ORF_ID e_value Gene_name EC_number CAZy COGs Description
APPPKGNO_00001 6.9e-30 yqkB S Belongs to the HesB IscA family
APPPKGNO_00002 2.3e-65 yxkH G Polysaccharide deacetylase
APPPKGNO_00003 9.6e-09
APPPKGNO_00004 2.9e-53 K LysR substrate binding domain
APPPKGNO_00005 2e-122 MA20_14895 S Conserved hypothetical protein 698
APPPKGNO_00006 1.1e-199 nupG F Nucleoside
APPPKGNO_00007 1.8e-105 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
APPPKGNO_00008 2.2e-49 rnpA 3.1.26.5 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
APPPKGNO_00009 3.4e-14 rpmH J Belongs to the bacterial ribosomal protein bL34 family
APPPKGNO_00010 2.1e-204 dnaA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APPPKGNO_00011 3.9e-159 dnaN 2.7.7.7 L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
APPPKGNO_00012 9e-20 yaaA S S4 domain protein YaaA
APPPKGNO_00013 9.3e-153 recF L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APPPKGNO_00014 0.0 gyrB 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APPPKGNO_00015 0.0 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APPPKGNO_00016 4.8e-45 rpsF J Binds together with S18 to 16S ribosomal RNA
APPPKGNO_00017 3.3e-63 ssb L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
APPPKGNO_00018 6.2e-35 rpsR J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
APPPKGNO_00019 2.5e-110 glxR 1.1.1.31, 1.1.1.60 I Dehydrogenase
APPPKGNO_00020 7.3e-117 S Glycosyl transferase family 2
APPPKGNO_00021 7.4e-64 D peptidase
APPPKGNO_00022 0.0 asnB 6.3.5.4 E Asparagine synthase
APPPKGNO_00023 1.9e-47 yiiE S Protein of unknown function (DUF1211)
APPPKGNO_00024 7.8e-40 mscL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
APPPKGNO_00025 6.3e-247 poxB 1.2.3.3, 1.2.5.1 EH Belongs to the TPP enzyme family
APPPKGNO_00026 3.6e-17 yneR
APPPKGNO_00027 8.7e-231 murE 6.3.2.13, 6.3.2.7 M Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APPPKGNO_00028 4.9e-224 yxbA 6.3.1.12 S ATP-grasp enzyme
APPPKGNO_00029 2.4e-106 racD 5.1.1.13 M Belongs to the aspartate glutamate racemases family
APPPKGNO_00030 9.9e-153 mdtG EGP Major facilitator Superfamily
APPPKGNO_00031 1e-14 yobS K transcriptional regulator
APPPKGNO_00032 2.8e-109 glcU U sugar transport
APPPKGNO_00033 3.4e-170 yjjP S Putative threonine/serine exporter
APPPKGNO_00034 1.4e-69 2.3.1.178 J Acetyltransferase (GNAT) domain
APPPKGNO_00035 3.7e-96 yicL EG EamA-like transporter family
APPPKGNO_00036 6e-223 pepF E Oligopeptidase F
APPPKGNO_00037 1.5e-108 mccA 2.5.1.134, 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
APPPKGNO_00038 4.9e-178 metC 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
APPPKGNO_00039 6.6e-140 gldA 1.1.1.6 C Iron-containing alcohol dehydrogenase
APPPKGNO_00040 4.1e-61 msrB 1.8.4.11, 1.8.4.12 O peptide methionine sulfoxide reductase
APPPKGNO_00041 4e-23 relB L RelB antitoxin
APPPKGNO_00043 2.9e-172 S Putative peptidoglycan binding domain
APPPKGNO_00044 1.2e-31 K Transcriptional regulator, MarR family
APPPKGNO_00045 1.4e-216 XK27_09600 V ABC transporter, ATP-binding protein
APPPKGNO_00046 1.1e-229 V ABC transporter transmembrane region
APPPKGNO_00048 9.1e-93 S Domain of unknown function DUF87
APPPKGNO_00050 7.9e-106 yxeH S hydrolase
APPPKGNO_00051 9e-114 K response regulator
APPPKGNO_00052 1.1e-272 vicK 2.7.13.3 T Histidine kinase
APPPKGNO_00053 4.6e-103 yycH S YycH protein
APPPKGNO_00054 5.6e-80 yycI S YycH protein
APPPKGNO_00055 3.1e-30 yyaQ S YjbR
APPPKGNO_00056 3.7e-145 htrA 3.4.21.107 O serine protease
APPPKGNO_00057 1.5e-72 rlmH 2.1.1.177 J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
APPPKGNO_00058 4.4e-40 1.6.5.2 GM NAD(P)H-binding
APPPKGNO_00059 3.3e-25 K MarR family transcriptional regulator
APPPKGNO_00060 5.9e-88 GM Belongs to the short-chain dehydrogenases reductases (SDR) family
APPPKGNO_00061 2e-46 3.6.4.12 S PD-(D/E)XK nuclease family transposase
APPPKGNO_00063 9.4e-208 G glycerol-3-phosphate transporter
APPPKGNO_00064 1.6e-102 ftsW D Belongs to the SEDS family
APPPKGNO_00065 0.0 pyc 6.4.1.1 C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
APPPKGNO_00066 1.1e-17 ylbG S Uncharacterized protein conserved in bacteria (DUF2129)
APPPKGNO_00067 7.2e-74 rsmD 2.1.1.171 L RNA methyltransferase, RsmD family
APPPKGNO_00068 4e-49 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
APPPKGNO_00069 2.4e-131 ylbL T Belongs to the peptidase S16 family
APPPKGNO_00070 2.2e-96 purC 4.1.1.21, 4.3.2.2, 6.3.2.6 F Belongs to the SAICAR synthetase family
APPPKGNO_00071 2.2e-30 purS 6.3.2.6, 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APPPKGNO_00072 6.8e-103 purQ 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APPPKGNO_00073 0.0 purL 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APPPKGNO_00074 2.1e-226 purF 2.4.2.14 F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
APPPKGNO_00075 2.4e-139 purM 6.3.3.1, 6.3.4.13 F Phosphoribosylformylglycinamidine cyclo-ligase
APPPKGNO_00076 5.2e-75 purN 2.1.2.2 F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
APPPKGNO_00077 8.5e-234 purH 2.1.2.3, 3.5.4.10 F Bifunctional purine biosynthesis protein PurH
APPPKGNO_00078 1e-152 purD 6.3.4.13 F Belongs to the GARS family
APPPKGNO_00079 1.5e-93 S Acyltransferase family
APPPKGNO_00080 2.2e-194 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APPPKGNO_00081 3.9e-122 K LysR substrate binding domain
APPPKGNO_00083 2.2e-20
APPPKGNO_00084 6.2e-59 yjjG 3.1.3.102, 3.1.3.104, 3.1.3.5, 3.8.1.2 S Haloacid dehalogenase-like hydrolase
APPPKGNO_00085 2.2e-267 argS 6.1.1.19 J Arginyl-tRNA synthetase
APPPKGNO_00086 1.4e-50 comEA L Competence protein ComEA
APPPKGNO_00087 2e-69 comEB 3.5.4.12 F ComE operon protein 2
APPPKGNO_00088 3.3e-154 comEC S Competence protein ComEC
APPPKGNO_00089 9.3e-104 holA 2.7.7.7 L DNA polymerase III delta subunit
APPPKGNO_00090 1.3e-113 fni 1.1.1.88, 5.3.3.2 C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
APPPKGNO_00091 3e-137 mvaK2 2.7.1.36, 2.7.1.43, 2.7.4.2 I phosphomevalonate kinase
APPPKGNO_00092 2.8e-118 mvaD 4.1.1.33 I diphosphomevalonate decarboxylase
APPPKGNO_00093 1.8e-93 mvk 1.1.1.88, 2.3.3.10, 2.7.1.36 I mevalonate kinase
APPPKGNO_00094 3.9e-229 dinG 2.7.7.7, 3.6.4.12 L helicase involved in DNA repair and perhaps also replication
APPPKGNO_00095 1.8e-36 ypmB S Protein conserved in bacteria
APPPKGNO_00096 1.2e-142 aspB 2.6.1.1, 2.6.1.14 E Aminotransferase
APPPKGNO_00097 7.6e-236 asnS 6.1.1.22 J Asparaginyl-tRNA synthetase
APPPKGNO_00098 5.1e-56 dnaD L DnaD domain protein
APPPKGNO_00099 4.4e-83 nth 4.2.99.18 L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APPPKGNO_00100 5.8e-78 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APPPKGNO_00101 9.6e-126 yitT S Uncharacterised 5xTM membrane BCR, YitT family COG1284
APPPKGNO_00102 1.9e-93 M transferase activity, transferring glycosyl groups
APPPKGNO_00103 1.4e-83 M Glycosyltransferase sugar-binding region containing DXD motif
APPPKGNO_00104 5.8e-100 epsJ1 M Glycosyltransferase like family 2
APPPKGNO_00107 1.1e-115 yqfL 2.7.11.33, 2.7.4.28 F Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation
APPPKGNO_00108 4.7e-22 rpsU J Belongs to the bacterial ribosomal protein bS21 family
APPPKGNO_00109 1.8e-56 yqeY S YqeY-like protein
APPPKGNO_00111 3.9e-68 xerD L Phage integrase, N-terminal SAM-like domain
APPPKGNO_00112 1e-106 ypjC S Uncharacterised 5xTM membrane BCR, YitT family COG1284
APPPKGNO_00113 1.1e-107 dapB 1.17.1.8 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
APPPKGNO_00114 6.6e-133 cca 2.7.7.19, 2.7.7.72 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
APPPKGNO_00115 2.9e-276 yfmR S ABC transporter, ATP-binding protein
APPPKGNO_00116 4.4e-156 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
APPPKGNO_00117 3.2e-57 folA 1.5.1.3 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
APPPKGNO_00118 8.6e-135 yvgN C Aldo keto reductase
APPPKGNO_00119 2.4e-35 K helix_turn_helix, mercury resistance
APPPKGNO_00120 1.3e-102 S Aldo keto reductase
APPPKGNO_00122 6.5e-80 ypmR E GDSL-like Lipase/Acylhydrolase
APPPKGNO_00123 2.2e-52 ypmS S Uncharacterized protein conserved in bacteria (DUF2140)
APPPKGNO_00124 3.6e-24 yozE S Belongs to the UPF0346 family
APPPKGNO_00125 4.7e-133 ylqF S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
APPPKGNO_00126 4.9e-97 rnhB 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APPPKGNO_00127 6.2e-85 dprA LU DNA protecting protein DprA
APPPKGNO_00128 0.0 topA 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
APPPKGNO_00129 9.5e-210 trmFO 2.1.1.74 J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
APPPKGNO_00130 5.8e-205 G PTS system Galactitol-specific IIC component
APPPKGNO_00131 2.3e-81 K Bacterial regulatory proteins, tetR family
APPPKGNO_00132 1.6e-128 yjjC V ATPases associated with a variety of cellular activities
APPPKGNO_00133 2.1e-203 M Exporter of polyketide antibiotics
APPPKGNO_00134 1.8e-100 pgm6 5.4.2.11, 5.4.2.12 G Phosphoglycerate mutase family
APPPKGNO_00135 2.7e-35 S Repeat protein
APPPKGNO_00136 2e-277 recD2 3.1.11.5 L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
APPPKGNO_00137 3.4e-91 L Belongs to the 'phage' integrase family
APPPKGNO_00138 4.3e-14 L Belongs to the 'phage' integrase family
APPPKGNO_00140 1.4e-22 dinG 2.7.7.7, 3.6.4.12 L DNA-directed DNA polymerase activity
APPPKGNO_00141 1.9e-13
APPPKGNO_00142 1.7e-17 L nuclease
APPPKGNO_00143 9.6e-28 S Short C-terminal domain
APPPKGNO_00145 8.4e-38 E Zn peptidase
APPPKGNO_00146 2.4e-37 K Helix-turn-helix XRE-family like proteins
APPPKGNO_00147 3.5e-10 XK27_07105 K Helix-turn-helix XRE-family like proteins
APPPKGNO_00150 3.8e-86 spoU 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APPPKGNO_00151 2.1e-67 XK27_09705 6.1.1.14 S Metal dependent phosphohydrolases with conserved 'HD' motif.
