ORF_ID e_value Gene_name EC_number CAZy COGs Description
MNLHAPDI_00001 3.9e-37 ykuJ S protein conserved in bacteria
MNLHAPDI_00002 4.4e-94 ykuK S Ribonuclease H-like
MNLHAPDI_00003 3.9e-27 ykzF S Antirepressor AbbA
MNLHAPDI_00004 1.6e-76 ykuL S CBS domain
MNLHAPDI_00005 3.5e-168 ccpC K Transcriptional regulator
MNLHAPDI_00006 8.5e-84 fld C Flavodoxin domain
MNLHAPDI_00007 3e-175 ykuO
MNLHAPDI_00008 3.9e-78 fld C Flavodoxin
MNLHAPDI_00009 1.1e-74 dapD 2.3.1.117, 2.3.1.89 E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
MNLHAPDI_00010 2.4e-214 hipO 3.5.1.47 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
MNLHAPDI_00011 9e-37 ykuS S Belongs to the UPF0180 family
MNLHAPDI_00012 8.8e-142 ykuT M Mechanosensitive ion channel
MNLHAPDI_00013 3.9e-101 ykuU O Alkyl hydroperoxide reductase
MNLHAPDI_00014 6.3e-81 ykuV CO thiol-disulfide
MNLHAPDI_00015 5.8e-95 rok K Repressor of ComK
MNLHAPDI_00016 3.2e-146 yknT
MNLHAPDI_00017 1.1e-109 mobA 2.7.7.77 H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
MNLHAPDI_00018 6.5e-190 moeB 2.7.7.73, 2.7.7.80 H COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
MNLHAPDI_00019 2.4e-245 moeA 2.10.1.1 H molybdopterin
MNLHAPDI_00020 9.9e-94 mobB 2.10.1.1, 2.7.7.77 H molybdopterin-guanine dinucleotide biosynthesis protein
MNLHAPDI_00021 2.7e-82 moaE 2.8.1.12 H COG0314 Molybdopterin converting factor, large subunit
MNLHAPDI_00022 8.3e-32 moaD 2.8.1.12 H Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MNLHAPDI_00023 0.0 yknU V COG1132 ABC-type multidrug transport system, ATPase and permease components
MNLHAPDI_00024 0.0 yknV V COG1132 ABC-type multidrug transport system, ATPase and permease components
MNLHAPDI_00025 2.9e-117 yknW S Yip1 domain
MNLHAPDI_00026 4.3e-158 acrA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MNLHAPDI_00027 2.5e-124 macB V ABC transporter, ATP-binding protein
MNLHAPDI_00028 5.6e-209 yknZ V COG0577 ABC-type antimicrobial peptide transport system, permease component
MNLHAPDI_00029 3.1e-136 fruR K Transcriptional regulator
MNLHAPDI_00030 1.8e-167 fruK 2.7.1.11, 2.7.1.56 G Belongs to the carbohydrate kinase PfkB family
MNLHAPDI_00031 0.0 fruA 2.7.1.202 GT COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type)
MNLHAPDI_00032 4.8e-105 sipT 3.4.21.89 U Belongs to the peptidase S26 family
MNLHAPDI_00033 8.1e-39 ykoA
MNLHAPDI_00034 5.8e-310 ybiT S COG0488 ATPase components of ABC transporters with duplicated ATPase domains
MNLHAPDI_00035 1.5e-169 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MNLHAPDI_00036 2e-238 ampS E COG2309 Leucyl aminopeptidase (aminopeptidase T)
MNLHAPDI_00037 1.1e-12 S Uncharacterized protein YkpC
MNLHAPDI_00038 7.7e-183 mreB D Rod-share determining protein MreBH
MNLHAPDI_00039 1.5e-43 abrB K of stationary sporulation gene expression
MNLHAPDI_00040 2.7e-241 kinC 2.7.13.3 T COG0642 Signal transduction histidine kinase
MNLHAPDI_00041 1.6e-162 ykqA P Gamma-glutamyl cyclotransferase, AIG2-like
MNLHAPDI_00042 4e-116 ktrA P COG0569 K transport systems, NAD-binding component
MNLHAPDI_00043 0.0 ade 3.5.4.2 F Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MNLHAPDI_00044 0.0 rnjA S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MNLHAPDI_00045 8.2e-31 ykzG S Belongs to the UPF0356 family
MNLHAPDI_00046 1.4e-147 ykrA S hydrolases of the HAD superfamily
MNLHAPDI_00047 4e-101 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
MNLHAPDI_00049 2e-115 recN L Putative cell-wall binding lipoprotein
MNLHAPDI_00050 9.9e-192 pdhA 1.2.4.1, 1.2.4.4 C COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
MNLHAPDI_00051 2.9e-179 pdhB 1.2.4.1, 1.2.4.4 C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
MNLHAPDI_00052 9.9e-231 pdhC 2.3.1.12 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
MNLHAPDI_00053 2.4e-243 lpdA 1.8.1.4 C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
MNLHAPDI_00054 1.3e-63 slp CO COG0526, thiol-disulfide isomerase and thioredoxins
MNLHAPDI_00055 3.5e-277 speA 4.1.1.19 E Arginine
MNLHAPDI_00056 1.6e-42 yktA S Belongs to the UPF0223 family
MNLHAPDI_00057 7.1e-118 yktB S Belongs to the UPF0637 family
MNLHAPDI_00058 7.1e-26 ykzI
MNLHAPDI_00059 4.6e-151 suhB 3.1.3.25 G Inositol monophosphatase
MNLHAPDI_00060 6.9e-78 ykzC S Acetyltransferase (GNAT) family
MNLHAPDI_00061 6.5e-173 Q Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MNLHAPDI_00062 2.2e-293 mpl 3.4.24.28, 3.4.24.29 E Peptidase M4
MNLHAPDI_00063 0.0 ylaA
MNLHAPDI_00064 2.7e-42 ylaB
MNLHAPDI_00065 1.3e-90 ylaC K Belongs to the sigma-70 factor family. ECF subfamily
MNLHAPDI_00066 1.2e-11 sigC S Putative zinc-finger
MNLHAPDI_00067 1.8e-38 ylaE
MNLHAPDI_00068 8.2e-22 S Family of unknown function (DUF5325)
MNLHAPDI_00069 0.0 typA T GTP-binding protein TypA
MNLHAPDI_00070 4.2e-47 ylaH S YlaH-like protein
MNLHAPDI_00071 2.5e-32 ylaI S protein conserved in bacteria
MNLHAPDI_00072 1.1e-89 ylaJ S Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
MNLHAPDI_00073 8e-249 phoH T ATPase related to phosphate starvation-inducible protein PhoH
MNLHAPDI_00074 2.7e-85 ylaL S Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MNLHAPDI_00075 1.6e-171 glsA 3.5.1.2 E Belongs to the glutaminase family
MNLHAPDI_00076 8.7e-44 ylaN S Belongs to the UPF0358 family
MNLHAPDI_00077 4.5e-214 ftsW D Belongs to the SEDS family
MNLHAPDI_00078 0.0 pyc 6.4.1.1 C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MNLHAPDI_00079 2.6e-166 ctaA 2.5.1.141 O Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group
MNLHAPDI_00080 3.2e-164 ctaB 2.5.1.141 O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
MNLHAPDI_00081 6.2e-191 ctaC 1.9.3.1 C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)
MNLHAPDI_00082 0.0 ctaD 1.10.3.12, 1.9.3.1 C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MNLHAPDI_00083 3.3e-112 cyoC 1.10.3.12, 1.9.3.1 C COG1845 Heme copper-type cytochrome quinol oxidase, subunit 3
MNLHAPDI_00084 4.2e-53 ctaF 1.10.3.12, 1.9.3.1 C COG3125 Heme copper-type cytochrome quinol oxidase, subunit 4
MNLHAPDI_00085 3e-167 ctaG S cytochrome c oxidase
MNLHAPDI_00086 7e-62 ylbA S YugN-like family
MNLHAPDI_00087 2.6e-74 ylbB T COG0517 FOG CBS domain
MNLHAPDI_00088 3e-201 ylbC S protein with SCP PR1 domains
MNLHAPDI_00089 4.1e-63 ylbD S Putative coat protein
MNLHAPDI_00090 6.7e-37 ylbE S YlbE-like protein
MNLHAPDI_00091 1.8e-75 ylbF S Belongs to the UPF0342 family
MNLHAPDI_00092 3.7e-38 ylbG S UPF0298 protein
MNLHAPDI_00093 1.6e-97 rsmD 2.1.1.171 L Methyltransferase
MNLHAPDI_00094 3.9e-84 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MNLHAPDI_00095 1.1e-220 ylbJ S Sporulation integral membrane protein YlbJ
MNLHAPDI_00096 7.5e-138 ylbK S esterase of the alpha-beta hydrolase superfamily
MNLHAPDI_00097 6.8e-187 ylbL T Belongs to the peptidase S16 family
MNLHAPDI_00098 2.8e-235 ylbM S Belongs to the UPF0348 family
MNLHAPDI_00100 2.3e-90 yceD S metal-binding, possibly nucleic acid-binding protein
MNLHAPDI_00101 1.2e-27 rpmF J Belongs to the bacterial ribosomal protein bL32 family
MNLHAPDI_00102 6.8e-75 ylbO S SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
MNLHAPDI_00103 4e-89 ylbP K n-acetyltransferase
MNLHAPDI_00104 1e-167 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MNLHAPDI_00105 7.4e-305 bshC S Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
MNLHAPDI_00106 2.9e-78 mraZ K Belongs to the MraZ family
MNLHAPDI_00107 6.6e-173 rsmH 2.1.1.199 J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
MNLHAPDI_00108 3.7e-44 ftsL D Essential cell division protein
MNLHAPDI_00109 0.0 ftsI 3.4.16.4 M Penicillin-binding Protein
MNLHAPDI_00110 0.0 ftsI 3.4.16.4 M stage V sporulation protein D
MNLHAPDI_00111 5.2e-281 murE 6.3.2.10, 6.3.2.13 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MNLHAPDI_00112 3.2e-170 mraY 2.7.8.13 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MNLHAPDI_00113 2.6e-255 murD 6.3.2.9 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MNLHAPDI_00114 5.7e-186 spoVE D Belongs to the SEDS family
MNLHAPDI_00115 1.6e-199 murG 2.4.1.227, 6.3.2.8 GT28 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MNLHAPDI_00116 5.3e-167 murB 1.3.1.98 M cell wall formation
MNLHAPDI_00117 1.7e-137 divIB D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
MNLHAPDI_00118 2.4e-103 ylxW S protein conserved in bacteria
MNLHAPDI_00119 5.1e-102 ylxX S protein conserved in bacteria
MNLHAPDI_00120 6.2e-58 sbp S small basic protein
MNLHAPDI_00121 7e-229 ftsA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
MNLHAPDI_00122 2e-203 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MNLHAPDI_00123 0.0 bpr O COG1404 Subtilisin-like serine proteases
MNLHAPDI_00124 4.4e-172 spoIIGA M aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR
MNLHAPDI_00125 1.4e-125 sigE K sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MNLHAPDI_00126 3.6e-140 sigG K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MNLHAPDI_00127 1.1e-147 modF 3.6.3.21, 3.6.3.34 P COG1119 ABC-type molybdenum transport system, ATPase component photorepair protein PhrA
MNLHAPDI_00128 2.9e-256 argE 3.5.1.16 E Acetylornithine deacetylase
MNLHAPDI_00129 2.4e-37 ylmC S sporulation protein
MNLHAPDI_00130 1.1e-158 yfiH S Belongs to the multicopper oxidase YfiH RL5 family
MNLHAPDI_00131 2.9e-125 ylmE S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MNLHAPDI_00132 1.4e-62 sepF D Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
MNLHAPDI_00133 1.3e-39 yggT S membrane
MNLHAPDI_00134 6.7e-139 ylmH 5.4.99.23, 5.4.99.24 S conserved protein, contains S4-like domain
MNLHAPDI_00135 2.6e-67 divIVA D Cell division initiation protein
MNLHAPDI_00136 0.0 ileS 6.1.1.5 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MNLHAPDI_00137 1.3e-63 dksA T COG1734 DnaK suppressor protein
MNLHAPDI_00138 1.8e-78 lspA 3.4.23.36 MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MNLHAPDI_00139 5.5e-164 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
MNLHAPDI_00140 2.7e-94 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MNLHAPDI_00141 6.4e-230 pyrP F Xanthine uracil
MNLHAPDI_00142 1.5e-166 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
MNLHAPDI_00143 4.1e-250 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
MNLHAPDI_00144 5e-212 carA 6.3.5.5 F Carbamoyl-phosphate synthetase glutamine chain
MNLHAPDI_00145 0.0 carB 6.3.5.5 F Belongs to the CarB family
MNLHAPDI_00146 4.8e-145 pyrK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )
MNLHAPDI_00147 2.9e-176 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
MNLHAPDI_00148 8e-126 pyrF 4.1.1.23 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
MNLHAPDI_00149 2.9e-116 pyrE 2.4.2.10, 4.1.1.23 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MNLHAPDI_00151 3.5e-142 cysH 1.8.4.10, 1.8.4.8, 2.7.1.25 EH Belongs to the PAPS reductase family. CysH subfamily
MNLHAPDI_00152 1.1e-179 cysP P phosphate transporter
MNLHAPDI_00153 1.3e-223 sat 2.7.7.4 P Belongs to the sulfate adenylyltransferase family
MNLHAPDI_00154 7.3e-109 cysC 2.7.1.25 P Catalyzes the synthesis of activated sulfate
MNLHAPDI_00155 2.2e-145 hemD 2.1.1.107, 4.2.1.75 H Belongs to the precorrin methyltransferase family
MNLHAPDI_00156 2e-146 cbiX 4.99.1.3, 4.99.1.4, 5.4.99.60, 5.4.99.61 S Sirohydrochlorin ferrochelatase
MNLHAPDI_00157 4.3e-83 cysG 1.3.1.76, 4.99.1.4 H Siroheme synthase
MNLHAPDI_00158 0.0 FbpA K RNA-binding protein homologous to eukaryotic snRNP
MNLHAPDI_00159 0.0 yloB 3.6.3.8 P COG0474 Cation transport ATPase
MNLHAPDI_00160 2.4e-156 yloC S stress-induced protein
MNLHAPDI_00161 1.5e-40 ylzA S Belongs to the UPF0296 family
MNLHAPDI_00162 3.1e-110 gmk 2.7.4.8 F Essential for recycling GMP and indirectly, cGMP
MNLHAPDI_00163 2.2e-28 rpoZ 2.7.7.6 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
MNLHAPDI_00164 3.3e-225 coaBC 4.1.1.36, 6.3.2.5 H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MNLHAPDI_00165 0.0 priA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MNLHAPDI_00166 6e-85 def 2.1.2.9, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
MNLHAPDI_00167 3.8e-176 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MNLHAPDI_00168 2.9e-254 sun 2.1.1.176 J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MNLHAPDI_00169 4.8e-207 rlmN 2.1.1.192 J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
MNLHAPDI_00170 2.4e-141 stp 3.1.3.16 T phosphatase
MNLHAPDI_00171 0.0 prkC 2.7.11.1 KLT serine threonine protein kinase
MNLHAPDI_00172 8.6e-170 rsgA 3.1.3.100 S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
MNLHAPDI_00173 4.2e-118 rpe 5.1.3.1 G Belongs to the ribulose-phosphate 3-epimerase family
MNLHAPDI_00174 3.1e-121 thiN 2.7.6.2 H thiamine pyrophosphokinase
MNLHAPDI_00175 4.2e-26 rpmB J Belongs to the bacterial ribosomal protein bL28 family
MNLHAPDI_00176 5.5e-59 asp S protein conserved in bacteria
MNLHAPDI_00177 2.1e-299 yloV S kinase related to dihydroxyacetone kinase
MNLHAPDI_00178 1.9e-118 sdaAB 4.3.1.17 E L-serine dehydratase
MNLHAPDI_00179 9.3e-156 sdaAA 4.3.1.17 E L-serine dehydratase
MNLHAPDI_00180 0.0 recG 3.6.4.12 L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MNLHAPDI_00181 4e-80 fapR 5.3.1.23 K Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism
MNLHAPDI_00182 4.3e-178 plsX 2.3.1.15 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
MNLHAPDI_00183 2.7e-169 fabD 2.3.1.39 I malonyl CoA-acyl carrier protein transacylase
MNLHAPDI_00184 1.1e-127 IQ reductase
MNLHAPDI_00185 2.8e-32 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
MNLHAPDI_00186 1.2e-135 rnc 3.1.26.3 J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
MNLHAPDI_00187 0.0 smc D Required for chromosome condensation and partitioning
MNLHAPDI_00188 8.8e-176 ftsY U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
MNLHAPDI_00189 3.5e-85
MNLHAPDI_00190 1.6e-49 ylxM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
MNLHAPDI_00191 1e-235 ffh 3.6.5.4 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MNLHAPDI_00192 1.1e-43 rpsP J Belongs to the bacterial ribosomal protein bS16 family
MNLHAPDI_00193 4.5e-36 ylqC S Belongs to the UPF0109 family
MNLHAPDI_00194 6.3e-61 ylqD S YlqD protein
MNLHAPDI_00195 5.3e-95 rimM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MNLHAPDI_00196 7.8e-137 trmD 2.1.1.228, 4.6.1.12 J Belongs to the RNA methyltransferase TrmD family
MNLHAPDI_00197 1.4e-56 rplS J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
MNLHAPDI_00198 2.3e-156 ylqF S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MNLHAPDI_00199 9e-136 rnhB 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MNLHAPDI_00200 4.3e-287 ylqG
MNLHAPDI_00201 3e-44 ylqH S homolog of the cytoplasmic domain of flagellar protein FhlB
MNLHAPDI_00202 3.4e-211 sucC 6.2.1.5 C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
MNLHAPDI_00203 1.1e-167 sucD 6.2.1.5 C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MNLHAPDI_00204 1.7e-170 dprA LU Rossmann fold nucleotide-binding protein involved in DNA uptake
MNLHAPDI_00205 0.0 topA 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MNLHAPDI_00206 7.4e-247 trmFO 2.1.1.74 J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
MNLHAPDI_00207 2.5e-169 xerC L tyrosine recombinase XerC
MNLHAPDI_00208 4.4e-92 hslV 3.4.25.2 O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MNLHAPDI_00209 1.5e-250 hslU O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MNLHAPDI_00210 9.2e-136 codY K DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
MNLHAPDI_00211 2.3e-63 flgB N Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body
MNLHAPDI_00212 6.9e-75 flgC N Belongs to the flagella basal body rod proteins family
MNLHAPDI_00213 1.9e-31 fliE N Flagellar hook-basal body
MNLHAPDI_00214 2.4e-255 fliF N The M ring may be actively involved in energy transduction
MNLHAPDI_00215 2e-178 fliG N One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation
MNLHAPDI_00216 2.5e-106 fliH NU COG1317 Flagellar biosynthesis type III secretory pathway protein
MNLHAPDI_00217 2.5e-242 fliI 3.6.3.14 NU COG1157 Flagellar biosynthesis type III secretory pathway ATPase
MNLHAPDI_00218 1.5e-69 fliJ N Flagellar biosynthesis chaperone
MNLHAPDI_00219 7.7e-37 ylxF S MgtE intracellular N domain
MNLHAPDI_00220 1.2e-221 fliK N Flagellar hook-length control protein
MNLHAPDI_00221 1.7e-72 flgD N Flagellar basal body rod modification protein
MNLHAPDI_00222 8.2e-140 flgG N Flagellar basal body rod
MNLHAPDI_00223 4.6e-49 fliL N Controls the rotational direction of flagella during chemotaxis
MNLHAPDI_00224 1.9e-181 fliM N One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation
MNLHAPDI_00225 4.5e-184 fliN N FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MNLHAPDI_00226 6.1e-58 cheB 3.1.1.61, 3.5.1.44 T response regulator
MNLHAPDI_00227 2.7e-96 fliZ N Flagellar biosynthesis protein, FliO
MNLHAPDI_00228 1.6e-109 fliP N Plays a role in the flagellum-specific transport system
MNLHAPDI_00229 2.2e-36 fliQ N Role in flagellar biosynthesis
MNLHAPDI_00230 3.6e-132 fliR N Flagellar biosynthetic protein FliR
MNLHAPDI_00231 1.4e-190 flhB N Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MNLHAPDI_00232 0.0 flhA N Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MNLHAPDI_00233 5.2e-201 flhF N Flagellar biosynthesis regulator FlhF
MNLHAPDI_00234 4.1e-156 flhG D Belongs to the ParA family
MNLHAPDI_00235 5.8e-197 cheB 3.1.1.61, 3.5.1.44 NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR
MNLHAPDI_00236 0.0 cheA 2.7.13.3 NT COG0643 Chemotaxis protein histidine kinase and related kinases
MNLHAPDI_00237 2.8e-79 cheW NT COG0835 Chemotaxis signal transduction protein
MNLHAPDI_00238 1.3e-111 cheC NT COG1776 Chemotaxis protein CheC, inhibitor of MCP methylation
MNLHAPDI_00239 1.1e-86 cheD 3.5.1.44 NT Deamidates glutamine residues to glutamate on methyl- accepting chemotaxis receptors (MCPs). CheD-mediated MCP deamidation is required for productive communication of the conformational signals of the chemoreceptors to the CheA kinase
MNLHAPDI_00240 9.6e-138 sigD K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MNLHAPDI_00241 1.3e-77 ylxL
MNLHAPDI_00242 1e-131 rpsB J Belongs to the universal ribosomal protein uS2 family
MNLHAPDI_00243 6.3e-157 tsf J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MNLHAPDI_00244 2.7e-126 pyrH 2.7.4.22 F Catalyzes the reversible phosphorylation of UMP to UDP
MNLHAPDI_00245 6.4e-91 frr J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
MNLHAPDI_00246 8.3e-145 uppS 2.5.1.31 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MNLHAPDI_00247 1.2e-138 cdsA 2.7.7.41 S Belongs to the CDS family
MNLHAPDI_00248 4.6e-216 dxr 1.1.1.267 I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
MNLHAPDI_00249 7.7e-233 rasP M zinc metalloprotease
MNLHAPDI_00250 0.0 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
MNLHAPDI_00251 0.0 polC 2.7.7.7 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MNLHAPDI_00252 3.3e-80 rimP S Required for maturation of 30S ribosomal subunits
MNLHAPDI_00253 1.1e-203 nusA K Participates in both transcription termination and antitermination
MNLHAPDI_00254 7.5e-32 ylxR K nucleic-acid-binding protein implicated in transcription termination
MNLHAPDI_00255 3.1e-47 ylxQ J ribosomal protein
MNLHAPDI_00256 0.0 infB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MNLHAPDI_00257 3.9e-44 ylxP S protein conserved in bacteria
MNLHAPDI_00258 5e-57 rbfA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MNLHAPDI_00259 1.5e-172 truB 5.4.99.25 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MNLHAPDI_00260 3e-181 ribF 2.7.1.26, 2.7.7.2 H Belongs to the ribF family
MNLHAPDI_00261 6e-42 rpsO J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MNLHAPDI_00262 0.0 pnp 2.7.7.8 J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
MNLHAPDI_00263 1.2e-180 ylxY 3.5.1.104 G Sporulation protein, polysaccharide deacetylase
MNLHAPDI_00264 4.4e-233 pepR S Belongs to the peptidase M16 family
MNLHAPDI_00265 2.6e-42 ymxH S YlmC YmxH family
MNLHAPDI_00266 2.9e-162 spoVFA 1.1.1.29, 1.1.1.399, 1.1.1.95 CH Dipicolinate synthase subunit A
MNLHAPDI_00267 2.2e-108 spoVFB H Together with DpaA, catalyzes the conversion of dihydrodipicolinate to dipicolinate (DPA)
MNLHAPDI_00268 3.2e-192 asd 1.2.1.11 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MNLHAPDI_00269 1.7e-221 dapG 1.1.1.3, 2.7.2.4 E Belongs to the aspartokinase family
MNLHAPDI_00270 4e-156 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MNLHAPDI_00271 1.9e-308 rnjB S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MNLHAPDI_00272 5.3e-133 tepA 3.4.21.92 OU COG0740 Protease subunit of ATP-dependent Clp proteases
MNLHAPDI_00273 4.4e-32 S YlzJ-like protein
MNLHAPDI_00274 0.0 ftsK D Belongs to the FtsK SpoIIIE SftA family
MNLHAPDI_00275 1.4e-133 ymfC K Transcriptional regulator
MNLHAPDI_00276 3.8e-205 ymfD EGP Major facilitator Superfamily
MNLHAPDI_00277 2e-233 ymfF S Peptidase M16
MNLHAPDI_00278 4.1e-242 ymfH S zinc protease
MNLHAPDI_00279 7.8e-129 ymfI 1.1.1.100, 1.3.1.28 S Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
MNLHAPDI_00280 4.8e-41 ymfJ S Protein of unknown function (DUF3243)
MNLHAPDI_00281 2.7e-143 ymfK S Protein of unknown function (DUF3388)
MNLHAPDI_00282 1.9e-124 ymfM S protein conserved in bacteria
MNLHAPDI_00283 2.5e-101 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MNLHAPDI_00284 9.6e-236 cinA 3.5.1.42 S Belongs to the CinA family
MNLHAPDI_00285 8.1e-188 recA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MNLHAPDI_00286 2.6e-214 pbpX V Beta-lactamase
MNLHAPDI_00287 2.1e-224 rny S Endoribonuclease that initiates mRNA decay
MNLHAPDI_00288 7.1e-152 ymdB S protein conserved in bacteria
MNLHAPDI_00289 1.2e-36 spoVS S Stage V sporulation protein S
MNLHAPDI_00290 3e-198 tdh 1.1.1.103 C Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate
MNLHAPDI_00291 7.2e-217 kbl 2.3.1.29, 2.3.1.47 H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide
MNLHAPDI_00292 8.5e-295 miaB 2.8.4.3 J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MNLHAPDI_00293 9.2e-69 ymcA 3.6.3.21 S Belongs to the UPF0342 family
MNLHAPDI_00294 2.2e-88 cotE S Spore coat protein
MNLHAPDI_00295 0.0 mutS L that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MNLHAPDI_00296 0.0 mutL L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MNLHAPDI_00297 5.1e-70 S Regulatory protein YrvL
MNLHAPDI_00299 7.9e-97 ymcC S Membrane
MNLHAPDI_00300 4.4e-109 pksA K Transcriptional regulator
MNLHAPDI_00301 2.5e-129 pksB 3.1.2.6 S Polyketide biosynthesis
MNLHAPDI_00302 2.6e-163 fabD 2.3.1.39 I malonyl CoA-acyl carrier protein transacylase
MNLHAPDI_00303 2.4e-186 pksD Q Acyl transferase domain
MNLHAPDI_00304 0.0 fabD 1.13.12.16, 2.3.1.39 I malonyl CoA-acyl carrier protein transacylase
MNLHAPDI_00305 1.4e-37 acpK IQ Phosphopantetheine attachment site
MNLHAPDI_00306 2.7e-238 pksF 2.3.1.179, 2.3.1.41 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
MNLHAPDI_00307 1.3e-245 pksG 2.3.3.10 I synthase
MNLHAPDI_00308 2.6e-143 pksH 4.2.1.18 I enoyl-CoA hydratase
MNLHAPDI_00309 2.7e-137 pksI I Belongs to the enoyl-CoA hydratase isomerase family
MNLHAPDI_00310 0.0 rhiB IQ polyketide synthase
MNLHAPDI_00311 0.0 pfaA Q Polyketide synthase of type I
MNLHAPDI_00312 0.0 pfaA 4.1.1.35 GT4 IQ polyketide synthase
MNLHAPDI_00313 0.0 dhbF IQ polyketide synthase
MNLHAPDI_00314 0.0 pks13 HQ Beta-ketoacyl synthase
MNLHAPDI_00315 1.4e-231 cypA C Cytochrome P450
MNLHAPDI_00316 4.4e-61 ymzB
MNLHAPDI_00317 8.9e-161 ymaE S Metallo-beta-lactamase superfamily
MNLHAPDI_00318 1.5e-250 aprX O Belongs to the peptidase S8 family
MNLHAPDI_00319 1.9e-07 K Transcriptional regulator
MNLHAPDI_00320 2.1e-126 ymaC S Replication protein
MNLHAPDI_00321 1.6e-79 ymaD O redox protein, regulator of disulfide bond formation
MNLHAPDI_00322 1.4e-54 ebrB P COG2076 Membrane transporters of cations and cationic drugs
MNLHAPDI_00323 5.4e-50 ebrA P Small Multidrug Resistance protein
MNLHAPDI_00325 2.1e-46 ymaF S YmaF family
MNLHAPDI_00326 9.3e-175 miaA 2.5.1.75 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MNLHAPDI_00327 1.9e-33 hfq J RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs
MNLHAPDI_00328 8.2e-23
MNLHAPDI_00329 4.5e-22 ymzA
MNLHAPDI_00330 1.9e-49 nrdI 1.17.4.1 F Probably involved in ribonucleotide reductase function
MNLHAPDI_00331 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MNLHAPDI_00332 4.5e-188 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MNLHAPDI_00333 2e-109 ymaB
MNLHAPDI_00334 8e-116 cwlC 3.5.1.28 M n-acetylmuramoyl-L-alanine amidase
MNLHAPDI_00335 1.7e-176 spoVK O stage V sporulation protein K
MNLHAPDI_00336 5.5e-231 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MNLHAPDI_00337 3.3e-244 ynbB 4.4.1.1 P COG4100 Cystathionine beta-lyase family protein involved in aluminum resistance
MNLHAPDI_00338 1.1e-68 glnR K transcriptional
MNLHAPDI_00339 7e-261 glnA 6.3.1.2 E glutamine synthetase
MNLHAPDI_00340 5e-10
MNLHAPDI_00341 2.5e-32
MNLHAPDI_00342 5.8e-39
MNLHAPDI_00343 6.8e-80 G regulation of fungal-type cell wall biogenesis
MNLHAPDI_00344 4.9e-145 ynaC
MNLHAPDI_00345 2e-99 ynaD J Acetyltransferase (GNAT) domain
MNLHAPDI_00346 1.9e-123 ynaE S Domain of unknown function (DUF3885)
MNLHAPDI_00347 6.4e-60 ynaF
MNLHAPDI_00350 1.1e-83 XK27_05370 5.3.1.24 E phosphoribosylanthranilate isomerase activity
MNLHAPDI_00351 2.7e-255 xynT G MFS/sugar transport protein
MNLHAPDI_00352 0.0 xynB 3.2.1.37 GH43 G Belongs to the glycosyl hydrolase 43 family
MNLHAPDI_00353 1e-215 xylR GK ROK family
MNLHAPDI_00354 4e-264 xylA 5.3.1.5 G Belongs to the xylose isomerase family
MNLHAPDI_00355 3.3e-291 xylB 2.7.1.12, 2.7.1.17, 2.7.1.5 G xylulose kinase
MNLHAPDI_00356 4.9e-111 yokF 3.1.31.1 L RNA catabolic process
MNLHAPDI_00357 7.5e-253 iolT EGP Major facilitator Superfamily
MNLHAPDI_00358 1.1e-217 alr 5.1.1.1 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MNLHAPDI_00359 5e-81 yncE S Protein of unknown function (DUF2691)
MNLHAPDI_00360 5.3e-77 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F Deoxyuridine 5'-triphosphate
MNLHAPDI_00361 5.2e-15
MNLHAPDI_00364 1.2e-165 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MNLHAPDI_00366 1.3e-134 S Domain of unknown function, YrpD
MNLHAPDI_00369 7.9e-25 tatA U protein secretion
MNLHAPDI_00370 1.8e-71
MNLHAPDI_00371 5.2e-80 yndB S Activator of Hsp90 ATPase homolog 1-like protein
MNLHAPDI_00374 5.7e-286 gerAA EG Spore germination protein
MNLHAPDI_00375 4.5e-197 gerAB U Spore germination
MNLHAPDI_00376 4.2e-220 gerLC S Spore germination protein
MNLHAPDI_00377 7.7e-154 yndG S DoxX-like family
MNLHAPDI_00378 2.6e-117 yndH S Domain of unknown function (DUF4166)
MNLHAPDI_00379 0.0 yndJ S YndJ-like protein
MNLHAPDI_00381 8.6e-139 yndL S Replication protein
MNLHAPDI_00382 5.8e-74 yndM S Protein of unknown function (DUF2512)
MNLHAPDI_00383 2e-79 fosB 2.5.1.18 H Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor
MNLHAPDI_00385 2.6e-109 lexA 3.4.21.88 K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MNLHAPDI_00386 3.4e-49 yneA D Inhibits cell division during the SOS response. Affects a later stage of the cell division protein assembly, after the assembly of the Z ring, by probably suppressing recruitment of FtsL and or DivIC to the division machinery
MNLHAPDI_00387 9.2e-113 yneB L resolvase
MNLHAPDI_00388 1.3e-32 ynzC S UPF0291 protein
MNLHAPDI_00389 0.0 tkt 2.2.1.1 G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MNLHAPDI_00390 2.2e-81 yneE S Sporulation inhibitor of replication protein sirA
MNLHAPDI_00391 1.8e-28 yneF S UPF0154 protein
MNLHAPDI_00392 7.5e-14 ynzD S Spo0E like sporulation regulatory protein
MNLHAPDI_00393 7.1e-127 ccdA O cytochrome c biogenesis protein
MNLHAPDI_00394 7.2e-59 cheB 3.1.1.61, 3.5.1.44 T cheY-homologous receiver domain
MNLHAPDI_00395 5.1e-76 yneJ O COG4846 Membrane protein involved in cytochrome C biogenesis
MNLHAPDI_00396 4.2e-74 yneK S Protein of unknown function (DUF2621)
MNLHAPDI_00397 4.1e-65 hspX O Spore coat protein
MNLHAPDI_00398 3.9e-19 sspP S Belongs to the SspP family
MNLHAPDI_00399 2.2e-14 sspO S Belongs to the SspO family
MNLHAPDI_00400 0.0 acnA 4.2.1.3 C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MNLHAPDI_00401 4.1e-92 yneN CO alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MNLHAPDI_00403 3.1e-08 sspN S Small acid-soluble spore protein N family
MNLHAPDI_00404 3.9e-35 tlp S Belongs to the Tlp family
MNLHAPDI_00405 1.2e-73 yneP S Thioesterase-like superfamily
MNLHAPDI_00406 1.3e-53 yneQ
MNLHAPDI_00407 4.1e-49 yneR S Belongs to the HesB IscA family
MNLHAPDI_00408 5e-94 plsY 2.3.1.15, 3.5.1.104 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
MNLHAPDI_00409 6.6e-69 yccU S CoA-binding protein
MNLHAPDI_00410 0.0 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
MNLHAPDI_00411 0.0 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
MNLHAPDI_00412 2.3e-12
MNLHAPDI_00413 1.3e-57 ynfC
MNLHAPDI_00414 8.2e-252 agcS E Sodium alanine symporter
MNLHAPDI_00415 2.4e-297 bglC5 3.2.1.4 GH5,GH9 G PFAM glycoside hydrolase family 5
MNLHAPDI_00417 3.7e-251 xynC 3.2.1.136 GH5 M Belongs to the glycosyl hydrolase 30 family
MNLHAPDI_00418 4.4e-299 xynD3 3.2.1.55 CBM6,GH43 G Belongs to the glycosyl hydrolase 43 family
MNLHAPDI_00419 2.4e-80 yngA S membrane
MNLHAPDI_00420 4.1e-164 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
MNLHAPDI_00421 5.5e-104 yngC S membrane-associated protein
MNLHAPDI_00422 1.9e-233 nrnB S phosphohydrolase (DHH superfamily)
MNLHAPDI_00423 6.3e-290 yngE 2.1.3.15, 6.4.1.3 I COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
MNLHAPDI_00424 2.2e-137 yngF 4.2.1.17 I Belongs to the enoyl-CoA hydratase isomerase family
MNLHAPDI_00425 8e-168 mvaB 4.1.3.4, 6.4.1.4 E Hydroxymethylglutaryl-CoA lyase
MNLHAPDI_00426 6e-32 pycB 2.3.1.12, 6.4.1.1 I Biotin carboxyl carrier protein
MNLHAPDI_00427 3e-251 yngH 6.3.4.14, 6.4.1.2, 6.4.1.3, 6.4.1.4 I Biotin carboxylase
MNLHAPDI_00428 0.0 yngI IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
MNLHAPDI_00429 4.4e-211 yngJ 1.3.8.1, 1.3.99.12 I acyl-CoA dehydrogenase
MNLHAPDI_00430 1.8e-31 S Family of unknown function (DUF5367)
MNLHAPDI_00432 6.3e-306 yngK T Glycosyl hydrolase-like 10
MNLHAPDI_00433 2.8e-64 yngL S Protein of unknown function (DUF1360)
MNLHAPDI_00434 0.0 6.3.2.14 Q amino acid activation for nonribosomal peptide biosynthetic process
MNLHAPDI_00435 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MNLHAPDI_00436 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MNLHAPDI_00437 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MNLHAPDI_00438 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MNLHAPDI_00439 4.3e-275 dacC 3.4.16.4 M D-alanyl-D-alanine carboxypeptidase
MNLHAPDI_00440 9e-189 yoxA 5.1.3.3 G Aldose 1-epimerase
MNLHAPDI_00441 2.3e-246 yoeA V MATE efflux family protein
MNLHAPDI_00442 1.1e-98 yoeB S IseA DL-endopeptidase inhibitor
MNLHAPDI_00444 2.2e-96 L Integrase
MNLHAPDI_00445 3e-34 yoeD G Helix-turn-helix domain
MNLHAPDI_00446 0.0 ggt 2.3.2.2, 3.4.19.13 E gamma-glutamyltransferase
MNLHAPDI_00447 1.5e-155 gltR1 K Transcriptional regulator
MNLHAPDI_00448 9.4e-186 yogA C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases
MNLHAPDI_00449 2.5e-291 gltD 1.4.1.13, 1.4.1.14 E COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases
MNLHAPDI_00450 0.0 gltB 1.4.1.13, 1.4.1.14, 1.4.7.1 E glutamate synthase
MNLHAPDI_00451 7.8e-155 gltC K Transcriptional regulator
MNLHAPDI_00452 2.5e-203 proB 2.7.2.11 E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MNLHAPDI_00453 5.6e-144 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MNLHAPDI_00454 1.9e-59 rtp K Plays a role in DNA replication and termination (fork arrest mechanism). Two dimers of rtp bind to the two inverted repeat regions (IRI and IRII) present in the termination site. The binding of each dimer is centered on an 8 bp direct repeat
MNLHAPDI_00455 2.2e-123 fabG 1.1.1.100 S Belongs to the short-chain dehydrogenases reductases (SDR) family
MNLHAPDI_00456 9.8e-41 yoxC S Bacterial protein of unknown function (DUF948)
MNLHAPDI_00457 1.1e-141 yoxB
