ORF_ID e_value Gene_name EC_number CAZy COGs Description
COPIEHFA_00001 1.1e-256 dnaA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
COPIEHFA_00002 4.5e-200 dnaN 2.7.7.7 L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
COPIEHFA_00003 1.1e-29 yyzM S Protein conserved in bacteria
COPIEHFA_00004 8.6e-204 ychF J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
COPIEHFA_00005 4e-104 pth 3.1.1.29 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
COPIEHFA_00006 8e-94 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
COPIEHFA_00007 0.0 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
COPIEHFA_00008 1.7e-39 yabO J Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
COPIEHFA_00009 2.7e-61 divIC D Septum formation initiator
COPIEHFA_00011 5.1e-240 XK27_09285 3.5.2.6 V Beta-lactamase enzyme family
COPIEHFA_00012 7.2e-239 tilS 2.4.2.8, 6.3.4.19 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
COPIEHFA_00013 1.7e-96 hpt 2.4.2.8, 6.3.4.19 F Belongs to the purine pyrimidine phosphoribosyltransferase family
COPIEHFA_00014 0.0 ftsH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
COPIEHFA_00015 3.8e-103 L Transposase
COPIEHFA_00016 4e-50 L Transposase
COPIEHFA_00017 1.9e-46 L transposase activity
COPIEHFA_00018 2.5e-23 L Transposase
COPIEHFA_00019 4.2e-29 L transposition
COPIEHFA_00032 5.3e-11
COPIEHFA_00038 5.5e-139 mreC M Involved in formation and maintenance of cell shape
COPIEHFA_00039 6.3e-88 mreD M Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
COPIEHFA_00040 1.7e-90 usp 3.5.1.28 CBM50 S CHAP domain
COPIEHFA_00041 1.2e-174 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
COPIEHFA_00042 2.9e-218 araT 2.6.1.1 E Aminotransferase
COPIEHFA_00043 7e-144 recO L Involved in DNA repair and RecF pathway recombination
COPIEHFA_00044 1.3e-179 plsX 2.3.1.15 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
COPIEHFA_00045 4.2e-34 acpP1 IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
COPIEHFA_00046 2e-129 purC 4.1.1.21, 4.3.2.2, 6.3.2.6 F Belongs to the SAICAR synthetase family
COPIEHFA_00047 0.0 purL 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
COPIEHFA_00048 4.9e-276 purF 2.4.2.14 F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
COPIEHFA_00049 2e-183 purM 6.3.3.1, 6.3.4.13 F Phosphoribosylformylglycinamidine cyclo-ligase
COPIEHFA_00050 1.4e-101 purN 2.1.2.2 F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
COPIEHFA_00051 2.3e-295 purH 2.1.2.3, 3.5.4.10 F Bifunctional purine biosynthesis protein PurH
COPIEHFA_00052 6.1e-79 L transposase activity
COPIEHFA_00053 1.3e-49 L transposition
COPIEHFA_00054 6.3e-34 L Integrase core domain protein
COPIEHFA_00055 1.2e-160 S CHAP domain
COPIEHFA_00056 2.6e-241 purD 6.3.4.13 F Belongs to the GARS family
COPIEHFA_00057 4.9e-76 purE 5.4.99.18 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
COPIEHFA_00058 2.2e-204 purK 6.3.4.18 F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
COPIEHFA_00059 9.2e-141 1.1.1.169 H Ketopantoate reductase
COPIEHFA_00060 2.5e-247 purB 4.3.2.2 F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
COPIEHFA_00061 0.0 argS 6.1.1.19 J Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
COPIEHFA_00062 8.2e-70 argR K Regulates arginine biosynthesis genes
COPIEHFA_00063 1e-57 ymcA 3.6.3.21 S Belongs to the UPF0342 family
COPIEHFA_00064 0.0 mutS L that it carries out the mismatch recognition step. This protein has a weak ATPase activity
COPIEHFA_00065 7e-34 S Protein of unknown function (DUF3021)
COPIEHFA_00066 1.2e-61 KT phosphorelay signal transduction system
COPIEHFA_00068 0.0 mutL L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
COPIEHFA_00070 7.8e-103 ruvA 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
COPIEHFA_00071 6.4e-107 tag 3.2.2.20 L 3-methyladenine DNA glycosylase
COPIEHFA_00072 1e-232 cinA 3.5.1.42 S Belongs to the CinA family
COPIEHFA_00073 2.8e-197 recA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
COPIEHFA_00074 2.3e-66 spxA_2 1.20.4.1 P Belongs to the ArsC family
COPIEHFA_00080 2.6e-10
COPIEHFA_00083 1.9e-07
COPIEHFA_00088 0.0 polC 2.7.7.7 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
COPIEHFA_00089 1.2e-235 pepS E COG2309 Leucyl aminopeptidase (aminopeptidase T)
COPIEHFA_00090 5.5e-36 XK27_02060 S Transglycosylase associated protein
COPIEHFA_00091 2.6e-55 badR K DNA-binding transcription factor activity
COPIEHFA_00092 3.5e-97 S reductase
COPIEHFA_00093 6.9e-89 L Integrase core domain protein
COPIEHFA_00094 6.4e-41 L transposition
COPIEHFA_00096 7.9e-76 yocD 3.4.17.13 V carboxypeptidase activity
COPIEHFA_00097 4.6e-91 yocD 3.4.17.13 V proteins, homologs of microcin C7 resistance protein MccF
COPIEHFA_00099 1.3e-137 rpsB J Belongs to the universal ribosomal protein uS2 family
COPIEHFA_00100 1.7e-182 tsf J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
COPIEHFA_00101 1.1e-83 S Putative small multi-drug export protein
COPIEHFA_00102 6.2e-76 ctsR K Belongs to the CtsR family
COPIEHFA_00103 0.0 clpC O Belongs to the ClpA ClpB family
COPIEHFA_00104 7e-127 dacA 3.4.16.4 M Belongs to the peptidase S11 family
COPIEHFA_00105 4.4e-53 dacA 3.4.16.4 M Belongs to the peptidase S11 family
COPIEHFA_00106 2.5e-121 L Transposase
COPIEHFA_00107 1.2e-165 L integrase core domain
COPIEHFA_00108 4.2e-231 dacA 3.4.16.4 M Belongs to the peptidase S11 family
COPIEHFA_00109 0.0 pnp 2.7.7.8 J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
COPIEHFA_00110 6.9e-144 S SseB protein N-terminal domain
COPIEHFA_00111 1.1e-112 cysE 2.3.1.30 E serine acetyltransferase
COPIEHFA_00112 1.7e-259 cysS 6.1.1.16, 6.3.1.13 J Belongs to the class-I aminoacyl-tRNA synthetase family
COPIEHFA_00113 4.2e-68 mrnC J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
COPIEHFA_00116 5.7e-135 trmH 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
COPIEHFA_00117 3.5e-91 yacP S RNA-binding protein containing a PIN domain
COPIEHFA_00118 3.4e-155 degV S DegV family
COPIEHFA_00119 1.8e-31 K helix-turn-helix
COPIEHFA_00120 1.6e-182 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
COPIEHFA_00121 2e-79 rplM J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
COPIEHFA_00122 9.5e-65 rpsI J Belongs to the universal ribosomal protein uS9 family
COPIEHFA_00123 1.5e-35 K sequence-specific DNA binding
COPIEHFA_00125 0.0 S Lantibiotic dehydratase, C terminus
COPIEHFA_00126 7e-231 spaC2 V Lanthionine synthetase C family protein
COPIEHFA_00127 3.3e-183 EGP Major facilitator Superfamily
COPIEHFA_00128 1.6e-91 3.6.4.12 K Divergent AAA domain protein
COPIEHFA_00129 4.1e-223 int L Belongs to the 'phage' integrase family
COPIEHFA_00130 1.7e-12 S Helix-turn-helix domain
COPIEHFA_00132 1.1e-60
COPIEHFA_00133 1.3e-76
COPIEHFA_00135 1.9e-26 isp2 S pathogenesis
COPIEHFA_00136 1.9e-124 tnp L Transposase IS66 family
COPIEHFA_00137 1.3e-41 capA M Bacterial capsule synthesis protein PGA_cap
COPIEHFA_00138 5.6e-109 capA M Bacterial capsule synthesis protein
COPIEHFA_00139 2.5e-58 capA M Bacterial capsule synthesis protein
COPIEHFA_00140 3.6e-39 gcvR T UPF0237 protein
COPIEHFA_00141 1.9e-242 XK27_08635 S UPF0210 protein
COPIEHFA_00142 2.2e-38 ais G alpha-ribazole phosphatase activity
COPIEHFA_00143 1.6e-143 vanY 3.4.17.14 M D-alanyl-D-alanine carboxypeptidase
COPIEHFA_00144 1.3e-102 acmA 3.2.1.17 NU amidase activity
COPIEHFA_00145 5.3e-198 hrcA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
COPIEHFA_00146 1.3e-71 grpE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
COPIEHFA_00147 7.5e-298 dnaK O Heat shock 70 kDa protein
COPIEHFA_00148 9.1e-185 dnaJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
COPIEHFA_00149 7.7e-140 truA 5.4.99.12 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
COPIEHFA_00150 6.2e-137 thiD 2.7.1.35, 2.7.1.49, 2.7.4.7 H phosphomethylpyrimidine kinase
COPIEHFA_00151 1.7e-60 hmpT S membrane
COPIEHFA_00164 0.0 amiA E ABC transporter, substrate-binding protein, family 5
COPIEHFA_00165 2.5e-169 L Transposase
COPIEHFA_00166 9.9e-19 S Domain of unknown function (DUF4649)
COPIEHFA_00167 1.8e-56 amd 3.5.1.47 E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
COPIEHFA_00168 3.2e-233 cfa 2.1.1.317, 2.1.1.79 M cyclopropane-fatty-acyl-phospholipid synthase
COPIEHFA_00169 1e-84
COPIEHFA_00170 1.6e-77 sigH K DNA-templated transcription, initiation
COPIEHFA_00171 9.3e-150 ykuT M mechanosensitive ion channel
COPIEHFA_00172 6.4e-219 tig D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
COPIEHFA_00173 4.8e-73 rpoE K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
COPIEHFA_00174 7.6e-310 pyrG 6.3.4.2 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
COPIEHFA_00175 1.3e-84 XK27_03960 S Protein of unknown function (DUF3013)
COPIEHFA_00176 3.7e-81 mutT3 3.6.1.13, 3.6.1.55 L NUDIX domain
COPIEHFA_00177 3.7e-179 prmA J Ribosomal protein L11 methyltransferase
COPIEHFA_00178 4.4e-135 rsmE 2.1.1.193 J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
COPIEHFA_00179 1.4e-42 F nucleotide catabolic process
COPIEHFA_00180 5.4e-139 cpdB 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
COPIEHFA_00181 7.7e-140 cpdB 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
COPIEHFA_00182 8.6e-51 cpdB 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
COPIEHFA_00183 1.8e-83 nrdI F Belongs to the NrdI family
COPIEHFA_00184 0.0 relA 2.7.6.5 KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
COPIEHFA_00185 2.3e-75 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
COPIEHFA_00186 1.4e-09 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
COPIEHFA_00187 2e-27 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
COPIEHFA_00188 5.6e-59 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
COPIEHFA_00189 1.9e-45 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
COPIEHFA_00190 1.7e-237 ilvA 4.3.1.19 E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
COPIEHFA_00191 3.3e-112 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
COPIEHFA_00192 5.3e-113 fnr5 K Catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
COPIEHFA_00193 9.3e-201 yhjX P Major Facilitator
COPIEHFA_00194 9.2e-43 rpsO J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
COPIEHFA_00195 5e-94 V VanZ like family
COPIEHFA_00197 1e-123 glnQ E abc transporter atp-binding protein
COPIEHFA_00198 5.8e-275 glnP P ABC transporter
COPIEHFA_00199 9.1e-153 uppP 3.6.1.27 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
COPIEHFA_00200 1.3e-134 mecA NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
COPIEHFA_00201 1.8e-183 tagO 2.7.8.33, 2.7.8.35 M transferase
COPIEHFA_00202 9.5e-144 sufC O ABC-type transport system involved in Fe-S cluster assembly, ATPase component
COPIEHFA_00203 4.1e-234 sufD O assembly protein SufD
COPIEHFA_00204 1.3e-237 sufS 2.8.1.7, 4.4.1.16 E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
COPIEHFA_00205 1.1e-74 nifU C SUF system FeS assembly protein, NifU family
COPIEHFA_00206 2.2e-273 sufB O assembly protein SufB
COPIEHFA_00207 2.4e-19 oppA E ABC transporter substrate-binding protein
COPIEHFA_00208 7.9e-140 oppA E ABC transporter substrate-binding protein
COPIEHFA_00209 8.5e-28 oppB P ABC-type dipeptide oligopeptide nickel transport systems, permease components
COPIEHFA_00210 3.6e-42 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
COPIEHFA_00211 1.7e-33 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
COPIEHFA_00212 1.4e-38 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
COPIEHFA_00213 3e-27 oppD P Belongs to the ABC transporter superfamily
COPIEHFA_00214 2.5e-32 oppD P Belongs to the ABC transporter superfamily
COPIEHFA_00215 1.2e-62 oppD P Belongs to the ABC transporter superfamily
COPIEHFA_00216 4.1e-43 oppD P Belongs to the ABC transporter superfamily
COPIEHFA_00217 1.1e-60 oppF P Belongs to the ABC transporter superfamily
COPIEHFA_00218 7.5e-62 oppF P Belongs to the ABC transporter superfamily
COPIEHFA_00219 8.3e-23
COPIEHFA_00220 2.1e-157 hslO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
COPIEHFA_00221 7.4e-183 dus J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
COPIEHFA_00222 7.1e-110 K sequence-specific DNA binding
COPIEHFA_00223 0.0 KLT serine threonine protein kinase
COPIEHFA_00224 1.9e-223 EGP Major facilitator Superfamily
COPIEHFA_00225 9.1e-72 adcR K transcriptional
COPIEHFA_00226 1.1e-135 adcC P ABC transporter, ATP-binding protein
COPIEHFA_00227 9.3e-131 adcB P ABC transporter (Permease
COPIEHFA_00228 4.8e-163 mleP2 S Transporter, auxin efflux carrier (AEC) family protein
COPIEHFA_00229 5.6e-65 ptsG 2.7.1.199, 2.7.1.208 G pts system
COPIEHFA_00230 2.1e-150 ptsG 2.7.1.199, 2.7.1.208, 2.7.1.211 G pts system
COPIEHFA_00231 1.4e-105 ptsG 2.7.1.199, 2.7.1.208, 2.7.1.211 G phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1
COPIEHFA_00232 6.8e-158 rgfB 3.1.3.90 L Endonuclease/Exonuclease/phosphatase family
COPIEHFA_00233 2.8e-257 pgi 5.3.1.9 G Belongs to the GPI family
COPIEHFA_00234 5.5e-127 yeeN K transcriptional regulatory protein
COPIEHFA_00235 9.8e-50 yajC U protein transport
COPIEHFA_00236 1.1e-141 uppS 2.5.1.31 H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
COPIEHFA_00237 2.2e-145 cdsA 2.7.7.41 S Belongs to the CDS family
COPIEHFA_00238 1.4e-231 rseP 3.4.21.107, 3.4.21.116 M zinc metalloprotease
COPIEHFA_00239 0.0 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
COPIEHFA_00240 0.0 WQ51_06230 S ABC transporter substrate binding protein
COPIEHFA_00241 5.2e-142 cmpC S abc transporter atp-binding protein
COPIEHFA_00242 1.3e-42 groS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
COPIEHFA_00243 4.1e-287 groL O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
COPIEHFA_00244 4.4e-37 L Transposase
COPIEHFA_00245 6.4e-18 L transposase activity
COPIEHFA_00246 1.5e-30 L transposition
COPIEHFA_00249 4.7e-43
COPIEHFA_00250 6.8e-56 S TM2 domain
COPIEHFA_00251 1.2e-165 rluA 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
COPIEHFA_00252 0.0 pbp2A 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
COPIEHFA_00253 3.3e-21 rpmG J Belongs to the bacterial ribosomal protein bL33 family
COPIEHFA_00254 5.7e-25 secE U Belongs to the SecE SEC61-gamma family
COPIEHFA_00255 8.4e-96 nusG K Participates in transcription elongation, termination and antitermination
COPIEHFA_00256 4.6e-85 3.1.3.27, 3.1.3.4, 3.1.3.81, 3.6.1.27 I phosphatidate phosphatase activity
COPIEHFA_00257 6e-55 cof Q phosphatase activity
COPIEHFA_00258 1.1e-34 cof Q phosphatase activity
COPIEHFA_00259 4.5e-135 glcR K transcriptional regulator (DeoR family)
