ORF_ID e_value Gene_name EC_number CAZy COGs Description
MDBCMHFM_00001 1.3e-257 dnaA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MDBCMHFM_00002 5.3e-201 dnaN 2.7.7.7 L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
MDBCMHFM_00003 1.1e-29 yyzM S Protein conserved in bacteria
MDBCMHFM_00004 1.9e-203 ychF J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
MDBCMHFM_00005 1.4e-104 pth 3.1.1.29 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
MDBCMHFM_00006 0.0 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MDBCMHFM_00007 1.7e-39 yabO J Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
MDBCMHFM_00008 2.7e-61 divIC D Septum formation initiator
MDBCMHFM_00010 1.3e-240 XK27_09285 3.5.2.6 V Beta-lactamase enzyme family
MDBCMHFM_00011 5e-240 tilS 2.4.2.8, 6.3.4.19 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
MDBCMHFM_00012 3.4e-97 hpt 2.4.2.8, 6.3.4.19 F Belongs to the purine pyrimidine phosphoribosyltransferase family
MDBCMHFM_00013 0.0 ftsH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MDBCMHFM_00014 1.7e-162 L Transposase
MDBCMHFM_00015 1.1e-92 L Transposase
MDBCMHFM_00016 2.7e-28 L transposition
MDBCMHFM_00017 5.5e-81 L Integrase core domain protein
MDBCMHFM_00027 5.3e-11
MDBCMHFM_00033 1.3e-140 mreC M Involved in formation and maintenance of cell shape
MDBCMHFM_00034 8.2e-88 mreD M Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
MDBCMHFM_00035 4e-94 usp 3.5.1.28 CBM50 S CHAP domain
MDBCMHFM_00036 1.2e-174 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MDBCMHFM_00037 2.9e-218 araT 2.6.1.1 E Aminotransferase
MDBCMHFM_00038 7e-144 recO L Involved in DNA repair and RecF pathway recombination
MDBCMHFM_00039 9.6e-178 plsX 2.3.1.15 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
MDBCMHFM_00040 9.3e-34 acpP1 IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
MDBCMHFM_00041 9.9e-129 purC 4.1.1.21, 4.3.2.2, 6.3.2.6 F Belongs to the SAICAR synthetase family
MDBCMHFM_00042 0.0 purL 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MDBCMHFM_00043 1.3e-276 purF 2.4.2.14 F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MDBCMHFM_00044 4.8e-185 purM 6.3.3.1, 6.3.4.13 F Phosphoribosylformylglycinamidine cyclo-ligase
MDBCMHFM_00045 1.4e-101 purN 2.1.2.2 F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MDBCMHFM_00046 6.6e-295 purH 2.1.2.3, 3.5.4.10 F Bifunctional purine biosynthesis protein PurH
MDBCMHFM_00047 1e-90 L transposase activity
MDBCMHFM_00048 3.5e-50 L transposition
MDBCMHFM_00049 2e-32 L Integrase core domain protein
MDBCMHFM_00050 2.3e-161 S CHAP domain
MDBCMHFM_00051 3.4e-241 purD 6.3.4.13 F Belongs to the GARS family
MDBCMHFM_00052 4.9e-76 purE 5.4.99.18 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MDBCMHFM_00053 2.2e-204 purK 6.3.4.18 F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MDBCMHFM_00054 9.2e-141 1.1.1.169 H Ketopantoate reductase
MDBCMHFM_00055 8.7e-248 purB 4.3.2.2 F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MDBCMHFM_00056 0.0 argS 6.1.1.19 J Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
MDBCMHFM_00057 8.2e-70 argR K Regulates arginine biosynthesis genes
MDBCMHFM_00058 1e-57 ymcA 3.6.3.21 S Belongs to the UPF0342 family
MDBCMHFM_00059 0.0 mutS L that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MDBCMHFM_00060 7e-34 S Protein of unknown function (DUF3021)
MDBCMHFM_00061 1.2e-61 KT phosphorelay signal transduction system
MDBCMHFM_00063 0.0 mutL L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MDBCMHFM_00065 7.8e-103 ruvA 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
MDBCMHFM_00066 6.4e-107 tag 3.2.2.20 L 3-methyladenine DNA glycosylase
MDBCMHFM_00067 1e-232 cinA 3.5.1.42 S Belongs to the CinA family
MDBCMHFM_00068 4.7e-205 recA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MDBCMHFM_00069 2.3e-66 spxA_2 1.20.4.1 P Belongs to the ArsC family
MDBCMHFM_00076 2.6e-10
MDBCMHFM_00079 1.9e-07
MDBCMHFM_00084 0.0 polC 2.7.7.7 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MDBCMHFM_00085 1.2e-235 pepS E COG2309 Leucyl aminopeptidase (aminopeptidase T)
MDBCMHFM_00086 5.5e-36 XK27_02060 S Transglycosylase associated protein
MDBCMHFM_00087 2.6e-55 badR K DNA-binding transcription factor activity
MDBCMHFM_00088 2.1e-82 S reductase
MDBCMHFM_00089 6.9e-89 L Integrase core domain protein
MDBCMHFM_00090 6.4e-41 L transposition
MDBCMHFM_00092 7.9e-76 yocD 3.4.17.13 V carboxypeptidase activity
MDBCMHFM_00093 3.5e-79 yocD 3.4.17.13 V proteins, homologs of microcin C7 resistance protein MccF
MDBCMHFM_00096 1.3e-137 rpsB J Belongs to the universal ribosomal protein uS2 family
MDBCMHFM_00097 1.7e-182 tsf J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MDBCMHFM_00098 1.1e-83 S Putative small multi-drug export protein
MDBCMHFM_00099 6.2e-76 ctsR K Belongs to the CtsR family
MDBCMHFM_00100 0.0 clpC O Belongs to the ClpA ClpB family
MDBCMHFM_00101 3.2e-151 dacA 3.4.16.4 M Belongs to the peptidase S11 family
MDBCMHFM_00102 1.8e-32 dacA 3.4.16.4 M Belongs to the peptidase S11 family
MDBCMHFM_00103 1.2e-230 dacA 3.4.16.4 M Belongs to the peptidase S11 family
MDBCMHFM_00104 0.0 pnp 2.7.7.8 J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
MDBCMHFM_00105 2e-143 S SseB protein N-terminal domain
MDBCMHFM_00106 1.1e-112 cysE 2.3.1.30 E serine acetyltransferase
MDBCMHFM_00107 3.9e-259 cysS 6.1.1.16, 6.3.1.13 J Belongs to the class-I aminoacyl-tRNA synthetase family
MDBCMHFM_00108 4.2e-68 mrnC J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MDBCMHFM_00111 5.7e-135 trmH 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MDBCMHFM_00112 3.5e-91 yacP S RNA-binding protein containing a PIN domain
MDBCMHFM_00113 3.4e-155 degV S DegV family
MDBCMHFM_00115 1.8e-31 K helix-turn-helix
MDBCMHFM_00116 1.6e-182 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MDBCMHFM_00117 2e-79 rplM J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MDBCMHFM_00118 9.5e-65 rpsI J Belongs to the universal ribosomal protein uS9 family
MDBCMHFM_00119 9.3e-239 L Transposase
MDBCMHFM_00120 1.5e-35 K sequence-specific DNA binding
MDBCMHFM_00122 0.0 S Lantibiotic dehydratase, C terminus
MDBCMHFM_00123 1.6e-230 spaC2 V Lanthionine synthetase C family protein
MDBCMHFM_00124 3.3e-183 EGP Major facilitator Superfamily
MDBCMHFM_00125 1.6e-91 3.6.4.12 K Divergent AAA domain protein
MDBCMHFM_00126 4.8e-51 int L Belongs to the 'phage' integrase family
MDBCMHFM_00127 6.6e-105 int L Belongs to the 'phage' integrase family
MDBCMHFM_00128 2.8e-39 S Helix-turn-helix domain
MDBCMHFM_00129 4.9e-173
MDBCMHFM_00131 3.4e-75 isp2 S pathogenesis
MDBCMHFM_00132 2.2e-90 tnp L Transposase
MDBCMHFM_00133 3.3e-225 capA M Bacterial capsule synthesis protein
MDBCMHFM_00134 3.6e-39 gcvR T UPF0237 protein
MDBCMHFM_00135 1.9e-242 XK27_08635 S UPF0210 protein
MDBCMHFM_00136 8.3e-38 ais G alpha-ribazole phosphatase activity
MDBCMHFM_00137 7.9e-143 vanY 3.4.17.14 M D-alanyl-D-alanine carboxypeptidase
MDBCMHFM_00138 7.2e-101 acmA 3.2.1.17 NU amidase activity
MDBCMHFM_00139 5.4e-195 hrcA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
MDBCMHFM_00140 1.9e-69 grpE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MDBCMHFM_00141 8.4e-281 dnaK O Heat shock 70 kDa protein
MDBCMHFM_00142 5.6e-182 dnaJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
MDBCMHFM_00143 3.2e-138 truA 5.4.99.12 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
MDBCMHFM_00144 1.4e-136 thiD 2.7.1.35, 2.7.1.49, 2.7.4.7 H phosphomethylpyrimidine kinase
MDBCMHFM_00145 3.3e-72 hmpT S cog cog4720
MDBCMHFM_00148 9.9e-19 S Domain of unknown function (DUF4649)
MDBCMHFM_00149 2.8e-52 amd 3.5.1.47 E Peptidase dimerisation domain
MDBCMHFM_00150 4.7e-232 cfa 2.1.1.317, 2.1.1.79 M cyclopropane-fatty-acyl-phospholipid synthase
MDBCMHFM_00151 6.5e-87
MDBCMHFM_00152 1.6e-77 sigH K DNA-templated transcription, initiation
MDBCMHFM_00153 3.5e-149 ykuT M mechanosensitive ion channel
MDBCMHFM_00154 6.4e-219 tig D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
MDBCMHFM_00155 4.8e-73 rpoE K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
MDBCMHFM_00156 7.6e-310 pyrG 6.3.4.2 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
MDBCMHFM_00157 1.3e-84 XK27_03960 S Protein of unknown function (DUF3013)
MDBCMHFM_00158 3.7e-81 mutT3 3.6.1.13, 3.6.1.55 L NUDIX domain
MDBCMHFM_00159 3.7e-179 prmA J Ribosomal protein L11 methyltransferase
MDBCMHFM_00160 4.4e-135 rsmE 2.1.1.193 J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
MDBCMHFM_00161 0.0 cpdB 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
MDBCMHFM_00162 2.4e-83 nrdI F Belongs to the NrdI family
MDBCMHFM_00163 0.0 relA 2.7.6.5 KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MDBCMHFM_00164 2.3e-75 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
MDBCMHFM_00165 1.4e-09 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
MDBCMHFM_00166 2e-27 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
MDBCMHFM_00167 5.6e-59 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
MDBCMHFM_00168 1.9e-45 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
MDBCMHFM_00169 1.7e-237 ilvA 4.3.1.19 E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MDBCMHFM_00170 3.3e-112 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
MDBCMHFM_00171 1.1e-113 fnr5 K Catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
MDBCMHFM_00172 6.5e-202 yhjX P Major Facilitator
MDBCMHFM_00173 9.2e-43 rpsO J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MDBCMHFM_00174 5e-94 V VanZ like family
MDBCMHFM_00177 1e-123 glnQ E abc transporter atp-binding protein
MDBCMHFM_00178 1.8e-276 glnP P ABC transporter
MDBCMHFM_00179 9.1e-153 uppP 3.6.1.27 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
MDBCMHFM_00180 2.3e-136 mecA NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
MDBCMHFM_00181 3.8e-186 tagO 2.7.8.33, 2.7.8.35 M transferase
MDBCMHFM_00182 9.5e-144 sufC O ABC-type transport system involved in Fe-S cluster assembly, ATPase component
MDBCMHFM_00183 6.3e-235 sufD O assembly protein SufD
MDBCMHFM_00184 2.7e-238 sufS 2.8.1.7, 4.4.1.16 E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MDBCMHFM_00185 1.1e-74 nifU C SUF system FeS assembly protein, NifU family
MDBCMHFM_00186 3.5e-274 sufB O assembly protein SufB
MDBCMHFM_00187 7e-10 oppA E ABC transporter substrate-binding protein
MDBCMHFM_00188 2e-138 oppA E ABC transporter substrate-binding protein
MDBCMHFM_00189 4.2e-27 oppB P ABC-type dipeptide oligopeptide nickel transport systems, permease components
MDBCMHFM_00190 6.6e-11 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
MDBCMHFM_00191 1.7e-33 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
MDBCMHFM_00192 1.4e-38 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
MDBCMHFM_00193 3e-27 oppD P Belongs to the ABC transporter superfamily
MDBCMHFM_00194 2.5e-32 oppD P Belongs to the ABC transporter superfamily
MDBCMHFM_00195 1.2e-62 oppD P Belongs to the ABC transporter superfamily
MDBCMHFM_00196 7e-43 oppD P Belongs to the ABC transporter superfamily
MDBCMHFM_00197 7.5e-62 oppF P Belongs to the ABC transporter superfamily
MDBCMHFM_00198 3.4e-62 oppF P Belongs to the ABC transporter superfamily
MDBCMHFM_00199 6.4e-23
MDBCMHFM_00200 4.3e-158 hslO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MDBCMHFM_00201 7.4e-183 dus J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MDBCMHFM_00202 1.9e-223 EGP Major facilitator Superfamily
MDBCMHFM_00203 3.1e-72 adcR K transcriptional
MDBCMHFM_00204 2.2e-136 adcC P ABC transporter, ATP-binding protein
MDBCMHFM_00205 1.6e-127 adcB P ABC transporter (Permease
MDBCMHFM_00206 1.4e-162 mleP2 S Transporter, auxin efflux carrier (AEC) family protein
MDBCMHFM_00207 5.6e-65 ptsG 2.7.1.199, 2.7.1.208 G pts system
MDBCMHFM_00208 2.1e-150 ptsG 2.7.1.199, 2.7.1.208, 2.7.1.211 G pts system
MDBCMHFM_00209 3.6e-106 ptsG 2.7.1.199, 2.7.1.208, 2.7.1.211 G phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1
MDBCMHFM_00210 6.8e-158 rgfB 3.1.3.90 L Endonuclease/Exonuclease/phosphatase family
MDBCMHFM_00211 2.8e-257 pgi 5.3.1.9 G Belongs to the GPI family
MDBCMHFM_00212 1.9e-127 yeeN K transcriptional regulatory protein
MDBCMHFM_00213 9.8e-50 yajC U protein transport
MDBCMHFM_00214 1.1e-141 uppS 2.5.1.31 H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MDBCMHFM_00215 2.2e-145 cdsA 2.7.7.41 S Belongs to the CDS family
MDBCMHFM_00216 7.2e-231 rseP 3.4.21.107, 3.4.21.116 M zinc metalloprotease
MDBCMHFM_00217 0.0 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
MDBCMHFM_00218 0.0 WQ51_06230 S ABC transporter substrate binding protein
MDBCMHFM_00219 5.2e-142 cmpC S abc transporter atp-binding protein
MDBCMHFM_00220 1.3e-42 groS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MDBCMHFM_00221 4.1e-287 groL O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
MDBCMHFM_00222 4.4e-37 L Transposase
MDBCMHFM_00223 6.4e-18 L transposase activity
MDBCMHFM_00224 1.5e-30 L transposition
MDBCMHFM_00227 4.7e-43
MDBCMHFM_00228 6.8e-56 S TM2 domain
MDBCMHFM_00229 1.2e-165 rluA 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
MDBCMHFM_00230 0.0 pbp2A 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
MDBCMHFM_00231 3.3e-21 rpmG J Belongs to the bacterial ribosomal protein bL33 family
MDBCMHFM_00232 5.7e-25 secE U Belongs to the SecE SEC61-gamma family
MDBCMHFM_00233 8.4e-96 nusG K Participates in transcription elongation, termination and antitermination
MDBCMHFM_00234 4.6e-85 3.1.3.27, 3.1.3.4, 3.1.3.81, 3.6.1.27 I phosphatidate phosphatase activity
MDBCMHFM_00235 6e-55 cof Q phosphatase activity
MDBCMHFM_00236 6.2e-35 cof Q phosphatase activity
MDBCMHFM_00237 1.6e-137 glcR K transcriptional regulator (DeoR family)
MDBCMHFM_00238 0.0 leuS 6.1.1.4 J Belongs to the class-I aminoacyl-tRNA synthetase family
MDBCMHFM_00239 3.8e-40 K transcriptional
MDBCMHFM_00240 2e-24 S COG1073 Hydrolases of the alpha beta superfamily
MDBCMHFM_00241 6.5e-67 S COG1073 Hydrolases of the alpha beta superfamily
MDBCMHFM_00242 1.1e-65 S COG1073 Hydrolases of the alpha beta superfamily
MDBCMHFM_00243 8.2e-279 pncB 6.3.4.21 H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MDBCMHFM_00244 2.1e-151 nadE 6.3.1.5 H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
MDBCMHFM_00245 3.2e-77 yhaI L Membrane
MDBCMHFM_00246 1.7e-259 pepC 3.4.22.40 E aminopeptidase
MDBCMHFM_00247 0.0 ponA 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
MDBCMHFM_00248 2.5e-109 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
MDBCMHFM_00249 3.1e-95 ypsA S Belongs to the UPF0398 family
MDBCMHFM_00250 2.5e-50 gpsB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
MDBCMHFM_00251 1.5e-222 rlmL 2.1.1.173, 2.1.1.264 L Belongs to the methyltransferase superfamily
MDBCMHFM_00252 2.5e-296 mapZ D Early cell division protein that marks the future cell division site and supports proper FtsZ ring positioning
MDBCMHFM_00253 0.0 snf 2.7.11.1 L Superfamily II DNA RNA helicases, SNF2 family'
MDBCMHFM_00254 2.5e-23
MDBCMHFM_00255 2.6e-255 mpl 6.3.2.4, 6.3.2.45, 6.3.2.8 M Belongs to the MurCDEF family
MDBCMHFM_00256 7.3e-80 XK27_09675 K -acetyltransferase
MDBCMHFM_00257 0.0 mltG ADL Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MDBCMHFM_00258 1.6e-77 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
MDBCMHFM_00259 2e-58 L Integrase core domain protein
MDBCMHFM_00260 2.9e-165 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
MDBCMHFM_00261 7e-46 acyP 3.6.1.7 C Belongs to the acylphosphatase family
MDBCMHFM_00262 6.4e-131 spoU 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MDBCMHFM_00263 4.6e-88 XK27_09705 6.1.1.14 S HD superfamily hydrolase
MDBCMHFM_00264 3.3e-97 ybhL S Belongs to the BI1 family
MDBCMHFM_00267 9.6e-244 lysA 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