MNLHAPDI_00458 1.3e-93 yoaA 2.3.1.128 J COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
MNLHAPDI_00459 2.6e-127 V ABC-2 family transporter protein
MNLHAPDI_00460 1.3e-94 V ABC-2 family transporter protein
MNLHAPDI_00461 2.8e-139 V AAA domain, putative AbiEii toxin, Type IV TA system
MNLHAPDI_00462 3e-80 hpr K helix_turn_helix multiple antibiotic resistance protein
MNLHAPDI_00463 9.9e-233 yoaB EGP Major facilitator Superfamily
MNLHAPDI_00464 7.4e-280 yoaC 2.7.1.12, 2.7.1.17, 2.7.1.189, 2.7.1.5 G FGGY family of carbohydrate kinases, C-terminal domain
MNLHAPDI_00465 6.2e-185 yoaD 1.1.1.399, 1.1.1.95 EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MNLHAPDI_00466 0.0 yoaE C belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MNLHAPDI_00467 1.9e-33 yoaF
MNLHAPDI_00468 2.2e-08 ywlA S Uncharacterised protein family (UPF0715)
MNLHAPDI_00469 7e-14
MNLHAPDI_00470 1.5e-38 S Protein of unknown function (DUF4025)
MNLHAPDI_00471 1.7e-187 mcpU NT methyl-accepting chemotaxis protein
MNLHAPDI_00472 8.7e-281 hpaB 1.14.14.9 Q COG2368 Aromatic ring hydroxylase
MNLHAPDI_00473 3.8e-133 yoaJ G Endoglucanase C-terminal domain subunit and related proteins
MNLHAPDI_00474 2.3e-111 yoaK S Membrane
MNLHAPDI_00475 2.5e-197 pelB 4.2.2.10, 4.2.2.2 G Amb_all
MNLHAPDI_00476 1.1e-132 yoqW S Belongs to the SOS response-associated peptidase family
MNLHAPDI_00478 3.8e-234 oxdC 4.1.1.2 G Oxalate decarboxylase
MNLHAPDI_00480 1.9e-146 yoaP 3.1.3.18 K YoaP-like
MNLHAPDI_00481 1.2e-66 yoaQ S Evidence 4 Homologs of previously reported genes of
MNLHAPDI_00482 4.1e-89
MNLHAPDI_00483 2.4e-172 yoaR V vancomycin resistance protein
MNLHAPDI_00484 4.3e-75 yoaS S Protein of unknown function (DUF2975)
MNLHAPDI_00485 4.2e-37 yozG K Transcriptional regulator
MNLHAPDI_00486 1.4e-147 yoaT S Protein of unknown function (DUF817)
MNLHAPDI_00487 4.3e-158 yoaU K LysR substrate binding domain
MNLHAPDI_00488 1.5e-158 yijE EG EamA-like transporter family
MNLHAPDI_00489 1.8e-77 yoaW
MNLHAPDI_00490 1.3e-116 yoaZ 1.11.1.6, 3.5.1.124 S DJ-1/PfpI family
MNLHAPDI_00491 5.9e-166 bla 3.5.2.6 V beta-lactamase
MNLHAPDI_00495 0.0 pps 2.7.9.2 GT phosphoenolpyruvate synthase
MNLHAPDI_00496 1.8e-121 xlnB 3.2.1.8 G Glycosyl hydrolases family 11
MNLHAPDI_00497 1.4e-37 S TM2 domain
MNLHAPDI_00498 5.7e-58 K Helix-turn-helix
MNLHAPDI_00500 1.6e-69 yoaQ S Evidence 4 Homologs of previously reported genes of
MNLHAPDI_00501 6.6e-127 yoqW S Belongs to the SOS response-associated peptidase family
MNLHAPDI_00502 1.8e-178 yobF
MNLHAPDI_00507 1.7e-207 S aspartate phosphatase
MNLHAPDI_00509 1.2e-123 dinB2 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MNLHAPDI_00510 1.4e-59 dinB2 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MNLHAPDI_00511 2.6e-38 S YolD-like protein
MNLHAPDI_00512 1.2e-49
MNLHAPDI_00513 0.0 K Psort location Cytoplasmic, score
MNLHAPDI_00514 2.7e-157 yobJ
MNLHAPDI_00515 3e-86 S SMI1-KNR4 cell-wall
MNLHAPDI_00516 0.0 L A nuclease of the HNH/ENDO VII superfamily with conserved LHH
MNLHAPDI_00517 7.9e-105 yokH G SMI1 / KNR4 family
MNLHAPDI_00518 9.5e-280 iaaM 1.4.3.4 E COG1231 Monoamine oxidase
MNLHAPDI_00519 0.0 yobO M Pectate lyase superfamily protein
MNLHAPDI_00520 9.9e-55 csaA 6.1.1.10, 6.1.1.20, 6.1.1.6 J tRNA-binding protein
MNLHAPDI_00521 1e-136 yobQ K helix_turn_helix, arabinose operon control protein
MNLHAPDI_00522 2.5e-143 yobR 2.3.1.1 J FR47-like protein
MNLHAPDI_00523 3e-99 yobS K Transcriptional regulator
MNLHAPDI_00524 4.2e-132 yobT S COG0491 Zn-dependent hydrolases, including glyoxylases
MNLHAPDI_00525 1.5e-88 yobU K Bacterial transcription activator, effector binding domain
MNLHAPDI_00526 9e-178 yobV K WYL domain
MNLHAPDI_00527 3.2e-95 yobW
MNLHAPDI_00528 1e-51 czrA K transcriptional
MNLHAPDI_00529 4.4e-118 pvaA M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)
MNLHAPDI_00530 1.5e-92 yozB S membrane
MNLHAPDI_00531 2.2e-145
MNLHAPDI_00532 1.9e-94 yocC
MNLHAPDI_00533 6.9e-189 yocD 3.4.17.13 V peptidase S66
MNLHAPDI_00534 4.1e-203 des 1.14.19.23, 1.14.19.45 I fatty acid desaturase
MNLHAPDI_00535 3.2e-198 desK 2.7.13.3 T Histidine kinase
MNLHAPDI_00536 1e-105 desR T COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MNLHAPDI_00537 7.1e-113 yocH CBM50 M COG1388 FOG LysM repeat
MNLHAPDI_00538 0.0 recQ 3.6.4.12 L DNA helicase
MNLHAPDI_00539 7.9e-114 azoR I Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MNLHAPDI_00540 3.3e-83 dksA T general stress protein
MNLHAPDI_00541 6.4e-54 yocL
MNLHAPDI_00542 6.6e-34
MNLHAPDI_00543 1.3e-87 yocM O Belongs to the small heat shock protein (HSP20) family
MNLHAPDI_00544 1.1e-40 yozN
MNLHAPDI_00545 1.9e-36 yocN
MNLHAPDI_00546 4.2e-56 yozO S Bacterial PH domain
MNLHAPDI_00547 2.7e-31 yozC
MNLHAPDI_00548 4e-289 dhaS 1.2.1.3, 1.2.1.39 C Belongs to the aldehyde dehydrogenase family
MNLHAPDI_00549 0.0 sqhC 4.2.1.137, 5.4.99.7 I COG1657 Squalene cyclase
MNLHAPDI_00550 1.3e-164 sodA 1.15.1.1 P Superoxide dismutase
MNLHAPDI_00551 9.9e-231 yocR S Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
MNLHAPDI_00552 8.6e-168 yocS S -transporter
MNLHAPDI_00553 3.5e-193 sucB 2.3.1.61 C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)
MNLHAPDI_00554 0.0 sucA 1.2.4.2, 4.1.1.71 C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)
MNLHAPDI_00555 0.0 yojO P Von Willebrand factor
MNLHAPDI_00556 1.1e-161 yojN S ATPase family associated with various cellular activities (AAA)
MNLHAPDI_00557 1.5e-109 sodC 1.15.1.1 P Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MNLHAPDI_00558 4.6e-198 sle1 3.5.1.28 CBM50 M COG1388 FOG LysM repeat
MNLHAPDI_00559 4.1e-231 yojK CG UDP-glucoronosyl and UDP-glucosyl transferase
MNLHAPDI_00560 1.2e-109 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MNLHAPDI_00562 4.2e-245 norM V Multidrug efflux pump
MNLHAPDI_00563 8.4e-151 T COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
MNLHAPDI_00564 2.1e-125 yojG S deacetylase
MNLHAPDI_00565 2.2e-60 yojF S Protein of unknown function (DUF1806)
MNLHAPDI_00566 1.5e-43
MNLHAPDI_00567 6.6e-162 rarD S -transporter
MNLHAPDI_00568 2.6e-61 yozR S COG0071 Molecular chaperone (small heat shock protein)
MNLHAPDI_00569 3.4e-09
MNLHAPDI_00570 8.2e-209 gntP EG COG2610 H gluconate symporter and related permeases
MNLHAPDI_00571 3.8e-66 yodA S tautomerase
MNLHAPDI_00572 1.7e-57 yodB K transcriptional
MNLHAPDI_00573 4.8e-108 yodC C nitroreductase
MNLHAPDI_00574 3.8e-113 mhqD S Carboxylesterase
MNLHAPDI_00575 5.8e-174 yodE E COG0346 Lactoylglutathione lyase and related lyases
MNLHAPDI_00576 6.2e-28 S Protein of unknown function (DUF3311)
MNLHAPDI_00577 4.2e-270 yodF E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MNLHAPDI_00578 1.9e-253 ctpA 3.4.21.102 M Belongs to the peptidase S41A family
MNLHAPDI_00579 1.7e-128 yodH Q Methyltransferase
MNLHAPDI_00580 5.2e-24 yodI
MNLHAPDI_00581 2.5e-139 vanY 3.4.17.14 M D-alanyl-D-alanine carboxypeptidase
MNLHAPDI_00582 3.2e-127 deoD 2.4.2.1, 2.4.2.28 F Purine nucleoside phosphorylase
MNLHAPDI_00583 5.3e-09
MNLHAPDI_00584 3.6e-54 yodL S YodL-like
MNLHAPDI_00585 5.4e-107 yodM 3.6.1.27 I Acid phosphatase homologues
MNLHAPDI_00586 2.8e-24 yozD S YozD-like protein
MNLHAPDI_00588 1.4e-124 yodN
MNLHAPDI_00589 1.4e-36 yozE S Belongs to the UPF0346 family
MNLHAPDI_00590 2.9e-47 yokU S YokU-like protein, putative antitoxin
MNLHAPDI_00591 1.4e-278 kamA 5.4.3.2 E lysine 2,3-aminomutase
MNLHAPDI_00592 2.5e-155 yodP 2.3.1.264 K Acetyltransferase (GNAT) family
MNLHAPDI_00593 1.4e-258 yodQ 3.5.1.16 E Acetylornithine deacetylase
MNLHAPDI_00594 1.6e-117 scoB 2.8.3.5, 2.8.3.8, 2.8.3.9 I COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit
MNLHAPDI_00595 8.1e-10 yodS 2.8.3.8, 2.8.3.9 I COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MNLHAPDI_00596 1.6e-249 yodT H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MNLHAPDI_00598 2.9e-145 yiiD K acetyltransferase
MNLHAPDI_00599 1e-256 cgeD M maturation of the outermost layer of the spore
MNLHAPDI_00600 3.5e-38 cgeC
MNLHAPDI_00601 1.2e-65 cgeA
MNLHAPDI_00602 3.3e-188 cgeB S Spore maturation protein
MNLHAPDI_00603 3.6e-213 phy 3.1.3.8 I Myo-inositol-hexaphosphate 3-phosphohydrolase
MNLHAPDI_00604 5.6e-125 4.2.1.115 GM Polysaccharide biosynthesis protein
MNLHAPDI_00605 1.4e-80 msrB 1.8.4.11, 1.8.4.12 O peptide methionine sulfoxide reductase
MNLHAPDI_00606 7e-103 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MNLHAPDI_00607 1.6e-70 ypoP K transcriptional
MNLHAPDI_00608 2.6e-223 mepA V MATE efflux family protein
MNLHAPDI_00609 5.5e-29 ypmT S Uncharacterized ympT
MNLHAPDI_00610 1.1e-98 ypmS S protein conserved in bacteria
MNLHAPDI_00611 1.3e-137 ypmR E GDSL-like Lipase/Acylhydrolase
MNLHAPDI_00612 3.5e-108 ypmQ S protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems
MNLHAPDI_00613 3.1e-40 ypmP S Protein of unknown function (DUF2535)
MNLHAPDI_00614 4.4e-244 ilvA 4.3.1.19 E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MNLHAPDI_00615 1.6e-185 pspF K Transcriptional regulator
MNLHAPDI_00616 4.2e-110 hlyIII S protein, Hemolysin III
MNLHAPDI_00617 3.7e-111 ypkP 2.3.1.51 I Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family
MNLHAPDI_00618 5.1e-95 folA 1.1.1.262, 1.5.1.3 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MNLHAPDI_00619 2.1e-156 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MNLHAPDI_00620 3.3e-92 pgpA 3.1.3.27 I COG1267 Phosphatidylglycerophosphatase A and related proteins
MNLHAPDI_00621 7.8e-114 ypjP S YpjP-like protein
MNLHAPDI_00622 1.6e-143 ypiP 2.1.1.242 AJ Putative SAM-dependent methyltransferase
MNLHAPDI_00623 1.7e-75 yphP S Belongs to the UPF0403 family
MNLHAPDI_00624 0.0 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
MNLHAPDI_00625 1.8e-156 ypgR C COG0694 Thioredoxin-like proteins and domains
MNLHAPDI_00626 3.1e-110 ypgQ S phosphohydrolase
MNLHAPDI_00627 2.3e-89 btuE 1.11.1.9 O Belongs to the glutathione peroxidase family
MNLHAPDI_00628 4.7e-176 metAA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MNLHAPDI_00629 2e-216 ugtP 2.4.1.315 GT28 M Processive glucosyltransferase involved in the biosynthesis of both the bilayer- and non-bilayer-forming membrane glucolipids. Is able to successively transfer up to three glucosyl residues to diacylglycerol (DAG), thereby catalyzing the formation of beta-monoglucosyl-DAG (3-O-(beta-D-glucopyranosyl)-1,2-diacyl- sn-glycerol), beta-diglucosyl-DAG (3-O-(beta-D-glucopyranosyl- beta-(1- 6)-D-glucopyranosyl)-1,2-diacyl-sn-glycerol) and beta- triglucosyl-DAG (3-O-(beta-D-glucopyranosyl-beta-(1- 6)-D- glucopyranosyl-beta-(1- 6)-D-glucopyranosyl)-1,2-diacyl-sn- glycerol). Beta-diglucosyl-DAG is the predominant glycolipid found in Bacillales and is also used as a membrane anchor for lipoteichoic acid (LTA)
MNLHAPDI_00630 7.9e-31 cspD K Cold-shock protein
MNLHAPDI_00631 3.8e-16 degR
MNLHAPDI_00632 8.1e-31 S Protein of unknown function (DUF2564)
MNLHAPDI_00633 2.6e-27 ypeQ S Zinc-finger
MNLHAPDI_00634 8.9e-127 ypeP 3.1.26.4 L COG0328 Ribonuclease HI
MNLHAPDI_00635 5.4e-107 ypdP S Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MNLHAPDI_00636 8.5e-69 rnhA 3.1.26.4 L Ribonuclease
MNLHAPDI_00638 1.5e-166 polA 2.7.7.7 L 5'3' exonuclease
MNLHAPDI_00639 2e-07
MNLHAPDI_00640 1e-38 ypbS S Protein of unknown function (DUF2533)
MNLHAPDI_00641 0.0 ypbR S Dynamin family
MNLHAPDI_00642 5.1e-87 ypbQ S protein conserved in bacteria
MNLHAPDI_00643 4.4e-208 bcsA Q Naringenin-chalcone synthase
MNLHAPDI_00644 1.6e-228 pbuX F xanthine
MNLHAPDI_00645 8.8e-99 xpt 2.4.2.22, 2.4.2.7 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
MNLHAPDI_00646 9.3e-294 ypwA 3.4.17.19 E Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
MNLHAPDI_00647 5e-171 kdgT P The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system
MNLHAPDI_00648 7e-104 eda 2.7.1.45, 4.1.2.14, 4.1.3.42 G 2-dehydro-3-deoxy-phosphogluconate aldolase
MNLHAPDI_00649 2.9e-187 kdgK 2.7.1.45 G COG0524 Sugar kinases, ribokinase family
MNLHAPDI_00650 3.9e-187 ptxS K transcriptional
MNLHAPDI_00651 1.7e-159 kduI 5.3.1.17 G Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
MNLHAPDI_00652 7.1e-133 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MNLHAPDI_00653 0.0 ypvA 3.6.4.12 KL COG1199 Rad3-related DNA helicases
MNLHAPDI_00655 5.4e-225 rlmL 2.1.1.173, 2.1.1.264 L Belongs to the methyltransferase superfamily
MNLHAPDI_00656 2.8e-45 gpsB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
MNLHAPDI_00657 3.3e-92 ypsA S Belongs to the UPF0398 family
MNLHAPDI_00658 1.3e-237 yprB L RNase_H superfamily
MNLHAPDI_00659 0.0 yprA L COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster
MNLHAPDI_00660 1.9e-81 ypqE 2.7.1.199 G COG2190 Phosphotransferase system IIA components
MNLHAPDI_00661 8.6e-72 hspX O Belongs to the small heat shock protein (HSP20) family
MNLHAPDI_00662 1.2e-48 yppG S YppG-like protein
MNLHAPDI_00664 2e-11 yppE S Bacterial domain of unknown function (DUF1798)
MNLHAPDI_00667 2.6e-188 yppC S Protein of unknown function (DUF2515)
MNLHAPDI_00668 1.2e-114 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
MNLHAPDI_00669 0.0 ponA 2.4.1.129, 2.7.7.7, 3.4.16.4 GT51 M penicillin-binding protein
MNLHAPDI_00670 4.7e-93 ypoC
MNLHAPDI_00671 2.2e-122 nth 4.2.99.18 L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MNLHAPDI_00672 5.7e-129 dnaD L DNA replication protein DnaD
MNLHAPDI_00673 5.8e-252 asnS 6.1.1.22 J asparaginyl-tRNA
MNLHAPDI_00674 1.5e-222 aspB 2.6.1.1, 2.6.1.14 E Aminotransferase
MNLHAPDI_00675 3.4e-80 ypmB S protein conserved in bacteria
MNLHAPDI_00676 6.7e-23 ypmA S Protein of unknown function (DUF4264)
MNLHAPDI_00677 0.0 dinG 2.7.7.7, 3.6.4.12 L helicase involved in DNA repair and perhaps also replication
MNLHAPDI_00678 3.5e-64 panD 4.1.1.11 H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MNLHAPDI_00679 1.6e-157 panC 2.7.4.25, 6.3.2.1 H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MNLHAPDI_00680 1.4e-150 panB 2.1.2.11 H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
MNLHAPDI_00681 8.7e-184 birA 6.3.4.15 K Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
MNLHAPDI_00682 5e-218 cca 2.7.7.19, 2.7.7.72 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
MNLHAPDI_00683 6.9e-209 bshA GT4 M N-acetyl-alpha-D-glucosaminyl L-malate synthase
MNLHAPDI_00684 1.7e-128 bshB1 S proteins, LmbE homologs
MNLHAPDI_00685 6.5e-72 mgsA 2.7.1.24, 4.2.3.3 G methylglyoxal synthase
MNLHAPDI_00686 1.8e-147 dapB 1.17.1.8 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
MNLHAPDI_00687 2.6e-55 ypjD 2.5.1.19 S Nucleotide pyrophosphohydrolase
MNLHAPDI_00688 8.1e-157 ypjC S Uncharacterized protein conserved in bacteria (DUF2179)
MNLHAPDI_00689 6.1e-143 ypjB S sporulation protein
MNLHAPDI_00690 2e-98 ypjA S membrane
MNLHAPDI_00691 1.5e-146 qcrC C Menaquinol-cytochrome c reductase cytochrome b c subunit
MNLHAPDI_00692 5.2e-127 petB C COG1290 Cytochrome b subunit of the bc complex
MNLHAPDI_00693 9.3e-97 qcrA C Menaquinol-cytochrome c reductase
MNLHAPDI_00694 8.5e-78 ypiF S Protein of unknown function (DUF2487)
MNLHAPDI_00695 2.8e-99 ypiB S Belongs to the UPF0302 family
MNLHAPDI_00696 4.1e-234 S COG0457 FOG TPR repeat
MNLHAPDI_00697 8.9e-237 aroA 1.3.1.12, 1.3.1.43, 2.5.1.19 E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
MNLHAPDI_00698 1.2e-208 tyrA 1.3.1.12, 1.3.1.43 E prephenate dehydrogenase
MNLHAPDI_00699 2.9e-204 hisC 2.6.1.9 E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MNLHAPDI_00700 5.5e-144 trpA 4.2.1.20 E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
MNLHAPDI_00701 4e-231 trpB 4.2.1.20, 5.3.1.24 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
MNLHAPDI_00702 6.5e-119 trpF 4.1.1.48, 4.2.1.160, 4.2.1.20, 5.3.1.24 E Belongs to the TrpF family
MNLHAPDI_00703 4.7e-113 trpC 4.1.1.48, 5.3.1.24 E Belongs to the TrpC family
MNLHAPDI_00704 1.2e-180 trpD 2.4.2.18, 4.1.3.27 E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MNLHAPDI_00705 1.9e-294 trpE 4.1.3.27 EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MNLHAPDI_00706 1e-63 aroH 2.7.4.25, 5.4.99.5 E Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis
MNLHAPDI_00707 8.1e-207 aroB 2.7.1.71, 4.2.3.4 E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MNLHAPDI_00708 5.5e-217 aroC 4.2.3.5 E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MNLHAPDI_00709 2.9e-142 cheR 2.1.1.80 NT COG1352 Methylase of chemotaxis methyl-accepting proteins
MNLHAPDI_00710 9.1e-80 ndk 2.7.4.6 F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
MNLHAPDI_00711 4.5e-194 hepT 2.5.1.30, 2.5.1.83, 2.5.1.90 H Belongs to the FPP GGPP synthase family
MNLHAPDI_00712 8.6e-133 menG 2.1.1.163, 2.1.1.201 H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)
MNLHAPDI_00713 5.6e-138 hepS 2.5.1.30 H Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1
MNLHAPDI_00714 2.3e-34 mtrB K Required for transcription attenuation control in the Trp operon. This trans-acting factor seems to recognize a 10 bases nucleotide sequence in the Trp leader transcript causing transcription termination. Binds the leader RNA only in presence of L-tryptophan
MNLHAPDI_00715 7.1e-101 folE 3.5.4.16 H GTP cyclohydrolase
MNLHAPDI_00716 4.7e-42 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
MNLHAPDI_00717 3.7e-279 spoIVA S ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MNLHAPDI_00718 5.4e-138 yphF
MNLHAPDI_00719 1.6e-18 yphE S Protein of unknown function (DUF2768)
MNLHAPDI_00720 2.3e-190 gpsA 1.1.1.94 I Glycerol-3-phosphate dehydrogenase
MNLHAPDI_00721 3.9e-248 der 1.1.1.399, 1.1.1.95 S GTPase that plays an essential role in the late steps of ribosome biogenesis
MNLHAPDI_00722 1.6e-28 ypzH
MNLHAPDI_00723 2.5e-161 seaA S YIEGIA protein
MNLHAPDI_00724 1.3e-102 yphA
MNLHAPDI_00725 1e-07 S YpzI-like protein
MNLHAPDI_00726 4.1e-187 fni 1.1.1.88, 5.3.3.2 C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
MNLHAPDI_00727 4.3e-206 rpsA 1.17.7.4 J Ribosomal protein S1
MNLHAPDI_00728 1.9e-113 cmk 1.17.7.4, 2.5.1.19, 2.7.1.26, 2.7.4.25, 2.7.7.2, 6.3.2.1 F Belongs to the cytidylate kinase family. Type 1 subfamily
MNLHAPDI_00729 1.8e-23 S Family of unknown function (DUF5359)
MNLHAPDI_00730 9.2e-113 ypfA M Flagellar protein YcgR
MNLHAPDI_00731 6.5e-254 hemX 2.1.1.107, 4.2.1.75 H sporulation protein
MNLHAPDI_00732 4.7e-155 sleB 3.5.1.28 M Spore cortex-lytic enzyme
MNLHAPDI_00733 1e-119 prsW S Involved in the degradation of specific anti-sigma factors
MNLHAPDI_00734 1.6e-174 ypdA 1.18.1.2, 1.19.1.1, 1.8.1.9 O COG0492 Thioredoxin reductase
MNLHAPDI_00735 2.6e-244 gudB 1.4.1.2, 1.4.1.3 E Belongs to the Glu Leu Phe Val dehydrogenases family
MNLHAPDI_00736 2.4e-104 mecB NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC
MNLHAPDI_00737 1.8e-147 ypbG S Calcineurin-like phosphoesterase superfamily domain
MNLHAPDI_00738 2.8e-81 ypbF S Protein of unknown function (DUF2663)
MNLHAPDI_00739 4.6e-81 ypbE M Lysin motif
MNLHAPDI_00740 2.2e-100 ypbD S metal-dependent membrane protease
MNLHAPDI_00741 3.2e-286 recQ 3.6.4.12 L DNA helicase
MNLHAPDI_00742 3.8e-201 ypbB 5.1.3.1 S protein conserved in bacteria
MNLHAPDI_00743 4.7e-41 fer C Ferredoxin
MNLHAPDI_00744 5.8e-87 fmnP U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
MNLHAPDI_00745 1.5e-294 serA 1.1.1.399, 1.1.1.95 E Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MNLHAPDI_00746 9e-136 aroD 1.1.1.25, 4.2.1.10 E Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
MNLHAPDI_00747 6.8e-201 rsiX
MNLHAPDI_00748 2.6e-103 sigX K Belongs to the sigma-70 factor family. ECF subfamily
MNLHAPDI_00749 0.0 resE 2.7.13.3 T Histidine kinase
MNLHAPDI_00750 6.7e-133 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MNLHAPDI_00751 3.9e-215 ccsA O 'COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component'
MNLHAPDI_00752 0.0 ccs1 O COG1333 ResB protein required for cytochrome c biosynthesis
MNLHAPDI_00753 1.3e-99 resA CO Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c
MNLHAPDI_00754 6.9e-133 rluB 5.4.99.19, 5.4.99.21, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
MNLHAPDI_00755 1.9e-87 spmB S Spore maturation protein
MNLHAPDI_00756 3.5e-103 spmA S Spore maturation protein
MNLHAPDI_00757 4.7e-213 dacB 3.4.16.4 M Belongs to the peptidase S11 family
MNLHAPDI_00758 4e-98 ypuI S Protein of unknown function (DUF3907)
MNLHAPDI_00759 1.9e-104 scpB D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MNLHAPDI_00760 4.5e-130 scpA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MNLHAPDI_00761 1.7e-93 ypuF S Domain of unknown function (DUF309)
MNLHAPDI_00762 4.5e-64 ribT K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
MNLHAPDI_00763 3.9e-81 ribH 2.5.1.78 H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
MNLHAPDI_00764 9.8e-230 ribBA 3.5.4.25, 4.1.99.12 H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MNLHAPDI_00765 1.5e-115 ribE 2.5.1.9 H Riboflavin synthase
MNLHAPDI_00766 4.9e-204 ribD 1.1.1.193, 3.5.4.26 H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MNLHAPDI_00767 7.8e-55 ypuD
MNLHAPDI_00768 6.2e-94 sipT 3.4.21.89 U Belongs to the peptidase S26 family
MNLHAPDI_00769 2.3e-33 yhcC S nucleic-acid-binding protein containing a Zn-ribbon domain
MNLHAPDI_00770 7.3e-17 S SNARE associated Golgi protein
MNLHAPDI_00774 8e-81 ppiB 5.2.1.8 O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MNLHAPDI_00775 8.1e-149 ypuA S Secreted protein
MNLHAPDI_00776 5.2e-256 lysA 4.1.1.19, 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
MNLHAPDI_00777 1.4e-273 spoVAF EG Stage V sporulation protein AF
MNLHAPDI_00778 1.4e-110 spoVAEA S stage V sporulation protein
MNLHAPDI_00779 2.2e-57 spoVAEB S stage V sporulation protein
MNLHAPDI_00780 9e-192 spoVAD I Stage V sporulation protein AD
MNLHAPDI_00781 2.3e-78 spoVAC S stage V sporulation protein AC
MNLHAPDI_00782 1e-67 spoVAB S Stage V sporulation protein AB
MNLHAPDI_00783 7.4e-112 spoVAA S Stage V sporulation protein AA
MNLHAPDI_00784 2.4e-136 sigF K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MNLHAPDI_00785 1.8e-75 spoIIAB 2.7.11.1 F Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition
MNLHAPDI_00786 3.9e-57 spoIIAA T Belongs to the anti-sigma-factor antagonist family
MNLHAPDI_00787 2.8e-213 dacF 3.4.16.4 M Belongs to the peptidase S11 family
MNLHAPDI_00788 1.7e-148 punA 2.4.2.1 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MNLHAPDI_00789 1.2e-232 deoB 5.4.2.7 G Phosphotransfer between the C1 and C5 carbon atoms of pentose
MNLHAPDI_00790 2.6e-166 xerD L recombinase XerD
MNLHAPDI_00791 3.7e-37 S Protein of unknown function (DUF4227)
MNLHAPDI_00792 2.4e-80 fur P Belongs to the Fur family
MNLHAPDI_00793 2.3e-108 spoIIM S Required for complete septum migration and engulfment of the forespore compartment during sporulation. Required for stabilizing and recruiting of SpoIIP to the septal membrane
MNLHAPDI_00794 2.2e-31 yqkK
MNLHAPDI_00795 5.5e-242 mleA 1.1.1.38 C malic enzyme
MNLHAPDI_00796 2.7e-234 mleN C Na H antiporter
MNLHAPDI_00797 4.9e-268 aspA 4.2.1.2, 4.3.1.1 E Aspartate ammonia-lyase
MNLHAPDI_00798 2.3e-184 ansA 3.5.1.1 EJ L-asparaginase
MNLHAPDI_00799 4.5e-58 ansR K Transcriptional regulator
MNLHAPDI_00800 1.4e-220 yqxK 3.6.4.12 L DNA helicase
MNLHAPDI_00801 1.2e-92 nudF 3.6.1.13 L Belongs to the Nudix hydrolase family
MNLHAPDI_00803 7.4e-169 yqkF C oxidoreductases (related to aryl-alcohol dehydrogenases)
MNLHAPDI_00804 3.1e-12 yqkE S Protein of unknown function (DUF3886)
MNLHAPDI_00805 8.5e-173 yqkD S COG1073 Hydrolases of the alpha beta superfamily
MNLHAPDI_00806 9.4e-39 yqkC S Protein of unknown function (DUF2552)
MNLHAPDI_00807 2.8e-54 yqkB S Belongs to the HesB IscA family
MNLHAPDI_00808 7.5e-194 yqkA K GrpB protein
MNLHAPDI_00809 2e-58 yqjZ 2.3.1.128, 2.5.1.18 S enzyme involved in biosynthesis of extracellular polysaccharides
MNLHAPDI_00810 1.8e-86 yqjY K acetyltransferase
MNLHAPDI_00811 2.2e-49 S YolD-like protein
MNLHAPDI_00812 3.1e-239 polYB 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MNLHAPDI_00814 6.1e-222 yqjV G Major Facilitator Superfamily
MNLHAPDI_00816 2.1e-72 yqjT 3.1.26.4 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
MNLHAPDI_00817 1.2e-177 coaA 2.7.1.33 F Pantothenic acid kinase
MNLHAPDI_00818 6e-260 dsdA 4.3.1.18 E Belongs to the serine threonine dehydratase family. DsdA subfamily
MNLHAPDI_00819 1e-142 yqjQ S Belongs to the short-chain dehydrogenases reductases (SDR) family
MNLHAPDI_00820 1.3e-179 yqjP S COG0491 Zn-dependent hydrolases, including glyoxylases
MNLHAPDI_00821 8.6e-148 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MNLHAPDI_00822 0.0 rocB E arginine degradation protein
MNLHAPDI_00823 1.4e-192 namA 1.6.99.1 C Catalyzes the reduction of the double bond of an array of alpha,beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes
MNLHAPDI_00824 9.6e-146 yqjL S hydrolases or acyltransferases (alpha beta hydrolase superfamily)
MNLHAPDI_00825 2.9e-173 rnz 3.1.26.11 S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
MNLHAPDI_00826 2.6e-288 zwf 1.1.1.363, 1.1.1.49 G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MNLHAPDI_00827 6.9e-267 gnd 1.1.1.343, 1.1.1.44 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MNLHAPDI_00828 1.6e-235 dinB 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MNLHAPDI_00829 4.5e-24 yqzJ
MNLHAPDI_00830 5.7e-144 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
MNLHAPDI_00831 8.9e-141 yqjF S Uncharacterized conserved protein (COG2071)
MNLHAPDI_00832 1.6e-202 yqjE 3.4.11.4 E COG2195 Di- and tripeptidases
MNLHAPDI_00833 3.8e-287 mmdA 2.1.3.15, 6.4.1.3 I COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
MNLHAPDI_00834 8.7e-72 mce 4.4.1.5, 5.1.99.1, 5.4.99.2 E COG0346 Lactoylglutathione lyase and related lyases
MNLHAPDI_00836 1.4e-98 yqjB S protein conserved in bacteria
MNLHAPDI_00837 3.3e-175 yqjA S Putative aromatic acid exporter C-terminal domain
MNLHAPDI_00838 4.5e-129 artM 3.6.3.21 E COG1126 ABC-type polar amino acid transport system, ATPase component
MNLHAPDI_00839 6.2e-109 artQ E COG0765 ABC-type amino acid transport system, permease component
MNLHAPDI_00840 4.1e-136 artP ET Belongs to the bacterial solute-binding protein 3 family
MNLHAPDI_00841 9.3e-77 yqiW S Belongs to the UPF0403 family
MNLHAPDI_00842 8.8e-167 yegS 2.7.1.107 I COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
MNLHAPDI_00843 7.9e-208 norA EGP Major facilitator Superfamily
MNLHAPDI_00844 2.6e-152 bmrR K helix_turn_helix, mercury resistance
MNLHAPDI_00845 3.5e-233 bfmBB 2.3.1.168, 2.3.1.61 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
MNLHAPDI_00846 1.8e-184 bfmBAB 1.2.4.1, 1.2.4.4 C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
MNLHAPDI_00847 1.9e-186 bfmBAA 1.2.4.4 C COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
MNLHAPDI_00848 3.4e-269 lpdA 1.8.1.4 C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
MNLHAPDI_00849 1.2e-202 buk 2.7.2.7 C Belongs to the acetokinase family
MNLHAPDI_00850 2.2e-207 ldh 1.4.1.9 E Belongs to the Glu Leu Phe Val dehydrogenases family
MNLHAPDI_00851 5.1e-154 pta 2.3.1.19, 2.3.1.8 C phosphate butyryltransferase
MNLHAPDI_00852 0.0 bkdR 2.7.13.3 KT Transcriptional regulator
MNLHAPDI_00853 4e-34 yqzF S Protein of unknown function (DUF2627)
MNLHAPDI_00854 3e-162 prpB 4.1.3.30 G Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MNLHAPDI_00855 2.2e-276 prpD 4.2.1.79 S 2-methylcitrate dehydratase
MNLHAPDI_00856 8.1e-210 prpC 2.3.3.1, 2.3.3.5 C Belongs to the citrate synthase family
MNLHAPDI_00857 1.8e-212 mmgC I acyl-CoA dehydrogenase
MNLHAPDI_00858 4.7e-157 hbdA 1.1.1.157 I Dehydrogenase
MNLHAPDI_00859 1.2e-219 mmgA 2.3.1.9 I Belongs to the thiolase family
MNLHAPDI_00860 1.8e-133 yqiK 3.1.4.46 C glycerophosphoryl diester phosphodiesterase
MNLHAPDI_00861 5.4e-107 amiC 3.5.1.28 M Cell wall hydrolase autolysin
MNLHAPDI_00862 5.9e-27
MNLHAPDI_00863 1.3e-215 yqiG C COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family
MNLHAPDI_00865 3.2e-144 KT May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process
MNLHAPDI_00866 1.2e-238 rseP 3.4.21.116 M Stage IV sporulation protein B
MNLHAPDI_00867 0.0 recN L May be involved in recombinational repair of damaged DNA
MNLHAPDI_00868 1.7e-78 argR K Regulates arginine biosynthesis genes
MNLHAPDI_00869 6.6e-156 rrmJ 2.1.1.226, 2.1.1.227 J rRNA methylase
MNLHAPDI_00870 0.0 dxs 2.2.1.7 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MNLHAPDI_00871 7.7e-163 ispA 2.5.1.1, 2.5.1.10, 2.5.1.29, 2.5.1.90 H Belongs to the FPP GGPP synthase family
MNLHAPDI_00872 5.8e-39 xseB 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
MNLHAPDI_00873 2.2e-246 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
MNLHAPDI_00874 1e-156 folD 1.5.1.5, 3.5.4.9 F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MNLHAPDI_00875 1.9e-65 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MNLHAPDI_00876 2.1e-67 yqhY S protein conserved in bacteria
MNLHAPDI_00877 1.5e-255 accC 6.3.4.14, 6.4.1.2 I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
MNLHAPDI_00878 1.5e-64 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
MNLHAPDI_00879 9.9e-91 spoIIIAH S SpoIIIAH-like protein
MNLHAPDI_00880 6.9e-103 spoIIIAG S stage III sporulation protein AG
MNLHAPDI_00881 3.1e-102 spoIIIAF S Stage III sporulation protein AF (Spore_III_AF)
MNLHAPDI_00882 1.3e-197 spoIIIAE S stage III sporulation protein AE
MNLHAPDI_00883 2.3e-58 spoIIIAD S Stage III sporulation protein AD
MNLHAPDI_00884 7.6e-29 spoIIIAC S stage III sporulation protein AC
MNLHAPDI_00885 2.9e-85 spoIIIAB S Stage III sporulation protein
MNLHAPDI_00886 1.2e-171 spoIIIAA S stage III sporulation protein AA
MNLHAPDI_00887 7.9e-37 yqhV S Protein of unknown function (DUF2619)
MNLHAPDI_00888 5.4e-98 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MNLHAPDI_00889 8.9e-174 yqhT 3.4.11.9, 3.4.13.9 E COG0006 Xaa-Pro aminopeptidase
MNLHAPDI_00890 1.5e-77 aroQ 4.2.1.10 E Catalyzes a trans-dehydration via an enolate intermediate
MNLHAPDI_00891 2.3e-93 yqhR S Conserved membrane protein YqhR
MNLHAPDI_00892 2.1e-174 yqhQ S Protein of unknown function (DUF1385)
MNLHAPDI_00893 2.2e-61 yqhP
MNLHAPDI_00894 8.1e-165 yqhO S esterase of the alpha-beta hydrolase superfamily
MNLHAPDI_00895 9.4e-74 mntR K Involved in manganese homeostasis. Might activate the transcription of the mntABCD operon
MNLHAPDI_00896 5.2e-161 lipM 6.3.1.20 H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation
MNLHAPDI_00897 2.3e-63 yqhL P COG0607 Rhodanese-related sulfurtransferase
MNLHAPDI_00898 1e-284 gcvPB 1.4.4.2 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MNLHAPDI_00899 1.7e-254 gcvPA 1.4.4.2 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MNLHAPDI_00900 5.3e-206 gcvT 1.4.4.2, 2.1.2.10 E The glycine cleavage system catalyzes the degradation of glycine
MNLHAPDI_00901 0.0 yqhH L COG0553 Superfamily II DNA RNA helicases, SNF2 family
MNLHAPDI_00902 3.2e-152 yqhG S Bacterial protein YqhG of unknown function
MNLHAPDI_00903 1.2e-24 sinI S Anti-repressor SinI
MNLHAPDI_00904 1e-54 sinR K transcriptional
MNLHAPDI_00905 2.5e-141 tasA S Cell division protein FtsN
MNLHAPDI_00906 1.9e-58 sipW 3.4.21.89 U Signal peptidase
MNLHAPDI_00907 1.3e-113 yqxM
MNLHAPDI_00908 7.3e-54 yqzG S Protein of unknown function (DUF3889)
MNLHAPDI_00909 4.4e-25 yqzE S YqzE-like protein
MNLHAPDI_00910 1.8e-44 S ComG operon protein 7
MNLHAPDI_00911 1.4e-33 comGF U Putative Competence protein ComGF
MNLHAPDI_00912 1.3e-57 comGE
MNLHAPDI_00913 7.7e-68 gspH NU protein transport across the cell outer membrane
MNLHAPDI_00914 5.2e-47 comGC U Required for transformation and DNA binding
MNLHAPDI_00915 2.3e-174 comGB NU COG1459 Type II secretory pathway, component PulF
MNLHAPDI_00916 3.9e-201 comGA NU COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MNLHAPDI_00919 7.2e-175 corA P Mg2 transporter protein
MNLHAPDI_00920 7.5e-239 corC1 S COG1253 Hemolysins and related proteins containing CBS domains
MNLHAPDI_00921 7e-150 yqhA T COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
MNLHAPDI_00923 2.7e-64 yqgZ 1.20.4.1 P Belongs to the ArsC family
MNLHAPDI_00924 1.8e-37 yqgY S Protein of unknown function (DUF2626)
