ORF_ID e_value Gene_name EC_number CAZy COGs Description
MEANEGAF_00001 9.1e-31 tnpR1 L Resolvase, N terminal domain
MEANEGAF_00003 1.3e-257 gabD 1.2.1.16, 1.2.1.20, 1.2.1.79 C Belongs to the aldehyde dehydrogenase family
MEANEGAF_00004 2.7e-249 purA 6.3.4.4 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MEANEGAF_00005 7.4e-167 guaC 1.1.1.205, 1.7.1.7 F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
MEANEGAF_00006 1.1e-93 K transcriptional regulator
MEANEGAF_00007 1.7e-128 ybhF_2 V AAA domain, putative AbiEii toxin, Type IV TA system
MEANEGAF_00008 1e-188 ybhR V ABC transporter
MEANEGAF_00009 1.7e-65 arsC 1.20.4.1 P Belongs to the ArsC family
MEANEGAF_00010 6.5e-293 glpQ 3.1.4.46 C phosphodiesterase
MEANEGAF_00011 2.6e-163 yvgN C Aldo keto reductase
MEANEGAF_00012 0.0 addA 3.6.4.12 L ATP-dependent helicase nuclease subunit A
MEANEGAF_00013 0.0 rexB 3.1.21.3, 3.6.4.12 L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' - 3' nuclease activity
MEANEGAF_00014 8.8e-281 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MEANEGAF_00015 0.0 clpL O associated with various cellular activities
MEANEGAF_00016 1e-34
MEANEGAF_00017 7.2e-217 patA 2.6.1.1 E Aminotransferase
MEANEGAF_00018 4.1e-181 ldhD 1.1.1.28 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MEANEGAF_00019 2.4e-183 D Alpha beta
MEANEGAF_00020 1.8e-189 pacA 3.5.1.24 M Linear amide C-N hydrolase, choloylglycine hydrolase family protein
MEANEGAF_00021 4.8e-109 ysdA CP transmembrane transport
MEANEGAF_00022 1.4e-116 pgmB 2.4.1.64, 3.1.3.12, 3.2.1.28, 5.4.2.6 GH37,GH65 S beta-phosphoglucomutase
MEANEGAF_00023 0.0 mapA 2.4.1.8 GH65 G hydrolase, family 65, central catalytic
MEANEGAF_00024 3e-251 malT G Major Facilitator
MEANEGAF_00025 3.2e-175 malR K Transcriptional regulator, LacI family
MEANEGAF_00026 5.7e-71 K Transcriptional regulator
MEANEGAF_00027 6.8e-81 rlmH 2.1.1.177 J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MEANEGAF_00028 3e-208 htrA 3.4.21.107 O serine protease
MEANEGAF_00029 6e-154 vicX 3.1.26.11 S domain protein
MEANEGAF_00030 9.4e-144 yycI S YycH protein
MEANEGAF_00031 3e-240 yycH S YycH protein
MEANEGAF_00032 0.0 vicK 2.7.13.3 T Histidine kinase
MEANEGAF_00033 6.8e-130 K response regulator
MEANEGAF_00036 6.3e-50
MEANEGAF_00037 8.8e-207 lmrP E Major Facilitator Superfamily
MEANEGAF_00038 2.4e-243 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
MEANEGAF_00039 3.4e-74 rplI J Binds to the 23S rRNA
MEANEGAF_00040 0.0 yybT T signaling protein consisting of a modified GGDEF domain and a DHH domain
MEANEGAF_00043 5.9e-10 isp2 L PFAM transposase, IS204 IS1001 IS1096 IS1165 family protein
MEANEGAF_00044 3.2e-142 EG EamA-like transporter family
MEANEGAF_00045 1.6e-257 XK27_04775 S PAS domain
MEANEGAF_00046 1.8e-18 M1-755 S Domain of unknown function (DUF1858)
MEANEGAF_00047 8e-54 yitW S Iron-sulfur cluster assembly protein
MEANEGAF_00048 2.6e-230 ndh 1.6.99.3 C NADH dehydrogenase
MEANEGAF_00049 7.7e-143 fecE 3.6.3.34 HP AAA domain, putative AbiEii toxin, Type IV TA system
MEANEGAF_00050 3.3e-170 fecD P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MEANEGAF_00051 2.2e-72 moaE 2.8.1.12 H MoaE protein
MEANEGAF_00052 6.4e-35 moaD 2.8.1.12 H ThiS family
MEANEGAF_00053 3.5e-196 moaA 4.1.99.22 H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MEANEGAF_00054 3.6e-216 narK P Major Facilitator Superfamily
MEANEGAF_00055 1.5e-58 yitW S Iron-sulfur cluster assembly protein
MEANEGAF_00056 4.5e-163 hipB K Helix-turn-helix
MEANEGAF_00057 4.6e-134 menG 2.1.1.163, 2.1.1.201 H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)
MEANEGAF_00059 2e-169 hepT 2.5.1.30, 2.5.1.90 H geranyltranstransferase activity
MEANEGAF_00060 1.5e-183
MEANEGAF_00061 1.2e-39
MEANEGAF_00062 8.9e-116 nreC K PFAM regulatory protein LuxR
MEANEGAF_00063 3.9e-182 comP 2.7.13.3 F Sensor histidine kinase
MEANEGAF_00064 1.4e-77 nreA T GAF domain
MEANEGAF_00065 4.2e-40
MEANEGAF_00066 1.1e-98 mobA 2.7.7.77 H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
MEANEGAF_00067 9.3e-85 moaC 4.6.1.17 H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)
MEANEGAF_00068 1.5e-230 moeA 2.10.1.1 H MoeA N-terminal region (domain I and II)
MEANEGAF_00069 1.9e-86 moaB 2.7.7.75 H May be involved in the biosynthesis of molybdopterin
MEANEGAF_00070 1.4e-189 moeB 2.7.7.73, 2.7.7.80 H ThiF family
MEANEGAF_00071 0.0 narG 1.7.5.1 C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MEANEGAF_00072 0.0 narH 1.7.5.1 C Respiratory nitrate reductase beta C-terminal
MEANEGAF_00073 3.1e-102 narJ C Nitrate reductase delta subunit
MEANEGAF_00074 2.1e-128 narI 1.7.5.1 C Nitrate reductase
MEANEGAF_00075 1.3e-184
MEANEGAF_00076 1.7e-75
MEANEGAF_00077 2.1e-65 yjcE P Sodium proton antiporter
MEANEGAF_00078 3.1e-39 ywnB S NAD(P)H-binding
MEANEGAF_00080 2.8e-290 gshF 6.3.2.2 H Belongs to the glutamate--cysteine ligase type 1 family
MEANEGAF_00081 2.2e-96 V VanZ like family
MEANEGAF_00082 2.8e-221 aspB 2.6.1.1, 2.6.1.14 E Aminotransferase
MEANEGAF_00083 2.5e-61 yneR
MEANEGAF_00084 1.4e-181 K Transcriptional regulator, LacI family
MEANEGAF_00085 3.2e-229 gntT EG Gluconate
MEANEGAF_00086 5.3e-289 gntK 2.7.1.12, 2.7.1.17 G Belongs to the FGGY kinase family
MEANEGAF_00087 9.6e-172 mutR K Transcriptional activator, Rgg GadR MutR family
MEANEGAF_00088 4.8e-88 3.6.3.6 P ATPase, P-type transporting, HAD superfamily, subfamily IC
MEANEGAF_00090 1e-78 copY K Copper transport repressor CopY TcrY
MEANEGAF_00091 3.9e-41
MEANEGAF_00092 2.3e-170 GK ROK family
MEANEGAF_00093 2.3e-130 1.14.12.17 C Oxidoreductase NAD-binding domain
MEANEGAF_00094 2.8e-310 ubiB S ABC1 family
MEANEGAF_00095 3.3e-103 wecD3 K Acetyltransferase (GNAT) family
MEANEGAF_00096 4.9e-69 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
MEANEGAF_00097 1.4e-54 crcB D Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MEANEGAF_00098 2.9e-54 crcB U Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MEANEGAF_00099 1.1e-169 apbE 2.7.1.180 H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
MEANEGAF_00100 3.5e-180 dapF 5.1.1.7 E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MEANEGAF_00101 4.5e-263 lysC 2.7.2.4 E Belongs to the aspartokinase family
MEANEGAF_00102 2.4e-253 lysA 4.1.1.19, 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
MEANEGAF_00103 2.9e-72 dapD 2.3.1.117, 2.3.1.89 E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
MEANEGAF_00104 4.9e-218 hipO 3.5.1.47 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
MEANEGAF_00105 9.2e-175 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MEANEGAF_00106 2.8e-140 dapB 1.17.1.8 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
MEANEGAF_00107 6.5e-218 patA 2.6.1.1 E Aminotransferase
MEANEGAF_00108 1.5e-197 asd 1.2.1.11 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MEANEGAF_00109 6.7e-227 ktrB P Potassium uptake protein
MEANEGAF_00110 1.7e-117 ktrA P domain protein
MEANEGAF_00111 2.9e-125 trmK 2.1.1.217 S SAM-dependent methyltransferase
MEANEGAF_00112 1.7e-156 yqfO 3.5.4.16 S Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MEANEGAF_00113 2.8e-235 pepT 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
MEANEGAF_00115 0.0 dnaE 2.7.7.7 L DNA polymerase
MEANEGAF_00116 2.4e-267 pyk 2.7.1.40, 2.7.7.4 G Belongs to the pyruvate kinase family
MEANEGAF_00117 1.6e-168 cvfB S S1 domain
MEANEGAF_00118 5.3e-132 xerD D recombinase XerD
MEANEGAF_00119 5.3e-68 ribT K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
MEANEGAF_00120 6.6e-142 scpA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MEANEGAF_00121 4.7e-100 scpB D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MEANEGAF_00122 2.8e-131 rluB 5.4.99.19, 5.4.99.21, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
MEANEGAF_00123 3.7e-81 U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
MEANEGAF_00124 6e-199 ypbB 5.1.3.1 S Helix-turn-helix domain
MEANEGAF_00125 2e-277 recQ1 3.6.4.12 L ATP-dependent DNA helicase RecQ
MEANEGAF_00126 9.7e-31 M Lysin motif
MEANEGAF_00127 5.8e-118 cmk 1.17.7.4, 2.5.1.19, 2.7.1.26, 2.7.4.25, 2.7.7.2, 6.3.2.1 F Belongs to the cytidylate kinase family. Type 1 subfamily
MEANEGAF_00128 5.8e-209 rpsA 1.17.7.4 J Ribosomal protein S1
MEANEGAF_00129 5.7e-247 der 1.1.1.399, 1.1.1.95 S GTPase that plays an essential role in the late steps of ribosome biogenesis
MEANEGAF_00130 4.4e-40 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
MEANEGAF_00131 6.9e-234 S Tetratricopeptide repeat protein
MEANEGAF_00132 4.7e-165 xerD L Phage integrase, N-terminal SAM-like domain
MEANEGAF_00133 5.3e-223 cca 2.7.7.19, 2.7.7.72 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
MEANEGAF_00134 0.0 yfmR S ABC transporter, ATP-binding protein
MEANEGAF_00135 1.8e-189 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MEANEGAF_00136 8.7e-95 folA 1.5.1.3 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MEANEGAF_00137 2.7e-109 hlyIII S protein, hemolysin III
MEANEGAF_00138 4e-153 DegV S EDD domain protein, DegV family
MEANEGAF_00139 2.9e-218 1.1.1.399, 1.1.1.95 EH D-isomer specific 2-hydroxyacid dehydrogenase
MEANEGAF_00140 2.2e-108 cat S Bacterial transferase hexapeptide (six repeats)
MEANEGAF_00141 1.1e-167 ypmR E lipolytic protein G-D-S-L family
MEANEGAF_00142 7.1e-104 ypmS S Uncharacterized protein conserved in bacteria (DUF2140)
MEANEGAF_00143 3.1e-36 yozE S Belongs to the UPF0346 family
MEANEGAF_00144 2.4e-161 ylqF S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MEANEGAF_00145 1.2e-140 rnhB 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MEANEGAF_00146 4.4e-83 dprA LU DNA protecting protein DprA
MEANEGAF_00147 9.7e-134 manR K PRD domain
MEANEGAF_00148 3.3e-18 H Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
MEANEGAF_00149 2.6e-53 2.7.1.202 G Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
MEANEGAF_00150 2.5e-39 fruA 2.7.1.202 G PTS system, Lactose/Cellobiose specific IIB subunit
MEANEGAF_00151 1.4e-126 G Phosphotransferase System
MEANEGAF_00152 1.1e-108 alsE 5.1.3.1 G Ribulose-phosphate 3 epimerase family
MEANEGAF_00153 1.2e-131 2.7.1.202 G Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
MEANEGAF_00154 6.1e-44 2.7.1.194, 2.7.1.202 G Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
MEANEGAF_00155 2.8e-40 ulaB 2.7.1.194 G Phosphotransferase system galactitol-specific IIB component
MEANEGAF_00156 3.7e-193 ulaA 2.7.1.194 S PTS system sugar-specific permease component
MEANEGAF_00157 4.4e-259 tkt 2.2.1.1 H Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MEANEGAF_00158 7.8e-123 rpiA 2.7.1.12, 5.3.1.6 G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MEANEGAF_00159 2e-135 tal 2.2.1.2 H Transaldolase/Fructose-6-phosphate aldolase
MEANEGAF_00160 0.0 tkt 2.2.1.1 H Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MEANEGAF_00161 2.1e-244 glpT G Major Facilitator Superfamily
MEANEGAF_00162 9.7e-130 qmcA O prohibitin homologues
MEANEGAF_00164 3.1e-75 uspA T universal stress protein
MEANEGAF_00165 1.8e-58
MEANEGAF_00166 2.5e-19
MEANEGAF_00167 2.1e-157
MEANEGAF_00168 8.4e-75 K Transcriptional regulator
MEANEGAF_00169 1.1e-183 D Alpha beta
MEANEGAF_00170 3.9e-72 O OsmC-like protein
MEANEGAF_00171 7.6e-191 lplA2 6.3.1.20 H Bacterial lipoate protein ligase C-terminus
MEANEGAF_00172 0.0 yjcE P Sodium proton antiporter
MEANEGAF_00173 1.7e-15 yvlA
MEANEGAF_00174 7e-113 P Cobalt transport protein
MEANEGAF_00175 2.8e-252 cbiO1 S ABC transporter, ATP-binding protein
MEANEGAF_00176 2.3e-99 S ABC-type cobalt transport system, permease component
MEANEGAF_00177 2.8e-179 iunH2 3.2.2.1 F nucleoside hydrolase
MEANEGAF_00178 1.3e-182 yumC 1.18.1.2, 1.19.1.1, 1.8.1.9 C Ferredoxin--NADP reductase
MEANEGAF_00179 0.0 cadA 3.6.3.3, 3.6.3.5 P P-type ATPase
MEANEGAF_00180 2.8e-32 copZ P Heavy-metal-associated domain
MEANEGAF_00181 2.6e-100 dps P Belongs to the Dps family
MEANEGAF_00182 1.6e-107 rcfA 4.1.99.16, 4.2.3.22, 4.2.3.75 K helix_turn_helix, cAMP Regulatory protein
MEANEGAF_00183 8.5e-57
MEANEGAF_00184 2.3e-14
MEANEGAF_00185 0.0 ltaS 2.7.8.20 M Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
MEANEGAF_00186 3.6e-125 pgm3 G phosphoglycerate mutase family
MEANEGAF_00187 9.7e-147 qorB 1.6.5.2 GM NmrA-like family
MEANEGAF_00188 5.6e-96 L PFAM Integrase catalytic region
MEANEGAF_00190 1.9e-229 pbuX F xanthine permease
MEANEGAF_00191 6.3e-168 corA P CorA-like Mg2+ transporter protein
MEANEGAF_00192 5.1e-167 rluA 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
MEANEGAF_00193 4.9e-140 terC P membrane
MEANEGAF_00194 6.6e-56 trxA1 O Belongs to the thioredoxin family
MEANEGAF_00195 2.3e-148 S Uncharacterised 5xTM membrane BCR, YitT family COG1284
MEANEGAF_00196 5.3e-133 S Membrane
MEANEGAF_00197 3.3e-76 4.4.1.5 E Glyoxalase
MEANEGAF_00198 4.5e-85 yueI S Protein of unknown function (DUF1694)
MEANEGAF_00199 4.9e-235 rarA L recombination factor protein RarA
MEANEGAF_00201 2.3e-81 usp6 T universal stress protein
MEANEGAF_00202 2.9e-151 2.3.1.19 K Helix-turn-helix XRE-family like proteins
MEANEGAF_00203 7.7e-216 ddl 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
MEANEGAF_00204 1.5e-180 S Protein of unknown function (DUF2785)
MEANEGAF_00206 5.8e-222 rodA D Belongs to the SEDS family
MEANEGAF_00207 7.9e-32 S Protein of unknown function (DUF2969)
MEANEGAF_00208 2.6e-183 mbl D Cell shape determining protein MreB Mrl
MEANEGAF_00209 1.2e-219 murA 2.5.1.7 M EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
MEANEGAF_00210 2.8e-29 S Protein of unknown function (DUF1146)
MEANEGAF_00211 8.4e-67 atpC C Produces ATP from ADP in the presence of a proton gradient across the membrane
MEANEGAF_00212 4.4e-253 atpD 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MEANEGAF_00213 2.3e-165 atpG C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MEANEGAF_00214 4e-284 atpA 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MEANEGAF_00215 3.7e-91 atpH C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MEANEGAF_00216 3.7e-53 atpF C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MEANEGAF_00217 1.2e-16 atpE C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MEANEGAF_00218 5.8e-129 atpB C it plays a direct role in the translocation of protons across the membrane
MEANEGAF_00219 5.4e-218 pyrP F Permease
MEANEGAF_00220 5.5e-125 yibF S overlaps another CDS with the same product name
MEANEGAF_00221 2.2e-183 yibE S overlaps another CDS with the same product name
MEANEGAF_00222 1.2e-114 upp 2.4.2.9 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MEANEGAF_00223 5e-229 glyA 2.1.2.1 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MEANEGAF_00224 2.6e-194 ywlC 2.7.7.87, 3.1.3.48 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
MEANEGAF_00225 7.1e-158 prmB 2.1.1.297, 2.1.1.298 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
MEANEGAF_00226 7.2e-155 prfA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MEANEGAF_00227 1.2e-108 tdk 2.7.1.21 F thymidine kinase
MEANEGAF_00228 4.9e-262 murF 6.3.2.10, 6.3.2.13 M Domain of unknown function (DUF1727)
MEANEGAF_00229 3.4e-140 cobQ S CobB/CobQ-like glutamine amidotransferase domain
MEANEGAF_00230 2.8e-48
MEANEGAF_00231 7.8e-285 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MEANEGAF_00232 9.7e-194 ampC V Beta-lactamase
MEANEGAF_00233 0.0 yfiC V ABC transporter