COPIEHFA_00260 0.0 leuS 6.1.1.4 J Belongs to the class-I aminoacyl-tRNA synthetase family
COPIEHFA_00261 3.8e-40 K transcriptional
COPIEHFA_00262 6.3e-88 S thiolester hydrolase activity
COPIEHFA_00263 5e-90 S COG1073 Hydrolases of the alpha beta superfamily
COPIEHFA_00264 4.8e-279 pncB 6.3.4.21 H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
COPIEHFA_00265 4.8e-151 nadE 6.3.1.5 H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
COPIEHFA_00266 3.2e-77 yhaI L Membrane
COPIEHFA_00267 1.7e-259 pepC 3.4.22.40 E aminopeptidase
COPIEHFA_00268 0.0 ponA 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
COPIEHFA_00269 2.5e-109 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
COPIEHFA_00270 8.9e-95 ypsA S Belongs to the UPF0398 family
COPIEHFA_00271 2.5e-50 gpsB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
COPIEHFA_00272 2.4e-220 rlmL 2.1.1.173, 2.1.1.264 L Belongs to the methyltransferase superfamily
COPIEHFA_00273 2.6e-298 mapZ D Early cell division protein that marks the future cell division site and supports proper FtsZ ring positioning
COPIEHFA_00274 4.6e-307 snf 2.7.11.1 L Superfamily II DNA RNA helicases, SNF2 family'
COPIEHFA_00275 4.4e-222 snf 2.7.11.1 L Superfamily II DNA RNA helicases, SNF2 family'
COPIEHFA_00276 2.9e-41 snf 2.7.11.1 L Superfamily II DNA RNA helicases, SNF2 family'
COPIEHFA_00277 2.5e-23
COPIEHFA_00278 1.5e-255 mpl 6.3.2.4, 6.3.2.45, 6.3.2.8 M Belongs to the MurCDEF family
COPIEHFA_00279 3.1e-20 XK27_09675 K -acetyltransferase
COPIEHFA_00280 9.3e-46 XK27_09675 K -acetyltransferase
COPIEHFA_00281 0.0 mltG ADL Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
COPIEHFA_00282 1.6e-77 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
COPIEHFA_00283 5.2e-59 L Integrase core domain protein
COPIEHFA_00284 2.9e-165 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
COPIEHFA_00285 7e-46 acyP 3.6.1.7 C Belongs to the acylphosphatase family
COPIEHFA_00286 6.4e-131 spoU 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
COPIEHFA_00287 6.1e-93 XK27_09705 6.1.1.14 S HD superfamily hydrolase
COPIEHFA_00288 8.8e-98 ybhL S Belongs to the BI1 family
COPIEHFA_00291 9.6e-244 lysA 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
COPIEHFA_00292 8.1e-91 K transcriptional regulator
COPIEHFA_00293 7.6e-36 yneF S UPF0154 protein
COPIEHFA_00294 1.3e-148 murI 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
COPIEHFA_00295 3.2e-186 rdgB 3.6.1.66, 5.1.1.3 F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
COPIEHFA_00296 3.5e-99 XK27_09740 S Phosphoesterase
COPIEHFA_00297 5.4e-86 ykuL S CBS domain
COPIEHFA_00298 3.7e-137 xerD L tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site
COPIEHFA_00299 3.1e-122 scpA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
COPIEHFA_00300 3e-99 scpB D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
COPIEHFA_00301 6.1e-140 rluB 5.4.99.19, 5.4.99.21, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
COPIEHFA_00302 1.8e-40 yidD S Could be involved in insertion of integral membrane proteins into the membrane
COPIEHFA_00303 6.3e-58 trkH P Cation transport protein
COPIEHFA_00304 5.2e-182 trkH P Cation transport protein
COPIEHFA_00305 1.5e-247 trkA P Potassium transporter peripheral membrane component
COPIEHFA_00306 7.9e-96 trmL 2.1.1.207 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
COPIEHFA_00307 2.1e-89 ribU U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
COPIEHFA_00308 4.8e-114 bcrC 3.6.1.27 I Membrane-associated phospholipid phosphatase
COPIEHFA_00309 5.6e-161 K sequence-specific DNA binding
COPIEHFA_00310 1.2e-32 V protein secretion by the type I secretion system
COPIEHFA_00311 7.4e-36 V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
COPIEHFA_00312 4.3e-57 V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
COPIEHFA_00313 1.1e-34 V protein secretion by the type I secretion system
COPIEHFA_00314 1.8e-27 comA V protein secretion by the type I secretion system
COPIEHFA_00315 3.4e-68 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
COPIEHFA_00316 3.7e-51 yhaI L Membrane
COPIEHFA_00317 6.7e-36 S Domain of unknown function (DUF4173)
COPIEHFA_00318 9.2e-132 S Domain of unknown function (DUF4173)
COPIEHFA_00319 6.8e-95 ureI S AmiS/UreI family transporter
COPIEHFA_00320 7.6e-46 ureA 3.5.1.5 E Belongs to the urease gamma subunit family
COPIEHFA_00321 7.8e-54 ureB 3.5.1.5 E Belongs to the urease beta subunit family
COPIEHFA_00322 0.0 ureC 3.5.1.5 E Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family
COPIEHFA_00323 6.6e-78 ureE O enzyme active site formation
COPIEHFA_00324 5.3e-130 ureF O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
COPIEHFA_00325 9.5e-112 ureG KO Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
COPIEHFA_00326 7.3e-152 ureD O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
COPIEHFA_00327 1.2e-163 cbiM P PDGLE domain
COPIEHFA_00328 1.1e-136 P cobalt transport protein
COPIEHFA_00329 2e-129 cbiO P ABC transporter
COPIEHFA_00330 4.3e-139 ET amino acid transport
COPIEHFA_00331 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
COPIEHFA_00332 0.0 3.3.1.1, 3.6.1.55, 3.6.1.67 F NUDIX domain
COPIEHFA_00333 3.8e-205 EGP Transmembrane secretion effector
COPIEHFA_00334 6.9e-153 ET amino acid transport
COPIEHFA_00335 3.7e-165 metQ M Belongs to the NlpA lipoprotein family
COPIEHFA_00336 7.1e-86 dapE 3.5.1.18 E COG0624, acetylornithine deacetylase succinyl-diaminopimelate desuccinylase and related deacylases
COPIEHFA_00337 1.4e-62 dapE 3.5.1.18 E succinyl-diaminopimelate desuccinylase activity
COPIEHFA_00338 1e-63 dapE 3.5.1.18 E succinyl-diaminopimelate desuccinylase activity
COPIEHFA_00339 1.5e-189 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
COPIEHFA_00340 3e-98 metI P ABC transporter (Permease
COPIEHFA_00341 1e-210 sstT E Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
COPIEHFA_00342 5.2e-33 salL 2.5.1.63, 2.5.1.94 F Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
COPIEHFA_00343 8.8e-110 salL 2.5.1.63, 2.5.1.94 S S-adenosyl-l-methionine hydroxide adenosyltransferase
COPIEHFA_00344 2.3e-93 S UPF0397 protein
COPIEHFA_00345 0.0 ykoD P abc transporter atp-binding protein
COPIEHFA_00346 1.2e-146 cbiQ P cobalt transport
COPIEHFA_00347 0.0 tkt 2.2.1.1 G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
COPIEHFA_00348 6.9e-11 ulaG S L-ascorbate 6-phosphate lactonase
COPIEHFA_00349 1.4e-121 ktrA P COG0569 K transport systems, NAD-binding component
COPIEHFA_00350 6.1e-244 P COG0168 Trk-type K transport systems, membrane components
COPIEHFA_00351 1.1e-130 rsmG 2.1.1.170 J Ribosomal RNA small subunit methyltransferase G
COPIEHFA_00352 2.4e-90 yceD K metal-binding, possibly nucleic acid-binding protein
COPIEHFA_00353 3e-122 T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
COPIEHFA_00354 1.1e-281 T PhoQ Sensor
COPIEHFA_00355 4.7e-82 nrdR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
COPIEHFA_00356 6.5e-218 dnaB L Replication initiation and membrane attachment
COPIEHFA_00357 4.4e-166 dnaI L Primosomal protein DnaI
COPIEHFA_00358 2.6e-247 der 1.1.1.399, 1.1.1.95 S GTPase that plays an essential role in the late steps of ribosome biogenesis
COPIEHFA_00360 1.2e-34
COPIEHFA_00361 3e-27 L Integrase core domain protein
COPIEHFA_00362 3.4e-50 L transposition
COPIEHFA_00363 5.7e-23 L Transposase
COPIEHFA_00364 1.2e-40 L transposase activity
COPIEHFA_00365 8.8e-223 L Transposase
COPIEHFA_00366 8.6e-232 serS 6.1.1.11 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
COPIEHFA_00367 4.2e-62 manO S protein conserved in bacteria
COPIEHFA_00368 6.2e-168 manN G PTS system mannose fructose sorbose family IID component
COPIEHFA_00369 3.9e-116 manM G pts system
COPIEHFA_00370 2.4e-173 manL 2.7.1.191 G pts system
COPIEHFA_00371 4.4e-140 XK27_00940 1.2.1.70, 3.5.1.9 S Metal-dependent hydrolase
COPIEHFA_00372 1e-153 yitU 3.1.3.104 S hydrolases of the HAD superfamily
COPIEHFA_00373 6.1e-45 pbuO S permease
COPIEHFA_00374 7.1e-190 pbuO S permease
COPIEHFA_00375 1.4e-77 ydiB 2.7.1.221, 5.1.1.1 M ATPase or kinase
COPIEHFA_00376 3.2e-92 XK27_05885 2.3.1.82 M Acetyltransferase GNAT Family
COPIEHFA_00377 2.8e-219 brpA K Transcriptional
COPIEHFA_00378 3.9e-81 rimP S Required for maturation of 30S ribosomal subunits
COPIEHFA_00379 3.1e-212 nusA K Participates in both transcription termination and antitermination
COPIEHFA_00380 1e-47 ylxR K Nucleic-acid-binding protein implicated in transcription termination
COPIEHFA_00381 1.4e-41 ylxQ J ribosomal protein
COPIEHFA_00382 0.0 infB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
COPIEHFA_00383 1.7e-57 rbfA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
COPIEHFA_00384 2e-22 yvdD 3.2.2.10 S Belongs to the LOG family
COPIEHFA_00385 1.5e-25 yvdD 3.2.2.10 S cytokinin biosynthetic process
COPIEHFA_00386 8.9e-81 femA 2.3.2.10, 2.3.2.16, 2.3.2.17, 2.3.2.18 V protein involved in methicillin resistance
COPIEHFA_00387 2.1e-140 femA 2.3.2.10, 2.3.2.16, 2.3.2.17, 2.3.2.18 V protein involved in methicillin resistance
COPIEHFA_00388 1.4e-275 murE 6.3.2.13, 6.3.2.7 M to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
COPIEHFA_00389 3.8e-282 ytgP S Membrane protein involved in the export of O-antigen and teichoic acid
COPIEHFA_00390 1.1e-96 pacL 3.6.3.8, 3.6.3.9 P cation transport ATPase
COPIEHFA_00391 1.4e-201 metB 2.5.1.48, 4.4.1.8 E cystathionine
COPIEHFA_00392 7.3e-222 malY 4.4.1.8 E COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
COPIEHFA_00394 3.1e-09 sacB 2.4.1.10, 2.4.1.9, 3.2.1.26 GH32,GH68 G Belongs to the glycosyl hydrolase 68 family
COPIEHFA_00395 4.4e-112 upp 2.4.2.9 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
COPIEHFA_00396 2.9e-105 clpP 3.4.21.92 OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
COPIEHFA_00397 1.5e-74 ylbF S Belongs to the UPF0342 family
COPIEHFA_00398 7.1e-46 ylbG S UPF0298 protein
COPIEHFA_00399 1.3e-210 livJ E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component
COPIEHFA_00400 1.9e-145 livH E Belongs to the binding-protein-dependent transport system permease family
COPIEHFA_00401 1.4e-138 livM E Belongs to the binding-protein-dependent transport system permease family
COPIEHFA_00402 9.6e-138 livG E COG0411 ABC-type branched-chain amino acid transport systems, ATPase component
COPIEHFA_00403 4.8e-123 livF E COG0410 ABC-type branched-chain amino acid transport systems, ATPase component
COPIEHFA_00404 6.8e-69 acuB S IMP dehydrogenase activity
COPIEHFA_00405 8.9e-41 acuB S IMP dehydrogenase activity
COPIEHFA_00406 3.7e-168 cysK 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
COPIEHFA_00407 1.1e-110 yvyE 3.4.13.9 S YigZ family
COPIEHFA_00408 4.5e-252 comFA L Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
COPIEHFA_00409 1.7e-122 comFC S Competence protein
COPIEHFA_00410 2.1e-94 hpf J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
COPIEHFA_00418 2.1e-166 ppaC 3.6.1.1 C inorganic pyrophosphatase
COPIEHFA_00419 6.4e-108 S Domain of unknown function (DUF1803)
COPIEHFA_00420 7.8e-102 ygaC J Belongs to the UPF0374 family
COPIEHFA_00421 3.6e-132 recX 2.4.1.337 GT4 S Regulatory protein RecX
COPIEHFA_00422 1.4e-259 rumA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
COPIEHFA_00423 8e-193 asnA 6.3.1.1 E aspartate--ammonia ligase
COPIEHFA_00424 2.4e-256 lysC 2.7.2.4 E Belongs to the aspartokinase family
COPIEHFA_00425 6.8e-75 S Haloacid dehalogenase-like hydrolase
COPIEHFA_00426 2.4e-139 phaB 5.3.3.14, 5.3.3.18 I Belongs to the enoyl-CoA hydratase isomerase family
COPIEHFA_00427 4e-72 marR K Transcriptional regulator, MarR family
COPIEHFA_00428 2.3e-173 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
COPIEHFA_00429 3.3e-30 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
COPIEHFA_00430 5.8e-172 fabK 1.3.1.9 S 2-Nitropropane dioxygenase
COPIEHFA_00431 5.5e-164 fabD 2.3.1.39 I Malonyl CoA-acyl carrier protein transacylase
COPIEHFA_00432 1.6e-126 IQ reductase
COPIEHFA_00433 1.5e-233 fabF 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
COPIEHFA_00434 7e-57 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
COPIEHFA_00435 4.3e-71 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
COPIEHFA_00436 1.4e-256 accC 6.3.4.14, 6.4.1.2 I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
COPIEHFA_00437 1.1e-158 accD 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
COPIEHFA_00438 8.8e-139 accA 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
COPIEHFA_00439 4.7e-90 luxS 4.4.1.21 H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
COPIEHFA_00440 1.1e-127 tnp L Transposase
COPIEHFA_00441 1.8e-115 gadB 4.1.1.15 E Belongs to the group II decarboxylase family
COPIEHFA_00442 3.1e-202 rny D Endoribonuclease that initiates mRNA decay
COPIEHFA_00443 8.9e-84 L Transposase
COPIEHFA_00444 2.1e-113 fruR K transcriptional
COPIEHFA_00445 1.6e-163 pfkB 2.7.1.11, 2.7.1.56 H Belongs to the carbohydrate kinase PfkB family. LacC subfamily
COPIEHFA_00446 4.8e-115 fruA 2.7.1.202 GT PTS system, Lactose/Cellobiose specific IIB subunit
COPIEHFA_00447 6.2e-139 fruA 2.7.1.202 G phosphotransferase system
COPIEHFA_00448 1.6e-36 fruA 2.7.1.202 G phosphotransferase system
COPIEHFA_00449 2.7e-260 gor 1.8.1.7 C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
COPIEHFA_00450 3.1e-242 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
COPIEHFA_00452 1.8e-212 iscS2 2.8.1.7 E Cysteine sulfinate desulfinase cysteine desulfurase and related enzymes
COPIEHFA_00453 6.5e-229 thiI 2.8.1.4 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
COPIEHFA_00454 8.4e-295 gtf1 2.4.1.52 GT4 M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
COPIEHFA_00455 9.4e-258 gtf2 M A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1
COPIEHFA_00456 3.3e-39 2.3.1.128 K acetyltransferase
COPIEHFA_00457 2.6e-27 2.3.1.128 K acetyltransferase
COPIEHFA_00458 1.7e-48 rplU J This protein binds to 23S rRNA in the presence of protein L20
COPIEHFA_00459 1.5e-46 rpmA J Belongs to the bacterial ribosomal protein bL27 family
COPIEHFA_00460 1e-122 ydaF_2 J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
COPIEHFA_00461 2.3e-60 WQ51_03320 S cog cog4835
COPIEHFA_00462 1.9e-60 XK27_08360 S EDD domain protein, DegV family
COPIEHFA_00463 3.6e-74 XK27_08360 S EDD domain protein, DegV family
COPIEHFA_00464 5.1e-139 dapB 1.17.1.8 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
COPIEHFA_00465 1.6e-224 cca 2.7.7.19, 2.7.7.72 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
COPIEHFA_00466 0.0 yfmR S abc transporter atp-binding protein
