smpB O Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PFKLECOI_03118 9.1e-131 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
PFKLECOI_03119 1.5e-98 K Bacterial regulatory proteins, tetR family
PFKLECOI_03120 2.4e-54 yvaE P Small Multidrug Resistance protein
PFKLECOI_03121 1.3e-72 yvaD S Family of unknown function (DUF5360)
PFKLECOI_03122 0.0 yvaC S Fusaric acid resistance protein-like
PFKLECOI_03123 2.4e-118 azoR I Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PFKLECOI_03124 1.2e-194 yvaA 1.1.1.371 S Oxidoreductase
PFKLECOI_03125 2.2e-48 csoR S transcriptional
PFKLECOI_03126 1.5e-29 copZ P Copper resistance protein CopZ
PFKLECOI_03127 0.0 copA 3.6.3.54 P P-type ATPase
PFKLECOI_03128 0.0 cadA 3.6.3.3, 3.6.3.5 P COG2217 Cation transport ATPase
PFKLECOI_03129 1.6e-104 bdbD O Thioredoxin
PFKLECOI_03130 2.2e-72 bdbC O Required for disulfide bond formation in some proteins
PFKLECOI_03131 4.1e-107 yvgT S membrane
PFKLECOI_03132 0.0 helD 3.6.4.12 L DNA helicase
PFKLECOI_03133 0.0 cysJ 1.8.1.2 P Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PFKLECOI_03134 0.0 cysI 1.7.7.1, 1.8.1.2, 1.8.7.1 P Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate
PFKLECOI_03135 0.0 yjcE P COG0025 NhaP-type Na H and K H antiporters
PFKLECOI_03136 1.2e-85 yvgO
PFKLECOI_03137 5.9e-157 yvgN S reductase
PFKLECOI_03138 1.3e-117 modB P COG4149 ABC-type molybdate transport system, permease component
PFKLECOI_03139 1.2e-135 modA P COG0725 ABC-type molybdate transport system, periplasmic component
PFKLECOI_03140 2.4e-167 yvgK P COG1910 Periplasmic molybdate-binding protein domain
PFKLECOI_03141 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
PFKLECOI_03142 1e-84 yvsG S LexA-binding, inner membrane-associated putative hydrolase
PFKLECOI_03143 6.5e-16 S Small spore protein J (Spore_SspJ)
PFKLECOI_03144 1.4e-235 yvsH E Arginine ornithine antiporter
PFKLECOI_03146 6.9e-178 fhuD P ABC transporter
PFKLECOI_03147 2.3e-182 fhuB P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PFKLECOI_03148 5.3e-176 fhuG P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PFKLECOI_03149 1.7e-148 fhuC 3.6.3.34 HP ABC transporter
PFKLECOI_03150 2e-174 M Efflux transporter rnd family, mfp subunit
PFKLECOI_03151 1.6e-123 macB V ABC transporter, ATP-binding protein
PFKLECOI_03152 2.6e-209 yvrN V COG0577 ABC-type antimicrobial peptide transport system, permease component
PFKLECOI_03153 4.9e-64 yvrL S Regulatory protein YrvL
PFKLECOI_03154 1.8e-228 oxdC 4.1.1.2 G Oxalate decarboxylase
PFKLECOI_03155 2.4e-19 S YvrJ protein family
PFKLECOI_03156 9.5e-98 yvrI K RNA polymerase
PFKLECOI_03157 7.2e-23
PFKLECOI_03158 2.8e-131 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
PFKLECOI_03159 0.0 T PhoQ Sensor
PFKLECOI_03160 4.5e-171 yvrE G SMP-30/Gluconolaconase/LRE-like region
PFKLECOI_03161 1.5e-138 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
PFKLECOI_03162 2.9e-168 yvrC P COG0614 ABC-type Fe3 -hydroxamate transport system, periplasmic component
PFKLECOI_03163 2.7e-183 btuC P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PFKLECOI_03164 6e-244 yvrA 3.6.3.34 HP COG1120 ABC-type cobalamin Fe3 -siderophores transport systems, ATPase components
PFKLECOI_03165 6.5e-102 yvqK 2.5.1.17 S Adenosyltransferase
PFKLECOI_03166 7e-226 yvqJ EGP Major facilitator Superfamily
PFKLECOI_03167 9.6e-62 liaI S membrane
PFKLECOI_03168 1.4e-103 liaH KT COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription
PFKLECOI_03169 2.3e-127 liaG S Putative adhesin
PFKLECOI_03170 9.5e-127 yvqF S Cell wall-active antibiotics response 4TMS YvqF
PFKLECOI_03171 1.6e-186 vraS 2.7.13.3 T Histidine kinase
PFKLECOI_03172 3e-108 vraR KT COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
PFKLECOI_03173 3.6e-181 gerAC S Spore germination B3/ GerAC like, C-terminal
PFKLECOI_03174 1.3e-196 gerAB E Spore germination protein
PFKLECOI_03175 5.9e-245 gerAA EG Spore germination protein
PFKLECOI_03176 2.3e-24 S Protein of unknown function (DUF3970)
PFKLECOI_03177 2.5e-261 fumC 1.1.1.38, 4.2.1.2 C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
PFKLECOI_03178 4.3e-158 yuxN K Transcriptional regulator
PFKLECOI_03179 4.3e-250 cssS 2.7.13.3 T PhoQ Sensor
PFKLECOI_03180 3.4e-126 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
PFKLECOI_03181 1.5e-229 htrA 3.4.21.107 O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PFKLECOI_03182 4.7e-79 dps P Ferritin-like domain
PFKLECOI_03183 2.1e-137 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
PFKLECOI_03184 1.2e-129 2.3.1.29, 2.3.1.47 H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide
PFKLECOI_03185 1.1e-24
PFKLECOI_03186 2.4e-19 S Evidence 4 Homologs of previously reported genes of
PFKLECOI_03187 6.4e-36 2.6.1.76 E Psort location Cytoplasmic, score
PFKLECOI_03188 7.1e-07 K PFAM Acetyltransferase (GNAT) family
PFKLECOI_03189 8.6e-27 EGP Major facilitator Superfamily
PFKLECOI_03190 8.4e-26 Q methyltransferase
PFKLECOI_03191 2.2e-75 ecsA V ABC superfamily ATP binding cassette transporter ABC protein
PFKLECOI_03192 1.3e-23 ecsB U ABC transporter
PFKLECOI_03194 2.3e-299 pepF2 E COG1164 Oligoendopeptidase F
PFKLECOI_03195 2.5e-66 S YusW-like protein
PFKLECOI_03196 3.9e-153 yusV 3.6.3.34 HP ABC transporter
PFKLECOI_03197 1.1e-46 yusU S Protein of unknown function (DUF2573)
PFKLECOI_03198 2.2e-157 yusT K LysR substrate binding domain
PFKLECOI_03199 1.3e-107 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
PFKLECOI_03200 7.1e-65 yusQ S Tautomerase enzyme
PFKLECOI_03201 3.2e-292 yusP P Major facilitator superfamily
PFKLECOI_03202 5.4e-75 yusO K Iron dependent repressor, N-terminal DNA binding domain
PFKLECOI_03203 7.1e-53 yusN M Coat F domain
PFKLECOI_03204 5.1e-40
PFKLECOI_03205 1.1e-164 fadM E Proline dehydrogenase
PFKLECOI_03206 8.1e-09 S YuzL-like protein
PFKLECOI_03207 0.0 fadB 1.1.1.35, 4.2.1.17, 5.1.2.3 I 3-hydroxyacyl-CoA dehydrogenase
PFKLECOI_03208 2.7e-216 fadA 2.3.1.16 I Belongs to the thiolase family
PFKLECOI_03209 0.0 fadE 1.3.8.1 I acyl-CoA dehydrogenase
PFKLECOI_03210 2.8e-63 arsC 1.20.4.1 P Belongs to the ArsC family
PFKLECOI_03211 9.3e-65 gcvH E Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate
PFKLECOI_03212 1.1e-39 yusG S Protein of unknown function (DUF2553)
PFKLECOI_03213 2.1e-73 rnmV 3.1.26.8 L COG1658 Small primase-like proteins (Toprim domain)
PFKLECOI_03214 5.6e-55 traF CO Thioredoxin
PFKLECOI_03215 2.4e-56 yusD S SCP-2 sterol transfer family
PFKLECOI_03216 4.8e-185 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PFKLECOI_03217 1.4e-95 metI P COG2011 ABC-type metal ion transport system, permease component
PFKLECOI_03218 9.4e-147 metQ P Belongs to the NlpA lipoprotein family
PFKLECOI_03219 1.1e-62 yurZ 2.3.1.12, 4.1.1.44 S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PFKLECOI_03220 2.3e-142 sufC O COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component
PFKLECOI_03221 1.4e-245 sufD O assembly protein SufD
PFKLECOI_03222 9.4e-236 sufS 2.8.1.7, 4.4.1.16 E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PFKLECOI_03223 1.4e-77 nifU C COG0822 NifU homolog involved in Fe-S cluster formation
PFKLECOI_03224 3.5e-271 sufB O FeS cluster assembly
PFKLECOI_03225 2.9e-66 yurT E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PFKLECOI_03226 2.3e-41
PFKLECOI_03228 4.2e-206 yurR 1.4.5.1 E COG0665 Glycine D-amino acid oxidases (deaminating)
PFKLECOI_03229 2.8e-66 yurQ 2.7.7.7 L COG0322 Nuclease subunit of the excinuclease complex
PFKLECOI_03230 8.8e-184 frlB M Catalyzes the conversion of a range of fructosamine 6- phosphates to glucose 6-phosphate and a free amino acid
PFKLECOI_03231 4.2e-239 yurO G COG1653 ABC-type sugar transport system, periplasmic component
PFKLECOI_03232 5.3e-156 yurN G Binding-protein-dependent transport system inner membrane component