MEANEGAF_00234 0.0 lmrA V ABC transporter, ATP-binding protein
MEANEGAF_00235 1.8e-78 K Winged helix DNA-binding domain
MEANEGAF_00236 2.3e-07
MEANEGAF_00238 3.6e-57
MEANEGAF_00240 3.3e-132 budA 4.1.1.5 H Belongs to the alpha-acetolactate decarboxylase family
MEANEGAF_00241 1.7e-145 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
MEANEGAF_00242 4e-161 ytbE 1.1.1.346 S Aldo keto reductase
MEANEGAF_00243 1e-122 XK27_08875 O PFAM peptidase M10A and M12B, matrixin and adamalysin
MEANEGAF_00244 1e-84 K GNAT family
MEANEGAF_00246 1.5e-74
MEANEGAF_00247 2.2e-31 ykzG S Belongs to the UPF0356 family
MEANEGAF_00248 3.4e-188 ytlR 2.7.1.91 I Diacylglycerol kinase catalytic
MEANEGAF_00249 4.2e-74 spx4 1.20.4.1 P ArsC family
MEANEGAF_00250 1.8e-176 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MEANEGAF_00251 0.0 recD 3.1.11.5 L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
MEANEGAF_00252 7.1e-124 S Repeat protein
MEANEGAF_00253 4.1e-121 pgm6 5.4.2.11, 5.4.2.12 G phosphoglycerate mutase
MEANEGAF_00254 4.4e-169 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
MEANEGAF_00255 8.6e-306 S amidohydrolase
MEANEGAF_00256 1.4e-222 mnmA 2.8.1.13 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
MEANEGAF_00257 3.4e-58 XK27_04120 S Putative amino acid metabolism
MEANEGAF_00258 1.3e-125 mtnN 3.2.2.9 E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MEANEGAF_00260 2.7e-97 nudF 3.6.1.13 L ADP-ribose pyrophosphatase
MEANEGAF_00261 1.2e-32 cspB K Cold shock protein
MEANEGAF_00262 0.0 ileS 6.1.1.5 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MEANEGAF_00264 4.8e-112 divIVA D DivIVA domain protein
MEANEGAF_00265 4.9e-145 ylmH S S4 domain protein
MEANEGAF_00266 6.8e-41 yggT S YGGT family
MEANEGAF_00267 2.7e-74 sepF D Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
MEANEGAF_00268 9e-221 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MEANEGAF_00269 3.2e-224 ftsA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
MEANEGAF_00270 5.4e-150 divIB D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
MEANEGAF_00271 1.5e-203 murG 2.4.1.227, 6.3.2.8 GT28 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MEANEGAF_00272 4.3e-261 murD 6.3.2.9 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MEANEGAF_00273 1.4e-178 mraY 2.7.8.13 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MEANEGAF_00274 0.0 ftsI 3.4.16.4 M Penicillin-binding Protein
MEANEGAF_00275 7e-09 ftsL D Cell division protein FtsL
MEANEGAF_00276 4.3e-172 rsmH 2.1.1.199 J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
MEANEGAF_00277 5.6e-79 mraZ K Belongs to the MraZ family
MEANEGAF_00278 1.1e-56
MEANEGAF_00279 1.2e-07 S Protein of unknown function (DUF4044)
MEANEGAF_00280 0.0 ftsK D Belongs to the FtsK SpoIIIE SftA family
MEANEGAF_00281 6.7e-95 trmL 2.1.1.207 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
MEANEGAF_00282 2.2e-162 rrmA 2.1.1.187 H Methyltransferase
MEANEGAF_00283 5.2e-195 pgl 3.1.1.31 G Lactonase, 7-bladed beta-propeller
MEANEGAF_00284 8.2e-173 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 G Responsible for synthesis of pseudouridine from uracil
MEANEGAF_00285 1e-153 nadK 2.7.1.23 F Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MEANEGAF_00286 6e-123 yjbM 2.7.6.5 S RelA SpoT domain protein
MEANEGAF_00287 3.6e-114 yjbH Q Thioredoxin
MEANEGAF_00288 3.2e-205 coiA 3.6.4.12 S Competence protein
MEANEGAF_00289 5.3e-114 mecA NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
MEANEGAF_00290 1.7e-69 spxA 1.20.4.1 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
MEANEGAF_00291 3.5e-16 traP 1.14.99.57, 6.2.1.3 S enzyme involved in biosynthesis of extracellular polysaccharides
MEANEGAF_00311 1.7e-249 EGP Major facilitator Superfamily
MEANEGAF_00312 6e-185 ribF 2.7.1.26, 2.7.7.2 H Belongs to the ribF family
MEANEGAF_00313 5.7e-166 truB 5.4.99.25 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MEANEGAF_00314 4.2e-59 rbfA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MEANEGAF_00315 0.0 infB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MEANEGAF_00316 3.2e-50 ylxQ J ribosomal protein
MEANEGAF_00317 1.4e-47 ylxR K Protein of unknown function (DUF448)
MEANEGAF_00318 3.7e-224 nusA K Participates in both transcription termination and antitermination
MEANEGAF_00319 3.3e-83 rimP J Required for maturation of 30S ribosomal subunits
MEANEGAF_00320 0.0 carB 6.3.5.5 F Carbamoyl-phosphate synthase
MEANEGAF_00321 2.8e-207 carA 6.3.5.5 F Carbamoyl-phosphate synthetase glutamine chain
MEANEGAF_00322 9.4e-197 argC 1.2.1.38 E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MEANEGAF_00323 2.4e-207 argJ 2.3.1.1, 2.3.1.35, 2.7.2.8 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MEANEGAF_00324 8e-137 argB 2.7.2.8 F Belongs to the acetylglutamate kinase family. ArgB subfamily
MEANEGAF_00325 8.3e-218 argD 2.6.1.11, 2.6.1.17 E acetylornithine
MEANEGAF_00326 0.0 polC 2.7.7.7 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MEANEGAF_00327 0.0 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
MEANEGAF_00328 4.2e-231 rseP 3.4.21.107, 3.4.21.116 M zinc metalloprotease
MEANEGAF_00329 2.3e-134 cdsA 2.7.7.41 I Belongs to the CDS family
MEANEGAF_00330 5.9e-143 uppS 2.5.1.31 H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MEANEGAF_00331 4.1e-93 frr J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
MEANEGAF_00332 7e-130 pyrH 2.7.4.22 F Catalyzes the reversible phosphorylation of UMP to UDP
MEANEGAF_00333 3.2e-153 tsf J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MEANEGAF_00334 1.5e-141 rpsB J Belongs to the universal ribosomal protein uS2 family
MEANEGAF_00335 8.7e-47 yazA L GIY-YIG catalytic domain protein
MEANEGAF_00336 1.2e-135 yabB 2.1.1.223 L Methyltransferase small domain
MEANEGAF_00337 3.3e-115 plsC 2.3.1.51 I Acyltransferase
MEANEGAF_00338 2.7e-27 yneF S Uncharacterised protein family (UPF0154)
MEANEGAF_00339 2.4e-37 ynzC S UPF0291 protein
MEANEGAF_00340 4.2e-115 lexA 3.4.21.88 K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MEANEGAF_00341 1.6e-216 mvaS 2.3.3.10 I Hydroxymethylglutaryl-CoA synthase
MEANEGAF_00342 5.6e-122 lutA C Cysteine-rich domain
MEANEGAF_00343 5.8e-243 lutB C 4Fe-4S dicluster domain
MEANEGAF_00344 1.7e-86 yrjD S LUD domain
MEANEGAF_00345 1.5e-36 UW LPXTG-motif cell wall anchor domain protein
MEANEGAF_00347 5.8e-44 M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MEANEGAF_00348 2.7e-25 yitW S Iron-sulfur cluster assembly protein
MEANEGAF_00349 2.1e-91 sdaAA 4.3.1.17 E L-serine dehydratase, iron-sulfur-dependent, alpha subunit
MEANEGAF_00350 4.8e-64 sdaAB 4.3.1.17 E Serine dehydratase beta chain
MEANEGAF_00353 1e-19 L Transposase
MEANEGAF_00354 6e-20 L Transposase
MEANEGAF_00355 1.6e-202 rfbX S Membrane protein involved in the export of O-antigen and teichoic acid
MEANEGAF_00356 6.6e-220 glf 5.4.99.9 M UDP-galactopyranose mutase
MEANEGAF_00357 2.5e-52 cps3I G Acyltransferase family
MEANEGAF_00358 4.5e-45 M biosynthesis protein
MEANEGAF_00359 2.5e-95 cps3F
MEANEGAF_00360 1e-147 cps1D M Domain of unknown function (DUF4422)
MEANEGAF_00361 1.1e-118 rfbP M Bacterial sugar transferase
MEANEGAF_00362 4.2e-147 recX 2.4.1.337 GT4 S Regulatory protein RecX
MEANEGAF_00363 1.3e-07
MEANEGAF_00364 3.8e-31 S Protein of unknown function (DUF2922)
MEANEGAF_00365 9.2e-140 yihY S Belongs to the UPF0761 family
MEANEGAF_00366 0.0 XK27_08315 M Sulfatase
MEANEGAF_00367 5.9e-168 map 3.4.11.18 E Methionine Aminopeptidase
MEANEGAF_00368 8.5e-78 fld C Flavodoxin
MEANEGAF_00369 1.1e-72 gtcA S Teichoic acid glycosylation protein
MEANEGAF_00371 8.9e-232 yfmL 3.6.4.13 L DEAD DEAH box helicase
MEANEGAF_00372 6.4e-190 mocA S Oxidoreductase
MEANEGAF_00373 4.9e-63 S Domain of unknown function (DUF4828)
MEANEGAF_00374 1.4e-104 yvdD 3.2.2.10 S Belongs to the LOG family
MEANEGAF_00375 1.9e-161 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
MEANEGAF_00376 7.4e-291 gshF 6.3.2.2 H Belongs to the glutamate--cysteine ligase type 1 family
MEANEGAF_00377 1.4e-139 S NADPH-dependent FMN reductase
MEANEGAF_00378 2.3e-33 yneR S Belongs to the HesB IscA family
MEANEGAF_00379 8.2e-304 ybiT S ABC transporter, ATP-binding protein
MEANEGAF_00380 2e-85 dps P Belongs to the Dps family
MEANEGAF_00381 1.6e-105
MEANEGAF_00382 9.5e-183 brpA K Cell envelope-like function transcriptional attenuator common domain protein
MEANEGAF_00383 1.4e-101 K helix_turn_helix multiple antibiotic resistance protein
MEANEGAF_00384 3.4e-49 fsr EGP Major Facilitator Superfamily
MEANEGAF_00385 3.6e-79 fsr EGP Major Facilitator Superfamily
MEANEGAF_00386 1.1e-97 ogt 2.1.1.63, 3.2.2.20 L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MEANEGAF_00387 7.8e-103 S CAAX protease self-immunity
MEANEGAF_00389 6.3e-120 Q Methyltransferase domain
MEANEGAF_00390 8.6e-91 1.5.1.40 S NADP oxidoreductase coenzyme F420-dependent
MEANEGAF_00391 2.8e-51 K 2 iron, 2 sulfur cluster binding
MEANEGAF_00392 0.0 mco Q Multicopper oxidase
MEANEGAF_00393 1.4e-89 S Aminoacyl-tRNA editing domain
MEANEGAF_00394 5.9e-74 ddaH 3.5.3.18 E Amidinotransferase
MEANEGAF_00396 4.6e-194 nhaC C Na H antiporter NhaC
MEANEGAF_00397 3.1e-177 S Phosphotransferase system, EIIC
MEANEGAF_00398 5.1e-22 D mRNA cleavage
MEANEGAF_00399 1.9e-21 2.3.1.15 D Antitoxin component of a toxin-antitoxin (TA) module
MEANEGAF_00400 1.2e-16 gntT EG gluconate transmembrane transporter activity
MEANEGAF_00401 6.9e-47
MEANEGAF_00402 9.2e-273 tagE3 2.4.1.52 GT4 M Glycosyl transferases group 1
MEANEGAF_00403 1.6e-261 tagE2 2.4.1.52 GT4 M Poly(Glycerol-phosphate) alpha-glucosyltransferase
MEANEGAF_00404 3e-148 metQ1 P Belongs to the nlpA lipoprotein family
MEANEGAF_00405 4.2e-192 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MEANEGAF_00406 1.2e-97 metI P ABC transporter permease
MEANEGAF_00407 4.4e-219 argE 3.5.1.18 E succinyl-diaminopimelate desuccinylase
MEANEGAF_00408 7.6e-245 rumA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MEANEGAF_00409 5.7e-197 brnQ U Component of the transport system for branched-chain amino acids
MEANEGAF_00410 1.1e-122 iolS C Aldo keto reductase
MEANEGAF_00411 3.2e-242 dltD M Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MEANEGAF_00412 1.2e-35 dltC 6.1.1.13 J Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MEANEGAF_00413 3.5e-238 dltB M MBOAT, membrane-bound O-acyltransferase family
MEANEGAF_00414 8.3e-298 dltA 6.1.1.13 H Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MEANEGAF_00416 2.5e-219 sbcD L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
MEANEGAF_00417 0.0 sbcC L Putative exonuclease SbcCD, C subunit
MEANEGAF_00418 2.1e-230 serS 6.1.1.11 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MEANEGAF_00420 1.4e-189 trpS 6.1.1.2 J Belongs to the class-I aminoacyl-tRNA synthetase family
MEANEGAF_00422 8.9e-225 glnP P ABC transporter
MEANEGAF_00423 1.2e-137 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
MEANEGAF_00424 1.2e-250 cycA E Amino acid permease
MEANEGAF_00425 8.4e-213 nupG F Nucleoside transporter
MEANEGAF_00426 2.2e-144 rihC 3.2.2.1 F Nucleoside
MEANEGAF_00427 2e-132 rsmG 2.1.1.170 J Specifically methylates the N7 position of a guanine in 16S rRNA
MEANEGAF_00428 3.5e-158 noc K Belongs to the ParB family
MEANEGAF_00429 1.1e-147 spo0J K Belongs to the ParB family
MEANEGAF_00430 7.9e-31 yyzM S Bacterial protein of unknown function (DUF951)
MEANEGAF_00431 2e-200 ychF J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
MEANEGAF_00432 2.7e-135 XK27_01040 S Protein of unknown function (DUF1129)
MEANEGAF_00433 3.8e-207 guaB 1.1.1.205 F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
MEANEGAF_00434 5.6e-197 1.1.1.1, 1.1.1.14 E alcohol dehydrogenase
MEANEGAF_00435 0.0 pepN 3.4.11.2 E aminopeptidase
MEANEGAF_00436 7.4e-15 tlpA2 L Transposase IS200 like
MEANEGAF_00437 2e-204 L transposase, IS605 OrfB family
MEANEGAF_00438 2e-59 K Transcriptional regulator
MEANEGAF_00439 3.9e-24 phaG GT1 I carboxylic ester hydrolase activity
MEANEGAF_00440 2.1e-140 nfrA 1.5.1.38, 1.5.1.39 C nitroreductase
MEANEGAF_00442 1.4e-153 metQ_4 P Belongs to the nlpA lipoprotein family
MEANEGAF_00443 2.6e-203 napA P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
MEANEGAF_00444 0.0 helD 3.6.4.12 L DNA helicase
MEANEGAF_00445 5.3e-170 ppx 3.6.1.11, 3.6.1.40 FP exopolyphosphatase
MEANEGAF_00446 1.4e-213 mvaA 1.1.1.34, 1.1.1.88, 2.3.1.9 C Belongs to the HMG-CoA reductase family
MEANEGAF_00447 7.2e-186
MEANEGAF_00448 1.1e-127 cobB K SIR2 family
MEANEGAF_00449 5.3e-212 norA EGP Major facilitator Superfamily
MEANEGAF_00450 2.1e-162 yunF F Protein of unknown function DUF72
MEANEGAF_00451 0.0 metG 6.1.1.10 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MEANEGAF_00452 1.8e-147 tatD L hydrolase, TatD family
MEANEGAF_00453 1.9e-98 rnmV 3.1.26.8 J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MEANEGAF_00454 2.1e-160 ksgA 2.1.1.182 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
MEANEGAF_00455 1.3e-159 ispE 2.1.1.182, 2.7.1.148 F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MEANEGAF_00456 1.4e-167 znuA P Belongs to the bacterial solute-binding protein 9 family
MEANEGAF_00457 5.4e-95 fhuC P ABC transporter
MEANEGAF_00458 3.2e-128 znuB U ABC 3 transport family
MEANEGAF_00459 7.5e-152 purR 2.4.2.22, 2.4.2.7 F pur operon repressor
MEANEGAF_00460 1.3e-204 glmU 2.3.1.157, 2.7.7.23 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MEANEGAF_00461 3.6e-177 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MEANEGAF_00462 3e-32
MEANEGAF_00463 1.1e-142 yxeH S hydrolase
MEANEGAF_00464 5.7e-266 ywfO S HD domain protein
MEANEGAF_00465 1.6e-73 ywiB S Domain of unknown function (DUF1934)
MEANEGAF_00466 1.6e-47 rpoE K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
MEANEGAF_00467 4.4e-311 pyrG 6.3.4.2 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
MEANEGAF_00468 6.7e-237 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MEANEGAF_00469 6e-41 rpmE2 J Ribosomal protein L31
MEANEGAF_00470 4e-51 mdtG EGP Major facilitator Superfamily
MEANEGAF_00471 1.9e-77 mdtG EGP Major facilitator Superfamily
MEANEGAF_00472 1.1e-78 tspO T TspO/MBR family
MEANEGAF_00473 3.2e-13
MEANEGAF_00474 3.5e-69 L PFAM transposase, IS204 IS1001 IS1096 IS1165 family protein
MEANEGAF_00475 3.8e-128 L Transposase
MEANEGAF_00479 1.3e-102 clpP 3.4.21.92 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
MEANEGAF_00480 7.2e-118 tenA 3.5.99.2 K Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MEANEGAF_00481 1.9e-167 whiA K May be required for sporulation
MEANEGAF_00482 3.2e-186 ybhK S Required for morphogenesis under gluconeogenic growth conditions
MEANEGAF_00483 6.6e-159 rapZ S Displays ATPase and GTPase activities
MEANEGAF_00484 4.9e-204
MEANEGAF_00485 0.0 uvrA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
MEANEGAF_00486 0.0 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
MEANEGAF_00488 6.8e-113 yfbR S HD containing hydrolase-like enzyme
MEANEGAF_00489 0.0 pgm 5.4.2.2, 5.4.2.8 G Phosphoglucomutase phosphomannomutase, alpha beta alpha domain
MEANEGAF_00490 2.8e-137 cof S haloacid dehalogenase-like hydrolase
MEANEGAF_00491 1.6e-171 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
MEANEGAF_00492 3.8e-198 ilvE 2.6.1.42 E Branched-chain amino acid aminotransferase
MEANEGAF_00493 1.8e-37 L Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