COPIEHFA_00467 1.6e-24 U response to pH
COPIEHFA_00468 1.1e-141 3.6.1.13, 3.6.1.55 F AdP-ribose pyrophosphatase
COPIEHFA_00469 6.5e-212 nadD 2.7.1.22, 2.7.7.1, 2.7.7.18, 3.6.1.55 H adenylyltransferase
COPIEHFA_00470 1.8e-256 gdhA 1.4.1.4 E Belongs to the Glu Leu Phe Val dehydrogenases family
COPIEHFA_00471 1e-69 def_1 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins
COPIEHFA_00472 1.9e-77 K DNA-binding transcription factor activity
COPIEHFA_00473 2.3e-274 lmrA1 V abc transporter atp-binding protein
COPIEHFA_00474 0.0 lmrA2 V abc transporter atp-binding protein
COPIEHFA_00475 2.2e-18 K Acetyltransferase (GNAT) family
COPIEHFA_00476 1.1e-19 sptS 2.7.13.3 T Histidine kinase
COPIEHFA_00477 1.6e-118 sptS 2.7.13.3 T Histidine kinase
COPIEHFA_00478 4.9e-131 pyrH 2.7.4.22 F Catalyzes the reversible phosphorylation of UMP to UDP
COPIEHFA_00479 1.3e-91 frr J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
COPIEHFA_00480 1.2e-68 cvfB S Protein conserved in bacteria
COPIEHFA_00481 1.9e-83 cvfB S Protein conserved in bacteria
COPIEHFA_00482 7.4e-35 yozE S Belongs to the UPF0346 family
COPIEHFA_00483 1.4e-118 usp 3.5.1.104, 3.5.1.28 CBM50 S pathogenesis
COPIEHFA_00485 2.6e-60 rlpA M LysM domain protein
COPIEHFA_00486 1.5e-189 phoH T phosphate starvation-inducible protein PhoH
COPIEHFA_00489 0.0 metG 6.1.1.10, 6.1.1.20 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
COPIEHFA_00490 1.8e-164 K transcriptional regulator (lysR family)
COPIEHFA_00491 1.4e-186 coiA 3.6.4.12 S Competence protein
COPIEHFA_00492 0.0 pepF E oligoendopeptidase F
COPIEHFA_00493 5.4e-127 yrrM 2.1.1.104 S O-Methyltransferase
COPIEHFA_00494 5.1e-167 prsA 3.1.3.16, 5.2.1.8 O peptidyl-prolyl cis-trans isomerase activity
COPIEHFA_00495 0.0 alaS 6.1.1.7 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
COPIEHFA_00496 7.9e-24 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
COPIEHFA_00497 2.9e-92 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
COPIEHFA_00498 5.4e-65 3.4.17.14, 3.5.1.28 NU amidase activity
COPIEHFA_00499 1.8e-30 3.4.17.14, 3.5.1.28 NU amidase activity
COPIEHFA_00500 7.1e-89 3.4.17.14, 3.5.1.28 NU amidase activity
COPIEHFA_00501 1.5e-146 cnhA 3.5.1.3 S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
COPIEHFA_00502 1.2e-227 mtnE 2.6.1.83 E mutations do not affect methionine salvage in vivo however
COPIEHFA_00503 1.5e-191 argC 1.2.1.38 E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
COPIEHFA_00504 1.5e-222 argJ 2.3.1.1, 2.3.1.35, 2.7.2.8 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
COPIEHFA_00505 3.5e-129 argB 2.7.2.8 E Belongs to the acetylglutamate kinase family. ArgB subfamily
COPIEHFA_00506 2.1e-141 argD 2.6.1.11, 2.6.1.17 E acetylornithine aminotransferase
COPIEHFA_00507 3e-48 argD 2.6.1.11, 2.6.1.17 E acetylornithine aminotransferase
COPIEHFA_00508 3.2e-129 yxkH G deacetylase
COPIEHFA_00509 4e-237 hom 1.1.1.3, 2.7.2.4 E homoserine dehydrogenase
COPIEHFA_00510 1.1e-153 thrB 2.7.1.39 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
COPIEHFA_00511 5.5e-153 rarD S Transporter
COPIEHFA_00512 2.2e-15 T peptidase
COPIEHFA_00513 8.9e-14 coiA 3.6.4.12 S Competence protein
COPIEHFA_00514 4.1e-112 S COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
COPIEHFA_00515 1.9e-46 2.3.1.128, 5.2.1.8 J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
COPIEHFA_00516 0.0 valS 6.1.1.9 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
COPIEHFA_00517 3.2e-16 atpE C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
COPIEHFA_00518 3.1e-122 atpB C it plays a direct role in the translocation of protons across the membrane
COPIEHFA_00519 3.3e-78 atpF C ATP synthase F(0) sector subunit b
COPIEHFA_00520 3.5e-86 atpH C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
COPIEHFA_00521 3.8e-279 atpA 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
COPIEHFA_00522 2.5e-158 atpG C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
COPIEHFA_00523 2.7e-263 atpD 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
COPIEHFA_00524 5.2e-67 atpC C Produces ATP from ADP in the presence of a proton gradient across the membrane
COPIEHFA_00525 2.8e-230 ftsW D Belongs to the SEDS family
COPIEHFA_00526 9.5e-225 tuf J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
COPIEHFA_00527 1.4e-136 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
COPIEHFA_00528 1.7e-111 tmk 2.7.4.9 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
COPIEHFA_00529 6.4e-162 holB 2.7.7.7 L dna polymerase iii
COPIEHFA_00530 1.2e-135 yaaT S stage 0 sporulation protein
COPIEHFA_00531 9.5e-55 yabA L Involved in initiation control of chromosome replication
COPIEHFA_00532 2.7e-160 rsmI 2.1.1.198 H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
COPIEHFA_00533 2.6e-233 amt P Ammonium Transporter
COPIEHFA_00534 1.1e-53 glnB K Belongs to the P(II) protein family
COPIEHFA_00535 4.9e-106 mur1 NU mannosyl-glycoprotein
COPIEHFA_00536 5.8e-149 XK27_04800 S Sucrose-6F-phosphate phosphohydrolase
COPIEHFA_00537 1.2e-92 nptA P COG1283 Na phosphate symporter
COPIEHFA_00538 8e-221 nagA 3.5.1.25 G Belongs to the metallo-dependent hydrolases superfamily. NagA family
COPIEHFA_00539 4.9e-51
COPIEHFA_00540 2.2e-25
COPIEHFA_00541 3.9e-60
COPIEHFA_00542 6.1e-63 S membrane
COPIEHFA_00543 4.8e-176 glyQ 6.1.1.14 J glycyl-tRNA synthetase alpha subunit
COPIEHFA_00544 0.0 glyS 6.1.1.14 J Glycyl-tRNA synthetase beta subunit
COPIEHFA_00545 4.5e-39 ynzC S UPF0291 protein
COPIEHFA_00546 1.8e-254 cycA E permease
COPIEHFA_00547 1.1e-09 uvrX 2.7.7.7 L ImpB mucB samB family
COPIEHFA_00548 1.5e-25 2.7.1.208, 2.7.1.211 G protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
COPIEHFA_00549 5.8e-71 pts33BCA G pts system
COPIEHFA_00550 9e-96 pts33BCA G pts system
COPIEHFA_00551 1.5e-77 2.7.1.199, 2.7.1.211 G PTS glucose transporter subunit IIA
COPIEHFA_00552 3.2e-141 ppiA 5.2.1.8 O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
COPIEHFA_00553 1.2e-165 L integrase core domain
COPIEHFA_00554 5.1e-122 L Transposase
COPIEHFA_00559 3.1e-167 fhuR K transcriptional regulator (lysR family)
COPIEHFA_00560 1.5e-77 lspA 3.4.23.36 MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins
COPIEHFA_00561 4.5e-163 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
COPIEHFA_00562 3.7e-88 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
COPIEHFA_00563 6.4e-227 pyrP F uracil Permease
COPIEHFA_00564 1e-173 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
COPIEHFA_00565 1.6e-210 carA 6.3.5.5 F carbamoyl-phosphate synthetase glutamine chain
COPIEHFA_00566 0.0 carB 6.3.5.5 F carbamoyl-phosphate synthetase ammonia chain
COPIEHFA_00567 2.2e-134 2.1.1.223 S Putative SAM-dependent methyltransferase
COPIEHFA_00568 4e-37 acrA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
COPIEHFA_00569 1.2e-50 V efflux transmembrane transporter activity
COPIEHFA_00570 3.6e-32 V efflux transmembrane transporter activity
COPIEHFA_00571 7e-27 ytrF V efflux transmembrane transporter activity
COPIEHFA_00572 5.6e-78 rplJ J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
COPIEHFA_00573 3.9e-52 rplL J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
COPIEHFA_00575 0.0 mdlB V abc transporter atp-binding protein
COPIEHFA_00576 0.0 lmrA V abc transporter atp-binding protein
COPIEHFA_00577 6e-199 queA 2.4.99.17 J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
COPIEHFA_00578 2.6e-121 nagB 3.1.1.31, 3.5.99.6 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
COPIEHFA_00579 3.3e-215 2.7.13.3 T signal transduction protein with a C-terminal ATPase domain
COPIEHFA_00580 2.5e-132 rr02 KT response regulator
COPIEHFA_00581 1.1e-217 2.7.7.73, 2.7.7.80 H Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
COPIEHFA_00582 4.8e-168 V ABC transporter
COPIEHFA_00583 5.4e-122 sagI S ABC-2 type transporter
COPIEHFA_00584 1e-195 yceA S Belongs to the UPF0176 family
COPIEHFA_00585 4.3e-22
COPIEHFA_00586 1.2e-143 deoD_1 2.4.2.3 F Phosphorylase superfamily
COPIEHFA_00587 9.6e-113 S VIT family
COPIEHFA_00588 7.4e-132 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
COPIEHFA_00589 1.2e-219 hipO 3.5.1.47 E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
COPIEHFA_00590 3.4e-17 ald 1.4.1.1 E alanine dehydrogenase activity
COPIEHFA_00591 1.7e-46 ald 1.4.1.1 C Belongs to the AlaDH PNT family
COPIEHFA_00592 3e-248 merA 1.16.1.1 C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
COPIEHFA_00593 2.4e-07 ytjP 3.5.1.18 E Dipeptidase
COPIEHFA_00594 3.2e-97 ET Bacterial extracellular solute-binding proteins, family 3
COPIEHFA_00595 1.9e-59 K Acetyltransferase (GNAT) domain
COPIEHFA_00597 7.3e-151 1.8.5.7 O Glutathione S-transferase
COPIEHFA_00598 1.2e-170 1.8.5.7 O Glutathione S-transferase, C-terminal domain
COPIEHFA_00599 7.4e-142 mvk 1.1.1.88, 2.3.3.10, 2.7.1.36 I mevalonate kinase
COPIEHFA_00600 6e-174 mvaD 4.1.1.33 I diphosphomevalonate decarboxylase
COPIEHFA_00601 3.3e-178 mvaK2 2.7.1.36, 2.7.1.43, 2.7.4.2 I GHMP kinases N terminal domain
COPIEHFA_00602 4.4e-191 fni 1.1.1.88, 5.3.3.2 C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
COPIEHFA_00603 1.5e-253 glmU 2.3.1.157, 2.7.7.23 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
COPIEHFA_00604 1e-96 nudF 3.6.1.13 L AdP-ribose pyrophosphatase
COPIEHFA_00605 2.5e-21
COPIEHFA_00606 3.8e-117 mtnN 3.2.2.9 E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
COPIEHFA_00608 3.5e-07 U protein secretion
COPIEHFA_00609 2.1e-50 U protein secretion
COPIEHFA_00610 1.1e-11 U protein secretion
COPIEHFA_00611 1.4e-192 dgs 2.4.1.208 GT4 M Glycosyltransferase, group 1 family protein
COPIEHFA_00612 1.8e-248 mgs 2.4.1.337 GT4 M Glycosyltransferase, group 1 family protein
COPIEHFA_00613 4.9e-21 XK27_13030
COPIEHFA_00614 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
COPIEHFA_00615 8.9e-57 S hydrolase activity, acting on ester bonds
COPIEHFA_00616 9.4e-71 S hydrolases or acyltransferases (alpha beta hydrolase superfamily)
COPIEHFA_00617 2.3e-164 S Protein of unknown function (DUF3114)
COPIEHFA_00618 3.6e-22 S Protein of unknown function (DUF3114)
COPIEHFA_00619 4.7e-120 yqfA K protein, Hemolysin III
COPIEHFA_00620 1.5e-231 mvaA 1.1.1.34, 1.1.1.88, 2.3.1.9 C Belongs to the HMG-CoA reductase family
COPIEHFA_00621 1.7e-218 mvaS 2.3.3.10 I synthase
COPIEHFA_00622 2.2e-167 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
COPIEHFA_00623 1.3e-90 folA 1.5.1.3, 1.5.1.47, 2.1.1.45, 3.5.4.12 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
COPIEHFA_00624 9.7e-22
COPIEHFA_00625 5.7e-225 clpX O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
COPIEHFA_00626 3e-110 engB D Necessary for normal cell division and for the maintenance of normal septation
COPIEHFA_00627 1.3e-249 mmuP E amino acid
COPIEHFA_00628 2.2e-176 mmuM 1.5.1.20, 2.1.1.10 H Homocysteine
COPIEHFA_00629 1.4e-29 S Domain of unknown function (DUF1912)
COPIEHFA_00630 8.3e-08 L Helix-hairpin-helix DNA-binding motif class 1
COPIEHFA_00631 7.1e-102 plsY 2.3.1.15, 3.5.1.104 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
COPIEHFA_00632 0.0 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
COPIEHFA_00633 0.0 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
COPIEHFA_00634 2.4e-200 ilvE 2.6.1.42 E Aminotransferase
COPIEHFA_00635 4.8e-16 S Protein of unknown function (DUF2969)
COPIEHFA_00638 8.4e-205 rpsA 1.17.7.4 J ribosomal protein S1
COPIEHFA_00640 8.8e-223 L Transposase
COPIEHFA_00642 3.5e-24 S Domain of Unknown Function with PDB structure (DUF3862)
COPIEHFA_00643 5.3e-60 S Domain of Unknown Function with PDB structure (DUF3862)
COPIEHFA_00644 3.4e-233 murN 2.3.2.10, 2.3.2.16 V FemAB family
COPIEHFA_00645 2.4e-66 S oxidoreductase
COPIEHFA_00646 7.4e-49 XK27_09445 S Domain of unknown function (DUF1827)
COPIEHFA_00647 1.8e-86 mutT 3.5.4.33, 3.6.1.13, 3.6.1.55 L Belongs to the Nudix hydrolase family
COPIEHFA_00648 0.0 clpE O Belongs to the ClpA ClpB family
COPIEHFA_00649 1.6e-182 argF 2.1.3.3 E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
COPIEHFA_00650 1.3e-34 ykuJ S protein conserved in bacteria
COPIEHFA_00651 7.5e-118 WQ51_01820 P Binding-protein-dependent transport system inner membrane component
COPIEHFA_00652 9.3e-130 glnQ 3.6.3.21 E abc transporter atp-binding protein
COPIEHFA_00653 9.1e-78 feoA P FeoA domain protein
COPIEHFA_00654 2.2e-182 feoB P transporter of a GTP-driven Fe(2 ) uptake system
COPIEHFA_00655 3.8e-193 feoB P transporter of a GTP-driven Fe(2 ) uptake system
COPIEHFA_00656 6.6e-08
COPIEHFA_00657 3.4e-35 yugF I carboxylic ester hydrolase activity
COPIEHFA_00658 5.8e-23 I Alpha/beta hydrolase family
COPIEHFA_00659 2.7e-157 folD 1.5.1.5, 3.5.4.9 F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
COPIEHFA_00660 1.7e-148 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
COPIEHFA_00661 0.0 pbp2b 3.4.16.4 M penicillin-binding protein
COPIEHFA_00662 2.9e-105 recR L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
COPIEHFA_00663 4.9e-63 licT K transcriptional antiterminator
COPIEHFA_00664 1.7e-51 licT K transcriptional antiterminator
COPIEHFA_00665 5.9e-88 ybeY 2.6.99.2, 3.5.4.5 S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
COPIEHFA_00666 3.7e-64 dgkA 2.7.1.107, 2.7.1.66 M Diacylglycerol kinase
COPIEHFA_00667 2.9e-165 era M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
COPIEHFA_00668 9.3e-155 fpg 3.2.2.23, 4.2.99.18 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
COPIEHFA_00669 1.1e-104 coaE 2.7.1.24, 3.2.2.23, 4.2.99.18 GH23 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
COPIEHFA_00670 2.1e-219 mdtG EGP Major facilitator Superfamily
COPIEHFA_00671 2e-33 secG U Preprotein translocase subunit SecG
COPIEHFA_00672 0.0 rnr J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
COPIEHFA_00673 1.1e-80 smpB O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
COPIEHFA_00674 3.7e-276 ppiB 5.2.1.8 G PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
COPIEHFA_00675 2.3e-50 yugI 5.3.1.9 J RNA binding protein, contains ribosomal protein S1 domain
COPIEHFA_00676 4.2e-211 pepQ 3.4.13.9 E Belongs to the peptidase M24B family
COPIEHFA_00677 3.4e-183 ccpA K Catabolite control protein A
COPIEHFA_00678 4e-27 yyaQ S YjbR
COPIEHFA_00679 2.9e-142 yyaQ S YjbR
COPIEHFA_00680 1.4e-206 glxK 2.7.1.165 G Belongs to the glycerate kinase type-1 family
COPIEHFA_00681 4.5e-74 yueI S Protein of unknown function (DUF1694)
COPIEHFA_00682 2.8e-246 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
COPIEHFA_00684 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
