ORF_ID e_value Gene_name EC_number CAZy COGs Description
APGEEAHD_00001 3.7e-44 L Transposase
APGEEAHD_00003 0.0 copB 3.6.3.4 P E1-E2 ATPase
APGEEAHD_00004 1.7e-60 hmpT S membrane
APGEEAHD_00005 6.2e-137 thiD 2.7.1.35, 2.7.1.49, 2.7.4.7 H phosphomethylpyrimidine kinase
APGEEAHD_00006 2.5e-138 truA 5.4.99.12 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
APGEEAHD_00007 4.2e-190 dnaJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
APGEEAHD_00008 9.8e-298 dnaK O Heat shock 70 kDa protein
APGEEAHD_00009 5.3e-70 grpE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
APGEEAHD_00010 5.3e-198 hrcA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
APGEEAHD_00011 1.5e-101 acmA 3.2.1.17 NU amidase activity
APGEEAHD_00012 7.9e-143 vanY 3.4.17.14 M D-alanyl-D-alanine carboxypeptidase
APGEEAHD_00013 5.4e-135 ais G Phosphoglycerate mutase
APGEEAHD_00014 8.7e-243 XK27_08635 S UPF0210 protein
APGEEAHD_00015 6.1e-39 gcvR T UPF0237 protein
APGEEAHD_00016 8.2e-224 capA M Bacterial capsule synthesis protein
APGEEAHD_00017 2.4e-124 tnp L Transposase IS66 family
APGEEAHD_00018 5.5e-65 dhaL 2.7.1.121 G Dihydroxyacetone kinase
APGEEAHD_00019 3.3e-247 G polysaccharide deacetylase
APGEEAHD_00020 5.9e-88 tnp L Transposase
APGEEAHD_00021 3.4e-75 isp2 S pathogenesis
APGEEAHD_00023 4.9e-173
APGEEAHD_00024 1.8e-38 S Helix-turn-helix domain
APGEEAHD_00025 7.4e-225 int L Belongs to the 'phage' integrase family
APGEEAHD_00026 5.9e-91 3.6.4.12 K Divergent AAA domain protein
APGEEAHD_00027 5.9e-24 3.6.4.12
APGEEAHD_00028 4.3e-183 EGP Major facilitator Superfamily
APGEEAHD_00029 2.4e-231 spaC2 V Lanthionine synthetase C family protein
APGEEAHD_00030 3.3e-217 S Lantibiotic dehydratase, C terminus
APGEEAHD_00031 8.2e-205 S Lantibiotic dehydratase, C terminus
APGEEAHD_00033 1.5e-35 K sequence-specific DNA binding
APGEEAHD_00034 9.5e-65 rpsI J Belongs to the universal ribosomal protein uS9 family
APGEEAHD_00035 2e-79 rplM J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
APGEEAHD_00036 1.6e-182 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
APGEEAHD_00037 2.3e-31 K helix-turn-helix
APGEEAHD_00038 3.4e-155 degV S DegV family
APGEEAHD_00039 1e-84 yacP S RNA-binding protein containing a PIN domain
APGEEAHD_00040 5.7e-135 trmH 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APGEEAHD_00043 4.2e-68 mrnC J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
APGEEAHD_00044 1.7e-259 cysS 6.1.1.16, 6.3.1.13 J Belongs to the class-I aminoacyl-tRNA synthetase family
APGEEAHD_00045 1.1e-112 cysE 2.3.1.30 E serine acetyltransferase
APGEEAHD_00046 6.9e-144 S SseB protein N-terminal domain
APGEEAHD_00047 0.0 pnp 2.7.7.8 J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
APGEEAHD_00048 1.4e-231 dacA 3.4.16.4 M Belongs to the peptidase S11 family
APGEEAHD_00049 1.8e-32 dacA 3.4.16.4 M Belongs to the peptidase S11 family
APGEEAHD_00050 3.2e-151 dacA 3.4.16.4 M Belongs to the peptidase S11 family
APGEEAHD_00051 0.0 clpC O Belongs to the ClpA ClpB family
APGEEAHD_00052 6.2e-76 ctsR K Belongs to the CtsR family
APGEEAHD_00053 5.5e-83 S Putative small multi-drug export protein
APGEEAHD_00054 1.7e-182 tsf J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
APGEEAHD_00055 1.6e-137 rpsB J Belongs to the universal ribosomal protein uS2 family
APGEEAHD_00057 4.6e-91 yocD 3.4.17.13 V proteins, homologs of microcin C7 resistance protein MccF
APGEEAHD_00058 4.2e-77 yocD 3.4.17.13 V carboxypeptidase activity
APGEEAHD_00059 6.4e-41 L transposition
APGEEAHD_00060 6.9e-89 L Integrase core domain protein
APGEEAHD_00061 3.5e-97 S reductase
APGEEAHD_00062 2.6e-55 badR K DNA-binding transcription factor activity
APGEEAHD_00063 5.5e-36 XK27_02060 S Transglycosylase associated protein
APGEEAHD_00064 1.2e-235 pepS E COG2309 Leucyl aminopeptidase (aminopeptidase T)
APGEEAHD_00065 0.0 polC 2.7.7.7 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APGEEAHD_00070 1.9e-07
APGEEAHD_00073 2.6e-10
APGEEAHD_00078 0.0 amiA E ABC transporter, substrate-binding protein, family 5
APGEEAHD_00079 1.2e-24 oppF P Belongs to the ABC transporter superfamily
APGEEAHD_00080 3.8e-45 oppF P Belongs to the ABC transporter superfamily
APGEEAHD_00081 1.4e-40 tatD L Hydrolase, tatd
APGEEAHD_00082 6.7e-218 oxlT P COG0477 Permeases of the major facilitator superfamily
APGEEAHD_00083 1e-110 L Integrase core domain protein
APGEEAHD_00084 1.1e-23 L transposase activity
APGEEAHD_00085 8.2e-38 L transposase activity
APGEEAHD_00086 1.4e-181 pta 2.3.1.8, 3.6.3.21 C phosphate acetyltransferase
APGEEAHD_00087 2.8e-173 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 J Responsible for synthesis of pseudouridine from uracil
APGEEAHD_00088 5.4e-150 nadK 2.7.1.23 H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
APGEEAHD_00089 5.5e-121 yjbM 2.7.6.5 S Gtp pyrophosphokinase
APGEEAHD_00090 1.5e-103 yjbK S Adenylate cyclase
APGEEAHD_00091 2.1e-177 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APGEEAHD_00092 7e-206 iscS 2.8.1.7 E Cysteine desulfurase
APGEEAHD_00093 2e-58 XK27_04120 S Putative amino acid metabolism
APGEEAHD_00094 8.2e-117 rex K Modulates transcription in response to changes in cellular NADH NAD( ) redox state
APGEEAHD_00095 1.6e-131 puuD T peptidase C26
APGEEAHD_00096 2.4e-119 radC E Belongs to the UPF0758 family
APGEEAHD_00097 1.6e-270 rgpF M Rhamnan synthesis protein F
APGEEAHD_00098 9.9e-222 rgpD 3.6.3.38 P Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system
APGEEAHD_00099 3.7e-140 rgpC GM Transport permease protein
APGEEAHD_00100 2.4e-170 rgpB GT2 M Glycosyltransferase, group 2 family protein
APGEEAHD_00101 9.5e-222 rgpA GT4 M Domain of unknown function (DUF1972)
APGEEAHD_00102 1.2e-253 S Glucosyl transferase GtrII
APGEEAHD_00103 2.1e-219 GT4 M transferase activity, transferring glycosyl groups
APGEEAHD_00104 1.1e-226 M Psort location CytoplasmicMembrane, score
APGEEAHD_00105 0.0 rgpF GT2,GT4 M Glycosyltransferase like family 2
APGEEAHD_00106 5.5e-149 2.4.1.60 S Glycosyltransferase group 2 family protein
APGEEAHD_00107 4.6e-42 S Uncharacterized conserved protein (DUF2304)
APGEEAHD_00108 4.5e-129 arnC M group 2 family protein
APGEEAHD_00109 9.5e-183 cpsIaJ S Glycosyltransferase like family 2
APGEEAHD_00110 6e-185 S Glycosyltransferase like family 2
APGEEAHD_00111 4.8e-219 amrA S membrane protein involved in the export of O-antigen and teichoic acid
APGEEAHD_00112 3.8e-159 rfbD 1.1.1.133, 5.1.3.13 M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
APGEEAHD_00113 1.1e-213 S Predicted membrane protein (DUF2142)
APGEEAHD_00114 2.4e-167 yfdH GT2 M COG0463, glycosyltransferases involved in cell wall biogenesis
APGEEAHD_00115 3.4e-55 yitW K metal-sulfur cluster biosynthetic enzyme
APGEEAHD_00116 1.1e-201 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
APGEEAHD_00117 0.0 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
APGEEAHD_00118 5.5e-20 rpsU J Belongs to the bacterial ribosomal protein bS21 family
APGEEAHD_00119 1.1e-136 gltS ET Belongs to the bacterial solute-binding protein 3 family
APGEEAHD_00120 1.4e-201 arcT 2.6.1.1 E Aminotransferase
APGEEAHD_00121 2.5e-136 ET ABC transporter
APGEEAHD_00122 2.8e-143 ET Belongs to the bacterial solute-binding protein 3 family
APGEEAHD_00123 2.9e-84 mutT 3.6.1.55 F Nudix family
APGEEAHD_00124 0.0 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
APGEEAHD_00126 9.9e-87 S CAAX amino terminal protease family protein
APGEEAHD_00127 2.4e-33 S CAAX amino terminal protease family protein
APGEEAHD_00128 0.0 glnP P ABC-type amino acid transport signal transduction systems periplasmic component domain
APGEEAHD_00129 1e-136 glnQ 3.6.3.21 E abc transporter atp-binding protein
APGEEAHD_00130 1.1e-16 XK27_00735
APGEEAHD_00131 1.4e-248 obg S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
APGEEAHD_00133 7.3e-135 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
APGEEAHD_00136 5.5e-65 paaI Q protein possibly involved in aromatic compounds catabolism
APGEEAHD_00137 3e-37 ycaO O OsmC-like protein
APGEEAHD_00139 3.2e-153 EG Permeases of the drug metabolite transporter (DMT) superfamily
APGEEAHD_00141 9.7e-115 serB 3.1.3.3 E phosphoserine phosphatase
APGEEAHD_00142 2.9e-299 ezrA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
APGEEAHD_00143 0.0 gyrB 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APGEEAHD_00144 2.6e-109 3.1.3.18 S IA, variant 1
APGEEAHD_00145 2.2e-117 lrgB M effector of murein hydrolase
APGEEAHD_00146 1.7e-55 lrgA S Effector of murein hydrolase LrgA
APGEEAHD_00148 6.4e-60 arsC 1.20.4.1 P Belongs to the ArsC family
APGEEAHD_00149 3.1e-56 ogt 2.1.1.63, 3.2.2.20 L methylated-DNA-[protein]-cysteine S-methyltransferase activity
APGEEAHD_00150 7e-220 serA 1.1.1.399, 1.1.1.95 EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APGEEAHD_00151 3.9e-104 wecD M Acetyltransferase GNAT family
APGEEAHD_00152 1.3e-209 serC 2.6.1.52 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
APGEEAHD_00153 5.1e-96 GK ROK family
APGEEAHD_00154 8.1e-72 gloA 4.4.1.5 E Lactoylglutathione lyase
APGEEAHD_00155 1.7e-47 XK27_08050 O stress-induced mitochondrial fusion
APGEEAHD_00156 1.3e-19 XK27_08050 O HflC and HflK could regulate a protease
APGEEAHD_00157 2.3e-206 potD P spermidine putrescine ABC transporter
APGEEAHD_00158 3e-134 potC P ABC-type spermidine putrescine transport system, permease component II
APGEEAHD_00159 3.7e-140 potB P ABC-type spermidine putrescine transport system, permease component I
APGEEAHD_00160 1.1e-212 potA 3.6.3.30, 3.6.3.31 P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
APGEEAHD_00161 7.8e-171 murB 1.3.1.98 M cell wall formation
APGEEAHD_00162 2.9e-87 folK 2.7.6.3, 4.1.2.25 H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
APGEEAHD_00163 1.2e-61 folB 1.13.11.81, 2.5.1.15, 2.7.6.3, 4.1.2.25, 5.1.99.8 H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
APGEEAHD_00164 1.2e-298 amy 3.2.1.1 GH13 G Belongs to the glycosyl hydrolase 13 family
APGEEAHD_00165 7e-147 folP 2.5.1.15, 2.7.6.3 H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
APGEEAHD_00166 1e-99 folE 3.5.4.16 F gtp cyclohydrolase
APGEEAHD_00167 0.0 ydaO E amino acid
APGEEAHD_00168 5.5e-239 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
APGEEAHD_00169 4.1e-37 ylqC L Belongs to the UPF0109 family
APGEEAHD_00170 2.4e-43 rpsP J Belongs to the bacterial ribosomal protein bS16 family
APGEEAHD_00171 2e-171 tehB 2.1.1.265 PQ tellurite resistance protein tehb
APGEEAHD_00172 8.2e-159 xth 3.1.11.2 L exodeoxyribonuclease III
APGEEAHD_00173 4.7e-74 S QueT transporter
APGEEAHD_00174 1.9e-55 L Transposase
APGEEAHD_00175 5.7e-186 yegS 2.7.1.107 I Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
APGEEAHD_00176 0.0 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APGEEAHD_00177 3.7e-85 ccl S cog cog4708
APGEEAHD_00178 7.4e-164 rbn E Belongs to the UPF0761 family
APGEEAHD_00179 5.5e-166 map 3.4.11.18 E Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed
APGEEAHD_00180 3.3e-231 ytoI K transcriptional regulator containing CBS domains
APGEEAHD_00181 2.4e-98 XK27_07830 2.3.1.128 J Acetyltransferase GNAT Family
APGEEAHD_00182 1e-232 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APGEEAHD_00183 0.0 comEC S Competence protein ComEC
APGEEAHD_00184 2.2e-96 comEA L COG1555 DNA uptake protein and related DNA-binding proteins
APGEEAHD_00185 3.7e-142 plsC 2.3.1.51 I Acyltransferase
APGEEAHD_00186 1.7e-77 nodB3 G polysaccharide deacetylase
APGEEAHD_00187 4.1e-22 nodB3 G polysaccharide deacetylase
APGEEAHD_00188 2.3e-139 yabB 2.1.1.223 L Methyltransferase
APGEEAHD_00189 1e-41 yazA L endonuclease containing a URI domain
APGEEAHD_00190 3.2e-252 cshA 3.6.4.13 JKL DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
APGEEAHD_00191 2.3e-154 corA P CorA-like protein
APGEEAHD_00192 1.9e-62 yjqA S Bacterial PH domain
APGEEAHD_00193 7.8e-100 thiT S Thiamine transporter
APGEEAHD_00194 2.1e-157 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
APGEEAHD_00195 1.9e-201 yjbB G Permeases of the major facilitator superfamily
APGEEAHD_00196 3.1e-300 prfC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
APGEEAHD_00197 1.4e-121 ywaF S Integral membrane protein (intg_mem_TP0381)
APGEEAHD_00198 1.5e-258 murF 6.3.2.10 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
APGEEAHD_00202 1.1e-155 cjaA ET ABC transporter substrate-binding protein
APGEEAHD_00203 7.6e-135 glnQ 3.6.3.21 E abc transporter atp-binding protein
APGEEAHD_00204 1e-114 P ABC transporter (Permease
APGEEAHD_00205 1e-114 papP P ABC transporter (Permease
APGEEAHD_00206 1.2e-191 ddl 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
APGEEAHD_00207 4.7e-31 copZ 2.7.7.77 P Heavy metal-associated domain protein
APGEEAHD_00208 0.0 copA 3.6.3.54 P P-type ATPase
APGEEAHD_00209 2.7e-73 copY K Copper transport repressor, CopY TcrY family
APGEEAHD_00210 2.1e-143 trpA 4.2.1.20 E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
APGEEAHD_00211 1.1e-228 trpB 4.2.1.20, 5.3.1.24 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
APGEEAHD_00212 3.3e-98 trpF 4.1.1.48, 4.2.1.160, 4.2.1.20, 5.3.1.24 E belongs to the TrpF family
APGEEAHD_00213 8.5e-134 trpC 4.1.1.48, 5.3.1.24 E Belongs to the TrpC family
APGEEAHD_00214 7.8e-180 trpD 2.4.2.18, 4.1.3.27 F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APGEEAHD_00215 3.6e-105 trpG 2.4.2.18, 2.6.1.85, 4.1.3.27 EH anthranilate
APGEEAHD_00216 2.2e-257 trpE 4.1.3.27 EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APGEEAHD_00217 2.6e-40 pchB 2.5.1.19, 4.2.1.10, 4.2.99.21, 5.4.99.5 E Chorismate mutase
APGEEAHD_00218 5.4e-53
APGEEAHD_00219 0.0 ctpE P E1-E2 ATPase
APGEEAHD_00220 2.7e-25
APGEEAHD_00221 1.2e-43 yaaK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
APGEEAHD_00222 9.7e-28 L transposase activity
APGEEAHD_00223 2.7e-129 K transcriptional regulator, MerR family
APGEEAHD_00224 1.4e-104 dnaQ 2.7.7.7 L DNA polymerase III
APGEEAHD_00225 1.2e-41 WQ51_02910 S Protein of unknown function, DUF536
APGEEAHD_00226 7.4e-64 XK27_02560 S cog cog2151
APGEEAHD_00227 0.0 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
APGEEAHD_00228 7.7e-227 ytfP S Flavoprotein
APGEEAHD_00230 3.1e-121 trmB 2.1.1.297, 2.1.1.33 J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
APGEEAHD_00231 1.2e-151 ytmP 2.7.1.89 M Phosphotransferase
APGEEAHD_00232 2.7e-183 ecsB U ABC transporter
APGEEAHD_00233 2.3e-133 ecsA V abc transporter atp-binding protein
APGEEAHD_00234 3.9e-72 hit FG Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
APGEEAHD_00235 2.3e-10
APGEEAHD_00236 2.7e-57 S CD20-like family
APGEEAHD_00237 4.7e-106
APGEEAHD_00238 0.0 clpL O ATP-dependent Clp protease ATP-binding subunit
APGEEAHD_00239 6.9e-206 ylbM S Belongs to the UPF0348 family
APGEEAHD_00240 2e-140 yqeM Q Methyltransferase domain protein
APGEEAHD_00241 6e-58 rsfS J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
APGEEAHD_00242 1.4e-107 nadD 2.7.6.3, 2.7.7.18 H HD superfamily hydrolase involved in NAD metabolism
APGEEAHD_00243 3.1e-118 nadD 2.7.7.18, 3.6.1.55 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
APGEEAHD_00244 3.5e-49 yhbY J RNA-binding protein
APGEEAHD_00245 1.7e-215 yqeH S in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis
APGEEAHD_00246 1.8e-98 yqeG S hydrolase of the HAD superfamily
APGEEAHD_00247 3.7e-152 yicL EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
APGEEAHD_00248 1.2e-58