PFKLECOI_03233 5.2e-167 yurM P COG0395 ABC-type sugar transport system, permease component
PFKLECOI_03234 7.4e-163 yurL 2.7.1.218 G pfkB family carbohydrate kinase
PFKLECOI_03235 3.3e-135 yurK K UTRA
PFKLECOI_03236 7.7e-205 msmX P Belongs to the ABC transporter superfamily
PFKLECOI_03237 3.3e-158 gntR9 K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
PFKLECOI_03238 4.6e-73 azlC E AzlC protein
PFKLECOI_03239 1.5e-23 S branched-chain amino acid
PFKLECOI_03240 5.2e-164 bsn L Ribonuclease
PFKLECOI_03241 4.4e-233 pucF 3.5.1.6, 3.5.1.87, 3.5.3.9 E COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases
PFKLECOI_03242 8.7e-237 pucG 2.6.1.112, 2.6.1.44, 2.6.1.45, 2.6.1.51 E COG0075 Serine-pyruvate aminotransferase archaeal aspartate aminotransferase
PFKLECOI_03243 6.5e-187 pucA 1.17.1.4 O COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
PFKLECOI_03244 4.4e-109 pucB 1.1.1.328, 1.17.1.4, 2.7.7.76 S MobA-like NTP transferase domain
PFKLECOI_03245 1.4e-145 ygfM 1.17.1.4, 1.2.5.3 C COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM CutM homologs
PFKLECOI_03246 0.0 xdhA 1.17.1.4 C COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs
PFKLECOI_03247 8.1e-96 1.17.1.4, 1.2.5.3, 1.3.99.16 C COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs
PFKLECOI_03248 4.9e-57 uraH 3.5.2.17, 4.1.1.97 S Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily
PFKLECOI_03249 3.2e-278 uraD 1.7.3.3, 3.5.1.41, 4.1.1.97 Q Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin
PFKLECOI_03250 2.7e-217 pbuX F xanthine
PFKLECOI_03251 9.7e-234 pbuX F Permease family
PFKLECOI_03252 9.2e-300 pucR QT COG2508 Regulator of polyketide synthase expression
PFKLECOI_03253 4.3e-258 allB 3.5.2.5 F Catalyzes the conversion of allantoin (5- ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring
PFKLECOI_03254 1.4e-59 yunG
PFKLECOI_03255 4.3e-171 yunF S Protein of unknown function DUF72
PFKLECOI_03256 2e-141 yunE S membrane transporter protein
PFKLECOI_03257 4.6e-263 yunD 3.1.3.5 F Belongs to the 5'-nucleotidase family
PFKLECOI_03258 3.1e-47 yunC S Domain of unknown function (DUF1805)
PFKLECOI_03259 1e-131 yunB S Sporulation protein YunB (Spo_YunB)
PFKLECOI_03260 1.3e-195 lytH M Peptidase, M23
PFKLECOI_03261 1e-167 lipA 2.8.1.8 H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PFKLECOI_03262 1.1e-110 yutC S Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
PFKLECOI_03263 9.7e-48 yutD S protein conserved in bacteria
PFKLECOI_03264 1e-75 yutE S Protein of unknown function DUF86
PFKLECOI_03265 6.5e-142 nagD 2.7.1.25, 3.1.3.41 G Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
PFKLECOI_03266 2.5e-77 pgpA 3.1.3.27 I COG1267 Phosphatidylglycerophosphatase A and related proteins
PFKLECOI_03267 5.9e-199 yutH S Spore coat protein
PFKLECOI_03268 4.6e-241 hom 1.1.1.3 E homoserine dehydrogenase
PFKLECOI_03269 2.3e-198 thrC 4.2.3.1 E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PFKLECOI_03270 4.3e-172 thrB 2.7.1.39 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
PFKLECOI_03271 0.0 yuxL 3.4.14.5, 3.4.19.1 EU peptidase
PFKLECOI_03272 1.2e-35 yutI O COG0694 Thioredoxin-like proteins and domains
PFKLECOI_03273 8.7e-56 yuzD S protein conserved in bacteria
PFKLECOI_03274 2e-199 yutJ 1.6.99.3 C NADH dehydrogenase
PFKLECOI_03275 3.2e-39 yuzB S Belongs to the UPF0349 family
PFKLECOI_03276 5.3e-199 yutK F Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
PFKLECOI_03277 2.2e-162 dapF 5.1.1.7 E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PFKLECOI_03278 3.7e-63 erpA S Belongs to the HesB IscA family
PFKLECOI_03279 1.4e-71 paiA 2.3.1.57 K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
PFKLECOI_03280 6.5e-116 paiB K Putative FMN-binding domain
PFKLECOI_03281 1.9e-186 guaC 1.1.1.205, 1.7.1.7 F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
PFKLECOI_03283 3.5e-188 yumC 1.18.1.2, 1.19.1.1 C reductase
PFKLECOI_03284 2.5e-236 yumB 1.6.99.3 C NADH dehydrogenase
PFKLECOI_03285 8.4e-27 yuiB S Putative membrane protein
PFKLECOI_03286 1.4e-116 yuiC S protein conserved in bacteria
PFKLECOI_03287 1.2e-77 yuiD S protein conserved in bacteria
PFKLECOI_03288 3.4e-280 pepA 3.4.11.1, 3.4.11.5 E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PFKLECOI_03289 3.9e-211 yuiF S antiporter
PFKLECOI_03290 4.4e-93 bioY S Biotin biosynthesis protein
PFKLECOI_03291 5.8e-122 yuiH S Oxidoreductase molybdopterin binding domain
PFKLECOI_03292 7.4e-166 besA S Putative esterase
PFKLECOI_03293 2.1e-140 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
PFKLECOI_03294 4.3e-225 entC 5.4.4.2 HQ Isochorismate synthase
PFKLECOI_03295 0.0 entE 2.7.7.58, 6.3.2.14 Q 2,3-dihydroxybenzoate-AMP ligase
PFKLECOI_03296 3.1e-178 entB 3.3.2.1, 6.3.2.14 Q Isochorismatase family
PFKLECOI_03297 0.0 dhbF Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
PFKLECOI_03298 5e-36 mbtH S MbtH-like protein
PFKLECOI_03299 9.1e-132 yukJ S Uncharacterized conserved protein (DUF2278)
PFKLECOI_03300 1.4e-204 ald 1.4.1.1 E Belongs to the AlaDH PNT family
PFKLECOI_03301 1.5e-228 yukF QT Transcriptional regulator
PFKLECOI_03302 2.8e-45 esxA S Belongs to the WXG100 family
PFKLECOI_03303 3.8e-40 yukD S WXG100 protein secretion system (Wss), protein YukD
PFKLECOI_03304 2.3e-211 essB S WXG100 protein secretion system (Wss), protein YukC
PFKLECOI_03305 0.0 essC D COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins
PFKLECOI_03306 0.0 esaA S type VII secretion protein EsaA
PFKLECOI_03307 3.3e-64 yueC S Family of unknown function (DUF5383)
PFKLECOI_03308 2.2e-131 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
PFKLECOI_03309 4.8e-96 yueE S phosphohydrolase
PFKLECOI_03310 2.9e-24 S Protein of unknown function (DUF2642)
PFKLECOI_03311 7.5e-70 S Protein of unknown function (DUF2283)
PFKLECOI_03312 7.1e-190 yueF S transporter activity
PFKLECOI_03313 2.1e-32 yueG S Spore germination protein gerPA/gerPF
PFKLECOI_03314 7.4e-39 yueH S YueH-like protein
PFKLECOI_03315 7.9e-67 yueI S Protein of unknown function (DUF1694)
PFKLECOI_03316 1.5e-103 pncA Q COG1335 Amidases related to nicotinamidase
PFKLECOI_03317 3.6e-266 pncB 6.3.4.21 H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
PFKLECOI_03318 2.2e-232 yuxH 3.1.4.52 T signal transduction protein containing EAL and modified HD-GYP domains
PFKLECOI_03319 1.1e-22 yuzC
PFKLECOI_03321 3e-141 comQ H Belongs to the FPP GGPP synthase family
PFKLECOI_03323 2.6e-119 comP 2.7.13.3 T Histidine kinase
PFKLECOI_03324 3.8e-143 comP 2.7.13.3 T Histidine kinase
PFKLECOI_03325 5.1e-116 comA K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
PFKLECOI_03326 1.8e-63 ydiI Q protein, possibly involved in aromatic compounds catabolism
PFKLECOI_03327 6.7e-60 phaG P COG1320 Multisubunit Na H antiporter, MnhG subunit
PFKLECOI_03328 7.2e-38 phaF P Subunit F of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
PFKLECOI_03329 2.4e-78 mrpE P Subunit E of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
PFKLECOI_03330 1.2e-261 mrpD CP Subunit D of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
PFKLECOI_03331 1.5e-50 phaC 1.6.5.3 P Subunit C of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
PFKLECOI_03332 5.4e-69 mrpB P Subunit B of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
PFKLECOI_03333 0.0 phaA 1.6.5.3 CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit
PFKLECOI_03334 3.2e-14
PFKLECOI_03335 1.3e-233 maeN C COG3493 Na citrate symporter
PFKLECOI_03336 5e-168 yufQ S Belongs to the binding-protein-dependent transport system permease family
PFKLECOI_03337 1.9e-184 yufP S Belongs to the binding-protein-dependent transport system permease family
PFKLECOI_03338 1.6e-272 xylG 3.6.3.17 S ABC transporter, ATP-binding protein