MEANEGAF_00494 1.5e-26 L Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
MEANEGAF_00495 3.4e-169 cysK 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
MEANEGAF_00496 2.1e-154 metAA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to
MEANEGAF_00497 2.6e-132 trxB 1.8.1.9 C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
MEANEGAF_00498 6.7e-77 yphH S Cupin domain
MEANEGAF_00499 7.6e-188 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MEANEGAF_00500 1.4e-225 mtnE 2.6.1.83 E Aminotransferase
MEANEGAF_00501 2.3e-147 mtnU 3.5.1.3 S Carbon-nitrogen hydrolase
MEANEGAF_00502 2.1e-171 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
MEANEGAF_00503 1.5e-183 gpsA 1.1.1.94 I Glycerol-3-phosphate dehydrogenase
MEANEGAF_00504 4.7e-162 lgt 2.1.1.199 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MEANEGAF_00505 3.2e-178 hprK F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MEANEGAF_00506 1.2e-47 yvlD S Mycobacterial 4 TMS phage holin, superfamily IV
MEANEGAF_00507 4.1e-53 KT PspC domain protein
MEANEGAF_00508 4.5e-202 prfB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MEANEGAF_00509 0.0 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
MEANEGAF_00510 6.5e-96 hpf J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MEANEGAF_00511 4e-127 comFC S Competence protein
MEANEGAF_00512 7.7e-252 comFA L Helicase C-terminal domain protein
MEANEGAF_00513 9e-113 yvyE 3.4.13.9 S YigZ family
MEANEGAF_00514 6.4e-38
MEANEGAF_00515 0.0 ydaO E amino acid
MEANEGAF_00516 4.7e-291 groL O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
MEANEGAF_00517 7.4e-43 groS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MEANEGAF_00518 4.4e-115 rex K Modulates transcription in response to changes in cellular NADH NAD( ) redox state
MEANEGAF_00519 0.0 uup S ABC transporter, ATP-binding protein
MEANEGAF_00520 5.6e-175 birA 6.3.4.15 H Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
MEANEGAF_00521 9.7e-92 bioY S BioY family
MEANEGAF_00522 1.5e-135 fabI 1.3.1.10, 1.3.1.9 I Enoyl- acyl-carrier-protein reductase NADH
MEANEGAF_00523 6.7e-139 accA 2.1.3.15, 6.4.1.2 I alpha subunit
MEANEGAF_00524 1.5e-160 accD 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MEANEGAF_00525 4.6e-263 accC 6.3.4.14, 6.4.1.2 I Acetyl-CoA carboxylase biotin carboxylase subunit
MEANEGAF_00526 1.3e-75 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
MEANEGAF_00527 1.6e-63 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
MEANEGAF_00528 6e-230 fabF 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
MEANEGAF_00529 7.8e-129 IQ reductase
MEANEGAF_00530 7.4e-172 fabD 2.3.1.39 I Malonyl CoA-acyl carrier protein transacylase
MEANEGAF_00531 4.2e-34 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
MEANEGAF_00532 2.8e-171 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MEANEGAF_00533 8.7e-75 marR K Transcriptional regulator, MarR family
MEANEGAF_00534 2.7e-76 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
MEANEGAF_00536 3.4e-194 tsaD 2.3.1.234 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MEANEGAF_00537 2.5e-109 rimI 2.3.1.128 K Ribosomal-protein-alanine acetyltransferase
MEANEGAF_00538 3.2e-130 yeaZ 2.3.1.234 O Universal bacterial protein YeaZ
MEANEGAF_00539 7.6e-216 arcT 2.6.1.1 E Aminotransferase
MEANEGAF_00540 7.8e-221 yxjG 2.1.1.14 E methionine synthase, vitamin-B12 independent
MEANEGAF_00541 1.1e-259 E Arginine ornithine antiporter
MEANEGAF_00542 8.2e-240 arcA 3.5.3.6 E Arginine
MEANEGAF_00543 1.4e-167 arcC 2.7.2.2 E Belongs to the carbamate kinase family
MEANEGAF_00544 6e-188 argF 2.1.3.3 E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MEANEGAF_00545 3e-148 KT YcbB domain
MEANEGAF_00546 1e-192 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
MEANEGAF_00547 6.7e-173 ppx 3.6.1.11, 3.6.1.40 FP exopolyphosphatase
MEANEGAF_00548 0.0 ppk 2.7.4.1 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MEANEGAF_00549 2.1e-282 ppx3 3.6.1.11, 3.6.1.40 FP exopolyphosphatase
MEANEGAF_00550 3.3e-146 fat 3.1.2.21 I Acyl-ACP thioesterase
MEANEGAF_00551 1.2e-157 rsmI 2.1.1.198 H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MEANEGAF_00552 1.5e-55 yabA L Involved in initiation control of chromosome replication
MEANEGAF_00553 1.9e-192 holB 2.7.7.7 L DNA polymerase III
MEANEGAF_00554 4e-53 yaaQ S Cyclic-di-AMP receptor
MEANEGAF_00555 6.7e-116 tmk 2.7.4.9 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MEANEGAF_00556 2.4e-21 S Protein of unknown function (DUF2508)
MEANEGAF_00557 3e-110 recR L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MEANEGAF_00558 4.9e-40 yaaK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MEANEGAF_00559 0.0 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MEANEGAF_00561 6.3e-80 tadA 3.5.4.33 F Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
MEANEGAF_00562 2e-35 nrdH O Glutaredoxin
MEANEGAF_00563 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MEANEGAF_00564 1.9e-194 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MEANEGAF_00565 2.4e-248 brnQ U Component of the transport system for branched-chain amino acids
MEANEGAF_00566 0.0 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
MEANEGAF_00567 0.0 cydD CO ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MEANEGAF_00568 0.0 cydD CO ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydD
MEANEGAF_00569 4.1e-176 cydB 1.10.3.14 C Cytochrome d ubiquinol oxidase subunit II
MEANEGAF_00570 1.1e-272 cydA 1.10.3.14 C ubiquinol oxidase
MEANEGAF_00571 4.6e-53 rplL J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
MEANEGAF_00572 4.2e-81 rplJ J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MEANEGAF_00573 4.6e-244 steT E amino acid
MEANEGAF_00574 7.4e-121 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
MEANEGAF_00575 2.2e-51 rplK J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MEANEGAF_00576 4.5e-97 nusG K Participates in transcription elongation, termination and antitermination
MEANEGAF_00577 2.4e-23 secE U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
MEANEGAF_00578 3.2e-21 rpmG J Belongs to the bacterial ribosomal protein bL33 family
MEANEGAF_00579 1.1e-104 sigH K Belongs to the sigma-70 factor family
MEANEGAF_00580 1.5e-135 rlmB 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MEANEGAF_00581 5.5e-71 mrnC J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MEANEGAF_00582 1.7e-273 cysS 6.1.1.16, 6.3.1.13 J Belongs to the class-I aminoacyl-tRNA synthetase family
MEANEGAF_00583 7.8e-100 ywlG S Belongs to the UPF0340 family
MEANEGAF_00584 6.2e-290 gltX 6.1.1.17, 6.1.1.24 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MEANEGAF_00585 3.2e-206 yacL S domain protein
MEANEGAF_00586 1.6e-252 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MEANEGAF_00587 1.4e-98 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F dUTP diphosphatase
MEANEGAF_00588 4.2e-55 HA62_12640 S GCN5-related N-acetyl-transferase
MEANEGAF_00589 1.3e-122 rpiA 2.7.1.12, 5.3.1.6 G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MEANEGAF_00590 4.1e-94 maa 2.3.1.18, 2.3.1.79 S Transferase hexapeptide repeat
MEANEGAF_00591 4e-264 pepC 3.4.22.40 E Peptidase C1-like family
MEANEGAF_00592 1.5e-166 I alpha/beta hydrolase fold
MEANEGAF_00593 1.4e-127 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MEANEGAF_00594 3.8e-168 mleP2 S Sodium Bile acid symporter family
MEANEGAF_00595 1.2e-188 lacM 3.2.1.23, 3.2.1.35, 3.2.1.51, 3.2.1.97 GH101,GH29 G beta-galactosidase
MEANEGAF_00596 0.0 lacL 3.2.1.23 G Belongs to the glycosyl hydrolase 2 family
MEANEGAF_00598 2.4e-83 ydcK S Belongs to the SprT family
MEANEGAF_00599 0.0 yhgF K Tex-like protein N-terminal domain protein
MEANEGAF_00600 8.8e-153 nadE 6.3.1.5 F Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
MEANEGAF_00601 5e-284 pncB 6.3.4.21 F Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MEANEGAF_00602 1.4e-127 gntR1 K UbiC transcription regulator-associated domain protein
MEANEGAF_00603 4.3e-132 racD 5.1.1.13 M Belongs to the aspartate glutamate racemases family
MEANEGAF_00604 9.6e-115
MEANEGAF_00607 7.1e-166 yjjH S Calcineurin-like phosphoesterase
MEANEGAF_00608 4.7e-90 2.4.2.6 F nucleoside 2-deoxyribosyltransferase
MEANEGAF_00609 4.9e-30 EGP Major facilitator Superfamily
MEANEGAF_00610 0.0 copA 3.6.3.54 P P-type ATPase
MEANEGAF_00611 5e-53 silP 1.9.3.1, 3.6.3.54 S Cupredoxin-like domain
MEANEGAF_00612 3.8e-47 silP 1.9.3.1, 3.6.3.54 S Cupredoxin-like domain
MEANEGAF_00613 1.1e-178
MEANEGAF_00614 7.9e-224 patA 2.6.1.1, 2.6.1.57 E Aminotransferase
MEANEGAF_00615 1.6e-131 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MEANEGAF_00616 1.7e-240 purD 6.3.4.13 F Belongs to the GARS family
MEANEGAF_00617 7.8e-296 purH 2.1.2.3, 3.5.4.10 F Bifunctional purine biosynthesis protein PurH
MEANEGAF_00618 6e-108 purN 2.1.2.2 F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MEANEGAF_00619 1.1e-197 purM 6.3.3.1, 6.3.4.13 F Phosphoribosylformylglycinamidine cyclo-ligase
MEANEGAF_00620 2.8e-279 purF 2.4.2.14 F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MEANEGAF_00621 0.0 purL 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MEANEGAF_00622 1.6e-128 purQ 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MEANEGAF_00623 3e-37 purS 6.3.2.6, 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MEANEGAF_00624 2.5e-135 purC 4.1.1.21, 4.3.2.2, 6.3.2.6 F Belongs to the SAICAR synthetase family
MEANEGAF_00625 3e-19 K HxlR-like helix-turn-helix
MEANEGAF_00626 7.3e-31 nagZ 3.2.1.52 G Glycosyl hydrolase family 3 N terminal domain
MEANEGAF_00627 1.2e-235 S response to antibiotic
MEANEGAF_00628 1e-171 hrpQ 4.6.1.1 T histone H2A K63-linked ubiquitination
MEANEGAF_00629 3.3e-255 purB 4.3.2.2 F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MEANEGAF_00630 1.3e-215 purK 6.3.4.18 F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MEANEGAF_00631 5.3e-81 purE 5.4.99.18 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MEANEGAF_00632 0.0 fhs 6.3.4.3 F Belongs to the formate--tetrahydrofolate ligase family
MEANEGAF_00633 2.8e-164 K AI-2E family transporter
MEANEGAF_00634 3.1e-10 K transcriptional regulator
MEANEGAF_00635 5.7e-230 cfa 2.1.1.317, 2.1.1.79 M cyclopropane-fatty-acyl-phospholipid synthase
MEANEGAF_00636 5.1e-101 ydeN S Serine hydrolase
MEANEGAF_00637 8.9e-61 azlD S branched-chain amino acid
MEANEGAF_00638 2.8e-146 azlC E AzlC protein
MEANEGAF_00639 5.9e-196 dacA 3.4.16.4 M Belongs to the peptidase S11 family
MEANEGAF_00640 5.9e-208 hpk31 2.7.13.3 T Histidine kinase
MEANEGAF_00641 1e-122 K response regulator
MEANEGAF_00642 6.3e-93 S Cupin superfamily (DUF985)
MEANEGAF_00644 7.9e-39 L Transposase
MEANEGAF_00645 2.7e-57 S Domain of unknown function (DUF956)
MEANEGAF_00646 3e-170 manN G system, mannose fructose sorbose family IID component
MEANEGAF_00647 2.7e-122 manY G PTS system
MEANEGAF_00648 3.4e-180 manL 2.7.1.191 G PTS system sorbose subfamily IIB component
MEANEGAF_00649 8.7e-181 yfeX P Peroxidase
MEANEGAF_00650 1.1e-89 racA K Domain of unknown function (DUF1836)
MEANEGAF_00651 2.5e-147 yitS S EDD domain protein, DegV family
MEANEGAF_00652 2.2e-131 manA 5.3.1.8 G mannose-6-phosphate isomerase
MEANEGAF_00653 2.8e-168 K LysR substrate binding domain
MEANEGAF_00654 9.2e-160 MA20_14895 S Conserved hypothetical protein 698
MEANEGAF_00655 2.4e-75 lytE M Lysin motif
MEANEGAF_00656 4e-150 XK27_02985 S Sucrose-6F-phosphate phosphohydrolase
MEANEGAF_00657 3.2e-211 oatA I Acyltransferase
MEANEGAF_00658 3.3e-52
MEANEGAF_00659 0.0 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
MEANEGAF_00660 1.2e-252 glmM 5.4.2.10 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MEANEGAF_00661 9.1e-116 ybbR S YbbR-like protein
MEANEGAF_00662 1.1e-147 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MEANEGAF_00663 5.7e-166 murB 1.3.1.98 M Cell wall formation
MEANEGAF_00664 9.6e-100 dnaQ 2.7.7.7 L DNA polymerase III
MEANEGAF_00665 2.8e-88 K Acetyltransferase (GNAT) domain
MEANEGAF_00666 2.9e-81 ydiB 2.7.1.221, 5.1.1.1 O Hydrolase, P-loop family
MEANEGAF_00667 2.4e-178 pta 2.3.1.8, 3.6.3.21 C phosphate acetyltransferase
MEANEGAF_00668 2.8e-136 ung 3.2.2.27 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MEANEGAF_00669 1.1e-109 yxjI
MEANEGAF_00670 2.9e-84 smpB J the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
MEANEGAF_00671 0.0 rnr J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
MEANEGAF_00672 4.5e-33 secG U Preprotein translocase
MEANEGAF_00673 8.4e-290 clcA P chloride
MEANEGAF_00674 1.5e-253 yifK E Amino acid permease
MEANEGAF_00675 1e-248 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
MEANEGAF_00676 2.6e-143 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
MEANEGAF_00677 1.9e-225 pgk 2.7.2.3, 5.3.1.1 F Belongs to the phosphoglycerate kinase family
MEANEGAF_00678 4.5e-191 gap 1.2.1.12 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
MEANEGAF_00679 1e-15
MEANEGAF_00680 8.3e-24 L Plasmid pRiA4b ORF-3-like protein
MEANEGAF_00681 2e-61
MEANEGAF_00682 5.4e-192 hrcA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
MEANEGAF_00683 4.9e-57 grpE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MEANEGAF_00684 0.0 dnaK O Heat shock 70 kDa protein
MEANEGAF_00685 1.1e-177 dnaJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
MEANEGAF_00686 2.4e-95 hisH E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MEANEGAF_00687 2.9e-08 hisF 3.5.4.19, 3.6.1.31 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
MEANEGAF_00688 5e-51 hisF 3.5.4.19, 3.6.1.31 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
MEANEGAF_00689 7.5e-168 hisK 3.1.3.15 E Histidinol phosphate phosphatase, HisJ
MEANEGAF_00690 8.4e-218 hisZ 2.4.2.17, 6.1.1.21 E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
MEANEGAF_00691 5.8e-109 hisG 2.4.2.17 F Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
MEANEGAF_00692 4.4e-228 hisD 1.1.1.23, 1.1.1.308 E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MEANEGAF_00693 1.9e-101 hisB 1.1.1.23, 2.6.1.9, 3.1.3.15, 4.2.1.19 E imidazoleglycerol-phosphate dehydratase
MEANEGAF_00694 1.2e-111 hisH E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MEANEGAF_00695 2.7e-129 hisA 5.3.1.16 E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MEANEGAF_00696 1.9e-141 hisF 3.5.4.19, 3.6.1.31 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
MEANEGAF_00697 8.5e-56 hisI 3.5.4.19, 3.5.4.25, 3.6.1.31, 5.3.1.16 E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MEANEGAF_00698 3.7e-51 hisE 3.5.4.19, 3.6.1.31, 5.3.1.16 E phosphoribosyl-ATP diphosphatase activity
MEANEGAF_00699 1.1e-200 hisC 2.6.1.9 E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MEANEGAF_00700 0.0 lepA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
MEANEGAF_00701 5.6e-09
MEANEGAF_00702 1.9e-112 3.1.3.73 G phosphoglycerate mutase
MEANEGAF_00703 3.2e-112 C aldo keto reductase
MEANEGAF_00704 5.4e-203 serC 2.6.1.52 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MEANEGAF_00705 4.8e-221 serA 1.1.1.399, 1.1.1.95 EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MEANEGAF_00706 7.1e-269 K COG COG0846 NAD-dependent protein deacetylases, SIR2 family
MEANEGAF_00707 2.1e-79 K 2 iron, 2 sulfur cluster binding
MEANEGAF_00708 1.9e-80 ribH 2.5.1.78 H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
