ORF_ID e_value Gene_name EC_number CAZy COGs Description
HEGKEINC_00001 1.3e-257 dnaA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HEGKEINC_00002 6.3e-202 dnaN 2.7.7.7 L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
HEGKEINC_00003 1.1e-29 yyzM S Protein conserved in bacteria
HEGKEINC_00004 1.9e-203 ychF J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
HEGKEINC_00005 1.4e-104 pth 3.1.1.29 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
HEGKEINC_00006 0.0 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HEGKEINC_00007 1.7e-39 yabO J Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
HEGKEINC_00008 2.7e-61 divIC D Septum formation initiator
HEGKEINC_00010 1.3e-240 XK27_09285 3.5.2.6 V Beta-lactamase enzyme family
HEGKEINC_00011 5e-240 tilS 2.4.2.8, 6.3.4.19 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
HEGKEINC_00012 3.4e-97 hpt 2.4.2.8, 6.3.4.19 F Belongs to the purine pyrimidine phosphoribosyltransferase family
HEGKEINC_00013 0.0 ftsH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEGKEINC_00014 1.1e-136 L Transposase
HEGKEINC_00024 1.3e-140 mreC M Involved in formation and maintenance of cell shape
HEGKEINC_00025 8.2e-88 mreD M Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HEGKEINC_00026 5.5e-94 usp 3.5.1.28 CBM50 S CHAP domain
HEGKEINC_00027 1.2e-174 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HEGKEINC_00028 5.9e-219 araT 2.6.1.1 E Aminotransferase
HEGKEINC_00029 1.6e-143 recO L Involved in DNA repair and RecF pathway recombination
HEGKEINC_00030 3.9e-179 plsX 2.3.1.15 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
HEGKEINC_00031 4.2e-34 acpP1 IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEGKEINC_00032 1.2e-129 purC 4.1.1.21, 4.3.2.2, 6.3.2.6 F Belongs to the SAICAR synthetase family
HEGKEINC_00033 0.0 purL 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HEGKEINC_00034 1.3e-276 purF 2.4.2.14 F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HEGKEINC_00035 3.7e-185 purM 6.3.3.1, 6.3.4.13 F Phosphoribosylformylglycinamidine cyclo-ligase
HEGKEINC_00036 1.4e-101 purN 2.1.2.2 F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HEGKEINC_00037 7.3e-294 purH 2.1.2.3, 3.5.4.10 F Bifunctional purine biosynthesis protein PurH
HEGKEINC_00038 1e-90 L transposase activity
HEGKEINC_00039 9.3e-36 L transposition
HEGKEINC_00040 2e-32 L Integrase core domain protein
HEGKEINC_00041 2.3e-161 S CHAP domain
HEGKEINC_00042 2e-241 purD 6.3.4.13 F Belongs to the GARS family
HEGKEINC_00043 4.9e-76 purE 5.4.99.18 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HEGKEINC_00044 8.5e-204 purK 6.3.4.18 F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HEGKEINC_00045 4.3e-138 1.1.1.169 H Ketopantoate reductase
HEGKEINC_00046 2.8e-23
HEGKEINC_00047 2.3e-136 J Domain of unknown function (DUF4041)
HEGKEINC_00048 8.7e-248 purB 4.3.2.2 F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HEGKEINC_00049 0.0 argS 6.1.1.19 J Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
HEGKEINC_00050 2.9e-210 sip L Belongs to the 'phage' integrase family
HEGKEINC_00051 2.2e-14 K Cro/C1-type HTH DNA-binding domain
HEGKEINC_00052 8e-20 K TRANSCRIPTIONal
HEGKEINC_00056 9e-22
HEGKEINC_00057 1.4e-145 KL Phage plasmid primase P4 family
HEGKEINC_00058 1.5e-280 S DNA primase
HEGKEINC_00060 3.5e-13
HEGKEINC_00062 2.2e-18 L RePlication protein
HEGKEINC_00064 2e-171 aaxC E Arginine ornithine antiporter
HEGKEINC_00065 9.1e-122 4.1.1.22 H Histidine carboxylase PI chain
HEGKEINC_00067 9.1e-46 3.1.21.3 V Type I restriction modification DNA specificity domain
HEGKEINC_00068 8.2e-70 argR K Regulates arginine biosynthesis genes
HEGKEINC_00069 1e-57 ymcA 3.6.3.21 S Belongs to the UPF0342 family
HEGKEINC_00070 0.0 mutS L that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HEGKEINC_00071 7e-34 S Protein of unknown function (DUF3021)
HEGKEINC_00072 1.2e-61 KT phosphorelay signal transduction system
HEGKEINC_00074 0.0 mutL L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HEGKEINC_00076 7.8e-103 ruvA 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
HEGKEINC_00077 1.9e-106 tag 3.2.2.20 L 3-methyladenine DNA glycosylase
HEGKEINC_00078 6.5e-232 cinA 3.5.1.42 S Belongs to the CinA family
HEGKEINC_00079 4.7e-205 recA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HEGKEINC_00080 2.3e-66 spxA_2 1.20.4.1 P Belongs to the ArsC family
HEGKEINC_00083 1.9e-07
HEGKEINC_00088 0.0 polC 2.7.7.7 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HEGKEINC_00089 8.9e-234 pepS E COG2309 Leucyl aminopeptidase (aminopeptidase T)
HEGKEINC_00090 5.5e-36 XK27_02060 S Transglycosylase associated protein
HEGKEINC_00091 2.6e-55 badR K DNA-binding transcription factor activity
HEGKEINC_00092 3.5e-97 S reductase
HEGKEINC_00093 2.3e-59 L Integrase core domain protein
HEGKEINC_00095 7.9e-76 yocD 3.4.17.13 V carboxypeptidase activity
HEGKEINC_00096 4.6e-91 yocD 3.4.17.13 V proteins, homologs of microcin C7 resistance protein MccF
HEGKEINC_00098 1.3e-137 rpsB J Belongs to the universal ribosomal protein uS2 family
HEGKEINC_00099 1.7e-182 tsf J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HEGKEINC_00100 1.1e-83 S Putative small multi-drug export protein
HEGKEINC_00101 6.2e-76 ctsR K Belongs to the CtsR family
HEGKEINC_00102 0.0 clpC O Belongs to the ClpA ClpB family
HEGKEINC_00103 7e-127 dacA 3.4.16.4 M Belongs to the peptidase S11 family
HEGKEINC_00104 2e-59 dacA 3.4.16.4 M Belongs to the peptidase S11 family
HEGKEINC_00105 1.4e-231 dacA 3.4.16.4 M Belongs to the peptidase S11 family
HEGKEINC_00106 0.0 pnp 2.7.7.8 J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
HEGKEINC_00107 6.9e-144 S SseB protein N-terminal domain
HEGKEINC_00108 1.1e-112 cysE 2.3.1.30 E serine acetyltransferase
HEGKEINC_00109 1.7e-259 cysS 6.1.1.16, 6.3.1.13 J Belongs to the class-I aminoacyl-tRNA synthetase family
HEGKEINC_00110 2.7e-67 mrnC J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HEGKEINC_00113 5.7e-135 trmH 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEGKEINC_00114 3.5e-91 yacP S RNA-binding protein containing a PIN domain
HEGKEINC_00115 3.4e-155 degV S DegV family
HEGKEINC_00116 1.8e-31 K helix-turn-helix
HEGKEINC_00117 1.6e-182 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HEGKEINC_00118 2e-79 rplM J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HEGKEINC_00119 9.5e-65 rpsI J Belongs to the universal ribosomal protein uS9 family
HEGKEINC_00120 1.5e-35 K sequence-specific DNA binding
HEGKEINC_00122 0.0 S Lantibiotic dehydratase, C terminus
HEGKEINC_00123 2.4e-231 spaC2 V Lanthionine synthetase C family protein
HEGKEINC_00124 5.6e-183 EGP Major facilitator Superfamily
HEGKEINC_00125 5.9e-24 3.6.4.12
HEGKEINC_00126 5.9e-91 3.6.4.12 K Divergent AAA domain protein
HEGKEINC_00127 8.2e-224 int L Belongs to the 'phage' integrase family
HEGKEINC_00128 1.8e-38 S Helix-turn-helix domain
HEGKEINC_00129 4.9e-173
HEGKEINC_00131 6.3e-74 isp2 S pathogenesis
HEGKEINC_00132 6.2e-128 tnp L Transposase IS66 family
HEGKEINC_00133 3.3e-225 capA M Bacterial capsule synthesis protein
HEGKEINC_00134 3.6e-39 gcvR T UPF0237 protein
HEGKEINC_00135 1.9e-242 XK27_08635 S UPF0210 protein
HEGKEINC_00136 2.2e-38 ais G alpha-ribazole phosphatase activity
HEGKEINC_00137 1.6e-143 vanY 3.4.17.14 M D-alanyl-D-alanine carboxypeptidase
HEGKEINC_00138 1.3e-102 acmA 3.2.1.17 NU amidase activity
HEGKEINC_00139 5.3e-198 hrcA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
HEGKEINC_00140 1.3e-71 grpE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HEGKEINC_00141 7.5e-298 dnaK O Heat shock 70 kDa protein
HEGKEINC_00142 4.2e-190 dnaJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
HEGKEINC_00143 8.5e-139 truA 5.4.99.12 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
HEGKEINC_00144 6.2e-137 thiD 2.7.1.35, 2.7.1.49, 2.7.4.7 H phosphomethylpyrimidine kinase
HEGKEINC_00145 1.7e-60 hmpT S membrane
HEGKEINC_00147 9.9e-19 S Domain of unknown function (DUF4649)
HEGKEINC_00148 2.8e-52 amd 3.5.1.47 E Peptidase dimerisation domain
HEGKEINC_00149 2.7e-232 cfa 2.1.1.317, 2.1.1.79 M cyclopropane-fatty-acyl-phospholipid synthase
HEGKEINC_00150 6.5e-87
HEGKEINC_00151 1.6e-77 sigH K DNA-templated transcription, initiation
HEGKEINC_00152 3e-148 ykuT M mechanosensitive ion channel
HEGKEINC_00153 6.4e-219 tig D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
HEGKEINC_00154 4.8e-73 rpoE K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
HEGKEINC_00155 7.6e-310 pyrG 6.3.4.2 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
HEGKEINC_00156 1.3e-84 XK27_03960 S Protein of unknown function (DUF3013)
HEGKEINC_00157 3.7e-81 mutT3 3.6.1.13, 3.6.1.55 L NUDIX domain
HEGKEINC_00158 5.9e-177 prmA J Ribosomal protein L11 methyltransferase
HEGKEINC_00159 4.4e-135 rsmE 2.1.1.193 J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
HEGKEINC_00160 0.0 cpdB 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
HEGKEINC_00161 2.4e-83 nrdI F Belongs to the NrdI family
HEGKEINC_00162 0.0 relA 2.7.6.5 KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEGKEINC_00163 7.4e-74 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
HEGKEINC_00164 1.4e-09 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
HEGKEINC_00165 2e-27 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
HEGKEINC_00166 2.1e-58 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
HEGKEINC_00167 3.9e-46 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
HEGKEINC_00168 1.7e-237 ilvA 4.3.1.19 E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HEGKEINC_00169 3.3e-112 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
HEGKEINC_00170 1.1e-113 fnr5 K Catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
HEGKEINC_00171 6.5e-202 yhjX P Major Facilitator
HEGKEINC_00172 9.2e-43 rpsO J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HEGKEINC_00173 5e-94 V VanZ like family
HEGKEINC_00175 1e-123 glnQ E abc transporter atp-binding protein
HEGKEINC_00176 1.8e-276 glnP P ABC transporter
HEGKEINC_00177 1.5e-152 uppP 3.6.1.27 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
HEGKEINC_00178 2.3e-136 mecA NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
HEGKEINC_00179 1.1e-185 tagO 2.7.8.33, 2.7.8.35 M transferase
HEGKEINC_00180 9.5e-144 sufC O ABC-type transport system involved in Fe-S cluster assembly, ATPase component
HEGKEINC_00181 6.3e-235 sufD O assembly protein SufD
HEGKEINC_00182 7.7e-238 sufS 2.8.1.7, 4.4.1.16 E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HEGKEINC_00183 2.5e-74 nifU C SUF system FeS assembly protein, NifU family
HEGKEINC_00184 2.2e-273 sufB O assembly protein SufB
HEGKEINC_00185 7e-10 oppA E ABC transporter substrate-binding protein
HEGKEINC_00186 3.3e-138 oppA E ABC transporter substrate-binding protein
HEGKEINC_00187 4.2e-27 oppB P ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEGKEINC_00188 6.6e-11 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEGKEINC_00189 1.7e-33 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEGKEINC_00190 9.8e-40 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEGKEINC_00191 3e-27 oppD P Belongs to the ABC transporter superfamily
HEGKEINC_00192 2.5e-32 oppD P Belongs to the ABC transporter superfamily
HEGKEINC_00193 1.7e-61 oppD P Belongs to the ABC transporter superfamily
HEGKEINC_00194 3.1e-43 oppD P Belongs to the ABC transporter superfamily
HEGKEINC_00195 1.1e-60 oppF P Belongs to the ABC transporter superfamily
HEGKEINC_00196 1.2e-91 oppF P Belongs to the ABC transporter superfamily
HEGKEINC_00199 1.9e-158 hslO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HEGKEINC_00200 7.4e-183 dus J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HEGKEINC_00201 4.9e-222 EGP Major facilitator Superfamily
HEGKEINC_00202 3.1e-72 adcR K transcriptional
HEGKEINC_00203 2.2e-136 adcC P ABC transporter, ATP-binding protein
HEGKEINC_00204 4.6e-130 adcB P ABC transporter (Permease
HEGKEINC_00205 1.4e-162 mleP2 S Transporter, auxin efflux carrier (AEC) family protein
HEGKEINC_00206 5.6e-65 ptsG 2.7.1.199, 2.7.1.208 G pts system
HEGKEINC_00207 7.8e-150 ptsG 2.7.1.199, 2.7.1.208, 2.7.1.211 G pts system
HEGKEINC_00208 1.4e-105 ptsG 2.7.1.199, 2.7.1.208, 2.7.1.211 G phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1
HEGKEINC_00209 6.8e-158 rgfB 3.1.3.90 L Endonuclease/Exonuclease/phosphatase family
HEGKEINC_00210 2.8e-257 pgi 5.3.1.9 G Belongs to the GPI family
HEGKEINC_00211 1.9e-127 yeeN K transcriptional regulatory protein
HEGKEINC_00212 9.8e-50 yajC U protein transport
HEGKEINC_00213 1.1e-141 uppS 2.5.1.31 H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HEGKEINC_00214 1.7e-145 cdsA 2.7.7.41 S Belongs to the CDS family
HEGKEINC_00215 5.5e-231 rseP 3.4.21.107, 3.4.21.116 M zinc metalloprotease
HEGKEINC_00216 0.0 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
HEGKEINC_00217 0.0 WQ51_06230 S ABC transporter substrate binding protein
HEGKEINC_00218 5.2e-142 cmpC S abc transporter atp-binding protein
HEGKEINC_00219 1.3e-42 groS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HEGKEINC_00220 4.1e-287 groL O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
HEGKEINC_00221 4.4e-37 L Transposase
HEGKEINC_00222 6.4e-18 L transposase activity
HEGKEINC_00225 4.7e-43
HEGKEINC_00226 3.4e-55 S TM2 domain
HEGKEINC_00227 1.8e-164 rluA 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
HEGKEINC_00228 0.0 pbp2A 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
HEGKEINC_00229 5.7e-25 secE U Belongs to the SecE SEC61-gamma family
HEGKEINC_00230 8.4e-96 nusG K Participates in transcription elongation, termination and antitermination
HEGKEINC_00231 4.6e-85 3.1.3.27, 3.1.3.4, 3.1.3.81, 3.6.1.27 I phosphatidate phosphatase activity
HEGKEINC_00232 1.7e-45 cof Q phosphatase activity
HEGKEINC_00233 1.9e-31 cof Q phosphatase activity
HEGKEINC_00234 7.3e-83 glcR K transcriptional regulator (DeoR family)
HEGKEINC_00235 0.0 leuS 6.1.1.4 J Belongs to the class-I aminoacyl-tRNA synthetase family
HEGKEINC_00236 3.5e-71 K transcriptional
HEGKEINC_00237 2.2e-232 S COG1073 Hydrolases of the alpha beta superfamily
HEGKEINC_00238 3.4e-277 pncB 6.3.4.21 H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HEGKEINC_00239 4.8e-151 nadE 6.3.1.5 H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
HEGKEINC_00240 3.2e-77 yhaI L Membrane
HEGKEINC_00241 1.7e-259 pepC 3.4.22.40 E aminopeptidase
HEGKEINC_00242 6.8e-69
HEGKEINC_00243 1.7e-28 potC P Binding-protein-dependent transport system inner membrane component
HEGKEINC_00244 8.9e-206 potD P spermidine putrescine ABC transporter
HEGKEINC_00245 3.1e-268 clcA P Chloride transporter, ClC family
HEGKEINC_00246 0.0 prtS 3.4.21.96 O Belongs to the peptidase S8 family
HEGKEINC_00247 1.9e-21 L Helix-turn-helix domain
HEGKEINC_00248 1.1e-82 L Helix-turn-helix domain
HEGKEINC_00249 9.8e-163 L Integrase core domain protein
HEGKEINC_00250 1.6e-249 L Transposase
HEGKEINC_00251 0.0 ponA 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