APPPKGNO_00152 9.1e-43 yodB K Transcriptional regulator, HxlR family
APPPKGNO_00153 7.4e-173 pheS 6.1.1.20 J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
APPPKGNO_00154 0.0 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
APPPKGNO_00155 1.5e-126 mltG S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
APPPKGNO_00156 1.8e-97 udk 2.7.1.48 F Cytidine monophosphokinase
APPPKGNO_00157 2.2e-68 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
APPPKGNO_00158 6.4e-12
APPPKGNO_00159 1.5e-143 iunH2 3.2.2.1 F nucleoside hydrolase
APPPKGNO_00160 1.3e-42 XK27_03960 S Protein of unknown function (DUF3013)
APPPKGNO_00161 1.9e-116 prmA J Ribosomal protein L11 methyltransferase
APPPKGNO_00162 1.8e-77 rsmE 2.1.1.193 J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
APPPKGNO_00163 0.0 relA 2.7.6.5 KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APPPKGNO_00164 1.7e-54 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
APPPKGNO_00165 2.5e-56 3.1.3.18 J HAD-hyrolase-like
APPPKGNO_00166 5.2e-43 lspA 3.4.23.36 MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APPPKGNO_00167 5.6e-129 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
APPPKGNO_00168 1.3e-75 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
APPPKGNO_00169 2.7e-204 pyrP F Permease
APPPKGNO_00170 2.8e-114 carA 6.3.5.5 F Carbamoyl-phosphate synthetase glutamine chain
APPPKGNO_00171 2.2e-191 carB 6.3.5.5 F Carbamoyl-phosphate synthase
APPPKGNO_00172 2e-84 pyrF 4.1.1.23 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
APPPKGNO_00173 2.3e-89 pyrE 2.4.2.10, 4.1.1.23 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APPPKGNO_00174 8.3e-134 K Transcriptional regulator
APPPKGNO_00175 1.1e-143 ppaC 3.6.1.1 C inorganic pyrophosphatase
APPPKGNO_00176 8.6e-115 glcR K DeoR C terminal sensor domain
APPPKGNO_00177 4.5e-171 patA 2.6.1.1 E Aminotransferase
APPPKGNO_00178 2.4e-88 murI 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
APPPKGNO_00180 1.1e-35 gpsB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
APPPKGNO_00181 6.1e-173 rlmL 2.1.1.173, 2.1.1.264 L Belongs to the methyltransferase superfamily
APPPKGNO_00182 1.8e-36 rnhA 3.1.26.4 L Ribonuclease HI
APPPKGNO_00183 6.2e-21 S Family of unknown function (DUF5322)
APPPKGNO_00184 3.8e-256 fhs 6.3.4.3 F Belongs to the formate--tetrahydrofolate ligase family
APPPKGNO_00185 8e-39
APPPKGNO_00189 2.8e-16 V PFAM secretion protein HlyD family protein
APPPKGNO_00191 8.7e-150 EGP Sugar (and other) transporter
APPPKGNO_00192 6e-78 trmK 2.1.1.217 S SAM-dependent methyltransferase
APPPKGNO_00193 5.7e-104 yqfO 3.5.4.16 S Belongs to the GTP cyclohydrolase I type 2 NIF3 family
APPPKGNO_00194 6.5e-184 pepT 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
APPPKGNO_00195 4.2e-73 alkD L DNA alkylation repair enzyme
APPPKGNO_00196 3.8e-136 EG EamA-like transporter family
APPPKGNO_00197 3.6e-150 S Tetratricopeptide repeat protein
APPPKGNO_00198 2.4e-205 hisS 6.1.1.21 J histidyl-tRNA synthetase
APPPKGNO_00199 8.7e-299 aspS 6.1.1.12 J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
APPPKGNO_00200 7e-127 corA P CorA-like Mg2+ transporter protein
APPPKGNO_00201 8.5e-161 nhaC C Na H antiporter NhaC
APPPKGNO_00202 1.5e-130 dapF 5.1.1.7 E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
APPPKGNO_00203 2.2e-80 nudF 3.6.1.13 L ADP-ribose pyrophosphatase
APPPKGNO_00205 4.2e-92 mtnN 3.2.2.9 E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
APPPKGNO_00206 5.8e-155 iscS 2.8.1.7 E Aminotransferase class V
APPPKGNO_00207 3.7e-41 XK27_04120 S Putative amino acid metabolism
APPPKGNO_00208 3.7e-202 mnmA 2.8.1.13 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
APPPKGNO_00209 0.0 clpB O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
APPPKGNO_00210 4.3e-15 S Protein of unknown function (DUF2929)
APPPKGNO_00211 0.0 dnaE 2.7.7.7 L DNA polymerase
APPPKGNO_00212 1.9e-167 pfkA 2.7.1.11 F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
APPPKGNO_00213 6.3e-310 pyk 2.7.1.40, 2.7.7.4 G Belongs to the pyruvate kinase family
APPPKGNO_00215 2.2e-39 ypaA S Protein of unknown function (DUF1304)
APPPKGNO_00216 3.2e-83 plsY 2.3.1.15, 3.5.1.104 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
APPPKGNO_00217 0.0 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
APPPKGNO_00218 0.0 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
APPPKGNO_00219 1.6e-201 FbpA K Fibronectin-binding protein
APPPKGNO_00220 3.1e-40 K Transcriptional regulator
APPPKGNO_00221 6.3e-117 degV S EDD domain protein, DegV family
APPPKGNO_00222 3e-70 lepB 3.4.21.89 U Signal peptidase, peptidase S26
APPPKGNO_00223 2.4e-40 6.3.3.2 S ASCH
APPPKGNO_00224 1.8e-175 glyA 2.1.2.1 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
APPPKGNO_00225 5.3e-81 yjjH S Calcineurin-like phosphoesterase
APPPKGNO_00226 1.8e-95 EG EamA-like transporter family
APPPKGNO_00227 2.5e-84 natB CP ABC-type Na efflux pump, permease component
APPPKGNO_00228 4e-111 natA S Domain of unknown function (DUF4162)
APPPKGNO_00229 6.2e-23 K Acetyltransferase (GNAT) domain
APPPKGNO_00231 8.5e-36 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
APPPKGNO_00232 2.2e-227 der 1.1.1.399, 1.1.1.95 S GTPase that plays an essential role in the late steps of ribosome biogenesis
APPPKGNO_00233 2.7e-171 rpsA 1.17.7.4 J Ribosomal protein S1
APPPKGNO_00234 1.3e-59 arsC 1.20.4.1 T Low molecular weight phosphatase family
APPPKGNO_00235 1.2e-11 dltD M Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
APPPKGNO_00236 4.9e-29 dltC 6.1.1.13 J Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
APPPKGNO_00237 1.4e-175 dltB M MBOAT, membrane-bound O-acyltransferase family
APPPKGNO_00238 1.2e-219 dltA 6.1.1.13 H Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
APPPKGNO_00239 2.6e-07 dltX S D-Ala-teichoic acid biosynthesis protein
APPPKGNO_00240 2e-90 recO L Involved in DNA repair and RecF pathway recombination
APPPKGNO_00241 4.6e-155 era S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
APPPKGNO_00242 2.8e-30 dgkA 2.7.1.107, 2.7.1.66 M Diacylglycerol kinase
APPPKGNO_00243 3e-60 ybeY 2.6.99.2, 3.5.4.5 S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
APPPKGNO_00244 1.2e-153 phoH T phosphate starvation-inducible protein PhoH
APPPKGNO_00245 2.6e-83 lytH 3.5.1.28 M Ami_3
APPPKGNO_00246 2.6e-86 cmk 1.17.7.4, 2.5.1.19, 2.7.1.26, 2.7.4.25, 2.7.7.2, 6.3.2.1 F Belongs to the cytidylate kinase family. Type 1 subfamily
APPPKGNO_00247 7.7e-12 M Lysin motif
APPPKGNO_00248 2.2e-127 recQ 3.6.4.12 L ATP-dependent DNA helicase RecQ
APPPKGNO_00249 1.4e-59 ypbB 5.1.3.1 S Helix-turn-helix domain
APPPKGNO_00250 1.4e-220 mntH P H( )-stimulated, divalent metal cation uptake system
APPPKGNO_00251 1.3e-44 queD 4.1.2.50, 4.2.3.12 H 6-pyruvoyl tetrahydropterin synthase
APPPKGNO_00252 3.2e-120 ica2 GT2 M Glycosyl transferase family group 2
APPPKGNO_00253 1.4e-43
APPPKGNO_00254 7.2e-92 M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
APPPKGNO_00256 2.8e-186 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
APPPKGNO_00257 3.4e-213 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
APPPKGNO_00258 2.8e-280 glyS 6.1.1.14 J Glycyl-tRNA synthetase beta subunit
APPPKGNO_00259 3.7e-168 glyQ 6.1.1.14 J glycyl-tRNA synthetase alpha subunit
APPPKGNO_00260 3.7e-109 pepE 3.4.13.21 E Alpha/beta hydrolase of unknown function (DUF915)
APPPKGNO_00261 3.1e-75 pts13C G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
APPPKGNO_00262 9.5e-102 hsdS 3.1.21.3 V Type I restriction modification DNA specificity domain
APPPKGNO_00263 3.1e-77 hsdS_1 3.1.21.3 V K01154 type I restriction enzyme, S subunit
APPPKGNO_00264 4.7e-131 L Belongs to the 'phage' integrase family
APPPKGNO_00265 5.2e-69 3.1.21.3 V Type I restriction modification DNA specificity domain
APPPKGNO_00266 4e-202 hsdM 2.1.1.72 V type I restriction-modification system
APPPKGNO_00267 0.0 hsdR 3.1.21.3 V Subunit R is required for both nuclease and ATPase activities, but not for modification
APPPKGNO_00269 5.2e-81 XK27_07525 3.6.1.55 F Hydrolase, nudix family
APPPKGNO_00270 5.7e-57 3.6.1.27 I Acid phosphatase homologues
APPPKGNO_00271 1.8e-68 maa 2.3.1.79 S Maltose acetyltransferase
APPPKGNO_00272 4.8e-73 2.3.1.178 M GNAT acetyltransferase
APPPKGNO_00274 1.4e-197 ade 3.5.4.2 F Adenine deaminase C-terminal domain
APPPKGNO_00275 3.5e-65 ypsA S Belongs to the UPF0398 family
APPPKGNO_00276 6.4e-09 nhaC C Na H antiporter NhaC
APPPKGNO_00277 2.9e-168 nhaC C Na H antiporter NhaC
APPPKGNO_00278 1.8e-76 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
APPPKGNO_00279 1.1e-293 ponA 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein 1A
APPPKGNO_00280 4.3e-113 xerD D recombinase XerD
APPPKGNO_00281 2.4e-124 cvfB S S1 domain
APPPKGNO_00282 4.1e-51 yeaL S Protein of unknown function (DUF441)
APPPKGNO_00283 4.5e-58 U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
APPPKGNO_00284 5.8e-100 rluB 5.4.99.19, 5.4.99.21, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
APPPKGNO_00285 1.1e-56 scpB D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
APPPKGNO_00286 7e-59 scpA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
APPPKGNO_00287 4.6e-37 ribT K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
APPPKGNO_00288 7.8e-218 hslU O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
APPPKGNO_00289 7e-79 hslV 3.4.25.2 O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
APPPKGNO_00290 6e-123 xerC D Belongs to the 'phage' integrase family. XerC subfamily
APPPKGNO_00291 4.5e-179 cfa 2.1.1.317, 2.1.1.79 M cyclopropane-fatty-acyl-phospholipid synthase
APPPKGNO_00292 1.3e-99 ytlR 2.7.1.91 I Diacylglycerol kinase catalytic domain
APPPKGNO_00294 1.6e-42 rpmA J Belongs to the bacterial ribosomal protein bL27 family
APPPKGNO_00295 1e-27 ysxB J Cysteine protease Prp
APPPKGNO_00296 8.3e-48 rplU J This protein binds to 23S rRNA in the presence of protein L20
APPPKGNO_00299 2.9e-08 S Protein of unknown function (DUF2922)
APPPKGNO_00301 1.3e-16 K DNA-templated transcription, initiation
APPPKGNO_00303 1.1e-64 H Methyltransferase domain
APPPKGNO_00304 1.7e-75 cps2D 5.1.3.2 M RmlD substrate binding domain
APPPKGNO_00305 1.3e-40 wecD M Acetyltransferase (GNAT) family
APPPKGNO_00307 3.6e-26 ybl78 L Conserved phage C-terminus (Phg_2220_C)
APPPKGNO_00308 1.3e-40 S Protein of unknown function (DUF1211)
APPPKGNO_00309 5e-86 1.1.1.1 C Zinc-binding dehydrogenase
APPPKGNO_00310 2.7e-30 S CHY zinc finger
APPPKGNO_00311 2.1e-39 K Transcriptional regulator
APPPKGNO_00312 3.4e-83 qorB 1.6.5.2 GM NmrA-like family
APPPKGNO_00313 1.1e-07
APPPKGNO_00315 5.6e-126 M Glycosyl transferases group 1
APPPKGNO_00316 3.4e-64 M Glycosyl transferases group 1
APPPKGNO_00317 3.5e-166 ugd 1.1.1.22 M Belongs to the UDP-glucose GDP-mannose dehydrogenase family
APPPKGNO_00318 8e-146 lspL 5.1.3.6 GM RmlD substrate binding domain
APPPKGNO_00319 1.4e-103 cps2I S Psort location CytoplasmicMembrane, score
APPPKGNO_00320 2.3e-60 cps1B GT2,GT4 M Glycosyl transferases group 1
APPPKGNO_00321 8e-117 S Glycosyltransferase WbsX
APPPKGNO_00322 5.4e-53
APPPKGNO_00324 9.7e-57 pglI 2.4.1.293 GT2 M Glycosyltransferase like family 2
APPPKGNO_00325 3.3e-41 GT2 S Glycosyltransferase, group 2 family protein
APPPKGNO_00326 2.9e-74 M Glycosyltransferase Family 4
APPPKGNO_00327 3.2e-76 gtf1 2.4.1.52 GT4 M glycosyl transferase group 1
APPPKGNO_00328 3.6e-80 gtf1 2.4.1.52 GT4 M glycosyl transferase group 1
APPPKGNO_00329 1.2e-120 2.4.1.52 GT4 M Glycosyl transferases group 1
APPPKGNO_00330 2.2e-25 pglD 2.3.1.203 S Bacterial transferase hexapeptide (six repeats)
APPPKGNO_00331 1.6e-77 epsL M Bacterial sugar transferase
APPPKGNO_00332 2.8e-168 2.6.1.102 M Belongs to the DegT DnrJ EryC1 family
APPPKGNO_00333 1.6e-218 pglF 4.2.1.115, 4.2.1.135, 4.2.1.46 GM CoA-binding domain
APPPKGNO_00334 5.3e-48 cps4C M Chain length determinant protein
APPPKGNO_00335 3e-42 paiA 2.3.1.57 K Acetyltransferase (GNAT) domain
APPPKGNO_00336 1.3e-177 rsmF 2.1.1.176, 2.1.1.178 J NOL1 NOP2 sun family protein
APPPKGNO_00337 8.1e-81
APPPKGNO_00338 1.8e-83 yjfP S COG1073 Hydrolases of the alpha beta superfamily
APPPKGNO_00339 1e-113 yitU 3.1.3.104 S hydrolase
APPPKGNO_00340 6.2e-59 speG J Acetyltransferase (GNAT) domain
APPPKGNO_00341 2.6e-191 lysA 4.1.1.19, 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
APPPKGNO_00342 1.1e-23 dmpI 5.3.2.6 G Belongs to the 4-oxalocrotonate tautomerase family
APPPKGNO_00343 5e-204 pipD E Dipeptidase
APPPKGNO_00344 1.9e-44
APPPKGNO_00345 1.6e-64 K helix_turn_helix, arabinose operon control protein
APPPKGNO_00346 9.9e-53 S Membrane
APPPKGNO_00347 0.0 rafA 3.2.1.22 G alpha-galactosidase
APPPKGNO_00348 2.3e-59 yjaB 2.3.1.181 K Acetyltransferase (GNAT) domain
APPPKGNO_00349 2.2e-307 L Helicase C-terminal domain protein
APPPKGNO_00350 1.1e-50 nudG 3.6.1.55, 3.6.1.65 L NUDIX domain
APPPKGNO_00351 1.7e-38 yhjH 3.1.4.52 T Putative diguanylate phosphodiesterase
APPPKGNO_00352 1.4e-113 2.7.7.65 T diguanylate cyclase activity
APPPKGNO_00353 9.4e-222 ydaN S Bacterial cellulose synthase subunit
APPPKGNO_00354 3.9e-75 ydaN S Bacterial cellulose synthase subunit
APPPKGNO_00355 1.5e-201 ydaM M Glycosyl transferase family group 2
APPPKGNO_00356 6.5e-205 S Protein conserved in bacteria
APPPKGNO_00357 7.9e-181
APPPKGNO_00358 3.6e-127 G Belongs to the glycosyl hydrolase 8 (cellulase D) family
APPPKGNO_00359 4.9e-32 2.7.7.65 T GGDEF domain
APPPKGNO_00361 1.5e-146 pbuO_1 S Permease family
APPPKGNO_00362 1.9e-156 ndh 1.6.99.3 C NADH dehydrogenase
APPPKGNO_00363 2e-105 menA 2.5.1.74 H 1,4-dihydroxy-2-naphthoate
APPPKGNO_00364 2.4e-96 hepT 2.5.1.30, 2.5.1.90 H Belongs to the FPP GGPP synthase family
APPPKGNO_00365 2.3e-219 cydD CO ABC transporter transmembrane region
APPPKGNO_00366 2.7e-204 cydD CO ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydD
APPPKGNO_00367 2.5e-141 cydB 1.10.3.14 C Cytochrome d ubiquinol oxidase subunit II
APPPKGNO_00368 7.9e-194 cydA 1.10.3.14 C ubiquinol oxidase
APPPKGNO_00369 6.9e-160 asnA 6.3.1.1 F aspartate--ammonia ligase
APPPKGNO_00370 2.4e-27 xlyB 3.5.1.28 CBM50 M LysM domain
APPPKGNO_00371 5e-19 glpE P Rhodanese Homology Domain
APPPKGNO_00372 4.2e-49 lytE M LysM domain protein
APPPKGNO_00373 1.4e-92 T Calcineurin-like phosphoesterase superfamily domain
APPPKGNO_00374 5.7e-85 2.7.7.12 C Domain of unknown function (DUF4931)
APPPKGNO_00376 4.4e-74 draG O ADP-ribosylglycohydrolase
APPPKGNO_00377 2.5e-102 S Uncharacterised 5xTM membrane BCR, YitT family COG1284
APPPKGNO_00378 0.0 ileS 6.1.1.5 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
APPPKGNO_00379 1.1e-61 divIVA D DivIVA domain protein
APPPKGNO_00380 1.7e-81 ylmH S S4 domain protein
APPPKGNO_00381 3e-19 yggT S YGGT family
APPPKGNO_00382 5e-33 sepF D Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
APPPKGNO_00383 9.8e-180 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
APPPKGNO_00384 5.2e-190 ftsA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
APPPKGNO_00385 1.3e-61 divIB D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
APPPKGNO_00386 1.2e-152 murG 2.4.1.227, 6.3.2.8 GT28 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
APPPKGNO_00387 3.2e-184 murD 6.3.2.9 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
APPPKGNO_00388 8.7e-136 mraY 2.7.8.13 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APPPKGNO_00389 4e-282 ftsI 3.4.16.4 M Penicillin-binding Protein
APPPKGNO_00390 2.5e-11 ftsL D cell division protein FtsL
APPPKGNO_00391 8e-142 rsmH 2.1.1.199 J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
APPPKGNO_00392 1.5e-55 mraZ K Belongs to the MraZ family
APPPKGNO_00393 2.2e-07 S Protein of unknown function (DUF3397)
APPPKGNO_00394 1.2e-155 dapG 1.1.1.3, 2.7.2.4 E Amino acid kinase family
APPPKGNO_00396 9.8e-100 D Alpha beta
APPPKGNO_00397 3.7e-109 aatB ET ABC transporter substrate-binding protein
APPPKGNO_00398 1.8e-89 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
APPPKGNO_00399 1.9e-94 glnP P ABC transporter permease
APPPKGNO_00400 1.8e-126 minD D Belongs to the ParA family
APPPKGNO_00401 8.3e-77 minC D Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization
APPPKGNO_00402 1.5e-54 mreD M rod shape-determining protein MreD
APPPKGNO_00403 2.1e-88 mreC M Involved in formation and maintenance of cell shape