PFKLECOI_03339 5.8e-197 tcsA S ABC-type transport system, periplasmic component surface lipoprotein
PFKLECOI_03340 3.9e-125 dcuR T COG4565 Response regulator of citrate malate metabolism
PFKLECOI_03341 3.8e-293 dcuS 2.7.13.3 T Signal transduction histidine kinase regulating citrate malate metabolism
PFKLECOI_03342 6.3e-78 yufK S Family of unknown function (DUF5366)
PFKLECOI_03343 1.8e-74 yuxK S protein conserved in bacteria
PFKLECOI_03344 0.0 mrcB 2.4.1.129, 3.4.16.4 GT51 M Penicillin-binding Protein
PFKLECOI_03345 3e-182 yuxJ EGP Major facilitator Superfamily
PFKLECOI_03347 4.2e-115 kapD L the KinA pathway to sporulation
PFKLECOI_03348 4.1e-68 kapB G Kinase associated protein B
PFKLECOI_03349 4.6e-233 T PhoQ Sensor
PFKLECOI_03350 1.6e-224 patB 4.4.1.8 E COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
PFKLECOI_03351 4.6e-39 yugE S Domain of unknown function (DUF1871)
PFKLECOI_03352 4.9e-156 yugF I Hydrolase
PFKLECOI_03353 1.6e-85 alaR K Transcriptional regulator
PFKLECOI_03354 2.1e-199 yugH 2.6.1.1 E Aminotransferase
PFKLECOI_03355 8.9e-63 yugI 5.3.1.9 J RNA binding protein (contains ribosomal protein S1 domain)
PFKLECOI_03356 1.1e-34 yuzA S Domain of unknown function (DUF378)
PFKLECOI_03357 2e-227 yugJ C oxidoreductases, Fe-dependent alcohol dehydrogenase family
PFKLECOI_03358 2.8e-229 yugK C Dehydrogenase
PFKLECOI_03359 4.2e-261 pgi 5.3.1.9 G Belongs to the GPI family
PFKLECOI_03361 2.8e-72 yugN S YugN-like family
PFKLECOI_03362 8.2e-182 yugO P COG1226 Kef-type K transport systems
PFKLECOI_03363 5.4e-53 mstX S Membrane-integrating protein Mistic
PFKLECOI_03364 3.9e-38
PFKLECOI_03365 1.4e-116 yugP S Zn-dependent protease
PFKLECOI_03366 2.9e-235 yugS S COG1253 Hemolysins and related proteins containing CBS domains
PFKLECOI_03367 0.0 yugT 3.2.1.10, 3.2.1.20 GH13,GH31 G COG0366 Glycosidases
PFKLECOI_03368 2.1e-72 yugU S Uncharacterised protein family UPF0047
PFKLECOI_03369 2.3e-35
PFKLECOI_03370 9.9e-140 tgl 2.3.2.13 S protein-glutamine gamma-glutamyltransferase activity
PFKLECOI_03371 3.2e-225 mcpA NT chemotaxis protein
PFKLECOI_03372 6.9e-220 mcpA NT chemotaxis protein
PFKLECOI_03373 1.4e-294 mcpA NT chemotaxis protein
PFKLECOI_03374 7.3e-238 mcpA NT chemotaxis protein
PFKLECOI_03375 0.0 rhaD 1.1.1.1, 4.1.2.19 IQ Class II Aldolase and Adducin N-terminal domain
PFKLECOI_03376 3.8e-134 fucR K COG1349 Transcriptional regulators of sugar metabolism
PFKLECOI_03377 1.1e-275 rhaB 2.7.1.12, 2.7.1.17, 2.7.1.5, 5.3.1.14 G Involved in the catabolism of L-rhamnose (6-deoxy-L- mannose). Catalyzes the transfer of the gamma-phosphate group from ATP to the 1-hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate
PFKLECOI_03378 1.6e-54 rhaM 5.1.3.32 G Involved in the anomeric conversion of L-rhamnose
PFKLECOI_03379 1.8e-250 rhaA 2.7.1.5, 5.3.1.14 G Belongs to the rhamnose isomerase family
PFKLECOI_03380 3.3e-183 ygjR S Oxidoreductase
PFKLECOI_03381 1.3e-194 yubA S transporter activity
PFKLECOI_03382 2.7e-133 uppP 3.6.1.27 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
PFKLECOI_03384 1.3e-87 cdoA 1.13.11.20 S Cysteine dioxygenase type I
PFKLECOI_03385 1.6e-272 yubD P Major Facilitator Superfamily
PFKLECOI_03386 6.4e-153 NU Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
PFKLECOI_03387 1e-38 yiaA S yiaA/B two helix domain
PFKLECOI_03388 7.9e-236 ktrB P Potassium
PFKLECOI_03389 3.2e-121 ktrA P COG0569 K transport systems, NAD-binding component
PFKLECOI_03390 2.2e-91 yuaB
PFKLECOI_03391 5.5e-95 yuaC K Belongs to the GbsR family
PFKLECOI_03392 1.8e-281 gbsA 1.2.1.8 C Belongs to the aldehyde dehydrogenase family
PFKLECOI_03393 1.1e-228 gbsB 1.1.1.1 C alcohol dehydrogenase
PFKLECOI_03394 7.9e-108 yuaD
PFKLECOI_03395 3.9e-84 yuaE S DinB superfamily
PFKLECOI_03396 1e-74 yuaF OU Membrane protein implicated in regulation of membrane protease activity
PFKLECOI_03397 7e-188 yuaG 3.4.21.72 S protein conserved in bacteria
PFKLECOI_03398 3.2e-92 M1-753 M FR47-like protein
PFKLECOI_03399 4.3e-90 thiT S Thiamine transporter protein (Thia_YuaJ)
PFKLECOI_03400 0.0 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PFKLECOI_03401 0.0 gyrB 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PFKLECOI_03402 1.8e-37 yaaB S Domain of unknown function (DUF370)
PFKLECOI_03403 3.2e-206 recF L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PFKLECOI_03404 2.4e-33 yaaA S S4 domain
PFKLECOI_03405 1.8e-204 dnaN 2.7.7.7 L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
PFKLECOI_03406 6e-252 dnaA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PFKLECOI_03407 3e-54 rnpA 3.1.26.5 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
PFKLECOI_03408 1.7e-118 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
PFKLECOI_03409 6.5e-108 jag S single-stranded nucleic acid binding R3H
PFKLECOI_03410 8.3e-249 mnmE S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PFKLECOI_03411 0.0 gidA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
PFKLECOI_03412 1.4e-130 rsmG 2.1.1.170 J Specifically methylates the N7 position of guanine in position 535 of 16S rRNA
PFKLECOI_03413 1.9e-150 noc D Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage
PFKLECOI_03414 9.6e-74 S Bacterial PH domain
PFKLECOI_03415 2.2e-134 soj D COG1192 ATPases involved in chromosome partitioning
PFKLECOI_03416 2.1e-149 spo0J K Belongs to the ParB family
PFKLECOI_03417 2.8e-111 yyaC S Sporulation protein YyaC
PFKLECOI_03418 8.1e-177 yyaD S Membrane
PFKLECOI_03419 2.3e-33 yyzM S protein conserved in bacteria
PFKLECOI_03420 0.0 yyaE C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
PFKLECOI_03421 4e-201 ychF J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
PFKLECOI_03422 5.6e-46 rpsF J Binds together with S18 to 16S ribosomal RNA
PFKLECOI_03423 2.9e-69 ssb L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
PFKLECOI_03424 5.1e-37 rpsR J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PFKLECOI_03425 2.2e-142 xth 3.1.11.2 L exodeoxyribonuclease III
PFKLECOI_03426 6.8e-178 ccpB 3.5.1.4, 5.1.1.1 K Transcriptional regulator
PFKLECOI_03427 5.8e-67 yyaH 4.4.1.5 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PFKLECOI_03428 8.1e-94 maa 2.3.1.79 S Bacterial transferase hexapeptide (six repeats)
PFKLECOI_03429 6.1e-244 EGP Major facilitator superfamily
PFKLECOI_03430 4e-167 yyaK S CAAX protease self-immunity
PFKLECOI_03431 0.0 yyaL O COG1331 Highly conserved protein containing a thioredoxin domain
PFKLECOI_03432 1.7e-249 tetL EGP Major facilitator Superfamily
PFKLECOI_03433 1e-104 yyaP 1.5.1.3 H RibD C-terminal domain
PFKLECOI_03434 3e-65 yyaQ S YjbR
PFKLECOI_03435 3e-90 yyaR K Acetyltransferase (GNAT) domain
PFKLECOI_03436 5.5e-96 yyaS S Membrane
PFKLECOI_03437 2.4e-72 yjcF S Acetyltransferase (GNAT) domain
PFKLECOI_03438 5.6e-77 yybA 2.3.1.57 K transcriptional
PFKLECOI_03439 1.4e-124 S Metallo-beta-lactamase superfamily
PFKLECOI_03440 2.3e-73 yybC
PFKLECOI_03441 1.1e-77 yjcF S Acetyltransferase (GNAT) domain
PFKLECOI_03442 6.9e-164 yybE K Transcriptional regulator
PFKLECOI_03443 6.3e-216 ynfM EGP Major facilitator Superfamily
PFKLECOI_03444 6.9e-121 yybG S Pentapeptide repeat-containing protein
PFKLECOI_03445 8.6e-66 yybH S SnoaL-like domain
PFKLECOI_03446 2.8e-124
PFKLECOI_03447 2.2e-110 K TipAS antibiotic-recognition domain
PFKLECOI_03448 1.8e-240 yybO G COG0477 Permeases of the major facilitator superfamily
PFKLECOI_03450 1.6e-60
PFKLECOI_03451 1.1e-164 ppaC 3.6.1.1 C Inorganic pyrophosphatase
PFKLECOI_03452 7.5e-67 ydeP3 K Transcriptional regulator
PFKLECOI_03453 3.9e-84 cotF M Spore coat protein
PFKLECOI_03455 2.9e-160 yybS S membrane
PFKLECOI_03456 0.0 yybT T signaling protein consisting of a modified GGDEF domain and a DHH domain
PFKLECOI_03457 2.2e-73 rplI J binds to the 23S rRNA
