ORF_ID e_value Gene_name EC_number CAZy COGs Description
APHEDCCB_00001 1.3e-257 dnaA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APHEDCCB_00002 6.3e-202 dnaN 2.7.7.7 L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
APHEDCCB_00003 1.1e-29 yyzM S Protein conserved in bacteria
APHEDCCB_00004 1.1e-203 ychF J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
APHEDCCB_00005 1.4e-104 pth 3.1.1.29 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
APHEDCCB_00006 0.0 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APHEDCCB_00007 1.7e-39 yabO J Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
APHEDCCB_00008 2.7e-61 divIC D Septum formation initiator
APHEDCCB_00010 1.3e-240 XK27_09285 3.5.2.6 V Beta-lactamase enzyme family
APHEDCCB_00011 5e-240 tilS 2.4.2.8, 6.3.4.19 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
APHEDCCB_00012 3.4e-97 hpt 2.4.2.8, 6.3.4.19 F Belongs to the purine pyrimidine phosphoribosyltransferase family
APHEDCCB_00013 0.0 ftsH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APHEDCCB_00014 1.3e-137 L Transposase
APHEDCCB_00019 5.3e-11
APHEDCCB_00028 5.5e-139 mreC M Involved in formation and maintenance of cell shape
APHEDCCB_00029 6.3e-88 mreD M Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
APHEDCCB_00030 1.7e-90 usp 3.5.1.28 CBM50 S CHAP domain
APHEDCCB_00031 1.2e-174 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APHEDCCB_00032 2.9e-218 araT 2.6.1.1 E Aminotransferase
APHEDCCB_00033 7e-144 recO L Involved in DNA repair and RecF pathway recombination
APHEDCCB_00034 9.6e-178 plsX 2.3.1.15 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
APHEDCCB_00035 9.3e-34 acpP1 IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
APHEDCCB_00036 9.9e-129 purC 4.1.1.21, 4.3.2.2, 6.3.2.6 F Belongs to the SAICAR synthetase family
APHEDCCB_00037 0.0 purL 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APHEDCCB_00038 2.9e-276 purF 2.4.2.14 F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
APHEDCCB_00039 4.8e-185 purM 6.3.3.1, 6.3.4.13 F Phosphoribosylformylglycinamidine cyclo-ligase
APHEDCCB_00040 1.4e-101 purN 2.1.2.2 F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
APHEDCCB_00041 6.6e-295 purH 2.1.2.3, 3.5.4.10 F Bifunctional purine biosynthesis protein PurH
APHEDCCB_00042 2.5e-89 L transposase activity
APHEDCCB_00043 3.5e-50 L transposition
APHEDCCB_00044 2e-32 L Integrase core domain protein
APHEDCCB_00045 2.3e-161 S CHAP domain
APHEDCCB_00046 3.4e-241 purD 6.3.4.13 F Belongs to the GARS family
APHEDCCB_00047 4.9e-76 purE 5.4.99.18 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
APHEDCCB_00048 2.2e-204 purK 6.3.4.18 F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
APHEDCCB_00049 2e-140 1.1.1.169 H Ketopantoate reductase
APHEDCCB_00050 8.7e-248 purB 4.3.2.2 F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APHEDCCB_00051 0.0 argS 6.1.1.19 J Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
APHEDCCB_00052 8.2e-70 argR K Regulates arginine biosynthesis genes
APHEDCCB_00053 1e-57 ymcA 3.6.3.21 S Belongs to the UPF0342 family
APHEDCCB_00054 0.0 mutS L that it carries out the mismatch recognition step. This protein has a weak ATPase activity
APHEDCCB_00055 7e-34 S Protein of unknown function (DUF3021)
APHEDCCB_00056 1.2e-61 KT phosphorelay signal transduction system
APHEDCCB_00058 0.0 mutL L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
APHEDCCB_00060 7.8e-103 ruvA 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
APHEDCCB_00061 7.1e-106 tag 3.2.2.20 L 3-methyladenine DNA glycosylase
APHEDCCB_00062 1e-232 cinA 3.5.1.42 S Belongs to the CinA family
APHEDCCB_00063 4.7e-205 recA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
APHEDCCB_00064 2.3e-66 spxA_2 1.20.4.1 P Belongs to the ArsC family
APHEDCCB_00066 1.9e-07
APHEDCCB_00071 0.0 polC 2.7.7.7 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APHEDCCB_00072 1.2e-235 pepS E COG2309 Leucyl aminopeptidase (aminopeptidase T)
APHEDCCB_00073 5.5e-36 XK27_02060 S Transglycosylase associated protein
APHEDCCB_00074 2.6e-55 badR K DNA-binding transcription factor activity
APHEDCCB_00075 3.5e-97 S reductase
APHEDCCB_00076 2.6e-88 L Integrase core domain protein
APHEDCCB_00077 3.2e-40 L transposition
APHEDCCB_00078 7.3e-22 yocD 3.4.17.13 V carboxypeptidase activity
APHEDCCB_00079 1.9e-86 yocD 3.4.17.13 V proteins, homologs of microcin C7 resistance protein MccF
APHEDCCB_00081 1.3e-137 rpsB J Belongs to the universal ribosomal protein uS2 family
APHEDCCB_00082 1.7e-182 tsf J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
APHEDCCB_00083 1.1e-83 S Putative small multi-drug export protein
APHEDCCB_00084 6.2e-76 ctsR K Belongs to the CtsR family
APHEDCCB_00085 0.0 clpC O Belongs to the ClpA ClpB family
APHEDCCB_00086 7e-127 dacA 3.4.16.4 M Belongs to the peptidase S11 family
APHEDCCB_00087 1.8e-32 dacA 3.4.16.4 M Belongs to the peptidase S11 family
APHEDCCB_00088 1.6e-230 dacA 3.4.16.4 M Belongs to the peptidase S11 family
APHEDCCB_00089 0.0 pnp 2.7.7.8 J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
APHEDCCB_00090 6.9e-144 S SseB protein N-terminal domain
APHEDCCB_00091 1.1e-112 cysE 2.3.1.30 E serine acetyltransferase
APHEDCCB_00092 1.5e-258 cysS 6.1.1.16, 6.3.1.13 J Belongs to the class-I aminoacyl-tRNA synthetase family
APHEDCCB_00093 4.2e-68 mrnC J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
APHEDCCB_00096 5.7e-135 trmH 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APHEDCCB_00097 3.5e-91 yacP S RNA-binding protein containing a PIN domain
APHEDCCB_00098 1.7e-154 degV S DegV family
APHEDCCB_00099 1.8e-31 K helix-turn-helix
APHEDCCB_00100 1.6e-182 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
APHEDCCB_00101 2e-79 rplM J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
APHEDCCB_00102 9.5e-65 rpsI J Belongs to the universal ribosomal protein uS9 family
APHEDCCB_00103 1.5e-35 K sequence-specific DNA binding
APHEDCCB_00105 0.0 S Lantibiotic dehydratase, C terminus
APHEDCCB_00106 2.4e-231 spaC2 V Lanthionine synthetase C family protein
APHEDCCB_00107 5.6e-183 EGP Major facilitator Superfamily
APHEDCCB_00108 5.9e-24 3.6.4.12
APHEDCCB_00109 5.9e-91 3.6.4.12 K Divergent AAA domain protein
APHEDCCB_00110 2.2e-224 int L Belongs to the 'phage' integrase family
APHEDCCB_00111 1.8e-38 S Helix-turn-helix domain
APHEDCCB_00112 4.9e-173
APHEDCCB_00114 3.4e-75 isp2 S pathogenesis
APHEDCCB_00115 5.7e-91 tnp L Transposase
APHEDCCB_00116 3.3e-225 capA M Bacterial capsule synthesis protein
APHEDCCB_00117 3.6e-39 gcvR T UPF0237 protein
APHEDCCB_00118 1.9e-242 XK27_08635 S UPF0210 protein
APHEDCCB_00119 8.3e-38 ais G alpha-ribazole phosphatase activity
APHEDCCB_00120 1.6e-143 vanY 3.4.17.14 M D-alanyl-D-alanine carboxypeptidase
APHEDCCB_00121 1.3e-102 acmA 3.2.1.17 NU amidase activity
APHEDCCB_00122 5.3e-198 hrcA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
APHEDCCB_00123 1.3e-71 grpE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
APHEDCCB_00124 7.5e-298 dnaK O Heat shock 70 kDa protein
APHEDCCB_00125 4.2e-190 dnaJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
APHEDCCB_00126 2.5e-138 truA 5.4.99.12 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
APHEDCCB_00127 6.2e-137 thiD 2.7.1.35, 2.7.1.49, 2.7.4.7 H phosphomethylpyrimidine kinase
APHEDCCB_00128 1.7e-60 hmpT S membrane
APHEDCCB_00130 0.0 amiA E ABC transporter, substrate-binding protein, family 5
APHEDCCB_00131 2.5e-169 L Transposase
APHEDCCB_00132 1.8e-56 amd 3.5.1.47 E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
APHEDCCB_00133 1.5e-233 cfa 2.1.1.317, 2.1.1.79 M cyclopropane-fatty-acyl-phospholipid synthase
APHEDCCB_00134 1.6e-77 sigH K DNA-templated transcription, initiation
APHEDCCB_00135 3e-148 ykuT M mechanosensitive ion channel
APHEDCCB_00136 6.4e-219 tig D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
APHEDCCB_00137 4.8e-73 rpoE K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
APHEDCCB_00138 7.6e-310 pyrG 6.3.4.2 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
APHEDCCB_00139 1.3e-84 XK27_03960 S Protein of unknown function (DUF3013)
APHEDCCB_00140 3.7e-81 mutT3 3.6.1.13, 3.6.1.55 L NUDIX domain
APHEDCCB_00141 3.7e-179 prmA J Ribosomal protein L11 methyltransferase
APHEDCCB_00142 1.3e-134 rsmE 2.1.1.193 J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
APHEDCCB_00143 0.0 cpdB 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
APHEDCCB_00144 2.4e-83 nrdI F Belongs to the NrdI family
APHEDCCB_00145 0.0 relA 2.7.6.5 KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APHEDCCB_00146 7.4e-74 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
APHEDCCB_00147 1.4e-09 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
APHEDCCB_00148 2e-27 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
APHEDCCB_00149 5.6e-59 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
APHEDCCB_00150 1.5e-45 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
APHEDCCB_00151 1.7e-237 ilvA 4.3.1.19 E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APHEDCCB_00152 3.3e-112 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
APHEDCCB_00153 1.1e-113 fnr5 K Catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
APHEDCCB_00154 9.3e-201 yhjX P Major Facilitator
APHEDCCB_00155 9.2e-43 rpsO J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
APHEDCCB_00156 5e-94 V VanZ like family
APHEDCCB_00158 1e-123 glnQ E abc transporter atp-binding protein
APHEDCCB_00159 5.8e-275 glnP P ABC transporter
APHEDCCB_00160 9.1e-153 uppP 3.6.1.27 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
APHEDCCB_00161 5.7e-135 mecA NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
APHEDCCB_00162 1.9e-185 tagO 2.7.8.33, 2.7.8.35 M transferase
APHEDCCB_00163 9.5e-144 sufC O ABC-type transport system involved in Fe-S cluster assembly, ATPase component
APHEDCCB_00164 1.4e-234 sufD O assembly protein SufD
APHEDCCB_00165 7.7e-238 sufS 2.8.1.7, 4.4.1.16 E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APHEDCCB_00166 2.5e-74 nifU C SUF system FeS assembly protein, NifU family
APHEDCCB_00167 6.5e-273 sufB O assembly protein SufB
APHEDCCB_00168 7e-10 oppA E ABC transporter substrate-binding protein
APHEDCCB_00169 2e-138 oppA E ABC transporter substrate-binding protein
APHEDCCB_00170 4.2e-27 oppB P ABC-type dipeptide oligopeptide nickel transport systems, permease components
APHEDCCB_00171 6.6e-11 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
APHEDCCB_00172 1.7e-33 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
APHEDCCB_00173 1.4e-38 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
APHEDCCB_00174 3e-27 oppD P Belongs to the ABC transporter superfamily
APHEDCCB_00175 2.5e-32 oppD P Belongs to the ABC transporter superfamily
APHEDCCB_00176 1.2e-62 oppD P Belongs to the ABC transporter superfamily
APHEDCCB_00177 3.1e-43 oppD P Belongs to the ABC transporter superfamily
APHEDCCB_00178 2.4e-60 oppF P Belongs to the ABC transporter superfamily
APHEDCCB_00179 3.4e-62 oppF P Belongs to the ABC transporter superfamily
APHEDCCB_00180 8.3e-23
APHEDCCB_00181 2.1e-157 hslO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
APHEDCCB_00182 7.4e-183 dus J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APHEDCCB_00183 1.9e-223 EGP Major facilitator Superfamily
APHEDCCB_00184 3.1e-72 adcR K transcriptional
APHEDCCB_00185 2.2e-136 adcC P ABC transporter, ATP-binding protein
APHEDCCB_00186 1.6e-127 adcB P ABC transporter (Permease
APHEDCCB_00187 1.4e-162 mleP2 S Transporter, auxin efflux carrier (AEC) family protein
APHEDCCB_00188 5.6e-65 ptsG 2.7.1.199, 2.7.1.208 G pts system
APHEDCCB_00189 2.1e-150 ptsG 2.7.1.199, 2.7.1.208, 2.7.1.211 G pts system
APHEDCCB_00190 2.5e-107 ptsG 2.7.1.199, 2.7.1.208, 2.7.1.211 G phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1
APHEDCCB_00191 6.8e-158 rgfB 3.1.3.90 L Endonuclease/Exonuclease/phosphatase family
APHEDCCB_00192 2.8e-257 pgi 5.3.1.9 G Belongs to the GPI family
APHEDCCB_00193 1.9e-127 yeeN K transcriptional regulatory protein
APHEDCCB_00194 9.8e-50 yajC U protein transport
APHEDCCB_00195 5.3e-141 uppS 2.5.1.31 H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APHEDCCB_00196 4.2e-144 cdsA 2.7.7.41 S Belongs to the CDS family
APHEDCCB_00197 1.4e-231 rseP 3.4.21.107, 3.4.21.116 M zinc metalloprotease
APHEDCCB_00198 0.0 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
APHEDCCB_00199 0.0 WQ51_06230 S ABC transporter substrate binding protein
APHEDCCB_00200 5.2e-142 cmpC S abc transporter atp-binding protein
APHEDCCB_00201 3.2e-41 groS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
APHEDCCB_00202 2e-286 groL O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
APHEDCCB_00203 4.4e-37 L Transposase
APHEDCCB_00204 6.4e-18 L transposase activity
APHEDCCB_00205 1.5e-30 L transposition
APHEDCCB_00208 4e-42
APHEDCCB_00209 6.8e-56 S TM2 domain
APHEDCCB_00210 1.2e-165 rluA 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
APHEDCCB_00211 0.0 pbp2A 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
APHEDCCB_00212 5.7e-25 secE U Belongs to the SecE SEC61-gamma family
APHEDCCB_00213 8.4e-96 nusG K Participates in transcription elongation, termination and antitermination
APHEDCCB_00214 4.6e-85 3.1.3.27, 3.1.3.4, 3.1.3.81, 3.6.1.27 I phosphatidate phosphatase activity
APHEDCCB_00215 6e-55 cof Q phosphatase activity
APHEDCCB_00216 6.2e-35 cof Q phosphatase activity
APHEDCCB_00217 1.6e-137 glcR K transcriptional regulator (DeoR family)
APHEDCCB_00218 0.0 leuS 6.1.1.4 J Belongs to the class-I aminoacyl-tRNA synthetase family
APHEDCCB_00219 3.8e-40 K transcriptional
APHEDCCB_00221 2.6e-76 S thiolester hydrolase activity
APHEDCCB_00222 1e-139 S COG1073 Hydrolases of the alpha beta superfamily
APHEDCCB_00223 5.7e-280 pncB 6.3.4.21 H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
APHEDCCB_00224 2.1e-151 nadE 6.3.1.5 H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
APHEDCCB_00225 1.9e-77 yhaI L Membrane
APHEDCCB_00226 5.1e-259 pepC 3.4.22.40 E aminopeptidase
APHEDCCB_00227 0.0 ponA 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
APHEDCCB_00228 2.4e-107 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
APHEDCCB_00229 4.9e-93 ypsA S Belongs to the UPF0398 family
APHEDCCB_00230 5.1e-51 gpsB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
APHEDCCB_00231 1.5e-222 rlmL 2.1.1.173, 2.1.1.264 L Belongs to the methyltransferase superfamily
APHEDCCB_00232 2.1e-295 mapZ D Early cell division protein that marks the future cell division site and supports proper FtsZ ring positioning
APHEDCCB_00233 0.0 snf 2.7.11.1 L Superfamily II DNA RNA helicases, SNF2 family'
APHEDCCB_00234 2.5e-23
APHEDCCB_00235 2.6e-255 mpl 6.3.2.4, 6.3.2.45, 6.3.2.8 M Belongs to the MurCDEF family
APHEDCCB_00236 7.3e-80 XK27_09675 K -acetyltransferase
APHEDCCB_00237 0.0 mltG ADL Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
APHEDCCB_00238 1.6e-77 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
APHEDCCB_00239 5.2e-59 L Integrase core domain protein
APHEDCCB_00240 2.9e-165 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
APHEDCCB_00241 7e-46 acyP 3.6.1.7 C Belongs to the acylphosphatase family
APHEDCCB_00242 6.4e-131 spoU 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APHEDCCB_00243 4.7e-93 XK27_09705 6.1.1.14 S HD superfamily hydrolase
APHEDCCB_00244 1.5e-97 ybhL S Belongs to the BI1 family