COPIEHFA_00685 7.6e-219 ywbD 2.1.1.191 J Methyltransferase
COPIEHFA_00686 3.3e-121 aroD 1.1.1.25, 4.2.1.10 E Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
COPIEHFA_00687 1.7e-162 aroE 1.1.1.25 E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
COPIEHFA_00688 7.7e-202 aroB 2.7.1.71, 4.2.3.4 E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
COPIEHFA_00689 4.5e-219 aroC 4.2.3.5 E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
COPIEHFA_00690 2.2e-207 tyrA 1.3.1.12, 1.3.1.43 E prephenate dehydrogenase
COPIEHFA_00691 3.2e-53 yheA S Belongs to the UPF0342 family
COPIEHFA_00692 1.2e-116 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
COPIEHFA_00693 1.4e-34 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
COPIEHFA_00694 2.6e-236 aroA 1.3.1.12, 1.3.1.43, 2.5.1.19 E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
COPIEHFA_00695 1.7e-87 aroK 1.1.1.25, 2.7.1.71, 4.2.1.10, 4.2.3.4 F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
COPIEHFA_00696 6.7e-153 pheA 4.2.1.51 E Prephenate dehydratase
COPIEHFA_00697 6.4e-252 msrR K Transcriptional regulator
COPIEHFA_00698 2.2e-149 ydiA P C4-dicarboxylate transporter malic acid transport protein
COPIEHFA_00699 2.4e-203 I acyl-CoA dehydrogenase
COPIEHFA_00700 4.5e-97 mip S hydroperoxide reductase activity
COPIEHFA_00701 1.7e-257 rumA 2.1.1.190 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
COPIEHFA_00702 8.9e-20
COPIEHFA_00703 7e-46
COPIEHFA_00704 2.5e-28 estA E GDSL-like Lipase/Acylhydrolase
COPIEHFA_00705 2.4e-94
COPIEHFA_00706 1.6e-249 L Transposase
COPIEHFA_00707 0.0 cas9 L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
COPIEHFA_00708 3.2e-172 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
COPIEHFA_00709 3.1e-53 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
COPIEHFA_00710 5.7e-189 S CRISPR-associated protein Csn2 subfamily St
COPIEHFA_00711 2.3e-145 ycgQ S TIGR03943 family
COPIEHFA_00712 8.4e-157 XK27_03015 S permease
COPIEHFA_00714 0.0 yhgF K Transcriptional accessory protein
COPIEHFA_00715 9.9e-42 pspC KT PspC domain
COPIEHFA_00716 5.8e-169 hprK F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
COPIEHFA_00717 4e-147 lgt 2.1.1.199 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
COPIEHFA_00719 5.5e-69 ytxH S General stress protein
COPIEHFA_00721 2e-177 yegQ O Peptidase U32
COPIEHFA_00722 3.4e-252 yegQ O Peptidase U32
COPIEHFA_00723 8.1e-46 S CHY zinc finger
COPIEHFA_00724 3.5e-86 bioY S biotin synthase
COPIEHFA_00726 1.1e-33 XK27_12190 S protein conserved in bacteria
COPIEHFA_00727 5.1e-235 mntH P H( )-stimulated, divalent metal cation uptake system
COPIEHFA_00728 2.1e-11
COPIEHFA_00729 1.2e-67 nudG 3.6.1.55, 3.6.1.65 L Belongs to the Nudix hydrolase family
COPIEHFA_00730 0.0 L helicase
COPIEHFA_00731 2.2e-287 lysS 6.1.1.6 J Belongs to the class-II aminoacyl-tRNA synthetase family
COPIEHFA_00732 6.4e-158 M LysM domain
COPIEHFA_00733 7.6e-16
COPIEHFA_00734 8.9e-175 S hydrolase
COPIEHFA_00735 4.8e-100 pgm6 5.4.2.11, 5.4.2.12 G Phosphoglycerate mutase
COPIEHFA_00736 4.5e-35 ybaK S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
COPIEHFA_00737 1.5e-19 ybaK S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
COPIEHFA_00738 2e-145 XK27_00880 3.5.1.28 M Glycosyl hydrolase, family 25
COPIEHFA_00739 2.7e-27 P Hemerythrin HHE cation binding domain protein
COPIEHFA_00740 2.3e-113 1.14.14.5 C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
COPIEHFA_00741 7.2e-23 MA20_36090 S Protein of unknown function (DUF2974)
COPIEHFA_00742 2.1e-23 MA20_36090 S Protein of unknown function (DUF2974)
COPIEHFA_00743 5e-126 sdh 1.1.1.276, 1.1.1.313, 1.1.1.381 S Belongs to the short-chain dehydrogenases reductases (SDR) family
COPIEHFA_00744 0.0 hsdR 3.1.21.3 L Subunit R is required for both nuclease and ATPase activities, but not for modification
COPIEHFA_00745 1.6e-164 S SIR2-like domain
COPIEHFA_00746 0.0 S Domain of unknown function DUF87
COPIEHFA_00747 3.8e-125 hsdS 3.1.21.3 V type I restriction modification DNA specificity domain protein
COPIEHFA_00748 1e-42 K Helix-turn-helix domain
COPIEHFA_00749 2.8e-304 hsdM 2.1.1.72 V type I restriction-modification system
COPIEHFA_00751 5.5e-125 spd F DNA RNA non-specific endonuclease
COPIEHFA_00752 1.5e-92 lemA S LemA family
COPIEHFA_00753 5.4e-132 htpX O Belongs to the peptidase M48B family
COPIEHFA_00754 1.8e-73 S Psort location CytoplasmicMembrane, score
COPIEHFA_00755 6.2e-56 S Domain of unknown function (DUF4430)
COPIEHFA_00756 0.0 ppc 4.1.1.31 H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
COPIEHFA_00757 2.4e-184 holA 2.7.7.7 L DNA polymerase III delta subunit
COPIEHFA_00758 8.5e-113 sodA 1.15.1.1 C radicals which are normally produced within the cells and which are toxic to biological systems
COPIEHFA_00759 2.2e-185 3.5.2.6 V D-alanyl-D-alanine carboxypeptidase
COPIEHFA_00760 4.4e-115 pilD 3.4.23.43 NOU Bacterial Peptidase A24 N-terminal domain
COPIEHFA_00761 3.5e-91 dps P Belongs to the Dps family
COPIEHFA_00762 1.4e-71 perR P Belongs to the Fur family
COPIEHFA_00763 8.4e-28 yqgQ S protein conserved in bacteria
COPIEHFA_00764 2.2e-179 glk 2.7.1.2 G Glucokinase
COPIEHFA_00765 0.0 typA T GTP-binding protein TypA
COPIEHFA_00767 1.6e-252 murD 6.3.2.9 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
COPIEHFA_00768 3.9e-201 murG 2.4.1.227 GT28 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
COPIEHFA_00769 3.2e-166 divIB D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
COPIEHFA_00770 2.3e-246 ftsA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
COPIEHFA_00771 7.8e-236 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
COPIEHFA_00772 3.3e-121 ylmE S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
COPIEHFA_00773 4.1e-93 sepF D cell septum assembly
COPIEHFA_00774 5.7e-34 yggT D integral membrane protein
COPIEHFA_00775 6.1e-143 ylmH T S4 RNA-binding domain
COPIEHFA_00776 1.8e-135 divIVA D Cell division protein DivIVA
COPIEHFA_00777 0.0 ileS 6.1.1.5 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
COPIEHFA_00778 5.5e-30
COPIEHFA_00779 8.2e-10
COPIEHFA_00780 3.2e-231 mntH P Mn2 and Fe2 transporters of the NRAMP family
COPIEHFA_00781 2e-45 rpmE2 J 50S ribosomal protein L31
COPIEHFA_00782 9.8e-177 apbE 2.7.1.180 H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
COPIEHFA_00783 1e-184 nrnA 3.1.13.3, 3.1.3.7 S domain protein
COPIEHFA_00784 8.9e-155 gst O Glutathione S-transferase
COPIEHFA_00785 4.6e-188 add 3.5.4.4 F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
COPIEHFA_00786 4.5e-111 tdk 2.7.1.21 F thymidine kinase
COPIEHFA_00787 3e-193 prfA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
COPIEHFA_00788 1.2e-154 prmB 2.1.1.297, 2.1.1.298 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
COPIEHFA_00789 9.7e-109 ywlC 2.7.7.87, 3.1.3.48 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
COPIEHFA_00790 1.8e-234 glyA 2.1.2.1 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
COPIEHFA_00791 1.2e-177 ndpA S 37-kD nucleoid-associated bacterial protein
COPIEHFA_00792 6.6e-105 pvaA M lytic transglycosylase activity
COPIEHFA_00793 0.0 yfiB1 V abc transporter atp-binding protein
COPIEHFA_00794 0.0 XK27_10035 V abc transporter atp-binding protein
COPIEHFA_00795 1.7e-09 S D-Ala-teichoic acid biosynthesis protein
COPIEHFA_00796 1.4e-297 dltA 6.1.1.13 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
COPIEHFA_00797 3.9e-237 dltB M Membrane protein involved in D-alanine export
COPIEHFA_00798 1.7e-35 dltC 6.1.1.13 IQ Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
COPIEHFA_00799 4.7e-230 dltD M Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
COPIEHFA_00800 9.3e-239 L Transposase
COPIEHFA_00801 9.8e-32 L Integrase core domain protein
COPIEHFA_00802 9.6e-32 L transposition
COPIEHFA_00803 6.5e-54 L transposition
COPIEHFA_00804 7.7e-19 L transposase activity
COPIEHFA_00805 0.0 3.6.3.8 P cation transport ATPase
COPIEHFA_00806 0.0 pabB 2.6.1.85, 4.1.3.27, 4.1.3.38 EH component I
COPIEHFA_00808 0.0 metE 2.1.1.14 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
COPIEHFA_00809 3.6e-165 metF 1.5.1.20 C reductase
COPIEHFA_00810 0.0 pgm 5.4.2.2, 5.4.2.8 G Phosphoglucomutase
COPIEHFA_00811 1.2e-92 panT S ECF transporter, substrate-specific component
COPIEHFA_00812 4.8e-94 coaBC 4.1.1.36, 6.3.2.5 H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
COPIEHFA_00813 6.2e-120 coaB 4.1.1.36, 6.3.2.5 H Phosphopantothenate-cysteine ligase
COPIEHFA_00814 0.0 fhs 6.3.4.3 F Belongs to the formate--tetrahydrofolate ligase family
COPIEHFA_00815 6.4e-66 T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
COPIEHFA_00816 4.3e-41 T PhoQ Sensor
COPIEHFA_00817 1.1e-13 T PhoQ Sensor
COPIEHFA_00818 3.6e-88 T PhoQ Sensor
COPIEHFA_00819 6.7e-122 L Helix-turn-helix domain
COPIEHFA_00820 1.2e-165 L integrase core domain
COPIEHFA_00821 2.1e-30 rpsT J rRNA binding
COPIEHFA_00822 1.2e-171 coaA 2.7.1.33 F Pantothenic acid kinase
COPIEHFA_00823 1.8e-107 rsmC 2.1.1.172 J Methyltransferase small domain protein
COPIEHFA_00824 1.2e-57 pdp 2.4.2.2, 2.4.2.4 F Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate
COPIEHFA_00825 6e-98 pdp 2.4.2.2, 2.4.2.4 F Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate
COPIEHFA_00826 1.4e-22 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
COPIEHFA_00827 7.6e-36 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
COPIEHFA_00828 2e-14 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
COPIEHFA_00829 1.3e-69 cdd 2.4.2.2, 3.5.4.5 F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
COPIEHFA_00830 9.5e-192 tcsA S ABC-type transport system, periplasmic component surface lipoprotein
COPIEHFA_00831 3.7e-282 xylG 3.6.3.17 S ABC transporter, ATP-binding protein
COPIEHFA_00832 3e-190 yufP S Belongs to the binding-protein-dependent transport system permease family
COPIEHFA_00833 1.8e-170 yufQ S Belongs to the binding-protein-dependent transport system permease family
COPIEHFA_00834 1.2e-120 ycbL 3.1.2.6 S COG0491 Zn-dependent hydrolases, including glyoxylases
COPIEHFA_00835 0.0 dinG 2.7.7.7, 3.6.4.12 L helicase involved in DNA repair and perhaps also replication
COPIEHFA_00836 6.8e-81 ypmB S Protein conserved in bacteria
COPIEHFA_00837 1.6e-216 aspB 2.6.1.1, 2.6.1.14 E Aminotransferase
COPIEHFA_00838 4.2e-261 asnS 6.1.1.22 J Catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
COPIEHFA_00839 2.5e-15
COPIEHFA_00840 6.8e-54 L Transposase
COPIEHFA_00841 2.7e-31 L Transposase
COPIEHFA_00842 3e-63 tdcF 3.5.99.10 J endoribonuclease L-PSP
COPIEHFA_00843 1.5e-123 queC 6.3.4.20 F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
COPIEHFA_00844 3.7e-81 queD 4.1.2.50, 4.2.3.12 H synthase
COPIEHFA_00845 2.5e-135 queE 1.97.1.4, 4.3.99.3 H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
COPIEHFA_00846 6.5e-95 queF 1.7.1.13 S Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily
COPIEHFA_00847 2.2e-19 D nuclear chromosome segregation
COPIEHFA_00848 1.7e-90 yejC S cyclic nucleotide-binding protein
COPIEHFA_00849 2.6e-33 yejC S cyclic nucleotide-binding protein
COPIEHFA_00850 1.2e-163 rapZ S Displays ATPase and GTPase activities
COPIEHFA_00851 6.7e-170 ybhK S Required for morphogenesis under gluconeogenic growth conditions
COPIEHFA_00852 8.7e-162 whiA K May be required for sporulation
COPIEHFA_00853 8.2e-120 pepD E Dipeptidase
COPIEHFA_00854 5.8e-41 pepD E dipeptidase activity
COPIEHFA_00855 5.4e-32 cspD K Cold shock protein domain
COPIEHFA_00856 9.4e-43 K Cold-Shock Protein
COPIEHFA_00857 3.6e-224 L Transposase, Mutator family
COPIEHFA_00858 0.0 copB 3.6.3.4 P P-type ATPase
COPIEHFA_00859 1.6e-88 L Transposase
COPIEHFA_00860 1.3e-49 L Transposase
COPIEHFA_00861 1.5e-95 cysE 2.3.1.30 E Bacterial transferase hexapeptide (six repeats)
COPIEHFA_00862 2e-219 metC 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
COPIEHFA_00863 2.3e-170 mccA 2.5.1.134, 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
COPIEHFA_00864 1.5e-194 3.1.21.3 L Subunit R is required for both nuclease and ATPase activities, but not for modification
COPIEHFA_00865 7.5e-50 L Transposase
COPIEHFA_00866 1.8e-122 L Transposase
COPIEHFA_00867 3.9e-56 hsdS 2.1.1.72, 3.1.21.3 V type I restriction modification DNA specificity domain
COPIEHFA_00868 1.9e-43 hsdM 2.1.1.72 V type I restriction-modification system
COPIEHFA_00869 4.2e-153 glcU U Glucose uptake
COPIEHFA_00870 1.1e-08 mycA 4.2.1.53 S Myosin-crossreactive antigen
COPIEHFA_00871 1.5e-79 hsdM 2.1.1.72 V HsdM N-terminal domain
COPIEHFA_00872 1.3e-88 XK27_10720 D peptidase activity
COPIEHFA_00873 3.1e-292 adcA P Belongs to the bacterial solute-binding protein 9 family
COPIEHFA_00874 1.7e-08
COPIEHFA_00876 2.1e-172 yeiH S Membrane
COPIEHFA_00877 2.1e-118 mur1 NU muramidase
COPIEHFA_00878 4.1e-83 L transposition
COPIEHFA_00879 2.6e-166 cpsY K Transcriptional regulator
COPIEHFA_00880 0.0 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
COPIEHFA_00881 2.5e-58 phnA P Alkylphosphonate utilization operon protein PhnA
COPIEHFA_00882 3.1e-105 artQ P ABC transporter (Permease
COPIEHFA_00883 1.3e-70 glnQ 3.6.3.21 E abc transporter atp-binding protein
COPIEHFA_00884 5e-27 glnQ 3.6.3.21 E abc transporter atp-binding protein
COPIEHFA_00885 2.7e-157 aatB ET ABC transporter substrate-binding protein
COPIEHFA_00886 4.8e-143 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
COPIEHFA_00887 3.4e-58 adhP 1.1.1.1 C alcohol dehydrogenase
COPIEHFA_00888 1.5e-23 adhP 1.1.1.1 C alcohol dehydrogenase
COPIEHFA_00889 4.7e-17 adhP 1.1.1.1 C alcohol dehydrogenase
COPIEHFA_00890 2.9e-31 adhP 1.1.1.1 C alcohol dehydrogenase
COPIEHFA_00892 9.3e-48 sthIM 2.1.1.72 L Adenine specific DNA methylase Mod
COPIEHFA_00893 3e-303 guaA 2.3.1.128, 6.3.5.2 F Catalyzes the synthesis of GMP from XMP
COPIEHFA_00894 1.6e-126 gntR1 K transcriptional
COPIEHFA_00895 1.1e-53 ylxM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
COPIEHFA_00896 6.1e-272 ffh 3.6.5.4 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
COPIEHFA_00897 3.1e-87 niaX
COPIEHFA_00898 6e-91 niaR S small molecule binding protein (contains 3H domain)
COPIEHFA_00899 8.1e-128 K DNA-binding helix-turn-helix protein
COPIEHFA_00900 1.1e-158 ylqF S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
COPIEHFA_00901 2.6e-135 rnhB 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
COPIEHFA_00902 4.1e-167 GK ROK family
COPIEHFA_00903 2.3e-156 dprA LU DNA protecting protein DprA
COPIEHFA_00904 0.0 topA 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
COPIEHFA_00905 1.3e-151 S TraX protein