APPPKGNO_00404 3.6e-156 mreB D cell shape determining protein MreB
APPPKGNO_00405 4.5e-21 K Cold shock
APPPKGNO_00406 3.1e-79 radC L DNA repair protein
APPPKGNO_00407 1.1e-136 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
APPPKGNO_00408 0.0 valS 6.1.1.9 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
APPPKGNO_00409 1.9e-196 thiI 2.8.1.4 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APPPKGNO_00410 6.4e-162 iscS2 2.8.1.7 E Aminotransferase class V
APPPKGNO_00411 1.3e-174 ezrA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
APPPKGNO_00412 7.1e-56 ytsP 1.8.4.14 T GAF domain-containing protein
APPPKGNO_00413 7.5e-101 rpsD J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
APPPKGNO_00414 3.4e-24 yueI S Protein of unknown function (DUF1694)
APPPKGNO_00415 5.1e-184 rarA L recombination factor protein RarA
APPPKGNO_00417 3.2e-73 usp6 T universal stress protein
APPPKGNO_00418 3.7e-54 tag 3.2.2.20 L glycosylase
APPPKGNO_00419 7.7e-200 ddl 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
APPPKGNO_00420 5.9e-125 pepP 3.4.11.9, 3.4.13.9 E Creatinase/Prolidase N-terminal domain
APPPKGNO_00422 3.3e-75 yviA S Protein of unknown function (DUF421)
APPPKGNO_00423 1.8e-27 S Protein of unknown function (DUF3290)
APPPKGNO_00424 2.3e-279 pbp2b 3.4.16.4 M Penicillin-binding Protein
APPPKGNO_00425 1.2e-296 S membrane
APPPKGNO_00426 1.3e-80 apt 2.4.2.7 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APPPKGNO_00427 1.5e-218 recJ L Single-stranded-DNA-specific exonuclease RecJ
APPPKGNO_00428 6.5e-100 XK27_05435 1.1.1.100 S Enoyl-(Acyl carrier protein) reductase
APPPKGNO_00429 8.9e-141 rnz 3.1.26.11 J Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
APPPKGNO_00431 1.4e-16
APPPKGNO_00432 2.1e-199 oatA I Acyltransferase
APPPKGNO_00433 1.8e-213 obg S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
APPPKGNO_00434 2.8e-305 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
APPPKGNO_00435 1.2e-140 hprA 1.1.1.29 C Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APPPKGNO_00438 5.1e-42 S Phosphoesterase
APPPKGNO_00439 2.2e-73 rdgB 3.6.1.66, 5.1.1.3 F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APPPKGNO_00440 1.1e-60 yslB S Protein of unknown function (DUF2507)
APPPKGNO_00441 9.9e-41 trxA O Belongs to the thioredoxin family
APPPKGNO_00442 3.9e-310 mutS2 L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
APPPKGNO_00443 7.5e-15 cvpA S Colicin V production protein
APPPKGNO_00444 1.4e-15 zapA D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
APPPKGNO_00445 1.9e-33 yrzB S Belongs to the UPF0473 family
APPPKGNO_00446 1e-59 yqgF J Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
APPPKGNO_00447 2.1e-36 yrzL S Belongs to the UPF0297 family
APPPKGNO_00448 0.0 alaS 6.1.1.7 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APPPKGNO_00449 3.9e-187 cshB 3.6.4.13 JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
APPPKGNO_00450 2.1e-121 nrnA 3.1.13.3, 3.1.3.7 S DHHA1 domain protein
APPPKGNO_00451 7.5e-13
APPPKGNO_00452 2.1e-147 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
APPPKGNO_00453 3.2e-66 yrjD S LUD domain
APPPKGNO_00454 2.1e-245 lutB C 4Fe-4S dicluster domain
APPPKGNO_00455 6.9e-117 lutA C Cysteine-rich domain
APPPKGNO_00456 2e-208 yfnA E Amino Acid
APPPKGNO_00458 4.3e-61 uspA T universal stress protein
APPPKGNO_00460 1.8e-12 yajC U Preprotein translocase
APPPKGNO_00461 2.9e-207 tgt 2.4.2.29 F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
APPPKGNO_00462 2.1e-183 queA 2.4.99.17 J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
APPPKGNO_00463 6.3e-153 ruvB 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
APPPKGNO_00464 7.3e-72 ruvA 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
APPPKGNO_00465 6e-224 mutL L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
APPPKGNO_00466 0.0 mutS L that it carries out the mismatch recognition step. This protein has a weak ATPase activity
APPPKGNO_00467 2.6e-182 rny S Endoribonuclease that initiates mRNA decay
APPPKGNO_00468 2.3e-159 recA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
APPPKGNO_00469 4.3e-85 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
APPPKGNO_00470 2.9e-64 ymfM S Helix-turn-helix domain
APPPKGNO_00471 8.4e-91 IQ Enoyl-(Acyl carrier protein) reductase
APPPKGNO_00472 3.4e-52 ymfH S Peptidase M16
APPPKGNO_00473 1.7e-91 ymfH S Peptidase M16
APPPKGNO_00474 3.5e-108 ymfF S Peptidase M16 inactive domain protein
APPPKGNO_00475 1.6e-284 ftsK D Belongs to the FtsK SpoIIIE SftA family
APPPKGNO_00476 4.4e-86 trmL 2.1.1.207 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
APPPKGNO_00477 1.7e-98 rrmA 2.1.1.187 H Methyltransferase
APPPKGNO_00478 4.9e-61 ybaK J Aminoacyl-tRNA editing domain
APPPKGNO_00479 5.9e-164 guaC 1.1.1.205, 1.7.1.7 F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
APPPKGNO_00480 4.3e-169 gltP U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
APPPKGNO_00481 3.2e-21 cutC P Participates in the control of copper homeostasis
APPPKGNO_00482 3.4e-130 pgl 3.1.1.31 G Lactonase, 7-bladed beta-propeller
APPPKGNO_00483 7.5e-29 srlB 2.7.1.198 G PTS system glucitol/sorbitol-specific IIA component
APPPKGNO_00484 2.6e-226 glmM 5.4.2.10 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APPPKGNO_00485 5.3e-68 ybbR S YbbR-like protein
APPPKGNO_00486 8.5e-127 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
APPPKGNO_00487 2.4e-71 S Protein of unknown function (DUF1361)
APPPKGNO_00488 1.2e-115 murB 1.3.1.98 M Cell wall formation
APPPKGNO_00489 3e-69 dnaQ 2.7.7.7 L DNA polymerase III
APPPKGNO_00490 2.5e-56 ydiB 2.7.1.221, 5.1.1.1 O Hydrolase, P-loop family
APPPKGNO_00491 2e-143 pta 2.3.1.8, 3.6.3.21 C phosphate acetyltransferase
APPPKGNO_00492 5.2e-106 ung 3.2.2.27 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
APPPKGNO_00493 1.8e-116 ycsE S Sucrose-6F-phosphate phosphohydrolase
APPPKGNO_00494 9.1e-42 yxjI
APPPKGNO_00495 9e-70 smpB J the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
APPPKGNO_00496 0.0 rnr J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
APPPKGNO_00497 2.8e-19 secG U Preprotein translocase
APPPKGNO_00498 7e-180 clcA P chloride
APPPKGNO_00499 6.7e-146 lmrP E Major Facilitator Superfamily
APPPKGNO_00500 1.8e-169 T PhoQ Sensor
APPPKGNO_00501 5e-104 K response regulator
APPPKGNO_00502 3.3e-119 dinB 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APPPKGNO_00503 9.5e-234 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
APPPKGNO_00504 2.3e-128 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
APPPKGNO_00505 1.3e-208 pgk 2.7.2.3, 5.3.1.1 F Belongs to the phosphoglycerate kinase family
APPPKGNO_00506 6.1e-180 gap 1.2.1.12 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
APPPKGNO_00507 1.1e-136 cggR K Putative sugar-binding domain
APPPKGNO_00509 1.1e-99 clpP 3.4.21.92 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
APPPKGNO_00510 6.7e-149 whiA K May be required for sporulation
APPPKGNO_00511 8.2e-153 ybhK S Required for morphogenesis under gluconeogenic growth conditions
APPPKGNO_00512 7.5e-126 rapZ S Displays ATPase and GTPase activities
APPPKGNO_00513 2.7e-36 ylbE GM NAD dependent epimerase dehydratase family protein
APPPKGNO_00514 2.9e-32 ylbE GM NAD(P)H-binding
APPPKGNO_00515 1.1e-83 luxS 4.4.1.21 H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
APPPKGNO_00516 0.0 uvrA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
APPPKGNO_00517 0.0 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
APPPKGNO_00518 3.9e-272 pgm 5.4.2.2, 5.4.2.8 G Phosphoglucomutase phosphomannomutase, alpha beta alpha domain
APPPKGNO_00519 1.9e-112 lgt 2.1.1.199 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
APPPKGNO_00520 9.6e-132 hprK F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
APPPKGNO_00521 1.6e-26 yvlD S Mycobacterial 4 TMS phage holin, superfamily IV
APPPKGNO_00522 3.2e-08 KT PspC domain protein
APPPKGNO_00523 3.5e-85 phoR 2.7.13.3 T Histidine kinase
APPPKGNO_00524 4.6e-86 K response regulator
APPPKGNO_00525 4.1e-68 minJ O Domain present in PSD-95, Dlg, and ZO-1/2.
APPPKGNO_00526 1.2e-162 prfB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APPPKGNO_00527 0.0 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
APPPKGNO_00528 1.7e-96 yeaN P Major Facilitator Superfamily
APPPKGNO_00529 6e-81 hpf J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
APPPKGNO_00530 1e-45 comFC S Competence protein
APPPKGNO_00531 4.6e-127 comFA L Helicase C-terminal domain protein
APPPKGNO_00532 1.6e-157 tagO 2.7.8.33, 2.7.8.35 M transferase
APPPKGNO_00533 4.1e-296 ydaO E amino acid
APPPKGNO_00534 2.8e-268 aha1 P COG COG0474 Cation transport ATPase
APPPKGNO_00535 3.7e-272 groL O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
APPPKGNO_00536 2.4e-33 groS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
APPPKGNO_00537 8.2e-34 S CAAX protease self-immunity
APPPKGNO_00538 1.3e-98 rex K Modulates transcription in response to changes in cellular NADH NAD( ) redox state
APPPKGNO_00539 1.9e-254 uup S ABC transporter, ATP-binding protein
APPPKGNO_00540 2.9e-161 tsaD 2.3.1.234 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
APPPKGNO_00541 4.3e-28 rimI 2.3.1.128 K Ribosomal-protein-alanine acetyltransferase
APPPKGNO_00542 2.8e-70 yeaZ 2.3.1.234 O Universal bacterial protein YeaZ
APPPKGNO_00543 1.6e-140 ansA 3.5.1.1 EJ Asparaginase
APPPKGNO_00544 5.5e-82 fat 3.1.2.21 I Acyl-ACP thioesterase
APPPKGNO_00545 3.2e-92 rsmI 2.1.1.198 H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
APPPKGNO_00546 1.4e-40 yabA L Involved in initiation control of chromosome replication
APPPKGNO_00547 5.2e-83 holB 2.7.7.7 L DNA polymerase III
APPPKGNO_00548 1.8e-65 tmk 2.7.4.9 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APPPKGNO_00549 9.2e-29 yaaL S Protein of unknown function (DUF2508)
APPPKGNO_00550 2.2e-97 recR L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
APPPKGNO_00551 7e-34 yaaK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
APPPKGNO_00552 5.1e-211 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APPPKGNO_00553 3.3e-62 tadA 3.5.4.33 F Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
APPPKGNO_00554 6.4e-76 rsmC 2.1.1.172 J Methyltransferase
APPPKGNO_00555 3.5e-27 nrdH O Glutaredoxin
APPPKGNO_00556 4.8e-45 nrdI F NrdI Flavodoxin like
APPPKGNO_00557 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APPPKGNO_00558 1e-160 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APPPKGNO_00559 2.1e-301 mprF 2.3.2.3 S Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
APPPKGNO_00560 1.4e-54
APPPKGNO_00561 2.6e-48 rplL J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
APPPKGNO_00562 7.6e-75 rplJ J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
APPPKGNO_00563 1.6e-115 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
APPPKGNO_00564 5e-67 rplK J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
APPPKGNO_00565 7.7e-84 nusG K Participates in transcription elongation, termination and antitermination
APPPKGNO_00566 2.6e-11 secE U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
APPPKGNO_00567 2.1e-20 rpmG J Belongs to the bacterial ribosomal protein bL33 family
APPPKGNO_00568 7e-71 yacP S YacP-like NYN domain
APPPKGNO_00569 1.6e-108 rlmB 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APPPKGNO_00570 6.4e-56 mrnC J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
APPPKGNO_00571 3.6e-207 cysS 6.1.1.16, 6.3.1.13 J Belongs to the class-I aminoacyl-tRNA synthetase family
APPPKGNO_00572 2.9e-247 gltX 6.1.1.17, 6.1.1.24 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APPPKGNO_00573 8.2e-154 yacL S domain protein
APPPKGNO_00574 1e-222 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
APPPKGNO_00575 6.9e-74 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F dUTP diphosphatase
APPPKGNO_00576 4.3e-19 HA62_12640 S GCN5-related N-acetyl-transferase
APPPKGNO_00577 5.8e-223 pepC 3.4.22.40 E Peptidase C1-like family
APPPKGNO_00578 1e-33 S Enterocin A Immunity
APPPKGNO_00579 2.9e-85 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
APPPKGNO_00580 4.5e-129 mleP2 S Sodium Bile acid symporter family
APPPKGNO_00581 4.6e-116 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APPPKGNO_00583 3e-43 ydcK S Belongs to the SprT family
APPPKGNO_00584 4.4e-252 yhgF K Tex-like protein N-terminal domain protein
APPPKGNO_00585 1e-129 nadE 6.3.1.5 F Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
APPPKGNO_00586 3.3e-243 pncB 6.3.4.21 F Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
APPPKGNO_00587 2.1e-89 tagA 2.4.1.187 GT26 F Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid
APPPKGNO_00588 4.9e-96 gntR1 K UbiC transcription regulator-associated domain protein
APPPKGNO_00589 1e-89 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
APPPKGNO_00591 1.1e-07
APPPKGNO_00592 1.6e-197 dtpT U amino acid peptide transporter
APPPKGNO_00593 3.8e-93 yihY S Belongs to the UPF0761 family
APPPKGNO_00594 6.2e-12 mltD CBM50 M Lysin motif
APPPKGNO_00595 1.2e-152 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
APPPKGNO_00596 1.2e-143 map 3.4.11.18 E Methionine Aminopeptidase
APPPKGNO_00597 5.1e-54 fld C Flavodoxin
APPPKGNO_00598 8.7e-53 gtcA S Teichoic acid glycosylation protein
APPPKGNO_00599 0.0 S Bacterial membrane protein YfhO
APPPKGNO_00600 5.2e-120 rapL 4.3.1.12 E Ornithine cyclodeaminase/mu-crystallin family
APPPKGNO_00601 1.7e-122 S Sulfite exporter TauE/SafE
APPPKGNO_00602 2.4e-70 K Sugar-specific transcriptional regulator TrmB
APPPKGNO_00603 1e-167 mnaA 5.1.3.14 G Belongs to the UDP-N-acetylglucosamine 2-epimerase family
APPPKGNO_00604 6e-182 pepS E Thermophilic metalloprotease (M29)
APPPKGNO_00605 3e-266 E Amino acid permease
APPPKGNO_00606 4.9e-85 pgmB 2.4.1.64, 3.1.3.12, 3.2.1.28, 5.4.2.6 GH37,GH65 S beta-phosphoglucomutase
APPPKGNO_00607 0.0 mapA 2.4.1.8 GH65 G hydrolase, family 65, central catalytic
APPPKGNO_00608 7.7e-79 galM 5.1.3.3 G Aldose 1-epimerase
APPPKGNO_00609 4.3e-213 malT G Transporter, major facilitator family protein
APPPKGNO_00610 4.7e-100 malR K Transcriptional regulator, LacI family
APPPKGNO_00611 2.3e-279 kup P Transport of potassium into the cell
APPPKGNO_00613 2e-20 S Domain of unknown function (DUF3284)
APPPKGNO_00614 5.2e-160 yfmL L DEAD DEAH box helicase
APPPKGNO_00615 1.6e-127 mocA S Oxidoreductase
APPPKGNO_00616 2e-24 S Domain of unknown function (DUF4828)
APPPKGNO_00617 1.2e-175 malQ 2.4.1.25, 3.2.1.20, 3.2.1.41 CBM48,GH13,GH31,GH77 G Belongs to the glycosyl hydrolase 13 family
APPPKGNO_00618 0.0 glgP 2.4.1.1 GT35 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
APPPKGNO_00619 4.7e-194 glgA 2.4.1.21 GT5 F Synthesizes alpha-1,4-glucan chains using ADP-glucose
APPPKGNO_00620 1.4e-119 glgD 2.4.1.21, 2.7.7.27 GT5 G Nucleotidyl transferase
APPPKGNO_00621 7.1e-161 glgC 2.7.7.27 H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APPPKGNO_00622 3.6e-266 glgB 2.4.1.18, 3.2.1.141, 3.2.1.20 CBM48,GH13,GH31 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APPPKGNO_00623 8.5e-222 nplT 3.2.1.133, 3.2.1.135, 3.2.1.54 GH13 G Belongs to the glycosyl hydrolase 13 family
APPPKGNO_00624 1.1e-41 O ADP-ribosylglycohydrolase
APPPKGNO_00625 5.5e-221 gdhA 1.4.1.4 E Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
APPPKGNO_00626 2.9e-209 gabD 1.2.1.16, 1.2.1.20, 1.2.1.79 C Belongs to the aldehyde dehydrogenase family
APPPKGNO_00627 1.3e-34 K GNAT family
APPPKGNO_00628 1.7e-40
APPPKGNO_00630 2.1e-159 mgtE P Acts as a magnesium transporter
APPPKGNO_00631 9.7e-94 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 G Responsible for synthesis of pseudouridine from uracil
APPPKGNO_00632 7.6e-117 nadK 2.7.1.23 F Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
APPPKGNO_00633 2.5e-94 yjbM 2.7.6.5 S RelA SpoT domain protein
APPPKGNO_00634 2.7e-259 topB 5.99.1.2 L This gene contains a nucleotide ambiguity which may be the result of a sequencing error
APPPKGNO_00635 9.1e-34 maa 2.3.1.18, 2.3.1.79 S Maltose acetyltransferase
APPPKGNO_00636 9.7e-194 pbuX F xanthine permease
APPPKGNO_00637 3.3e-74 xpt 2.4.2.22, 2.4.2.7 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
APPPKGNO_00638 4.1e-60 acmC 3.2.1.96 NU mannosyl-glycoprotein
APPPKGNO_00639 9.4e-64 S ECF transporter, substrate-specific component