APGEEAHD_00249 7.8e-274 gatB 6.1.1.12, 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APGEEAHD_00250 3.5e-269 gatA 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
APGEEAHD_00251 1.4e-47 gatC 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APGEEAHD_00252 6.3e-31 M lipopolysaccharide 3-alpha-galactosyltransferase activity
APGEEAHD_00253 1e-148 ascB 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
APGEEAHD_00254 5.1e-77 ascB 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
APGEEAHD_00255 3.6e-96 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APGEEAHD_00256 3.7e-154 hlpA M Belongs to the NlpA lipoprotein family
APGEEAHD_00257 6.8e-101 pncA Q isochorismatase
APGEEAHD_00258 1.2e-140 codY K DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
APGEEAHD_00259 3.7e-240 alaA 2.6.1.2, 2.6.1.66 E Aminotransferase
APGEEAHD_00260 2.4e-75 XK27_03180 T universal stress protein
APGEEAHD_00263 6.3e-156 pflA 1.97.1.4 C Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APGEEAHD_00264 7.6e-239 hlyX S COG1253 Hemolysins and related proteins containing CBS domains
APGEEAHD_00265 2.4e-144 modF 3.6.3.21, 3.6.3.34 P abc transporter atp-binding protein
APGEEAHD_00266 0.0 yjcE P NhaP-type Na H and K H antiporters
APGEEAHD_00268 1.4e-98 ytqB 2.1.1.176 J (SAM)-dependent
APGEEAHD_00269 1.3e-184 yhcC S radical SAM protein
APGEEAHD_00270 1.9e-195 ylbL T Belongs to the peptidase S16 family
APGEEAHD_00271 3e-87 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
APGEEAHD_00272 5.1e-93 rsmD 2.1.1.171 L Methyltransferase
APGEEAHD_00273 1.9e-172 trxB 1.8.1.9 C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
APGEEAHD_00274 1.9e-09 S Protein of unknown function (DUF4059)
APGEEAHD_00275 3.6e-129 tcyN 3.6.3.21 E abc transporter atp-binding protein
APGEEAHD_00276 8.6e-157 yxeN P ABC transporter (Permease
APGEEAHD_00277 7.7e-141 yxeM ET ABC-type amino acid transport signal transduction systems, periplasmic component domain
APGEEAHD_00278 2.4e-36 L transposition
APGEEAHD_00279 9.1e-86 L integrase core domain
APGEEAHD_00280 1.4e-104 yfiF3 K sequence-specific DNA binding
APGEEAHD_00281 9.8e-35 3.1.3.6, 3.1.4.16 F nucleotide catabolic process
APGEEAHD_00282 1.2e-112 sasH 3.1.3.5, 3.6.1.45 F Belongs to the 5'-nucleotidase family
APGEEAHD_00284 1.8e-67 yecS P ABC transporter (Permease
APGEEAHD_00285 2.6e-133 yckB ET Belongs to the bacterial solute-binding protein 3 family
APGEEAHD_00286 1e-103 nylA 3.5.1.4 J Belongs to the amidase family
APGEEAHD_00287 1.9e-267 dtpT E transporter
APGEEAHD_00289 1.2e-63 nylA 3.5.1.4 J Belongs to the amidase family
APGEEAHD_00290 7.5e-112 pyrE 2.4.2.10, 4.1.1.23 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APGEEAHD_00291 7e-127 pyrF 4.1.1.23 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
APGEEAHD_00292 5.2e-74 csm6 S Psort location Cytoplasmic, score
APGEEAHD_00293 2.1e-14 csm6 S Psort location Cytoplasmic, score
APGEEAHD_00294 4.4e-205 csm5 L CRISPR-associated RAMP protein, Csm5 family
APGEEAHD_00295 1.3e-165 csm4 L CRISPR-associated RAMP protein, Csm4 family
APGEEAHD_00296 1.1e-116 csm3 L RAMP superfamily
APGEEAHD_00297 5.6e-62 csm2 L Pfam:DUF310
APGEEAHD_00298 0.0 csm1 S CRISPR-associated protein Csm1 family
APGEEAHD_00299 6.8e-133 cas6 S Pfam:DUF2276
APGEEAHD_00300 3.7e-54 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
APGEEAHD_00301 1.2e-180 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
APGEEAHD_00302 4.2e-175 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
APGEEAHD_00303 1.3e-148 pyrK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )
APGEEAHD_00304 3.2e-95 thiJ 2.7.11.1, 3.5.1.124 S DJ-1 family
APGEEAHD_00305 1.3e-117 S TraX protein
APGEEAHD_00307 7.5e-214 ugd 1.1.1.22 M UDP binding domain
APGEEAHD_00308 1.7e-202 nodC 2.4.1.212 GT2 M Chitin synthase
APGEEAHD_00309 1.6e-249 L Transposase
APGEEAHD_00312 4.7e-68 S MucBP domain
APGEEAHD_00313 5.1e-14 S MucBP domain
APGEEAHD_00314 2.6e-51 M YSIRK type signal peptide
APGEEAHD_00315 2.3e-16 M the current gene model (or a revised gene model) may contain a
APGEEAHD_00316 0.0 M domain protein
APGEEAHD_00317 9.8e-32 L Integrase core domain protein
APGEEAHD_00318 9.6e-32 L transposition
APGEEAHD_00319 6.5e-54 L transposition
APGEEAHD_00320 7.7e-19 L transposase activity
APGEEAHD_00321 0.0 3.6.3.8 P cation transport ATPase
APGEEAHD_00322 0.0 pabB 2.6.1.85, 4.1.3.27, 4.1.3.38 EH component I
APGEEAHD_00324 0.0 metE 2.1.1.14 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
APGEEAHD_00325 7.3e-166 metF 1.5.1.20 E reductase
APGEEAHD_00326 7.6e-134 5.1.3.2 GM Psort location CytoplasmicMembrane, score
APGEEAHD_00327 1.4e-143
APGEEAHD_00328 0.0 S Uncharacterised protein conserved in bacteria (DUF2194)
APGEEAHD_00329 2.6e-274 pelF GT4 M Domain of unknown function (DUF3492)
APGEEAHD_00330 2.1e-186 pelG M Putative exopolysaccharide Exporter (EPS-E)
APGEEAHD_00331 1.5e-211 cotH M CotH kinase protein
APGEEAHD_00332 7.1e-52 G Domain of unknown function (DUF4832)
APGEEAHD_00333 4.9e-21 G Domain of unknown function (DUF4832)
APGEEAHD_00334 2.3e-195 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
APGEEAHD_00336 5.5e-231 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APGEEAHD_00337 1.2e-25 epuA S DNA-directed RNA polymerase subunit beta
APGEEAHD_00338 3.5e-123 endA F DNA RNA non-specific endonuclease
APGEEAHD_00339 4.2e-110 tcyB_2 P ABC transporter (permease)
APGEEAHD_00340 8e-115 gltJ P ABC transporter (Permease
APGEEAHD_00341 3.1e-150 peb1A ET ABC-type amino acid transport signal transduction systems, periplasmic component domain
APGEEAHD_00342 2.1e-140 glnQ 3.6.3.21 E abc transporter atp-binding protein
APGEEAHD_00343 9.9e-129 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
APGEEAHD_00344 1.5e-247 vicK 2.7.13.3 T Histidine kinase
APGEEAHD_00345 2.1e-154 vicX 3.1.26.11 S Metal-dependent hydrolases of the beta-lactamase superfamily I
APGEEAHD_00346 9e-231 murM 2.3.2.10, 2.3.2.16 V protein involved in methicillin resistance
APGEEAHD_00347 4.6e-146 yidA S hydrolases of the HAD superfamily
APGEEAHD_00348 6.3e-51 XK27_00115 2.3.1.128 K acetyltransferase
APGEEAHD_00349 2.6e-67 ywiB S Domain of unknown function (DUF1934)
APGEEAHD_00350 0.0 pacL 3.6.3.8 P cation transport ATPase
APGEEAHD_00351 4.4e-135 nfrA 1.5.1.38, 1.5.1.39 C nitroreductase
APGEEAHD_00352 1.3e-181 yjjH S Calcineurin-like phosphoesterase
APGEEAHD_00353 1.2e-202 queG 1.17.99.6 C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APGEEAHD_00354 1.6e-182 prfB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APGEEAHD_00355 2.5e-124 ftsE D cell division ATP-binding protein FtsE
APGEEAHD_00356 3.6e-163 ftsX D Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation
APGEEAHD_00357 3.5e-93 mutX 3.6.1.55 F NTP pyrophosphohydrolases including oxidative damage repair enzymes
APGEEAHD_00358 2.3e-175 yubA S permease
APGEEAHD_00359 4.9e-224 G COG0457 FOG TPR repeat
APGEEAHD_00360 1e-96 lepB 3.4.21.89 U Belongs to the peptidase S26 family
APGEEAHD_00361 6.7e-234 pepT 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
APGEEAHD_00362 2.9e-90 ebsA S Family of unknown function (DUF5322)
APGEEAHD_00363 3.9e-15 M LysM domain
APGEEAHD_00364 2.5e-121 cmk 1.17.7.4, 2.5.1.19, 2.7.1.26, 2.7.4.25, 2.7.7.2, 6.3.2.1 F Belongs to the cytidylate kinase family. Type 1 subfamily
APGEEAHD_00365 3.5e-86 infC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
APGEEAHD_00366 2.1e-28 rpmI J Belongs to the bacterial ribosomal protein bL35 family
APGEEAHD_00367 1.5e-56 rplT J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
APGEEAHD_00368 5.8e-42 L Transposase
APGEEAHD_00369 1.6e-24 L Transposase
APGEEAHD_00370 1.7e-47 XK27_03610 K Gnat family
APGEEAHD_00371 6.4e-27 dmpI 5.3.2.6 G Belongs to the 4-oxalocrotonate tautomerase family
APGEEAHD_00372 6.9e-275 pepV 3.5.1.18 E Dipeptidase
APGEEAHD_00373 1e-110 ung2 3.2.2.27 L Uracil-DNA glycosylase
APGEEAHD_00374 4e-21 V Glucan-binding protein C
APGEEAHD_00376 1.7e-122 rpiA 2.7.1.12, 2.7.1.15, 5.3.1.6 G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
APGEEAHD_00377 1.1e-236 deoB 5.4.2.7 G Phosphotransfer between the C1 and C5 carbon atoms of pentose
APGEEAHD_00378 8.1e-41 S Protein of unknown function (DUF1697)
APGEEAHD_00379 2e-149 punA 2.4.2.1 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
APGEEAHD_00380 8e-65 clcA_2 P chloride
APGEEAHD_00381 3.7e-67 yfeJ 6.3.5.2 F glutamine amidotransferase
APGEEAHD_00382 7e-38 yfeJ 6.3.5.2 F glutamine amidotransferase
APGEEAHD_00383 1.7e-128 deoD 2.4.2.1, 2.4.2.28 F purine nucleoside phosphorylase
APGEEAHD_00384 1.1e-246 cps4A K Cell envelope-like function transcriptional attenuator common domain protein
APGEEAHD_00385 1.1e-83 cpsB 3.1.3.48 GM Capsular polysaccharide biosynthesis protein
APGEEAHD_00386 1.6e-242 epsU S Polysaccharide biosynthesis protein
APGEEAHD_00387 7.4e-216 glf 5.4.99.9 M UDP-galactopyranose mutase
APGEEAHD_00388 1.5e-170 sacB GT2,GT4 M Stealth protein CR2, conserved region 2
APGEEAHD_00389 1.5e-194 wbbI M transferase activity, transferring glycosyl groups
APGEEAHD_00390 1.1e-23 L Transposase
APGEEAHD_00391 5.1e-170 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
APGEEAHD_00392 2e-186 gpsA 1.1.1.94 I Glycerol-3-phosphate dehydrogenase
APGEEAHD_00393 5.5e-64 XK27_08585 S Psort location CytoplasmicMembrane, score
APGEEAHD_00394 3.2e-62 fnt P Formate nitrite transporter
APGEEAHD_00395 2.3e-141 XK27_09615 C reductase
APGEEAHD_00396 9e-62 XK27_09615 C reductase
APGEEAHD_00397 4.3e-77 XK27_09620 S reductase
APGEEAHD_00398 4.7e-20 XK27_09620 S FMN reductase (NADPH) activity
APGEEAHD_00399 1.1e-80 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
APGEEAHD_00400 1.4e-226 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
APGEEAHD_00401 6.2e-12 WQ51_05710 S Mitochondrial biogenesis AIM24
APGEEAHD_00402 7.3e-59 WQ51_05710 S Mitochondrial biogenesis AIM24
APGEEAHD_00403 2e-88 cah 4.2.1.1 P Reversible hydration of carbon dioxide
APGEEAHD_00404 3.5e-50 S Protein of unknown function (DUF3397)
APGEEAHD_00405 3.7e-70 rplK J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
APGEEAHD_00406 4.8e-120 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
APGEEAHD_00407 4.2e-74 amiA E transmembrane transport
APGEEAHD_00408 6.7e-81 amiA E transmembrane transport
APGEEAHD_00409 2.1e-282 gltX 6.1.1.17, 6.1.1.24 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APGEEAHD_00410 2e-230 argG 6.3.4.5 E Belongs to the argininosuccinate synthase family. Type 1 subfamily
APGEEAHD_00411 1.2e-263 argH 4.3.2.1 E Argininosuccinate lyase
APGEEAHD_00412 1.3e-54 rnpA 3.1.26.5 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
APGEEAHD_00413 1.7e-140 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
APGEEAHD_00414 5.5e-184 jag S RNA-binding protein
APGEEAHD_00415 1e-13 rpmH J Ribosomal protein L34
APGEEAHD_00416 5e-84 L Transposase
APGEEAHD_00417 1.7e-226 tgt 2.4.2.29 F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
APGEEAHD_00418 2e-222 pgk 2.7.2.3, 5.3.1.1 F Belongs to the phosphoglycerate kinase family
APGEEAHD_00419 1.5e-12
APGEEAHD_00420 2.3e-87 S Fusaric acid resistance protein-like
APGEEAHD_00421 8.5e-63 glnR K Transcriptional regulator
APGEEAHD_00422 1.5e-263 glnA 6.3.1.2 E glutamine synthetase
APGEEAHD_00423 3.2e-41 pscB M CHAP domain protein
APGEEAHD_00424 0.0 rnjA S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
APGEEAHD_00425 2.5e-33 ykzG S Belongs to the UPF0356 family
APGEEAHD_00426 5.6e-121 yeaZ 2.3.1.234 O COG1214, inactive homolog of metal-dependent proteases
APGEEAHD_00427 2.4e-72 rimI 2.3.1.128 K This enzyme acetylates the N-terminal alanine of ribosomal protein S18
APGEEAHD_00428 1.9e-186 tsaD 2.3.1.234 O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
APGEEAHD_00429 1.8e-114 azlC E AzlC protein
APGEEAHD_00430 2e-47 azlD E branched-chain amino acid
APGEEAHD_00431 0.0 recD2 3.1.11.5 L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
APGEEAHD_00432 1.3e-113 lepB 3.4.21.89 U Belongs to the peptidase S26 family
APGEEAHD_00433 4.7e-160 rnhC 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APGEEAHD_00434 2.3e-13 zapA D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
APGEEAHD_00435 1e-93 cvpA S toxin biosynthetic process
APGEEAHD_00436 0.0 mutS2 L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
APGEEAHD_00437 0.0 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APGEEAHD_00442 2.5e-230 mutY L A G-specific adenine glycosylase
APGEEAHD_00443 3.6e-41 XK27_05745
APGEEAHD_00444 3.9e-47 rpsF J Binds together with S18 to 16S ribosomal RNA
APGEEAHD_00445 2.7e-91 ssb L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
APGEEAHD_00446 9.7e-36 rpsR J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
APGEEAHD_00448 3.1e-124 XK27_01040 S Pfam PF06570
APGEEAHD_00449 2e-169 corA P COG0598 Mg2 and Co2 transporters
APGEEAHD_00450 0.0 uvrA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APGEEAHD_00453 1e-58 V 'abc transporter, ATP-binding protein
APGEEAHD_00454 1.2e-42 V 'abc transporter, ATP-binding protein
APGEEAHD_00456 5e-193 pepP 3.4.11.9, 3.4.13.9 E Belongs to the peptidase M24B family
APGEEAHD_00457 3.7e-84 comEB 3.5.4.12 F ComE operon protein 2
APGEEAHD_00458 1.2e-97 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APGEEAHD_00459 3.4e-62 yqhY S protein conserved in bacteria
APGEEAHD_00460 2.1e-73 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APGEEAHD_00461 2.2e-179 scrR K Transcriptional
APGEEAHD_00462 5.4e-291 scrB 3.2.1.26 GH32 G invertase
APGEEAHD_00463 0.0 scrA 2.7.1.208, 2.7.1.211 G pts system
APGEEAHD_00464 4.1e-172 scrK 2.7.1.2, 2.7.1.4 GK Fructokinase
APGEEAHD_00465 3e-189 manA 5.3.1.8 G mannose-6-phosphate isomerase
APGEEAHD_00467 0.0 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
APGEEAHD_00468 2.9e-198 aroF 2.5.1.54 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APGEEAHD_00469 1.1e-197 aroF 2.5.1.54 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APGEEAHD_00470 4.5e-61 acpS 2.7.6.3, 2.7.8.7, 5.1.1.1 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
APGEEAHD_00471 1.9e-182 alr 5.1.1.1, 5.1.1.5 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APGEEAHD_00472 0.0 recG 3.6.4.12 L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APGEEAHD_00474 3.8e-173 ansA 3.5.1.1 EJ COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D
APGEEAHD_00475 3.1e-259 XK27_03190 5.2.1.8 S hydrolases of the HAD superfamily
APGEEAHD_00476 2.9e-18 yebC M Membrane
APGEEAHD_00477 5.9e-54 yebC M Membrane
APGEEAHD_00478 1.7e-16 KT response to antibiotic
APGEEAHD_00479 3.6e-66 KT response to antibiotic
APGEEAHD_00480 5.2e-75 XK27_02470 K LytTr DNA-binding domain
APGEEAHD_00481 2.6e-121 liaI S membrane
APGEEAHD_00482 0.0 rexB 3.1.21.3, 3.6.4.12 L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
APGEEAHD_00483 0.0 addA 3.6.4.12 L ATP-dependent helicase nuclease subunit A
APGEEAHD_00484 5.2e-125 S Protein of unknown function (DUF554)
APGEEAHD_00485 8.1e-134 ecsA_2 V abc transporter atp-binding protein
APGEEAHD_00486 2.4e-284 XK27_00765
APGEEAHD_00487 5.7e-141 proB 2.7.2.11 E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
APGEEAHD_00488 5.8e-225 proA 1.2.1.41 E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
APGEEAHD_00489 4.5e-18 D nuclear chromosome segregation
APGEEAHD_00490 8.7e-33 yhaI J Protein of unknown function (DUF805)
APGEEAHD_00492 2.6e-30