MNLHAPDI_00925 1.2e-122 ycbL 3.1.2.6 S COG0491 Zn-dependent hydrolases, including glyoxylases
MNLHAPDI_00926 8.9e-23 yqgW S Protein of unknown function (DUF2759)
MNLHAPDI_00927 6.9e-50 yqgV S Thiamine-binding protein
MNLHAPDI_00928 3.9e-198 yqgU
MNLHAPDI_00929 2.4e-222 yqgT 3.4.19.11 E Gamma-D-glutamyl-L-diamino acid endopeptidase
MNLHAPDI_00930 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
MNLHAPDI_00931 5.2e-181 glcK 2.7.1.2 G Glucokinase
MNLHAPDI_00932 3.1e-33 yqgQ S Protein conserved in bacteria
MNLHAPDI_00933 1.4e-268 gluP 3.4.21.105 O membrane protein (homolog of Drosophila rhomboid)
MNLHAPDI_00934 2.5e-09 yqgO
MNLHAPDI_00935 2e-103 ygfA 6.3.3.2 H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MNLHAPDI_00936 9.4e-21 rpmG J Belongs to the bacterial ribosomal protein bL33 family
MNLHAPDI_00937 5.1e-201 yqgM 2.4.1.11, 2.4.1.18 GH57,GT4 M Glycosyl transferases group 1
MNLHAPDI_00939 3.5e-50 yqzD
MNLHAPDI_00940 7.3e-72 yqzC S YceG-like family
MNLHAPDI_00941 3.7e-145 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
MNLHAPDI_00942 6.4e-148 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
MNLHAPDI_00943 4.4e-158 pstA P Phosphate transport system permease
MNLHAPDI_00944 7.1e-159 pstC P probably responsible for the translocation of the substrate across the membrane
MNLHAPDI_00945 2e-150 pstS P Phosphate
MNLHAPDI_00946 0.0 pbpA 3.4.16.4 M penicillin-binding protein
MNLHAPDI_00947 2.5e-231 yqgE EGP Major facilitator superfamily
MNLHAPDI_00948 6.3e-116 sodA 1.15.1.1 P radicals which are normally produced within the cells and which are toxic to biological systems
MNLHAPDI_00949 4e-73 yqgC S protein conserved in bacteria
MNLHAPDI_00950 1.5e-130 yqgB S Protein of unknown function (DUF1189)
MNLHAPDI_00951 1.2e-46 yqfZ M LysM domain
MNLHAPDI_00952 2.8e-202 ispG 1.17.7.1, 1.17.7.3 I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MNLHAPDI_00953 4.3e-62 yqfX S membrane
MNLHAPDI_00954 1.2e-108 yqfW S Belongs to the 5'(3')-deoxyribonucleotidase family
MNLHAPDI_00955 4.2e-77 zur P Belongs to the Fur family
MNLHAPDI_00956 1.6e-157 yqfU S Uncharacterized protein conserved in bacteria (DUF2179)
MNLHAPDI_00957 2.1e-36 yqfT S Protein of unknown function (DUF2624)
MNLHAPDI_00958 5.7e-166 nfo 3.1.21.2 L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MNLHAPDI_00959 1.9e-242 cshB 3.6.4.13 JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
MNLHAPDI_00961 2.6e-177 ispH 1.17.7.4, 2.7.4.25 IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MNLHAPDI_00962 1.9e-211 yqfO 3.5.4.16 S Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MNLHAPDI_00963 6.1e-117 trmK 2.1.1.217 S SAM-dependent methyltransferase
MNLHAPDI_00964 1.6e-61 cccA C COG2010 Cytochrome c, mono- and diheme variants
MNLHAPDI_00965 1.2e-200 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
MNLHAPDI_00966 0.0 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
MNLHAPDI_00967 4.5e-88 yaiI S Belongs to the UPF0178 family
MNLHAPDI_00968 5.8e-149 yqfL 2.7.11.33, 2.7.4.28 S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation
MNLHAPDI_00969 4.5e-112 ccpN K CBS domain
MNLHAPDI_00970 0.0 glyS 6.1.1.14 J Glycyl-tRNA synthetase beta subunit
MNLHAPDI_00971 3.3e-174 glyQ 6.1.1.14 J glycyl-tRNA synthetase alpha subunit
MNLHAPDI_00972 4.8e-145 recO L Involved in DNA repair and RecF pathway recombination
MNLHAPDI_00973 8.4e-19 S YqzL-like protein
MNLHAPDI_00974 3.1e-167 era S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MNLHAPDI_00975 2.1e-70 cdd 2.4.2.2, 3.5.4.5 F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
MNLHAPDI_00976 1.8e-60 dgkA 2.7.1.107, 2.7.1.66 M Diacylglycerol kinase
MNLHAPDI_00977 2e-80 ybeY 2.6.99.2, 3.5.4.5 S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MNLHAPDI_00978 0.0 yqfF S membrane-associated HD superfamily hydrolase
MNLHAPDI_00980 2.5e-175 phoH T Phosphate starvation-inducible protein PhoH
MNLHAPDI_00981 1.5e-185 yqfD 3.1.3.102, 3.1.3.104 S Stage IV sporulation
MNLHAPDI_00982 2.7e-45 yqfC S sporulation protein YqfC
MNLHAPDI_00983 3.7e-22 yqfB
MNLHAPDI_00984 4.3e-122 yqfA S UPF0365 protein
MNLHAPDI_00985 4.5e-228 yqeZ O COG1030 Membrane-bound serine protease (ClpP class)
MNLHAPDI_00986 2.5e-61 yqeY S Yqey-like protein
MNLHAPDI_00987 1.2e-19 rpsU J Belongs to the bacterial ribosomal protein bS21 family
MNLHAPDI_00988 8.2e-158 yqeW P COG1283 Na phosphate symporter
MNLHAPDI_00989 2.1e-260 yqeV 2.8.4.5 J ribosomal protein S12 methylthiotransferase
MNLHAPDI_00990 9.4e-141 rsmE 2.1.1.193 J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
MNLHAPDI_00991 6e-174 prmA J Methylates ribosomal protein L11
MNLHAPDI_00992 4.2e-182 dnaJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
MNLHAPDI_00993 0.0 dnaK O Heat shock 70 kDa protein
MNLHAPDI_00994 3.8e-75 grpE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MNLHAPDI_00995 4.7e-188 hrcA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
MNLHAPDI_00996 7e-217 hemN H Involved in the biosynthesis of porphyrin-containing compound
MNLHAPDI_00997 0.0 lepA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
MNLHAPDI_00998 7.2e-53 yqxA S Protein of unknown function (DUF3679)
MNLHAPDI_00999 2e-222 spoIIP M stage II sporulation protein P
MNLHAPDI_01000 5e-204 gpr 3.4.24.78 C Initiates the rapid degradation of small, acid-soluble proteins during spore germination
MNLHAPDI_01001 9.7e-37 rpsT J Binds directly to 16S ribosomal RNA
MNLHAPDI_01002 5.6e-189 holA 2.7.7.7 L DNA polymerase III delta subunit
MNLHAPDI_01003 4.1e-15 S YqzM-like protein
MNLHAPDI_01004 0.0 comEC S Competence protein ComEC
MNLHAPDI_01005 2.1e-105 comEB 3.5.4.12 F ComE operon protein 2
MNLHAPDI_01006 3e-105 wza L COG1555 DNA uptake protein and related DNA-binding proteins
MNLHAPDI_01007 2.5e-147 comER E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MNLHAPDI_01008 2.9e-139 yqeM Q Methyltransferase
MNLHAPDI_01009 3.4e-61 rsfS J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
MNLHAPDI_01010 3.7e-102 nadD 2.7.6.3, 2.7.7.18 H HD superfamily hydrolase involved in NAD metabolism
MNLHAPDI_01011 2.7e-108 nadD 2.7.7.18, 3.6.1.55 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MNLHAPDI_01012 2.1e-45 yhbY J RNA-binding protein containing KH domain, possibly ribosomal protein
MNLHAPDI_01013 5.1e-156 aroE 1.1.1.25 E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MNLHAPDI_01014 9.1e-214 yqeH S In Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis
MNLHAPDI_01015 5.3e-95 yqeG S hydrolase of the HAD superfamily
MNLHAPDI_01017 6.2e-142 yqeF E GDSL-like Lipase/Acylhydrolase
MNLHAPDI_01018 1.7e-131 xlyA 3.5.1.28 M n-acetylmuramoyl-L-alanine amidase
MNLHAPDI_01019 2.3e-105 yqeD S SNARE associated Golgi protein
MNLHAPDI_01020 3.8e-170 gnd 1.1.1.343, 1.1.1.44 G 6-phosphogluconate dehydrogenase
MNLHAPDI_01021 2.3e-133 yqeB
MNLHAPDI_01022 1.1e-74 nucB M Deoxyribonuclease NucA/NucB
MNLHAPDI_01023 3.1e-125 sigK K sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MNLHAPDI_01024 4.2e-64 K BetI-type transcriptional repressor, C-terminal
MNLHAPDI_01025 4.6e-140 yhfP 1.1.1.1 C Alcohol dehydrogenase GroES-like domain
MNLHAPDI_01026 1.3e-22 L Helix-turn-helix domain of resolvase
MNLHAPDI_01027 4e-77 arsC 1.20.4.1 T Catalyzes the reduction of arsenate As(V) to arsenite As(III)
MNLHAPDI_01028 8.7e-182 arsB 1.20.4.1 P Arsenic resistance protein
MNLHAPDI_01029 3.7e-65 cadI 4.4.1.5 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
MNLHAPDI_01030 2.1e-54 arsR K ArsR family transcriptional regulator
MNLHAPDI_01033 1.4e-156 S Aspartate phosphatase response regulator
MNLHAPDI_01034 1.3e-138 yvgN 1.1.1.346 S Reductase
MNLHAPDI_01035 1e-70 K MerR family transcriptional regulator
MNLHAPDI_01036 1.2e-272 L nucleic acid phosphodiester bond hydrolysis
MNLHAPDI_01038 3.2e-123 xlyA 3.5.1.28 M N-acetylmuramoyl-L-alanine amidase
MNLHAPDI_01039 1.3e-27 S phage terminase, large subunit
MNLHAPDI_01040 6.6e-19 yqaS L DNA packaging
MNLHAPDI_01041 6.3e-34 yqaS L DNA packaging
MNLHAPDI_01043 8.2e-109 S SEC-C Motif Domain Protein
MNLHAPDI_01046 6.1e-21 ydaT
MNLHAPDI_01047 6.1e-28
MNLHAPDI_01049 1.1e-72 L Transposase
MNLHAPDI_01051 1.4e-18 wapA M RHS family
MNLHAPDI_01052 2.1e-31 yqaO S Phage-like element PBSX protein XtrA
MNLHAPDI_01053 1.9e-53 rusA L Endodeoxyribonuclease RusA
MNLHAPDI_01056 7.6e-160 axeA S Carbohydrate esterase, sialic acid-specific acetylesterase
MNLHAPDI_01057 2e-89 K Transcriptional regulator PadR-like family
MNLHAPDI_01058 1.3e-96 adk 2.7.4.3 F adenylate kinase activity
MNLHAPDI_01060 1.4e-26 yqaB E IrrE N-terminal-like domain
MNLHAPDI_01061 2.2e-167 iolT EGP Major facilitator Superfamily
MNLHAPDI_01062 4e-133 G AP endonuclease family 2 C terminus
MNLHAPDI_01063 7.4e-101 IQ Enoyl-(Acyl carrier protein) reductase
MNLHAPDI_01064 1.2e-71 K PFAM Periplasmic binding protein LacI transcriptional regulator
MNLHAPDI_01065 5.4e-112 yrkJ S membrane transporter protein
MNLHAPDI_01066 3.5e-35 yrkI O Belongs to the sulfur carrier protein TusA family
MNLHAPDI_01067 9.3e-206 yrkH P Rhodanese Homology Domain
MNLHAPDI_01069 4.2e-98 yrkF OP Belongs to the sulfur carrier protein TusA family
MNLHAPDI_01070 5.6e-83 yrkE O DsrE/DsrF/DrsH-like family
MNLHAPDI_01071 7.8e-39 yrkD S protein conserved in bacteria
MNLHAPDI_01072 5.5e-106 yrkC G Cupin domain
MNLHAPDI_01073 4.2e-147 bltR K helix_turn_helix, mercury resistance
MNLHAPDI_01074 3.9e-210 blt EGP Major facilitator Superfamily
MNLHAPDI_01075 5.9e-82 bltD 2.3.1.57 K FR47-like protein
MNLHAPDI_01076 2.5e-234 corC1 S COG1253 Hemolysins and related proteins containing CBS domains
MNLHAPDI_01077 3.9e-16 S YrzO-like protein
MNLHAPDI_01078 1.6e-169 yrdR EG EamA-like transporter family
MNLHAPDI_01079 3e-159 yrdQ K Transcriptional regulator
MNLHAPDI_01080 2.3e-198 trkA P Oxidoreductase
MNLHAPDI_01081 4e-149 czcD P COG1230 Co Zn Cd efflux system component
MNLHAPDI_01082 1.3e-66 yodA S tautomerase
MNLHAPDI_01083 5e-162 gltR K LysR substrate binding domain
MNLHAPDI_01084 5.6e-226 brnQ E Component of the transport system for branched-chain amino acids
MNLHAPDI_01085 5.6e-50 azlD E Branched-chain amino acid transport protein (AzlD)
MNLHAPDI_01086 1.8e-136 azlC E AzlC protein
MNLHAPDI_01087 6.3e-79 bkdR K helix_turn_helix ASNC type
MNLHAPDI_01088 1.2e-15 yrdF K ribonuclease inhibitor
MNLHAPDI_01089 2e-225 cypA C Cytochrome P450
MNLHAPDI_01090 1.9e-23 K Acetyltransferase (GNAT) family
MNLHAPDI_01092 5e-99 yrdC 3.5.1.19 Q Isochorismatase family
MNLHAPDI_01093 5.6e-54 S Protein of unknown function (DUF2568)
MNLHAPDI_01094 2.4e-89 yrdA S DinB family
MNLHAPDI_01095 9.3e-166 aadK G Streptomycin adenylyltransferase
MNLHAPDI_01096 3.2e-192 yrpB 1.13.12.16 S COG2070 Dioxygenases related to 2-nitropropane dioxygenase
MNLHAPDI_01097 4.8e-148 murI 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
MNLHAPDI_01098 1.6e-123 yrpD S Domain of unknown function, YrpD
MNLHAPDI_01100 5.4e-117 adcA S ZinT (YodA) periplasmic lipocalin-like zinc-recruitment
MNLHAPDI_01101 2.4e-95 sigZ K Belongs to the sigma-70 factor family. ECF subfamily
MNLHAPDI_01102 1.7e-131 yrpG C Aldo/keto reductase family
MNLHAPDI_01103 1.2e-47 yrpG C Aldo/keto reductase family
MNLHAPDI_01104 9.5e-226 yraO C Citrate transporter
MNLHAPDI_01105 3.4e-163 yraN K Transcriptional regulator
MNLHAPDI_01106 1.6e-205 yraM S PrpF protein
MNLHAPDI_01107 2.7e-157 csn 3.2.1.132 M Aids in the defense against invading fungal pathogens by degrading their cell wall chitosan
MNLHAPDI_01108 6.4e-41 yraL S COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MNLHAPDI_01109 1e-153 S Alpha beta hydrolase
MNLHAPDI_01110 4.9e-60 T sh3 domain protein
MNLHAPDI_01111 2.4e-61 T sh3 domain protein
MNLHAPDI_01113 3.8e-66 E Glyoxalase-like domain
MNLHAPDI_01114 1.5e-36 yraG
MNLHAPDI_01115 6.4e-63 yraF M Spore coat protein
MNLHAPDI_01116 2.9e-223 adhB 1.1.1.1, 1.1.1.14, 1.1.1.284, 1.2.1.46 E COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
MNLHAPDI_01117 2.6e-26 yraE
MNLHAPDI_01118 1.1e-49 yraD M Spore coat protein
MNLHAPDI_01119 4.3e-47 yraB K helix_turn_helix, mercury resistance
MNLHAPDI_01120 2.1e-28 yphJ 4.1.1.44 S peroxiredoxin activity
MNLHAPDI_01121 3.5e-199 adhA 1.1.1.1 C alcohol dehydrogenase
MNLHAPDI_01122 5e-90 yhbO 1.11.1.6, 3.5.1.124 S protease
MNLHAPDI_01123 0.0 sacC 3.2.1.26, 3.2.1.65, 3.2.1.80 GH32 G Belongs to the glycosyl hydrolase 32 family
MNLHAPDI_01124 1.5e-152 manZ G COG3716 Phosphotransferase system, mannose fructose N-acetylgalactosamine-specific component IID
MNLHAPDI_01125 4.9e-116 manY G COG3715 Phosphotransferase system, mannose fructose N-acetylgalactosamine-specific component IIC
MNLHAPDI_01126 6.9e-81 levE 2.7.1.202 G PTS system mannose fructose sorbose family
MNLHAPDI_01127 1.9e-74 levD 2.7.1.202 G PTS system fructose IIA component
MNLHAPDI_01128 0.0 levR K PTS system fructose IIA component
MNLHAPDI_01129 1e-254 cycA E COG1113 Gamma-aminobutyrate permease and related permeases
MNLHAPDI_01130 3.6e-106 yrhP E LysE type translocator
MNLHAPDI_01131 1.6e-149 yrhO K Archaeal transcriptional regulator TrmB
MNLHAPDI_01132 1.6e-85 sigV K Belongs to the sigma-70 factor family. ECF subfamily
MNLHAPDI_01133 3.8e-151 rsiV S Protein of unknown function (DUF3298)
MNLHAPDI_01134 0.0 yrhL I Acyltransferase family
MNLHAPDI_01135 1.5e-46 yrhK S YrhK-like protein
MNLHAPDI_01136 0.0 cypD 1.14.14.1, 1.6.2.4 C Belongs to the cytochrome P450 family
MNLHAPDI_01137 4.8e-105 Z012_03230 K Tetracycline repressor, C-terminal all-alpha domain
MNLHAPDI_01138 4.5e-97 yrhH Q methyltransferase
MNLHAPDI_01141 1.8e-142 focA P Formate nitrite
MNLHAPDI_01142 7.8e-61 yrhF S Uncharacterized conserved protein (DUF2294)
MNLHAPDI_01143 0.0 fdhA 1.17.1.10, 1.17.1.9 C formate dehydrogenase (NAD+) activity
MNLHAPDI_01144 1.4e-78 yrhD S Protein of unknown function (DUF1641)
MNLHAPDI_01145 4.6e-35 yrhC S YrhC-like protein
MNLHAPDI_01146 2.6e-211 mccB 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
MNLHAPDI_01147 1.2e-171 mccA 2.5.1.134, 2.5.1.47 E Cysteine synthase
MNLHAPDI_01148 4.2e-124 mtnN 3.2.2.9 E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MNLHAPDI_01149 1.2e-120 yrrT 4.4.1.21 Q Could be a S-adenosyl-L-methionine-dependent methyltransferase
MNLHAPDI_01150 3.5e-26 yrzA S Protein of unknown function (DUF2536)
MNLHAPDI_01151 4.2e-63 yrrS S Protein of unknown function (DUF1510)
MNLHAPDI_01152 0.0 pbpI 3.4.16.4 M Penicillin-binding Protein
MNLHAPDI_01153 2.4e-78 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
MNLHAPDI_01154 4.7e-114 udk 2.7.1.48 F Cytidine monophosphokinase
MNLHAPDI_01155 2.7e-246 yegQ O COG0826 Collagenase and related proteases
MNLHAPDI_01156 7.8e-174 yegQ O Peptidase U32
MNLHAPDI_01157 5.9e-120 yrrM 2.1.1.104 S O-methyltransferase
MNLHAPDI_01158 1.6e-183 mltG S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MNLHAPDI_01159 1.2e-45 yrzB S Belongs to the UPF0473 family
MNLHAPDI_01160 2.1e-70 yqgF L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MNLHAPDI_01161 1.7e-41 yrzL S Belongs to the UPF0297 family
MNLHAPDI_01162 0.0 alaS 6.1.1.7 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MNLHAPDI_01163 2.7e-170 yrrI S AI-2E family transporter
MNLHAPDI_01164 8.3e-131 glnQ 3.6.3.21 E COG1126 ABC-type polar amino acid transport system, ATPase component
MNLHAPDI_01165 5.1e-145 glnH ET Belongs to the bacterial solute-binding protein 3 family
MNLHAPDI_01166 3.6e-109 gluC P ABC transporter
MNLHAPDI_01167 7.6e-107 glnP P ABC transporter
MNLHAPDI_01168 8e-08 S Protein of unknown function (DUF3918)
MNLHAPDI_01169 9.8e-31 yrzR
MNLHAPDI_01170 1.8e-83 yrrD S protein conserved in bacteria
MNLHAPDI_01171 0.0 recD2 3.1.11.5 L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
MNLHAPDI_01172 1.4e-15 S COG0457 FOG TPR repeat
MNLHAPDI_01173 2.3e-220 mnmA 2.8.1.13 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
MNLHAPDI_01174 1.4e-212 iscS 2.8.1.7 E Cysteine desulfurase
MNLHAPDI_01175 1.2e-70 cymR K Transcriptional regulator
MNLHAPDI_01176 4.4e-236 rarA L COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase
MNLHAPDI_01177 4e-136 yrvM H COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1
MNLHAPDI_01178 0.0 aspS 6.1.1.12 J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MNLHAPDI_01179 3.4e-244 hisS 6.1.1.21 J histidyl-tRNA synthetase
MNLHAPDI_01181 3.9e-263 lytH 3.5.1.28 M COG3103 SH3 domain protein
MNLHAPDI_01182 2.9e-70 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
MNLHAPDI_01183 0.0 relA 2.7.6.5 KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MNLHAPDI_01184 5.9e-91 apt 2.4.2.22, 2.4.2.7 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MNLHAPDI_01185 0.0 recJ L Single-stranded-DNA-specific exonuclease RecJ
MNLHAPDI_01186 1.3e-48 yrvD S Lipopolysaccharide assembly protein A domain
MNLHAPDI_01187 1.7e-87 yrvC P regulatory, ligand-binding protein related to C-terminal domains of K channels
MNLHAPDI_01188 0.0 secF U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MNLHAPDI_01189 9.4e-49 yrzD S Post-transcriptional regulator
MNLHAPDI_01190 5.7e-270 spoVB S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
MNLHAPDI_01191 2.2e-114 yrbG S membrane
MNLHAPDI_01192 1.2e-74 yrzE S Protein of unknown function (DUF3792)
MNLHAPDI_01193 1.1e-38 yajC U Preprotein translocase subunit YajC
MNLHAPDI_01194 5.2e-228 tgt 2.4.2.29 F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
MNLHAPDI_01195 2e-194 queA 2.4.99.17 J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MNLHAPDI_01196 2.6e-18 yrzS S Protein of unknown function (DUF2905)
MNLHAPDI_01197 6.6e-187 ruvB 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
MNLHAPDI_01198 1.6e-106 ruvA 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
MNLHAPDI_01199 4.8e-93 bofC S BofC C-terminal domain
MNLHAPDI_01200 5.3e-253 csbX EGP Major facilitator Superfamily
MNLHAPDI_01201 1.3e-193 iolG 1.1.1.18, 1.1.1.369 S Oxidoreductase family, NAD-binding Rossmann fold
MNLHAPDI_01202 6.5e-119 yrzF T serine threonine protein kinase
MNLHAPDI_01204 2.6e-35 S Family of unknown function (DUF5412)
MNLHAPDI_01205 1.8e-262 alsT E Sodium alanine symporter
MNLHAPDI_01206 1.9e-127 yebC K transcriptional regulatory protein
MNLHAPDI_01207 3.8e-49 S Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
MNLHAPDI_01208 9.8e-158 safA M spore coat assembly protein SafA
MNLHAPDI_01209 2.8e-215 nadA 2.5.1.72 H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MNLHAPDI_01210 5.4e-161 nadC 1.4.3.16, 2.4.2.19 H Belongs to the NadC ModD family
MNLHAPDI_01211 5.9e-307 nadB 1.3.5.4, 1.4.3.16 H Catalyzes the oxidation of L-aspartate to iminoaspartate
MNLHAPDI_01212 1.2e-230 nifS 2.8.1.7 E Cysteine desulfurase
MNLHAPDI_01213 3.6e-94 niaR S small molecule binding protein (contains 3H domain)
MNLHAPDI_01214 3.4e-163 pheA 4.2.1.51 E Prephenate dehydratase
MNLHAPDI_01215 2.2e-73 pheB 5.4.99.5 S Belongs to the UPF0735 family
MNLHAPDI_01216 1.5e-231 obg S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MNLHAPDI_01217 1.5e-106 spo0B T Sporulation initiation phospho-transferase B, C-terminal
MNLHAPDI_01218 2.5e-46 rpmA J Belongs to the bacterial ribosomal protein bL27 family
MNLHAPDI_01219 4.1e-56 ysxB J ribosomal protein
MNLHAPDI_01220 5.8e-49 rplU J This protein binds to 23S rRNA in the presence of protein L20
MNLHAPDI_01221 9.2e-161 spoIVFB S Stage IV sporulation protein
MNLHAPDI_01222 3.8e-145 spoIVFA M COG0739 Membrane proteins related to metalloendopeptidases
MNLHAPDI_01223 2.5e-144 minD D Belongs to the ParA family
MNLHAPDI_01224 1.4e-108 minC D Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization
MNLHAPDI_01225 1.4e-84 mreD M shape-determining protein
MNLHAPDI_01226 2.8e-157 mreC M Involved in formation and maintenance of cell shape
MNLHAPDI_01227 1.8e-184 mreB D Rod shape-determining protein MreB
MNLHAPDI_01228 5.9e-126 radC E Belongs to the UPF0758 family
MNLHAPDI_01229 2.8e-102 maf D septum formation protein Maf
MNLHAPDI_01230 4e-168 spoIIB S Sporulation related domain
MNLHAPDI_01231 6.6e-85 comC 3.4.23.43 NOU COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases
MNLHAPDI_01232 4.3e-247 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
MNLHAPDI_01233 0.0 valS 6.1.1.9 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
MNLHAPDI_01234 1.6e-25
MNLHAPDI_01235 2.9e-198 ysxE S A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MNLHAPDI_01236 4.3e-202 spoVID M stage VI sporulation protein D
MNLHAPDI_01237 2.3e-248 hemL 5.4.3.8 H Glutamate-1-semialdehyde aminotransferase
MNLHAPDI_01238 5.6e-183 hemB 4.2.1.24 H Belongs to the ALAD family
MNLHAPDI_01239 4.4e-146 hemD 2.1.1.107, 4.2.1.75 H Uroporphyrinogen-III synthase
MNLHAPDI_01240 3e-173 hemC 2.1.1.107, 2.5.1.61, 4.2.1.75 H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
MNLHAPDI_01241 3.6e-146 hemX O cytochrome C
MNLHAPDI_01242 3.5e-247 hemA 1.2.1.70 H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MNLHAPDI_01243 1.4e-89 ysxD
MNLHAPDI_01244 1.2e-106 engB D Necessary for normal cell division and for the maintenance of normal septation
MNLHAPDI_01245 0.0 lon 3.4.21.53 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MNLHAPDI_01246 2.3e-311 lonB 2.7.7.7, 3.4.21.53 LO Belongs to the peptidase S16 family
MNLHAPDI_01247 3.4e-233 clpX O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MNLHAPDI_01248 8.3e-227 tig D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
MNLHAPDI_01249 2.3e-187 ysoA H Tetratricopeptide repeat
MNLHAPDI_01250 8.1e-116 leuD 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MNLHAPDI_01251 1.7e-276 leuC 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MNLHAPDI_01252 3.3e-200 leuB 1.1.1.85 CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
MNLHAPDI_01253 1.9e-289 leuA 2.3.3.13 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MNLHAPDI_01254 3.1e-192 ilvC 1.1.1.86 EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MNLHAPDI_01255 3.2e-84 ilvN 2.2.1.6 E Acetolactate synthase
MNLHAPDI_01256 0.0 ilvB 2.2.1.6 E Acetolactate synthase
MNLHAPDI_01258 7.6e-82 ysnE K acetyltransferase
MNLHAPDI_01259 9.1e-134 ysnF S protein conserved in bacteria
MNLHAPDI_01261 1.4e-92 ysnB S Phosphoesterase
MNLHAPDI_01262 4.5e-103 rdgB 3.6.1.66 F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MNLHAPDI_01263 1.8e-133 rph 2.7.7.56, 3.6.1.66 J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MNLHAPDI_01264 2.9e-196 gerM S COG5401 Spore germination protein
MNLHAPDI_01265 4.3e-152 murI 3.6.1.66, 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
MNLHAPDI_01266 2.3e-75 ysmB 2.4.2.28 K helix_turn_helix multiple antibiotic resistance protein
MNLHAPDI_01267 3.3e-30 gerE K Transcriptional regulator
MNLHAPDI_01268 6.5e-78 ybgC 3.1.2.23, 3.1.2.28 S thioesterase
MNLHAPDI_01269 4.6e-148 sdhB 1.3.5.1, 1.3.5.4 C succinate dehydrogenase
MNLHAPDI_01270 0.0 sdhA 1.3.5.1, 1.3.5.4 C succinate dehydrogenase
MNLHAPDI_01271 2.4e-107 sdhC C succinate dehydrogenase
MNLHAPDI_01272 1.2e-79 yslB S Protein of unknown function (DUF2507)
MNLHAPDI_01273 1.3e-216 lysC 1.1.1.3, 2.7.2.4 E Belongs to the aspartokinase family
MNLHAPDI_01274 0.0 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
MNLHAPDI_01275 2e-52 trxA O Belongs to the thioredoxin family
MNLHAPDI_01276 5.7e-304 xsa 3.2.1.55 GH51 G Alpha-L-arabinofuranosidase C-terminus
MNLHAPDI_01278 2.1e-177 etfA C Electron transfer flavoprotein
MNLHAPDI_01279 4.5e-135 etfB C Electron transfer flavoprotein
MNLHAPDI_01280 3.1e-136 fadB 4.2.1.17 I Belongs to the enoyl-CoA hydratase isomerase family
MNLHAPDI_01281 2.7e-100 fadR K Transcriptional regulator
MNLHAPDI_01282 0.0 lcfA 6.2.1.3 IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
MNLHAPDI_01283 7.3e-68 yshE S membrane
MNLHAPDI_01284 0.0 mutS2 L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
MNLHAPDI_01285 0.0 polX L COG1796 DNA polymerase IV (family X)
MNLHAPDI_01286 1.3e-85 cvpA S membrane protein, required for colicin V production
MNLHAPDI_01287 2.4e-40 zapA D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
MNLHAPDI_01288 4e-170 rnhC 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MNLHAPDI_01289 0.0 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
MNLHAPDI_01290 2.8e-196 pheS 6.1.1.20 J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MNLHAPDI_01291 3.1e-133 spoU 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MNLHAPDI_01292 2.6e-32 sspI S Belongs to the SspI family
MNLHAPDI_01293 4.4e-208 ysfB KT regulator
MNLHAPDI_01294 7.2e-264 glcD 1.1.3.15 C Glycolate oxidase subunit
MNLHAPDI_01295 5.6e-258 glcF C Glycolate oxidase
MNLHAPDI_01296 3.6e-38 ysfE 4.4.1.5 E lactoylglutathione lyase activity
MNLHAPDI_01298 0.0 cstA T Carbon starvation protein
MNLHAPDI_01299 1e-300 abfA 3.2.1.55 GH51 G alpha-L-arabinofuranosidase activity
MNLHAPDI_01300 3.8e-143 araQ G transport system permease
MNLHAPDI_01301 4.2e-167 araP G carbohydrate transport
MNLHAPDI_01302 5.3e-253 araN G carbohydrate transport
MNLHAPDI_01303 1.8e-220 egsA 1.1.1.261 I Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is probably used for the synthesis of phosphoglycerolipids in Gram-positive bacterial species
MNLHAPDI_01304 2e-146 araL 3.1.3.41 G Haloacid dehalogenase-like hydrolase
MNLHAPDI_01305 8.4e-133 araD 4.1.2.17, 4.2.1.109, 5.1.3.4 G COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases
MNLHAPDI_01306 0.0 araB 2.7.1.16 C Belongs to the ribulokinase family
MNLHAPDI_01307 1.9e-294 araA 5.3.1.4 G Catalyzes the conversion of L-arabinose to L-ribulose
MNLHAPDI_01308 2.1e-190 abnA 3.2.1.99 GH43 G Belongs to the glycosyl hydrolase 43 family
MNLHAPDI_01309 4.5e-205 ysdC G COG1363 Cellulase M and related proteins
MNLHAPDI_01310 9.2e-68 ysdB S Sigma-w pathway protein YsdB
MNLHAPDI_01311 7.5e-45 ysdA S Membrane
MNLHAPDI_01312 3.6e-58 rplT J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MNLHAPDI_01313 9e-27 rpmI J Belongs to the bacterial ribosomal protein bL35 family
MNLHAPDI_01314 3.3e-86 infC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MNLHAPDI_01316 2.4e-111 lrgB M Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses
MNLHAPDI_01317 2.2e-49 lrgA S Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses
MNLHAPDI_01318 6.3e-131 lytT T COG3279 Response regulator of the LytR AlgR family
MNLHAPDI_01319 0.0 lytS 2.7.13.3 T Histidine kinase
MNLHAPDI_01320 1.5e-149 ysaA S HAD-hyrolase-like
MNLHAPDI_01321 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MNLHAPDI_01322 3.8e-159 ytxC S YtxC-like family
MNLHAPDI_01323 4.9e-111 ytxB S SNARE associated Golgi protein
MNLHAPDI_01324 3e-173 dnaI L Primosomal protein DnaI
MNLHAPDI_01325 3.5e-266 dnaB L Membrane attachment protein
MNLHAPDI_01326 1.1e-80 nrdR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MNLHAPDI_01327 2e-67 speH 4.1.1.50 E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MNLHAPDI_01328 2.8e-193 gapB 1.2.1.12, 1.2.1.59 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
MNLHAPDI_01329 9.9e-67 ytcD K Transcriptional regulator
MNLHAPDI_01330 4.9e-205 ytbD EGP Major facilitator Superfamily
MNLHAPDI_01331 8.9e-161 ytbE S reductase
MNLHAPDI_01332 7.6e-98 coaE 2.7.1.24 F Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MNLHAPDI_01333 1.1e-107 ytaF P Probably functions as a manganese efflux pump
MNLHAPDI_01334 2e-157 fpg 3.2.2.23, 4.2.99.18 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
MNLHAPDI_01335 0.0 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MNLHAPDI_01336 0.0 phoR 2.7.13.3 T Signal transduction histidine kinase
MNLHAPDI_01337 2.2e-131 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MNLHAPDI_01338 1.1e-170 mdh 1.1.1.37 C Catalyzes the reversible oxidation of malate to oxaloacetate
MNLHAPDI_01339 1.8e-242 icd 1.1.1.42 C isocitrate
MNLHAPDI_01340 4.7e-210 citZ 2.3.3.1 C Belongs to the citrate synthase family
MNLHAPDI_01341 4.7e-71 yeaL S membrane
MNLHAPDI_01342 9.9e-192 ytvI S sporulation integral membrane protein YtvI
MNLHAPDI_01343 8.7e-63 fxsA S COG3030 Protein affecting phage T7 exclusion by the F plasmid
MNLHAPDI_01344 0.0 pyk 2.7.1.40, 2.7.7.4 G Belongs to the pyruvate kinase family
MNLHAPDI_01345 7.5e-180 pfkA 2.7.1.11 F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
MNLHAPDI_01346 8.1e-182 accA 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
MNLHAPDI_01347 3.5e-160 accD 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MNLHAPDI_01348 1.5e-225 ytsJ 1.1.1.38 C Malate dehydrogenase
MNLHAPDI_01349 0.0 dnaE 2.7.7.7 L DNA polymerase
MNLHAPDI_01350 3.2e-56 ytrH S Sporulation protein YtrH
MNLHAPDI_01351 8.2e-69 ytrI
MNLHAPDI_01352 9.2e-29
MNLHAPDI_01353 7.8e-182 nrnA 3.1.13.3, 3.1.3.7 S COG0618 Exopolyphosphatase-related proteins
MNLHAPDI_01354 2.4e-47 ytpI S YtpI-like protein
MNLHAPDI_01355 8e-241 ytoI K transcriptional regulator containing CBS domains
MNLHAPDI_01356 1.2e-158 ytnM S membrane transporter protein
MNLHAPDI_01357 4.9e-240 ytnL 3.5.1.47 E hydrolase activity
MNLHAPDI_01358 6.3e-128 ribF 2.7.1.26, 2.7.7.2 H Riboflavin kinase
MNLHAPDI_01359 1e-256 moxC C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MNLHAPDI_01360 2.9e-47 ytnI O COG0695 Glutaredoxin and related proteins
MNLHAPDI_01361 1.2e-185 ytmO C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MNLHAPDI_01362 1e-142 tcyN 3.6.3.21 E COG1126 ABC-type polar amino acid transport system, ATPase component
MNLHAPDI_01363 6.4e-120 tcyM U Binding-protein-dependent transport system inner membrane component
MNLHAPDI_01364 1.2e-121 tcyL P Binding-protein-dependent transport system inner membrane component
MNLHAPDI_01365 1.5e-149 tcyK M Bacterial periplasmic substrate-binding proteins
MNLHAPDI_01366 9.5e-152 tcyK ET Bacterial periplasmic substrate-binding proteins
MNLHAPDI_01367 1.5e-100 ytmI K Acetyltransferase (GNAT) domain
MNLHAPDI_01368 2.9e-173 ytlI K LysR substrate binding domain
MNLHAPDI_01369 1.7e-130 ytkL S Belongs to the UPF0173 family
MNLHAPDI_01370 1.1e-141 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MNLHAPDI_01372 1.2e-266 argH 4.3.2.1 E argininosuccinate lyase
MNLHAPDI_01373 2.3e-234 argG 6.3.4.5 E Belongs to the argininosuccinate synthase family. Type 1 subfamily
MNLHAPDI_01374 1.4e-87 moaB 2.7.7.75 H May be involved in the biosynthesis of molybdopterin
MNLHAPDI_01375 3.7e-221 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MNLHAPDI_01376 7e-165 ytxK 2.1.1.72 L DNA methylase
MNLHAPDI_01377 2.4e-89 tpx 1.11.1.15 O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
MNLHAPDI_01378 8.7e-70 ytfJ S Sporulation protein YtfJ
MNLHAPDI_01379 8.1e-115 ytfI S Protein of unknown function (DUF2953)
MNLHAPDI_01380 8.5e-87 yteJ S RDD family
MNLHAPDI_01381 1.1e-178 sppA OU signal peptide peptidase SppA
MNLHAPDI_01382 2.2e-148 nadK 2.7.1.23 G Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MNLHAPDI_01383 2.2e-311 ytcJ S amidohydrolase
MNLHAPDI_01384 2.5e-305 acsA 6.2.1.1, 6.2.1.2 I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases
MNLHAPDI_01385 2e-29 sspB S spore protein
MNLHAPDI_01386 3.5e-227 thiI 2.8.1.4 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MNLHAPDI_01387 3.3e-206 iscS2 2.8.1.7 E Cysteine desulfurase
MNLHAPDI_01388 4.9e-238 brnQ E Component of the transport system for branched-chain amino acids
MNLHAPDI_01389 4.1e-274 ezrA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
MNLHAPDI_01390 1.6e-154 hisK 3.1.3.15 E COG1387 Histidinol phosphatase and related hydrolases of the PHP family
MNLHAPDI_01391 3.4e-109 yttP K Transcriptional regulator
MNLHAPDI_01392 1.2e-88 ytsP 1.8.4.14 T GAF domain-containing protein
MNLHAPDI_01393 0.0 ytrP 2.7.7.65 T COG2199 FOG GGDEF domain
MNLHAPDI_01394 2.5e-109 rpsD J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MNLHAPDI_01396 3.6e-238 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MNLHAPDI_01397 0.0 acsA 6.2.1.1 I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases
MNLHAPDI_01398 3.6e-122 acuA K Part of the acuABC operon, which is possibly involved in the breakdown of acetoin and butanediol. Acts as an acetyltransferase inactivating acetyl-CoA synthetase AcsA via acetylation at a Lys residue
MNLHAPDI_01399 1.6e-117 acuB S Domain in cystathionine beta-synthase and other proteins.