MEANEGAF_00709 1e-226 ribBA 3.5.4.25, 4.1.99.12 H Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate
MEANEGAF_00710 1.2e-106 ribE 2.5.1.9, 3.5.4.25, 4.1.99.12 H Riboflavin synthase
MEANEGAF_00711 2.2e-201 ribD 1.1.1.193, 3.5.4.26 H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MEANEGAF_00712 8.5e-55 C FMN binding
MEANEGAF_00713 1.8e-62 T His Kinase A (phosphoacceptor) domain
MEANEGAF_00714 2.1e-49 T Transcriptional regulatory protein, C terminal
MEANEGAF_00715 1.2e-15 S ABC-type transport system involved in multi-copper enzyme maturation permease component
MEANEGAF_00716 4.8e-221 iscS 2.8.1.7 E Aminotransferase class V
MEANEGAF_00718 8.1e-23 nlhH_1 I acetylesterase activity
MEANEGAF_00719 1.1e-20 nlhH_1 I acetylesterase activity
MEANEGAF_00720 5.6e-216 lacZ 3.2.1.23 G Domain of unknown function (DUF4982)
MEANEGAF_00721 2.2e-147 iolF EGP Major facilitator Superfamily
MEANEGAF_00722 1.3e-173 xynB 3.2.1.37, 3.2.1.55 GH43,GH51 G Belongs to the glycosyl hydrolase 43 family
MEANEGAF_00723 8.1e-136 uhpT EGP Major Facilitator Superfamily
MEANEGAF_00724 3.1e-80 K AraC-like ligand binding domain
MEANEGAF_00725 8.4e-267 3.2.1.52 G Glycosyl hydrolase family 3 N terminal domain
MEANEGAF_00726 0.0 3.2.1.40 G Alpha-L-rhamnosidase N-terminal domain
MEANEGAF_00727 1.6e-50 nlhH_1 I Carboxylesterase family
MEANEGAF_00728 3e-107 ppiB 5.2.1.8 G PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MEANEGAF_00729 0.0 scrA 2.7.1.211, 5.3.1.1 G phosphotransferase system
MEANEGAF_00730 4.7e-196 adhA 1.1.1.1 C Zinc-binding alcohol dehydrogenase family protein
MEANEGAF_00731 2e-296 scrB 3.2.1.26 GH32 G invertase
MEANEGAF_00732 1.2e-260 S Uncharacterized protein conserved in bacteria (DUF2252)
MEANEGAF_00733 3.2e-164 K LysR substrate binding domain
MEANEGAF_00734 6.8e-164 S Polyphosphate nucleotide phosphotransferase, PPK2 family
MEANEGAF_00735 3.9e-110
MEANEGAF_00737 6.2e-266 yjeM E Amino Acid
MEANEGAF_00738 3.7e-168 ponA V Beta-lactamase enzyme family
MEANEGAF_00739 1.7e-224 dacA 3.4.16.4 M Belongs to the peptidase S11 family
MEANEGAF_00740 5.9e-97
MEANEGAF_00741 2.3e-198 pgl 3.1.1.31 G Lactonase, 7-bladed beta-propeller
MEANEGAF_00742 4.7e-108 lssY 3.6.1.27 I Acid phosphatase homologues
MEANEGAF_00743 1.6e-54 S MazG-like family
MEANEGAF_00744 7.5e-183 L Helicase C-terminal domain protein
MEANEGAF_00745 9.2e-79 natA S Domain of unknown function (DUF4162)
MEANEGAF_00746 9.3e-58 ysdA CP transmembrane transport
MEANEGAF_00747 1.6e-61 L Helix-turn-helix domain
MEANEGAF_00748 2.4e-133 L hmm pf00665
MEANEGAF_00749 2.2e-11 S Domain of unknown function (DUF771)
MEANEGAF_00751 2.7e-11 XK27_10050 K Peptidase S24-like
MEANEGAF_00752 3.9e-09 E Zn peptidase
MEANEGAF_00753 9.9e-91 L Belongs to the 'phage' integrase family
MEANEGAF_00755 8.4e-60 S Fic/DOC family
MEANEGAF_00757 1.5e-39
MEANEGAF_00759 2.6e-81 S Fic/DOC family
MEANEGAF_00760 8.4e-17 V CAAX protease self-immunity
MEANEGAF_00761 8.7e-07
MEANEGAF_00763 2.8e-25 M Peptidase family M23
MEANEGAF_00765 8e-189 U type IV secretory pathway VirB4
MEANEGAF_00766 5.3e-34
MEANEGAF_00768 4e-60
MEANEGAF_00769 2.8e-238 U TraM recognition site of TraD and TraG
MEANEGAF_00772 2.7e-37 S Phage derived protein Gp49-like (DUF891)
MEANEGAF_00773 4.2e-19 K Helix-turn-helix XRE-family like proteins
MEANEGAF_00775 3.3e-152 tesE Q hydratase
MEANEGAF_00776 8.6e-187 ldhA 1.1.1.28 C Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MEANEGAF_00777 2.9e-60 S Domain of unknown function (DUF4440)
MEANEGAF_00778 2.6e-94 apt 2.4.2.22, 2.4.2.7 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MEANEGAF_00779 0.0 recJ L Single-stranded-DNA-specific exonuclease RecJ
MEANEGAF_00780 1.9e-155 XK27_05435 1.1.1.100 S Belongs to the short-chain dehydrogenases reductases (SDR) family
MEANEGAF_00781 8.3e-176 rnz 3.1.26.11 J Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
MEANEGAF_00782 4.8e-246 obg S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MEANEGAF_00783 0.0 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
MEANEGAF_00784 3.3e-135 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
MEANEGAF_00786 8.3e-53 MA20_27270 S mazG nucleotide pyrophosphohydrolase
MEANEGAF_00787 2.8e-108 engB D Necessary for normal cell division and for the maintenance of normal septation
MEANEGAF_00788 1.5e-233 clpX O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MEANEGAF_00789 5.7e-215 tig D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
MEANEGAF_00790 4.3e-225 tuf J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MEANEGAF_00791 1.2e-163 S Tetratricopeptide repeat
MEANEGAF_00792 0.0 rnjB J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MEANEGAF_00793 1.5e-261 gshF 6.3.2.2 H Belongs to the glutamate--cysteine ligase type 1 family
MEANEGAF_00794 4.6e-42 rpsO J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MEANEGAF_00795 2.3e-35 rpsT J Binds directly to 16S ribosomal RNA
MEANEGAF_00796 1.8e-184 holA 2.7.7.7 L DNA polymerase III delta subunit
MEANEGAF_00797 3e-193 L Belongs to the 'phage' integrase family
MEANEGAF_00798 4.2e-30 K Helix-turn-helix XRE-family like proteins
MEANEGAF_00799 1.6e-14 S Helix-turn-helix domain
MEANEGAF_00801 2.3e-50 L DNA replication protein
MEANEGAF_00802 2.5e-197 merA 1.16.1.1, 1.8.1.7 C Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
MEANEGAF_00803 1.1e-198 L Psort location Cytoplasmic, score
MEANEGAF_00804 4e-33
MEANEGAF_00805 0.0 traI 5.99.1.2 L This gene contains a nucleotide ambiguity which may be the result of a sequencing error
MEANEGAF_00806 2.1e-67
MEANEGAF_00807 4.4e-152
MEANEGAF_00808 1.8e-63
MEANEGAF_00809 5.1e-255 traK U TraM recognition site of TraD and TraG
MEANEGAF_00811 1.2e-77
MEANEGAF_00812 1.9e-88
MEANEGAF_00813 1.1e-193 M CHAP domain
MEANEGAF_00814 1.3e-217 polC 2.4.1.129, 2.7.7.7, 3.4.16.4 GT51 S WXG100 protein secretion system (Wss), protein YukC
MEANEGAF_00815 0.0 traE U AAA-like domain
MEANEGAF_00816 8.9e-116
MEANEGAF_00817 1.9e-35
MEANEGAF_00818 2.7e-52 S Cag pathogenicity island, type IV secretory system
MEANEGAF_00819 6.6e-105
MEANEGAF_00820 1.8e-50
MEANEGAF_00821 0.0 L MobA MobL family protein
MEANEGAF_00822 3.2e-27
MEANEGAF_00823 6.8e-41
MEANEGAF_00824 3e-114 S protein conserved in bacteria
MEANEGAF_00825 1.1e-26
MEANEGAF_00826 1.6e-42 relB L Addiction module antitoxin, RelB DinJ family
MEANEGAF_00827 1.3e-162 repA S Replication initiator protein A
MEANEGAF_00828 1.7e-35
MEANEGAF_00829 2.6e-149 D CobQ CobB MinD ParA nucleotide binding domain protein
MEANEGAF_00830 1.2e-48 yefM 2.3.1.15 D Antitoxin component of a toxin-antitoxin (TA) module
MEANEGAF_00831 0.0 pacL 3.6.3.8, 3.6.3.9 P Cation transporter/ATPase, N-terminus
MEANEGAF_00833 0.0 norZ 1.7.2.5 P Cytochrome C and Quinol oxidase polypeptide I
MEANEGAF_00834 5.7e-270 guaA 2.3.1.128, 6.3.5.2 F Catalyzes the synthesis of GMP from XMP
MEANEGAF_00835 7.8e-114 2.7.6.5 T Region found in RelA / SpoT proteins
MEANEGAF_00836 1.8e-16 K response regulator
MEANEGAF_00837 2.1e-52 K response regulator
MEANEGAF_00838 4.2e-130 sptS 2.7.13.3 T Histidine kinase
MEANEGAF_00839 2.9e-173 coaA 2.7.1.33 F Pantothenic acid kinase
MEANEGAF_00840 8.6e-104 2.3.1.128 K acetyltransferase
MEANEGAF_00841 0.0 ltaS 2.7.8.20 M Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
MEANEGAF_00842 5.6e-161 EG EamA-like transporter family
MEANEGAF_00843 0.0 helD 3.6.4.12 L DNA helicase
MEANEGAF_00844 1.2e-115 dedA S SNARE associated Golgi protein
MEANEGAF_00845 4e-121 pgm7 5.4.2.11, 5.4.2.12 G phosphoglycerate mutase
MEANEGAF_00846 1.2e-230 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MEANEGAF_00847 5.7e-208 menC 4.2.1.113 H Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)
MEANEGAF_00848 1.2e-134 pnuC H nicotinamide mononucleotide transporter
MEANEGAF_00849 7.8e-299 ybeC E amino acid
MEANEGAF_00850 2.5e-253 yifK E Amino acid permease
MEANEGAF_00852 0.0 dxs 2.2.1.7 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MEANEGAF_00853 3.5e-238 N Uncharacterized conserved protein (DUF2075)
MEANEGAF_00855 4.5e-79 ndk 2.7.4.6 F Belongs to the NDK family
MEANEGAF_00856 2.2e-99 padR K Virulence activator alpha C-term
MEANEGAF_00857 1.2e-82 padC Q Phenolic acid decarboxylase
MEANEGAF_00859 5e-220 I transferase activity, transferring acyl groups other than amino-acyl groups
MEANEGAF_00861 1.8e-142 ET Bacterial periplasmic substrate-binding proteins
MEANEGAF_00862 4.7e-159 gshF 6.3.2.2 H Belongs to the glutamate--cysteine ligase type 1 family
MEANEGAF_00863 3.2e-225 aadAT EK Aminotransferase, class I
MEANEGAF_00865 1.6e-10
MEANEGAF_00867 1.1e-30 S Sugar efflux transporter for intercellular exchange
MEANEGAF_00868 2.5e-104 tdh 1.1.1.14 E Alcohol dehydrogenase GroES-like domain
MEANEGAF_00869 1.9e-37 tdh 1.1.1.14 C Zinc-binding dehydrogenase
MEANEGAF_00870 2e-260 guaD 3.5.4.3 F Amidohydrolase family
MEANEGAF_00871 4.1e-217 argE 3.5.1.18 E succinyl-diaminopimelate desuccinylase
MEANEGAF_00873 1.6e-57 arsC 1.20.4.1 T Low molecular weight phosphotyrosine protein phosphatase
MEANEGAF_00874 1.3e-112 glpQ1 3.1.4.46 C glycerophosphoryl diester phosphodiesterase
MEANEGAF_00875 3.4e-47 yrfB C NADH:flavin oxidoreductase / NADH oxidase family
MEANEGAF_00876 3.4e-39 rmeB K transcriptional regulator, MerR family
MEANEGAF_00877 7.1e-36 rmeB K transcriptional regulator, MerR family
MEANEGAF_00878 2.5e-133 ybbM S Uncharacterised protein family (UPF0014)
MEANEGAF_00879 1.4e-107 ybbL S ABC transporter, ATP-binding protein
MEANEGAF_00881 2.2e-152 mleP3 S Membrane transport protein
MEANEGAF_00882 1.3e-51 trxA O Belongs to the thioredoxin family
MEANEGAF_00883 2.6e-255 gor 1.8.1.7 C pyridine nucleotide-disulfide oxidoreductase
MEANEGAF_00884 5.1e-207 EGP Major facilitator Superfamily
MEANEGAF_00885 2e-206 ycsG P Natural resistance-associated macrophage protein
MEANEGAF_00886 2e-124 ycsF S LamB/YcsF family
MEANEGAF_00887 7.6e-258 accC 6.3.4.14, 6.4.1.2 I Acetyl-CoA carboxylase biotin carboxylase subunit
MEANEGAF_00888 4.8e-54 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
MEANEGAF_00889 2.5e-189 kipA 6.3.4.6 E Allophanate hydrolase subunit 2
MEANEGAF_00890 1e-133 ybgJ 3.5.1.54 E Allophanate hydrolase subunit 1
MEANEGAF_00891 2.3e-72 K helix_turn_helix, mercury resistance
MEANEGAF_00892 5.9e-82 S Psort location Cytoplasmic, score
MEANEGAF_00893 3.2e-286 dinB 2.7.7.7 L impB/mucB/samB family C-terminal domain
MEANEGAF_00894 1e-66 wecD K Acetyltransferase (GNAT) family
MEANEGAF_00895 6.4e-105 3.2.1.17 NU mannosyl-glycoprotein
MEANEGAF_00896 3.9e-195 asnA 6.3.1.1 F aspartate--ammonia ligase
MEANEGAF_00897 2e-10 yjjG 3.1.3.102, 3.1.3.104, 3.1.3.5, 3.8.1.2 S HAD-hyrolase-like
MEANEGAF_00898 4.9e-215 2.1.1.14 E methionine synthase, vitamin-B12 independent
MEANEGAF_00899 3e-89 luxS 4.4.1.21 H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
MEANEGAF_00900 3.5e-38 S Cytochrome B5
MEANEGAF_00902 9.4e-14 S Domain of unknown function (DUF4811)
MEANEGAF_00903 3e-216 lmrB EGP Major facilitator Superfamily
MEANEGAF_00904 7.8e-142 Z012_07420 3.1.21.5 V Z1 domain
MEANEGAF_00907 3.3e-45 V Abi-like protein
MEANEGAF_00908 4.4e-62
MEANEGAF_00909 4.3e-200 S Phage integrase family
MEANEGAF_00910 6.6e-93 dut S Protein conserved in bacteria
MEANEGAF_00911 5.1e-176
MEANEGAF_00912 2.4e-148
MEANEGAF_00913 4.7e-13
MEANEGAF_00914 2.6e-263 glnA 6.3.1.2 E glutamine synthetase
MEANEGAF_00915 8.5e-173 miaA 2.5.1.75 F Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MEANEGAF_00916 4.8e-24 WQ51_02665 S Protein of unknown function (DUF3042)
MEANEGAF_00917 1.5e-71 yqhL P Rhodanese-like protein
MEANEGAF_00918 1.2e-180 glk 2.7.1.2 G Glucokinase
MEANEGAF_00919 9.6e-36 yqgQ S Bacterial protein of unknown function (DUF910)
MEANEGAF_00920 1.1e-116 gluP 3.4.21.105 S Peptidase, S54 family
MEANEGAF_00921 4.1e-98 ygfA 6.3.3.2 H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MEANEGAF_00922 3.2e-21 rpmG J Belongs to the bacterial ribosomal protein bL33 family
MEANEGAF_00923 0.0 pbp2b 3.4.16.4 M Penicillin-binding Protein
MEANEGAF_00924 0.0 S membrane
MEANEGAF_00925 1.1e-78 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
MEANEGAF_00926 5.2e-116 udk 2.7.1.48 F Cytidine monophosphokinase
MEANEGAF_00927 0.0 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
MEANEGAF_00928 4.3e-197 pheS 6.1.1.20 J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MEANEGAF_00929 7.8e-60 yodB K Transcriptional regulator, HxlR family
MEANEGAF_00930 1.3e-90 XK27_09705 6.1.1.14 S Metal dependent phosphohydrolases with conserved 'HD' motif.
MEANEGAF_00931 3.7e-140 spoU 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MEANEGAF_00932 4.1e-46 acyP 3.6.1.7 C Belongs to the acylphosphatase family
MEANEGAF_00933 2.2e-141 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
MEANEGAF_00934 3e-69 def_1 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins
MEANEGAF_00935 4.7e-233 V MatE
MEANEGAF_00936 9e-281 arlS 2.7.13.3 T Histidine kinase
MEANEGAF_00937 5.6e-121 K response regulator
MEANEGAF_00938 7.2e-28 rpmF J Belongs to the bacterial ribosomal protein bL32 family
MEANEGAF_00939 1e-96 yceD S Uncharacterized ACR, COG1399
MEANEGAF_00940 3.2e-214 ylbM S Belongs to the UPF0348 family
MEANEGAF_00941 2e-140 yqeM Q Methyltransferase
MEANEGAF_00942 6.1e-58 rsfS J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
MEANEGAF_00943 2.8e-111 nadD 2.7.6.3, 2.7.7.18 H Hydrolase, HD family
MEANEGAF_00944 2.7e-93 nadD 2.7.7.18, 3.6.1.55 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MEANEGAF_00945 2.6e-49 yhbY J RNA-binding protein
MEANEGAF_00946 7.6e-216 yqeH S Ribosome biogenesis GTPase YqeH
MEANEGAF_00947 2.2e-96 yqeG S HAD phosphatase, family IIIA
MEANEGAF_00948 1.9e-19 yoaK S Protein of unknown function (DUF1275)
MEANEGAF_00949 6.6e-57 rplT J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MEANEGAF_00950 1.5e-26 rpmI J Belongs to the bacterial ribosomal protein bL35 family
MEANEGAF_00951 1.7e-85 infC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MEANEGAF_00952 2.5e-172 dnaI L Primosomal protein DnaI
MEANEGAF_00953 1e-251 dnaB L replication initiation and membrane attachment
MEANEGAF_00954 8.5e-81 nrdR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MEANEGAF_00955 5.1e-105 coaE 2.7.1.24 F Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MEANEGAF_00956 1.8e-161 fpg 3.2.2.23, 4.2.99.18 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
MEANEGAF_00957 0.0 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MEANEGAF_00958 1.1e-138 aroD S Serine hydrolase (FSH1)
MEANEGAF_00959 2.4e-114 ybhL S Belongs to the BI1 family
MEANEGAF_00960 1.4e-250 mpl 6.3.2.4, 6.3.2.45, 6.3.2.8 M Belongs to the MurCDEF family
MEANEGAF_00961 2e-117 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
MEANEGAF_00962 3.2e-55 ytpP 2.7.1.180, 5.3.4.1 CO Thioredoxin
MEANEGAF_00963 5.1e-59 ytzB S Small secreted protein
MEANEGAF_00964 1.8e-124 trmB 2.1.1.297, 2.1.1.33 J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
MEANEGAF_00965 7.7e-211 ecsB U ABC transporter
MEANEGAF_00966 2.3e-133 ecsA V ABC transporter, ATP-binding protein
MEANEGAF_00967 1.4e-77 hit FG histidine triad
MEANEGAF_00969 3.1e-149 prsA 5.2.1.8 M Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins
MEANEGAF_00970 5.7e-180 yhaM S Metal dependent phosphohydrolases with conserved 'HD' motif.