APGEEAHD_00493 7.4e-27
APGEEAHD_00494 3.6e-65
APGEEAHD_00495 3e-157 rsmH 2.1.1.199 J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
APGEEAHD_00496 4.3e-47 ftsL D cell division protein FtsL
APGEEAHD_00497 0.0 ftsI 3.4.16.4 M penicillin-binding protein
APGEEAHD_00498 6.3e-185 mraY 2.7.8.13 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APGEEAHD_00499 3.2e-221 cshB 3.6.4.13 JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
APGEEAHD_00501 5.1e-270 yunD 3.1.3.5 F Belongs to the 5'-nucleotidase family
APGEEAHD_00502 1.4e-69 yutD J protein conserved in bacteria
APGEEAHD_00503 1.1e-222 rlmN 2.1.1.192 J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
APGEEAHD_00504 8.5e-93 XK27_09885 V Glycopeptide antibiotics resistance protein
APGEEAHD_00506 3.8e-301 mdlA V abc transporter atp-binding protein
APGEEAHD_00507 0.0 mdlB V abc transporter atp-binding protein
APGEEAHD_00508 0.0 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
APGEEAHD_00509 7.3e-237 mesE M Transport protein ComB
APGEEAHD_00511 3e-235 blpH 2.7.13.3 T protein histidine kinase activity
APGEEAHD_00512 8.9e-133 agrA KT phosphorelay signal transduction system
APGEEAHD_00515 4.3e-25 S Bacteriocin class II with double-glycine leader peptide
APGEEAHD_00521 4.5e-17
APGEEAHD_00522 4.2e-261 asnS 6.1.1.22 J Catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
APGEEAHD_00523 1.6e-216 aspB 2.6.1.1, 2.6.1.14 E Aminotransferase
APGEEAHD_00524 3.1e-81 ypmB S Protein conserved in bacteria
APGEEAHD_00525 0.0 dinG 2.7.7.7, 3.6.4.12 L helicase involved in DNA repair and perhaps also replication
APGEEAHD_00526 8.9e-121 ycbL 3.1.2.6 S COG0491 Zn-dependent hydrolases, including glyoxylases
APGEEAHD_00527 4.8e-171 yufQ S Belongs to the binding-protein-dependent transport system permease family
APGEEAHD_00528 4.7e-191 yufP S Belongs to the binding-protein-dependent transport system permease family
APGEEAHD_00529 3.7e-282 xylG 3.6.3.17 S ABC transporter, ATP-binding protein
APGEEAHD_00530 9.5e-192 tcsA S ABC-type transport system, periplasmic component surface lipoprotein
APGEEAHD_00531 1.3e-69 cdd 2.4.2.2, 3.5.4.5 F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
APGEEAHD_00532 4e-63 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
APGEEAHD_00533 2.9e-30 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
APGEEAHD_00534 7.2e-95 pdp 2.4.2.2, 2.4.2.4 F Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate
APGEEAHD_00535 3e-23 pdp 2.4.2.2, 2.4.2.4 F phosphorylase activity
APGEEAHD_00536 2.3e-26 pdp 2.4.2.2, 2.4.2.4 F Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate
APGEEAHD_00537 3.7e-105 rsmC 2.1.1.172 J Methyltransferase small domain protein
APGEEAHD_00538 1.2e-171 coaA 2.7.1.33 F Pantothenic acid kinase
APGEEAHD_00539 2.1e-30 rpsT J rRNA binding
APGEEAHD_00540 9.5e-152 L Integrase core domain protein
APGEEAHD_00541 1.8e-189
APGEEAHD_00542 2.3e-309 FbpA K RNA-binding protein homologous to eukaryotic snRNP
APGEEAHD_00544 3.9e-15 dinF V Mate efflux family protein
APGEEAHD_00545 3.3e-19 yclQ P ABC-type enterochelin transport system, periplasmic component
APGEEAHD_00546 9.4e-15 yclQ P ABC-type enterochelin transport system, periplasmic component
APGEEAHD_00547 4.1e-118 gph 3.1.3.18 S HAD hydrolase, family IA, variant 1
APGEEAHD_00548 1.2e-143 2.4.2.3 F Phosphorylase superfamily
APGEEAHD_00551 3.8e-78 S Alpha/beta hydrolase of unknown function (DUF915)
APGEEAHD_00552 7.9e-17 S Alpha/beta hydrolase of unknown function (DUF915)
APGEEAHD_00553 6e-08 S Hydrolases of the alpha beta superfamily
APGEEAHD_00554 6.2e-196 adhB 1.1.1.1, 1.1.1.14 E Dehydrogenase
APGEEAHD_00555 2.7e-210 hemH 4.99.1.1, 4.99.1.9 H Catalyzes the ferrous insertion into protoporphyrin IX
APGEEAHD_00556 1.8e-159 czcD P cation diffusion facilitator family transporter
APGEEAHD_00557 9e-98 K Transcriptional regulator, TetR family
APGEEAHD_00558 1.6e-10
APGEEAHD_00559 4.5e-113 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
APGEEAHD_00560 2.7e-116 V ABC transporter (Permease
APGEEAHD_00561 5.3e-43 L Transposase
APGEEAHD_00562 5.7e-95
APGEEAHD_00563 6e-55 J Acetyltransferase (GNAT) domain
APGEEAHD_00564 1.2e-250 rumA 2.1.1.190 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APGEEAHD_00565 4.5e-97 mip S hydroperoxide reductase activity
APGEEAHD_00566 2.4e-203 I acyl-CoA dehydrogenase
APGEEAHD_00567 2.2e-149 ydiA P C4-dicarboxylate transporter malic acid transport protein
APGEEAHD_00568 6.4e-252 msrR K Transcriptional regulator
APGEEAHD_00569 6.7e-153 pheA 4.2.1.51 E Prephenate dehydratase
APGEEAHD_00570 1.7e-87 aroK 1.1.1.25, 2.7.1.71, 4.2.1.10, 4.2.3.4 F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APGEEAHD_00571 2.6e-236 aroA 1.3.1.12, 1.3.1.43, 2.5.1.19 E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
APGEEAHD_00572 3e-173 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
APGEEAHD_00573 3.2e-53 yheA S Belongs to the UPF0342 family
APGEEAHD_00574 8.3e-207 tyrA 1.3.1.12, 1.3.1.43 E prephenate dehydrogenase
APGEEAHD_00575 4.5e-219 aroC 4.2.3.5 E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
APGEEAHD_00576 3.5e-202 aroB 2.7.1.71, 4.2.3.4 E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APGEEAHD_00577 1.8e-161 aroE 1.1.1.25 E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APGEEAHD_00578 8.6e-122 aroD 1.1.1.25, 4.2.1.10 E Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
APGEEAHD_00579 2e-219 ywbD 2.1.1.191 J Methyltransferase
APGEEAHD_00580 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
APGEEAHD_00581 2e-25 WQ51_00785
APGEEAHD_00582 9.6e-247 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
APGEEAHD_00583 1e-78 yueI S Protein of unknown function (DUF1694)
APGEEAHD_00584 1.6e-205 glxK 2.7.1.165 G Belongs to the glycerate kinase type-1 family
APGEEAHD_00585 6.6e-101 yyaQ V Protein conserved in bacteria
APGEEAHD_00586 2.8e-28 yyaQ S YjbR
APGEEAHD_00587 4.4e-183 ccpA K Catabolite control protein A
APGEEAHD_00588 4.2e-211 pepQ 3.4.13.9 E Belongs to the peptidase M24B family
APGEEAHD_00589 1.7e-63 yugI 5.3.1.9 J RNA binding protein, contains ribosomal protein S1 domain
APGEEAHD_00590 9.6e-277 ppiB 5.2.1.8 G PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APGEEAHD_00591 1.1e-80 smpB O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
APGEEAHD_00592 0.0 rnr J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
APGEEAHD_00593 2.6e-33 secG U Preprotein translocase subunit SecG
APGEEAHD_00594 1.6e-219 mdtG EGP Major facilitator Superfamily
APGEEAHD_00595 1.3e-105 coaE 2.7.1.24, 3.2.2.23, 4.2.99.18 GH23 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
APGEEAHD_00596 5.5e-155 fpg 3.2.2.23, 4.2.99.18 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
APGEEAHD_00597 1.3e-165 era M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
APGEEAHD_00598 1.7e-64 dgkA 2.7.1.107, 2.7.1.66 M Diacylglycerol kinase
APGEEAHD_00599 5.9e-88 ybeY 2.6.99.2, 3.5.4.5 S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
APGEEAHD_00600 6.8e-53 licT K transcriptional antiterminator
APGEEAHD_00601 5.8e-64 licT K transcriptional antiterminator
APGEEAHD_00602 4.9e-105 recR L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
APGEEAHD_00603 0.0 pbp2b 3.4.16.4 M penicillin-binding protein
APGEEAHD_00604 7.8e-149 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
APGEEAHD_00605 3.9e-156 folD 1.5.1.5, 3.5.4.9 F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
APGEEAHD_00606 7.5e-23 I Alpha/beta hydrolase family
APGEEAHD_00607 2.5e-33 yugF I carboxylic ester hydrolase activity
APGEEAHD_00608 2.2e-45 K sequence-specific DNA binding
APGEEAHD_00609 2.4e-104 1.1.1.133, 5.1.3.13 M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
APGEEAHD_00610 1.5e-07
APGEEAHD_00611 0.0 feoB P transporter of a GTP-driven Fe(2 ) uptake system
APGEEAHD_00612 1.1e-78 feoA P FeoA domain protein
APGEEAHD_00613 2.2e-131 glnQ 3.6.3.21 E abc transporter atp-binding protein
APGEEAHD_00614 2.2e-117 WQ51_01820 P Binding-protein-dependent transport system inner membrane component
APGEEAHD_00616 1.3e-34 ykuJ S protein conserved in bacteria
APGEEAHD_00617 1.2e-180 argF 2.1.3.3 E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APGEEAHD_00618 0.0 clpE O Belongs to the ClpA ClpB family
APGEEAHD_00619 1.8e-86 mutT 3.5.4.33, 3.6.1.13, 3.6.1.55 L Belongs to the Nudix hydrolase family
APGEEAHD_00620 3.7e-48 XK27_09445 S Domain of unknown function (DUF1827)
APGEEAHD_00621 9.7e-66 S oxidoreductase
APGEEAHD_00622 9.3e-59 S oxidoreductase
APGEEAHD_00623 1.3e-232 murN 2.3.2.10, 2.3.2.16 V FemAB family
APGEEAHD_00624 6.1e-70 M Pfam SNARE associated Golgi protein
APGEEAHD_00625 2.6e-101 S Domain of Unknown Function with PDB structure (DUF3862)
APGEEAHD_00628 8.4e-205 rpsA 1.17.7.4 J ribosomal protein S1
APGEEAHD_00631 4.8e-16 S Protein of unknown function (DUF2969)
APGEEAHD_00632 2.4e-200 ilvE 2.6.1.42 E Aminotransferase
APGEEAHD_00633 0.0 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
APGEEAHD_00634 0.0 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
APGEEAHD_00635 7.1e-102 plsY 2.3.1.15, 3.5.1.104 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
APGEEAHD_00636 4.9e-15 L Helix-hairpin-helix DNA-binding motif class 1
APGEEAHD_00637 1.4e-29 S Domain of unknown function (DUF1912)
APGEEAHD_00638 1.2e-177 mmuM 1.5.1.20, 2.1.1.10 H Homocysteine
APGEEAHD_00639 1.5e-250 mmuP E amino acid
APGEEAHD_00640 3e-110 engB D Necessary for normal cell division and for the maintenance of normal septation
APGEEAHD_00641 2e-225 clpX O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
APGEEAHD_00642 9.7e-22
APGEEAHD_00643 3.4e-91 folA 1.5.1.3, 1.5.1.47, 2.1.1.45, 3.5.4.12 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
APGEEAHD_00644 2.2e-167 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
APGEEAHD_00645 1.7e-218 mvaS 2.3.3.10 I synthase
APGEEAHD_00646 2.7e-233 mvaA 1.1.1.34, 1.1.1.88, 2.3.1.9 C Belongs to the HMG-CoA reductase family
APGEEAHD_00647 1e-25 K hmm pf08876
APGEEAHD_00648 1.5e-118 yqfA K protein, Hemolysin III
APGEEAHD_00649 1.2e-22 S Protein of unknown function (DUF3114)
APGEEAHD_00650 8e-165 S Protein of unknown function (DUF3114)
APGEEAHD_00651 3.6e-70 S hydrolases or acyltransferases (alpha beta hydrolase superfamily)
APGEEAHD_00652 9.2e-48 S hydrolases or acyltransferases (alpha beta hydrolase superfamily)
APGEEAHD_00653 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
APGEEAHD_00654 4.9e-21 XK27_13030
APGEEAHD_00655 1.8e-248 mgs 2.4.1.337 GT4 M Glycosyltransferase, group 1 family protein
APGEEAHD_00656 1.1e-192 dgs 2.4.1.208 GT4 M Glycosyltransferase, group 1 family protein
APGEEAHD_00657 1.1e-11 U protein secretion
APGEEAHD_00658 1.6e-50 U protein secretion
APGEEAHD_00659 3.5e-07 U protein secretion
APGEEAHD_00661 5.9e-118 mtnN 3.2.2.9 E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
APGEEAHD_00662 2.5e-21
APGEEAHD_00663 1e-96 nudF 3.6.1.13 L AdP-ribose pyrophosphatase
APGEEAHD_00664 5.1e-254 glmU 2.3.1.157, 2.7.7.23 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
APGEEAHD_00665 8.9e-192 fni 1.1.1.88, 5.3.3.2 C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
APGEEAHD_00666 4.6e-180 mvaK2 2.7.1.36, 2.7.1.43, 2.7.4.2 I GHMP kinases N terminal domain
APGEEAHD_00667 1.3e-173 mvaD 4.1.1.33 I diphosphomevalonate decarboxylase
APGEEAHD_00668 3.7e-141 mvk 1.1.1.88, 2.3.3.10, 2.7.1.36 I mevalonate kinase
APGEEAHD_00669 4.6e-105 GBS0088 J protein conserved in bacteria
APGEEAHD_00670 8e-249 merA 1.16.1.1 C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APGEEAHD_00671 1.7e-46 ald 1.4.1.1 C Belongs to the AlaDH PNT family
APGEEAHD_00672 3.4e-17 ald 1.4.1.1 E alanine dehydrogenase activity
APGEEAHD_00673 2.4e-217 hipO 3.5.1.47 E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
APGEEAHD_00674 7.4e-132 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
APGEEAHD_00675 1.1e-81 S VIT family
APGEEAHD_00676 2.8e-22 S VIT family
APGEEAHD_00677 1.4e-144 deoD_1 2.4.2.3 F Phosphorylase superfamily
APGEEAHD_00678 1.9e-22
APGEEAHD_00679 8e-28 XK27_00085 K Transcriptional
APGEEAHD_00680 6.9e-197 yceA S Belongs to the UPF0176 family
APGEEAHD_00681 5.4e-122 sagI S ABC-2 type transporter
APGEEAHD_00682 2.8e-168 V ABC transporter
APGEEAHD_00683 1.3e-218 2.7.7.73, 2.7.7.80 H Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
APGEEAHD_00684 2.5e-132 rr02 KT response regulator
APGEEAHD_00685 6.3e-214 2.7.13.3 T signal transduction protein with a C-terminal ATPase domain
APGEEAHD_00686 5.8e-121 nagB 3.1.1.31, 3.5.99.6 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
APGEEAHD_00687 4.6e-199 queA 2.4.99.17 J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
APGEEAHD_00688 0.0 lmrA V abc transporter atp-binding protein
APGEEAHD_00689 0.0 mdlB V abc transporter atp-binding protein
APGEEAHD_00691 0.0 pgm 5.4.2.2, 5.4.2.8 G Phosphoglucomutase
APGEEAHD_00692 4.1e-93 panT S ECF transporter, substrate-specific component
APGEEAHD_00693 4.8e-94 coaBC 4.1.1.36, 6.3.2.5 H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APGEEAHD_00694 1.2e-120 coaB 4.1.1.36, 6.3.2.5 H Phosphopantothenate-cysteine ligase
APGEEAHD_00695 0.0 fhs 6.3.4.3 F Belongs to the formate--tetrahydrofolate ligase family
APGEEAHD_00696 6.4e-66 T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
APGEEAHD_00697 2.8e-40 T PhoQ Sensor
APGEEAHD_00698 1.7e-43 T PhoQ Sensor
APGEEAHD_00699 3.6e-88 T PhoQ Sensor
APGEEAHD_00700 1.1e-151 V MatE
APGEEAHD_00702 3.9e-110 C Fe-S oxidoreductases
APGEEAHD_00703 1.2e-176 EGP Major Facilitator Superfamily
APGEEAHD_00704 5.5e-258 I radical SAM domain protein
APGEEAHD_00706 6.5e-159 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
APGEEAHD_00707 1.4e-150 L Integrase core domain protein
APGEEAHD_00708 1.8e-87 L transposase activity
APGEEAHD_00710 2.8e-85
APGEEAHD_00711 0.0 sbcC L ATPase involved in DNA repair
APGEEAHD_00712 6.9e-231 sbcD L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
APGEEAHD_00713 0.0 lacL 3.2.1.23 G -beta-galactosidase
APGEEAHD_00714 0.0 lacS G transporter
APGEEAHD_00715 6.4e-201 galM 5.1.3.3 G Catalyzes the interconversion of alpha and beta anomers of maltose
APGEEAHD_00716 6.6e-195 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
APGEEAHD_00717 8e-290 galT 2.7.7.12 G UDPglucose--hexose-1-phosphate uridylyltransferase
APGEEAHD_00718 4.8e-221 galK 2.7.1.6 G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
APGEEAHD_00719 2.3e-184 galR K Transcriptional regulator
APGEEAHD_00720 1.2e-25 L transposition
APGEEAHD_00721 3.3e-74 M translation initiation factor activity
APGEEAHD_00722 7.5e-109 M translation initiation factor activity
APGEEAHD_00723 1.4e-67 rtxA M M26 IgA1-specific Metallo-endopeptidase C-terminal region
APGEEAHD_00724 1.1e-23 V abc transporter atp-binding protein
APGEEAHD_00725 3e-26 V abc transporter atp-binding protein
APGEEAHD_00726 1.7e-20 V abc transporter atp-binding protein
APGEEAHD_00727 4.3e-40 V abc transporter atp-binding protein
APGEEAHD_00728 0.0 gshF 6.3.2.2, 6.3.2.29, 6.3.2.30, 6.3.2.4 H Belongs to the glutamate--cysteine ligase type 1 family
APGEEAHD_00729 1.4e-61 L Transposase
APGEEAHD_00730 7e-150 pulA 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
APGEEAHD_00731 1.8e-33 pulA 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
APGEEAHD_00732 1.7e-120 pulA 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
APGEEAHD_00733 0.0 ftsK D Belongs to the FtsK SpoIIIE SftA family