COPIEHFA_00906 2.2e-122 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
COPIEHFA_00907 6.2e-252 T PhoQ Sensor
COPIEHFA_00908 6.6e-259 trmFO 2.1.1.74 J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
COPIEHFA_00909 2.4e-152 XK27_05470 E Methionine synthase
COPIEHFA_00910 1.7e-75 ndk 2.7.4.6 F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
COPIEHFA_00911 2.7e-48 pspE P Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
COPIEHFA_00912 1.8e-51 IQ Acetoin reductase
COPIEHFA_00913 3.9e-19 IQ Acetoin reductase
COPIEHFA_00914 0.0 lepA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
COPIEHFA_00917 6.5e-41 K peptidyl-tyrosine sulfation
COPIEHFA_00918 4.4e-155 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
COPIEHFA_00921 1.1e-212 pqqE C radical SAM domain protein
COPIEHFA_00922 3.9e-136 speB 3.5.3.11 E hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
COPIEHFA_00923 6.6e-61 EGP Major facilitator Superfamily
COPIEHFA_00924 0.0 alsS 2.2.1.6 EH Belongs to the TPP enzyme family
COPIEHFA_00925 3e-133 budA 4.1.1.5 H Belongs to the alpha-acetolactate decarboxylase family
COPIEHFA_00926 2.9e-196 L Transposase
COPIEHFA_00927 1.4e-112 V ABC transporter (Permease
COPIEHFA_00928 4.1e-114 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
COPIEHFA_00929 1.6e-10
COPIEHFA_00930 3.4e-97 K Transcriptional regulator, TetR family
COPIEHFA_00931 1.8e-159 czcD P cation diffusion facilitator family transporter
COPIEHFA_00932 2.7e-210 hemH 4.99.1.1, 4.99.1.9 H Catalyzes the ferrous insertion into protoporphyrin IX
COPIEHFA_00933 8.6e-131 adhB 1.1.1.1, 1.1.1.14 E Dehydrogenase
COPIEHFA_00934 2.6e-39 adhB 1.1.1.1, 1.1.1.14 E Dehydrogenase
COPIEHFA_00935 6e-08 S Hydrolases of the alpha beta superfamily
COPIEHFA_00936 7.9e-17 S Alpha/beta hydrolase of unknown function (DUF915)
COPIEHFA_00937 3.8e-78 S Alpha/beta hydrolase of unknown function (DUF915)
COPIEHFA_00940 2.6e-143 2.4.2.3 F Phosphorylase superfamily
COPIEHFA_00941 4.1e-118 gph 3.1.3.18 S HAD hydrolase, family IA, variant 1
COPIEHFA_00942 9.4e-15 yclQ P ABC-type enterochelin transport system, periplasmic component
COPIEHFA_00943 3.3e-19 yclQ P ABC-type enterochelin transport system, periplasmic component
COPIEHFA_00944 6.6e-73 dinF V Mate efflux family protein
COPIEHFA_00945 4.8e-41 dinF V Mate efflux family protein
COPIEHFA_00947 2.3e-309 FbpA K RNA-binding protein homologous to eukaryotic snRNP
COPIEHFA_00948 3.7e-190
COPIEHFA_00949 3.1e-89 FNV0100 F Belongs to the Nudix hydrolase family
COPIEHFA_00950 3.5e-28 3.4.13.21 I Protein conserved in bacteria
COPIEHFA_00952 5.7e-118 S TraX protein
COPIEHFA_00953 1.3e-96 thiJ 2.7.11.1, 3.5.1.124 S DJ-1 family
COPIEHFA_00954 1.3e-148 pyrK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )
COPIEHFA_00955 3.2e-175 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
COPIEHFA_00956 1.2e-14 cas1 L maintenance of DNA repeat elements
COPIEHFA_00957 7.4e-158 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
COPIEHFA_00958 3.7e-54 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
COPIEHFA_00959 6.8e-133 cas6 S Pfam:DUF2276
COPIEHFA_00960 0.0 csm1 S CRISPR-associated protein Csm1 family
COPIEHFA_00961 5.6e-62 csm2 L Pfam:DUF310
COPIEHFA_00962 1.1e-116 csm3 L RAMP superfamily
COPIEHFA_00963 5.8e-166 csm4 L CRISPR-associated RAMP protein, Csm4 family
COPIEHFA_00964 4.4e-205 csm5 L CRISPR-associated RAMP protein, Csm5 family
COPIEHFA_00965 2.1e-14 csm6 S Psort location Cytoplasmic, score
COPIEHFA_00966 5.2e-74 csm6 S Psort location Cytoplasmic, score
COPIEHFA_00967 7e-127 pyrF 4.1.1.23 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
COPIEHFA_00968 7.5e-112 pyrE 2.4.2.10, 4.1.1.23 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
COPIEHFA_00969 1.2e-63 nylA 3.5.1.4 J Belongs to the amidase family
COPIEHFA_00971 1.1e-267 dtpT E transporter
COPIEHFA_00972 1e-103 nylA 3.5.1.4 J Belongs to the amidase family
COPIEHFA_00973 8.8e-134 yckB ET Belongs to the bacterial solute-binding protein 3 family
COPIEHFA_00974 3.5e-68 yecS P ABC transporter (Permease
COPIEHFA_00976 8.1e-114 sasH 3.1.3.5, 3.6.1.45 F Belongs to the 5'-nucleotidase family
COPIEHFA_00977 2.7e-58 sasH 3.1.3.5, 3.6.1.45 F Belongs to the 5'-nucleotidase family
COPIEHFA_00978 7.6e-64 yfiF3 K sequence-specific DNA binding
COPIEHFA_00979 4e-22 bglC K Transcriptional regulator
COPIEHFA_00980 1.3e-246 mnmE S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
COPIEHFA_00981 1.2e-239 agcS E (Alanine) symporter
COPIEHFA_00982 0.0 pcrA 3.6.4.12 L ATP-dependent DNA helicase
COPIEHFA_00983 3.5e-241 metY 2.5.1.49 E o-acetylhomoserine
COPIEHFA_00984 1.8e-59 Q phosphatase activity
COPIEHFA_00985 9.3e-62 S haloacid dehalogenase-like hydrolase
COPIEHFA_00986 3.5e-88 tpx 1.11.1.15 O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
COPIEHFA_00987 1.1e-110 hsdS2 2.1.1.72 V Type I restriction modification DNA specificity domain
COPIEHFA_00988 7.3e-138 XK27_04775 S hemerythrin HHE cation binding domain
COPIEHFA_00989 5.2e-22 XK27_04775 P Hemerythrin HHE cation binding domain protein
COPIEHFA_00990 2.4e-150 truB 5.4.99.25 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
COPIEHFA_00991 4.9e-173 ribF 2.7.1.26, 2.7.7.2 H Belongs to the ribF family
COPIEHFA_00992 1.4e-71 spxA 1.20.4.1 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
COPIEHFA_00993 8.7e-44 yktA S Belongs to the UPF0223 family
COPIEHFA_00994 1.9e-141 suhB 3.1.3.25 G Belongs to the inositol monophosphatase superfamily
COPIEHFA_00995 3e-157 rsmF 2.1.1.176, 2.1.1.178 J NOL1 NOP2 sun family protein
COPIEHFA_00996 4.3e-158 pstS P phosphate
COPIEHFA_00997 1.8e-154 pstC P probably responsible for the translocation of the substrate across the membrane
COPIEHFA_00998 1.2e-155 pstA P phosphate transport system permease
COPIEHFA_00999 5.2e-150 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
COPIEHFA_01000 1.9e-138 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
COPIEHFA_01001 2.4e-113 phoU P Plays a role in the regulation of phosphate uptake
COPIEHFA_01002 0.0 pepN 3.4.11.2 E aminopeptidase
COPIEHFA_01003 7e-195 xerS D Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division
COPIEHFA_01004 1.3e-187 lplA 6.3.1.20 H Lipoate-protein ligase
COPIEHFA_01005 1.1e-17
COPIEHFA_01006 3.7e-09
COPIEHFA_01007 0.0 glgP 2.4.1.1 GT35 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
COPIEHFA_01008 6.9e-297 malQ 2.4.1.25 GH77 G 4-alpha-glucanotransferase
COPIEHFA_01009 2.3e-23 L Transposase
COPIEHFA_01010 4.6e-25 tatA U protein secretion
COPIEHFA_01011 2e-121 tatC U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
COPIEHFA_01012 5.3e-298 ywbL P COG0672 High-affinity Fe2 Pb2 permease
COPIEHFA_01013 1.5e-233 ycdB P peroxidase
COPIEHFA_01014 4.8e-141 ycdO P periplasmic lipoprotein involved in iron transport
COPIEHFA_01015 1.7e-177 fatB P ABC-type enterochelin transport system, periplasmic component
COPIEHFA_01016 6.8e-136 yclP 3.6.3.34 P abc transporter atp-binding protein
COPIEHFA_01017 1.9e-167 fatC P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
COPIEHFA_01018 4e-165 yclN P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
COPIEHFA_01019 2e-139 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
COPIEHFA_01020 3.8e-54 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
COPIEHFA_01021 7.3e-143 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
COPIEHFA_01022 0.0 3.5.1.28 NU amidase activity
COPIEHFA_01023 3.6e-82 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
COPIEHFA_01024 2.6e-20 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
COPIEHFA_01025 0.0 lpdA 1.8.1.4 C Dehydrogenase
COPIEHFA_01026 1.8e-198 acoC 2.3.1.12 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
COPIEHFA_01027 3.7e-182 acoB 1.2.4.1, 1.2.4.4 C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
COPIEHFA_01028 6e-185 acoA 1.2.4.1, 1.2.4.4 C Dehydrogenase E1 component
COPIEHFA_01029 0.0 S the current gene model (or a revised gene model) may contain a frame shift
COPIEHFA_01030 2.4e-234 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
COPIEHFA_01031 7.7e-128 ung 3.2.2.27 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
COPIEHFA_01032 3.3e-217 yeaB K Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
COPIEHFA_01033 1.3e-159 rssA S Phospholipase, patatin family
COPIEHFA_01034 3.9e-78 estA E GDSL-like protein
COPIEHFA_01035 2.6e-15 estA E Lysophospholipase L1 and related esterases
COPIEHFA_01036 1.2e-291 S unusual protein kinase
COPIEHFA_01037 4.9e-39 S granule-associated protein
COPIEHFA_01038 1.2e-35 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
COPIEHFA_01039 3.8e-96 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
COPIEHFA_01040 2e-18 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
COPIEHFA_01041 1.3e-199 S hmm pf01594
COPIEHFA_01042 7.8e-101 G Belongs to the phosphoglycerate mutase family
COPIEHFA_01043 2.6e-70 supH 3.1.3.102, 3.1.3.104 S Sucrose-6F-phosphate phosphohydrolase
COPIEHFA_01044 2.2e-94 V VanZ like family
COPIEHFA_01045 3e-31
COPIEHFA_01046 1.6e-73 L Transposase
COPIEHFA_01047 8.6e-241 cps1C S Polysaccharide biosynthesis protein
COPIEHFA_01048 2.4e-46 tnp L DDE domain
COPIEHFA_01049 2.6e-95 2.7.8.12 GT2 S Glycosyltransferase like family 2
COPIEHFA_01050 2.1e-55 M Glycosyltransferase like family 2
COPIEHFA_01051 8.1e-13 wzy P EpsG family
COPIEHFA_01052 1.8e-92 lsgC M Glycosyl transferases group 1
COPIEHFA_01053 6.3e-213 rgpAc GT4 M Domain of unknown function (DUF1972)
COPIEHFA_01054 1.6e-103 rfbP 2.7.8.6 M Bacterial sugar transferase
COPIEHFA_01055 3.3e-221 cpsE M Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
COPIEHFA_01056 1.1e-114 cpsD D COG0489 ATPases involved in chromosome partitioning
COPIEHFA_01057 1.1e-103 cps4C M biosynthesis protein
COPIEHFA_01058 2.5e-135 cpsB 3.1.3.48 GM Capsular polysaccharide biosynthesis protein
COPIEHFA_01059 3.6e-250 cps4A K Cell envelope-like function transcriptional attenuator common domain protein
COPIEHFA_01060 6.9e-130 deoD 2.4.2.1, 2.4.2.28 F purine nucleoside phosphorylase
COPIEHFA_01061 1.5e-56 yfeJ 6.3.5.2 F glutamine amidotransferase
COPIEHFA_01062 1.7e-12 yfeJ 6.3.5.2 F glutamine amidotransferase
COPIEHFA_01063 1.4e-137 clcA_2 P chloride
COPIEHFA_01064 3.4e-149 punA 2.4.2.1 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
COPIEHFA_01065 7.1e-236 deoB 5.4.2.7 G Phosphotransfer between the C1 and C5 carbon atoms of pentose
COPIEHFA_01066 1.7e-122 rpiA 2.7.1.12, 2.7.1.15, 5.3.1.6 G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
COPIEHFA_01068 4e-21 V Glucan-binding protein C
COPIEHFA_01069 1e-110 ung2 3.2.2.27 L Uracil-DNA glycosylase
COPIEHFA_01070 2.4e-275 pepV 3.5.1.18 E Dipeptidase
COPIEHFA_01071 6.4e-27 dmpI 5.3.2.6 G Belongs to the 4-oxalocrotonate tautomerase family
COPIEHFA_01072 3.4e-48 XK27_03610 K Gnat family
COPIEHFA_01073 4.8e-16 XK27_03610 K Gnat family
COPIEHFA_01074 1.5e-56 rplT J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
COPIEHFA_01075 2.1e-28 rpmI J Belongs to the bacterial ribosomal protein bL35 family
COPIEHFA_01076 9.8e-89 infC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
COPIEHFA_01077 1.1e-121 cmk 1.17.7.4, 2.5.1.19, 2.7.1.26, 2.7.4.25, 2.7.7.2, 6.3.2.1 F Belongs to the cytidylate kinase family. Type 1 subfamily
COPIEHFA_01078 5e-23 M LysM domain
COPIEHFA_01079 1.4e-89 ebsA S Family of unknown function (DUF5322)
COPIEHFA_01080 6.7e-234 pepT 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
COPIEHFA_01081 5.1e-96 lepB 3.4.21.89 U Belongs to the peptidase S26 family
COPIEHFA_01082 4.9e-224 G COG0457 FOG TPR repeat
COPIEHFA_01083 1.2e-174 yubA S permease
COPIEHFA_01084 1.7e-92 mutX 3.6.1.55 F NTP pyrophosphohydrolases including oxidative damage repair enzymes
COPIEHFA_01085 8.1e-163 ftsX D Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation
COPIEHFA_01086 2.5e-124 ftsE D cell division ATP-binding protein FtsE
COPIEHFA_01087 1.6e-182 prfB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
COPIEHFA_01088 1.2e-202 queG 1.17.99.6 C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
COPIEHFA_01089 1.3e-181 yjjH S Calcineurin-like phosphoesterase
COPIEHFA_01090 6.7e-136 nfrA 1.5.1.38, 1.5.1.39 C nitroreductase
COPIEHFA_01091 0.0 pacL 3.6.3.8 P cation transport ATPase
COPIEHFA_01092 2.6e-67 ywiB S Domain of unknown function (DUF1934)
COPIEHFA_01093 9.1e-50 XK27_00115 2.3.1.128 K acetyltransferase
COPIEHFA_01094 9.2e-147 yidA S hydrolases of the HAD superfamily
COPIEHFA_01095 9e-231 murM 2.3.2.10, 2.3.2.16 V protein involved in methicillin resistance
COPIEHFA_01096 1.5e-34 F Protein of unknown function (DUF454)
COPIEHFA_01097 4.6e-154 vicX 3.1.26.11 S Metal-dependent hydrolases of the beta-lactamase superfamily I
COPIEHFA_01098 5.8e-247 vicK 2.7.13.3 T Histidine kinase
COPIEHFA_01099 9.9e-129 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
COPIEHFA_01100 2.1e-140 glnQ 3.6.3.21 E abc transporter atp-binding protein
COPIEHFA_01101 1.6e-149 peb1A ET ABC-type amino acid transport signal transduction systems, periplasmic component domain
COPIEHFA_01102 8e-115 gltJ P ABC transporter (Permease
COPIEHFA_01103 4.2e-110 tcyB_2 P ABC transporter (permease)
COPIEHFA_01104 1.6e-123 endA F DNA RNA non-specific endonuclease
COPIEHFA_01105 1.2e-25 epuA S DNA-directed RNA polymerase subunit beta
COPIEHFA_01106 1.6e-230 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
COPIEHFA_01108 1.5e-194 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
COPIEHFA_01109 4.9e-20 G Domain of unknown function (DUF4832)
COPIEHFA_01110 2.1e-203 metK 2.5.1.6 H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
COPIEHFA_01111 4.2e-175 birA 6.3.4.15 HK Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
COPIEHFA_01112 3.2e-295 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
COPIEHFA_01113 6.1e-88 ytsP 1.8.4.14 T GAF domain-containing protein
COPIEHFA_01114 4.2e-89 miaA 2.5.1.75 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
COPIEHFA_01115 3.7e-58 miaA 2.5.1.75 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
COPIEHFA_01116 1.2e-19 WQ51_02665 S Protein of unknown function (DUF3042)
COPIEHFA_01120 8.5e-57 rplS J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
COPIEHFA_01121 2.6e-217 XK27_05110 P chloride
COPIEHFA_01122 9.6e-40 pheA 1.3.1.12, 2.3.1.79, 4.2.1.51, 5.4.99.5 E Chorismate mutase
COPIEHFA_01123 9.2e-281 clcA P Chloride transporter, ClC family
COPIEHFA_01124 5.1e-75 fld C Flavodoxin
COPIEHFA_01125 2.5e-14 XK27_08880
COPIEHFA_01126 4.7e-126 XK27_08875 O Zinc-dependent metalloprotease