HEGKEINC_00252 2.5e-109 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
HEGKEINC_00253 3.1e-95 ypsA S Belongs to the UPF0398 family
HEGKEINC_00254 2.5e-50 gpsB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
HEGKEINC_00255 1.5e-222 rlmL 2.1.1.173, 2.1.1.264 L Belongs to the methyltransferase superfamily
HEGKEINC_00256 2.5e-296 mapZ D Early cell division protein that marks the future cell division site and supports proper FtsZ ring positioning
HEGKEINC_00257 0.0 snf 2.7.11.1 L Superfamily II DNA RNA helicases, SNF2 family'
HEGKEINC_00258 2.5e-23
HEGKEINC_00259 2.6e-255 mpl 6.3.2.4, 6.3.2.45, 6.3.2.8 M Belongs to the MurCDEF family
HEGKEINC_00260 7.3e-80 XK27_09675 K -acetyltransferase
HEGKEINC_00261 0.0 mltG ADL Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HEGKEINC_00262 4.5e-68 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
HEGKEINC_00263 5.2e-59 L Integrase core domain protein
HEGKEINC_00264 2.9e-165 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HEGKEINC_00265 7e-46 acyP 3.6.1.7 C Belongs to the acylphosphatase family
HEGKEINC_00266 6.4e-131 spoU 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEGKEINC_00267 4.7e-93 XK27_09705 6.1.1.14 S HD superfamily hydrolase
HEGKEINC_00268 1.5e-97 ybhL S Belongs to the BI1 family
HEGKEINC_00271 2.8e-243 lysA 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
HEGKEINC_00272 1.4e-90 K transcriptional regulator
HEGKEINC_00273 7.6e-36 yneF S UPF0154 protein
HEGKEINC_00274 1.3e-148 murI 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
HEGKEINC_00275 3.2e-186 rdgB 3.6.1.66, 5.1.1.3 F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HEGKEINC_00276 3.5e-99 XK27_09740 S Phosphoesterase
HEGKEINC_00277 5.4e-86 ykuL S CBS domain
HEGKEINC_00278 3.7e-137 xerD L tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site
HEGKEINC_00279 3.1e-122 scpA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HEGKEINC_00280 3e-99 scpB D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HEGKEINC_00281 6.1e-140 rluB 5.4.99.19, 5.4.99.21, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
HEGKEINC_00282 1.2e-39 yidD S Could be involved in insertion of integral membrane proteins into the membrane
HEGKEINC_00283 4.6e-258 trkH P Cation transport protein
HEGKEINC_00284 1.5e-247 trkA P Potassium transporter peripheral membrane component
HEGKEINC_00285 7.9e-96 trmL 2.1.1.207 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
HEGKEINC_00286 6.4e-91 ribU U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HEGKEINC_00287 8.3e-114 bcrC 3.6.1.27 I Membrane-associated phospholipid phosphatase
HEGKEINC_00288 9.5e-161 K sequence-specific DNA binding
HEGKEINC_00289 1.9e-33 V protein secretion by the type I secretion system
HEGKEINC_00290 3.4e-62 V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
HEGKEINC_00291 1.1e-36 V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
HEGKEINC_00292 6.4e-67 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
HEGKEINC_00293 3.7e-22 yhaI L Membrane
HEGKEINC_00294 1.4e-54 S Domain of unknown function (DUF4173)
HEGKEINC_00295 6.8e-95 ureI S AmiS/UreI family transporter
HEGKEINC_00296 7.6e-46 ureA 3.5.1.5 E Belongs to the urease gamma subunit family
HEGKEINC_00297 7.8e-54 ureB 3.5.1.5 E Belongs to the urease beta subunit family
HEGKEINC_00298 0.0 ureC 3.5.1.5 E Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family
HEGKEINC_00299 6.6e-78 ureE O enzyme active site formation
HEGKEINC_00300 5.3e-130 ureF O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
HEGKEINC_00301 9.5e-112 ureG KO Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HEGKEINC_00302 1.3e-159 ureD O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
HEGKEINC_00303 2.7e-177 cbiM P PDGLE domain
HEGKEINC_00304 1.1e-136 P cobalt transport protein
HEGKEINC_00305 1.6e-131 cbiO P ABC transporter
HEGKEINC_00306 5.3e-153 ET amino acid transport
HEGKEINC_00307 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HEGKEINC_00308 0.0 3.3.1.1, 3.6.1.55, 3.6.1.67 F NUDIX domain
HEGKEINC_00309 3.8e-205 EGP Transmembrane secretion effector
HEGKEINC_00310 4e-153 ET amino acid transport
HEGKEINC_00311 3.7e-165 metQ M Belongs to the NlpA lipoprotein family
HEGKEINC_00312 7.1e-86 dapE 3.5.1.18 E COG0624, acetylornithine deacetylase succinyl-diaminopimelate desuccinylase and related deacylases
HEGKEINC_00313 1.4e-62 dapE 3.5.1.18 E succinyl-diaminopimelate desuccinylase activity
HEGKEINC_00314 1e-63 dapE 3.5.1.18 E succinyl-diaminopimelate desuccinylase activity
HEGKEINC_00315 9.8e-189 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HEGKEINC_00316 8.8e-98 metI P ABC transporter (Permease
HEGKEINC_00317 6.1e-211 sstT E Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HEGKEINC_00318 2.9e-159 salL 2.5.1.63, 2.5.1.94 S S-adenosyl-l-methionine hydroxide adenosyltransferase
HEGKEINC_00319 8e-94 S UPF0397 protein
HEGKEINC_00320 0.0 ykoD P abc transporter atp-binding protein
HEGKEINC_00321 1.2e-149 cbiQ P cobalt transport
HEGKEINC_00322 0.0 tkt 2.2.1.1 G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HEGKEINC_00323 1.4e-11 ulaG S L-ascorbate 6-phosphate lactonase
HEGKEINC_00324 1.4e-121 ktrA P COG0569 K transport systems, NAD-binding component
HEGKEINC_00325 1.5e-242 P COG0168 Trk-type K transport systems, membrane components
HEGKEINC_00326 1.1e-130 rsmG 2.1.1.170 J Ribosomal RNA small subunit methyltransferase G
HEGKEINC_00327 2.1e-91 yceD K metal-binding, possibly nucleic acid-binding protein
HEGKEINC_00328 1.8e-122 T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HEGKEINC_00329 2.8e-282 T PhoQ Sensor
HEGKEINC_00330 4.7e-82 nrdR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HEGKEINC_00331 6.5e-218 dnaB L Replication initiation and membrane attachment
HEGKEINC_00332 5.2e-167 dnaI L Primosomal protein DnaI
HEGKEINC_00333 2.6e-247 der 1.1.1.399, 1.1.1.95 S GTPase that plays an essential role in the late steps of ribosome biogenesis
HEGKEINC_00335 1.2e-34
HEGKEINC_00336 6.7e-14 yrdC 3.5.1.19 Q isochorismatase
HEGKEINC_00337 3e-27 L Integrase core domain protein
HEGKEINC_00338 2.8e-230 serS 6.1.1.11 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HEGKEINC_00339 6.5e-63 manO S protein conserved in bacteria
HEGKEINC_00340 1.9e-169 manN G PTS system mannose fructose sorbose family IID component
HEGKEINC_00341 1.6e-117 manM G pts system
HEGKEINC_00342 1.3e-174 manL 2.7.1.191 G pts system
HEGKEINC_00343 1.5e-140 XK27_00940 1.2.1.70, 3.5.1.9 S Metal-dependent hydrolase
HEGKEINC_00344 1e-153 yitU 3.1.3.104 S hydrolases of the HAD superfamily
HEGKEINC_00345 1.9e-248 pbuO S permease
HEGKEINC_00346 1.4e-77 ydiB 2.7.1.221, 5.1.1.1 M ATPase or kinase
HEGKEINC_00347 2.4e-92 XK27_05885 2.3.1.82 M Acetyltransferase GNAT Family
HEGKEINC_00348 1.2e-219 brpA K Transcriptional
HEGKEINC_00349 3.9e-81 rimP S Required for maturation of 30S ribosomal subunits
HEGKEINC_00350 3.1e-212 nusA K Participates in both transcription termination and antitermination
HEGKEINC_00351 1e-47 ylxR K Nucleic-acid-binding protein implicated in transcription termination
HEGKEINC_00352 1.4e-41 ylxQ J ribosomal protein
HEGKEINC_00353 0.0 infB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HEGKEINC_00354 1.7e-57 rbfA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HEGKEINC_00355 1.8e-45 yvdD 3.2.2.10 S Belongs to the LOG family
HEGKEINC_00357 3.6e-48 femA 2.3.2.10, 2.3.2.16, 2.3.2.17, 2.3.2.18 V protein involved in methicillin resistance
HEGKEINC_00358 6e-157 femA 2.3.2.10, 2.3.2.16, 2.3.2.17, 2.3.2.18 V protein involved in methicillin resistance
HEGKEINC_00359 4.9e-276 murE 6.3.2.13, 6.3.2.7 M to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HEGKEINC_00360 4.5e-283 ytgP S Membrane protein involved in the export of O-antigen and teichoic acid
HEGKEINC_00361 3.3e-96 pacL 3.6.3.8, 3.6.3.9 P cation transport ATPase
HEGKEINC_00362 1.8e-201 metB 2.5.1.48, 4.4.1.8 E cystathionine
HEGKEINC_00363 1e-223 malY 4.4.1.8 E COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
HEGKEINC_00365 4.4e-112 upp 2.4.2.9 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HEGKEINC_00366 2.9e-105 clpP 3.4.21.92 OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
HEGKEINC_00367 3.4e-74 ylbF S Belongs to the UPF0342 family
HEGKEINC_00368 7.1e-46 ylbG S UPF0298 protein
HEGKEINC_00369 1.1e-212 livJ E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component
HEGKEINC_00370 1.9e-145 livH E Belongs to the binding-protein-dependent transport system permease family
HEGKEINC_00371 1.4e-138 livM E Belongs to the binding-protein-dependent transport system permease family
HEGKEINC_00372 9.6e-138 livG E COG0411 ABC-type branched-chain amino acid transport systems, ATPase component
HEGKEINC_00373 9.6e-124 livF E COG0410 ABC-type branched-chain amino acid transport systems, ATPase component
HEGKEINC_00374 2.8e-70 acuB S IMP dehydrogenase activity
HEGKEINC_00375 3.3e-43 acuB S IMP dehydrogenase activity
HEGKEINC_00376 2.2e-168 cysK 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
HEGKEINC_00377 6.3e-111 yvyE 3.4.13.9 S YigZ family
HEGKEINC_00378 5.3e-253 comFA L Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HEGKEINC_00379 1.7e-122 comFC S Competence protein
HEGKEINC_00380 2.1e-94 hpf J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HEGKEINC_00385 2.1e-166 ppaC 3.6.1.1 C inorganic pyrophosphatase
HEGKEINC_00386 6.4e-108 S Domain of unknown function (DUF1803)
HEGKEINC_00387 7.8e-102 ygaC J Belongs to the UPF0374 family
HEGKEINC_00388 1.2e-130 recX 2.4.1.337 GT4 S Regulatory protein RecX
HEGKEINC_00389 1.5e-258 rumA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HEGKEINC_00390 8e-193 asnA 6.3.1.1 E aspartate--ammonia ligase
HEGKEINC_00391 2.4e-256 lysC 2.7.2.4 E Belongs to the aspartokinase family
HEGKEINC_00392 1.9e-115 S Haloacid dehalogenase-like hydrolase
HEGKEINC_00393 2.4e-139 phaB 5.3.3.14, 5.3.3.18 I Belongs to the enoyl-CoA hydratase isomerase family
HEGKEINC_00394 4e-72 marR K Transcriptional regulator, MarR family
HEGKEINC_00395 2.3e-173 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEGKEINC_00396 8.2e-29 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEGKEINC_00397 5.8e-172 fabK 1.3.1.9 S 2-Nitropropane dioxygenase
HEGKEINC_00398 8.5e-165 fabD 2.3.1.39 I Malonyl CoA-acyl carrier protein transacylase
HEGKEINC_00399 1.6e-126 IQ reductase
HEGKEINC_00400 2.6e-233 fabF 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
HEGKEINC_00401 7.7e-56 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
HEGKEINC_00402 1.5e-71 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
HEGKEINC_00403 4.8e-257 accC 6.3.4.14, 6.4.1.2 I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
HEGKEINC_00404 1.7e-159 accD 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HEGKEINC_00405 3e-139 accA 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
HEGKEINC_00406 4.7e-90 luxS 4.4.1.21 H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
HEGKEINC_00407 9.9e-64 tnp L Transposase
HEGKEINC_00408 2.3e-214 gadB 4.1.1.15 E Belongs to the group II decarboxylase family
HEGKEINC_00409 2.8e-175 gadC E Psort location CytoplasmicMembrane, score 10.00
HEGKEINC_00411 1.3e-07 L Transposase and inactivated derivatives, TnpA family
HEGKEINC_00412 1.5e-86 tnp L Transposase
HEGKEINC_00413 1.7e-47 tnp L Transposase
HEGKEINC_00414 2.1e-206 rny D Endoribonuclease that initiates mRNA decay
HEGKEINC_00415 2.4e-84 L Transposase
HEGKEINC_00416 2.1e-113 fruR K transcriptional
HEGKEINC_00417 3.8e-165 pfkB 2.7.1.11, 2.7.1.56 H Belongs to the carbohydrate kinase PfkB family. LacC subfamily
HEGKEINC_00418 0.0 fruA 2.7.1.202 G phosphotransferase system
HEGKEINC_00419 2.7e-260 gor 1.8.1.7 C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEGKEINC_00420 1.2e-241 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
HEGKEINC_00422 6.1e-213 iscS2 2.8.1.7 E Cysteine sulfinate desulfinase cysteine desulfurase and related enzymes
HEGKEINC_00423 6.5e-229 thiI 2.8.1.4 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HEGKEINC_00424 4.9e-295 gtf1 2.4.1.52 GT4 M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
HEGKEINC_00425 7.2e-258 gtf2 M A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1
HEGKEINC_00426 6.4e-29 2.3.1.128 K acetyltransferase
HEGKEINC_00427 4.5e-49 rplU J This protein binds to 23S rRNA in the presence of protein L20
HEGKEINC_00428 1.5e-46 rpmA J Belongs to the bacterial ribosomal protein bL27 family
HEGKEINC_00429 1.4e-130 ydaF_2 J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEGKEINC_00430 2.6e-64 WQ51_03320 S cog cog4835
HEGKEINC_00431 6.4e-61 XK27_08360 S EDD domain protein, DegV family
HEGKEINC_00432 5.5e-75 XK27_08360 S EDD domain protein, DegV family
HEGKEINC_00433 5.1e-139 dapB 1.17.1.8 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
HEGKEINC_00434 1.9e-225 cca 2.7.7.19, 2.7.7.72 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HEGKEINC_00435 0.0 yfmR S abc transporter atp-binding protein
HEGKEINC_00436 3.3e-25 U response to pH
HEGKEINC_00437 6e-140 3.6.1.13, 3.6.1.55 F AdP-ribose pyrophosphatase
HEGKEINC_00438 1.1e-164 nadD 2.7.1.22, 2.7.7.1, 2.7.7.18, 3.6.1.55 H adenylyltransferase
HEGKEINC_00439 6.9e-256 gdhA 1.4.1.4 E Belongs to the Glu Leu Phe Val dehydrogenases family
HEGKEINC_00440 1e-69 def_1 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins
HEGKEINC_00441 1.9e-77 K DNA-binding transcription factor activity
HEGKEINC_00442 0.0 lmrA1 V abc transporter atp-binding protein
HEGKEINC_00443 0.0 lmrA2 V abc transporter atp-binding protein
HEGKEINC_00444 5.4e-45 K Acetyltransferase (GNAT) family
HEGKEINC_00445 3.2e-78 sptS 2.7.13.3 T Histidine kinase
HEGKEINC_00446 4.9e-131 pyrH 2.7.4.22 F Catalyzes the reversible phosphorylation of UMP to UDP
HEGKEINC_00447 1.3e-91 frr J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
HEGKEINC_00448 5.3e-161 cvfB S Protein conserved in bacteria
HEGKEINC_00449 7.4e-35 yozE S Belongs to the UPF0346 family
HEGKEINC_00450 1.5e-123 usp 3.5.1.104, 3.5.1.28 CBM50 S pathogenesis
HEGKEINC_00451 2.3e-61 rlpA M LysM domain protein
HEGKEINC_00452 8e-191 phoH T phosphate starvation-inducible protein PhoH
HEGKEINC_00456 0.0 metG 6.1.1.10, 6.1.1.20 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEGKEINC_00457 1.8e-164 K transcriptional regulator (lysR family)
HEGKEINC_00458 1.4e-186 coiA 3.6.4.12 S Competence protein
HEGKEINC_00459 0.0 pepF E oligoendopeptidase F
HEGKEINC_00460 5.4e-127 yrrM 2.1.1.104 S O-Methyltransferase
HEGKEINC_00461 1.3e-167 prsA 3.1.3.16, 5.2.1.8 O peptidyl-prolyl cis-trans isomerase activity
HEGKEINC_00462 0.0 alaS 6.1.1.7 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HEGKEINC_00463 7.9e-24 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
HEGKEINC_00464 1.4e-165 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
HEGKEINC_00465 1.1e-53 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
HEGKEINC_00466 3.9e-120 3.4.17.14, 3.5.1.28 NU amidase activity
HEGKEINC_00467 2.1e-67 cnhA 3.5.1.3 S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