APGEEAHD_00734 5.9e-188 trxB1 1.18.1.2, 1.19.1.1 C Ferredoxin--NADP reductase
APGEEAHD_00735 1.4e-135 trmD 2.1.1.228, 4.6.1.12 J Belongs to the RNA methyltransferase TrmD family
APGEEAHD_00736 5.8e-94 rimM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
APGEEAHD_00739 2.2e-114 vraR K Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
APGEEAHD_00740 5.8e-175 vraS 2.7.13.3 T Histidine kinase
APGEEAHD_00741 3.7e-120 yvqF KT membrane
APGEEAHD_00742 4.5e-306 prkC 2.7.11.1 KLT serine threonine protein kinase
APGEEAHD_00743 2e-132 stp 3.1.3.16 T phosphatase
APGEEAHD_00744 4.4e-247 sun 2.1.1.176 J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APGEEAHD_00745 2.5e-172 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
APGEEAHD_00746 0.0 priA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
APGEEAHD_00747 2.7e-46 rpoZ 2.7.7.6 K DNA-directed 5'-3' RNA polymerase activity
APGEEAHD_00748 9.8e-112 gmk 2.7.4.8 F Essential for recycling GMP and indirectly, cGMP
APGEEAHD_00749 2.8e-212 ftsY U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
APGEEAHD_00750 6.9e-150 XK27_02985 S overlaps another CDS with the same product name
APGEEAHD_00751 2.1e-148 supH S overlaps another CDS with the same product name
APGEEAHD_00752 8.6e-63 yvoA_1 K Transcriptional
APGEEAHD_00753 2.8e-120 skfE V abc transporter atp-binding protein
APGEEAHD_00754 3.3e-133 V ATPase activity
APGEEAHD_00755 4.3e-172 oppF P Belongs to the ABC transporter superfamily
APGEEAHD_00756 2.2e-204 oppD P Belongs to the ABC transporter superfamily
APGEEAHD_00757 4.9e-168 amiD P ABC transporter (Permease
APGEEAHD_00758 4.2e-278 amiC P ABC transporter (Permease
APGEEAHD_00759 1.7e-259 pepC 3.4.22.40 E aminopeptidase
APGEEAHD_00760 3.2e-77 yhaI L Membrane
APGEEAHD_00761 4.8e-151 nadE 6.3.1.5 H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
APGEEAHD_00762 9.6e-280 pncB 6.3.4.21 H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
APGEEAHD_00763 5.6e-138 S COG1073 Hydrolases of the alpha beta superfamily
APGEEAHD_00764 7.4e-89 S thiolester hydrolase activity
APGEEAHD_00765 3.8e-40 K transcriptional
APGEEAHD_00766 0.0 leuS 6.1.1.4 J Belongs to the class-I aminoacyl-tRNA synthetase family
APGEEAHD_00767 4.5e-135 glcR K transcriptional regulator (DeoR family)
APGEEAHD_00768 1.1e-34 cof Q phosphatase activity
APGEEAHD_00769 6e-55 cof Q phosphatase activity
APGEEAHD_00770 4.6e-85 3.1.3.27, 3.1.3.4, 3.1.3.81, 3.6.1.27 I phosphatidate phosphatase activity
APGEEAHD_00771 8.4e-96 nusG K Participates in transcription elongation, termination and antitermination
APGEEAHD_00772 5.7e-25 secE U Belongs to the SecE SEC61-gamma family
APGEEAHD_00773 3.3e-21 rpmG J Belongs to the bacterial ribosomal protein bL33 family
APGEEAHD_00774 0.0 pbp2A 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
APGEEAHD_00775 1.2e-165 rluA 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
APGEEAHD_00776 1.7e-54 S TM2 domain
APGEEAHD_00777 5.3e-16
APGEEAHD_00781 1.4e-121 ktrA P COG0569 K transport systems, NAD-binding component
APGEEAHD_00782 2.1e-244 P COG0168 Trk-type K transport systems, membrane components
APGEEAHD_00783 1.1e-130 rsmG 2.1.1.170 J Ribosomal RNA small subunit methyltransferase G
APGEEAHD_00784 2.4e-90 yceD K metal-binding, possibly nucleic acid-binding protein
APGEEAHD_00785 3e-122 T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
APGEEAHD_00786 2.8e-282 T PhoQ Sensor
APGEEAHD_00787 4.7e-82 nrdR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APGEEAHD_00788 6.5e-218 dnaB L Replication initiation and membrane attachment
APGEEAHD_00789 4.4e-166 dnaI L Primosomal protein DnaI
APGEEAHD_00790 2.6e-247 der 1.1.1.399, 1.1.1.95 S GTPase that plays an essential role in the late steps of ribosome biogenesis
APGEEAHD_00792 1.6e-34
APGEEAHD_00793 3.6e-65 yrdC 3.5.1.19 Q isochorismatase
APGEEAHD_00794 3e-27 L Integrase core domain protein
APGEEAHD_00795 1.3e-36 L transposition
APGEEAHD_00796 1.3e-276 pyk 2.7.1.40, 2.7.7.4 G Belongs to the pyruvate kinase family
APGEEAHD_00797 1.2e-188 pfkA 2.7.1.11 F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
APGEEAHD_00798 0.0 dnaE 2.7.7.7 L DNA polymerase
APGEEAHD_00799 1.4e-152 sua5 2.7.7.87 J Belongs to the SUA5 family
APGEEAHD_00800 3.1e-112 leuD 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
APGEEAHD_00801 6.8e-275 leuC 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
APGEEAHD_00802 2.5e-43 ysdA L Membrane
APGEEAHD_00803 6.6e-190 leuB 1.1.1.85 CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
APGEEAHD_00804 3.4e-291 leuA 2.3.3.13 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APGEEAHD_00805 4.6e-131 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
APGEEAHD_00806 3.6e-179 pyrD 1.3.1.14, 1.3.98.1 F Catalyzes the conversion of dihydroorotate to orotate
APGEEAHD_00808 2.8e-39 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
APGEEAHD_00809 1.7e-83 ypmS S Protein conserved in bacteria
APGEEAHD_00810 6e-144 ypmR E lipolytic protein G-D-S-L family
APGEEAHD_00811 1e-148 DegV S DegV family
APGEEAHD_00812 5.8e-305 recN L May be involved in recombinational repair of damaged DNA
APGEEAHD_00813 1.8e-72 argR K Regulates arginine biosynthesis genes
APGEEAHD_00814 5e-159 rrmJ 2.1.1.226, 2.1.1.227 J Ribosomal RNA large subunit methyltransferase J
APGEEAHD_00815 3e-159 ispA 2.5.1.1, 2.5.1.10, 2.5.1.29, 2.5.1.90 H Belongs to the FPP GGPP synthase family
APGEEAHD_00816 3.5e-29 xseB 3.1.11.6 L exodeoxyribonuclease VII activity
APGEEAHD_00817 1.2e-247 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
APGEEAHD_00820 3.4e-120 nth 4.2.99.18 L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APGEEAHD_00821 3.8e-125 dnaD
APGEEAHD_00822 9.3e-183 metA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APGEEAHD_00823 2e-94 apt 2.4.2.22, 2.4.2.7 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APGEEAHD_00824 0.0 recJ L Single-strand DNA-specific exonuclease, C terminal domain
APGEEAHD_00825 6.7e-139 XK27_05435 1.1.1.100 S Belongs to the short-chain dehydrogenases reductases (SDR) family
APGEEAHD_00826 9.2e-175 rnz 3.1.26.11 S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
APGEEAHD_00827 4.2e-118 galT 2.7.7.12 G UDPglucose--hexose-1-phosphate uridylyltransferase
APGEEAHD_00828 7.1e-223 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APGEEAHD_00829 1.6e-239 rodA D Belongs to the SEDS family
APGEEAHD_00830 1.8e-50 hisE 3.5.4.19, 3.6.1.31, 5.3.1.16 E Phosphoribosyl-ATP
APGEEAHD_00831 5.5e-61 hisI 3.5.4.19, 3.5.4.25, 3.6.1.31, 5.3.1.16 E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
APGEEAHD_00832 9.6e-138 hisF 3.5.4.19, 3.6.1.31 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
APGEEAHD_00833 1.7e-131 hisA 5.3.1.16 E 1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
APGEEAHD_00834 3.2e-112 hisH E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
APGEEAHD_00835 1.5e-106 hisB 1.1.1.23, 2.6.1.9, 3.1.3.15, 4.2.1.19 E imidazoleglycerol-phosphate dehydratase
APGEEAHD_00836 1.2e-233 hisD 1.1.1.23, 1.1.1.308 E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APGEEAHD_00837 1.4e-116 hisG 2.4.2.17 E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
APGEEAHD_00838 1.5e-183 hisZ 2.4.2.17, 6.1.1.21 E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
APGEEAHD_00839 1.5e-197 hisC 2.6.1.9 E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APGEEAHD_00841 2.7e-85 L Integrase core domain protein
APGEEAHD_00842 2.2e-41 L transposition
APGEEAHD_00843 3e-133 budA 4.1.1.5 H Belongs to the alpha-acetolactate decarboxylase family
APGEEAHD_00844 0.0 alsS 2.2.1.6 EH Belongs to the TPP enzyme family
APGEEAHD_00845 6.6e-61 EGP Major facilitator Superfamily
APGEEAHD_00846 4.4e-135 speB 3.5.3.11 E hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
APGEEAHD_00847 1.1e-212 pqqE C radical SAM domain protein
APGEEAHD_00850 4.4e-155 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
APGEEAHD_00851 0.0 lepA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
APGEEAHD_00852 3.9e-19 IQ Acetoin reductase
APGEEAHD_00853 5.8e-50 IQ Acetoin reductase
APGEEAHD_00854 1e-47 pspE P Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APGEEAHD_00855 1.7e-75 ndk 2.7.4.6 F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
APGEEAHD_00856 7.5e-21 XK27_05470 E Methionine synthase
APGEEAHD_00857 3.2e-152 XK27_05470 E Methionine synthase
APGEEAHD_00858 6.6e-259 trmFO 2.1.1.74 J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
APGEEAHD_00859 4.3e-253 T PhoQ Sensor
APGEEAHD_00860 6.4e-122 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
APGEEAHD_00861 5.1e-153 S TraX protein
APGEEAHD_00862 0.0 topA 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
APGEEAHD_00863 8.3e-159 dprA LU DNA protecting protein DprA
APGEEAHD_00864 4.1e-167 GK ROK family
APGEEAHD_00865 1.5e-135 rnhB 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APGEEAHD_00866 1.4e-158 ylqF S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
APGEEAHD_00867 6.9e-127 K DNA-binding helix-turn-helix protein
APGEEAHD_00868 8.6e-90 niaR S small molecule binding protein (contains 3H domain)
APGEEAHD_00869 3.1e-87 niaX
APGEEAHD_00870 6.1e-272 ffh 3.6.5.4 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APGEEAHD_00871 1.1e-53 ylxM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
APGEEAHD_00872 4.5e-126 gntR1 K transcriptional
APGEEAHD_00873 1.3e-303 guaA 2.3.1.128, 6.3.5.2 F Catalyzes the synthesis of GMP from XMP
APGEEAHD_00874 2.8e-49 sthIM 2.1.1.72 L Adenine specific DNA methylase Mod
APGEEAHD_00875 1.3e-106 adhP 1.1.1.1 C alcohol dehydrogenase
APGEEAHD_00876 3.4e-33 adhP 1.1.1.1 C alcohol dehydrogenase
APGEEAHD_00877 2.5e-139 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APGEEAHD_00878 3.5e-40 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APGEEAHD_00879 1.1e-158 aatB ET ABC transporter substrate-binding protein
APGEEAHD_00880 1.8e-113 glnQ 3.6.3.21 E abc transporter atp-binding protein
APGEEAHD_00881 2e-104 artQ P ABC transporter (Permease
APGEEAHD_00882 1.2e-57 phnA P Alkylphosphonate utilization operon protein PhnA
APGEEAHD_00883 0.0 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
APGEEAHD_00884 2.6e-166 cpsY K Transcriptional regulator
APGEEAHD_00885 1.7e-08
APGEEAHD_00887 1.2e-172 yeiH S Membrane
APGEEAHD_00888 5.5e-119 mur1 NU muramidase
APGEEAHD_00889 1.9e-83 L transposition
APGEEAHD_00890 2.2e-41 L transposition
APGEEAHD_00891 1.8e-44 L Integrase core domain protein
APGEEAHD_00892 1.1e-28 L Integrase core domain protein
APGEEAHD_00893 2.7e-188 gap 1.2.1.12 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
APGEEAHD_00894 0.0 fusA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APGEEAHD_00895 6.7e-81 rpsG J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
APGEEAHD_00896 2.3e-69 rpsL J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
APGEEAHD_00897 1.9e-33
APGEEAHD_00898 1.5e-233 cfa 2.1.1.317, 2.1.1.79 M cyclopropane-fatty-acyl-phospholipid synthase
APGEEAHD_00899 1.8e-56 amd 3.5.1.47 E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
APGEEAHD_00900 9.9e-19 S Domain of unknown function (DUF4649)
APGEEAHD_00901 1.6e-247 mnmE S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
APGEEAHD_00902 1.8e-240 agcS E (Alanine) symporter
APGEEAHD_00903 0.0 pcrA 3.6.4.12 L ATP-dependent DNA helicase
APGEEAHD_00904 3.5e-241 metY 2.5.1.49 E o-acetylhomoserine
APGEEAHD_00905 1.8e-59 Q phosphatase activity
APGEEAHD_00906 4.6e-61 S haloacid dehalogenase-like hydrolase
APGEEAHD_00907 3.5e-88 tpx 1.11.1.15 O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
APGEEAHD_00908 9e-110 hsdS2 2.1.1.72 V Type I restriction modification DNA specificity domain
APGEEAHD_00909 9.4e-46 XK27_04775 S hemerythrin HHE cation binding domain
APGEEAHD_00910 1.7e-58 XK27_04775 S hemerythrin HHE cation binding domain
APGEEAHD_00911 8.4e-151 truB 5.4.99.25 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
APGEEAHD_00912 2.6e-174 ribF 2.7.1.26, 2.7.7.2 H Belongs to the ribF family
APGEEAHD_00913 1.4e-71 spxA 1.20.4.1 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
APGEEAHD_00914 6.7e-44 yktA S Belongs to the UPF0223 family
APGEEAHD_00915 4.2e-141 suhB 3.1.3.25 G Belongs to the inositol monophosphatase superfamily
APGEEAHD_00916 3e-256 rsmF 2.1.1.176, 2.1.1.178 J NOL1 NOP2 sun family protein
APGEEAHD_00917 3.3e-158 pstS P phosphate
APGEEAHD_00918 2.5e-156 pstC P probably responsible for the translocation of the substrate across the membrane
APGEEAHD_00919 1.2e-155 pstA P phosphate transport system permease
APGEEAHD_00920 1e-150 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
APGEEAHD_00921 1.7e-139 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
APGEEAHD_00922 2.4e-113 phoU P Plays a role in the regulation of phosphate uptake
APGEEAHD_00923 0.0 pepN 3.4.11.2 E aminopeptidase
APGEEAHD_00924 7e-195 xerS D Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division
APGEEAHD_00925 1.3e-187 lplA 6.3.1.20 H Lipoate-protein ligase
APGEEAHD_00926 3e-08
APGEEAHD_00927 6.2e-09
APGEEAHD_00928 0.0 glgP 2.4.1.1 GT35 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
APGEEAHD_00929 2.9e-303 malQ 2.4.1.25 GH77 G 4-alpha-glucanotransferase
APGEEAHD_00930 1e-23 L Transposase
APGEEAHD_00931 4.6e-25 tatA U protein secretion
APGEEAHD_00932 5.8e-121 tatC U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APGEEAHD_00933 5.3e-298 ywbL P COG0672 High-affinity Fe2 Pb2 permease
APGEEAHD_00934 1.6e-232 ycdB P peroxidase
APGEEAHD_00935 7.1e-153 ycdO P periplasmic lipoprotein involved in iron transport
APGEEAHD_00936 3e-34 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
APGEEAHD_00937 3.7e-85 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
APGEEAHD_00938 1.7e-60 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
APGEEAHD_00939 1.2e-65 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
APGEEAHD_00940 2.4e-134 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
APGEEAHD_00941 1.9e-37 3.5.1.28 NU amidase activity
APGEEAHD_00942 8.5e-266 3.5.1.28 NU amidase activity
APGEEAHD_00943 3.6e-82 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
APGEEAHD_00944 2.6e-20 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
APGEEAHD_00945 0.0 lpdA 1.8.1.4 C Dehydrogenase
APGEEAHD_00946 1.8e-198 acoC 2.3.1.12 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
APGEEAHD_00947 3.7e-182 acoB 1.2.4.1, 1.2.4.4 C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
APGEEAHD_00948 3e-184 acoA 1.2.4.1, 1.2.4.4 C Dehydrogenase E1 component
APGEEAHD_00949 0.0 S the current gene model (or a revised gene model) may contain a frame shift
APGEEAHD_00950 1.1e-234 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
APGEEAHD_00951 2.9e-127 ung 3.2.2.27 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
APGEEAHD_00952 1.1e-217 yeaB K Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
APGEEAHD_00953 1.2e-157 rssA S Phospholipase, patatin family
APGEEAHD_00954 1e-105 estA E Lysophospholipase L1 and related esterases
APGEEAHD_00955 4.5e-291 S unusual protein kinase
APGEEAHD_00956 4.9e-39 S granule-associated protein
APGEEAHD_00957 1.9e-33 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
APGEEAHD_00958 2.3e-33 bglH 3.2.1.86 GT1 G beta-glucosidase activity
APGEEAHD_00959 1.3e-96 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
APGEEAHD_00960 2.9e-27 bglH 3.2.1.86 GT1 G beta-glucosidase activity