APPPKGNO_00640 3.3e-127 mleP S Sodium Bile acid symporter family
APPPKGNO_00641 1.7e-248 sfcA 1.1.1.38, 4.1.1.101 C Malic enzyme
APPPKGNO_00642 6.2e-72 mleR K LysR family
APPPKGNO_00643 1.1e-56 K transcriptional
APPPKGNO_00644 3.4e-41 K Bacterial regulatory proteins, tetR family
APPPKGNO_00645 1.8e-59 T Belongs to the universal stress protein A family
APPPKGNO_00646 3.6e-44 K Copper transport repressor CopY TcrY
APPPKGNO_00647 3.5e-230 3.2.1.18 GH33 M Rib/alpha-like repeat
APPPKGNO_00649 1.8e-95 ypuA S Protein of unknown function (DUF1002)
APPPKGNO_00650 8.4e-60 dedA 3.1.3.1 S SNARE associated Golgi protein
APPPKGNO_00651 3e-162 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
APPPKGNO_00652 1.1e-34 yncA 2.3.1.79 S Maltose acetyltransferase
APPPKGNO_00653 6.9e-206 yflS P Sodium:sulfate symporter transmembrane region
APPPKGNO_00654 1.2e-199 frdC 1.3.5.4 C FAD binding domain
APPPKGNO_00655 3.3e-237 fumC 4.2.1.2 C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
APPPKGNO_00656 2e-14 ybaN S Protein of unknown function (DUF454)
APPPKGNO_00657 8.2e-177 merA 1.16.1.1, 1.8.1.7 C Pyridine nucleotide-disulfide oxidoreductase
APPPKGNO_00658 2.6e-57 spxA 1.20.4.1 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
APPPKGNO_00659 3.6e-96 nrdG 1.97.1.4 O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APPPKGNO_00660 0.0 nrdD 1.1.98.6 F Ribonucleoside-triphosphate reductase
APPPKGNO_00661 1.1e-71 ywlG S Belongs to the UPF0340 family
APPPKGNO_00662 7.3e-67 S Acetyltransferase (GNAT) domain
APPPKGNO_00663 9.2e-14 ftsZ M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
APPPKGNO_00666 2.3e-173 spoVK O PFAM ATPase family associated with various cellular activities (AAA)
APPPKGNO_00667 3e-230 yfjM S Protein of unknown function DUF262
APPPKGNO_00668 8.5e-73 S Domain of unknown function (DUF3841)
APPPKGNO_00669 1.6e-56 cdd 2.4.2.4, 3.5.4.5 F Cytidine and deoxycytidylate deaminase zinc-binding region
APPPKGNO_00670 4.2e-302 hsdM 2.1.1.72 V Type I restriction-modification system
APPPKGNO_00671 1.4e-208 rumA 2.1.1.190 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APPPKGNO_00672 3.4e-146 yegS 2.7.1.107 G Lipid kinase
APPPKGNO_00673 1.9e-256 gatB 6.1.1.12, 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APPPKGNO_00674 3.1e-233 gatA 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
APPPKGNO_00675 7.6e-38 gatC 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APPPKGNO_00676 1.2e-160 camS S sex pheromone
APPPKGNO_00677 3.9e-279 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APPPKGNO_00678 0.0 pcrA 3.6.4.12 L ATP-dependent DNA helicase
APPPKGNO_00679 4.2e-145 purK2 6.3.4.18 F Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
APPPKGNO_00682 5.1e-260 lysS 6.1.1.6 J Belongs to the class-II aminoacyl-tRNA synthetase family
APPPKGNO_00683 1.6e-169 dus J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APPPKGNO_00684 2.4e-132 hslO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
APPPKGNO_00685 3e-282 ftsH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APPPKGNO_00686 1.5e-76 hpt 2.4.2.8 F Belongs to the purine pyrimidine phosphoribosyltransferase family
APPPKGNO_00687 5.5e-96 tilS 2.4.2.8, 6.3.4.19 J Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
APPPKGNO_00688 1.1e-40 yabR J RNA binding
APPPKGNO_00689 1.3e-21 divIC D Septum formation initiator
APPPKGNO_00690 3.6e-31 yabO J S4 domain protein
APPPKGNO_00691 7.3e-140 yabM S Polysaccharide biosynthesis protein
APPPKGNO_00692 0.0 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APPPKGNO_00693 6.5e-75 pth 3.1.1.29 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
APPPKGNO_00694 6.2e-158 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
APPPKGNO_00695 2.5e-86 S (CBS) domain
APPPKGNO_00696 4e-141 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
APPPKGNO_00697 3.2e-207 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
APPPKGNO_00698 1e-51 perR P Belongs to the Fur family
APPPKGNO_00699 7.6e-58 S LexA-binding, inner membrane-associated putative hydrolase
APPPKGNO_00700 6.7e-97 sbcC L Putative exonuclease SbcCD, C subunit
APPPKGNO_00701 1.1e-113 sbcD L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
APPPKGNO_00702 2.1e-36 M LysM domain protein
APPPKGNO_00703 3e-278 poxB 1.2.3.3, 1.2.5.1 EH Belongs to the TPP enzyme family
APPPKGNO_00704 7e-85 ddpX 3.4.13.22 E Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
APPPKGNO_00705 2e-35 ygfC K Bacterial regulatory proteins, tetR family
APPPKGNO_00706 5.9e-101 hrtB V ABC transporter permease
APPPKGNO_00707 1.5e-86 devA 3.6.3.25 V ABC transporter, ATP-binding protein
APPPKGNO_00708 3e-67 nfrA 1.5.1.38, 1.5.1.39 C nitroreductase
APPPKGNO_00709 0.0 helD 3.6.4.12 L DNA helicase
APPPKGNO_00710 8.9e-246 yjbQ P TrkA C-terminal domain protein
APPPKGNO_00711 3.4e-23
APPPKGNO_00712 1.1e-60 rpsI J Belongs to the universal ribosomal protein uS9 family
APPPKGNO_00713 5.5e-77 rplM J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
APPPKGNO_00714 2.5e-125 truA 5.4.99.12 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
APPPKGNO_00715 2.8e-108 ecfT U Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
APPPKGNO_00716 6.7e-111 ecfA2 3.6.3.55 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
APPPKGNO_00717 1.8e-100 ecfA1 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
APPPKGNO_00718 4.8e-53 rplQ J Ribosomal protein L17
APPPKGNO_00719 1.3e-155 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APPPKGNO_00720 2.3e-63 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APPPKGNO_00721 4.4e-56 rpsM J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APPPKGNO_00722 2.5e-13 rpmJ J Belongs to the bacterial ribosomal protein bL36 family
APPPKGNO_00723 4.8e-34 infA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
APPPKGNO_00724 4.4e-107 adk 2.7.4.3 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
APPPKGNO_00725 4.4e-207 secY U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
APPPKGNO_00726 1e-67 rplO J Binds to the 23S rRNA
APPPKGNO_00727 2.1e-22 rpmD J Ribosomal protein L30
APPPKGNO_00728 1.3e-82 rpsE J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
APPPKGNO_00729 9.6e-56 rplR J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
APPPKGNO_00730 3.2e-87 rplF J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
APPPKGNO_00731 2.5e-65 rpsH J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
APPPKGNO_00732 4.4e-28 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APPPKGNO_00733 1.3e-91 rplE J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APPPKGNO_00734 7e-47 rplX J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
APPPKGNO_00735 5.1e-60 rplN J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
APPPKGNO_00736 8e-39 rpsQ J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
APPPKGNO_00737 9e-24 rpmC J Belongs to the universal ribosomal protein uL29 family
APPPKGNO_00738 6.2e-73 rplP J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
APPPKGNO_00739 5.2e-116 rpsC J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
APPPKGNO_00740 1.5e-53 rplV J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
APPPKGNO_00741 1e-44 rpsS J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
APPPKGNO_00742 1.4e-142 rplB J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
APPPKGNO_00743 2.9e-39 rplW J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
APPPKGNO_00744 1e-100 rplD J Forms part of the polypeptide exit tunnel
APPPKGNO_00745 4.5e-109 rplC J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
APPPKGNO_00746 2e-49 rpsJ J Involved in the binding of tRNA to the ribosomes
APPPKGNO_00747 5.6e-167 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APPPKGNO_00748 2.5e-78 K rpiR family
APPPKGNO_00749 5.9e-54 rpiA 5.3.1.6 G Ribose 5-phosphate isomerase A (phosphoriboisomerase A)
APPPKGNO_00750 1.1e-146 XK27_10475 S Oxidoreductase family, NAD-binding Rossmann fold
APPPKGNO_00751 6.5e-21 K Acetyltransferase (GNAT) domain
APPPKGNO_00752 2.9e-182 steT E amino acid
APPPKGNO_00753 9.6e-78 glnP P ABC transporter permease
APPPKGNO_00754 1.2e-85 gluC P ABC transporter permease
APPPKGNO_00755 6.6e-100 glnH ET ABC transporter
APPPKGNO_00756 1.3e-102 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
APPPKGNO_00757 3.9e-08
APPPKGNO_00758 2.2e-98
APPPKGNO_00760 3.2e-53 zur P Belongs to the Fur family
APPPKGNO_00761 2.2e-212 yfnA E Amino Acid
APPPKGNO_00762 9.6e-251 guaB 1.1.1.205 F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
APPPKGNO_00763 0.0 L Helicase C-terminal domain protein
APPPKGNO_00764 6e-79 ptp2 3.1.3.48 T Tyrosine phosphatase family
APPPKGNO_00765 2.1e-180 yhdP S Transporter associated domain
APPPKGNO_00766 1.7e-26
APPPKGNO_00767 5.3e-74 rluA 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
APPPKGNO_00768 3.7e-131 bacI V MacB-like periplasmic core domain
APPPKGNO_00769 7.4e-97 V ABC transporter
APPPKGNO_00770 2.6e-64 bacG M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APPPKGNO_00771 1.4e-156 gmuE 2.7.1.2, 2.7.1.4 GK ROK family
APPPKGNO_00772 6.2e-140 V MatE
APPPKGNO_00773 3.5e-43 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
APPPKGNO_00774 2.1e-85 S Alpha beta hydrolase
APPPKGNO_00775 7.1e-95 nagB 3.1.1.31, 3.5.99.6 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
APPPKGNO_00776 1.9e-174 nagA 3.5.1.25 G Belongs to the metallo-dependent hydrolases superfamily. NagA family
APPPKGNO_00777 1e-111 argE 3.5.1.18 E Peptidase dimerisation domain
APPPKGNO_00778 8.4e-102 IQ Enoyl-(Acyl carrier protein) reductase
APPPKGNO_00779 3.9e-34 XK27_01315 S Protein of unknown function (DUF2829)
APPPKGNO_00780 8.1e-53 queT S QueT transporter
APPPKGNO_00782 1.1e-65 degV S Uncharacterised protein, DegV family COG1307
APPPKGNO_00783 8.8e-22 crcB U Important for reducing fluoride concentration in the cell, thus reducing its toxicity
APPPKGNO_00784 9.4e-22 crcB U Important for reducing fluoride concentration in the cell, thus reducing its toxicity
APPPKGNO_00785 3.2e-34 trxA O Belongs to the thioredoxin family
APPPKGNO_00786 1.4e-86 S Sucrose-6F-phosphate phosphohydrolase
APPPKGNO_00787 2.8e-125 brpA K Cell envelope-like function transcriptional attenuator common domain protein
APPPKGNO_00788 2.8e-49 S Threonine/Serine exporter, ThrE
APPPKGNO_00789 4.3e-82 thrE S Putative threonine/serine exporter
APPPKGNO_00790 3.1e-27 cspC K Cold shock protein
APPPKGNO_00791 8.3e-90 sirR K Helix-turn-helix diphteria tox regulatory element
APPPKGNO_00792 3.8e-93 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 J Responsible for synthesis of pseudouridine from uracil
APPPKGNO_00793 5.4e-23
APPPKGNO_00794 1.2e-58 3.6.1.27 I phosphatase
APPPKGNO_00795 1.2e-24
APPPKGNO_00796 1.8e-65 I alpha/beta hydrolase fold
APPPKGNO_00797 1.3e-38 azlD S branched-chain amino acid
APPPKGNO_00798 1.1e-104 azlC E AzlC protein
APPPKGNO_00799 1.3e-16
APPPKGNO_00800 1.3e-119 xth 3.1.11.2 L exodeoxyribonuclease III
APPPKGNO_00801 3.8e-99 V domain protein
APPPKGNO_00802 1.9e-09
APPPKGNO_00804 6e-123 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
APPPKGNO_00805 5.4e-172 malY 4.4.1.8 E Aminotransferase, class I
APPPKGNO_00806 2.4e-118 K AI-2E family transporter
APPPKGNO_00807 5.2e-61 EG EamA-like transporter family
APPPKGNO_00808 1.1e-75 L haloacid dehalogenase-like hydrolase
APPPKGNO_00809 1.5e-117 galM 5.1.3.3 G Catalyzes the interconversion of alpha and beta anomers of maltose
APPPKGNO_00810 1.8e-67 1.5.1.38 S NADPH-dependent FMN reductase
APPPKGNO_00811 3.7e-164 C Luciferase-like monooxygenase
APPPKGNO_00812 1.3e-41 K Transcriptional regulator, HxlR family
APPPKGNO_00813 1.7e-171 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
APPPKGNO_00814 6.2e-102 ydhQ K UbiC transcription regulator-associated domain protein
APPPKGNO_00815 0.0 xfp 4.1.2.22, 4.1.2.9 G Phosphoketolase
APPPKGNO_00816 2.4e-82 pncA Q isochorismatase
APPPKGNO_00817 3.5e-63 3.1.3.73 G phosphoglycerate mutase
APPPKGNO_00818 4e-104 treB G phosphotransferase system
APPPKGNO_00819 1.1e-147 treC 3.2.1.93 GH13 G Alpha amylase, catalytic domain protein
APPPKGNO_00820 1.9e-167 mdtG EGP Major facilitator Superfamily
APPPKGNO_00822 5.6e-194 XK27_08315 M Sulfatase
APPPKGNO_00823 1.6e-47 3.5.1.28 M N-acetylmuramoyl-L-alanine amidase
APPPKGNO_00824 5.6e-89 thrB 2.7.1.39 F Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
APPPKGNO_00825 8.8e-168 hom 1.1.1.3, 2.7.2.4 E homoserine dehydrogenase
APPPKGNO_00826 3.4e-127 apbE 2.7.1.180 H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
APPPKGNO_00827 4.1e-177 thrC 4.2.3.1 E Threonine synthase
APPPKGNO_00828 9.7e-75 3.2.1.17 NU Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
APPPKGNO_00829 6.2e-62 S Psort location CytoplasmicMembrane, score
APPPKGNO_00830 1.3e-87 waaB GT4 M Glycosyl transferases group 1
APPPKGNO_00831 1.4e-58 cps3F
APPPKGNO_00832 5.3e-70 M Domain of unknown function (DUF4422)
APPPKGNO_00833 4.8e-161 XK27_08315 M Sulfatase
APPPKGNO_00834 6.5e-130 S Bacterial membrane protein YfhO
APPPKGNO_00835 3.6e-14
APPPKGNO_00836 1.4e-54 cps3I G Acyltransferase family
APPPKGNO_00837 1.1e-146 iunH 3.2.2.1 F Inosine-uridine preferring nucleoside hydrolase
APPPKGNO_00838 4.4e-39 2.7.7.65 T phosphorelay sensor kinase activity
APPPKGNO_00839 1.1e-157 XK27_09615 S reductase
APPPKGNO_00840 1.9e-67 XK27_09620 S NADPH-dependent FMN reductase
APPPKGNO_00841 1.8e-95 dacA 3.4.16.4 M Belongs to the peptidase S11 family
APPPKGNO_00842 2.8e-160 napA P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
APPPKGNO_00843 0.0 pepX 3.4.14.11 E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline
APPPKGNO_00844 1.2e-74 G Peptidase_C39 like family
APPPKGNO_00845 8.3e-48 M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
APPPKGNO_00846 1e-274 guaA 2.3.1.128, 6.3.5.2 F Catalyzes the synthesis of GMP from XMP
APPPKGNO_00847 2.3e-133 coaA 2.7.1.33 F Pantothenic acid kinase
APPPKGNO_00848 3.5e-42 E lipolytic protein G-D-S-L family
APPPKGNO_00849 2.3e-112 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
APPPKGNO_00850 2.1e-189 glnPH2 P ABC transporter permease
APPPKGNO_00851 2.1e-213 yjeM E Amino Acid
APPPKGNO_00852 1.8e-32 yvdC S MazG nucleotide pyrophosphohydrolase domain
APPPKGNO_00853 5.1e-138 tetA EGP Major facilitator Superfamily
APPPKGNO_00855 3.1e-70 rny D Peptidase family M23
APPPKGNO_00856 8.5e-188 cps1C S Membrane protein involved in the export of O-antigen and teichoic acid
APPPKGNO_00857 1.1e-193 glf 5.4.99.9 M UDP-galactopyranose mutase
APPPKGNO_00858 1.8e-116 M Core-2/I-Branching enzyme
APPPKGNO_00859 8.5e-90 rfbP M Bacterial sugar transferase
APPPKGNO_00860 3.7e-126 brpA K Cell envelope-like function transcriptional attenuator common domain protein
APPPKGNO_00861 8.6e-110 ywqE 3.1.3.48 GM PHP domain protein
APPPKGNO_00862 1.2e-81 ywqD 2.7.10.1 D Capsular exopolysaccharide family
APPPKGNO_00863 3e-73 epsB M biosynthesis protein
APPPKGNO_00865 2.7e-114 cps2J S Polysaccharide biosynthesis protein
APPPKGNO_00866 1.2e-67 S Polysaccharide pyruvyl transferase
APPPKGNO_00868 4.5e-28 M family 8
APPPKGNO_00869 6.5e-59
APPPKGNO_00870 5.9e-37 M group 2 family protein
APPPKGNO_00871 1e-91 M Glycosyl transferase family 8
APPPKGNO_00872 5.9e-114 3.6.4.12 L UvrD/REP helicase N-terminal domain
APPPKGNO_00873 4.8e-144 L AAA ATPase domain
APPPKGNO_00874 4.9e-79 S response to antibiotic
APPPKGNO_00875 9.8e-27 S zinc-ribbon domain
APPPKGNO_00876 1.6e-117 nagZ 3.2.1.52 G Glycosyl hydrolase family 3 N terminal domain
APPPKGNO_00877 2.1e-130 rfbD 1.1.1.133, 5.1.3.13 M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
APPPKGNO_00878 5.6e-181 rfbB 4.2.1.46 M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
APPPKGNO_00879 4.2e-101 rfbC 5.1.3.13 M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
APPPKGNO_00880 1.9e-142 rfbA 2.7.7.24 H Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
APPPKGNO_00881 1.7e-62 S Glycosyltransferase like family 2
APPPKGNO_00882 2.2e-116 cps1D M Domain of unknown function (DUF4422)
APPPKGNO_00883 7.3e-38 S CAAX protease self-immunity
APPPKGNO_00884 1e-87 yvyE 3.4.13.9 S YigZ family
APPPKGNO_00885 3.3e-57 S Haloacid dehalogenase-like hydrolase
APPPKGNO_00886 3.4e-154 EGP Major facilitator Superfamily
APPPKGNO_00888 2.2e-66 ypgQ S Metal dependent phosphohydrolases with conserved 'HD' motif.