MNLHAPDI_01400 5.4e-225 acuC BQ histone deacetylase
MNLHAPDI_01401 1.4e-125 motS N Flagellar motor protein
MNLHAPDI_01402 2.1e-146 motA N flagellar motor
MNLHAPDI_01403 1.7e-182 ccpA K catabolite control protein A
MNLHAPDI_01404 4.9e-196 aroF 2.5.1.54, 5.4.99.5 E Catalyzes the formation of 3-deoxy-D-aribino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate and the formation of prephenate from chorismate
MNLHAPDI_01405 4.4e-55 ytxJ O Protein of unknown function (DUF2847)
MNLHAPDI_01406 6.6e-17 ytxH S COG4980 Gas vesicle protein
MNLHAPDI_01407 1e-16 ytxG S protein containing a divergent version of the methyl-accepting chemotaxis-like domain
MNLHAPDI_01408 1.6e-254 mpl 6.3.2.4, 6.3.2.45, 6.3.2.8 M Belongs to the MurCDEF family
MNLHAPDI_01409 0.0 sftA D Belongs to the FtsK SpoIIIE SftA family
MNLHAPDI_01410 2.8e-108 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
MNLHAPDI_01411 9.8e-149 ytpQ S Belongs to the UPF0354 family
MNLHAPDI_01412 2.1e-57 ytpP 2.7.1.180, 5.3.4.1 CO Thioredoxin
MNLHAPDI_01413 5.9e-79 ytoQ S Nucleoside 2-deoxyribosyltransferase YtoQ
MNLHAPDI_01414 1.4e-206 pepA 3.4.11.7 G COG1363 Cellulase M and related proteins
MNLHAPDI_01415 1.1e-50 ytzB S small secreted protein
MNLHAPDI_01416 0.0 sfcA 1.1.1.38 C Malate dehydrogenase
MNLHAPDI_01417 8.4e-151 ytnP S COG0491 Zn-dependent hydrolases, including glyoxylases
MNLHAPDI_01418 1.4e-121 trmB 2.1.1.297, 2.1.1.33 J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
MNLHAPDI_01419 2e-45 ytzH S YtzH-like protein
MNLHAPDI_01420 6.1e-151 ytmP 2.7.1.89 M Phosphotransferase
MNLHAPDI_01421 0.0 pulA 3.2.1.41 CBM48,GH13 G Belongs to the glycosyl hydrolase 13 family
MNLHAPDI_01422 2.9e-181 ytlR 2.7.1.91 I Diacylglycerol kinase catalytic domain
MNLHAPDI_01423 1.3e-165 ytlQ
MNLHAPDI_01424 4.3e-103 ligT 3.1.4.58, 3.5.1.42 J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MNLHAPDI_01425 8.6e-173 ytkP 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
MNLHAPDI_01426 7.1e-272 pepV 3.5.1.18 E Dipeptidase
MNLHAPDI_01427 7.2e-226 pbuO S permease
MNLHAPDI_01428 3.9e-207 ythQ U Bacterial ABC transporter protein EcsB
MNLHAPDI_01429 4.3e-132 ythP V ABC transporter
MNLHAPDI_01430 2.4e-33 ytzE K COG1349 Transcriptional regulators of sugar metabolism
MNLHAPDI_01431 2.6e-132 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
MNLHAPDI_01432 7.2e-281 ytgP S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
MNLHAPDI_01433 8.2e-232 ytfP S HI0933-like protein
MNLHAPDI_01434 1.3e-282 opuD M Belongs to the BCCT transporter (TC 2.A.15) family
MNLHAPDI_01435 3.1e-26 yteV S Sporulation protein Cse60
MNLHAPDI_01436 4.5e-115 yteU S Integral membrane protein
MNLHAPDI_01437 2e-257 yteT S Oxidoreductase family, C-terminal alpha/beta domain
MNLHAPDI_01438 4.6e-73 yteS G transport
MNLHAPDI_01439 4.7e-226 yteR 3.2.1.172 GH105 G unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins
MNLHAPDI_01440 2e-172 lplB G COG4209 ABC-type polysaccharide transport system, permease component
MNLHAPDI_01441 0.0 ytdP K Transcriptional regulator
MNLHAPDI_01442 1.8e-289 ytcQ G COG1653 ABC-type sugar transport system, periplasmic component
MNLHAPDI_01443 1.3e-149 ytcP G COG0395 ABC-type sugar transport system, permease component
MNLHAPDI_01444 9e-136 udh 1.1.1.203, 1.1.1.388 GM NAD dependent epimerase/dehydratase family
MNLHAPDI_01445 1.8e-223 bioI 1.14.14.46 C Cytochrome P450
MNLHAPDI_01446 8.4e-190 bioB 2.8.1.6 H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MNLHAPDI_01447 3.8e-125 bioD 6.3.3.3 H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MNLHAPDI_01448 1.1e-217 bioF 2.3.1.29, 2.3.1.47, 6.2.1.14 H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide
MNLHAPDI_01449 1.1e-258 bioA 2.6.1.105, 2.6.1.62 H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor
MNLHAPDI_01450 5.2e-141 bioW 2.3.1.47, 6.2.1.14 H Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
MNLHAPDI_01451 5.4e-172 ytaP S Acetyl xylan esterase (AXE1)
MNLHAPDI_01452 4.3e-189 msmR K Transcriptional regulator
MNLHAPDI_01453 1.5e-244 msmE G Bacterial extracellular solute-binding protein
MNLHAPDI_01454 1.5e-166 amyD P ABC transporter
MNLHAPDI_01455 4.4e-144 amyC P ABC transporter (permease)
MNLHAPDI_01456 2.6e-252 melA 3.2.1.122, 3.2.1.22, 3.2.1.86 GH4,GT4 G Family 4 glycosyl hydrolase
MNLHAPDI_01457 8.1e-51 ytwF P Sulfurtransferase
MNLHAPDI_01458 0.0 leuS 6.1.1.4 J Belongs to the class-I aminoacyl-tRNA synthetase family
MNLHAPDI_01459 7.7e-55 ytvB S Protein of unknown function (DUF4257)
MNLHAPDI_01460 1.5e-141 pfyP T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)
MNLHAPDI_01461 1.5e-209 yttB EGP Major facilitator Superfamily
MNLHAPDI_01462 8.7e-43 yttA 2.7.13.3 S Pfam Transposase IS66
MNLHAPDI_01463 0.0 bceB V ABC transporter (permease)
MNLHAPDI_01464 1.1e-138 bceA V ABC transporter, ATP-binding protein
MNLHAPDI_01465 1.8e-184 T PhoQ Sensor
MNLHAPDI_01466 2.6e-129 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MNLHAPDI_01467 3e-232 ytrF V COG0577 ABC-type antimicrobial peptide transport system, permease component
MNLHAPDI_01468 3.1e-127 ytrE V ABC transporter, ATP-binding protein
MNLHAPDI_01469 5.9e-148
MNLHAPDI_01470 8.3e-166 P ABC-2 family transporter protein
MNLHAPDI_01471 4.2e-161 ytrB P abc transporter atp-binding protein
MNLHAPDI_01472 5.1e-66 ytrA K GntR family transcriptional regulator
MNLHAPDI_01474 6.7e-41 ytzC S Protein of unknown function (DUF2524)
MNLHAPDI_01475 8.1e-190 yhcC S Fe-S oxidoreductase
MNLHAPDI_01476 2.4e-104 ytqB J Putative rRNA methylase
MNLHAPDI_01477 2e-216 ytpB 4.2.3.130 S Tetraprenyl-beta-curcumene synthase
MNLHAPDI_01478 3.3e-149 ytpA 3.1.1.5 I Alpha beta hydrolase
MNLHAPDI_01479 2.1e-59 ytoA S COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MNLHAPDI_01480 1.4e-256 ytnA E COG1113 Gamma-aminobutyrate permease and related permeases
MNLHAPDI_01481 0.0 asnB 6.3.5.4 E Asparagine synthase
MNLHAPDI_01482 4.3e-225 metK 2.5.1.6 H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MNLHAPDI_01483 9.7e-310 pckA 4.1.1.49 C Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MNLHAPDI_01484 1.2e-38 ytmB S Protein of unknown function (DUF2584)
MNLHAPDI_01485 5.5e-149 ytmA E COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases
MNLHAPDI_01486 2.8e-188 ytlA P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components
MNLHAPDI_01487 1.4e-144 ytlC P ABC transporter
MNLHAPDI_01488 6.8e-142 ytlD P COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component
MNLHAPDI_01489 2.8e-87 ytkD 3.6.1.55 L Belongs to the Nudix hydrolase family
MNLHAPDI_01490 7.8e-62 ytkC S Bacteriophage holin family
MNLHAPDI_01491 2.1e-76 dps P Belongs to the Dps family
MNLHAPDI_01493 2e-71 ytkA S YtkA-like
MNLHAPDI_01494 4.8e-87 luxS 4.4.1.21 T Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
MNLHAPDI_01495 5.7e-103 ytiB 4.2.1.1 P Reversible hydration of carbon dioxide
MNLHAPDI_01496 3.6e-41 rpmE2 J Ribosomal protein L31
MNLHAPDI_01497 1.1e-248 cydA 1.10.3.14 C oxidase, subunit
MNLHAPDI_01498 1.1e-187 cydB 1.10.3.14 C COG1294 Cytochrome bd-type quinol oxidase, subunit 2
MNLHAPDI_01499 1.1e-24 S Domain of Unknown Function (DUF1540)
MNLHAPDI_01500 2.3e-151 troD P 'COG1108 ABC-type Mn2 Zn2 transport systems, permease components'
MNLHAPDI_01501 4.4e-231 mntC P COG1108 ABC-type Mn2 Zn2 transport systems, permease components
MNLHAPDI_01502 4.3e-138 mntB P 'COG1121 ABC-type Mn Zn transport systems, ATPase component'
MNLHAPDI_01503 1.8e-170 troA P Belongs to the bacterial solute-binding protein 9 family
MNLHAPDI_01504 5.4e-214 menC 4.2.1.113 H Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)
MNLHAPDI_01505 2.4e-278 menE 6.2.1.26 H Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily
MNLHAPDI_01506 4.2e-155 menB 4.1.3.36 H Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MNLHAPDI_01507 3.8e-156 menH 4.2.99.20 S Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC)
MNLHAPDI_01508 0.0 menD 2.2.1.9 H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MNLHAPDI_01509 8.5e-273 menF 5.4.4.2 HQ Isochorismate synthase
MNLHAPDI_01510 2.6e-132 dksA T COG1734 DnaK suppressor protein
MNLHAPDI_01511 1e-153 galU 2.7.7.9 M Nucleotidyl transferase
MNLHAPDI_01512 1.5e-244 ugd 1.1.1.22 M Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MNLHAPDI_01513 1.1e-180 ytcB 5.1.3.2 M NAD-dependent epimerase dehydratase
MNLHAPDI_01514 3.6e-235 ytcC M Glycosyltransferase Family 4
MNLHAPDI_01516 2.3e-206 cotS S Seems to be required for the assembly of the CotSA protein in spores
MNLHAPDI_01517 1.8e-217 cotSA M Glycosyl transferases group 1
MNLHAPDI_01518 1.8e-206 cotI S Spore coat protein
MNLHAPDI_01519 9.9e-77 tspO T membrane
MNLHAPDI_01520 0.0 glgP 2.4.1.1 GT35 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
MNLHAPDI_01521 4.3e-288 glgA 2.4.1.21 GT5 G Synthesizes alpha-1,4-glucan chains using ADP-glucose
MNLHAPDI_01522 2.9e-177 glgD 2.4.1.21, 2.7.7.27 GT5 G Glucose-1-phosphate adenylyltransferase, GlgD subunit
MNLHAPDI_01523 6.1e-197 glgC 2.7.7.27 G Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MNLHAPDI_01524 0.0 glgB 2.4.1.18, 3.2.1.141, 3.2.1.20 CBM48,GH13,GH31 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MNLHAPDI_01533 7.8e-08
MNLHAPDI_01534 1.3e-09
MNLHAPDI_01541 2e-08
MNLHAPDI_01546 3.4e-39 S COG NOG14552 non supervised orthologous group
MNLHAPDI_01547 4.3e-90 thiT S Thiamine transporter protein (Thia_YuaJ)
MNLHAPDI_01548 3.4e-94 M1-753 M FR47-like protein
MNLHAPDI_01549 4.1e-188 yuaG 3.4.21.72 S protein conserved in bacteria
MNLHAPDI_01550 1.4e-77 yuaF OU Membrane protein implicated in regulation of membrane protease activity
MNLHAPDI_01551 3.9e-84 yuaE S DinB superfamily
MNLHAPDI_01552 3.9e-107 yuaD
MNLHAPDI_01553 2.9e-229 gbsB 1.1.1.1 C alcohol dehydrogenase
MNLHAPDI_01554 8e-282 gbsA 1.2.1.8 C Belongs to the aldehyde dehydrogenase family
MNLHAPDI_01555 2.7e-94 yuaC K Belongs to the GbsR family
MNLHAPDI_01556 2.2e-91 yuaB
MNLHAPDI_01557 2.7e-120 ktrA P COG0569 K transport systems, NAD-binding component
MNLHAPDI_01558 1.6e-236 ktrB P Potassium
MNLHAPDI_01559 1e-38 yiaA S yiaA/B two helix domain
MNLHAPDI_01560 6.4e-153 NU Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
MNLHAPDI_01561 4.9e-274 yubD P Major Facilitator Superfamily
MNLHAPDI_01562 6.4e-87 cdoA 1.13.11.20 S Cysteine dioxygenase type I
MNLHAPDI_01564 2.7e-133 uppP 3.6.1.27 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
MNLHAPDI_01565 1.3e-194 yubA S transporter activity
MNLHAPDI_01566 5.7e-183 ygjR S Oxidoreductase
MNLHAPDI_01567 3.7e-251 rhaA 2.7.1.5, 5.3.1.14 G Belongs to the rhamnose isomerase family
MNLHAPDI_01568 7.2e-55 rhaM 5.1.3.32 G Involved in the anomeric conversion of L-rhamnose
MNLHAPDI_01569 2.9e-276 rhaB 2.7.1.12, 2.7.1.17, 2.7.1.5, 5.3.1.14 G Involved in the catabolism of L-rhamnose (6-deoxy-L- mannose). Catalyzes the transfer of the gamma-phosphate group from ATP to the 1-hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate
MNLHAPDI_01570 3.8e-134 fucR K COG1349 Transcriptional regulators of sugar metabolism
MNLHAPDI_01571 0.0 rhaD 1.1.1.1, 4.1.2.19 IQ Class II Aldolase and Adducin N-terminal domain
MNLHAPDI_01572 3.3e-238 mcpA NT chemotaxis protein
MNLHAPDI_01573 8.5e-295 mcpA NT chemotaxis protein
MNLHAPDI_01574 6.9e-220 mcpA NT chemotaxis protein
MNLHAPDI_01575 9.3e-225 mcpA NT chemotaxis protein
MNLHAPDI_01576 9.9e-140 tgl 2.3.2.13 S protein-glutamine gamma-glutamyltransferase activity
MNLHAPDI_01577 2.3e-35
MNLHAPDI_01578 2.1e-72 yugU S Uncharacterised protein family UPF0047
MNLHAPDI_01579 0.0 yugT 3.2.1.10, 3.2.1.20 GH13,GH31 G COG0366 Glycosidases
MNLHAPDI_01580 2.9e-235 yugS S COG1253 Hemolysins and related proteins containing CBS domains
MNLHAPDI_01581 1.4e-116 yugP S Zn-dependent protease
MNLHAPDI_01582 3.7e-36
MNLHAPDI_01583 1.1e-53 mstX S Membrane-integrating protein Mistic
MNLHAPDI_01584 2.2e-182 yugO P COG1226 Kef-type K transport systems
MNLHAPDI_01585 1.3e-72 yugN S YugN-like family
MNLHAPDI_01587 4.2e-261 pgi 5.3.1.9 G Belongs to the GPI family
MNLHAPDI_01588 2.8e-229 yugK C Dehydrogenase
MNLHAPDI_01589 8.9e-228 yugJ C oxidoreductases, Fe-dependent alcohol dehydrogenase family
MNLHAPDI_01590 1.1e-34 yuzA S Domain of unknown function (DUF378)
MNLHAPDI_01591 8.9e-63 yugI 5.3.1.9 J RNA binding protein (contains ribosomal protein S1 domain)
MNLHAPDI_01592 2.1e-199 yugH 2.6.1.1 E Aminotransferase
MNLHAPDI_01593 1.6e-85 alaR K Transcriptional regulator
MNLHAPDI_01594 1e-156 yugF I Hydrolase
MNLHAPDI_01595 1.1e-40 yugE S Domain of unknown function (DUF1871)
MNLHAPDI_01596 1.8e-228 patB 4.4.1.8 E COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
MNLHAPDI_01597 4.6e-233 T PhoQ Sensor
MNLHAPDI_01598 2e-70 kapB G Kinase associated protein B
MNLHAPDI_01599 1.9e-115 kapD L the KinA pathway to sporulation
MNLHAPDI_01601 3.5e-186 yuxJ EGP Major facilitator Superfamily
MNLHAPDI_01602 0.0 mrcB 2.4.1.129, 3.4.16.4 GT51 M Penicillin-binding Protein
MNLHAPDI_01603 6.3e-75 yuxK S protein conserved in bacteria
MNLHAPDI_01604 6.3e-78 yufK S Family of unknown function (DUF5366)
MNLHAPDI_01605 9.9e-294 dcuS 2.7.13.3 T Signal transduction histidine kinase regulating citrate malate metabolism
MNLHAPDI_01606 2.3e-125 dcuR T COG4565 Response regulator of citrate malate metabolism
MNLHAPDI_01607 3.4e-197 tcsA S ABC-type transport system, periplasmic component surface lipoprotein
MNLHAPDI_01608 1.1e-273 xylG 3.6.3.17 S ABC transporter, ATP-binding protein
MNLHAPDI_01609 6.5e-185 yufP S Belongs to the binding-protein-dependent transport system permease family
MNLHAPDI_01610 4.5e-169 yufQ S Belongs to the binding-protein-dependent transport system permease family
MNLHAPDI_01611 1.3e-233 maeN C COG3493 Na citrate symporter
MNLHAPDI_01612 1.9e-14
MNLHAPDI_01613 0.0 phaA 1.6.5.3 CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit
MNLHAPDI_01614 5.4e-69 mrpB P Subunit B of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
MNLHAPDI_01615 1.5e-50 phaC 1.6.5.3 P Subunit C of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
MNLHAPDI_01616 4.9e-263 mrpD CP Subunit D of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
MNLHAPDI_01617 1.1e-78 mrpE P Subunit E of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
MNLHAPDI_01618 7.2e-38 phaF P Subunit F of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
MNLHAPDI_01619 5.2e-60 phaG P COG1320 Multisubunit Na H antiporter, MnhG subunit
MNLHAPDI_01620 2.3e-63 ydiI Q protein, possibly involved in aromatic compounds catabolism
MNLHAPDI_01621 5.1e-116 comA K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MNLHAPDI_01622 0.0 comP 2.7.13.3 T Histidine kinase
MNLHAPDI_01624 1.5e-127 comQ H Belongs to the FPP GGPP synthase family
MNLHAPDI_01627 3.2e-22 yuzC
MNLHAPDI_01628 1.8e-231 yuxH 3.1.4.52 T signal transduction protein containing EAL and modified HD-GYP domains
MNLHAPDI_01629 3.6e-266 pncB 6.3.4.21 H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MNLHAPDI_01630 1.5e-103 pncA Q COG1335 Amidases related to nicotinamidase
MNLHAPDI_01631 7.9e-67 yueI S Protein of unknown function (DUF1694)
MNLHAPDI_01632 2.8e-38 yueH S YueH-like protein
MNLHAPDI_01633 2.1e-32 yueG S Spore germination protein gerPA/gerPF
MNLHAPDI_01634 1.9e-190 yueF S transporter activity
MNLHAPDI_01635 6.1e-72 S Protein of unknown function (DUF2283)
MNLHAPDI_01636 2.9e-24 S Protein of unknown function (DUF2642)
MNLHAPDI_01637 4.8e-96 yueE S phosphohydrolase
MNLHAPDI_01638 4.4e-132 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MNLHAPDI_01639 6.6e-65 yueC S Family of unknown function (DUF5383)
MNLHAPDI_01640 0.0 esaA S type VII secretion protein EsaA
MNLHAPDI_01641 0.0 essC D COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins
MNLHAPDI_01642 2.3e-211 essB S WXG100 protein secretion system (Wss), protein YukC
MNLHAPDI_01643 7.7e-41 yukD S WXG100 protein secretion system (Wss), protein YukD
MNLHAPDI_01644 2.8e-45 esxA S Belongs to the WXG100 family
MNLHAPDI_01645 6.5e-229 yukF QT Transcriptional regulator
MNLHAPDI_01646 1.2e-205 ald 1.4.1.1 E Belongs to the AlaDH PNT family
MNLHAPDI_01647 1.1e-132 yukJ S Uncharacterized conserved protein (DUF2278)
MNLHAPDI_01648 3.8e-36 mbtH S MbtH-like protein
MNLHAPDI_01649 0.0 dhbF Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MNLHAPDI_01650 8.9e-178 entB 3.3.2.1, 6.3.2.14 Q Isochorismatase family
MNLHAPDI_01651 0.0 entE 2.7.7.58, 6.3.2.14 Q 2,3-dihydroxybenzoate-AMP ligase
MNLHAPDI_01652 2.3e-226 entC 5.4.4.2 HQ Isochorismate synthase
MNLHAPDI_01653 3.6e-140 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
MNLHAPDI_01654 9.6e-166 besA S Putative esterase
MNLHAPDI_01655 5.8e-122 yuiH S Oxidoreductase molybdopterin binding domain
MNLHAPDI_01656 1.1e-93 bioY S Biotin biosynthesis protein
MNLHAPDI_01657 3.9e-211 yuiF S antiporter
MNLHAPDI_01658 3.4e-280 pepA 3.4.11.1, 3.4.11.5 E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MNLHAPDI_01659 1.2e-77 yuiD S protein conserved in bacteria
MNLHAPDI_01660 9.5e-118 yuiC S protein conserved in bacteria
MNLHAPDI_01661 8.4e-27 yuiB S Putative membrane protein
MNLHAPDI_01662 2.5e-236 yumB 1.6.99.3 C NADH dehydrogenase
MNLHAPDI_01663 3.5e-188 yumC 1.18.1.2, 1.19.1.1 C reductase
MNLHAPDI_01665 6e-185 guaC 1.1.1.205, 1.7.1.7 F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
MNLHAPDI_01666 1e-116 paiB K Putative FMN-binding domain
MNLHAPDI_01667 1.8e-71 paiA 2.3.1.57 K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
MNLHAPDI_01668 3.7e-63 erpA S Belongs to the HesB IscA family
MNLHAPDI_01669 2.2e-162 dapF 5.1.1.7 E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MNLHAPDI_01670 5.3e-199 yutK F Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MNLHAPDI_01671 3.2e-39 yuzB S Belongs to the UPF0349 family
MNLHAPDI_01672 1.2e-199 yutJ 1.6.99.3 C NADH dehydrogenase
MNLHAPDI_01673 3.5e-57 yuzD S protein conserved in bacteria
MNLHAPDI_01674 1.2e-35 yutI O COG0694 Thioredoxin-like proteins and domains
MNLHAPDI_01675 0.0 yuxL 3.4.14.5, 3.4.19.1 EU peptidase
MNLHAPDI_01676 8.6e-173 thrB 2.7.1.39 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
MNLHAPDI_01677 2.3e-198 thrC 4.2.3.1 E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MNLHAPDI_01678 2.7e-241 hom 1.1.1.3 E homoserine dehydrogenase
MNLHAPDI_01679 2e-199 yutH S Spore coat protein
MNLHAPDI_01680 2.5e-77 pgpA 3.1.3.27 I COG1267 Phosphatidylglycerophosphatase A and related proteins
MNLHAPDI_01681 6.5e-142 nagD 2.7.1.25, 3.1.3.41 G Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
MNLHAPDI_01682 1e-75 yutE S Protein of unknown function DUF86
MNLHAPDI_01683 9.7e-48 yutD S protein conserved in bacteria
MNLHAPDI_01684 4.9e-111 yutC S Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
MNLHAPDI_01685 1e-167 lipA 2.8.1.8 H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MNLHAPDI_01686 4.5e-196 lytH M Peptidase, M23
MNLHAPDI_01687 8.4e-134 yunB S Sporulation protein YunB (Spo_YunB)
MNLHAPDI_01688 4.8e-48 yunC S Domain of unknown function (DUF1805)
MNLHAPDI_01689 5.8e-266 yunD 3.1.3.5 F Belongs to the 5'-nucleotidase family
MNLHAPDI_01690 2e-141 yunE S membrane transporter protein
MNLHAPDI_01691 4.3e-171 yunF S Protein of unknown function DUF72
MNLHAPDI_01692 3e-62 yunG
MNLHAPDI_01693 1e-259 allB 3.5.2.5 F Catalyzes the conversion of allantoin (5- ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring
MNLHAPDI_01694 1.2e-302 pucR QT COG2508 Regulator of polyketide synthase expression
MNLHAPDI_01695 2.1e-236 pbuX F Permease family
MNLHAPDI_01696 1.3e-222 pbuX F xanthine
MNLHAPDI_01697 7.3e-283 uraD 1.7.3.3, 3.5.1.41, 4.1.1.97 Q Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin
MNLHAPDI_01698 2.7e-55 uraH 3.5.2.17, 4.1.1.97 S Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily
MNLHAPDI_01699 1.8e-95 1.17.1.4, 1.2.5.3, 1.3.99.16 C COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs
MNLHAPDI_01700 0.0 xdhA 1.17.1.4 C COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs
MNLHAPDI_01701 3.4e-152 ygfM 1.17.1.4, 1.2.5.3 C COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM CutM homologs
MNLHAPDI_01702 3.6e-111 pucB 1.1.1.328, 1.17.1.4, 2.7.7.76 S MobA-like NTP transferase domain
MNLHAPDI_01703 1.7e-190 pucA 1.17.1.4 O COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MNLHAPDI_01705 1.9e-239 pucG 2.6.1.112, 2.6.1.44, 2.6.1.45, 2.6.1.51 E COG0075 Serine-pyruvate aminotransferase archaeal aspartate aminotransferase
MNLHAPDI_01706 1.6e-238 pucF 3.5.1.6, 3.5.1.87, 3.5.3.9 E COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases
MNLHAPDI_01707 2.4e-169 bsn L Ribonuclease
MNLHAPDI_01708 1.2e-205 msmX P Belongs to the ABC transporter superfamily
MNLHAPDI_01709 1.1e-135 yurK K UTRA
MNLHAPDI_01710 1.5e-163 yurL 2.7.1.218 G pfkB family carbohydrate kinase
MNLHAPDI_01711 7.3e-169 yurM P COG0395 ABC-type sugar transport system, permease component
MNLHAPDI_01712 5.3e-156 yurN G Binding-protein-dependent transport system inner membrane component
MNLHAPDI_01713 1.3e-240 yurO G COG1653 ABC-type sugar transport system, periplasmic component
MNLHAPDI_01714 1.8e-184 frlB M Catalyzes the conversion of a range of fructosamine 6- phosphates to glucose 6-phosphate and a free amino acid
MNLHAPDI_01715 2.8e-66 yurQ 2.7.7.7 L COG0322 Nuclease subunit of the excinuclease complex
MNLHAPDI_01716 1.8e-209 yurR 1.4.5.1 E COG0665 Glycine D-amino acid oxidases (deaminating)
MNLHAPDI_01718 1e-41
MNLHAPDI_01719 7.6e-67 yurT E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
MNLHAPDI_01720 3.5e-271 sufB O FeS cluster assembly
MNLHAPDI_01721 1.4e-77 nifU C COG0822 NifU homolog involved in Fe-S cluster formation
MNLHAPDI_01722 9.4e-236 sufS 2.8.1.7, 4.4.1.16 E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MNLHAPDI_01723 1.4e-245 sufD O assembly protein SufD
MNLHAPDI_01724 2.3e-142 sufC O COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component
MNLHAPDI_01725 1.1e-62 yurZ 2.3.1.12, 4.1.1.44 S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MNLHAPDI_01726 1.9e-147 metQ P Belongs to the NlpA lipoprotein family
MNLHAPDI_01727 1.4e-95 metI P COG2011 ABC-type metal ion transport system, permease component
MNLHAPDI_01728 4.8e-185 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MNLHAPDI_01729 2.4e-56 yusD S SCP-2 sterol transfer family
MNLHAPDI_01730 5.6e-55 traF CO Thioredoxin
MNLHAPDI_01731 3.3e-74 rnmV 3.1.26.8 L COG1658 Small primase-like proteins (Toprim domain)
MNLHAPDI_01732 1.1e-39 yusG S Protein of unknown function (DUF2553)
MNLHAPDI_01733 9.3e-65 gcvH E Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate
MNLHAPDI_01734 2.8e-63 arsC 1.20.4.1 P Belongs to the ArsC family
MNLHAPDI_01735 0.0 fadE 1.3.8.1 I acyl-CoA dehydrogenase
MNLHAPDI_01736 1.4e-217 fadA 2.3.1.16 I Belongs to the thiolase family
MNLHAPDI_01737 0.0 fadB 1.1.1.35, 4.2.1.17, 5.1.2.3 I 3-hydroxyacyl-CoA dehydrogenase
MNLHAPDI_01738 4.7e-09 S YuzL-like protein
MNLHAPDI_01739 2.2e-165 fadM E Proline dehydrogenase
MNLHAPDI_01740 5.1e-40
MNLHAPDI_01741 3.2e-53 yusN M Coat F domain
MNLHAPDI_01742 5.4e-75 yusO K Iron dependent repressor, N-terminal DNA binding domain
MNLHAPDI_01743 3.8e-293 yusP P Major facilitator superfamily
MNLHAPDI_01744 8.4e-66 yusQ S Tautomerase enzyme
MNLHAPDI_01745 2.5e-62 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
MNLHAPDI_01746 2.5e-50 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
MNLHAPDI_01747 8.8e-159 yusT K LysR substrate binding domain
MNLHAPDI_01748 3.8e-47 yusU S Protein of unknown function (DUF2573)
MNLHAPDI_01749 1e-153 yusV 3.6.3.34 HP ABC transporter
MNLHAPDI_01750 5.6e-66 S YusW-like protein
MNLHAPDI_01751 3.2e-301 pepF2 E COG1164 Oligoendopeptidase F
MNLHAPDI_01752 4.7e-154 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
MNLHAPDI_01753 1.2e-79 dps P Ferritin-like domain
MNLHAPDI_01754 9.6e-237 htrA 3.4.21.107 O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MNLHAPDI_01755 3.4e-126 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MNLHAPDI_01756 4.3e-250 cssS 2.7.13.3 T PhoQ Sensor
MNLHAPDI_01757 4.3e-158 yuxN K Transcriptional regulator
MNLHAPDI_01758 2.5e-261 fumC 1.1.1.38, 4.2.1.2 C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
MNLHAPDI_01759 2.3e-24 S Protein of unknown function (DUF3970)
MNLHAPDI_01760 3.7e-247 gerAA EG Spore germination protein
MNLHAPDI_01761 9.1e-198 gerAB E Spore germination protein
MNLHAPDI_01762 6e-189 gerAC S Spore germination B3/ GerAC like, C-terminal
MNLHAPDI_01763 1.3e-108 vraR KT COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MNLHAPDI_01764 3.5e-186 vraS 2.7.13.3 T Histidine kinase
MNLHAPDI_01765 9.5e-127 yvqF S Cell wall-active antibiotics response 4TMS YvqF
MNLHAPDI_01766 9.3e-129 liaG S Putative adhesin
MNLHAPDI_01767 2.5e-105 liaH KT COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription
MNLHAPDI_01768 5.6e-62 liaI S membrane
MNLHAPDI_01769 4.8e-227 yvqJ EGP Major facilitator Superfamily
MNLHAPDI_01770 6.5e-102 yvqK 2.5.1.17 S Adenosyltransferase
MNLHAPDI_01771 5.2e-248 yvrA 3.6.3.34 HP COG1120 ABC-type cobalamin Fe3 -siderophores transport systems, ATPase components
MNLHAPDI_01772 2.5e-184 btuC P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MNLHAPDI_01773 1.3e-168 yvrC P COG0614 ABC-type Fe3 -hydroxamate transport system, periplasmic component
MNLHAPDI_01774 1.4e-139 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
MNLHAPDI_01775 1.5e-171 yvrE G SMP-30/Gluconolaconase/LRE-like region
MNLHAPDI_01776 0.0 T PhoQ Sensor
MNLHAPDI_01777 3.2e-131 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MNLHAPDI_01778 3.6e-22
MNLHAPDI_01779 1.6e-97 yvrI K RNA polymerase
MNLHAPDI_01780 2.4e-19 S YvrJ protein family
MNLHAPDI_01781 7.3e-230 oxdC 4.1.1.2 G Oxalate decarboxylase
MNLHAPDI_01782 1.3e-64 yvrL S Regulatory protein YrvL
MNLHAPDI_01783 4.1e-210 yvrN V COG0577 ABC-type antimicrobial peptide transport system, permease component
MNLHAPDI_01784 1.6e-123 macB V ABC transporter, ATP-binding protein
MNLHAPDI_01785 7.6e-174 M Efflux transporter rnd family, mfp subunit
MNLHAPDI_01787 4.9e-148 fhuC 3.6.3.34 HP ABC transporter
MNLHAPDI_01788 6.9e-176 fhuG P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MNLHAPDI_01789 4.6e-183 fhuB P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MNLHAPDI_01790 1.2e-177 fhuD P ABC transporter
MNLHAPDI_01791 4.9e-236 yvsH E Arginine ornithine antiporter
MNLHAPDI_01792 6.5e-16 S Small spore protein J (Spore_SspJ)
MNLHAPDI_01793 1e-84 yvsG S LexA-binding, inner membrane-associated putative hydrolase
MNLHAPDI_01794 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
MNLHAPDI_01795 2e-166 yvgK P COG1910 Periplasmic molybdate-binding protein domain
MNLHAPDI_01796 1.6e-135 modA P COG0725 ABC-type molybdate transport system, periplasmic component
MNLHAPDI_01797 1.7e-117 modB P COG4149 ABC-type molybdate transport system, permease component
MNLHAPDI_01798 1.1e-155 yvgN S reductase
MNLHAPDI_01799 5.4e-86 yvgO
MNLHAPDI_01800 0.0 yjcE P COG0025 NhaP-type Na H and K H antiporters
MNLHAPDI_01801 0.0 cysI 1.7.7.1, 1.8.1.2, 1.8.7.1 P Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate
MNLHAPDI_01802 0.0 cysJ 1.8.1.2 P Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MNLHAPDI_01803 0.0 helD 3.6.4.12 L DNA helicase
MNLHAPDI_01804 4.1e-107 yvgT S membrane
MNLHAPDI_01805 2.2e-72 bdbC O Required for disulfide bond formation in some proteins
MNLHAPDI_01806 1.6e-104 bdbD O Thioredoxin
MNLHAPDI_01807 0.0 cadA 3.6.3.3, 3.6.3.5 P COG2217 Cation transport ATPase
MNLHAPDI_01808 0.0 copA 3.6.3.54 P P-type ATPase
MNLHAPDI_01809 1.5e-29 copZ P Copper resistance protein CopZ
MNLHAPDI_01810 2.2e-48 csoR S transcriptional
MNLHAPDI_01811 5.6e-197 yvaA 1.1.1.371 S Oxidoreductase
MNLHAPDI_01812 2.4e-118 azoR I Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MNLHAPDI_01813 5.3e-287 yvaC S Fusaric acid resistance protein-like
MNLHAPDI_01814 4.8e-23 yvaC S Fusaric acid resistance protein-like
MNLHAPDI_01815 5.7e-73 yvaD S Family of unknown function (DUF5360)
MNLHAPDI_01816 2.4e-54 yvaE P Small Multidrug Resistance protein
MNLHAPDI_01817 3.9e-99 K Bacterial regulatory proteins, tetR family
MNLHAPDI_01818 9.1e-131 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
MNLHAPDI_01820 1.6e-82 smpB O Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MNLHAPDI_01821 0.0 rnr K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
MNLHAPDI_01822 5.6e-143 est 3.1.1.1 S Carboxylesterase
MNLHAPDI_01823 2.4e-23 secG U Preprotein translocase subunit SecG
MNLHAPDI_01824 2.2e-150 yvaM S Serine aminopeptidase, S33
MNLHAPDI_01825 7.5e-36 yvzC K Transcriptional
MNLHAPDI_01826 4e-69 K transcriptional
MNLHAPDI_01827 5.2e-69 yvaO K Cro/C1-type HTH DNA-binding domain
MNLHAPDI_01828 2.2e-54 yodB K transcriptional
MNLHAPDI_01829 5.3e-213 NT chemotaxis protein
MNLHAPDI_01830 8.1e-112 opuCD P COG1174 ABC-type proline glycine betaine transport systems, permease component
MNLHAPDI_01831 1.1e-172 opuCC M COG1732 Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
MNLHAPDI_01832 2.5e-110 opuCB P COG1174 ABC-type proline glycine betaine transport systems, permease component
MNLHAPDI_01833 3e-212 opuCA 3.6.3.32 E COG1125 ABC-type proline glycine betaine transport systems, ATPase components
MNLHAPDI_01834 8.7e-61 yvbF K Belongs to the GbsR family
MNLHAPDI_01835 5.1e-12 S Sporulation delaying protein SdpA
MNLHAPDI_01836 1.4e-170
MNLHAPDI_01837 4.4e-08
MNLHAPDI_01838 3.1e-94 sdpI S Immunity protein that provides protection for the cell against the toxic effects of SDP, its own SdpC-derived killing factor, and that functions as a receptor signal transduction protein as well. Once SDP accumulates in the extracellular milieu, SdpI binds to SDP, causing sequestration of SdpR at the bacterial membrane
MNLHAPDI_01839 4.5e-45 sdpR K transcriptional
MNLHAPDI_01840 8.7e-114 opuCD P COG1174 ABC-type proline glycine betaine transport systems, permease component
MNLHAPDI_01841 2.5e-172 opuCC M COG1732 Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
MNLHAPDI_01842 4.5e-112 opuCB P COG1174 ABC-type proline glycine betaine transport systems, permease component
MNLHAPDI_01843 8.8e-212 opuCA 3.6.3.32 E COG1125 ABC-type proline glycine betaine transport systems, ATPase components
MNLHAPDI_01844 1.4e-98 yvbF K Belongs to the GbsR family
MNLHAPDI_01845 6.4e-103 yvbG U UPF0056 membrane protein
MNLHAPDI_01846 5.6e-112 yvbH S YvbH-like oligomerisation region
MNLHAPDI_01847 4.2e-124 exoY M Membrane
MNLHAPDI_01848 0.0 tcaA S response to antibiotic
MNLHAPDI_01849 7.7e-82 yvbK 3.1.3.25 K acetyltransferase
MNLHAPDI_01850 8.4e-243 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
MNLHAPDI_01851 1.3e-298 gpmI 5.4.2.12 G Catalyzes the interconversion of 2-phosphoglycerate and
MNLHAPDI_01852 4.3e-138 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
MNLHAPDI_01853 1e-218 pgk 2.7.2.3, 5.3.1.1 F Belongs to the phosphoglycerate kinase family
MNLHAPDI_01854 6.2e-185 gapA 1.2.1.12 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
MNLHAPDI_01855 6.3e-185 cggR K COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain
MNLHAPDI_01856 1.6e-252 araE EGP Major facilitator Superfamily
MNLHAPDI_01857 5.5e-203 araR K transcriptional
MNLHAPDI_01858 1.5e-191 yvbT C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MNLHAPDI_01859 3.9e-159 yvbU K Transcriptional regulator
MNLHAPDI_01860 8.5e-157 yvbV EG EamA-like transporter family
MNLHAPDI_01861 6.2e-241 yvbW E COG1113 Gamma-aminobutyrate permease and related permeases
MNLHAPDI_01862 1.8e-195 yvbX S Glycosyl hydrolase
MNLHAPDI_01863 2e-132 lutC S Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source
MNLHAPDI_01864 1e-273 lutB C Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source. Has probably a role as an electron transporter during oxidation of L-lactate
MNLHAPDI_01865 5.9e-137 lutA C Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source
MNLHAPDI_01866 1e-105 desR T COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MNLHAPDI_01867 1.3e-194 desK 2.7.13.3 T Histidine kinase
MNLHAPDI_01868 4e-133 yvfS V COG0842 ABC-type multidrug transport system, permease component
MNLHAPDI_01869 4.4e-158 yvfR V COG1131 ABC-type multidrug transport system, ATPase component
MNLHAPDI_01870 4.4e-157 rsbQ S Alpha/beta hydrolase family
MNLHAPDI_01871 2.5e-196 rsbU 3.1.3.3 T response regulator
MNLHAPDI_01872 1e-248 galA 3.2.1.89 G arabinogalactan
MNLHAPDI_01873 0.0 lacA 3.2.1.23 G beta-galactosidase
MNLHAPDI_01874 7.2e-150 ganQ P transport
MNLHAPDI_01875 1.1e-231 malC P COG1175 ABC-type sugar transport systems, permease components
MNLHAPDI_01876 5.5e-231 cycB G COG2182 Maltose-binding periplasmic proteins domains
MNLHAPDI_01877 1.8e-184 lacR K Transcriptional regulator
MNLHAPDI_01878 1e-112 yvfI K COG2186 Transcriptional regulators
MNLHAPDI_01879 1.4e-309 yvfH C L-lactate permease
MNLHAPDI_01880 6.5e-243 rpoN K COG1508 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog
MNLHAPDI_01881 1e-31 yvfG S YvfG protein
MNLHAPDI_01882 5.8e-188 yvfF GM Exopolysaccharide biosynthesis protein
MNLHAPDI_01883 1.2e-224 epsN 2.6.1.102 E Belongs to the DegT DnrJ EryC1 family
MNLHAPDI_01884 2.2e-58 epsM GM COG0110 Acetyltransferase (isoleucine patch superfamily)
MNLHAPDI_01885 2.6e-109 epsL M COG2148 Sugar transferases involved in lipopolysaccharide synthesis
MNLHAPDI_01886 3.4e-259 pglK S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
MNLHAPDI_01887 1.9e-197 epsJ GT2 S COG0463 Glycosyltransferases involved in cell wall biogenesis
MNLHAPDI_01888 3.6e-207 epsI GM pyruvyl transferase
MNLHAPDI_01889 1.4e-195 epsH GT2 S Glycosyltransferase like family 2
MNLHAPDI_01890 3.1e-206 epsG S EpsG family
MNLHAPDI_01891 9.3e-217 epsF GT4 M Glycosyl transferases group 1
MNLHAPDI_01892 1.2e-157 epsE GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
MNLHAPDI_01893 8e-221 epsD GT4 M Glycosyl transferase 4-like
MNLHAPDI_01894 0.0 pglF 4.2.1.115, 4.2.1.135, 4.2.1.46 GM Polysaccharide biosynthesis protein
MNLHAPDI_01895 1e-114 epsB 2.7.10.2 D COG0489 ATPases involved in chromosome partitioning
MNLHAPDI_01896 4e-122 ywqC M biosynthesis protein
MNLHAPDI_01897 5.7e-77 slr K transcriptional
MNLHAPDI_01898 4.8e-287 pnbA CE10 I Belongs to the type-B carboxylesterase lipase family
MNLHAPDI_01900 1.7e-92 padC Q Phenolic acid decarboxylase
MNLHAPDI_01901 3.8e-73 MA20_18690 S Protein of unknown function (DUF3237)
MNLHAPDI_01902 1.1e-124 racX 5.1.1.13 M Belongs to the aspartate glutamate racemases family
MNLHAPDI_01903 3.2e-261 pbpE V Beta-lactamase
MNLHAPDI_01904 1.2e-274 sacB 2.4.1.10 GH68 M levansucrase activity
MNLHAPDI_01905 0.0 levB 3.2.1.26, 3.2.1.64, 3.2.1.65, 3.2.1.80 GH32 G Belongs to the glycosyl hydrolase 32 family
MNLHAPDI_01906 1.8e-295 yveA E amino acid
MNLHAPDI_01907 2.6e-106 yvdT K Transcriptional regulator
MNLHAPDI_01908 6.7e-51 ykkC P Small Multidrug Resistance protein
MNLHAPDI_01909 4.1e-50 sugE P Small Multidrug Resistance protein
MNLHAPDI_01910 2.2e-93 yvdQ S Protein of unknown function (DUF3231)
MNLHAPDI_01911 8.4e-270 ygaK C COG0277 FAD FMN-containing dehydrogenases
MNLHAPDI_01912 1.5e-183 S Patatin-like phospholipase
MNLHAPDI_01914 1.2e-103 clpP 3.4.21.92 OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
MNLHAPDI_01915 1.3e-122 pgmB 2.4.1.64, 3.1.3.12, 3.2.1.28, 5.4.2.6 GH37,GH65 S Haloacid dehalogenase-like hydrolase
MNLHAPDI_01916 0.0 malL 3.2.1.10 GH13 G COG0366 Glycosidases
MNLHAPDI_01917 0.0 yvdK 2.4.1.8 GH65 G Glycoside hydrolase, family 65
MNLHAPDI_01918 2.9e-154 malA S Protein of unknown function (DUF1189)
MNLHAPDI_01919 1.5e-147 malD P transport
MNLHAPDI_01920 1e-243 malC P COG1175 ABC-type sugar transport systems, permease components
MNLHAPDI_01921 2e-233 mdxE G COG2182 Maltose-binding periplasmic proteins domains
MNLHAPDI_01922 0.0 nplT 3.2.1.133, 3.2.1.135, 3.2.1.54 GH13 G Alpha amylase, N-terminal ig-like domain
MNLHAPDI_01923 3.6e-174 yvdE K Transcriptional regulator