APGEEAHD_00961 1.3e-17 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
APGEEAHD_00962 1.3e-199 S hmm pf01594
APGEEAHD_00963 3.6e-88 G Belongs to the phosphoglycerate mutase family
APGEEAHD_00964 1.2e-67 supH 3.1.3.102, 3.1.3.104 Q phosphatase activity
APGEEAHD_00965 1.1e-15 supH 3.1.3.102, 3.1.3.104 S Sucrose-6F-phosphate phosphohydrolase
APGEEAHD_00966 3.2e-93 V VanZ like family
APGEEAHD_00967 3.6e-117 L Transposase
APGEEAHD_00968 4.8e-117 devA 3.6.3.25 V abc transporter atp-binding protein
APGEEAHD_00969 2.8e-164 hrtB V MacB-like periplasmic core domain
APGEEAHD_00970 3.5e-28 3.4.13.21 I Protein conserved in bacteria
APGEEAHD_00971 9e-89 FNV0100 F Belongs to the Nudix hydrolase family
APGEEAHD_00972 4.2e-29 L transposition
APGEEAHD_00973 3e-13
APGEEAHD_00974 2.4e-30
APGEEAHD_00975 4.4e-24 L Transposase
APGEEAHD_00976 1.9e-46 L transposase activity
APGEEAHD_00977 4e-50 L Transposase
APGEEAHD_00978 3.8e-103 L Transposase
APGEEAHD_00979 0.0 ftsH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APGEEAHD_00980 3.4e-97 hpt 2.4.2.8, 6.3.4.19 F Belongs to the purine pyrimidine phosphoribosyltransferase family
APGEEAHD_00981 5e-240 tilS 2.4.2.8, 6.3.4.19 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
APGEEAHD_00982 1.3e-240 XK27_09285 3.5.2.6 V Beta-lactamase enzyme family
APGEEAHD_00984 2.7e-61 divIC D Septum formation initiator
APGEEAHD_00985 1.7e-39 yabO J Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
APGEEAHD_00986 0.0 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APGEEAHD_00987 1.4e-104 pth 3.1.1.29 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
APGEEAHD_00988 1.1e-203 ychF J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
APGEEAHD_00989 1.1e-29 yyzM S Protein conserved in bacteria
APGEEAHD_00990 6.3e-202 dnaN 2.7.7.7 L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
APGEEAHD_00991 1.3e-257 dnaA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APGEEAHD_00992 8.5e-134 parB K Belongs to the ParB family
APGEEAHD_00993 2.6e-193 htrA 3.4.21.107 O Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain'
APGEEAHD_00994 1.1e-86 rlmH 2.1.1.177 J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
APGEEAHD_00995 6.2e-120 yoaK S Psort location CytoplasmicMembrane, score
APGEEAHD_00999 0.0 XK27_10405 S Bacterial membrane protein YfhO
APGEEAHD_01000 6.7e-306 ybiT S abc transporter atp-binding protein
APGEEAHD_01001 4.2e-153 yvjA S membrane
APGEEAHD_01002 6.3e-193 trpS 6.1.1.2 J Tryptophanyl-tRNA synthetase
APGEEAHD_01003 4.3e-275 guaB 1.1.1.205 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
APGEEAHD_01004 5.9e-205 recF L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APGEEAHD_01005 1.6e-45 yaaA S S4 domain protein YaaA
APGEEAHD_01006 4.8e-235 ymfF S Peptidase M16
APGEEAHD_01007 3.1e-242 ymfH S Peptidase M16
APGEEAHD_01008 6.3e-138 ymfM S sequence-specific DNA binding
APGEEAHD_01009 3.1e-90 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
APGEEAHD_01010 1.5e-152 ecfA1 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
APGEEAHD_01011 5.2e-153 ecfA2 3.6.3.55 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
APGEEAHD_01012 2e-138 ecfT P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
APGEEAHD_01013 5.3e-85 lytE M LysM domain protein
APGEEAHD_01014 1.5e-88 isaA GH23 M Immunodominant staphylococcal antigen A
APGEEAHD_01015 0.0 S Bacterial membrane protein, YfhO
APGEEAHD_01016 8.6e-220 mnmA 2.8.1.13 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
APGEEAHD_01017 1.5e-77 F NUDIX domain
APGEEAHD_01018 0.0 gidA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
APGEEAHD_01019 0.0 yybT T signaling protein consisting of a modified GGDEF domain and a DHH domain
APGEEAHD_01020 3.9e-70 rplI J binds to the 23S rRNA
APGEEAHD_01021 1.5e-245 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
APGEEAHD_01022 8.2e-48 veg S Biofilm formation stimulator VEG
APGEEAHD_01023 9.8e-109 rpsD J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
APGEEAHD_01024 2.7e-08
APGEEAHD_01025 4.8e-55 ypaA M Membrane
APGEEAHD_01026 6.4e-96 XK27_06935 K transcriptional regulator
APGEEAHD_01027 2.5e-160 XK27_06930 V domain protein
APGEEAHD_01028 1.8e-88 S Putative adhesin
APGEEAHD_01029 1.8e-19 XK27_06920 S Protein of unknown function (DUF1700)
APGEEAHD_01031 1.7e-23 K negative regulation of transcription, DNA-templated
APGEEAHD_01032 4e-19 K negative regulation of transcription, DNA-templated
APGEEAHD_01033 3.4e-13 nudL L hydrolase
APGEEAHD_01034 1.1e-11 K CsbD-like
APGEEAHD_01035 3.1e-85 M Protein conserved in bacteria
APGEEAHD_01036 1.8e-23 S Small integral membrane protein
APGEEAHD_01037 9.1e-101
APGEEAHD_01038 1e-29 S Membrane
APGEEAHD_01040 2.5e-96 S Hydrophobic domain protein
APGEEAHD_01041 2.6e-49 yegS 2.7.1.107 I lipid kinase activity
APGEEAHD_01044 5.1e-184 sip L Belongs to the 'phage' integrase family
APGEEAHD_01045 5.9e-20 S MerR HTH family regulatory protein
APGEEAHD_01046 2.1e-82 S Plasmid replication protein
APGEEAHD_01047 2e-20
APGEEAHD_01048 3.6e-162 D COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins
APGEEAHD_01049 1.7e-35
APGEEAHD_01050 7.2e-10 S Sigma-70, region 4
APGEEAHD_01051 0.0 V Type II restriction enzyme, methylase subunits
APGEEAHD_01052 8.3e-29
APGEEAHD_01053 6.7e-19 rpmG J Belongs to the bacterial ribosomal protein bL33 family
APGEEAHD_01054 1e-24 rpmF J Belongs to the bacterial ribosomal protein bL32 family
APGEEAHD_01055 1.4e-36 metE 2.1.1.14 E Methionine synthase
APGEEAHD_01056 5.2e-55 metE 2.1.1.14 E Methionine synthase
APGEEAHD_01057 1.4e-53 metE 2.1.1.14 E Methionine synthase
APGEEAHD_01058 1.6e-241 hisS 6.1.1.21 J histidyl-tRNA synthetase
APGEEAHD_01060 0.0 aspS 6.1.1.12 J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
APGEEAHD_01061 9.9e-169 XK27_01785 S cog cog1284
APGEEAHD_01062 1.8e-147 yaaA S Belongs to the UPF0246 family
APGEEAHD_01063 3.7e-116 nrdG 1.97.1.4 O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APGEEAHD_01064 2.6e-91 XK27_10930 K acetyltransferase
APGEEAHD_01065 7.5e-14
APGEEAHD_01066 0.0 nrdD 1.1.98.6 F Ribonucleoside-triphosphate reductase
APGEEAHD_01067 2.3e-301 ccs S the current gene model (or a revised gene model) may contain a frame shift
APGEEAHD_01068 4.2e-44 yrzB S Belongs to the UPF0473 family
APGEEAHD_01069 1.2e-70 yqgF L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
APGEEAHD_01070 2.8e-44 yrzL S Belongs to the UPF0297 family
APGEEAHD_01071 8.4e-27 rpmB J Belongs to the bacterial ribosomal protein bL28 family
APGEEAHD_01072 5.2e-237 rarA L ATPase related to the helicase subunit of the Holliday junction resolvase
APGEEAHD_01074 8.5e-132 int L Belongs to the 'phage' integrase family
APGEEAHD_01075 2.5e-89 K sequence-specific DNA binding
APGEEAHD_01076 5.1e-287 V ABC transporter transmembrane region
APGEEAHD_01077 3.6e-232 C Radical SAM
APGEEAHD_01079 1.3e-128 Z012_04635 K sequence-specific DNA binding
APGEEAHD_01080 2.1e-280 V ABC transporter
APGEEAHD_01081 0.0 KLT serine threonine protein kinase
APGEEAHD_01082 3.4e-155 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
APGEEAHD_01084 5.9e-42 L Transposase
APGEEAHD_01085 8e-42 K Cold-Shock Protein
APGEEAHD_01086 5.4e-32 cspD K Cold shock protein domain
APGEEAHD_01087 6.4e-168 pepD E Dipeptidase
APGEEAHD_01088 8.7e-162 whiA K May be required for sporulation
APGEEAHD_01089 3.6e-182 ybhK S Required for morphogenesis under gluconeogenic growth conditions
APGEEAHD_01090 1.2e-163 rapZ S Displays ATPase and GTPase activities
APGEEAHD_01091 2.8e-137 yejC S cyclic nucleotide-binding protein
APGEEAHD_01092 2.2e-19 D nuclear chromosome segregation
APGEEAHD_01093 6.5e-95 queF 1.7.1.13 S Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily
APGEEAHD_01094 2.5e-135 queE 1.97.1.4, 4.3.99.3 H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
APGEEAHD_01095 5.7e-82 queD 4.1.2.50, 4.2.3.12 H synthase
APGEEAHD_01096 9.8e-123 queC 6.3.4.20 F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
APGEEAHD_01097 3e-63 tdcF 3.5.99.10 J endoribonuclease L-PSP
APGEEAHD_01098 1.6e-18 L Integrase core domain
APGEEAHD_01099 6.9e-229 L Transposase
APGEEAHD_01100 3.9e-52 rplL J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
APGEEAHD_01101 5.6e-78 rplJ J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
APGEEAHD_01102 1.1e-24 ytrF V efflux transmembrane transporter activity
APGEEAHD_01103 1.7e-07 V efflux transmembrane transporter activity
APGEEAHD_01104 8.8e-21 V permease protein
APGEEAHD_01105 1e-09 V permease protein
APGEEAHD_01106 1.6e-33 V permease protein
APGEEAHD_01107 4e-37 acrA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APGEEAHD_01108 2.2e-134 2.1.1.223 S Putative SAM-dependent methyltransferase
APGEEAHD_01109 0.0 carB 6.3.5.5 F carbamoyl-phosphate synthetase ammonia chain
APGEEAHD_01110 1.1e-211 carA 6.3.5.5 F carbamoyl-phosphate synthetase glutamine chain
APGEEAHD_01111 1e-173 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
APGEEAHD_01112 4.9e-227 pyrP F uracil Permease
APGEEAHD_01113 3.7e-88 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
APGEEAHD_01114 5e-162 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
APGEEAHD_01115 8.8e-78 lspA 3.4.23.36 MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APGEEAHD_01116 1.4e-167 fhuR K transcriptional regulator (lysR family)
APGEEAHD_01121 2.5e-23 L Transposase
APGEEAHD_01122 0.0 tkt 2.2.1.1 G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
APGEEAHD_01123 1.2e-146 cbiQ P cobalt transport
APGEEAHD_01124 0.0 ykoD P abc transporter atp-binding protein
APGEEAHD_01125 3.9e-93 S UPF0397 protein
APGEEAHD_01126 5.5e-158 salL 2.5.1.63, 2.5.1.94 S S-adenosyl-l-methionine hydroxide adenosyltransferase
APGEEAHD_01127 4.6e-211 sstT E Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
APGEEAHD_01128 3e-98 metI P ABC transporter (Permease
APGEEAHD_01129 1.5e-189 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APGEEAHD_01130 1e-63 dapE 3.5.1.18 E succinyl-diaminopimelate desuccinylase activity
APGEEAHD_01131 1.4e-62 dapE 3.5.1.18 E succinyl-diaminopimelate desuccinylase activity
APGEEAHD_01132 7.1e-86 dapE 3.5.1.18 E COG0624, acetylornithine deacetylase succinyl-diaminopimelate desuccinylase and related deacylases
APGEEAHD_01133 3.7e-165 metQ M Belongs to the NlpA lipoprotein family
APGEEAHD_01134 4e-153 ET amino acid transport
APGEEAHD_01135 3.8e-205 EGP Transmembrane secretion effector
APGEEAHD_01136 0.0 3.3.1.1, 3.6.1.55, 3.6.1.67 F NUDIX domain
APGEEAHD_01137 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
APGEEAHD_01138 1.2e-97 ET amino acid transport
APGEEAHD_01139 3e-36 ET amino acid transport
APGEEAHD_01140 1.6e-131 cbiO P ABC transporter
APGEEAHD_01141 1.7e-137 P cobalt transport protein
APGEEAHD_01142 2.7e-177 cbiM P PDGLE domain
APGEEAHD_01143 4.4e-160 ureD O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
APGEEAHD_01144 9.5e-112 ureG KO Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
APGEEAHD_01145 5.3e-130 ureF O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
APGEEAHD_01146 6.6e-78 ureE O enzyme active site formation
APGEEAHD_01147 0.0 ureC 3.5.1.5 E Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family
APGEEAHD_01148 7.8e-54 ureB 3.5.1.5 E Belongs to the urease beta subunit family
APGEEAHD_01149 7.6e-46 ureA 3.5.1.5 E Belongs to the urease gamma subunit family
APGEEAHD_01150 6.8e-95 ureI S AmiS/UreI family transporter
APGEEAHD_01151 9.2e-132 S Domain of unknown function (DUF4173)
APGEEAHD_01152 6.7e-36 S Domain of unknown function (DUF4173)
APGEEAHD_01153 3.7e-51 yhaI L Membrane
APGEEAHD_01154 3.4e-68 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
APGEEAHD_01155 1.6e-25 V protein secretion by the type I secretion system
APGEEAHD_01156 4.3e-57 V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
APGEEAHD_01157 7.4e-36 V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
APGEEAHD_01158 1.2e-32 V protein secretion by the type I secretion system
APGEEAHD_01159 5.6e-161 K sequence-specific DNA binding
APGEEAHD_01160 2.4e-113 bcrC 3.6.1.27 I Membrane-associated phospholipid phosphatase
APGEEAHD_01161 3.9e-88 ribU U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
APGEEAHD_01162 2.7e-96 trmL 2.1.1.207 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
APGEEAHD_01163 1.5e-247 trkA P Potassium transporter peripheral membrane component
APGEEAHD_01164 1.2e-258 trkH P Cation transport protein
APGEEAHD_01165 1.2e-39 yidD S Could be involved in insertion of integral membrane proteins into the membrane
APGEEAHD_01166 6.1e-140 rluB 5.4.99.19, 5.4.99.21, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
APGEEAHD_01167 3e-99 scpB D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
APGEEAHD_01168 3.8e-120 scpA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
APGEEAHD_01169 4.5e-135 xerD L tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site
APGEEAHD_01170 7.8e-85 ykuL S CBS domain
APGEEAHD_01171 3.5e-99 XK27_09740 S Phosphoesterase
APGEEAHD_01172 7.8e-185 rdgB 3.6.1.66, 5.1.1.3 F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APGEEAHD_01173 3.8e-148 murI 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
APGEEAHD_01174 7.6e-36 yneF S UPF0154 protein
APGEEAHD_01175 3.7e-91 K transcriptional regulator
APGEEAHD_01176 2.8e-243 lysA 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
APGEEAHD_01179 8.8e-98 ybhL S Belongs to the BI1 family
APGEEAHD_01180 6.1e-93 XK27_09705 6.1.1.14 S HD superfamily hydrolase
APGEEAHD_01181 8.4e-131 spoU 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APGEEAHD_01182 7e-46 acyP 3.6.1.7 C Belongs to the acylphosphatase family
APGEEAHD_01183 2.9e-165 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
APGEEAHD_01184 5.2e-59 L Integrase core domain protein
APGEEAHD_01185 1.6e-77 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
APGEEAHD_01186 0.0 mltG ADL Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
APGEEAHD_01187 7.3e-80 XK27_09675 K -acetyltransferase
APGEEAHD_01188 2.6e-255 mpl 6.3.2.4, 6.3.2.45, 6.3.2.8 M Belongs to the MurCDEF family
APGEEAHD_01189 2.5e-23
APGEEAHD_01190 0.0 snf 2.7.11.1 L Superfamily II DNA RNA helicases, SNF2 family'
APGEEAHD_01191 4.7e-295 mapZ D Early cell division protein that marks the future cell division site and supports proper FtsZ ring positioning
APGEEAHD_01192 1.5e-222 rlmL 2.1.1.173, 2.1.1.264 L Belongs to the methyltransferase superfamily
APGEEAHD_01193 2.5e-50 gpsB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
APGEEAHD_01194 3.1e-95 ypsA S Belongs to the UPF0398 family
APGEEAHD_01195 7.3e-109 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
APGEEAHD_01196 0.0 ponA 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
APGEEAHD_01197 5.2e-119 gluP 3.4.21.105 O membrane protein (homolog of Drosophila rhomboid)
APGEEAHD_01198 9.1e-95 ygfA 6.3.3.2 H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APGEEAHD_01199 7.9e-221 hipO 3.5.1.47 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
APGEEAHD_01200 8.1e-59 dapD 2.3.1.117, 2.3.1.89 E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
APGEEAHD_01201 9.8e-35 S glycolate biosynthetic process
APGEEAHD_01202 2.5e-62 S phosphatase activity
APGEEAHD_01203 2.4e-158 rrmA 2.1.1.187 Q methyltransferase
APGEEAHD_01206 2.7e-91 tadA 3.5.4.1, 3.5.4.33 FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