HEGKEINC_00468 3.1e-53 cnhA 3.5.1.3 S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
HEGKEINC_00469 1.8e-223 mtnE 2.6.1.83 E mutations do not affect methionine salvage in vivo however
HEGKEINC_00470 4.2e-189 argC 1.2.1.38 E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HEGKEINC_00471 2.6e-222 argJ 2.3.1.1, 2.3.1.35, 2.7.2.8 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HEGKEINC_00472 3.5e-129 argB 2.7.2.8 E Belongs to the acetylglutamate kinase family. ArgB subfamily
HEGKEINC_00473 5.3e-209 argD 2.6.1.11, 2.6.1.17 E acetylornithine aminotransferase
HEGKEINC_00474 2.5e-129 yxkH G deacetylase
HEGKEINC_00475 4e-237 hom 1.1.1.3, 2.7.2.4 E homoserine dehydrogenase
HEGKEINC_00476 4.2e-150 thrB 2.7.1.39 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
HEGKEINC_00477 1e-151 rarD S Transporter
HEGKEINC_00478 2.6e-16 T peptidase
HEGKEINC_00479 8.9e-14 coiA 3.6.4.12 S Competence protein
HEGKEINC_00480 1.5e-106 S COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HEGKEINC_00481 5.3e-74 2.3.1.128, 5.2.1.8 J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEGKEINC_00482 0.0 valS 6.1.1.9 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
HEGKEINC_00483 1.4e-16 atpE C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HEGKEINC_00484 1.6e-123 atpB C it plays a direct role in the translocation of protons across the membrane
HEGKEINC_00485 2.3e-76 atpF C ATP synthase F(0) sector subunit b
HEGKEINC_00486 3.5e-86 atpH C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HEGKEINC_00487 7.2e-278 atpA 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HEGKEINC_00488 2.5e-158 atpG C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HEGKEINC_00489 2.7e-263 atpD 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HEGKEINC_00490 5.2e-67 atpC C Produces ATP from ADP in the presence of a proton gradient across the membrane
HEGKEINC_00491 2.8e-230 ftsW D Belongs to the SEDS family
HEGKEINC_00492 9.5e-225 tuf J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HEGKEINC_00493 1.4e-136 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
HEGKEINC_00494 2.8e-111 tmk 2.7.4.9 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HEGKEINC_00495 5.4e-161 holB 2.7.7.7 L dna polymerase iii
HEGKEINC_00496 3.1e-134 yaaT S stage 0 sporulation protein
HEGKEINC_00497 9.5e-55 yabA L Involved in initiation control of chromosome replication
HEGKEINC_00498 2.7e-160 rsmI 2.1.1.198 H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HEGKEINC_00499 7.5e-233 amt P Ammonium Transporter
HEGKEINC_00500 1.1e-53 glnB K Belongs to the P(II) protein family
HEGKEINC_00501 4.9e-106 mur1 NU mannosyl-glycoprotein
HEGKEINC_00502 5.8e-149 XK27_04800 S Sucrose-6F-phosphate phosphohydrolase
HEGKEINC_00503 1.2e-92 nptA P COG1283 Na phosphate symporter
HEGKEINC_00504 8e-221 nagA 3.5.1.25 G Belongs to the metallo-dependent hydrolases superfamily. NagA family
HEGKEINC_00505 4.9e-51
HEGKEINC_00506 2.2e-25
HEGKEINC_00507 3.9e-60
HEGKEINC_00508 6.1e-63 S membrane
HEGKEINC_00509 4.8e-176 glyQ 6.1.1.14 J glycyl-tRNA synthetase alpha subunit
HEGKEINC_00510 0.0 glyS 6.1.1.14 J Glycyl-tRNA synthetase beta subunit
HEGKEINC_00511 4.5e-39 ynzC S UPF0291 protein
HEGKEINC_00512 1.8e-254 cycA E permease
HEGKEINC_00513 7e-09 uvrX 2.7.7.7 L impB/mucB/samB family
HEGKEINC_00514 1.7e-70 pts33BCA G pts system
HEGKEINC_00515 2.5e-119 pts33BCA G pts system
HEGKEINC_00516 1.5e-77 2.7.1.199, 2.7.1.211 G PTS glucose transporter subunit IIA
HEGKEINC_00517 3.2e-141 ppiA 5.2.1.8 O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HEGKEINC_00522 1.4e-167 fhuR K transcriptional regulator (lysR family)
HEGKEINC_00523 8.8e-78 lspA 3.4.23.36 MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HEGKEINC_00524 5e-162 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
HEGKEINC_00525 3.7e-88 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HEGKEINC_00526 4.9e-227 pyrP F uracil Permease
HEGKEINC_00527 1e-173 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
HEGKEINC_00528 4.2e-211 carA 6.3.5.5 F carbamoyl-phosphate synthetase glutamine chain
HEGKEINC_00529 0.0 carB 6.3.5.5 F carbamoyl-phosphate synthetase ammonia chain
HEGKEINC_00530 6.6e-131 2.1.1.223 S Putative SAM-dependent methyltransferase
HEGKEINC_00531 9.9e-36 acrA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEGKEINC_00532 1.2e-50 V efflux transmembrane transporter activity
HEGKEINC_00533 3.6e-32 V efflux transmembrane transporter activity
HEGKEINC_00534 7e-27 ytrF V efflux transmembrane transporter activity
HEGKEINC_00535 1.3e-77 rplJ J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HEGKEINC_00536 3e-52 rplL J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
HEGKEINC_00537 2.2e-108 L Transposase
HEGKEINC_00540 3e-92 S MucBP domain
HEGKEINC_00541 1.9e-49 M YSIRK type signal peptide
HEGKEINC_00542 5.4e-14 M the current gene model (or a revised gene model) may contain a
HEGKEINC_00544 0.0 mdlB V abc transporter atp-binding protein
HEGKEINC_00545 0.0 lmrA V abc transporter atp-binding protein
HEGKEINC_00546 1.3e-198 queA 2.4.99.17 J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HEGKEINC_00547 6.8e-122 nagB 3.1.1.31, 3.5.99.6 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
HEGKEINC_00548 1.3e-214 2.7.13.3 T signal transduction protein with a C-terminal ATPase domain
HEGKEINC_00549 2.5e-132 rr02 KT response regulator
HEGKEINC_00550 5.7e-219 2.7.7.73, 2.7.7.80 H Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
HEGKEINC_00551 2.8e-168 V ABC transporter
HEGKEINC_00552 5.4e-122 sagI S ABC-2 type transporter
HEGKEINC_00553 6.9e-197 yceA S Belongs to the UPF0176 family
HEGKEINC_00554 8e-28 XK27_00085 K Transcriptional
HEGKEINC_00555 1.9e-22
HEGKEINC_00556 1.1e-144 deoD_1 2.4.2.3 F Phosphorylase superfamily
HEGKEINC_00557 4.7e-102 S VIT family
HEGKEINC_00558 2.6e-132 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
HEGKEINC_00559 4e-220 hipO 3.5.1.47 E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
HEGKEINC_00560 2.6e-17 ald 1.4.1.1 E alanine dehydrogenase activity
HEGKEINC_00561 1e-46 ald 1.4.1.1 C Belongs to the AlaDH PNT family
HEGKEINC_00562 8e-249 merA 1.16.1.1 C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEGKEINC_00563 4.6e-105 GBS0088 J protein conserved in bacteria
HEGKEINC_00564 2.5e-142 mvk 1.1.1.88, 2.3.3.10, 2.7.1.36 I mevalonate kinase
HEGKEINC_00565 6e-174 mvaD 4.1.1.33 I diphosphomevalonate decarboxylase
HEGKEINC_00566 4.6e-180 mvaK2 2.7.1.36, 2.7.1.43, 2.7.4.2 I GHMP kinases N terminal domain
HEGKEINC_00567 8.9e-192 fni 1.1.1.88, 5.3.3.2 C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
HEGKEINC_00568 1.5e-253 glmU 2.3.1.157, 2.7.7.23 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HEGKEINC_00569 1e-96 nudF 3.6.1.13 L AdP-ribose pyrophosphatase
HEGKEINC_00570 2.5e-21
HEGKEINC_00571 2e-118 mtnN 3.2.2.9 E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HEGKEINC_00573 3.5e-07 U protein secretion
HEGKEINC_00574 2.1e-50 U protein secretion
HEGKEINC_00576 1.1e-192 dgs 2.4.1.208 GT4 M Glycosyltransferase, group 1 family protein
HEGKEINC_00577 1.5e-247 mgs 2.4.1.337 GT4 M Glycosyltransferase, group 1 family protein
HEGKEINC_00578 4.9e-21 XK27_13030
HEGKEINC_00579 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HEGKEINC_00580 4.9e-168 S hydrolases or acyltransferases (alpha beta hydrolase superfamily)
HEGKEINC_00581 2.8e-165 S Protein of unknown function (DUF3114)
HEGKEINC_00582 1.2e-22 S Protein of unknown function (DUF3114)
HEGKEINC_00583 1.5e-118 yqfA K protein, Hemolysin III
HEGKEINC_00584 1e-25 K hmm pf08876
HEGKEINC_00585 2.7e-233 mvaA 1.1.1.34, 1.1.1.88, 2.3.1.9 C Belongs to the HMG-CoA reductase family
HEGKEINC_00586 1.7e-218 mvaS 2.3.3.10 I synthase
HEGKEINC_00587 2.2e-167 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HEGKEINC_00588 3.4e-91 folA 1.5.1.3, 1.5.1.47, 2.1.1.45, 3.5.4.12 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HEGKEINC_00589 9.7e-22
HEGKEINC_00590 2e-225 clpX O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HEGKEINC_00591 3e-110 engB D Necessary for normal cell division and for the maintenance of normal septation
HEGKEINC_00592 1.5e-250 mmuP E amino acid
HEGKEINC_00593 1.2e-177 mmuM 1.5.1.20, 2.1.1.10 H Homocysteine
HEGKEINC_00594 1.4e-29 S Domain of unknown function (DUF1912)
HEGKEINC_00595 4.9e-15 L Helix-hairpin-helix DNA-binding motif class 1
HEGKEINC_00596 7.1e-102 plsY 2.3.1.15, 3.5.1.104 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
HEGKEINC_00597 0.0 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HEGKEINC_00598 0.0 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HEGKEINC_00599 2.4e-200 ilvE 2.6.1.42 E Aminotransferase
HEGKEINC_00600 4.8e-16 S Protein of unknown function (DUF2969)
HEGKEINC_00603 8.4e-205 rpsA 1.17.7.4 J ribosomal protein S1
HEGKEINC_00606 1e-100 S Domain of Unknown Function with PDB structure (DUF3862)
HEGKEINC_00607 6.1e-70 M Pfam SNARE associated Golgi protein
HEGKEINC_00608 1.3e-232 murN 2.3.2.10, 2.3.2.16 V FemAB family
HEGKEINC_00609 9.3e-59 S oxidoreductase
HEGKEINC_00610 9.7e-66 S oxidoreductase
HEGKEINC_00611 4.4e-14 XK27_09445 S Domain of unknown function (DUF1827)
HEGKEINC_00612 3.7e-48 XK27_09445 S Domain of unknown function (DUF1827)
HEGKEINC_00613 1.8e-86 mutT 3.5.4.33, 3.6.1.13, 3.6.1.55 L Belongs to the Nudix hydrolase family
HEGKEINC_00614 0.0 clpE O Belongs to the ClpA ClpB family
HEGKEINC_00615 1.2e-180 argF 2.1.3.3 E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HEGKEINC_00616 1.3e-34 ykuJ S protein conserved in bacteria
HEGKEINC_00617 7.5e-118 WQ51_01820 P Binding-protein-dependent transport system inner membrane component
HEGKEINC_00618 2.2e-131 glnQ 3.6.3.21 E abc transporter atp-binding protein
HEGKEINC_00619 1.1e-78 feoA P FeoA domain protein
HEGKEINC_00620 0.0 feoB P transporter of a GTP-driven Fe(2 ) uptake system
HEGKEINC_00621 1.5e-07
HEGKEINC_00622 2.5e-33 yugF I carboxylic ester hydrolase activity
HEGKEINC_00623 7.5e-23 I Alpha/beta hydrolase family
HEGKEINC_00624 2.7e-157 folD 1.5.1.5, 3.5.4.9 F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HEGKEINC_00625 3.2e-150 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HEGKEINC_00626 0.0 pbp2b 3.4.16.4 M penicillin-binding protein
HEGKEINC_00627 8.4e-105 recR L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HEGKEINC_00628 2.9e-44 licT K transcriptional antiterminator
HEGKEINC_00629 6.8e-53 licT K transcriptional antiterminator
HEGKEINC_00630 5.9e-88 ybeY 2.6.99.2, 3.5.4.5 S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HEGKEINC_00631 8.3e-64 dgkA 2.7.1.107, 2.7.1.66 M Diacylglycerol kinase
HEGKEINC_00632 1.3e-165 era M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HEGKEINC_00633 1.9e-155 fpg 3.2.2.23, 4.2.99.18 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
HEGKEINC_00634 1.3e-105 coaE 2.7.1.24, 3.2.2.23, 4.2.99.18 GH23 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HEGKEINC_00635 2.5e-220 mdtG EGP Major facilitator Superfamily
HEGKEINC_00636 2e-33 secG U Preprotein translocase subunit SecG
HEGKEINC_00637 0.0 rnr J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
HEGKEINC_00638 1.1e-80 smpB O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
HEGKEINC_00639 9.6e-277 ppiB 5.2.1.8 G PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HEGKEINC_00640 1.7e-63 yugI 5.3.1.9 J RNA binding protein, contains ribosomal protein S1 domain
HEGKEINC_00641 4.2e-211 pepQ 3.4.13.9 E Belongs to the peptidase M24B family
HEGKEINC_00642 4.4e-183 ccpA K Catabolite control protein A
HEGKEINC_00643 2.8e-28 yyaQ S YjbR
HEGKEINC_00644 6.6e-101 yyaQ V Protein conserved in bacteria
HEGKEINC_00645 1.3e-207 glxK 2.7.1.165 G Belongs to the glycerate kinase type-1 family
HEGKEINC_00646 1e-78 yueI S Protein of unknown function (DUF1694)
HEGKEINC_00647 9.6e-247 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
HEGKEINC_00648 2e-25 WQ51_00785
HEGKEINC_00649 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
HEGKEINC_00650 6.9e-220 ywbD 2.1.1.191 J Methyltransferase
HEGKEINC_00651 8.6e-122 aroD 1.1.1.25, 4.2.1.10 E Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
HEGKEINC_00652 1.7e-162 aroE 1.1.1.25 E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HEGKEINC_00653 2.9e-201 aroB 2.7.1.71, 4.2.3.4 E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HEGKEINC_00654 4.5e-219 aroC 4.2.3.5 E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HEGKEINC_00655 1.4e-206 tyrA 1.3.1.12, 1.3.1.43 E prephenate dehydrogenase
HEGKEINC_00656 3.2e-53 yheA S Belongs to the UPF0342 family
HEGKEINC_00657 6.7e-173 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
HEGKEINC_00658 2.6e-236 aroA 1.3.1.12, 1.3.1.43, 2.5.1.19 E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
HEGKEINC_00659 1.7e-87 aroK 1.1.1.25, 2.7.1.71, 4.2.1.10, 4.2.3.4 F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HEGKEINC_00660 2.3e-153 pheA 4.2.1.51 E Prephenate dehydratase
HEGKEINC_00661 3.5e-250 msrR K Transcriptional regulator
HEGKEINC_00662 2.2e-149 ydiA P C4-dicarboxylate transporter malic acid transport protein
HEGKEINC_00663 9.1e-203 I acyl-CoA dehydrogenase
HEGKEINC_00664 4.5e-97 mip S hydroperoxide reductase activity
HEGKEINC_00665 5.3e-256 rumA 2.1.1.190 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HEGKEINC_00666 8.9e-20
HEGKEINC_00667 3.2e-46
HEGKEINC_00668 1e-31 K Cro/C1-type HTH DNA-binding domain
HEGKEINC_00669 7.8e-50 dam 2.1.1.72 L D12 class N6 adenine-specific DNA methyltransferase
HEGKEINC_00670 1.5e-25 estA E GDSL-like Lipase/Acylhydrolase
HEGKEINC_00671 8.1e-95
HEGKEINC_00672 0.0 cas9 L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
HEGKEINC_00673 1.1e-172 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HEGKEINC_00674 3.1e-53 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HEGKEINC_00675 1e-185 S CRISPR-associated protein Csn2 subfamily St
HEGKEINC_00676 2.7e-146 ycgQ S TIGR03943 family
HEGKEINC_00677 1.2e-155 XK27_03015 S permease
HEGKEINC_00679 0.0 yhgF K Transcriptional accessory protein
HEGKEINC_00680 9.9e-42 pspC KT PspC domain
HEGKEINC_00681 1e-170 hprK F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HEGKEINC_00682 4e-147 lgt 2.1.1.199 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HEGKEINC_00684 5.5e-69 ytxH S General stress protein
HEGKEINC_00686 2e-177 yegQ O Peptidase U32
HEGKEINC_00687 3.4e-252 yegQ O Peptidase U32
HEGKEINC_00688 8.1e-46 S CHY zinc finger
HEGKEINC_00689 8.4e-88 bioY S biotin synthase
HEGKEINC_00691 1.1e-33 XK27_12190 S protein conserved in bacteria
HEGKEINC_00692 7.8e-236 mntH P H( )-stimulated, divalent metal cation uptake system
HEGKEINC_00693 1.1e-12
HEGKEINC_00694 1.2e-67 nudG 3.6.1.55, 3.6.1.65 L Belongs to the Nudix hydrolase family
HEGKEINC_00695 0.0 L helicase
HEGKEINC_00696 9.9e-288 lysS 6.1.1.6 J Belongs to the class-II aminoacyl-tRNA synthetase family
HEGKEINC_00697 1e-163 M LysM domain
HEGKEINC_00698 7.6e-16
HEGKEINC_00699 2.3e-175 S hydrolase