MNLHAPDI_01924 3.3e-106 yvdD 3.2.2.10 S Belongs to the LOG family
MNLHAPDI_01925 2.6e-52 yvdC S MazG nucleotide pyrophosphohydrolase domain
MNLHAPDI_01926 2.1e-288 sulP P COG0659 Sulfate permease and related transporters (MFS superfamily)
MNLHAPDI_01927 5.7e-106 ytiB 4.2.1.1 P Reversible hydration of carbon dioxide
MNLHAPDI_01928 1.3e-184 ghrB 1.1.1.215, 1.1.1.26, 1.1.1.43, 1.1.1.79, 1.1.1.81 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MNLHAPDI_01929 0.0 yxdM V ABC transporter (permease)
MNLHAPDI_01930 5.6e-141 yvcR V ABC transporter, ATP-binding protein
MNLHAPDI_01931 2.3e-198 yvcQ 2.7.13.3 T His Kinase A (phosphoacceptor) domain
MNLHAPDI_01932 3.9e-133 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MNLHAPDI_01933 1.8e-33
MNLHAPDI_01934 8.6e-147 nhoA 2.3.1.118 Q Belongs to the arylamine N-acetyltransferase family
MNLHAPDI_01935 1.6e-36 crh G Phosphocarrier protein Chr
MNLHAPDI_01936 1.4e-170 whiA K May be required for sporulation
MNLHAPDI_01937 7.3e-178 ybhK S Required for morphogenesis under gluconeogenic growth conditions
MNLHAPDI_01938 5.7e-166 rapZ S Displays ATPase and GTPase activities
MNLHAPDI_01939 1.8e-89 yvcI 3.6.1.55 F COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
MNLHAPDI_01940 1.4e-175 trxB 1.8.1.9 C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
MNLHAPDI_01941 1.4e-102 usp CBM50 M protein conserved in bacteria
MNLHAPDI_01942 2.4e-278 S COG0457 FOG TPR repeat
MNLHAPDI_01943 0.0 msbA2 3.6.3.44 V ABC transporter
MNLHAPDI_01945 1e-252
MNLHAPDI_01946 2.1e-70
MNLHAPDI_01947 4.4e-112 hisE 3.5.4.19, 3.6.1.31, 5.3.1.16 E belongs to the PRA-CH family
MNLHAPDI_01948 8.1e-137 hisF E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
MNLHAPDI_01949 1.9e-130 hisA 5.3.1.16 E 1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MNLHAPDI_01950 1.2e-114 hisH E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MNLHAPDI_01951 4.7e-108 hisB 1.1.1.23, 2.6.1.9, 3.1.3.15, 4.2.1.19 E imidazoleglycerol-phosphate dehydratase
MNLHAPDI_01952 3.3e-215 hisD 1.1.1.23, 1.1.1.308 E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MNLHAPDI_01953 7.4e-115 hisG 2.4.2.17 E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
MNLHAPDI_01954 2.4e-220 hisZ 2.4.2.17, 6.1.1.21 E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
MNLHAPDI_01955 4.5e-140 yvpB NU protein conserved in bacteria
MNLHAPDI_01956 5.5e-121 hrpW 4.2.2.10, 4.2.2.2 G Pectate lyase
MNLHAPDI_01957 3e-82 yvoF S COG0110 Acetyltransferase (isoleucine patch superfamily)
MNLHAPDI_01958 1.3e-119 ppaX 3.1.3.18, 3.6.1.1 S Hydrolyzes pyrophosphate formed during P-Ser-HPr dephosphorylation by HPrK P. Might play a role in controlling the intracellular pyrophosphate pool
MNLHAPDI_01959 1.5e-164 yvoD P COG0370 Fe2 transport system protein B
MNLHAPDI_01960 4.9e-148 lgt 2.1.1.199 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MNLHAPDI_01961 1.7e-168 hprK F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MNLHAPDI_01962 6.8e-223 nagA 3.5.1.25 G Belongs to the metallo-dependent hydrolases superfamily. NagA family
MNLHAPDI_01963 8.9e-133 nagB 3.1.1.31, 3.5.99.6 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
MNLHAPDI_01964 3.6e-134 yvoA K transcriptional
MNLHAPDI_01965 0.0 yvnB 3.1.4.53 Q Calcineurin-like phosphoesterase
MNLHAPDI_01966 8.5e-84 adcR K helix_turn_helix multiple antibiotic resistance protein
MNLHAPDI_01967 8.2e-232 cypX 1.14.15.13 C Cytochrome P450
MNLHAPDI_01968 1.6e-137 yvmC 2.3.2.22 S Involved in the biosynthesis of pulcherrimin, a red extracellular pigment. It uses activated amino acids in the form of aminoacyl-tRNAs (aa-tRNAs) as substrates to catalyze the ATP- independent formation of cyclodipeptides which are intermediates in diketopiperazine (DKP) biosynthetic pathways. Catalyzes the formation of cyclo(L-Leu-L-Leu) (cLL) from L-leucyl-tRNA(Leu). Can also incorporate various nonpolar residues, such as L- phenylalanine, L-leucine and methionine, into cyclodipeptides
MNLHAPDI_01969 3e-87 yvmB K helix_turn_helix multiple antibiotic resistance protein
MNLHAPDI_01970 2.7e-203 yvmA EGP Major facilitator Superfamily
MNLHAPDI_01971 1.2e-50 yvlD S Membrane
MNLHAPDI_01972 2.6e-26 pspB KT PspC domain
MNLHAPDI_01973 3.4e-168 yvlB S Putative adhesin
MNLHAPDI_01974 8e-49 yvlA
MNLHAPDI_01975 6.7e-34 yvkN
MNLHAPDI_01976 2.9e-79 fliC N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MNLHAPDI_01977 0.0 uvrA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
MNLHAPDI_01978 0.0 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
MNLHAPDI_01979 1.2e-30 csbA S protein conserved in bacteria
MNLHAPDI_01980 0.0 yvkC 2.7.9.2 GT Phosphotransferase
MNLHAPDI_01981 7e-101 yvkB K Transcriptional regulator
MNLHAPDI_01982 7.9e-228 yvkA EGP Major facilitator Superfamily
MNLHAPDI_01983 4.9e-221 minJ O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MNLHAPDI_01984 5.3e-56 swrA S Swarming motility protein
MNLHAPDI_01985 6.9e-270 ctpB 3.4.21.102 M Belongs to the peptidase S41A family
MNLHAPDI_01986 2.1e-155 ftsX D Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation
MNLHAPDI_01987 1.6e-123 ftsE D cell division ATP-binding protein FtsE
MNLHAPDI_01988 5.3e-56 cccB C COG2010 Cytochrome c, mono- and diheme variants
MNLHAPDI_01989 5.5e-142 yvjA S Uncharacterized protein conserved in bacteria (DUF2179)
MNLHAPDI_01990 6.1e-185 prfB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MNLHAPDI_01991 0.0 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
MNLHAPDI_01992 2.2e-102 hpf J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MNLHAPDI_01993 2.8e-66
MNLHAPDI_01994 1.9e-08 fliT S bacterial-type flagellum organization
MNLHAPDI_01995 2.9e-69 fliS N flagellar protein FliS
MNLHAPDI_01996 1.3e-266 fliD N morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
MNLHAPDI_01997 6.1e-57 flaG N flagellar protein FlaG
MNLHAPDI_01998 1.9e-156 fliC N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MNLHAPDI_01999 2e-30 csrA T Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
MNLHAPDI_02000 2.7e-73 fliW S Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
MNLHAPDI_02001 2.6e-50 yviE
MNLHAPDI_02002 1.1e-156 flgL N Belongs to the bacterial flagellin family
MNLHAPDI_02003 7.8e-264 flgK N flagellar hook-associated protein
MNLHAPDI_02004 2.4e-78 flgN NOU FlgN protein
MNLHAPDI_02005 4.2e-40 flgM KNU Negative regulator of flagellin synthesis
MNLHAPDI_02006 6e-73 yvyF S flagellar protein
MNLHAPDI_02007 2.7e-129 comFC S Phosphoribosyl transferase domain
MNLHAPDI_02008 5.7e-46 comFB S Late competence development protein ComFB
MNLHAPDI_02009 5.6e-269 comFA L COG4098 Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
MNLHAPDI_02010 7.3e-155 degV S protein conserved in bacteria
MNLHAPDI_02011 2e-126 degU KT COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MNLHAPDI_02012 5.1e-183 degS 2.7.13.3 T Member of the two-component regulatory system DegS DegU, which plays an important role in the transition growth phase
MNLHAPDI_02013 2e-120 yvyE 3.4.13.9 S Domain of unknown function (DUF1949)
MNLHAPDI_02014 6e-163 yvhJ K Transcriptional regulator
MNLHAPDI_02015 2.6e-181 tagO 2.7.8.33, 2.7.8.35 M COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase UDP-N-acetylglucosamine-1-phosphate transferase
MNLHAPDI_02016 4.4e-238 tuaH M Teichuronic acid biosynthesis glycosyltransferase tuaH
MNLHAPDI_02017 2.1e-145 tuaG GT2 M Glycosyltransferase like family 2
MNLHAPDI_02018 6e-115 tuaF M protein involved in exopolysaccharide biosynthesis
MNLHAPDI_02019 1.7e-263 tuaE M Teichuronic acid biosynthesis protein
MNLHAPDI_02020 4.5e-258 tuaD 1.1.1.22 M Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MNLHAPDI_02021 7.6e-219 tuaC 2.4.1.21, 3.2.1.1 GH13,GT4,GT5 GM Teichuronic acid
MNLHAPDI_02022 4.4e-248 wzxC S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
MNLHAPDI_02023 4.6e-112 tuaA M COG2148 Sugar transferases involved in lipopolysaccharide synthesis
MNLHAPDI_02024 3e-268 lytC 3.5.1.28 M n-acetylmuramoyl-L-alanine amidase
MNLHAPDI_02025 0.0 lytB 3.5.1.28 D Stage II sporulation protein
MNLHAPDI_02026 6e-38
MNLHAPDI_02027 6.1e-163 lytR K May catalyze the final step in cell wall teichoic acid biosynthesis, the transfer of the anionic cell wall polymers (APs) from their lipid-linked precursor to the cell wall peptidoglycan (PG)
MNLHAPDI_02028 8.2e-218 mnaA 5.1.3.14 M Belongs to the UDP-N-acetylglucosamine 2-epimerase family
MNLHAPDI_02029 9e-164 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
MNLHAPDI_02030 0.0 ggaB GT2 M CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
MNLHAPDI_02031 8.1e-257 ggaA M Glycosyltransferase like family 2
MNLHAPDI_02033 1.6e-100 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
MNLHAPDI_02034 1.8e-279 tagH 3.6.3.38, 3.6.3.40 GM Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system
MNLHAPDI_02035 1.1e-150 tagG GM Transport permease protein
MNLHAPDI_02036 0.0 tagF 2.7.8.12 M glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MNLHAPDI_02037 0.0 tagE 2.4.1.52 GT4 M Glycosyl transferase 1 domain A
MNLHAPDI_02038 5.7e-70 tagD 2.7.7.15, 2.7.7.39 IM Cytidylyltransferase
MNLHAPDI_02039 1.8e-144 tagA 2.4.1.187 GT26 M Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid
MNLHAPDI_02040 5e-215 tagB 2.7.8.14, 2.7.8.44, 2.7.8.47 M glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MNLHAPDI_02041 1.2e-260
MNLHAPDI_02042 7.2e-217 atl 3.2.1.96, 3.5.1.28 GH73 G Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
MNLHAPDI_02043 7.1e-191 pmi 5.3.1.8 G mannose-6-phosphate isomerase
MNLHAPDI_02044 3.5e-266 gerBA EG Spore germination protein
MNLHAPDI_02045 7.5e-200 gerBB E Spore germination protein
MNLHAPDI_02046 7.6e-216 gerAC S Spore germination protein
MNLHAPDI_02047 1.9e-248 ywtG EGP Major facilitator Superfamily
MNLHAPDI_02048 8.4e-171 ywtF K Transcriptional regulator
MNLHAPDI_02049 7e-161 ywtE 3.1.3.104 S hydrolases of the HAD superfamily
MNLHAPDI_02050 5.4e-240 pgdS CBM50 M COG0791 Cell wall-associated hydrolases (invasion-associated proteins)
MNLHAPDI_02051 3.6e-21 ywtC
MNLHAPDI_02052 1.7e-218 capA M enzyme of poly-gamma-glutamate biosynthesis (capsule formation)
MNLHAPDI_02053 8.6e-70 pgsC S biosynthesis protein
MNLHAPDI_02054 6.1e-224 murD 6.3.2.9 M COG0769 UDP-N-acetylmuramyl tripeptide synthase
MNLHAPDI_02055 1.9e-178 rbsR K transcriptional
MNLHAPDI_02056 2.9e-162 rbsK 2.7.1.15, 2.7.1.4 H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MNLHAPDI_02057 2.8e-64 rbsD 5.4.99.62 G Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose
MNLHAPDI_02058 2.3e-276 rbsA 3.6.3.17 G Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system
MNLHAPDI_02059 1.4e-154 rbsC G Belongs to the binding-protein-dependent transport system permease family
MNLHAPDI_02060 4.4e-161 rbsB G COG1879 ABC-type sugar transport system, periplasmic component
MNLHAPDI_02061 4.6e-94 batE T Sh3 type 3 domain protein
MNLHAPDI_02062 3.6e-48 ywsA S Protein of unknown function (DUF3892)
MNLHAPDI_02063 1.5e-97 ywrO S NADPH-quinone reductase (modulator of drug activity B)
MNLHAPDI_02064 1.3e-145 budA 4.1.1.5 H Alpha-acetolactate decarboxylase
MNLHAPDI_02065 0.0 alsS 2.2.1.6 EH Belongs to the TPP enzyme family
MNLHAPDI_02066 1.1e-169 alsR K LysR substrate binding domain
MNLHAPDI_02067 5.5e-220 ywrK P Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MNLHAPDI_02068 9.2e-124 ywrJ
MNLHAPDI_02069 7.6e-131 cotB
MNLHAPDI_02070 3.5e-210 cotH M Spore Coat
MNLHAPDI_02071 3.7e-12
MNLHAPDI_02072 8.1e-111 ywrF S COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MNLHAPDI_02073 2.9e-54 S Domain of unknown function (DUF4181)
MNLHAPDI_02074 6.3e-309 ggt 2.3.2.2, 3.4.19.13 E gamma-glutamyltransferase
MNLHAPDI_02075 8e-82 ywrC K Transcriptional regulator
MNLHAPDI_02076 1.2e-103 ywrB P Chromate transporter
MNLHAPDI_02077 9.9e-89 ywrA P COG2059 Chromate transport protein ChrA
MNLHAPDI_02079 5.7e-100 ywqN S NAD(P)H-dependent
MNLHAPDI_02080 4.9e-162 K Transcriptional regulator
MNLHAPDI_02081 1.9e-116 nfi 3.1.21.7 L DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA
MNLHAPDI_02082 1.9e-24
MNLHAPDI_02083 4.6e-242 ywqJ S Pre-toxin TG
MNLHAPDI_02084 3.9e-38 ywqI S Family of unknown function (DUF5344)
MNLHAPDI_02085 9.7e-23 S Domain of unknown function (DUF5082)
MNLHAPDI_02086 1.3e-153 ywqG S Domain of unknown function (DUF1963)
MNLHAPDI_02087 3e-248 ugd 1.1.1.22 M Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MNLHAPDI_02088 1.4e-141 ywqE 3.1.3.48 GM COG4464 Capsular polysaccharide biosynthesis protein
MNLHAPDI_02089 1.1e-119 ywqD 2.7.10.1 D COG0489 ATPases involved in chromosome partitioning
MNLHAPDI_02090 2e-116 ywqC M biosynthesis protein
MNLHAPDI_02091 1.2e-17
MNLHAPDI_02092 3.8e-309 ywqB S SWIM zinc finger
MNLHAPDI_02093 0.0 ywqA L COG0553 Superfamily II DNA RNA helicases, SNF2 family
MNLHAPDI_02094 2.3e-156 ywpJ 3.1.3.104 S hydrolases of the HAD superfamily
MNLHAPDI_02095 8.8e-139 glcR K COG1349 Transcriptional regulators of sugar metabolism
MNLHAPDI_02096 9.8e-58 ssbB L Single-stranded DNA-binding protein
MNLHAPDI_02097 3.8e-66 ywpG
MNLHAPDI_02098 1.1e-66 ywpF S YwpF-like protein
MNLHAPDI_02099 1.2e-49 srtA 3.4.22.70 M Sortase family
MNLHAPDI_02100 7e-153 ywpD T Histidine kinase
MNLHAPDI_02101 3.9e-50 mscL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
MNLHAPDI_02102 4.6e-82 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
MNLHAPDI_02103 2.1e-199 S aspartate phosphatase
MNLHAPDI_02104 1.5e-141 flhP N flagellar basal body
MNLHAPDI_02105 6.9e-126 flhO N flagellar basal body
MNLHAPDI_02106 3.5e-180 mbl D Rod shape-determining protein
MNLHAPDI_02107 3e-44 spoIIID K Stage III sporulation protein D
MNLHAPDI_02108 2.1e-70 ywoH K COG1846 Transcriptional regulators
MNLHAPDI_02109 2.7e-211 ywoG EGP Major facilitator Superfamily
MNLHAPDI_02110 1.2e-231 ywoF P Right handed beta helix region
MNLHAPDI_02111 3e-281 ybbW FH COG1953 Cytosine uracil thiamine allantoin permeases
MNLHAPDI_02112 4.4e-242 ywoD EGP Major facilitator superfamily
MNLHAPDI_02113 4e-104 phzA Q Isochorismatase family
MNLHAPDI_02114 7.5e-77
MNLHAPDI_02115 3.3e-225 amt P Ammonium transporter
MNLHAPDI_02116 1.6e-58 nrgB K Belongs to the P(II) protein family
MNLHAPDI_02117 3.4e-103 bcrC 3.6.1.27 I COG0671 Membrane-associated phospholipid phosphatase
MNLHAPDI_02118 3e-72 ywnJ S VanZ like family
MNLHAPDI_02119 5.3e-116 spoIIQ M COG0739 Membrane proteins related to metalloendopeptidases
MNLHAPDI_02120 4.1e-89 ywnH 2.3.1.183 M COG1247 Sortase and related acyltransferases
MNLHAPDI_02121 8.9e-10 ywnC S Family of unknown function (DUF5362)
MNLHAPDI_02122 2.2e-70 ywnF S Family of unknown function (DUF5392)
MNLHAPDI_02123 1.2e-277 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MNLHAPDI_02124 5e-142 mta K transcriptional
MNLHAPDI_02125 2.6e-59 ywnC S Family of unknown function (DUF5362)
MNLHAPDI_02126 1.6e-114 ywnB S NAD(P)H-binding
MNLHAPDI_02127 1.7e-64 ywnA K Transcriptional regulator
MNLHAPDI_02128 0.0 ureC 3.5.1.5 E Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family
MNLHAPDI_02129 5.9e-64 ureB 3.5.1.5 E Belongs to the urease beta subunit family
MNLHAPDI_02130 6.3e-51 ureA 3.5.1.5 E Belongs to the urease gamma subunit family
MNLHAPDI_02132 3.8e-11 csbD K CsbD-like
MNLHAPDI_02133 3e-84 ywmF S Peptidase M50
MNLHAPDI_02134 1.3e-103 S response regulator aspartate phosphatase
MNLHAPDI_02135 7e-192 moaA 4.1.99.22, 4.6.1.17 H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MNLHAPDI_02136 2.6e-146 fdhD C Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MNLHAPDI_02138 7.2e-121 ywmD S protein containing a von Willebrand factor type A (vWA) domain
MNLHAPDI_02139 1.7e-122 ywmC S protein containing a von Willebrand factor type A (vWA) domain
MNLHAPDI_02140 3.5e-175 spoIID D Stage II sporulation protein D
MNLHAPDI_02141 1.2e-241 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MNLHAPDI_02142 1.6e-134 ywmB S TATA-box binding
MNLHAPDI_02143 1.3e-32 ywzB S membrane
MNLHAPDI_02144 1.3e-60 ywmA
MNLHAPDI_02145 1.4e-13 ywmA
MNLHAPDI_02146 5.9e-54 atpC C Produces ATP from ADP in the presence of a proton gradient across the membrane
MNLHAPDI_02147 1.2e-266 atpD 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MNLHAPDI_02148 1.1e-150 atpG C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MNLHAPDI_02149 6.9e-281 atpA 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MNLHAPDI_02150 1.1e-90 atpH C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MNLHAPDI_02151 3.8e-45 atpF C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MNLHAPDI_02152 1.6e-26 atpE C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MNLHAPDI_02153 4.6e-129 atpB C it plays a direct role in the translocation of protons across the membrane
MNLHAPDI_02154 2.5e-62 atpI S ATP synthase
MNLHAPDI_02155 4.7e-114 upp 2.4.2.9 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MNLHAPDI_02156 2.1e-238 glyA 2.1.2.1 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MNLHAPDI_02157 7.2e-95 ywlG S Belongs to the UPF0340 family
MNLHAPDI_02158 1.7e-81 rpiB 5.3.1.6 G Ribose 5-phosphate isomerase
MNLHAPDI_02159 1.7e-78 ywlE 3.1.3.48, 3.9.1.2, 5.3.1.6 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MNLHAPDI_02160 1.7e-91 mntP P Probably functions as a manganese efflux pump
MNLHAPDI_02161 2.8e-196 ywlC 2.7.7.87, 3.1.3.48 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
MNLHAPDI_02162 1.2e-76 ywlB 1.20.4.1, 2.3.1.1 E Belongs to the acetyltransferase family. ArgA subfamily
MNLHAPDI_02163 6.1e-112 spoIIR S stage II sporulation protein R
MNLHAPDI_02164 9.8e-56 ywlA S Uncharacterised protein family (UPF0715)
MNLHAPDI_02166 5e-159 prmC 2.1.1.297 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
MNLHAPDI_02167 9.5e-192 prfA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MNLHAPDI_02168 8.2e-69 yaeR E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
MNLHAPDI_02169 1.7e-91 racA K Required for the formation of axial filaments and for anchoring the origin regions at the cell poles in sporulating cells, thus ensuring proper chromosome segregation in the prespore. Binds in a dispersed manner throughout the chromosome but preferentially to sites clustered in the origin portion of the chromosome, causing condensation of the chromosome and its remodeling into an elongated, anchored structure
MNLHAPDI_02170 8.6e-160 ywkB S Membrane transport protein
MNLHAPDI_02171 0.0 sfcA 1.1.1.38 C malic enzyme
MNLHAPDI_02172 1.6e-103 tdk 2.7.1.21 F thymidine kinase
MNLHAPDI_02173 1.1e-32 rpmE J Binds the 23S rRNA
MNLHAPDI_02174 2.8e-238 rho K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MNLHAPDI_02175 1.9e-175 glpX 3.1.3.11, 3.1.3.37 G fructose-1,6-bisphosphatase
MNLHAPDI_02176 8.6e-240 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MNLHAPDI_02177 1.5e-112 tal 2.2.1.2 G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MNLHAPDI_02178 7.2e-158 fbaA 4.1.2.13, 4.1.2.29 G Aldolase
MNLHAPDI_02179 1.1e-62 spo0F T COG0784 FOG CheY-like receiver
MNLHAPDI_02180 6e-91 ywjG S Domain of unknown function (DUF2529)
MNLHAPDI_02181 0.0 pyrG 6.3.4.2 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
MNLHAPDI_02182 1.1e-49 rpoE K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
MNLHAPDI_02183 4.8e-210 acdA 1.3.8.1, 1.3.8.7 I acyl-CoA dehydrogenase
MNLHAPDI_02184 0.0 fadF C COG0247 Fe-S oxidoreductase
MNLHAPDI_02185 1.5e-222 clsB I Belongs to the phospholipase D family. Cardiolipin synthase subfamily
MNLHAPDI_02186 5.6e-183 uvsE L Component in a DNA repair pathway. Removal of UV-light damaged nucleotides. Recognizes pyrimidine dimers and cleave a phosphodiester bond immediately 5' to the lesion
MNLHAPDI_02187 2.7e-42 ywjC
MNLHAPDI_02188 5.9e-94 ywjB H RibD C-terminal domain
MNLHAPDI_02189 0.0 ywjA V ABC transporter
MNLHAPDI_02190 7.9e-285 ywiE I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MNLHAPDI_02191 3.1e-124 narI 1.7.5.1 C nitrate reductase, gamma
MNLHAPDI_02192 1.2e-94 narJ 1.7.5.1 C nitrate reductase
MNLHAPDI_02193 1.9e-296 narH 1.7.5.1 C Nitrate reductase, beta
MNLHAPDI_02194 0.0 narG 1.7.5.1 C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MNLHAPDI_02195 7e-86 arfM T cyclic nucleotide binding
MNLHAPDI_02196 1.7e-139 ywiC S YwiC-like protein
MNLHAPDI_02197 7.7e-129 fnr K helix_turn_helix, cAMP Regulatory protein
MNLHAPDI_02198 2.3e-213 narK P COG2223 Nitrate nitrite transporter
MNLHAPDI_02199 0.0 argS 6.1.1.19 J Arginyl-tRNA synthetase
MNLHAPDI_02200 4.7e-73 ywiB S protein conserved in bacteria
MNLHAPDI_02201 1e-07 S Bacteriocin subtilosin A
MNLHAPDI_02202 4.9e-270 C Fe-S oxidoreductases
MNLHAPDI_02204 3.3e-132 cbiO V ABC transporter
MNLHAPDI_02205 3.2e-234 mgtA 3.6.3.2 P ATPase, P-type transporting, HAD superfamily, subfamily IC
MNLHAPDI_02206 4.2e-217 2.7.1.26, 2.7.7.2 L Peptidase, M16
MNLHAPDI_02207 1.2e-249 L Peptidase, M16
MNLHAPDI_02209 9.2e-248 ywhL CO amine dehydrogenase activity
MNLHAPDI_02210 2.7e-191 ywhK CO amine dehydrogenase activity
MNLHAPDI_02211 3.1e-79 S aspartate phosphatase
MNLHAPDI_02213 1.6e-26 ywhH S Aminoacyl-tRNA editing domain
MNLHAPDI_02214 9.2e-169 speB 3.5.3.11 E Belongs to the arginase family
MNLHAPDI_02215 1.4e-158 speE 2.5.1.16 E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MNLHAPDI_02216 0.0 pbpG 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
MNLHAPDI_02217 8.9e-95 ywhD S YwhD family
MNLHAPDI_02218 3.3e-118 ywhC S Peptidase family M50
MNLHAPDI_02219 2.7e-25 dmpI 5.3.2.6 G 4-oxalocrotonate tautomerase
MNLHAPDI_02220 9.5e-71 ywhA K Transcriptional regulator
MNLHAPDI_02221 2.7e-293 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MNLHAPDI_02222 2.1e-65 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MNLHAPDI_02224 2e-237 mmr U Major Facilitator Superfamily
MNLHAPDI_02225 1.5e-77 yffB K Transcriptional regulator
MNLHAPDI_02226 5.4e-89 ywgA 2.1.1.72, 3.1.21.3
MNLHAPDI_02227 4.3e-255 ywfO S COG1078 HD superfamily phosphohydrolases
MNLHAPDI_02228 3.1e-36 ywzC S Belongs to the UPF0741 family
MNLHAPDI_02229 1e-110 rsfA_1
MNLHAPDI_02230 5.7e-158 ywfM EG EamA-like transporter family
MNLHAPDI_02231 6.6e-156 lipL 2.3.1.200, 2.3.1.204 H Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes
MNLHAPDI_02232 9.2e-164 cysL K Transcriptional regulator
MNLHAPDI_02233 5.6e-175 pta 2.3.1.19, 2.3.1.8, 3.6.3.21 C In Salmonella this enzyme is required for ethanolamine catabolism
MNLHAPDI_02234 1.1e-146 ywfI C May function as heme-dependent peroxidase
MNLHAPDI_02235 4.9e-137 IQ Enoyl-(Acyl carrier protein) reductase
MNLHAPDI_02236 7.8e-235 ywfG 2.6.1.83 E Aminotransferase class I and II
MNLHAPDI_02237 8.6e-210 bacE EGP Major facilitator Superfamily
MNLHAPDI_02238 1.8e-270 purD 6.3.2.49, 6.3.4.13 F Part of the bacABCDEFG operon responsible for the biosynthesis of bacilysin, an irreversible inactivator of the glutaminase domain of glucosamine synthetase. Catalyzes the formation of alpha-dipeptides from various L-amino acids in the presence of ATP. In vivo catalyzes the ligation of L-alanine and L-anticapsin (epoxycyclohexanonyl-Ala) to produce the final bacilysin antibiotic (L-Ala-L-4S-cyclohexenonyl-Ala dipeptide)
MNLHAPDI_02239 5.6e-138 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MNLHAPDI_02240 1.3e-136 bacB 5.3.3.19, 5.4.99.5 S Part of the bacABCDEF operon responsible for the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase. BacB catalyzes the allylic isomerization of the
MNLHAPDI_02241 8.6e-113 pheA 1.1.1.3, 1.3.1.12, 4.1.1.100, 4.2.1.51, 5.4.99.5 E Part of the bacABCDEF operon responsible for the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase. BacA is an unusual prephenate decarboxylase that avoids the typical aromatization of the cyclohexadienol ring of prephenate. BacA catalyzes the protonation of prephenate (1-carboxy-4-hydroxy-alpha-oxo-2,5-cyclohexadiene-1- propanoic acid) at C6 position, followed by a decarboxylation to produce the endocyclic-delta(4),delta(8)-7R-dihydro- hydroxyphenylpyruvate (en-H2HPP). En-H2HPP is able to undergo a slow nonenzymatic isomerization to produce the exocyclic- delta(3),delta(5)-dihydro-hydroxyphenylpyruvate (ex-H2HPP). BacA isomerizes only the pro-R double bond in prephenate
MNLHAPDI_02242 3.3e-204 ywfA EGP Major facilitator Superfamily
MNLHAPDI_02243 4.4e-261 lysP E amino acid
MNLHAPDI_02244 0.0 rocB E arginine degradation protein
MNLHAPDI_02245 1.6e-296 putA 1.2.1.88, 1.5.5.2 C Belongs to the aldehyde dehydrogenase family. RocA subfamily
MNLHAPDI_02246 8.3e-243 rocG 1.4.1.2, 1.4.1.3 E Belongs to the Glu Leu Phe Val dehydrogenases family
MNLHAPDI_02247 3.4e-77
MNLHAPDI_02248 1.3e-86 spsL 5.1.3.13 M Spore Coat
MNLHAPDI_02249 2.2e-159 spsK 1.1.1.133 M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
MNLHAPDI_02250 1e-181 rfbB 4.2.1.46 M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
MNLHAPDI_02251 3.2e-138 spsI 2.7.7.24 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MNLHAPDI_02252 1.4e-187 spsG M Spore Coat
MNLHAPDI_02253 1.8e-130 spsF M Spore Coat
MNLHAPDI_02254 7.1e-214 spsE 2.5.1.56 M acid synthase
MNLHAPDI_02255 4.4e-163 spsD 2.3.1.210 K Spore Coat
MNLHAPDI_02256 1.3e-223 spsC E Belongs to the DegT DnrJ EryC1 family
MNLHAPDI_02257 1.5e-269 spsB M Capsule polysaccharide biosynthesis protein
MNLHAPDI_02258 2.8e-145 spsA M Spore Coat
MNLHAPDI_02259 4.8e-75 gerQ S Essential for the localization of CwlJ in the spore coat and for spore germination triggered by calcium and dipicolinic acid (DPA). Its assembly into the spore coat is dependent on the coat morphogenetic proteins CotE and SpoIVA
MNLHAPDI_02260 4.3e-59 ywdK S small membrane protein
MNLHAPDI_02261 1.3e-238 ywdJ F Xanthine uracil
MNLHAPDI_02262 7.7e-49 ywdI S Family of unknown function (DUF5327)
MNLHAPDI_02263 1.1e-261 ywdH 1.2.1.3 C Belongs to the aldehyde dehydrogenase family
MNLHAPDI_02264 1.1e-129 ung 3.2.2.27 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MNLHAPDI_02265 5.5e-152 ywdF GT2,GT4 S Glycosyltransferase like family 2
MNLHAPDI_02267 1.4e-113 ywdD
MNLHAPDI_02268 1.3e-57 pex K Transcriptional regulator PadR-like family
MNLHAPDI_02269 2.5e-144 thiD 2.5.1.3, 2.7.1.35, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Phosphomethylpyrimidine kinase
MNLHAPDI_02270 2e-28 ywdA
MNLHAPDI_02271 1.1e-286 scrB 3.2.1.26, 3.2.1.65, 3.2.1.80 GH32 G invertase
MNLHAPDI_02272 1.8e-251 scrA 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
MNLHAPDI_02273 6.7e-139 focA P Formate/nitrite transporter
MNLHAPDI_02274 7e-150 sacT K transcriptional antiterminator
MNLHAPDI_02276 0.0 vpr O Belongs to the peptidase S8 family
MNLHAPDI_02277 3.3e-186 ywcH C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MNLHAPDI_02278 6.1e-137 nfrA 1.5.1.38, 1.5.1.39 C Oxidoreductase
MNLHAPDI_02279 1.2e-200 rodA D Belongs to the SEDS family
MNLHAPDI_02280 6e-39 ywcE S Required for proper spore morphogenesis. Important for spore germination
MNLHAPDI_02281 2.6e-64 qoxD 1.10.3.12, 1.9.3.1 C quinol oxidase, subunit
MNLHAPDI_02282 1.2e-111 qoxC 1.10.3.12, 1.9.3.1 C quinol oxidase, subunit
MNLHAPDI_02283 0.0 qoxB 1.10.3.12, 1.9.3.1 C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MNLHAPDI_02284 2.1e-177 cyoA 1.10.3.10, 1.10.3.12 C Catalyzes quinol oxidation with the concomitant reduction of oxygen to water. Subunit II transfers the electrons from a quinol to the binuclear center of the catalytic subunit I
MNLHAPDI_02285 1e-35 ywzA S membrane
MNLHAPDI_02286 1.6e-304 galT 2.7.7.12 G UDP-glucose--hexose-1-phosphate uridylyltransferase
MNLHAPDI_02287 1.4e-225 galK 2.7.1.6 G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MNLHAPDI_02288 9.5e-60 gtcA S GtrA-like protein
MNLHAPDI_02289 1.1e-121 ywcC K transcriptional regulator
MNLHAPDI_02291 2.9e-48 ywcB S Protein of unknown function, DUF485
MNLHAPDI_02292 4e-268 ywcA S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MNLHAPDI_02293 4e-110 ywbO Q dithiol-disulfide isomerase involved in polyketide biosynthesis
MNLHAPDI_02294 4.9e-224 ywbN P Dyp-type peroxidase family protein
MNLHAPDI_02295 4.2e-185 ycdO P periplasmic lipoprotein involved in iron transport
MNLHAPDI_02296 6.7e-249 P COG0672 High-affinity Fe2 Pb2 permease
MNLHAPDI_02297 1.4e-113 thiE 2.5.1.3, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
MNLHAPDI_02298 3.4e-141 thiM 2.7.1.50 H Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
MNLHAPDI_02299 1.6e-152 ywbI K Transcriptional regulator
MNLHAPDI_02300 6.5e-58 ywbH S Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein. When a cell is stressed by the addition of antibiotics or by other factors in the environment, CidA possibly oligomerizes within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are also hypothesized to regulate the subsequent cell lysis by either allowing the murein hydrolases access to the cell wall substrate and or regulating their activity by a
MNLHAPDI_02301 2.3e-111 ywbG M effector of murein hydrolase
MNLHAPDI_02302 2.4e-207 ywbF EGP Major facilitator Superfamily
MNLHAPDI_02303 2.3e-27 ywbE S Uncharacterized conserved protein (DUF2196)
MNLHAPDI_02304 1e-218 ywbD 2.1.1.191 J Methyltransferase
MNLHAPDI_02305 9.9e-67 ywbC 4.4.1.5 E glyoxalase
MNLHAPDI_02306 6.1e-120 ywbB S Protein of unknown function (DUF2711)
MNLHAPDI_02307 4.6e-244 celB G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
MNLHAPDI_02308 3e-273 epr 3.4.21.62 O Belongs to the peptidase S8 family
MNLHAPDI_02309 5.2e-243 scrA 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
MNLHAPDI_02310 6e-149 sacY K transcriptional antiterminator
MNLHAPDI_02311 2.9e-167 gspA M General stress
MNLHAPDI_02312 8.2e-123 ywaF S Integral membrane protein
MNLHAPDI_02313 2.3e-87 ywaE K Transcriptional regulator
MNLHAPDI_02314 1.2e-230 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MNLHAPDI_02315 9.8e-250 ywaD 3.4.11.10, 3.4.11.6 S PA domain
MNLHAPDI_02316 8.1e-93 K Helix-turn-helix XRE-family like proteins
MNLHAPDI_02317 4.2e-49 4.1.1.44 S Carboxymuconolactone decarboxylase family
MNLHAPDI_02318 1e-130 ynfM EGP Major facilitator Superfamily
MNLHAPDI_02319 5e-116 ywaC 2.7.6.5 S protein conserved in bacteria
MNLHAPDI_02320 5.4e-167 menA 2.5.1.74 H Belongs to the MenA family. Type 1 subfamily
MNLHAPDI_02321 5e-14 S D-Ala-teichoic acid biosynthesis protein
MNLHAPDI_02322 5.1e-292 dltA 6.1.1.13 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MNLHAPDI_02323 1.2e-232 dltB M membrane protein involved in D-alanine export
MNLHAPDI_02324 1.5e-36 dltC 6.1.1.13 IQ Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MNLHAPDI_02325 2.3e-231 dltD M COG3966 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MNLHAPDI_02326 6.6e-139 dltE M Belongs to the short-chain dehydrogenases reductases (SDR) family
MNLHAPDI_02327 3.1e-206 ilvE 2.6.1.42 E Branched-chain amino acid aminotransferase
MNLHAPDI_02328 1.1e-253 licH 3.2.1.86 GT4 G COG1486 Alpha-galactosidases 6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases
MNLHAPDI_02329 8.7e-51 licA 2.7.1.196, 2.7.1.205 G phosphotransferase system
MNLHAPDI_02330 2.8e-249 licC G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
MNLHAPDI_02331 2.3e-50 licB 2.7.1.196, 2.7.1.205 G transporter subunit IIB
MNLHAPDI_02332 0.0 licR 2.7.1.202 GKT Mga helix-turn-helix domain
MNLHAPDI_02333 1.1e-19 yxzF
MNLHAPDI_02334 1e-110 mpg 3.2.2.21 L Belongs to the DNA glycosylase MPG family
MNLHAPDI_02335 0.0 katX 1.11.1.6 P serves to protect cells from the toxic effects of hydrogen peroxide
MNLHAPDI_02336 5.3e-215 yxlH EGP Major facilitator Superfamily
MNLHAPDI_02337 1.8e-139 yxlG S COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
MNLHAPDI_02338 5.1e-167 yxlF V ABC transporter, ATP-binding protein
MNLHAPDI_02339 7.6e-28 yxlE S Phospholipase_D-nuclease N-terminal
MNLHAPDI_02340 1.2e-31
MNLHAPDI_02341 3.9e-48 yxlC S Family of unknown function (DUF5345)
MNLHAPDI_02342 4.7e-91 sigY K Belongs to the sigma-70 factor family. ECF subfamily
MNLHAPDI_02343 2.3e-254 yxlA F Belongs to the purine-cytosine permease (2.A.39) family
MNLHAPDI_02344 8e-162 nnrD 4.2.1.136, 5.1.99.6 G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MNLHAPDI_02345 0.0 cydD V ATP-binding protein
MNLHAPDI_02346 0.0 cydD V ATP-binding
MNLHAPDI_02347 2.9e-190 cydB 1.10.3.14 C Cytochrome d ubiquinol oxidase, subunit II
MNLHAPDI_02348 1.3e-268 cydA 1.10.3.14 C oxidase, subunit
MNLHAPDI_02349 1.5e-229 cimH C COG3493 Na citrate symporter
MNLHAPDI_02350 0.0 3.4.24.84 O Peptidase family M48
MNLHAPDI_02352 3e-156 yxkH G Polysaccharide deacetylase
MNLHAPDI_02353 5.9e-205 msmK P Belongs to the ABC transporter superfamily
MNLHAPDI_02354 4.8e-165 lrp QT PucR C-terminal helix-turn-helix domain
MNLHAPDI_02355 2.5e-275 aldY 1.2.1.3 C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
MNLHAPDI_02356 7.3e-147 yxkD S Uncharacterised 5xTM membrane BCR, YitT family COG1284
MNLHAPDI_02357 1.1e-73 yxkC S Domain of unknown function (DUF4352)
MNLHAPDI_02358 4.6e-196 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
MNLHAPDI_02359 3.4e-77 S Protein of unknown function (DUF1453)
MNLHAPDI_02360 6.1e-187 yxjM T Signal transduction histidine kinase
MNLHAPDI_02361 8.9e-116 K helix_turn_helix, Lux Regulon
MNLHAPDI_02362 3.6e-235 pepT 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
MNLHAPDI_02365 1e-87 yxjI S LURP-one-related
MNLHAPDI_02366 5.5e-222 yxjG 2.1.1.14 E Methionine synthase
MNLHAPDI_02367 1e-220 yxjG 2.1.1.14 E Methionine synthase
MNLHAPDI_02368 1.3e-137 IQ Catalyzes the formation of acetoacetate from 3-hydroxybutyrate
MNLHAPDI_02369 5.2e-116 scoB 2.8.3.5 I COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit
MNLHAPDI_02370 1.4e-130 scoA 2.8.3.5 I COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MNLHAPDI_02371 2.6e-253 yxjC EG COG2610 H gluconate symporter and related permeases
MNLHAPDI_02372 3.1e-161 rlmA 2.1.1.187 Q Methyltransferase domain
MNLHAPDI_02373 1.9e-212 nupG F Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MNLHAPDI_02374 1.2e-22 T Domain of unknown function (DUF4163)
MNLHAPDI_02375 2.7e-48 yxiS
MNLHAPDI_02376 0.0 katE 1.11.1.6, 3.5.1.124 P serves to protect cells from the toxic effects of hydrogen peroxide
MNLHAPDI_02377 6.6e-224 citH C Citrate transporter
MNLHAPDI_02378 3.3e-143 exoK GH16 M licheninase activity
MNLHAPDI_02379 8.3e-151 licT K transcriptional antiterminator
MNLHAPDI_02380 2e-110
MNLHAPDI_02381 5.6e-231 yxiO S COG2270 Permeases of the major facilitator superfamily
MNLHAPDI_02382 5.6e-264 dbpA 3.6.4.13 JKL DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes
MNLHAPDI_02383 7.5e-219 3.2.1.14 GH18 E GDSL-like Lipase/Acylhydrolase
MNLHAPDI_02386 1.6e-48 yxiJ S YxiJ-like protein
MNLHAPDI_02387 1.2e-96 yxiI S Protein of unknown function (DUF2716)
MNLHAPDI_02388 3.8e-81
MNLHAPDI_02389 4.9e-46
MNLHAPDI_02390 3.7e-75 yxiG
MNLHAPDI_02391 6.4e-63
MNLHAPDI_02392 1.7e-84
MNLHAPDI_02393 1.5e-71 yxxG
MNLHAPDI_02394 0.0 wapA M COG3209 Rhs family protein
MNLHAPDI_02395 2.9e-168 yxxF EG EamA-like transporter family
MNLHAPDI_02396 1.1e-72 yxiE T Belongs to the universal stress protein A family
MNLHAPDI_02397 2.5e-280 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
MNLHAPDI_02398 7.6e-311 bglF 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
MNLHAPDI_02399 3.6e-51
MNLHAPDI_02400 2.2e-78 S SMI1 / KNR4 family
MNLHAPDI_02401 0.0 S nuclease activity
MNLHAPDI_02402 3.6e-39 yxiC S Family of unknown function (DUF5344)
MNLHAPDI_02403 2.1e-21 S Domain of unknown function (DUF5082)
MNLHAPDI_02404 1.3e-265 yxiA 3.2.1.99 GH43 G Belongs to the glycosyl hydrolase 43 family
MNLHAPDI_02406 5e-78 hutP K Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization
MNLHAPDI_02407 1.3e-282 hutH 4.3.1.3 E Histidine ammonia-lyase
MNLHAPDI_02408 0.0 hutU 4.2.1.49 E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MNLHAPDI_02409 1.2e-238 hutI 3.5.2.7 Q Imidazolone-5-propionate hydrolase
MNLHAPDI_02410 6.8e-181 hutG 3.5.3.11, 3.5.3.8 E Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide
MNLHAPDI_02411 7.5e-250 lysP E amino acid
MNLHAPDI_02412 1e-232 pdp 2.4.2.2, 2.4.2.4 F phosphorylase
MNLHAPDI_02413 9.8e-206 nupC F Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MNLHAPDI_02414 7.7e-115 deoC 4.1.2.4 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MNLHAPDI_02415 7.9e-174 deoR K COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain
MNLHAPDI_02416 2.2e-151 yxxB S Domain of Unknown Function (DUF1206)
MNLHAPDI_02417 1.9e-195 eutH E Ethanolamine utilisation protein, EutH
MNLHAPDI_02418 6.2e-249 yxeQ S MmgE/PrpD family
MNLHAPDI_02419 5.2e-212 yxeP 3.5.1.47 E hydrolase activity
MNLHAPDI_02420 1.2e-132 yxeO 3.6.3.21 P ABC transporter, ATP-binding protein
MNLHAPDI_02421 2.7e-107 yxeN P COG0765 ABC-type amino acid transport system, permease component
MNLHAPDI_02422 2.5e-144 yxeM M Belongs to the bacterial solute-binding protein 3 family
MNLHAPDI_02423 1.6e-93 yxeL K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
MNLHAPDI_02424 2.8e-254 yxeK C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MNLHAPDI_02426 1.3e-187 yxeI 3.5.1.24 M Linear amide C-N hydrolases, choloylglycine hydrolase family
MNLHAPDI_02427 1.8e-150 yidA S hydrolases of the HAD superfamily
MNLHAPDI_02430 1.3e-20 yxeE
MNLHAPDI_02431 5.6e-16 yxeD
MNLHAPDI_02432 3.2e-68
MNLHAPDI_02433 1.1e-175 fhuD P ABC transporter
MNLHAPDI_02434 3.4e-58 yxeA S Protein of unknown function (DUF1093)
MNLHAPDI_02435 0.0 yxdM V ABC transporter (permease)
MNLHAPDI_02436 2.7e-140 yxdL V ABC transporter, ATP-binding protein
MNLHAPDI_02437 2e-180 T PhoQ Sensor
MNLHAPDI_02438 2.7e-123 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MNLHAPDI_02439 1.2e-160 iolJ 4.1.2.13, 4.1.2.29 F Produces dihydroxyacetone phosphate (DHAP or glycerone phosphate) and malonic semialdehyde (MSA or 3-oxopropanoate) from 6-phospho-5-dehydro-2-deoxy-D-gluconate (DKGP)
MNLHAPDI_02440 5.6e-139 iolI 5.3.99.11 G Involved in the reversible interconverion of 2-keto-myo- inositol (2KMI, inosose or 2,4,6 3,5-pentahydroxycyclohexanone) to 1-keto-D-chiro-inositol (1KDCI or 2,3,5 4,6- pentahydroxycyclohexanone)
MNLHAPDI_02441 8.6e-167 iolH G Xylose isomerase-like TIM barrel
MNLHAPDI_02442 1.8e-195 iolG 1.1.1.18, 1.1.1.369 S Involved in the oxidation of myo-inositol (MI) and D- chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively
MNLHAPDI_02443 9.6e-234 iolF EGP Major facilitator Superfamily
MNLHAPDI_02444 2.1e-176 iolE 4.2.1.44 G Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol)
MNLHAPDI_02445 0.0 iolD 3.7.1.22 E Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG)
MNLHAPDI_02446 7.1e-178 iolC 2.7.1.92 G Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D- gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5- dehydro-2-deoxy-D-gluconate (DKGP)
MNLHAPDI_02447 1.1e-155 iolB 5.3.1.30 G Involved in the isomerization of 5-deoxy-glucuronate (5DG) to 5-dehydro-2-deoxy-D-gluconate (DKG or 2-deoxy-5-keto-D- gluconate)
MNLHAPDI_02448 1.4e-281 iolA 1.2.1.18, 1.2.1.27 C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
MNLHAPDI_02449 3.3e-138 iolR K COG1349 Transcriptional regulators of sugar metabolism
MNLHAPDI_02450 8.3e-176 iolS C Aldo keto reductase
MNLHAPDI_02452 8.3e-48 yxcD S Protein of unknown function (DUF2653)
MNLHAPDI_02453 2.8e-244 csbC EGP Major facilitator Superfamily
MNLHAPDI_02454 0.0 htpG O Molecular chaperone. Has ATPase activity
MNLHAPDI_02456 2.4e-150 IQ Enoyl-(Acyl carrier protein) reductase
MNLHAPDI_02457 2.7e-208 yxbF K Bacterial regulatory proteins, tetR family
MNLHAPDI_02458 1.3e-246 alkH 1.2.1.3 C Belongs to the aldehyde dehydrogenase family
MNLHAPDI_02459 4e-12 yxaI S membrane protein domain
MNLHAPDI_02460 9.9e-92 S PQQ-like domain
MNLHAPDI_02461 7.2e-60 S Family of unknown function (DUF5391)
MNLHAPDI_02462 1.4e-75 yxaI S membrane protein domain
MNLHAPDI_02463 1.5e-222 P Protein of unknown function (DUF418)
MNLHAPDI_02464 2.7e-196 yxaG 1.13.11.24 S AraC-like ligand binding domain
MNLHAPDI_02465 1.6e-100 yxaF K Transcriptional regulator
MNLHAPDI_02466 5.8e-197 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
MNLHAPDI_02467 4.4e-71 yxaD K helix_turn_helix multiple antibiotic resistance protein
MNLHAPDI_02468 8.9e-50 S LrgA family
MNLHAPDI_02469 1.3e-117 yxaC M effector of murein hydrolase
MNLHAPDI_02470 8.3e-193 yxaB GM Polysaccharide pyruvyl transferase
MNLHAPDI_02471 6.6e-207 glxK 2.7.1.165 G Belongs to the glycerate kinase type-1 family
MNLHAPDI_02472 2.8e-126 gntR K transcriptional
MNLHAPDI_02473 2.8e-301 gntK 2.7.1.12, 2.7.1.17, 2.7.1.5 G Belongs to the FGGY kinase family
MNLHAPDI_02474 1e-230 gntP EG COG2610 H gluconate symporter and related permeases
MNLHAPDI_02475 1.8e-270 gnd 1.1.1.343, 1.1.1.44 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MNLHAPDI_02476 2.1e-105 ahpC 1.11.1.15 O Alkyl hydroperoxide reductase
MNLHAPDI_02477 1.9e-286 ahpF O Alkyl hydroperoxide reductase
MNLHAPDI_02478 6.4e-292 bglA 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
MNLHAPDI_02479 2.3e-34 2.7.1.199 G phosphoenolpyruvate-dependent sugar phosphotransferase system
MNLHAPDI_02480 3e-125 yydK K Transcriptional regulator
MNLHAPDI_02481 7.1e-11
MNLHAPDI_02482 1.6e-118 S ABC-2 family transporter protein
MNLHAPDI_02483 1.6e-109 prrC P ABC transporter
MNLHAPDI_02484 1.4e-133 yydH O Peptidase M50
MNLHAPDI_02485 7.7e-185 S Radical SAM superfamily
MNLHAPDI_02486 2.3e-11
MNLHAPDI_02487 0.0 fbp 3.1.3.11 G Firmicute fructose-1,6-bisphosphatase
MNLHAPDI_02489 6.8e-81 rlmH 2.1.1.177 J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MNLHAPDI_02490 1.1e-09 S YyzF-like protein
MNLHAPDI_02491 6.5e-64
MNLHAPDI_02492 3.3e-233 fdhA 1.1.1.1, 1.1.1.14, 1.1.1.284, 1.2.1.46 E COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
MNLHAPDI_02494 9.7e-31 yycQ S Protein of unknown function (DUF2651)
MNLHAPDI_02495 1.7e-202 yycP
MNLHAPDI_02496 2.9e-131 yycO S Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
MNLHAPDI_02497 3.4e-85 yycN 2.3.1.128 K Acetyltransferase
MNLHAPDI_02498 5e-188 S aspartate phosphatase
MNLHAPDI_02500 2.3e-167 rocF 3.5.3.1, 3.5.3.11 E Belongs to the arginase family
MNLHAPDI_02501 9.7e-261 rocE E amino acid
MNLHAPDI_02502 4.3e-233 rocD 2.6.1.11, 2.6.1.13, 2.6.1.17 E Catalyzes the interconversion of ornithine to glutamate semialdehyde
MNLHAPDI_02504 9.9e-258 rocR KT COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains
MNLHAPDI_02505 1e-172 phoR3 2.7.13.3 T COG0642 Signal transduction histidine kinase
MNLHAPDI_02506 1.5e-94 K PFAM response regulator receiver
MNLHAPDI_02507 1.2e-73 S Peptidase propeptide and YPEB domain
MNLHAPDI_02508 1.7e-34 S Peptidase propeptide and YPEB domain
MNLHAPDI_02509 8.7e-218 htrA 3.4.21.107 O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MNLHAPDI_02510 1.9e-149 vicX 3.1.26.11 S COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I
MNLHAPDI_02511 1.8e-153 yycI S protein conserved in bacteria
MNLHAPDI_02512 1.2e-258 yycH S protein conserved in bacteria
MNLHAPDI_02513 0.0 vicK 2.7.13.3 T Histidine kinase
MNLHAPDI_02514 1.1e-132 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MNLHAPDI_02519 3e-248 purA 6.3.4.4 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MNLHAPDI_02520 1.5e-76 yycE 3.4.21.26, 5.3.1.24 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
MNLHAPDI_02521 3e-251 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
MNLHAPDI_02522 1.9e-29 yycD S Uncharacterized protein conserved in bacteria (DUF2188)
MNLHAPDI_02524 8.4e-221 yeaN P COG2807 Cyanate permease
MNLHAPDI_02525 0.0 yycA M COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MNLHAPDI_02526 2.2e-73 rplI J binds to the 23S rRNA
MNLHAPDI_02527 0.0 yybT T signaling protein consisting of a modified GGDEF domain and a DHH domain
MNLHAPDI_02528 8.3e-160 yybS S membrane
MNLHAPDI_02530 3.3e-83 cotF M Spore coat protein
MNLHAPDI_02531 7.5e-67 ydeP3 K Transcriptional regulator
MNLHAPDI_02532 1.1e-164 ppaC 3.6.1.1 C Inorganic pyrophosphatase
MNLHAPDI_02533 1.5e-58
MNLHAPDI_02535 1.8e-240 yybO G COG0477 Permeases of the major facilitator superfamily
MNLHAPDI_02536 9.7e-111 K TipAS antibiotic-recognition domain
MNLHAPDI_02537 4.8e-124
MNLHAPDI_02538 6.5e-66 yybH S SnoaL-like domain
MNLHAPDI_02539 3e-124 yybG S Pentapeptide repeat-containing protein
MNLHAPDI_02540 4.6e-219 ynfM EGP Major facilitator Superfamily
MNLHAPDI_02541 5.8e-163 yybE K Transcriptional regulator
MNLHAPDI_02542 9.4e-77 yjcF S Acetyltransferase (GNAT) domain
MNLHAPDI_02543 1.1e-56 yybC
MNLHAPDI_02544 2.8e-125 S Metallo-beta-lactamase superfamily
MNLHAPDI_02545 5.6e-77 yybA 2.3.1.57 K transcriptional
MNLHAPDI_02546 2.9e-70 yjcF S Acetyltransferase (GNAT) domain
MNLHAPDI_02547 3.2e-96 yyaS S Membrane
MNLHAPDI_02548 2.1e-91 yyaR K Acetyltransferase (GNAT) domain
MNLHAPDI_02549 3.5e-66 yyaQ S YjbR
MNLHAPDI_02550 1.4e-104 yyaP 1.5.1.3 H RibD C-terminal domain
MNLHAPDI_02551 1.1e-243 tetL EGP Major facilitator Superfamily
MNLHAPDI_02553 7.5e-10 S Putative amidase domain
MNLHAPDI_02554 5.1e-61 yyaN K MerR HTH family regulatory protein
MNLHAPDI_02555 4.4e-161 yyaM EG EamA-like transporter family
MNLHAPDI_02556 3.4e-21 yyaL O COG1331 Highly conserved protein containing a thioredoxin domain
MNLHAPDI_02557 9.7e-67 yrhP E LysE type translocator
MNLHAPDI_02558 4.4e-24 yyaL O COG1331 Highly conserved protein containing a thioredoxin domain
MNLHAPDI_02559 0.0 yyaL O COG1331 Highly conserved protein containing a thioredoxin domain
MNLHAPDI_02560 8e-168 yyaK S CAAX protease self-immunity
MNLHAPDI_02561 7.9e-244 EGP Major facilitator superfamily
MNLHAPDI_02562 2.8e-94 maa 2.3.1.79 S Bacterial transferase hexapeptide (six repeats)
MNLHAPDI_02563 1.9e-65 yyaH 4.4.1.5 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
MNLHAPDI_02564 1.5e-177 ccpB 3.5.1.4, 5.1.1.1 K Transcriptional regulator
MNLHAPDI_02565 1.7e-142 xth 3.1.11.2 L exodeoxyribonuclease III
MNLHAPDI_02566 5.1e-37 rpsR J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MNLHAPDI_02567 2.9e-69 ssb L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
MNLHAPDI_02568 4.3e-46 rpsF J Binds together with S18 to 16S ribosomal RNA
MNLHAPDI_02569 4e-201 ychF J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
MNLHAPDI_02570 0.0 yyaE C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MNLHAPDI_02571 2.3e-33 yyzM S protein conserved in bacteria
MNLHAPDI_02572 8.1e-177 yyaD S Membrane
MNLHAPDI_02573 2.1e-111 yyaC S Sporulation protein YyaC
MNLHAPDI_02574 3.9e-148 spo0J K Belongs to the ParB family
MNLHAPDI_02575 2.2e-134 soj D COG1192 ATPases involved in chromosome partitioning
MNLHAPDI_02576 1.1e-72 S Bacterial PH domain
MNLHAPDI_02577 5.5e-150 noc D Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage
MNLHAPDI_02578 1.4e-130 rsmG 2.1.1.170 J Specifically methylates the N7 position of guanine in position 535 of 16S rRNA
MNLHAPDI_02579 0.0 gidA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
MNLHAPDI_02580 1.1e-248 mnmE S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MNLHAPDI_02581 6.5e-108 jag S single-stranded nucleic acid binding R3H
MNLHAPDI_02582 1.7e-118 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
MNLHAPDI_02583 3e-54 rnpA 3.1.26.5 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
MNLHAPDI_02584 6e-252 dnaA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MNLHAPDI_02585 6.1e-205 dnaN 2.7.7.7 L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
MNLHAPDI_02586 2.4e-33 yaaA S S4 domain
MNLHAPDI_02587 1.4e-206 recF L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MNLHAPDI_02588 1.8e-37 yaaB S Domain of unknown function (DUF370)
MNLHAPDI_02589 0.0 gyrB 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MNLHAPDI_02590 0.0 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MNLHAPDI_02591 3.4e-39 S COG NOG14552 non supervised orthologous group
MNLHAPDI_02594 2.7e-182 yaaC S YaaC-like Protein
MNLHAPDI_02595 1.8e-273 guaB 1.1.1.205 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
MNLHAPDI_02596 5.2e-248 dacA 3.4.16.4 M Belongs to the peptidase S11 family
MNLHAPDI_02597 2.2e-157 pdxS 4.3.3.6 H Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MNLHAPDI_02598 8e-108 pdxT 4.3.3.6 H Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MNLHAPDI_02599 4.3e-207 serS 6.1.1.11 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MNLHAPDI_02600 1.3e-09
MNLHAPDI_02601 2.2e-122 dck 2.7.1.113, 2.7.1.74, 2.7.1.76 F Deoxycytidine kinase
MNLHAPDI_02602 3.2e-115 dgk 2.7.1.113, 2.7.1.74, 2.7.1.76 F Deoxyguanosine kinase
MNLHAPDI_02603 5.6e-215 yaaH M Glycoside Hydrolase Family
MNLHAPDI_02604 2.4e-98 yaaI Q COG1335 Amidases related to nicotinamidase
MNLHAPDI_02605 1e-84 tadA 3.5.4.1, 3.5.4.3, 3.5.4.33 FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
MNLHAPDI_02606 0.0 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MNLHAPDI_02607 5.3e-37 yaaK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MNLHAPDI_02608 3.9e-110 recR L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MNLHAPDI_02609 7.9e-32 yaaL S Protein of unknown function (DUF2508)
MNLHAPDI_02610 3.7e-36 bofA S Sigma-K factor-processing regulatory protein BofA
MNLHAPDI_02611 3.4e-39 S COG NOG14552 non supervised orthologous group
MNLHAPDI_02614 3.4e-31 csfB S Inhibitor of sigma-G Gin
MNLHAPDI_02615 4.7e-103 xpaC S 5-bromo-4-chloroindolyl phosphate hydrolysis protein
MNLHAPDI_02616 4.9e-202 yaaN P Belongs to the TelA family
MNLHAPDI_02617 6.6e-273 adiA 4.1.1.17, 4.1.1.18, 4.1.1.19 E Orn Lys Arg decarboxylase
MNLHAPDI_02618 5.3e-113 tmk 2.7.4.9 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MNLHAPDI_02619 2.2e-54 yaaQ S protein conserved in bacteria
MNLHAPDI_02620 1.5e-71 yaaR S protein conserved in bacteria
MNLHAPDI_02621 1.1e-181 holB 2.7.7.7 L DNA polymerase III
MNLHAPDI_02622 6.1e-146 yaaT S stage 0 sporulation protein
MNLHAPDI_02623 4.8e-31 yabA L Involved in initiation control of chromosome replication
MNLHAPDI_02624 2.5e-138 yabB 2.1.1.223 S Conserved hypothetical protein 95
MNLHAPDI_02625 2.8e-48 yazA L endonuclease containing a URI domain
MNLHAPDI_02626 1e-151 rsmI 2.1.1.198 H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MNLHAPDI_02627 8.8e-44 abrB K COG2002 Regulators of stationary sporulation gene expression
MNLHAPDI_02628 0.0 metG 6.1.1.10, 6.1.1.20 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MNLHAPDI_02629 1.2e-143 tatD L hydrolase, TatD
MNLHAPDI_02630 4.3e-194 rpfB GH23 T protein conserved in bacteria
MNLHAPDI_02631 8.4e-99 rnmV 3.1.26.8 J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MNLHAPDI_02632 2.4e-156 ksgA 2.1.1.182 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
MNLHAPDI_02633 1.6e-136 yabG S peptidase
MNLHAPDI_02634 7.8e-39 veg S protein conserved in bacteria
MNLHAPDI_02635 8.3e-27 sspF S DNA topological change
MNLHAPDI_02636 2.1e-160 ispE 2.1.1.182, 2.7.1.148 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MNLHAPDI_02637 2.6e-152 purR 2.4.2.22, 2.4.2.7 F pur operon repressor
MNLHAPDI_02638 3.8e-63 yabJ 3.5.99.10 J translation initiation inhibitor, yjgF family
MNLHAPDI_02639 4.6e-48 spoVG D Essential for sporulation. Interferes with or is a negative regulator of the pathway leading to asymmetric septation
MNLHAPDI_02640 1.1e-229 glmU 2.3.1.157, 2.7.7.23 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MNLHAPDI_02641 9.4e-175 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MNLHAPDI_02642 3.9e-97 ctc J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MNLHAPDI_02643 2.3e-104 pth 3.1.1.29 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
MNLHAPDI_02644 2.4e-39 yabK S Peptide ABC transporter permease
MNLHAPDI_02645 0.0 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MNLHAPDI_02646 1.5e-92 spoVT K stage V sporulation protein
MNLHAPDI_02647 1.3e-282 yabM S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
MNLHAPDI_02648 3e-244 mazG 3.6.1.66, 3.6.1.9 S COG3956 Protein containing tetrapyrrole methyltransferase domain and MazG-like
MNLHAPDI_02649 1.1e-37 yabO J COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
MNLHAPDI_02650 1.5e-49 yabP S Sporulation protein YabP
MNLHAPDI_02651 2.5e-107 yabQ S spore cortex biosynthesis protein
MNLHAPDI_02652 1.1e-44 divIC D Septum formation initiator
MNLHAPDI_02653 8.5e-58 yabR J RNA binding protein (contains ribosomal protein S1 domain)
MNLHAPDI_02656 0.0 spoIIE 3.1.3.16, 3.1.3.3 KT stage II sporulation protein E
MNLHAPDI_02657 1.5e-124 yabS S protein containing a von Willebrand factor type A (vWA) domain
MNLHAPDI_02658 1.1e-184 KLT serine threonine protein kinase
MNLHAPDI_02659 6.5e-273 tilS 2.4.2.8, 6.3.4.19 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
MNLHAPDI_02660 7.9e-94 hpt 2.4.2.8, 6.3.4.19 F Belongs to the purine pyrimidine phosphoribosyltransferase family
MNLHAPDI_02661 0.0 ftsH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MNLHAPDI_02662 1.5e-146 coaX 2.7.1.33 F Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MNLHAPDI_02663 2.9e-162 hslO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MNLHAPDI_02664 1.3e-151 yacD 5.2.1.8 O peptidyl-prolyl isomerase
MNLHAPDI_02665 5.7e-169 cysK 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
MNLHAPDI_02666 2.2e-268 pabB 2.6.1.85 EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MNLHAPDI_02667 4.3e-106 pabA 2.6.1.85, 4.1.3.27 EH Anthranilate synthase
MNLHAPDI_02668 1.6e-168 pabC 2.6.1.42, 4.1.3.38 EH 4-amino-4-deoxychorismate lyase
MNLHAPDI_02669 2.6e-160 folP 2.5.1.15, 2.7.6.3 H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MNLHAPDI_02670 5.9e-61 folB 1.13.11.81, 2.5.1.15, 2.7.6.3, 4.1.2.25, 5.1.99.8 H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MNLHAPDI_02671 1.8e-87 folK 1.13.11.81, 2.5.1.15, 2.7.6.3, 3.5.4.16, 4.1.2.25, 5.1.99.8 H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MNLHAPDI_02672 4.1e-30 yazB K transcriptional
MNLHAPDI_02673 3.7e-190 dus J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MNLHAPDI_02674 1.3e-287 lysS 6.1.1.6 J Belongs to the class-II aminoacyl-tRNA synthetase family
MNLHAPDI_02675 3.4e-39 S COG NOG14552 non supervised orthologous group
MNLHAPDI_02680 2e-08
MNLHAPDI_02685 3.4e-39 S COG NOG14552 non supervised orthologous group
MNLHAPDI_02686 2.9e-76 ctsR K Belongs to the CtsR family
MNLHAPDI_02687 4.7e-47 mcsA 2.7.14.1 S protein with conserved CXXC pairs
MNLHAPDI_02688 6.1e-202 mcsB 2.7.14.1, 2.7.3.2, 2.7.3.3 E Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity
MNLHAPDI_02689 0.0 clpC O Belongs to the ClpA ClpB family
MNLHAPDI_02690 9.6e-256 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MNLHAPDI_02691 1.3e-196 disA 2.7.7.85 L Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
MNLHAPDI_02692 2.7e-197 yacL S COG4956 Integral membrane protein (PIN domain superfamily)
MNLHAPDI_02693 3.8e-125 ispD 2.7.7.60, 4.6.1.12 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)
MNLHAPDI_02694 3.1e-86 ispF 2.1.1.228, 2.7.7.60, 4.6.1.12 I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)
MNLHAPDI_02695 1.9e-280 gltX 6.1.1.17, 6.1.1.24 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MNLHAPDI_02696 7.2e-118 cysE 2.3.1.30 E Serine acetyltransferase
MNLHAPDI_02697 4.9e-273 cysS 6.1.1.16, 6.3.1.13 J Belongs to the class-I aminoacyl-tRNA synthetase family
MNLHAPDI_02698 1e-72 mrnC J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MNLHAPDI_02699 1.2e-135 trmH 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MNLHAPDI_02700 1.2e-88 yacP S RNA-binding protein containing a PIN domain
MNLHAPDI_02701 4.4e-115 sigH K Belongs to the sigma-70 factor family
MNLHAPDI_02702 1e-21 secE U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
MNLHAPDI_02703 5.2e-96 nusG K Participates in transcription elongation, termination and antitermination
MNLHAPDI_02704 2.8e-70 rplK J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MNLHAPDI_02705 1.1e-124 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
MNLHAPDI_02706 5.1e-79 rplJ J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MNLHAPDI_02707 1.3e-42 rplL J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
MNLHAPDI_02708 8.2e-108 rsmC 2.1.1.172 J Methyltransferase
MNLHAPDI_02709 0.0 rpoB 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MNLHAPDI_02710 0.0 rpoC 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MNLHAPDI_02711 8e-33 ybxF J Belongs to the eukaryotic ribosomal protein eL8 family
MNLHAPDI_02712 8.5e-72 rpsL J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MNLHAPDI_02713 6e-82 rpsG J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
MNLHAPDI_02714 0.0 fusA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MNLHAPDI_02715 2.5e-225 tuf J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MNLHAPDI_02716 9.1e-186 ybaC 3.4.11.5 S Alpha/beta hydrolase family
MNLHAPDI_02717 7.5e-49 rpsJ J Involved in the binding of tRNA to the ribosomes
MNLHAPDI_02718 6.3e-111 rplC J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MNLHAPDI_02719 3e-105 rplD J Forms part of the polypeptide exit tunnel
MNLHAPDI_02720 1.2e-43 rplW J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
MNLHAPDI_02721 1.5e-155 rplB J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MNLHAPDI_02722 3.7e-47 rpsS J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MNLHAPDI_02723 4.3e-53 rplV J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MNLHAPDI_02724 6.2e-117 rpsC J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MNLHAPDI_02725 1.3e-75 rplP J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MNLHAPDI_02726 1.7e-25 rpmC J Belongs to the universal ribosomal protein uL29 family
MNLHAPDI_02727 3.5e-39 rpsQ J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MNLHAPDI_02728 3.9e-60 rplN J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MNLHAPDI_02729 6.2e-51 rplX J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MNLHAPDI_02730 4.6e-94 rplE J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MNLHAPDI_02731 3.4e-28 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MNLHAPDI_02732 3.9e-66 rpsH J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MNLHAPDI_02733 1.3e-93 rplF J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MNLHAPDI_02734 4e-57 rplR J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MNLHAPDI_02735 3.1e-84 rpsE J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MNLHAPDI_02736 1.9e-23 rpmD J Ribosomal protein L30
MNLHAPDI_02737 1.8e-72 rplO J binds to the 23S rRNA
MNLHAPDI_02738 2.1e-233 secY U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
MNLHAPDI_02739 5.7e-123 adk 2.7.4.3 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
MNLHAPDI_02740 3.7e-142 map 3.4.11.18 E Methionine aminopeptidase
MNLHAPDI_02741 1.1e-33 infA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MNLHAPDI_02742 4.2e-13 rpmJ J Belongs to the bacterial ribosomal protein bL36 family
MNLHAPDI_02743 3.1e-57 rpsM J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MNLHAPDI_02744 2.1e-64 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MNLHAPDI_02745 3.1e-170 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MNLHAPDI_02746 3.6e-58 rplQ J Ribosomal protein L17
MNLHAPDI_02747 5.1e-156 cbiO P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MNLHAPDI_02748 1.7e-154 ecfA2 3.6.3.55 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MNLHAPDI_02749 4.7e-119 ecfT P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MNLHAPDI_02750 8.2e-142 truA 5.4.99.12 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
MNLHAPDI_02751 6.4e-78 rplM J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MNLHAPDI_02752 4.7e-64 rpsI J Belongs to the universal ribosomal protein uS9 family
MNLHAPDI_02753 2.4e-144 ybaJ Q Methyltransferase domain
MNLHAPDI_02754 9.7e-66 ybaK S Protein of unknown function (DUF2521)
MNLHAPDI_02755 2.5e-132 cwlD 3.5.1.28 M n-acetylmuramoyl-L-alanine amidase
MNLHAPDI_02756 1.4e-198 mrp D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP
MNLHAPDI_02757 1.2e-84 gerD
MNLHAPDI_02758 1.3e-102 kbaA 2.7.8.43 S Involved in the activation of the KinB signaling pathway of sporulation
MNLHAPDI_02759 1.2e-140 pdaB 3.5.1.104 G Polysaccharide deacetylase
MNLHAPDI_02760 3.4e-39 S COG NOG14552 non supervised orthologous group
MNLHAPDI_02763 2e-08
MNLHAPDI_02767 3.4e-39 S COG NOG14552 non supervised orthologous group
MNLHAPDI_02768 3.4e-39 S COG NOG14552 non supervised orthologous group
MNLHAPDI_02769 4.6e-250 ybaR P COG0659 Sulfate permease and related transporters (MFS superfamily)
MNLHAPDI_02771 1.2e-161 ybaS 1.1.1.58 S Na -dependent transporter
MNLHAPDI_02772 2.2e-142 ybbA S Putative esterase
MNLHAPDI_02773 3e-179 feuC P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MNLHAPDI_02774 1.1e-176 feuB P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MNLHAPDI_02775 2.7e-166 feuA P Iron-uptake system-binding protein
MNLHAPDI_02776 5.4e-308 ybbB K COG2207 AraC-type DNA-binding domain-containing proteins
MNLHAPDI_02777 4.4e-241 ybbC 3.2.1.52 S protein conserved in bacteria
MNLHAPDI_02778 0.0 ybbD 3.2.1.52 G Belongs to the glycosyl hydrolase 3 family
MNLHAPDI_02779 4e-256 yfeW 3.4.16.4 V Belongs to the UPF0214 family
MNLHAPDI_02780 9.8e-234 ybbF 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
MNLHAPDI_02781 1.1e-150 ybbH K transcriptional
MNLHAPDI_02782 2.1e-163 murQ 4.2.1.126 G Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
MNLHAPDI_02783 6.4e-87 ybbJ J acetyltransferase
MNLHAPDI_02784 3.9e-78 ybbK 2.4.2.1, 6.3.2.4 S Protein of unknown function (DUF523)
MNLHAPDI_02790 2.5e-98 sigW K Belongs to the sigma-70 factor family. ECF subfamily
MNLHAPDI_02791 3.7e-103 rsiW K Is the anti-sigma factor for SigW. The presence of RsiW leads to the inactivation of SigW, and its proteolytic destruction to sigma-W activation
MNLHAPDI_02792 2.7e-146 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MNLHAPDI_02793 3e-225 ybbR S protein conserved in bacteria
MNLHAPDI_02794 7.9e-252 glmM 5.4.2.10 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MNLHAPDI_02795 0.0 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
MNLHAPDI_02796 2.1e-176 alkA 3.2.2.21 L COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
MNLHAPDI_02797 1.7e-119 adaA 3.2.2.21 K Transcriptional regulator
MNLHAPDI_02798 1.1e-98 ogt 2.1.1.63, 3.2.2.21 L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MNLHAPDI_02799 5.3e-273 ndhF 1.6.5.3 CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit
MNLHAPDI_02800 0.0 ybcC S Belongs to the UPF0753 family
MNLHAPDI_02801 1.1e-89 can 4.2.1.1 P carbonic anhydrase
MNLHAPDI_02803 1.9e-46
MNLHAPDI_02804 4.7e-61 ybcI S Uncharacterized conserved protein (DUF2294)
MNLHAPDI_02805 5.1e-50 ybzH K Helix-turn-helix domain
MNLHAPDI_02806 4.2e-201 ybcL EGP Major facilitator Superfamily
MNLHAPDI_02808 9.1e-239 J 4Fe-4S single cluster domain
MNLHAPDI_02809 1.6e-277 V CAAX protease self-immunity
MNLHAPDI_02810 1.9e-135 skfE V ABC transporter
MNLHAPDI_02811 4e-248 skfF S ABC transporter
MNLHAPDI_02812 7.8e-91 C HEAT repeats
MNLHAPDI_02813 9.6e-79 txn CO Thioredoxin-like
MNLHAPDI_02814 1.4e-181 S hydrolases or acyltransferases (alpha beta hydrolase superfamily)
MNLHAPDI_02815 3.8e-122 T Transcriptional regulatory protein, C terminal
MNLHAPDI_02816 1.8e-168 T His Kinase A (phospho-acceptor) domain
MNLHAPDI_02818 3.9e-139 KLT Protein tyrosine kinase
MNLHAPDI_02819 1.1e-150 ybdN
MNLHAPDI_02820 1.5e-214 ybdO S Domain of unknown function (DUF4885)
MNLHAPDI_02821 1.5e-258 yifK E COG1113 Gamma-aminobutyrate permease and related permeases
MNLHAPDI_02822 3.7e-38 csgA S Sigma-G-dependent sporulation-specific SASP protein
MNLHAPDI_02823 4.9e-30 ybxH S Family of unknown function (DUF5370)
MNLHAPDI_02824 1.8e-150 ybxI 3.5.2.6 V beta-lactamase
MNLHAPDI_02825 7.6e-241 cypC 1.11.2.4, 1.14.14.1 Q Cytochrome P450
MNLHAPDI_02826 4.9e-41 ybyB
MNLHAPDI_02827 8.8e-290 ybeC E amino acid
MNLHAPDI_02828 5.6e-166 glpQ 3.1.4.46 C glycerophosphoryl diester phosphodiesterase
MNLHAPDI_02829 7.3e-258 glpT G -transporter
MNLHAPDI_02830 2.9e-35 S Protein of unknown function (DUF2651)
MNLHAPDI_02831 1.6e-171 ybfA 3.4.15.5 K FR47-like protein
MNLHAPDI_02832 2.2e-224 ybfB G COG0477 Permeases of the major facilitator superfamily
MNLHAPDI_02834 0.0 ybfG 3.2.1.132 M Domain of unknown function (DUF1906)
MNLHAPDI_02835 2e-161 ybfH EG EamA-like transporter family
MNLHAPDI_02836 2.3e-145 msmR K AraC-like ligand binding domain
MNLHAPDI_02837 2.1e-213 purT 2.1.2.2 F Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
MNLHAPDI_02838 7.6e-177 mpr 3.4.21.19 M Belongs to the peptidase S1B family
MNLHAPDI_02840 2.1e-168 S Alpha/beta hydrolase family
MNLHAPDI_02841 9.2e-95 pssA 2.7.8.8 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MNLHAPDI_02842 2.7e-85 ybfM S SNARE associated Golgi protein
MNLHAPDI_02843 5.6e-149 psd 4.1.1.65 I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)
MNLHAPDI_02844 4.6e-45 ybfN
MNLHAPDI_02845 3.4e-255 S Erythromycin esterase
MNLHAPDI_02846 6.7e-167 ybfP K Transcriptional regulator
MNLHAPDI_02847 3.9e-192 yceA S Belongs to the UPF0176 family
MNLHAPDI_02848 6.4e-216 gltP C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
MNLHAPDI_02849 0.0 ptsG 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
MNLHAPDI_02850 2.1e-137 nagB 3.1.1.31, 3.5.99.6 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
MNLHAPDI_02851 4.9e-128 K UTRA
MNLHAPDI_02853 4.6e-202 ilvE 2.6.1.42 E Branched-chain amino acid aminotransferase
MNLHAPDI_02854 2e-261 mmuP E amino acid
MNLHAPDI_02855 9.3e-183 mmuM 1.5.1.20, 2.1.1.10 H homocysteine
MNLHAPDI_02856 2.3e-257 agcS E Sodium alanine symporter
MNLHAPDI_02857 2.9e-187 glsA 3.5.1.2 E Belongs to the glutaminase family
MNLHAPDI_02858 4.2e-229 phoQ 2.7.13.3 T Histidine kinase
MNLHAPDI_02859 9e-170 glnL T Regulator
MNLHAPDI_02860 2.7e-174 kdgD 4.2.1.41 EM 5-dehydro-4-deoxyglucarate dehydratase activity
MNLHAPDI_02861 3.7e-274 ycbD C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
MNLHAPDI_02862 1.6e-255 gudP G COG0477 Permeases of the major facilitator superfamily
MNLHAPDI_02863 3.6e-268 gudD 4.2.1.40 M Belongs to the mandelate racemase muconate lactonizing enzyme family
MNLHAPDI_02864 2.1e-123 ycbG K FCD
MNLHAPDI_02865 7e-297 garD 4.2.1.42, 4.2.1.7 G Altronate
MNLHAPDI_02866 4.8e-176 ycbJ S Macrolide 2'-phosphotransferase
MNLHAPDI_02867 4.4e-24 rtpA K Tryptophan RNA-binding attenuator protein inhibitory protein
MNLHAPDI_02868 7.3e-172 eamA1 EG spore germination
MNLHAPDI_02869 1.7e-125 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MNLHAPDI_02870 1.5e-169 T PhoQ Sensor
MNLHAPDI_02871 4.1e-167 ycbN V ABC transporter, ATP-binding protein
MNLHAPDI_02872 2.1e-115 S ABC-2 family transporter protein
MNLHAPDI_02873 8.2e-53 ycbP S Protein of unknown function (DUF2512)
MNLHAPDI_02874 1.3e-78 sleB 3.5.1.28 M Cell wall
MNLHAPDI_02875 6.6e-136 ycbR T vWA found in TerF C terminus
MNLHAPDI_02876 0.0 phoD 3.1.3.1 P COG3540 Phosphodiesterase alkaline phosphatase D
MNLHAPDI_02877 5e-28 tatA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
MNLHAPDI_02878 2.6e-124 tatC U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MNLHAPDI_02879 4.5e-120 pcp 3.4.19.3 O Removes 5-oxoproline from various penultimate amino acid residues except L-proline
MNLHAPDI_02880 5.2e-201 ycbU E Selenocysteine lyase
MNLHAPDI_02881 5.8e-229 lmrB EGP the major facilitator superfamily
MNLHAPDI_02882 1.6e-100 yxaF K Transcriptional regulator
MNLHAPDI_02883 1.8e-201 ansB 3.5.1.1 EJ COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D
MNLHAPDI_02884 5.6e-115 lip 3.1.1.3 S acetyltransferases and hydrolases with the alpha beta hydrolase fold
MNLHAPDI_02885 2e-59 S RDD family
MNLHAPDI_02886 9.5e-200 yccF K DNA-templated transcriptional preinitiation complex assembly
MNLHAPDI_02887 8.9e-157 2.7.13.3 T GHKL domain
MNLHAPDI_02888 1.2e-126 lytR_2 T LytTr DNA-binding domain
MNLHAPDI_02889 4.1e-133 natA 3.6.3.7 CP ATPases associated with a variety of cellular activities
MNLHAPDI_02890 2.7e-200 natB CP ABC-2 family transporter protein
MNLHAPDI_02891 1.7e-22 yccK C Aldo keto reductase
MNLHAPDI_02892 1e-142 yccK C Aldo keto reductase
MNLHAPDI_02893 6.6e-177 ycdA S Domain of unknown function (DUF5105)
MNLHAPDI_02894 4.2e-272 ycdB K Belongs to the sigma-70 factor family. ECF subfamily
MNLHAPDI_02895 1.5e-259 ycdC K Belongs to the sigma-70 factor family. ECF subfamily
MNLHAPDI_02896 1.7e-95 cwlK M D-alanyl-D-alanine carboxypeptidase
MNLHAPDI_02897 5.5e-174 S response regulator aspartate phosphatase
MNLHAPDI_02898 4.7e-140 IQ Enoyl-(Acyl carrier protein) reductase
MNLHAPDI_02899 0.0 ycdG 3.2.1.10 GH13 G COG0366 Glycosidases
MNLHAPDI_02900 6.6e-168 adcA P Belongs to the bacterial solute-binding protein 9 family
MNLHAPDI_02901 2.5e-132 adcC P 'COG1121 ABC-type Mn Zn transport systems, ATPase component'
MNLHAPDI_02902 1.7e-135 adcB P COG1108 ABC-type Mn2 Zn2 transport systems, permease components
MNLHAPDI_02903 5.4e-189 yceB C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MNLHAPDI_02904 3.9e-110 yceC 3.5.4.33 T proteins involved in stress response, homologs of TerZ and
MNLHAPDI_02905 2.8e-105 yceD T proteins involved in stress response, homologs of TerZ and
MNLHAPDI_02906 4.6e-108 yceE T proteins involved in stress response, homologs of TerZ and
MNLHAPDI_02907 6.3e-137 terC P Protein of unknown function (DUF475)
MNLHAPDI_02908 0.0 yceG S Putative component of 'biosynthetic module'
MNLHAPDI_02909 2e-192 yceH P Belongs to the TelA family
MNLHAPDI_02910 1e-218 naiP P Uncharacterised MFS-type transporter YbfB
MNLHAPDI_02911 1.9e-209 yceJ EGP Uncharacterised MFS-type transporter YbfB
MNLHAPDI_02912 1.6e-45 K helix_turn_helix, Arsenical Resistance Operon Repressor
MNLHAPDI_02913 2.2e-227 proV 3.6.3.32 E glycine betaine
MNLHAPDI_02914 1.3e-127 opuAB P glycine betaine
MNLHAPDI_02915 5.3e-164 opuAC E glycine betaine
MNLHAPDI_02916 4.1e-217 amhX S amidohydrolase
MNLHAPDI_02917 5.6e-256 ycgA S Membrane
MNLHAPDI_02918 4.1e-81 ycgB
MNLHAPDI_02919 0.0 amyE 3.2.1.1 GH13 G alpha-amylase
MNLHAPDI_02920 1.2e-182 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
MNLHAPDI_02921 6.5e-293 lctP C L-lactate permease
MNLHAPDI_02922 6.2e-269 mdr EGP Major facilitator Superfamily
MNLHAPDI_02923 3.4e-77 emrR K helix_turn_helix multiple antibiotic resistance protein
MNLHAPDI_02924 6.8e-113 ycgF E Lysine exporter protein LysE YggA
MNLHAPDI_02925 1.2e-151 yqcI S YqcI/YcgG family
MNLHAPDI_02926 1.6e-249 ycgH E COG1113 Gamma-aminobutyrate permease and related permeases
MNLHAPDI_02927 2.4e-112 ycgI S Domain of unknown function (DUF1989)
MNLHAPDI_02928 1.5e-149 nadE 6.3.1.5 H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
MNLHAPDI_02929 2.1e-108 tmrB S AAA domain
MNLHAPDI_02930 3e-104 aroK 2.7.1.71, 4.2.3.4 F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MNLHAPDI_02931 3.4e-143 yafE Q ubiE/COQ5 methyltransferase family
MNLHAPDI_02932 1e-176 oxyR3 K LysR substrate binding domain
MNLHAPDI_02933 9.4e-183 cah 3.1.1.41 Q Acetyl xylan esterase (AXE1)
MNLHAPDI_02934 4.1e-144 ycgL S Predicted nucleotidyltransferase
MNLHAPDI_02935 1.9e-169 ycgM E Proline dehydrogenase
MNLHAPDI_02936 7.3e-294 rocA 1.2.1.88, 1.5.5.2 C Belongs to the aldehyde dehydrogenase family. RocA subfamily
MNLHAPDI_02937 2e-247 putP E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MNLHAPDI_02938 1.6e-227 ycgP QT COG2508 Regulator of polyketide synthase expression
MNLHAPDI_02939 9.1e-145 ycgQ S membrane
MNLHAPDI_02940 9.1e-140 ycgR S permeases
MNLHAPDI_02941 1.6e-157 I alpha/beta hydrolase fold
MNLHAPDI_02942 4e-192 ycgT 1.18.1.2, 1.19.1.1 C Ferredoxin--NADP reductase
MNLHAPDI_02943 8.7e-273 cobA 2.1.1.107, 4.2.1.75 H Belongs to the precorrin methyltransferase family
MNLHAPDI_02944 4.6e-57 nirD 1.7.1.15 P Nitrite reductase
MNLHAPDI_02945 0.0 nirB 1.7.1.15 C Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MNLHAPDI_02946 0.0 nasC C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MNLHAPDI_02947 0.0 nirB 1.7.1.15 C Assimilatory nitrate reductase (electron transfer subunit)