APPPKGNO_00889 1.2e-27 yraB K transcriptional regulator
APPPKGNO_00890 9.8e-90 S NADPH-dependent FMN reductase
APPPKGNO_00891 1.7e-100 thiD 2.5.1.3, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Phosphomethylpyrimidine kinase
APPPKGNO_00892 8.6e-56 S ECF transporter, substrate-specific component
APPPKGNO_00893 2.8e-95 znuB U ABC 3 transport family
APPPKGNO_00894 1e-98 fhuC P ABC transporter
APPPKGNO_00895 5.1e-103 psaA P Belongs to the bacterial solute-binding protein 9 family
APPPKGNO_00896 1.3e-40
APPPKGNO_00897 5e-51 I Alpha/beta hydrolase family
APPPKGNO_00898 1.8e-94 S Bacterial membrane protein, YfhO
APPPKGNO_00899 5.5e-53 XK27_01040 S Protein of unknown function (DUF1129)
APPPKGNO_00900 2.4e-190 ychF J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
APPPKGNO_00901 1.8e-24 yyzM S Bacterial protein of unknown function (DUF951)
APPPKGNO_00902 1.4e-108 spo0J K Belongs to the ParB family
APPPKGNO_00903 6.5e-118 soj D Sporulation initiation inhibitor
APPPKGNO_00904 3.7e-82 noc K Belongs to the ParB family
APPPKGNO_00905 1.1e-101 rsmG 2.1.1.170 J Specifically methylates the N7 position of a guanine in 16S rRNA
APPPKGNO_00906 4.1e-127 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
APPPKGNO_00907 2.7e-108 3.1.4.46 C phosphodiesterase
APPPKGNO_00908 0.0 pacL 3.6.3.8 P P-type ATPase
APPPKGNO_00909 7.9e-62 yvdD 3.2.2.10 S Possible lysine decarboxylase
APPPKGNO_00910 1.8e-72 thiJ 2.7.11.1, 3.5.1.124 S DJ-1/PfpI family
APPPKGNO_00912 2.3e-63 srtA 3.4.22.70 M sortase family
APPPKGNO_00913 0.0 addA 3.6.4.12 L ATP-dependent helicase nuclease subunit A
APPPKGNO_00914 0.0 rexB 3.1.21.3, 3.6.4.12 L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' - 3' nuclease activity
APPPKGNO_00915 3.7e-34
APPPKGNO_00916 1.8e-141 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APPPKGNO_00917 4e-157 proA 1.2.1.41 E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
APPPKGNO_00918 6.6e-97 proB 2.7.2.11 F Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
APPPKGNO_00919 4.7e-158 manA 5.3.1.8 G mannose-6-phosphate isomerase
APPPKGNO_00920 1.1e-39 ybjQ S Belongs to the UPF0145 family
APPPKGNO_00921 2.5e-08
APPPKGNO_00922 8e-96 V ABC transporter, ATP-binding protein
APPPKGNO_00923 1.1e-41 gntR1 K Transcriptional regulator, GntR family
APPPKGNO_00924 6.4e-186 mtlD 1.1.1.17 C mannitol-1-phosphate 5-dehydrogenase activity
APPPKGNO_00925 2.8e-65 mtlF 2.7.1.197 G catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
APPPKGNO_00926 4.2e-261 mtlA 2.7.1.197 G PTS system, Lactose/Cellobiose specific IIB subunit
APPPKGNO_00927 2.2e-107 terC P Integral membrane protein TerC family
APPPKGNO_00928 1.6e-38 K Transcriptional regulator
APPPKGNO_00929 5.7e-96 tcyA ET Belongs to the bacterial solute-binding protein 3 family
APPPKGNO_00930 4.1e-101 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
APPPKGNO_00931 4.5e-102 tcyB E ABC transporter
APPPKGNO_00932 3.2e-29 ponA V the current gene model (or a revised gene model) may contain a frame shift
APPPKGNO_00933 4.7e-188 nox S Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
APPPKGNO_00934 1.5e-301 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
APPPKGNO_00935 2e-209 mtlR K Mga helix-turn-helix domain
APPPKGNO_00936 7.5e-177 yjcE P Sodium proton antiporter
APPPKGNO_00937 8.4e-104 glpF U Belongs to the MIP aquaporin (TC 1.A.8) family
APPPKGNO_00938 4e-49 dhaM 2.7.1.121 S PTS system fructose IIA component
APPPKGNO_00939 9.5e-69 dhaL 2.7.1.121 S Dak2
APPPKGNO_00940 2e-151 dhaK 2.7.1.121, 2.7.1.28, 2.7.1.29, 4.6.1.15 G Dak1 domain
APPPKGNO_00941 9.3e-114 dhaK 2.7.1.121, 2.7.1.28, 2.7.1.29, 4.6.1.15 G Dak1 domain
APPPKGNO_00942 1.7e-61 K Bacterial regulatory proteins, tetR family
APPPKGNO_00943 3.2e-208 brnQ U Component of the transport system for branched-chain amino acids
APPPKGNO_00945 3.7e-111 endA F DNA RNA non-specific endonuclease
APPPKGNO_00946 4.1e-75 XK27_02070 S Nitroreductase family
APPPKGNO_00947 3.1e-193 cadA 3.6.3.3, 3.6.3.5 P P-type ATPase
APPPKGNO_00948 3.5e-33 nmtR K helix_turn_helix, Arsenical Resistance Operon Repressor
APPPKGNO_00949 5.2e-293 lai 4.2.1.53 S Myosin-crossreactive antigen
APPPKGNO_00950 7.2e-114 dak 2.7.1.74, 2.7.1.76 F deoxynucleoside kinase
APPPKGNO_00951 9.3e-59 2.4.2.6 F Nucleoside 2-deoxyribosyltransferase
APPPKGNO_00952 5.1e-77 azlC E branched-chain amino acid
APPPKGNO_00953 2e-31 azlD S Branched-chain amino acid transport protein (AzlD)
APPPKGNO_00954 1.5e-56 ohrR K helix_turn_helix multiple antibiotic resistance protein
APPPKGNO_00955 1.6e-55 jag S R3H domain protein
APPPKGNO_00956 1.2e-123 sip L Belongs to the 'phage' integrase family
APPPKGNO_00957 1.4e-24 K Cro/C1-type HTH DNA-binding domain
APPPKGNO_00958 2.5e-08 S Helix-turn-helix domain
APPPKGNO_00960 6.8e-39 K COG3617 Prophage antirepressor
APPPKGNO_00965 6.7e-15
APPPKGNO_00966 3.1e-43 L Bifunctional DNA primase/polymerase, N-terminal
APPPKGNO_00967 1e-76 S DNA primase
APPPKGNO_00969 1.1e-08
APPPKGNO_00972 6.9e-54 K Transcriptional regulator C-terminal region
APPPKGNO_00973 7.7e-44 thiT S Thiamine transporter protein (Thia_YuaJ)
APPPKGNO_00974 2.6e-285 pepO 3.4.24.71 O Peptidase family M13
APPPKGNO_00975 1.7e-111 dat 2.6.1.21 EH PFAM aminotransferase, class IV
APPPKGNO_00976 1.7e-09 yvaZ S Protein of unknown function (DUF1648)
APPPKGNO_00977 2.1e-69 pdxK 2.7.1.35 H Phosphomethylpyrimidine kinase
APPPKGNO_00978 3.9e-47 hmpT S ECF-type riboflavin transporter, S component
APPPKGNO_00979 5.1e-42 wecD K Acetyltransferase GNAT Family
APPPKGNO_00981 2.5e-254 XK27_06780 V ABC transporter permease
APPPKGNO_00982 6.4e-96 XK27_06785 V ABC transporter, ATP-binding protein
APPPKGNO_00984 7.5e-72 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
APPPKGNO_00985 6.9e-121 ytbE S reductase
APPPKGNO_00986 4.2e-43 ytcD K HxlR-like helix-turn-helix
APPPKGNO_00987 1.9e-101 ybbM S Uncharacterised protein family (UPF0014)
APPPKGNO_00988 2e-67 ybbL S ABC transporter
APPPKGNO_00989 8.1e-163 oxlT P Major Facilitator Superfamily
APPPKGNO_00990 6.2e-53 tpx 1.11.1.15 O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
APPPKGNO_00991 3.1e-47 S Short repeat of unknown function (DUF308)
APPPKGNO_00992 1.4e-30 tetR K Transcriptional regulator C-terminal region
APPPKGNO_00993 1.2e-150 yfeX P Peroxidase
APPPKGNO_00994 2.5e-16 S Protein of unknown function (DUF3021)
APPPKGNO_00995 4.5e-39 K LytTr DNA-binding domain
APPPKGNO_00996 7.6e-113 mmuM 1.5.1.20, 2.1.1.10 H homocysteine S-methyltransferase
APPPKGNO_00997 8.4e-209 mmuP E amino acid
APPPKGNO_00998 1.2e-15 psiE S Phosphate-starvation-inducible E
APPPKGNO_00999 3.7e-155 oppF P Belongs to the ABC transporter superfamily
APPPKGNO_01000 7.4e-181 oppD P Belongs to the ABC transporter superfamily
APPPKGNO_01001 4.4e-170 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
APPPKGNO_01002 7.9e-142 oppB P ABC-type dipeptide oligopeptide nickel transport systems, permease components
APPPKGNO_01003 1.1e-202 oppA E ABC transporter, substratebinding protein
APPPKGNO_01004 1.2e-218 yifK E Amino acid permease
APPPKGNO_01005 1.1e-85 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APPPKGNO_01006 5.1e-57 ybjI 3.1.3.102, 3.1.3.104, 3.1.3.23 S Sucrose-6F-phosphate phosphohydrolase
APPPKGNO_01007 6.5e-66 pgm3 G phosphoglycerate mutase family
APPPKGNO_01008 1.3e-252 ctpA 3.6.3.54 P P-type ATPase
APPPKGNO_01009 1.9e-21 silP 1.9.3.1, 3.6.3.54 S Cupredoxin-like domain
APPPKGNO_01010 6.8e-44 silP 1.9.3.1, 3.6.3.54 S Cupredoxin-like domain
APPPKGNO_01011 5.6e-150 glxK 2.7.1.165 G Belongs to the glycerate kinase type-1 family
APPPKGNO_01012 5.3e-134 glpQ 3.1.4.46 C Glycerophosphoryl diester phosphodiesterase family
APPPKGNO_01013 4.3e-80 metAA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to
APPPKGNO_01014 8.6e-141 cysK 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
APPPKGNO_01015 1.6e-201 oppA2 E Bacterial extracellular solute-binding proteins, family 5 Middle
APPPKGNO_01016 2.9e-117 pepL 3.4.11.5 E Releases the N-terminal proline from various substrates
APPPKGNO_01017 1.2e-197 1.3.5.4 C FMN_bind
APPPKGNO_01018 2.2e-56 3.1.3.48 K Transcriptional regulator
APPPKGNO_01019 3.8e-161 adhB 1.1.1.1, 1.1.1.14 E alcohol dehydrogenase
APPPKGNO_01020 4.5e-196 metY 2.5.1.49 E Catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol
APPPKGNO_01021 3.7e-74 metAA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to
APPPKGNO_01022 9.3e-129 yxjG 2.1.1.14 E Cobalamin-independent synthase, Catalytic domain
APPPKGNO_01023 1.6e-100 nfrA 1.5.1.38, 1.5.1.39 C nitroreductase
APPPKGNO_01024 2.8e-81 S Belongs to the UPF0246 family
APPPKGNO_01025 5.6e-10 S CAAX protease self-immunity
APPPKGNO_01026 3.5e-59 ykhA 3.1.2.20 I Thioesterase superfamily
APPPKGNO_01027 8.7e-157 trxB 1.8.1.9 C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
APPPKGNO_01029 7.4e-231 purA 6.3.4.4 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
APPPKGNO_01030 5.3e-64 C FMN binding
APPPKGNO_01031 1.3e-204 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
APPPKGNO_01032 1.7e-54 rplI J Binds to the 23S rRNA
APPPKGNO_01033 2.3e-263 yybT T signaling protein consisting of a modified GGDEF domain and a DHH domain
APPPKGNO_01034 3.6e-07
APPPKGNO_01035 8.8e-50 yugI 5.3.1.9 J general stress protein
APPPKGNO_01036 5.5e-96 trxB2 1.18.1.2, 1.19.1.1 C Ferredoxin--NADP reductase
APPPKGNO_01037 5.1e-92 dedA S SNARE associated Golgi protein
APPPKGNO_01038 7.8e-32 S Protein of unknown function (DUF1461)
APPPKGNO_01039 2.9e-113 nagD 2.7.1.25, 3.1.3.41 G Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
APPPKGNO_01040 1.9e-53 yutD S Protein of unknown function (DUF1027)
APPPKGNO_01041 3e-57 S Calcineurin-like phosphoesterase
APPPKGNO_01042 1.6e-183 cycA E Amino acid permease
APPPKGNO_01043 7.6e-98 ytxK 2.1.1.72 L N-6 DNA Methylase
APPPKGNO_01045 5.5e-11 S Putative Competence protein ComGF
APPPKGNO_01047 1.5e-13
APPPKGNO_01048 1.2e-27 comGC U competence protein ComGC
APPPKGNO_01049 5.7e-98 comGB NU type II secretion system
APPPKGNO_01050 4.7e-121 comGA NU Type II IV secretion system protein
APPPKGNO_01051 2.3e-101 rbsK 2.7.1.15 H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APPPKGNO_01052 1.5e-119 yebC K Transcriptional regulatory protein
APPPKGNO_01053 3.7e-42 S VanZ like family
APPPKGNO_01054 1.3e-158 ccpA K catabolite control protein A
APPPKGNO_01055 1.3e-172 pepQ 3.4.13.9 E Creatinase/Prolidase N-terminal domain
APPPKGNO_01056 1.5e-13
APPPKGNO_01059 1.7e-74 rnhA 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APPPKGNO_01060 2.1e-34 K helix_turn_helix, Arsenical Resistance Operon Repressor
APPPKGNO_01061 2.3e-65 hly S protein, hemolysin III
APPPKGNO_01062 2.5e-41 M1-874 K Domain of unknown function (DUF1836)
APPPKGNO_01063 1.8e-82 S membrane
APPPKGNO_01064 9.2e-79 S VIT family
APPPKGNO_01065 6.8e-148 fba 4.1.2.13, 4.1.2.29 G Fructose-1,6-bisphosphate aldolase, class II
APPPKGNO_01066 2.7e-56 P Plays a role in the regulation of phosphate uptake
APPPKGNO_01067 4.7e-116 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
APPPKGNO_01068 4.5e-114 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
APPPKGNO_01069 5.1e-122 pstA P Phosphate transport system permease protein PstA
APPPKGNO_01070 4.1e-119 pstC P probably responsible for the translocation of the substrate across the membrane
APPPKGNO_01071 6.4e-98 pstS P Phosphate
APPPKGNO_01072 1e-41 yjbH Q Thioredoxin
APPPKGNO_01073 1.9e-232 pepF E oligoendopeptidase F
APPPKGNO_01074 1.1e-68 coiA 3.6.4.12 S Competence protein
APPPKGNO_01075 1.2e-47 mecA NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
APPPKGNO_01076 8.2e-219 pckA 4.1.1.49 H Phosphoenolpyruvate carboxykinase
APPPKGNO_01082 5.1e-08
APPPKGNO_01085 3.5e-23 L PLD-like domain
APPPKGNO_01086 6.5e-12 L PLD-like domain
APPPKGNO_01088 6.1e-08 yokH G regulation of fungal-type cell wall biogenesis
APPPKGNO_01089 9.4e-109 L Initiator Replication protein
APPPKGNO_01090 1.9e-37 S Replication initiator protein A (RepA) N-terminus
APPPKGNO_01091 8.5e-141 ascB 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
APPPKGNO_01092 3.2e-84 G phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1
APPPKGNO_01093 1.4e-12 bglG K antiterminator
APPPKGNO_01094 2.9e-124 D CobQ CobB MinD ParA nucleotide binding domain protein
APPPKGNO_01096 1.1e-35
APPPKGNO_01097 0.0 pepN 3.4.11.2 E aminopeptidase
APPPKGNO_01098 1.8e-43 2.7.13.3 T protein histidine kinase activity
APPPKGNO_01099 1.6e-22 agrA KT Response regulator of the LytR AlgR family
APPPKGNO_01101 1.3e-16 M domain protein
APPPKGNO_01106 3.6e-125 yvgN C Aldo keto reductase
APPPKGNO_01107 1.7e-122 yvgN C Aldo keto reductase
APPPKGNO_01108 2.2e-70 K DeoR C terminal sensor domain
APPPKGNO_01109 1.1e-46 pts36A 2.7.1.200, 2.7.1.202 G Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
APPPKGNO_01110 3.4e-41 sgcB 2.7.1.200 G PTS system, Lactose/Cellobiose specific IIB subunit
APPPKGNO_01111 1.2e-216 pts36C G PTS system sugar-specific permease component
APPPKGNO_01113 2.3e-104 4.1.2.17 G Class II Aldolase and Adducin N-terminal domain
APPPKGNO_01115 6.2e-29 S COG NOG19168 non supervised orthologous group
APPPKGNO_01116 1.1e-189 XK27_11280 S Psort location CytoplasmicMembrane, score
APPPKGNO_01117 2.7e-14 L Plasmid pRiA4b ORF-3-like protein
APPPKGNO_01118 1.5e-105 L Belongs to the 'phage' integrase family
APPPKGNO_01119 5.7e-23 3.1.21.3 V Type I restriction modification DNA specificity domain
APPPKGNO_01120 8.6e-60 hsdM 2.1.1.72 V type I restriction-modification system
APPPKGNO_01122 3.2e-55 sthIM 2.1.1.72 L DNA methylase
APPPKGNO_01123 6.3e-109 sthIM 2.1.1.72 L Adenine specific DNA methylase Mod