HEGKEINC_00700 4.3e-115 pgm6 5.4.2.11, 5.4.2.12 G Phosphoglycerate mutase
HEGKEINC_00701 7.9e-82 ybaK S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HEGKEINC_00702 1.6e-145 XK27_00880 3.5.1.28 M Glycosyl hydrolase, family 25
HEGKEINC_00703 2.7e-27 P Hemerythrin HHE cation binding domain protein
HEGKEINC_00704 2.3e-113 1.14.14.5 C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEGKEINC_00705 1.7e-10 MA20_36090 S Protein of unknown function (DUF2974)
HEGKEINC_00706 7.9e-37 MA20_36090 S Protein of unknown function (DUF2974)
HEGKEINC_00707 0.0 hsdR 3.1.21.3 V Type I restriction enzyme R protein N terminus (HSDR_N)
HEGKEINC_00708 7.3e-289 hsdM 2.1.1.72 V N-6 DNA Methylase
HEGKEINC_00709 7.4e-114 hsdS 3.1.21.3 V Type I restriction modification DNA specificity domain
HEGKEINC_00711 7.9e-39
HEGKEINC_00712 6e-172 spd F DNA RNA non-specific endonuclease
HEGKEINC_00713 1.5e-92 lemA S LemA family
HEGKEINC_00714 9.3e-132 htpX O Belongs to the peptidase M48B family
HEGKEINC_00715 2.1e-74 S Psort location CytoplasmicMembrane, score
HEGKEINC_00716 5.3e-55 S Domain of unknown function (DUF4430)
HEGKEINC_00717 0.0 ppc 4.1.1.31 H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HEGKEINC_00718 1.2e-183 holA 2.7.7.7 L DNA polymerase III delta subunit
HEGKEINC_00719 8.5e-113 sodA 1.15.1.1 C radicals which are normally produced within the cells and which are toxic to biological systems
HEGKEINC_00720 1.9e-23 L Transposase
HEGKEINC_00721 2.2e-185 3.5.2.6 V D-alanyl-D-alanine carboxypeptidase
HEGKEINC_00722 4.4e-115 pilD 3.4.23.43 NOU Bacterial Peptidase A24 N-terminal domain
HEGKEINC_00723 3.5e-91 dps P Belongs to the Dps family
HEGKEINC_00724 1.1e-80 perR P Belongs to the Fur family
HEGKEINC_00725 8.4e-28 yqgQ S protein conserved in bacteria
HEGKEINC_00726 2.2e-179 glk 2.7.1.2 G Glucokinase
HEGKEINC_00727 0.0 typA T GTP-binding protein TypA
HEGKEINC_00729 4.6e-252 murD 6.3.2.9 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HEGKEINC_00730 3.9e-201 murG 2.4.1.227 GT28 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HEGKEINC_00731 6.7e-172 divIB D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
HEGKEINC_00732 8e-252 ftsA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
HEGKEINC_00733 5.4e-237 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HEGKEINC_00734 2.3e-122 ylmE S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HEGKEINC_00735 6.8e-96 sepF D cell septum assembly
HEGKEINC_00736 2.6e-34 yggT D integral membrane protein
HEGKEINC_00737 1.2e-143 ylmH T S4 RNA-binding domain
HEGKEINC_00738 1.8e-135 divIVA D Cell division protein DivIVA
HEGKEINC_00739 0.0 ileS 6.1.1.5 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HEGKEINC_00740 8.4e-10
HEGKEINC_00741 3.2e-231 mntH P Mn2 and Fe2 transporters of the NRAMP family
HEGKEINC_00742 2e-45 rpmE2 J 50S ribosomal protein L31
HEGKEINC_00743 9.8e-177 apbE 2.7.1.180 H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
HEGKEINC_00744 1e-184 nrnA 3.1.13.3, 3.1.3.7 S domain protein
HEGKEINC_00745 2.4e-155 gst O Glutathione S-transferase
HEGKEINC_00746 1.6e-188 add 3.5.4.4 F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HEGKEINC_00747 2.4e-112 tdk 2.7.1.21 F thymidine kinase
HEGKEINC_00748 3e-193 prfA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HEGKEINC_00749 1.2e-154 prmB 2.1.1.297, 2.1.1.298 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
HEGKEINC_00750 9.7e-109 ywlC 2.7.7.87, 3.1.3.48 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
HEGKEINC_00751 1.8e-234 glyA 2.1.2.1 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HEGKEINC_00752 1.2e-177 ndpA S 37-kD nucleoid-associated bacterial protein
HEGKEINC_00753 6.6e-105 pvaA M lytic transglycosylase activity
HEGKEINC_00754 0.0 yfiB1 V abc transporter atp-binding protein
HEGKEINC_00755 0.0 XK27_10035 V abc transporter atp-binding protein
HEGKEINC_00756 1.7e-09 S D-Ala-teichoic acid biosynthesis protein
HEGKEINC_00757 1.4e-297 dltA 6.1.1.13 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HEGKEINC_00758 3.9e-237 dltB M Membrane protein involved in D-alanine export
HEGKEINC_00759 1.7e-35 dltC 6.1.1.13 IQ Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HEGKEINC_00760 1.4e-229 dltD M Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HEGKEINC_00761 7.7e-19 L transposase activity
HEGKEINC_00762 0.0 3.6.3.8 P cation transport ATPase
HEGKEINC_00763 0.0 pabB 2.6.1.85, 4.1.3.27, 4.1.3.38 EH component I
HEGKEINC_00765 0.0 metE 2.1.1.14 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HEGKEINC_00766 7.3e-166 metF 1.5.1.20 E reductase
HEGKEINC_00767 0.0 pgm 5.4.2.2, 5.4.2.8 G Phosphoglucomutase
HEGKEINC_00768 1.7e-94 panT S ECF transporter, substrate-specific component
HEGKEINC_00769 4.8e-94 coaBC 4.1.1.36, 6.3.2.5 H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HEGKEINC_00770 1.2e-120 coaB 4.1.1.36, 6.3.2.5 H Phosphopantothenate-cysteine ligase
HEGKEINC_00771 0.0 fhs 6.3.4.3 F Belongs to the formate--tetrahydrofolate ligase family
HEGKEINC_00772 1.4e-90 T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HEGKEINC_00773 2.8e-40 T PhoQ Sensor
HEGKEINC_00774 1.3e-128 T PhoQ Sensor
HEGKEINC_00775 1.3e-29 rpsT J rRNA binding
HEGKEINC_00776 5.5e-172 coaA 2.7.1.33 F Pantothenic acid kinase
HEGKEINC_00777 9.8e-106 rsmC 2.1.1.172 J Methyltransferase small domain protein
HEGKEINC_00778 1.2e-57 pdp 2.4.2.2, 2.4.2.4 F Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate
HEGKEINC_00779 1.3e-97 pdp 2.4.2.2, 2.4.2.4 F Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate
HEGKEINC_00780 1.4e-22 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HEGKEINC_00781 1.4e-38 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HEGKEINC_00782 1.3e-69 cdd 2.4.2.2, 3.5.4.5 F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
HEGKEINC_00783 1.6e-191 tcsA S ABC-type transport system, periplasmic component surface lipoprotein
HEGKEINC_00784 6.4e-282 xylG 3.6.3.17 S ABC transporter, ATP-binding protein
HEGKEINC_00785 4.7e-191 yufP S Belongs to the binding-protein-dependent transport system permease family
HEGKEINC_00786 1e-168 yufQ S Belongs to the binding-protein-dependent transport system permease family
HEGKEINC_00787 2e-120 ycbL 3.1.2.6 S COG0491 Zn-dependent hydrolases, including glyoxylases
HEGKEINC_00788 0.0 dinG 2.7.7.7, 3.6.4.12 L helicase involved in DNA repair and perhaps also replication
HEGKEINC_00789 3.1e-81 ypmB S Protein conserved in bacteria
HEGKEINC_00790 6.5e-218 aspB 2.6.1.1, 2.6.1.14 E Aminotransferase
HEGKEINC_00791 1.7e-262 asnS 6.1.1.22 J Catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
HEGKEINC_00792 1.5e-07
HEGKEINC_00793 3e-13
HEGKEINC_00794 3e-63 tdcF 3.5.99.10 J endoribonuclease L-PSP
HEGKEINC_00795 9.8e-123 queC 6.3.4.20 F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HEGKEINC_00796 2.2e-81 queD 4.1.2.50, 4.2.3.12 H synthase
HEGKEINC_00797 2.5e-135 queE 1.97.1.4, 4.3.99.3 H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
HEGKEINC_00798 6.5e-95 queF 1.7.1.13 S Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily
HEGKEINC_00799 4.2e-18 D nuclear chromosome segregation
HEGKEINC_00800 5.3e-136 yejC S cyclic nucleotide-binding protein
HEGKEINC_00801 1.2e-163 rapZ S Displays ATPase and GTPase activities
HEGKEINC_00802 3.6e-182 ybhK S Required for morphogenesis under gluconeogenic growth conditions
HEGKEINC_00803 8.7e-162 whiA K May be required for sporulation
HEGKEINC_00804 8.2e-120 pepD E Dipeptidase
HEGKEINC_00805 5.8e-41 pepD E dipeptidase activity
HEGKEINC_00806 5.4e-32 cspD K Cold shock protein domain
HEGKEINC_00807 3.6e-42 K Cold-Shock Protein
HEGKEINC_00808 0.0 copB 3.6.3.4 P haloacid dehalogenase-like hydrolase
HEGKEINC_00809 2.9e-190 3.1.21.3 L Subunit R is required for both nuclease and ATPase activities, but not for modification
HEGKEINC_00810 2.3e-170 mccA 2.5.1.134, 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
HEGKEINC_00811 9.1e-220 metC 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
HEGKEINC_00812 1.5e-59 cysE 2.3.1.30 E serine acetyltransferase
HEGKEINC_00813 1.5e-55 hsdS 2.1.1.72, 3.1.21.3 V type I restriction modification DNA specificity domain
HEGKEINC_00814 3.7e-111 hsdM 2.1.1.72 V type I restriction-modification system
HEGKEINC_00815 1.2e-155 glcU U Glucose uptake
HEGKEINC_00816 1.1e-08 mycA 4.2.1.53 S Myosin-crossreactive antigen
HEGKEINC_00817 3.4e-79 hsdM 2.1.1.72 V HsdM N-terminal domain
HEGKEINC_00818 1.3e-88 XK27_10720 D peptidase activity
HEGKEINC_00819 8.9e-292 adcA P Belongs to the bacterial solute-binding protein 9 family
HEGKEINC_00820 1.7e-08
HEGKEINC_00822 2.7e-172 yeiH S Membrane
HEGKEINC_00823 2.9e-115 mur1 NU muramidase
HEGKEINC_00824 1.9e-83 L transposition
HEGKEINC_00825 2.6e-166 cpsY K Transcriptional regulator
HEGKEINC_00826 0.0 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
HEGKEINC_00827 2.5e-58 phnA P Alkylphosphonate utilization operon protein PhnA
HEGKEINC_00828 4e-105 artQ P ABC transporter (Permease
HEGKEINC_00829 1.5e-112 glnQ 3.6.3.21 E abc transporter atp-binding protein
HEGKEINC_00830 1.2e-157 aatB ET ABC transporter substrate-binding protein
HEGKEINC_00831 3.5e-40 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HEGKEINC_00832 4.2e-139 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HEGKEINC_00833 1.7e-57 adhP 1.1.1.1 C alcohol dehydrogenase
HEGKEINC_00834 1.3e-106 adhP 1.1.1.1 C alcohol dehydrogenase
HEGKEINC_00835 3.6e-49 sthIM 2.1.1.72 L Adenine specific DNA methylase Mod
HEGKEINC_00836 1.3e-303 guaA 2.3.1.128, 6.3.5.2 F Catalyzes the synthesis of GMP from XMP
HEGKEINC_00837 2.9e-125 gntR1 K transcriptional
HEGKEINC_00838 1.1e-53 ylxM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HEGKEINC_00839 3.2e-265 ffh 3.6.5.4 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HEGKEINC_00840 4.1e-87 niaX
HEGKEINC_00841 8.6e-90 niaR S small molecule binding protein (contains 3H domain)
HEGKEINC_00842 1.8e-127 K DNA-binding helix-turn-helix protein
HEGKEINC_00843 1.1e-158 ylqF S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HEGKEINC_00844 1.4e-136 rnhB 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HEGKEINC_00845 8.2e-168 GK ROK family
HEGKEINC_00846 8.3e-159 dprA LU DNA protecting protein DprA
HEGKEINC_00847 0.0 topA 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HEGKEINC_00848 6.7e-153 S TraX protein
HEGKEINC_00849 2.2e-122 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HEGKEINC_00850 1.8e-251 T PhoQ Sensor
HEGKEINC_00851 6.6e-259 trmFO 2.1.1.74 J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HEGKEINC_00852 1.1e-152 XK27_05470 E Methionine synthase
HEGKEINC_00853 1.7e-75 ndk 2.7.4.6 F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
HEGKEINC_00854 2.7e-48 pspE P Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HEGKEINC_00855 1.8e-51 IQ Acetoin reductase
HEGKEINC_00856 3.9e-19 IQ Acetoin reductase
HEGKEINC_00857 0.0 lepA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
HEGKEINC_00858 2e-155 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
HEGKEINC_00861 1.3e-212 pqqE C radical SAM domain protein
HEGKEINC_00862 3.9e-136 speB 3.5.3.11 E hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
HEGKEINC_00863 6.6e-61 EGP Major facilitator Superfamily
HEGKEINC_00864 0.0 alsS 2.2.1.6 EH Belongs to the TPP enzyme family
HEGKEINC_00865 3e-133 budA 4.1.1.5 H Belongs to the alpha-acetolactate decarboxylase family
HEGKEINC_00866 4.3e-13
HEGKEINC_00867 6.4e-104 V ABC transporter (Permease
HEGKEINC_00868 2.8e-115 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
HEGKEINC_00869 1.6e-10
HEGKEINC_00870 1.2e-97 K Transcriptional regulator, TetR family
HEGKEINC_00871 1.8e-159 czcD P cation diffusion facilitator family transporter
HEGKEINC_00872 2.7e-210 hemH 4.99.1.1, 4.99.1.9 H Catalyzes the ferrous insertion into protoporphyrin IX
HEGKEINC_00873 6.2e-196 adhB 1.1.1.1, 1.1.1.14 E Dehydrogenase
HEGKEINC_00874 6e-08 S Hydrolases of the alpha beta superfamily
HEGKEINC_00875 7.9e-17 S Alpha/beta hydrolase of unknown function (DUF915)
HEGKEINC_00876 4.5e-79 S Alpha/beta hydrolase of unknown function (DUF915)
HEGKEINC_00879 1.2e-143 2.4.2.3 F Phosphorylase superfamily
HEGKEINC_00880 4.1e-118 gph 3.1.3.18 S HAD hydrolase, family IA, variant 1
HEGKEINC_00881 1.8e-24 yclQ P ABC-type enterochelin transport system, periplasmic component
HEGKEINC_00882 3.6e-18 yclQ P ABC-type enterochelin transport system, periplasmic component
HEGKEINC_00884 9.2e-311 FbpA K RNA-binding protein homologous to eukaryotic snRNP
HEGKEINC_00885 3.7e-190
HEGKEINC_00886 3.1e-89 FNV0100 F Belongs to the Nudix hydrolase family
HEGKEINC_00887 3.5e-28 3.4.13.21 I Protein conserved in bacteria
HEGKEINC_00889 5.7e-118 S TraX protein
HEGKEINC_00890 1.3e-96 thiJ 2.7.11.1, 3.5.1.124 S DJ-1 family
HEGKEINC_00891 1.3e-148 pyrK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )
HEGKEINC_00892 7.2e-175 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
HEGKEINC_00893 1.3e-187 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HEGKEINC_00894 1.1e-53 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HEGKEINC_00895 6.8e-133 cas6 S CRISPR-associated endoribonuclease Cas6
HEGKEINC_00896 0.0 csm1 S CRISPR-associated protein Csm1 family
HEGKEINC_00897 2.5e-62 csm2 L Csm2 Type III-A
HEGKEINC_00898 1.6e-117 csm3 L RAMP superfamily
HEGKEINC_00899 2.3e-167 csm4 L CRISPR-associated RAMP protein, Csm4 family
HEGKEINC_00900 2e-205 csm5 L CRISPR-associated RAMP protein, Csm5 family
HEGKEINC_00902 9.5e-32 csm6 S Psort location Cytoplasmic, score
HEGKEINC_00903 2.4e-127 pyrF 4.1.1.23 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
HEGKEINC_00904 7.5e-112 pyrE 2.4.2.10, 4.1.1.23 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HEGKEINC_00905 1.6e-266 dtpT E transporter
HEGKEINC_00906 1.4e-62 yecS P ABC transporter (Permease
HEGKEINC_00907 2.3e-20 yecS P amino acid transport
HEGKEINC_00909 0.0 sasH 3.1.3.5, 3.6.1.45 F Belongs to the 5'-nucleotidase family
HEGKEINC_00910 1.6e-247 mnmE S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HEGKEINC_00911 3.1e-240 agcS E (Alanine) symporter
HEGKEINC_00912 0.0 pcrA 3.6.4.12 L ATP-dependent DNA helicase
HEGKEINC_00913 4.6e-241 metY 2.5.1.49 E o-acetylhomoserine
HEGKEINC_00914 2.2e-134 S haloacid dehalogenase-like hydrolase
HEGKEINC_00915 1.3e-87 tpx 1.11.1.15 O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HEGKEINC_00916 1.1e-110 hsdS2 2.1.1.72 V Type I restriction modification DNA specificity domain
HEGKEINC_00917 6.3e-32 M1-755 P Hemerythrin HHE cation binding domain protein
HEGKEINC_00918 6.1e-84 XK27_04775 S hemerythrin HHE cation binding domain
HEGKEINC_00919 2.6e-49 XK27_04775 S hemerythrin HHE cation binding domain
HEGKEINC_00920 3.2e-150 truB 5.4.99.25 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HEGKEINC_00921 5.3e-175 ribF 2.7.1.26, 2.7.7.2 H Belongs to the ribF family
HEGKEINC_00922 1.4e-71 spxA 1.20.4.1 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
HEGKEINC_00923 1.9e-43 yktA S Belongs to the UPF0223 family