MEANEGAF_00971 9.8e-56 yheA S Belongs to the UPF0342 family
MEANEGAF_00972 0.0 pbp2A 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
MEANEGAF_00973 0.0 argS 6.1.1.19 J Arginyl-tRNA synthetase
MEANEGAF_00975 1.7e-36
MEANEGAF_00977 5.7e-203 folP 2.5.1.15 H dihydropteroate synthase
MEANEGAF_00978 2.6e-106 xtp 2.5.1.15, 3.6.1.66 F Ham1 family
MEANEGAF_00979 9.8e-244 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
MEANEGAF_00980 4.4e-103 folE 2.7.6.3, 3.5.4.16 F GTP cyclohydrolase 1
MEANEGAF_00981 1.3e-93 folK 1.13.11.81, 2.5.1.15, 2.7.6.3, 3.5.4.16, 4.1.2.25, 5.1.99.8 H 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)
MEANEGAF_00982 8.4e-63 folB 1.13.11.81, 2.5.1.15, 2.7.6.3, 4.1.2.25, 5.1.99.8 H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MEANEGAF_00983 1.5e-118 S CAAX protease self-immunity
MEANEGAF_00984 9.9e-183 rbsR K Periplasmic binding proteins and sugar binding domain of LacI family
MEANEGAF_00985 2e-109
MEANEGAF_00986 8.6e-116 dck 2.7.1.74 F deoxynucleoside kinase
MEANEGAF_00987 3.2e-166 3.2.1.17 NU Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
MEANEGAF_00988 3.5e-255 S Putative peptidoglycan binding domain
MEANEGAF_00989 3.3e-86 uspA T Belongs to the universal stress protein A family
MEANEGAF_00990 9e-275 pepV 3.5.1.18 E dipeptidase PepV
MEANEGAF_00991 4e-156 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MEANEGAF_00992 4.3e-62 3.2.1.23 S Domain of unknown function DUF302
MEANEGAF_00993 1.6e-299 ytgP S Polysaccharide biosynthesis protein
MEANEGAF_00994 9.9e-42
MEANEGAF_00995 0.0 leuS 6.1.1.4 J Belongs to the class-I aminoacyl-tRNA synthetase family
MEANEGAF_00996 1.2e-126 3.1.3.2, 3.1.3.27, 3.1.3.4, 3.1.3.81, 3.6.1.27 I Acid phosphatase homologues
MEANEGAF_00997 3.2e-223 proA 1.2.1.41 E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MEANEGAF_00998 3.7e-140 proB 2.7.2.11 F Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MEANEGAF_00999 1.1e-209 metK 2.5.1.6 H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MEANEGAF_01000 4.5e-52
MEANEGAF_01001 7.2e-28 tag 3.2.2.20 L glycosylase
MEANEGAF_01002 1.7e-252 EGP Major facilitator Superfamily
MEANEGAF_01003 1.6e-84 perR P Belongs to the Fur family
MEANEGAF_01004 2.3e-246 cycA E Amino acid permease
MEANEGAF_01005 4e-22
MEANEGAF_01009 6.9e-116 K Transcriptional regulator, TetR family
MEANEGAF_01010 1.1e-77 hsp O Belongs to the small heat shock protein (HSP20) family
MEANEGAF_01011 1.1e-84 ykhA 3.1.2.20 I Thioesterase superfamily
MEANEGAF_01012 1.5e-64 lytE M LysM domain protein
MEANEGAF_01013 2.8e-196 adh 1.1.1.1, 1.1.1.14 C Zinc-binding dehydrogenase
MEANEGAF_01014 4.6e-236 F Permease
MEANEGAF_01015 5.4e-161 sufD O Uncharacterized protein family (UPF0051)
MEANEGAF_01016 5.3e-112 nrdG 1.97.1.4 O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MEANEGAF_01017 0.0 nrdD 1.1.98.6 F Ribonucleoside-triphosphate reductase
MEANEGAF_01018 2e-110 XK27_05795 P ABC transporter permease
MEANEGAF_01019 2.6e-141 ET Bacterial periplasmic substrate-binding proteins
MEANEGAF_01020 1.3e-11 qacC P COG2076 Membrane transporters of cations and cationic drugs
MEANEGAF_01023 3.7e-16 isp2 L PFAM transposase, IS204 IS1001 IS1096 IS1165 family protein
MEANEGAF_01024 2.1e-35 rpsR J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MEANEGAF_01025 6.4e-91 ssb L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
MEANEGAF_01026 3.6e-48 rpsF J Binds together with S18 to 16S ribosomal RNA
MEANEGAF_01027 0.0 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MEANEGAF_01028 0.0 gyrB 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MEANEGAF_01029 5.6e-203 recF L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MEANEGAF_01030 1.7e-34 yaaA S S4 domain protein YaaA
MEANEGAF_01031 7.2e-206 dnaN 2.7.7.7 L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
MEANEGAF_01032 6.7e-248 dnaA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MEANEGAF_01034 2.6e-14 rpmH J Belongs to the bacterial ribosomal protein bL34 family
MEANEGAF_01035 1.4e-56 rnpA 3.1.26.5 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
MEANEGAF_01036 1.3e-143 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
MEANEGAF_01037 2.4e-145 jag S R3H domain protein
MEANEGAF_01038 2.5e-253 mnmE S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MEANEGAF_01039 0.0 gidA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
MEANEGAF_01040 7e-49 mscL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
MEANEGAF_01041 1.5e-219 lysP E amino acid
MEANEGAF_01042 0.0 asnB 6.3.5.4 E Asparagine synthase
MEANEGAF_01043 8e-293 murE 6.3.2.13, 6.3.2.7 M Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MEANEGAF_01044 1.7e-290 murE 6.3.2.13, 6.3.2.7 M Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MEANEGAF_01045 6.6e-113 lepB 3.4.21.89 U Belongs to the peptidase S26 family
MEANEGAF_01046 8.1e-15 tlpA2 L Transposase IS200 like
MEANEGAF_01047 0.0 pepX 3.4.14.11 E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline
MEANEGAF_01048 1.2e-177 3.4.11.5 E Releases the N-terminal proline from various substrates
MEANEGAF_01049 2.3e-116 gph 3.1.3.18 S HAD hydrolase, family IA, variant
MEANEGAF_01050 8.2e-278 S Uncharacterized protein conserved in bacteria (DUF2325)
MEANEGAF_01051 1.2e-182 1.17.4.1 F Ribonucleotide reductase, small chain
MEANEGAF_01052 2e-169 nrdF 1.17.4.1 F Ribonucleotide reductase, small chain
MEANEGAF_01053 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MEANEGAF_01054 1.4e-83 nrdI F NrdI Flavodoxin like
MEANEGAF_01055 5.1e-110 M ErfK YbiS YcfS YnhG
MEANEGAF_01057 1.8e-206 nrnB S DHHA1 domain
MEANEGAF_01058 3.4e-291 S ABC transporter, ATP-binding protein
MEANEGAF_01059 5.9e-180 ABC-SBP S ABC transporter
MEANEGAF_01060 1e-138 XK27_08840 U Belongs to the binding-protein-dependent transport system permease family
MEANEGAF_01061 1.2e-132 XK27_08845 S ABC transporter, ATP-binding protein
MEANEGAF_01063 5.7e-225 amtB P ammonium transporter
MEANEGAF_01064 8.6e-235 mepA V MATE efflux family protein
MEANEGAF_01065 6.4e-170 scrK 2.7.1.2, 2.7.1.4 GK ROK family
MEANEGAF_01066 1.2e-290 lysS 6.1.1.6 J Belongs to the class-II aminoacyl-tRNA synthetase family
MEANEGAF_01067 1.9e-189 dus J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MEANEGAF_01068 2.6e-163 hslO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MEANEGAF_01069 0.0 ftsH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MEANEGAF_01070 4.1e-98 hpt 2.4.2.8 F Belongs to the purine pyrimidine phosphoribosyltransferase family
MEANEGAF_01071 3.1e-256 tilS 2.4.2.8, 6.3.4.19 J Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
MEANEGAF_01072 3e-87 yabR J RNA binding
MEANEGAF_01073 1.5e-56 divIC D Septum formation initiator
MEANEGAF_01074 1.6e-39 yabO J S4 domain protein
MEANEGAF_01075 0.0 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MEANEGAF_01076 9.6e-103 pth 3.1.1.29 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
MEANEGAF_01077 8.1e-114 S (CBS) domain
MEANEGAF_01078 1.7e-57 L Toxic component of a toxin-antitoxin (TA) module
MEANEGAF_01079 3.6e-210 alr 5.1.1.1 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MEANEGAF_01080 1.1e-59 acpS 2.7.6.3, 2.7.8.7, 5.1.1.1 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
MEANEGAF_01081 5.4e-254 cshA 3.6.4.13 F DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
MEANEGAF_01082 2.1e-260 murF 6.3.2.10, 6.3.2.13 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
MEANEGAF_01083 4.9e-157 htpX O Belongs to the peptidase M48B family
MEANEGAF_01084 4.3e-87 lemA S LemA family
MEANEGAF_01085 4.8e-47 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MEANEGAF_01086 2.3e-122 srtA 3.4.22.70 M sortase family
MEANEGAF_01087 3.9e-07 C Domain of unknown function (DUF4145)
MEANEGAF_01088 3.3e-64
MEANEGAF_01089 4.4e-113 yicL EG EamA-like transporter family
MEANEGAF_01090 2.1e-13 S Domain of unknown function (DUF4352)
MEANEGAF_01091 1.2e-42 S Domain of unknown function (DUF4352)
MEANEGAF_01092 0.0 1.3.5.4 C FAD binding domain
MEANEGAF_01093 3.8e-165 K LysR substrate binding domain
MEANEGAF_01094 7.2e-158 rssA S Phospholipase, patatin family
MEANEGAF_01095 2.5e-214 phbA 2.3.1.9 I Belongs to the thiolase family
MEANEGAF_01096 1.2e-178 S AI-2E family transporter
MEANEGAF_01097 9.1e-125 S membrane transporter protein
MEANEGAF_01098 3.2e-89 pgpA 3.1.3.27 I Phosphatidylglycerophosphatase A
MEANEGAF_01099 2.6e-194 V Beta-lactamase
MEANEGAF_01100 2.3e-226
MEANEGAF_01102 1.8e-153 S Alpha/beta hydrolase of unknown function (DUF915)
MEANEGAF_01103 0.0 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MEANEGAF_01104 2.2e-165 fadB4 1.1.1.157 I 3-hydroxyacyl-CoA dehydrogenase
MEANEGAF_01105 1.3e-162 endA F DNA RNA non-specific endonuclease
MEANEGAF_01106 1.2e-268 pipD E Dipeptidase
MEANEGAF_01108 9.7e-242 gabT 2.6.1.19 E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MEANEGAF_01109 8e-242 yfnA E amino acid
MEANEGAF_01110 3.2e-83 S NADPH-dependent FMN reductase
MEANEGAF_01112 3e-153 L Thioesterase-like superfamily
MEANEGAF_01113 1.4e-50 lacA S transferase hexapeptide repeat
MEANEGAF_01114 4.7e-260 argH 4.3.2.1 E argininosuccinate lyase
MEANEGAF_01115 1.3e-232 argG 6.3.4.5 E Belongs to the argininosuccinate synthase family. Type 1 subfamily
MEANEGAF_01116 1.4e-242 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MEANEGAF_01117 2.7e-64 L Transposase IS200 like
MEANEGAF_01118 1.4e-172 L transposase, IS605 OrfB family
MEANEGAF_01119 0.0 M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MEANEGAF_01120 6.4e-102 K Transcriptional regulator
MEANEGAF_01121 3.4e-23 XK27_06785 V ABC transporter
MEANEGAF_01122 3e-166 M Membrane
MEANEGAF_01123 3.2e-51 S FMN_bind
MEANEGAF_01124 0.0 yhcA V ABC transporter, ATP-binding protein
MEANEGAF_01125 1.4e-116 bm3R1 K Bacterial regulatory proteins, tetR family
MEANEGAF_01126 3.5e-66 mleR K LysR family
MEANEGAF_01127 1.6e-230 sfcA 1.1.1.38, 4.1.1.101 C Malic enzyme
MEANEGAF_01128 5.1e-182 XK27_09615 S reductase
MEANEGAF_01129 1.9e-91 XK27_09620 S NADPH-dependent FMN reductase
MEANEGAF_01130 6.1e-223 fumC 4.2.1.2 C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
MEANEGAF_01131 4.1e-219 frdC 1.3.5.4 C FAD binding domain
MEANEGAF_01132 9.6e-104 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
MEANEGAF_01133 2.2e-50 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
MEANEGAF_01134 4.7e-194 P Sodium:sulfate symporter transmembrane region
MEANEGAF_01135 7.4e-26 P Sodium:sulfate symporter transmembrane region
MEANEGAF_01136 1.2e-174 citR K sugar-binding domain protein
MEANEGAF_01137 8.3e-210 mez_1 1.1.1.38 C Malic enzyme, NAD binding domain
MEANEGAF_01138 2.1e-196 citC 6.2.1.22 H Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
MEANEGAF_01139 5.7e-46 citD C Covalent carrier of the coenzyme of citrate lyase
MEANEGAF_01140 4.2e-164 citE 4.1.3.25, 4.1.3.34 G Belongs to the HpcH HpaI aldolase family
MEANEGAF_01141 2.1e-280 citF 2.8.3.10 H Citrate (pro-3S)-lyase alpha chain
MEANEGAF_01142 2.3e-257 citG 2.4.2.52, 2.7.7.61 H 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase
MEANEGAF_01143 2.9e-145 ydjP I Alpha/beta hydrolase family
MEANEGAF_01144 4.6e-58 gpsB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
MEANEGAF_01145 1e-110 ypsA S Belongs to the UPF0398 family
MEANEGAF_01146 9.9e-112 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
MEANEGAF_01147 0.0 ponA 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein 1A
MEANEGAF_01148 3.7e-160 EG EamA-like transporter family
MEANEGAF_01149 3.1e-192 C Aldo keto reductase family protein
MEANEGAF_01150 1.3e-121 ypuA S Protein of unknown function (DUF1002)
MEANEGAF_01151 8e-134 dnaD L DnaD domain protein
MEANEGAF_01152 2.1e-257 asnS 6.1.1.22 J Asparaginyl-tRNA synthetase
MEANEGAF_01153 1.6e-88 ypmB S Protein conserved in bacteria
MEANEGAF_01154 0.0 dinG 2.7.7.7, 3.6.4.12 L helicase involved in DNA repair and perhaps also replication
MEANEGAF_01155 3.2e-167 mvk 1.1.1.88, 2.3.3.10, 2.7.1.36 I mevalonate kinase
MEANEGAF_01156 5.3e-181 mvaD 4.1.1.33 I diphosphomevalonate decarboxylase
MEANEGAF_01157 1.5e-211 mvaK2 2.7.1.36, 2.7.1.43, 2.7.4.2 I phosphomevalonate kinase
MEANEGAF_01158 9.9e-205 fni 1.1.1.88, 5.3.3.2 C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
MEANEGAF_01159 2.9e-94 pstB 3.6.3.27 L Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
MEANEGAF_01160 2.8e-38 ykuJ S Protein of unknown function (DUF1797)
MEANEGAF_01161 6.5e-182 mprF I Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MEANEGAF_01162 1.5e-199 cpoA GT4 M Glycosyltransferase, group 1 family protein
MEANEGAF_01163 5e-229 mgs 2.4.1.337 GT4 M Glycosyltransferase, group 1 family protein
MEANEGAF_01164 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MEANEGAF_01165 4.7e-39 ptsH G phosphocarrier protein HPR
MEANEGAF_01167 0.0 clpE O Belongs to the ClpA ClpB family
MEANEGAF_01168 6.4e-128 3.6.1.13, 3.6.1.55 F NUDIX domain
MEANEGAF_01169 9.2e-109 pncA Q Isochorismatase family
MEANEGAF_01170 1.7e-265 pncB 6.3.4.21 F Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MEANEGAF_01171 1.7e-97 S Pfam:DUF3816
MEANEGAF_01172 3.6e-142 manA 1.14.13.81, 5.3.1.8, 5.4.2.8 G MucBP domain
MEANEGAF_01173 8.4e-137 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MEANEGAF_01174 5.5e-161 EG EamA-like transporter family
MEANEGAF_01175 1.2e-246 yxbA 6.3.1.12 S ATP-grasp enzyme
MEANEGAF_01176 8.3e-57 acmD 3.2.1.17 NU Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
MEANEGAF_01177 1.1e-59 M repeat protein
MEANEGAF_01178 8.1e-09
MEANEGAF_01179 4.9e-160 yfdH 2.4.2.53 GT2 M Glycosyltransferase, group 2 family protein
MEANEGAF_01180 3e-140 yueF S AI-2E family transporter
MEANEGAF_01181 2.6e-164 ykoT GT2 M Glycosyl transferase family 2
MEANEGAF_01182 2.2e-306 prfC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MEANEGAF_01183 1.3e-95 M transferase activity, transferring glycosyl groups
MEANEGAF_01184 3.1e-103 glfT1 1.1.1.133 S Glycosyltransferase like family 2
MEANEGAF_01185 1.9e-88 S Bacterial membrane protein, YfhO
MEANEGAF_01186 2.5e-172 rfbB 4.2.1.46 M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
MEANEGAF_01187 7.8e-64 gntR1 K Transcriptional regulator, GntR family
MEANEGAF_01188 4.7e-157 V ABC transporter, ATP-binding protein
MEANEGAF_01189 1.2e-14
MEANEGAF_01190 1.1e-49 K TRANSCRIPTIONal
MEANEGAF_01191 1.9e-261 rumA 2.1.1.190 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MEANEGAF_01192 1.9e-186 yegS 2.7.1.107 G Lipid kinase
MEANEGAF_01193 1.5e-272 gatB 6.1.1.12, 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MEANEGAF_01194 6.3e-271 gatA 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
MEANEGAF_01195 4.3e-47 gatC 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MEANEGAF_01196 4.8e-162 camS S sex pheromone
MEANEGAF_01197 0.0 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MEANEGAF_01198 0.0 pcrA 3.6.4.12 L ATP-dependent DNA helicase
MEANEGAF_01199 3.1e-220 purK2 6.3.4.18 F Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
MEANEGAF_01200 3.2e-101 xpt 2.4.2.22, 2.4.2.7 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
MEANEGAF_01201 5.8e-109 acmC 3.2.1.17, 3.2.1.96 NU mannosyl-glycoprotein
MEANEGAF_01202 4.4e-138 IQ reductase
MEANEGAF_01203 1.2e-111 nss M transferase activity, transferring glycosyl groups
MEANEGAF_01204 1.3e-88 secY2 U SecY translocase
MEANEGAF_01205 1.8e-103 asp1 S Accessory Sec system protein Asp1
MEANEGAF_01206 1.4e-130 asp2 3.4.11.5 S Accessory Sec system GspB-transporter
MEANEGAF_01207 1.9e-19 asp3 S Accessory Sec secretory system ASP3
MEANEGAF_01208 6.4e-273 secA2 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
MEANEGAF_01210 4.3e-166 gtf1 2.4.1.52 GT4 M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
MEANEGAF_01211 2e-130 gtf2 M A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1
MEANEGAF_01212 4.6e-115 yecS E ABC transporter permease
MEANEGAF_01213 1e-156 yckB ET Belongs to the bacterial solute-binding protein 3 family
MEANEGAF_01214 6.5e-105 XK27_02070 S Nitroreductase family
MEANEGAF_01215 8e-67 rnhA 3.1.26.4 L Ribonuclease HI
MEANEGAF_01216 1.7e-70 esbA S Family of unknown function (DUF5322)
MEANEGAF_01217 1.5e-74 lspA 3.4.23.36 MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MEANEGAF_01218 3.5e-171 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
MEANEGAF_01219 2e-205 carA 6.3.5.5 F Belongs to the CarA family
MEANEGAF_01220 0.0 carB 6.3.5.5 F Carbamoyl-phosphate synthase
MEANEGAF_01221 1.7e-119 cah 4.2.1.1 P Eukaryotic-type carbonic anhydrase
MEANEGAF_01222 6.7e-30 akr5f S reductase
MEANEGAF_01223 4.2e-28 akr5f 1.1.1.346 S reductase
MEANEGAF_01224 6.7e-42 S Bacterial transferase hexapeptide (six repeats)
MEANEGAF_01225 1.4e-47 C Flavodoxin
MEANEGAF_01226 4.6e-100 P nitric oxide dioxygenase activity
MEANEGAF_01227 0.0 FbpA K Fibronectin-binding protein
MEANEGAF_01228 1.6e-160 degV S EDD domain protein, DegV family
MEANEGAF_01229 3.9e-97
MEANEGAF_01230 4.8e-134 S Belongs to the UPF0246 family
MEANEGAF_01231 1.5e-118 ypgQ S Metal dependent phosphohydrolases with conserved 'HD' motif.