APHEDCCB_00247 1.1e-242 lysA 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
APHEDCCB_00248 5.8e-89 K transcriptional regulator
APHEDCCB_00249 7.6e-36 yneF S UPF0154 protein
APHEDCCB_00250 3.8e-148 murI 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
APHEDCCB_00251 7.1e-186 rdgB 3.6.1.66, 5.1.1.3 F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APHEDCCB_00252 3.5e-99 XK27_09740 S Phosphoesterase
APHEDCCB_00253 7.8e-85 ykuL S CBS domain
APHEDCCB_00254 4.5e-135 xerD L tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site
APHEDCCB_00255 3.8e-120 scpA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
APHEDCCB_00256 3e-99 scpB D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
APHEDCCB_00257 6.1e-140 rluB 5.4.99.19, 5.4.99.21, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
APHEDCCB_00258 1.2e-39 yidD S Could be involved in insertion of integral membrane proteins into the membrane
APHEDCCB_00259 1.2e-258 trkH P Cation transport protein
APHEDCCB_00260 1.5e-247 trkA P Potassium transporter peripheral membrane component
APHEDCCB_00261 7.9e-96 trmL 2.1.1.207 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
APHEDCCB_00262 2.1e-89 ribU U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
APHEDCCB_00263 3.1e-113 bcrC 3.6.1.27 I Membrane-associated phospholipid phosphatase
APHEDCCB_00264 5.6e-161 K sequence-specific DNA binding
APHEDCCB_00265 1.2e-32 V protein secretion by the type I secretion system
APHEDCCB_00266 7.4e-36 V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
APHEDCCB_00267 4.3e-57 V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
APHEDCCB_00268 1.8e-27 comA V protein secretion by the type I secretion system
APHEDCCB_00269 6.4e-67 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
APHEDCCB_00270 3.7e-22 yhaI L Membrane
APHEDCCB_00271 1.4e-54 S Domain of unknown function (DUF4173)
APHEDCCB_00272 6.8e-95 ureI S AmiS/UreI family transporter
APHEDCCB_00273 7.6e-46 ureA 3.5.1.5 E Belongs to the urease gamma subunit family
APHEDCCB_00274 7.8e-54 ureB 3.5.1.5 E Belongs to the urease beta subunit family
APHEDCCB_00275 0.0 ureC 3.5.1.5 E Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family
APHEDCCB_00276 6.6e-78 ureE O enzyme active site formation
APHEDCCB_00277 5.3e-130 ureF O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
APHEDCCB_00278 9.5e-112 ureG KO Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
APHEDCCB_00279 2.2e-159 ureD O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
APHEDCCB_00280 2.7e-177 cbiM P PDGLE domain
APHEDCCB_00281 1.7e-137 P cobalt transport protein
APHEDCCB_00282 1.6e-131 cbiO P ABC transporter
APHEDCCB_00283 3.3e-105 ET amino acid transport
APHEDCCB_00284 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
APHEDCCB_00285 0.0 3.3.1.1, 3.6.1.55, 3.6.1.67 F NUDIX domain
APHEDCCB_00286 3.8e-205 EGP Transmembrane secretion effector
APHEDCCB_00287 1.8e-153 ET amino acid transport
APHEDCCB_00288 7.1e-164 metQ M Belongs to the NlpA lipoprotein family
APHEDCCB_00289 7.1e-86 dapE 3.5.1.18 E COG0624, acetylornithine deacetylase succinyl-diaminopimelate desuccinylase and related deacylases
APHEDCCB_00290 1.2e-61 dapE 3.5.1.18 E succinyl-diaminopimelate desuccinylase activity
APHEDCCB_00291 1.4e-62 dapE 3.5.1.18 E succinyl-diaminopimelate desuccinylase activity
APHEDCCB_00292 1.2e-189 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APHEDCCB_00293 5.2e-98 metI P ABC transporter (Permease
APHEDCCB_00294 4.6e-211 sstT E Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
APHEDCCB_00295 5.5e-158 salL 2.5.1.63, 2.5.1.94 S S-adenosyl-l-methionine hydroxide adenosyltransferase
APHEDCCB_00296 9.4e-95 S UPF0397 protein
APHEDCCB_00297 0.0 ykoD P abc transporter atp-binding protein
APHEDCCB_00298 1.2e-149 cbiQ P cobalt transport
APHEDCCB_00299 0.0 tkt 2.2.1.1 G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
APHEDCCB_00300 6.9e-11 ulaG S L-ascorbate 6-phosphate lactonase
APHEDCCB_00301 1.4e-121 ktrA P COG0569 K transport systems, NAD-binding component
APHEDCCB_00302 2.1e-244 P COG0168 Trk-type K transport systems, membrane components
APHEDCCB_00303 1.1e-130 rsmG 2.1.1.170 J Ribosomal RNA small subunit methyltransferase G
APHEDCCB_00304 4e-90 yceD K metal-binding, possibly nucleic acid-binding protein
APHEDCCB_00305 3e-122 T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
APHEDCCB_00306 2.8e-282 T PhoQ Sensor
APHEDCCB_00307 4.7e-82 nrdR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APHEDCCB_00308 6.5e-218 dnaB L Replication initiation and membrane attachment
APHEDCCB_00309 4.4e-166 dnaI L Primosomal protein DnaI
APHEDCCB_00310 2e-247 der 1.1.1.399, 1.1.1.95 S GTPase that plays an essential role in the late steps of ribosome biogenesis
APHEDCCB_00312 1.2e-34
APHEDCCB_00313 6.7e-14 yrdC 3.5.1.19 Q isochorismatase
APHEDCCB_00314 3e-27 L Integrase core domain protein
APHEDCCB_00315 1.9e-46 L transposase activity
APHEDCCB_00316 3.2e-42 L Transposase
APHEDCCB_00317 2e-222 pgk 2.7.2.3, 5.3.1.1 F Belongs to the phosphoglycerate kinase family
APHEDCCB_00318 7.8e-28 L transposase activity
APHEDCCB_00319 8.6e-232 serS 6.1.1.11 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
APHEDCCB_00320 4.2e-62 manO S protein conserved in bacteria
APHEDCCB_00321 6.2e-168 manN G PTS system mannose fructose sorbose family IID component
APHEDCCB_00322 1.7e-116 manM G pts system
APHEDCCB_00323 1.1e-181 manL 2.7.1.191 G pts system
APHEDCCB_00324 1.5e-140 XK27_00940 1.2.1.70, 3.5.1.9 S Metal-dependent hydrolase
APHEDCCB_00325 1e-153 yitU 3.1.3.104 S hydrolases of the HAD superfamily
APHEDCCB_00326 1.9e-248 pbuO S permease
APHEDCCB_00327 1.4e-77 ydiB 2.7.1.221, 5.1.1.1 M ATPase or kinase
APHEDCCB_00328 2.4e-92 XK27_05885 2.3.1.82 M Acetyltransferase GNAT Family
APHEDCCB_00329 2.5e-220 brpA K Transcriptional
APHEDCCB_00330 3.9e-81 rimP S Required for maturation of 30S ribosomal subunits
APHEDCCB_00331 3.1e-212 nusA K Participates in both transcription termination and antitermination
APHEDCCB_00332 1e-47 ylxR K Nucleic-acid-binding protein implicated in transcription termination
APHEDCCB_00333 1.4e-41 ylxQ J ribosomal protein
APHEDCCB_00334 0.0 infB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
APHEDCCB_00335 1.7e-57 rbfA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
APHEDCCB_00336 2e-22 yvdD 3.2.2.10 S Belongs to the LOG family
APHEDCCB_00337 1.4e-48 yvdD 3.2.2.10 L Belongs to the LOG family
APHEDCCB_00338 1.4e-223 femA 2.3.2.10, 2.3.2.16, 2.3.2.17, 2.3.2.18 V protein involved in methicillin resistance
APHEDCCB_00339 1.4e-275 murE 6.3.2.13, 6.3.2.7 M to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APHEDCCB_00340 3.8e-282 ytgP S Membrane protein involved in the export of O-antigen and teichoic acid
APHEDCCB_00341 9.5e-96 pacL 3.6.3.8, 3.6.3.9 P cation transport ATPase
APHEDCCB_00342 4.7e-202 metB 2.5.1.48, 4.4.1.8 E cystathionine
APHEDCCB_00343 1.1e-222 malY 4.4.1.8 E COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
APHEDCCB_00345 1.2e-08 sacB 2.4.1.10, 2.4.1.9, 3.2.1.26 GH32,GH68 G Belongs to the glycosyl hydrolase 68 family
APHEDCCB_00346 4.4e-112 upp 2.4.2.9 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
APHEDCCB_00347 1.8e-104 clpP 3.4.21.92 OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
APHEDCCB_00348 1.2e-74 ylbF S Belongs to the UPF0342 family
APHEDCCB_00349 7.1e-46 ylbG S UPF0298 protein
APHEDCCB_00350 3.8e-210 livJ E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component
APHEDCCB_00351 1.9e-145 livH E Belongs to the binding-protein-dependent transport system permease family
APHEDCCB_00352 1.4e-138 livM E Belongs to the binding-protein-dependent transport system permease family
APHEDCCB_00353 9.6e-138 livG E COG0411 ABC-type branched-chain amino acid transport systems, ATPase component
APHEDCCB_00354 4.8e-123 livF E COG0410 ABC-type branched-chain amino acid transport systems, ATPase component
APHEDCCB_00355 3.4e-68 acuB S IMP dehydrogenase activity
APHEDCCB_00356 8.9e-41 acuB S IMP dehydrogenase activity
APHEDCCB_00357 2.2e-168 cysK 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
APHEDCCB_00358 1.1e-110 yvyE 3.4.13.9 S YigZ family
APHEDCCB_00359 4.5e-252 comFA L Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
APHEDCCB_00360 1.7e-122 comFC S Competence protein
APHEDCCB_00361 2.1e-94 hpf J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
APHEDCCB_00368 2.1e-166 ppaC 3.6.1.1 C inorganic pyrophosphatase
APHEDCCB_00369 6.4e-108 S Domain of unknown function (DUF1803)
APHEDCCB_00370 1.3e-101 ygaC J Belongs to the UPF0374 family
APHEDCCB_00371 1.2e-130 recX 2.4.1.337 GT4 S Regulatory protein RecX
APHEDCCB_00372 6.7e-259 rumA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APHEDCCB_00373 8e-193 asnA 6.3.1.1 E aspartate--ammonia ligase
APHEDCCB_00374 2.4e-256 lysC 2.7.2.4 E Belongs to the aspartokinase family
APHEDCCB_00375 1.9e-115 S Haloacid dehalogenase-like hydrolase
APHEDCCB_00376 2.4e-139 phaB 5.3.3.14, 5.3.3.18 I Belongs to the enoyl-CoA hydratase isomerase family
APHEDCCB_00377 4e-72 marR K Transcriptional regulator, MarR family
APHEDCCB_00378 2.3e-173 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APHEDCCB_00379 3.3e-30 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
APHEDCCB_00380 2.6e-172 fabK 1.3.1.9 S 2-Nitropropane dioxygenase
APHEDCCB_00381 8.5e-165 fabD 2.3.1.39 I Malonyl CoA-acyl carrier protein transacylase
APHEDCCB_00382 1.6e-126 IQ reductase
APHEDCCB_00383 2.6e-233 fabF 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
APHEDCCB_00384 7.7e-56 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
APHEDCCB_00385 1.5e-71 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
APHEDCCB_00386 1.7e-257 accC 6.3.4.14, 6.4.1.2 I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
APHEDCCB_00387 1.6e-160 accD 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
APHEDCCB_00388 1.1e-138 accA 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
APHEDCCB_00389 4.7e-90 luxS 4.4.1.21 H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
APHEDCCB_00390 5.2e-65 tnp L Transposase
APHEDCCB_00391 8.1e-203 rny D Endoribonuclease that initiates mRNA decay
APHEDCCB_00392 1.8e-84 L Transposase
APHEDCCB_00393 5.6e-114 fruR K transcriptional
APHEDCCB_00394 5.5e-164 pfkB 2.7.1.11, 2.7.1.56 H Belongs to the carbohydrate kinase PfkB family. LacC subfamily
APHEDCCB_00395 2.6e-113 fruA 2.7.1.202 GT PTS system, Lactose/Cellobiose specific IIB subunit
APHEDCCB_00396 4.9e-208 fruA 2.7.1.202 G phosphotransferase system
APHEDCCB_00397 2.7e-260 gor 1.8.1.7 C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APHEDCCB_00398 4e-242 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
APHEDCCB_00400 6.8e-212 iscS2 2.8.1.7 E Cysteine sulfinate desulfinase cysteine desulfurase and related enzymes
APHEDCCB_00401 6.5e-229 thiI 2.8.1.4 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APHEDCCB_00402 1.4e-294 gtf1 2.4.1.52 GT4 M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
APHEDCCB_00403 9.4e-258 gtf2 M A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1
APHEDCCB_00404 2.9e-26 2.3.1.128 K acetyltransferase
APHEDCCB_00405 1.7e-48 rplU J This protein binds to 23S rRNA in the presence of protein L20
APHEDCCB_00406 1.5e-46 rpmA J Belongs to the bacterial ribosomal protein bL27 family
APHEDCCB_00407 7e-127 ydaF_2 J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APHEDCCB_00408 2.6e-64 WQ51_03320 S cog cog4835
APHEDCCB_00409 6.4e-61 XK27_08360 S EDD domain protein, DegV family
APHEDCCB_00410 5.5e-75 XK27_08360 S EDD domain protein, DegV family
APHEDCCB_00411 5.1e-139 dapB 1.17.1.8 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
APHEDCCB_00412 1.9e-225 cca 2.7.7.19, 2.7.7.72 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
APHEDCCB_00413 0.0 yfmR S abc transporter atp-binding protein
APHEDCCB_00414 1.6e-24 U response to pH
APHEDCCB_00415 2.1e-137 3.6.1.13, 3.6.1.55 F AdP-ribose pyrophosphatase
APHEDCCB_00416 3.8e-212 nadD 2.7.1.22, 2.7.7.1, 2.7.7.18, 3.6.1.55 H adenylyltransferase
APHEDCCB_00417 1.8e-256 gdhA 1.4.1.4 E Belongs to the Glu Leu Phe Val dehydrogenases family
APHEDCCB_00418 1e-69 def_1 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins
APHEDCCB_00419 1.9e-77 K DNA-binding transcription factor activity
APHEDCCB_00420 0.0 lmrA1 V abc transporter atp-binding protein
APHEDCCB_00421 0.0 lmrA2 V abc transporter atp-binding protein
APHEDCCB_00422 5.4e-45 K Acetyltransferase (GNAT) family
APHEDCCB_00423 3.2e-78 sptS 2.7.13.3 T Histidine kinase
APHEDCCB_00424 4.9e-131 pyrH 2.7.4.22 F Catalyzes the reversible phosphorylation of UMP to UDP
APHEDCCB_00425 1.3e-91 frr J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
APHEDCCB_00426 5.3e-161 cvfB S Protein conserved in bacteria
APHEDCCB_00427 7.4e-35 yozE S Belongs to the UPF0346 family
APHEDCCB_00428 2.9e-124 usp 3.5.1.104, 3.5.1.28 CBM50 S pathogenesis
APHEDCCB_00429 2.3e-61 rlpA M LysM domain protein
APHEDCCB_00430 8e-191 phoH T phosphate starvation-inducible protein PhoH
APHEDCCB_00434 0.0 metG 6.1.1.10, 6.1.1.20 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APHEDCCB_00435 1.8e-164 K transcriptional regulator (lysR family)
APHEDCCB_00436 1.4e-186 coiA 3.6.4.12 S Competence protein
APHEDCCB_00437 0.0 pepF E oligoendopeptidase F
APHEDCCB_00438 1.4e-127 yrrM 2.1.1.104 S O-Methyltransferase
APHEDCCB_00439 4.5e-176 prsA 3.1.3.16, 5.2.1.8 O peptidyl-prolyl cis-trans isomerase activity
APHEDCCB_00440 0.0 alaS 6.1.1.7 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APHEDCCB_00441 7.9e-24 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
APHEDCCB_00442 1.5e-152 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
APHEDCCB_00443 2.3e-103 3.4.17.14, 3.5.1.28 NU amidase activity
APHEDCCB_00444 4.9e-145 cnhA 3.5.1.3 S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
APHEDCCB_00445 1e-226 mtnE 2.6.1.83 E mutations do not affect methionine salvage in vivo however
APHEDCCB_00446 1.3e-190 argC 1.2.1.38 E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APHEDCCB_00447 1.5e-222 argJ 2.3.1.1, 2.3.1.35, 2.7.2.8 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
APHEDCCB_00448 7.9e-129 argB 2.7.2.8 E Belongs to the acetylglutamate kinase family. ArgB subfamily
APHEDCCB_00449 1.6e-210 argD 2.6.1.11, 2.6.1.17 E acetylornithine aminotransferase
APHEDCCB_00450 2.2e-130 yxkH G deacetylase
APHEDCCB_00451 2.3e-237 hom 1.1.1.3, 2.7.2.4 E homoserine dehydrogenase
APHEDCCB_00452 2.8e-154 thrB 2.7.1.39 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
APHEDCCB_00453 5.5e-153 rarD S Transporter
APHEDCCB_00454 2.2e-15 T peptidase
APHEDCCB_00455 8.9e-14 coiA 3.6.4.12 S Competence protein
APHEDCCB_00456 4.1e-112 S COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APHEDCCB_00457 1.9e-46 2.3.1.128, 5.2.1.8 J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APHEDCCB_00458 0.0 valS 6.1.1.9 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
APHEDCCB_00459 3.2e-16 atpE C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APHEDCCB_00460 4.3e-124 atpB C it plays a direct role in the translocation of protons across the membrane
APHEDCCB_00461 3.3e-78 atpF C ATP synthase F(0) sector subunit b
APHEDCCB_00462 9.3e-87 atpH C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APHEDCCB_00463 3.8e-279 atpA 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
APHEDCCB_00464 2.5e-158 atpG C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