HEGKEINC_00924 5e-142 suhB 3.1.3.25 G Belongs to the inositol monophosphatase superfamily
HEGKEINC_00925 3e-256 rsmF 2.1.1.176, 2.1.1.178 J NOL1 NOP2 sun family protein
HEGKEINC_00926 3.3e-158 pstS P phosphate
HEGKEINC_00927 2.5e-156 pstC P probably responsible for the translocation of the substrate across the membrane
HEGKEINC_00928 1.2e-155 pstA P phosphate transport system permease
HEGKEINC_00929 1e-150 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
HEGKEINC_00930 2.3e-139 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
HEGKEINC_00931 1.9e-113 phoU P Plays a role in the regulation of phosphate uptake
HEGKEINC_00932 0.0 pepN 3.4.11.2 E aminopeptidase
HEGKEINC_00933 7e-195 xerS D Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division
HEGKEINC_00934 8.5e-187 lplA 6.3.1.20 H Lipoate-protein ligase
HEGKEINC_00935 3.4e-17
HEGKEINC_00937 0.0 glgP 2.4.1.1 GT35 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
HEGKEINC_00938 1.4e-302 malQ 2.4.1.25 GH77 G 4-alpha-glucanotransferase
HEGKEINC_00939 2.3e-23 L Transposase
HEGKEINC_00940 4.6e-25 tatA U protein secretion
HEGKEINC_00941 5.8e-121 tatC U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HEGKEINC_00942 7.4e-300 ywbL P COG0672 High-affinity Fe2 Pb2 permease
HEGKEINC_00943 3.3e-233 ycdB P peroxidase
HEGKEINC_00944 7.1e-153 ycdO P periplasmic lipoprotein involved in iron transport
HEGKEINC_00945 3e-34 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
HEGKEINC_00946 3.7e-85 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
HEGKEINC_00947 1.7e-60 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
HEGKEINC_00948 1.5e-65 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
HEGKEINC_00949 1.1e-134 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
HEGKEINC_00950 1.9e-186 3.5.1.28 M GBS Bsp-like repeat
HEGKEINC_00951 1.9e-65 3.2.1.17 M lysozyme activity
HEGKEINC_00952 3.8e-11 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
HEGKEINC_00953 0.0 lpdA 1.8.1.4 C Dehydrogenase
HEGKEINC_00954 1.8e-198 acoC 2.3.1.12 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
HEGKEINC_00955 3.7e-182 acoB 1.2.4.1, 1.2.4.4 C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
HEGKEINC_00956 1.7e-184 acoA 1.2.4.1, 1.2.4.4 C Dehydrogenase E1 component
HEGKEINC_00957 0.0 S the current gene model (or a revised gene model) may contain a frame shift
HEGKEINC_00958 3.5e-129 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
HEGKEINC_00959 2.7e-97 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
HEGKEINC_00960 7.7e-128 ung 3.2.2.27 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HEGKEINC_00961 1.6e-216 yeaB K Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HEGKEINC_00962 5.9e-22 dacA1 3.4.16.4 M Belongs to the peptidase S11 family
HEGKEINC_00963 3.9e-24 3.4.16.4 M Belongs to the peptidase S11 family
HEGKEINC_00964 2.3e-26 3.4.16.4 M Belongs to the peptidase S11 family
HEGKEINC_00965 4.3e-83 3.4.16.4 M Belongs to the peptidase S11 family
HEGKEINC_00966 1.2e-157 rssA S Phospholipase, patatin family
HEGKEINC_00967 1.8e-69 estA E GDSL-like protein
HEGKEINC_00968 3.4e-29 estA E Lysophospholipase L1 and related esterases
HEGKEINC_00969 5.9e-291 S unusual protein kinase
HEGKEINC_00970 4.9e-39 S granule-associated protein
HEGKEINC_00971 2.1e-35 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
HEGKEINC_00972 7e-116 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
HEGKEINC_00973 2e-18 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
HEGKEINC_00974 2.5e-198 S hmm pf01594
HEGKEINC_00975 5.1e-102 G Belongs to the phosphoglycerate mutase family
HEGKEINC_00976 1.5e-33 G Belongs to the phosphoglycerate mutase family
HEGKEINC_00977 9.2e-93 V VanZ like family
HEGKEINC_00978 3.2e-51 tnp L DDE domain
HEGKEINC_00979 1.8e-24 S Bacterial transferase hexapeptide (six repeats)
HEGKEINC_00980 1.7e-156 L EVIDENCE EXPERIMENTAL PMID 1328163 BIO14.04 Transposon related functions. BELONGS TO THE IS3 IS150 IS904 FAMILY OF TRANSPOSASE. There are 7 such elements in the chromosome
HEGKEINC_00981 3.7e-58 L Helix-turn-helix domain
HEGKEINC_00982 1.3e-134 L Transposase
HEGKEINC_00983 1.4e-192 wbbI M transferase activity, transferring glycosyl groups
HEGKEINC_00984 4.1e-214 glf 5.4.99.9 M UDP-galactopyranose mutase
HEGKEINC_00985 1.6e-242 epsU S Polysaccharide biosynthesis protein
HEGKEINC_00986 1.4e-100 cps3F
HEGKEINC_00987 3.4e-135 M Glycosyltransferase like family 2
HEGKEINC_00988 3.4e-119 M Glycosyltransferase, group 2 family protein
HEGKEINC_00990 3.4e-135 M transferase activity, transferring glycosyl groups
HEGKEINC_00991 3.4e-211 wcoF M Glycosyltransferase, group 1 family protein
HEGKEINC_00992 5.3e-220 rgpAc GT4 M group 1 family protein
HEGKEINC_00993 5.2e-251 cpsE M Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
HEGKEINC_00994 1e-115 cpsD D COG0489 ATPases involved in chromosome partitioning
HEGKEINC_00995 2.2e-104 cps4C M biosynthesis protein
HEGKEINC_00996 8.6e-136 cpsB 3.1.3.48 GM Capsular polysaccharide biosynthesis protein
HEGKEINC_00997 1e-252 cps4A K Cell envelope-like function transcriptional attenuator common domain protein
HEGKEINC_00998 5.8e-129 deoD 2.4.2.1, 2.4.2.28 F purine nucleoside phosphorylase
HEGKEINC_00999 2.4e-38 yfeJ 6.3.5.2 F glutamine amidotransferase
HEGKEINC_01000 1.2e-65 yfeJ 6.3.5.2 F glutamine amidotransferase
HEGKEINC_01001 2e-63 clcA_2 P chloride
HEGKEINC_01002 5.8e-149 punA 2.4.2.1 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HEGKEINC_01003 1.3e-41 S Protein of unknown function (DUF1697)
HEGKEINC_01004 3.8e-237 deoB 5.4.2.7 G Phosphotransfer between the C1 and C5 carbon atoms of pentose
HEGKEINC_01005 1.7e-122 rpiA 2.7.1.12, 2.7.1.15, 5.3.1.6 G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HEGKEINC_01007 4e-21 V Glucan-binding protein C
HEGKEINC_01008 1e-110 ung2 3.2.2.27 L Uracil-DNA glycosylase
HEGKEINC_01009 2.9e-273 pepV 3.5.1.18 E Dipeptidase
HEGKEINC_01010 6.4e-27 dmpI 5.3.2.6 G Belongs to the 4-oxalocrotonate tautomerase family
HEGKEINC_01011 6.5e-84 XK27_03610 K Gnat family
HEGKEINC_01012 2.2e-84 L Transposase
HEGKEINC_01013 1.5e-56 rplT J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HEGKEINC_01014 8.1e-28 rpmI J Belongs to the bacterial ribosomal protein bL35 family
HEGKEINC_01015 3.5e-86 infC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HEGKEINC_01016 2.5e-121 cmk 1.17.7.4, 2.5.1.19, 2.7.1.26, 2.7.4.25, 2.7.7.2, 6.3.2.1 F Belongs to the cytidylate kinase family. Type 1 subfamily
HEGKEINC_01017 2.8e-18 M LysM domain
HEGKEINC_01018 2.9e-90 ebsA S Family of unknown function (DUF5322)
HEGKEINC_01019 4.2e-228 pepT 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
HEGKEINC_01020 3e-96 lepB 3.4.21.89 U Belongs to the peptidase S26 family
HEGKEINC_01021 2.4e-223 G COG0457 FOG TPR repeat
HEGKEINC_01022 8.1e-176 yubA S permease
HEGKEINC_01023 3.5e-93 mutX 3.6.1.55 F NTP pyrophosphohydrolases including oxidative damage repair enzymes
HEGKEINC_01024 3.6e-163 ftsX D Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation
HEGKEINC_01025 2.5e-124 ftsE D cell division ATP-binding protein FtsE
HEGKEINC_01026 7.4e-183 prfB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HEGKEINC_01027 2e-206 queG 1.17.99.6 C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HEGKEINC_01028 1.7e-164 yjjH S Calcineurin-like phosphoesterase
HEGKEINC_01029 3.3e-135 nfrA 1.5.1.38, 1.5.1.39 C nitroreductase
HEGKEINC_01030 0.0 pacL 3.6.3.8 P cation transport ATPase
HEGKEINC_01031 2.6e-67 ywiB S Domain of unknown function (DUF1934)
HEGKEINC_01032 6.3e-51 XK27_00115 2.3.1.128 K acetyltransferase
HEGKEINC_01033 9.2e-147 yidA S hydrolases of the HAD superfamily
HEGKEINC_01034 9e-231 murM 2.3.2.10, 2.3.2.16 V protein involved in methicillin resistance
HEGKEINC_01035 2.1e-154 vicX 3.1.26.11 S Metal-dependent hydrolases of the beta-lactamase superfamily I
HEGKEINC_01036 1.5e-247 vicK 2.7.13.3 T Histidine kinase
HEGKEINC_01037 9.9e-129 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HEGKEINC_01038 2.1e-140 glnQ 3.6.3.21 E abc transporter atp-binding protein
HEGKEINC_01039 3.1e-150 peb1A ET ABC-type amino acid transport signal transduction systems, periplasmic component domain
HEGKEINC_01040 7.7e-118 gltJ P ABC transporter (Permease
HEGKEINC_01041 4.2e-110 tcyB_2 P ABC transporter (permease)
HEGKEINC_01042 2.4e-124 endA F DNA RNA non-specific endonuclease
HEGKEINC_01043 1.2e-25 epuA S DNA-directed RNA polymerase subunit beta
HEGKEINC_01044 2.5e-231 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HEGKEINC_01046 2.7e-196 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
HEGKEINC_01047 1.6e-34 5.1.3.2 GM Psort location CytoplasmicMembrane, score
HEGKEINC_01048 2.1e-203 metK 2.5.1.6 H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HEGKEINC_01049 4.2e-175 birA 6.3.4.15 HK Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
HEGKEINC_01051 3.2e-295 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HEGKEINC_01052 1.6e-88 ytsP 1.8.4.14 T GAF domain-containing protein
HEGKEINC_01053 1.9e-164 miaA 2.5.1.75 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HEGKEINC_01054 2.1e-19 WQ51_02665 S Protein of unknown function (DUF3042)
HEGKEINC_01057 8.5e-57 rplS J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
HEGKEINC_01058 3.2e-220 XK27_05110 P chloride
HEGKEINC_01059 8.7e-41 pheA 1.3.1.12, 2.3.1.79, 4.2.1.51, 5.4.99.5 E Chorismate mutase
HEGKEINC_01060 1.3e-282 clcA P Chloride transporter, ClC family
HEGKEINC_01061 2.3e-75 fld C Flavodoxin
HEGKEINC_01063 4.7e-126 XK27_08875 O Zinc-dependent metalloprotease
HEGKEINC_01064 3.9e-150 estA CE1 S Putative esterase
HEGKEINC_01065 3.5e-310 rnjB S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HEGKEINC_01066 3.4e-135 XK27_08845 S abc transporter atp-binding protein
HEGKEINC_01067 4e-148 XK27_08840 S Belongs to the binding-protein-dependent transport system permease family
HEGKEINC_01068 3.3e-178 XK27_08835 S ABC transporter substrate binding protein
HEGKEINC_01069 3.2e-17 S Domain of unknown function (DUF4649)
HEGKEINC_01071 4.8e-12 Q the current gene model (or a revised gene model) may contain a frame shift
HEGKEINC_01072 9.4e-14 Q the current gene model (or a revised gene model) may contain a frame shift
HEGKEINC_01073 8.3e-10 Q the current gene model (or a revised gene model) may contain a frame shift
HEGKEINC_01074 9.3e-278 pyk 2.7.1.40, 2.7.7.4 G Belongs to the pyruvate kinase family
HEGKEINC_01075 1.2e-188 pfkA 2.7.1.11 F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
HEGKEINC_01076 0.0 dnaE 2.7.7.7 L DNA polymerase
HEGKEINC_01077 1.4e-152 sua5 2.7.7.87 J Belongs to the SUA5 family
HEGKEINC_01078 3.1e-112 leuD 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HEGKEINC_01079 6.8e-275 leuC 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HEGKEINC_01080 2.5e-43 ysdA L Membrane
HEGKEINC_01081 6.6e-190 leuB 1.1.1.85 CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
HEGKEINC_01082 3.4e-291 leuA 2.3.3.13 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEGKEINC_01083 4.6e-131 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HEGKEINC_01084 3.6e-179 pyrD 1.3.1.14, 1.3.98.1 F Catalyzes the conversion of dihydroorotate to orotate
HEGKEINC_01086 2.8e-39 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
HEGKEINC_01087 1.7e-83 ypmS S Protein conserved in bacteria
HEGKEINC_01088 6e-144 ypmR E lipolytic protein G-D-S-L family
HEGKEINC_01089 1e-148 DegV S DegV family
HEGKEINC_01090 2.2e-304 recN L May be involved in recombinational repair of damaged DNA
HEGKEINC_01091 3.7e-73 argR K Regulates arginine biosynthesis genes
HEGKEINC_01092 5e-159 rrmJ 2.1.1.226, 2.1.1.227 J Ribosomal RNA large subunit methyltransferase J
HEGKEINC_01093 3e-159 ispA 2.5.1.1, 2.5.1.10, 2.5.1.29, 2.5.1.90 H Belongs to the FPP GGPP synthase family
HEGKEINC_01094 3.5e-29 xseB 3.1.11.6 L exodeoxyribonuclease VII activity
HEGKEINC_01095 1.2e-247 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HEGKEINC_01098 3.4e-120 nth 4.2.99.18 L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HEGKEINC_01099 2.9e-125 dnaD
HEGKEINC_01100 4.6e-182 metA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HEGKEINC_01101 2e-94 apt 2.4.2.22, 2.4.2.7 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HEGKEINC_01102 0.0 recJ L Single-strand DNA-specific exonuclease, C terminal domain
HEGKEINC_01103 6.7e-139 XK27_05435 1.1.1.100 S Belongs to the short-chain dehydrogenases reductases (SDR) family
HEGKEINC_01104 2e-174 rnz 3.1.26.11 S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
HEGKEINC_01105 1e-116 galT 2.7.7.12 G UDPglucose--hexose-1-phosphate uridylyltransferase
HEGKEINC_01106 7.8e-222 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HEGKEINC_01107 3.6e-239 rodA D Belongs to the SEDS family
HEGKEINC_01108 1.8e-50 hisE 3.5.4.19, 3.6.1.31, 5.3.1.16 E Phosphoribosyl-ATP
HEGKEINC_01109 8e-60 hisI 3.5.4.19, 3.5.4.25, 3.6.1.31, 5.3.1.16 E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HEGKEINC_01110 2e-135 hisF 3.5.4.19, 3.6.1.31 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
HEGKEINC_01111 1.9e-127 hisA 5.3.1.16 E 1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HEGKEINC_01112 9.8e-109 hisH E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HEGKEINC_01113 1.5e-106 hisB 1.1.1.23, 2.6.1.9, 3.1.3.15, 4.2.1.19 E imidazoleglycerol-phosphate dehydratase
HEGKEINC_01114 7.8e-233 hisD 1.1.1.23, 1.1.1.308 E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HEGKEINC_01115 4e-116 hisG 2.4.2.17 E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
HEGKEINC_01116 5.7e-183 hisZ 2.4.2.17, 6.1.1.21 E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HEGKEINC_01117 4.1e-195 hisC 2.6.1.9 E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEGKEINC_01119 1.9e-86 L Integrase core domain protein
HEGKEINC_01120 1.8e-21 L Transposase
HEGKEINC_01121 5.2e-36 L transposase activity
HEGKEINC_01122 1.3e-22 XK27_08085
HEGKEINC_01123 1.5e-70 XK27_08080 3.1.1.53 G Exopolysaccharide biosynthesis protein
HEGKEINC_01124 2.3e-09 XK27_08080 3.1.1.53 G Exopolysaccharide biosynthesis protein
HEGKEINC_01125 2e-140 hisK 3.1.3.15 E Histidinol phosphatase and related hydrolases of the PHP family
HEGKEINC_01126 1e-119 ylfI S tigr01906
HEGKEINC_01127 5.9e-143 nagD 2.7.1.25, 3.1.3.41 G Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
HEGKEINC_01128 1.5e-143 fat 3.1.2.21 I Acyl-ACP thioesterase
HEGKEINC_01129 4.1e-217 hemN H Involved in the biosynthesis of porphyrin-containing compound
HEGKEINC_01132 1.9e-205 rfbB 4.2.1.46 M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
HEGKEINC_01133 8.3e-113 rmlC 1.1.1.133, 5.1.3.13 M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
HEGKEINC_01134 1.9e-161 rfbA 2.7.7.24 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HEGKEINC_01135 6.3e-207 yurR 1.4.5.1 E oxidoreductase
HEGKEINC_01136 5.7e-102 zupT P Mediates zinc uptake. May also transport other divalent cations