COPIEHFA_01127 1.6e-151 estA CE1 S Putative esterase
COPIEHFA_01128 1e-309 rnjB S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
COPIEHFA_01129 4.4e-135 XK27_08845 S abc transporter atp-binding protein
COPIEHFA_01130 8.9e-148 XK27_08840 S Belongs to the binding-protein-dependent transport system permease family
COPIEHFA_01131 1.9e-173 XK27_08835 S ABC transporter substrate binding protein
COPIEHFA_01132 3.2e-17 S Domain of unknown function (DUF4649)
COPIEHFA_01133 3.7e-31 Q the current gene model (or a revised gene model) may contain a frame shift
COPIEHFA_01134 6.3e-28 Q the current gene model (or a revised gene model) may contain a frame shift
COPIEHFA_01136 3.2e-09 Q the current gene model (or a revised gene model) may contain a frame shift
COPIEHFA_01138 5e-216 L Transposase
COPIEHFA_01139 1.3e-276 pyk 2.7.1.40, 2.7.7.4 G Belongs to the pyruvate kinase family
COPIEHFA_01140 1.2e-188 pfkA 2.7.1.11 F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
COPIEHFA_01141 0.0 dnaE 2.7.7.7 L DNA polymerase
COPIEHFA_01142 1.4e-152 sua5 2.7.7.87 J Belongs to the SUA5 family
COPIEHFA_01143 3.1e-112 leuD 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
COPIEHFA_01144 6.8e-275 leuC 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
COPIEHFA_01145 2.5e-43 ysdA L Membrane
COPIEHFA_01146 6.6e-190 leuB 1.1.1.85 CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
COPIEHFA_01147 3.4e-291 leuA 2.3.3.13 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
COPIEHFA_01148 4.6e-131 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
COPIEHFA_01149 1.6e-179 pyrD 1.3.1.14, 1.3.98.1 F Catalyzes the conversion of dihydroorotate to orotate
COPIEHFA_01151 2.8e-39 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
COPIEHFA_01152 5.1e-83 ypmS S Protein conserved in bacteria
COPIEHFA_01153 3.9e-143 ypmR E lipolytic protein G-D-S-L family
COPIEHFA_01154 3e-148 DegV S DegV family
COPIEHFA_01155 9.9e-305 recN L May be involved in recombinational repair of damaged DNA
COPIEHFA_01156 1.8e-72 argR K Regulates arginine biosynthesis genes
COPIEHFA_01157 5e-159 rrmJ 2.1.1.226, 2.1.1.227 J Ribosomal RNA large subunit methyltransferase J
COPIEHFA_01158 3e-159 ispA 2.5.1.1, 2.5.1.10, 2.5.1.29, 2.5.1.90 H Belongs to the FPP GGPP synthase family
COPIEHFA_01159 3.5e-29 xseB 3.1.11.6 L exodeoxyribonuclease VII activity
COPIEHFA_01160 1.2e-247 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
COPIEHFA_01162 3.4e-120 nth 4.2.99.18 L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
COPIEHFA_01163 3.8e-125 dnaD
COPIEHFA_01164 9.3e-183 metA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
COPIEHFA_01165 2e-94 apt 2.4.2.22, 2.4.2.7 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
COPIEHFA_01166 0.0 recJ L Single-strand DNA-specific exonuclease, C terminal domain
COPIEHFA_01167 6.7e-139 XK27_05435 1.1.1.100 S Belongs to the short-chain dehydrogenases reductases (SDR) family
COPIEHFA_01168 9.2e-175 rnz 3.1.26.11 S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
COPIEHFA_01169 4.2e-118 galT 2.7.7.12 G UDPglucose--hexose-1-phosphate uridylyltransferase
COPIEHFA_01170 4.9e-105 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
COPIEHFA_01171 2.9e-72 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
COPIEHFA_01172 3.6e-239 rodA D Belongs to the SEDS family
COPIEHFA_01173 4.5e-49 hisE 3.5.4.19, 3.6.1.31, 5.3.1.16 E phosphoribosyl-ATP diphosphatase activity
COPIEHFA_01174 5.5e-61 hisI 3.5.4.19, 3.5.4.25, 3.6.1.31, 5.3.1.16 E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
COPIEHFA_01175 1.9e-133 hisF 3.5.4.19, 3.6.1.31 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
COPIEHFA_01176 5e-128 hisA 5.3.1.16 E 1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
COPIEHFA_01177 1.2e-109 hisH E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
COPIEHFA_01178 1.5e-106 hisB 1.1.1.23, 2.6.1.9, 3.1.3.15, 4.2.1.19 E imidazoleglycerol-phosphate dehydratase
COPIEHFA_01179 2.4e-234 hisD 1.1.1.23, 1.1.1.308 E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
COPIEHFA_01180 8e-117 hisG 2.4.2.17 E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
COPIEHFA_01181 1.5e-183 hisZ 2.4.2.17, 6.1.1.21 E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
COPIEHFA_01182 4.1e-195 hisC 2.6.1.9 E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
COPIEHFA_01184 2.9e-87 L Integrase core domain protein
COPIEHFA_01185 1.1e-53 L transposition
COPIEHFA_01186 1.8e-21 L Transposase
COPIEHFA_01187 5.2e-36 L transposase activity
COPIEHFA_01188 4.9e-33 XK27_08085
COPIEHFA_01189 1e-88 XK27_08080 3.1.1.53 G Exopolysaccharide biosynthesis protein
COPIEHFA_01190 2.5e-08 XK27_08080 3.1.1.53 G Exopolysaccharide biosynthesis protein
COPIEHFA_01191 2e-140 hisK 3.1.3.15 E Histidinol phosphatase and related hydrolases of the PHP family
COPIEHFA_01192 1.1e-121 ylfI S tigr01906
COPIEHFA_01193 5.9e-143 nagD 2.7.1.25, 3.1.3.41 G Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
COPIEHFA_01194 1.5e-143 fat 3.1.2.21 I Acyl-ACP thioesterase
COPIEHFA_01195 4.1e-217 hemN H Involved in the biosynthesis of porphyrin-containing compound
COPIEHFA_01198 4.8e-204 rfbB 4.2.1.46 M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
COPIEHFA_01199 8.3e-113 rmlC 1.1.1.133, 5.1.3.13 M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
COPIEHFA_01200 1.9e-161 rfbA 2.7.7.24 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
COPIEHFA_01201 6.3e-207 yurR 1.4.5.1 E oxidoreductase
COPIEHFA_01202 6.4e-29 zupT P transporter
COPIEHFA_01203 2.3e-14 zupT P Mediates zinc uptake. May also transport other divalent cations
COPIEHFA_01204 8.1e-148 yqfO 3.5.4.16 S Belongs to the GTP cyclohydrolase I type 2 NIF3 family
COPIEHFA_01205 7.9e-123 trmK 2.1.1.217 S SAM-dependent methyltransferase
COPIEHFA_01206 1.7e-70 gtrA S GtrA-like protein
COPIEHFA_01207 1.5e-250 glmM 5.4.2.10 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
COPIEHFA_01208 1.7e-168 ybbR S Protein conserved in bacteria
COPIEHFA_01209 5.6e-124 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
COPIEHFA_01210 1.1e-146 murD 3.4.21.10, 6.3.2.13, 6.3.2.9 M Mur ligase, middle domain protein
COPIEHFA_01211 5.7e-61 murD 3.4.21.10, 6.3.2.13, 6.3.2.9 M Mur ligase, middle domain protein
COPIEHFA_01212 8.7e-150 cobQ S glutamine amidotransferase
COPIEHFA_01213 3.9e-164 mprF 2.3.2.3 J Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
COPIEHFA_01214 3.1e-287 mprF 2.3.2.3 J Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
COPIEHFA_01215 2.2e-131 pip 1.11.1.10 S Alpha beta hydrolase
COPIEHFA_01216 0.0 uup S abc transporter atp-binding protein
COPIEHFA_01217 2.1e-114 udk 2.7.1.48 F Cytidine monophosphokinase
COPIEHFA_01218 2.1e-178 yfmL 3.6.4.13 L DEAD DEAH box helicase
COPIEHFA_01219 2.1e-28 6.3.2.2, 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
COPIEHFA_01220 8.6e-265 gapN 1.2.1.9 C Belongs to the aldehyde dehydrogenase family
COPIEHFA_01221 1.6e-249 L Transposase
COPIEHFA_01222 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
COPIEHFA_01223 7.9e-39 ptsH G phosphocarrier protein Hpr
COPIEHFA_01224 2.3e-223 icd 1.1.1.42 C Isocitrate dehydrogenase
COPIEHFA_01225 9.6e-211 citZ 2.3.3.1 C Belongs to the citrate synthase family
COPIEHFA_01226 0.0 acnA 4.2.1.3 C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
COPIEHFA_01227 2.2e-34 nrdH O Glutaredoxin
COPIEHFA_01228 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
COPIEHFA_01229 1.7e-184 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
COPIEHFA_01231 6.2e-65 L Transposase (IS116 IS110 IS902 family)
COPIEHFA_01232 3.6e-61 L Transposase (IS116 IS110 IS902 family)
COPIEHFA_01233 1.8e-165 ypuA S secreted protein
COPIEHFA_01234 1.1e-55 yaeR E COG0346 LactoylglutaTHIone lyase and related lyases
COPIEHFA_01235 5.1e-131 srtA 3.4.22.70 M Sortase (surface protein transpeptidase)
COPIEHFA_01236 0.0 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
COPIEHFA_01237 1.1e-181 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
COPIEHFA_01238 3.4e-258 noxE P NADH oxidase
COPIEHFA_01239 1.9e-294 yfmM S abc transporter atp-binding protein
COPIEHFA_01240 3.3e-82 XK27_01265 S ECF-type riboflavin transporter, S component
COPIEHFA_01241 8.7e-85 pdxK 2.7.1.35 H Belongs to the pyridoxine kinase family
COPIEHFA_01242 4.5e-44 pdxK 2.7.1.35 H Belongs to the pyridoxine kinase family
COPIEHFA_01243 2e-86 S ECF-type riboflavin transporter, S component
COPIEHFA_01245 2.9e-240 XK27_08130 K Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
COPIEHFA_01246 2e-55 nrdD_1 1.1.98.6, 1.17.4.1 F Ribonucleoside-triphosphate reductase
COPIEHFA_01249 0.0 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
COPIEHFA_01250 9.9e-94 paiA 2.3.1.57 K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
COPIEHFA_01251 3.3e-197 pheS 6.1.1.20 J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
COPIEHFA_01252 0.0 smc D Required for chromosome condensation and partitioning
COPIEHFA_01253 1.9e-124 rnc 3.1.26.3 J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
COPIEHFA_01254 6.6e-173 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
COPIEHFA_01255 7.3e-200 asd 1.2.1.11 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
COPIEHFA_01256 6.8e-80 alkD L Dna alkylation repair
COPIEHFA_01257 2.4e-92 pat 2.3.1.183 M acetyltransferase
COPIEHFA_01258 1.6e-11 L Transposase
COPIEHFA_01259 8.4e-276 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
COPIEHFA_01260 0.0 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
COPIEHFA_01261 1.6e-118 yjjG 3.1.3.102, 3.1.3.104, 3.1.3.5, 3.8.1.2 E hydrolase
COPIEHFA_01262 1.2e-62 bioY S biotin transmembrane transporter activity
COPIEHFA_01263 9.8e-88 proW P Binding-protein-dependent transport system inner membrane component
COPIEHFA_01264 1.6e-137 proV E abc transporter atp-binding protein
COPIEHFA_01265 3.8e-165 proX M ABC transporter, substrate-binding protein, QAT family
COPIEHFA_01266 4.3e-102 proWZ P ABC transporter (Permease
COPIEHFA_01267 2.5e-278 hutH 4.3.1.3 E Histidine ammonia-lyase
COPIEHFA_01268 1.6e-205 S Protein of unknown function (DUF917)
COPIEHFA_01269 7.2e-308 hutU 4.2.1.49 E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
COPIEHFA_01270 4.6e-59 sdaAB 4.3.1.17 E L-serine dehydratase
COPIEHFA_01271 1.3e-100 desR K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
COPIEHFA_01272 4.5e-189 desK 2.7.13.3 T Histidine kinase
COPIEHFA_01273 1.1e-130 yvfS V ABC-2 type transporter
COPIEHFA_01274 2.2e-157 XK27_09825 V abc transporter atp-binding protein
COPIEHFA_01277 2.5e-164 yocS S Transporter
COPIEHFA_01278 2.2e-81 cdd 2.4.2.4, 3.5.4.5 F cytidine deaminase activity
COPIEHFA_01279 7.5e-115 yvfS V Transporter
COPIEHFA_01280 2.7e-152 XK27_09825 V abc transporter atp-binding protein
COPIEHFA_01281 1.6e-14 liaI KT membrane
COPIEHFA_01282 2.6e-30 liaI KT membrane
COPIEHFA_01283 6e-99 XK27_05000 S Fe-S-cluster oxidoreductase
COPIEHFA_01284 0.0 V ABC transporter (permease)
COPIEHFA_01285 1.9e-133 macB2 V ABC transporter, ATP-binding protein
COPIEHFA_01286 6.2e-166 T Histidine kinase
COPIEHFA_01287 6.6e-122 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
COPIEHFA_01288 5.4e-78 xpt 2.4.2.22, 2.4.2.7 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
COPIEHFA_01289 1.2e-214 pbuX F xanthine permease
COPIEHFA_01290 1.5e-247 norM V Multidrug efflux pump
COPIEHFA_01291 9e-186 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
COPIEHFA_01292 1.2e-233 brnQ E Component of the transport system for branched-chain amino acids
COPIEHFA_01293 4.2e-65 manA 5.3.1.8 G mannose-6-phosphate isomerase
COPIEHFA_01294 8.2e-57 manA 5.3.1.8 G mannose-6-phosphate isomerase
COPIEHFA_01295 4.8e-25 csbD K CsbD-like
COPIEHFA_01296 1.8e-227 yfnA E amino acid
COPIEHFA_01297 5.7e-109 XK27_02070 S nitroreductase
COPIEHFA_01298 9.5e-150 1.13.11.2 S glyoxalase
COPIEHFA_01299 1.1e-75 ywnA K Transcriptional regulator
COPIEHFA_01300 8.6e-159 E Alpha/beta hydrolase of unknown function (DUF915)
COPIEHFA_01301 1.9e-231 pts13C G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
COPIEHFA_01302 1.4e-110 drgA C Nitroreductase
COPIEHFA_01303 6.6e-102 yoaK S Protein of unknown function (DUF1275)
COPIEHFA_01304 1.5e-160 yvgN C reductase
COPIEHFA_01305 2.7e-182 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
COPIEHFA_01306 5.8e-280 XK27_07020 S Belongs to the UPF0371 family
COPIEHFA_01308 1.1e-35 BP1961 P nitric oxide dioxygenase activity
COPIEHFA_01309 9.1e-54 K response regulator
COPIEHFA_01310 1.3e-30 S Signal peptide protein, YSIRK family
COPIEHFA_01312 1.6e-58
COPIEHFA_01313 4.1e-195 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
COPIEHFA_01314 2.8e-27 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
COPIEHFA_01315 3.4e-97
COPIEHFA_01316 5.3e-12 IQ PFAM AMP-dependent synthetase and ligase
COPIEHFA_01317 2.7e-12 IQ PFAM AMP-dependent synthetase and ligase
COPIEHFA_01318 5.8e-109 MA20_06410 E LysE type translocator
COPIEHFA_01319 5.6e-08
COPIEHFA_01320 2.7e-09
COPIEHFA_01321 0.0 M family 8
COPIEHFA_01322 2e-162 hrtB V MacB-like periplasmic core domain
COPIEHFA_01323 4.1e-116 devA 3.6.3.25 V abc transporter atp-binding protein
COPIEHFA_01324 1.1e-14
COPIEHFA_01325 0.0 sbcC L ATPase involved in DNA repair
COPIEHFA_01326 1.5e-230 sbcD L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
COPIEHFA_01327 0.0 lacL 3.2.1.23 G -beta-galactosidase
COPIEHFA_01328 0.0 lacS G transporter
COPIEHFA_01329 2.4e-200 galM 5.1.3.3 G Catalyzes the interconversion of alpha and beta anomers of maltose
COPIEHFA_01330 1.1e-194 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
COPIEHFA_01331 1.3e-287 galT 2.7.7.12 G UDPglucose--hexose-1-phosphate uridylyltransferase
COPIEHFA_01332 1.2e-219 galK 2.7.1.6 G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
COPIEHFA_01333 1.7e-182 galR K Transcriptional regulator
COPIEHFA_01334 2.7e-08 L Integrase core domain protein
COPIEHFA_01335 1.2e-25 L transposition
COPIEHFA_01336 1.3e-227 zmpB M M26 IgA1-specific Metallo-endopeptidase C-terminal region
COPIEHFA_01337 6.7e-17 rtxA M M26 IgA1-specific Metallo-endopeptidase C-terminal region
COPIEHFA_01338 2.5e-101 V abc transporter atp-binding protein
COPIEHFA_01339 4.3e-40 V abc transporter atp-binding protein
COPIEHFA_01340 0.0 gshF 6.3.2.2, 6.3.2.29, 6.3.2.30, 6.3.2.4 H Belongs to the glutamate--cysteine ligase type 1 family
COPIEHFA_01341 2.3e-87 L Transposase
COPIEHFA_01342 0.0 ftsK D Belongs to the FtsK SpoIIIE SftA family
COPIEHFA_01343 6.6e-187 trxB1 1.18.1.2, 1.19.1.1 C Ferredoxin--NADP reductase