MDBCMHFM_00268 3.7e-91 K transcriptional regulator
MDBCMHFM_00269 7.6e-36 yneF S UPF0154 protein
MDBCMHFM_00270 3.8e-148 murI 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
MDBCMHFM_00271 7.1e-186 rdgB 3.6.1.66, 5.1.1.3 F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MDBCMHFM_00272 3.5e-99 XK27_09740 S Phosphoesterase
MDBCMHFM_00273 7.8e-85 ykuL S CBS domain
MDBCMHFM_00274 4.5e-135 xerD L tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site
MDBCMHFM_00275 3.8e-120 scpA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MDBCMHFM_00276 3e-99 scpB D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MDBCMHFM_00277 6.1e-140 rluB 5.4.99.19, 5.4.99.21, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
MDBCMHFM_00278 1.8e-40 yidD S Could be involved in insertion of integral membrane proteins into the membrane
MDBCMHFM_00279 4.8e-255 trkH P Cation transport protein
MDBCMHFM_00280 1.4e-245 trkA P Potassium transporter peripheral membrane component
MDBCMHFM_00281 2.7e-96 trmL 2.1.1.207 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
MDBCMHFM_00282 1.3e-88 ribU U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
MDBCMHFM_00283 4.8e-114 bcrC 3.6.1.27 I Membrane-associated phospholipid phosphatase
MDBCMHFM_00284 5.6e-161 K sequence-specific DNA binding
MDBCMHFM_00285 1.2e-32 V protein secretion by the type I secretion system
MDBCMHFM_00286 7.4e-36 V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
MDBCMHFM_00287 4.3e-57 V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
MDBCMHFM_00288 1.1e-34 V protein secretion by the type I secretion system
MDBCMHFM_00289 1.8e-27 comA V protein secretion by the type I secretion system
MDBCMHFM_00290 3.4e-68 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
MDBCMHFM_00291 2.6e-47 yhaI L Membrane
MDBCMHFM_00292 1e-55 S Domain of unknown function (DUF4173)
MDBCMHFM_00293 1.2e-94 ureI S AmiS/UreI family transporter
MDBCMHFM_00294 7.6e-46 ureA 3.5.1.5 E Belongs to the urease gamma subunit family
MDBCMHFM_00295 7.8e-54 ureB 3.5.1.5 E Belongs to the urease beta subunit family
MDBCMHFM_00296 0.0 ureC 3.5.1.5 E Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family
MDBCMHFM_00297 6.6e-78 ureE O enzyme active site formation
MDBCMHFM_00298 5.3e-130 ureF O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
MDBCMHFM_00299 9.5e-112 ureG KO Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MDBCMHFM_00300 4.9e-159 ureD O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
MDBCMHFM_00301 2.7e-177 cbiM P PDGLE domain
MDBCMHFM_00302 1.7e-137 P cobalt transport protein
MDBCMHFM_00303 1.6e-131 cbiO P ABC transporter
MDBCMHFM_00304 1.2e-152 ET amino acid transport
MDBCMHFM_00305 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MDBCMHFM_00306 0.0 3.3.1.1, 3.6.1.55, 3.6.1.67 F NUDIX domain
MDBCMHFM_00307 3.8e-205 EGP Transmembrane secretion effector
MDBCMHFM_00308 2.9e-151 ET amino acid transport
MDBCMHFM_00309 3.7e-165 metQ M Belongs to the NlpA lipoprotein family
MDBCMHFM_00310 7.1e-86 dapE 3.5.1.18 E COG0624, acetylornithine deacetylase succinyl-diaminopimelate desuccinylase and related deacylases
MDBCMHFM_00311 1.4e-62 dapE 3.5.1.18 E succinyl-diaminopimelate desuccinylase activity
MDBCMHFM_00312 1e-63 dapE 3.5.1.18 E succinyl-diaminopimelate desuccinylase activity
MDBCMHFM_00313 2.6e-189 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MDBCMHFM_00314 5.2e-98 metI P ABC transporter (Permease
MDBCMHFM_00315 4.6e-211 sstT E Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
MDBCMHFM_00316 5.5e-158 salL 2.5.1.63, 2.5.1.94 S S-adenosyl-l-methionine hydroxide adenosyltransferase
MDBCMHFM_00317 8e-94 S UPF0397 protein
MDBCMHFM_00318 0.0 ykoD P abc transporter atp-binding protein
MDBCMHFM_00319 1.2e-149 cbiQ P cobalt transport
MDBCMHFM_00320 0.0 tkt 2.2.1.1 G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MDBCMHFM_00321 1.4e-11 ulaG S L-ascorbate 6-phosphate lactonase
MDBCMHFM_00322 1.4e-121 ktrA P COG0569 K transport systems, NAD-binding component
MDBCMHFM_00323 5.2e-243 P COG0168 Trk-type K transport systems, membrane components
MDBCMHFM_00324 1.1e-130 rsmG 2.1.1.170 J Ribosomal RNA small subunit methyltransferase G
MDBCMHFM_00325 2.4e-90 yceD K metal-binding, possibly nucleic acid-binding protein
MDBCMHFM_00326 1.8e-122 T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MDBCMHFM_00327 2.8e-282 T PhoQ Sensor
MDBCMHFM_00328 4.7e-82 nrdR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MDBCMHFM_00329 6.5e-218 dnaB L Replication initiation and membrane attachment
MDBCMHFM_00330 4.4e-166 dnaI L Primosomal protein DnaI
MDBCMHFM_00331 2.6e-247 der 1.1.1.399, 1.1.1.95 S GTPase that plays an essential role in the late steps of ribosome biogenesis
MDBCMHFM_00333 1.2e-34
MDBCMHFM_00334 6.7e-14 yrdC 3.5.1.19 Q isochorismatase
MDBCMHFM_00335 3e-27 L Integrase core domain protein
MDBCMHFM_00336 3.4e-50 L transposition
MDBCMHFM_00337 2.5e-23 L Transposase
MDBCMHFM_00338 7.8e-28 L transposase activity
MDBCMHFM_00339 8.6e-232 serS 6.1.1.11 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MDBCMHFM_00340 4.2e-62 manO S protein conserved in bacteria
MDBCMHFM_00341 6.2e-168 manN G PTS system mannose fructose sorbose family IID component
MDBCMHFM_00342 1.7e-116 manM G pts system
MDBCMHFM_00343 2.8e-174 manL 2.7.1.191 G pts system
MDBCMHFM_00344 1.5e-140 XK27_00940 1.2.1.70, 3.5.1.9 S Metal-dependent hydrolase
MDBCMHFM_00345 1e-153 yitU 3.1.3.104 S hydrolases of the HAD superfamily
MDBCMHFM_00346 2.1e-247 pbuO S permease
MDBCMHFM_00347 1.4e-77 ydiB 2.7.1.221, 5.1.1.1 M ATPase or kinase
MDBCMHFM_00348 2.4e-92 XK27_05885 2.3.1.82 M Acetyltransferase GNAT Family
MDBCMHFM_00349 2.5e-220 brpA K Transcriptional
MDBCMHFM_00350 3.9e-81 rimP S Required for maturation of 30S ribosomal subunits
MDBCMHFM_00351 3.1e-212 nusA K Participates in both transcription termination and antitermination
MDBCMHFM_00352 1e-47 ylxR K Nucleic-acid-binding protein implicated in transcription termination
MDBCMHFM_00353 1.4e-41 ylxQ J ribosomal protein
MDBCMHFM_00354 0.0 infB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MDBCMHFM_00355 1.7e-57 rbfA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MDBCMHFM_00356 2e-22 yvdD 3.2.2.10 S Belongs to the LOG family
MDBCMHFM_00357 3.4e-37 yvdD 3.2.2.10 L Belongs to the LOG family
MDBCMHFM_00358 2.1e-213 femA 2.3.2.10, 2.3.2.16, 2.3.2.17, 2.3.2.18 V protein involved in methicillin resistance
MDBCMHFM_00359 1.4e-275 murE 6.3.2.13, 6.3.2.7 M to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MDBCMHFM_00360 4.5e-283 ytgP S Membrane protein involved in the export of O-antigen and teichoic acid
MDBCMHFM_00361 3.6e-95 pacL 3.6.3.8, 3.6.3.9 P cation transport ATPase
MDBCMHFM_00362 4.7e-202 metB 2.5.1.48, 4.4.1.8 E cystathionine
MDBCMHFM_00363 1e-223 malY 4.4.1.8 E COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
MDBCMHFM_00365 1.4e-09 sacB 2.4.1.10, 2.4.1.9, 3.2.1.26 GH32,GH68 G Belongs to the glycosyl hydrolase 68 family
MDBCMHFM_00366 4.4e-112 upp 2.4.2.9 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MDBCMHFM_00367 2.9e-105 clpP 3.4.21.92 OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
MDBCMHFM_00368 3.4e-74 ylbF S Belongs to the UPF0342 family
MDBCMHFM_00369 7.1e-46 ylbG S UPF0298 protein
MDBCMHFM_00370 1.1e-212 livJ E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component
MDBCMHFM_00371 1.9e-145 livH E Belongs to the binding-protein-dependent transport system permease family
MDBCMHFM_00372 1.4e-138 livM E Belongs to the binding-protein-dependent transport system permease family
MDBCMHFM_00373 9.6e-138 livG E COG0411 ABC-type branched-chain amino acid transport systems, ATPase component
MDBCMHFM_00374 9.6e-124 livF E COG0410 ABC-type branched-chain amino acid transport systems, ATPase component
MDBCMHFM_00375 2.8e-70 acuB S IMP dehydrogenase activity
MDBCMHFM_00376 3.3e-43 acuB S IMP dehydrogenase activity
MDBCMHFM_00377 2.2e-168 cysK 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
MDBCMHFM_00378 6.3e-111 yvyE 3.4.13.9 S YigZ family
MDBCMHFM_00379 1.7e-254 comFA L Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
MDBCMHFM_00380 4.4e-123 comFC S Competence protein
MDBCMHFM_00381 2.1e-94 hpf J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MDBCMHFM_00389 2.1e-166 ppaC 3.6.1.1 C inorganic pyrophosphatase
MDBCMHFM_00390 6.4e-108 S Domain of unknown function (DUF1803)
MDBCMHFM_00391 1.3e-101 ygaC J Belongs to the UPF0374 family
MDBCMHFM_00392 7.3e-133 recX 2.4.1.337 GT4 S Regulatory protein RecX
MDBCMHFM_00393 1.4e-259 rumA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MDBCMHFM_00394 8e-193 asnA 6.3.1.1 E aspartate--ammonia ligase
MDBCMHFM_00395 2.4e-256 lysC 2.7.2.4 E Belongs to the aspartokinase family
MDBCMHFM_00396 1.9e-115 S Haloacid dehalogenase-like hydrolase
MDBCMHFM_00397 2.4e-139 phaB 5.3.3.14, 5.3.3.18 I Belongs to the enoyl-CoA hydratase isomerase family
MDBCMHFM_00398 4e-72 marR K Transcriptional regulator, MarR family
MDBCMHFM_00399 2.3e-173 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MDBCMHFM_00400 3.3e-30 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
MDBCMHFM_00401 5.8e-172 fabK 1.3.1.9 S 2-Nitropropane dioxygenase
MDBCMHFM_00402 8.5e-165 fabD 2.3.1.39 I Malonyl CoA-acyl carrier protein transacylase
MDBCMHFM_00403 1.6e-126 IQ reductase
MDBCMHFM_00404 2.6e-233 fabF 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
MDBCMHFM_00405 7.7e-56 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
MDBCMHFM_00406 1.5e-71 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
MDBCMHFM_00407 4.8e-257 accC 6.3.4.14, 6.4.1.2 I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
MDBCMHFM_00408 4.6e-160 accD 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MDBCMHFM_00409 6.7e-139 accA 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
MDBCMHFM_00410 4.7e-90 luxS 4.4.1.21 H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
MDBCMHFM_00411 5.2e-65 tnp L Transposase
MDBCMHFM_00412 8.1e-203 rny D Endoribonuclease that initiates mRNA decay
MDBCMHFM_00413 1.8e-84 L Transposase
MDBCMHFM_00414 5.6e-114 fruR K transcriptional
MDBCMHFM_00415 5.5e-164 pfkB 2.7.1.11, 2.7.1.56 H Belongs to the carbohydrate kinase PfkB family. LacC subfamily
MDBCMHFM_00416 3.9e-54 fruA 2.7.1.202 GT PTS system, Lactose/Cellobiose specific IIB subunit
MDBCMHFM_00417 2.2e-49 fruA 2.7.1.202 GT PTS system, Lactose/Cellobiose specific IIB subunit
MDBCMHFM_00418 2.7e-126 fruA 2.7.1.202 G phosphotransferase system
MDBCMHFM_00419 5.3e-35 fruA 2.7.1.202 G phosphotransferase system
MDBCMHFM_00420 7.9e-260 gor 1.8.1.7 C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MDBCMHFM_00421 3.7e-243 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
MDBCMHFM_00423 6.1e-213 iscS2 2.8.1.7 E Cysteine sulfinate desulfinase cysteine desulfurase and related enzymes
MDBCMHFM_00424 6.5e-229 thiI 2.8.1.4 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MDBCMHFM_00425 1.1e-294 gtf1 2.4.1.52 GT4 M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
MDBCMHFM_00426 7.2e-258 gtf2 M A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1
MDBCMHFM_00427 6.4e-29 2.3.1.128 K acetyltransferase
MDBCMHFM_00428 4.5e-49 rplU J This protein binds to 23S rRNA in the presence of protein L20
MDBCMHFM_00429 1.5e-46 rpmA J Belongs to the bacterial ribosomal protein bL27 family
MDBCMHFM_00430 7.7e-134 ydaF_2 J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MDBCMHFM_00431 2.6e-64 WQ51_03320 S cog cog4835
MDBCMHFM_00432 9.8e-91 XK27_08360 S EDD domain protein, DegV family
MDBCMHFM_00433 3e-139 dapB 1.17.1.8 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
MDBCMHFM_00434 9.6e-225 cca 2.7.7.19, 2.7.7.72 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
MDBCMHFM_00435 0.0 yfmR S abc transporter atp-binding protein
MDBCMHFM_00436 1.6e-24 U response to pH
MDBCMHFM_00437 5.9e-140 3.6.1.13, 3.6.1.55 F AdP-ribose pyrophosphatase
MDBCMHFM_00438 3.8e-212 nadD 2.7.1.22, 2.7.7.1, 2.7.7.18, 3.6.1.55 H adenylyltransferase
MDBCMHFM_00439 1.8e-256 gdhA 1.4.1.4 E Belongs to the Glu Leu Phe Val dehydrogenases family
MDBCMHFM_00440 1e-69 def_1 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins
MDBCMHFM_00441 1.9e-77 K DNA-binding transcription factor activity
MDBCMHFM_00442 0.0 lmrA1 V abc transporter atp-binding protein
MDBCMHFM_00443 0.0 lmrA2 V abc transporter atp-binding protein
MDBCMHFM_00444 2.2e-18 K Acetyltransferase (GNAT) family
MDBCMHFM_00445 3.2e-78 sptS 2.7.13.3 T Histidine kinase
MDBCMHFM_00446 4.9e-131 pyrH 2.7.4.22 F Catalyzes the reversible phosphorylation of UMP to UDP
MDBCMHFM_00447 3.8e-91 frr J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
MDBCMHFM_00448 2e-160 cvfB S Protein conserved in bacteria
MDBCMHFM_00449 1.6e-34 yozE S Belongs to the UPF0346 family
MDBCMHFM_00450 5.1e-119 usp 3.5.1.104, 3.5.1.28 CBM50 S pathogenesis
MDBCMHFM_00451 2.3e-61 rlpA M LysM domain protein
MDBCMHFM_00452 8e-191 phoH T phosphate starvation-inducible protein PhoH
MDBCMHFM_00456 0.0 metG 6.1.1.10, 6.1.1.20 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MDBCMHFM_00457 1.8e-164 K transcriptional regulator (lysR family)
MDBCMHFM_00458 3.2e-183 coiA 3.6.4.12 S Competence protein
MDBCMHFM_00459 0.0 pepF E oligoendopeptidase F
MDBCMHFM_00460 7.1e-127 yrrM 2.1.1.104 S O-Methyltransferase
MDBCMHFM_00461 8.6e-167 prsA 3.1.3.16, 5.2.1.8 O peptidyl-prolyl cis-trans isomerase activity
MDBCMHFM_00462 0.0 alaS 6.1.1.7 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MDBCMHFM_00463 7.9e-24 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
MDBCMHFM_00464 6.9e-179 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
MDBCMHFM_00465 1.8e-30 3.4.17.14, 3.5.1.28 NU amidase activity
MDBCMHFM_00466 7.1e-89 3.4.17.14, 3.5.1.28 NU amidase activity
MDBCMHFM_00467 1.2e-146 cnhA 3.5.1.3 S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
MDBCMHFM_00468 5.3e-228 mtnE 2.6.1.83 E mutations do not affect methionine salvage in vivo however
MDBCMHFM_00469 1.5e-191 argC 1.2.1.38 E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MDBCMHFM_00470 1.5e-222 argJ 2.3.1.1, 2.3.1.35, 2.7.2.8 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MDBCMHFM_00471 1.9e-130 argB 2.7.2.8 E Belongs to the acetylglutamate kinase family. ArgB subfamily
MDBCMHFM_00472 1.6e-210 argD 2.6.1.11, 2.6.1.17 E acetylornithine aminotransferase
MDBCMHFM_00473 4.1e-132 yxkH G deacetylase
MDBCMHFM_00474 6.8e-237 hom 1.1.1.3, 2.7.2.4 E homoserine dehydrogenase
MDBCMHFM_00475 1.1e-153 thrB 2.7.1.39 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
MDBCMHFM_00476 5.5e-153 rarD S Transporter
MDBCMHFM_00477 2.2e-15 T peptidase
MDBCMHFM_00478 1.5e-13 coiA 3.6.4.12 S Competence protein
MDBCMHFM_00479 5.6e-109 S COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MDBCMHFM_00480 1.9e-46 2.3.1.128, 5.2.1.8 J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MDBCMHFM_00481 0.0 valS 6.1.1.9 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
MDBCMHFM_00482 3.2e-16 atpE C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MDBCMHFM_00483 4.3e-124 atpB C it plays a direct role in the translocation of protons across the membrane
MDBCMHFM_00484 3.3e-78 atpF C ATP synthase F(0) sector subunit b
MDBCMHFM_00485 9.3e-87 atpH C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MDBCMHFM_00486 3.8e-279 atpA 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MDBCMHFM_00487 2.5e-158 atpG C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MDBCMHFM_00488 2.7e-263 atpD 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MDBCMHFM_00489 5.2e-67 atpC C Produces ATP from ADP in the presence of a proton gradient across the membrane
MDBCMHFM_00490 2.8e-230 ftsW D Belongs to the SEDS family