MNLHAPDI_02948 1.4e-220 nasA P COG2223 Nitrate nitrite transporter
MNLHAPDI_02949 1.4e-172 folE2 3.5.4.16 S Converts GTP to 7,8-dihydroneopterin triphosphate
MNLHAPDI_02950 5.5e-109 yciB M ErfK YbiS YcfS YnhG
MNLHAPDI_02951 4.6e-227 yciC S GTPases (G3E family)
MNLHAPDI_02952 5.4e-116 yecS P COG0765 ABC-type amino acid transport system, permease component
MNLHAPDI_02953 9.9e-131 yckB ET COG0834 ABC-type amino acid transport signal transduction systems, periplasmic component domain
MNLHAPDI_02956 6.2e-76 yckC S membrane
MNLHAPDI_02957 7.8e-52 yckD S Protein of unknown function (DUF2680)
MNLHAPDI_02958 8e-295 yckE 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
MNLHAPDI_02959 6.5e-69 nin S Competence protein J (ComJ)
MNLHAPDI_02960 3e-70 nucA M Deoxyribonuclease NucA/NucB
MNLHAPDI_02961 1.9e-186 tlpC 2.7.13.3 NT chemotaxis protein
MNLHAPDI_02962 1.8e-96 hxlB 4.1.2.43, 5.3.1.27 G SIS domain
MNLHAPDI_02963 3.6e-106 hxlA 4.1.2.43 G 3-hexulose-6-phosphate synthase
MNLHAPDI_02964 1.3e-63 hxlR K transcriptional
MNLHAPDI_02965 0.0 srfAA Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MNLHAPDI_02966 0.0 srfAB Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MNLHAPDI_02967 0.0 srfAC Q COG1020 Non-ribosomal peptide synthetase modules and related proteins
MNLHAPDI_02968 5.7e-140 srfAD Q thioesterase
MNLHAPDI_02969 4.2e-228 EGP Major Facilitator Superfamily
MNLHAPDI_02970 4.9e-91 S YcxB-like protein
MNLHAPDI_02971 7.4e-164 ycxC EG EamA-like transporter family
MNLHAPDI_02972 4.4e-255 ycxD K GntR family transcriptional regulator
MNLHAPDI_02973 5.5e-113 acpT 2.7.8.7 H Belongs to the P-Pant transferase superfamily
MNLHAPDI_02974 4.4e-115 yczE S membrane
MNLHAPDI_02975 2.8e-134 tcyC 3.6.3.21 E COG1126 ABC-type polar amino acid transport system, ATPase component
MNLHAPDI_02976 6.2e-123 tcyB P COG0765 ABC-type amino acid transport system, permease component
MNLHAPDI_02977 1.5e-141 tcyA ET Belongs to the bacterial solute-binding protein 3 family
MNLHAPDI_02978 4.9e-162 bsdA K LysR substrate binding domain
MNLHAPDI_02979 2e-109 ubiX 2.5.1.129 H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN
MNLHAPDI_02980 1.8e-283 yclC 4.1.1.61 H Decarboxylase involved in the decarboxylation and detoxification of phenolic derivatives under both aerobic and anaerobic conditions. It is able to catalyze the reversible decarboxylation of 4-hydroxybenzoate
MNLHAPDI_02981 4e-39 bsdD 4.1.1.61 S response to toxic substance
MNLHAPDI_02982 1.1e-83 yclD
MNLHAPDI_02983 6.2e-162 yclE 3.4.11.5 S Alpha beta hydrolase
MNLHAPDI_02984 1.5e-267 dtpT E amino acid peptide transporter
MNLHAPDI_02985 2.9e-310 yclG M Pectate lyase superfamily protein
MNLHAPDI_02987 1.8e-279 gerKA EG Spore germination protein
MNLHAPDI_02988 1.3e-232 gerKC S spore germination
MNLHAPDI_02989 1.7e-199 gerKB F Spore germination protein
MNLHAPDI_02990 1.9e-121 yclH P ABC transporter
MNLHAPDI_02991 3.6e-202 yclI V ABC transporter (permease) YclI
MNLHAPDI_02992 1.4e-127 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MNLHAPDI_02993 1.7e-260 yclK 2.7.13.3 T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain
MNLHAPDI_02994 5.2e-71 S aspartate phosphatase
MNLHAPDI_02998 1.7e-246 lysC 2.7.2.4 E Belongs to the aspartokinase family
MNLHAPDI_02999 3.5e-161 yclN P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MNLHAPDI_03000 1.3e-163 fatC P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MNLHAPDI_03001 1.1e-136 yclP 3.6.3.34 P ABC transporter, ATP-binding protein
MNLHAPDI_03002 1.4e-170 yclQ P COG4607 ABC-type enterochelin transport system, periplasmic component
MNLHAPDI_03003 4.1e-251 ycnB EGP Major facilitator Superfamily
MNLHAPDI_03004 5.5e-153 ycnC K Transcriptional regulator
MNLHAPDI_03005 2.2e-134 nfrA2 1.5.1.38, 1.5.1.39 C Oxidoreductase
MNLHAPDI_03006 1.6e-45 ycnE S Monooxygenase
MNLHAPDI_03007 2.2e-51 yczG K helix_turn_helix, Arsenical Resistance Operon Repressor
MNLHAPDI_03008 1.5e-272 gabR K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
MNLHAPDI_03009 3.1e-245 gabT 2.6.1.19, 2.6.1.22 E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MNLHAPDI_03010 3.8e-265 gabD 1.2.1.16, 1.2.1.20, 1.2.1.79 C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
MNLHAPDI_03011 6.1e-149 glcU U Glucose uptake
MNLHAPDI_03012 9.9e-146 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MNLHAPDI_03013 1.4e-99 ycnI S protein conserved in bacteria
MNLHAPDI_03014 1.4e-308 ycnJ P protein, homolog of Cu resistance protein CopC
MNLHAPDI_03015 4.3e-106 ycnK K COG1349 Transcriptional regulators of sugar metabolism
MNLHAPDI_03016 7.3e-56
MNLHAPDI_03017 5.6e-240 mtlA 2.7.1.197 G COG2213 Phosphotransferase system, mannitol-specific IIBC component
MNLHAPDI_03018 2e-71 mtlF 2.7.1.197 G COG4668 Mannitol fructose-specific phosphotransferase system, IIA domain
MNLHAPDI_03019 1.8e-209 mtlD 1.1.1.17 G COG0246 Mannitol-1-phosphate altronate dehydrogenases
MNLHAPDI_03020 1.6e-199 ycsA 1.1.1.83, 1.1.1.93, 4.1.1.73 CE Tartrate dehydrogenase
MNLHAPDI_03021 4.1e-10 sipT 3.4.21.89 U Belongs to the peptidase S26 family
MNLHAPDI_03022 1.3e-75 sipT 3.4.21.89 U Belongs to the peptidase S26 family
MNLHAPDI_03023 6.8e-110 M1-673 3.1.1.45 Q COG0412 Dienelactone hydrolase and related enzymes
MNLHAPDI_03024 3.5e-67 fabZ 3.5.1.108, 4.2.1.59 I FabA-like domain
MNLHAPDI_03026 8e-137 ycsE 3.1.3.104 S Sucrose-6F-phosphate phosphohydrolase
MNLHAPDI_03027 2.7e-140 ycsF S Belongs to the UPF0271 (lamB) family
MNLHAPDI_03028 2.1e-211 ycsG P COG1914 Mn2 and Fe2 transporters of the NRAMP family
MNLHAPDI_03029 9.6e-149 ycsI S Belongs to the D-glutamate cyclase family
MNLHAPDI_03030 1.4e-133 kipI 3.5.1.54 E Allophanate hydrolase subunit 1
MNLHAPDI_03031 5.1e-187 kipA 6.3.4.6 E Allophanate hydrolase subunit 2
MNLHAPDI_03032 2.7e-132 kipR K Transcriptional regulator
MNLHAPDI_03033 1.3e-119 ycsK E anatomical structure formation involved in morphogenesis
MNLHAPDI_03035 9.2e-49 yczJ S biosynthesis
MNLHAPDI_03036 0.0 pbpC 3.4.16.4 M Penicillin-binding Protein
MNLHAPDI_03037 8.3e-173 ydhF S Oxidoreductase
MNLHAPDI_03038 0.0 mtlR K transcriptional regulator, MtlR
MNLHAPDI_03039 3.2e-294 ydaB IQ acyl-CoA ligase
MNLHAPDI_03040 1.1e-99 ydaC Q Methyltransferase domain
MNLHAPDI_03041 1.4e-161 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MNLHAPDI_03042 1.2e-96 MA20_27600 5.3.1.15 S Cupin 2, conserved barrel domain protein
MNLHAPDI_03043 6.4e-99 rimL 1.1.1.25 J COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
MNLHAPDI_03044 6.8e-77 ydaG 1.4.3.5 S general stress protein
MNLHAPDI_03045 4.1e-139 amj U Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane
MNLHAPDI_03046 3.3e-46 ydzA EGP Major facilitator Superfamily
MNLHAPDI_03047 2.5e-74 lrpC K Transcriptional regulator
MNLHAPDI_03048 0.0 topB 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MNLHAPDI_03049 1.9e-208 ydaJ M Belongs to the glycosyl hydrolase 8 (cellulase D) family
MNLHAPDI_03050 2e-152 ydaK T Diguanylate cyclase, GGDEF domain
MNLHAPDI_03051 0.0 ydaL S Uncharacterized protein conserved in bacteria (DUF2334)
MNLHAPDI_03052 4.5e-233 ydaM M Glycosyl transferase family group 2
MNLHAPDI_03053 0.0 ydaN S Bacterial cellulose synthase subunit
MNLHAPDI_03054 0.0 ydaO E amino acid
MNLHAPDI_03055 1.1e-77 mutT 3.6.1.13, 3.6.1.55 L Belongs to the Nudix hydrolase family
MNLHAPDI_03056 0.0 poxB 1.2.3.3, 1.2.5.1 EH Belongs to the TPP enzyme family
MNLHAPDI_03057 2.1e-39
MNLHAPDI_03058 1e-224 mntH P H( )-stimulated, divalent metal cation uptake system
MNLHAPDI_03060 3.3e-77 ydaT S Uncharacterized protein conserved in bacteria (DUF2188)
MNLHAPDI_03061 2.4e-147 ydbA 3.6.3.4, 3.6.3.54 P EcsC protein family
MNLHAPDI_03063 8.9e-59 ydbB G Cupin domain
MNLHAPDI_03064 3.1e-62 ydbC S Domain of unknown function (DUF4937
MNLHAPDI_03065 3.5e-154 ydbD P Catalase
MNLHAPDI_03066 5.1e-198 dctB G COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component
MNLHAPDI_03067 4.8e-296 dctS 2.7.13.3 T Signal transduction histidine kinase regulating citrate malate metabolism
MNLHAPDI_03068 8.1e-120 dctR T COG4565 Response regulator of citrate malate metabolism
MNLHAPDI_03069 5.3e-226 dctA U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
MNLHAPDI_03070 9.7e-181 ydbI S AI-2E family transporter
MNLHAPDI_03071 3.6e-171 ydbJ V ABC transporter, ATP-binding protein
MNLHAPDI_03072 9.4e-125 ydbK S COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
MNLHAPDI_03073 2.7e-52 ydbL
MNLHAPDI_03074 1.4e-217 ydbM 1.3.8.1 I acyl-CoA dehydrogenase
MNLHAPDI_03075 1.1e-18 S Fur-regulated basic protein B
MNLHAPDI_03076 2.2e-07 S Fur-regulated basic protein A
MNLHAPDI_03077 9.6e-150 yeaB P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MNLHAPDI_03078 4.3e-55 ydbP 2.7.1.180, 5.3.4.1 CO Thioredoxin
MNLHAPDI_03079 3.9e-201 ddl 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
MNLHAPDI_03080 6.9e-254 murF 6.3.2.10 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
MNLHAPDI_03081 9e-249 cshA 3.6.4.13 JKL DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
MNLHAPDI_03082 2.1e-82 ydbS S Bacterial PH domain
MNLHAPDI_03083 1.1e-259 ydbT S Membrane
MNLHAPDI_03084 2.2e-105 ydcA 3.4.21.105 S membrane protein (homolog of Drosophila rhomboid)
MNLHAPDI_03085 2.1e-58 acpS 2.7.6.3, 2.7.8.7, 5.1.1.1 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
MNLHAPDI_03086 2.9e-183 ydcC M COG2834 Outer membrane lipoprotein-sorting protein
MNLHAPDI_03087 1.9e-222 alr 5.1.1.1, 5.1.1.5 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MNLHAPDI_03088 4.8e-42 ndoAI K transcriptional regulators containing the CopG Arc MetJ DNA-binding domain and a metal-binding domain
MNLHAPDI_03089 2.5e-56 ndoA L Toxic component of a toxin-antitoxin (TA) module
MNLHAPDI_03090 1.3e-143 rsbR T Positive regulator of sigma-B
MNLHAPDI_03091 5.2e-57 rsbS T antagonist
MNLHAPDI_03092 1.3e-69 rsbT 2.7.11.1 T COG2172 Anti-sigma regulatory factor (Ser Thr protein kinase)
MNLHAPDI_03093 7.1e-189 rsbU 3.1.3.3 KT phosphatase
MNLHAPDI_03094 7e-53 rsbV T Belongs to the anti-sigma-factor antagonist family
MNLHAPDI_03095 2.4e-86 rsbW 2.7.11.1 F Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B)
MNLHAPDI_03096 3.4e-138 sigB K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MNLHAPDI_03097 4.8e-108 rsbX 3.1.3.16, 3.1.3.3 KT Sigma factor PP2C-like phosphatases
MNLHAPDI_03101 1.5e-82 ydcG S EVE domain
MNLHAPDI_03102 1.6e-76 ydcH K helix_turn_helix multiple antibiotic resistance protein
MNLHAPDI_03103 0.0 yhgF K COG2183 Transcriptional accessory protein
MNLHAPDI_03104 1.6e-84 ydcK S Belongs to the SprT family
MNLHAPDI_03112 1.7e-75 rimJ2 J Acetyltransferase (GNAT) domain
MNLHAPDI_03113 8.5e-45
MNLHAPDI_03114 5.7e-138 L A nuclease of the HNH/ENDO VII superfamily with conserved LHH
MNLHAPDI_03115 1.7e-32 K Helix-turn-helix XRE-family like proteins
MNLHAPDI_03116 9.6e-40
MNLHAPDI_03120 1.4e-112 ydeA 1.11.1.6, 3.5.1.124 S DJ-1/PfpI family
MNLHAPDI_03121 8.7e-30 cspL K Cold shock
MNLHAPDI_03122 1.5e-77 carD K Transcription factor
MNLHAPDI_03123 4.4e-142 ydzE EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
MNLHAPDI_03124 1.4e-164 rhaS5 K AraC-like ligand binding domain
MNLHAPDI_03125 3.2e-170 yicL EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
MNLHAPDI_03126 1.4e-164 ydeE K AraC family transcriptional regulator
MNLHAPDI_03127 1.1e-259 K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
MNLHAPDI_03128 1.8e-216 ydeG EGP Major facilitator superfamily
MNLHAPDI_03129 2.7e-45 ydeH
MNLHAPDI_03130 2.4e-104 ydeI S Bacteriocin-protection, YdeI or OmpD-Associated
MNLHAPDI_03131 1.3e-109
MNLHAPDI_03132 1.1e-31 S SNARE associated Golgi protein
MNLHAPDI_03133 1.8e-14 ptsH G PTS HPr component phosphorylation site
MNLHAPDI_03134 3.4e-84 K Transcriptional regulator C-terminal region
MNLHAPDI_03135 2e-152 ydeK EG -transporter
MNLHAPDI_03136 8.7e-270 ydeL K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
MNLHAPDI_03137 1.3e-72 maoC I N-terminal half of MaoC dehydratase
MNLHAPDI_03138 1.8e-104 ydeN S Serine hydrolase
MNLHAPDI_03139 5.7e-55 K HxlR-like helix-turn-helix
MNLHAPDI_03140 6e-152 yqfU S Uncharacterized protein conserved in bacteria (DUF2179)
MNLHAPDI_03141 1.8e-68 ydeP K Transcriptional regulator
MNLHAPDI_03142 1.7e-110 ydeQ S NADPH-quinone reductase (modulator of drug activity B)
MNLHAPDI_03143 1.5e-185 ydeR EGP Major facilitator Superfamily
MNLHAPDI_03144 2.5e-104 ydeS K Transcriptional regulator
MNLHAPDI_03145 1.8e-56 arsR K transcriptional
MNLHAPDI_03146 2.6e-231 arsB P Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MNLHAPDI_03147 2.1e-148 ydfB J GNAT acetyltransferase
MNLHAPDI_03148 8.8e-162 ydfC EG EamA-like transporter family
MNLHAPDI_03149 1.9e-275 ydfD K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
MNLHAPDI_03150 5.9e-117 ydfE S Flavin reductase like domain
MNLHAPDI_03151 2.7e-123 ydfF K helix_turn_helix, Arsenical Resistance Operon Repressor
MNLHAPDI_03152 1.5e-79 ydfG S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MNLHAPDI_03154 5.3e-180 ydfH 2.7.13.3 T Histidine kinase
MNLHAPDI_03155 1.4e-110 ydfI K Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MNLHAPDI_03156 0.0 ydfJ S drug exporters of the RND superfamily
MNLHAPDI_03158 1.9e-177 S Alpha/beta hydrolase family
MNLHAPDI_03159 5.9e-118 S Protein of unknown function (DUF554)
MNLHAPDI_03160 3.2e-147 K Bacterial transcription activator, effector binding domain
MNLHAPDI_03161 1.6e-155 fieF P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MNLHAPDI_03162 9.6e-112 ydfN C nitroreductase
MNLHAPDI_03163 3.6e-187 ydfO E COG0346 Lactoylglutathione lyase and related lyases
MNLHAPDI_03164 8.8e-63 mhqP S DoxX
MNLHAPDI_03165 1.3e-57 traF CO Thioredoxin
MNLHAPDI_03166 7.1e-15 ydgA S Spore germination protein gerPA/gerPF
MNLHAPDI_03167 6.3e-29
MNLHAPDI_03169 4.4e-118 ydfR S Protein of unknown function (DUF421)
MNLHAPDI_03170 5.2e-122 ydfS S Protein of unknown function (DUF421)
MNLHAPDI_03171 2.2e-75 cotP O Belongs to the small heat shock protein (HSP20) family
MNLHAPDI_03172 1.4e-37 ydgA S Spore germination protein gerPA/gerPF
MNLHAPDI_03173 1.3e-41 ydgB S Spore germination protein gerPA/gerPF
MNLHAPDI_03174 1.5e-101 K Bacterial regulatory proteins, tetR family
MNLHAPDI_03175 7.3e-53 S DoxX-like family
MNLHAPDI_03176 2.4e-86 yycN 2.3.1.128 K Acetyltransferase
MNLHAPDI_03177 7.5e-305 expZ S ABC transporter
MNLHAPDI_03178 5.2e-251 cycA E COG1113 Gamma-aminobutyrate permease and related permeases
MNLHAPDI_03179 2.3e-90 dinB S DinB family
MNLHAPDI_03180 4.7e-80 K helix_turn_helix multiple antibiotic resistance protein
MNLHAPDI_03181 0.0 ydgH S drug exporters of the RND superfamily
MNLHAPDI_03182 1.2e-112 drgA C nitroreductase
MNLHAPDI_03183 7.1e-69 ydgJ K Winged helix DNA-binding domain
MNLHAPDI_03184 2.2e-208 tcaB EGP Major facilitator Superfamily
MNLHAPDI_03185 1.2e-121 ydhB S membrane transporter protein
MNLHAPDI_03186 6.5e-122 ydhC K FCD
MNLHAPDI_03187 3.3e-244 ydhD M Glycosyl hydrolase
MNLHAPDI_03188 7e-228 ydhE CG COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase
MNLHAPDI_03189 1.9e-127
MNLHAPDI_03190 1.4e-259 phoB 3.1.3.1 P Belongs to the alkaline phosphatase family
MNLHAPDI_03191 4.6e-69 frataxin S Domain of unknown function (DU1801)
MNLHAPDI_03193 4.1e-86 K Acetyltransferase (GNAT) domain
MNLHAPDI_03194 1.8e-184 ydhJ S Metal dependent phosphohydrolases with conserved 'HD' motif.
MNLHAPDI_03195 1.7e-99 ydhK M Protein of unknown function (DUF1541)
MNLHAPDI_03196 4.6e-200 pbuE EGP Major facilitator Superfamily
MNLHAPDI_03197 1.1e-47 ydhM 2.7.1.196, 2.7.1.205 G phosphotransferase system
MNLHAPDI_03198 3.5e-52 ydhN3 2.7.1.196, 2.7.1.205 G phosphotransferase system
MNLHAPDI_03199 2e-239 celB G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
MNLHAPDI_03200 2.4e-288 ydhP 3.2.1.21, 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
MNLHAPDI_03201 1.1e-132 ydhQ K UTRA
MNLHAPDI_03202 1.5e-166 gmuE 2.7.1.2, 2.7.1.4 GK COG1940 Transcriptional regulator sugar kinase
MNLHAPDI_03203 4e-186 manA 5.3.1.8 G mannose-6-phosphate isomerase
MNLHAPDI_03204 3.5e-210 gmuG 3.2.1.78 GH26 G Belongs to the glycosyl hydrolase 26 family
MNLHAPDI_03205 1.8e-156 ydhU P Catalase
MNLHAPDI_03208 3.4e-39 S COG NOG14552 non supervised orthologous group
MNLHAPDI_03209 7.8e-08
MNLHAPDI_03211 1.3e-179 thiL 2.7.4.16 H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MNLHAPDI_03212 5.9e-85 ydiB 2.7.1.221, 5.1.1.1 S ATPase or kinase
MNLHAPDI_03213 9e-127 yeaZ 2.3.1.234 O COG1214 Inactive homolog of metal-dependent proteases
MNLHAPDI_03214 1.3e-84 rimI 2.3.1.128 K This enzyme acetylates the N-terminal alanine of ribosomal protein S18
MNLHAPDI_03215 2e-186 tsaD 2.3.1.234 O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MNLHAPDI_03216 0.0 ydiF S ABC transporter
MNLHAPDI_03217 2.1e-88 moaC 4.6.1.17 H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)
MNLHAPDI_03218 8.8e-116 rex K Modulates transcription in response to changes in cellular NADH NAD( ) redox state
MNLHAPDI_03219 7.5e-22 tatA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
MNLHAPDI_03220 4.1e-125 tatC U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MNLHAPDI_03221 2.9e-27 ydiK S Domain of unknown function (DUF4305)
MNLHAPDI_03222 7.9e-129 ydiL S CAAX protease self-immunity
MNLHAPDI_03223 1.3e-42 groS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MNLHAPDI_03224 1.2e-281 groL O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
MNLHAPDI_03226 6.4e-66 KL Phage plasmid primase P4 family
MNLHAPDI_03227 1.1e-250 2.1.1.37 L DNA (cytosine-5-)-methyltransferase activity
MNLHAPDI_03228 1.6e-232 ydiP 2.1.1.37 H Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family
MNLHAPDI_03230 1.2e-199 V AAA domain (dynein-related subfamily)
MNLHAPDI_03231 4.9e-257 J LlaJI restriction endonuclease
MNLHAPDI_03232 1.1e-08 ydjC S Abhydrolase domain containing 18
MNLHAPDI_03233 0.0 K NB-ARC domain
MNLHAPDI_03234 3.8e-201 gutB 1.1.1.14 E Dehydrogenase
MNLHAPDI_03235 7.1e-256 gutA G MFS/sugar transport protein
MNLHAPDI_03236 1.5e-175 ydjE 2.7.1.4 G pfkB family carbohydrate kinase
MNLHAPDI_03237 5.1e-114 pspA KT Phage shock protein A
MNLHAPDI_03238 3.4e-178 ydjG 3.6.4.12 L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MNLHAPDI_03239 1.6e-137 ydjH S COG1512 Beta-propeller domains of methanol dehydrogenase type
MNLHAPDI_03240 1.4e-149 ydjI S virion core protein (lumpy skin disease virus)
MNLHAPDI_03241 4.7e-196 S Ion transport 2 domain protein
MNLHAPDI_03242 2.7e-258 iolT EGP Major facilitator Superfamily
MNLHAPDI_03243 5.2e-195 bdhA 1.1.1.303, 1.1.1.4 E Dehydrogenase
MNLHAPDI_03244 4.5e-64 ydjM M Lytic transglycolase
MNLHAPDI_03245 2.3e-150 ydjN U Involved in the tonB-independent uptake of proteins
MNLHAPDI_03247 1.4e-34 ydjO S Cold-inducible protein YdjO
MNLHAPDI_03248 8.4e-156 ydjP I Alpha/beta hydrolase family
MNLHAPDI_03249 3.3e-175 yeaA S Protein of unknown function (DUF4003)
MNLHAPDI_03250 0.0 cotA 1.10.3.4, 1.16.3.3 Q multicopper oxidases
MNLHAPDI_03251 2.6e-253 gabP E COG1113 Gamma-aminobutyrate permease and related permeases
MNLHAPDI_03252 7.6e-155 yeaB P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MNLHAPDI_03253 1.5e-175 yeaC S COG0714 MoxR-like ATPases
MNLHAPDI_03254 8.9e-223 yeaD S conserved protein (some members contain a von Willebrand factor type A (vWA) domain)
MNLHAPDI_03255 0.0 yebA E COG1305 Transglutaminase-like enzymes
MNLHAPDI_03256 8.3e-306 guaA 2.3.1.128, 6.3.5.2 F Catalyzes the synthesis of GMP from XMP
MNLHAPDI_03257 2e-89 K Belongs to the sigma-70 factor family. ECF subfamily
MNLHAPDI_03258 9.8e-256 S Domain of unknown function (DUF4179)
MNLHAPDI_03259 7.8e-212 pbuG S permease
MNLHAPDI_03260 1.9e-115 yebC M Membrane
MNLHAPDI_03262 4e-93 yebE S UPF0316 protein
MNLHAPDI_03263 8e-28 yebG S NETI protein
MNLHAPDI_03264 7.4e-83 purE 5.4.99.18 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MNLHAPDI_03265 1.6e-213 purK 6.3.4.18 F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MNLHAPDI_03266 9.6e-247 purB 4.3.2.2 F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MNLHAPDI_03267 3.7e-131 purC 4.1.1.21, 4.3.2.2, 6.3.2.6 F Belongs to the SAICAR synthetase family
MNLHAPDI_03268 2.9e-38 purS 6.3.2.6, 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MNLHAPDI_03269 5.1e-130 purQ 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MNLHAPDI_03270 0.0 purL 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MNLHAPDI_03271 1.2e-271 purF 2.4.2.14 F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MNLHAPDI_03272 3.8e-177 purM 6.3.3.1, 6.3.4.13 F Phosphoribosylformylglycinamidine cyclo-ligase
MNLHAPDI_03273 3.7e-105 purN 2.1.2.2 F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MNLHAPDI_03274 2.7e-288 purH 2.1.2.3, 3.5.4.10 F Bifunctional purine biosynthesis protein PurH
MNLHAPDI_03275 1.7e-235 purD 6.3.4.13 F Belongs to the GARS family
MNLHAPDI_03276 3.5e-73 K helix_turn_helix ASNC type
MNLHAPDI_03277 6.4e-227 yjeH E Amino acid permease
MNLHAPDI_03278 2.7e-27 S Protein of unknown function (DUF2892)
MNLHAPDI_03279 0.0 yerA 3.5.4.2 F adenine deaminase
MNLHAPDI_03280 8.3e-190 yerB S Protein of unknown function (DUF3048) C-terminal domain
MNLHAPDI_03281 4.8e-51 yerC S protein conserved in bacteria
MNLHAPDI_03282 8.8e-303 yerD 1.4.7.1 E Belongs to the glutamate synthase family
MNLHAPDI_03283 4.9e-125 pcrB I 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
MNLHAPDI_03284 0.0 pcrA 3.6.4.12 L ATP-dependent DNA helicase
MNLHAPDI_03285 0.0 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MNLHAPDI_03286 4.1e-220 camS S COG4851 Protein involved in sex pheromone biosynthesis
MNLHAPDI_03287 2.7e-196 yerI S homoserine kinase type II (protein kinase fold)
MNLHAPDI_03288 6.1e-123 sapB S MgtC SapB transporter
MNLHAPDI_03289 2e-264 putP E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MNLHAPDI_03290 2.1e-45 gatC 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MNLHAPDI_03291 3.6e-274 gatA 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
MNLHAPDI_03292 3.1e-270 gatB 6.1.1.12, 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MNLHAPDI_03293 1.3e-148 yerO K Transcriptional regulator
MNLHAPDI_03294 0.0 swrC V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MNLHAPDI_03295 3e-170 yegS 2.7.1.107 I COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
MNLHAPDI_03296 1.2e-255 rumA 2.1.1.190 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MNLHAPDI_03297 3.2e-98 L Recombinase
MNLHAPDI_03298 3.2e-53 L Resolvase, N terminal domain
MNLHAPDI_03299 0.0 yeeA V Type II restriction enzyme, methylase subunits
MNLHAPDI_03300 0.0 yeeB L DEAD-like helicases superfamily
MNLHAPDI_03301 1.2e-211 pstS P T5orf172
MNLHAPDI_03303 6.2e-31 S Colicin immunity protein / pyocin immunity protein
MNLHAPDI_03304 5.5e-83 S Protein of unknown function, DUF600
MNLHAPDI_03305 0.0 L nucleic acid phosphodiester bond hydrolysis
MNLHAPDI_03306 1.8e-192 3.4.24.40 CO amine dehydrogenase activity
MNLHAPDI_03307 5.5e-214 S Tetratricopeptide repeat
MNLHAPDI_03309 9.4e-127 yeeN K transcriptional regulatory protein
MNLHAPDI_03311 1.2e-103 dhaR3 K Transcriptional regulator
MNLHAPDI_03312 9.7e-82 yesE S SnoaL-like domain
MNLHAPDI_03313 6.2e-154 yesF GM NAD(P)H-binding
MNLHAPDI_03314 5.3e-45 cotJA S Spore coat associated protein JA (CotJA)
MNLHAPDI_03315 1.5e-45 cotJB S CotJB protein
MNLHAPDI_03316 5.2e-104 cotJC P Spore Coat
MNLHAPDI_03317 4.6e-102 yesJ K Acetyltransferase (GNAT) family
MNLHAPDI_03319 2.9e-100 yesL S Protein of unknown function, DUF624
MNLHAPDI_03320 0.0 yesM 2.7.13.3 T Histidine kinase
MNLHAPDI_03321 1.4e-201 yesN K helix_turn_helix, arabinose operon control protein
MNLHAPDI_03322 4e-245 yesO G Bacterial extracellular solute-binding protein
MNLHAPDI_03323 2.8e-171 yesP G Binding-protein-dependent transport system inner membrane component
MNLHAPDI_03324 7.7e-163 yesQ P Binding-protein-dependent transport system inner membrane component
MNLHAPDI_03325 2.9e-198 3.2.1.172 GH105 S Glycosyl Hydrolase Family 88
MNLHAPDI_03326 0.0 yesS K Transcriptional regulator
MNLHAPDI_03327 9.7e-129 E GDSL-like Lipase/Acylhydrolase
MNLHAPDI_03328 7.1e-129 yesU S Domain of unknown function (DUF1961)
MNLHAPDI_03329 3e-113 yesV S Protein of unknown function, DUF624
MNLHAPDI_03330 0.0 yesX 4.2.2.23, 4.2.2.24 PL11 E cell wall organization
MNLHAPDI_03331 0.0 yesX 4.2.2.23, 4.2.2.24 PL11 E cell wall organization
MNLHAPDI_03332 3e-124 yesY E GDSL-like Lipase/Acylhydrolase
MNLHAPDI_03333 0.0 yesZ 3.2.1.23 G beta-galactosidase activity
MNLHAPDI_03334 0.0 yetA
MNLHAPDI_03335 9.6e-291 lplA G Bacterial extracellular solute-binding protein
MNLHAPDI_03336 1.3e-176 lplB G COG4209 ABC-type polysaccharide transport system, permease component
MNLHAPDI_03337 1.7e-162 lplC G Binding-protein-dependent transport system inner membrane component
MNLHAPDI_03338 2.4e-253 lplD 3.2.1.122, 3.2.1.22, 3.2.1.86 GH4,GT4 G Family 4 glycosyl hydrolase
MNLHAPDI_03339 8.8e-122 yetF S membrane
MNLHAPDI_03340 4.4e-55 isdI 1.14.99.48, 1.14.99.57 S Antibiotic biosynthesis monooxygenase
MNLHAPDI_03341 2e-64 yetH E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
MNLHAPDI_03342 2.2e-34
MNLHAPDI_03343 5.4e-145 T COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
MNLHAPDI_03344 8.9e-20 yezD S Uncharacterized small protein (DUF2292)
MNLHAPDI_03345 5.3e-105 yetJ S Belongs to the BI1 family
MNLHAPDI_03346 5.4e-159 yetK EG EamA-like transporter family
MNLHAPDI_03347 6.4e-90 yetL K helix_turn_helix multiple antibiotic resistance protein
MNLHAPDI_03348 7.8e-213 yetM CH FAD binding domain
MNLHAPDI_03349 3.6e-199 yetN S Protein of unknown function (DUF3900)
MNLHAPDI_03350 0.0 cypD 1.14.14.1, 1.6.2.4 C Belongs to the cytochrome P450 family
MNLHAPDI_03351 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
MNLHAPDI_03352 2.1e-148 rfbF 2.7.7.33 JM Nucleotidyl transferase
MNLHAPDI_03353 1.9e-172 yfnG 4.2.1.45 M dehydratase
MNLHAPDI_03354 3.8e-181 yfnF M Nucleotide-diphospho-sugar transferase
MNLHAPDI_03355 1.4e-225 yfnE 2.4.1.338 GT2 S Glycosyltransferase like family 2
MNLHAPDI_03356 1e-189 yfnD M Nucleotide-diphospho-sugar transferase
MNLHAPDI_03357 4.6e-206 fsr P COG0477 Permeases of the major facilitator superfamily
MNLHAPDI_03358 8.1e-131 yjjG 3.1.3.102, 3.1.3.104, 3.1.3.5, 3.8.1.2 S Haloacid dehalogenase-like hydrolase
MNLHAPDI_03359 8.4e-241 yfnA E amino acid
MNLHAPDI_03360 3.7e-279 yfmT 1.2.1.3, 1.2.1.67 C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
MNLHAPDI_03361 1.1e-113 yfmS NT chemotaxis protein
MNLHAPDI_03362 0.0 yfmR S COG0488 ATPase components of ABC transporters with duplicated ATPase domains
MNLHAPDI_03363 1.7e-73 yfmQ S Uncharacterised protein from bacillus cereus group
MNLHAPDI_03364 1.4e-69 yfmP K transcriptional
MNLHAPDI_03365 1.5e-209 yfmO EGP Major facilitator Superfamily
MNLHAPDI_03366 1.9e-297 yfmM S COG0488 ATPase components of ABC transporters with duplicated ATPase domains
MNLHAPDI_03367 6.3e-202 yfmL 3.6.4.13 L COG0513 Superfamily II DNA and RNA helicases
MNLHAPDI_03368 7.5e-82 yfmK 2.3.1.128 K acetyltransferase
MNLHAPDI_03369 8.5e-190 yfmJ S N-terminal domain of oxidoreductase
MNLHAPDI_03370 2.2e-213 G Major Facilitator Superfamily
MNLHAPDI_03371 3.3e-296 1.14.99.50 S Sulfatase-modifying factor enzyme 1
MNLHAPDI_03372 1.1e-149 yfmF 3.6.3.34 P ATPases associated with a variety of cellular activities
MNLHAPDI_03373 2e-167 fecD P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MNLHAPDI_03374 4.7e-169 viuD P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MNLHAPDI_03375 1.7e-168 fecB P COG4594 ABC-type Fe3 -citrate transport system, periplasmic component
MNLHAPDI_03376 2.9e-24 S Protein of unknown function (DUF3212)
MNLHAPDI_03377 7.6e-58 yflT S Heat induced stress protein YflT
MNLHAPDI_03378 3.8e-240 pel 4.2.2.10, 4.2.2.2 G Pectate lyase
MNLHAPDI_03379 3.2e-235 yflS P Sodium:sulfate symporter transmembrane region
MNLHAPDI_03380 5.3e-287 citS 2.7.13.3 T Signal transduction histidine kinase regulating citrate malate metabolism
MNLHAPDI_03381 8.9e-119 citT T response regulator
MNLHAPDI_03382 2.8e-179 yflP S Tripartite tricarboxylate transporter family receptor
MNLHAPDI_03383 1.9e-226 citM C Citrate transporter
MNLHAPDI_03384 5.5e-152 yflN S COG0491 Zn-dependent hydrolases, including glyoxylases
MNLHAPDI_03385 1.3e-217 nos 1.14.14.47 C Belongs to the NOS family. Bacterial NOS oxygenase subfamily
MNLHAPDI_03386 2.9e-44 acyP 3.6.1.7 C Belongs to the acylphosphatase family
MNLHAPDI_03387 9e-124 yflK S protein conserved in bacteria
MNLHAPDI_03388 4e-18 yflJ S Protein of unknown function (DUF2639)
MNLHAPDI_03389 4.1e-19 yflI
MNLHAPDI_03390 2.4e-50 yflH S Protein of unknown function (DUF3243)
MNLHAPDI_03391 1.9e-138 map 3.4.11.18 E Methionine aminopeptidase
MNLHAPDI_03392 1.5e-250 nagE 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G COG1263 Phosphotransferase system IIC components, glucose maltose N-acetylglucosamine-specific
MNLHAPDI_03393 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
MNLHAPDI_03394 5.1e-66 yhdN S Domain of unknown function (DUF1992)
MNLHAPDI_03395 2.2e-252 agcS_1 E Sodium alanine symporter
MNLHAPDI_03396 1.3e-193 E Spore germination protein
MNLHAPDI_03398 5.1e-207 yfkR S spore germination
MNLHAPDI_03399 4.1e-281 yfkQ EG Spore germination protein
MNLHAPDI_03400 2.5e-256 treP 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
MNLHAPDI_03401 0.0 treC 3.2.1.93 GH13 G COG0366 Glycosidases
MNLHAPDI_03402 1.8e-133 treR K transcriptional
MNLHAPDI_03403 1.1e-124 yfkO C nitroreductase
MNLHAPDI_03404 0.0 cpdB 3.1.3.5, 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
MNLHAPDI_03405 9.6e-89 yfkM 1.11.1.6, 3.5.1.124 S protease
MNLHAPDI_03406 7.5e-206 ydiM EGP Major facilitator Superfamily
MNLHAPDI_03407 2.3e-28 yfkK S Belongs to the UPF0435 family
MNLHAPDI_03408 2.2e-84 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MNLHAPDI_03409 2.4e-50 yfkI S gas vesicle protein
MNLHAPDI_03410 1.3e-143 yihY S Belongs to the UPF0761 family
MNLHAPDI_03411 5e-08
MNLHAPDI_03412 3.4e-219 ycaD EGP COG0477 Permeases of the major facilitator superfamily
MNLHAPDI_03413 1.8e-182 cax P COG0387 Ca2 H antiporter
MNLHAPDI_03414 1.2e-146 yfkD S YfkD-like protein
MNLHAPDI_03415 1e-148 yfkC M Mechanosensitive ion channel
MNLHAPDI_03416 5.4e-222 yfkA S YfkB-like domain
MNLHAPDI_03417 1.1e-26 yfjT
MNLHAPDI_03418 4.9e-153 pdaA G deacetylase
MNLHAPDI_03419 1.8e-148 yfjR 1.1.1.31 I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
MNLHAPDI_03420 1.7e-184 corA P Mediates influx of magnesium ions
MNLHAPDI_03421 1e-167 yfjP 3.2.2.21 L COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
MNLHAPDI_03422 1.1e-267 rumA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MNLHAPDI_03423 1.6e-39 S YfzA-like protein
MNLHAPDI_03424 1.1e-186 yfjN J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MNLHAPDI_03425 1.1e-83 yfjM S Psort location Cytoplasmic, score
MNLHAPDI_03426 3e-29 yfjL
MNLHAPDI_03427 1.2e-191 acoA C COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
MNLHAPDI_03428 1e-190 acoB C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
MNLHAPDI_03429 2.9e-197 acoC 2.3.1.12, 2.3.1.61 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
MNLHAPDI_03430 1.2e-255 acoL 1.8.1.4 C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
MNLHAPDI_03431 0.0 acoR KQ COG3284 Transcriptional activator of acetoin glycerol metabolism
MNLHAPDI_03432 9.8e-25 sspH S Belongs to the SspH family
MNLHAPDI_03433 4e-56 yfjF S UPF0060 membrane protein
MNLHAPDI_03434 1.1e-79 S Family of unknown function (DUF5381)
MNLHAPDI_03435 1.8e-101 yfjD S Family of unknown function (DUF5381)
MNLHAPDI_03436 4.5e-143 yfjC
MNLHAPDI_03437 9.2e-191 yfjB
MNLHAPDI_03438 7.4e-44 yfjA S Belongs to the WXG100 family
MNLHAPDI_03439 9.9e-263 aglB 3.2.1.122, 3.2.1.22, 3.2.1.86 GH4,GT4 G COG1486 Alpha-galactosidases 6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases
MNLHAPDI_03440 3.2e-141 glvR K Helix-turn-helix domain, rpiR family
MNLHAPDI_03441 4.7e-296 glvC 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
MNLHAPDI_03442 2.1e-310 yfiB3 V ABC transporter
MNLHAPDI_03443 0.0 yfiC V COG1132 ABC-type multidrug transport system, ATPase and permease components
MNLHAPDI_03444 9.8e-65 mhqP S DoxX
MNLHAPDI_03445 5.7e-163 yfiE 1.13.11.2 S glyoxalase
MNLHAPDI_03446 1.5e-177 K AraC-like ligand binding domain
MNLHAPDI_03447 1.8e-262 iolT EGP Major facilitator Superfamily
MNLHAPDI_03448 8.4e-184 G Xylose isomerase
MNLHAPDI_03449 1.1e-233 S Oxidoreductase
MNLHAPDI_03451 1.1e-214 yxjM T Histidine kinase
MNLHAPDI_03452 3.2e-113 KT LuxR family transcriptional regulator
MNLHAPDI_03453 6.2e-171 V ABC transporter, ATP-binding protein
MNLHAPDI_03454 9.8e-214 V ABC-2 family transporter protein
MNLHAPDI_03455 4.6e-208 V COG0842 ABC-type multidrug transport system, permease component
MNLHAPDI_03456 8.3e-99 padR K transcriptional
MNLHAPDI_03457 4.4e-80 estA 3.1.1.3 S acetyltransferases and hydrolases with the alpha beta hydrolase fold
MNLHAPDI_03458 9e-198 yfiQ G COG3936 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
MNLHAPDI_03459 2e-109 yfiR K Transcriptional regulator
MNLHAPDI_03460 5.1e-221 yfiS EGP Major facilitator Superfamily
MNLHAPDI_03461 3.3e-100 yfiT S Belongs to the metal hydrolase YfiT family
MNLHAPDI_03462 8.7e-287 yfiU EGP Major facilitator Superfamily
MNLHAPDI_03463 3.1e-81 yfiV K transcriptional
MNLHAPDI_03464 0.0 mprF 2.3.2.3 S Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MNLHAPDI_03465 6.2e-182 yfiY P ABC transporter substrate-binding protein
MNLHAPDI_03466 3.1e-176 yfiZ P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MNLHAPDI_03467 6.8e-171 yfhA P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MNLHAPDI_03468 1.3e-165 yfhB 5.3.3.17 S PhzF family
MNLHAPDI_03469 1.5e-106 yfhC C nitroreductase
MNLHAPDI_03470 2.1e-25 yfhD S YfhD-like protein
MNLHAPDI_03472 1.4e-172 yfhF S nucleoside-diphosphate sugar epimerase
MNLHAPDI_03473 2.5e-141 recX 2.4.1.337 GT4 S Modulates RecA activity
MNLHAPDI_03474 9.7e-52 yfhH S Protein of unknown function (DUF1811)
MNLHAPDI_03476 1.1e-209 yfhI EGP Major facilitator Superfamily
MNLHAPDI_03477 6.2e-20 sspK S reproduction
MNLHAPDI_03478 2.9e-44 yfhJ S WVELL protein
MNLHAPDI_03479 2.4e-87 batE T Bacterial SH3 domain homologues
MNLHAPDI_03480 3.5e-51 yfhL S SdpI/YhfL protein family
MNLHAPDI_03481 6.7e-172 yfhM S Alpha beta hydrolase
MNLHAPDI_03482 2.7e-185 csbB GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
MNLHAPDI_03483 0.0 yfhO S Bacterial membrane protein YfhO
MNLHAPDI_03484 5.5e-186 yfhP S membrane-bound metal-dependent
MNLHAPDI_03485 1.7e-211 mutY L A G-specific
MNLHAPDI_03486 6.9e-36 yfhS
MNLHAPDI_03487 2.9e-134 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MNLHAPDI_03488 2.4e-08 sspE S Small, acid-soluble spore protein, gamma-type
MNLHAPDI_03489 1.5e-37 ygaB S YgaB-like protein
MNLHAPDI_03490 1.3e-104 ygaC J Belongs to the UPF0374 family
MNLHAPDI_03491 1.8e-301 ygaD V ABC transporter
MNLHAPDI_03492 8.7e-180 ygaE S Membrane
MNLHAPDI_03493 1.2e-246 gsaB 5.4.3.8 H Glutamate-1-semialdehyde aminotransferase
MNLHAPDI_03494 2.8e-87 bcp 1.11.1.15 O Peroxiredoxin
MNLHAPDI_03495 4e-80 perR P Belongs to the Fur family
MNLHAPDI_03496 1.5e-56 ygzB S UPF0295 protein
MNLHAPDI_03497 6.7e-167 ygxA S Nucleotidyltransferase-like
MNLHAPDI_03498 3.4e-39 S COG NOG14552 non supervised orthologous group
MNLHAPDI_03503 7.8e-08
MNLHAPDI_03511 2e-08
MNLHAPDI_03515 2.7e-143 spo0M S COG4326 Sporulation control protein
MNLHAPDI_03516 3e-27
MNLHAPDI_03517 5.9e-134 pepE 3.4.11.2, 3.4.13.21 E Belongs to the peptidase S51 family
MNLHAPDI_03518 0.0 thiC 4.1.99.17 H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MNLHAPDI_03519 1.9e-266 ygaK C Berberine and berberine like