HEGKEINC_01137 9.6e-149 yqfO 3.5.4.16 S Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HEGKEINC_01138 2.7e-123 trmK 2.1.1.217 S SAM-dependent methyltransferase
HEGKEINC_01139 1.7e-70 gtrA S GtrA-like protein
HEGKEINC_01140 1.5e-250 glmM 5.4.2.10 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEGKEINC_01141 6e-169 ybbR S Protein conserved in bacteria
HEGKEINC_01142 2.8e-123 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HEGKEINC_01143 7.5e-255 murD 3.4.21.10, 6.3.2.13, 6.3.2.9 M Mur ligase, middle domain protein
HEGKEINC_01144 8.7e-150 cobQ S glutamine amidotransferase
HEGKEINC_01145 0.0 mprF 2.3.2.3 J Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HEGKEINC_01146 2.2e-131 pip 1.11.1.10 S Alpha beta hydrolase
HEGKEINC_01147 0.0 uup S abc transporter atp-binding protein
HEGKEINC_01148 4.2e-86 udk 2.7.1.48 F Cytidine monophosphokinase
HEGKEINC_01149 4.1e-18 udk 2.7.1.48 F Cytidine monophosphokinase
HEGKEINC_01150 2.1e-178 yfmL 3.6.4.13 L DEAD DEAH box helicase
HEGKEINC_01151 2.1e-28 6.3.2.2, 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
HEGKEINC_01152 8.6e-265 gapN 1.2.1.9 C Belongs to the aldehyde dehydrogenase family
HEGKEINC_01153 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEGKEINC_01154 7.9e-39 ptsH G phosphocarrier protein Hpr
HEGKEINC_01155 7.4e-222 icd 1.1.1.42 C Isocitrate dehydrogenase
HEGKEINC_01156 1.5e-211 citZ 2.3.3.1 C Belongs to the citrate synthase family
HEGKEINC_01157 0.0 acnA 4.2.1.3 C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HEGKEINC_01158 2.2e-34 nrdH O Glutaredoxin
HEGKEINC_01159 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HEGKEINC_01160 1.7e-184 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HEGKEINC_01162 4.2e-71 L Transposase (IS116 IS110 IS902 family)
HEGKEINC_01163 3.3e-26 L Transposase (IS116 IS110 IS902 family)
HEGKEINC_01164 1.8e-165 ypuA S secreted protein
HEGKEINC_01165 1.4e-71 yaeR E COG0346 Lactoylglutathione lyase and related lyases
HEGKEINC_01166 1.7e-134 srtA 3.4.22.70 M Sortase (surface protein transpeptidase)
HEGKEINC_01167 0.0 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HEGKEINC_01168 2.6e-180 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
HEGKEINC_01169 2.6e-258 noxE P NADH oxidase
HEGKEINC_01170 2.5e-294 yfmM S abc transporter atp-binding protein
HEGKEINC_01171 5.6e-84 XK27_01265 S ECF-type riboflavin transporter, S component
HEGKEINC_01172 9.3e-87 pdxK 2.7.1.35 H Belongs to the pyridoxine kinase family
HEGKEINC_01173 5.5e-42 pdxK 2.7.1.35 H Belongs to the pyridoxine kinase family
HEGKEINC_01174 2e-86 S ECF-type riboflavin transporter, S component
HEGKEINC_01176 7.7e-241 XK27_08130 K Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
HEGKEINC_01177 2e-55 nrdD_1 1.1.98.6, 1.17.4.1 F Ribonucleoside-triphosphate reductase
HEGKEINC_01179 0.0 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HEGKEINC_01180 9.9e-94 paiA 2.3.1.57 K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HEGKEINC_01181 1.1e-197 pheS 6.1.1.20 J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HEGKEINC_01182 0.0 smc D Required for chromosome condensation and partitioning
HEGKEINC_01183 8.4e-125 rnc 3.1.26.3 J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
HEGKEINC_01184 6.6e-173 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEGKEINC_01185 7.3e-200 asd 1.2.1.11 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HEGKEINC_01186 4.7e-87 alkD L Dna alkylation repair
HEGKEINC_01187 2.8e-93 pat 2.3.1.183 M acetyltransferase
HEGKEINC_01188 3e-13
HEGKEINC_01189 6.9e-278 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEGKEINC_01190 0.0 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
HEGKEINC_01191 5.1e-130 yjjG 3.1.3.102, 3.1.3.104, 3.1.3.5, 3.8.1.2 E hydrolase
HEGKEINC_01192 3.8e-122 sdaAB 4.3.1.17 E L-serine dehydratase
HEGKEINC_01193 2.8e-149 sdaAA 4.3.1.17 E L-serine dehydratase
HEGKEINC_01194 7.4e-26
HEGKEINC_01195 9.3e-144 S ABC-2 family transporter protein
HEGKEINC_01196 3.5e-33 S transport system, permease component
HEGKEINC_01197 9.5e-98 S transport system, permease component
HEGKEINC_01198 4.4e-101 desR K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HEGKEINC_01199 1.5e-192 desK 2.7.13.3 T Histidine kinase
HEGKEINC_01200 1.5e-132 yvfS V ABC-2 type transporter
HEGKEINC_01201 5.7e-158 XK27_09825 V abc transporter atp-binding protein
HEGKEINC_01205 3.3e-212 EGP Major facilitator Superfamily
HEGKEINC_01206 0.0 2.7.7.73, 2.7.7.80 E metalloendopeptidase activity
HEGKEINC_01207 1.2e-152 mutR K Transcriptional activator, Rgg GadR MutR family
HEGKEINC_01208 4.6e-42 3.6.1.55 F NUDIX domain
HEGKEINC_01210 3.7e-122 S An automated process has identified a potential problem with this gene model
HEGKEINC_01211 6.1e-26 XK27_09825 V 'abc transporter, ATP-binding protein
HEGKEINC_01212 1.4e-15 liaI KT membrane
HEGKEINC_01213 2.6e-30 liaI KT membrane
HEGKEINC_01214 6e-99 XK27_05000 S Fe-S-cluster oxidoreductase
HEGKEINC_01215 0.0 V ABC transporter (permease)
HEGKEINC_01216 1.9e-133 macB2 V ABC transporter, ATP-binding protein
HEGKEINC_01217 6.2e-166 T Histidine kinase
HEGKEINC_01218 4.6e-123 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HEGKEINC_01219 2e-77 xpt 2.4.2.22, 2.4.2.7 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
HEGKEINC_01220 3.3e-69 pbuX F xanthine permease
HEGKEINC_01221 9.2e-119 pbuX F xanthine permease
HEGKEINC_01222 1.5e-247 norM V Multidrug efflux pump
HEGKEINC_01223 4.3e-188 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HEGKEINC_01224 3.5e-85 yxeM ET Belongs to the bacterial solute-binding protein 3 family
HEGKEINC_01225 2.9e-198 pcaB 4.3.2.2 F Adenylosuccinate lyase
HEGKEINC_01226 7.3e-93 yxeO 3.6.3.21 E abc transporter atp-binding protein
HEGKEINC_01227 4.1e-63 yxeN U ABC transporter, permease protein
HEGKEINC_01228 5.4e-58 yxeL K Acetyltransferase (GNAT) domain
HEGKEINC_01229 3e-115 yxeQ S MmgE/PrpD family
HEGKEINC_01230 6e-147 ykrV3 2.6.1.83 E mutations do not affect methionine salvage in vivo however
HEGKEINC_01231 3e-42 gldA 1.1.1.1, 1.1.1.6 C glycerol dehydrogenase
HEGKEINC_01232 9.9e-50 gldA 1.1.1.1, 1.1.1.6 C glycerol dehydrogenase
HEGKEINC_01233 3.2e-07 gldA 1.1.1.1, 1.1.1.6 C glycerol dehydrogenase
HEGKEINC_01234 3e-183 hipO E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
HEGKEINC_01235 4.3e-234 brnQ E Component of the transport system for branched-chain amino acids
HEGKEINC_01236 9.4e-65 manA 5.3.1.8 G mannose-6-phosphate isomerase
HEGKEINC_01237 8.2e-57 manA 5.3.1.8 G mannose-6-phosphate isomerase
HEGKEINC_01238 4.8e-25 csbD K CsbD-like
HEGKEINC_01239 6.2e-228 yfnA E amino acid
HEGKEINC_01240 1.9e-109 XK27_02070 S nitroreductase
HEGKEINC_01241 9.5e-150 1.13.11.2 S glyoxalase
HEGKEINC_01242 5.6e-77 ywnA K Transcriptional regulator
HEGKEINC_01243 9.5e-158 E Alpha/beta hydrolase of unknown function (DUF915)
HEGKEINC_01244 5.6e-231 pts13C G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HEGKEINC_01245 1.4e-110 drgA C Nitroreductase
HEGKEINC_01246 5e-66 yoaK S Protein of unknown function (DUF1275)
HEGKEINC_01248 6.8e-161 yvgN C reductase
HEGKEINC_01249 1e-181 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
HEGKEINC_01250 2.8e-282 XK27_07020 S Belongs to the UPF0371 family
HEGKEINC_01252 1.1e-37 BP1961 P nitric oxide dioxygenase activity
HEGKEINC_01253 1.4e-54 K response regulator
HEGKEINC_01254 9.3e-72 S Signal peptide protein, YSIRK family
HEGKEINC_01256 4.5e-61
HEGKEINC_01257 1.8e-270 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HEGKEINC_01258 3.4e-126
HEGKEINC_01259 2.8e-10 IQ PFAM AMP-dependent synthetase and ligase
HEGKEINC_01260 2.7e-12 IQ PFAM AMP-dependent synthetase and ligase
HEGKEINC_01261 5.8e-109 MA20_06410 E LysE type translocator
HEGKEINC_01262 5.6e-08
HEGKEINC_01263 2.7e-09
HEGKEINC_01264 0.0 M family 8
HEGKEINC_01266 4.2e-20
HEGKEINC_01267 1.1e-151 V MatE
HEGKEINC_01269 3.9e-110 C Fe-S oxidoreductases
HEGKEINC_01270 1.2e-176 EGP Major Facilitator Superfamily
HEGKEINC_01271 5.5e-258 I radical SAM domain protein
HEGKEINC_01273 1.5e-36 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
HEGKEINC_01274 9.4e-115 L Transposase
HEGKEINC_01275 0.0 amiA E ABC transporter, substrate-binding protein, family 5
HEGKEINC_01276 1.2e-24 oppF P Belongs to the ABC transporter superfamily
HEGKEINC_01277 1.1e-44 oppF P Belongs to the ABC transporter superfamily
HEGKEINC_01278 1.4e-40 tatD L Hydrolase, tatd
HEGKEINC_01279 6.7e-218 oxlT P COG0477 Permeases of the major facilitator superfamily
HEGKEINC_01280 1e-110 L Integrase core domain protein
HEGKEINC_01281 1.1e-23 L transposase activity
HEGKEINC_01282 8.2e-182 pta 2.3.1.8, 3.6.3.21 C phosphate acetyltransferase
HEGKEINC_01283 9.8e-174 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 J Responsible for synthesis of pseudouridine from uracil
HEGKEINC_01284 5.4e-150 nadK 2.7.1.23 H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HEGKEINC_01285 5.5e-121 yjbM 2.7.6.5 S Gtp pyrophosphokinase
HEGKEINC_01286 1.5e-103 yjbK S Adenylate cyclase
HEGKEINC_01287 2.1e-177 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HEGKEINC_01288 7e-206 iscS 2.8.1.7 E Cysteine desulfurase
HEGKEINC_01289 2e-58 XK27_04120 S Putative amino acid metabolism
HEGKEINC_01290 3.6e-117 rex K Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HEGKEINC_01291 1.6e-131 puuD T peptidase C26
HEGKEINC_01292 4.6e-115 radC E Belongs to the UPF0758 family
HEGKEINC_01293 1.7e-268 M Psort location CytoplasmicMembrane, score
HEGKEINC_01294 0.0 rgpF M Rhamnan synthesis protein F
HEGKEINC_01295 2e-305 GT4 M transferase activity, transferring glycosyl groups
HEGKEINC_01296 6.4e-229 rgpD 3.6.3.38 P Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system
HEGKEINC_01297 2.1e-143 rgpC GM Transport permease protein
HEGKEINC_01298 4.9e-176 rgpB GT2 M Glycosyltransferase, group 2 family protein
HEGKEINC_01299 1.8e-228 rgpA GT4 M Domain of unknown function (DUF1972)
HEGKEINC_01300 8.2e-153 2.4.1.60 S Glycosyltransferase group 2 family protein
HEGKEINC_01301 4.6e-42 S Uncharacterized conserved protein (DUF2304)
HEGKEINC_01302 6.9e-130 arnC M group 2 family protein
HEGKEINC_01303 9.5e-183 cpsIaJ S Glycosyltransferase like family 2
HEGKEINC_01304 9.3e-186 S Glycosyltransferase like family 2
HEGKEINC_01305 9.4e-223 amrA S membrane protein involved in the export of O-antigen and teichoic acid
HEGKEINC_01306 6.9e-161 rfbD 1.1.1.133, 5.1.3.13 M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
HEGKEINC_01307 5.3e-237 S Predicted membrane protein (DUF2142)
HEGKEINC_01308 1.7e-173 yfdH GT2 M COG0463, glycosyltransferases involved in cell wall biogenesis
HEGKEINC_01309 3.4e-55 yitW K metal-sulfur cluster biosynthetic enzyme
HEGKEINC_01310 1.1e-201 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
HEGKEINC_01311 0.0 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
HEGKEINC_01312 5.5e-20 rpsU J Belongs to the bacterial ribosomal protein bS21 family
HEGKEINC_01313 1.6e-135 gltS ET Belongs to the bacterial solute-binding protein 3 family
HEGKEINC_01314 1.4e-201 arcT 2.6.1.1 E Aminotransferase
HEGKEINC_01315 2.5e-136 ET ABC transporter
HEGKEINC_01316 3.7e-143 ET Belongs to the bacterial solute-binding protein 3 family
HEGKEINC_01317 2.9e-84 mutT 3.6.1.55 F Nudix family
HEGKEINC_01318 0.0 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
HEGKEINC_01320 7.6e-78 S CAAX amino terminal protease family protein
HEGKEINC_01321 7.6e-32 S CAAX amino terminal protease family protein
HEGKEINC_01322 0.0 glnP P ABC-type amino acid transport signal transduction systems periplasmic component domain
HEGKEINC_01323 1e-136 glnQ 3.6.3.21 E abc transporter atp-binding protein
HEGKEINC_01324 1.1e-16 XK27_00735
HEGKEINC_01325 1.4e-248 obg S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HEGKEINC_01327 2.1e-134 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
HEGKEINC_01330 1.2e-64 paaI Q protein possibly involved in aromatic compounds catabolism
HEGKEINC_01331 3e-37 ycaO O OsmC-like protein
HEGKEINC_01333 1.7e-154 EG Permeases of the drug metabolite transporter (DMT) superfamily
HEGKEINC_01335 5.6e-110 csn2 S CRISPR-associated protein (Cas_Csn2)
HEGKEINC_01336 3.5e-52 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HEGKEINC_01337 1.5e-163 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HEGKEINC_01338 0.0 cas9 L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
HEGKEINC_01339 6.7e-116 serB 3.1.3.3 E phosphoserine phosphatase
HEGKEINC_01340 1.1e-301 ezrA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HEGKEINC_01341 0.0 gyrB 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HEGKEINC_01342 2.6e-109 3.1.3.18 S IA, variant 1
HEGKEINC_01343 2.2e-117 lrgB M effector of murein hydrolase
HEGKEINC_01344 7.7e-56 lrgA S Effector of murein hydrolase LrgA
HEGKEINC_01346 6.4e-60 arsC 1.20.4.1 P Belongs to the ArsC family
HEGKEINC_01347 6.3e-57 ogt 2.1.1.63, 3.2.2.20 L methylated-DNA-[protein]-cysteine S-methyltransferase activity
HEGKEINC_01348 1.1e-220 serA 1.1.1.399, 1.1.1.95 EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HEGKEINC_01349 3.9e-104 wecD M Acetyltransferase GNAT family
HEGKEINC_01350 1.3e-209 serC 2.6.1.52 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HEGKEINC_01351 5.1e-96 GK ROK family
HEGKEINC_01352 8.1e-72 gloA 4.4.1.5 E Lactoylglutathione lyase
HEGKEINC_01353 1.5e-142 XK27_08050 O HflC and HflK could regulate a protease
HEGKEINC_01354 2.3e-206 potD P spermidine putrescine ABC transporter
HEGKEINC_01355 3.3e-133 potC P ABC-type spermidine putrescine transport system, permease component II
HEGKEINC_01356 2.4e-139 potB P ABC-type spermidine putrescine transport system, permease component I
HEGKEINC_01357 1.2e-213 potA 3.6.3.30, 3.6.3.31 P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
HEGKEINC_01358 7.8e-171 murB 1.3.1.98 M cell wall formation
HEGKEINC_01359 2.9e-87 folK 2.7.6.3, 4.1.2.25 H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HEGKEINC_01360 1.2e-61 folB 1.13.11.81, 2.5.1.15, 2.7.6.3, 4.1.2.25, 5.1.99.8 H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HEGKEINC_01361 1.2e-298 amy 3.2.1.1 GH13 G Belongs to the glycosyl hydrolase 13 family
HEGKEINC_01362 1.2e-146 folP 2.5.1.15, 2.7.6.3 H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HEGKEINC_01363 1e-99 folE 3.5.4.16 F gtp cyclohydrolase
HEGKEINC_01364 0.0 ydaO E amino acid
HEGKEINC_01365 5.5e-239 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
HEGKEINC_01366 4.1e-37 ylqC L Belongs to the UPF0109 family
HEGKEINC_01367 2.4e-43 rpsP J Belongs to the bacterial ribosomal protein bS16 family
HEGKEINC_01368 4.5e-171 tehB 2.1.1.265 PQ tellurite resistance protein tehb
HEGKEINC_01369 2e-157 xth 3.1.11.2 L exodeoxyribonuclease III
HEGKEINC_01370 2.1e-74 S QueT transporter
HEGKEINC_01371 2.5e-08 ribD 1.1.1.193, 3.5.4.26 L Transposase DDE domain
HEGKEINC_01372 1.1e-89 ribD 1.1.1.193, 3.5.4.26 L Transposase DDE domain
HEGKEINC_01373 1.9e-186 yegS 2.7.1.107 I Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