MDBCMHFM_00491 9.5e-225 tuf J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MDBCMHFM_00492 1.4e-136 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
MDBCMHFM_00493 1.7e-111 tmk 2.7.4.9 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MDBCMHFM_00494 4.2e-161 holB 2.7.7.7 L dna polymerase iii
MDBCMHFM_00495 1.2e-135 yaaT S stage 0 sporulation protein
MDBCMHFM_00496 9.5e-55 yabA L Involved in initiation control of chromosome replication
MDBCMHFM_00497 4.6e-160 rsmI 2.1.1.198 H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MDBCMHFM_00498 7.5e-233 amt P Ammonium Transporter
MDBCMHFM_00499 1.1e-53 glnB K Belongs to the P(II) protein family
MDBCMHFM_00500 4.9e-106 mur1 NU mannosyl-glycoprotein
MDBCMHFM_00501 5.8e-149 XK27_04800 S Sucrose-6F-phosphate phosphohydrolase
MDBCMHFM_00502 1.2e-92 nptA P COG1283 Na phosphate symporter
MDBCMHFM_00503 8e-221 nagA 3.5.1.25 G Belongs to the metallo-dependent hydrolases superfamily. NagA family
MDBCMHFM_00504 4.9e-51
MDBCMHFM_00505 2.2e-25
MDBCMHFM_00506 3.9e-60
MDBCMHFM_00507 6.1e-63 S membrane
MDBCMHFM_00508 4.8e-176 glyQ 6.1.1.14 J glycyl-tRNA synthetase alpha subunit
MDBCMHFM_00509 0.0 glyS 6.1.1.14 J Glycyl-tRNA synthetase beta subunit
MDBCMHFM_00510 4.5e-39 ynzC S UPF0291 protein
MDBCMHFM_00511 1.8e-254 cycA E permease
MDBCMHFM_00512 2.4e-09 uvrX 2.7.7.7 L impB/mucB/samB family
MDBCMHFM_00513 4.8e-24 2.7.1.208, 2.7.1.211 G protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MDBCMHFM_00514 5.8e-71 pts33BCA G pts system
MDBCMHFM_00515 3.5e-143 pts33BCA G pts system
MDBCMHFM_00516 3.2e-141 ppiA 5.2.1.8 O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MDBCMHFM_00517 1.2e-165 L integrase core domain
MDBCMHFM_00518 5.1e-122 L Transposase
MDBCMHFM_00523 1.8e-167 fhuR K transcriptional regulator (lysR family)
MDBCMHFM_00524 8.8e-78 lspA 3.4.23.36 MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MDBCMHFM_00525 5e-162 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
MDBCMHFM_00526 3.7e-88 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MDBCMHFM_00527 4.9e-227 pyrP F uracil Permease
MDBCMHFM_00528 1e-173 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
MDBCMHFM_00529 1.1e-211 carA 6.3.5.5 F carbamoyl-phosphate synthetase glutamine chain
MDBCMHFM_00530 0.0 carB 6.3.5.5 F carbamoyl-phosphate synthetase ammonia chain
MDBCMHFM_00531 9.3e-239 L Transposase
MDBCMHFM_00532 4.6e-132 2.1.1.223 S Putative SAM-dependent methyltransferase
MDBCMHFM_00533 7.6e-21 acrA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MDBCMHFM_00534 6.2e-38 acrA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MDBCMHFM_00535 1.5e-18 V permease protein
MDBCMHFM_00536 3.6e-32 V efflux transmembrane transporter activity
MDBCMHFM_00537 7e-27 ytrF V efflux transmembrane transporter activity
MDBCMHFM_00538 5.6e-78 rplJ J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MDBCMHFM_00539 3.9e-52 rplL J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
MDBCMHFM_00540 7.6e-189 L Transposase
MDBCMHFM_00541 1.6e-18 L Integrase core domain
MDBCMHFM_00542 1.3e-117 devA 3.6.3.25 V abc transporter atp-binding protein
MDBCMHFM_00543 1.5e-48 hrtB V ABC transporter (Permease
MDBCMHFM_00544 1.2e-165 L integrase core domain
MDBCMHFM_00545 5.1e-122 L Transposase
MDBCMHFM_00546 5.7e-105 hrtB V MacB-like periplasmic core domain
MDBCMHFM_00549 3.4e-91 S MucBP domain
MDBCMHFM_00550 1.9e-49 M YSIRK type signal peptide
MDBCMHFM_00551 0.0 M the current gene model (or a revised gene model) may contain a
MDBCMHFM_00553 0.0 mdlB V abc transporter atp-binding protein
MDBCMHFM_00554 0.0 lmrA V abc transporter atp-binding protein
MDBCMHFM_00555 4.6e-199 queA 2.4.99.17 J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MDBCMHFM_00556 3.4e-121 nagB 3.1.1.31, 3.5.99.6 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
MDBCMHFM_00557 1.3e-214 2.7.13.3 T signal transduction protein with a C-terminal ATPase domain
MDBCMHFM_00558 2.5e-132 rr02 KT response regulator
MDBCMHFM_00559 1.1e-217 2.7.7.73, 2.7.7.80 H Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
MDBCMHFM_00560 4.8e-168 V ABC transporter
MDBCMHFM_00561 5.4e-122 sagI S ABC-2 type transporter
MDBCMHFM_00562 1e-195 yceA S Belongs to the UPF0176 family
MDBCMHFM_00563 1.2e-26 XK27_00085 K Transcriptional
MDBCMHFM_00564 4.3e-22
MDBCMHFM_00565 1.7e-142 deoD_1 2.4.2.3 F Phosphorylase superfamily
MDBCMHFM_00566 2.5e-113 S VIT family
MDBCMHFM_00567 7.4e-132 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
MDBCMHFM_00568 4e-220 hipO 3.5.1.47 E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
MDBCMHFM_00569 3.4e-17 ald 1.4.1.1 E alanine dehydrogenase activity
MDBCMHFM_00570 1.7e-46 ald 1.4.1.1 C Belongs to the AlaDH PNT family
MDBCMHFM_00571 8e-249 merA 1.16.1.1 C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MDBCMHFM_00572 4.6e-105 GBS0088 J protein conserved in bacteria
MDBCMHFM_00573 2.5e-142 mvk 1.1.1.88, 2.3.3.10, 2.7.1.36 I mevalonate kinase
MDBCMHFM_00574 6e-174 mvaD 4.1.1.33 I diphosphomevalonate decarboxylase
MDBCMHFM_00575 4.6e-180 mvaK2 2.7.1.36, 2.7.1.43, 2.7.4.2 I GHMP kinases N terminal domain
MDBCMHFM_00576 8.9e-192 fni 1.1.1.88, 5.3.3.2 C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
MDBCMHFM_00577 5.1e-254 glmU 2.3.1.157, 2.7.7.23 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MDBCMHFM_00578 1e-96 nudF 3.6.1.13 L AdP-ribose pyrophosphatase
MDBCMHFM_00579 2.5e-21
MDBCMHFM_00580 5.9e-118 mtnN 3.2.2.9 E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MDBCMHFM_00582 3.5e-07 U protein secretion
MDBCMHFM_00583 2.1e-50 U protein secretion
MDBCMHFM_00584 1.1e-11 U protein secretion
MDBCMHFM_00585 1.4e-192 dgs 2.4.1.208 GT4 M Glycosyltransferase, group 1 family protein
MDBCMHFM_00586 1.8e-248 mgs 2.4.1.337 GT4 M Glycosyltransferase, group 1 family protein
MDBCMHFM_00587 4.9e-21 XK27_13030
MDBCMHFM_00588 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MDBCMHFM_00589 9.9e-169 S hydrolases or acyltransferases (alpha beta hydrolase superfamily)
MDBCMHFM_00590 9.8e-163 S Protein of unknown function (DUF3114)
MDBCMHFM_00591 1.2e-22 S Protein of unknown function (DUF3114)
MDBCMHFM_00592 1.5e-118 yqfA K protein, Hemolysin III
MDBCMHFM_00593 1e-25 K hmm pf08876
MDBCMHFM_00594 2.7e-233 mvaA 1.1.1.34, 1.1.1.88, 2.3.1.9 C Belongs to the HMG-CoA reductase family
MDBCMHFM_00595 1.7e-218 mvaS 2.3.3.10 I synthase
MDBCMHFM_00596 2.2e-167 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MDBCMHFM_00597 3.4e-91 folA 1.5.1.3, 1.5.1.47, 2.1.1.45, 3.5.4.12 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MDBCMHFM_00598 9.7e-22
MDBCMHFM_00599 5.7e-225 clpX O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MDBCMHFM_00600 3e-110 engB D Necessary for normal cell division and for the maintenance of normal septation
MDBCMHFM_00601 1.3e-249 mmuP E amino acid
MDBCMHFM_00602 1.2e-177 mmuM 1.5.1.20, 2.1.1.10 H Homocysteine
MDBCMHFM_00603 1.4e-29 S Domain of unknown function (DUF1912)
MDBCMHFM_00604 4.9e-15 L Helix-hairpin-helix DNA-binding motif class 1
MDBCMHFM_00605 7.1e-102 plsY 2.3.1.15, 3.5.1.104 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
MDBCMHFM_00606 0.0 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
MDBCMHFM_00607 0.0 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
MDBCMHFM_00608 2.4e-200 ilvE 2.6.1.42 E Aminotransferase
MDBCMHFM_00609 4.8e-16 S Protein of unknown function (DUF2969)
MDBCMHFM_00612 8.4e-205 rpsA 1.17.7.4 J ribosomal protein S1
MDBCMHFM_00615 1e-100 S Domain of Unknown Function with PDB structure (DUF3862)
MDBCMHFM_00616 6.1e-70 M Pfam SNARE associated Golgi protein
MDBCMHFM_00617 1.3e-232 murN 2.3.2.10, 2.3.2.16 V FemAB family
MDBCMHFM_00618 9.3e-59 S oxidoreductase
MDBCMHFM_00619 9.7e-66 S oxidoreductase
MDBCMHFM_00620 3.7e-48 XK27_09445 S Domain of unknown function (DUF1827)
MDBCMHFM_00621 1.8e-86 mutT 3.5.4.33, 3.6.1.13, 3.6.1.55 L Belongs to the Nudix hydrolase family
MDBCMHFM_00622 0.0 clpE O Belongs to the ClpA ClpB family
MDBCMHFM_00623 1.2e-180 argF 2.1.3.3 E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MDBCMHFM_00624 1.3e-34 ykuJ S protein conserved in bacteria
MDBCMHFM_00625 7.5e-118 WQ51_01820 P Binding-protein-dependent transport system inner membrane component
MDBCMHFM_00626 2.2e-131 glnQ 3.6.3.21 E abc transporter atp-binding protein
MDBCMHFM_00627 5.3e-78 feoA P FeoA domain protein
MDBCMHFM_00628 0.0 feoB P transporter of a GTP-driven Fe(2 ) uptake system
MDBCMHFM_00629 1.5e-07
MDBCMHFM_00630 2.4e-104 1.1.1.133, 5.1.3.13 M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
MDBCMHFM_00631 2.2e-45 K sequence-specific DNA binding
MDBCMHFM_00632 1.5e-35 yugF I carboxylic ester hydrolase activity
MDBCMHFM_00633 7.5e-23 I Alpha/beta hydrolase family
MDBCMHFM_00634 3.9e-156 folD 1.5.1.5, 3.5.4.9 F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MDBCMHFM_00635 1.6e-149 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MDBCMHFM_00636 0.0 pbp2b 3.4.16.4 M penicillin-binding protein
MDBCMHFM_00637 4.9e-105 recR L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MDBCMHFM_00638 5.5e-62 licT K transcriptional antiterminator
MDBCMHFM_00639 6.8e-53 licT K transcriptional antiterminator
MDBCMHFM_00640 5.9e-88 ybeY 2.6.99.2, 3.5.4.5 S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MDBCMHFM_00641 1.7e-64 dgkA 2.7.1.107, 2.7.1.66 M Diacylglycerol kinase
MDBCMHFM_00642 1.3e-165 era M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MDBCMHFM_00643 1.9e-155 fpg 3.2.2.23, 4.2.99.18 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
MDBCMHFM_00644 1.3e-105 coaE 2.7.1.24, 3.2.2.23, 4.2.99.18 GH23 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MDBCMHFM_00645 6e-133 mdtG EGP Major facilitator Superfamily
MDBCMHFM_00646 9.5e-74 mdtG EGP Major facilitator Superfamily
MDBCMHFM_00647 2.6e-33 secG U Preprotein translocase subunit SecG
MDBCMHFM_00648 0.0 rnr J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
MDBCMHFM_00649 1.1e-80 smpB O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
MDBCMHFM_00650 9.6e-277 ppiB 5.2.1.8 G PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MDBCMHFM_00651 1.7e-63 yugI 5.3.1.9 J RNA binding protein, contains ribosomal protein S1 domain
MDBCMHFM_00652 4.2e-211 pepQ 3.4.13.9 E Belongs to the peptidase M24B family
MDBCMHFM_00653 4.4e-183 ccpA K Catabolite control protein A
MDBCMHFM_00654 2.8e-28 yyaQ S YjbR
MDBCMHFM_00655 6.6e-101 yyaQ V Protein conserved in bacteria
MDBCMHFM_00656 1.3e-207 glxK 2.7.1.165 G Belongs to the glycerate kinase type-1 family
MDBCMHFM_00657 1e-78 yueI S Protein of unknown function (DUF1694)
MDBCMHFM_00658 9.6e-247 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
MDBCMHFM_00659 2e-25 WQ51_00785
MDBCMHFM_00660 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
MDBCMHFM_00661 2e-219 ywbD 2.1.1.191 J Methyltransferase
MDBCMHFM_00662 8.6e-122 aroD 1.1.1.25, 4.2.1.10 E Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
MDBCMHFM_00663 1.7e-162 aroE 1.1.1.25 E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MDBCMHFM_00664 3.5e-202 aroB 2.7.1.71, 4.2.3.4 E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MDBCMHFM_00665 4.5e-219 aroC 4.2.3.5 E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MDBCMHFM_00666 2.2e-207 tyrA 1.3.1.12, 1.3.1.43 E prephenate dehydrogenase
MDBCMHFM_00667 3.2e-53 yheA S Belongs to the UPF0342 family
MDBCMHFM_00668 3e-173 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
MDBCMHFM_00669 2.6e-236 aroA 1.3.1.12, 1.3.1.43, 2.5.1.19 E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
MDBCMHFM_00670 1.7e-87 aroK 1.1.1.25, 2.7.1.71, 4.2.1.10, 4.2.3.4 F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MDBCMHFM_00671 2.3e-153 pheA 4.2.1.51 E Prephenate dehydratase
MDBCMHFM_00672 1.4e-238 msrR K Transcriptional regulator
MDBCMHFM_00673 4.3e-156 ydiA P C4-dicarboxylate transporter malic acid transport protein
MDBCMHFM_00674 7e-203 I acyl-CoA dehydrogenase
MDBCMHFM_00675 4.5e-97 mip S hydroperoxide reductase activity
MDBCMHFM_00676 5.2e-251 rumA 2.1.1.190 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MDBCMHFM_00677 2.4e-50 J Acetyltransferase (GNAT) domain
MDBCMHFM_00678 5.7e-95
MDBCMHFM_00679 3.1e-195 L Transposase
MDBCMHFM_00680 2.6e-29 L Transposase
MDBCMHFM_00681 1.5e-37 L transposase activity
MDBCMHFM_00682 3.2e-66 L COG2801 Transposase and inactivated derivatives
MDBCMHFM_00683 1.2e-73 L COG2801 Transposase and inactivated derivatives
MDBCMHFM_00684 8.9e-11
MDBCMHFM_00685 7.8e-59 S Protein of unknown function (DUF1722)
MDBCMHFM_00686 3.3e-64 yqeB S Pyrimidine dimer DNA glycosylase
MDBCMHFM_00688 1.2e-32
MDBCMHFM_00689 1.7e-26 S CAAX protease self-immunity
MDBCMHFM_00690 5.5e-42 S CAAX protease self-immunity
MDBCMHFM_00691 5.6e-27 estA E GDSL-like Lipase/Acylhydrolase
MDBCMHFM_00692 2.1e-95
MDBCMHFM_00693 0.0 cas9 L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
MDBCMHFM_00694 1.1e-172 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MDBCMHFM_00695 3.1e-53 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MDBCMHFM_00696 1e-185 S CRISPR-associated protein Csn2 subfamily St
MDBCMHFM_00697 2.7e-146 ycgQ S TIGR03943 family
MDBCMHFM_00698 1.2e-155 XK27_03015 S permease
MDBCMHFM_00700 0.0 yhgF K Transcriptional accessory protein
MDBCMHFM_00701 9.9e-42 pspC KT PspC domain
MDBCMHFM_00702 1e-170 hprK F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MDBCMHFM_00703 4e-147 lgt 2.1.1.199 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MDBCMHFM_00705 5.5e-69 ytxH S General stress protein
MDBCMHFM_00707 2e-177 yegQ O Peptidase U32
MDBCMHFM_00708 3.4e-252 yegQ O Peptidase U32
MDBCMHFM_00709 8.1e-46 S CHY zinc finger
MDBCMHFM_00710 9.3e-239 L Transposase
MDBCMHFM_00711 1.9e-87 bioY S biotin synthase
MDBCMHFM_00713 1.1e-33 XK27_12190 S protein conserved in bacteria
MDBCMHFM_00714 1.6e-249 L Transposase
MDBCMHFM_00715 1.1e-234 mntH P H( )-stimulated, divalent metal cation uptake system
MDBCMHFM_00716 9e-10
MDBCMHFM_00717 1.3e-66 nudG 3.6.1.55, 3.6.1.65 L Belongs to the Nudix hydrolase family
MDBCMHFM_00718 0.0 L helicase
MDBCMHFM_00719 4.3e-222 L Transposase
MDBCMHFM_00720 9.9e-288 lysS 6.1.1.6 J Belongs to the class-II aminoacyl-tRNA synthetase family
MDBCMHFM_00721 1e-163 M LysM domain
MDBCMHFM_00722 7.6e-16
MDBCMHFM_00723 1.5e-174 S hydrolase
MDBCMHFM_00724 4.3e-115 pgm6 5.4.2.11, 5.4.2.12 G Phosphoglycerate mutase
MDBCMHFM_00725 7.9e-82 ybaK S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MDBCMHFM_00726 4.5e-145 XK27_00880 3.5.1.28 M Glycosyl hydrolase, family 25
MDBCMHFM_00727 2.7e-27 P Hemerythrin HHE cation binding domain protein
MDBCMHFM_00728 6.1e-114 1.14.14.5 C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MDBCMHFM_00729 1.7e-10 MA20_36090 S Protein of unknown function (DUF2974)
MDBCMHFM_00730 4.7e-23 MA20_36090 S Protein of unknown function (DUF2974)
MDBCMHFM_00732 2.5e-103 sdh 1.1.1.276, 1.1.1.313, 1.1.1.381 S Belongs to the short-chain dehydrogenases reductases (SDR) family
MDBCMHFM_00733 0.0 hsdR 3.1.21.3 L Subunit R is required for both nuclease and ATPase activities, but not for modification
MDBCMHFM_00734 1.4e-68
MDBCMHFM_00736 5.3e-08
MDBCMHFM_00737 2.8e-131 hsdS 3.1.21.3 V Type I restriction modification DNA specificity domain
MDBCMHFM_00738 0.0 S KAP family P-loop domain
MDBCMHFM_00739 3e-131 S Protein conserved in bacteria
MDBCMHFM_00740 9.6e-305 hsdM 2.1.1.72 V type I restriction-modification system
MDBCMHFM_00741 4.8e-61 spd F DNA RNA non-specific endonuclease
MDBCMHFM_00742 9.9e-90 spd F DNA RNA non-specific endonuclease
MDBCMHFM_00743 9e-93 lemA S LemA family
MDBCMHFM_00744 6.4e-133 htpX O Belongs to the peptidase M48B family
MDBCMHFM_00745 1.8e-73 S Psort location CytoplasmicMembrane, score
MDBCMHFM_00746 6.2e-56 S Domain of unknown function (DUF4430)