MNLHAPDI_03521 3.2e-291 katA 1.11.1.6 P serves to protect cells from the toxic effects of hydrogen peroxide
MNLHAPDI_03522 1.1e-145 ssuB P COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component
MNLHAPDI_03523 1.7e-171 ssuA M Sulfonate ABC transporter
MNLHAPDI_03524 1.5e-147 ssuC P COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component
MNLHAPDI_03525 3.1e-217 ssuD 1.14.14.5 C Catalyzes the desulfonation of aliphatic sulfonates
MNLHAPDI_03527 6e-42 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MNLHAPDI_03528 4.1e-78 ygaO
MNLHAPDI_03529 4.4e-29 K Transcriptional regulator
MNLHAPDI_03531 7.9e-114 yhzB S B3/4 domain
MNLHAPDI_03532 2.1e-224 queG 1.17.99.6 C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MNLHAPDI_03533 4.4e-177 yhbB S Putative amidase domain
MNLHAPDI_03534 8.2e-87 trmL 2.1.1.207 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
MNLHAPDI_03535 1.2e-109 yhbD K Protein of unknown function (DUF4004)
MNLHAPDI_03536 1.6e-65 yhbE M COG1664 Integral membrane protein CcmA involved in cell shape determination
MNLHAPDI_03537 8.2e-75 yhbF M COG1664 Integral membrane protein CcmA involved in cell shape determination
MNLHAPDI_03538 0.0 prkA T Ser protein kinase
MNLHAPDI_03539 2.5e-225 yhbH S Belongs to the UPF0229 family
MNLHAPDI_03540 2.2e-76 yhbI K DNA-binding transcription factor activity
MNLHAPDI_03541 4e-97 yhbJ V COG1566 Multidrug resistance efflux pump
MNLHAPDI_03542 3.1e-271 yhcA EGP Major facilitator Superfamily
MNLHAPDI_03543 1.4e-98 yhcB 1.6.5.2 S Belongs to the WrbA family
MNLHAPDI_03544 2.8e-37 yhcC
MNLHAPDI_03545 2e-55
MNLHAPDI_03546 6.6e-60 yhcF K Transcriptional regulator
MNLHAPDI_03547 1.6e-123 yhcG V ABC transporter, ATP-binding protein
MNLHAPDI_03548 7.7e-166 yhcH V ABC transporter, ATP-binding protein
MNLHAPDI_03549 5.6e-164 yhcI S COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
MNLHAPDI_03550 1e-30 cspB K Cold-shock protein
MNLHAPDI_03551 4.4e-152 metQ M Belongs to the nlpA lipoprotein family
MNLHAPDI_03552 2.9e-196 yhcK 2.7.7.65 T COG2199 FOG GGDEF domain
MNLHAPDI_03553 6.3e-220 ydjN U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
MNLHAPDI_03554 7.6e-42 yhcM
MNLHAPDI_03555 1.3e-67 yhcN S Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
MNLHAPDI_03556 2.5e-167 yhcP
MNLHAPDI_03557 5.8e-99 yhcQ M Spore coat protein
MNLHAPDI_03558 0.0 yhcR 3.1.3.5, 3.1.31.1 F Belongs to the 5'-nucleotidase family
MNLHAPDI_03559 2.1e-103 yhcS 3.4.22.70 M COG3764 Sortase (surface protein transpeptidase)
MNLHAPDI_03560 7.3e-169 rluA 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
MNLHAPDI_03561 2.1e-67 yhcU S Family of unknown function (DUF5365)
MNLHAPDI_03562 9.9e-68 yhcV S COG0517 FOG CBS domain
MNLHAPDI_03563 1.3e-119 yhcW 5.4.2.6 S hydrolase
MNLHAPDI_03564 2.7e-304 yhcX 3.5.1.3 K Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
MNLHAPDI_03565 4.6e-260 yhxA E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MNLHAPDI_03566 5.2e-104 glpP K Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
MNLHAPDI_03567 5.7e-152 glpF G Belongs to the MIP aquaporin (TC 1.A.8) family
MNLHAPDI_03568 4.6e-293 glpK 2.7.1.30 C Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MNLHAPDI_03569 0.0 glpD 1.1.5.3 C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MNLHAPDI_03570 0.0 pmmB 5.4.2.2, 5.4.2.8 G Phosphoglucomutase
MNLHAPDI_03571 5.5e-214 yhcY 2.7.13.3 T Histidine kinase
MNLHAPDI_03572 1.7e-111 yhcZ K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MNLHAPDI_03573 3.2e-84 azr 1.7.1.6 S NADPH-dependent FMN reductase
MNLHAPDI_03574 1.2e-38 yhdB S YhdB-like protein
MNLHAPDI_03575 1.8e-53 yhdC S Protein of unknown function (DUF3889)
MNLHAPDI_03576 8.7e-188 cwlS 3.5.1.28 CBM50 M COG1388 FOG LysM repeat
MNLHAPDI_03577 1e-75 nsrR K Transcriptional regulator
MNLHAPDI_03578 1.3e-237 ygxB M Conserved TM helix
MNLHAPDI_03579 6.3e-276 ycgB S Stage V sporulation protein R
MNLHAPDI_03580 5.4e-256 phoB 3.1.3.1 P Belongs to the alkaline phosphatase family
MNLHAPDI_03581 8e-140 lytE 3.5.1.28 CBM50 M COG1388 FOG LysM repeat
MNLHAPDI_03582 8.4e-162 citR K Transcriptional regulator
MNLHAPDI_03583 5.9e-205 citA 2.3.3.1 C Belongs to the citrate synthase family
MNLHAPDI_03584 5.4e-161 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MNLHAPDI_03585 3.4e-250 yhdG E amino acid
MNLHAPDI_03586 5.7e-242 yhdH S Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
MNLHAPDI_03587 9.7e-269 ydeL K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
MNLHAPDI_03588 2e-76 BH1582 K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
MNLHAPDI_03589 8.1e-45 yhdK S Sigma-M inhibitor protein
MNLHAPDI_03590 6.6e-201 yhdL S Sigma factor regulator N-terminal
MNLHAPDI_03591 5.5e-86 sigM K Belongs to the sigma-70 factor family. ECF subfamily
MNLHAPDI_03592 1.3e-190 yhdN C Aldo keto reductase
MNLHAPDI_03593 3e-110 plsC 2.3.1.51 I Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family
MNLHAPDI_03594 3.1e-240 corC1 S COG1253 Hemolysins and related proteins containing CBS domains
MNLHAPDI_03595 4.1e-74 cueR K transcriptional
MNLHAPDI_03596 2.2e-221 yhdR 2.6.1.1 E Aminotransferase
MNLHAPDI_03597 3.9e-246 corC1 P COG1253 Hemolysins and related proteins containing CBS domains
MNLHAPDI_03598 1.7e-44 crcB D Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MNLHAPDI_03599 4.3e-65 crcB D Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MNLHAPDI_03600 6.2e-134 yhdW 3.1.4.46 C glycerophosphoryl diester phosphodiesterase
MNLHAPDI_03602 1.5e-203 yhdY M Mechanosensitive ion channel
MNLHAPDI_03603 1.2e-140 cobB K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form
MNLHAPDI_03604 1.7e-151 yheN G deacetylase
MNLHAPDI_03605 6.9e-153 dat 2.6.1.21 E Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha- keto acid in the first half-reaction
MNLHAPDI_03606 1.5e-229 nhaC C Na H antiporter
MNLHAPDI_03607 2.9e-83 nhaX T Belongs to the universal stress protein A family
MNLHAPDI_03608 0.0 yheI V COG1132 ABC-type multidrug transport system, ATPase and permease components
MNLHAPDI_03609 0.0 yheH V COG1132 ABC-type multidrug transport system, ATPase and permease components
MNLHAPDI_03610 5.8e-109 yheG GM NAD(P)H-binding
MNLHAPDI_03611 6.3e-28 sspB S spore protein
MNLHAPDI_03612 1.3e-36 yheE S Family of unknown function (DUF5342)
MNLHAPDI_03613 1.6e-268 gshB 6.3.2.2, 6.3.2.3 HJ YheC/D like ATP-grasp
MNLHAPDI_03614 7.4e-216 yheC HJ YheC/D like ATP-grasp
MNLHAPDI_03615 1.4e-201 yheB S Belongs to the UPF0754 family
MNLHAPDI_03616 9.5e-48 yheA S Belongs to the UPF0342 family
MNLHAPDI_03617 3.7e-204 yhaZ L DNA alkylation repair enzyme
MNLHAPDI_03618 4.3e-142 yhaX S haloacid dehalogenase-like hydrolase
MNLHAPDI_03619 7.9e-293 hemZ H coproporphyrinogen III oxidase
MNLHAPDI_03620 1.7e-208 yhaU P COG0475 Kef-type K transport systems, membrane components
MNLHAPDI_03621 7.8e-88 yhaT P regulatory, ligand-binding protein related to C-terminal domains of K channels
MNLHAPDI_03623 2.1e-132 yhaR 5.3.3.18 I enoyl-CoA hydratase
MNLHAPDI_03624 2.4e-26 S YhzD-like protein
MNLHAPDI_03625 1.8e-167 yhaQ S ABC transporter, ATP-binding protein
MNLHAPDI_03626 7.2e-215 yhaP CP COG1668 ABC-type Na efflux pump, permease component
MNLHAPDI_03627 1.6e-222 yhaO L DNA repair exonuclease
MNLHAPDI_03628 0.0 yhaN L AAA domain
MNLHAPDI_03629 1.5e-177 yhaM L Shows a 3'-5' exoribonuclease activity
MNLHAPDI_03630 1.6e-21 yhaL S Sporulation protein YhaL
MNLHAPDI_03631 1.9e-121 prsA 5.2.1.8 M plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins
MNLHAPDI_03632 8.7e-90 yhaK S Putative zincin peptidase
MNLHAPDI_03633 1.3e-54 yhaI S Protein of unknown function (DUF1878)
MNLHAPDI_03634 1e-113 hpr K Negative regulator of protease production and sporulation
MNLHAPDI_03635 2e-38 yhaH S YtxH-like protein
MNLHAPDI_03636 1.6e-20
MNLHAPDI_03637 3.6e-80 trpP S Tryptophan transporter TrpP
MNLHAPDI_03638 2.9e-204 serC 2.6.1.52 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MNLHAPDI_03639 4.7e-81 hit FG COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
MNLHAPDI_03640 8.8e-136 ecsA V transporter (ATP-binding protein)
MNLHAPDI_03641 1.7e-213 ecsB U ABC transporter
MNLHAPDI_03642 6.9e-114 ecsC S EcsC protein family
MNLHAPDI_03643 2.8e-229 yhaA 3.5.1.47 E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
MNLHAPDI_03644 1.4e-243 yhfA C membrane
MNLHAPDI_03645 1.6e-33 1.15.1.2 C Rubrerythrin
MNLHAPDI_03646 1.9e-89 traP 1.14.99.57, 6.2.1.3 S enzyme involved in biosynthesis of extracellular polysaccharides
MNLHAPDI_03647 0.0 pbpF 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
MNLHAPDI_03648 6.5e-201 hemE 4.1.1.37 H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MNLHAPDI_03649 1.8e-178 hemH 4.99.1.1, 4.99.1.9 H Catalyzes the ferrous insertion into protoporphyrin IX
MNLHAPDI_03650 1.5e-264 hemG 1.14.19.9, 1.3.3.15, 1.3.3.4 H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MNLHAPDI_03651 5.4e-101 yhgD K Transcriptional regulator
MNLHAPDI_03652 6e-215 yhgE S YhgE Pip N-terminal domain protein
MNLHAPDI_03653 3e-184 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MNLHAPDI_03654 9.8e-138 yhfC S Putative membrane peptidase family (DUF2324)
MNLHAPDI_03655 1.6e-199 yhfE 3.2.1.4 GH5,GH9 G peptidase M42
MNLHAPDI_03656 1.7e-72 3.4.13.21 S ASCH
MNLHAPDI_03657 3.8e-227 gltP C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
MNLHAPDI_03658 1.8e-141 yhfI S COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III
MNLHAPDI_03659 2e-191 lplJ 6.3.1.20 H Lipoate-protein ligase
MNLHAPDI_03660 2.6e-112 yhfK GM NmrA-like family
MNLHAPDI_03661 7.3e-302 fadD 6.2.1.3 IQ AMP-binding enzyme C-terminal domain
MNLHAPDI_03662 1.9e-65 yhfM
MNLHAPDI_03663 3.5e-241 yhfN 3.4.24.84 O Peptidase M48
MNLHAPDI_03664 5.6e-198 aprE 3.4.21.62 O Belongs to the peptidase S8 family
MNLHAPDI_03665 3.1e-75 VY92_01935 K acetyltransferase
MNLHAPDI_03666 5.4e-181 yhfP 1.1.1.1 C Quinone oxidoreductase
MNLHAPDI_03667 4.3e-159 yfmC M Periplasmic binding protein
MNLHAPDI_03668 1.9e-109 yhfR 3.1.3.73 G Belongs to the phosphoglycerate mutase family
MNLHAPDI_03669 5.5e-195 vraB 2.3.1.9 I Belongs to the thiolase family
MNLHAPDI_03670 6.4e-268 yhfT 6.2.1.3 IQ AMP-binding enzyme C-terminal domain
MNLHAPDI_03671 6.5e-91 bioY S BioY family
MNLHAPDI_03672 1.7e-182 hemAT NT chemotaxis protein
MNLHAPDI_03673 4.7e-301 yhfW CE COG0665 Glycine D-amino acid oxidases (deaminating)
MNLHAPDI_03674 1.6e-157 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MNLHAPDI_03675 1.3e-32 yhzC S IDEAL
MNLHAPDI_03676 4.2e-109 comK K Competence transcription factor
MNLHAPDI_03677 2.1e-168 IQ Enoyl-(Acyl carrier protein) reductase
MNLHAPDI_03678 2.8e-39 yhjA S Excalibur calcium-binding domain
MNLHAPDI_03679 2.3e-265 yhjB E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MNLHAPDI_03680 6.9e-27 yhjC S Protein of unknown function (DUF3311)
MNLHAPDI_03681 5e-60 yhjD
MNLHAPDI_03682 9.1e-110 yhjE S SNARE associated Golgi protein
MNLHAPDI_03683 1.2e-91 sipV 3.4.21.89 U Belongs to the peptidase S26 family
MNLHAPDI_03684 1.2e-280 yhjG CH FAD binding domain
MNLHAPDI_03685 4.5e-94 yhjH K helix_turn_helix multiple antibiotic resistance protein
MNLHAPDI_03686 3.8e-213 glcP G Major Facilitator Superfamily
MNLHAPDI_03687 6e-199 thuB 1.1.1.361 S Oxidoreductase family, C-terminal alpha/beta domain
MNLHAPDI_03688 2.6e-160 ntdB 3.1.3.92 S Sucrose-6F-phosphate phosphohydrolase
MNLHAPDI_03689 1.8e-253 ntdA 2.6.1.104 E Belongs to the DegT DnrJ EryC1 family
MNLHAPDI_03690 1.7e-187 yhjM 5.1.1.1 K Transcriptional regulator
MNLHAPDI_03691 1.9e-201 abrB S membrane
MNLHAPDI_03692 9e-215 EGP Transmembrane secretion effector
MNLHAPDI_03693 0.0 S Sugar transport-related sRNA regulator N-term
MNLHAPDI_03694 1.1e-77 yhjR S Rubrerythrin
MNLHAPDI_03695 0.0 addB 3.1.21.3, 3.6.4.12 L ATP-dependent helicase deoxyribonuclease subunit B
MNLHAPDI_03696 0.0 addA 3.6.4.12 L ATP-dependent helicase nuclease subunit A
MNLHAPDI_03697 6.9e-220 sbcD L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
MNLHAPDI_03698 0.0 sbcC L COG0419 ATPase involved in DNA repair
MNLHAPDI_03699 1.1e-49 yisB V COG1403 Restriction endonuclease
MNLHAPDI_03700 4.5e-32 gerPF S Spore germination protein gerPA/gerPF
MNLHAPDI_03701 3e-66 gerPE S Spore germination protein GerPE
MNLHAPDI_03702 6.3e-24 gerPD S Spore germination protein
MNLHAPDI_03703 1.8e-54 gerPC S Spore germination protein
MNLHAPDI_03704 4e-34 gerPB S cell differentiation
MNLHAPDI_03705 1.9e-33 gerPA S Spore germination protein
MNLHAPDI_03706 1.5e-22 yisI S Spo0E like sporulation regulatory protein
MNLHAPDI_03707 1.1e-172 cotH M Spore Coat
MNLHAPDI_03708 7.1e-172 yisK Q COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)
MNLHAPDI_03709 3.9e-57 yisL S UPF0344 protein
MNLHAPDI_03710 0.0 wprA O Belongs to the peptidase S8 family
MNLHAPDI_03711 1.3e-102 yisN S Protein of unknown function (DUF2777)
MNLHAPDI_03712 0.0 asnO 6.3.5.4 E Asparagine synthase
MNLHAPDI_03713 6.4e-88 yizA S Damage-inducible protein DinB
MNLHAPDI_03714 1.7e-148 crtB 2.5.1.21, 2.5.1.32, 2.5.1.99 I phytoene
MNLHAPDI_03715 1.5e-242 yisQ V Mate efflux family protein
MNLHAPDI_03716 1.2e-160 yisR K Transcriptional regulator
MNLHAPDI_03717 2.4e-184 purR K helix_turn _helix lactose operon repressor
MNLHAPDI_03718 4.5e-199 yisS 1.1.1.370 S Oxidoreductase family, C-terminal alpha/beta domain
MNLHAPDI_03719 1.3e-93 yisT S DinB family
MNLHAPDI_03720 1.9e-107 argO S Lysine exporter protein LysE YggA
MNLHAPDI_03721 5.5e-275 yisV K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
MNLHAPDI_03722 2e-35 mcbG S Pentapeptide repeats (9 copies)
MNLHAPDI_03723 9.1e-155 yisY I hydrolases or acyltransferases (alpha beta hydrolase superfamily)
MNLHAPDI_03724 4.2e-112 cysC 1.8.4.10, 1.8.4.8, 2.7.1.25, 2.7.7.4 P Catalyzes the synthesis of activated sulfate
MNLHAPDI_03725 7.9e-232 sat 2.7.7.4 P Belongs to the sulfate adenylyltransferase family
MNLHAPDI_03726 8.6e-141 cysH 1.8.4.10, 1.8.4.8, 2.7.1.25 EH Belongs to the PAPS reductase family. CysH subfamily
MNLHAPDI_03727 1.6e-120 comB 3.1.3.71 H Belongs to the ComB family
MNLHAPDI_03728 5.4e-141 yitD 4.4.1.19 S synthase
MNLHAPDI_03729 1.7e-108 yitE S Uncharacterised 5xTM membrane BCR, YitT family COG1284
MNLHAPDI_03730 5.4e-222 yitF 5.5.1.27 M Belongs to the mandelate racemase muconate lactonizing enzyme family
MNLHAPDI_03731 1.5e-228 yitG EGP Major facilitator Superfamily
MNLHAPDI_03732 2e-160 yitH K Acetyltransferase (GNAT) domain
MNLHAPDI_03733 7.8e-79 yjcF S Acetyltransferase (GNAT) domain
MNLHAPDI_03734 0.0 yitJ 1.5.1.20, 2.1.1.10, 2.1.1.13 E Catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine
MNLHAPDI_03735 5.6e-54 yajQ S Belongs to the UPF0234 family
MNLHAPDI_03736 6.9e-161 cvfB S protein conserved in bacteria
MNLHAPDI_03737 8.5e-94
MNLHAPDI_03738 1.4e-170
MNLHAPDI_03739 1.5e-97 S Sporulation delaying protein SdpA
MNLHAPDI_03740 1.5e-58 K Transcriptional regulator PadR-like family
MNLHAPDI_03741 2e-95
MNLHAPDI_03742 1.4e-44 yitR S Domain of unknown function (DUF3784)
MNLHAPDI_03743 2.2e-311 nprB 3.4.24.28 E Peptidase M4
MNLHAPDI_03744 8.4e-159 yitS S protein conserved in bacteria
MNLHAPDI_03745 6.6e-148 yitT S Uncharacterized protein conserved in bacteria (DUF2179)
MNLHAPDI_03746 5e-73 ipi S Intracellular proteinase inhibitor
MNLHAPDI_03747 1.2e-17 S Protein of unknown function (DUF3813)
MNLHAPDI_03748 7.8e-154 yitU 3.1.3.104 S hydrolases of the HAD superfamily
MNLHAPDI_03749 1e-142 yjfP S COG1073 Hydrolases of the alpha beta superfamily
MNLHAPDI_03750 4.7e-51 yitW S metal-sulfur cluster biosynthetic enzyme
MNLHAPDI_03751 1.5e-22 pilT S Proteolipid membrane potential modulator
MNLHAPDI_03752 6e-266 yitY C D-arabinono-1,4-lactone oxidase
MNLHAPDI_03753 1.7e-88 norB G Major Facilitator Superfamily
MNLHAPDI_03754 1.2e-196 argC 1.2.1.38 E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MNLHAPDI_03755 1.3e-229 argJ 2.3.1.1, 2.3.1.35, 2.7.2.8 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MNLHAPDI_03756 4.1e-136 argB 2.7.2.8 E Belongs to the acetylglutamate kinase family. ArgB subfamily
MNLHAPDI_03757 6e-216 argD 2.6.1.11, 2.6.1.17 E acetylornithine aminotransferase
MNLHAPDI_03758 9.7e-205 carA 6.3.5.5 F Carbamoyl-phosphate synthetase glutamine chain
MNLHAPDI_03759 0.0 carB 6.3.5.5 EF Carbamoyl-phosphate synthetase ammonia chain
MNLHAPDI_03760 1.5e-175 argF 2.1.3.3 E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MNLHAPDI_03761 9.5e-28 yjzC S YjzC-like protein
MNLHAPDI_03762 2.3e-16 yjzD S Protein of unknown function (DUF2929)
MNLHAPDI_03763 6.8e-141 yjaU I carboxylic ester hydrolase activity
MNLHAPDI_03764 1.8e-101 yjaV
MNLHAPDI_03765 1.1e-183 med S Transcriptional activator protein med
MNLHAPDI_03766 4.7e-25 comZ S ComZ
MNLHAPDI_03767 2.7e-22 yjzB
MNLHAPDI_03768 3.9e-173 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MNLHAPDI_03769 1.8e-234 fabF 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
MNLHAPDI_03770 7.8e-151 yjaZ O Zn-dependent protease
MNLHAPDI_03771 1.8e-184 appD P Belongs to the ABC transporter superfamily
MNLHAPDI_03772 6.5e-187 appF E Belongs to the ABC transporter superfamily
MNLHAPDI_03773 1.6e-251 appA E COG0747 ABC-type dipeptide transport system, periplasmic component
MNLHAPDI_03774 1.3e-171 oppB P COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
MNLHAPDI_03775 7.9e-163 appC EP COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
MNLHAPDI_03776 6.5e-147 yjbA S Belongs to the UPF0736 family
MNLHAPDI_03777 6.1e-185 trpS 6.1.1.2 J Tryptophanyl-tRNA synthetase
MNLHAPDI_03778 3e-165 oppA E ABC transporter substrate-binding protein
MNLHAPDI_03779 6.3e-116 oppA E ABC transporter substrate-binding protein
MNLHAPDI_03780 2.7e-166 oppB P COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
MNLHAPDI_03781 7.7e-166 oppC EP COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
MNLHAPDI_03782 1.5e-197 oppD P Belongs to the ABC transporter superfamily
MNLHAPDI_03783 5.5e-172 oppF E Belongs to the ABC transporter superfamily
MNLHAPDI_03784 1.8e-210 yjbB EGP Major Facilitator Superfamily
MNLHAPDI_03785 2.6e-103 yjbC K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
MNLHAPDI_03786 3.5e-67 spxA 1.20.4.1 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
MNLHAPDI_03787 6e-112 yjbE P Integral membrane protein TerC family
MNLHAPDI_03788 2.3e-116 mecA NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC
MNLHAPDI_03789 2.1e-221 yjbF S Competence protein
MNLHAPDI_03790 0.0 pepF E oligoendopeptidase F
MNLHAPDI_03791 1.8e-20
MNLHAPDI_03793 1.2e-168 yjbH Q dithiol-disulfide isomerase involved in polyketide biosynthesis
MNLHAPDI_03794 1.1e-71 yjbI S Bacterial-like globin
MNLHAPDI_03795 3.8e-83 yjbJ M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)
MNLHAPDI_03796 1e-99 yjbK S protein conserved in bacteria
MNLHAPDI_03797 1.6e-61 yjbL S Belongs to the UPF0738 family
MNLHAPDI_03798 2.6e-112 yjbM 2.7.6.5 S GTP pyrophosphokinase
MNLHAPDI_03799 2.1e-151 nadK 2.7.1.23 G Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MNLHAPDI_03800 2.6e-158 yjbO 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
MNLHAPDI_03801 3e-128 prpE 3.1.3.16, 3.6.1.41 T Asymmetrically hydrolyzes Ap4p to yield AMP and ATP
MNLHAPDI_03802 0.0 yjbQ P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
MNLHAPDI_03803 3.4e-137 tenA 3.5.99.2 K Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MNLHAPDI_03804 9.3e-107 tenI 2.5.1.3, 5.3.99.10 H Transcriptional regulator TenI
MNLHAPDI_03805 1.2e-213 thiO 1.4.3.19 E Glycine oxidase
MNLHAPDI_03806 2.6e-29 thiS H thiamine diphosphate biosynthetic process
MNLHAPDI_03807 1.5e-135 thiG 2.8.1.10 H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S
MNLHAPDI_03808 5.1e-187 thiF 2.7.7.73, 2.7.7.80 H COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
MNLHAPDI_03809 2.2e-148 thiD 2.5.1.3, 2.7.1.35, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Phosphomethylpyrimidine kinase
MNLHAPDI_03810 9.5e-141 fabI 1.3.1.10, 1.3.1.9 I Enoyl- acyl-carrier-protein reductase NADH
MNLHAPDI_03811 5.9e-54 yjbX S Spore coat protein
MNLHAPDI_03812 4.4e-82 cotZ S Spore coat protein
MNLHAPDI_03813 7.6e-96 cotY S Spore coat protein Z
MNLHAPDI_03814 1.6e-72 cotX S Spore Coat Protein X and V domain
MNLHAPDI_03815 8.8e-24 cotW
MNLHAPDI_03816 1.1e-54 cotV S Spore Coat Protein X and V domain
MNLHAPDI_03817 4.3e-56 yjcA S Protein of unknown function (DUF1360)
MNLHAPDI_03820 2.9e-38 spoVIF S Stage VI sporulation protein F
MNLHAPDI_03821 0.0 yjcD 3.6.4.12 L DNA helicase
MNLHAPDI_03822 1.7e-38
MNLHAPDI_03823 6.6e-72 yjcF S COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
MNLHAPDI_03824 2.9e-93 yjcG J Belongs to the 2H phosphoesterase superfamily. YjcG family
MNLHAPDI_03825 2.6e-137 yjcH P COG2382 Enterochelin esterase and related enzymes
MNLHAPDI_03826 3.2e-214 metB 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
MNLHAPDI_03827 4.2e-217 metC 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
MNLHAPDI_03828 5e-96 rimJ 2.3.1.128 J Alanine acetyltransferase
MNLHAPDI_03829 5.4e-212 yjcL S Protein of unknown function (DUF819)
MNLHAPDI_03832 2.1e-190 S Putative amidase domain
MNLHAPDI_03833 2.6e-44 yjcN
MNLHAPDI_03836 8.5e-81 L Transposase
MNLHAPDI_03837 1.6e-72 yjcP
MNLHAPDI_03838 4.1e-49 S YjcQ protein
MNLHAPDI_03839 1.1e-92 yqaS L DNA packaging
MNLHAPDI_03840 2.2e-47 yjcS S Antibiotic biosynthesis monooxygenase
MNLHAPDI_03841 2.4e-141 IQ Enoyl-(Acyl carrier protein) reductase
MNLHAPDI_03843 0.0 manR 2.7.1.200, 2.7.1.202 GKT transcriptional antiterminator
MNLHAPDI_03844 0.0 manP 2.7.1.191, 2.7.1.202 G phosphotransferase system
MNLHAPDI_03845 6.7e-189 manA 5.3.1.8 G mannose-6-phosphate isomerase
MNLHAPDI_03846 4.8e-51 yjdF S Protein of unknown function (DUF2992)
MNLHAPDI_03847 2.5e-94 yjdG 2.3.1.128 J Acetyltransferase (GNAT) domain
MNLHAPDI_03849 8e-82 ybaK S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MNLHAPDI_03850 4.2e-29 S Domain of unknown function (DUF4177)
MNLHAPDI_03851 2.7e-52 yjdJ S Domain of unknown function (DUF4306)
MNLHAPDI_03852 3.3e-175 cyoE 2.5.1.141 O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
MNLHAPDI_03854 4.9e-265 xynD 3.5.1.104 G Polysaccharide deacetylase
MNLHAPDI_03855 5.5e-83 S Protein of unknown function (DUF2690)
MNLHAPDI_03856 3.6e-21 yjfB S Putative motility protein
MNLHAPDI_03857 1.6e-171 yjfC O Predicted Zn-dependent protease (DUF2268)
MNLHAPDI_03858 1.2e-45 T PhoQ Sensor
MNLHAPDI_03859 8.9e-104 yjgB S Domain of unknown function (DUF4309)
MNLHAPDI_03860 0.0 yjgC 1.17.1.10, 1.17.1.9 C formate dehydrogenase (NAD+) activity
MNLHAPDI_03861 5.7e-95 yjgD S Protein of unknown function (DUF1641)
MNLHAPDI_03862 1.5e-06 S Domain of unknown function (DUF4352)
MNLHAPDI_03863 1.9e-115 yjhB 3.6.1.13, 3.6.1.55 F ADP-ribose pyrophosphatase
MNLHAPDI_03865 1.8e-220 yjiB 1.14.13.154, 1.14.15.8 C Cytochrome P450
MNLHAPDI_03866 3.2e-217 oleD GT1 CG COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase
MNLHAPDI_03867 8.2e-30
MNLHAPDI_03868 1.2e-146 hemD 2.1.1.107, 4.2.1.75 H Uroporphyrinogen-III synthase
MNLHAPDI_03869 1.9e-122 ybbM S transport system, permease component
MNLHAPDI_03870 5.2e-136 pstB 3.6.3.27 P ATPases associated with a variety of cellular activities
MNLHAPDI_03871 1.8e-176 yjlA EG Putative multidrug resistance efflux transporter
MNLHAPDI_03872 2.8e-93 yjlB S Cupin domain
MNLHAPDI_03873 7.1e-66 yjlC S Protein of unknown function (DUF1641)
MNLHAPDI_03874 2.6e-219 yjlD 1.6.99.3 C NADH dehydrogenase
MNLHAPDI_03875 6.3e-284 uxaC 5.3.1.12 G glucuronate isomerase
MNLHAPDI_03876 5.8e-250 yjmB G symporter YjmB
MNLHAPDI_03877 4.3e-194 yjmC 1.1.1.350 C Belongs to the LDH2 MDH2 oxidoreductase family
MNLHAPDI_03878 1.6e-193 rspB 1.1.1.380 E Alcohol dehydrogenase GroES-like domain
MNLHAPDI_03879 4.7e-215 uxuA 4.2.1.8 G Catalyzes the dehydration of D-mannonate
MNLHAPDI_03880 2.3e-153 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
MNLHAPDI_03881 3.7e-227 exuT G Sugar (and other) transporter
MNLHAPDI_03882 2.3e-184 exuR K transcriptional
MNLHAPDI_03883 2.1e-287 uxaB 1.1.1.17, 1.1.1.58 G tagaturonate reductase activity
MNLHAPDI_03884 4.6e-285 uxaA 4.2.1.7, 4.4.1.24 G Altronate
MNLHAPDI_03885 7.4e-130 MA20_18170 S membrane transporter protein
MNLHAPDI_03886 2.3e-78 yjoA S DinB family
MNLHAPDI_03887 9.4e-247 ftsH2 3.4.21.53 O AAA domain (dynein-related subfamily)
MNLHAPDI_03888 1e-212 S response regulator aspartate phosphatase
MNLHAPDI_03890 6.3e-41 S YCII-related domain
MNLHAPDI_03891 2.9e-168 xlyA 3.5.1.28 CBM50 M N-acetylmuramoyl-L-alanine amidase
MNLHAPDI_03892 1.8e-60 yjqA S Bacterial PH domain
MNLHAPDI_03893 2.1e-111 yjqB S Pfam:DUF867
MNLHAPDI_03894 4.4e-160 ydbD P Catalase
MNLHAPDI_03895 4.3e-109 xkdA E IrrE N-terminal-like domain
MNLHAPDI_03896 1.6e-55 xre K Helix-turn-helix XRE-family like proteins
MNLHAPDI_03898 5e-156 xkdB K sequence-specific DNA binding
MNLHAPDI_03899 9.2e-118 xkdC L Bacterial dnaA protein
MNLHAPDI_03902 4.6e-10 yqaO S Phage-like element PBSX protein XtrA
MNLHAPDI_03903 2.2e-82 xpf K COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog
MNLHAPDI_03904 5.3e-139 xtmA L phage terminase small subunit
MNLHAPDI_03905 1.4e-253 xtmB S phage terminase, large subunit
MNLHAPDI_03906 6e-285 yqbA S portal protein
MNLHAPDI_03907 3.5e-133 yqbD 2.1.1.72 L Putative phage serine protease XkdF
MNLHAPDI_03908 1.3e-168 xkdG S Phage capsid family
MNLHAPDI_03909 5.5e-65 yqbG S Protein of unknown function (DUF3199)
MNLHAPDI_03910 8.7e-65 yqbH S Domain of unknown function (DUF3599)
MNLHAPDI_03911 4.4e-88 xkdI S Bacteriophage HK97-gp10, putative tail-component
MNLHAPDI_03912 1.9e-77 xkdJ
MNLHAPDI_03913 2.5e-256 xkdK S Phage tail sheath C-terminal domain
MNLHAPDI_03914 6.1e-76 xkdM S Phage tail tube protein
MNLHAPDI_03915 1.9e-77 S Phage XkdN-like tail assembly chaperone protein, TAC
MNLHAPDI_03916 0.0 xkdO L Transglycosylase SLT domain
MNLHAPDI_03917 3.7e-122 xkdP S Lysin motif
MNLHAPDI_03918 4.8e-182 yqbQ 3.2.1.96 G NLP P60 protein
MNLHAPDI_03919 2.1e-39 xkdR S Protein of unknown function (DUF2577)
MNLHAPDI_03920 9.6e-71 xkdS S Protein of unknown function (DUF2634)
MNLHAPDI_03921 6e-191 xkdT S Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MNLHAPDI_03922 4e-104 xkdU S Uncharacterised protein conserved in bacteria (DUF2313)
MNLHAPDI_03923 6.7e-41
MNLHAPDI_03924 0.0
MNLHAPDI_03925 2.6e-55 xkdW S XkdW protein
MNLHAPDI_03926 1.7e-23 xkdX
MNLHAPDI_03927 2.8e-154 xepA
MNLHAPDI_03928 2.8e-39 xhlA S Haemolysin XhlA
MNLHAPDI_03929 9.3e-40 xhlB S SPP1 phage holin
MNLHAPDI_03930 1.2e-163 xlyA 3.5.1.28 M n-acetylmuramoyl-L-alanine amidase
MNLHAPDI_03931 6.7e-23 spoIISB S Stage II sporulation protein SB
MNLHAPDI_03932 1.8e-136 spoIISA S Toxin SpoIISA, type II toxin-antitoxin system
MNLHAPDI_03933 5.8e-175 pit P phosphate transporter
MNLHAPDI_03934 6.9e-110 ykaA P COG1392 Phosphate transport regulator (distant homolog of PhoU)
MNLHAPDI_03935 9.4e-242 steT E amino acid
MNLHAPDI_03936 7.2e-183 mhqA E COG0346 Lactoylglutathione lyase and related lyases
MNLHAPDI_03938 0.0 ykcB M COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MNLHAPDI_03939 1.3e-179 ykcC GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
MNLHAPDI_03941 2.5e-213 htrA 3.4.21.107 O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MNLHAPDI_03942 3.7e-135 proG 1.5.1.2 E Pyrroline-5-carboxylate reductase
MNLHAPDI_03943 1.1e-152 dppA E D-aminopeptidase
MNLHAPDI_03944 1.1e-159 dppB P COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
MNLHAPDI_03945 3.6e-174 dppC EP COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
MNLHAPDI_03946 1.9e-186 dppD P Belongs to the ABC transporter superfamily
MNLHAPDI_03947 0.0 dppE E ABC transporter substrate-binding protein
MNLHAPDI_03949 1.2e-177 ykfA 3.4.17.13 V proteins, homologs of microcin C7 resistance protein MccF
MNLHAPDI_03950 7.5e-200 ykfB 5.1.1.20 M Belongs to the mandelate racemase muconate lactonizing enzyme family
MNLHAPDI_03951 2.2e-165 ykfC 3.4.14.13 M COG0791 Cell wall-associated hydrolases (invasion-associated proteins)
MNLHAPDI_03952 9.4e-186 ykfD E Belongs to the ABC transporter superfamily
MNLHAPDI_03953 5.3e-203 pgl 3.1.1.31 G 6-phosphogluconolactonase
MNLHAPDI_03954 2e-160 ykgA E Amidinotransferase
MNLHAPDI_03955 3.4e-92 ykhA 3.1.2.20 I Acyl-CoA hydrolase
MNLHAPDI_03956 5.8e-222 hmp 1.14.12.17 C Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MNLHAPDI_03957 7.2e-09
MNLHAPDI_03958 2.7e-129 ykjA S Protein of unknown function (DUF421)
MNLHAPDI_03959 5.7e-97 ykkA S Protein of unknown function (DUF664)
MNLHAPDI_03960 1.7e-98 ykkB 2.3.1.128 J COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
MNLHAPDI_03961 3.5e-55 ykkC P Multidrug resistance protein
MNLHAPDI_03962 7e-50 ykkD P Multidrug resistance protein
MNLHAPDI_03963 6.6e-170 purU 2.7.7.72, 3.5.1.10 F Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)
MNLHAPDI_03964 5.2e-201 proB 2.7.2.11 E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MNLHAPDI_03965 5.3e-226 proA 1.2.1.41, 1.2.1.81 E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MNLHAPDI_03966 1.3e-70 ohrA O Organic hydroperoxide resistance protein
MNLHAPDI_03967 4.8e-73 ohrR K COG1846 Transcriptional regulators
MNLHAPDI_03968 8.4e-72 ohrB O Organic hydroperoxide resistance protein
MNLHAPDI_03970 2.8e-87 guaD 3.5.4.12, 3.5.4.3, 3.5.4.33 FJ COG0590 Cytosine adenosine deaminases
MNLHAPDI_03971 0.0 metE 2.1.1.14 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MNLHAPDI_03972 5e-176 isp O Belongs to the peptidase S8 family
MNLHAPDI_03973 1.8e-150 T COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
MNLHAPDI_03974 5.3e-136 ykoC P Cobalt transport protein
MNLHAPDI_03975 7.2e-308 P ABC transporter, ATP-binding protein
MNLHAPDI_03976 6.9e-99 ykoE S ABC-type cobalt transport system, permease component
MNLHAPDI_03977 1.1e-109 ykoF S YKOF-related Family
MNLHAPDI_03978 2.4e-124 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MNLHAPDI_03979 8.3e-241 ykoH 2.7.13.3 T Histidine kinase
MNLHAPDI_03980 2.1e-112 ykoI S Peptidase propeptide and YPEB domain
MNLHAPDI_03981 2.2e-85 ykoJ S Peptidase propeptide and YPEB domain
MNLHAPDI_03984 2.2e-222 mgtE P Acts as a magnesium transporter
MNLHAPDI_03985 1.4e-53 tnrA K transcriptional
MNLHAPDI_03986 5.9e-18
MNLHAPDI_03987 6.9e-26 ykoL
MNLHAPDI_03988 1.3e-81 mhqR K transcriptional
MNLHAPDI_03989 2.9e-60 ugtP 2.4.1.315 GT28 M COG0707 UDP-N-acetylglucosamine LPS N-acetylglucosamine transferase
MNLHAPDI_03990 6.1e-129 ugtP 2.4.1.315 GT28 M COG0707 UDP-N-acetylglucosamine LPS N-acetylglucosamine transferase
MNLHAPDI_03991 1.1e-98 ykoP G polysaccharide deacetylase
MNLHAPDI_03992 2.1e-154 ykoQ S Calcineurin-like phosphoesterase superfamily domain
MNLHAPDI_03993 0.0 ykoS
MNLHAPDI_03994 2.1e-185 ykoT GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
MNLHAPDI_03995 0.0 ligD 6.5.1.1 L ATP-dependent DNA ligase
MNLHAPDI_03996 3.6e-160 ku L With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
MNLHAPDI_03997 0.0 ydcR 2.7.7.65 T Diguanylate cyclase
MNLHAPDI_03998 3.5e-109 ykoX S membrane-associated protein
MNLHAPDI_03999 4.6e-177 ykoY P COG0861 Membrane protein TerC, possibly involved in tellurium resistance
MNLHAPDI_04000 9.5e-130 sigI K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MNLHAPDI_04001 8.2e-117 rsgI S Anti-sigma factor N-terminus
MNLHAPDI_04002 1.9e-26 sspD S small acid-soluble spore protein
MNLHAPDI_04003 7.3e-124 ykrK S Domain of unknown function (DUF1836)
MNLHAPDI_04004 3.5e-155 htpX O Belongs to the peptidase M48B family
MNLHAPDI_04005 3.7e-233 ktrB P COG0168 Trk-type K transport systems, membrane components
MNLHAPDI_04006 1.2e-10 ydfR S Protein of unknown function (DUF421)
MNLHAPDI_04007 1.4e-18 ykzE
MNLHAPDI_04008 1.4e-189 ykrP G COG3594 Fucose 4-O-acetylase and related acetyltransferases
MNLHAPDI_04009 0.0 kinE 2.7.13.3 T Histidine kinase
MNLHAPDI_04010 3.9e-87 ogt 2.1.1.63 L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MNLHAPDI_04012 2.2e-196 mtnA 5.3.1.23 E Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MNLHAPDI_04013 1.2e-227 mtnK 2.7.1.100 F Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
MNLHAPDI_04014 1.7e-150 mtnU 3.5.1.3 S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
MNLHAPDI_04015 1.1e-231 mtnE 2.6.1.83 E Aminotransferase
MNLHAPDI_04016 1.3e-229 mtnW 5.3.2.5 G Catalyzes the enolization of 2,3-diketo-5- methylthiopentyl-1-phosphate (DK-MTP-1-P) into 2-hydroxy-3-keto-5- methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P)
MNLHAPDI_04017 1.4e-135 mtnX 3.1.3.87, 4.2.1.109 E Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
MNLHAPDI_04018 1.6e-114 mtnB 3.1.3.87, 4.1.2.17, 4.2.1.109, 5.1.3.4 E Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P)
MNLHAPDI_04019 8.4e-96 mtnD 1.13.11.53, 1.13.11.54 S Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
MNLHAPDI_04020 2.2e-51 XK27_09985 S Protein of unknown function (DUF1232)
MNLHAPDI_04021 6.4e-09 S Spo0E like sporulation regulatory protein
MNLHAPDI_04022 1.4e-64 eag
MNLHAPDI_04023 1.6e-274 kinD 2.7.13.3 T COG0642 Signal transduction histidine kinase
MNLHAPDI_04024 1.3e-75 ykvE K transcriptional
MNLHAPDI_04025 2.5e-125 motB N Flagellar motor protein
MNLHAPDI_04026 1e-137 motA N flagellar motor
MNLHAPDI_04027 0.0 clpE O Belongs to the ClpA ClpB family
MNLHAPDI_04028 8.7e-182 ykvI S membrane
MNLHAPDI_04029 7.3e-126 queC 6.3.4.20 F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MNLHAPDI_04030 2.8e-81 queD 4.1.2.50, 4.2.3.12 H synthase
MNLHAPDI_04031 1.3e-139 queE 1.97.1.4, 4.3.99.3 H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
MNLHAPDI_04032 2e-96 queF 1.7.1.13 S Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MNLHAPDI_04033 3.8e-60 ykvN K HxlR-like helix-turn-helix
MNLHAPDI_04034 2.4e-133 IQ Enoyl-(Acyl carrier protein) reductase
MNLHAPDI_04035 9.9e-216 ykvP 3.5.1.28 M Glycosyl transferases group 1
MNLHAPDI_04036 3.5e-35 3.5.1.104 M LysM domain
MNLHAPDI_04037 1.4e-162 G Glycosyl hydrolases family 18
MNLHAPDI_04038 5.6e-46 ykvR S Protein of unknown function (DUF3219)
MNLHAPDI_04039 6e-25 ykvS S protein conserved in bacteria
MNLHAPDI_04040 2.8e-28
MNLHAPDI_04041 3.1e-102 ykvT 3.5.1.28 M Cell Wall Hydrolase
MNLHAPDI_04042 3.8e-238 ykvU S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
MNLHAPDI_04043 9.2e-89 stoA CO thiol-disulfide
MNLHAPDI_04044 0.0 cadA 3.6.3.3, 3.6.3.5 P COG2217 Cation transport ATPase
MNLHAPDI_04045 2.3e-09
MNLHAPDI_04046 1.3e-207 pepQ 3.4.13.9 E COG0006 Xaa-Pro aminopeptidase
MNLHAPDI_04047 6.4e-179 ykvZ 5.1.1.1 K Transcriptional regulator
MNLHAPDI_04049 2.2e-127 glcT K antiterminator
MNLHAPDI_04050 0.0 ptsG 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
MNLHAPDI_04051 2.1e-39 ptsH G phosphocarrier protein HPr
MNLHAPDI_04052 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MNLHAPDI_04053 7.2e-39 splA S Transcriptional regulator
MNLHAPDI_04054 7.5e-202 splB 4.1.99.14 L Spore photoproduct lyase
MNLHAPDI_04055 4.9e-128 ykwB 2.3.1.1 K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
MNLHAPDI_04056 1.6e-261 mcpC NT chemotaxis protein
MNLHAPDI_04057 5e-159 glxR 1.1.1.31, 1.1.1.60 I COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases
MNLHAPDI_04058 8e-124 ykwD J protein with SCP PR1 domains
MNLHAPDI_04059 0.0 mrdA 3.4.16.4 M Penicillin-binding Protein
MNLHAPDI_04060 0.0 pilS 2.7.13.3 T Histidine kinase
MNLHAPDI_04061 8e-224 patA 2.6.1.1 E Aminotransferase
MNLHAPDI_04062 2.2e-15
MNLHAPDI_04063 1.6e-168 cheV 2.7.13.3 T Chemotaxis protein CheV
MNLHAPDI_04064 1.7e-84 ykyB S YkyB-like protein
MNLHAPDI_04065 1.7e-235 ykuC EGP Major facilitator Superfamily
MNLHAPDI_04066 1.5e-86 ykuD S protein conserved in bacteria
MNLHAPDI_04067 1.6e-165 ykuE S Metallophosphoesterase
MNLHAPDI_04068 2.2e-142 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MNLHAPDI_04069 0.0 3.2.1.132 M Putative peptidoglycan binding domain

eggNOG-mapper v2 (Database: eggNOG v5.0, Jul. 2018 release)