COPIEHFA_01344 1.4e-135 trmD 2.1.1.228, 4.6.1.12 J Belongs to the RNA methyltransferase TrmD family
COPIEHFA_01345 5.8e-94 rimM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
COPIEHFA_01348 2.2e-114 vraR K Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
COPIEHFA_01349 5.8e-175 vraS 2.7.13.3 T Histidine kinase
COPIEHFA_01350 1.7e-103 yvqF KT membrane
COPIEHFA_01351 1.7e-305 prkC 2.7.11.1 KLT serine threonine protein kinase
COPIEHFA_01352 2.9e-131 stp 3.1.3.16 T phosphatase
COPIEHFA_01353 8.1e-238 sun 2.1.1.176 J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
COPIEHFA_01354 9.5e-172 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
COPIEHFA_01355 0.0 priA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
COPIEHFA_01356 2.7e-46 rpoZ 2.7.7.6 K DNA-directed 5'-3' RNA polymerase activity
COPIEHFA_01357 4.8e-111 gmk 2.7.4.8 F Essential for recycling GMP and indirectly, cGMP
COPIEHFA_01358 2.8e-212 ftsY U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
COPIEHFA_01359 6.9e-150 XK27_02985 S overlaps another CDS with the same product name
COPIEHFA_01360 2.1e-148 supH S overlaps another CDS with the same product name
COPIEHFA_01361 8.6e-63 yvoA_1 K Transcriptional
COPIEHFA_01362 9.8e-121 skfE V abc transporter atp-binding protein
COPIEHFA_01363 3.3e-133 V ATPase activity
COPIEHFA_01364 4.3e-172 oppF P Belongs to the ABC transporter superfamily
COPIEHFA_01365 2.2e-204 oppD P Belongs to the ABC transporter superfamily
COPIEHFA_01366 4.9e-168 amiD P ABC transporter (Permease
COPIEHFA_01367 2.1e-277 amiC P ABC transporter (Permease
COPIEHFA_01368 0.0 amiA E ABC transporter, substrate-binding protein, family 5
COPIEHFA_01369 1.5e-222 L Transposase
COPIEHFA_01370 9.3e-239 L Transposase
COPIEHFA_01371 0.0 amiA E ABC transporter, substrate-binding protein, family 5
COPIEHFA_01372 8.1e-45 L Transposase
COPIEHFA_01373 4.1e-158 L COG2801 Transposase and inactivated derivatives
COPIEHFA_01374 1.2e-24 oppF P Belongs to the ABC transporter superfamily
COPIEHFA_01375 3.8e-45 oppF P Belongs to the ABC transporter superfamily
COPIEHFA_01376 1.4e-40 tatD L Hydrolase, tatd
COPIEHFA_01377 6.7e-218 oxlT P COG0477 Permeases of the major facilitator superfamily
COPIEHFA_01378 1e-110 L Integrase core domain protein
COPIEHFA_01379 1.1e-23 L transposase activity
COPIEHFA_01380 8.9e-18 L transposase activity
COPIEHFA_01381 4.1e-181 pta 2.3.1.8, 3.6.3.21 C phosphate acetyltransferase
COPIEHFA_01382 1.4e-172 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 J Responsible for synthesis of pseudouridine from uracil
COPIEHFA_01383 5.4e-150 nadK 2.7.1.23 H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
COPIEHFA_01384 5.5e-121 yjbM 2.7.6.5 S Gtp pyrophosphokinase
COPIEHFA_01385 1.5e-103 yjbK S Adenylate cyclase
COPIEHFA_01386 2.7e-177 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
COPIEHFA_01387 3.2e-206 iscS 2.8.1.7 E Cysteine desulfurase
COPIEHFA_01388 1.2e-58 XK27_04120 S Putative amino acid metabolism
COPIEHFA_01389 1.7e-117 rex K Modulates transcription in response to changes in cellular NADH NAD( ) redox state
COPIEHFA_01390 1.4e-122 puuD T peptidase C26
COPIEHFA_01391 9.9e-118 radC E Belongs to the UPF0758 family
COPIEHFA_01392 0.0 rgpF M Rhamnan synthesis protein F
COPIEHFA_01393 8.2e-196 rgpEc GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
COPIEHFA_01394 8.7e-226 rgpD 3.6.3.38 P Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system
COPIEHFA_01395 2.8e-143 rgpC GM Transport permease protein
COPIEHFA_01396 2.2e-179 rgpB GT2 M Glycosyltransferase, group 2 family protein
COPIEHFA_01397 1.3e-226 rgpA GT4 M Domain of unknown function (DUF1972)
COPIEHFA_01398 5.1e-195 tagF 2.7.8.12 M Glycosyl transferase, family 2
COPIEHFA_01399 2.6e-220 amrA S polysaccharide biosynthetic process
COPIEHFA_01400 5.3e-48 XK27_09090 S Uncharacterized conserved protein (DUF2304)
COPIEHFA_01401 7.6e-126 ycbB S Glycosyl transferase family 2
COPIEHFA_01402 1.2e-160 rfbD 1.1.1.133, 5.1.3.13 M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
COPIEHFA_01403 6.4e-246
COPIEHFA_01404 1.6e-171 yfdH GT2 M COG0463, glycosyltransferases involved in cell wall biogenesis
COPIEHFA_01405 1.4e-251 M Psort location CytoplasmicMembrane, score
COPIEHFA_01406 3.4e-55 yitW K metal-sulfur cluster biosynthetic enzyme
COPIEHFA_01407 4e-201 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
COPIEHFA_01408 0.0 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
COPIEHFA_01409 5.5e-20 rpsU J Belongs to the bacterial ribosomal protein bS21 family
COPIEHFA_01410 7.9e-135 gltS ET Belongs to the bacterial solute-binding protein 3 family
COPIEHFA_01411 2.1e-202 arcT 2.6.1.1 E Aminotransferase
COPIEHFA_01412 6.5e-137 ET ABC transporter
COPIEHFA_01413 7.5e-144 ET Belongs to the bacterial solute-binding protein 3 family
COPIEHFA_01414 2.9e-84 mutT 3.6.1.55 F Nudix family
COPIEHFA_01415 0.0 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
COPIEHFA_01417 1.2e-55 V CAAX protease self-immunity
COPIEHFA_01418 7.6e-32 S CAAX amino terminal protease family protein
COPIEHFA_01419 0.0 glnP P ABC-type amino acid transport signal transduction systems periplasmic component domain
COPIEHFA_01420 1e-136 glnQ 3.6.3.21 E abc transporter atp-binding protein
COPIEHFA_01421 1.1e-16 XK27_00735
COPIEHFA_01422 1.4e-248 obg S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
COPIEHFA_01424 6.2e-134 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
COPIEHFA_01427 5.5e-65 paaI Q protein possibly involved in aromatic compounds catabolism
COPIEHFA_01428 6.6e-30 ycaO O OsmC-like protein
COPIEHFA_01430 1.7e-154 EG Permeases of the drug metabolite transporter (DMT) superfamily
COPIEHFA_01432 5.6e-110 csn2 S CRISPR-associated protein (Cas_Csn2)
COPIEHFA_01433 3.5e-52 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
COPIEHFA_01434 1.5e-163 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
COPIEHFA_01435 0.0 cas9 L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
COPIEHFA_01436 6.7e-116 serB 3.1.3.3 E phosphoserine phosphatase
COPIEHFA_01437 3.2e-298 ezrA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
COPIEHFA_01438 0.0 gyrB 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
COPIEHFA_01439 2.8e-108 3.1.3.18 S IA, variant 1
COPIEHFA_01440 2.2e-117 lrgB M effector of murein hydrolase
COPIEHFA_01441 7.7e-56 lrgA S Effector of murein hydrolase LrgA
COPIEHFA_01443 6.4e-60 arsC 1.20.4.1 P Belongs to the ArsC family
COPIEHFA_01444 3.1e-56 ogt 2.1.1.63, 3.2.2.20 L methylated-DNA-[protein]-cysteine S-methyltransferase activity
COPIEHFA_01445 5.3e-220 serA 1.1.1.399, 1.1.1.95 EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
COPIEHFA_01446 1.3e-104 wecD M Acetyltransferase (GNAT) domain
COPIEHFA_01447 1.3e-209 serC 2.6.1.52 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
COPIEHFA_01448 5.1e-96 GK ROK family
COPIEHFA_01449 8.1e-72 gloA 4.4.1.5 E Lactoylglutathione lyase
COPIEHFA_01450 1.7e-47 XK27_08050 O stress-induced mitochondrial fusion
COPIEHFA_01451 1.3e-19 XK27_08050 O HflC and HflK could regulate a protease
COPIEHFA_01452 2.3e-206 potD P spermidine putrescine ABC transporter
COPIEHFA_01453 3e-134 potC P ABC-type spermidine putrescine transport system, permease component II
COPIEHFA_01454 3.7e-140 potB P ABC-type spermidine putrescine transport system, permease component I
COPIEHFA_01455 1.2e-213 potA 3.6.3.30, 3.6.3.31 P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
COPIEHFA_01456 7.8e-171 murB 1.3.1.98 M cell wall formation
COPIEHFA_01457 2.9e-87 folK 2.7.6.3, 4.1.2.25 H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
COPIEHFA_01458 1.2e-61 folB 1.13.11.81, 2.5.1.15, 2.7.6.3, 4.1.2.25, 5.1.99.8 H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
COPIEHFA_01459 7.8e-298 amy 3.2.1.1 GH13 G Belongs to the glycosyl hydrolase 13 family
COPIEHFA_01460 1.2e-146 folP 2.5.1.15, 2.7.6.3 H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
COPIEHFA_01461 1e-99 folE 3.5.4.16 F gtp cyclohydrolase
COPIEHFA_01462 0.0 ydaO E amino acid
COPIEHFA_01463 4.2e-239 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
COPIEHFA_01464 4.1e-37 ylqC L Belongs to the UPF0109 family
COPIEHFA_01465 2.4e-43 rpsP J Belongs to the bacterial ribosomal protein bS16 family
COPIEHFA_01466 1.4e-50 tehB 2.1.1.265 Q Methyltransferase
COPIEHFA_01467 3.7e-25 tehB 2.1.1.265 Q Methyltransferase
COPIEHFA_01468 1e-72 tehB 2.1.1.265 PQ tellurite resistance protein tehb
COPIEHFA_01469 8.2e-159 xth 3.1.11.2 L exodeoxyribonuclease III
COPIEHFA_01470 2.1e-74 S QueT transporter
COPIEHFA_01471 1.9e-55 L Transposase
COPIEHFA_01472 5.7e-186 yegS 2.7.1.107 I Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
COPIEHFA_01473 0.0 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
COPIEHFA_01474 2.8e-85 ccl S cog cog4708
COPIEHFA_01475 8.3e-160 rbn E Belongs to the UPF0761 family
COPIEHFA_01476 5.5e-166 map 3.4.11.18 E Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed
COPIEHFA_01477 3.3e-231 ytoI K transcriptional regulator containing CBS domains
COPIEHFA_01478 1.8e-98 XK27_07830 2.3.1.128 J Acetyltransferase GNAT Family
COPIEHFA_01479 3.1e-234 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
COPIEHFA_01480 0.0 comEC S Competence protein ComEC
COPIEHFA_01481 2.2e-96 comEA L COG1555 DNA uptake protein and related DNA-binding proteins
COPIEHFA_01482 1.1e-56 plsC 2.3.1.51 I Acyltransferase
COPIEHFA_01483 6.1e-71 plsC 2.3.1.51 I Acyltransferase
COPIEHFA_01484 3.5e-78 nodB3 G polysaccharide deacetylase
COPIEHFA_01485 2.3e-47 nodB3 G polysaccharide deacetylase
COPIEHFA_01486 8.7e-139 yabB 2.1.1.223 L Methyltransferase
COPIEHFA_01487 1e-41 yazA L endonuclease containing a URI domain
COPIEHFA_01488 4.7e-249 L Transposase
COPIEHFA_01489 9.3e-239 L Transposase
COPIEHFA_01490 3.2e-252 cshA 3.6.4.13 JKL DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
COPIEHFA_01491 2.3e-154 corA P CorA-like protein
COPIEHFA_01492 1.9e-62 yjqA S Bacterial PH domain
COPIEHFA_01493 2.1e-97 thiT S Thiamine transporter
COPIEHFA_01494 4.1e-153 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
COPIEHFA_01495 3e-199 yjbB G Permeases of the major facilitator superfamily
COPIEHFA_01496 3.1e-300 prfC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
COPIEHFA_01497 3.8e-82 ywaF S Integral membrane protein (intg_mem_TP0381)
COPIEHFA_01498 3e-259 murF 6.3.2.10 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
COPIEHFA_01502 1.1e-155 cjaA ET ABC transporter substrate-binding protein
COPIEHFA_01503 1.7e-134 glnQ 3.6.3.21 E abc transporter atp-binding protein
COPIEHFA_01504 3e-106 P ABC transporter (Permease
COPIEHFA_01505 6e-115 papP P ABC transporter (Permease
COPIEHFA_01506 1.7e-193 ddl 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
COPIEHFA_01507 4.7e-31 copZ 2.7.7.77 P Heavy metal-associated domain protein
COPIEHFA_01508 0.0 copA 3.6.3.54 P P-type ATPase
COPIEHFA_01509 2.7e-73 copY K Copper transport repressor, CopY TcrY family
COPIEHFA_01510 2.1e-143 trpA 4.2.1.20 E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
COPIEHFA_01511 1.1e-228 trpB 4.2.1.20, 5.3.1.24 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
COPIEHFA_01512 3.3e-98 trpF 4.1.1.48, 4.2.1.160, 4.2.1.20, 5.3.1.24 E belongs to the TrpF family
COPIEHFA_01513 2.5e-133 trpC 4.1.1.48, 5.3.1.24 E Belongs to the TrpC family
COPIEHFA_01514 7.8e-180 trpD 2.4.2.18, 4.1.3.27 F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
COPIEHFA_01515 8e-105 trpG 2.4.2.18, 2.6.1.85, 4.1.3.27 EH anthranilate
COPIEHFA_01516 2.8e-257 trpE 4.1.3.27 EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
COPIEHFA_01517 3.7e-42 pchB 2.5.1.19, 4.2.1.10, 4.2.99.21, 5.4.99.5 E Chorismate mutase
COPIEHFA_01518 3.2e-56
COPIEHFA_01519 0.0 ctpE P E1-E2 ATPase
COPIEHFA_01520 3.9e-26
COPIEHFA_01521 1.2e-43 yaaK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
COPIEHFA_01522 9.7e-28 L transposase activity
COPIEHFA_01523 2.7e-129 K transcriptional regulator, MerR family
COPIEHFA_01524 1.4e-104 dnaQ 2.7.7.7 L DNA polymerase III
COPIEHFA_01525 1.2e-41 WQ51_02910 S Protein of unknown function, DUF536
COPIEHFA_01526 7.4e-64 XK27_02560 S cog cog2151
COPIEHFA_01527 0.0 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
COPIEHFA_01528 7.7e-227 ytfP S Flavoprotein
COPIEHFA_01530 3.1e-121 trmB 2.1.1.297, 2.1.1.33 J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
COPIEHFA_01531 1.2e-151 ytmP 2.7.1.89 M Phosphotransferase
COPIEHFA_01532 3e-182 ecsB U ABC transporter
COPIEHFA_01533 2.3e-133 ecsA V abc transporter atp-binding protein
COPIEHFA_01534 4.3e-71 hit FG Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
COPIEHFA_01535 6.2e-11
COPIEHFA_01536 1.2e-55 S CD20-like family
COPIEHFA_01537 5.2e-105
COPIEHFA_01538 0.0 clpL O ATP-dependent Clp protease ATP-binding subunit
COPIEHFA_01539 6.9e-206 ylbM S Belongs to the UPF0348 family
COPIEHFA_01540 2e-140 yqeM Q Methyltransferase domain protein
COPIEHFA_01541 6e-58 rsfS J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
COPIEHFA_01542 1.4e-107 nadD 2.7.6.3, 2.7.7.18 H HD superfamily hydrolase involved in NAD metabolism
COPIEHFA_01543 3.1e-118 nadD 2.7.7.18, 3.6.1.55 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
COPIEHFA_01544 3.5e-49 yhbY J RNA-binding protein
COPIEHFA_01545 1.7e-215 yqeH S in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis
COPIEHFA_01546 5.1e-98 yqeG S hydrolase of the HAD superfamily
COPIEHFA_01547 4.1e-151 yicL EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
COPIEHFA_01548 9.3e-65
COPIEHFA_01549 7.8e-274 gatB 6.1.1.12, 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
COPIEHFA_01550 3.5e-269 gatA 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
COPIEHFA_01551 1.4e-47 gatC 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
COPIEHFA_01552 6.1e-29 M lipopolysaccharide 3-alpha-galactosyltransferase activity
COPIEHFA_01553 4.1e-242 ascB 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
COPIEHFA_01554 2.3e-95 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
COPIEHFA_01555 4.5e-152 hlpA M Belongs to the NlpA lipoprotein family
COPIEHFA_01556 6.8e-101 pncA Q isochorismatase
COPIEHFA_01557 1.2e-140 codY K DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
COPIEHFA_01558 6.2e-240 alaA 2.6.1.2, 2.6.1.66 E Aminotransferase
COPIEHFA_01559 2.4e-75 XK27_03180 T universal stress protein
COPIEHFA_01562 2e-157 pflA 1.97.1.4 C Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
COPIEHFA_01563 2e-239 hlyX S COG1253 Hemolysins and related proteins containing CBS domains