PFKLECOI_03458 0.0 yycA M COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PFKLECOI_03459 2.5e-220 yeaN P COG2807 Cyanate permease
PFKLECOI_03460 1.9e-15 yycC K YycC-like protein
PFKLECOI_03462 1.9e-29 yycD S Uncharacterized protein conserved in bacteria (DUF2188)
PFKLECOI_03463 3e-251 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
PFKLECOI_03464 4.4e-76 yycE 3.4.21.26, 5.3.1.24 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PFKLECOI_03465 3e-248 purA 6.3.4.4 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PFKLECOI_03470 1.1e-132 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
PFKLECOI_03471 0.0 vicK 2.7.13.3 T Histidine kinase
PFKLECOI_03472 3.4e-258 yycH S protein conserved in bacteria
PFKLECOI_03473 1.8e-153 yycI S protein conserved in bacteria
PFKLECOI_03474 1.9e-149 vicX 3.1.26.11 S COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I
PFKLECOI_03475 8.7e-218 htrA 3.4.21.107 O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PFKLECOI_03476 2.7e-24 S Peptidase propeptide and YPEB domain
PFKLECOI_03477 4e-74 S Peptidase propeptide and YPEB domain
PFKLECOI_03478 1.5e-94 K PFAM response regulator receiver
PFKLECOI_03479 4.7e-173 phoR3 2.7.13.3 T COG0642 Signal transduction histidine kinase
PFKLECOI_03480 4.4e-258 rocR KT COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains
PFKLECOI_03481 7.3e-233 rocD 2.6.1.11, 2.6.1.13, 2.6.1.17 E Catalyzes the interconversion of ornithine to glutamate semialdehyde
PFKLECOI_03482 1.3e-260 rocE E amino acid
PFKLECOI_03483 2.3e-167 rocF 3.5.3.1, 3.5.3.11 E Belongs to the arginase family
PFKLECOI_03485 8.8e-185 S aspartate phosphatase
PFKLECOI_03486 3.8e-84 yycN 2.3.1.128 K Acetyltransferase
PFKLECOI_03487 5.8e-132 yycO S Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
PFKLECOI_03488 3.6e-213 yycP
PFKLECOI_03489 9.7e-31 yycQ S Protein of unknown function (DUF2651)
PFKLECOI_03491 3e-234 fdhA 1.1.1.1, 1.1.1.14, 1.1.1.284, 1.2.1.46 E COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
PFKLECOI_03492 4.4e-68
PFKLECOI_03493 1.1e-09 S YyzF-like protein
PFKLECOI_03494 2e-80 rlmH 2.1.1.177 J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
PFKLECOI_03495 1.2e-19
PFKLECOI_03496 7.1e-109 L reverse transcriptase
PFKLECOI_03497 2e-118 atmc2 S Caspase domain
PFKLECOI_03498 3e-42 S MazG-like family
PFKLECOI_03499 3.9e-245 L Uncharacterized conserved protein (DUF2075)
PFKLECOI_03500 0.0 L AAA domain
PFKLECOI_03501 0.0 fbp 3.1.3.11 G Firmicute fructose-1,6-bisphosphatase
PFKLECOI_03502 8.4e-12
PFKLECOI_03503 9.3e-127 yydK K Transcriptional regulator
PFKLECOI_03504 4.1e-36 bglF G phosphotransferase system
PFKLECOI_03505 4.1e-291 bglA 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
PFKLECOI_03506 1.2e-188 wgaE S Polysaccharide pyruvyl transferase
PFKLECOI_03507 1.9e-286 ahpF O Alkyl hydroperoxide reductase
PFKLECOI_03508 2.1e-105 ahpC 1.11.1.15 O Alkyl hydroperoxide reductase
PFKLECOI_03509 8.5e-273 gnd 1.1.1.343, 1.1.1.44 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
PFKLECOI_03510 4.5e-231 gntP EG COG2610 H gluconate symporter and related permeases
PFKLECOI_03511 4.3e-302 gntK 2.7.1.12, 2.7.1.17, 2.7.1.5 G Belongs to the FGGY kinase family
PFKLECOI_03512 2.8e-126 gntR K transcriptional
PFKLECOI_03513 8.6e-207 glxK 2.7.1.165 G Belongs to the glycerate kinase type-1 family
PFKLECOI_03514 3.7e-193 yxaB GM Polysaccharide pyruvyl transferase
PFKLECOI_03515 2.6e-118 yxaC M effector of murein hydrolase
PFKLECOI_03516 5.2e-50 S LrgA family
PFKLECOI_03517 4.4e-71 yxaD K helix_turn_helix multiple antibiotic resistance protein
PFKLECOI_03518 2.3e-198 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
PFKLECOI_03519 1.2e-100 yxaF K Transcriptional regulator
PFKLECOI_03520 7.1e-197 yxaG 1.13.11.24 S AraC-like ligand binding domain
PFKLECOI_03521 3.9e-226 P Protein of unknown function (DUF418)
PFKLECOI_03522 4e-75 yxaI S membrane protein domain
PFKLECOI_03523 3.5e-65 S Family of unknown function (DUF5391)
PFKLECOI_03524 4.4e-92 S PQQ-like domain
PFKLECOI_03525 7.6e-214 yxaM U MFS_1 like family
PFKLECOI_03526 0.0 asnB 6.3.5.4 E Asparagine synthase
PFKLECOI_03527 1.1e-86 yxnB
PFKLECOI_03528 4.9e-44 S Coenzyme PQQ synthesis protein D (PqqD)
PFKLECOI_03529 1.3e-126 yxbB Q Met-10+ like-protein
PFKLECOI_03530 2.2e-187 yxbC 1.14.11.47 S A domain family that is part of the cupin metalloenzyme superfamily.
PFKLECOI_03531 1.6e-85 yxbD 3.2.2.20 K Acetyltransferase (GNAT) domain
PFKLECOI_03532 5.2e-248 alkH 1.2.1.3 C Belongs to the aldehyde dehydrogenase family
PFKLECOI_03533 5.9e-208 yxbF K Bacterial regulatory proteins, tetR family
PFKLECOI_03534 8.2e-151 IQ Enoyl-(Acyl carrier protein) reductase
PFKLECOI_03536 0.0 htpG O Molecular chaperone. Has ATPase activity
PFKLECOI_03537 3.3e-245 csbC EGP Major facilitator Superfamily
PFKLECOI_03538 8.3e-48 yxcD S Protein of unknown function (DUF2653)
PFKLECOI_03540 2e-174 iolS C Aldo keto reductase
PFKLECOI_03541 3.3e-138 iolR K COG1349 Transcriptional regulators of sugar metabolism
PFKLECOI_03542 1.8e-281 iolA 1.2.1.18, 1.2.1.27 C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
PFKLECOI_03543 4.6e-154 iolB 5.3.1.30 G Involved in the isomerization of 5-deoxy-glucuronate (5DG) to 5-dehydro-2-deoxy-D-gluconate (DKG or 2-deoxy-5-keto-D- gluconate)
PFKLECOI_03544 1.4e-178 iolC 2.7.1.92 G Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D- gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5- dehydro-2-deoxy-D-gluconate (DKGP)
PFKLECOI_03545 0.0 iolD 3.7.1.22 E Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG)
PFKLECOI_03546 2.3e-175 iolE 4.2.1.44 G Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol)
PFKLECOI_03547 5.1e-235 iolF EGP Major facilitator Superfamily
PFKLECOI_03548 3.1e-195 iolG 1.1.1.18, 1.1.1.369 S Involved in the oxidation of myo-inositol (MI) and D- chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively
PFKLECOI_03549 8.6e-167 iolH G Xylose isomerase-like TIM barrel
PFKLECOI_03550 2.8e-138 iolI 5.3.99.11 G Involved in the reversible interconverion of 2-keto-myo- inositol (2KMI, inosose or 2,4,6 3,5-pentahydroxycyclohexanone) to 1-keto-D-chiro-inositol (1KDCI or 2,3,5 4,6- pentahydroxycyclohexanone)
PFKLECOI_03551 5.4e-161 iolJ 4.1.2.13, 4.1.2.29 F Produces dihydroxyacetone phosphate (DHAP or glycerone phosphate) and malonic semialdehyde (MSA or 3-oxopropanoate) from 6-phospho-5-dehydro-2-deoxy-D-gluconate (DKGP)
PFKLECOI_03552 2.7e-123 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
PFKLECOI_03553 4e-181 T PhoQ Sensor
PFKLECOI_03554 9.4e-141 yxdL V ABC transporter, ATP-binding protein
PFKLECOI_03555 0.0 yxdM V ABC transporter (permease)
PFKLECOI_03556 1.5e-58 yxeA S Protein of unknown function (DUF1093)
PFKLECOI_03557 2.3e-176 fhuD P ABC transporter
PFKLECOI_03558 1.4e-68
PFKLECOI_03559 5.6e-16 yxeD
PFKLECOI_03560 1.3e-20 yxeE
PFKLECOI_03563 1.8e-150 yidA S hydrolases of the HAD superfamily
PFKLECOI_03564 4.4e-183 yxeI 3.5.1.24 M Linear amide C-N hydrolases, choloylglycine hydrolase family
PFKLECOI_03565 4.9e-254 yxeK C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PFKLECOI_03566 7.3e-94 yxeL K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
PFKLECOI_03567 2.5e-144 yxeM M Belongs to the bacterial solute-binding protein 3 family
PFKLECOI_03568 2.7e-107 yxeN P COG0765 ABC-type amino acid transport system, permease component
PFKLECOI_03569 5.4e-133 yxeO 3.6.3.21 P ABC transporter, ATP-binding protein
PFKLECOI_03570 8e-213 yxeP 3.5.1.47 E hydrolase activity
PFKLECOI_03571 1.1e-250 yxeQ S MmgE/PrpD family
PFKLECOI_03572 3.2e-198 eutH E Ethanolamine utilisation protein, EutH
PFKLECOI_03573 2e-152 yxxB S Domain of Unknown Function (DUF1206)
PFKLECOI_03574 7.9e-174 deoR K COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain
PFKLECOI_03575 2e-115 deoC 4.1.2.4 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