MDBCMHFM_00747 0.0 ppc 4.1.1.31 H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MDBCMHFM_00748 1.2e-183 holA 2.7.7.7 L DNA polymerase III delta subunit
MDBCMHFM_00749 8.5e-113 sodA 1.15.1.1 C radicals which are normally produced within the cells and which are toxic to biological systems
MDBCMHFM_00750 2e-186 3.5.2.6 V D-alanyl-D-alanine carboxypeptidase
MDBCMHFM_00751 4.4e-115 pilD 3.4.23.43 NOU Bacterial Peptidase A24 N-terminal domain
MDBCMHFM_00752 3.5e-91 dps P Belongs to the Dps family
MDBCMHFM_00753 1.1e-80 perR P Belongs to the Fur family
MDBCMHFM_00754 8.4e-28 yqgQ S protein conserved in bacteria
MDBCMHFM_00755 2.2e-179 glk 2.7.1.2 G Glucokinase
MDBCMHFM_00756 0.0 typA T GTP-binding protein TypA
MDBCMHFM_00758 4.6e-252 murD 6.3.2.9 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MDBCMHFM_00759 1e-201 murG 2.4.1.227 GT28 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MDBCMHFM_00760 9.7e-171 divIB D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
MDBCMHFM_00761 8e-252 ftsA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
MDBCMHFM_00762 5.4e-237 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MDBCMHFM_00763 2.3e-122 ylmE S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MDBCMHFM_00764 6.8e-96 sepF D cell septum assembly
MDBCMHFM_00765 2.6e-34 yggT D integral membrane protein
MDBCMHFM_00766 1.2e-143 ylmH T S4 RNA-binding domain
MDBCMHFM_00767 1.8e-135 divIVA D Cell division protein DivIVA
MDBCMHFM_00768 0.0 ileS 6.1.1.5 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MDBCMHFM_00769 5.5e-30
MDBCMHFM_00770 8.4e-10
MDBCMHFM_00771 3.6e-230 mntH P Mn2 and Fe2 transporters of the NRAMP family
MDBCMHFM_00772 2e-45 rpmE2 J 50S ribosomal protein L31
MDBCMHFM_00773 1.5e-177 apbE 2.7.1.180 H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
MDBCMHFM_00774 1e-184 nrnA 3.1.13.3, 3.1.3.7 S domain protein
MDBCMHFM_00775 3.1e-155 gst O Glutathione S-transferase
MDBCMHFM_00776 1.6e-188 add 3.5.4.4 F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MDBCMHFM_00777 2.4e-112 tdk 2.7.1.21 F thymidine kinase
MDBCMHFM_00778 3e-193 prfA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MDBCMHFM_00779 1.2e-154 prmB 2.1.1.297, 2.1.1.298 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
MDBCMHFM_00780 9.7e-109 ywlC 2.7.7.87, 3.1.3.48 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
MDBCMHFM_00781 1.8e-234 glyA 2.1.2.1 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MDBCMHFM_00782 1.2e-177 ndpA S 37-kD nucleoid-associated bacterial protein
MDBCMHFM_00783 6.6e-105 pvaA M lytic transglycosylase activity
MDBCMHFM_00784 0.0 yfiB1 V abc transporter atp-binding protein
MDBCMHFM_00785 0.0 XK27_10035 V abc transporter atp-binding protein
MDBCMHFM_00786 1.7e-09 S D-Ala-teichoic acid biosynthesis protein
MDBCMHFM_00787 1.4e-297 dltA 6.1.1.13 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MDBCMHFM_00788 3.9e-237 dltB M Membrane protein involved in D-alanine export
MDBCMHFM_00789 1.7e-35 dltC 6.1.1.13 IQ Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MDBCMHFM_00790 3.6e-230 dltD M Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MDBCMHFM_00791 2.1e-85 L Integrase core domain protein
MDBCMHFM_00792 6.5e-54 L transposition
MDBCMHFM_00793 4.5e-19 L transposase activity
MDBCMHFM_00794 0.0 3.6.3.8 P cation transport ATPase
MDBCMHFM_00795 0.0 pabB 2.6.1.85, 4.1.3.27, 4.1.3.38 EH component I
MDBCMHFM_00797 2.9e-12
MDBCMHFM_00799 1.4e-289 S DNA primase
MDBCMHFM_00800 1.2e-149 KL Phage plasmid primase P4 family
MDBCMHFM_00801 3.1e-22
MDBCMHFM_00805 1.8e-19 K Cro/C1-type HTH DNA-binding domain
MDBCMHFM_00806 1e-21 xre K transcriptional
MDBCMHFM_00807 6.9e-220 sip L Belongs to the 'phage' integrase family
MDBCMHFM_00809 0.0 metE 2.1.1.14 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MDBCMHFM_00810 7.3e-166 metF 1.5.1.20 E reductase
MDBCMHFM_00811 0.0 pgm 5.4.2.2, 5.4.2.8 G Phosphoglucomutase
MDBCMHFM_00812 1.7e-94 panT S ECF transporter, substrate-specific component
MDBCMHFM_00813 4.8e-94 coaBC 4.1.1.36, 6.3.2.5 H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MDBCMHFM_00814 1.2e-120 coaB 4.1.1.36, 6.3.2.5 H Phosphopantothenate-cysteine ligase
MDBCMHFM_00815 0.0 fhs 6.3.4.3 F Belongs to the formate--tetrahydrofolate ligase family
MDBCMHFM_00816 6.4e-66 T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MDBCMHFM_00817 2.8e-40 T PhoQ Sensor
MDBCMHFM_00818 2.2e-43 T PhoQ Sensor
MDBCMHFM_00819 3.6e-88 T PhoQ Sensor
MDBCMHFM_00820 5.1e-122 L Transposase
MDBCMHFM_00821 1.2e-165 L integrase core domain
MDBCMHFM_00822 2.1e-219 L Transposase
MDBCMHFM_00823 1.7e-28 potC P Binding-protein-dependent transport system inner membrane component
MDBCMHFM_00824 8.9e-206 potD P spermidine putrescine ABC transporter
MDBCMHFM_00825 3.1e-268 clcA P Chloride transporter, ClC family
MDBCMHFM_00826 0.0 prtS 3.4.21.96 O Belongs to the peptidase S8 family
MDBCMHFM_00827 1.9e-21 L Helix-turn-helix domain
MDBCMHFM_00828 1.1e-82 L Helix-turn-helix domain
MDBCMHFM_00829 9.8e-163 L Integrase core domain protein
MDBCMHFM_00830 1.6e-249 L Transposase
MDBCMHFM_00831 2.1e-30 rpsT J rRNA binding
MDBCMHFM_00832 1.9e-172 coaA 2.7.1.33 F Pantothenic acid kinase
MDBCMHFM_00833 1.8e-107 rsmC 2.1.1.172 J Methyltransferase small domain protein
MDBCMHFM_00834 1.2e-57 pdp 2.4.2.2, 2.4.2.4 F Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate
MDBCMHFM_00835 1.3e-97 pdp 2.4.2.2, 2.4.2.4 F Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate
MDBCMHFM_00836 1.4e-22 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MDBCMHFM_00837 4e-63 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MDBCMHFM_00838 1.3e-69 cdd 2.4.2.2, 3.5.4.5 F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
MDBCMHFM_00839 9.5e-192 tcsA S ABC-type transport system, periplasmic component surface lipoprotein
MDBCMHFM_00840 8.3e-282 xylG 3.6.3.17 S ABC transporter, ATP-binding protein
MDBCMHFM_00841 4.7e-191 yufP S Belongs to the binding-protein-dependent transport system permease family
MDBCMHFM_00842 4.8e-171 yufQ S Belongs to the binding-protein-dependent transport system permease family
MDBCMHFM_00843 8.9e-121 ycbL 3.1.2.6 S COG0491 Zn-dependent hydrolases, including glyoxylases
MDBCMHFM_00844 0.0 dinG 2.7.7.7, 3.6.4.12 L helicase involved in DNA repair and perhaps also replication
MDBCMHFM_00845 3.1e-81 ypmB S Protein conserved in bacteria
MDBCMHFM_00846 6.5e-218 aspB 2.6.1.1, 2.6.1.14 E Aminotransferase
MDBCMHFM_00847 1.7e-262 asnS 6.1.1.22 J Catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
MDBCMHFM_00849 8.9e-30
MDBCMHFM_00850 3e-13
MDBCMHFM_00851 3e-63 tdcF 3.5.99.10 J endoribonuclease L-PSP
MDBCMHFM_00852 4.4e-123 queC 6.3.4.20 F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MDBCMHFM_00853 2.2e-81 queD 4.1.2.50, 4.2.3.12 H synthase
MDBCMHFM_00854 3.9e-133 queE 1.97.1.4, 4.3.99.3 H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
MDBCMHFM_00855 2.5e-94 queF 1.7.1.13 S Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily
MDBCMHFM_00856 4.2e-18 D nuclear chromosome segregation
MDBCMHFM_00857 2.8e-137 yejC S cyclic nucleotide-binding protein
MDBCMHFM_00858 1.2e-163 rapZ S Displays ATPase and GTPase activities
MDBCMHFM_00859 3.6e-182 ybhK S Required for morphogenesis under gluconeogenic growth conditions
MDBCMHFM_00860 8.7e-162 whiA K May be required for sporulation
MDBCMHFM_00861 6.4e-168 pepD E Dipeptidase
MDBCMHFM_00862 5.4e-32 cspD K Cold shock protein domain
MDBCMHFM_00863 8e-42 K Cold-Shock Protein
MDBCMHFM_00864 1.2e-165 L integrase core domain
MDBCMHFM_00865 5.1e-122 L Transposase
MDBCMHFM_00866 3.3e-222 L Transposase
MDBCMHFM_00867 0.0 copB 3.6.3.4 P P-type ATPase
MDBCMHFM_00868 3.3e-222 L Transposase
MDBCMHFM_00869 2.9e-190 3.1.21.3 L Subunit R is required for both nuclease and ATPase activities, but not for modification
MDBCMHFM_00870 2.3e-170 mccA 2.5.1.134, 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
MDBCMHFM_00871 2.7e-219 metC 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
MDBCMHFM_00872 1.5e-59 cysE 2.3.1.30 E serine acetyltransferase
MDBCMHFM_00873 3.3e-222 L Transposase
MDBCMHFM_00874 3.7e-54 hsdS 2.1.1.72, 3.1.21.3 V type I restriction modification DNA specificity domain
MDBCMHFM_00875 1.7e-111 hsdM 2.1.1.72 V type I restriction-modification system
MDBCMHFM_00876 3.7e-157 glcU U Glucose uptake
MDBCMHFM_00877 1.8e-08 4.2.1.53 S Myosin-crossreactive antigen
MDBCMHFM_00878 5.9e-79 hsdM 2.1.1.72 V HsdM N-terminal domain
MDBCMHFM_00879 2.2e-101 XK27_10720 D peptidase activity
MDBCMHFM_00880 3.1e-292 adcA P Belongs to the bacterial solute-binding protein 9 family
MDBCMHFM_00881 1.7e-08
MDBCMHFM_00883 1.2e-172 yeiH S Membrane
MDBCMHFM_00884 5.5e-119 mur1 NU muramidase
MDBCMHFM_00885 2.4e-83 L transposition
MDBCMHFM_00886 4.5e-166 cpsY K Transcriptional regulator
MDBCMHFM_00887 0.0 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
MDBCMHFM_00888 2.5e-58 phnA P Alkylphosphonate utilization operon protein PhnA
MDBCMHFM_00889 2e-104 artQ P ABC transporter (Permease
MDBCMHFM_00890 1.8e-113 glnQ 3.6.3.21 E abc transporter atp-binding protein
MDBCMHFM_00891 2.5e-158 aatB ET ABC transporter substrate-binding protein
MDBCMHFM_00892 1e-137 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MDBCMHFM_00893 2.1e-07
MDBCMHFM_00894 4.1e-26
MDBCMHFM_00895 8.1e-60 adhP 1.1.1.1 C alcohol dehydrogenase
MDBCMHFM_00896 1.7e-17 adhP 1.1.1.1 C alcohol dehydrogenase
MDBCMHFM_00897 7.2e-30 adhP 1.1.1.1 C alcohol dehydrogenase
MDBCMHFM_00898 4.6e-78 sthIM 2.1.1.72 L Adenine specific DNA methylase Mod
MDBCMHFM_00899 3.9e-303 guaA 2.3.1.128, 6.3.5.2 F Catalyzes the synthesis of GMP from XMP
MDBCMHFM_00900 2e-126 gntR1 K transcriptional
MDBCMHFM_00901 1.1e-53 ylxM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
MDBCMHFM_00902 2.2e-269 ffh 3.6.5.4 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MDBCMHFM_00903 4.1e-87 niaX
MDBCMHFM_00904 8.6e-90 niaR S small molecule binding protein (contains 3H domain)
MDBCMHFM_00905 1.8e-127 K DNA-binding helix-turn-helix protein
MDBCMHFM_00906 1.1e-158 ylqF S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MDBCMHFM_00907 6.9e-136 rnhB 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MDBCMHFM_00908 8.2e-168 GK ROK family
MDBCMHFM_00909 8.3e-159 dprA LU DNA protecting protein DprA
MDBCMHFM_00910 0.0 topA 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MDBCMHFM_00911 1.4e-150 S TraX protein
MDBCMHFM_00912 2.2e-122 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MDBCMHFM_00913 2.4e-251 T PhoQ Sensor
MDBCMHFM_00914 1.5e-258 trmFO 2.1.1.74 J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
MDBCMHFM_00915 1.1e-152 XK27_05470 E Methionine synthase
MDBCMHFM_00916 1.7e-75 ndk 2.7.4.6 F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
MDBCMHFM_00917 2.7e-48 pspE P Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MDBCMHFM_00918 2.4e-37 IQ Acetoin reductase
MDBCMHFM_00919 5.9e-45 IQ Acetoin reductase
MDBCMHFM_00921 0.0 lepA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
MDBCMHFM_00922 1.8e-156 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
MDBCMHFM_00924 4.3e-222 L Transposase
MDBCMHFM_00926 1.1e-212 pqqE C radical SAM domain protein
MDBCMHFM_00927 4.4e-135 speB 3.5.3.11 E hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
MDBCMHFM_00928 6.6e-61 EGP Major facilitator Superfamily
MDBCMHFM_00929 0.0 alsS 2.2.1.6 EH Belongs to the TPP enzyme family
MDBCMHFM_00930 8.8e-133 budA 4.1.1.5 H Belongs to the alpha-acetolactate decarboxylase family
MDBCMHFM_00931 7.3e-13
MDBCMHFM_00932 3.6e-160 L Transposase
MDBCMHFM_00933 6.4e-104 V ABC transporter (Permease
MDBCMHFM_00934 2.8e-115 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
MDBCMHFM_00935 1.6e-10
MDBCMHFM_00936 9e-98 K Transcriptional regulator, TetR family
MDBCMHFM_00937 1.8e-159 czcD P cation diffusion facilitator family transporter
MDBCMHFM_00938 2.7e-210 hemH 4.99.1.1, 4.99.1.9 H Catalyzes the ferrous insertion into protoporphyrin IX
MDBCMHFM_00939 6.2e-196 adhB 1.1.1.1, 1.1.1.14 E Dehydrogenase
MDBCMHFM_00940 6e-08 S Hydrolases of the alpha beta superfamily
MDBCMHFM_00941 7.9e-17 S Alpha/beta hydrolase of unknown function (DUF915)
MDBCMHFM_00942 4.5e-79 S Alpha/beta hydrolase of unknown function (DUF915)
MDBCMHFM_00945 1.2e-143 2.4.2.3 F Phosphorylase superfamily
MDBCMHFM_00946 4.1e-118 gph 3.1.3.18 S HAD hydrolase, family IA, variant 1
MDBCMHFM_00947 1.8e-24 yclQ P ABC-type enterochelin transport system, periplasmic component
MDBCMHFM_00948 3.6e-18 yclQ P ABC-type enterochelin transport system, periplasmic component
MDBCMHFM_00949 6.3e-12 dinF V Mate efflux family protein
MDBCMHFM_00951 9.2e-311 FbpA K RNA-binding protein homologous to eukaryotic snRNP
MDBCMHFM_00952 1.8e-88 S TraX protein
MDBCMHFM_00953 1.7e-96 thiJ 2.7.11.1, 3.5.1.124 S DJ-1 family
MDBCMHFM_00954 1.3e-148 pyrK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )
MDBCMHFM_00955 3.2e-175 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
MDBCMHFM_00956 2.8e-185 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MDBCMHFM_00957 9.8e-55 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MDBCMHFM_00958 6.8e-133 cas6 S CRISPR-associated endoribonuclease Cas6
MDBCMHFM_00959 0.0 csm1 S CRISPR-associated protein Csm1 family
MDBCMHFM_00960 2.5e-62 csm2 L Csm2 Type III-A
MDBCMHFM_00961 1.6e-117 csm3 L RAMP superfamily
MDBCMHFM_00962 2.3e-167 csm4 L CRISPR-associated RAMP protein, Csm4 family
MDBCMHFM_00963 2e-205 csm5 L CRISPR-associated RAMP protein, Csm5 family
MDBCMHFM_00965 9.5e-32 csm6 S Psort location Cytoplasmic, score
MDBCMHFM_00966 8e-123 pyrF 4.1.1.23 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
MDBCMHFM_00967 7.5e-112 pyrE 2.4.2.10, 4.1.1.23 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MDBCMHFM_00969 1.6e-266 dtpT E transporter
MDBCMHFM_00970 2.3e-62 yecS P ABC transporter (Permease
MDBCMHFM_00971 2.3e-20 yecS P amino acid transport
MDBCMHFM_00973 2e-272 sasH 3.1.3.5, 3.6.1.45 F Belongs to the 5'-nucleotidase family
MDBCMHFM_00974 9.8e-35 3.1.3.6, 3.1.4.16 F nucleotide catabolic process
MDBCMHFM_00975 1.4e-104 yfiF3 K sequence-specific DNA binding
MDBCMHFM_00976 1.6e-247 mnmE S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MDBCMHFM_00977 1.8e-240 agcS E (Alanine) symporter
MDBCMHFM_00978 0.0 pcrA 3.6.4.12 L ATP-dependent DNA helicase
MDBCMHFM_00979 4.6e-241 metY 2.5.1.49 E o-acetylhomoserine
MDBCMHFM_00980 1.8e-59 Q phosphatase activity
MDBCMHFM_00981 9.3e-62 S haloacid dehalogenase-like hydrolase
MDBCMHFM_00982 3.5e-88 tpx 1.11.1.15 O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
MDBCMHFM_00983 1.1e-110 hsdS2 2.1.1.72 V Type I restriction modification DNA specificity domain
MDBCMHFM_00984 1.7e-96 XK27_04775 S hemerythrin HHE cation binding domain
MDBCMHFM_00985 2.6e-49 XK27_04775 S hemerythrin HHE cation binding domain
MDBCMHFM_00986 4.9e-151 truB 5.4.99.25 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MDBCMHFM_00987 5.3e-175 ribF 2.7.1.26, 2.7.7.2 H Belongs to the ribF family
MDBCMHFM_00988 1.4e-71 spxA 1.20.4.1 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
MDBCMHFM_00989 1.9e-43 yktA S Belongs to the UPF0223 family
MDBCMHFM_00990 5e-142 suhB 3.1.3.25 G Belongs to the inositol monophosphatase superfamily
MDBCMHFM_00991 7.9e-257 rsmF 2.1.1.176, 2.1.1.178 J NOL1 NOP2 sun family protein
MDBCMHFM_00992 3.3e-158 pstS P phosphate
MDBCMHFM_00993 2.5e-156 pstC P probably responsible for the translocation of the substrate across the membrane
MDBCMHFM_00994 1.2e-155 pstA P phosphate transport system permease
MDBCMHFM_00995 1e-150 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
MDBCMHFM_00996 2.3e-139 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
MDBCMHFM_00997 1.9e-113 phoU P Plays a role in the regulation of phosphate uptake