MEANEGAF_01232 5.3e-113 ylbE GM NAD(P)H-binding
MEANEGAF_01233 3.5e-99 K Acetyltransferase (GNAT) domain
MEANEGAF_01234 8.8e-156 thrB 2.7.1.39 F Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
MEANEGAF_01235 5.9e-233 hom 1.1.1.3, 2.7.2.4 E homoserine dehydrogenase
MEANEGAF_01236 6.7e-284 thrC 4.2.3.1 E Threonine synthase
MEANEGAF_01237 6.1e-123 azlC E azaleucine resistance protein AzlC
MEANEGAF_01238 2.8e-54 azlD E Branched-chain amino acid transport
MEANEGAF_01239 1.6e-54 yphJ 4.1.1.44 S decarboxylase
MEANEGAF_01240 4.8e-183 pdhA 1.2.4.1, 1.2.4.4 C Dehydrogenase E1 component
MEANEGAF_01241 1.3e-179 pdhB 1.2.4.1 C Transketolase, C-terminal domain protein
MEANEGAF_01242 4.5e-204 pdhC 2.3.1.12 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
MEANEGAF_01243 3.1e-259 lpdA 1.8.1.4 C Dehydrogenase
MEANEGAF_01244 2.5e-194 lplA 6.3.1.20 H Lipoate-protein ligase
MEANEGAF_01245 1.2e-216 E GDSL-like Lipase/Acylhydrolase family
MEANEGAF_01246 7.5e-16 K LysR substrate binding domain protein
MEANEGAF_01247 7.6e-70 K LysR substrate binding domain protein
MEANEGAF_01248 2.5e-212 naiP EGP Major facilitator Superfamily
MEANEGAF_01249 2e-250 yhdP S Transporter associated domain
MEANEGAF_01250 1.1e-199 mdtG EGP Major facilitator Superfamily
MEANEGAF_01251 5.6e-160 EGP Major facilitator Superfamily
MEANEGAF_01252 4.5e-168 T Calcineurin-like phosphoesterase superfamily domain
MEANEGAF_01253 5.4e-43 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MEANEGAF_01254 2.9e-235 pts13C G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
MEANEGAF_01255 4.7e-152 S Alpha/beta hydrolase of unknown function (DUF915)
MEANEGAF_01256 6.9e-275 pipD E Dipeptidase
MEANEGAF_01257 0.0 yjbQ P TrkA C-terminal domain protein
MEANEGAF_01258 5.4e-26 dmpI 5.3.2.6 G Belongs to the 4-oxalocrotonate tautomerase family
MEANEGAF_01259 1.7e-282 glpK 2.7.1.30 F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MEANEGAF_01261 0.0 kup P Transport of potassium into the cell
MEANEGAF_01262 1.6e-49
MEANEGAF_01263 0.0 S Bacterial membrane protein YfhO
MEANEGAF_01265 4.2e-235 lmrB EGP Major facilitator Superfamily
MEANEGAF_01266 1.4e-156 S Alpha beta hydrolase
MEANEGAF_01267 2.5e-158 1.6.5.2 GM NAD(P)H-binding
MEANEGAF_01268 1.7e-153 S Sucrose-6F-phosphate phosphohydrolase
MEANEGAF_01270 4.1e-241 dtpT U amino acid peptide transporter
MEANEGAF_01272 2.1e-211 ydiN G Major Facilitator Superfamily
MEANEGAF_01273 7.6e-13 pheA 1.3.1.12, 2.3.1.79, 4.2.1.51, 5.4.99.5 E Chorismate mutase type II
MEANEGAF_01274 1.2e-61 aroC 4.2.3.5 E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MEANEGAF_01275 1.8e-142 aroC 4.2.3.5 E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MEANEGAF_01276 1.3e-196 tyrA 1.3.1.12, 1.3.1.43 E prephenate dehydrogenase
MEANEGAF_01277 8.7e-90 aroK 1.1.1.25, 2.7.1.71, 4.2.1.10, 4.2.3.4 F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MEANEGAF_01278 1.7e-215 aspB E DegT/DnrJ/EryC1/StrS aminotransferase family
MEANEGAF_01279 2.5e-183 1.1.1.28 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MEANEGAF_01280 2.5e-178 hepT 2.5.1.30, 2.5.1.90 H Belongs to the FPP GGPP synthase family
MEANEGAF_01281 2.7e-155 menA 2.5.1.74 H 1,4-dihydroxy-2-naphthoate
MEANEGAF_01282 6.7e-23 S Virus attachment protein p12 family
MEANEGAF_01283 0.0 feoB P transporter of a GTP-driven Fe(2 ) uptake system
MEANEGAF_01284 3.9e-33 feoA P FeoA domain
MEANEGAF_01285 3.6e-143 sufC O FeS assembly ATPase SufC
MEANEGAF_01286 5.8e-244 sufD O FeS assembly protein SufD
MEANEGAF_01287 1.8e-234 sufS 2.8.1.7, 4.4.1.16 E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MEANEGAF_01288 3.2e-83 nifU C SUF system FeS assembly protein, NifU family
MEANEGAF_01289 4.2e-272 sufB O assembly protein SufB
MEANEGAF_01290 7.8e-178 fecB P Periplasmic binding protein
MEANEGAF_01291 2.9e-162 F DNA/RNA non-specific endonuclease
MEANEGAF_01292 1.8e-70 L nuclease
MEANEGAF_01293 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MEANEGAF_01294 5.9e-22
MEANEGAF_01295 4.3e-183 L PFAM Integrase catalytic region
MEANEGAF_01296 2e-278 mntH P H( )-stimulated, divalent metal cation uptake system
MEANEGAF_01297 9.3e-189 tdh 1.1.1.14 E Alcohol dehydrogenase GroES-like domain
MEANEGAF_01298 3.1e-107 ygfC K Bacterial regulatory proteins, tetR family
MEANEGAF_01299 3.9e-158 hrtB V ABC transporter permease
MEANEGAF_01300 6.1e-123 devA 3.6.3.25 V ABC transporter, ATP-binding protein
MEANEGAF_01301 7e-75 argR K Regulates arginine biosynthesis genes
MEANEGAF_01302 2.6e-46 czrA K Transcriptional regulator, ArsR family
MEANEGAF_01303 2.2e-139 acm2 3.2.1.17 NU Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
MEANEGAF_01304 3e-26 L Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
MEANEGAF_01307 2.1e-258 nylA 3.5.1.4 J Belongs to the amidase family
MEANEGAF_01308 1.5e-203 arcD S C4-dicarboxylate anaerobic carrier
MEANEGAF_01309 1.1e-192 ytjP 3.5.1.18 E Dipeptidase
MEANEGAF_01310 1.4e-214 rlmL 2.1.1.173, 2.1.1.264 L Belongs to the methyltransferase superfamily
MEANEGAF_01311 8.9e-83 F Hydrolase, NUDIX family
MEANEGAF_01312 1.5e-211 S Type IV secretion-system coupling protein DNA-binding domain
MEANEGAF_01313 1.6e-77 S Phage terminase, large subunit
MEANEGAF_01314 1.2e-45 L Terminase small subunit
MEANEGAF_01315 1.6e-20 U Preprotein translocase subunit SecB
MEANEGAF_01319 3.5e-48 S Motility quorum-sensing regulator, toxin of MqsA
MEANEGAF_01320 8.3e-168 ps301 K Protein of unknown function (DUF4065)
MEANEGAF_01322 9e-57 sprF M Cell surface antigen C-terminus
MEANEGAF_01324 3e-15 hicB S HicB family
MEANEGAF_01325 5.5e-57 ydiI Q Thioesterase superfamily
MEANEGAF_01326 5.3e-158 menB 4.1.3.36 H Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MEANEGAF_01327 3.4e-277 menE 6.2.1.26 H Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily
MEANEGAF_01328 1.7e-218 G Transporter, major facilitator family protein
MEANEGAF_01329 1.6e-207 adh 1.1.1.1, 1.1.1.14 C Zinc-binding dehydrogenase
MEANEGAF_01330 5.2e-212 metC 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
MEANEGAF_01331 4.8e-168 mccA 2.5.1.134, 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
MEANEGAF_01332 2.5e-40 gcvR T Belongs to the UPF0237 family
MEANEGAF_01333 1.8e-243 XK27_08635 S UPF0210 protein
MEANEGAF_01334 2.8e-179 yobV1 K WYL domain
MEANEGAF_01335 1.6e-67 S pyridoxamine 5-phosphate
MEANEGAF_01336 6.3e-34
MEANEGAF_01337 1.4e-158 xth 3.1.11.2 L exodeoxyribonuclease III
MEANEGAF_01338 8.5e-56
MEANEGAF_01341 2.2e-235 kgtP EGP Sugar (and other) transporter
MEANEGAF_01342 5.4e-141 fhuC 3.6.3.34 HP ABC transporter, ATP-binding protein
MEANEGAF_01343 7.5e-153 isdF U Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MEANEGAF_01344 2.8e-149 isdE P Periplasmic binding protein
MEANEGAF_01345 6.8e-94 M Iron Transport-associated domain
MEANEGAF_01346 3.7e-284 isdH M Iron Transport-associated domain
MEANEGAF_01347 2.8e-51
MEANEGAF_01348 3.2e-53 4.1.1.44 O Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MEANEGAF_01349 7.5e-103 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
MEANEGAF_01350 2.4e-49 yktA S Belongs to the UPF0223 family
MEANEGAF_01351 4.8e-137 suhB 3.1.3.25 G Belongs to the inositol monophosphatase superfamily
MEANEGAF_01352 0.0 typA T GTP-binding protein TypA
MEANEGAF_01353 6.2e-216 ftsW D Belongs to the SEDS family
MEANEGAF_01354 1.4e-47 ylbG S Uncharacterized protein conserved in bacteria (DUF2129)
MEANEGAF_01355 1.3e-99 rsmD 2.1.1.171 L RNA methyltransferase, RsmD family
MEANEGAF_01356 9.6e-89 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MEANEGAF_01357 6.7e-198 ylbL T Belongs to the peptidase S16 family
MEANEGAF_01358 1.3e-90 comEA L Competence protein ComEA
MEANEGAF_01359 3.4e-88 comEB 3.5.4.12 F ComE operon protein 2
MEANEGAF_01360 0.0 comEC S Competence protein ComEC
MEANEGAF_01362 3.4e-26 L Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
MEANEGAF_01363 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MEANEGAF_01364 1e-243 fucP G Major Facilitator Superfamily
MEANEGAF_01365 2.1e-67 rbsD 5.4.99.62 G Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose
MEANEGAF_01366 2.2e-165 rbsK 2.7.1.15 H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MEANEGAF_01367 3.2e-170 deoR K sugar-binding domain protein
MEANEGAF_01368 4.9e-114 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MEANEGAF_01369 5.8e-199 S Domain of unknown function (DUF4432)
MEANEGAF_01370 1.2e-174 rbsK 2.7.1.15 H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MEANEGAF_01371 1.7e-260 G PTS system Galactitol-specific IIC component
MEANEGAF_01372 1.1e-169 K helix_turn _helix lactose operon repressor
MEANEGAF_01373 1.4e-76 cylA V abc transporter atp-binding protein
MEANEGAF_01374 3.1e-60 cylB V ABC-2 type transporter
MEANEGAF_01375 7e-27 K LytTr DNA-binding domain
MEANEGAF_01376 4.8e-11 S Protein of unknown function (DUF3021)
MEANEGAF_01378 5.1e-89
MEANEGAF_01379 3.2e-77 F Nucleoside 2-deoxyribosyltransferase
MEANEGAF_01380 1.8e-181 scrR3 K Transcriptional regulator, LacI family
MEANEGAF_01381 3e-14
MEANEGAF_01382 1.7e-17 hbd2 1.1.1.157 I 3-hydroxyacyl-CoA dehydrogenase
MEANEGAF_01383 0.0 asnB 6.3.5.4 E Aluminium induced protein
MEANEGAF_01385 9.9e-08 S Bacterial transferase hexapeptide (six repeats)
MEANEGAF_01386 1.3e-117 IQ Enoyl-(Acyl carrier protein) reductase
MEANEGAF_01387 1.6e-199 gldA 1.1.1.6 C dehydrogenase
MEANEGAF_01388 9e-16 XK27_01125 L PFAM IS66 Orf2 family protein
MEANEGAF_01389 9e-291 norB EGP Major Facilitator
MEANEGAF_01390 2.1e-97 K Bacterial regulatory proteins, tetR family
MEANEGAF_01391 1.6e-58 L Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed
MEANEGAF_01392 4e-65
MEANEGAF_01393 6.8e-53
MEANEGAF_01394 6.3e-216 S Domain of unknown function (DUF389)
MEANEGAF_01395 1.1e-234 yagE E Amino acid permease
MEANEGAF_01396 1.3e-130 tnp L DDE domain
MEANEGAF_01397 2.7e-252 G Major Facilitator Superfamily
MEANEGAF_01398 0.0 nplT 3.2.1.133, 3.2.1.135, 3.2.1.54 GH13 G Belongs to the glycosyl hydrolase 13 family
MEANEGAF_01401 2.1e-146 clpB O Belongs to the ClpA ClpB family
MEANEGAF_01405 5.8e-161 topA2 5.99.1.2 G Topoisomerase IA
MEANEGAF_01406 1.5e-50 L Protein of unknown function (DUF3991)
MEANEGAF_01407 1.3e-09 grxC O glutaredoxin-like protein, YruB-family
MEANEGAF_01408 3.7e-07 K Helix-turn-helix domain
MEANEGAF_01410 7.7e-59 fic D Fic/DOC family
MEANEGAF_01411 3.1e-21
MEANEGAF_01412 3.8e-16 E Zn peptidase
MEANEGAF_01413 1e-14 3.4.21.88 K Helix-turn-helix
MEANEGAF_01414 2.5e-07 cro K Helix-turn-helix XRE-family like proteins
MEANEGAF_01415 5.4e-120 K Phage regulatory protein
MEANEGAF_01417 5e-11
MEANEGAF_01421 1.3e-107 recT L RecT family
MEANEGAF_01422 2.9e-111 S PDDEXK-like domain of unknown function (DUF3799)
MEANEGAF_01423 6.9e-95 ssb_2 L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
MEANEGAF_01424 9e-26 L Psort location Cytoplasmic, score
MEANEGAF_01429 1.3e-42
MEANEGAF_01430 2e-78 L Phage terminase, small subunit
MEANEGAF_01431 0.0 S Phage Terminase
MEANEGAF_01433 9.4e-217 S Phage portal protein
MEANEGAF_01434 1e-174 G Phage capsid family
MEANEGAF_01435 1.1e-47
MEANEGAF_01436 1.4e-14 S Phage head-tail joining protein
MEANEGAF_01437 4.1e-32 S Bacteriophage HK97-gp10, putative tail-component
MEANEGAF_01438 1.1e-17 S Protein of unknown function (DUF806)
MEANEGAF_01439 4.2e-115 S Phage tail tube protein
MEANEGAF_01440 2e-52 S Phage tail assembly chaperone proteins, TAC
MEANEGAF_01441 0.0 M Phage tail tape measure protein TP901
MEANEGAF_01442 1.9e-163 S Phage tail protein
MEANEGAF_01443 1.8e-305 ydhO 3.4.14.13 M Prophage endopeptidase tail
MEANEGAF_01444 1.5e-78 spoIVFA GT2,GT4 D peptidase
MEANEGAF_01452 5.6e-17 S Bacteriophage holin of superfamily 6 (Holin_LLH)
MEANEGAF_01453 3.7e-91 M Glycosyl hydrolases family 25
MEANEGAF_01455 9.6e-115 K Transcriptional regulator
MEANEGAF_01456 5.2e-50 rplU J This protein binds to 23S rRNA in the presence of protein L20
MEANEGAF_01457 9e-53 ysxB J Cysteine protease Prp
MEANEGAF_01458 7.1e-46 rpmA J Belongs to the bacterial ribosomal protein bL27 family
MEANEGAF_01459 2.9e-204 pepP 3.4.11.9, 3.4.13.9 E Creatinase/Prolidase N-terminal domain
MEANEGAF_01460 4.1e-72 yqhY S Asp23 family, cell envelope-related function
MEANEGAF_01461 8.9e-69 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MEANEGAF_01462 2.6e-160 folD 1.5.1.5, 3.5.4.9 F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MEANEGAF_01463 2.3e-257 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
MEANEGAF_01464 1e-18 xseB 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
MEANEGAF_01465 3.6e-157 ispA 2.5.1.1, 2.5.1.10, 2.5.1.29, 2.5.1.90 H Belongs to the FPP GGPP synthase family
MEANEGAF_01466 1.6e-146 rrmJ 2.1.1.226, 2.1.1.227 J Ribosomal RNA large subunit methyltransferase J
MEANEGAF_01467 1.4e-75 argR K Regulates arginine biosynthesis genes
MEANEGAF_01468 1.3e-307 recN L May be involved in recombinational repair of damaged DNA
MEANEGAF_01469 2.5e-15
MEANEGAF_01470 3.9e-113 gmk 2.7.4.8 F Essential for recycling GMP and indirectly, cGMP
MEANEGAF_01471 3.2e-46 rpoZ 2.7.7.6 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
MEANEGAF_01472 5.4e-215 coaBC 4.1.1.36, 6.3.2.5 H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MEANEGAF_01473 0.0 priA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MEANEGAF_01474 2.7e-174 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MEANEGAF_01475 1e-246 sun 2.1.1.176 J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MEANEGAF_01476 2.2e-131 stp 3.1.3.16 T phosphatase
MEANEGAF_01477 0.0 KLT serine threonine protein kinase
MEANEGAF_01478 1.7e-165 rsgA 3.1.3.100 S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
MEANEGAF_01479 1.1e-118 rpe 5.1.3.1 G Belongs to the ribulose-phosphate 3-epimerase family
MEANEGAF_01480 1.2e-123 thiN 2.7.6.2 H thiamine pyrophosphokinase
MEANEGAF_01481 7.2e-26 rpmB J Belongs to the bacterial ribosomal protein bL28 family
MEANEGAF_01482 3.6e-58 asp S Asp23 family, cell envelope-related function
MEANEGAF_01483 2.9e-304 yloV S DAK2 domain fusion protein YloV
MEANEGAF_01484 0.0 recG 3.6.4.12 L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MEANEGAF_01485 4.8e-164 plsX 2.3.1.15 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
MEANEGAF_01486 4.5e-36 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
MEANEGAF_01487 1.2e-129 rnc 3.1.26.3 J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
MEANEGAF_01488 0.0 smc D Required for chromosome condensation and partitioning
MEANEGAF_01489 7.2e-180 ftsY U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
MEANEGAF_01490 3.7e-57 ylxM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
MEANEGAF_01491 1.7e-244 ffh 3.6.5.4 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MEANEGAF_01493 4.2e-96
MEANEGAF_01494 2.6e-129 K Transcriptional regulatory protein, C-terminal domain protein
MEANEGAF_01495 5.1e-159 pstS P Phosphate
MEANEGAF_01496 1.9e-153 pstC P probably responsible for the translocation of the substrate across the membrane
MEANEGAF_01497 5.5e-153 pstA P Phosphate transport system permease protein PstA
MEANEGAF_01498 6.8e-136 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
MEANEGAF_01499 1.1e-122 phoU P Plays a role in the regulation of phosphate uptake
MEANEGAF_01500 2.9e-44 rpsP J Belongs to the bacterial ribosomal protein bS16 family
MEANEGAF_01501 1e-38 ylqC S Belongs to the UPF0109 family
MEANEGAF_01502 8e-88 rimM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MEANEGAF_01503 2.9e-142 trmD 2.1.1.228, 4.6.1.12 J Belongs to the RNA methyltransferase TrmD family
MEANEGAF_01504 3.7e-260 yfnA E Amino Acid
MEANEGAF_01505 2.1e-58 rplS J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
MEANEGAF_01506 1.7e-252 cas3 L CRISPR-associated helicase cas3
MEANEGAF_01507 1e-155 casA L the current gene model (or a revised gene model) may contain a frame shift
MEANEGAF_01508 1.9e-40 casB S CRISPR-associated protein Cse2 (CRISPR_cse2)
MEANEGAF_01509 1.8e-129 casC L CT1975-like protein
MEANEGAF_01510 1.8e-66 casD S CRISPR-associated protein (Cas_Cas5)
MEANEGAF_01511 1.5e-32 casE S CRISPR_assoc
MEANEGAF_01512 7.9e-126 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MEANEGAF_01513 3.6e-80 cas2 2.7.7.7 L CRISPR-associated protein (Cas_Cas2CT1978)