PFKLECOI_03576 9.8e-206 nupC F Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
PFKLECOI_03577 1.8e-232 pdp 2.4.2.2, 2.4.2.4 F phosphorylase
PFKLECOI_03578 3.4e-250 lysP E amino acid
PFKLECOI_03579 1.8e-178 hutG 3.5.3.11, 3.5.3.8 E Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide
PFKLECOI_03580 1.5e-236 hutI 3.5.2.7 Q Imidazolone-5-propionate hydrolase
PFKLECOI_03581 0.0 hutU 4.2.1.49 E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
PFKLECOI_03582 7e-281 hutH 4.3.1.3 E Histidine ammonia-lyase
PFKLECOI_03583 5e-78 hutP K Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization
PFKLECOI_03585 3.7e-276 yxiA 3.2.1.99 GH43 G Belongs to the glycosyl hydrolase 43 family
PFKLECOI_03586 1.1e-58 nudG 3.6.1.55, 3.6.1.65 L COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
PFKLECOI_03588 0.0 L HKD family nuclease
PFKLECOI_03589 2.3e-20 S Domain of unknown function (DUF5082)
PFKLECOI_03590 1.4e-38 yxiC S Family of unknown function (DUF5344)
PFKLECOI_03591 6.2e-219 S nuclease activity
PFKLECOI_03592 5.5e-53
PFKLECOI_03593 1.5e-309 bglF 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
PFKLECOI_03594 1e-278 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
PFKLECOI_03595 1.1e-72 yxiE T Belongs to the universal stress protein A family
PFKLECOI_03596 9.6e-164 yxxF EG EamA-like transporter family
PFKLECOI_03597 0.0 wapA M COG3209 Rhs family protein
PFKLECOI_03598 1.5e-71 yxxG
PFKLECOI_03599 1.7e-84
PFKLECOI_03600 6.4e-63
PFKLECOI_03601 3.7e-75 yxiG
PFKLECOI_03602 3.7e-138
PFKLECOI_03603 1.6e-93 yxiI S Protein of unknown function (DUF2716)
PFKLECOI_03604 5.7e-46 yxiJ S YxiJ-like protein
PFKLECOI_03607 6.4e-210 3.2.1.14 GH18 E GDSL-like Lipase/Acylhydrolase
PFKLECOI_03608 8.7e-265 dbpA 3.6.4.13 JKL DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes
PFKLECOI_03609 2.3e-229 yxiO S COG2270 Permeases of the major facilitator superfamily
PFKLECOI_03610 1.2e-110
PFKLECOI_03611 8.3e-151 licT K transcriptional antiterminator
PFKLECOI_03612 3.6e-142 exoK GH16 M licheninase activity
PFKLECOI_03613 6.6e-224 citH C Citrate transporter
PFKLECOI_03614 0.0 katE 1.11.1.6, 3.5.1.124 P serves to protect cells from the toxic effects of hydrogen peroxide
PFKLECOI_03615 3e-47 yxiS
PFKLECOI_03616 1.5e-102 T Domain of unknown function (DUF4163)
PFKLECOI_03617 1.2e-211 nupG F Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
PFKLECOI_03618 1.9e-158 rlmA 2.1.1.187 Q Methyltransferase domain
PFKLECOI_03619 4.4e-253 yxjC EG COG2610 H gluconate symporter and related permeases
PFKLECOI_03620 1.8e-130 scoA 2.8.3.5 I COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PFKLECOI_03621 5.2e-116 scoB 2.8.3.5 I COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit
PFKLECOI_03622 2.4e-136 IQ Catalyzes the formation of acetoacetate from 3-hydroxybutyrate
PFKLECOI_03623 3.1e-217 yxjG 2.1.1.14 E Methionine synthase
PFKLECOI_03624 6.7e-220 yxjG 2.1.1.14 E Methionine synthase
PFKLECOI_03625 1.6e-85 yxjI S LURP-one-related
PFKLECOI_03628 3.6e-235 pepT 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
PFKLECOI_03629 4.9e-114 K helix_turn_helix, Lux Regulon
PFKLECOI_03630 9.2e-191 yxjM T Signal transduction histidine kinase
PFKLECOI_03631 5.9e-77 S Protein of unknown function (DUF1453)
PFKLECOI_03632 1e-195 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
PFKLECOI_03633 2.8e-74 yxkC S Domain of unknown function (DUF4352)
PFKLECOI_03634 1.9e-147 yxkD S Uncharacterised 5xTM membrane BCR, YitT family COG1284
PFKLECOI_03635 1.6e-274 aldY 1.2.1.3 C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
PFKLECOI_03636 2.7e-163 lrp QT PucR C-terminal helix-turn-helix domain
PFKLECOI_03637 5.9e-205 msmK P Belongs to the ABC transporter superfamily
PFKLECOI_03638 1.6e-154 yxkH G Polysaccharide deacetylase
PFKLECOI_03640 3.5e-310 3.4.24.84 O Peptidase family M48
PFKLECOI_03641 1.5e-229 cimH C COG3493 Na citrate symporter
PFKLECOI_03642 1.3e-268 cydA 1.10.3.14 C oxidase, subunit
PFKLECOI_03643 6.5e-190 cydB 1.10.3.14 C Cytochrome d ubiquinol oxidase, subunit II
PFKLECOI_03644 0.0 cydD V ATP-binding
PFKLECOI_03645 0.0 cydD V ATP-binding protein
PFKLECOI_03646 5.3e-158 nnrD 4.2.1.136, 5.1.99.6 G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PFKLECOI_03647 2.3e-254 yxlA F Belongs to the purine-cytosine permease (2.A.39) family
PFKLECOI_03648 4.7e-91 sigY K Belongs to the sigma-70 factor family. ECF subfamily
PFKLECOI_03649 3.9e-48 yxlC S Family of unknown function (DUF5345)
PFKLECOI_03650 1.2e-31
PFKLECOI_03651 7.6e-28 yxlE S Phospholipase_D-nuclease N-terminal
PFKLECOI_03652 4.8e-165 yxlF V ABC transporter, ATP-binding protein
PFKLECOI_03653 9.3e-32 yxlG S COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
PFKLECOI_03654 3.6e-88 yxlG S COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
PFKLECOI_03655 1.2e-211 yxlH EGP Major facilitator Superfamily
PFKLECOI_03656 0.0 katX 1.11.1.6 P serves to protect cells from the toxic effects of hydrogen peroxide
PFKLECOI_03657 5e-110 mpg 3.2.2.21 L Belongs to the DNA glycosylase MPG family
PFKLECOI_03658 1.1e-19 yxzF
PFKLECOI_03659 0.0 licR 2.7.1.202 GKT Mga helix-turn-helix domain
PFKLECOI_03660 2.3e-50 licB 2.7.1.196, 2.7.1.205 G transporter subunit IIB
PFKLECOI_03661 2.8e-249 licC G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
PFKLECOI_03662 1.1e-37 licA 2.7.1.196, 2.7.1.205 G phosphotransferase system
PFKLECOI_03663 1.6e-252 licH 3.2.1.86 GT4 G COG1486 Alpha-galactosidases 6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases
PFKLECOI_03664 1.2e-205 ilvE 2.6.1.42 E Branched-chain amino acid aminotransferase
PFKLECOI_03665 2.1e-137 dltE M Belongs to the short-chain dehydrogenases reductases (SDR) family
PFKLECOI_03666 2.3e-231 dltD M COG3966 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
PFKLECOI_03667 1.5e-36 dltC 6.1.1.13 IQ Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
PFKLECOI_03668 1.2e-232 dltB M membrane protein involved in D-alanine export
PFKLECOI_03669 9.7e-291 dltA 6.1.1.13 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
PFKLECOI_03670 1.5e-164 menA 2.5.1.74 H Belongs to the MenA family. Type 1 subfamily
PFKLECOI_03671 5e-116 ywaC 2.7.6.5 S protein conserved in bacteria
PFKLECOI_03672 1e-130 ynfM EGP Major facilitator Superfamily
PFKLECOI_03673 4.2e-49 4.1.1.44 S Carboxymuconolactone decarboxylase family
PFKLECOI_03674 1.4e-92 K Helix-turn-helix XRE-family like proteins
PFKLECOI_03675 3.7e-249 ywaD 3.4.11.10, 3.4.11.6 S PA domain
PFKLECOI_03676 1.3e-229 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PFKLECOI_03677 4e-87 ywaE K Transcriptional regulator
PFKLECOI_03678 3.7e-123 ywaF S Integral membrane protein
PFKLECOI_03679 2.9e-167 gspA M General stress
PFKLECOI_03680 4e-153 sacY K transcriptional antiterminator
PFKLECOI_03681 2.2e-241 scrA 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
PFKLECOI_03682 7.5e-272 epr 3.4.21.62 O Belongs to the peptidase S8 family
PFKLECOI_03683 2.1e-244 celB G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
PFKLECOI_03684 4.4e-67 ywbC 4.4.1.5 E glyoxalase
PFKLECOI_03685 5.4e-220 ywbD 2.1.1.191 J Methyltransferase
PFKLECOI_03686 1.4e-27 ywbE S Uncharacterized conserved protein (DUF2196)
PFKLECOI_03687 3.1e-207 ywbF EGP Major facilitator Superfamily
PFKLECOI_03688 6.8e-111 ywbG M effector of murein hydrolase
PFKLECOI_03689 6.5e-58 ywbH S Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein. When a cell is stressed by the addition of antibiotics or by other factors in the environment, CidA possibly oligomerizes within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are also hypothesized to regulate the subsequent cell lysis by either allowing the murein hydrolases access to the cell wall substrate and or regulating their activity by a