MDBCMHFM_00998 0.0 pepN 3.4.11.2 E aminopeptidase
MDBCMHFM_00999 7e-195 xerS D Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division
MDBCMHFM_01000 7.2e-186 lplA 6.3.1.20 H Lipoate-protein ligase
MDBCMHFM_01001 1.1e-17
MDBCMHFM_01002 3.7e-09
MDBCMHFM_01003 0.0 glgP 2.4.1.1 GT35 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
MDBCMHFM_01004 2.3e-300 malQ 2.4.1.25 GH77 G 4-alpha-glucanotransferase
MDBCMHFM_01005 2.3e-23 L Transposase
MDBCMHFM_01006 4.6e-25 tatA U protein secretion
MDBCMHFM_01007 5.8e-121 tatC U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MDBCMHFM_01008 8.8e-301 ywbL P COG0672 High-affinity Fe2 Pb2 permease
MDBCMHFM_01009 5.6e-233 ycdB P peroxidase
MDBCMHFM_01010 7.1e-153 ycdO P periplasmic lipoprotein involved in iron transport
MDBCMHFM_01011 2e-178 fatB P ABC-type enterochelin transport system, periplasmic component
MDBCMHFM_01012 6.8e-136 yclP 3.6.3.34 P abc transporter atp-binding protein
MDBCMHFM_01013 5.6e-167 fatC P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MDBCMHFM_01014 1e-165 yclN P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MDBCMHFM_01015 1.5e-33 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
MDBCMHFM_01016 3.7e-85 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
MDBCMHFM_01017 1.7e-60 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
MDBCMHFM_01018 7.6e-66 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
MDBCMHFM_01019 1.5e-133 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
MDBCMHFM_01020 2.2e-112 3.5.1.28 M GBS Bsp-like repeat
MDBCMHFM_01021 7.9e-67 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
MDBCMHFM_01022 6.4e-11 3.5.1.28 NU amidase activity
MDBCMHFM_01023 0.0 lpdA 1.8.1.4 C Dehydrogenase
MDBCMHFM_01024 5.4e-200 acoC 2.3.1.12 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
MDBCMHFM_01025 3.7e-182 acoB 1.2.4.1, 1.2.4.4 C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
MDBCMHFM_01026 6e-185 acoA 1.2.4.1, 1.2.4.4 C Dehydrogenase E1 component
MDBCMHFM_01027 3.1e-45 hpk9 2.7.13.3 T protein histidine kinase activity
MDBCMHFM_01028 2.2e-83 2.7.13.3 T protein histidine kinase activity
MDBCMHFM_01029 3.6e-37 2.7.13.3 T protein histidine kinase activity
MDBCMHFM_01030 1.6e-52 2.7.13.3 T protein histidine kinase activity
MDBCMHFM_01031 1.3e-160 cas2 2.7.7.7 L CRISPR-associated endoribonuclease Cas2
MDBCMHFM_01032 5.8e-169 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MDBCMHFM_01033 3.2e-110 casE S CRISPR system CASCADE complex protein CasE
MDBCMHFM_01034 3.6e-134 casD S CRISPR system CASCADE complex protein CasD
MDBCMHFM_01035 5.8e-181 casC L CT1975-like protein
MDBCMHFM_01036 6e-103 casB S CRISPR system CASCADE complex protein CasB
MDBCMHFM_01037 0.0 casA L the current gene model (or a revised gene model) may contain a frame shift
MDBCMHFM_01038 0.0 cas3 L CRISPR-associated helicase cas3
MDBCMHFM_01039 0.0 S the current gene model (or a revised gene model) may contain a frame shift
MDBCMHFM_01040 2.4e-234 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
MDBCMHFM_01041 2.9e-127 ung 3.2.2.27 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MDBCMHFM_01042 1.6e-216 yeaB K Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MDBCMHFM_01043 5.9e-22 dacA1 3.4.16.4 M Belongs to the peptidase S11 family
MDBCMHFM_01044 3.9e-24 3.4.16.4 M Belongs to the peptidase S11 family
MDBCMHFM_01045 2.3e-26 3.4.16.4 M Belongs to the peptidase S11 family
MDBCMHFM_01046 4.3e-83 3.4.16.4 M Belongs to the peptidase S11 family
MDBCMHFM_01047 1.2e-157 rssA S Phospholipase, patatin family
MDBCMHFM_01048 1.8e-69 estA E GDSL-like protein
MDBCMHFM_01049 3.4e-29 estA E Lysophospholipase L1 and related esterases
MDBCMHFM_01050 1.8e-292 S unusual protein kinase
MDBCMHFM_01051 4.9e-39 S granule-associated protein
MDBCMHFM_01052 2.1e-138 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
MDBCMHFM_01053 2e-18 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
MDBCMHFM_01054 1.3e-199 S hmm pf01594
MDBCMHFM_01055 9.5e-89 G Belongs to the phosphoglycerate mutase family
MDBCMHFM_01056 8.4e-69 supH 3.1.3.102, 3.1.3.104 Q phosphatase activity
MDBCMHFM_01057 9.2e-15 supH 3.1.3.102, 3.1.3.104 S Sucrose-6F-phosphate phosphohydrolase
MDBCMHFM_01058 5.8e-95 V VanZ like family
MDBCMHFM_01059 1.4e-201 L Transposase
MDBCMHFM_01060 8.2e-215 glf 5.4.99.9 M UDP-galactopyranose mutase
MDBCMHFM_01061 6e-20 epsU S Polysaccharide biosynthesis protein
MDBCMHFM_01062 1.4e-172 epsU S Polysaccharide biosynthesis protein
MDBCMHFM_01063 1.8e-238 cps1C S Polysaccharide biosynthesis protein
MDBCMHFM_01064 8.7e-88 2.7.8.12 GT2 M Glycosyltransferase like family 2
MDBCMHFM_01065 1.8e-32 ywqD 2.7.10.1 D Capsular exopolysaccharide family
MDBCMHFM_01066 4.8e-102 M group 2 family protein
MDBCMHFM_01067 7.7e-100
MDBCMHFM_01068 1.2e-71 cps1D M Domain of unknown function (DUF4422)
MDBCMHFM_01069 5.6e-62 L Transposase DDE domain
MDBCMHFM_01070 2.7e-73 L Transposase DDE domain
MDBCMHFM_01071 2.7e-23 rgpAc GT4 M group 1 family protein
MDBCMHFM_01072 2.7e-255 cpsE M Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
MDBCMHFM_01074 5.9e-110 cpsD D COG0489 ATPases involved in chromosome partitioning
MDBCMHFM_01075 1.1e-105 cps4C M biosynthesis protein
MDBCMHFM_01076 1.5e-135 cpsB 3.1.3.48 GM Capsular polysaccharide biosynthesis protein
MDBCMHFM_01077 8e-258 cps4A K Cell envelope-like function transcriptional attenuator common domain protein
MDBCMHFM_01078 4.3e-222 L Transposase
MDBCMHFM_01079 2e-129 deoD 2.4.2.1, 2.4.2.28 F purine nucleoside phosphorylase
MDBCMHFM_01080 7e-38 yfeJ 6.3.5.2 F glutamine amidotransferase
MDBCMHFM_01081 3.7e-67 yfeJ 6.3.5.2 F glutamine amidotransferase
MDBCMHFM_01082 4e-64 clcA_2 P chloride
MDBCMHFM_01083 4e-150 punA 2.4.2.1 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MDBCMHFM_01084 8.1e-41 S Protein of unknown function (DUF1697)
MDBCMHFM_01085 8.1e-232 deoB 5.4.2.7 G Phosphotransfer between the C1 and C5 carbon atoms of pentose
MDBCMHFM_01086 1.7e-122 rpiA 2.7.1.12, 2.7.1.15, 5.3.1.6 G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MDBCMHFM_01088 6.1e-22 V Glucan-binding protein C
MDBCMHFM_01089 2.4e-112 ung2 3.2.2.27 L Uracil-DNA glycosylase
MDBCMHFM_01090 8.2e-276 pepV 3.5.1.18 E Dipeptidase
MDBCMHFM_01091 6.4e-27 dmpI 5.3.2.6 G Belongs to the 4-oxalocrotonate tautomerase family
MDBCMHFM_01092 6.9e-86 XK27_03610 K Gnat family
MDBCMHFM_01093 1.5e-32 L Transposase
MDBCMHFM_01094 1.5e-56 rplT J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MDBCMHFM_01095 2.1e-28 rpmI J Belongs to the bacterial ribosomal protein bL35 family
MDBCMHFM_01096 3.5e-86 infC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MDBCMHFM_01097 6.6e-122 cmk 1.17.7.4, 2.5.1.19, 2.7.1.26, 2.7.4.25, 2.7.7.2, 6.3.2.1 F Belongs to the cytidylate kinase family. Type 1 subfamily
MDBCMHFM_01098 3.9e-15 M LysM domain
MDBCMHFM_01099 2.9e-90 ebsA S Family of unknown function (DUF5322)
MDBCMHFM_01100 1.4e-234 pepT 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
MDBCMHFM_01101 4.2e-98 lepB 3.4.21.89 U Belongs to the peptidase S26 family
MDBCMHFM_01102 1.8e-223 G COG0457 FOG TPR repeat
MDBCMHFM_01103 6.2e-176 yubA S permease
MDBCMHFM_01104 4.6e-93 mutX 3.6.1.55 F NTP pyrophosphohydrolases including oxidative damage repair enzymes
MDBCMHFM_01105 3.6e-163 ftsX D Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation
MDBCMHFM_01106 2.5e-124 ftsE D cell division ATP-binding protein FtsE
MDBCMHFM_01107 7.4e-183 prfB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MDBCMHFM_01108 1.2e-202 queG 1.17.99.6 C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MDBCMHFM_01109 4.3e-180 yjjH S Calcineurin-like phosphoesterase
MDBCMHFM_01110 5.2e-136 nfrA 1.5.1.38, 1.5.1.39 C nitroreductase
MDBCMHFM_01111 0.0 pacL 3.6.3.8 P cation transport ATPase
MDBCMHFM_01112 2.6e-67 ywiB S Domain of unknown function (DUF1934)
MDBCMHFM_01113 3.6e-45 XK27_00115 2.3.1.128 K acetyltransferase
MDBCMHFM_01114 9.2e-147 yidA S hydrolases of the HAD superfamily
MDBCMHFM_01115 9e-231 murM 2.3.2.10, 2.3.2.16 V protein involved in methicillin resistance
MDBCMHFM_01116 5e-35 F Protein of unknown function (DUF454)
MDBCMHFM_01117 1e-153 vicX 3.1.26.11 S Metal-dependent hydrolases of the beta-lactamase superfamily I
MDBCMHFM_01118 1.5e-247 vicK 2.7.13.3 T Histidine kinase
MDBCMHFM_01119 9.9e-129 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MDBCMHFM_01120 2.1e-140 glnQ 3.6.3.21 E abc transporter atp-binding protein
MDBCMHFM_01121 3.1e-150 peb1A ET ABC-type amino acid transport signal transduction systems, periplasmic component domain
MDBCMHFM_01122 5.9e-118 gltJ P ABC transporter (Permease
MDBCMHFM_01123 5e-111 tcyB_2 P ABC transporter (permease)
MDBCMHFM_01124 2.4e-124 endA F DNA RNA non-specific endonuclease
MDBCMHFM_01125 1.2e-25 epuA S DNA-directed RNA polymerase subunit beta
MDBCMHFM_01126 1.1e-231 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MDBCMHFM_01128 6e-196 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
MDBCMHFM_01129 8.3e-28 G Domain of unknown function (DUF4832)
MDBCMHFM_01130 2.1e-203 metK 2.5.1.6 H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MDBCMHFM_01131 4.2e-175 birA 6.3.4.15 HK Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
MDBCMHFM_01132 3.2e-295 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MDBCMHFM_01133 1.6e-88 ytsP 1.8.4.14 T GAF domain-containing protein
MDBCMHFM_01134 1.9e-164 miaA 2.5.1.75 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MDBCMHFM_01135 2.1e-19 WQ51_02665 S Protein of unknown function (DUF3042)
MDBCMHFM_01138 8.5e-57 rplS J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
MDBCMHFM_01139 2.1e-219 XK27_05110 P chloride
MDBCMHFM_01140 8.7e-41 pheA 1.3.1.12, 2.3.1.79, 4.2.1.51, 5.4.99.5 E Chorismate mutase
MDBCMHFM_01141 6.4e-282 clcA P Chloride transporter, ClC family
MDBCMHFM_01142 2.3e-75 fld C Flavodoxin
MDBCMHFM_01144 4.7e-126 XK27_08875 O Zinc-dependent metalloprotease
MDBCMHFM_01145 3.5e-151 estA CE1 S Putative esterase
MDBCMHFM_01146 3.5e-310 rnjB S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MDBCMHFM_01147 1.2e-135 XK27_08845 S abc transporter atp-binding protein
MDBCMHFM_01148 4e-148 XK27_08840 S Belongs to the binding-protein-dependent transport system permease family
MDBCMHFM_01149 3.3e-178 XK27_08835 S ABC transporter substrate binding protein
MDBCMHFM_01150 1.6e-16 S Domain of unknown function (DUF4649)
MDBCMHFM_01152 6.9e-41 Q the current gene model (or a revised gene model) may contain a frame shift
MDBCMHFM_01153 2.7e-26 Q the current gene model (or a revised gene model) may contain a frame shift
MDBCMHFM_01154 3.2e-09 Q the current gene model (or a revised gene model) may contain a frame shift
MDBCMHFM_01156 1.6e-249 L Transposase
MDBCMHFM_01157 1.1e-278 pyk 2.7.1.40, 2.7.7.4 G Belongs to the pyruvate kinase family
MDBCMHFM_01158 1.2e-188 pfkA 2.7.1.11 F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
MDBCMHFM_01159 0.0 dnaE 2.7.7.7 L DNA polymerase
MDBCMHFM_01160 3.2e-152 sua5 2.7.7.87 J Belongs to the SUA5 family
MDBCMHFM_01161 3.1e-112 leuD 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MDBCMHFM_01162 6.8e-275 leuC 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MDBCMHFM_01163 2.5e-43 ysdA L Membrane
MDBCMHFM_01164 6.6e-190 leuB 1.1.1.85 CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
MDBCMHFM_01165 3.4e-291 leuA 2.3.3.13 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MDBCMHFM_01166 4.6e-131 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MDBCMHFM_01167 2.5e-180 pyrD 1.3.1.14, 1.3.98.1 F Catalyzes the conversion of dihydroorotate to orotate
MDBCMHFM_01169 2.8e-39 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
MDBCMHFM_01170 2.1e-84 ypmS S Protein conserved in bacteria
MDBCMHFM_01171 6e-144 ypmR E lipolytic protein G-D-S-L family
MDBCMHFM_01172 1e-148 DegV S DegV family
MDBCMHFM_01173 5.8e-305 recN L May be involved in recombinational repair of damaged DNA
MDBCMHFM_01174 1.8e-72 argR K Regulates arginine biosynthesis genes
MDBCMHFM_01175 5e-159 rrmJ 2.1.1.226, 2.1.1.227 J Ribosomal RNA large subunit methyltransferase J
MDBCMHFM_01176 1.5e-158 ispA 2.5.1.1, 2.5.1.10, 2.5.1.29, 2.5.1.90 H Belongs to the FPP GGPP synthase family
MDBCMHFM_01177 3.5e-29 xseB 3.1.11.6 L exodeoxyribonuclease VII activity
MDBCMHFM_01178 1.2e-247 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
MDBCMHFM_01180 3.4e-120 nth 4.2.99.18 L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MDBCMHFM_01181 2.9e-125 dnaD
MDBCMHFM_01182 9.3e-183 metA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MDBCMHFM_01183 2e-94 apt 2.4.2.22, 2.4.2.7 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MDBCMHFM_01184 0.0 recJ L Single-strand DNA-specific exonuclease, C terminal domain
MDBCMHFM_01185 6.7e-139 XK27_05435 1.1.1.100 S Belongs to the short-chain dehydrogenases reductases (SDR) family
MDBCMHFM_01186 9.2e-175 rnz 3.1.26.11 S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
MDBCMHFM_01187 4.2e-118 galT 2.7.7.12 G UDPglucose--hexose-1-phosphate uridylyltransferase
MDBCMHFM_01188 1.4e-223 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MDBCMHFM_01189 5.4e-197 L transposase, IS4 family
MDBCMHFM_01190 5.6e-240 rodA D Belongs to the SEDS family
MDBCMHFM_01191 1.8e-50 hisE 3.5.4.19, 3.6.1.31, 5.3.1.16 E Phosphoribosyl-ATP
MDBCMHFM_01192 5.5e-61 hisI 3.5.4.19, 3.5.4.25, 3.6.1.31, 5.3.1.16 E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MDBCMHFM_01193 9.6e-138 hisF 3.5.4.19, 3.6.1.31 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
MDBCMHFM_01194 1.7e-131 hisA 5.3.1.16 E 1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MDBCMHFM_01195 3.2e-112 hisH E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MDBCMHFM_01196 3.9e-107 hisB 1.1.1.23, 2.6.1.9, 3.1.3.15, 4.2.1.19 E imidazoleglycerol-phosphate dehydratase
MDBCMHFM_01197 1.1e-234 hisD 1.1.1.23, 1.1.1.308 E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MDBCMHFM_01198 2.7e-117 hisG 2.4.2.17 E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
MDBCMHFM_01199 1.5e-183 hisZ 2.4.2.17, 6.1.1.21 E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
MDBCMHFM_01200 1.5e-197 hisC 2.6.1.9 E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MDBCMHFM_01202 6.6e-31 L Integrase core domain protein
MDBCMHFM_01203 1.6e-55 L transposition
MDBCMHFM_01204 2.5e-23 L Transposase
MDBCMHFM_01205 5.2e-36 L transposase activity
MDBCMHFM_01206 1.3e-22 XK27_08085
MDBCMHFM_01207 5.6e-92 XK27_08080 3.1.1.53 G Exopolysaccharide biosynthesis protein
MDBCMHFM_01208 2.3e-09 XK27_08080 3.1.1.53 G Exopolysaccharide biosynthesis protein
MDBCMHFM_01209 2e-140 hisK 3.1.3.15 E Histidinol phosphatase and related hydrolases of the PHP family
MDBCMHFM_01210 1.1e-121 ylfI S tigr01906
MDBCMHFM_01211 5.9e-143 nagD 2.7.1.25, 3.1.3.41 G Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
MDBCMHFM_01212 1.5e-143 fat 3.1.2.21 I Acyl-ACP thioesterase
MDBCMHFM_01213 4.1e-217 hemN H Involved in the biosynthesis of porphyrin-containing compound
MDBCMHFM_01216 3.5e-238 L Transposase
MDBCMHFM_01217 1.9e-205 rfbB 4.2.1.46 M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
MDBCMHFM_01218 8.3e-113 rmlC 1.1.1.133, 5.1.3.13 M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
MDBCMHFM_01219 2.4e-161 rfbA 2.7.7.24 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MDBCMHFM_01220 9e-206 yurR 1.4.5.1 E oxidoreductase
MDBCMHFM_01221 6.4e-29 zupT P transporter
MDBCMHFM_01222 1.1e-13 zupT P Mediates zinc uptake. May also transport other divalent cations
MDBCMHFM_01223 9.6e-149 yqfO 3.5.4.16 S Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MDBCMHFM_01224 2.7e-123 trmK 2.1.1.217 S SAM-dependent methyltransferase
MDBCMHFM_01225 1.7e-70 gtrA S GtrA-like protein