HEGKEINC_01374 0.0 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HEGKEINC_01375 2.2e-85 ccl S cog cog4708
HEGKEINC_01376 5.8e-161 rbn E Belongs to the UPF0761 family
HEGKEINC_01377 1.9e-166 map 3.4.11.18 E Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed
HEGKEINC_01378 3e-232 ytoI K transcriptional regulator containing CBS domains
HEGKEINC_01379 1.1e-98 XK27_07830 2.3.1.128 J Acetyltransferase GNAT Family
HEGKEINC_01380 1.5e-233 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HEGKEINC_01381 0.0 comEC S Competence protein ComEC
HEGKEINC_01382 3e-98 comEA L COG1555 DNA uptake protein and related DNA-binding proteins
HEGKEINC_01383 1.5e-119 Z012_04635 K Helix-turn-helix XRE-family like proteins
HEGKEINC_01385 2.7e-112 C 4Fe-4S single cluster domain
HEGKEINC_01386 2.5e-139 C Iron-sulfur cluster-binding domain
HEGKEINC_01388 9.2e-156 V AAA domain, putative AbiEii toxin, Type IV TA system
HEGKEINC_01389 2e-55 S ABC-2 type transporter
HEGKEINC_01390 2.8e-97
HEGKEINC_01391 1.1e-23
HEGKEINC_01392 1.9e-141 plsC 2.3.1.51 I Acyltransferase
HEGKEINC_01393 5.4e-79 nodB3 G polysaccharide deacetylase
HEGKEINC_01394 5.9e-48 nodB3 G polysaccharide deacetylase
HEGKEINC_01395 2.1e-110 yabB 2.1.1.223 L Methyltransferase
HEGKEINC_01396 3.3e-58 yabB 2.1.1.223 L Methyltransferase
HEGKEINC_01397 1e-41 yazA L endonuclease containing a URI domain
HEGKEINC_01398 1.3e-237 cshA 3.6.4.13 JKL DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
HEGKEINC_01399 7.4e-145 corA P CorA-like protein
HEGKEINC_01400 2.5e-62 yjqA S Bacterial PH domain
HEGKEINC_01401 7.8e-100 thiT S Thiamine transporter
HEGKEINC_01402 2.1e-157 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
HEGKEINC_01403 2.4e-64 yjbB G Permeases of the major facilitator superfamily
HEGKEINC_01404 1.4e-84 yjbB G Permeases of the major facilitator superfamily
HEGKEINC_01405 2.8e-289 prfC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HEGKEINC_01406 1.4e-121 ywaF S Integral membrane protein (intg_mem_TP0381)
HEGKEINC_01407 3e-259 murF 6.3.2.10 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
HEGKEINC_01411 1.1e-155 cjaA ET ABC transporter substrate-binding protein
HEGKEINC_01412 1.4e-136 glnQ 3.6.3.21 E abc transporter atp-binding protein
HEGKEINC_01413 4.6e-115 P ABC transporter (Permease
HEGKEINC_01414 1e-114 papP P ABC transporter (Permease
HEGKEINC_01415 1.7e-193 ddl 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
HEGKEINC_01416 4.7e-31 copZ 2.7.7.77 P Heavy metal-associated domain protein
HEGKEINC_01417 0.0 copA 3.6.3.54 P P-type ATPase
HEGKEINC_01418 3.2e-74 copY K Copper transport repressor, CopY TcrY family
HEGKEINC_01419 1.2e-143 trpA 4.2.1.20 E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
HEGKEINC_01420 5.8e-230 trpB 4.2.1.20, 5.3.1.24 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HEGKEINC_01421 1.4e-101 trpF 4.1.1.48, 4.2.1.160, 4.2.1.20, 5.3.1.24 E belongs to the TrpF family
HEGKEINC_01422 8.5e-134 trpC 4.1.1.48, 5.3.1.24 E Belongs to the TrpC family
HEGKEINC_01423 3.3e-178 trpD 2.4.2.18, 4.1.3.27 F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HEGKEINC_01424 1.2e-105 trpG 2.4.2.18, 2.6.1.85, 4.1.3.27 EH anthranilate
HEGKEINC_01425 8.7e-259 trpE 4.1.3.27 EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HEGKEINC_01426 3.7e-42 pchB 2.5.1.19, 4.2.1.10, 4.2.99.21, 5.4.99.5 E Chorismate mutase
HEGKEINC_01427 1.4e-54
HEGKEINC_01428 0.0 ctpE P E1-E2 ATPase
HEGKEINC_01429 6.2e-28
HEGKEINC_01430 1.2e-43 yaaK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HEGKEINC_01431 5.1e-47 L transposase activity
HEGKEINC_01432 1e-128 K transcriptional regulator, MerR family
HEGKEINC_01433 1.4e-104 dnaQ 2.7.7.7 L DNA polymerase III
HEGKEINC_01434 1.2e-41 WQ51_02910 S Protein of unknown function, DUF536
HEGKEINC_01435 1.6e-63 XK27_02560 S cog cog2151
HEGKEINC_01436 0.0 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
HEGKEINC_01437 7.7e-227 ytfP S Flavoprotein
HEGKEINC_01439 3.1e-121 trmB 2.1.1.297, 2.1.1.33 J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
HEGKEINC_01440 1.2e-151 ytmP 2.7.1.89 M Phosphotransferase
HEGKEINC_01441 4.3e-181 ecsB U ABC transporter
HEGKEINC_01442 1.2e-132 ecsA V abc transporter atp-binding protein
HEGKEINC_01443 1.9e-71 hit FG Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
HEGKEINC_01444 2.3e-10
HEGKEINC_01445 2.7e-57 S CD20-like family
HEGKEINC_01446 5.2e-105
HEGKEINC_01447 0.0 clpL O ATP-dependent Clp protease ATP-binding subunit
HEGKEINC_01448 6.9e-206 ylbM S Belongs to the UPF0348 family
HEGKEINC_01449 2e-140 yqeM Q Methyltransferase domain protein
HEGKEINC_01450 6e-58 rsfS J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
HEGKEINC_01451 1.4e-107 nadD 2.7.6.3, 2.7.7.18 H HD superfamily hydrolase involved in NAD metabolism
HEGKEINC_01452 3.1e-118 nadD 2.7.7.18, 3.6.1.55 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HEGKEINC_01453 3.5e-49 yhbY J RNA-binding protein
HEGKEINC_01454 1.7e-215 yqeH S in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis
HEGKEINC_01455 1.8e-98 yqeG S hydrolase of the HAD superfamily
HEGKEINC_01456 1.3e-152 yicL EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
HEGKEINC_01457 1.3e-57
HEGKEINC_01458 2.3e-273 gatB 6.1.1.12, 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HEGKEINC_01459 1.7e-268 gatA 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
HEGKEINC_01460 1.4e-47 gatC 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HEGKEINC_01461 1.5e-258 ascB 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
HEGKEINC_01462 4.7e-96 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HEGKEINC_01463 4.8e-154 hlpA M Belongs to the NlpA lipoprotein family
HEGKEINC_01464 6.8e-101 pncA Q isochorismatase
HEGKEINC_01465 1.2e-140 codY K DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HEGKEINC_01466 3.7e-240 alaA 2.6.1.2, 2.6.1.66 E Aminotransferase
HEGKEINC_01467 2.4e-75 XK27_03180 T universal stress protein
HEGKEINC_01470 2e-157 pflA 1.97.1.4 C Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HEGKEINC_01471 7.1e-237 hlyX S COG1253 Hemolysins and related proteins containing CBS domains
HEGKEINC_01472 2.4e-144 modF 3.6.3.21, 3.6.3.34 P abc transporter atp-binding protein
HEGKEINC_01473 0.0 yjcE P NhaP-type Na H and K H antiporters
HEGKEINC_01475 1.4e-98 ytqB 2.1.1.176 J (SAM)-dependent
HEGKEINC_01476 1.3e-184 yhcC S radical SAM protein
HEGKEINC_01477 2.2e-196 ylbL T Belongs to the peptidase S16 family
HEGKEINC_01478 5.9e-88 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HEGKEINC_01479 5.1e-93 rsmD 2.1.1.171 L Methyltransferase
HEGKEINC_01480 1.9e-172 trxB 1.8.1.9 C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
HEGKEINC_01481 1.9e-09 S Protein of unknown function (DUF4059)
HEGKEINC_01482 4.5e-132 tcyN 3.6.3.21 E abc transporter atp-binding protein
HEGKEINC_01483 1e-162 yxeN P ABC transporter (Permease
HEGKEINC_01484 2.6e-152 yxeM ET ABC-type amino acid transport signal transduction systems, periplasmic component domain
HEGKEINC_01486 3.1e-206 dinB 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HEGKEINC_01487 0.0 pflB 2.3.1.54 C formate acetyltransferase'
HEGKEINC_01488 1.8e-147 cah 4.2.1.1 P carbonic anhydrase
HEGKEINC_01489 2.1e-85 yjcF S COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HEGKEINC_01490 1e-44 hsdS_1 3.1.21.3 V type I restriction modification DNA specificity domain
HEGKEINC_01491 2.9e-87 D nuclear chromosome segregation
HEGKEINC_01492 1.5e-127 ybbM S transport system, permease component
HEGKEINC_01493 1.2e-117 ybbL S abc transporter atp-binding protein
HEGKEINC_01494 4.5e-185 ampC V COG1680 Beta-lactamase class C and other penicillin binding proteins
HEGKEINC_01495 4.6e-140 cppA E CppA N-terminal
HEGKEINC_01496 5e-44 V CAAX protease self-immunity
HEGKEINC_01497 2.3e-164 gla U Belongs to the MIP aquaporin (TC 1.A.8) family
HEGKEINC_01498 0.0 pepX 3.4.14.11 E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline
HEGKEINC_01501 3e-47 spiA K sequence-specific DNA binding
HEGKEINC_01502 9.5e-140 blpT
HEGKEINC_01506 5.1e-122 L Transposase
HEGKEINC_01507 6.2e-165 L integrase core domain
HEGKEINC_01512 6.7e-26 S Bacteriocin class II with double-glycine leader peptide
HEGKEINC_01516 7.4e-135 agrA KT phosphorelay signal transduction system
HEGKEINC_01517 9.9e-239 blpH 2.7.13.3 T protein histidine kinase activity
HEGKEINC_01519 7.3e-237 mesE M Transport protein ComB
HEGKEINC_01520 0.0 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
HEGKEINC_01521 0.0 mdlB V abc transporter atp-binding protein
HEGKEINC_01522 0.0 mdlA V abc transporter atp-binding protein
HEGKEINC_01524 1.7e-93 XK27_09885 V Glycopeptide antibiotics resistance protein
HEGKEINC_01525 7.9e-224 rlmN 2.1.1.192 J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HEGKEINC_01526 3.6e-70 yutD J protein conserved in bacteria
HEGKEINC_01527 5.1e-270 yunD 3.1.3.5 F Belongs to the 5'-nucleotidase family
HEGKEINC_01529 7.2e-221 cshB 3.6.4.13 JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
HEGKEINC_01530 6.3e-185 mraY 2.7.8.13 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HEGKEINC_01531 0.0 ftsI 3.4.16.4 M penicillin-binding protein
HEGKEINC_01532 4.3e-47 ftsL D cell division protein FtsL
HEGKEINC_01533 1.6e-175 rsmH 2.1.1.199 J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
HEGKEINC_01534 3e-128
HEGKEINC_01535 9.7e-32 yhaI J Protein of unknown function (DUF805)
HEGKEINC_01536 1.3e-08 D nuclear chromosome segregation
HEGKEINC_01537 2e-225 proA 1.2.1.41 E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HEGKEINC_01538 5.7e-141 proB 2.7.2.11 E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HEGKEINC_01539 2.2e-285 XK27_00765
HEGKEINC_01540 8.1e-134 ecsA_2 V abc transporter atp-binding protein
HEGKEINC_01541 5.2e-125 S Protein of unknown function (DUF554)
HEGKEINC_01542 0.0 addA 3.6.4.12 L ATP-dependent helicase nuclease subunit A
HEGKEINC_01543 0.0 rexB 3.1.21.3, 3.6.4.12 L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HEGKEINC_01544 2.6e-121 liaI S membrane
HEGKEINC_01545 5.2e-75 XK27_02470 K LytTr DNA-binding domain
HEGKEINC_01546 3.6e-66 KT response to antibiotic
HEGKEINC_01547 2e-80 yebC M Membrane
HEGKEINC_01548 2.9e-18 yebC M Membrane
HEGKEINC_01549 2.8e-260 XK27_03190 5.2.1.8 S hydrolases of the HAD superfamily
HEGKEINC_01550 2.2e-179 ansA 3.5.1.1 EJ COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D
HEGKEINC_01551 0.0 recG 3.6.4.12 L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HEGKEINC_01552 6.8e-185 alr 5.1.1.1, 5.1.1.5 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HEGKEINC_01553 4.5e-61 acpS 2.7.6.3, 2.7.8.7, 5.1.1.1 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
HEGKEINC_01554 1.1e-197 aroF 2.5.1.54 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HEGKEINC_01555 2.9e-198 aroF 2.5.1.54 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HEGKEINC_01556 0.0 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
HEGKEINC_01558 3e-189 manA 5.3.1.8 G mannose-6-phosphate isomerase
HEGKEINC_01559 4.1e-172 scrK 2.7.1.2, 2.7.1.4 GK Fructokinase
HEGKEINC_01560 0.0 scrA 2.7.1.211 G pts system
HEGKEINC_01561 5.4e-291 scrB 3.2.1.26 GH32 G invertase
HEGKEINC_01562 7.5e-180 scrR K Transcriptional
HEGKEINC_01563 2.1e-73 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HEGKEINC_01564 3.4e-62 yqhY S protein conserved in bacteria
HEGKEINC_01565 1.2e-97 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HEGKEINC_01566 3.7e-84 comEB 3.5.4.12 F ComE operon protein 2
HEGKEINC_01567 5e-193 pepP 3.4.11.9, 3.4.13.9 E Belongs to the peptidase M24B family
HEGKEINC_01569 8e-44 V 'abc transporter, ATP-binding protein
HEGKEINC_01570 1e-58 V 'abc transporter, ATP-binding protein
HEGKEINC_01573 0.0 uvrA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HEGKEINC_01574 2e-169 corA P COG0598 Mg2 and Co2 transporters
HEGKEINC_01575 3.1e-124 XK27_01040 S Pfam PF06570
HEGKEINC_01577 9.7e-36 rpsR J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HEGKEINC_01578 2.7e-91 ssb L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
HEGKEINC_01579 3.9e-47 rpsF J Binds together with S18 to 16S ribosomal RNA
HEGKEINC_01580 3.6e-41 XK27_05745
HEGKEINC_01581 9.5e-230 mutY L A G-specific adenine glycosylase
HEGKEINC_01586 0.0 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HEGKEINC_01587 0.0 mutS2 L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
HEGKEINC_01588 1e-93 cvpA S toxin biosynthetic process
HEGKEINC_01589 2.3e-13 zapA D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HEGKEINC_01590 4.7e-160 rnhC 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HEGKEINC_01591 1.3e-113 lepB 3.4.21.89 U Belongs to the peptidase S26 family
HEGKEINC_01592 0.0 recD2 3.1.11.5 L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
HEGKEINC_01593 8.8e-48 azlD E branched-chain amino acid
HEGKEINC_01594 2.5e-116 azlC E AzlC protein
HEGKEINC_01595 1.9e-186 tsaD 2.3.1.234 O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HEGKEINC_01596 1.3e-73 rimI 2.3.1.128 K This enzyme acetylates the N-terminal alanine of ribosomal protein S18
HEGKEINC_01597 4.3e-121 yeaZ 2.3.1.234 O COG1214, inactive homolog of metal-dependent proteases
HEGKEINC_01598 2.5e-33 ykzG S Belongs to the UPF0356 family
HEGKEINC_01599 0.0 rnjA S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HEGKEINC_01600 2.7e-40 pscB M CHAP domain protein
HEGKEINC_01601 1.5e-263 glnA 6.3.1.2 E glutamine synthetase
HEGKEINC_01602 8.5e-63 glnR K Transcriptional regulator
HEGKEINC_01603 1.3e-87 S Fusaric acid resistance protein-like
HEGKEINC_01604 1.1e-12
HEGKEINC_01605 2e-222 pgk 2.7.2.3, 5.3.1.1 F Belongs to the phosphoglycerate kinase family
HEGKEINC_01606 3.2e-42 L Transposase
HEGKEINC_01607 1.9e-46 L transposase activity
HEGKEINC_01608 1.3e-22 L Transposase
HEGKEINC_01609 1.4e-189 gap 1.2.1.12 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
HEGKEINC_01610 0.0 fusA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HEGKEINC_01611 6.7e-81 rpsG J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
HEGKEINC_01612 2.3e-69 rpsL J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HEGKEINC_01613 1.1e-142 purR 2.4.2.7 F operon repressor
HEGKEINC_01614 3.6e-179 cbf S 3'-5' exoribonuclease yhaM
HEGKEINC_01615 6.9e-173 rmuC S RmuC domain protein
HEGKEINC_01616 3.1e-118 thiN 2.7.6.2 H thiamine pyrophosphokinase
HEGKEINC_01617 3e-119 rpe 5.1.3.1 G Belongs to the ribulose-phosphate 3-epimerase family
HEGKEINC_01618 6.4e-162 rsgA 3.1.3.100 G One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
HEGKEINC_01620 8.9e-156 ksgA 2.1.1.182 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
HEGKEINC_01621 1.1e-98 rnmV 3.1.26.8 J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HEGKEINC_01622 2.2e-142 tatD L Hydrolase, tatd
HEGKEINC_01623 2.5e-74 yccU S CoA-binding protein
HEGKEINC_01624 4.8e-51 trxA O Belongs to the thioredoxin family
HEGKEINC_01625 7.8e-143 S Macro domain protein
HEGKEINC_01626 3.1e-10 L thioesterase
HEGKEINC_01627 1.3e-54 bta 1.8.1.8 CO cell redox homeostasis