PFKLECOI_03690 5.8e-153 ywbI K Transcriptional regulator
PFKLECOI_03691 8.2e-143 thiM 2.7.1.50 H Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
PFKLECOI_03692 2.5e-113 thiE 2.5.1.3, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
PFKLECOI_03693 3.4e-253 P COG0672 High-affinity Fe2 Pb2 permease
PFKLECOI_03694 4.3e-182 ycdO P periplasmic lipoprotein involved in iron transport
PFKLECOI_03695 3.2e-223 ywbN P Dyp-type peroxidase family protein
PFKLECOI_03696 1.2e-109 ywbO Q dithiol-disulfide isomerase involved in polyketide biosynthesis
PFKLECOI_03697 1.4e-268 ywcA S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PFKLECOI_03698 9.8e-49 ywcB S Protein of unknown function, DUF485
PFKLECOI_03700 1.1e-121 ywcC K transcriptional regulator
PFKLECOI_03701 9.5e-60 gtcA S GtrA-like protein
PFKLECOI_03702 6.9e-228 galK 2.7.1.6 G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
PFKLECOI_03703 4e-300 galT 2.7.7.12 G UDP-glucose--hexose-1-phosphate uridylyltransferase
PFKLECOI_03704 1e-35 ywzA S membrane
PFKLECOI_03705 2.1e-177 cyoA 1.10.3.10, 1.10.3.12 C Catalyzes quinol oxidation with the concomitant reduction of oxygen to water. Subunit II transfers the electrons from a quinol to the binuclear center of the catalytic subunit I
PFKLECOI_03706 0.0 qoxB 1.10.3.12, 1.9.3.1 C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PFKLECOI_03707 1.2e-111 qoxC 1.10.3.12, 1.9.3.1 C quinol oxidase, subunit
PFKLECOI_03708 2.6e-64 qoxD 1.10.3.12, 1.9.3.1 C quinol oxidase, subunit
PFKLECOI_03709 6e-39 ywcE S Required for proper spore morphogenesis. Important for spore germination
PFKLECOI_03710 2.9e-202 rodA D Belongs to the SEDS family
PFKLECOI_03711 2.1e-137 nfrA 1.5.1.38, 1.5.1.39 C Oxidoreductase
PFKLECOI_03712 9.5e-186 ywcH C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PFKLECOI_03713 0.0 vpr O Belongs to the peptidase S8 family
PFKLECOI_03715 7e-150 sacT K transcriptional antiterminator
PFKLECOI_03716 2.3e-139 focA P Formate/nitrite transporter
PFKLECOI_03717 1.6e-252 scrA 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
PFKLECOI_03718 3.6e-279 scrB 3.2.1.26, 3.2.1.65, 3.2.1.80 GH32 G invertase
PFKLECOI_03719 2e-28 ywdA
PFKLECOI_03720 3.5e-146 thiD 2.5.1.3, 2.7.1.35, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Phosphomethylpyrimidine kinase
PFKLECOI_03721 1.3e-57 pex K Transcriptional regulator PadR-like family
PFKLECOI_03722 1.4e-113 ywdD
PFKLECOI_03724 1.2e-151 ywdF GT2,GT4 S Glycosyltransferase like family 2
PFKLECOI_03725 1.1e-129 ung 3.2.2.27 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
PFKLECOI_03726 1.5e-261 ywdH 1.2.1.3 C Belongs to the aldehyde dehydrogenase family
PFKLECOI_03727 5e-48 ywdI S Family of unknown function (DUF5327)
PFKLECOI_03728 3.7e-238 ywdJ F Xanthine uracil
PFKLECOI_03729 4.3e-59 ywdK S small membrane protein
PFKLECOI_03730 4.8e-75 gerQ S Essential for the localization of CwlJ in the spore coat and for spore germination triggered by calcium and dipicolinic acid (DPA). Its assembly into the spore coat is dependent on the coat morphogenetic proteins CotE and SpoIVA
PFKLECOI_03731 2e-143 spsA M Spore Coat
PFKLECOI_03732 3.3e-269 spsB M Capsule polysaccharide biosynthesis protein
PFKLECOI_03733 3.5e-224 spsC E Belongs to the DegT DnrJ EryC1 family
PFKLECOI_03734 1.2e-163 spsD 2.3.1.210 K Spore Coat
PFKLECOI_03735 2.7e-213 spsE 2.5.1.56 M acid synthase
PFKLECOI_03736 3.2e-127 spsF M Spore Coat
PFKLECOI_03737 7.4e-186 spsG M Spore Coat
PFKLECOI_03738 7.1e-138 spsI 2.7.7.24 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
PFKLECOI_03739 5.1e-181 rfbB 4.2.1.46 M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
PFKLECOI_03740 1.5e-160 spsK 1.1.1.133 M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
PFKLECOI_03741 1.3e-86 spsL 5.1.3.13 M Spore Coat
PFKLECOI_03742 1.2e-77
PFKLECOI_03743 1.3e-243 rocG 1.4.1.2, 1.4.1.3 E Belongs to the Glu Leu Phe Val dehydrogenases family
PFKLECOI_03744 2.3e-295 putA 1.2.1.88, 1.5.5.2 C Belongs to the aldehyde dehydrogenase family. RocA subfamily
PFKLECOI_03745 0.0 rocB E arginine degradation protein
PFKLECOI_03746 2.8e-249 lysP E amino acid
PFKLECOI_03747 4.6e-206 ywfA EGP Major facilitator Superfamily
PFKLECOI_03748 8.6e-113 pheA 1.1.1.3, 1.3.1.12, 4.1.1.100, 4.2.1.51, 5.4.99.5 E Part of the bacABCDEF operon responsible for the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase. BacA is an unusual prephenate decarboxylase that avoids the typical aromatization of the cyclohexadienol ring of prephenate. BacA catalyzes the protonation of prephenate (1-carboxy-4-hydroxy-alpha-oxo-2,5-cyclohexadiene-1- propanoic acid) at C6 position, followed by a decarboxylation to produce the endocyclic-delta(4),delta(8)-7R-dihydro- hydroxyphenylpyruvate (en-H2HPP). En-H2HPP is able to undergo a slow nonenzymatic isomerization to produce the exocyclic- delta(3),delta(5)-dihydro-hydroxyphenylpyruvate (ex-H2HPP). BacA isomerizes only the pro-R double bond in prephenate
PFKLECOI_03749 1.3e-136 bacB 5.3.3.19, 5.4.99.5 S Part of the bacABCDEF operon responsible for the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase. BacB catalyzes the allylic isomerization of the
PFKLECOI_03750 1.1e-138 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
PFKLECOI_03751 2.3e-270 purD 6.3.2.49, 6.3.4.13 F Part of the bacABCDEFG operon responsible for the biosynthesis of bacilysin, an irreversible inactivator of the glutaminase domain of glucosamine synthetase. Catalyzes the formation of alpha-dipeptides from various L-amino acids in the presence of ATP. In vivo catalyzes the ligation of L-alanine and L-anticapsin (epoxycyclohexanonyl-Ala) to produce the final bacilysin antibiotic (L-Ala-L-4S-cyclohexenonyl-Ala dipeptide)
PFKLECOI_03752 1.9e-209 bacE EGP Major facilitator Superfamily
PFKLECOI_03753 1.1e-233 ywfG 2.6.1.83 E Aminotransferase class I and II
PFKLECOI_03754 3.4e-138 IQ Enoyl-(Acyl carrier protein) reductase
PFKLECOI_03755 3.3e-146 ywfI C May function as heme-dependent peroxidase
PFKLECOI_03756 5.6e-175 pta 2.3.1.19, 2.3.1.8, 3.6.3.21 C In Salmonella this enzyme is required for ethanolamine catabolism
PFKLECOI_03757 5.2e-159 cysL K Transcriptional regulator
PFKLECOI_03758 6.6e-156 lipL 2.3.1.200, 2.3.1.204 H Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes
PFKLECOI_03759 9.8e-158 ywfM EG EamA-like transporter family
PFKLECOI_03760 1e-110 rsfA_1
PFKLECOI_03761 3.1e-36 ywzC S Belongs to the UPF0741 family
PFKLECOI_03762 5.1e-256 ywfO S COG1078 HD superfamily phosphohydrolases
PFKLECOI_03763 5.4e-89 ywgA 2.1.1.72, 3.1.21.3
PFKLECOI_03764 6.2e-79 yffB K Transcriptional regulator
PFKLECOI_03765 1.8e-238 mmr U Major Facilitator Superfamily
PFKLECOI_03767 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PFKLECOI_03768 9.5e-71 ywhA K Transcriptional regulator
PFKLECOI_03769 2.7e-25 dmpI 5.3.2.6 G 4-oxalocrotonate tautomerase
PFKLECOI_03770 5.1e-119 ywhC S Peptidase family M50
PFKLECOI_03771 2.6e-94 ywhD S YwhD family
PFKLECOI_03772 0.0 pbpG 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
PFKLECOI_03773 1.4e-158 speE 2.5.1.16 E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
PFKLECOI_03774 1.3e-167 speB 3.5.3.11 E Belongs to the arginase family
PFKLECOI_03776 4.4e-59 V ATPases associated with a variety of cellular activities
PFKLECOI_03779 1.3e-20
PFKLECOI_03780 8.1e-10
PFKLECOI_03782 2.6e-78 S aspartate phosphatase
PFKLECOI_03783 2.7e-191 ywhK CO amine dehydrogenase activity
PFKLECOI_03784 5.6e-245 ywhL CO amine dehydrogenase activity
PFKLECOI_03786 2.3e-248 L Peptidase, M16
PFKLECOI_03787 1.8e-215 2.7.1.26, 2.7.7.2 L Peptidase, M16
PFKLECOI_03788 8.5e-235 mgtA 3.6.3.2 P ATPase, P-type transporting, HAD superfamily, subfamily IC
PFKLECOI_03789 5.7e-132 cbiO V ABC transporter