APPPKGNO_01124 3.5e-54 sthIM 2.1.1.72 L DNA methylase
APPPKGNO_01125 4.6e-194 sthIM 2.1.1.72 L Adenine specific DNA methylase Mod
APPPKGNO_01126 8.5e-56 sthIM 2.1.1.72 L DNA methylase
APPPKGNO_01127 3.1e-116 sthIM 2.1.1.72 L Adenine specific DNA methylase Mod
APPPKGNO_01128 4e-260 res_1 3.1.21.5 L Type III restriction enzyme, res subunit
APPPKGNO_01129 4.6e-16
APPPKGNO_01130 4.9e-24
APPPKGNO_01131 3.4e-48 L HNH endonuclease
APPPKGNO_01134 3.6e-167 potE2 E amino acid
APPPKGNO_01135 4.8e-71 ald 1.4.1.1 C Belongs to the AlaDH PNT family
APPPKGNO_01136 2.3e-69 ald 1.4.1.1 C Belongs to the AlaDH PNT family
APPPKGNO_01137 7.2e-117 queH 1.17.99.6, 3.1.26.4 C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APPPKGNO_01138 1.9e-57 racA K Domain of unknown function (DUF1836)
APPPKGNO_01139 3.1e-81 yitS S EDD domain protein, DegV family
APPPKGNO_01140 1.7e-46 yjaB_1 K Acetyltransferase (GNAT) domain
APPPKGNO_01143 1e-36 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
APPPKGNO_01144 0.0 O Belongs to the peptidase S8 family
APPPKGNO_01145 4.1e-53 1.14.12.17 C Oxidoreductase NAD-binding domain
APPPKGNO_01146 2.5e-58 tlpA2 L Transposase IS200 like
APPPKGNO_01147 1.1e-157 L transposase, IS605 OrfB family
APPPKGNO_01148 4.6e-84 dps P Ferritin-like domain
APPPKGNO_01149 1.1e-124 4.1.99.16, 4.2.3.22, 4.2.3.75 K helix_turn_helix, cAMP Regulatory protein
APPPKGNO_01150 9.6e-44 L hmm pf00665
APPPKGNO_01151 5e-18 tnp
APPPKGNO_01152 8.7e-31 tnp L Transposase IS66 family
APPPKGNO_01153 1.7e-32 P Heavy-metal-associated domain
APPPKGNO_01154 0.0 cadA 3.6.3.3, 3.6.3.5 P E1-E2 ATPase
APPPKGNO_01155 1.3e-20 L PFAM transposase IS3 IS911 family protein
APPPKGNO_01156 1.4e-41 L Integrase core domain
APPPKGNO_01157 2.4e-35 L Integrase core domain
APPPKGNO_01158 1.3e-128 EGP Major Facilitator Superfamily
APPPKGNO_01159 1.4e-98 EGP Major Facilitator Superfamily
APPPKGNO_01160 7.5e-73 K Transcriptional regulator, LysR family
APPPKGNO_01161 4.7e-138 G Xylose isomerase-like TIM barrel
APPPKGNO_01162 4.6e-117 IQ Enoyl-(Acyl carrier protein) reductase
APPPKGNO_01163 4e-216 1.3.5.4 C FAD binding domain
APPPKGNO_01164 6.5e-138 aroE 1.1.1.25, 1.1.1.282, 1.3.5.4 E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APPPKGNO_01165 1e-70 aroD 1.1.1.25, 4.2.1.10 E Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
APPPKGNO_01166 4.2e-142 xerS L Phage integrase family
APPPKGNO_01170 1.1e-20 cbh 3.5.1.24 M Linear amide C-N hydrolases, choloylglycine hydrolase family
APPPKGNO_01171 2.5e-82 cbh 3.5.1.24 M Linear amide C-N hydrolases, choloylglycine hydrolase family
APPPKGNO_01172 8.2e-13 ptp3 3.1.3.48 T Tyrosine phosphatase family
APPPKGNO_01173 8.7e-39 ptp3 3.1.3.48 T Tyrosine phosphatase family
APPPKGNO_01174 2.4e-75 desR K helix_turn_helix, Lux Regulon
APPPKGNO_01175 8.4e-58 salK 2.7.13.3 T Histidine kinase
APPPKGNO_01176 3.2e-53 yvfS V ABC-2 type transporter
APPPKGNO_01177 3.4e-78 yvfR V ABC transporter
APPPKGNO_01178 1.2e-99 rpiA 2.7.1.12, 5.3.1.6 G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
APPPKGNO_01179 1.9e-78 rpe 5.1.3.1 G Belongs to the ribulose-phosphate 3-epimerase family
APPPKGNO_01180 2.7e-30
APPPKGNO_01181 3.7e-16
APPPKGNO_01182 3e-111 rssA S Phospholipase, patatin family
APPPKGNO_01183 1.5e-136 pflA 1.97.1.4 C Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APPPKGNO_01184 0.0 pflB 2.3.1.54 C Pyruvate formate lyase-like
APPPKGNO_01185 5.5e-45 S VIT family
APPPKGNO_01186 4.2e-240 sufB O assembly protein SufB
APPPKGNO_01187 4.9e-41 nifU C SUF system FeS assembly protein, NifU family
APPPKGNO_01188 3.7e-147 sufS 2.8.1.7, 4.4.1.16 E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APPPKGNO_01189 4.6e-145 sufD O FeS assembly protein SufD
APPPKGNO_01190 1.1e-115 sufC O FeS assembly ATPase SufC
APPPKGNO_01191 1.7e-224 E ABC transporter, substratebinding protein
APPPKGNO_01192 2.5e-255 V Type II restriction enzyme, methylase subunits
APPPKGNO_01193 5.6e-136 pfoS S Phosphotransferase system, EIIC
APPPKGNO_01194 5.5e-117 ldhA 1.1.1.28 CH D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
APPPKGNO_01195 6.3e-64 tal 2.2.1.2 H Transaldolase/Fructose-6-phosphate aldolase
APPPKGNO_01196 2.4e-36 srlB 2.7.1.198 G PTS system glucitol/sorbitol-specific IIA component
APPPKGNO_01197 1.1e-136 srlE 2.7.1.198 G Sorbitol phosphotransferase enzyme II N-terminus
APPPKGNO_01198 4.8e-83 srlA G PTS system enzyme II sorbitol-specific factor
APPPKGNO_01199 4.5e-43 gutM K Glucitol operon activator protein (GutM)
APPPKGNO_01200 1.3e-103 srlM 2.7.1.194, 2.7.1.200, 2.7.1.202 GKT Mga helix-turn-helix domain
APPPKGNO_01201 5.2e-110 IQ NAD dependent epimerase/dehydratase family
APPPKGNO_01202 1.8e-162 ytbD EGP Major facilitator Superfamily
APPPKGNO_01203 3e-98 fabK 1.3.1.9 S Nitronate monooxygenase
APPPKGNO_01204 0.0 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
APPPKGNO_01206 1.1e-265 fbp 3.1.3.11 G phosphatase activity
APPPKGNO_01207 1.4e-70 xerD L Phage integrase, N-terminal SAM-like domain
APPPKGNO_01210 2e-86 mesE M Transport protein ComB
APPPKGNO_01211 4e-282 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
APPPKGNO_01214 7.3e-56 K LytTr DNA-binding domain
APPPKGNO_01215 1.8e-51 2.7.13.3 T GHKL domain
APPPKGNO_01221 9.2e-16
APPPKGNO_01223 7.2e-08
APPPKGNO_01224 6.6e-19
APPPKGNO_01225 5.9e-39 blpT
APPPKGNO_01226 3e-87 S Haloacid dehalogenase-like hydrolase
APPPKGNO_01227 1.8e-14
APPPKGNO_01229 1.8e-28 S Phage gp6-like head-tail connector protein
APPPKGNO_01230 3.1e-98
APPPKGNO_01231 4e-08 S Domain of unknown function (DUF4355)
APPPKGNO_01234 9.5e-17 S head morphogenesis protein, SPP1 gp7 family
APPPKGNO_01235 5.9e-187 mtnE 2.6.1.83 E Aminotransferase
APPPKGNO_01236 1.3e-81 mtnU 3.5.1.3 S Carbon-nitrogen hydrolase
APPPKGNO_01237 1.3e-66 S Protein of unknown function (DUF1440)
APPPKGNO_01238 7.7e-41 S Iron-sulfur cluster assembly protein
APPPKGNO_01239 3.3e-113 sdaAA 4.3.1.17 E L-serine dehydratase, iron-sulfur-dependent, alpha subunit
APPPKGNO_01240 5.9e-75 sdaAB 4.3.1.17 E Serine dehydratase beta chain
APPPKGNO_01241 5.1e-207 nanT E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APPPKGNO_01242 5.6e-153 napA P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
APPPKGNO_01243 4e-64 G Xylose isomerase domain protein TIM barrel
APPPKGNO_01244 1.1e-89 nanK GK ROK family
APPPKGNO_01245 1.3e-127 nanA 4.1.3.3, 4.3.3.7 EM Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate
APPPKGNO_01246 2.5e-92 nanE 5.1.3.9 G Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
APPPKGNO_01247 4.3e-75 K Helix-turn-helix domain, rpiR family
APPPKGNO_01248 1.5e-56 yphA GM NAD dependent epimerase/dehydratase family
APPPKGNO_01249 6.9e-217 yjeM E Amino Acid
APPPKGNO_01251 1.6e-31 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APPPKGNO_01252 3.4e-232 tetP J elongation factor G
APPPKGNO_01254 1.3e-10 tcdC
APPPKGNO_01256 7.3e-102 L PLD-like domain
APPPKGNO_01257 1.6e-137 L Belongs to the 'phage' integrase family
APPPKGNO_01258 1.1e-216 ltrA_1 2.7.7.49 L PFAM RNA-directed DNA polymerase (Reverse transcriptase)
APPPKGNO_01259 7.2e-149 mepA V MATE efflux family protein
APPPKGNO_01260 5.6e-150 lsa S ABC transporter
APPPKGNO_01261 4e-83 ppiB 5.2.1.8 G PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APPPKGNO_01262 6.8e-109 puuD S peptidase C26
APPPKGNO_01263 9.8e-202 gshF 6.3.2.2 H Belongs to the glutamate--cysteine ligase type 1 family
APPPKGNO_01264 1.1e-25
APPPKGNO_01265 0.0 clpL O C-terminal, D2-small domain, of ClpB protein
APPPKGNO_01266 2.9e-60 uspA T Universal stress protein family
APPPKGNO_01268 4.7e-210 glnP P ABC transporter
APPPKGNO_01269 1.9e-168 ilvE 2.6.1.42 E Branched-chain amino acid aminotransferase
APPPKGNO_01270 3e-95 L Transposase IS66 family
APPPKGNO_01271 6.4e-44 XK27_01125 L PFAM IS66 Orf2 family protein
APPPKGNO_01273 8e-37 L Integrase core domain
APPPKGNO_01274 3.9e-147 scrR K helix_turn _helix lactose operon repressor
APPPKGNO_01275 5.9e-216 scrB 3.2.1.26 GH32 G invertase
APPPKGNO_01276 1.4e-281 scrA 2.7.1.211, 5.3.1.1 G phosphotransferase system
APPPKGNO_01277 2.6e-183 nplT 3.2.1.133, 3.2.1.135, 3.2.1.54 GH13 G Belongs to the glycosyl hydrolase 13 family
APPPKGNO_01278 1.2e-114 ntpJ P Potassium uptake protein
APPPKGNO_01279 4.8e-58 ktrA P TrkA-N domain
APPPKGNO_01280 5.7e-54 XK27_08875 O PFAM peptidase M10A and M12B, matrixin and adamalysin
APPPKGNO_01281 1.3e-36 M Glycosyltransferase group 2 family protein
APPPKGNO_01282 1.4e-19
APPPKGNO_01283 1.8e-94 S Predicted membrane protein (DUF2207)
APPPKGNO_01284 2.1e-54 bioY S BioY family
APPPKGNO_01285 2.2e-94 dacA 3.4.16.4 M Belongs to the peptidase S11 family
APPPKGNO_01286 7.6e-74 glcR K DeoR C terminal sensor domain
APPPKGNO_01287 2.2e-60 yceE S haloacid dehalogenase-like hydrolase
APPPKGNO_01288 1.1e-41 S CAAX protease self-immunity
APPPKGNO_01289 9.1e-34 S Domain of unknown function (DUF4811)
APPPKGNO_01290 2.1e-197 lmrB EGP Major facilitator Superfamily
APPPKGNO_01291 1.9e-32 merR K MerR HTH family regulatory protein
APPPKGNO_01292 1.8e-39 yaeR E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
APPPKGNO_01293 1.2e-70 S Protein of unknown function (DUF554)
APPPKGNO_01294 2.8e-121 G Bacterial extracellular solute-binding protein
APPPKGNO_01295 3.9e-79 baeR K Bacterial regulatory proteins, luxR family
APPPKGNO_01296 5.1e-99 baeS T Histidine kinase
APPPKGNO_01297 1.1e-80 rbsB G sugar-binding domain protein
APPPKGNO_01298 9e-152 manL 2.7.1.191 G PTS system sorbose subfamily IIB component
APPPKGNO_01299 6.4e-116 manY G PTS system sorbose-specific iic component
APPPKGNO_01300 6.1e-147 manN G system, mannose fructose sorbose family IID component
APPPKGNO_01301 2.4e-52 manO S Domain of unknown function (DUF956)
APPPKGNO_01302 9.5e-16 S Protein of unknown function (DUF805)
APPPKGNO_01303 2.1e-70 mltD CBM50 M NlpC P60 family protein
APPPKGNO_01304 4.7e-130 serC 2.6.1.52 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
APPPKGNO_01305 4.9e-165 serA 1.1.1.399, 1.1.1.95 EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APPPKGNO_01306 2.4e-75 ung2 3.2.2.27 L Uracil-DNA glycosylase
APPPKGNO_01307 3.5e-48 traP 1.14.99.57, 6.2.1.3 S enzyme involved in biosynthesis of extracellular polysaccharides
APPPKGNO_01308 0.0 cas9 L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
APPPKGNO_01309 3.9e-106 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
APPPKGNO_01310 6.5e-37 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
APPPKGNO_01311 2e-46 S CRISPR-associated protein (Cas_Csn2)
APPPKGNO_01315 8.1e-38 K transcriptional regulator PadR family
APPPKGNO_01316 7.1e-19 XK27_06920 S Protein of unknown function (DUF1700)
APPPKGNO_01317 3.1e-16 S Putative adhesin
APPPKGNO_01318 2.2e-16 pspC KT PspC domain
APPPKGNO_01320 3e-13 S Enterocin A Immunity
APPPKGNO_01321 5.2e-236 glpK 2.7.1.30 F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
APPPKGNO_01322 5.7e-261 glpD 1.1.3.21, 1.1.5.3 C C-terminal domain of alpha-glycerophosphate oxidase
APPPKGNO_01323 7.4e-100 glpF U Belongs to the MIP aquaporin (TC 1.A.8) family
APPPKGNO_01324 8.2e-167 potA 3.6.3.30, 3.6.3.31 P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
APPPKGNO_01325 1.5e-120 potB P ABC transporter permease
APPPKGNO_01326 1.7e-103 potC U Binding-protein-dependent transport system inner membrane component
APPPKGNO_01327 1.3e-159 potD P ABC transporter
APPPKGNO_01328 7.8e-132 ABC-SBP S ABC transporter
APPPKGNO_01329 4.3e-113 XK27_08840 U Belongs to the binding-protein-dependent transport system permease family
APPPKGNO_01330 1.4e-107 XK27_08845 S ABC transporter, ATP-binding protein
APPPKGNO_01331 1.5e-67 M ErfK YbiS YcfS YnhG
APPPKGNO_01332 4.1e-54 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
APPPKGNO_01333 1.9e-224 mnmE S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
APPPKGNO_01334 0.0 gidA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
APPPKGNO_01335 1.2e-102 pgm3 G phosphoglycerate mutase
APPPKGNO_01336 8.5e-58 S CAAX protease self-immunity
APPPKGNO_01337 2e-45 C Flavodoxin
APPPKGNO_01338 1.2e-57 yphH S Cupin domain
APPPKGNO_01339 1e-45 yphJ 4.1.1.44 S decarboxylase
APPPKGNO_01340 1.2e-144 2.1.1.14 E methionine synthase, vitamin-B12 independent
APPPKGNO_01341 5.1e-108 metQ1 P Belongs to the nlpA lipoprotein family
APPPKGNO_01342 2e-149 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APPPKGNO_01343 1.3e-69 metI P ABC transporter permease
APPPKGNO_01344 8.8e-135 argE 3.5.1.18 E succinyl-diaminopimelate desuccinylase
APPPKGNO_01345 3e-84 drgA C nitroreductase
APPPKGNO_01346 1.1e-83 adc 4.1.1.4 Q Acetoacetate decarboxylase (ADC)
APPPKGNO_01347 1.7e-106 fadB4 1.1.1.157 I 3-hydroxyacyl-CoA dehydrogenase
APPPKGNO_01348 5.3e-171 npr 1.11.1.1 S Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
APPPKGNO_01349 1.7e-264 yaaO 4.1.1.17, 4.1.1.19 E Orn/Lys/Arg decarboxylase, C-terminal domain
APPPKGNO_01351 6.2e-151 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APPPKGNO_01352 2.4e-31 metI U ABC transporter permease
APPPKGNO_01353 1.5e-128 metQ M Belongs to the nlpA lipoprotein family
APPPKGNO_01354 6.5e-59 S Protein of unknown function (DUF4256)
APPPKGNO_01357 4.7e-178 pdhA 1.2.4.1, 1.2.4.4 C Dehydrogenase E1 component
APPPKGNO_01358 2.8e-166 pdhB 1.2.4.1 C Transketolase, C-terminal domain protein
APPPKGNO_01359 1.5e-180 pdhC 2.3.1.12 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
APPPKGNO_01360 4e-230 lpdA 1.8.1.4 C Dehydrogenase
APPPKGNO_01361 7.3e-149 lplA 6.3.1.20 H Lipoate-protein ligase
APPPKGNO_01362 9.2e-56 S Protein of unknown function (DUF975)
APPPKGNO_01363 2.2e-77 E GDSL-like Lipase/Acylhydrolase family
APPPKGNO_01364 6.1e-39