MDBCMHFM_01226 1.5e-250 glmM 5.4.2.10 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MDBCMHFM_01227 6e-169 ybbR S Protein conserved in bacteria
MDBCMHFM_01228 5.6e-124 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MDBCMHFM_01229 7.5e-255 murD 3.4.21.10, 6.3.2.13, 6.3.2.9 M Mur ligase, middle domain protein
MDBCMHFM_01230 8.7e-150 cobQ S glutamine amidotransferase
MDBCMHFM_01231 0.0 mprF 2.3.2.3 J Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MDBCMHFM_01232 2.2e-131 pip 1.11.1.10 S Alpha beta hydrolase
MDBCMHFM_01233 0.0 uup S abc transporter atp-binding protein
MDBCMHFM_01234 2.1e-114 udk 2.7.1.48 F Cytidine monophosphokinase
MDBCMHFM_01235 2.7e-178 yfmL 3.6.4.13 L DEAD DEAH box helicase
MDBCMHFM_01236 2.1e-28 6.3.2.2, 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
MDBCMHFM_01237 8.6e-265 gapN 1.2.1.9 C Belongs to the aldehyde dehydrogenase family
MDBCMHFM_01238 1.6e-249 L Transposase
MDBCMHFM_01239 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MDBCMHFM_01240 7.9e-39 ptsH G phosphocarrier protein Hpr
MDBCMHFM_01241 7.4e-222 icd 1.1.1.42 C Isocitrate dehydrogenase
MDBCMHFM_01242 6.7e-212 citZ 2.3.3.1 C Belongs to the citrate synthase family
MDBCMHFM_01243 0.0 acnA 4.2.1.3 C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MDBCMHFM_01244 2.2e-34 nrdH O Glutaredoxin
MDBCMHFM_01245 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MDBCMHFM_01246 1.7e-184 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MDBCMHFM_01248 4.2e-71 L Transposase (IS116 IS110 IS902 family)
MDBCMHFM_01249 3.3e-26 L Transposase (IS116 IS110 IS902 family)
MDBCMHFM_01250 6.9e-165 ypuA S secreted protein
MDBCMHFM_01251 8.3e-51 yaeR E COG0346 LactoylglutaTHIone lyase and related lyases
MDBCMHFM_01252 8.7e-131 srtA 3.4.22.70 M Sortase (surface protein transpeptidase)
MDBCMHFM_01253 0.0 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MDBCMHFM_01254 1.1e-181 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
MDBCMHFM_01255 3.4e-258 noxE P NADH oxidase
MDBCMHFM_01256 1.9e-294 yfmM S abc transporter atp-binding protein
MDBCMHFM_01257 3.3e-82 XK27_01265 S ECF-type riboflavin transporter, S component
MDBCMHFM_01258 8.7e-85 pdxK 2.7.1.35 H Belongs to the pyridoxine kinase family
MDBCMHFM_01259 4.5e-44 pdxK 2.7.1.35 H Belongs to the pyridoxine kinase family
MDBCMHFM_01260 2e-86 S ECF-type riboflavin transporter, S component
MDBCMHFM_01262 5e-240 XK27_08130 K Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
MDBCMHFM_01263 2e-55 nrdD_1 1.1.98.6, 1.17.4.1 F Ribonucleoside-triphosphate reductase
MDBCMHFM_01266 0.0 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
MDBCMHFM_01267 9.9e-94 paiA 2.3.1.57 K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
MDBCMHFM_01268 1.1e-197 pheS 6.1.1.20 J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MDBCMHFM_01269 0.0 smc D Required for chromosome condensation and partitioning
MDBCMHFM_01270 8.4e-125 rnc 3.1.26.3 J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
MDBCMHFM_01271 6.6e-173 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MDBCMHFM_01272 1.1e-198 asd 1.2.1.11 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MDBCMHFM_01273 2.4e-92 pat 2.3.1.183 M acetyltransferase
MDBCMHFM_01274 3e-13
MDBCMHFM_01275 8.9e-30
MDBCMHFM_01276 9e-278 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MDBCMHFM_01277 0.0 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
MDBCMHFM_01278 5.1e-130 yjjG 3.1.3.102, 3.1.3.104, 3.1.3.5, 3.8.1.2 E hydrolase
MDBCMHFM_01279 3.8e-122 sdaAB 4.3.1.17 E L-serine dehydratase
MDBCMHFM_01280 6.9e-30 sdaAA 4.3.1.17 E L-serine dehydratase
MDBCMHFM_01281 4e-102 sdaAA 4.3.1.17 E L-serine dehydratase
MDBCMHFM_01282 7.4e-26
MDBCMHFM_01283 7.6e-146 S ABC-2 family transporter protein
MDBCMHFM_01284 1.1e-98 S transport system, permease component
MDBCMHFM_01285 4.4e-101 desR K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MDBCMHFM_01286 2.6e-192 desK 2.7.13.3 T Histidine kinase
MDBCMHFM_01287 1.4e-133 yvfS V ABC-2 type transporter
MDBCMHFM_01288 9.7e-158 XK27_09825 V abc transporter atp-binding protein
MDBCMHFM_01292 2.3e-213 EGP Major facilitator Superfamily
MDBCMHFM_01293 0.0 2.7.7.73, 2.7.7.80 E metalloendopeptidase activity
MDBCMHFM_01294 1.2e-152 mutR K Transcriptional activator, Rgg GadR MutR family
MDBCMHFM_01295 3.9e-41 3.6.1.55 F NUDIX domain
MDBCMHFM_01297 3.7e-122 S An automated process has identified a potential problem with this gene model
MDBCMHFM_01298 6.1e-26 XK27_09825 V 'abc transporter, ATP-binding protein
MDBCMHFM_01299 1.4e-15 liaI KT membrane
MDBCMHFM_01300 2.6e-30 liaI KT membrane
MDBCMHFM_01301 4.7e-93 XK27_05000 S Fe-S-cluster oxidoreductase
MDBCMHFM_01302 0.0 V ABC transporter (permease)
MDBCMHFM_01303 5.8e-135 macB2 V ABC transporter, ATP-binding protein
MDBCMHFM_01304 1e-163 T Histidine kinase
MDBCMHFM_01305 4.6e-123 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MDBCMHFM_01306 5.9e-77 xpt 2.4.2.22, 2.4.2.7 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
MDBCMHFM_01307 3.3e-69 pbuX F xanthine permease
MDBCMHFM_01308 9.2e-119 pbuX F xanthine permease
MDBCMHFM_01309 1e-246 norM V Multidrug efflux pump
MDBCMHFM_01310 2.8e-187 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MDBCMHFM_01311 1.3e-235 brnQ E Component of the transport system for branched-chain amino acids
MDBCMHFM_01312 9.4e-65 manA 5.3.1.8 G mannose-6-phosphate isomerase
MDBCMHFM_01313 8.2e-57 manA 5.3.1.8 G mannose-6-phosphate isomerase
MDBCMHFM_01314 4.8e-25 csbD K CsbD-like
MDBCMHFM_01315 6.2e-228 yfnA E amino acid
MDBCMHFM_01316 5.1e-110 XK27_02070 S nitroreductase
MDBCMHFM_01317 9.5e-150 1.13.11.2 S glyoxalase
MDBCMHFM_01318 5.6e-77 ywnA K Transcriptional regulator
MDBCMHFM_01319 9.5e-158 E Alpha/beta hydrolase of unknown function (DUF915)
MDBCMHFM_01320 1.9e-231 pts13C G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
MDBCMHFM_01321 1.4e-110 drgA C Nitroreductase
MDBCMHFM_01322 3e-102 yoaK S Protein of unknown function (DUF1275)
MDBCMHFM_01323 1.2e-160 yvgN C reductase
MDBCMHFM_01324 1e-181 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
MDBCMHFM_01325 1.5e-283 XK27_07020 S Belongs to the UPF0371 family
MDBCMHFM_01327 4.8e-55 K response regulator
MDBCMHFM_01328 9.3e-72 S Signal peptide protein, YSIRK family
MDBCMHFM_01329 4.5e-61
MDBCMHFM_01330 5.5e-272 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MDBCMHFM_01331 1.9e-35
MDBCMHFM_01332 5.3e-12 IQ PFAM AMP-dependent synthetase and ligase
MDBCMHFM_01333 2.7e-12 IQ PFAM AMP-dependent synthetase and ligase
MDBCMHFM_01334 5.8e-109 MA20_06410 E LysE type translocator
MDBCMHFM_01335 5.6e-08
MDBCMHFM_01336 2.7e-09
MDBCMHFM_01337 0.0 M family 8
MDBCMHFM_01339 2.8e-164 hrtB V MacB-like periplasmic core domain
MDBCMHFM_01340 1.3e-117 devA 3.6.3.25 V abc transporter atp-binding protein
MDBCMHFM_01341 1.1e-151 V MatE
MDBCMHFM_01343 1.5e-109 C Fe-S oxidoreductases
MDBCMHFM_01344 1.2e-176 EGP Major Facilitator Superfamily
MDBCMHFM_01345 1.7e-229 I radical SAM domain protein
MDBCMHFM_01346 4.3e-19 I radical SAM domain protein
MDBCMHFM_01348 6.5e-159 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
MDBCMHFM_01349 1.5e-149 L Integrase core domain protein
MDBCMHFM_01350 6.1e-18 L transposase activity
MDBCMHFM_01351 8.1e-54 L transposase activity
MDBCMHFM_01353 3.9e-92
MDBCMHFM_01354 0.0 sbcC L ATPase involved in DNA repair
MDBCMHFM_01355 6.9e-231 sbcD L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
MDBCMHFM_01356 0.0 lacL 3.2.1.23 G -beta-galactosidase
MDBCMHFM_01357 0.0 lacS G transporter
MDBCMHFM_01358 2.6e-202 galM 5.1.3.3 G Catalyzes the interconversion of alpha and beta anomers of maltose
MDBCMHFM_01359 6.6e-195 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
MDBCMHFM_01360 8e-290 galT 2.7.7.12 G UDPglucose--hexose-1-phosphate uridylyltransferase
MDBCMHFM_01361 6.9e-220 galK 2.7.1.6 G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MDBCMHFM_01362 2.3e-184 galR K Transcriptional regulator
MDBCMHFM_01363 2.7e-08 L Integrase core domain protein
MDBCMHFM_01364 1.2e-25 L transposition
MDBCMHFM_01365 3.5e-228 zmpB M M26 IgA1-specific Metallo-endopeptidase C-terminal region
MDBCMHFM_01366 6.7e-17 rtxA M M26 IgA1-specific Metallo-endopeptidase C-terminal region
MDBCMHFM_01367 2.5e-101 V abc transporter atp-binding protein
MDBCMHFM_01368 4.3e-40 V abc transporter atp-binding protein
MDBCMHFM_01369 0.0 gshF 6.3.2.2, 6.3.2.29, 6.3.2.30, 6.3.2.4 H Belongs to the glutamate--cysteine ligase type 1 family
MDBCMHFM_01370 6.4e-62 L Transposase
MDBCMHFM_01371 7e-150 pulA 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
MDBCMHFM_01372 1.8e-33 pulA 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
MDBCMHFM_01373 1.7e-120 pulA 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
MDBCMHFM_01374 0.0 ftsK D Belongs to the FtsK SpoIIIE SftA family
MDBCMHFM_01375 5.9e-188 trxB1 1.18.1.2, 1.19.1.1 C Ferredoxin--NADP reductase
MDBCMHFM_01376 7.2e-135 trmD 2.1.1.228, 4.6.1.12 J Belongs to the RNA methyltransferase TrmD family
MDBCMHFM_01377 5.8e-94 rimM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MDBCMHFM_01380 2.2e-114 vraR K Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MDBCMHFM_01381 5.8e-175 vraS 2.7.13.3 T Histidine kinase
MDBCMHFM_01382 3.7e-120 yvqF KT membrane
MDBCMHFM_01383 7e-307 prkC 2.7.11.1 KLT serine threonine protein kinase
MDBCMHFM_01384 2e-132 stp 3.1.3.16 T phosphatase
MDBCMHFM_01385 4.4e-247 sun 2.1.1.176 J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MDBCMHFM_01386 2.5e-172 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MDBCMHFM_01387 0.0 priA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MDBCMHFM_01388 2.7e-46 rpoZ 2.7.7.6 K DNA-directed 5'-3' RNA polymerase activity
MDBCMHFM_01389 9.8e-112 gmk 2.7.4.8 F Essential for recycling GMP and indirectly, cGMP
MDBCMHFM_01390 2.8e-212 ftsY U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
MDBCMHFM_01391 6.9e-150 XK27_02985 S overlaps another CDS with the same product name
MDBCMHFM_01392 2.1e-148 supH S overlaps another CDS with the same product name
MDBCMHFM_01393 8.6e-63 yvoA_1 K Transcriptional
MDBCMHFM_01394 2.8e-120 skfE V abc transporter atp-binding protein
MDBCMHFM_01395 3.3e-133 V ATPase activity
MDBCMHFM_01396 4.3e-172 oppF P Belongs to the ABC transporter superfamily
MDBCMHFM_01397 2.2e-204 oppD P Belongs to the ABC transporter superfamily
MDBCMHFM_01398 4.9e-168 amiD P ABC transporter (Permease
MDBCMHFM_01399 4.2e-278 amiC P ABC transporter (Permease
MDBCMHFM_01400 0.0 amiA E ABC transporter, substrate-binding protein, family 5
MDBCMHFM_01401 1.7e-140 L Transposase
MDBCMHFM_01402 0.0 amiA E ABC transporter, substrate-binding protein, family 5
MDBCMHFM_01403 8.1e-45 L Transposase
MDBCMHFM_01404 4.1e-158 L COG2801 Transposase and inactivated derivatives
MDBCMHFM_01405 2.2e-82 oppF P Belongs to the ABC transporter superfamily
MDBCMHFM_01406 1.4e-40 tatD L Hydrolase, tatd
MDBCMHFM_01407 6.7e-218 oxlT P COG0477 Permeases of the major facilitator superfamily
MDBCMHFM_01408 1e-94 L Integrase core domain protein
MDBCMHFM_01409 1.9e-78 L Transposase
MDBCMHFM_01410 1.4e-181 pta 2.3.1.8, 3.6.3.21 C phosphate acetyltransferase
MDBCMHFM_01411 8.3e-173 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 J Responsible for synthesis of pseudouridine from uracil
MDBCMHFM_01412 5.4e-150 nadK 2.7.1.23 H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MDBCMHFM_01413 5.5e-121 yjbM 2.7.6.5 S Gtp pyrophosphokinase
MDBCMHFM_01414 1.5e-103 yjbK S Adenylate cyclase
MDBCMHFM_01415 2.1e-177 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MDBCMHFM_01416 7e-206 iscS 2.8.1.7 E Cysteine desulfurase
MDBCMHFM_01417 2e-58 XK27_04120 S Putative amino acid metabolism
MDBCMHFM_01418 6.2e-117 rex K Modulates transcription in response to changes in cellular NADH NAD( ) redox state
MDBCMHFM_01419 3.9e-130 puuD T peptidase C26
MDBCMHFM_01420 2.4e-119 radC E Belongs to the UPF0758 family
MDBCMHFM_01421 0.0 rgpF M Rhamnan synthesis protein F
MDBCMHFM_01422 1.1e-179 rgpEc GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
MDBCMHFM_01423 8.7e-226 rgpD 3.6.3.38 P Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system
MDBCMHFM_01424 1.4e-142 rgpC GM Transport permease protein
MDBCMHFM_01425 1.4e-178 rgpB GT2 M Glycosyltransferase, group 2 family protein
MDBCMHFM_01426 1.2e-224 rgpA GT4 M Domain of unknown function (DUF1972)
MDBCMHFM_01427 6e-139 S Predicted membrane protein (DUF2142)
MDBCMHFM_01428 1.6e-127 2.7.8.12 M transferase activity, transferring glycosyl groups
MDBCMHFM_01429 1.8e-213 amrA S polysaccharide biosynthetic process
MDBCMHFM_01430 5.3e-48 XK27_09090 S Uncharacterized conserved protein (DUF2304)
MDBCMHFM_01431 1.9e-124 ycbB S Glycosyl transferase family 2
MDBCMHFM_01432 4e-161 rfbD 1.1.1.133, 5.1.3.13 M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
MDBCMHFM_01433 4.1e-245
MDBCMHFM_01434 4e-170 yfdH GT2 M COG0463, glycosyltransferases involved in cell wall biogenesis
MDBCMHFM_01435 1.3e-54 yitW K metal-sulfur cluster biosynthetic enzyme
MDBCMHFM_01436 1.1e-201 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
MDBCMHFM_01437 0.0 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
MDBCMHFM_01438 5.5e-20 rpsU J Belongs to the bacterial ribosomal protein bS21 family
MDBCMHFM_01439 1.6e-135 gltS ET Belongs to the bacterial solute-binding protein 3 family
MDBCMHFM_01440 4e-201 arcT 2.6.1.1 E Aminotransferase
MDBCMHFM_01441 9.4e-136 ET ABC transporter
MDBCMHFM_01442 3.7e-143 ET Belongs to the bacterial solute-binding protein 3 family
MDBCMHFM_01443 2.9e-84 mutT 3.6.1.55 F Nudix family
MDBCMHFM_01444 0.0 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
MDBCMHFM_01446 1.2e-55 V CAAX protease self-immunity
MDBCMHFM_01447 7.6e-32 S CAAX amino terminal protease family protein
MDBCMHFM_01448 0.0 glnP P ABC-type amino acid transport signal transduction systems periplasmic component domain
MDBCMHFM_01449 1.8e-136 glnQ 3.6.3.21 E abc transporter atp-binding protein
MDBCMHFM_01450 1.1e-16 XK27_00735
MDBCMHFM_01451 1.4e-248 obg S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MDBCMHFM_01453 7.3e-135 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
MDBCMHFM_01456 5.5e-65 paaI Q protein possibly involved in aromatic compounds catabolism
MDBCMHFM_01457 6.6e-30 ycaO O OsmC-like protein
MDBCMHFM_01459 1.7e-154 EG Permeases of the drug metabolite transporter (DMT) superfamily
MDBCMHFM_01461 5.6e-110 csn2 S CRISPR-associated protein (Cas_Csn2)
MDBCMHFM_01462 3.5e-52 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MDBCMHFM_01463 1.5e-163 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MDBCMHFM_01464 0.0 cas9 L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
MDBCMHFM_01465 6.7e-116 serB 3.1.3.3 E phosphoserine phosphatase
MDBCMHFM_01466 3.2e-298 ezrA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
MDBCMHFM_01467 0.0 gyrB 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MDBCMHFM_01468 2.6e-109 3.1.3.18 S IA, variant 1
MDBCMHFM_01469 2.5e-116 lrgB M effector of murein hydrolase
MDBCMHFM_01470 7.7e-56 lrgA S Effector of murein hydrolase LrgA
MDBCMHFM_01472 6.4e-60 arsC 1.20.4.1 P Belongs to the ArsC family
MDBCMHFM_01473 3.1e-56 ogt 2.1.1.63, 3.2.2.20 L methylated-DNA-[protein]-cysteine S-methyltransferase activity
MDBCMHFM_01474 7e-220 serA 1.1.1.399, 1.1.1.95 EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MDBCMHFM_01475 3.9e-104 wecD M Acetyltransferase GNAT family
MDBCMHFM_01476 1.3e-209 serC 2.6.1.52 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MDBCMHFM_01477 5.1e-96 GK ROK family
MDBCMHFM_01478 8.1e-72 gloA 4.4.1.5 E Lactoylglutathione lyase
MDBCMHFM_01479 5.1e-47 XK27_08050 O stress-induced mitochondrial fusion
MDBCMHFM_01480 1.3e-19 XK27_08050 O HflC and HflK could regulate a protease