PFKLECOI_03791 4.9e-270 C Fe-S oxidoreductases
PFKLECOI_03792 1e-07 S Bacteriocin subtilosin A
PFKLECOI_03793 4.7e-73 ywiB S protein conserved in bacteria
PFKLECOI_03794 0.0 argS 6.1.1.19 J Arginyl-tRNA synthetase
PFKLECOI_03795 2.3e-213 narK P COG2223 Nitrate nitrite transporter
PFKLECOI_03796 2e-129 fnr K helix_turn_helix, cAMP Regulatory protein
PFKLECOI_03797 2.8e-139 ywiC S YwiC-like protein
PFKLECOI_03798 4.5e-85 arfM T cyclic nucleotide binding
PFKLECOI_03799 0.0 narG 1.7.5.1 C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
PFKLECOI_03800 2.5e-296 narH 1.7.5.1 C Nitrate reductase, beta
PFKLECOI_03801 3.6e-94 narJ 1.7.5.1 C nitrate reductase
PFKLECOI_03802 1.5e-123 narI 1.7.5.1 C nitrate reductase, gamma
PFKLECOI_03803 3.2e-286 ywiE I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PFKLECOI_03804 0.0 ywjA V ABC transporter
PFKLECOI_03805 4.8e-96 ywjB H RibD C-terminal domain
PFKLECOI_03806 2.7e-42 ywjC
PFKLECOI_03807 6.6e-184 uvsE L Component in a DNA repair pathway. Removal of UV-light damaged nucleotides. Recognizes pyrimidine dimers and cleave a phosphodiester bond immediately 5' to the lesion
PFKLECOI_03808 2.3e-223 clsB I Belongs to the phospholipase D family. Cardiolipin synthase subfamily
PFKLECOI_03809 0.0 fadF C COG0247 Fe-S oxidoreductase
PFKLECOI_03810 4.4e-211 acdA 1.3.8.1, 1.3.8.7 I acyl-CoA dehydrogenase
PFKLECOI_03811 1.1e-49 rpoE K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
PFKLECOI_03812 0.0 pyrG 6.3.4.2 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
PFKLECOI_03813 5.1e-90 ywjG S Domain of unknown function (DUF2529)
PFKLECOI_03814 1.1e-62 spo0F T COG0784 FOG CheY-like receiver
PFKLECOI_03815 7.2e-158 fbaA 4.1.2.13, 4.1.2.29 G Aldolase
PFKLECOI_03816 1.5e-112 tal 2.2.1.2 G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PFKLECOI_03817 8.6e-240 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PFKLECOI_03818 1.9e-175 glpX 3.1.3.11, 3.1.3.37 G fructose-1,6-bisphosphatase
PFKLECOI_03819 2.8e-238 rho K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
PFKLECOI_03820 1.1e-32 rpmE J Binds the 23S rRNA
PFKLECOI_03821 5.4e-104 tdk 2.7.1.21 F thymidine kinase
PFKLECOI_03822 0.0 sfcA 1.1.1.38 C malic enzyme
PFKLECOI_03823 8.6e-160 ywkB S Membrane transport protein
PFKLECOI_03824 7.1e-90 racA K Required for the formation of axial filaments and for anchoring the origin regions at the cell poles in sporulating cells, thus ensuring proper chromosome segregation in the prespore. Binds in a dispersed manner throughout the chromosome but preferentially to sites clustered in the origin portion of the chromosome, causing condensation of the chromosome and its remodeling into an elongated, anchored structure
PFKLECOI_03825 1.2e-67 yaeR E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PFKLECOI_03826 9.5e-192 prfA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PFKLECOI_03827 2.3e-159 prmC 2.1.1.297 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
PFKLECOI_03829 9.8e-56 ywlA S Uncharacterised protein family (UPF0715)
PFKLECOI_03830 6.1e-112 spoIIR S stage II sporulation protein R
PFKLECOI_03831 2.1e-76 ywlB 1.20.4.1, 2.3.1.1 E Belongs to the acetyltransferase family. ArgA subfamily
PFKLECOI_03832 6.2e-196 ywlC 2.7.7.87, 3.1.3.48 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
PFKLECOI_03833 1.7e-91 mntP P Probably functions as a manganese efflux pump
PFKLECOI_03834 1.3e-76 ywlE 3.1.3.48, 3.9.1.2, 5.3.1.6 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PFKLECOI_03835 8.3e-81 rpiB 5.3.1.6 G Ribose 5-phosphate isomerase
PFKLECOI_03836 3.6e-94 ywlG S Belongs to the UPF0340 family
PFKLECOI_03837 2.1e-238 glyA 2.1.2.1 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PFKLECOI_03838 4.7e-114 upp 2.4.2.9 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
PFKLECOI_03839 2.5e-62 atpI S ATP synthase
PFKLECOI_03840 4.6e-129 atpB C it plays a direct role in the translocation of protons across the membrane
PFKLECOI_03841 1.6e-26 atpE C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PFKLECOI_03842 3.8e-45 atpF C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PFKLECOI_03843 5.9e-89 atpH C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PFKLECOI_03844 4.5e-280 atpA 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PFKLECOI_03845 1.1e-150 atpG C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PFKLECOI_03846 1.2e-266 atpD 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PFKLECOI_03847 9.4e-52 atpC C Produces ATP from ADP in the presence of a proton gradient across the membrane
PFKLECOI_03848 5.9e-85 ywmA
PFKLECOI_03849 1.3e-32 ywzB S membrane
PFKLECOI_03850 3.1e-133 ywmB S TATA-box binding
PFKLECOI_03851 1.2e-241 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PFKLECOI_03852 1e-174 spoIID D Stage II sporulation protein D
PFKLECOI_03853 1.7e-122 ywmC S protein containing a von Willebrand factor type A (vWA) domain
PFKLECOI_03854 4.7e-120 ywmD S protein containing a von Willebrand factor type A (vWA) domain
PFKLECOI_03856 2.6e-146 fdhD C Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PFKLECOI_03857 7e-192 moaA 4.1.99.22, 4.6.1.17 H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PFKLECOI_03858 1.3e-103 S response regulator aspartate phosphatase
PFKLECOI_03859 3e-84 ywmF S Peptidase M50
PFKLECOI_03860 3.8e-11 csbD K CsbD-like
PFKLECOI_03861 6.3e-51 ureA 3.5.1.5 E Belongs to the urease gamma subunit family
PFKLECOI_03862 5.9e-64 ureB 3.5.1.5 E Belongs to the urease beta subunit family
PFKLECOI_03863 0.0 ureC 3.5.1.5 E Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family
PFKLECOI_03864 8.2e-64 ywnA K Transcriptional regulator
PFKLECOI_03865 5.8e-112 ywnB S NAD(P)H-binding
PFKLECOI_03866 3.8e-58 ywnC S Family of unknown function (DUF5362)
PFKLECOI_03867 2.9e-142 mta K transcriptional
PFKLECOI_03868 1.2e-277 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PFKLECOI_03869 2.2e-70 ywnF S Family of unknown function (DUF5392)
PFKLECOI_03870 7.5e-09 ywnC S Family of unknown function (DUF5362)
PFKLECOI_03871 5.4e-89 ywnH 2.3.1.183 M COG1247 Sortase and related acyltransferases
PFKLECOI_03872 5.3e-116 spoIIQ M COG0739 Membrane proteins related to metalloendopeptidases
PFKLECOI_03873 6.6e-72 ywnJ S VanZ like family
PFKLECOI_03874 5.9e-103 bcrC 3.6.1.27 I COG0671 Membrane-associated phospholipid phosphatase
PFKLECOI_03875 1.6e-58 nrgB K Belongs to the P(II) protein family
PFKLECOI_03876 4.3e-225 amt P Ammonium transporter
PFKLECOI_03877 4.8e-76
PFKLECOI_03878 2e-103 phzA Q Isochorismatase family
PFKLECOI_03879 2.4e-240 ywoD EGP Major facilitator superfamily
PFKLECOI_03880 6.8e-281 ybbW FH COG1953 Cytosine uracil thiamine allantoin permeases
PFKLECOI_03881 6.1e-231 ywoF P Right handed beta helix region
PFKLECOI_03882 2.7e-211 ywoG EGP Major facilitator Superfamily
PFKLECOI_03883 2.1e-70 ywoH K COG1846 Transcriptional regulators
PFKLECOI_03884 3e-44 spoIIID K Stage III sporulation protein D
PFKLECOI_03885 3.5e-180 mbl D Rod shape-determining protein
PFKLECOI_03886 1.3e-124 flhO N flagellar basal body
PFKLECOI_03887 2.6e-141 flhP N flagellar basal body
PFKLECOI_03888 2.3e-198 S aspartate phosphatase
PFKLECOI_03889 4.6e-82 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
PFKLECOI_03890 3.9e-50 mscL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
PFKLECOI_03891 0.0 ywpD T PhoQ Sensor
PFKLECOI_03892 5.3e-174 M1-574 T Transcriptional regulatory protein, C terminal
PFKLECOI_03893 0.0 M1-568 M cell wall anchor domain
PFKLECOI_03894 1.8e-84 srtA 3.4.22.70 M Sortase family
PFKLECOI_03895 2.4e-66 ywpF S YwpF-like protein
PFKLECOI_03896 6.4e-66 ywpG
PFKLECOI_03897 3.7e-57 ssbB L Single-stranded DNA-binding protein
PFKLECOI_03898 8.8e-139 glcR K COG1349 Transcriptional regulators of sugar metabolism