APHEDCCB_00465 2.7e-263 atpD 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
APHEDCCB_00466 5.2e-67 atpC C Produces ATP from ADP in the presence of a proton gradient across the membrane
APHEDCCB_00467 2.8e-230 ftsW D Belongs to the SEDS family
APHEDCCB_00468 9.5e-225 tuf J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APHEDCCB_00469 1.4e-136 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
APHEDCCB_00470 2.8e-111 tmk 2.7.4.9 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APHEDCCB_00471 5.4e-161 holB 2.7.7.7 L dna polymerase iii
APHEDCCB_00472 3.1e-134 yaaT S stage 0 sporulation protein
APHEDCCB_00473 9.5e-55 yabA L Involved in initiation control of chromosome replication
APHEDCCB_00474 3.9e-159 rsmI 2.1.1.198 H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
APHEDCCB_00475 5.8e-225 amt P Ammonium Transporter
APHEDCCB_00476 1.8e-51 glnB K Belongs to the P(II) protein family
APHEDCCB_00477 6e-104 mur1 NU mannosyl-glycoprotein
APHEDCCB_00478 5.8e-149 XK27_04800 S Sucrose-6F-phosphate phosphohydrolase
APHEDCCB_00479 2.9e-68 nptA P sodium-dependent phosphate transmembrane transporter activity
APHEDCCB_00480 3.6e-221 nagA 3.5.1.25 G Belongs to the metallo-dependent hydrolases superfamily. NagA family
APHEDCCB_00481 5.8e-52
APHEDCCB_00482 2.2e-25
APHEDCCB_00483 3.9e-60
APHEDCCB_00484 6.1e-63 S membrane
APHEDCCB_00485 4.8e-176 glyQ 6.1.1.14 J glycyl-tRNA synthetase alpha subunit
APHEDCCB_00486 0.0 glyS 6.1.1.14 J Glycyl-tRNA synthetase beta subunit
APHEDCCB_00487 4.5e-39 ynzC S UPF0291 protein
APHEDCCB_00488 1.8e-254 cycA E permease
APHEDCCB_00489 1.1e-09 uvrX 2.7.7.7 L ImpB mucB samB family
APHEDCCB_00490 9.8e-71 pts33BCA G pts system
APHEDCCB_00491 1.1e-76 pts33BCA G pts system
APHEDCCB_00492 5.5e-84 pts33BCA G pts system
APHEDCCB_00493 4.6e-140 ppiA 5.2.1.8 O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APHEDCCB_00494 4.2e-57 L Transposase
APHEDCCB_00499 1.4e-167 fhuR K transcriptional regulator (lysR family)
APHEDCCB_00500 1.5e-77 lspA 3.4.23.36 MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APHEDCCB_00501 8.5e-162 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
APHEDCCB_00502 3.7e-88 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
APHEDCCB_00503 4.9e-227 pyrP F uracil Permease
APHEDCCB_00504 1e-173 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
APHEDCCB_00505 1.1e-211 carA 6.3.5.5 F carbamoyl-phosphate synthetase glutamine chain
APHEDCCB_00506 0.0 carB 6.3.5.5 F carbamoyl-phosphate synthetase ammonia chain
APHEDCCB_00507 6.4e-134 2.1.1.223 S Putative SAM-dependent methyltransferase
APHEDCCB_00508 1.2e-21 acrA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APHEDCCB_00509 2.3e-34 V efflux transmembrane transporter activity
APHEDCCB_00510 2.6e-30 V efflux transmembrane transporter activity
APHEDCCB_00511 8.2e-28 ytrF V efflux transmembrane transporter activity
APHEDCCB_00512 8.2e-77 rplJ J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
APHEDCCB_00513 3e-52 rplL J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
APHEDCCB_00514 1.8e-63 L Transposase
APHEDCCB_00515 5.4e-14 M the current gene model (or a revised gene model) may contain a
APHEDCCB_00517 0.0 mdlB V abc transporter atp-binding protein
APHEDCCB_00518 0.0 lmrA V abc transporter atp-binding protein
APHEDCCB_00519 6e-199 queA 2.4.99.17 J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
APHEDCCB_00520 3.4e-121 nagB 3.1.1.31, 3.5.99.6 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
APHEDCCB_00521 3.6e-189 2.7.13.3 T signal transduction protein with a C-terminal ATPase domain
APHEDCCB_00522 2.5e-132 rr02 KT response regulator
APHEDCCB_00523 8.5e-173 2.7.7.73, 2.7.7.80 H Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
APHEDCCB_00524 2.1e-34 2.7.7.73, 2.7.7.80 H Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
APHEDCCB_00525 4.8e-168 V ABC transporter
APHEDCCB_00526 5.4e-122 sagI S ABC-2 type transporter
APHEDCCB_00527 6.9e-197 yceA S Belongs to the UPF0176 family
APHEDCCB_00528 2.3e-31 XK27_00085 K Transcriptional
APHEDCCB_00529 1.1e-22
APHEDCCB_00530 8.2e-145 deoD_1 2.4.2.3 F Phosphorylase superfamily
APHEDCCB_00531 2.1e-112 S VIT family
APHEDCCB_00532 2.2e-131 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
APHEDCCB_00533 4e-220 hipO 3.5.1.47 E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
APHEDCCB_00534 2.6e-17 ald 1.4.1.1 E alanine dehydrogenase activity
APHEDCCB_00535 6.5e-46 ald 1.4.1.1 C Belongs to the AlaDH PNT family
APHEDCCB_00536 4e-248 merA 1.16.1.1 C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APHEDCCB_00537 8.8e-104 GBS0088 J protein conserved in bacteria
APHEDCCB_00538 2.5e-142 mvk 1.1.1.88, 2.3.3.10, 2.7.1.36 I mevalonate kinase
APHEDCCB_00539 6e-174 mvaD 4.1.1.33 I diphosphomevalonate decarboxylase
APHEDCCB_00540 4.6e-180 mvaK2 2.7.1.36, 2.7.1.43, 2.7.4.2 I GHMP kinases N terminal domain
APHEDCCB_00541 8.9e-192 fni 1.1.1.88, 5.3.3.2 C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
APHEDCCB_00542 5.1e-254 glmU 2.3.1.157, 2.7.7.23 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
APHEDCCB_00543 1e-96 nudF 3.6.1.13 L AdP-ribose pyrophosphatase
APHEDCCB_00544 2.5e-21
APHEDCCB_00545 5.9e-118 mtnN 3.2.2.9 E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
APHEDCCB_00547 3.5e-07 U protein secretion
APHEDCCB_00548 2.1e-50 U protein secretion
APHEDCCB_00549 1.1e-11 U protein secretion
APHEDCCB_00550 1.4e-192 dgs 2.4.1.208 GT4 M Glycosyltransferase, group 1 family protein
APHEDCCB_00551 1.8e-248 mgs 2.4.1.337 GT4 M Glycosyltransferase, group 1 family protein
APHEDCCB_00552 4.9e-21 XK27_13030
APHEDCCB_00553 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
APHEDCCB_00554 9.9e-169 S hydrolases or acyltransferases (alpha beta hydrolase superfamily)
APHEDCCB_00555 9.8e-163 S Protein of unknown function (DUF3114)
APHEDCCB_00556 1.2e-22 S Protein of unknown function (DUF3114)
APHEDCCB_00557 1.5e-118 yqfA K protein, Hemolysin III
APHEDCCB_00558 1e-25 K hmm pf08876
APHEDCCB_00559 2.7e-233 mvaA 1.1.1.34, 1.1.1.88, 2.3.1.9 C Belongs to the HMG-CoA reductase family
APHEDCCB_00560 1.7e-218 mvaS 2.3.3.10 I synthase
APHEDCCB_00561 2.2e-167 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
APHEDCCB_00562 3.4e-91 folA 1.5.1.3, 1.5.1.47, 2.1.1.45, 3.5.4.12 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
APHEDCCB_00563 9.7e-22
APHEDCCB_00564 2e-225 clpX O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
APHEDCCB_00565 3e-110 engB D Necessary for normal cell division and for the maintenance of normal septation
APHEDCCB_00566 1.5e-250 mmuP E amino acid
APHEDCCB_00567 1.2e-177 mmuM 1.5.1.20, 2.1.1.10 H Homocysteine
APHEDCCB_00568 1.4e-29 S Domain of unknown function (DUF1912)
APHEDCCB_00569 4.9e-15 L Helix-hairpin-helix DNA-binding motif class 1
APHEDCCB_00570 7.1e-102 plsY 2.3.1.15, 3.5.1.104 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
APHEDCCB_00571 0.0 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
APHEDCCB_00572 0.0 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
APHEDCCB_00573 2.4e-200 ilvE 2.6.1.42 E Aminotransferase
APHEDCCB_00574 4.8e-16 S Protein of unknown function (DUF2969)
APHEDCCB_00577 8.4e-205 rpsA 1.17.7.4 J ribosomal protein S1
APHEDCCB_00580 5.9e-46 S Domain of Unknown Function with PDB structure (DUF3862)
APHEDCCB_00581 1.9e-27 S Domain of Unknown Function with PDB structure (DUF3862)
APHEDCCB_00582 6.1e-70 M Pfam SNARE associated Golgi protein
APHEDCCB_00583 3.4e-233 murN 2.3.2.10, 2.3.2.16 V FemAB family
APHEDCCB_00584 9.3e-59 S oxidoreductase
APHEDCCB_00585 9.7e-66 S oxidoreductase
APHEDCCB_00586 3.7e-48 XK27_09445 S Domain of unknown function (DUF1827)
APHEDCCB_00587 1.8e-86 mutT 3.5.4.33, 3.6.1.13, 3.6.1.55 L Belongs to the Nudix hydrolase family
APHEDCCB_00588 0.0 clpE O Belongs to the ClpA ClpB family
APHEDCCB_00589 1.4e-181 argF 2.1.3.3 E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APHEDCCB_00590 1.3e-34 ykuJ S protein conserved in bacteria
APHEDCCB_00591 7.5e-118 WQ51_01820 P Binding-protein-dependent transport system inner membrane component
APHEDCCB_00592 1.1e-130 glnQ 3.6.3.21 E abc transporter atp-binding protein
APHEDCCB_00593 1.1e-78 feoA P FeoA domain protein
APHEDCCB_00594 0.0 feoB P transporter of a GTP-driven Fe(2 ) uptake system
APHEDCCB_00595 1.5e-07
APHEDCCB_00596 2e-103 1.1.1.133, 5.1.3.13 M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
APHEDCCB_00597 2.2e-45 K sequence-specific DNA binding
APHEDCCB_00598 1.5e-35 yugF I carboxylic ester hydrolase activity
APHEDCCB_00599 7.5e-23 I Alpha/beta hydrolase family
APHEDCCB_00600 3.9e-156 folD 1.5.1.5, 3.5.4.9 F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
APHEDCCB_00601 8.6e-148 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
APHEDCCB_00602 0.0 pbp2b 3.4.16.4 M penicillin-binding protein
APHEDCCB_00603 4.9e-105 recR L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
APHEDCCB_00604 5.8e-64 licT K transcriptional antiterminator
APHEDCCB_00605 6.8e-53 licT K transcriptional antiterminator
APHEDCCB_00606 5.9e-88 ybeY 2.6.99.2, 3.5.4.5 S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
APHEDCCB_00607 1.7e-64 dgkA 2.7.1.107, 2.7.1.66 M Diacylglycerol kinase
APHEDCCB_00608 1.3e-165 era M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
APHEDCCB_00609 1.2e-154 fpg 3.2.2.23, 4.2.99.18 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
APHEDCCB_00610 1.1e-104 coaE 2.7.1.24, 3.2.2.23, 4.2.99.18 GH23 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
APHEDCCB_00611 6e-133 mdtG EGP Major facilitator Superfamily
APHEDCCB_00612 9.5e-74 mdtG EGP Major facilitator Superfamily
APHEDCCB_00613 2e-33 secG U Preprotein translocase subunit SecG
APHEDCCB_00614 0.0 rnr J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
APHEDCCB_00615 1.1e-80 smpB O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
APHEDCCB_00616 6.9e-275 ppiB 5.2.1.8 G PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APHEDCCB_00617 1.7e-63 yugI 5.3.1.9 J RNA binding protein, contains ribosomal protein S1 domain
APHEDCCB_00618 7.1e-211 pepQ 3.4.13.9 E Belongs to the peptidase M24B family
APHEDCCB_00619 4.4e-183 ccpA K Catabolite control protein A
APHEDCCB_00620 1e-27 yyaQ S YjbR
APHEDCCB_00621 6.6e-101 yyaQ V Protein conserved in bacteria
APHEDCCB_00622 1.3e-207 glxK 2.7.1.165 G Belongs to the glycerate kinase type-1 family
APHEDCCB_00623 1e-78 yueI S Protein of unknown function (DUF1694)
APHEDCCB_00624 9.6e-247 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
APHEDCCB_00625 2e-25 WQ51_00785
APHEDCCB_00626 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
APHEDCCB_00627 2e-219 ywbD 2.1.1.191 J Methyltransferase
APHEDCCB_00628 1.1e-121 aroD 1.1.1.25, 4.2.1.10 E Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
APHEDCCB_00629 6.3e-162 aroE 1.1.1.25 E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APHEDCCB_00630 7.7e-202 aroB 2.7.1.71, 4.2.3.4 E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APHEDCCB_00631 4.5e-219 aroC 4.2.3.5 E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
APHEDCCB_00632 2.2e-207 tyrA 1.3.1.12, 1.3.1.43 E prephenate dehydrogenase
APHEDCCB_00633 3.2e-53 yheA S Belongs to the UPF0342 family
APHEDCCB_00634 2.5e-172 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
APHEDCCB_00635 2.6e-236 aroA 1.3.1.12, 1.3.1.43, 2.5.1.19 E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
APHEDCCB_00636 2.5e-86 aroK 1.1.1.25, 2.7.1.71, 4.2.1.10, 4.2.3.4 F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APHEDCCB_00637 2.5e-152 pheA 4.2.1.51 E Prephenate dehydratase
APHEDCCB_00638 1.3e-241 msrR K Transcriptional regulator
APHEDCCB_00639 2.2e-149 ydiA P C4-dicarboxylate transporter malic acid transport protein
APHEDCCB_00640 2.4e-203 I acyl-CoA dehydrogenase
APHEDCCB_00641 3.2e-95 mip S hydroperoxide reductase activity
APHEDCCB_00642 1.3e-254 rumA 2.1.1.190 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APHEDCCB_00643 8.9e-20
APHEDCCB_00644 3.2e-46
APHEDCCB_00645 1e-31 K Cro/C1-type HTH DNA-binding domain
APHEDCCB_00646 1e-29 dam 2.1.1.72 L D12 class N6 adenine-specific DNA methyltransferase
APHEDCCB_00647 5.7e-34 estA E GDSL-like Lipase/Acylhydrolase
APHEDCCB_00648 1.6e-95
APHEDCCB_00649 1.4e-94 cas9 L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
APHEDCCB_00650 0.0 cas9 L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
APHEDCCB_00651 4.2e-172 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
APHEDCCB_00652 1.8e-53 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
APHEDCCB_00653 9e-195 S CRISPR-associated protein Csn2 subfamily St
APHEDCCB_00654 2.7e-146 ycgQ S TIGR03943 family
APHEDCCB_00655 1.2e-155 XK27_03015 S permease
APHEDCCB_00657 0.0 yhgF K Transcriptional accessory protein
APHEDCCB_00658 9.9e-42 pspC KT PspC domain
APHEDCCB_00659 6.8e-170 hprK F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
APHEDCCB_00660 4e-147 lgt 2.1.1.199 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
APHEDCCB_00662 5.5e-69 ytxH S General stress protein
APHEDCCB_00664 2e-177 yegQ O Peptidase U32
APHEDCCB_00665 3.4e-252 yegQ O Peptidase U32
APHEDCCB_00666 8.1e-46 S CHY zinc finger
APHEDCCB_00667 8.4e-88 bioY S biotin synthase
APHEDCCB_00669 1.1e-33 XK27_12190 S protein conserved in bacteria
APHEDCCB_00670 1.1e-234 mntH P H( )-stimulated, divalent metal cation uptake system
APHEDCCB_00671 4.3e-12
APHEDCCB_00672 6e-209 dcm 2.1.1.37 H C-5 cytosine-specific DNA methylase
APHEDCCB_00673 4.1e-225 mutH L DNA mismatch repair enzyme MutH
APHEDCCB_00674 4e-29 S SIR2-like domain
APHEDCCB_00675 2.1e-167 S SIR2-like domain
APHEDCCB_00676 9.4e-167 S Domain of unknown function DUF87
APHEDCCB_00677 8.6e-94 L Transposase
APHEDCCB_00679 8.2e-35
APHEDCCB_00680 9.2e-286 lysS 6.1.1.6 J Belongs to the class-II aminoacyl-tRNA synthetase family
APHEDCCB_00681 1.9e-15 M LysM domain
APHEDCCB_00682 2.4e-58 M LysM domain
APHEDCCB_00683 3.1e-20
APHEDCCB_00684 2.7e-171 S hydrolase
APHEDCCB_00685 9.6e-115 pgm6 5.4.2.11, 5.4.2.12 G Phosphoglycerate mutase
APHEDCCB_00686 7.9e-82 ybaK S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APHEDCCB_00687 4.5e-145 XK27_00880 3.5.1.28 M Glycosyl hydrolase, family 25
APHEDCCB_00688 2.1e-27 P Hemerythrin HHE cation binding domain protein
APHEDCCB_00689 1.4e-113 1.14.14.5 C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APHEDCCB_00690 1.7e-10 MA20_36090 S Protein of unknown function (DUF2974)
APHEDCCB_00691 2.3e-36 MA20_36090 S Protein of unknown function (DUF2974)
APHEDCCB_00692 2.3e-17 MA20_36090 S Protein of unknown function (DUF2974)
APHEDCCB_00693 1.7e-134 sdh 1.1.1.276, 1.1.1.313, 1.1.1.381 S Belongs to the short-chain dehydrogenases reductases (SDR) family
APHEDCCB_00694 0.0 hsdR 3.1.21.3 V Type I restriction enzyme R protein N terminus (HSDR_N)
APHEDCCB_00695 5.6e-289 hsdM 2.1.1.72 V N-6 DNA Methylase
APHEDCCB_00696 1e-146 hsdS 3.1.21.3 V Type I restriction modification DNA specificity domain protein
APHEDCCB_00697 9.5e-149 L Protein of unknown function (DUF2813)
APHEDCCB_00698 2.6e-92 pcrA1 3.6.4.12 L UvrD/REP helicase N-terminal domain
APHEDCCB_00699 1.4e-10 endA F DNA/RNA non-specific endonuclease
APHEDCCB_00700 1.2e-33
APHEDCCB_00701 1.1e-190 higA K Pfam:DUF955
APHEDCCB_00702 5.8e-167 spd F DNA RNA non-specific endonuclease
APHEDCCB_00703 1.5e-92 lemA S LemA family
APHEDCCB_00704 6.4e-133 htpX O Belongs to the peptidase M48B family