MDBCMHFM_01481 2.3e-206 potD P spermidine putrescine ABC transporter
MDBCMHFM_01482 3e-134 potC P ABC-type spermidine putrescine transport system, permease component II
MDBCMHFM_01483 3.7e-140 potB P ABC-type spermidine putrescine transport system, permease component I
MDBCMHFM_01484 6.2e-213 potA 3.6.3.30, 3.6.3.31 P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
MDBCMHFM_01485 7.8e-171 murB 1.3.1.98 M cell wall formation
MDBCMHFM_01486 2.9e-87 folK 2.7.6.3, 4.1.2.25 H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MDBCMHFM_01487 1.2e-61 folB 1.13.11.81, 2.5.1.15, 2.7.6.3, 4.1.2.25, 5.1.99.8 H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MDBCMHFM_01488 1.2e-298 amy 3.2.1.1 GH13 G Belongs to the glycosyl hydrolase 13 family
MDBCMHFM_01489 7e-147 folP 2.5.1.15, 2.7.6.3 H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MDBCMHFM_01490 1e-99 folE 3.5.4.16 F gtp cyclohydrolase
MDBCMHFM_01491 0.0 ydaO E amino acid
MDBCMHFM_01492 5.5e-239 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
MDBCMHFM_01493 4.1e-37 ylqC L Belongs to the UPF0109 family
MDBCMHFM_01494 2.4e-43 rpsP J Belongs to the bacterial ribosomal protein bS16 family
MDBCMHFM_01495 2e-171 tehB 2.1.1.265 PQ tellurite resistance protein tehb
MDBCMHFM_01496 2.6e-157 xth 3.1.11.2 L exodeoxyribonuclease III
MDBCMHFM_01497 2.1e-74 S QueT transporter
MDBCMHFM_01498 2.5e-08 ribD 1.1.1.193, 3.5.4.26 L Transposase DDE domain
MDBCMHFM_01499 1.1e-89 ribD 1.1.1.193, 3.5.4.26 L Transposase DDE domain
MDBCMHFM_01500 5.7e-186 yegS 2.7.1.107 I Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
MDBCMHFM_01501 0.0 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MDBCMHFM_01502 3.7e-85 ccl S cog cog4708
MDBCMHFM_01503 4.9e-160 rbn E Belongs to the UPF0761 family
MDBCMHFM_01504 1.5e-166 map 3.4.11.18 E Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed
MDBCMHFM_01505 3.3e-231 ytoI K transcriptional regulator containing CBS domains
MDBCMHFM_01506 2.4e-98 XK27_07830 2.3.1.128 J Acetyltransferase GNAT Family
MDBCMHFM_01507 1e-232 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MDBCMHFM_01508 0.0 comEC S Competence protein ComEC
MDBCMHFM_01509 3e-98 comEA L COG1555 DNA uptake protein and related DNA-binding proteins
MDBCMHFM_01510 1.7e-142 plsC 2.3.1.51 I Acyltransferase
MDBCMHFM_01511 1.8e-140 nodB3 G deacetylase
MDBCMHFM_01512 7.1e-141 yabB 2.1.1.223 L Methyltransferase
MDBCMHFM_01513 1e-41 yazA L endonuclease containing a URI domain
MDBCMHFM_01514 6.9e-239 cshA 3.6.4.13 JKL DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
MDBCMHFM_01515 5.7e-153 corA P CorA-like protein
MDBCMHFM_01516 1.9e-62 yjqA S Bacterial PH domain
MDBCMHFM_01517 7.8e-100 thiT S Thiamine transporter
MDBCMHFM_01518 2.1e-157 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
MDBCMHFM_01519 1.9e-201 yjbB G Permeases of the major facilitator superfamily
MDBCMHFM_01520 3.1e-300 prfC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MDBCMHFM_01521 1.4e-121 ywaF S Integral membrane protein (intg_mem_TP0381)
MDBCMHFM_01522 3e-259 murF 6.3.2.10 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
MDBCMHFM_01526 1.1e-155 cjaA ET ABC transporter substrate-binding protein
MDBCMHFM_01527 1.4e-136 glnQ 3.6.3.21 E abc transporter atp-binding protein
MDBCMHFM_01528 1.3e-114 P ABC transporter (Permease
MDBCMHFM_01529 1e-114 papP P ABC transporter (Permease
MDBCMHFM_01530 1.7e-193 ddl 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
MDBCMHFM_01531 4.7e-31 copZ 2.7.7.77 P Heavy metal-associated domain protein
MDBCMHFM_01532 0.0 copA 3.6.3.54 P P-type ATPase
MDBCMHFM_01533 2.7e-73 copY K Copper transport repressor, CopY TcrY family
MDBCMHFM_01534 2.1e-143 trpA 4.2.1.20 E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
MDBCMHFM_01535 5.4e-228 trpB 4.2.1.20, 5.3.1.24 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
MDBCMHFM_01536 8.8e-99 trpF 4.1.1.48, 4.2.1.160, 4.2.1.20, 5.3.1.24 E belongs to the TrpF family
MDBCMHFM_01537 2.5e-133 trpC 4.1.1.48, 5.3.1.24 E Belongs to the TrpC family
MDBCMHFM_01538 7.8e-180 trpD 2.4.2.18, 4.1.3.27 F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MDBCMHFM_01539 3.6e-105 trpG 2.4.2.18, 2.6.1.85, 4.1.3.27 EH anthranilate
MDBCMHFM_01540 6.9e-256 trpE 4.1.3.27 EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MDBCMHFM_01541 8.1e-42 pchB 2.5.1.19, 4.2.1.10, 4.2.99.21, 5.4.99.5 E Chorismate mutase
MDBCMHFM_01542 1.4e-54
MDBCMHFM_01543 0.0 ctpE P E1-E2 ATPase
MDBCMHFM_01544 3.9e-26
MDBCMHFM_01545 1.2e-43 yaaK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MDBCMHFM_01546 9.7e-28 L transposase activity
MDBCMHFM_01547 2.7e-129 K transcriptional regulator, MerR family
MDBCMHFM_01548 1.4e-104 dnaQ 2.7.7.7 L DNA polymerase III
MDBCMHFM_01549 1.2e-41 WQ51_02910 S Protein of unknown function, DUF536
MDBCMHFM_01550 4.8e-63 XK27_02560 S cog cog2151
MDBCMHFM_01551 0.0 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
MDBCMHFM_01552 7.7e-227 ytfP S Flavoprotein
MDBCMHFM_01554 3.1e-121 trmB 2.1.1.297, 2.1.1.33 J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
MDBCMHFM_01555 1.2e-151 ytmP 2.7.1.89 M Phosphotransferase
MDBCMHFM_01556 2.7e-183 ecsB U ABC transporter
MDBCMHFM_01557 2.3e-133 ecsA V abc transporter atp-binding protein
MDBCMHFM_01558 3.9e-72 hit FG Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
MDBCMHFM_01559 5.6e-12
MDBCMHFM_01560 2.6e-55 S CD20-like family
MDBCMHFM_01561 7.3e-107
MDBCMHFM_01562 0.0 clpL O ATP-dependent Clp protease ATP-binding subunit
MDBCMHFM_01563 6.9e-206 ylbM S Belongs to the UPF0348 family
MDBCMHFM_01564 2e-140 yqeM Q Methyltransferase domain protein
MDBCMHFM_01565 6e-58 rsfS J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
MDBCMHFM_01566 1.4e-107 nadD 2.7.6.3, 2.7.7.18 H HD superfamily hydrolase involved in NAD metabolism
MDBCMHFM_01567 3.1e-118 nadD 2.7.7.18, 3.6.1.55 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MDBCMHFM_01568 3.5e-49 yhbY J RNA-binding protein
MDBCMHFM_01569 1.7e-215 yqeH S in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis
MDBCMHFM_01570 1.8e-98 yqeG S hydrolase of the HAD superfamily
MDBCMHFM_01571 2.6e-153 yicL EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
MDBCMHFM_01572 1.3e-57
MDBCMHFM_01573 2.3e-273 gatB 6.1.1.12, 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MDBCMHFM_01574 3.5e-269 gatA 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
MDBCMHFM_01575 1.4e-47 gatC 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MDBCMHFM_01576 6.3e-31 M lipopolysaccharide 3-alpha-galactosyltransferase activity
MDBCMHFM_01577 4.4e-255 ascB 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
MDBCMHFM_01578 4.7e-96 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MDBCMHFM_01579 4.8e-154 hlpA M Belongs to the NlpA lipoprotein family
MDBCMHFM_01580 6.8e-101 pncA Q isochorismatase
MDBCMHFM_01581 1.2e-140 codY K DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
MDBCMHFM_01582 3.7e-240 alaA 2.6.1.2, 2.6.1.66 E Aminotransferase
MDBCMHFM_01583 2.4e-75 XK27_03180 T universal stress protein
MDBCMHFM_01586 2e-157 pflA 1.97.1.4 C Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MDBCMHFM_01587 7.6e-239 hlyX S COG1253 Hemolysins and related proteins containing CBS domains
MDBCMHFM_01588 1.2e-143 modF 3.6.3.21, 3.6.3.34 P abc transporter atp-binding protein
MDBCMHFM_01589 0.0 yjcE P NhaP-type Na H and K H antiporters
MDBCMHFM_01591 1.4e-98 ytqB 2.1.1.176 J (SAM)-dependent
MDBCMHFM_01592 1.3e-184 yhcC S radical SAM protein
MDBCMHFM_01593 2.2e-196 ylbL T Belongs to the peptidase S16 family
MDBCMHFM_01594 2.7e-88 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MDBCMHFM_01595 2.5e-92 rsmD 2.1.1.171 L Methyltransferase
MDBCMHFM_01596 1.9e-172 trxB 1.8.1.9 C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
MDBCMHFM_01597 3.2e-09 S Protein of unknown function (DUF4059)
MDBCMHFM_01598 6.5e-131 tcyN 3.6.3.21 E abc transporter atp-binding protein
MDBCMHFM_01599 4.7e-163 yxeN P ABC transporter (Permease
MDBCMHFM_01600 1.5e-152 yxeM ET ABC-type amino acid transport signal transduction systems, periplasmic component domain
MDBCMHFM_01602 3.1e-206 dinB 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MDBCMHFM_01603 0.0 pflB 2.3.1.54 C formate acetyltransferase'
MDBCMHFM_01604 1.8e-147 cah 4.2.1.1 P carbonic anhydrase
MDBCMHFM_01605 2.1e-85 yjcF S COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
MDBCMHFM_01606 1e-44 hsdS_1 3.1.21.3 V type I restriction modification DNA specificity domain
MDBCMHFM_01607 2.9e-87 D nuclear chromosome segregation
MDBCMHFM_01608 1.5e-127 ybbM S transport system, permease component
MDBCMHFM_01609 3.6e-117 ybbL S abc transporter atp-binding protein
MDBCMHFM_01610 6.5e-184 ampC V COG1680 Beta-lactamase class C and other penicillin binding proteins
MDBCMHFM_01611 4.6e-140 cppA E CppA N-terminal
MDBCMHFM_01612 5e-44 V CAAX protease self-immunity
MDBCMHFM_01613 2.3e-164 gla U Belongs to the MIP aquaporin (TC 1.A.8) family
MDBCMHFM_01614 0.0 pepX 3.4.14.11 E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline
MDBCMHFM_01617 3e-47 spiA K sequence-specific DNA binding
MDBCMHFM_01618 2.9e-28 blpT
MDBCMHFM_01619 6.7e-98 blpT
MDBCMHFM_01620 5.1e-122 L Transposase
MDBCMHFM_01621 1.2e-165 L integrase core domain
MDBCMHFM_01626 4.3e-25 S Bacteriocin class II with double-glycine leader peptide
MDBCMHFM_01629 8.9e-133 agrA KT phosphorelay signal transduction system
MDBCMHFM_01630 2.5e-234 blpH 2.7.13.3 T protein histidine kinase activity
MDBCMHFM_01632 7.3e-237 mesE M Transport protein ComB
MDBCMHFM_01633 9.3e-281 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
MDBCMHFM_01634 2.8e-108 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
MDBCMHFM_01635 0.0 mdlB V abc transporter atp-binding protein
MDBCMHFM_01636 0.0 mdlA V abc transporter atp-binding protein
MDBCMHFM_01638 1.7e-93 XK27_09885 V Glycopeptide antibiotics resistance protein
MDBCMHFM_01639 7.9e-224 rlmN 2.1.1.192 J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
MDBCMHFM_01640 2.3e-72 yutD J protein conserved in bacteria
MDBCMHFM_01641 4.3e-269 yunD 3.1.3.5 F Belongs to the 5'-nucleotidase family
MDBCMHFM_01643 7.2e-221 cshB 3.6.4.13 JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
MDBCMHFM_01644 6.3e-185 mraY 2.7.8.13 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MDBCMHFM_01645 0.0 ftsI 3.4.16.4 M penicillin-binding protein
MDBCMHFM_01646 4.3e-47 ftsL D cell division protein FtsL
MDBCMHFM_01647 3e-157 rsmH 2.1.1.199 J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
MDBCMHFM_01648 1.6e-65
MDBCMHFM_01649 7.4e-27
MDBCMHFM_01650 2.6e-30
MDBCMHFM_01652 8.7e-33 yhaI J Protein of unknown function (DUF805)
MDBCMHFM_01653 4.5e-18 D nuclear chromosome segregation
MDBCMHFM_01654 2e-225 proA 1.2.1.41 E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MDBCMHFM_01655 1.7e-140 proB 2.7.2.11 E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MDBCMHFM_01656 2.2e-285 XK27_00765
MDBCMHFM_01657 8.1e-134 ecsA_2 V abc transporter atp-binding protein
MDBCMHFM_01658 5.2e-125 S Protein of unknown function (DUF554)
MDBCMHFM_01659 0.0 addA 3.6.4.12 L ATP-dependent helicase nuclease subunit A
MDBCMHFM_01660 0.0 rexB 3.1.21.3, 3.6.4.12 L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
MDBCMHFM_01661 2.6e-121 liaI S membrane
MDBCMHFM_01662 5.2e-75 XK27_02470 K LytTr DNA-binding domain
MDBCMHFM_01663 3.6e-66 KT response to antibiotic
MDBCMHFM_01664 5.2e-81 yebC M Membrane
MDBCMHFM_01665 2.9e-18 yebC M Membrane
MDBCMHFM_01666 4.3e-261 XK27_03190 5.2.1.8 S hydrolases of the HAD superfamily
MDBCMHFM_01667 6.2e-174 ansA 3.5.1.1 EJ COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D
MDBCMHFM_01669 0.0 recG 3.6.4.12 L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MDBCMHFM_01670 7.5e-184 alr 5.1.1.1, 5.1.1.5 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MDBCMHFM_01671 4.1e-62 acpS 2.7.6.3, 2.7.8.7, 5.1.1.1 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
MDBCMHFM_01672 1.1e-197 aroF 2.5.1.54 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MDBCMHFM_01673 3.8e-198 aroF 2.5.1.54 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MDBCMHFM_01674 0.0 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
MDBCMHFM_01676 3e-189 manA 5.3.1.8 G mannose-6-phosphate isomerase
MDBCMHFM_01677 1.2e-171 scrK 2.7.1.2, 2.7.1.4 GK Fructokinase
MDBCMHFM_01678 0.0 scrA 2.7.1.208, 2.7.1.211 G pts system
MDBCMHFM_01679 4.1e-291 scrB 3.2.1.26 GH32 G invertase
MDBCMHFM_01680 2.2e-179 scrR K Transcriptional
MDBCMHFM_01681 2.1e-73 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MDBCMHFM_01682 3.4e-62 yqhY S protein conserved in bacteria
MDBCMHFM_01683 1.2e-97 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MDBCMHFM_01684 3.7e-84 comEB 3.5.4.12 F ComE operon protein 2
MDBCMHFM_01685 5e-193 pepP 3.4.11.9, 3.4.13.9 E Belongs to the peptidase M24B family
MDBCMHFM_01687 8e-44 V 'abc transporter, ATP-binding protein
MDBCMHFM_01688 3.8e-58 V 'abc transporter, ATP-binding protein
MDBCMHFM_01691 0.0 uvrA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MDBCMHFM_01692 2e-169 corA P COG0598 Mg2 and Co2 transporters
MDBCMHFM_01693 3.1e-124 XK27_01040 S Pfam PF06570
MDBCMHFM_01695 9.7e-36 rpsR J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MDBCMHFM_01696 2.7e-91 ssb L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
MDBCMHFM_01697 3.9e-47 rpsF J Binds together with S18 to 16S ribosomal RNA
MDBCMHFM_01698 3.6e-41 XK27_05745
MDBCMHFM_01699 2.5e-230 mutY L A G-specific adenine glycosylase
MDBCMHFM_01704 0.0 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MDBCMHFM_01705 0.0 mutS2 L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
MDBCMHFM_01706 1e-93 cvpA S toxin biosynthetic process
MDBCMHFM_01707 2.3e-13 zapA D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
MDBCMHFM_01708 4.7e-160 rnhC 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MDBCMHFM_01709 1.3e-113 lepB 3.4.21.89 U Belongs to the peptidase S26 family
MDBCMHFM_01710 0.0 recD2 3.1.11.5 L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
MDBCMHFM_01711 2e-47 azlD E branched-chain amino acid
MDBCMHFM_01712 1.8e-114 azlC E AzlC protein
MDBCMHFM_01713 1.9e-186 tsaD 2.3.1.234 O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MDBCMHFM_01714 4.8e-73 rimI 2.3.1.128 K This enzyme acetylates the N-terminal alanine of ribosomal protein S18
MDBCMHFM_01715 5.6e-121 yeaZ 2.3.1.234 O COG1214, inactive homolog of metal-dependent proteases
MDBCMHFM_01716 2.5e-33 ykzG S Belongs to the UPF0356 family
MDBCMHFM_01717 0.0 rnjA S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MDBCMHFM_01718 2.7e-40 pscB M CHAP domain protein
MDBCMHFM_01719 1.5e-263 glnA 6.3.1.2 E glutamine synthetase
MDBCMHFM_01720 8.5e-63 glnR K Transcriptional regulator
MDBCMHFM_01721 1.3e-87 S Fusaric acid resistance protein-like
MDBCMHFM_01722 3e-13
MDBCMHFM_01723 8.9e-30
MDBCMHFM_01724 2e-222 pgk 2.7.2.3, 5.3.1.1 F Belongs to the phosphoglycerate kinase family
MDBCMHFM_01725 3.2e-42 L Transposase
MDBCMHFM_01726 1.9e-46 L transposase activity
MDBCMHFM_01727 2.5e-23 L Transposase
MDBCMHFM_01728 1.8e-56 L transposition
MDBCMHFM_01729 9.1e-83 L Integrase core domain protein
MDBCMHFM_01730 2e-103 L Transposase
MDBCMHFM_01731 1.3e-41 L Transposase
MDBCMHFM_01732 1.4e-189 gap 1.2.1.12 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
MDBCMHFM_01733 0.0 fusA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MDBCMHFM_01734 6.7e-81 rpsG J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
MDBCMHFM_01735 2.3e-69 rpsL J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MDBCMHFM_01736 1.1e-142 purR 2.4.2.7 F operon repressor
MDBCMHFM_01737 3.6e-179 cbf S 3'-5' exoribonuclease yhaM
MDBCMHFM_01738 6.9e-173 rmuC S RmuC domain protein
MDBCMHFM_01739 3.1e-118 thiN 2.7.6.2 H thiamine pyrophosphokinase