MEANEGAF_01514 1e-103 dedA S SNARE-like domain protein
MEANEGAF_01515 1.3e-24 S Protein of unknown function (DUF1461)
MEANEGAF_01516 1.5e-141 nagD 2.7.1.25, 3.1.3.41 G Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
MEANEGAF_01517 3.4e-97 yutD S Protein of unknown function (DUF1027)
MEANEGAF_01518 5.3e-110 S Calcineurin-like phosphoesterase
MEANEGAF_01519 1.1e-223 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MEANEGAF_01520 8.6e-159 ytxK 2.1.1.72 L N-6 DNA Methylase
MEANEGAF_01522 1e-14
MEANEGAF_01524 2.3e-15 NU general secretion pathway protein
MEANEGAF_01525 1.1e-47 comGC U competence protein ComGC
MEANEGAF_01526 2.1e-159 comGB NU type II secretion system
MEANEGAF_01527 7e-178 comGA NU Type II IV secretion system protein
MEANEGAF_01528 2.6e-155 ykcB M Dolichyl-phosphate-mannose-protein mannosyltransferase
MEANEGAF_01529 2e-106 tnp L MULE transposase domain
MEANEGAF_01530 5.3e-272 rsmF 2.1.1.176, 2.1.1.178 J NOL1 NOP2 sun family protein
MEANEGAF_01531 1.1e-152 yitU 3.1.3.104 S hydrolase
MEANEGAF_01532 3.1e-167 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
MEANEGAF_01533 0.0 carB 6.3.5.5 F Carbamoyl-phosphate synthase
MEANEGAF_01534 8.7e-209 carA 6.3.5.5 F Carbamoyl-phosphate synthetase glutamine chain
MEANEGAF_01535 4e-245 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
MEANEGAF_01536 3.6e-182 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
MEANEGAF_01537 6.5e-113 ycsI S Protein of unknown function (DUF1445)
MEANEGAF_01538 3.1e-206 yfnA E Amino Acid
MEANEGAF_01539 1.3e-72 apfA 2.7.7.72, 3.6.1.61 F Nudix hydrolase
MEANEGAF_01540 1.3e-105 gmk2 2.7.4.8 F Guanylate kinase
MEANEGAF_01541 4e-83 zur P Belongs to the Fur family
MEANEGAF_01543 6.3e-168
MEANEGAF_01544 1.1e-187 galM 5.1.3.3 G Catalyzes the interconversion of alpha and beta anomers of maltose
MEANEGAF_01545 2.3e-93 K Transcriptional regulator (TetR family)
MEANEGAF_01546 7.1e-204 V domain protein
MEANEGAF_01547 2e-140 L An automated process has identified a potential problem with this gene model
MEANEGAF_01548 2e-80 K FR47-like protein
MEANEGAF_01549 2e-37 tra L Transposase and inactivated derivatives, IS30 family
MEANEGAF_01550 2e-169 L Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
MEANEGAF_01551 8.3e-81
MEANEGAF_01552 0.0 cadA 3.6.3.3, 3.6.3.5 P E1-E2 ATPase
MEANEGAF_01553 5.6e-33 copZ P Heavy-metal-associated domain
MEANEGAF_01554 5.4e-46 D Di-iron-containing protein involved in the repair of iron-sulfur clusters
MEANEGAF_01555 4.1e-113 flp 4.1.99.16, 4.2.3.22, 4.2.3.75 K Transcriptional regulator, Crp Fnr family
MEANEGAF_01556 6.2e-85 L hmm pf00665
MEANEGAF_01557 8.3e-51 L Helix-turn-helix domain
MEANEGAF_01558 6.4e-90 L Transposase
MEANEGAF_01559 1.9e-136 L Transposase and inactivated derivatives, IS30 family
MEANEGAF_01571 2.4e-95 res L Domain of unknown function (DUF3427)
MEANEGAF_01575 1.5e-14 S Conserved phage C-terminus (Phg_2220_C)
MEANEGAF_01576 4.5e-07 C Domain of unknown function (DUF4145)
MEANEGAF_01577 2.6e-180 1.1.1.26 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MEANEGAF_01578 1.3e-25 pucG 2.6.1.112, 2.6.1.44, 2.6.1.45, 2.6.1.51 E Aminotransferase class-V
MEANEGAF_01579 2.1e-26 pucG 2.6.1.112, 2.6.1.44, 2.6.1.45, 2.6.1.51 E Aminotransferase class-V
MEANEGAF_01580 7.5e-69 pucG 2.6.1.112, 2.6.1.44, 2.6.1.45, 2.6.1.51 E Aminotransferase class-V
MEANEGAF_01581 3.6e-40 sucD 6.2.1.5 C Protein of unknown function (DUF1116)
MEANEGAF_01584 2e-121 arcC 2.7.2.2 E Amino acid kinase family
MEANEGAF_01585 9.3e-175 rihA 3.2.2.1 F Inosine-uridine preferring nucleoside hydrolase
MEANEGAF_01586 3e-124 C nitroreductase
MEANEGAF_01587 4.6e-137 E GDSL-like Lipase/Acylhydrolase family
MEANEGAF_01588 2.3e-53 S Mazg nucleotide pyrophosphohydrolase
MEANEGAF_01589 1.9e-90 P Cadmium resistance transporter
MEANEGAF_01590 2.7e-97 C aldo keto reductase
MEANEGAF_01591 1.3e-19 S Uncharacterized protein conserved in bacteria (DUF2255)
MEANEGAF_01593 9.4e-25 C Aldo keto reductase
MEANEGAF_01594 3.4e-40 C Aldo keto reductase
MEANEGAF_01595 2.9e-79 S Belongs to the short-chain dehydrogenases reductases (SDR) family
MEANEGAF_01596 2.4e-83 S Alpha/beta hydrolase family
MEANEGAF_01597 3e-119 pnb C nitroreductase
MEANEGAF_01598 4.1e-09 flpA 4.1.99.16, 4.2.3.22, 4.2.3.75 K helix_turn_helix, cAMP Regulatory protein
MEANEGAF_01599 5.4e-44 S Tautomerase enzyme
MEANEGAF_01600 4.7e-29 S Domain of unknown function (DUF4767)
MEANEGAF_01601 7.8e-09
MEANEGAF_01602 2.8e-67 uvrX 2.7.7.7 L Belongs to the DNA polymerase type-Y family
MEANEGAF_01603 1.7e-41 uvrX 2.7.7.7 L Belongs to the DNA polymerase type-Y family
MEANEGAF_01604 9.4e-178 K Transcriptional regulator, LacI family
MEANEGAF_01605 0.0 malL 3.2.1.10 GH13 G Alpha amylase, catalytic domain protein
MEANEGAF_01606 9.2e-253 G Major Facilitator
MEANEGAF_01607 9.7e-23 D Alpha beta
MEANEGAF_01608 2e-24 D Alpha beta
MEANEGAF_01609 4.9e-52 ypaA S Protein of unknown function (DUF1304)
MEANEGAF_01611 3e-189 panE1 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MEANEGAF_01612 0.0 uvrA2 L ABC transporter
MEANEGAF_01613 4.3e-103 tag 3.2.2.20 L Methyladenine glycosylase
MEANEGAF_01614 8.8e-235 stp_1 EGP Major facilitator Superfamily
MEANEGAF_01615 8.9e-60 MA20_41110 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MEANEGAF_01616 1.8e-113 H ThiF family
MEANEGAF_01617 2e-205 arsR K helix_turn_helix, Arsenical Resistance Operon Repressor
MEANEGAF_01618 3.6e-28 L Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
MEANEGAF_01619 1.5e-65 rpsI J Belongs to the universal ribosomal protein uS9 family
MEANEGAF_01620 2.6e-79 rplM J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MEANEGAF_01621 2.2e-145 truA 5.4.99.12 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
MEANEGAF_01622 1.4e-139 ecfT U Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MEANEGAF_01623 2e-155 ecfA2 3.6.3.55 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MEANEGAF_01624 7.8e-149 cbiO P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MEANEGAF_01625 2.8e-61 rplQ J Ribosomal protein L17
MEANEGAF_01626 2e-169 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MEANEGAF_01627 1e-63 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MEANEGAF_01628 9.5e-59 rpsM J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MEANEGAF_01629 1.1e-13 rpmJ J Belongs to the bacterial ribosomal protein bL36 family
MEANEGAF_01630 2e-32 infA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MEANEGAF_01631 6.4e-122 adk 2.7.4.3 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
MEANEGAF_01632 5.8e-236 secY U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
MEANEGAF_01633 2.1e-65 rplO J Binds to the 23S rRNA
MEANEGAF_01634 2.5e-23 rpmD J Ribosomal protein L30
MEANEGAF_01635 2.6e-86 rpsE J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MEANEGAF_01636 3.9e-57 rplR J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MEANEGAF_01637 5.1e-93 rplF J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MEANEGAF_01638 1e-66 rpsH J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MEANEGAF_01639 5.2e-29 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MEANEGAF_01640 4.2e-95 rplE J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MEANEGAF_01641 5.2e-50 rplX J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MEANEGAF_01642 6.6e-60 rplN J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MEANEGAF_01643 6.5e-41 rpsQ J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MEANEGAF_01644 1.1e-27 rpmC J Belongs to the universal ribosomal protein uL29 family
MEANEGAF_01645 6e-76 rplP J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MEANEGAF_01646 6.2e-117 rpsC J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MEANEGAF_01647 2.2e-52 rplV J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MEANEGAF_01648 8.4e-47 rpsS J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MEANEGAF_01649 3.2e-150 rplB J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MEANEGAF_01650 4.8e-45 rplW J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
MEANEGAF_01651 2.7e-106 rplD J Forms part of the polypeptide exit tunnel
MEANEGAF_01652 8.7e-119 rplC J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MEANEGAF_01653 2.6e-49 rpsJ J Involved in the binding of tRNA to the ribosomes
MEANEGAF_01654 0.0 fusA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MEANEGAF_01655 7.1e-83 rpsG J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
MEANEGAF_01656 3.2e-71 rpsL J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MEANEGAF_01657 2.1e-32 pilD 3.4.23.43 NOU aspartic-type endopeptidase activity
MEANEGAF_01658 2.2e-213 ykiI
MEANEGAF_01659 5.6e-135 puuD S peptidase C26
MEANEGAF_01660 0.0 rpoC 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MEANEGAF_01661 0.0 rpoB 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MEANEGAF_01662 5.8e-106 K Bacterial regulatory proteins, tetR family
MEANEGAF_01663 0.0 clpC O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
MEANEGAF_01664 4.8e-79 ctsR K Belongs to the CtsR family
MEANEGAF_01665 9.7e-194 adhP 1.1.1.1 C alcohol dehydrogenase
MEANEGAF_01666 1.3e-131 XK27_07210 6.1.1.6 S B3 4 domain
MEANEGAF_01667 1e-119 J 2'-5' RNA ligase superfamily
MEANEGAF_01669 1.8e-53 S ABC-type cobalt transport system, permease component
MEANEGAF_01670 1.1e-147 uppP 3.6.1.27 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
MEANEGAF_01671 1.3e-45 IQ reductase
MEANEGAF_01672 1e-10 IQ Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MEANEGAF_01678 3.9e-116 dak 2.7.1.74, 2.7.1.76 F deoxynucleoside kinase
MEANEGAF_01679 3.9e-268 lysP E amino acid
MEANEGAF_01681 8.3e-156 I alpha/beta hydrolase fold
MEANEGAF_01682 9.1e-116 lssY 3.6.1.27 I phosphatase
MEANEGAF_01683 2.8e-82 S Threonine/Serine exporter, ThrE
MEANEGAF_01684 1.2e-124 thrE S Putative threonine/serine exporter
MEANEGAF_01685 2.8e-28 cspA K Cold shock protein
MEANEGAF_01686 5.9e-123 sirR K iron dependent repressor
MEANEGAF_01687 4.6e-163 czcD P cation diffusion facilitator family transporter
MEANEGAF_01688 2.5e-116 S membrane
MEANEGAF_01689 7.6e-110 S VIT family
MEANEGAF_01690 4.5e-85 usp1 T Belongs to the universal stress protein A family
MEANEGAF_01691 8.1e-33 elaA S GNAT family
MEANEGAF_01692 1.4e-215 S CAAX protease self-immunity
MEANEGAF_01693 0.0 rnjA J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MEANEGAF_01694 1.5e-58
MEANEGAF_01695 1.9e-74 merR K MerR HTH family regulatory protein
MEANEGAF_01696 4.3e-267 lmrB EGP Major facilitator Superfamily
MEANEGAF_01697 2.4e-114 S Domain of unknown function (DUF4811)
MEANEGAF_01698 9.4e-149 araA 5.3.1.4 G Catalyzes the conversion of L-arabinose to L-ribulose
MEANEGAF_01699 9e-172 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 J Responsible for synthesis of pseudouridine from uracil
MEANEGAF_01701 0.0 mprF 2.3.2.3 S Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MEANEGAF_01702 1e-107 thiJ 2.7.11.1, 3.5.1.124 S DJ-1/PfpI family
MEANEGAF_01703 2.4e-189 I Alpha beta
MEANEGAF_01704 1.3e-117 ung2 3.2.2.27 L Uracil-DNA glycosylase
MEANEGAF_01705 1e-251 yjjP S Putative threonine/serine exporter
MEANEGAF_01706 1.5e-161 mleR K LysR family transcriptional regulator
MEANEGAF_01707 3.6e-227 thiI 2.8.1.4 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MEANEGAF_01708 2.9e-215 iscS2 2.8.1.7 E Aminotransferase class V
MEANEGAF_01709 2.2e-307 ezrA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
MEANEGAF_01710 1.7e-108 rpsD J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MEANEGAF_01712 6.2e-08 S YjcQ protein
MEANEGAF_01713 1.5e-17
MEANEGAF_01714 4.5e-63 J tRNA cytidylyltransferase activity
MEANEGAF_01715 1.2e-11 L Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed
MEANEGAF_01716 1.7e-51 S Protein of unknown function (DUF975)
MEANEGAF_01717 8.8e-44 tnpR1 L Resolvase, N terminal domain
MEANEGAF_01718 4.1e-257 dtpT U amino acid peptide transporter
MEANEGAF_01719 2.8e-169 D nuclear chromosome segregation
MEANEGAF_01720 4.3e-144 L transposase, IS605 OrfB family
MEANEGAF_01721 8.1e-282 ysaB V FtsX-like permease family
MEANEGAF_01722 7.1e-117 macB2 V ABC transporter, ATP-binding protein
MEANEGAF_01723 3.7e-105 T Histidine kinase-like ATPases
MEANEGAF_01724 5.6e-97 K response regulator
MEANEGAF_01725 3.1e-60 L hmm pf00665
MEANEGAF_01726 1.7e-176 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
MEANEGAF_01727 7e-155 tesE Q hydratase
MEANEGAF_01728 9.2e-190 yhjE EGP MFS transporter, metabolite H symporter (MHS) family protein
MEANEGAF_01730 3.4e-110
MEANEGAF_01731 9.8e-103 S Domain of unknown function (DUF4767)
MEANEGAF_01732 4.7e-54 K Helix-turn-helix domain
MEANEGAF_01733 2.3e-27 1.3.1.9 S Nitronate monooxygenase
MEANEGAF_01734 6.8e-136 1.3.1.9 S Nitronate monooxygenase
MEANEGAF_01736 1.2e-76 rocF 3.5.3.1, 3.5.3.11 E Arginase family
MEANEGAF_01737 5.4e-50 ybjQ S Belongs to the UPF0145 family
MEANEGAF_01738 3.1e-217 lacS G Transporter
MEANEGAF_01739 2.3e-83 lacR K Transcriptional regulator
MEANEGAF_01740 5.9e-152 glcU U sugar transport
MEANEGAF_01741 7.4e-251 yclK 2.7.13.3 T Histidine kinase
MEANEGAF_01742 9.7e-132 K response regulator
MEANEGAF_01744 1.4e-49 sirR K Helix-turn-helix diphteria tox regulatory element
MEANEGAF_01745 2.5e-249 mntH P H( )-stimulated, divalent metal cation uptake system
MEANEGAF_01746 1e-56 T Belongs to the universal stress protein A family
MEANEGAF_01747 2.9e-157 L hmm pf00665
MEANEGAF_01748 9e-40 citF 2.8.3.10 H Citrate (pro-3S)-lyase alpha chain
MEANEGAF_01749 6.7e-66 citG 2.4.2.52, 2.7.7.61 H 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase
MEANEGAF_01750 1.8e-38 citG 2.4.2.52, 2.7.7.61 H 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase
MEANEGAF_01751 1.5e-42 ydjP I Alpha/beta hydrolase family
MEANEGAF_01752 9.7e-101 P Cadmium resistance transporter
MEANEGAF_01753 3.2e-116 S Protein of unknown function (DUF554)
MEANEGAF_01754 8.4e-104 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MEANEGAF_01755 1.9e-158 P Belongs to the nlpA lipoprotein family
MEANEGAF_01756 1.5e-97 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MEANEGAF_01757 4.7e-09 S ChrR Cupin-like domain
MEANEGAF_01758 3.6e-09 K LysR substrate binding domain
MEANEGAF_01759 2.3e-106 1.1.1.90 C Zn-dependent alcohol dehydrogenases, class III
MEANEGAF_01760 5e-75 1.1.1.90 C Zn-dependent alcohol dehydrogenases, class III
MEANEGAF_01761 0.0 gltB 1.4.1.13, 1.4.1.14, 1.4.7.1, 2.1.1.21 E GXGXG motif
MEANEGAF_01762 4.3e-216 gltD 1.4.1.13, 1.4.1.14 E Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
MEANEGAF_01763 1e-38 V CAAX protease self-immunity
MEANEGAF_01764 6.1e-68 psiE S Phosphate-starvation-inducible E
MEANEGAF_01765 1.5e-149 thiD 2.5.1.3, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Phosphomethylpyrimidine kinase
MEANEGAF_01766 2.4e-113 thiE 2.5.1.3 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
MEANEGAF_01767 1.6e-143 thiD 2.5.1.3, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Phosphomethylpyrimidine kinase
MEANEGAF_01768 2.1e-137 thiM 2.7.1.50 H Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
MEANEGAF_01769 0.0 M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MEANEGAF_01770 1.1e-40 S integral membrane protein
MEANEGAF_01771 6e-39 S integral membrane protein
MEANEGAF_01772 9.7e-172 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
MEANEGAF_01774 1.2e-54
MEANEGAF_01775 7.6e-177 prmA J Ribosomal protein L11 methyltransferase
MEANEGAF_01776 2e-135 rsmE 2.1.1.193 J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
MEANEGAF_01777 9.8e-58
MEANEGAF_01778 0.0 relA 2.7.6.5 KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MEANEGAF_01779 2.4e-77 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
MEANEGAF_01780 1.3e-84 slyA K Transcriptional regulator
MEANEGAF_01781 1.1e-217 metC1 2.5.1.48, 4.4.1.8 E cystathionine
MEANEGAF_01782 3.3e-211 metB 2.5.1.48, 4.4.1.8 E Cys/Met metabolism PLP-dependent enzyme
MEANEGAF_01784 2.4e-67 yxeM ET Bacterial periplasmic substrate-binding proteins
MEANEGAF_01785 3.1e-47 yxeL K acetyltransferase
MEANEGAF_01786 2.2e-70 yxeN U ABC transporter, permease protein
MEANEGAF_01787 9.7e-78 yxeO 3.6.3.21 E ATPases associated with a variety of cellular activities