APHEDCCB_00705 4.2e-75 S Psort location CytoplasmicMembrane, score
APHEDCCB_00706 6.2e-56 S Domain of unknown function (DUF4430)
APHEDCCB_00707 0.0 ppc 4.1.1.31 H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
APHEDCCB_00708 1.2e-183 holA 2.7.7.7 L DNA polymerase III delta subunit
APHEDCCB_00709 8.5e-113 sodA 1.15.1.1 C radicals which are normally produced within the cells and which are toxic to biological systems
APHEDCCB_00710 1.9e-23 L Transposase
APHEDCCB_00711 2.2e-185 3.5.2.6 V D-alanyl-D-alanine carboxypeptidase
APHEDCCB_00712 4.4e-115 pilD 3.4.23.43 NOU Bacterial Peptidase A24 N-terminal domain
APHEDCCB_00713 3.2e-92 dps P Belongs to the Dps family
APHEDCCB_00714 5.8e-79 perR P Belongs to the Fur family
APHEDCCB_00715 8.4e-28 yqgQ S protein conserved in bacteria
APHEDCCB_00716 2.2e-179 glk 2.7.1.2 G Glucokinase
APHEDCCB_00717 0.0 typA T GTP-binding protein TypA
APHEDCCB_00719 1.6e-252 murD 6.3.2.9 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
APHEDCCB_00720 1e-201 murG 2.4.1.227 GT28 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
APHEDCCB_00721 5.7e-171 divIB D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
APHEDCCB_00722 8e-252 ftsA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
APHEDCCB_00723 5.4e-237 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
APHEDCCB_00724 2.3e-122 ylmE S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
APHEDCCB_00725 1.4e-96 sepF D cell septum assembly
APHEDCCB_00726 2.6e-34 yggT D integral membrane protein
APHEDCCB_00727 1.2e-143 ylmH T S4 RNA-binding domain
APHEDCCB_00728 1.8e-135 divIVA D Cell division protein DivIVA
APHEDCCB_00729 0.0 ileS 6.1.1.5 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
APHEDCCB_00730 7.9e-230 mntH P Mn2 and Fe2 transporters of the NRAMP family
APHEDCCB_00731 2e-45 rpmE2 J 50S ribosomal protein L31
APHEDCCB_00732 1.5e-177 apbE 2.7.1.180 H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
APHEDCCB_00733 1e-184 nrnA 3.1.13.3, 3.1.3.7 S domain protein
APHEDCCB_00734 1.2e-154 gst O Glutathione S-transferase
APHEDCCB_00735 1.6e-188 add 3.5.4.4 F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
APHEDCCB_00736 2.4e-112 tdk 2.7.1.21 F thymidine kinase
APHEDCCB_00737 6.6e-193 prfA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
APHEDCCB_00738 1.2e-154 prmB 2.1.1.297, 2.1.1.298 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
APHEDCCB_00739 9.7e-109 ywlC 2.7.7.87, 3.1.3.48 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
APHEDCCB_00740 1.8e-234 glyA 2.1.2.1 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
APHEDCCB_00741 1.2e-177 ndpA S 37-kD nucleoid-associated bacterial protein
APHEDCCB_00742 6.6e-105 pvaA M lytic transglycosylase activity
APHEDCCB_00743 0.0 yfiB1 V abc transporter atp-binding protein
APHEDCCB_00744 0.0 XK27_10035 V abc transporter atp-binding protein
APHEDCCB_00745 1.7e-09 S D-Ala-teichoic acid biosynthesis protein
APHEDCCB_00746 1.4e-297 dltA 6.1.1.13 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
APHEDCCB_00747 8.7e-237 dltB M Membrane protein involved in D-alanine export
APHEDCCB_00748 1.7e-35 dltC 6.1.1.13 IQ Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
APHEDCCB_00749 3.6e-230 dltD M Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
APHEDCCB_00750 1.2e-32 L Integrase core domain protein
APHEDCCB_00751 8.3e-18 L transposase activity
APHEDCCB_00752 0.0 3.6.3.8 P cation transport ATPase
APHEDCCB_00753 0.0 pabB 2.6.1.85, 4.1.3.27, 4.1.3.38 EH component I
APHEDCCB_00755 0.0 metE 2.1.1.14 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
APHEDCCB_00756 7.3e-166 metF 1.5.1.20 C reductase
APHEDCCB_00757 0.0 pgm 5.4.2.2, 5.4.2.8 G Phosphoglucomutase
APHEDCCB_00758 1.7e-94 panT S ECF transporter, substrate-specific component
APHEDCCB_00759 4.8e-94 coaBC 4.1.1.36, 6.3.2.5 H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APHEDCCB_00760 1.2e-120 coaB 4.1.1.36, 6.3.2.5 H Phosphopantothenate-cysteine ligase
APHEDCCB_00761 0.0 fhs 6.3.4.3 F Belongs to the formate--tetrahydrofolate ligase family
APHEDCCB_00762 6.4e-66 T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
APHEDCCB_00763 2.8e-40 T PhoQ Sensor
APHEDCCB_00764 2.2e-43 T PhoQ Sensor
APHEDCCB_00765 3.6e-88 T PhoQ Sensor
APHEDCCB_00766 2.1e-30 rpsT J rRNA binding
APHEDCCB_00767 1.9e-172 coaA 2.7.1.33 F Pantothenic acid kinase
APHEDCCB_00768 1.8e-107 rsmC 2.1.1.172 J Methyltransferase small domain protein
APHEDCCB_00769 1.2e-57 pdp 2.4.2.2, 2.4.2.4 F Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate
APHEDCCB_00770 1.3e-97 pdp 2.4.2.2, 2.4.2.4 F Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate
APHEDCCB_00771 1.4e-22 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
APHEDCCB_00772 4e-63 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
APHEDCCB_00773 1.3e-69 cdd 2.4.2.2, 3.5.4.5 F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
APHEDCCB_00774 9.5e-192 tcsA S ABC-type transport system, periplasmic component surface lipoprotein
APHEDCCB_00775 8.3e-282 xylG 3.6.3.17 S ABC transporter, ATP-binding protein
APHEDCCB_00776 3e-190 yufP S Belongs to the binding-protein-dependent transport system permease family
APHEDCCB_00777 4.8e-171 yufQ S Belongs to the binding-protein-dependent transport system permease family
APHEDCCB_00778 1.2e-120 ycbL 3.1.2.6 S COG0491 Zn-dependent hydrolases, including glyoxylases
APHEDCCB_00779 0.0 dinG 2.7.7.7, 3.6.4.12 L helicase involved in DNA repair and perhaps also replication
APHEDCCB_00780 3.1e-81 ypmB S Protein conserved in bacteria
APHEDCCB_00781 4.7e-216 aspB 2.6.1.1, 2.6.1.14 E Aminotransferase
APHEDCCB_00782 1.7e-262 asnS 6.1.1.22 J Catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
APHEDCCB_00783 1.5e-07
APHEDCCB_00784 3e-13
APHEDCCB_00785 3e-63 tdcF 3.5.99.10 J endoribonuclease L-PSP
APHEDCCB_00786 2e-123 queC 6.3.4.20 F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
APHEDCCB_00787 2.2e-81 queD 4.1.2.50, 4.2.3.12 H synthase
APHEDCCB_00788 2.5e-135 queE 1.97.1.4, 4.3.99.3 H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
APHEDCCB_00789 6.5e-95 queF 1.7.1.13 S Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily
APHEDCCB_00790 2.2e-19 D nuclear chromosome segregation
APHEDCCB_00791 2.8e-137 yejC S cyclic nucleotide-binding protein
APHEDCCB_00792 1.2e-163 rapZ S Displays ATPase and GTPase activities
APHEDCCB_00793 9.6e-183 ybhK S Required for morphogenesis under gluconeogenic growth conditions
APHEDCCB_00794 8.7e-162 whiA K May be required for sporulation
APHEDCCB_00795 8.2e-120 pepD E Dipeptidase
APHEDCCB_00796 5.8e-41 pepD E dipeptidase activity
APHEDCCB_00797 5.4e-32 cspD K Cold shock protein domain
APHEDCCB_00798 0.0 copB 3.6.3.4 P P-type ATPase
APHEDCCB_00799 1.5e-194 3.1.21.3 L Subunit R is required for both nuclease and ATPase activities, but not for modification
APHEDCCB_00800 3.9e-170 mccA 2.5.1.134, 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
APHEDCCB_00801 2.7e-219 metC 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
APHEDCCB_00802 1.5e-95 cysE 2.3.1.30 E Bacterial transferase hexapeptide (six repeats)
APHEDCCB_00803 3.7e-54 hsdS 2.1.1.72, 3.1.21.3 V type I restriction modification DNA specificity domain
APHEDCCB_00804 1.7e-111 hsdM 2.1.1.72 V type I restriction-modification system
APHEDCCB_00805 3.7e-157 glcU U Glucose uptake
APHEDCCB_00806 1.8e-08 4.2.1.53 S Myosin-crossreactive antigen
APHEDCCB_00807 2.2e-78 hsdM 2.1.1.72 V HsdM N-terminal domain
APHEDCCB_00808 2.2e-101 XK27_10720 D peptidase activity
APHEDCCB_00809 1.1e-292 adcA P Belongs to the bacterial solute-binding protein 9 family
APHEDCCB_00810 2.2e-08
APHEDCCB_00811 1.2e-172 yeiH S Membrane
APHEDCCB_00812 5.5e-119 mur1 NU muramidase
APHEDCCB_00813 1.9e-83 L transposition
APHEDCCB_00814 2.6e-166 cpsY K Transcriptional regulator
APHEDCCB_00815 0.0 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
APHEDCCB_00816 1.2e-57 phnA P Alkylphosphonate utilization operon protein PhnA
APHEDCCB_00817 2e-104 artQ P ABC transporter (Permease
APHEDCCB_00818 1.8e-113 glnQ 3.6.3.21 E abc transporter atp-binding protein
APHEDCCB_00819 1.1e-158 aatB ET ABC transporter substrate-binding protein
APHEDCCB_00820 3.5e-40 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APHEDCCB_00821 1.7e-16 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APHEDCCB_00822 1.9e-110 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APHEDCCB_00823 2.1e-07
APHEDCCB_00824 6.6e-62 adhP 1.1.1.1 C alcohol dehydrogenase
APHEDCCB_00825 6.1e-112 adhP 1.1.1.1 C alcohol dehydrogenase
APHEDCCB_00827 3e-21
APHEDCCB_00828 5.5e-161 res_1 3.1.21.5 S Type III restriction
APHEDCCB_00829 0.0 res_1 3.1.21.5 S Type III restriction
APHEDCCB_00830 2e-158 sthIM 2.1.1.72 L DNA methylase
APHEDCCB_00831 5.8e-89 sthIM 2.1.1.72 L Adenine specific DNA methylase Mod
APHEDCCB_00832 4.3e-302 guaA 2.3.1.128, 6.3.5.2 F Catalyzes the synthesis of GMP from XMP
APHEDCCB_00833 2e-126 gntR1 K transcriptional
APHEDCCB_00834 1.1e-53 ylxM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
APHEDCCB_00835 5.9e-275 ffh 3.6.5.4 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APHEDCCB_00836 2.4e-87 niaX
APHEDCCB_00837 7.8e-91 niaR S small molecule binding protein (contains 3H domain)
APHEDCCB_00838 1.6e-128 K DNA-binding helix-turn-helix protein
APHEDCCB_00839 4.2e-158 ylqF S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
APHEDCCB_00840 1.2e-135 rnhB 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APHEDCCB_00841 8.2e-168 GK ROK family
APHEDCCB_00842 8.3e-159 dprA LU DNA protecting protein DprA
APHEDCCB_00843 0.0 topA 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
APHEDCCB_00844 3.9e-145 S TraX protein
APHEDCCB_00845 2.2e-122 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
APHEDCCB_00846 2.6e-250 T PhoQ Sensor
APHEDCCB_00847 9.6e-258 trmFO 2.1.1.74 J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
APHEDCCB_00848 1.1e-152 XK27_05470 E Methionine synthase
APHEDCCB_00849 1.7e-75 ndk 2.7.4.6 F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
APHEDCCB_00850 2.7e-48 pspE P Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APHEDCCB_00851 1.8e-51 IQ Acetoin reductase
APHEDCCB_00852 3.9e-19 IQ Acetoin reductase
APHEDCCB_00853 0.0 lepA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
APHEDCCB_00854 1.8e-156 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
APHEDCCB_00857 1.3e-212 pqqE C radical SAM domain protein
APHEDCCB_00858 3.9e-136 speB 3.5.3.11 E hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
APHEDCCB_00859 6.6e-61 EGP Major facilitator Superfamily
APHEDCCB_00860 0.0 alsS 2.2.1.6 EH Belongs to the TPP enzyme family
APHEDCCB_00861 3e-133 budA 4.1.1.5 H Belongs to the alpha-acetolactate decarboxylase family
APHEDCCB_00862 4.3e-13
APHEDCCB_00863 1.3e-29 L Transposase
APHEDCCB_00864 6.4e-104 V ABC transporter (Permease
APHEDCCB_00865 2.8e-115 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
APHEDCCB_00866 1.6e-10
APHEDCCB_00867 9e-98 K Transcriptional regulator, TetR family
APHEDCCB_00868 1.8e-159 czcD P cation diffusion facilitator family transporter
APHEDCCB_00869 2.7e-210 hemH 4.99.1.1, 4.99.1.9 H Catalyzes the ferrous insertion into protoporphyrin IX
APHEDCCB_00870 6.2e-196 adhB 1.1.1.1, 1.1.1.14 E Dehydrogenase
APHEDCCB_00871 6e-08 S Hydrolases of the alpha beta superfamily
APHEDCCB_00872 7.9e-17 S Alpha/beta hydrolase of unknown function (DUF915)
APHEDCCB_00873 4.5e-79 S Alpha/beta hydrolase of unknown function (DUF915)
APHEDCCB_00876 1.2e-143 2.4.2.3 F Phosphorylase superfamily
APHEDCCB_00877 4.1e-118 gph 3.1.3.18 S HAD hydrolase, family IA, variant 1
APHEDCCB_00878 1.8e-24 yclQ P ABC-type enterochelin transport system, periplasmic component
APHEDCCB_00879 3.6e-18 yclQ P ABC-type enterochelin transport system, periplasmic component
APHEDCCB_00881 9.2e-311 FbpA K RNA-binding protein homologous to eukaryotic snRNP
APHEDCCB_00882 8.2e-190
APHEDCCB_00883 3.1e-89 FNV0100 F Belongs to the Nudix hydrolase family
APHEDCCB_00884 3.5e-28 3.4.13.21 I Protein conserved in bacteria
APHEDCCB_00886 5.7e-118 S TraX protein
APHEDCCB_00887 1.7e-96 thiJ 2.7.11.1, 3.5.1.124 S DJ-1 family
APHEDCCB_00888 1.3e-148 pyrK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )
APHEDCCB_00889 9.3e-175 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
APHEDCCB_00890 1.2e-180 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
APHEDCCB_00891 3.7e-54 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
APHEDCCB_00892 6.8e-133 cas6 S Pfam:DUF2276
APHEDCCB_00893 0.0 csm1 S CRISPR-associated protein Csm1 family
APHEDCCB_00894 2.5e-62 csm2 L Csm2 Type III-A
APHEDCCB_00895 1.6e-117 csm3 L RAMP superfamily
APHEDCCB_00896 2.3e-167 csm4 L CRISPR-associated RAMP protein, Csm4 family
APHEDCCB_00897 2e-205 csm5 L CRISPR-associated RAMP protein, Csm5 family
APHEDCCB_00899 9.5e-32 csm6 S Psort location Cytoplasmic, score
APHEDCCB_00900 7e-127 pyrF 4.1.1.23 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
APHEDCCB_00901 7.5e-112 pyrE 2.4.2.10, 4.1.1.23 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APHEDCCB_00902 1.2e-63 nylA 3.5.1.4 J Belongs to the amidase family
APHEDCCB_00904 3.9e-265 dtpT E transporter
APHEDCCB_00905 1e-103 nylA 3.5.1.4 J Belongs to the amidase family
APHEDCCB_00906 8.8e-134 yckB ET Belongs to the bacterial solute-binding protein 3 family
APHEDCCB_00907 1.8e-67 yecS P ABC transporter (Permease
APHEDCCB_00909 8.1e-114 sasH 3.1.3.5, 3.6.1.45 F Belongs to the 5'-nucleotidase family
APHEDCCB_00910 9.8e-35 3.1.3.6, 3.1.4.16 F nucleotide catabolic process
APHEDCCB_00911 1.4e-104 yfiF3 K sequence-specific DNA binding
APHEDCCB_00912 1e-49 L Transposase
APHEDCCB_00913 8.9e-164 L Transposase
APHEDCCB_00914 1.6e-247 mnmE S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
APHEDCCB_00915 1.8e-240 agcS E (Alanine) symporter
APHEDCCB_00916 0.0 pcrA 3.6.4.12 L ATP-dependent DNA helicase
APHEDCCB_00917 4.6e-241 metY 2.5.1.49 E o-acetylhomoserine
APHEDCCB_00918 1.8e-59 Q phosphatase activity
APHEDCCB_00919 9.3e-62 S haloacid dehalogenase-like hydrolase
APHEDCCB_00920 3.5e-88 tpx 1.11.1.15 O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
APHEDCCB_00921 1.1e-110 hsdS2 2.1.1.72 V Type I restriction modification DNA specificity domain
APHEDCCB_00922 6.3e-32 M1-755 P Hemerythrin HHE cation binding domain protein
APHEDCCB_00923 5.4e-95 XK27_04775 S hemerythrin HHE cation binding domain
APHEDCCB_00924 2.6e-49 XK27_04775 S hemerythrin HHE cation binding domain
APHEDCCB_00925 4.9e-151 truB 5.4.99.25 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
APHEDCCB_00926 5.3e-175 ribF 2.7.1.26, 2.7.7.2 H Belongs to the ribF family
APHEDCCB_00927 5.5e-71 spxA 1.20.4.1 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
APHEDCCB_00928 1.9e-43 yktA S Belongs to the UPF0223 family
APHEDCCB_00929 1.9e-141 suhB 3.1.3.25 G Belongs to the inositol monophosphatase superfamily
APHEDCCB_00930 3e-256 rsmF 2.1.1.176, 2.1.1.178 J NOL1 NOP2 sun family protein
APHEDCCB_00931 4.3e-158 pstS P phosphate
APHEDCCB_00932 1.8e-154 pstC P probably responsible for the translocation of the substrate across the membrane
APHEDCCB_00933 1.2e-155 pstA P phosphate transport system permease
APHEDCCB_00934 5.2e-150 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
APHEDCCB_00935 1.7e-139 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
APHEDCCB_00936 2.4e-113 phoU P Plays a role in the regulation of phosphate uptake