PFKLECOI_03899 1.1e-153 ywpJ 3.1.3.104 S hydrolases of the HAD superfamily
PFKLECOI_03900 0.0 ywqA L COG0553 Superfamily II DNA RNA helicases, SNF2 family
PFKLECOI_03901 4.6e-307 ywqB S SWIM zinc finger
PFKLECOI_03902 1.2e-17
PFKLECOI_03903 2e-116 ywqC M biosynthesis protein
PFKLECOI_03904 1.1e-119 ywqD 2.7.10.1 D COG0489 ATPases involved in chromosome partitioning
PFKLECOI_03905 1.4e-141 ywqE 3.1.3.48 GM COG4464 Capsular polysaccharide biosynthesis protein
PFKLECOI_03906 3.7e-246 ugd 1.1.1.22 M Belongs to the UDP-glucose GDP-mannose dehydrogenase family
PFKLECOI_03907 6.6e-150 ywqG S Domain of unknown function (DUF1963)
PFKLECOI_03908 4.4e-23 S Domain of unknown function (DUF5082)
PFKLECOI_03909 2.5e-37 ywqI S Family of unknown function (DUF5344)
PFKLECOI_03910 3.5e-242 ywqJ S Pre-toxin TG
PFKLECOI_03911 3.9e-25
PFKLECOI_03912 1.8e-114 nfi 3.1.21.7 L DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA
PFKLECOI_03913 4.2e-161 K Transcriptional regulator
PFKLECOI_03914 1.3e-99 ywqN S NAD(P)H-dependent
PFKLECOI_03916 1.5e-89 ywrA P COG2059 Chromate transport protein ChrA
PFKLECOI_03917 2.4e-104 ywrB P Chromate transporter
PFKLECOI_03918 8e-82 ywrC K Transcriptional regulator
PFKLECOI_03919 6.9e-308 ggt 2.3.2.2, 3.4.19.13 E gamma-glutamyltransferase
PFKLECOI_03920 5e-54 S Domain of unknown function (DUF4181)
PFKLECOI_03921 8.1e-111 ywrF S COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PFKLECOI_03922 3.7e-12
PFKLECOI_03923 1.2e-210 cotH M Spore Coat
PFKLECOI_03924 7.6e-131 cotB
PFKLECOI_03925 1.1e-124 ywrJ
PFKLECOI_03926 5.5e-220 ywrK P Involved in arsenical resistance. Thought to form the channel of an arsenite pump
PFKLECOI_03927 1.1e-169 alsR K LysR substrate binding domain
PFKLECOI_03928 0.0 alsS 2.2.1.6 EH Belongs to the TPP enzyme family
PFKLECOI_03929 1.3e-145 budA 4.1.1.5 H Alpha-acetolactate decarboxylase
PFKLECOI_03930 1.5e-97 ywrO S NADPH-quinone reductase (modulator of drug activity B)
PFKLECOI_03931 8e-48 ywsA S Protein of unknown function (DUF3892)
PFKLECOI_03932 8.7e-93 batE T Sh3 type 3 domain protein
PFKLECOI_03933 1.1e-159 rbsB G COG1879 ABC-type sugar transport system, periplasmic component
PFKLECOI_03934 2.1e-153 rbsC G Belongs to the binding-protein-dependent transport system permease family
PFKLECOI_03935 1.1e-273 rbsA 3.6.3.17 G Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system
PFKLECOI_03936 1.4e-63 rbsD 5.4.99.62 G Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose
PFKLECOI_03937 2.7e-160 rbsK 2.7.1.15, 2.7.1.4 H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PFKLECOI_03938 9.3e-178 rbsR K transcriptional
PFKLECOI_03939 6.1e-224 murD 6.3.2.9 M COG0769 UDP-N-acetylmuramyl tripeptide synthase
PFKLECOI_03940 8.6e-70 pgsC S biosynthesis protein
PFKLECOI_03941 1.7e-218 capA M enzyme of poly-gamma-glutamate biosynthesis (capsule formation)
PFKLECOI_03942 3.6e-21 ywtC
PFKLECOI_03943 1e-238 pgdS CBM50 M COG0791 Cell wall-associated hydrolases (invasion-associated proteins)
PFKLECOI_03944 2.9e-159 ywtE 3.1.3.104 S hydrolases of the HAD superfamily
PFKLECOI_03945 1.7e-168 ywtF K Transcriptional regulator
PFKLECOI_03946 4.1e-248 ywtG EGP Major facilitator Superfamily
PFKLECOI_03947 7.6e-216 gerAC S Spore germination protein
PFKLECOI_03948 7.5e-200 gerBB E Spore germination protein
PFKLECOI_03949 3.9e-265 gerBA EG Spore germination protein
PFKLECOI_03950 1.1e-188 pmi 5.3.1.8 G mannose-6-phosphate isomerase
PFKLECOI_03951 2e-214 atl 3.2.1.96, 3.5.1.28 GH73 G Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
PFKLECOI_03952 2.5e-192 tarL 2.7.8.14, 2.7.8.47 M CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PFKLECOI_03953 1.5e-89 2.7.8.46 M CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PFKLECOI_03954 6.2e-148 tarJ 1.1.1.137, 1.1.1.303, 1.1.1.4, 1.1.1.405 E Catalyzes the NADPH dependent reduction of D-ribulose 5- phosphate to D-ribitol 5-phosphate
PFKLECOI_03955 2.6e-105 ispD 1.1.1.405, 2.7.7.40, 2.7.7.60, 4.6.1.12 I Catalyzes the transfer of the cytidylyl group of CTP to D-ribitol 5-phosphate
PFKLECOI_03956 1.5e-105 tagB 2.7.8.14, 2.7.8.44, 2.7.8.47 M glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
PFKLECOI_03957 9.2e-88 tagA 2.4.1.187 GT26 M Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid
PFKLECOI_03958 2.1e-56 tagD 2.7.7.15, 2.7.7.39 IM Cytidylyltransferase
PFKLECOI_03959 5.3e-135 tagF 2.7.8.12 M glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
PFKLECOI_03960 1.3e-111 ggaA M Glycosyltransferase like family 2
PFKLECOI_03961 1.1e-87
PFKLECOI_03962 2.7e-131 M Glycosyltransferase like family 2
PFKLECOI_03963 3.3e-148 M CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PFKLECOI_03964 8.5e-132 tagG GM Transport permease protein
PFKLECOI_03965 2.1e-267 tagH 3.6.3.38, 3.6.3.40 GM Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system
PFKLECOI_03966 2e-163 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
PFKLECOI_03967 6.3e-23 tagE 2.4.1.52 GT4 M Glycosyl transferases group 1
PFKLECOI_03968 5.4e-100 tagE 2.4.1.52 GT4 M Glycosyl transferases group 1
PFKLECOI_03969 2.1e-88 M Glycosyltransferase like family 2
PFKLECOI_03970 2.5e-214 mnaA 5.1.3.14 M Belongs to the UDP-N-acetylglucosamine 2-epimerase family
PFKLECOI_03971 2.7e-158 lytR K May catalyze the final step in cell wall teichoic acid biosynthesis, the transfer of the anionic cell wall polymers (APs) from their lipid-linked precursor to the cell wall peptidoglycan (PG)
PFKLECOI_03972 7.7e-12
PFKLECOI_03973 0.0 lytB 3.5.1.28 D Stage II sporulation protein
PFKLECOI_03974 2.4e-209 lytC 3.5.1.28 M n-acetylmuramoyl-L-alanine amidase
PFKLECOI_03975 1.5e-94 M Glycosyltransferase like family 2
PFKLECOI_03976 1.3e-111 tuaA M COG2148 Sugar transferases involved in lipopolysaccharide synthesis
PFKLECOI_03977 9.7e-248 wzxC S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
PFKLECOI_03978 3.1e-220 tuaC 2.4.1.21, 3.2.1.1 GH13,GT4,GT5 GM Teichuronic acid
PFKLECOI_03979 5.8e-258 tuaD 1.1.1.22 M Belongs to the UDP-glucose GDP-mannose dehydrogenase family
PFKLECOI_03980 1.8e-262 tuaE M Teichuronic acid biosynthesis protein
PFKLECOI_03981 9.5e-113 tuaF M protein involved in exopolysaccharide biosynthesis
PFKLECOI_03982 2.1e-145 tuaG GT2 M Glycosyltransferase like family 2
PFKLECOI_03983 1.1e-233 tuaH M Teichuronic acid biosynthesis glycosyltransferase tuaH
PFKLECOI_03984 2.6e-181 tagO 2.7.8.33, 2.7.8.35 M COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase UDP-N-acetylglucosamine-1-phosphate transferase
PFKLECOI_03985 6e-163 yvhJ K Transcriptional regulator
PFKLECOI_03986 2e-120 yvyE 3.4.13.9 S Domain of unknown function (DUF1949)
PFKLECOI_03987 5.1e-183 degS 2.7.13.3 T Member of the two-component regulatory system DegS DegU, which plays an important role in the transition growth phase
PFKLECOI_03988 2e-126 degU KT COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
PFKLECOI_03989 2.1e-154 degV S protein conserved in bacteria
PFKLECOI_03990 2.4e-267 comFA L COG4098 Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
PFKLECOI_03991 3.7e-45 comFB S Late competence development protein ComFB
PFKLECOI_03992 1.2e-126 comFC S Phosphoribosyl transferase domain
PFKLECOI_03993 7e-74 yvyF S flagellar protein
PFKLECOI_03994 1.6e-39 flgM KNU Negative regulator of flagellin synthesis
PFKLECOI_03995 2.4e-78 flgN NOU FlgN protein
PFKLECOI_03996 1.6e-264 flgK N flagellar hook-associated protein
PFKLECOI_03997 7.8e-155 flgL N Belongs to the bacterial flagellin family
PFKLECOI_03998 5.7e-50 yviE
PFKLECOI_03999 2.7e-73 fliW S Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
PFKLECOI_04000 5.7e-30 csrA T Could accelerate the degradation of some genes transcripts potentially through selective RNA binding

eggNOG-mapper v2 (Database: eggNOG v5.0, Jul. 2018 release)