MDBCMHFM_01740 3e-119 rpe 5.1.3.1 G Belongs to the ribulose-phosphate 3-epimerase family
MDBCMHFM_01741 6.4e-162 rsgA 3.1.3.100 G One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
MDBCMHFM_01743 8.9e-156 ksgA 2.1.1.182 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
MDBCMHFM_01744 3.2e-98 rnmV 3.1.26.8 J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MDBCMHFM_01745 4.1e-144 tatD L Hydrolase, tatd
MDBCMHFM_01746 1.9e-74 yccU S CoA-binding protein
MDBCMHFM_01747 4.8e-51 trxA O Belongs to the thioredoxin family
MDBCMHFM_01748 1.9e-141 S Macro domain protein
MDBCMHFM_01749 2e-09 L thioesterase
MDBCMHFM_01750 1.3e-54 bta 1.8.1.8 CO cell redox homeostasis
MDBCMHFM_01753 8.6e-13
MDBCMHFM_01755 1.7e-226 tgt 2.4.2.29 F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
MDBCMHFM_01756 1e-33 L Transposase
MDBCMHFM_01757 1e-13 rpmH J Ribosomal protein L34
MDBCMHFM_01758 1.6e-249 L Transposase
MDBCMHFM_01759 2e-186 jag S RNA-binding protein
MDBCMHFM_01760 7.5e-141 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
MDBCMHFM_01761 7.6e-55 rnpA 3.1.26.5 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
MDBCMHFM_01762 1.9e-264 argH 4.3.2.1 E Argininosuccinate lyase
MDBCMHFM_01763 2e-230 argG 6.3.4.5 E Belongs to the argininosuccinate synthase family. Type 1 subfamily
MDBCMHFM_01764 6e-282 gltX 6.1.1.17, 6.1.1.24 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MDBCMHFM_01765 2.8e-79 amiA E transmembrane transport
MDBCMHFM_01766 4.2e-74 amiA E transmembrane transport
MDBCMHFM_01767 1.8e-119 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
MDBCMHFM_01768 3.7e-70 rplK J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MDBCMHFM_01769 9.2e-51 S Protein of unknown function (DUF3397)
MDBCMHFM_01770 6.6e-87 cah 4.2.1.1 P Reversible hydration of carbon dioxide
MDBCMHFM_01771 1.4e-36 WQ51_05710 S Mitochondrial biogenesis AIM24
MDBCMHFM_01772 1.8e-11 WQ51_05710 S Mitochondrial biogenesis AIM24
MDBCMHFM_01773 1.7e-221 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MDBCMHFM_01774 5.4e-80 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
MDBCMHFM_01775 4.7e-20 XK27_09620 S FMN reductase (NADPH) activity
MDBCMHFM_01776 4.3e-77 XK27_09620 S reductase
MDBCMHFM_01777 9e-62 XK27_09615 C reductase
MDBCMHFM_01778 2.3e-141 XK27_09615 C reductase
MDBCMHFM_01779 3.2e-62 fnt P Formate nitrite transporter
MDBCMHFM_01780 5.5e-64 XK27_08585 S Psort location CytoplasmicMembrane, score
MDBCMHFM_01781 2e-186 gpsA 1.1.1.94 I Glycerol-3-phosphate dehydrogenase
MDBCMHFM_01782 5.1e-170 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
MDBCMHFM_01783 5.2e-119 gluP 3.4.21.105 O membrane protein (homolog of Drosophila rhomboid)
MDBCMHFM_01784 9.1e-95 ygfA 6.3.3.2 H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MDBCMHFM_01785 7.9e-221 hipO 3.5.1.47 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
MDBCMHFM_01786 8.1e-59 dapD 2.3.1.117, 2.3.1.89 E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
MDBCMHFM_01787 2.7e-48 S glycolate biosynthetic process
MDBCMHFM_01788 1.3e-63 S phosphatase activity
MDBCMHFM_01789 7e-158 rrmA 2.1.1.187 Q methyltransferase
MDBCMHFM_01791 2.7e-91 tadA 3.5.4.1, 3.5.4.33 FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
MDBCMHFM_01792 5.1e-66 ssb_2 L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
MDBCMHFM_01793 6.4e-37 yeeD O sulfur carrier activity
MDBCMHFM_01794 1e-190 yeeE S Sulphur transport
MDBCMHFM_01795 7.9e-114 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
MDBCMHFM_01796 4.2e-55 ytpP 2.7.1.180, 5.3.4.1 CO Thioredoxin
MDBCMHFM_01797 4.1e-09 S Domain of unknown function (DUF4651)
MDBCMHFM_01798 2e-205 pepA 3.4.11.7 G COG1363 Cellulase M and related proteins
MDBCMHFM_01799 3.9e-131 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MDBCMHFM_01800 1.8e-111 S CAAX amino terminal protease family protein
MDBCMHFM_01802 5e-67 V CAAX protease self-immunity
MDBCMHFM_01803 1.4e-33 V CAAX protease self-immunity
MDBCMHFM_01805 2.9e-221 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MDBCMHFM_01806 5.9e-177 ytxK 2.1.1.72 L DNA methylase
MDBCMHFM_01807 2e-12 comGF U Putative Competence protein ComGF
MDBCMHFM_01808 1.5e-71 comGF U Competence protein ComGF
MDBCMHFM_01809 1.1e-15 NU Type II secretory pathway pseudopilin
MDBCMHFM_01810 1.8e-57 cglD NU Competence protein
MDBCMHFM_01811 8.5e-43 comGC U Required for transformation and DNA binding
MDBCMHFM_01812 3e-145 cglB NU type II secretion system
MDBCMHFM_01813 2.2e-176 comGA NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MDBCMHFM_01814 2.9e-68 S cog cog4699
MDBCMHFM_01815 0.0 rpoC 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MDBCMHFM_01816 0.0 rpoB 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MDBCMHFM_01817 0.0 pbp1B 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
MDBCMHFM_01818 9.3e-239 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MDBCMHFM_01819 1.6e-196 ilvC 1.1.1.86 H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MDBCMHFM_01820 7.7e-77 ilvN 2.2.1.6 E Acetolactate synthase
MDBCMHFM_01821 0.0 ilvB 2.2.1.6 EH Acetolactate synthase
MDBCMHFM_01822 1.5e-280 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
MDBCMHFM_01823 8.4e-09 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
MDBCMHFM_01824 9.9e-305 yloV S kinase related to dihydroxyacetone kinase
MDBCMHFM_01825 1.8e-57 asp S cog cog1302
MDBCMHFM_01826 3.2e-226 norN V Mate efflux family protein
MDBCMHFM_01827 1.9e-278 thrC 4.2.3.1 E Threonine synthase
MDBCMHFM_01828 3.2e-65 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
MDBCMHFM_01829 1.2e-35 adhE 1.1.1.1, 1.2.1.10 C hydroxyacid-oxoacid transhydrogenase activity
MDBCMHFM_01830 3.5e-76 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
MDBCMHFM_01831 1.3e-135 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
MDBCMHFM_01832 1.4e-63 adhE 1.1.1.1, 1.2.1.10 C Dehydrogenase
MDBCMHFM_01833 0.0 pepO 3.4.24.71 O Peptidase family M13
MDBCMHFM_01834 2.8e-38 treC 3.2.1.93 GH13 G COG0366 Glycosidases
MDBCMHFM_01835 1.2e-69 treC 3.2.1.93 GH13 G COG0366 Glycosidases
MDBCMHFM_01836 5.9e-66 treC 3.2.1.93 GH13 G COG0366 Glycosidases
MDBCMHFM_01837 1.4e-54 treB 2.7.1.201 G PTS System
MDBCMHFM_01838 5.8e-21 treR K DNA-binding transcription factor activity
MDBCMHFM_01839 1.2e-85 treR K trehalose operon
MDBCMHFM_01840 3.3e-95 ywlG S Belongs to the UPF0340 family
MDBCMHFM_01842 3.3e-09 L PFAM Integrase, catalytic core
MDBCMHFM_01843 4.2e-72 L PFAM Integrase, catalytic core
MDBCMHFM_01844 3.1e-87 L Phage integrase family
MDBCMHFM_01845 5.7e-46 S Domain of unknown function (DUF4298)
MDBCMHFM_01846 4.5e-61 cadC K helix_turn_helix, Arsenical Resistance Operon Repressor
MDBCMHFM_01847 0.0 cadA 3.6.3.3, 3.6.3.5 P COG2217 Cation transport ATPase
MDBCMHFM_01848 3.9e-141 3.1.21.3 V Type I restriction modification DNA specificity domain
MDBCMHFM_01849 2.4e-300 hsdM 2.1.1.72 V HsdM N-terminal domain
MDBCMHFM_01850 0.0 hsdR 3.1.21.3 V Subunit R is required for both nuclease and ATPase activities, but not for modification
MDBCMHFM_01851 8.2e-205 hsdR 3.1.21.3 L Subunit R is required for both nuclease and ATPase activities, but not for modification
MDBCMHFM_01852 2.4e-26
MDBCMHFM_01853 2e-222 L Transposase
MDBCMHFM_01854 1e-140 L DNA integration
MDBCMHFM_01855 9e-164 fba 4.1.2.13, 4.1.2.29 G aldolase
MDBCMHFM_01857 6.7e-110 6.3.2.2 H ergothioneine biosynthetic process
MDBCMHFM_01858 3.6e-64 6.3.2.2 H gamma-glutamylcysteine synthetase
MDBCMHFM_01859 7.2e-12 6.3.2.2 H gamma-glutamylcysteine synthetase
MDBCMHFM_01860 3.3e-09 L PFAM Integrase, catalytic core
MDBCMHFM_01861 4.2e-72 L PFAM Integrase, catalytic core
MDBCMHFM_01862 3.3e-62 rplQ J ribosomal protein l17
MDBCMHFM_01863 4.8e-171 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MDBCMHFM_01864 9.6e-62 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MDBCMHFM_01865 4e-57 rpsM J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MDBCMHFM_01866 6e-15 rpmJ J Belongs to the bacterial ribosomal protein bL36 family
MDBCMHFM_01867 2.7e-32 infA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MDBCMHFM_01868 9.2e-121 adk 2.7.4.3 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
MDBCMHFM_01869 9.6e-231 secY U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
MDBCMHFM_01870 4.4e-58 rplO J binds to the 23S rRNA
MDBCMHFM_01871 2.5e-23 rpmD J ribosomal protein l30
MDBCMHFM_01872 1.7e-79 rpsE J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MDBCMHFM_01873 1.9e-56 rplR J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MDBCMHFM_01874 2.3e-93 rplF J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MDBCMHFM_01875 1.2e-67 rpsH J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MDBCMHFM_01876 1.5e-28 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MDBCMHFM_01877 1.6e-94 rplE J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MDBCMHFM_01878 1.4e-47 rplX J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MDBCMHFM_01879 1.1e-59 rplN J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MDBCMHFM_01880 6e-39 rpsQ J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MDBCMHFM_01881 2.7e-26 rpmC J Belongs to the universal ribosomal protein uL29 family
MDBCMHFM_01882 7.2e-71 rplP J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MDBCMHFM_01883 2.1e-117 rpsC J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MDBCMHFM_01884 7.3e-53 rplV J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MDBCMHFM_01885 4.9e-47 rpsS J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MDBCMHFM_01886 8.8e-153 rplB J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MDBCMHFM_01887 2.4e-44 rplW J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
MDBCMHFM_01888 5.7e-104 rplD J Forms part of the polypeptide exit tunnel
MDBCMHFM_01889 1.1e-110 rplC J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MDBCMHFM_01890 1.3e-48 rpsJ J Involved in the binding of tRNA to the ribosomes
MDBCMHFM_01891 7.8e-188 ruvB 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
MDBCMHFM_01892 0.0 XK27_09800 I Acyltransferase
MDBCMHFM_01893 1.7e-35 XK27_09805 S MORN repeat protein
MDBCMHFM_01894 1e-80 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MDBCMHFM_01895 4.1e-250 purA 6.3.4.4 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MDBCMHFM_01896 8.8e-83 adk 2.7.4.3 F topology modulation protein
MDBCMHFM_01897 3.1e-172 yxaM EGP Major facilitator Superfamily
MDBCMHFM_01898 1.9e-197 2.7.7.73, 2.7.7.80 H Involved in molybdopterin and thiamine biosynthesis, family 2
MDBCMHFM_01899 4.8e-54 L Transposase
MDBCMHFM_01900 7.5e-149 L Transposase
MDBCMHFM_01902 3.4e-155 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
MDBCMHFM_01903 0.0 KLT serine threonine protein kinase
MDBCMHFM_01904 2.1e-280 V ABC transporter
MDBCMHFM_01905 2.7e-12 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
MDBCMHFM_01906 1.4e-127 Z012_04635 K sequence-specific DNA binding
MDBCMHFM_01908 6.3e-16 C Radical SAM
MDBCMHFM_01909 3.4e-191 C Radical SAM
MDBCMHFM_01910 3.9e-287 V ABC transporter transmembrane region
MDBCMHFM_01911 1.3e-60 K sequence-specific DNA binding
MDBCMHFM_01912 3.1e-14 K Cro/C1-type HTH DNA-binding domain
MDBCMHFM_01913 1.3e-36 L Replication initiation factor
MDBCMHFM_01914 1.4e-107 L Replication initiation factor
MDBCMHFM_01915 1.9e-18 S Domain of unknown function (DUF3173)
MDBCMHFM_01916 3.5e-216 int L Belongs to the 'phage' integrase family
MDBCMHFM_01918 5.2e-237 rarA L ATPase related to the helicase subunit of the Holliday junction resolvase
MDBCMHFM_01919 8.4e-27 rpmB J Belongs to the bacterial ribosomal protein bL28 family
MDBCMHFM_01920 2.8e-44 yrzL S Belongs to the UPF0297 family
MDBCMHFM_01921 1.2e-70 yqgF L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MDBCMHFM_01922 4.2e-44 yrzB S Belongs to the UPF0473 family
MDBCMHFM_01923 2.3e-301 ccs S the current gene model (or a revised gene model) may contain a frame shift
MDBCMHFM_01924 0.0 nrdD 1.1.98.6 F Ribonucleoside-triphosphate reductase
MDBCMHFM_01925 7.5e-14
MDBCMHFM_01926 2.6e-91 XK27_10930 K acetyltransferase
MDBCMHFM_01927 1.1e-115 nrdG 1.97.1.4 O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MDBCMHFM_01928 1.8e-147 yaaA S Belongs to the UPF0246 family
MDBCMHFM_01929 9.9e-169 XK27_01785 S cog cog1284
MDBCMHFM_01930 0.0 aspS 6.1.1.12 J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
MDBCMHFM_01932 1.6e-241 hisS 6.1.1.21 J histidyl-tRNA synthetase
MDBCMHFM_01933 5.7e-52 metE 2.1.1.14 E Methionine synthase
MDBCMHFM_01934 7.6e-64 metE 2.1.1.14 E Methionine synthase
MDBCMHFM_01935 9.2e-36 metE 2.1.1.14 E Methionine synthase
MDBCMHFM_01936 2e-25 rpmF J Belongs to the bacterial ribosomal protein bL32 family
MDBCMHFM_01937 6.7e-19 rpmG J Belongs to the bacterial ribosomal protein bL33 family
MDBCMHFM_01939 3.1e-20 yegS 2.7.1.107 I lipid kinase activity
MDBCMHFM_01940 2.7e-95 S Hydrophobic domain protein
MDBCMHFM_01942 3.7e-27 S Membrane
MDBCMHFM_01943 3.1e-101
MDBCMHFM_01944 1.8e-23 S Small integral membrane protein
MDBCMHFM_01945 4.3e-71 M Protein conserved in bacteria
MDBCMHFM_01946 4.9e-12 K CsbD-like
MDBCMHFM_01947 7.2e-95 nudL L hydrolase
MDBCMHFM_01948 3.4e-13 nudL L hydrolase
MDBCMHFM_01949 4.3e-222 L Transposase
MDBCMHFM_01950 4e-19 K negative regulation of transcription, DNA-templated
MDBCMHFM_01951 1.7e-23 K negative regulation of transcription, DNA-templated
MDBCMHFM_01953 3.1e-19 XK27_06920 S Protein of unknown function (DUF1700)
MDBCMHFM_01954 1.8e-88 S Putative adhesin
MDBCMHFM_01955 3.9e-161 XK27_06930 V domain protein
MDBCMHFM_01956 6.4e-96 XK27_06935 K transcriptional regulator
MDBCMHFM_01957 4.8e-55 ypaA M Membrane
MDBCMHFM_01958 2.7e-08
MDBCMHFM_01959 9.8e-109 rpsD J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MDBCMHFM_01960 8.2e-48 veg S Biofilm formation stimulator VEG
MDBCMHFM_01961 1.5e-245 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
MDBCMHFM_01962 3.9e-70 rplI J binds to the 23S rRNA
MDBCMHFM_01963 0.0 yybT T signaling protein consisting of a modified GGDEF domain and a DHH domain
MDBCMHFM_01964 0.0 gidA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
MDBCMHFM_01965 1.5e-77 F NUDIX domain
MDBCMHFM_01966 3.3e-219 mnmA 2.8.1.13 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
MDBCMHFM_01967 0.0 S Bacterial membrane protein, YfhO
MDBCMHFM_01968 1.5e-91 isaA GH23 M Immunodominant staphylococcal antigen A
MDBCMHFM_01969 3.1e-93 lytE M LysM domain protein
MDBCMHFM_01970 2.2e-137 ecfT P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MDBCMHFM_01971 5.2e-153 ecfA2 3.6.3.55 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MDBCMHFM_01972 1.5e-152 ecfA1 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MDBCMHFM_01973 6.9e-90 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MDBCMHFM_01974 3.7e-138 ymfM S sequence-specific DNA binding
MDBCMHFM_01975 1.4e-242 ymfH S Peptidase M16
MDBCMHFM_01976 1.4e-234 ymfF S Peptidase M16
MDBCMHFM_01977 1.2e-43 yaaA S S4 domain protein YaaA
MDBCMHFM_01978 1.7e-204 recF L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MDBCMHFM_01979 1.5e-275 guaB 1.1.1.205 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
MDBCMHFM_01980 8.2e-193 trpS 6.1.1.2 J Tryptophanyl-tRNA synthetase
MDBCMHFM_01981 1.1e-153 yvjA S membrane
MDBCMHFM_01982 6.7e-306 ybiT S abc transporter atp-binding protein
MDBCMHFM_01983 0.0 XK27_10405 S Bacterial membrane protein YfhO
MDBCMHFM_01987 6.2e-120 yoaK S Psort location CytoplasmicMembrane, score
MDBCMHFM_01988 1.1e-86 rlmH 2.1.1.177 J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MDBCMHFM_01989 5.3e-194 htrA 3.4.21.107 O Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain'
MDBCMHFM_01990 1e-134 parB K Belongs to the ParB family

eggNOG-mapper v2 (Database: eggNOG v5.0, Jul. 2018 release)