APHEDCCB_00937 0.0 pepN 3.4.11.2 E aminopeptidase
APHEDCCB_00938 1.6e-194 xerS D Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division
APHEDCCB_00940 1.9e-186 lplA 6.3.1.20 H Lipoate-protein ligase
APHEDCCB_00941 3e-08
APHEDCCB_00943 0.0 glgP 2.4.1.1 GT35 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
APHEDCCB_00944 1.3e-271 malQ 2.4.1.25 GH77 G 4-alpha-glucanotransferase
APHEDCCB_00945 1.3e-48 malR K Transcriptional regulator
APHEDCCB_00946 2.3e-23 L Transposase
APHEDCCB_00947 4.6e-25 tatA U protein secretion
APHEDCCB_00948 4.4e-121 tatC U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APHEDCCB_00949 7.2e-303 ywbL P COG0672 High-affinity Fe2 Pb2 permease
APHEDCCB_00950 5.6e-233 ycdB P peroxidase
APHEDCCB_00951 3.2e-153 ycdO P periplasmic lipoprotein involved in iron transport
APHEDCCB_00952 7.7e-139 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
APHEDCCB_00953 1.5e-29 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
APHEDCCB_00954 1.9e-125 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
APHEDCCB_00955 2.8e-54 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
APHEDCCB_00956 3.8e-280 3.5.1.28 NU amidase activity
APHEDCCB_00957 4.8e-60 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
APHEDCCB_00958 0.0 lpdA 1.8.1.4 C Dehydrogenase
APHEDCCB_00959 5.4e-200 acoC 2.3.1.12 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
APHEDCCB_00960 3.7e-182 acoB 1.2.4.1, 1.2.4.4 C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
APHEDCCB_00961 1.7e-184 acoA 1.2.4.1, 1.2.4.4 C Dehydrogenase E1 component
APHEDCCB_00962 3.6e-46 hpk9 2.7.13.3 T protein histidine kinase activity
APHEDCCB_00963 3.5e-241 cas3 L CRISPR-associated helicase, Cas3
APHEDCCB_00964 0.0 S the current gene model (or a revised gene model) may contain a frame shift
APHEDCCB_00965 2.4e-234 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
APHEDCCB_00966 2.9e-127 ung 3.2.2.27 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
APHEDCCB_00967 1.6e-216 yeaB K Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
APHEDCCB_00968 5.9e-22 dacA1 3.4.16.4 M Belongs to the peptidase S11 family
APHEDCCB_00969 3.9e-24 3.4.16.4 M Belongs to the peptidase S11 family
APHEDCCB_00970 1.6e-126 3.4.16.4 M Belongs to the peptidase S11 family
APHEDCCB_00971 1.2e-157 rssA S Phospholipase, patatin family
APHEDCCB_00972 1.8e-69 estA E GDSL-like protein
APHEDCCB_00973 3.4e-29 estA E Lysophospholipase L1 and related esterases
APHEDCCB_00974 1.6e-291 S unusual protein kinase
APHEDCCB_00975 4.9e-39 S granule-associated protein
APHEDCCB_00976 2.1e-35 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
APHEDCCB_00977 3.5e-138 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
APHEDCCB_00978 2e-18 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
APHEDCCB_00979 1.3e-199 S hmm pf01594
APHEDCCB_00980 3.9e-61 G Belongs to the phosphoglycerate mutase family
APHEDCCB_00981 3.5e-29 G Belongs to the phosphoglycerate mutase family
APHEDCCB_00982 7.6e-70 supH 3.1.3.102, 3.1.3.104 Q phosphatase activity
APHEDCCB_00983 2.9e-94 V VanZ like family
APHEDCCB_00984 3.4e-194 wbbI M transferase activity, transferring glycosyl groups
APHEDCCB_00985 2.9e-212 glf 5.4.99.9 M UDP-galactopyranose mutase
APHEDCCB_00986 7e-243 epsU S Polysaccharide biosynthesis protein
APHEDCCB_00987 7e-172
APHEDCCB_00988 2.7e-148 M Glycosyltransferase like family 2
APHEDCCB_00989 1.1e-122 M Glycosyltransferase, group 2 family protein
APHEDCCB_00991 1.6e-77 M transferase activity, transferring glycosyl groups
APHEDCCB_00992 3.7e-210 wcoF M Glycosyltransferase, group 1 family protein
APHEDCCB_00993 4.5e-219 rgpAc GT4 M group 1 family protein
APHEDCCB_00994 1.2e-250 cpsE M Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
APHEDCCB_00995 7.2e-114 cpsD D COG0489 ATPases involved in chromosome partitioning
APHEDCCB_00996 1.1e-103 cps4C M biosynthesis protein
APHEDCCB_00997 3e-136 cpsB 3.1.3.48 GM Capsular polysaccharide biosynthesis protein
APHEDCCB_00998 1.3e-252 cps4A K Cell envelope-like function transcriptional attenuator common domain protein
APHEDCCB_00999 2e-129 deoD 2.4.2.1, 2.4.2.28 F purine nucleoside phosphorylase
APHEDCCB_01000 7e-38 yfeJ 6.3.5.2 F glutamine amidotransferase
APHEDCCB_01001 6.3e-67 yfeJ 6.3.5.2 F glutamine amidotransferase
APHEDCCB_01002 2.1e-40 clcA_2 P chloride
APHEDCCB_01003 1.8e-51 clcA_2 P chloride channel
APHEDCCB_01004 4e-150 punA 2.4.2.1 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
APHEDCCB_01005 8.1e-41 S Protein of unknown function (DUF1697)
APHEDCCB_01006 7.1e-236 deoB 5.4.2.7 G Phosphotransfer between the C1 and C5 carbon atoms of pentose
APHEDCCB_01007 1.7e-122 rpiA 2.7.1.12, 2.7.1.15, 5.3.1.6 G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
APHEDCCB_01009 6.1e-22 V Glucan-binding protein C
APHEDCCB_01010 1e-110 ung2 3.2.2.27 L Uracil-DNA glycosylase
APHEDCCB_01011 2.4e-275 pepV 3.5.1.18 E Dipeptidase
APHEDCCB_01012 6.4e-27 dmpI 5.3.2.6 G Belongs to the 4-oxalocrotonate tautomerase family
APHEDCCB_01013 1.7e-47 XK27_03610 K Gnat family
APHEDCCB_01014 1.6e-24 L Transposase
APHEDCCB_01015 5.8e-42 L Transposase
APHEDCCB_01016 1.5e-56 rplT J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
APHEDCCB_01017 2.1e-28 rpmI J Belongs to the bacterial ribosomal protein bL35 family
APHEDCCB_01018 3.5e-86 infC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
APHEDCCB_01019 2.5e-121 cmk 1.17.7.4, 2.5.1.19, 2.7.1.26, 2.7.4.25, 2.7.7.2, 6.3.2.1 F Belongs to the cytidylate kinase family. Type 1 subfamily
APHEDCCB_01020 3.9e-15 M LysM domain
APHEDCCB_01021 2.9e-90 ebsA S Family of unknown function (DUF5322)
APHEDCCB_01022 1.8e-234 pepT 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
APHEDCCB_01023 4.2e-98 lepB 3.4.21.89 U Belongs to the peptidase S26 family
APHEDCCB_01024 3.1e-223 G COG0457 FOG TPR repeat
APHEDCCB_01025 5.2e-175 yubA S permease
APHEDCCB_01026 4.6e-93 mutX 3.6.1.55 F NTP pyrophosphohydrolases including oxidative damage repair enzymes
APHEDCCB_01027 3.6e-163 ftsX D Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation
APHEDCCB_01028 2.5e-124 ftsE D cell division ATP-binding protein FtsE
APHEDCCB_01029 2.1e-182 prfB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APHEDCCB_01030 1.2e-202 queG 1.17.99.6 C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APHEDCCB_01031 4.3e-180 yjjH S Calcineurin-like phosphoesterase
APHEDCCB_01032 5.2e-136 nfrA 1.5.1.38, 1.5.1.39 C nitroreductase
APHEDCCB_01033 0.0 pacL 3.6.3.8 P cation transport ATPase
APHEDCCB_01034 2.6e-67 ywiB S Domain of unknown function (DUF1934)
APHEDCCB_01035 6.3e-51 XK27_00115 2.3.1.128 K acetyltransferase
APHEDCCB_01036 9.2e-147 yidA S hydrolases of the HAD superfamily
APHEDCCB_01037 9e-231 murM 2.3.2.10, 2.3.2.16 V protein involved in methicillin resistance
APHEDCCB_01038 1e-153 vicX 3.1.26.11 S Metal-dependent hydrolases of the beta-lactamase superfamily I
APHEDCCB_01039 1.4e-245 vicK 2.7.13.3 T Histidine kinase
APHEDCCB_01040 2.9e-128 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
APHEDCCB_01041 2.1e-140 glnQ 3.6.3.21 E abc transporter atp-binding protein
APHEDCCB_01042 3.1e-150 peb1A ET ABC-type amino acid transport signal transduction systems, periplasmic component domain
APHEDCCB_01043 7.7e-118 gltJ P ABC transporter (Permease
APHEDCCB_01044 4.2e-110 tcyB_2 P ABC transporter (permease)
APHEDCCB_01045 2.4e-124 endA F DNA RNA non-specific endonuclease
APHEDCCB_01046 1.2e-25 epuA S DNA-directed RNA polymerase subunit beta
APHEDCCB_01047 1.1e-231 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APHEDCCB_01049 2.7e-196 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
APHEDCCB_01050 5.9e-26 G Domain of unknown function (DUF4832)
APHEDCCB_01051 2.1e-203 metK 2.5.1.6 H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
APHEDCCB_01052 4.2e-175 birA 6.3.4.15 HK Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
APHEDCCB_01053 3.2e-295 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APHEDCCB_01054 1.6e-88 ytsP 1.8.4.14 T GAF domain-containing protein
APHEDCCB_01055 4.2e-164 miaA 2.5.1.75 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
APHEDCCB_01056 1.9e-20 WQ51_02665 S Protein of unknown function (DUF3042)
APHEDCCB_01057 5.8e-80
APHEDCCB_01059 1.1e-56 rplS J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
APHEDCCB_01060 2.8e-219 XK27_05110 P chloride
APHEDCCB_01061 8.7e-41 pheA 1.3.1.12, 2.3.1.79, 4.2.1.51, 5.4.99.5 E Chorismate mutase
APHEDCCB_01062 1.4e-281 clcA P Chloride transporter, ClC family
APHEDCCB_01063 2.3e-75 fld C Flavodoxin
APHEDCCB_01065 4.7e-126 XK27_08875 O Zinc-dependent metalloprotease
APHEDCCB_01066 3.5e-151 estA CE1 S Putative esterase
APHEDCCB_01067 3.5e-310 rnjB S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
APHEDCCB_01068 4.4e-135 XK27_08845 S abc transporter atp-binding protein
APHEDCCB_01069 2e-147 XK27_08840 S Belongs to the binding-protein-dependent transport system permease family
APHEDCCB_01070 9.5e-178 XK27_08835 S ABC transporter substrate binding protein
APHEDCCB_01071 3.2e-17 S Domain of unknown function (DUF4649)
APHEDCCB_01073 8.1e-42 Q the current gene model (or a revised gene model) may contain a frame shift
APHEDCCB_01074 2.7e-26 Q the current gene model (or a revised gene model) may contain a frame shift
APHEDCCB_01075 3.2e-09 Q the current gene model (or a revised gene model) may contain a frame shift
APHEDCCB_01077 1.5e-275 pyk 2.7.1.40, 2.7.7.4 G Belongs to the pyruvate kinase family
APHEDCCB_01078 2.2e-185 pfkA 2.7.1.11 F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
APHEDCCB_01079 0.0 dnaE 2.7.7.7 L DNA polymerase
APHEDCCB_01080 1.4e-152 sua5 2.7.7.87 J Belongs to the SUA5 family
APHEDCCB_01081 3.1e-112 leuD 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
APHEDCCB_01082 6.8e-275 leuC 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
APHEDCCB_01083 2.5e-43 ysdA L Membrane
APHEDCCB_01084 6.6e-190 leuB 1.1.1.85 CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
APHEDCCB_01085 3.4e-291 leuA 2.3.3.13 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APHEDCCB_01086 4.6e-131 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
APHEDCCB_01087 3.6e-179 pyrD 1.3.1.14, 1.3.98.1 F Catalyzes the conversion of dihydroorotate to orotate
APHEDCCB_01089 2.8e-39 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
APHEDCCB_01090 1.7e-83 ypmS S Protein conserved in bacteria
APHEDCCB_01091 6e-144 ypmR E lipolytic protein G-D-S-L family
APHEDCCB_01092 1e-148 DegV S DegV family
APHEDCCB_01093 5.8e-305 recN L May be involved in recombinational repair of damaged DNA
APHEDCCB_01094 3.7e-73 argR K Regulates arginine biosynthesis genes
APHEDCCB_01095 5e-159 rrmJ 2.1.1.226, 2.1.1.227 J Ribosomal RNA large subunit methyltransferase J
APHEDCCB_01096 3e-159 ispA 2.5.1.1, 2.5.1.10, 2.5.1.29, 2.5.1.90 H Belongs to the FPP GGPP synthase family
APHEDCCB_01097 3.5e-29 xseB 3.1.11.6 L exodeoxyribonuclease VII activity
APHEDCCB_01098 1.2e-247 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
APHEDCCB_01101 3.4e-120 nth 4.2.99.18 L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APHEDCCB_01102 2.9e-125 dnaD
APHEDCCB_01103 9.3e-183 metA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APHEDCCB_01104 2e-94 apt 2.4.2.22, 2.4.2.7 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APHEDCCB_01105 0.0 recJ L Single-strand DNA-specific exonuclease, C terminal domain
APHEDCCB_01106 6.7e-139 XK27_05435 1.1.1.100 S Belongs to the short-chain dehydrogenases reductases (SDR) family
APHEDCCB_01107 9.2e-175 rnz 3.1.26.11 S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
APHEDCCB_01108 4.2e-118 galT 2.7.7.12 G UDPglucose--hexose-1-phosphate uridylyltransferase
APHEDCCB_01109 1.4e-223 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APHEDCCB_01110 5.6e-240 rodA D Belongs to the SEDS family
APHEDCCB_01111 1.8e-50 hisE 3.5.4.19, 3.6.1.31, 5.3.1.16 E Phosphoribosyl-ATP
APHEDCCB_01112 5.5e-61 hisI 3.5.4.19, 3.5.4.25, 3.6.1.31, 5.3.1.16 E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
APHEDCCB_01113 9.6e-138 hisF 3.5.4.19, 3.6.1.31 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
APHEDCCB_01114 1.7e-131 hisA 5.3.1.16 E 1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
APHEDCCB_01115 1.6e-111 hisH E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
APHEDCCB_01116 2.2e-105 hisB 1.1.1.23, 2.6.1.9, 3.1.3.15, 4.2.1.19 E imidazoleglycerol-phosphate dehydratase
APHEDCCB_01117 2.6e-228 hisD 1.1.1.23, 1.1.1.308 E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APHEDCCB_01118 1.4e-116 hisG 2.4.2.17 E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
APHEDCCB_01119 5.7e-183 hisZ 2.4.2.17, 6.1.1.21 E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
APHEDCCB_01120 4.1e-195 hisC 2.6.1.9 E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APHEDCCB_01122 6.6e-31 L Integrase core domain protein
APHEDCCB_01123 1.6e-55 L transposition
APHEDCCB_01124 8.2e-22 L Transposase
APHEDCCB_01125 5.2e-36 L transposase activity
APHEDCCB_01126 1.3e-22 XK27_08085
APHEDCCB_01127 3.1e-90 XK27_08080 3.1.1.53 G Exopolysaccharide biosynthesis protein
APHEDCCB_01128 7.9e-10 XK27_08080 3.1.1.53 G Exopolysaccharide biosynthesis protein
APHEDCCB_01129 5.8e-140 hisK 3.1.3.15 E Histidinol phosphatase and related hydrolases of the PHP family
APHEDCCB_01130 3.4e-120 ylfI S tigr01906
APHEDCCB_01131 5.9e-143 nagD 2.7.1.25, 3.1.3.41 G Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
APHEDCCB_01132 1.5e-143 fat 3.1.2.21 I Acyl-ACP thioesterase
APHEDCCB_01133 1.5e-216 hemN H Involved in the biosynthesis of porphyrin-containing compound
APHEDCCB_01136 1.9e-205 rfbB 4.2.1.46 M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
APHEDCCB_01137 8.3e-113 rmlC 1.1.1.133, 5.1.3.13 M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
APHEDCCB_01138 1.9e-161 rfbA 2.7.7.24 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
APHEDCCB_01139 7.6e-205 yurR 1.4.5.1 E oxidoreductase
APHEDCCB_01140 5.7e-102 zupT P Mediates zinc uptake. May also transport other divalent cations
APHEDCCB_01141 9.6e-149 yqfO 3.5.4.16 S Belongs to the GTP cyclohydrolase I type 2 NIF3 family
APHEDCCB_01142 2.7e-123 trmK 2.1.1.217 S SAM-dependent methyltransferase
APHEDCCB_01143 1.7e-70 gtrA S GtrA-like protein
APHEDCCB_01144 1.5e-250 glmM 5.4.2.10 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APHEDCCB_01145 6e-169 ybbR S Protein conserved in bacteria
APHEDCCB_01146 5.6e-124 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
APHEDCCB_01147 7.5e-255 murD 3.4.21.10, 6.3.2.13, 6.3.2.9 M Mur ligase, middle domain protein
APHEDCCB_01148 8.7e-150 cobQ S glutamine amidotransferase
APHEDCCB_01149 0.0 mprF 2.3.2.3 J Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
APHEDCCB_01150 2.2e-131 pip 1.11.1.10 S Alpha beta hydrolase
APHEDCCB_01151 0.0 uup S abc transporter atp-binding protein
APHEDCCB_01152 2.1e-114 udk 2.7.1.48 F Cytidine monophosphokinase
APHEDCCB_01153 2.1e-178 yfmL 3.6.4.13 L DEAD DEAH box helicase
APHEDCCB_01154 2.1e-28 6.3.2.2, 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
APHEDCCB_01155 8.6e-265 gapN 1.2.1.9 C Belongs to the aldehyde dehydrogenase family
APHEDCCB_01156 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APHEDCCB_01157 7.9e-39 ptsH G phosphocarrier protein Hpr
APHEDCCB_01158 9.7e-222 icd 1.1.1.42 C Isocitrate dehydrogenase