APGEEAHD_01207 5.1e-66 ssb_2 L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
APGEEAHD_01208 4.1e-36 yeeD O sulfur carrier activity
APGEEAHD_01209 2.8e-188 yeeE S Sulphur transport
APGEEAHD_01210 6.7e-113 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
APGEEAHD_01211 2.1e-54 ytpP 2.7.1.180, 5.3.4.1 CO Thioredoxin
APGEEAHD_01212 1.8e-09 S Domain of unknown function (DUF4651)
APGEEAHD_01213 2e-205 pepA 3.4.11.7 G COG1363 Cellulase M and related proteins
APGEEAHD_01214 3.9e-131 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
APGEEAHD_01215 1.8e-111 S CAAX amino terminal protease family protein
APGEEAHD_01217 5e-67 V CAAX protease self-immunity
APGEEAHD_01218 1.4e-33 V CAAX protease self-immunity
APGEEAHD_01219 8.8e-27 lanR K sequence-specific DNA binding
APGEEAHD_01220 2.9e-221 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
APGEEAHD_01221 5.9e-177 ytxK 2.1.1.72 L DNA methylase
APGEEAHD_01222 6.8e-13 comGF U Putative Competence protein ComGF
APGEEAHD_01223 4e-72 comGF U Competence protein ComGF
APGEEAHD_01224 1.4e-15 NU Type II secretory pathway pseudopilin
APGEEAHD_01225 4e-57 cglD NU Competence protein
APGEEAHD_01226 8.5e-43 comGC U Required for transformation and DNA binding
APGEEAHD_01227 1.8e-156 cglB U protein transport across the cell outer membrane
APGEEAHD_01228 2.1e-174 comGA NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APGEEAHD_01229 1e-68 S cog cog4699
APGEEAHD_01230 0.0 rpoC 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APGEEAHD_01231 0.0 rpoB 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APGEEAHD_01232 0.0 pbp1B 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
APGEEAHD_01233 9.3e-239 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
APGEEAHD_01234 1.6e-196 ilvC 1.1.1.86 H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
APGEEAHD_01235 7.7e-77 ilvN 2.2.1.6 E Acetolactate synthase
APGEEAHD_01236 0.0 ilvB 2.2.1.6 EH Acetolactate synthase
APGEEAHD_01237 0.0 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
APGEEAHD_01238 7.6e-305 yloV S kinase related to dihydroxyacetone kinase
APGEEAHD_01239 1.8e-57 asp S cog cog1302
APGEEAHD_01240 3.2e-226 norN V Mate efflux family protein
APGEEAHD_01241 6.4e-279 thrC 4.2.3.1 E Threonine synthase
APGEEAHD_01242 3.2e-65 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
APGEEAHD_01243 1.2e-35 adhE 1.1.1.1, 1.2.1.10 C hydroxyacid-oxoacid transhydrogenase activity
APGEEAHD_01244 3.5e-76 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
APGEEAHD_01245 1.3e-135 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
APGEEAHD_01246 1.4e-63 adhE 1.1.1.1, 1.2.1.10 C Dehydrogenase
APGEEAHD_01247 0.0 pepO 3.4.24.71 O Peptidase family M13
APGEEAHD_01248 2.8e-38 treC 3.2.1.93 GH13 G COG0366 Glycosidases
APGEEAHD_01249 1.2e-69 treC 3.2.1.93 GH13 G COG0366 Glycosidases
APGEEAHD_01250 5.9e-66 treC 3.2.1.93 GH13 G COG0366 Glycosidases
APGEEAHD_01251 1.4e-54 treB 2.7.1.201 G PTS System
APGEEAHD_01252 5.8e-21 treR K DNA-binding transcription factor activity
APGEEAHD_01253 8.6e-87 treR K trehalose operon
APGEEAHD_01254 3.3e-95 ywlG S Belongs to the UPF0340 family
APGEEAHD_01257 2.7e-13 L PFAM Integrase, catalytic core
APGEEAHD_01258 1.9e-72 L PFAM Integrase, catalytic core
APGEEAHD_01259 1.8e-164 fba 4.1.2.13, 4.1.2.29 G aldolase
APGEEAHD_01261 6.7e-110 6.3.2.2 H ergothioneine biosynthetic process
APGEEAHD_01262 3.6e-64 6.3.2.2 H gamma-glutamylcysteine synthetase
APGEEAHD_01263 7.2e-12 6.3.2.2 H gamma-glutamylcysteine synthetase
APGEEAHD_01264 5.5e-11 L PFAM Integrase, catalytic core
APGEEAHD_01265 1.8e-111 L PFAM Integrase, catalytic core
APGEEAHD_01266 3.3e-62 rplQ J ribosomal protein l17
APGEEAHD_01267 4.8e-171 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APGEEAHD_01268 9.6e-62 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APGEEAHD_01269 4e-57 rpsM J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APGEEAHD_01270 6e-15 rpmJ J Belongs to the bacterial ribosomal protein bL36 family
APGEEAHD_01271 2.7e-32 infA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
APGEEAHD_01272 9.2e-121 adk 2.7.4.3 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
APGEEAHD_01273 9.6e-231 secY U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
APGEEAHD_01274 4.4e-58 rplO J binds to the 23S rRNA
APGEEAHD_01275 2.5e-23 rpmD J ribosomal protein l30
APGEEAHD_01276 1.7e-79 rpsE J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
APGEEAHD_01277 1.9e-56 rplR J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
APGEEAHD_01278 2.3e-93 rplF J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
APGEEAHD_01279 1.2e-67 rpsH J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
APGEEAHD_01280 1.5e-28 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APGEEAHD_01281 1.6e-94 rplE J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APGEEAHD_01282 1.4e-47 rplX J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
APGEEAHD_01283 1.1e-59 rplN J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
APGEEAHD_01284 6e-39 rpsQ J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
APGEEAHD_01285 2.7e-26 rpmC J Belongs to the universal ribosomal protein uL29 family
APGEEAHD_01286 7.2e-71 rplP J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
APGEEAHD_01287 2.1e-117 rpsC J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
APGEEAHD_01288 7.3e-53 rplV J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
APGEEAHD_01289 4.9e-47 rpsS J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
APGEEAHD_01290 8.8e-153 rplB J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
APGEEAHD_01291 2.4e-44 rplW J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
APGEEAHD_01292 5.7e-104 rplD J Forms part of the polypeptide exit tunnel
APGEEAHD_01293 1.1e-110 rplC J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
APGEEAHD_01294 1.3e-48 rpsJ J Involved in the binding of tRNA to the ribosomes
APGEEAHD_01295 7.8e-188 ruvB 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
APGEEAHD_01296 0.0 XK27_09800 I Acyltransferase
APGEEAHD_01297 1.7e-35 XK27_09805 S MORN repeat protein
APGEEAHD_01298 1e-80 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
APGEEAHD_01299 4.1e-250 purA 6.3.4.4 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
APGEEAHD_01300 8.8e-83 adk 2.7.4.3 F topology modulation protein
APGEEAHD_01301 3.1e-172 yxaM EGP Major facilitator Superfamily
APGEEAHD_01302 1.9e-197 2.7.7.73, 2.7.7.80 H Involved in molybdopterin and thiamine biosynthesis, family 2
APGEEAHD_01303 7.8e-28 L transposase activity
APGEEAHD_01304 8.6e-232 serS 6.1.1.11 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
APGEEAHD_01305 4.2e-62 manO S protein conserved in bacteria
APGEEAHD_01306 6.2e-168 manN G PTS system mannose fructose sorbose family IID component
APGEEAHD_01307 2.3e-116 manM G pts system
APGEEAHD_01308 1.1e-181 manL 2.7.1.191 G pts system
APGEEAHD_01309 1.5e-140 XK27_00940 1.2.1.70, 3.5.1.9 S Metal-dependent hydrolase
APGEEAHD_01310 1e-153 yitU 3.1.3.104 S hydrolases of the HAD superfamily
APGEEAHD_01311 1.9e-248 pbuO S permease
APGEEAHD_01312 1.4e-77 ydiB 2.7.1.221, 5.1.1.1 M ATPase or kinase
APGEEAHD_01313 2.4e-92 XK27_05885 2.3.1.82 M Acetyltransferase GNAT Family
APGEEAHD_01314 2.5e-220 brpA K Transcriptional
APGEEAHD_01315 3.9e-81 rimP S Required for maturation of 30S ribosomal subunits
APGEEAHD_01316 3.1e-212 nusA K Participates in both transcription termination and antitermination
APGEEAHD_01317 1e-47 ylxR K Nucleic-acid-binding protein implicated in transcription termination
APGEEAHD_01318 1.4e-41 ylxQ J ribosomal protein
APGEEAHD_01319 0.0 infB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
APGEEAHD_01320 1.7e-57 rbfA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
APGEEAHD_01321 4.4e-22 yvdD 3.2.2.10 S Belongs to the LOG family
APGEEAHD_01322 3.4e-37 yvdD 3.2.2.10 L Belongs to the LOG family
APGEEAHD_01324 2.1e-213 femA 2.3.2.10, 2.3.2.16, 2.3.2.17, 2.3.2.18 V protein involved in methicillin resistance
APGEEAHD_01325 4.9e-276 murE 6.3.2.13, 6.3.2.7 M to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APGEEAHD_01326 4.5e-283 ytgP S Membrane protein involved in the export of O-antigen and teichoic acid
APGEEAHD_01327 6e-89 pacL 3.6.3.8, 3.6.3.9 P cation transport ATPase
APGEEAHD_01328 4.7e-202 metB 2.5.1.48, 4.4.1.8 E cystathionine
APGEEAHD_01329 1e-223 malY 4.4.1.8 E COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
APGEEAHD_01332 4.4e-112 upp 2.4.2.9 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
APGEEAHD_01333 2.9e-105 clpP 3.4.21.92 OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
APGEEAHD_01334 1.2e-74 ylbF S Belongs to the UPF0342 family
APGEEAHD_01335 7.1e-46 ylbG S UPF0298 protein
APGEEAHD_01336 1.3e-210 livJ E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component
APGEEAHD_01337 1.9e-145 livH E Belongs to the binding-protein-dependent transport system permease family
APGEEAHD_01338 1.4e-138 livM E Belongs to the binding-protein-dependent transport system permease family
APGEEAHD_01339 9.6e-138 livG E COG0411 ABC-type branched-chain amino acid transport systems, ATPase component
APGEEAHD_01340 4.8e-123 livF E COG0410 ABC-type branched-chain amino acid transport systems, ATPase component
APGEEAHD_01341 6.8e-69 acuB S IMP dehydrogenase activity
APGEEAHD_01342 8.9e-41 acuB S IMP dehydrogenase activity
APGEEAHD_01343 1.1e-167 cysK 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
APGEEAHD_01344 6.3e-111 yvyE 3.4.13.9 S YigZ family
APGEEAHD_01345 4.5e-252 comFA L Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
APGEEAHD_01346 1.7e-122 comFC S Competence protein
APGEEAHD_01347 2.1e-94 hpf J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
APGEEAHD_01348 1.6e-77 sigH K DNA-templated transcription, initiation
APGEEAHD_01349 9.3e-150 ykuT M mechanosensitive ion channel
APGEEAHD_01350 6.4e-219 tig D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
APGEEAHD_01351 4.8e-73 rpoE K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
APGEEAHD_01352 7.6e-310 pyrG 6.3.4.2 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
APGEEAHD_01353 1.3e-84 XK27_03960 S Protein of unknown function (DUF3013)
APGEEAHD_01354 3.7e-81 mutT3 3.6.1.13, 3.6.1.55 L NUDIX domain
APGEEAHD_01355 1.1e-178 prmA J Ribosomal protein L11 methyltransferase
APGEEAHD_01356 4.4e-135 rsmE 2.1.1.193 J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
APGEEAHD_01357 1.4e-42 F nucleotide catabolic process
APGEEAHD_01358 5.4e-139 cpdB 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
APGEEAHD_01359 7.7e-140 cpdB 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
APGEEAHD_01360 2.3e-51 cpdB 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
APGEEAHD_01361 1.8e-83 nrdI F Belongs to the NrdI family
APGEEAHD_01362 0.0 relA 2.7.6.5 KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APGEEAHD_01363 2.3e-75 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
APGEEAHD_01364 1.4e-09 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
APGEEAHD_01365 2e-27 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
APGEEAHD_01366 2.1e-58 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
APGEEAHD_01367 1.9e-45 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
APGEEAHD_01368 1.7e-237 ilvA 4.3.1.19 E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APGEEAHD_01369 3.3e-112 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
APGEEAHD_01370 5.3e-113 fnr5 K Catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
APGEEAHD_01371 9.3e-201 yhjX P Major Facilitator
APGEEAHD_01372 9.2e-43 rpsO J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
APGEEAHD_01373 5e-94 V VanZ like family
APGEEAHD_01375 1e-123 glnQ E abc transporter atp-binding protein
APGEEAHD_01376 8.4e-274 glnP P ABC transporter
APGEEAHD_01377 9.1e-153 uppP 3.6.1.27 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
APGEEAHD_01378 2.3e-136 mecA NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
APGEEAHD_01379 1.1e-185 tagO 2.7.8.33, 2.7.8.35 M transferase
APGEEAHD_01380 9.5e-144 sufC O ABC-type transport system involved in Fe-S cluster assembly, ATPase component
APGEEAHD_01381 6.3e-235 sufD O assembly protein SufD
APGEEAHD_01382 2.7e-238 sufS 2.8.1.7, 4.4.1.16 E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APGEEAHD_01383 1.1e-74 nifU C SUF system FeS assembly protein, NifU family
APGEEAHD_01384 3.5e-274 sufB O assembly protein SufB
APGEEAHD_01385 4.6e-18 oppA E ABC transporter substrate-binding protein
APGEEAHD_01386 1.3e-137 oppA E ABC transporter substrate-binding protein
APGEEAHD_01387 3.6e-42 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
APGEEAHD_01388 1.1e-32 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
APGEEAHD_01389 7e-60 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
APGEEAHD_01390 3e-27 oppD P Belongs to the ABC transporter superfamily
APGEEAHD_01391 2.5e-32 oppD P Belongs to the ABC transporter superfamily
APGEEAHD_01392 1.2e-62 oppD P Belongs to the ABC transporter superfamily
APGEEAHD_01393 1.6e-42 oppD P Belongs to the ABC transporter superfamily
APGEEAHD_01394 7.5e-62 oppF P Belongs to the ABC transporter superfamily
APGEEAHD_01395 3.4e-62 oppF P Belongs to the ABC transporter superfamily
APGEEAHD_01396 8.3e-23
APGEEAHD_01397 1.1e-161 hslO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
APGEEAHD_01398 7.4e-183 dus J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APGEEAHD_01399 1.9e-223 EGP Major facilitator Superfamily
APGEEAHD_01400 9.1e-72 adcR K transcriptional
APGEEAHD_01401 3.2e-135 adcC P ABC transporter, ATP-binding protein
APGEEAHD_01402 2.8e-127 adcB P ABC transporter (Permease
APGEEAHD_01403 2.1e-163 mleP2 S Transporter, auxin efflux carrier (AEC) family protein
APGEEAHD_01404 0.0 ptsG 2.7.1.199, 2.7.1.208 G pts system
APGEEAHD_01405 9.8e-157 rgfB 3.1.3.90 L Endonuclease/Exonuclease/phosphatase family
APGEEAHD_01406 2.4e-256 pgi 5.3.1.9 G Belongs to the GPI family
APGEEAHD_01407 1.9e-127 yeeN K transcriptional regulatory protein
APGEEAHD_01408 2.4e-48 yajC U protein transport
APGEEAHD_01409 5.3e-141 uppS 2.5.1.31 H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APGEEAHD_01410 5e-145 cdsA 2.7.7.41 S Belongs to the CDS family
APGEEAHD_01411 1.4e-231 rseP 3.4.21.107, 3.4.21.116 M zinc metalloprotease
APGEEAHD_01412 0.0 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
APGEEAHD_01413 0.0 WQ51_06230 S ABC transporter substrate binding protein
APGEEAHD_01414 5.2e-142 cmpC S abc transporter atp-binding protein
APGEEAHD_01415 1.3e-42 groS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
APGEEAHD_01416 4.1e-287 groL O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
APGEEAHD_01417 4.4e-37 L Transposase
APGEEAHD_01418 6.4e-18 L transposase activity
APGEEAHD_01419 3.7e-44 L Transposase
APGEEAHD_01420 2.1e-203 metK 2.5.1.6 H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
APGEEAHD_01421 4.2e-175 birA 6.3.4.15 HK Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
APGEEAHD_01422 9.2e-295 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APGEEAHD_01423 1.6e-88 ytsP 1.8.4.14 T GAF domain-containing protein
APGEEAHD_01424 1.9e-164 miaA 2.5.1.75 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
APGEEAHD_01425 1.9e-20 WQ51_02665 S Protein of unknown function (DUF3042)
APGEEAHD_01426 5.8e-80
APGEEAHD_01428 1.1e-56 rplS J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