APPPKGNO_01365 4.1e-27 gcvR T Belongs to the UPF0237 family
APPPKGNO_01366 2.1e-220 XK27_08635 S UPF0210 protein
APPPKGNO_01367 4.5e-87 fruR K DeoR C terminal sensor domain
APPPKGNO_01368 4.1e-151 pfkB 2.7.1.11, 2.7.1.56 H Belongs to the carbohydrate kinase PfkB family. LacC subfamily
APPPKGNO_01369 5.1e-268 fruA 2.7.1.202 GT Phosphotransferase System
APPPKGNO_01370 1.2e-49 cps3F
APPPKGNO_01371 2.7e-83 S Membrane
APPPKGNO_01372 1.8e-254 E Amino acid permease
APPPKGNO_01373 5e-225 cadA P P-type ATPase
APPPKGNO_01374 6.4e-114 degV S EDD domain protein, DegV family
APPPKGNO_01375 1.9e-148 yfdH 2.4.2.53 GT2 M Glycosyltransferase, group 2 family protein
APPPKGNO_01376 5.6e-57 yfeJ 6.3.5.2 F glutamine amidotransferase
APPPKGNO_01377 1.9e-27 ydiI Q Thioesterase superfamily
APPPKGNO_01378 1.5e-144 menB 4.1.3.36 H Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
APPPKGNO_01379 5.6e-139 menE 6.2.1.26 H Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily
APPPKGNO_01380 5.6e-82 S L,D-transpeptidase catalytic domain
APPPKGNO_01381 4.4e-165 EGP Major facilitator Superfamily
APPPKGNO_01382 1.1e-21 K helix_turn_helix multiple antibiotic resistance protein
APPPKGNO_01383 6e-226 pipD E Dipeptidase
APPPKGNO_01384 7e-126 brpA K Cell envelope-like function transcriptional attenuator common domain protein
APPPKGNO_01385 2.6e-32 ywjH S Protein of unknown function (DUF1634)
APPPKGNO_01386 2.2e-119 yxaA S membrane transporter protein
APPPKGNO_01387 7.6e-83 lysR5 K LysR substrate binding domain
APPPKGNO_01388 3.2e-57 lssY 3.6.1.27 I phosphatidate phosphatase activity
APPPKGNO_01389 9.2e-14 2.3.1.128 J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APPPKGNO_01390 8.6e-272 alsS 2.2.1.6 EH Belongs to the TPP enzyme family
APPPKGNO_01391 2.3e-69 budA 4.1.1.5 Q Alpha-acetolactate decarboxylase
APPPKGNO_01392 3.6e-242 lysP E amino acid
APPPKGNO_01393 2.1e-190 serS 6.1.1.11 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
APPPKGNO_01402 2.2e-131 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
APPPKGNO_01403 2.1e-185 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
APPPKGNO_01404 6.3e-159 carA 6.3.5.5 F Carbamoyl-phosphate synthetase glutamine chain
APPPKGNO_01405 0.0 carB 6.3.5.5 F Carbamoyl-phosphate synthase
APPPKGNO_01406 1.1e-119 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
APPPKGNO_01408 1.6e-55 ctsR K Belongs to the CtsR family
APPPKGNO_01409 0.0 clpC O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
APPPKGNO_01410 0.0 rpoB 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APPPKGNO_01411 0.0 rpoC 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APPPKGNO_01412 3.3e-23 pilD 3.4.23.43 NOU aspartic-type endopeptidase activity
APPPKGNO_01413 6.1e-70 rpsL J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
APPPKGNO_01414 1.3e-81 rpsG J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
APPPKGNO_01415 0.0 fusA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APPPKGNO_01416 1.3e-91 cobB K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form
APPPKGNO_01417 5.2e-90 patB 4.4.1.8 E Aminotransferase, class I
APPPKGNO_01418 2.5e-113 K response regulator
APPPKGNO_01419 3.3e-142 hpk31 2.7.13.3 T Histidine kinase
APPPKGNO_01420 1.5e-91 lacX 5.1.3.3 G Aldose 1-epimerase
APPPKGNO_01421 3.9e-146 G Transporter, major facilitator family protein
APPPKGNO_01422 5.3e-224 dxs 2.2.1.7 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
APPPKGNO_01423 1.1e-244 yhcA V ABC transporter, ATP-binding protein
APPPKGNO_01424 3.4e-35 K Bacterial regulatory proteins, tetR family
APPPKGNO_01425 7.6e-223 lmrA V ABC transporter, ATP-binding protein
APPPKGNO_01426 1.8e-254 yfiC V ABC transporter
APPPKGNO_01428 3.2e-45 yjcF K protein acetylation
APPPKGNO_01429 3.5e-26 S Sel1-like repeats.
APPPKGNO_01430 5.4e-55 L phosphatase homologous to the C-terminal domain of histone macroH2A1
APPPKGNO_01431 3.3e-71 lemA S LemA family
APPPKGNO_01432 1.3e-114 htpX O Belongs to the peptidase M48B family
APPPKGNO_01434 2e-271 helD 3.6.4.12 L DNA helicase
APPPKGNO_01435 4.1e-73 P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
APPPKGNO_01436 1.3e-32 P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
APPPKGNO_01437 6.7e-171 trpS 6.1.1.2 J Belongs to the class-I aminoacyl-tRNA synthetase family
APPPKGNO_01438 1.6e-102 ppx 3.6.1.11, 3.6.1.40 FP exopolyphosphatase
APPPKGNO_01439 4.2e-82 ybhF_2 V AAA domain, putative AbiEii toxin, Type IV TA system
APPPKGNO_01440 5.9e-104 ybhR V ABC transporter
APPPKGNO_01441 7.9e-32 K Bacterial regulatory proteins, tetR family
APPPKGNO_01442 7.2e-43 VPA1512 ET Bacterial extracellular solute-binding proteins, family 3
APPPKGNO_01443 3.3e-151 mvaA 1.1.1.34, 1.1.1.88, 2.3.1.9 C Belongs to the HMG-CoA reductase family
APPPKGNO_01444 3.9e-128
APPPKGNO_01445 0.0 metG 6.1.1.10, 6.1.1.20 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APPPKGNO_01446 7.8e-103 tatD L hydrolase, TatD family
APPPKGNO_01447 3.4e-87 rnmV 3.1.26.8 J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
APPPKGNO_01448 1.4e-132 ksgA 2.1.1.182 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
APPPKGNO_01449 2.7e-22 veg S Biofilm formation stimulator VEG
APPPKGNO_01450 3.7e-90 S Alpha/beta hydrolase of unknown function (DUF915)
APPPKGNO_01451 5.5e-134 arcT 2.6.1.1 E Cys/Met metabolism PLP-dependent enzyme
APPPKGNO_01452 8.2e-47 argR K Regulates arginine biosynthesis genes
APPPKGNO_01453 4.8e-117 ispE 2.1.1.182, 2.7.1.148 F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
APPPKGNO_01454 3.5e-156 amtB P ammonium transporter
APPPKGNO_01456 1.7e-201 argH 4.3.2.1 E argininosuccinate lyase
APPPKGNO_01457 6.5e-197 argG 6.3.4.5 E Belongs to the argininosuccinate synthase family. Type 1 subfamily
APPPKGNO_01458 1.5e-150 patA 2.6.1.1, 2.6.1.57 E Aminotransferase
APPPKGNO_01459 9e-128 ldhD 1.1.1.28 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APPPKGNO_01460 4.4e-101 pfoS S Phosphotransferase system, EIIC
APPPKGNO_01461 3.9e-185 asd 1.2.1.11, 1.2.1.12 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APPPKGNO_01462 6.6e-53 adhR K helix_turn_helix, mercury resistance
APPPKGNO_01463 5.2e-137 purR 2.4.2.7 F pur operon repressor
APPPKGNO_01464 1.9e-47 EGP Transmembrane secretion effector
APPPKGNO_01465 1.1e-192 glmU 2.3.1.157, 2.7.7.23 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
APPPKGNO_01466 2.3e-168 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APPPKGNO_01467 3.1e-20 rimL 1.1.1.25 J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APPPKGNO_01468 3.1e-113 dkg S reductase
APPPKGNO_01469 1.7e-24
APPPKGNO_01470 6.7e-78 2.4.2.3 F Phosphorylase superfamily
APPPKGNO_01471 1.4e-290 ybiT S ABC transporter, ATP-binding protein
APPPKGNO_01472 2.1e-18 ytkL S Beta-lactamase superfamily domain
APPPKGNO_01473 1.2e-34 ytkL S Belongs to the UPF0173 family
APPPKGNO_01474 4.5e-100 birA 6.3.4.15 H Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
APPPKGNO_01475 2.1e-125 S overlaps another CDS with the same product name
APPPKGNO_01476 2.2e-86 S overlaps another CDS with the same product name
APPPKGNO_01478 4.6e-57 spoVK O ATPase family associated with various cellular activities (AAA)
APPPKGNO_01479 2.3e-22
APPPKGNO_01480 2.7e-38 L COGs COG0507 ATP-dependent exoDNAse (exonuclease V) alpha subunit - helicase superfamily I member
APPPKGNO_01482 1.3e-63
APPPKGNO_01483 8.2e-216 L Probable transposase
APPPKGNO_01484 6e-60 ydcZ S Putative inner membrane exporter, YdcZ
APPPKGNO_01485 6.4e-87 S hydrolase
APPPKGNO_01486 2.5e-205 ywfO S HD domain protein
APPPKGNO_01487 9.8e-86 yfeJ 6.3.5.2 F glutamine amidotransferase
APPPKGNO_01488 1.8e-32 ywiB S Domain of unknown function (DUF1934)
APPPKGNO_01489 1e-41 rpoE K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
APPPKGNO_01490 1.2e-288 pyrG 6.3.4.2 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
APPPKGNO_01493 1e-200 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APPPKGNO_01494 1.2e-188 rho K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
APPPKGNO_01495 3.6e-41 rpmE2 J Ribosomal protein L31
APPPKGNO_01496 2.8e-61
APPPKGNO_01497 7.8e-255 dinG 3.1.12.1, 3.6.4.12 KL DEAD_2
APPPKGNO_01499 4.7e-79 S Cell surface protein
APPPKGNO_01501 1.6e-180 pbuG S permease
APPPKGNO_01502 8.4e-65 S Uncharacterized protein conserved in bacteria (DUF2263)
APPPKGNO_01503 1.8e-179 murF 6.3.2.10 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
APPPKGNO_01504 3.4e-208 cshA 3.6.4.13 F DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
APPPKGNO_01505 1.6e-30 acpS 2.7.6.3, 2.7.8.7, 5.1.1.1 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
APPPKGNO_01506 4.8e-146 alr 5.1.1.1 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APPPKGNO_01507 5.4e-13
APPPKGNO_01508 3.4e-48 ndoA L Toxic component of a toxin-antitoxin (TA) module
APPPKGNO_01509 2.5e-91 yunF F Protein of unknown function DUF72
APPPKGNO_01510 2.3e-156 nrnB S DHHA1 domain
APPPKGNO_01511 3.7e-43 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins
APPPKGNO_01512 2.2e-59
APPPKGNO_01513 6e-49 ytlR 2.7.1.91 I Diacylglycerol kinase catalytic domain (presumed)
APPPKGNO_01514 5.4e-23 S Cytochrome B5
APPPKGNO_01515 1.1e-19 sigH K DNA-templated transcription, initiation
APPPKGNO_01516 2.9e-68 recX 2.4.1.337 GT4 S Regulatory protein RecX
APPPKGNO_01517 3.2e-192 rumA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APPPKGNO_01518 2.6e-97 ygaC J Belongs to the UPF0374 family
APPPKGNO_01519 6.9e-92 yueF S AI-2E family transporter
APPPKGNO_01520 1.9e-157 gpsA 1.1.1.94 I Glycerol-3-phosphate dehydrogenase
APPPKGNO_01521 1.4e-108 3.6.3.38, 3.6.3.40 GM Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system
APPPKGNO_01522 4e-279 prfC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
APPPKGNO_01523 6.3e-36
APPPKGNO_01524 0.0 lacL 3.2.1.23 G -beta-galactosidase
APPPKGNO_01525 1.2e-288 lacS G Transporter
APPPKGNO_01526 5.9e-111 galR K Transcriptional regulator
APPPKGNO_01527 2.6e-179 galK 2.7.1.6 F Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
APPPKGNO_01528 2.3e-163 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
APPPKGNO_01529 1.2e-200 galT 2.7.7.12 G UDP-glucose--hexose-1-phosphate uridylyltransferase
APPPKGNO_01530 0.0 rafA 3.2.1.22 G alpha-galactosidase
APPPKGNO_01531 5e-105 manA 1.14.13.81, 5.3.1.8, 5.4.2.8 G MucBP domain
APPPKGNO_01532 3e-23 XK27_09445 S Domain of unknown function (DUF1827)
APPPKGNO_01533 0.0 clpE O Belongs to the ClpA ClpB family
APPPKGNO_01534 1.5e-15
APPPKGNO_01535 9.7e-37 ptsH G phosphocarrier protein HPR
APPPKGNO_01536 2.4e-285 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APPPKGNO_01537 3.9e-162 mgs 2.4.1.337 GT4 M Glycosyltransferase, group 1 family protein
APPPKGNO_01538 1.2e-127 cpoA GT4 M Glycosyltransferase, group 1 family protein
APPPKGNO_01539 1.5e-130 mprF I Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
APPPKGNO_01540 6.8e-26 ykuJ S Protein of unknown function (DUF1797)
APPPKGNO_01541 0.0 ltaS 2.7.8.20 M Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
APPPKGNO_01543 2.1e-07
APPPKGNO_01550 7.4e-177 metK 2.5.1.6 H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
APPPKGNO_01551 0.0 leuS 6.1.1.4 J Belongs to the class-I aminoacyl-tRNA synthetase family
APPPKGNO_01552 2.4e-192 cycA E Amino acid permease
APPPKGNO_01553 2.4e-186 ytgP S Polysaccharide biosynthesis protein
APPPKGNO_01554 2.8e-62 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
APPPKGNO_01555 1.1e-81 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
APPPKGNO_01556 8.7e-193 pepV 3.5.1.18 E dipeptidase PepV
APPPKGNO_01557 6.4e-63 2.1.1.72 V site-specific DNA-methyltransferase (adenine-specific) activity
APPPKGNO_01558 8e-79 L Type III restriction enzyme, res subunit
APPPKGNO_01559 0.0 L Type III restriction enzyme, res subunit
APPPKGNO_01561 4e-36
APPPKGNO_01562 2.6e-66 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
APPPKGNO_01563 4.2e-61 marR K Transcriptional regulator, MarR family
APPPKGNO_01564 7.1e-101 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APPPKGNO_01565 2.2e-27 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
APPPKGNO_01566 6.5e-104 fabD 2.3.1.39 I Malonyl CoA-acyl carrier protein transacylase
APPPKGNO_01567 6.5e-99 IQ reductase
APPPKGNO_01568 1.8e-194 fabF 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
APPPKGNO_01569 7.9e-47 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
APPPKGNO_01570 1.5e-63 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
APPPKGNO_01571 9.3e-216 accC 6.3.4.14, 6.4.1.2 I Acetyl-CoA carboxylase biotin carboxylase subunit
APPPKGNO_01572 2.7e-125 accD 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
APPPKGNO_01573 2.3e-102 accA 2.1.3.15, 6.4.1.2 I alpha subunit
APPPKGNO_01574 5.5e-109 fabI 1.3.1.10, 1.3.1.9 I Enoyl- acyl-carrier-protein reductase NADH
APPPKGNO_01575 2.8e-229 zwf 1.1.1.363, 1.1.1.49 G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
APPPKGNO_01576 3.1e-240 pgi 5.3.1.9 G Belongs to the GPI family
APPPKGNO_01577 4.6e-302 ltaS 2.7.8.20 M Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
APPPKGNO_01578 5.7e-119 gla U Major intrinsic protein
APPPKGNO_01579 5.8e-45 ykuL S CBS domain
APPPKGNO_01580 1.5e-60 dapD 2.3.1.117, 2.3.1.89 E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
APPPKGNO_01581 7.1e-177 hipO 3.5.1.47 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
APPPKGNO_01582 1.5e-86 ykuT M mechanosensitive ion channel
APPPKGNO_01584 5e-285 pbp2A 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
APPPKGNO_01585 2e-21 yheA S Belongs to the UPF0342 family
APPPKGNO_01586 5e-128 yhaM S Metal dependent phosphohydrolases with conserved 'HD' motif.