APHEDCCB_01159 1.5e-211 citZ 2.3.3.1 C Belongs to the citrate synthase family
APHEDCCB_01160 0.0 acnA 4.2.1.3 C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
APHEDCCB_01161 7.7e-43 acnA 4.2.1.3 C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
APHEDCCB_01162 8.5e-34 nrdH O Glutaredoxin
APHEDCCB_01163 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APHEDCCB_01164 1.7e-184 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APHEDCCB_01166 1.9e-71 L Transposase (IS116 IS110 IS902 family)
APHEDCCB_01167 3.6e-61 L Transposase (IS116 IS110 IS902 family)
APHEDCCB_01168 1.8e-165 ypuA S secreted protein
APHEDCCB_01169 3.9e-53 yaeR E COG0346 LactoylglutaTHIone lyase and related lyases
APHEDCCB_01170 1.7e-134 srtA 3.4.22.70 M Sortase (surface protein transpeptidase)
APHEDCCB_01171 0.0 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APHEDCCB_01172 7e-181 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
APHEDCCB_01173 2.6e-258 noxE P NADH oxidase
APHEDCCB_01174 2.5e-294 yfmM S abc transporter atp-binding protein
APHEDCCB_01175 9.5e-84 XK27_01265 S ECF-type riboflavin transporter, S component
APHEDCCB_01176 9.3e-87 pdxK 2.7.1.35 H Belongs to the pyridoxine kinase family
APHEDCCB_01177 5.5e-42 pdxK 2.7.1.35 H Belongs to the pyridoxine kinase family
APHEDCCB_01178 2e-86 S ECF-type riboflavin transporter, S component
APHEDCCB_01180 7.7e-241 XK27_08130 K Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
APHEDCCB_01181 2e-55 nrdD_1 1.1.98.6, 1.17.4.1 F Ribonucleoside-triphosphate reductase
APHEDCCB_01183 0.0 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
APHEDCCB_01184 9.9e-94 paiA 2.3.1.57 K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
APHEDCCB_01185 1.1e-197 pheS 6.1.1.20 J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
APHEDCCB_01186 0.0 smc D Required for chromosome condensation and partitioning
APHEDCCB_01187 8.4e-125 rnc 3.1.26.3 J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
APHEDCCB_01188 6.6e-173 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APHEDCCB_01189 1.1e-198 asd 1.2.1.11 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APHEDCCB_01190 2.4e-92 pat 2.3.1.183 M acetyltransferase
APHEDCCB_01191 9e-278 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APHEDCCB_01192 0.0 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
APHEDCCB_01193 3.1e-127 yjjG 3.1.3.102, 3.1.3.104, 3.1.3.5, 3.8.1.2 E hydrolase
APHEDCCB_01194 1.2e-62 bioY S biotin transmembrane transporter activity
APHEDCCB_01195 9.8e-88 proW P Binding-protein-dependent transport system inner membrane component
APHEDCCB_01196 1.5e-138 proV E abc transporter atp-binding protein
APHEDCCB_01197 2e-169 proX M ABC transporter, substrate-binding protein, QAT family
APHEDCCB_01198 3e-111 proWZ P ABC transporter (Permease
APHEDCCB_01199 1.2e-280 hutH 4.3.1.3 E Histidine ammonia-lyase
APHEDCCB_01200 1.6e-205 S Protein of unknown function (DUF917)
APHEDCCB_01201 1.4e-308 hutU 4.2.1.49 E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
APHEDCCB_01202 1.6e-59 sdaAB 4.3.1.17 E L-serine dehydratase
APHEDCCB_01203 4.4e-101 desR K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
APHEDCCB_01204 9.7e-192 desK 2.7.13.3 T Histidine kinase
APHEDCCB_01205 1.4e-133 yvfS V ABC-2 type transporter
APHEDCCB_01206 3.7e-157 XK27_09825 V abc transporter atp-binding protein
APHEDCCB_01210 3.3e-212 EGP Major facilitator Superfamily
APHEDCCB_01211 0.0 2.7.7.73, 2.7.7.80 E metalloendopeptidase activity
APHEDCCB_01212 1.2e-152 mutR K Transcriptional activator, Rgg GadR MutR family
APHEDCCB_01213 4.6e-42 3.6.1.55 F NUDIX domain
APHEDCCB_01215 3.7e-122 S An automated process has identified a potential problem with this gene model
APHEDCCB_01216 3e-25 XK27_09825 V 'abc transporter, ATP-binding protein
APHEDCCB_01217 2.7e-14 liaI KT membrane
APHEDCCB_01218 2.6e-30 liaI KT membrane
APHEDCCB_01219 6e-99 XK27_05000 S Fe-S-cluster oxidoreductase
APHEDCCB_01220 0.0 V ABC transporter (permease)
APHEDCCB_01221 1.9e-133 macB2 V ABC transporter, ATP-binding protein
APHEDCCB_01222 6.2e-166 T Histidine kinase
APHEDCCB_01223 4.6e-123 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
APHEDCCB_01224 2e-77 xpt 2.4.2.22, 2.4.2.7 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
APHEDCCB_01225 3.3e-69 pbuX F xanthine permease
APHEDCCB_01226 9.2e-119 pbuX F xanthine permease
APHEDCCB_01227 3.4e-247 norM V Multidrug efflux pump
APHEDCCB_01228 4.3e-188 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APHEDCCB_01229 6.6e-235 brnQ E Component of the transport system for branched-chain amino acids
APHEDCCB_01230 9.4e-65 manA 5.3.1.8 G mannose-6-phosphate isomerase
APHEDCCB_01231 8.2e-57 manA 5.3.1.8 G mannose-6-phosphate isomerase
APHEDCCB_01232 4.8e-25 csbD K CsbD-like
APHEDCCB_01233 1.1e-227 yfnA E amino acid
APHEDCCB_01234 2.5e-109 XK27_02070 S nitroreductase
APHEDCCB_01235 2.2e-140 1.13.11.2 S glyoxalase
APHEDCCB_01236 5.6e-77 ywnA K Transcriptional regulator
APHEDCCB_01237 6.8e-156 E Alpha/beta hydrolase of unknown function (DUF915)
APHEDCCB_01238 7.9e-233 pts13C G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
APHEDCCB_01239 2.2e-111 drgA C Nitroreductase
APHEDCCB_01240 5e-66 yoaK S Protein of unknown function (DUF1275)
APHEDCCB_01242 6.8e-161 yvgN C reductase
APHEDCCB_01243 2.7e-182 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
APHEDCCB_01244 2.8e-282 XK27_07020 S Belongs to the UPF0371 family
APHEDCCB_01246 1.1e-37 BP1961 P nitric oxide dioxygenase activity
APHEDCCB_01247 1.4e-54 K response regulator
APHEDCCB_01248 9.3e-72 S Signal peptide protein, YSIRK family
APHEDCCB_01249 4.5e-61
APHEDCCB_01250 2e-244 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APHEDCCB_01251 1.1e-136
APHEDCCB_01252 5.3e-12 IQ PFAM AMP-dependent synthetase and ligase
APHEDCCB_01253 2.7e-12 IQ PFAM AMP-dependent synthetase and ligase
APHEDCCB_01254 5.8e-109 MA20_06410 E LysE type translocator
APHEDCCB_01255 5.6e-08
APHEDCCB_01256 2.7e-09
APHEDCCB_01257 0.0 M family 8
APHEDCCB_01258 1.8e-249 M the current gene model (or a revised gene model) may contain a
APHEDCCB_01259 5.9e-51 M YSIRK type signal peptide
APHEDCCB_01260 3e-92 S MucBP domain
APHEDCCB_01263 1.4e-115 hrtB V MacB-like periplasmic core domain
APHEDCCB_01264 5.5e-24 hrtB V ABC transporter (Permease
APHEDCCB_01265 6.3e-117 devA 3.6.3.25 V abc transporter atp-binding protein
APHEDCCB_01266 1.6e-118 V MatE
APHEDCCB_01268 3.9e-110 C Fe-S oxidoreductases
APHEDCCB_01269 1.2e-176 EGP Major Facilitator Superfamily
APHEDCCB_01270 5.5e-258 I radical SAM domain protein
APHEDCCB_01272 6.5e-159 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
APHEDCCB_01273 1.4e-150 L Integrase core domain protein
APHEDCCB_01274 1.8e-87 L transposase activity
APHEDCCB_01276 2.8e-85
APHEDCCB_01277 0.0 sbcC L ATPase involved in DNA repair
APHEDCCB_01278 2.6e-230 sbcD L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
APHEDCCB_01279 0.0 lacL 3.2.1.23 G -beta-galactosidase
APHEDCCB_01280 0.0 lacS G transporter
APHEDCCB_01281 4.9e-201 galM 5.1.3.3 G Catalyzes the interconversion of alpha and beta anomers of maltose
APHEDCCB_01282 4.3e-194 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
APHEDCCB_01283 1e-284 galT 2.7.7.12 G UDPglucose--hexose-1-phosphate uridylyltransferase
APHEDCCB_01284 4e-220 galK 2.7.1.6 G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
APHEDCCB_01285 1.8e-181 galR K Transcriptional regulator
APHEDCCB_01286 2.7e-08 L Integrase core domain protein
APHEDCCB_01287 1.2e-25 L transposition
APHEDCCB_01288 3.5e-228 zmpB M M26 IgA1-specific Metallo-endopeptidase C-terminal region
APHEDCCB_01289 6.7e-17 rtxA M M26 IgA1-specific Metallo-endopeptidase C-terminal region
APHEDCCB_01290 5.4e-26 V abc transporter atp-binding protein
APHEDCCB_01291 1.7e-20 V abc transporter atp-binding protein
APHEDCCB_01292 1.1e-40 V abc transporter atp-binding protein
APHEDCCB_01293 0.0 gshF 6.3.2.2, 6.3.2.29, 6.3.2.30, 6.3.2.4 H Belongs to the glutamate--cysteine ligase type 1 family
APHEDCCB_01294 6.4e-62 L Transposase
APHEDCCB_01295 7e-150 pulA 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
APHEDCCB_01296 1.8e-33 pulA 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
APHEDCCB_01297 1.7e-120 pulA 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
APHEDCCB_01298 0.0 ftsK D Belongs to the FtsK SpoIIIE SftA family
APHEDCCB_01299 1.6e-188 trxB1 1.18.1.2, 1.19.1.1 C Ferredoxin--NADP reductase
APHEDCCB_01300 2.1e-134 trmD 2.1.1.228, 4.6.1.12 J Belongs to the RNA methyltransferase TrmD family
APHEDCCB_01301 5.8e-94 rimM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
APHEDCCB_01304 2.2e-114 vraR K Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
APHEDCCB_01305 5.8e-175 vraS 2.7.13.3 T Histidine kinase
APHEDCCB_01306 3.7e-120 yvqF KT membrane
APHEDCCB_01307 0.0 prkC 2.7.11.1 KLT serine threonine protein kinase
APHEDCCB_01308 2e-132 stp 3.1.3.16 T phosphatase
APHEDCCB_01309 4.4e-247 sun 2.1.1.176 J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APHEDCCB_01310 1.6e-171 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
APHEDCCB_01311 0.0 priA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
APHEDCCB_01312 2.7e-46 rpoZ 2.7.7.6 K DNA-directed 5'-3' RNA polymerase activity
APHEDCCB_01313 9.8e-112 gmk 2.7.4.8 F Essential for recycling GMP and indirectly, cGMP
APHEDCCB_01314 6.7e-214 ftsY U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
APHEDCCB_01315 5.3e-150 XK27_02985 S overlaps another CDS with the same product name
APHEDCCB_01316 2.2e-145 supH S overlaps another CDS with the same product name
APHEDCCB_01317 1.6e-61 yvoA_1 K Transcriptional
APHEDCCB_01318 1.8e-119 skfE V abc transporter atp-binding protein
APHEDCCB_01319 3.1e-131 V ATPase activity
APHEDCCB_01320 1.2e-171 oppF P Belongs to the ABC transporter superfamily
APHEDCCB_01321 1.6e-202 oppD P Belongs to the ABC transporter superfamily
APHEDCCB_01322 3.5e-166 amiD P ABC transporter (Permease
APHEDCCB_01323 4.2e-270 amiC P ABC transporter (Permease
APHEDCCB_01324 0.0 amiA E ABC transporter, substrate-binding protein, family 5
APHEDCCB_01325 4.6e-24 oppF P Belongs to the ABC transporter superfamily
APHEDCCB_01326 3.2e-44 oppF P Belongs to the ABC transporter superfamily
APHEDCCB_01327 5.2e-40 tatD L Hydrolase, tatd
APHEDCCB_01328 9.9e-214 oxlT P COG0477 Permeases of the major facilitator superfamily
APHEDCCB_01329 8.5e-23 L Transposase
APHEDCCB_01330 4.1e-181 pta 2.3.1.8, 3.6.3.21 C phosphate acetyltransferase
APHEDCCB_01331 3.7e-173 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 J Responsible for synthesis of pseudouridine from uracil
APHEDCCB_01332 3.7e-151 nadK 2.7.1.23 H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
APHEDCCB_01333 6.1e-120 yjbM 2.7.6.5 S Gtp pyrophosphokinase
APHEDCCB_01334 1.5e-103 yjbK S Adenylate cyclase
APHEDCCB_01335 2.1e-177 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APHEDCCB_01336 7e-206 iscS 2.8.1.7 E Cysteine desulfurase
APHEDCCB_01337 2e-58 XK27_04120 S Putative amino acid metabolism
APHEDCCB_01338 3.6e-117 rex K Modulates transcription in response to changes in cellular NADH NAD( ) redox state
APHEDCCB_01339 1.6e-131 puuD T peptidase C26
APHEDCCB_01340 4.6e-115 radC E Belongs to the UPF0758 family
APHEDCCB_01341 1.7e-268 M Psort location CytoplasmicMembrane, score
APHEDCCB_01342 0.0 rgpF M Rhamnan synthesis protein F
APHEDCCB_01343 1.2e-302 GT4 M transferase activity, transferring glycosyl groups
APHEDCCB_01344 6.4e-229 rgpD 3.6.3.38 P Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system
APHEDCCB_01345 2.1e-143 rgpC GM Transport permease protein
APHEDCCB_01346 4.9e-176 rgpB GT2 M Glycosyltransferase, group 2 family protein
APHEDCCB_01347 2.3e-228 rgpA GT4 M Domain of unknown function (DUF1972)
APHEDCCB_01348 2.9e-150 2.4.1.60 S Glycosyltransferase group 2 family protein
APHEDCCB_01349 4.6e-42 S Uncharacterized conserved protein (DUF2304)
APHEDCCB_01350 6.9e-130 arnC M group 2 family protein
APHEDCCB_01351 9.5e-183 cpsIaJ S Glycosyltransferase like family 2
APHEDCCB_01352 6e-185 S Glycosyltransferase like family 2
APHEDCCB_01353 4.8e-219 amrA S membrane protein involved in the export of O-antigen and teichoic acid
APHEDCCB_01354 4e-161 rfbD 1.1.1.133, 5.1.3.13 M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
APHEDCCB_01355 1.7e-132
APHEDCCB_01356 1.7e-102
APHEDCCB_01357 1.4e-170 yfdH GT2 M COG0463, glycosyltransferases involved in cell wall biogenesis
APHEDCCB_01358 3.4e-55 yitW K metal-sulfur cluster biosynthetic enzyme
APHEDCCB_01359 1.1e-201 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
APHEDCCB_01360 0.0 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
APHEDCCB_01361 5.5e-20 rpsU J Belongs to the bacterial ribosomal protein bS21 family
APHEDCCB_01362 1.1e-136 gltS ET Belongs to the bacterial solute-binding protein 3 family
APHEDCCB_01363 2.1e-202 arcT 2.6.1.1 E Aminotransferase
APHEDCCB_01364 7.2e-136 ET ABC transporter
APHEDCCB_01365 3.7e-143 ET Belongs to the bacterial solute-binding protein 3 family
APHEDCCB_01366 2.9e-84 mutT 3.6.1.55 F Nudix family
APHEDCCB_01367 0.0 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
APHEDCCB_01369 1.2e-55 V CAAX protease self-immunity
APHEDCCB_01370 2.6e-32 S CAAX amino terminal protease family protein
APHEDCCB_01371 0.0 glnP P ABC-type amino acid transport signal transduction systems periplasmic component domain
APHEDCCB_01372 1e-136 glnQ 3.6.3.21 E abc transporter atp-binding protein
APHEDCCB_01373 2.4e-16 XK27_00735
APHEDCCB_01374 1.5e-247 obg S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
APHEDCCB_01376 7.3e-135 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
APHEDCCB_01379 5.5e-65 paaI Q protein possibly involved in aromatic compounds catabolism
APHEDCCB_01380 3.3e-36 ycaO O OsmC-like protein
APHEDCCB_01381 3.2e-153 EG Permeases of the drug metabolite transporter (DMT) superfamily
APHEDCCB_01383 5.6e-110 csn2 S CRISPR-associated protein (Cas_Csn2)
APHEDCCB_01384 3.5e-52 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
APHEDCCB_01385 1.5e-163 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
APHEDCCB_01386 0.0 cas9 L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
APHEDCCB_01387 9.7e-115 serB 3.1.3.3 E phosphoserine phosphatase
APHEDCCB_01388 7.6e-300 ezrA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
APHEDCCB_01389 0.0 gyrB 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APHEDCCB_01390 2.6e-109 3.1.3.18 S IA, variant 1
APHEDCCB_01391 2.2e-117 lrgB M effector of murein hydrolase
APHEDCCB_01392 2.2e-58 lrgA S Effector of murein hydrolase LrgA
APHEDCCB_01394 5.4e-59 arsC 1.20.4.1 P Belongs to the ArsC family
APHEDCCB_01395 1.5e-52 ogt 2.1.1.63, 3.2.2.20 L methylated-DNA-[protein]-cysteine S-methyltransferase activity
APHEDCCB_01396 7e-220 serA 1.1.1.399, 1.1.1.95 EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APHEDCCB_01397 3.9e-104 wecD M Acetyltransferase GNAT family
APHEDCCB_01398 1.3e-209 serC 2.6.1.52 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
APHEDCCB_01399 5.1e-96 GK ROK family
APHEDCCB_01400 8.1e-72 gloA 4.4.1.5 E Lactoylglutathione lyase
APHEDCCB_01401 1.7e-47 XK27_08050 O stress-induced mitochondrial fusion
APHEDCCB_01402 1.3e-19 XK27_08050 O HflC and HflK could regulate a protease
APHEDCCB_01403 8.8e-206 potD P spermidine putrescine ABC transporter
APHEDCCB_01404 3e-134 potC P ABC-type spermidine putrescine transport system, permease component II