APGEEAHD_01429 6.1e-219 XK27_05110 P chloride
APGEEAHD_01430 8.7e-41 pheA 1.3.1.12, 2.3.1.79, 4.2.1.51, 5.4.99.5 E Chorismate mutase
APGEEAHD_01431 1.3e-282 clcA P Chloride transporter, ClC family
APGEEAHD_01432 2.3e-75 fld C Flavodoxin
APGEEAHD_01433 5.5e-14 XK27_08880
APGEEAHD_01434 4.7e-126 XK27_08875 O Zinc-dependent metalloprotease
APGEEAHD_01435 2e-151 estA CE1 S Putative esterase
APGEEAHD_01436 1.9e-308 rnjB S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
APGEEAHD_01437 4.4e-135 XK27_08845 S abc transporter atp-binding protein
APGEEAHD_01438 2e-147 XK27_08840 S Belongs to the binding-protein-dependent transport system permease family
APGEEAHD_01439 1.2e-175 XK27_08835 S ABC transporter substrate binding protein
APGEEAHD_01440 3.2e-17 S Domain of unknown function (DUF4649)
APGEEAHD_01442 8.1e-42 Q the current gene model (or a revised gene model) may contain a frame shift
APGEEAHD_01443 2.7e-26 Q the current gene model (or a revised gene model) may contain a frame shift
APGEEAHD_01444 3.2e-09 Q the current gene model (or a revised gene model) may contain a frame shift
APGEEAHD_01445 3.5e-238 L Transposase
APGEEAHD_01446 4.1e-41 L transposase activity
APGEEAHD_01447 1.3e-22 XK27_08085
APGEEAHD_01448 5.6e-92 XK27_08080 3.1.1.53 G Exopolysaccharide biosynthesis protein
APGEEAHD_01449 2.3e-09 XK27_08080 3.1.1.53 G Exopolysaccharide biosynthesis protein
APGEEAHD_01450 2e-140 hisK 3.1.3.15 E Histidinol phosphatase and related hydrolases of the PHP family
APGEEAHD_01451 1.1e-121 ylfI S tigr01906
APGEEAHD_01452 5.9e-143 nagD 2.7.1.25, 3.1.3.41 G Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
APGEEAHD_01453 6.7e-144 fat 3.1.2.21 I Acyl-ACP thioesterase
APGEEAHD_01454 4.1e-217 hemN H Involved in the biosynthesis of porphyrin-containing compound
APGEEAHD_01457 2.5e-205 rfbB 4.2.1.46 M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
APGEEAHD_01458 8.3e-113 rmlC 1.1.1.133, 5.1.3.13 M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
APGEEAHD_01459 1.9e-161 rfbA 2.7.7.24 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
APGEEAHD_01460 1.1e-206 yurR 1.4.5.1 E oxidoreductase
APGEEAHD_01461 5.7e-102 zupT P Mediates zinc uptake. May also transport other divalent cations
APGEEAHD_01462 9.6e-149 yqfO 3.5.4.16 S Belongs to the GTP cyclohydrolase I type 2 NIF3 family
APGEEAHD_01463 2.7e-123 trmK 2.1.1.217 S SAM-dependent methyltransferase
APGEEAHD_01464 1.7e-70 gtrA S GtrA-like protein
APGEEAHD_01465 1.5e-250 glmM 5.4.2.10 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APGEEAHD_01466 6e-169 ybbR S Protein conserved in bacteria
APGEEAHD_01467 5.6e-124 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
APGEEAHD_01468 7.5e-255 murD 3.4.21.10, 6.3.2.13, 6.3.2.9 M Mur ligase, middle domain protein
APGEEAHD_01469 8.7e-150 cobQ S glutamine amidotransferase
APGEEAHD_01470 0.0 mprF 2.3.2.3 J Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
APGEEAHD_01471 2.2e-131 pip 1.11.1.10 S Alpha beta hydrolase
APGEEAHD_01472 0.0 uup S abc transporter atp-binding protein
APGEEAHD_01473 2.1e-114 udk 2.7.1.48 F Cytidine monophosphokinase
APGEEAHD_01474 2.1e-178 yfmL 3.6.4.13 L DEAD DEAH box helicase
APGEEAHD_01475 2.1e-28 6.3.2.2, 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
APGEEAHD_01476 8.6e-265 gapN 1.2.1.9 C Belongs to the aldehyde dehydrogenase family
APGEEAHD_01477 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APGEEAHD_01478 3.9e-38 ptsH G phosphocarrier protein Hpr
APGEEAHD_01479 1.5e-222 icd 1.1.1.42 C Isocitrate dehydrogenase
APGEEAHD_01480 5.1e-212 citZ 2.3.3.1 C Belongs to the citrate synthase family
APGEEAHD_01481 0.0 acnA 4.2.1.3 C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
APGEEAHD_01482 2.2e-34 nrdH O Glutaredoxin
APGEEAHD_01483 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APGEEAHD_01484 1.7e-184 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APGEEAHD_01486 1e-36 L Transposase (IS116 IS110 IS902 family)
APGEEAHD_01487 1.5e-26 L Transposase (IS116 IS110 IS902 family)
APGEEAHD_01488 5.3e-165 ypuA S secreted protein
APGEEAHD_01489 8.3e-51 yaeR E COG0346 LactoylglutaTHIone lyase and related lyases
APGEEAHD_01490 2.1e-132 srtA 3.4.22.70 M Sortase (surface protein transpeptidase)
APGEEAHD_01491 0.0 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APGEEAHD_01492 1.1e-181 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
APGEEAHD_01493 3.4e-258 noxE P NADH oxidase
APGEEAHD_01494 1.9e-294 yfmM S abc transporter atp-binding protein
APGEEAHD_01495 3.3e-82 XK27_01265 S ECF-type riboflavin transporter, S component
APGEEAHD_01496 8.7e-85 pdxK 2.7.1.35 H Belongs to the pyridoxine kinase family
APGEEAHD_01497 4.5e-44 pdxK 2.7.1.35 H Belongs to the pyridoxine kinase family
APGEEAHD_01498 2e-86 S ECF-type riboflavin transporter, S component
APGEEAHD_01500 5e-240 XK27_08130 K Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
APGEEAHD_01501 2e-55 nrdD_1 1.1.98.6, 1.17.4.1 F Ribonucleoside-triphosphate reductase
APGEEAHD_01504 0.0 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
APGEEAHD_01505 9.9e-94 paiA 2.3.1.57 K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
APGEEAHD_01506 1.1e-197 pheS 6.1.1.20 J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
APGEEAHD_01507 0.0 smc D Required for chromosome condensation and partitioning
APGEEAHD_01508 8.4e-125 rnc 3.1.26.3 J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
APGEEAHD_01509 6.6e-173 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APGEEAHD_01510 5.2e-198 asd 1.2.1.11 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APGEEAHD_01511 1.6e-91 pat 2.3.1.183 M acetyltransferase
APGEEAHD_01512 0.0 M family 8
APGEEAHD_01513 2.7e-09
APGEEAHD_01514 5.8e-109 MA20_06410 E LysE type translocator
APGEEAHD_01515 2.7e-12 IQ PFAM AMP-dependent synthetase and ligase
APGEEAHD_01516 5.3e-12 IQ PFAM AMP-dependent synthetase and ligase
APGEEAHD_01517 1e-137
APGEEAHD_01518 1.8e-270 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APGEEAHD_01519 4.5e-61
APGEEAHD_01520 9.3e-72 S Signal peptide protein, YSIRK family
APGEEAHD_01521 1.4e-54 K response regulator
APGEEAHD_01522 1.1e-37 BP1961 P nitric oxide dioxygenase activity
APGEEAHD_01524 3.6e-282 XK27_07020 S Belongs to the UPF0371 family
APGEEAHD_01525 1.7e-179 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
APGEEAHD_01526 6.8e-161 yvgN C reductase
APGEEAHD_01527 3e-102 yoaK S Protein of unknown function (DUF1275)
APGEEAHD_01528 1.4e-110 drgA C Nitroreductase
APGEEAHD_01529 3.3e-231 pts13C G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
APGEEAHD_01530 8.6e-159 E Alpha/beta hydrolase of unknown function (DUF915)
APGEEAHD_01531 4.7e-76 ywnA K Transcriptional regulator
APGEEAHD_01532 9.5e-150 1.13.11.2 S glyoxalase
APGEEAHD_01533 5.1e-110 XK27_02070 S nitroreductase
APGEEAHD_01534 1.8e-227 yfnA E amino acid
APGEEAHD_01535 4.8e-25 csbD K CsbD-like
APGEEAHD_01536 8.2e-57 manA 5.3.1.8 G mannose-6-phosphate isomerase
APGEEAHD_01537 9.4e-65 manA 5.3.1.8 G mannose-6-phosphate isomerase
APGEEAHD_01538 1.7e-235 brnQ E Component of the transport system for branched-chain amino acids
APGEEAHD_01539 9e-186 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APGEEAHD_01540 2.6e-247 norM V Multidrug efflux pump
APGEEAHD_01541 9.2e-119 pbuX F xanthine permease
APGEEAHD_01542 3.3e-69 pbuX F xanthine permease
APGEEAHD_01543 2e-77 xpt 2.4.2.22, 2.4.2.7 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
APGEEAHD_01544 4.6e-123 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
APGEEAHD_01545 6.2e-166 T Histidine kinase
APGEEAHD_01546 1.9e-133 macB2 V ABC transporter, ATP-binding protein
APGEEAHD_01547 0.0 V ABC transporter (permease)
APGEEAHD_01548 4.7e-93 XK27_05000 S Fe-S-cluster oxidoreductase
APGEEAHD_01549 2.6e-30 liaI KT membrane
APGEEAHD_01550 1.4e-15 liaI KT membrane
APGEEAHD_01551 6.1e-26 XK27_09825 V 'abc transporter, ATP-binding protein
APGEEAHD_01552 3.7e-122 S An automated process has identified a potential problem with this gene model
APGEEAHD_01554 4.6e-42 3.6.1.55 F NUDIX domain
APGEEAHD_01555 1.2e-152 mutR K Transcriptional activator, Rgg GadR MutR family
APGEEAHD_01556 0.0 2.7.7.73, 2.7.7.80 E metalloendopeptidase activity
APGEEAHD_01557 1.5e-212 EGP Major facilitator Superfamily
APGEEAHD_01561 9.7e-158 XK27_09825 V abc transporter atp-binding protein
APGEEAHD_01562 1.4e-133 yvfS V ABC-2 type transporter
APGEEAHD_01563 1.5e-192 desK 2.7.13.3 T Histidine kinase
APGEEAHD_01564 4.4e-101 desR K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
APGEEAHD_01565 3.6e-97 S transport system, permease component
APGEEAHD_01566 3.5e-33 S transport system, permease component
APGEEAHD_01567 1.1e-144 S ABC-2 family transporter protein
APGEEAHD_01568 7.4e-26
APGEEAHD_01569 9e-102 sdaAA 4.3.1.17 E L-serine dehydratase
APGEEAHD_01570 3.4e-29 sdaAA 4.3.1.17 E L-serine dehydratase
APGEEAHD_01571 1.4e-121 sdaAB 4.3.1.17 E L-serine dehydratase
APGEEAHD_01572 1.8e-127 yjjG 3.1.3.102, 3.1.3.104, 3.1.3.5, 3.8.1.2 E hydrolase
APGEEAHD_01573 0.0 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
APGEEAHD_01574 9e-278 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APGEEAHD_01575 3.6e-230 dltD M Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
APGEEAHD_01576 1.7e-35 dltC 6.1.1.13 IQ Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
APGEEAHD_01577 3.9e-237 dltB M Membrane protein involved in D-alanine export
APGEEAHD_01578 1.4e-297 dltA 6.1.1.13 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
APGEEAHD_01579 1.7e-09 S D-Ala-teichoic acid biosynthesis protein
APGEEAHD_01580 0.0 XK27_10035 V abc transporter atp-binding protein
APGEEAHD_01581 0.0 yfiB1 V abc transporter atp-binding protein
APGEEAHD_01582 8e-100 pvaA M lytic transglycosylase activity
APGEEAHD_01583 1.2e-177 ndpA S 37-kD nucleoid-associated bacterial protein
APGEEAHD_01584 1.2e-233 glyA 2.1.2.1 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
APGEEAHD_01585 9.7e-109 ywlC 2.7.7.87, 3.1.3.48 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
APGEEAHD_01586 1.2e-154 prmB 2.1.1.297, 2.1.1.298 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
APGEEAHD_01587 3e-193 prfA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
APGEEAHD_01588 4.5e-111 tdk 2.7.1.21 F thymidine kinase
APGEEAHD_01589 4.6e-188 add 3.5.4.4 F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
APGEEAHD_01590 8.9e-155 gst O Glutathione S-transferase
APGEEAHD_01591 1e-184 nrnA 3.1.13.3, 3.1.3.7 S domain protein
APGEEAHD_01592 9.8e-177 apbE 2.7.1.180 H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
APGEEAHD_01593 2e-45 rpmE2 J 50S ribosomal protein L31
APGEEAHD_01594 3.2e-231 mntH P Mn2 and Fe2 transporters of the NRAMP family
APGEEAHD_01595 1.1e-09
APGEEAHD_01596 5.5e-30
APGEEAHD_01597 0.0 ileS 6.1.1.5 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
APGEEAHD_01598 1.8e-135 divIVA D Cell division protein DivIVA
APGEEAHD_01599 6.1e-143 ylmH T S4 RNA-binding domain
APGEEAHD_01600 2e-34 yggT D integral membrane protein
APGEEAHD_01601 6.8e-96 sepF D cell septum assembly
APGEEAHD_01602 2.3e-122 ylmE S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
APGEEAHD_01603 5.4e-237 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
APGEEAHD_01604 8e-252 ftsA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
APGEEAHD_01605 1.8e-177 divIB D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
APGEEAHD_01606 1e-201 murG 2.4.1.227 GT28 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
APGEEAHD_01607 1.6e-252 murD 6.3.2.9 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
APGEEAHD_01609 0.0 typA T GTP-binding protein TypA
APGEEAHD_01610 2.2e-179 glk 2.7.1.2 G Glucokinase
APGEEAHD_01611 8.4e-28 yqgQ S protein conserved in bacteria
APGEEAHD_01612 1.1e-80 perR P Belongs to the Fur family
APGEEAHD_01613 3.5e-91 dps P Belongs to the Dps family
APGEEAHD_01614 1.3e-114 pilD 3.4.23.43 NOU Bacterial Peptidase A24 N-terminal domain
APGEEAHD_01615 9.5e-94 3.5.2.6 V D-alanyl-D-alanine carboxypeptidase
APGEEAHD_01616 3.2e-92 dps P Belongs to the Dps family
APGEEAHD_01617 4.4e-115 pilD 3.4.23.43 NOU Bacterial Peptidase A24 N-terminal domain
APGEEAHD_01618 2e-186 3.5.2.6 V D-alanyl-D-alanine carboxypeptidase
APGEEAHD_01619 2.5e-112 sodA 1.15.1.1 C radicals which are normally produced within the cells and which are toxic to biological systems
APGEEAHD_01620 1.2e-183 holA 2.7.7.7 L DNA polymerase III delta subunit
APGEEAHD_01621 0.0 ppc 4.1.1.31 H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
APGEEAHD_01622 6.2e-56 S Domain of unknown function (DUF4430)
APGEEAHD_01623 1.8e-73 S Psort location CytoplasmicMembrane, score
APGEEAHD_01624 2.3e-130 htpX O Belongs to the peptidase M48B family
APGEEAHD_01625 1.7e-91 lemA S LemA family
APGEEAHD_01626 3.3e-170 spd F DNA RNA non-specific endonuclease
APGEEAHD_01627 5.1e-38
APGEEAHD_01628 9.4e-44
APGEEAHD_01629 1.4e-124 hsdS 3.1.21.3 V Type I restriction modification DNA specificity domain
APGEEAHD_01630 2.5e-289 hsdM 2.1.1.72 V N-6 DNA Methylase
APGEEAHD_01631 0.0 hsdR 3.1.21.3 V Type I restriction enzyme R protein N terminus (HSDR_N)
APGEEAHD_01632 1.2e-21 MA20_36090 S Protein of unknown function (DUF2974)
APGEEAHD_01633 7.2e-23 MA20_36090 S Protein of unknown function (DUF2974)
APGEEAHD_01634 2.3e-113 1.14.14.5 C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APGEEAHD_01635 2.7e-27 P Hemerythrin HHE cation binding domain protein
APGEEAHD_01636 2.8e-155 XK27_00880 3.5.1.28 M Glycosyl hydrolase, family 25
APGEEAHD_01637 7.9e-82 ybaK S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APGEEAHD_01638 3.6e-114 pgm6 5.4.2.11, 5.4.2.12 G phosphoglycerate mutase
APGEEAHD_01639 7.5e-174 S hydrolase
APGEEAHD_01640 7.6e-16
APGEEAHD_01641 1e-163 M LysM domain
APGEEAHD_01642 9.9e-288 lysS 6.1.1.6 J Belongs to the class-II aminoacyl-tRNA synthetase family
APGEEAHD_01643 0.0 L helicase
APGEEAHD_01644 1.2e-67 nudG 3.6.1.55, 3.6.1.65 L Belongs to the Nudix hydrolase family
APGEEAHD_01645 9.6e-12
APGEEAHD_01646 7.8e-236 mntH P H( )-stimulated, divalent metal cation uptake system
APGEEAHD_01647 1.1e-33 XK27_12190 S protein conserved in bacteria
APGEEAHD_01649 8.4e-88 bioY S biotin synthase
APGEEAHD_01650 8.1e-46 S CHY zinc finger
APGEEAHD_01651 3.4e-252 yegQ O Peptidase U32
APGEEAHD_01652 2e-177 yegQ O Peptidase U32
APGEEAHD_01654 5.5e-69 ytxH S General stress protein
APGEEAHD_01656 4e-147 lgt 2.1.1.199 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
APGEEAHD_01657 1e-170 hprK F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
APGEEAHD_01658 9.9e-42 pspC KT PspC domain
APGEEAHD_01659 0.0 yhgF K Transcriptional accessory protein
APGEEAHD_01661 1.2e-155 XK27_03015 S permease
APGEEAHD_01662 2.7e-146 ycgQ S TIGR03943 family
APGEEAHD_01663 1e-185 S CRISPR-associated protein Csn2 subfamily St
APGEEAHD_01664 3.1e-53 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
APGEEAHD_01665 1.1e-172 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
APGEEAHD_01666 0.0 cas9 L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
APGEEAHD_01667 3.3e-96
APGEEAHD_01668 5.6e-27 estA E GDSL-like Lipase/Acylhydrolase
APGEEAHD_01669 2.5e-42 S CAAX protease self-immunity
APGEEAHD_01670 1.7e-26 S CAAX protease self-immunity
APGEEAHD_01671 1.2e-32
APGEEAHD_01673 3.3e-64 yqeB S Pyrimidine dimer DNA glycosylase