APPPKGNO_01587 6.6e-114 prsA 5.2.1.8 M Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins
APPPKGNO_01589 5.4e-53 hit FG histidine triad
APPPKGNO_01590 1.3e-94 ecsA V ABC transporter, ATP-binding protein
APPPKGNO_01591 1.4e-71 ecsB U ABC transporter
APPPKGNO_01592 1.6e-98 ytmP 2.7.1.89 M Choline/ethanolamine kinase
APPPKGNO_01593 7.9e-101 trmB 2.1.1.297, 2.1.1.33 J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
APPPKGNO_01594 4e-45 ytpP 2.7.1.180, 5.3.4.1 CO Thioredoxin
APPPKGNO_01595 2.3e-76 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
APPPKGNO_01596 3.8e-238 sftA D Belongs to the FtsK SpoIIIE SftA family
APPPKGNO_01597 7.6e-223 mpl 6.3.2.4, 6.3.2.45, 6.3.2.8 M Belongs to the MurCDEF family
APPPKGNO_01598 2.5e-61 phaJ I N-terminal half of MaoC dehydratase
APPPKGNO_01599 6.7e-69 ybhL S Belongs to the BI1 family
APPPKGNO_01600 0.0 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APPPKGNO_01601 3.3e-107 fpg 3.2.2.23, 4.2.99.18 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
APPPKGNO_01602 2.1e-50 coaE 2.7.1.24 F Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
APPPKGNO_01603 6.1e-66 nrdR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APPPKGNO_01604 1.6e-79 dnaB L replication initiation and membrane attachment
APPPKGNO_01605 2.2e-107 dnaI L Primosomal protein DnaI
APPPKGNO_01606 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
APPPKGNO_01607 1.3e-79 infC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
APPPKGNO_01608 1.4e-24 rpmI J Belongs to the bacterial ribosomal protein bL35 family
APPPKGNO_01609 7.7e-53 rplT J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
APPPKGNO_01610 2.5e-71 yqeG S HAD phosphatase, family IIIA
APPPKGNO_01611 7.9e-181 yqeH S Ribosome biogenesis GTPase YqeH
APPPKGNO_01612 1e-29 yhbY J RNA-binding protein
APPPKGNO_01613 2.7e-77 nadD 2.7.7.18, 3.6.1.55 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
APPPKGNO_01614 7.2e-72 nadD 2.7.6.3, 2.7.7.18 H Hydrolase, HD family
APPPKGNO_01615 1.5e-48 rsfS J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
APPPKGNO_01616 5.5e-82 H Nodulation protein S (NodS)
APPPKGNO_01617 1.3e-122 ylbM S Belongs to the UPF0348 family
APPPKGNO_01618 3.9e-56 yceD S Uncharacterized ACR, COG1399
APPPKGNO_01619 1.9e-25 rpmF J Belongs to the bacterial ribosomal protein bL32 family
APPPKGNO_01620 1.2e-88 plsC 2.3.1.51 I Acyltransferase
APPPKGNO_01621 8.5e-94 yabB 2.1.1.223 L Methyltransferase small domain
APPPKGNO_01622 1.5e-27 yazA L GIY-YIG catalytic domain protein
APPPKGNO_01623 1.9e-128 rpsB J Belongs to the universal ribosomal protein uS2 family
APPPKGNO_01624 2.7e-128 tsf J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
APPPKGNO_01625 6.9e-37
APPPKGNO_01626 3.4e-92 dak 2.7.1.74, 2.7.1.76 F deoxynucleoside kinase
APPPKGNO_01627 1.8e-57 purE 5.4.99.18 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
APPPKGNO_01628 2.7e-157 purK 6.3.4.18 F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
APPPKGNO_01629 1.2e-225 purB 4.3.2.2 F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APPPKGNO_01630 9.5e-106 pacA 3.5.1.24 M Linear amide C-N hydrolase, choloylglycine hydrolase family protein
APPPKGNO_01632 3.1e-111 K response regulator
APPPKGNO_01633 5e-167 arlS 2.7.13.3 T Histidine kinase
APPPKGNO_01634 1.6e-118 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
APPPKGNO_01635 9.7e-24 acyP 3.6.1.7 C Belongs to the acylphosphatase family
APPPKGNO_01636 1.6e-136 mvaS 2.3.3.10 I Hydroxymethylglutaryl-CoA synthase
APPPKGNO_01637 7.3e-105
APPPKGNO_01638 7.2e-117
APPPKGNO_01639 1.3e-41 dut S dUTPase
APPPKGNO_01640 2.1e-94 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APPPKGNO_01641 3.7e-46 yqhY S Asp23 family, cell envelope-related function
APPPKGNO_01642 4.2e-36 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APPPKGNO_01643 3e-103 folD 1.5.1.5, 3.5.4.9 F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
APPPKGNO_01644 2e-146 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
APPPKGNO_01645 1.2e-16 xseB 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
APPPKGNO_01646 1.4e-82 ispA 2.5.1.1, 2.5.1.10, 2.5.1.29, 2.5.1.90 H Belongs to the FPP GGPP synthase family
APPPKGNO_01647 1.2e-120 rrmJ 2.1.1.226, 2.1.1.227 J Ribosomal RNA large subunit methyltransferase J
APPPKGNO_01648 1.5e-48 argR K Regulates arginine biosynthesis genes
APPPKGNO_01649 2.7e-177 recN L May be involved in recombinational repair of damaged DNA
APPPKGNO_01650 7.2e-83 lexA 3.4.21.88 K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APPPKGNO_01651 2.2e-30 ynzC S UPF0291 protein
APPPKGNO_01652 5.9e-27 yneF S UPF0154 protein
APPPKGNO_01653 1.8e-91 engB D Necessary for normal cell division and for the maintenance of normal septation
APPPKGNO_01654 5.4e-44 MA20_27270 S mazG nucleotide pyrophosphohydrolase
APPPKGNO_01655 2.1e-74 yciQ P membrane protein (DUF2207)
APPPKGNO_01656 3e-19 D nuclear chromosome segregation
APPPKGNO_01657 4.2e-21 rpmG J Belongs to the bacterial ribosomal protein bL33 family
APPPKGNO_01658 1.6e-38 ygfA 6.3.3.2 H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APPPKGNO_01659 7.4e-70 gluP 3.4.21.105 S Peptidase, S54 family
APPPKGNO_01660 1.5e-25 yqgQ S Bacterial protein of unknown function (DUF910)
APPPKGNO_01661 4.7e-158 glk 2.7.1.2 G Glucokinase
APPPKGNO_01662 8e-46 yqhL P Rhodanese-like protein
APPPKGNO_01663 9.7e-17 WQ51_02665 S Protein of unknown function (DUF3042)
APPPKGNO_01664 1.9e-111 miaA 2.5.1.75 F Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
APPPKGNO_01665 1.8e-205 ynbB 4.4.1.1 P aluminum resistance
APPPKGNO_01666 1.3e-45 glnR K Transcriptional regulator
APPPKGNO_01667 2e-247 glnA 6.3.1.2 E glutamine synthetase
APPPKGNO_01669 5.8e-37 ogt 2.1.1.63 H Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
APPPKGNO_01670 2.7e-48 S Domain of unknown function (DUF956)
APPPKGNO_01671 6.3e-115 pyrH 2.7.4.22 F Catalyzes the reversible phosphorylation of UMP to UDP
APPPKGNO_01672 7.2e-82 frr J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
APPPKGNO_01673 3.8e-105 uppS 2.5.1.31 H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APPPKGNO_01674 5.1e-102 cdsA 2.7.7.41 S Belongs to the CDS family
APPPKGNO_01675 4.1e-157 rseP 3.4.21.107, 3.4.21.116 M zinc metalloprotease
APPPKGNO_01676 5.9e-260 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
APPPKGNO_01677 0.0 polC 2.7.7.7 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APPPKGNO_01678 8e-66 rimP J Required for maturation of 30S ribosomal subunits
APPPKGNO_01679 4.8e-170 nusA K Participates in both transcription termination and antitermination
APPPKGNO_01680 1.4e-39 ylxR K Protein of unknown function (DUF448)
APPPKGNO_01681 6.8e-26 ylxQ J ribosomal protein
APPPKGNO_01682 0.0 infB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
APPPKGNO_01683 1.3e-55 rbfA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
APPPKGNO_01684 1.4e-119 truB 5.4.99.25 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
APPPKGNO_01685 2.5e-95 ribF 2.7.1.26, 2.7.7.2 H Belongs to the ribF family
APPPKGNO_01686 1.4e-131 hrcA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
APPPKGNO_01687 4.2e-56 grpE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
APPPKGNO_01688 1.5e-274 dnaK O Heat shock 70 kDa protein
APPPKGNO_01689 1.2e-160 dnaJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
APPPKGNO_01690 0.0 lepA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
APPPKGNO_01692 9.2e-206 glnP P ABC transporter
APPPKGNO_01693 2.6e-119 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
APPPKGNO_01694 1.5e-31
APPPKGNO_01695 2e-111 ampC V Beta-lactamase
APPPKGNO_01696 3.5e-110 cobQ S glutamine amidotransferase
APPPKGNO_01697 4.7e-220 murF 6.3.2.10, 6.3.2.13 M Domain of unknown function (DUF1727)
APPPKGNO_01698 6.8e-86 tdk 2.7.1.21 F thymidine kinase
APPPKGNO_01699 1e-177 prfA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
APPPKGNO_01700 1.4e-89 prmB 2.1.1.297, 2.1.1.298 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
APPPKGNO_01701 7.7e-135 ywlC 2.7.7.87, 3.1.3.48 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
APPPKGNO_01702 5e-100 upp 2.4.2.9 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
APPPKGNO_01703 4.5e-97 atpB C it plays a direct role in the translocation of protons across the membrane
APPPKGNO_01704 2.4e-39 atpF C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
APPPKGNO_01705 2.7e-57 atpH C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APPPKGNO_01706 6.3e-266 atpA 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
APPPKGNO_01707 1.3e-141 atpG C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
APPPKGNO_01708 1.7e-236 atpD 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
APPPKGNO_01709 3.9e-48 atpC C Produces ATP from ADP in the presence of a proton gradient across the membrane
APPPKGNO_01710 4.1e-15 ywzB S Protein of unknown function (DUF1146)
APPPKGNO_01711 9.3e-197 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APPPKGNO_01712 3.4e-167 mbl D Cell shape determining protein MreB Mrl
APPPKGNO_01713 1.2e-26 yidD S Could be involved in insertion of integral membrane proteins into the membrane
APPPKGNO_01714 1.8e-12 S Protein of unknown function (DUF2969)
APPPKGNO_01715 6.1e-187 rodA D Belongs to the SEDS family
APPPKGNO_01716 7.9e-26 arsC 1.20.4.1 P Belongs to the ArsC family
APPPKGNO_01717 5.6e-94 2.7.1.89 M Phosphotransferase enzyme family
APPPKGNO_01718 1.1e-102 gmk 2.7.4.8 F Essential for recycling GMP and indirectly, cGMP
APPPKGNO_01719 2.5e-21 rpoZ 2.7.7.6 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
APPPKGNO_01720 4.4e-121 coaBC 4.1.1.36, 6.3.2.5 H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APPPKGNO_01721 2.4e-288 priA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
APPPKGNO_01722 5.8e-140 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
APPPKGNO_01723 6.4e-153 sun 2.1.1.176 J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APPPKGNO_01724 3.3e-90 stp 3.1.3.16 T phosphatase
APPPKGNO_01725 3.4e-191 KLT serine threonine protein kinase
APPPKGNO_01726 1.8e-111 rsgA 3.1.3.100 S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
APPPKGNO_01727 3.8e-58 thiN 2.7.6.2 H thiamine pyrophosphokinase
APPPKGNO_01728 1.4e-26 rpmB J Belongs to the bacterial ribosomal protein bL28 family
APPPKGNO_01729 4.5e-53 asp S Asp23 family, cell envelope-related function
APPPKGNO_01730 3.7e-238 yloV S DAK2 domain fusion protein YloV
APPPKGNO_01731 3.3e-246 recG 3.6.4.12 L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APPPKGNO_01732 2.1e-140 plsX 2.3.1.15 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
APPPKGNO_01733 7e-26 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
APPPKGNO_01734 2.5e-100 rnc 3.1.26.3 J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
APPPKGNO_01735 4.7e-211 smc D Required for chromosome condensation and partitioning
APPPKGNO_01736 9.1e-149 ftsY U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
APPPKGNO_01737 7e-40 ylxM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
APPPKGNO_01738 5e-204 ffh 3.6.5.4 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APPPKGNO_01739 3.6e-42 rpsP J Belongs to the bacterial ribosomal protein bS16 family
APPPKGNO_01740 1.1e-26 ylqC S Belongs to the UPF0109 family
APPPKGNO_01741 1.9e-57 rimM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
APPPKGNO_01742 7.3e-114 trmD 2.1.1.228, 4.6.1.12 J Belongs to the RNA methyltransferase TrmD family
APPPKGNO_01743 5.7e-61 pat 2.3.1.183 M Acetyltransferase (GNAT) domain
APPPKGNO_01744 3.5e-197 yfnA E amino acid
APPPKGNO_01745 3e-57 rplS J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
APPPKGNO_01746 1.8e-32 rpsT J Binds directly to 16S ribosomal RNA
APPPKGNO_01747 5.6e-40 rpsO J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
APPPKGNO_01748 5.3e-116 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APPPKGNO_01749 3.8e-267 rnjB J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
APPPKGNO_01750 4e-18 S Tetratricopeptide repeat
APPPKGNO_01751 1.4e-215 tuf J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APPPKGNO_01752 1.7e-195 tig D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
APPPKGNO_01753 1e-197 clpX O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
APPPKGNO_01754 2.3e-249 gnd 1.1.1.343, 1.1.1.44 H Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
APPPKGNO_01755 1.5e-300 rnjA J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
APPPKGNO_01756 5e-23 ykzG S Belongs to the UPF0356 family
APPPKGNO_01757 1.6e-24
APPPKGNO_01758 8.2e-86 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
APPPKGNO_01759 3.7e-32 1.1.1.27 C L-malate dehydrogenase activity
APPPKGNO_01760 1.7e-23 yktA S Belongs to the UPF0223 family
APPPKGNO_01761 9.7e-77 suhB 3.1.3.25 G Belongs to the inositol monophosphatase superfamily
APPPKGNO_01762 0.0 typA T GTP-binding protein TypA
APPPKGNO_01763 6e-148 manL 2.7.1.191 G PTS system sorbose subfamily IIB component
APPPKGNO_01764 1.6e-114 manY G PTS system
APPPKGNO_01765 3.3e-148 manN G system, mannose fructose sorbose family IID component

eggNOG-mapper v2 (Database: eggNOG v5.0, Jul. 2018 release)