APHEDCCB_01405 3.7e-140 potB P ABC-type spermidine putrescine transport system, permease component I
APHEDCCB_01406 1.2e-213 potA 3.6.3.30, 3.6.3.31 P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
APHEDCCB_01407 7.8e-171 murB 1.3.1.98 M cell wall formation
APHEDCCB_01408 2.9e-87 folK 2.7.6.3, 4.1.2.25 H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
APHEDCCB_01409 1.2e-61 folB 1.13.11.81, 2.5.1.15, 2.7.6.3, 4.1.2.25, 5.1.99.8 H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
APHEDCCB_01410 1.2e-298 amy 3.2.1.1 GH13 G Belongs to the glycosyl hydrolase 13 family
APHEDCCB_01411 7e-147 folP 2.5.1.15, 2.7.6.3 H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
APHEDCCB_01412 1e-99 folE 3.5.4.16 F gtp cyclohydrolase
APHEDCCB_01413 0.0 ydaO E amino acid
APHEDCCB_01414 1.1e-239 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
APHEDCCB_01415 4.1e-37 ylqC L Belongs to the UPF0109 family
APHEDCCB_01416 2.4e-43 rpsP J Belongs to the bacterial ribosomal protein bS16 family
APHEDCCB_01417 6.9e-172 tehB 2.1.1.265 PQ tellurite resistance protein tehb
APHEDCCB_01418 8.2e-159 xth 3.1.11.2 L exodeoxyribonuclease III
APHEDCCB_01419 2.1e-74 S QueT transporter
APHEDCCB_01420 1.9e-55 L Transposase
APHEDCCB_01421 5.7e-186 yegS 2.7.1.107 I Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
APHEDCCB_01422 0.0 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APHEDCCB_01423 3.7e-85 ccl S cog cog4708
APHEDCCB_01424 7.4e-164 rbn E Belongs to the UPF0761 family
APHEDCCB_01425 1.5e-166 map 3.4.11.18 E Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed
APHEDCCB_01426 3.3e-231 ytoI K transcriptional regulator containing CBS domains
APHEDCCB_01427 2.4e-98 XK27_07830 2.3.1.128 J Acetyltransferase GNAT Family
APHEDCCB_01428 1e-232 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APHEDCCB_01429 0.0 comEC S Competence protein ComEC
APHEDCCB_01430 8.9e-98 comEA L COG1555 DNA uptake protein and related DNA-binding proteins
APHEDCCB_01431 1.7e-142 plsC 2.3.1.51 I Acyltransferase
APHEDCCB_01432 6e-78 nodB3 G polysaccharide deacetylase
APHEDCCB_01433 4.1e-22 nodB3 G polysaccharide deacetylase
APHEDCCB_01434 2.3e-139 yabB 2.1.1.223 L Methyltransferase
APHEDCCB_01435 1e-41 yazA L endonuclease containing a URI domain
APHEDCCB_01436 3.2e-252 cshA 3.6.4.13 JKL DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
APHEDCCB_01437 2.3e-154 corA P CorA-like protein
APHEDCCB_01438 1.9e-62 yjqA S Bacterial PH domain
APHEDCCB_01439 7.8e-100 thiT S Thiamine transporter
APHEDCCB_01440 2.3e-156 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
APHEDCCB_01441 1.9e-201 yjbB G Permeases of the major facilitator superfamily
APHEDCCB_01442 3.1e-300 prfC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
APHEDCCB_01443 1.4e-121 ywaF S Integral membrane protein (intg_mem_TP0381)
APHEDCCB_01444 1.5e-258 murF 6.3.2.10 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
APHEDCCB_01448 1.1e-155 cjaA ET ABC transporter substrate-binding protein
APHEDCCB_01449 1.4e-136 glnQ 3.6.3.21 E abc transporter atp-binding protein
APHEDCCB_01450 4.6e-115 P ABC transporter (Permease
APHEDCCB_01451 1e-114 papP P ABC transporter (Permease
APHEDCCB_01452 6.4e-193 ddl 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
APHEDCCB_01453 2.3e-30 copZ 2.7.7.77 P Heavy metal-associated domain protein
APHEDCCB_01454 0.0 copA 3.6.3.54 P P-type ATPase
APHEDCCB_01455 2.7e-73 copY K Copper transport repressor, CopY TcrY family
APHEDCCB_01456 2.1e-143 trpA 4.2.1.20 E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
APHEDCCB_01457 1.1e-228 trpB 4.2.1.20, 5.3.1.24 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
APHEDCCB_01458 3.3e-98 trpF 4.1.1.48, 4.2.1.160, 4.2.1.20, 5.3.1.24 E belongs to the TrpF family
APHEDCCB_01459 2.5e-133 trpC 4.1.1.48, 5.3.1.24 E Belongs to the TrpC family
APHEDCCB_01460 7.8e-180 trpD 2.4.2.18, 4.1.3.27 F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APHEDCCB_01461 3.6e-105 trpG 2.4.2.18, 2.6.1.85, 4.1.3.27 EH anthranilate
APHEDCCB_01462 6.9e-256 trpE 4.1.3.27 EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APHEDCCB_01463 8.1e-42 pchB 2.5.1.19, 4.2.1.10, 4.2.99.21, 5.4.99.5 E Chorismate mutase
APHEDCCB_01464 1.4e-54
APHEDCCB_01465 0.0 ctpE P E1-E2 ATPase
APHEDCCB_01466 3.9e-26
APHEDCCB_01467 1.2e-43 yaaK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
APHEDCCB_01468 9.7e-28 L transposase activity
APHEDCCB_01469 2.7e-129 K transcriptional regulator, MerR family
APHEDCCB_01470 1.4e-104 dnaQ 2.7.7.7 L DNA polymerase III
APHEDCCB_01471 1.2e-41 WQ51_02910 S Protein of unknown function, DUF536
APHEDCCB_01472 4.8e-63 XK27_02560 S cog cog2151
APHEDCCB_01473 0.0 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
APHEDCCB_01474 8.5e-226 ytfP S Flavoprotein
APHEDCCB_01476 3.1e-121 trmB 2.1.1.297, 2.1.1.33 J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
APHEDCCB_01477 1.2e-151 ytmP 2.7.1.89 M Phosphotransferase
APHEDCCB_01478 8.6e-182 ecsB U ABC transporter
APHEDCCB_01479 2.3e-133 ecsA V abc transporter atp-binding protein
APHEDCCB_01480 1.9e-71 hit FG Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
APHEDCCB_01481 2.3e-10
APHEDCCB_01482 1.3e-56 S CD20-like family
APHEDCCB_01483 3.2e-110
APHEDCCB_01484 0.0 clpL O ATP-dependent Clp protease ATP-binding subunit
APHEDCCB_01485 6.9e-206 ylbM S Belongs to the UPF0348 family
APHEDCCB_01486 3.8e-139 yqeM Q Methyltransferase domain protein
APHEDCCB_01487 6e-58 rsfS J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
APHEDCCB_01488 1.4e-107 nadD 2.7.6.3, 2.7.7.18 H HD superfamily hydrolase involved in NAD metabolism
APHEDCCB_01489 3.1e-118 nadD 2.7.7.18, 3.6.1.55 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
APHEDCCB_01490 3.5e-49 yhbY J RNA-binding protein
APHEDCCB_01491 8.4e-215 yqeH S in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis
APHEDCCB_01492 1.8e-98 yqeG S hydrolase of the HAD superfamily
APHEDCCB_01493 2.6e-153 yicL EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
APHEDCCB_01494 1.3e-57
APHEDCCB_01495 2.3e-273 gatB 6.1.1.12, 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APHEDCCB_01496 4.5e-269 gatA 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
APHEDCCB_01497 1.4e-47 gatC 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APHEDCCB_01498 6.3e-31 M lipopolysaccharide 3-alpha-galactosyltransferase activity
APHEDCCB_01499 2.2e-148 ascB 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
APHEDCCB_01500 5.1e-77 ascB 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
APHEDCCB_01501 2.3e-95 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APHEDCCB_01502 3.7e-154 hlpA M Belongs to the NlpA lipoprotein family
APHEDCCB_01503 6.8e-101 pncA Q isochorismatase
APHEDCCB_01504 1.2e-140 codY K DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
APHEDCCB_01505 3.7e-240 alaA 2.6.1.2, 2.6.1.66 E Aminotransferase
APHEDCCB_01506 2.4e-75 XK27_03180 T universal stress protein
APHEDCCB_01509 2e-157 pflA 1.97.1.4 C Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APHEDCCB_01510 7.1e-237 hlyX S COG1253 Hemolysins and related proteins containing CBS domains
APHEDCCB_01511 2.4e-144 modF 3.6.3.21, 3.6.3.34 P abc transporter atp-binding protein
APHEDCCB_01512 0.0 yjcE P NhaP-type Na H and K H antiporters
APHEDCCB_01514 1.4e-98 ytqB 2.1.1.176 J (SAM)-dependent
APHEDCCB_01515 3.8e-184 yhcC S radical SAM protein
APHEDCCB_01516 4.1e-195 ylbL T Belongs to the peptidase S16 family
APHEDCCB_01517 7.8e-88 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
APHEDCCB_01518 5.1e-93 rsmD 2.1.1.171 L Methyltransferase
APHEDCCB_01519 1.9e-172 trxB 1.8.1.9 C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
APHEDCCB_01520 3.2e-09 S Protein of unknown function (DUF4059)
APHEDCCB_01521 2.2e-131 tcyN 3.6.3.21 E abc transporter atp-binding protein
APHEDCCB_01522 1e-162 yxeN P ABC transporter (Permease
APHEDCCB_01523 1.5e-152 yxeM ET ABC-type amino acid transport signal transduction systems, periplasmic component domain
APHEDCCB_01525 1.6e-205 dinB 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APHEDCCB_01526 0.0 pflB 2.3.1.54 C formate acetyltransferase'
APHEDCCB_01527 1.8e-147 cah 4.2.1.1 P carbonic anhydrase
APHEDCCB_01528 2.1e-85 yjcF S COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
APHEDCCB_01529 1e-44 hsdS_1 3.1.21.3 V type I restriction modification DNA specificity domain
APHEDCCB_01530 2.9e-87 D nuclear chromosome segregation
APHEDCCB_01531 1.5e-127 ybbM S transport system, permease component
APHEDCCB_01532 1.2e-117 ybbL S abc transporter atp-binding protein
APHEDCCB_01533 4.5e-185 ampC V COG1680 Beta-lactamase class C and other penicillin binding proteins
APHEDCCB_01534 4.6e-140 cppA E CppA N-terminal
APHEDCCB_01535 5e-44 V CAAX protease self-immunity
APHEDCCB_01536 2.3e-164 gla U Belongs to the MIP aquaporin (TC 1.A.8) family
APHEDCCB_01537 0.0 pepX 3.4.14.11 E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline
APHEDCCB_01540 3e-47 spiA K sequence-specific DNA binding
APHEDCCB_01541 2.9e-28 blpT
APHEDCCB_01542 6.7e-98 blpT
APHEDCCB_01549 6.7e-26 S Bacteriocin class II with double-glycine leader peptide
APHEDCCB_01553 7.4e-135 agrA KT phosphorelay signal transduction system
APHEDCCB_01554 4.2e-237 blpH 2.7.13.3 T protein histidine kinase activity
APHEDCCB_01556 7.3e-237 mesE M Transport protein ComB
APHEDCCB_01557 5.8e-166 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
APHEDCCB_01558 3e-224 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
APHEDCCB_01559 0.0 mdlB V abc transporter atp-binding protein
APHEDCCB_01560 0.0 mdlA V abc transporter atp-binding protein
APHEDCCB_01562 1.7e-93 XK27_09885 V Glycopeptide antibiotics resistance protein
APHEDCCB_01563 7.9e-224 rlmN 2.1.1.192 J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
APHEDCCB_01564 2.3e-72 yutD J protein conserved in bacteria
APHEDCCB_01565 4.3e-269 yunD 3.1.3.5 F Belongs to the 5'-nucleotidase family
APHEDCCB_01567 7.2e-221 cshB 3.6.4.13 JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
APHEDCCB_01568 6.3e-185 mraY 2.7.8.13 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APHEDCCB_01569 0.0 ftsI 3.4.16.4 M penicillin-binding protein
APHEDCCB_01570 2.1e-46 ftsL D cell division protein FtsL
APHEDCCB_01571 1e-190 rsmH 2.1.1.199 J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
APHEDCCB_01572 4.8e-93
APHEDCCB_01573 7.5e-30
APHEDCCB_01575 8.7e-33 yhaI J Protein of unknown function (DUF805)
APHEDCCB_01576 1.3e-08 D nuclear chromosome segregation
APHEDCCB_01577 5.8e-225 proA 1.2.1.41 E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
APHEDCCB_01578 5.7e-141 proB 2.7.2.11 E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
APHEDCCB_01579 2.2e-285 XK27_00765
APHEDCCB_01580 8.1e-134 ecsA_2 V abc transporter atp-binding protein
APHEDCCB_01581 9.6e-111 S Protein of unknown function (DUF554)
APHEDCCB_01582 0.0 addA 3.6.4.12 L ATP-dependent helicase nuclease subunit A
APHEDCCB_01583 0.0 rexB 3.1.21.3, 3.6.4.12 L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
APHEDCCB_01584 9.8e-57 liaI S membrane
APHEDCCB_01585 7e-10 XK27_02470 K LytTr DNA-binding domain protein
APHEDCCB_01586 1.8e-65 KT response to antibiotic
APHEDCCB_01587 5.2e-81 yebC M Membrane
APHEDCCB_01588 2.9e-18 yebC M Membrane
APHEDCCB_01589 4.3e-261 XK27_03190 5.2.1.8 S hydrolases of the HAD superfamily
APHEDCCB_01590 9.4e-172 ansA 3.5.1.1 EJ COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D
APHEDCCB_01592 0.0 recG 3.6.4.12 L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APHEDCCB_01593 2.4e-182 alr 5.1.1.1, 5.1.1.5 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APHEDCCB_01594 4.1e-62 acpS 2.7.6.3, 2.7.8.7, 5.1.1.1 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
APHEDCCB_01595 1.1e-197 aroF 2.5.1.54 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APHEDCCB_01596 3.8e-198 aroF 2.5.1.54 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APHEDCCB_01597 0.0 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
APHEDCCB_01599 3e-189 manA 5.3.1.8 G mannose-6-phosphate isomerase
APHEDCCB_01600 1.2e-171 scrK 2.7.1.2, 2.7.1.4 GK Fructokinase
APHEDCCB_01601 0.0 scrA 2.7.1.208, 2.7.1.211 G pts system
APHEDCCB_01602 5.4e-291 scrB 3.2.1.26 GH32 G invertase
APHEDCCB_01603 7.5e-180 scrR K Transcriptional
APHEDCCB_01604 2.1e-73 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APHEDCCB_01605 3.4e-62 yqhY S protein conserved in bacteria
APHEDCCB_01606 1.2e-97 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APHEDCCB_01607 3.7e-84 comEB 3.5.4.12 F ComE operon protein 2
APHEDCCB_01608 5e-193 pepP 3.4.11.9, 3.4.13.9 E Belongs to the peptidase M24B family
APHEDCCB_01610 8e-44 V 'abc transporter, ATP-binding protein
APHEDCCB_01611 1e-58 V 'abc transporter, ATP-binding protein
APHEDCCB_01614 0.0 uvrA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APHEDCCB_01615 2e-169 corA P COG0598 Mg2 and Co2 transporters
APHEDCCB_01616 3.1e-124 XK27_01040 S Pfam PF06570
APHEDCCB_01618 9.7e-36 rpsR J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
APHEDCCB_01619 2.7e-91 ssb L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
APHEDCCB_01620 3.9e-47 rpsF J Binds together with S18 to 16S ribosomal RNA
APHEDCCB_01621 3.6e-41 XK27_05745
APHEDCCB_01622 2.5e-230 mutY L A G-specific adenine glycosylase
APHEDCCB_01628 0.0 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APHEDCCB_01629 0.0 mutS2 L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
APHEDCCB_01630 1e-93 cvpA S toxin biosynthetic process
APHEDCCB_01631 2.3e-13 zapA D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
APHEDCCB_01632 4.7e-160 rnhC 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APHEDCCB_01633 1.3e-113 lepB 3.4.21.89 U Belongs to the peptidase S26 family
APHEDCCB_01634 0.0 recD2 3.1.11.5 L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
APHEDCCB_01635 2e-47 azlD E branched-chain amino acid
APHEDCCB_01636 5.2e-114 azlC E AzlC protein
APHEDCCB_01637 1.1e-186 tsaD 2.3.1.234 O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
APHEDCCB_01638 8.2e-73 rimI 2.3.1.128 K This enzyme acetylates the N-terminal alanine of ribosomal protein S18
APHEDCCB_01639 5.6e-121 yeaZ 2.3.1.234 O COG1214, inactive homolog of metal-dependent proteases
APHEDCCB_01640 2.5e-33 ykzG S Belongs to the UPF0356 family
APHEDCCB_01641 0.0 rnjA S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
APHEDCCB_01642 2.7e-40 pscB M CHAP domain protein
APHEDCCB_01643 1.5e-263 glnA 6.3.1.2 E glutamine synthetase
APHEDCCB_01644 8.5e-63 glnR K Transcriptional regulator
APHEDCCB_01645 1.3e-87 S Fusaric acid resistance protein-like
APHEDCCB_01646 1.1e-12
APHEDCCB_01647 1e-30 L Helix-turn-helix domain of transposase family ISL3
APHEDCCB_01648 0.0 fusA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APHEDCCB_01649 6.7e-81 rpsG J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
APHEDCCB_01650 2.3e-69 rpsL J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
APHEDCCB_01651 1.1e-142 purR 2.4.2.7 F operon repressor
APHEDCCB_01652 3.6e-179 cbf S 3'-5' exoribonuclease yhaM
APHEDCCB_01653 6.9e-173 rmuC S RmuC domain protein
APHEDCCB_01654 3.1e-118 thiN 2.7.6.2 H thiamine pyrophosphokinase
APHEDCCB_01655 3e-119 rpe 5.1.3.1 G Belongs to the ribulose-phosphate 3-epimerase family
APHEDCCB_01656 6.4e-162 rsgA 3.1.3.100 G One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