APGEEAHD_01674 7.8e-59 S Protein of unknown function (DUF1722)
APGEEAHD_01675 8.9e-11
APGEEAHD_01676 2.3e-156 L COG2801 Transposase and inactivated derivatives
APGEEAHD_01677 1.5e-37 L transposase activity
APGEEAHD_01678 4.2e-142 purR 2.4.2.7 F operon repressor
APGEEAHD_01679 4e-178 cbf S 3'-5' exoribonuclease yhaM
APGEEAHD_01680 6.9e-173 rmuC S RmuC domain protein
APGEEAHD_01681 3.1e-118 thiN 2.7.6.2 H thiamine pyrophosphokinase
APGEEAHD_01682 3e-119 rpe 5.1.3.1 G Belongs to the ribulose-phosphate 3-epimerase family
APGEEAHD_01683 6.4e-162 rsgA 3.1.3.100 G One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
APGEEAHD_01685 4e-156 ksgA 2.1.1.182 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
APGEEAHD_01686 8.4e-99 rnmV 3.1.26.8 J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
APGEEAHD_01687 4.1e-144 tatD L Hydrolase, tatd
APGEEAHD_01688 2.5e-74 yccU S CoA-binding protein
APGEEAHD_01689 4.8e-51 trxA O Belongs to the thioredoxin family
APGEEAHD_01690 1.9e-141 S Macro domain protein
APGEEAHD_01691 2e-09 L thioesterase
APGEEAHD_01692 2.2e-54 bta 1.8.1.8 CO cell redox homeostasis
APGEEAHD_01694 3.7e-44 L Transposase
APGEEAHD_01695 3.7e-54 hsdS 2.1.1.72, 3.1.21.3 V type I restriction modification DNA specificity domain
APGEEAHD_01696 1.7e-111 hsdM 2.1.1.72 V type I restriction-modification system
APGEEAHD_01697 3.7e-157 glcU U Glucose uptake
APGEEAHD_01698 1.8e-08 4.2.1.53 S Myosin-crossreactive antigen
APGEEAHD_01699 5.9e-79 hsdM 2.1.1.72 V HsdM N-terminal domain
APGEEAHD_01700 2.2e-101 XK27_10720 D peptidase activity
APGEEAHD_01701 3.1e-292 adcA P Belongs to the bacterial solute-binding protein 9 family
APGEEAHD_01702 1.5e-194 3.1.21.3 L Subunit R is required for both nuclease and ATPase activities, but not for modification
APGEEAHD_01703 2.3e-170 mccA 2.5.1.134, 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
APGEEAHD_01704 2.7e-219 metC 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
APGEEAHD_01705 1.5e-95 cysE 2.3.1.30 E Bacterial transferase hexapeptide (six repeats)
APGEEAHD_01706 3.2e-141 ppiA 5.2.1.8 O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APGEEAHD_01707 9.7e-77 2.7.1.199, 2.7.1.211 G PTS glucose transporter subunit IIA
APGEEAHD_01708 9e-96 pts33BCA G pts system
APGEEAHD_01709 5.8e-71 pts33BCA G pts system
APGEEAHD_01710 1.5e-25 2.7.1.208, 2.7.1.211 G protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APGEEAHD_01711 1.1e-09 uvrX 2.7.7.7 L ImpB mucB samB family
APGEEAHD_01712 1.8e-254 cycA E permease
APGEEAHD_01713 4.5e-39 ynzC S UPF0291 protein
APGEEAHD_01714 0.0 glyS 6.1.1.14 J Glycyl-tRNA synthetase beta subunit
APGEEAHD_01715 4.8e-176 glyQ 6.1.1.14 J glycyl-tRNA synthetase alpha subunit
APGEEAHD_01716 6.1e-63 S membrane
APGEEAHD_01717 1.5e-59
APGEEAHD_01718 7.5e-26
APGEEAHD_01719 1.8e-53
APGEEAHD_01720 2.1e-221 nagA 3.5.1.25 G Belongs to the metallo-dependent hydrolases superfamily. NagA family
APGEEAHD_01721 2.9e-68 nptA P sodium-dependent phosphate transmembrane transporter activity
APGEEAHD_01722 5.8e-149 XK27_04800 S Sucrose-6F-phosphate phosphohydrolase
APGEEAHD_01723 4.9e-106 mur1 NU mannosyl-glycoprotein
APGEEAHD_01724 3.3e-53 glnB K Belongs to the P(II) protein family
APGEEAHD_01725 7.5e-233 amt P Ammonium Transporter
APGEEAHD_01726 3.9e-159 rsmI 2.1.1.198 H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
APGEEAHD_01727 9.5e-55 yabA L Involved in initiation control of chromosome replication
APGEEAHD_01728 3.1e-134 yaaT S stage 0 sporulation protein
APGEEAHD_01729 5.4e-161 holB 2.7.7.7 L dna polymerase iii
APGEEAHD_01730 2.8e-111 tmk 2.7.4.9 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APGEEAHD_01731 1.4e-136 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
APGEEAHD_01732 9.5e-225 tuf J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APGEEAHD_01733 2.8e-230 ftsW D Belongs to the SEDS family
APGEEAHD_01734 5.2e-67 atpC C Produces ATP from ADP in the presence of a proton gradient across the membrane
APGEEAHD_01735 2.7e-263 atpD 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
APGEEAHD_01736 2.5e-158 atpG C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
APGEEAHD_01737 3.8e-279 atpA 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
APGEEAHD_01738 3.5e-86 atpH C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APGEEAHD_01739 3.3e-78 atpF C ATP synthase F(0) sector subunit b
APGEEAHD_01740 3.1e-122 atpB C it plays a direct role in the translocation of protons across the membrane
APGEEAHD_01741 3.2e-16 atpE C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APGEEAHD_01742 0.0 valS 6.1.1.9 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
APGEEAHD_01743 1.9e-46 2.3.1.128, 5.2.1.8 J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APGEEAHD_01744 2.6e-91 S COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APGEEAHD_01745 8.9e-14 coiA 3.6.4.12 S Competence protein
APGEEAHD_01746 2.2e-15 T peptidase
APGEEAHD_01747 5.5e-153 rarD S Transporter
APGEEAHD_01748 1.1e-153 thrB 2.7.1.39 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
APGEEAHD_01749 1.8e-237 hom 1.1.1.3, 2.7.2.4 E homoserine dehydrogenase
APGEEAHD_01750 2e-131 yxkH G deacetylase
APGEEAHD_01751 1.6e-210 argD 2.6.1.11, 2.6.1.17 E acetylornithine aminotransferase
APGEEAHD_01752 5.5e-130 argB 2.7.2.8 E Belongs to the acetylglutamate kinase family. ArgB subfamily
APGEEAHD_01753 1.5e-222 argJ 2.3.1.1, 2.3.1.35, 2.7.2.8 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
APGEEAHD_01754 1.5e-191 argC 1.2.1.38 E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APGEEAHD_01755 1.2e-227 mtnE 2.6.1.83 E mutations do not affect methionine salvage in vivo however
APGEEAHD_01756 1.2e-146 cnhA 3.5.1.3 S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
APGEEAHD_01757 7.9e-104 3.4.17.14, 3.5.1.28 NU amidase activity
APGEEAHD_01758 1.3e-147 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
APGEEAHD_01759 7.9e-24 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
APGEEAHD_01760 0.0 alaS 6.1.1.7 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APGEEAHD_01761 1.5e-166 prsA 3.1.3.16, 5.2.1.8 O peptidyl-prolyl cis-trans isomerase activity
APGEEAHD_01762 5.4e-127 yrrM 2.1.1.104 S O-Methyltransferase
APGEEAHD_01763 0.0 pepF E oligoendopeptidase F
APGEEAHD_01764 1.4e-186 coiA 3.6.4.12 S Competence protein
APGEEAHD_01765 1.8e-164 K transcriptional regulator (lysR family)
APGEEAHD_01766 0.0 metG 6.1.1.10, 6.1.1.20 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APGEEAHD_01770 8e-191 phoH T phosphate starvation-inducible protein PhoH
APGEEAHD_01771 2.7e-65 rlpA M LysM domain protein
APGEEAHD_01772 6.7e-124 usp 3.5.1.104, 3.5.1.28 CBM50 S pathogenesis
APGEEAHD_01773 7.4e-35 yozE S Belongs to the UPF0346 family
APGEEAHD_01774 5.3e-161 cvfB S Protein conserved in bacteria
APGEEAHD_01775 1.3e-91 frr J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
APGEEAHD_01776 4.9e-131 pyrH 2.7.4.22 F Catalyzes the reversible phosphorylation of UMP to UDP
APGEEAHD_01777 3.2e-78 sptS 2.7.13.3 T Histidine kinase
APGEEAHD_01778 2.2e-18 K Acetyltransferase (GNAT) family
APGEEAHD_01779 0.0 lmrA2 V abc transporter atp-binding protein
APGEEAHD_01780 2.5e-311 lmrA1 V abc transporter atp-binding protein
APGEEAHD_01781 1.9e-77 K DNA-binding transcription factor activity
APGEEAHD_01782 1e-69 def_1 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins
APGEEAHD_01783 1.8e-256 gdhA 1.4.1.4 E Belongs to the Glu Leu Phe Val dehydrogenases family
APGEEAHD_01784 1.3e-58 nadD 2.7.1.22, 2.7.7.1, 2.7.7.18, 3.6.1.55 H adenylyltransferase
APGEEAHD_01785 1.6e-137 nadD 2.7.1.22, 2.7.7.1, 2.7.7.18, 3.6.1.55 H adenylyltransferase
APGEEAHD_01786 2.1e-137 3.6.1.13, 3.6.1.55 F AdP-ribose pyrophosphatase
APGEEAHD_01787 1.6e-24 U response to pH
APGEEAHD_01788 0.0 yfmR S abc transporter atp-binding protein
APGEEAHD_01789 1.9e-225 cca 2.7.7.19, 2.7.7.72 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
APGEEAHD_01790 1.1e-138 dapB 1.17.1.8 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
APGEEAHD_01791 5.5e-75 XK27_08360 S EDD domain protein, DegV family
APGEEAHD_01792 6.4e-61 XK27_08360 S EDD domain protein, DegV family
APGEEAHD_01793 2.6e-64 WQ51_03320 S cog cog4835
APGEEAHD_01794 3e-130 ydaF_2 J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APGEEAHD_01795 1.5e-46 rpmA J Belongs to the bacterial ribosomal protein bL27 family
APGEEAHD_01796 4.5e-49 rplU J This protein binds to 23S rRNA in the presence of protein L20
APGEEAHD_01797 6.4e-29 2.3.1.128 K acetyltransferase
APGEEAHD_01798 7.2e-258 gtf2 M A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1
APGEEAHD_01799 8.4e-295 gtf1 2.4.1.52 GT4 M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
APGEEAHD_01800 1.5e-228 thiI 2.8.1.4 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APGEEAHD_01801 6.1e-213 iscS2 2.8.1.7 E Cysteine sulfinate desulfinase cysteine desulfurase and related enzymes
APGEEAHD_01803 6.2e-243 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
APGEEAHD_01804 2.7e-260 gor 1.8.1.7 C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APGEEAHD_01805 4e-238 fruA 2.7.1.202 G phosphotransferase system
APGEEAHD_01806 2.1e-78 fruA 2.7.1.202 GT PTS system, Lactose/Cellobiose specific IIB subunit
APGEEAHD_01807 4.6e-163 pfkB 2.7.1.11, 2.7.1.56 H Belongs to the carbohydrate kinase PfkB family. LacC subfamily
APGEEAHD_01808 2.1e-113 fruR K transcriptional
APGEEAHD_01809 1.8e-84 L Transposase
APGEEAHD_01810 1.5e-204 rny D Endoribonuclease that initiates mRNA decay
APGEEAHD_01811 4.7e-90 luxS 4.4.1.21 H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
APGEEAHD_01812 6.7e-139 accA 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
APGEEAHD_01813 4.6e-160 accD 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
APGEEAHD_01814 7.5e-258 accC 6.3.4.14, 6.4.1.2 I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
APGEEAHD_01815 1.5e-71 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
APGEEAHD_01816 1.1e-54 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
APGEEAHD_01817 2.6e-233 fabF 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
APGEEAHD_01818 1.3e-126 IQ reductase
APGEEAHD_01819 1.9e-164 fabD 2.3.1.39 I Malonyl CoA-acyl carrier protein transacylase
APGEEAHD_01820 5.8e-172 fabK 1.3.1.9 S 2-Nitropropane dioxygenase
APGEEAHD_01821 3.3e-30 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
APGEEAHD_01822 2.3e-173 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APGEEAHD_01823 4e-72 marR K Transcriptional regulator, MarR family
APGEEAHD_01824 2.4e-139 phaB 5.3.3.14, 5.3.3.18 I Belongs to the enoyl-CoA hydratase isomerase family
APGEEAHD_01825 1.9e-115 S Haloacid dehalogenase-like hydrolase
APGEEAHD_01826 2.4e-256 lysC 2.7.2.4 E Belongs to the aspartokinase family
APGEEAHD_01827 8e-193 asnA 6.3.1.1 E aspartate--ammonia ligase
APGEEAHD_01828 6.7e-259 rumA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APGEEAHD_01829 1.2e-130 recX 2.4.1.337 GT4 S Regulatory protein RecX
APGEEAHD_01830 7.8e-102 ygaC J Belongs to the UPF0374 family
APGEEAHD_01831 6.4e-108 S Domain of unknown function (DUF1803)
APGEEAHD_01832 2.1e-166 ppaC 3.6.1.1 C inorganic pyrophosphatase
APGEEAHD_01839 3.9e-122 L Transposase
APGEEAHD_01840 2.3e-66 spxA_2 1.20.4.1 P Belongs to the ArsC family
APGEEAHD_01841 4.7e-205 recA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
APGEEAHD_01842 1e-232 cinA 3.5.1.42 S Belongs to the CinA family
APGEEAHD_01843 1.9e-106 tag 3.2.2.20 L 3-methyladenine DNA glycosylase
APGEEAHD_01844 7.8e-103 ruvA 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
APGEEAHD_01846 0.0 mutL L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
APGEEAHD_01848 1.2e-61 KT phosphorelay signal transduction system
APGEEAHD_01849 7e-34 S Protein of unknown function (DUF3021)
APGEEAHD_01850 0.0 mutS L that it carries out the mismatch recognition step. This protein has a weak ATPase activity
APGEEAHD_01851 1e-57 ymcA 3.6.3.21 S Belongs to the UPF0342 family
APGEEAHD_01852 8.2e-70 argR K Regulates arginine biosynthesis genes
APGEEAHD_01854 1.1e-56 T Toxic component of a toxin-antitoxin (TA) module
APGEEAHD_01858 7.8e-146 dinB 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APGEEAHD_01859 4.1e-35 dinB 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APGEEAHD_01860 0.0 pflB 2.3.1.54 C formate acetyltransferase'
APGEEAHD_01861 1.8e-147 cah 4.2.1.1 P carbonic anhydrase
APGEEAHD_01862 2.1e-85 yjcF S COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
APGEEAHD_01863 1e-44 hsdS_1 3.1.21.3 V type I restriction modification DNA specificity domain
APGEEAHD_01864 2.9e-87 D nuclear chromosome segregation
APGEEAHD_01865 1.5e-127 ybbM S transport system, permease component
APGEEAHD_01866 1.2e-117 ybbL S abc transporter atp-binding protein
APGEEAHD_01867 4.5e-185 ampC V COG1680 Beta-lactamase class C and other penicillin binding proteins
APGEEAHD_01868 4.6e-140 cppA E CppA N-terminal
APGEEAHD_01869 5e-44 V CAAX protease self-immunity
APGEEAHD_01870 2.3e-164 gla U Belongs to the MIP aquaporin (TC 1.A.8) family
APGEEAHD_01871 0.0 pepX 3.4.14.11 E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline
APGEEAHD_01874 3e-47 spiA K sequence-specific DNA binding
APGEEAHD_01875 2.9e-28 blpT
APGEEAHD_01876 6.7e-98 blpT
APGEEAHD_01877 4.2e-35 amiA E ABC transporter, substrate-binding protein, family 5
APGEEAHD_01878 1.2e-09 L Transposase
APGEEAHD_01879 0.0 argS 6.1.1.19 J Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
APGEEAHD_01880 1.6e-246 purB 4.3.2.2 F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APGEEAHD_01881 4.3e-33
APGEEAHD_01882 5.6e-86 1.1.1.169 H Ketopantoate reductase
APGEEAHD_01883 3.2e-46 1.1.1.169 H Ketopantoate reductase
APGEEAHD_01884 8.5e-204 purK 6.3.4.18 F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
APGEEAHD_01885 4.9e-76 purE 5.4.99.18 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
APGEEAHD_01886 3.4e-241 purD 6.3.4.13 F Belongs to the GARS family
APGEEAHD_01887 2.3e-161 S CHAP domain
APGEEAHD_01888 2e-32 L Integrase core domain protein
APGEEAHD_01889 3.5e-50 L transposition
APGEEAHD_01890 1e-90 L transposase activity
APGEEAHD_01891 6.6e-295 purH 2.1.2.3, 3.5.4.10 F Bifunctional purine biosynthesis protein PurH
APGEEAHD_01892 1.4e-101 purN 2.1.2.2 F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
APGEEAHD_01893 4.8e-185 purM 6.3.3.1, 6.3.4.13 F Phosphoribosylformylglycinamidine cyclo-ligase
APGEEAHD_01894 1.3e-276 purF 2.4.2.14 F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
APGEEAHD_01895 0.0 purL 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APGEEAHD_01896 9.9e-129 purC 4.1.1.21, 4.3.2.2, 6.3.2.6 F Belongs to the SAICAR synthetase family
APGEEAHD_01897 9.3e-34 acpP1 IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
APGEEAHD_01898 9.6e-178 plsX 2.3.1.15 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
APGEEAHD_01899 7e-144 recO L Involved in DNA repair and RecF pathway recombination
APGEEAHD_01900 2.9e-218 araT 2.6.1.1 E Aminotransferase
APGEEAHD_01901 1.2e-174 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APGEEAHD_01902 5.5e-94 usp 3.5.1.28 CBM50 S CHAP domain
APGEEAHD_01903 6.3e-88 mreD M Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
APGEEAHD_01904 5.5e-139 mreC M Involved in formation and maintenance of cell shape
APGEEAHD_01910 5.3e-11

eggNOG-mapper v2 (Database: eggNOG v5.0, Jul. 2018 release)