HEGKEINC_01629 1.7e-226 tgt 2.4.2.29 F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
HEGKEINC_01630 5e-84 L Transposase
HEGKEINC_01631 1e-13 rpmH J Ribosomal protein L34
HEGKEINC_01632 5.5e-184 jag S RNA-binding protein
HEGKEINC_01633 1.7e-140 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HEGKEINC_01634 1.2e-55 rnpA 3.1.26.5 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
HEGKEINC_01635 5.4e-264 argH 4.3.2.1 E Argininosuccinate lyase
HEGKEINC_01636 2e-230 argG 6.3.4.5 E Belongs to the argininosuccinate synthase family. Type 1 subfamily
HEGKEINC_01637 2.1e-282 gltX 6.1.1.17, 6.1.1.24 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HEGKEINC_01638 6.7e-81 amiA E transmembrane transport
HEGKEINC_01639 2e-41 amiA E transmembrane transport
HEGKEINC_01640 4.2e-90 amiA E ABC transporter, substrate-binding protein, family 5
HEGKEINC_01641 7.8e-28 amiA E ABC transporter, substrate-binding protein, family 5
HEGKEINC_01642 4.8e-120 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
HEGKEINC_01643 3.7e-70 rplK J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HEGKEINC_01644 9.2e-51 S Protein of unknown function (DUF3397)
HEGKEINC_01645 2e-88 cah 4.2.1.1 P Reversible hydration of carbon dioxide
HEGKEINC_01646 9.3e-34 WQ51_05710 S Mitochondrial biogenesis AIM24
HEGKEINC_01647 6.8e-32 WQ51_05710 S Mitochondrial biogenesis AIM24
HEGKEINC_01648 6.2e-12 WQ51_05710 S Mitochondrial biogenesis AIM24
HEGKEINC_01649 1.4e-226 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HEGKEINC_01650 1.1e-80 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
HEGKEINC_01651 4.7e-20 XK27_09620 S FMN reductase (NADPH) activity
HEGKEINC_01652 4.3e-77 XK27_09620 S reductase
HEGKEINC_01653 2.1e-32 XK27_09615 S FMN reductase (NADPH) activity
HEGKEINC_01654 4.4e-117 XK27_09615 C reductase
HEGKEINC_01655 8.1e-91 fnt P Formate nitrite transporter
HEGKEINC_01656 6.5e-83 XK27_08585 S Psort location CytoplasmicMembrane, score
HEGKEINC_01657 7.4e-186 gpsA 1.1.1.94 I Glycerol-3-phosphate dehydrogenase
HEGKEINC_01658 5.1e-170 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
HEGKEINC_01659 5.2e-119 gluP 3.4.21.105 O membrane protein (homolog of Drosophila rhomboid)
HEGKEINC_01660 9.1e-95 ygfA 6.3.3.2 H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HEGKEINC_01661 7.9e-221 hipO 3.5.1.47 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
HEGKEINC_01662 8.1e-59 dapD 2.3.1.117, 2.3.1.89 E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
HEGKEINC_01663 6e-48 S glycolate biosynthetic process
HEGKEINC_01664 1.5e-64 S phosphatase activity
HEGKEINC_01665 6.3e-159 rrmA 2.1.1.187 Q methyltransferase
HEGKEINC_01668 1.2e-91 tadA 3.5.4.1, 3.5.4.33 FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
HEGKEINC_01669 5.1e-66 ssb_2 L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
HEGKEINC_01670 8.3e-37 yeeD O sulfur carrier activity
HEGKEINC_01671 7.8e-191 yeeE S Sulphur transport
HEGKEINC_01672 1.8e-113 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HEGKEINC_01673 2.1e-54 ytpP 2.7.1.180, 5.3.4.1 CO Thioredoxin
HEGKEINC_01674 1.2e-08 S Domain of unknown function (DUF4651)
HEGKEINC_01675 5.7e-205 pepA 3.4.11.7 G COG1363 Cellulase M and related proteins
HEGKEINC_01676 3.9e-131 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HEGKEINC_01677 3.9e-111 S CAAX amino terminal protease family protein
HEGKEINC_01679 5e-67 V CAAX protease self-immunity
HEGKEINC_01680 1.4e-33 V CAAX protease self-immunity
HEGKEINC_01681 8.8e-27 lanR K sequence-specific DNA binding
HEGKEINC_01682 1.1e-220 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HEGKEINC_01683 4.2e-175 ytxK 2.1.1.72 L DNA methylase
HEGKEINC_01684 2.2e-11 comGF U Putative Competence protein ComGF
HEGKEINC_01685 1.3e-70 comGF U Competence protein ComGF
HEGKEINC_01686 1.4e-15 NU Type II secretory pathway pseudopilin
HEGKEINC_01687 2.6e-56 cglD NU Competence protein
HEGKEINC_01688 2.5e-42 comGC U Required for transformation and DNA binding
HEGKEINC_01689 5.4e-153 cglB U protein transport across the cell outer membrane
HEGKEINC_01690 2.2e-176 comGA NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HEGKEINC_01691 3.2e-67 S cog cog4699
HEGKEINC_01692 0.0 rpoC 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HEGKEINC_01693 0.0 rpoB 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HEGKEINC_01694 0.0 pbp1B 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
HEGKEINC_01695 1.6e-238 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HEGKEINC_01696 1.6e-196 ilvC 1.1.1.86 H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HEGKEINC_01697 7.7e-77 ilvN 2.2.1.6 E Acetolactate synthase
HEGKEINC_01698 0.0 ilvB 2.2.1.6 EH Acetolactate synthase
HEGKEINC_01699 1.6e-249 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
HEGKEINC_01700 8.4e-09 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
HEGKEINC_01701 1.7e-304 yloV S kinase related to dihydroxyacetone kinase
HEGKEINC_01702 1.8e-57 asp S cog cog1302
HEGKEINC_01703 3.2e-226 norN V Mate efflux family protein
HEGKEINC_01704 1.9e-278 thrC 4.2.3.1 E Threonine synthase
HEGKEINC_01705 3.2e-65 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
HEGKEINC_01706 8e-35 adhE 1.1.1.1, 1.2.1.10 C hydroxyacid-oxoacid transhydrogenase activity
HEGKEINC_01707 1.1e-65 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
HEGKEINC_01708 6.3e-132 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
HEGKEINC_01709 3.1e-63 adhE 1.1.1.1, 1.2.1.10 C Dehydrogenase
HEGKEINC_01710 0.0 pepO 3.4.24.71 O Peptidase family M13
HEGKEINC_01711 2.8e-38 treC 3.2.1.93 GH13 G COG0366 Glycosidases
HEGKEINC_01712 1.2e-69 treC 3.2.1.93 GH13 G COG0366 Glycosidases
HEGKEINC_01713 5.9e-66 treC 3.2.1.93 GH13 G COG0366 Glycosidases
HEGKEINC_01714 1.4e-54 treB 2.7.1.201 G PTS System
HEGKEINC_01715 5.8e-21 treR K DNA-binding transcription factor activity
HEGKEINC_01716 1.2e-85 treR K trehalose operon
HEGKEINC_01717 3.3e-95 ywlG S Belongs to the UPF0340 family
HEGKEINC_01719 2.7e-13 L PFAM Integrase, catalytic core
HEGKEINC_01720 1e-140 L DNA integration
HEGKEINC_01721 9e-164 fba 4.1.2.13, 4.1.2.29 G aldolase
HEGKEINC_01723 6.7e-110 6.3.2.2 H ergothioneine biosynthetic process
HEGKEINC_01724 9.6e-65 6.3.2.2 H gamma-glutamylcysteine synthetase
HEGKEINC_01725 2.2e-12 6.3.2.2 H gamma-glutamylcysteine synthetase
HEGKEINC_01726 1.9e-33 L PFAM Integrase, catalytic core
HEGKEINC_01727 3.3e-62 rplQ J ribosomal protein l17
HEGKEINC_01728 4.8e-171 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HEGKEINC_01729 9.6e-62 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HEGKEINC_01730 4e-57 rpsM J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HEGKEINC_01731 6e-15 rpmJ J Belongs to the bacterial ribosomal protein bL36 family
HEGKEINC_01732 2.7e-32 infA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HEGKEINC_01733 9.2e-121 adk 2.7.4.3 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
HEGKEINC_01734 3.3e-231 secY U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
HEGKEINC_01735 7.4e-58 rplO J binds to the 23S rRNA
HEGKEINC_01736 2.5e-23 rpmD J ribosomal protein l30
HEGKEINC_01737 1.7e-79 rpsE J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HEGKEINC_01738 1.9e-56 rplR J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HEGKEINC_01739 2.3e-93 rplF J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HEGKEINC_01740 1.2e-67 rpsH J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HEGKEINC_01741 1.5e-28 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HEGKEINC_01742 1.6e-94 rplE J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HEGKEINC_01743 4.1e-47 rplX J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HEGKEINC_01744 1.1e-59 rplN J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HEGKEINC_01745 6e-39 rpsQ J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HEGKEINC_01746 2.7e-26 rpmC J Belongs to the universal ribosomal protein uL29 family
HEGKEINC_01747 7.2e-71 rplP J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HEGKEINC_01748 2.1e-117 rpsC J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HEGKEINC_01749 7.3e-53 rplV J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HEGKEINC_01750 4.9e-47 rpsS J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HEGKEINC_01751 8.8e-153 rplB J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HEGKEINC_01752 2.4e-44 rplW J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
HEGKEINC_01753 5.7e-104 rplD J Forms part of the polypeptide exit tunnel
HEGKEINC_01754 1.1e-110 rplC J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HEGKEINC_01755 1.3e-48 rpsJ J Involved in the binding of tRNA to the ribosomes
HEGKEINC_01756 7.8e-188 ruvB 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
HEGKEINC_01757 0.0 XK27_09800 I Acyltransferase
HEGKEINC_01758 1.7e-35 XK27_09805 S MORN repeat protein
HEGKEINC_01759 1e-80 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HEGKEINC_01760 4.1e-250 purA 6.3.4.4 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HEGKEINC_01761 8.8e-83 adk 2.7.4.3 F topology modulation protein
HEGKEINC_01762 3.1e-172 yxaM EGP Major facilitator Superfamily
HEGKEINC_01763 1.9e-197 2.7.7.73, 2.7.7.80 H Involved in molybdopterin and thiamine biosynthesis, family 2
HEGKEINC_01765 3.4e-155 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
HEGKEINC_01766 0.0 KLT serine threonine protein kinase
HEGKEINC_01767 3.1e-67 V ABC transporter
HEGKEINC_01768 1.2e-197 V ABC transporter
HEGKEINC_01769 1.1e-15 Z012_04635 K sequence-specific DNA binding
HEGKEINC_01770 2.7e-12 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
HEGKEINC_01771 5.3e-41 Z012_04635 K sequence-specific DNA binding
HEGKEINC_01772 1.1e-101 Z012_04635 K sequence-specific DNA binding
HEGKEINC_01774 1.6e-53 C Radical SAM
HEGKEINC_01775 1.3e-159 C Radical SAM
HEGKEINC_01776 5.1e-287 V ABC transporter transmembrane region
HEGKEINC_01777 2.5e-89 K sequence-specific DNA binding
HEGKEINC_01778 2.2e-132 int L Belongs to the 'phage' integrase family
HEGKEINC_01780 5.2e-237 rarA L ATPase related to the helicase subunit of the Holliday junction resolvase
HEGKEINC_01781 8.4e-27 rpmB J Belongs to the bacterial ribosomal protein bL28 family
HEGKEINC_01782 2.8e-44 yrzL S Belongs to the UPF0297 family
HEGKEINC_01783 1.2e-70 yqgF L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HEGKEINC_01784 4.2e-44 yrzB S Belongs to the UPF0473 family
HEGKEINC_01785 4e-298 ccs S the current gene model (or a revised gene model) may contain a frame shift
HEGKEINC_01786 0.0 nrdD 1.1.98.6 F Ribonucleoside-triphosphate reductase
HEGKEINC_01787 7.5e-14
HEGKEINC_01788 2.6e-91 XK27_10930 K acetyltransferase
HEGKEINC_01789 3.7e-116 nrdG 1.97.1.4 O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HEGKEINC_01790 4.1e-147 yaaA S Belongs to the UPF0246 family
HEGKEINC_01791 2.7e-166 XK27_01785 S cog cog1284
HEGKEINC_01792 0.0 aspS 6.1.1.12 J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
HEGKEINC_01794 1.6e-241 hisS 6.1.1.21 J histidyl-tRNA synthetase
HEGKEINC_01795 3e-53 metE 2.1.1.14 E Methionine synthase
HEGKEINC_01796 4.4e-54 metE 2.1.1.14 E Methionine synthase
HEGKEINC_01797 1.4e-36 metE 2.1.1.14 E Methionine synthase
HEGKEINC_01798 2e-25 rpmF J Belongs to the bacterial ribosomal protein bL32 family
HEGKEINC_01799 6.7e-19 rpmG J Belongs to the bacterial ribosomal protein bL33 family
HEGKEINC_01801 3.1e-20 yegS 2.7.1.107 I lipid kinase activity
HEGKEINC_01802 2.7e-95 S Hydrophobic domain protein
HEGKEINC_01804 3.7e-27 S Membrane
HEGKEINC_01805 3.1e-101
HEGKEINC_01806 1.8e-23 S Small integral membrane protein
HEGKEINC_01807 1.1e-71 M Protein conserved in bacteria
HEGKEINC_01808 4.9e-12 K CsbD-like
HEGKEINC_01809 7.2e-95 nudL L hydrolase
HEGKEINC_01810 3.4e-13 nudL L hydrolase
HEGKEINC_01811 4e-19 K negative regulation of transcription, DNA-templated
HEGKEINC_01812 1.7e-23 K negative regulation of transcription, DNA-templated
HEGKEINC_01814 3.1e-19 XK27_06920 S Protein of unknown function (DUF1700)
HEGKEINC_01815 1.8e-88 S Putative adhesin
HEGKEINC_01816 3.9e-161 XK27_06930 V domain protein
HEGKEINC_01817 6.4e-96 XK27_06935 K transcriptional regulator
HEGKEINC_01818 4.8e-55 ypaA M Membrane
HEGKEINC_01819 2e-07
HEGKEINC_01820 9.8e-109 rpsD J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HEGKEINC_01821 8.2e-48 veg S Biofilm formation stimulator VEG
HEGKEINC_01822 1.5e-245 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
HEGKEINC_01823 3.9e-70 rplI J binds to the 23S rRNA
HEGKEINC_01824 0.0 yybT T signaling protein consisting of a modified GGDEF domain and a DHH domain
HEGKEINC_01825 0.0 gidA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
HEGKEINC_01826 2.1e-218 mnmA 2.8.1.13 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
HEGKEINC_01827 0.0 S Bacterial membrane protein, YfhO
HEGKEINC_01828 5e-61 isaA GH23 M Immunodominant staphylococcal antigen A
HEGKEINC_01829 5.3e-85 lytE M LysM domain protein
HEGKEINC_01830 2.2e-137 ecfT P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HEGKEINC_01831 5.2e-153 ecfA2 3.6.3.55 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HEGKEINC_01832 1.5e-152 ecfA1 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HEGKEINC_01833 3.1e-90 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HEGKEINC_01834 1.8e-137 ymfM S sequence-specific DNA binding
HEGKEINC_01835 1.5e-178 ymfH S Peptidase M16
HEGKEINC_01836 4e-38 ymfH S Peptidase M16
HEGKEINC_01837 4e-234 ymfF S Peptidase M16
HEGKEINC_01838 1.6e-45 yaaA S S4 domain protein YaaA
HEGKEINC_01839 5.9e-205 recF L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HEGKEINC_01840 1.5e-275 guaB 1.1.1.205 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
HEGKEINC_01841 6.3e-193 trpS 6.1.1.2 J Tryptophanyl-tRNA synthetase
HEGKEINC_01842 4.2e-153 yvjA S membrane
HEGKEINC_01843 6.7e-306 ybiT S abc transporter atp-binding protein
HEGKEINC_01844 0.0 XK27_10405 S Bacterial membrane protein YfhO
HEGKEINC_01848 6.2e-120 yoaK S Psort location CytoplasmicMembrane, score
HEGKEINC_01849 1.1e-86 rlmH 2.1.1.177 J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HEGKEINC_01850 2.6e-193 htrA 3.4.21.107 O Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain'
HEGKEINC_01851 8.5e-134 parB K Belongs to the ParB family
HEGKEINC_01852 1.1e-154 L Replication protein
HEGKEINC_01853 3.9e-136 3.1.21.3 V Type I restriction modification DNA specificity domain
HEGKEINC_01854 1.3e-51 L Helix-turn-helix domain
HEGKEINC_01855 1e-110 L PFAM Integrase catalytic region
HEGKEINC_01856 0.0 hsdR 3.1.21.3 V Subunit R is required for both nuclease and ATPase activities, but not for modification
HEGKEINC_01857 1.3e-298 hsdM 2.1.1.72 V HsdM N-terminal domain
HEGKEINC_01858 2.5e-90
HEGKEINC_01859 1.6e-18 L Integrase core domain
HEGKEINC_01860 1.3e-117 devA 3.6.3.25 V abc transporter atp-binding protein
HEGKEINC_01861 2.4e-163 hrtB V MacB-like periplasmic core domain

eggNOG-mapper v2 (Database: eggNOG v5.0, Jul. 2018 release)