APHEDCCB_01658 5.8e-155 ksgA 2.1.1.182 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
APHEDCCB_01659 1.1e-98 rnmV 3.1.26.8 J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
APHEDCCB_01660 1.6e-143 tatD L Hydrolase, tatd
APHEDCCB_01661 7.2e-74 yccU S CoA-binding protein
APHEDCCB_01662 4.8e-51 trxA O Belongs to the thioredoxin family
APHEDCCB_01663 1.9e-141 S Macro domain protein
APHEDCCB_01664 2e-09 L thioesterase
APHEDCCB_01665 2.2e-54 bta 1.8.1.8 CO cell redox homeostasis
APHEDCCB_01668 1.7e-226 tgt 2.4.2.29 F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
APHEDCCB_01669 1.5e-57 L Transposase
APHEDCCB_01670 1e-13 rpmH J Ribosomal protein L34
APHEDCCB_01671 2e-186 jag S RNA-binding protein
APHEDCCB_01672 7.5e-141 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
APHEDCCB_01673 5.9e-55 rnpA 3.1.26.5 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
APHEDCCB_01674 4.1e-264 argH 4.3.2.1 E Argininosuccinate lyase
APHEDCCB_01675 2e-230 argG 6.3.4.5 E Belongs to the argininosuccinate synthase family. Type 1 subfamily
APHEDCCB_01676 2.1e-282 gltX 6.1.1.17, 6.1.1.24 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APHEDCCB_01677 2.8e-79 amiA E transmembrane transport
APHEDCCB_01678 4.2e-74 amiA E transmembrane transport
APHEDCCB_01679 4.8e-120 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
APHEDCCB_01680 3.7e-70 rplK J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
APHEDCCB_01681 9.2e-51 S Protein of unknown function (DUF3397)
APHEDCCB_01682 2e-88 cah 4.2.1.1 P Reversible hydration of carbon dioxide
APHEDCCB_01683 9.3e-34 WQ51_05710 S Mitochondrial biogenesis AIM24
APHEDCCB_01684 6.8e-32 WQ51_05710 S Mitochondrial biogenesis AIM24
APHEDCCB_01685 6.2e-12 WQ51_05710 S Mitochondrial biogenesis AIM24
APHEDCCB_01686 1.7e-221 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
APHEDCCB_01687 5.4e-80 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
APHEDCCB_01688 4.7e-20 XK27_09620 S FMN reductase (NADPH) activity
APHEDCCB_01689 4.3e-77 XK27_09620 S reductase
APHEDCCB_01690 9e-62 XK27_09615 C reductase
APHEDCCB_01691 2.3e-141 XK27_09615 C reductase
APHEDCCB_01692 1.9e-07 fnt P Formate nitrite transporter
APHEDCCB_01693 2.9e-46 fnt P Formate nitrite transporter
APHEDCCB_01694 8.5e-33 fnt P Formate nitrite transporter
APHEDCCB_01695 7.2e-64 XK27_08585 S Psort location CytoplasmicMembrane, score
APHEDCCB_01696 6.3e-185 gpsA 1.1.1.94 I Glycerol-3-phosphate dehydrogenase
APHEDCCB_01697 1.8e-170 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
APHEDCCB_01698 2.8e-117 gluP 3.4.21.105 O membrane protein (homolog of Drosophila rhomboid)
APHEDCCB_01699 3.5e-94 ygfA 6.3.3.2 H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APHEDCCB_01700 3e-220 hipO 3.5.1.47 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
APHEDCCB_01701 8.1e-59 dapD 2.3.1.117, 2.3.1.89 E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
APHEDCCB_01702 5.3e-50 S glycolate biosynthetic process
APHEDCCB_01703 1.5e-64 S phosphatase activity
APHEDCCB_01704 5.4e-158 rrmA 2.1.1.187 Q methyltransferase
APHEDCCB_01707 2.7e-91 tadA 3.5.4.1, 3.5.4.33 FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
APHEDCCB_01708 1.9e-65 ssb_2 L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
APHEDCCB_01709 2.4e-36 yeeD O sulfur carrier activity
APHEDCCB_01710 1.8e-187 yeeE S Sulphur transport
APHEDCCB_01711 7.9e-114 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
APHEDCCB_01712 4.2e-55 ytpP 2.7.1.180, 5.3.4.1 CO Thioredoxin
APHEDCCB_01713 4.1e-09 S Domain of unknown function (DUF4651)
APHEDCCB_01714 2e-205 pepA 3.4.11.7 G COG1363 Cellulase M and related proteins
APHEDCCB_01715 3.9e-131 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
APHEDCCB_01716 1.8e-111 S CAAX amino terminal protease family protein
APHEDCCB_01718 8.4e-67 V CAAX protease self-immunity
APHEDCCB_01719 1.4e-33 V CAAX protease self-immunity
APHEDCCB_01720 8.8e-27 lanR K sequence-specific DNA binding
APHEDCCB_01721 2.9e-221 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
APHEDCCB_01722 5.9e-177 ytxK 2.1.1.72 L DNA methylase
APHEDCCB_01723 6.8e-13 comGF U Putative Competence protein ComGF
APHEDCCB_01724 4e-72 comGF U Competence protein ComGF
APHEDCCB_01725 1.4e-15 NU Type II secretory pathway pseudopilin
APHEDCCB_01726 1.8e-57 cglD NU Competence protein
APHEDCCB_01727 9.4e-42 comGC U Required for transformation and DNA binding
APHEDCCB_01728 1.1e-156 cglB U protein transport across the cell outer membrane
APHEDCCB_01729 1.9e-175 comGA NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APHEDCCB_01730 2.9e-68 S cog cog4699
APHEDCCB_01731 0.0 rpoC 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APHEDCCB_01732 0.0 rpoB 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APHEDCCB_01733 0.0 pbp1B 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
APHEDCCB_01734 1.2e-238 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
APHEDCCB_01735 1.6e-196 ilvC 1.1.1.86 H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
APHEDCCB_01736 7.7e-77 ilvN 2.2.1.6 E Acetolactate synthase
APHEDCCB_01737 0.0 ilvB 2.2.1.6 EH Acetolactate synthase
APHEDCCB_01738 3e-248 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
APHEDCCB_01739 3.1e-47 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
APHEDCCB_01740 2.2e-304 yloV S kinase related to dihydroxyacetone kinase
APHEDCCB_01741 1.4e-57 asp S cog cog1302
APHEDCCB_01742 9.3e-226 norN V Mate efflux family protein
APHEDCCB_01743 2.4e-278 thrC 4.2.3.1 E Threonine synthase
APHEDCCB_01744 5.5e-65 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
APHEDCCB_01745 8e-35 adhE 1.1.1.1, 1.2.1.10 C hydroxyacid-oxoacid transhydrogenase activity
APHEDCCB_01746 1.5e-74 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
APHEDCCB_01747 1.3e-135 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
APHEDCCB_01748 1.4e-63 adhE 1.1.1.1, 1.2.1.10 C Dehydrogenase
APHEDCCB_01749 0.0 pepO 3.4.24.71 O Peptidase family M13
APHEDCCB_01750 2.8e-38 treC 3.2.1.93 GH13 G COG0366 Glycosidases
APHEDCCB_01751 1.2e-69 treC 3.2.1.93 GH13 G COG0366 Glycosidases
APHEDCCB_01752 5.9e-66 treC 3.2.1.93 GH13 G COG0366 Glycosidases
APHEDCCB_01753 1.4e-54 treB 2.7.1.201 G PTS System
APHEDCCB_01754 5.8e-21 treR K DNA-binding transcription factor activity
APHEDCCB_01755 1.2e-85 treR K trehalose operon
APHEDCCB_01756 3.3e-95 ywlG S Belongs to the UPF0340 family
APHEDCCB_01759 8.2e-89 L PFAM Integrase, catalytic core
APHEDCCB_01760 3.3e-46 K Putative DNA-binding domain
APHEDCCB_01761 2.5e-13 2.3.1.82 M Acetyltransferase GNAT Family
APHEDCCB_01762 1.2e-126 gltT C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
APHEDCCB_01763 6.4e-136 HJ the current gene model (or a revised gene model) may contain a frame shift
APHEDCCB_01768 1e-39
APHEDCCB_01769 1.1e-30
APHEDCCB_01770 5e-31 S Hypothetical protein (DUF2513)
APHEDCCB_01771 7.7e-13
APHEDCCB_01773 5.7e-217 S MvaI/BcnI restriction endonuclease family
APHEDCCB_01775 2.2e-282 dcm 2.1.1.37 H C-5 cytosine-specific DNA methylase
APHEDCCB_01776 9e-164 fba 4.1.2.13, 4.1.2.29 G aldolase
APHEDCCB_01778 6.7e-110 6.3.2.2 H ergothioneine biosynthetic process
APHEDCCB_01779 1.5e-65 6.3.2.2 H gamma-glutamylcysteine synthetase
APHEDCCB_01780 2.5e-12 6.3.2.2 H gamma-glutamylcysteine synthetase
APHEDCCB_01781 3.3e-09 L PFAM Integrase, catalytic core
APHEDCCB_01782 3.3e-62 rplQ J ribosomal protein l17
APHEDCCB_01783 4.8e-171 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APHEDCCB_01784 9.6e-62 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APHEDCCB_01785 4e-57 rpsM J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APHEDCCB_01786 6e-15 rpmJ J Belongs to the bacterial ribosomal protein bL36 family
APHEDCCB_01787 2.7e-32 infA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
APHEDCCB_01788 9.2e-121 adk 2.7.4.3 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
APHEDCCB_01789 9.6e-231 secY U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
APHEDCCB_01790 4.4e-58 rplO J binds to the 23S rRNA
APHEDCCB_01791 2.5e-23 rpmD J ribosomal protein l30
APHEDCCB_01792 1.7e-79 rpsE J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
APHEDCCB_01793 1.9e-56 rplR J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
APHEDCCB_01794 2.3e-93 rplF J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
APHEDCCB_01795 1.2e-67 rpsH J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
APHEDCCB_01796 1.5e-28 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APHEDCCB_01797 1.6e-94 rplE J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APHEDCCB_01798 1.4e-47 rplX J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
APHEDCCB_01799 1.1e-59 rplN J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
APHEDCCB_01800 6e-39 rpsQ J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
APHEDCCB_01801 2.7e-26 rpmC J Belongs to the universal ribosomal protein uL29 family
APHEDCCB_01802 7.2e-71 rplP J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
APHEDCCB_01803 2.1e-117 rpsC J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
APHEDCCB_01804 7.3e-53 rplV J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
APHEDCCB_01805 4.9e-47 rpsS J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
APHEDCCB_01806 8.8e-153 rplB J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
APHEDCCB_01807 2.4e-44 rplW J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
APHEDCCB_01808 5.7e-104 rplD J Forms part of the polypeptide exit tunnel
APHEDCCB_01809 1.1e-110 rplC J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
APHEDCCB_01810 1.3e-48 rpsJ J Involved in the binding of tRNA to the ribosomes
APHEDCCB_01811 7.8e-188 ruvB 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
APHEDCCB_01812 0.0 XK27_09800 I Acyltransferase
APHEDCCB_01813 1.7e-35 XK27_09805 S MORN repeat protein
APHEDCCB_01814 1e-80 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
APHEDCCB_01815 4.1e-250 purA 6.3.4.4 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
APHEDCCB_01816 1.5e-89 adk 2.7.4.3 F topology modulation protein
APHEDCCB_01817 2.7e-12 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
APHEDCCB_01818 2.8e-128 Z012_04635 K sequence-specific DNA binding
APHEDCCB_01820 6.3e-16 C Radical SAM
APHEDCCB_01821 3.4e-191 C Radical SAM
APHEDCCB_01822 3.9e-287 V ABC transporter transmembrane region
APHEDCCB_01823 2.5e-89 K sequence-specific DNA binding
APHEDCCB_01824 2.9e-07 L Replication initiation factor
APHEDCCB_01825 1.4e-107 L Replication initiation factor
APHEDCCB_01826 1.9e-18 S Domain of unknown function (DUF3173)
APHEDCCB_01827 3.5e-216 int L Belongs to the 'phage' integrase family
APHEDCCB_01829 5.2e-237 rarA L ATPase related to the helicase subunit of the Holliday junction resolvase
APHEDCCB_01830 8.4e-27 rpmB J Belongs to the bacterial ribosomal protein bL28 family
APHEDCCB_01831 2.8e-44 yrzL S Belongs to the UPF0297 family
APHEDCCB_01832 1.2e-70 yqgF L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
APHEDCCB_01833 4.2e-44 yrzB S Belongs to the UPF0473 family
APHEDCCB_01834 1.1e-300 ccs S the current gene model (or a revised gene model) may contain a frame shift
APHEDCCB_01835 0.0 nrdD 1.1.98.6 F Ribonucleoside-triphosphate reductase
APHEDCCB_01836 7.5e-14
APHEDCCB_01837 2.6e-91 XK27_10930 K acetyltransferase
APHEDCCB_01838 3.7e-116 nrdG 1.97.1.4 O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APHEDCCB_01839 1.8e-147 yaaA S Belongs to the UPF0246 family
APHEDCCB_01840 9.9e-169 XK27_01785 S cog cog1284
APHEDCCB_01841 0.0 aspS 6.1.1.12 J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
APHEDCCB_01843 1.6e-241 hisS 6.1.1.21 J histidyl-tRNA synthetase
APHEDCCB_01844 5.7e-52 metE 2.1.1.14 E Methionine synthase
APHEDCCB_01845 7.6e-64 metE 2.1.1.14 E Methionine synthase
APHEDCCB_01846 9.2e-36 metE 2.1.1.14 E Methionine synthase
APHEDCCB_01847 2e-25 rpmF J Belongs to the bacterial ribosomal protein bL32 family
APHEDCCB_01848 6.7e-19 rpmG J Belongs to the bacterial ribosomal protein bL33 family
APHEDCCB_01850 3.1e-20 yegS 2.7.1.107 I lipid kinase activity
APHEDCCB_01851 2.7e-95 S Hydrophobic domain protein
APHEDCCB_01853 3.7e-27 S Membrane
APHEDCCB_01854 3.1e-101
APHEDCCB_01855 1.8e-23 S Small integral membrane protein
APHEDCCB_01856 1.1e-71 M Protein conserved in bacteria
APHEDCCB_01857 4.9e-12 K CsbD-like
APHEDCCB_01858 3.5e-97 nudL L hydrolase
APHEDCCB_01859 3.4e-13 nudL L hydrolase
APHEDCCB_01860 4e-19 K negative regulation of transcription, DNA-templated
APHEDCCB_01861 1.7e-23 K negative regulation of transcription, DNA-templated
APHEDCCB_01863 1.8e-19 XK27_06920 S Protein of unknown function (DUF1700)
APHEDCCB_01864 1.5e-73 S Putative adhesin
APHEDCCB_01865 3.9e-161 XK27_06930 V domain protein
APHEDCCB_01866 6.4e-96 XK27_06935 K transcriptional regulator
APHEDCCB_01867 4.8e-55 ypaA M Membrane
APHEDCCB_01868 2.7e-08
APHEDCCB_01871 4.4e-18 yjgN S membrane
APHEDCCB_01872 2.8e-27 S Transcriptional regulator, RinA family
APHEDCCB_01878 6.5e-266
APHEDCCB_01879 3.8e-13
APHEDCCB_01880 6.7e-17
APHEDCCB_01881 3.4e-12 K Helix-turn-helix
APHEDCCB_01882 1.4e-12 K sequence-specific DNA binding
APHEDCCB_01883 6.4e-141 sip L Phage integrase, N-terminal SAM-like domain
APHEDCCB_01884 2.9e-108 rpsD J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
APHEDCCB_01885 8.2e-48 veg S Biofilm formation stimulator VEG
APHEDCCB_01886 1.5e-245 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
APHEDCCB_01887 3.9e-70 rplI J binds to the 23S rRNA
APHEDCCB_01888 0.0 yybT T signaling protein consisting of a modified GGDEF domain and a DHH domain
APHEDCCB_01889 0.0 gidA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
APHEDCCB_01890 2.1e-218 mnmA 2.8.1.13 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
APHEDCCB_01891 0.0 S Bacterial membrane protein, YfhO
APHEDCCB_01892 1.5e-88 isaA GH23 M Immunodominant staphylococcal antigen A
APHEDCCB_01893 5.3e-85 lytE M LysM domain protein
APHEDCCB_01894 2e-138 ecfT P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
APHEDCCB_01895 5.2e-153 ecfA2 3.6.3.55 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
APHEDCCB_01896 1.5e-152 ecfA1 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
APHEDCCB_01897 3.1e-90 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
APHEDCCB_01898 6.3e-138 ymfM S sequence-specific DNA binding
APHEDCCB_01899 3.2e-92 ymfH S Peptidase M16
APHEDCCB_01900 1e-99 ymfH S Peptidase M16
APHEDCCB_01901 4.8e-235 ymfF S Peptidase M16
APHEDCCB_01902 1.6e-45 yaaA S S4 domain protein YaaA
APHEDCCB_01903 5.9e-205 recF L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APHEDCCB_01904 4.3e-275 guaB 1.1.1.205 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
APHEDCCB_01905 6.3e-193 trpS 6.1.1.2 J Tryptophanyl-tRNA synthetase
APHEDCCB_01906 4.2e-153 yvjA S membrane
APHEDCCB_01907 6.7e-306 ybiT S abc transporter atp-binding protein
APHEDCCB_01908 0.0 XK27_10405 S Bacterial membrane protein YfhO
APHEDCCB_01912 6.2e-120 yoaK S Psort location CytoplasmicMembrane, score
APHEDCCB_01913 1.1e-86 rlmH 2.1.1.177 J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
APHEDCCB_01914 5.3e-194 htrA 3.4.21.107 O Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain'
APHEDCCB_01915 8.5e-134 parB K Belongs to the ParB family
APHEDCCB_01916 1.8e-245 L Transposase
APHEDCCB_01917 9.4e-43 K Cold-Shock Protein

eggNOG-mapper v2 (Database: eggNOG v5.0, Jul. 2018 release)