MEANEGAF_01788 1.7e-146 3.5.1.47 E Peptidase dimerisation domain
MEANEGAF_01789 1.1e-171 pcaB 4.3.2.2 F Adenylosuccinate lyase C-terminus
MEANEGAF_01790 6.7e-91 yxeQ S MmgE/PrpD family
MEANEGAF_01792 4.2e-113 papP P ABC transporter, permease protein
MEANEGAF_01793 2e-115 P ABC transporter permease
MEANEGAF_01794 3.9e-136 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
MEANEGAF_01795 3.1e-153 cjaA ET ABC transporter substrate-binding protein
MEANEGAF_01796 2.7e-137 IQ KR domain
MEANEGAF_01798 1.6e-213 hom1 1.1.1.3 E Homoserine dehydrogenase
MEANEGAF_01799 1.8e-158 metAA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to
MEANEGAF_01800 3.6e-247 mmuP E amino acid
MEANEGAF_01801 3.9e-173 mmuM 1.5.1.20, 2.1.1.10 H homocysteine S-methyltransferase
MEANEGAF_01802 1.4e-169 yniA G Phosphotransferase enzyme family
MEANEGAF_01803 1.6e-174 lytH 3.5.1.28 M Ami_3
MEANEGAF_01804 9.8e-194 6.3.1.20 H Lipoate-protein ligase
MEANEGAF_01805 1e-248 hisS 6.1.1.21 J histidyl-tRNA synthetase
MEANEGAF_01806 0.0 aspS 6.1.1.12 J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
MEANEGAF_01807 8.6e-130 yfeJ 6.3.5.2 F glutamine amidotransferase
MEANEGAF_01808 5.7e-23 rpsU J Belongs to the bacterial ribosomal protein bS21 family
MEANEGAF_01809 4.6e-71 yqeY S YqeY-like protein
MEANEGAF_01810 8.5e-179 phoH T phosphate starvation-inducible protein PhoH
MEANEGAF_01811 1.1e-80 ybeY 2.6.99.2, 3.5.4.5 S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MEANEGAF_01812 3e-66 dgkA 2.7.1.107, 2.7.1.66 M Diacylglycerol kinase
MEANEGAF_01813 8.7e-170 era S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MEANEGAF_01814 2.9e-156 recO L Involved in DNA repair and RecF pathway recombination
MEANEGAF_01815 4.9e-187 glyQ 6.1.1.14 J glycyl-tRNA synthetase alpha subunit
MEANEGAF_01816 0.0 glyS 6.1.1.14 J Glycyl-tRNA synthetase beta subunit
MEANEGAF_01817 0.0 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
MEANEGAF_01818 3.8e-207 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
MEANEGAF_01819 2.4e-153 L COG2801 Transposase and inactivated derivatives
MEANEGAF_01820 3e-184 fruR3 K Transcriptional regulator, LacI family
MEANEGAF_01821 4.2e-161 glxR 1.1.1.31, 1.1.1.60 I Dehydrogenase
MEANEGAF_01822 1.7e-165 rbsK 2.7.1.15 H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MEANEGAF_01823 3.2e-253 dsdA 4.3.1.18 E Belongs to the serine threonine dehydratase family. DsdA subfamily
MEANEGAF_01824 7.9e-239 cycA E Amino acid permease
MEANEGAF_01825 5.8e-97 ywrO S Flavodoxin-like fold
MEANEGAF_01826 4.6e-45 S Protein conserved in bacteria
MEANEGAF_01827 3e-56 1.14.99.57 S Antibiotic biosynthesis monooxygenase
MEANEGAF_01828 2.1e-51 S Sugar efflux transporter for intercellular exchange
MEANEGAF_01829 3.4e-17 xre K Helix-turn-helix domain
MEANEGAF_01830 9.8e-77
MEANEGAF_01831 0.0 trxB2 1.8.1.9 C Thioredoxin domain
MEANEGAF_01832 2.5e-103 ahpC 1.11.1.15 O Peroxiredoxin
MEANEGAF_01833 1.4e-80 S Virulence-associated protein E
MEANEGAF_01834 4.2e-115 pyrE 2.4.2.10, 4.1.1.23 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MEANEGAF_01835 1.4e-130 pyrF 4.1.1.23 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
MEANEGAF_01836 1.9e-95 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MEANEGAF_01837 1.9e-101 L Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed
MEANEGAF_01838 3e-78
MEANEGAF_01839 2.5e-101
MEANEGAF_01840 2.5e-87
MEANEGAF_01841 1e-69 S Asp23 family, cell envelope-related function
MEANEGAF_01842 6e-12 S Transglycosylase associated protein
MEANEGAF_01843 3.8e-16
MEANEGAF_01844 1.2e-263 npr 1.11.1.1 C NADH oxidase
MEANEGAF_01845 2.3e-107 L Integrase
MEANEGAF_01846 3.3e-45 K transcriptional regulator
MEANEGAF_01847 3.8e-66 GM NmrA-like family
MEANEGAF_01848 2.2e-25 C Flavodoxin
MEANEGAF_01849 3.1e-74 paiA 2.3.1.57 K Acetyltransferase (GNAT) domain
MEANEGAF_01850 4.2e-74 O OsmC-like protein
MEANEGAF_01851 2.8e-76 K Transcriptional regulator
MEANEGAF_01852 1.7e-162 proX M ABC transporter, substrate-binding protein, QAT family
MEANEGAF_01853 6.7e-108 proWZ P ABC transporter permease
MEANEGAF_01854 4.2e-141 proV E ABC transporter, ATP-binding protein
MEANEGAF_01855 3.1e-102 proW P ABC transporter, permease protein
MEANEGAF_01856 4.8e-208 2.1.1.72 V site-specific DNA-methyltransferase (adenine-specific) activity
MEANEGAF_01857 1.4e-145 C Zinc-binding dehydrogenase
MEANEGAF_01858 6.9e-195 bdhA 1.1.1.303, 1.1.1.4 C Zinc-binding dehydrogenase
MEANEGAF_01859 3.7e-221 4.4.1.8 E Aminotransferase, class I
MEANEGAF_01860 2.1e-179 pva3 3.5.1.24 M Linear amide C-N hydrolase, choloylglycine hydrolase family protein
MEANEGAF_01861 1e-201 xerS L Belongs to the 'phage' integrase family
MEANEGAF_01862 8.4e-96 ywkB S Membrane transport protein
MEANEGAF_01863 1.1e-234 icd 1.1.1.42 C Isocitrate/isopropylmalate dehydrogenase
MEANEGAF_01864 4.8e-151 pdxK 2.7.1.35 H Phosphomethylpyrimidine kinase
MEANEGAF_01865 2.6e-80 hmpT S ECF-type riboflavin transporter, S component
MEANEGAF_01866 5.6e-166 1.1.1.346 C Aldo keto reductase
MEANEGAF_01867 1.1e-159 S DUF218 domain
MEANEGAF_01870 1.8e-95 K Acetyltransferase (GNAT) domain
MEANEGAF_01871 1.8e-161 I alpha/beta hydrolase fold
MEANEGAF_01872 1e-72 S Phage minor capsid protein 2
MEANEGAF_01873 8.9e-35 S Phage minor capsid protein 2
MEANEGAF_01876 5e-215 2.6.1.1 E Aminotransferase
MEANEGAF_01877 1.3e-185 1.4.1.1, 4.3.1.12 E Ornithine cyclodeaminase/mu-crystallin family
MEANEGAF_01878 3.6e-244 EGP Sugar (and other) transporter
MEANEGAF_01879 4.6e-97 apt 2.4.2.22, 2.4.2.7 F Phosphoribosyl transferase domain
MEANEGAF_01880 2.2e-93 S Fic/DOC family
MEANEGAF_01881 1.6e-50 yncA 2.3.1.79 S Maltose acetyltransferase
MEANEGAF_01882 5.6e-107 lacA 2.3.1.18, 2.3.1.79 S Maltose acetyltransferase
MEANEGAF_01883 4.5e-199 ilvE 2.6.1.42 E Branched-chain amino acid aminotransferase
MEANEGAF_01884 2.7e-261 arcD E Amino acid permease
MEANEGAF_01885 1.4e-117 5.1.1.13 M racemase activity, acting on amino acids and derivatives
MEANEGAF_01886 7.9e-158 odh 1.5.1.28 C NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain
MEANEGAF_01887 2.1e-35 clcA P chloride
MEANEGAF_01888 5.4e-51 clcA P chloride
MEANEGAF_01889 7.2e-17 lmrB EGP Major facilitator Superfamily
MEANEGAF_01891 2.9e-246 yhjX P Major Facilitator Superfamily
MEANEGAF_01892 4.7e-120 S Protein of unknown function (DUF554)
MEANEGAF_01893 2.8e-257 rarA L recombination factor protein RarA
MEANEGAF_01895 0.0 oppD EP Psort location Cytoplasmic, score
MEANEGAF_01896 8e-243 codA 3.5.4.1 F cytosine deaminase
MEANEGAF_01897 4.7e-244 U Belongs to the purine-cytosine permease (2.A.39) family
MEANEGAF_01898 2.2e-81 yebR 1.8.4.14 T GAF domain-containing protein
MEANEGAF_01899 5.7e-94 ywnH 2.3.1.183 M Acetyltransferase (GNAT) domain
MEANEGAF_01900 3.4e-76 msrB 1.8.4.11, 1.8.4.12 O peptide methionine sulfoxide reductase
MEANEGAF_01901 2.3e-71 yqkB S Belongs to the HesB IscA family
MEANEGAF_01902 2.1e-171 ppaC 3.6.1.1 C inorganic pyrophosphatase
MEANEGAF_01903 5.2e-95 S Protein of unknown function (DUF1440)
MEANEGAF_01904 0.0 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
MEANEGAF_01905 0.0 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
MEANEGAF_01906 8e-103 plsY 2.3.1.15, 3.5.1.104 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
MEANEGAF_01907 4e-172 lacX 5.1.3.3 G Aldose 1-epimerase
MEANEGAF_01908 2.5e-155 D DNA integration
MEANEGAF_01909 0.0 topA 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MEANEGAF_01910 1.7e-66 dprA LU DNA protecting protein DprA
MEANEGAF_01911 2.5e-39 S dextransucrase activity
MEANEGAF_01912 1.1e-289 L Transposase IS66 family
MEANEGAF_01913 2.2e-240 L transposase, IS605 OrfB family
MEANEGAF_01914 1.2e-238 L transposase, IS605 OrfB family
MEANEGAF_01915 2.2e-44 L Transposase IS200 like
MEANEGAF_01916 3.2e-225 L transposase, IS605 OrfB family
MEANEGAF_01917 9.2e-21 L Transposase
MEANEGAF_01918 5.8e-34 T PemK-like, MazF-like toxin of type II toxin-antitoxin system
MEANEGAF_01919 1.2e-31 T SpoVT / AbrB like domain
MEANEGAF_01920 2.6e-184 S interspecies interaction between organisms
MEANEGAF_01921 2.1e-74 L PFAM transposase, IS4 family protein
MEANEGAF_01922 6.8e-20 L PFAM transposase, IS4 family protein
MEANEGAF_01923 2e-46 dxs 2.2.1.7 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MEANEGAF_01924 1.5e-69 dxs 2.2.1.7 HI 1-deoxy-D-xylulose-5-phosphate synthase
MEANEGAF_01925 3.8e-203 EG GntP family permease
MEANEGAF_01926 6.1e-205 glxK 2.7.1.165 G Belongs to the glycerate kinase type-1 family
MEANEGAF_01927 6.4e-37 M LysM domain
MEANEGAF_01928 1.1e-40
MEANEGAF_01929 8.2e-31 S zinc-ribbon domain
MEANEGAF_01932 1.6e-88 tpx 1.11.1.15 O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
MEANEGAF_01933 0.0 valS 6.1.1.9 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
MEANEGAF_01934 1.9e-250 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
MEANEGAF_01935 2.5e-115 radC L DNA repair protein
MEANEGAF_01936 4.2e-181 mreB D cell shape determining protein MreB
MEANEGAF_01937 3.7e-146 mreC M Involved in formation and maintenance of cell shape
MEANEGAF_01938 4.3e-92 mreD M rod shape-determining protein MreD
MEANEGAF_01939 1.4e-108 glnP P ABC transporter permease
MEANEGAF_01940 2.5e-115 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
MEANEGAF_01941 9.1e-161 aatB ET ABC transporter substrate-binding protein
MEANEGAF_01942 1.5e-231 ymfF S Peptidase M16 inactive domain protein
MEANEGAF_01943 9.9e-252 ymfH S Peptidase M16
MEANEGAF_01944 1.8e-96 ymfM S Helix-turn-helix domain
MEANEGAF_01945 8.5e-102 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MEANEGAF_01946 1.9e-231 cinA 3.5.1.42 S Belongs to the CinA family
MEANEGAF_01947 1.1e-192 recA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MEANEGAF_01948 8.4e-205 rny S Endoribonuclease that initiates mRNA decay
MEANEGAF_01949 0.0 mutS L that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MEANEGAF_01950 0.0 mutL L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MEANEGAF_01951 1.1e-104 ruvA 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
MEANEGAF_01952 1.1e-189 ruvB 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
MEANEGAF_01953 7.5e-177 2.4.2.29 F queuine tRNA-ribosyltransferase activity
MEANEGAF_01954 5.5e-42 yajC U Preprotein translocase
MEANEGAF_01955 3.4e-180 nrnA 3.1.13.3, 3.1.3.7 S DHHA1 domain protein
MEANEGAF_01956 8.4e-233 cshB 3.6.4.13 JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
MEANEGAF_01957 0.0 alaS 6.1.1.7 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MEANEGAF_01958 1.2e-42 yrzL S Belongs to the UPF0297 family
MEANEGAF_01959 9.6e-74 yqgF J Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MEANEGAF_01960 5.4e-31 yrzB S Belongs to the UPF0473 family
MEANEGAF_01961 1.6e-163 rnhC 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MEANEGAF_01962 4.7e-91 cvpA S Colicin V production protein
MEANEGAF_01963 0.0 mutS2 L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
MEANEGAF_01964 1e-53 trxA O Belongs to the thioredoxin family
MEANEGAF_01965 2.2e-224 clcA_2 P Chloride transporter, ClC family
MEANEGAF_01966 7.2e-95 yslB S Protein of unknown function (DUF2507)
MEANEGAF_01967 7.8e-146 murI 3.6.1.66, 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
MEANEGAF_01968 3.6e-108 rdgB 3.6.1.66, 5.1.1.3 F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MEANEGAF_01969 4e-95 S Phosphoesterase
MEANEGAF_01970 1.7e-151 3.1.3.102, 3.1.3.104, 3.1.3.23 S haloacid dehalogenase-like hydrolase
MEANEGAF_01971 2e-155 ykuT M mechanosensitive ion channel
MEANEGAF_01972 9.2e-26 WQ51_05790 S protein containing a divergent version of the methyl-accepting chemotaxis-like domain
MEANEGAF_01973 4.9e-70
MEANEGAF_01974 4.1e-214 pepQ 3.4.13.9 E Creatinase/Prolidase N-terminal domain
MEANEGAF_01975 2.2e-185 ccpA K catabolite control protein A
MEANEGAF_01976 6.2e-85
MEANEGAF_01977 3.7e-134 yebC K Transcriptional regulatory protein
MEANEGAF_01978 8.3e-84 mltD CBM50 M PFAM NLP P60 protein
MEANEGAF_01979 2.7e-128 ykcB M Dolichyl-phosphate-mannose-protein mannosyltransferase
MEANEGAF_01989 6.4e-41 L Transposase, IS116 IS110 IS902 family
MEANEGAF_01990 9.2e-23 L Helix-turn-helix domain
MEANEGAF_01991 4.7e-20 tra L Transposase and inactivated derivatives, IS30 family
MEANEGAF_01992 2.6e-62 S Phage terminase, large subunit
MEANEGAF_01993 1.4e-30 L Transposase
MEANEGAF_01994 0.0 xfp 4.1.2.22, 4.1.2.9 G Phosphoketolase
MEANEGAF_01995 9.1e-147 ybjI 3.1.3.102, 3.1.3.104, 3.1.3.23 S haloacid dehalogenase-like hydrolase
MEANEGAF_01996 9.2e-130 gntR K UbiC transcription regulator-associated domain protein
MEANEGAF_01997 7.1e-89 ybaK J Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MEANEGAF_01998 2.3e-128
MEANEGAF_01999 1.9e-264 pipD E Dipeptidase
MEANEGAF_02000 9.2e-155 3.2.1.52 GH20 G Xylose isomerase domain protein TIM barrel
MEANEGAF_02001 2.4e-84 M1-874 K Domain of unknown function (DUF1836)
MEANEGAF_02002 3e-90 GM epimerase
MEANEGAF_02003 7.6e-250 yhdP S Transporter associated domain
MEANEGAF_02004 2.4e-83 nrdI F Belongs to the NrdI family
MEANEGAF_02005 2.5e-74 S 3-demethylubiquinone-9 3-methyltransferase
MEANEGAF_02006 4.8e-205 yeaN P Transporter, major facilitator family protein
MEANEGAF_02007 2.6e-288 zwf 1.1.1.363, 1.1.1.49 G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MEANEGAF_02008 8.6e-273 gnd 1.1.1.343, 1.1.1.44 H Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MEANEGAF_02009 5.1e-81 uspA T universal stress protein
MEANEGAF_02010 1.1e-77 K AsnC family
MEANEGAF_02011 4.8e-158 C C4-dicarboxylate transmembrane transporter activity
MEANEGAF_02012 2.7e-60 kguE 2.7.1.45 G Xylose isomerase domain protein TIM barrel
MEANEGAF_02013 9.3e-141 IQ Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MEANEGAF_02014 3.1e-101 MA20_03535 1.1.1.399, 1.1.1.95 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MEANEGAF_02015 4.7e-177 K helix_turn _helix lactose operon repressor
MEANEGAF_02016 0.0 pepF E oligoendopeptidase F
MEANEGAF_02017 3.2e-234 gltP U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
MEANEGAF_02018 5.2e-119 S Membrane
MEANEGAF_02019 7.7e-42 L Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
MEANEGAF_02020 2e-62 L Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
MEANEGAF_02021 2.1e-277 lacS G Transporter
MEANEGAF_02022 0.0 rafA 3.2.1.22 G alpha-galactosidase
MEANEGAF_02023 4.6e-180 galR K Transcriptional regulator
MEANEGAF_02024 7.1e-283 galT 2.7.7.12 G UDP-glucose--hexose-1-phosphate uridylyltransferase
MEANEGAF_02025 3e-223 galK 2.7.1.6 F Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MEANEGAF_02026 2.4e-178 celE 3.2.1.4 GH5,GH9 E GDSL-like Lipase/Acylhydrolase family
MEANEGAF_02027 3.9e-142 ptp3 3.1.3.48 T Tyrosine phosphatase family
MEANEGAF_02028 1.8e-95 yxkA S Phosphatidylethanolamine-binding protein
MEANEGAF_02029 6.9e-36
MEANEGAF_02030 4.3e-135 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
MEANEGAF_02031 6.3e-120 tcyB U Binding-protein-dependent transport system inner membrane component
MEANEGAF_02032 6.3e-140 tcyA ET Belongs to the bacterial solute-binding protein 3 family
MEANEGAF_02033 2e-52
MEANEGAF_02034 1.2e-169 MA20_03535 1.1.1.399, 1.1.1.95 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MEANEGAF_02035 7.1e-78 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
MEANEGAF_02036 7.6e-146 pnuC H nicotinamide mononucleotide transporter
MEANEGAF_02037 4.2e-89 ymdB S Macro domain protein
MEANEGAF_02038 0.0 pepO 3.4.24.71 O Peptidase family M13
MEANEGAF_02039 1.8e-229 pbuG S permease
MEANEGAF_02040 1e-44
MEANEGAF_02041 7.3e-209 S Putative metallopeptidase domain
MEANEGAF_02042 2e-200 3.1.3.1 S associated with various cellular activities
MEANEGAF_02043 6.5e-116 mpg 3.2.2.21 L Belongs to the DNA glycosylase MPG family
MEANEGAF_02044 2.6e-64 yeaO S Protein of unknown function, DUF488
MEANEGAF_02046 1.4e-124 yrkL S Flavodoxin-like fold
MEANEGAF_02047 2.8e-54
MEANEGAF_02048 2.2e-108 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX
MEANEGAF_02049 2.3e-96 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MEANEGAF_02050 1e-100
MEANEGAF_02051 9.5e-26
MEANEGAF_02052 8.5e-168 scrR K Transcriptional regulator, LacI family

eggNOG-mapper v2 (Database: eggNOG v5.0, Jul. 2018 release)