COPIEHFA_01564 1.2e-143 modF 3.6.3.21, 3.6.3.34 P abc transporter atp-binding protein
COPIEHFA_01565 0.0 yjcE P NhaP-type Na H and K H antiporters
COPIEHFA_01567 1.4e-98 ytqB 2.1.1.176 J (SAM)-dependent
COPIEHFA_01568 1.3e-184 yhcC S radical SAM protein
COPIEHFA_01569 2.2e-196 ylbL T Belongs to the peptidase S16 family
COPIEHFA_01570 1.3e-87 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
COPIEHFA_01571 1.9e-92 rsmD 2.1.1.171 L Methyltransferase
COPIEHFA_01572 5.5e-172 trxB 1.8.1.9 C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
COPIEHFA_01573 1.1e-09 S Protein of unknown function (DUF4059)
COPIEHFA_01574 1.1e-130 tcyN 3.6.3.21 E abc transporter atp-binding protein
COPIEHFA_01575 3e-162 yxeN P ABC transporter (Permease
COPIEHFA_01576 8.3e-151 yxeM ET ABC-type amino acid transport signal transduction systems, periplasmic component domain
COPIEHFA_01578 3.1e-206 dinB 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
COPIEHFA_01579 0.0 pflB 2.3.1.54 C formate acetyltransferase'
COPIEHFA_01580 1.8e-147 cah 4.2.1.1 P carbonic anhydrase
COPIEHFA_01581 7.8e-85 yjcF S COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
COPIEHFA_01582 1e-44 hsdS_1 3.1.21.3 V type I restriction modification DNA specificity domain
COPIEHFA_01583 1.2e-85 D nuclear chromosome segregation
COPIEHFA_01584 1.5e-127 ybbM S transport system, permease component
COPIEHFA_01585 1.2e-117 ybbL S abc transporter atp-binding protein
COPIEHFA_01586 4.5e-185 ampC V COG1680 Beta-lactamase class C and other penicillin binding proteins
COPIEHFA_01587 4.6e-140 cppA E CppA N-terminal
COPIEHFA_01588 5e-44 V CAAX protease self-immunity
COPIEHFA_01589 2.3e-164 gla U Belongs to the MIP aquaporin (TC 1.A.8) family
COPIEHFA_01590 0.0 pepX 3.4.14.11 E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline
COPIEHFA_01593 3e-47 spiA K sequence-specific DNA binding
COPIEHFA_01594 2.9e-28 blpT
COPIEHFA_01595 6.7e-98 blpT
COPIEHFA_01596 5.1e-122 L Transposase
COPIEHFA_01597 1.2e-165 L integrase core domain
COPIEHFA_01602 4.3e-25 S Bacteriocin class II with double-glycine leader peptide
COPIEHFA_01605 7.4e-135 agrA KT phosphorelay signal transduction system
COPIEHFA_01606 9.9e-239 blpH 2.7.13.3 T protein histidine kinase activity
COPIEHFA_01608 7.3e-237 mesE M Transport protein ComB
COPIEHFA_01609 0.0 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
COPIEHFA_01610 0.0 mdlB V abc transporter atp-binding protein
COPIEHFA_01611 0.0 mdlA V abc transporter atp-binding protein
COPIEHFA_01613 5e-93 XK27_09885 V Glycopeptide antibiotics resistance protein
COPIEHFA_01614 3e-223 rlmN 2.1.1.192 J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
COPIEHFA_01615 2.4e-66 yutD J protein conserved in bacteria
COPIEHFA_01616 1.3e-270 yunD 3.1.3.5 F Belongs to the 5'-nucleotidase family
COPIEHFA_01618 1.4e-221 cshB 3.6.4.13 JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
COPIEHFA_01619 6.3e-185 mraY 2.7.8.13 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
COPIEHFA_01620 0.0 ftsI 3.4.16.4 M penicillin-binding protein
COPIEHFA_01621 8.1e-46 ftsL D cell division protein FtsL
COPIEHFA_01622 3.9e-173 rsmH 2.1.1.199 J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
COPIEHFA_01623 3e-128
COPIEHFA_01624 9.7e-32 yhaI J Protein of unknown function (DUF805)
COPIEHFA_01625 1.1e-12 D nuclear chromosome segregation
COPIEHFA_01626 2e-225 proA 1.2.1.41 E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
COPIEHFA_01627 5.7e-141 proB 2.7.2.11 E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
COPIEHFA_01628 2.2e-285 XK27_00765
COPIEHFA_01629 8.1e-134 ecsA_2 V abc transporter atp-binding protein
COPIEHFA_01630 5.2e-125 S Protein of unknown function (DUF554)
COPIEHFA_01631 0.0 addA 3.6.4.12 L ATP-dependent helicase nuclease subunit A
COPIEHFA_01632 0.0 rexB 3.1.21.3, 3.6.4.12 L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
COPIEHFA_01633 9.8e-57 liaI S membrane
COPIEHFA_01634 7e-10 XK27_02470 K LytTr DNA-binding domain protein
COPIEHFA_01635 1.8e-65 KT response to antibiotic
COPIEHFA_01636 5.2e-81 yebC M Membrane
COPIEHFA_01637 2.9e-18 yebC M Membrane
COPIEHFA_01638 4.3e-261 XK27_03190 5.2.1.8 S hydrolases of the HAD superfamily
COPIEHFA_01639 8.5e-173 ansA 3.5.1.1 EJ COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D
COPIEHFA_01640 0.0 recG 3.6.4.12 L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
COPIEHFA_01641 1.9e-182 alr 5.1.1.1, 5.1.1.5 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
COPIEHFA_01642 4.5e-61 acpS 2.7.6.3, 2.7.8.7, 5.1.1.1 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
COPIEHFA_01643 1.1e-197 aroF 2.5.1.54 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
COPIEHFA_01644 2.9e-198 aroF 2.5.1.54 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
COPIEHFA_01645 0.0 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
COPIEHFA_01647 3e-189 manA 5.3.1.8 G mannose-6-phosphate isomerase
COPIEHFA_01648 4.1e-172 scrK 2.7.1.2, 2.7.1.4 GK Fructokinase
COPIEHFA_01649 0.0 scrA 2.7.1.208, 2.7.1.211 G pts system
COPIEHFA_01650 5.4e-291 scrB 3.2.1.26 GH32 G invertase
COPIEHFA_01651 8.3e-179 scrR K Transcriptional
COPIEHFA_01652 2.1e-73 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
COPIEHFA_01653 3.4e-62 yqhY S protein conserved in bacteria
COPIEHFA_01654 1.2e-97 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
COPIEHFA_01655 3.7e-84 comEB 3.5.4.12 F ComE operon protein 2
COPIEHFA_01656 3.1e-136 pepP 3.4.11.9, 3.4.13.9 E Belongs to the peptidase M24B family
COPIEHFA_01657 2.1e-12 pepP 3.4.11.9, 3.4.13.9 E Belongs to the peptidase M24B family
COPIEHFA_01659 8e-44 V 'abc transporter, ATP-binding protein
COPIEHFA_01660 1e-58 V 'abc transporter, ATP-binding protein
COPIEHFA_01663 0.0 uvrA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
COPIEHFA_01664 2e-169 corA P COG0598 Mg2 and Co2 transporters
COPIEHFA_01665 3.1e-124 XK27_01040 S Pfam PF06570
COPIEHFA_01667 9.7e-36 rpsR J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
COPIEHFA_01668 2.7e-91 ssb L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
COPIEHFA_01669 3.9e-47 rpsF J Binds together with S18 to 16S ribosomal RNA
COPIEHFA_01670 3.6e-41 XK27_05745
COPIEHFA_01671 2.5e-230 mutY L A G-specific adenine glycosylase
COPIEHFA_01676 0.0 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
COPIEHFA_01677 0.0 mutS2 L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
COPIEHFA_01678 4.3e-92 cvpA S toxin biosynthetic process
COPIEHFA_01679 2.3e-13 zapA D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
COPIEHFA_01680 1.8e-159 rnhC 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
COPIEHFA_01681 1.3e-113 lepB 3.4.21.89 U Belongs to the peptidase S26 family
COPIEHFA_01682 0.0 recD2 3.1.11.5 L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
COPIEHFA_01683 2e-47 azlD E branched-chain amino acid
COPIEHFA_01684 1.2e-113 azlC E AzlC protein
COPIEHFA_01685 1.9e-186 tsaD 2.3.1.234 O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
COPIEHFA_01686 1.3e-73 rimI 2.3.1.128 K This enzyme acetylates the N-terminal alanine of ribosomal protein S18
COPIEHFA_01687 5.6e-121 yeaZ 2.3.1.234 O COG1214, inactive homolog of metal-dependent proteases
COPIEHFA_01688 2.5e-33 ykzG S Belongs to the UPF0356 family
COPIEHFA_01689 0.0 rnjA S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
COPIEHFA_01690 2.7e-40 pscB M CHAP domain protein
COPIEHFA_01691 1.5e-263 glnA 6.3.1.2 E glutamine synthetase
COPIEHFA_01692 8.5e-63 glnR K Transcriptional regulator
COPIEHFA_01693 5.4e-40 S Fusaric acid resistance protein-like
COPIEHFA_01694 3e-13
COPIEHFA_01695 8.9e-30
COPIEHFA_01696 2e-222 pgk 2.7.2.3, 5.3.1.1 F Belongs to the phosphoglycerate kinase family
COPIEHFA_01697 3.2e-42 L Transposase
COPIEHFA_01698 1.9e-46 L transposase activity
COPIEHFA_01699 7.4e-23 L Transposase
COPIEHFA_01700 1.8e-56 L transposition
COPIEHFA_01701 9.1e-83 L Integrase core domain protein
COPIEHFA_01702 1e-102 L Transposase
COPIEHFA_01703 1.1e-110 L Transposase
COPIEHFA_01704 1.4e-189 gap 1.2.1.12 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
COPIEHFA_01705 0.0 fusA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
COPIEHFA_01706 6.7e-81 rpsG J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
COPIEHFA_01707 2.3e-69 rpsL J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
COPIEHFA_01708 1.1e-142 purR 2.4.2.7 F operon repressor
COPIEHFA_01709 4e-178 cbf S 3'-5' exoribonuclease yhaM
COPIEHFA_01710 6.9e-173 rmuC S RmuC domain protein
COPIEHFA_01711 3.1e-118 thiN 2.7.6.2 H thiamine pyrophosphokinase
COPIEHFA_01712 3e-119 rpe 5.1.3.1 G Belongs to the ribulose-phosphate 3-epimerase family
COPIEHFA_01713 2.6e-163 rsgA 3.1.3.100 G One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
COPIEHFA_01715 1.1e-156 ksgA 2.1.1.182 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
COPIEHFA_01716 8.4e-99 rnmV 3.1.26.8 J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
COPIEHFA_01717 4.1e-144 tatD L Hydrolase, tatd
COPIEHFA_01718 2.5e-74 yccU S CoA-binding protein
COPIEHFA_01719 4.8e-51 trxA O Belongs to the thioredoxin family
COPIEHFA_01720 7.8e-143 S Macro domain protein
COPIEHFA_01721 3.1e-10 L thioesterase
COPIEHFA_01722 2.2e-54 bta 1.8.1.8 CO cell redox homeostasis
COPIEHFA_01726 1.7e-226 tgt 2.4.2.29 F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
COPIEHFA_01727 1.6e-87 L Transposase
COPIEHFA_01728 1e-13 rpmH J Ribosomal protein L34
COPIEHFA_01729 1.6e-249 L Transposase
COPIEHFA_01730 3.4e-186 jag S RNA-binding protein
COPIEHFA_01731 7.5e-141 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
COPIEHFA_01732 1.2e-55 rnpA 3.1.26.5 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
COPIEHFA_01733 1.9e-264 argH 4.3.2.1 E Argininosuccinate lyase
COPIEHFA_01734 4.4e-230 argG 6.3.4.5 E Belongs to the argininosuccinate synthase family. Type 1 subfamily
COPIEHFA_01735 6e-282 gltX 6.1.1.17, 6.1.1.24 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
COPIEHFA_01736 2e-20 amiA E ABC transporter, substrate-binding protein, family 5
COPIEHFA_01737 6.6e-63 amiA E transmembrane transport
COPIEHFA_01738 4.2e-74 amiA E transmembrane transport
COPIEHFA_01739 4.8e-120 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
COPIEHFA_01740 3.7e-70 rplK J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
COPIEHFA_01741 9.2e-51 S Protein of unknown function (DUF3397)
COPIEHFA_01742 2e-88 cah 4.2.1.1 P Reversible hydration of carbon dioxide
COPIEHFA_01743 7.3e-59 WQ51_05710 S Mitochondrial biogenesis AIM24
COPIEHFA_01744 6.2e-12 WQ51_05710 S Mitochondrial biogenesis AIM24
COPIEHFA_01745 4.3e-98 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
COPIEHFA_01746 4.8e-103 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
COPIEHFA_01747 1.1e-80 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
COPIEHFA_01748 1.8e-19 XK27_09620 S FMN reductase (NADPH) activity
COPIEHFA_01749 4.3e-77 XK27_09620 S reductase
COPIEHFA_01750 2.1e-32 XK27_09615 S FMN reductase (NADPH) activity
COPIEHFA_01751 1.2e-131 XK27_09615 S PAS domain
COPIEHFA_01752 1.9e-07 fnt P Formate nitrite transporter
COPIEHFA_01753 6.4e-54 fnt P Formate nitrite transporter
COPIEHFA_01754 7.2e-64 XK27_08585 S Psort location CytoplasmicMembrane, score
COPIEHFA_01755 2.8e-185 gpsA 1.1.1.94 I Glycerol-3-phosphate dehydrogenase
COPIEHFA_01756 1.8e-170 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
COPIEHFA_01757 1.2e-165 L integrase core domain
COPIEHFA_01758 1.1e-121 L Transposase
COPIEHFA_01759 2.8e-117 gluP 3.4.21.105 O membrane protein (homolog of Drosophila rhomboid)
COPIEHFA_01760 9.1e-95 ygfA 6.3.3.2 H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
COPIEHFA_01761 3e-220 hipO 3.5.1.47 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
COPIEHFA_01762 8.1e-59 dapD 2.3.1.117, 2.3.1.89 E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
COPIEHFA_01763 1.1e-20 S glycolate biosynthetic process
COPIEHFA_01764 1.5e-64 S phosphatase activity
COPIEHFA_01765 2e-157 rrmA 2.1.1.187 Q methyltransferase
COPIEHFA_01768 7.8e-88 tadA 3.5.4.1, 3.5.4.33 FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
COPIEHFA_01769 1.9e-65 ssb_2 L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
COPIEHFA_01770 4.1e-36 yeeD O sulfur carrier activity
COPIEHFA_01771 2.1e-188 yeeE S Sulphur transport
COPIEHFA_01772 7.9e-114 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
COPIEHFA_01773 2.1e-54 ytpP 2.7.1.180, 5.3.4.1 CO Thioredoxin
COPIEHFA_01774 1.8e-09 S Domain of unknown function (DUF4651)
COPIEHFA_01775 4.7e-169 pepA 3.4.11.7 G COG1363 Cellulase M and related proteins
COPIEHFA_01776 1.1e-130 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
COPIEHFA_01777 3.9e-111 S CAAX amino terminal protease family protein
COPIEHFA_01779 2.5e-66 V CAAX protease self-immunity
COPIEHFA_01780 8.8e-27 lanR K sequence-specific DNA binding
COPIEHFA_01781 2.9e-221 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
COPIEHFA_01782 5.9e-177 ytxK 2.1.1.72 L DNA methylase
COPIEHFA_01783 6.8e-13 comGF U Putative Competence protein ComGF
COPIEHFA_01784 4e-72 comGF U Competence protein ComGF
COPIEHFA_01785 1.4e-15 NU Type II secretory pathway pseudopilin
COPIEHFA_01786 1.8e-57 cglD NU Competence protein
COPIEHFA_01787 9.4e-42 comGC U Required for transformation and DNA binding
COPIEHFA_01788 9.2e-153 cglB NU type II secretion system
COPIEHFA_01789 4.2e-175 comGA NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
COPIEHFA_01790 2.9e-68 S cog cog4699
COPIEHFA_01791 0.0 rpoC 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
COPIEHFA_01792 0.0 rpoB 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
COPIEHFA_01793 0.0 pbp1B 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
COPIEHFA_01794 1.2e-238 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
COPIEHFA_01795 9.3e-239 L Transposase
COPIEHFA_01796 1.6e-196 ilvC 1.1.1.86 H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
COPIEHFA_01797 7.7e-77 ilvN 2.2.1.6 E Acetolactate synthase
COPIEHFA_01798 0.0 ilvB 2.2.1.6 EH Acetolactate synthase
COPIEHFA_01799 8.8e-281 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
COPIEHFA_01800 8.4e-09 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
COPIEHFA_01801 1.7e-304 yloV S kinase related to dihydroxyacetone kinase
COPIEHFA_01802 1.8e-57 asp S cog cog1302
COPIEHFA_01803 6e-225 norN V Mate efflux family protein
COPIEHFA_01804 6.4e-279 thrC 4.2.3.1 E Threonine synthase
COPIEHFA_01805 3.2e-65 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
COPIEHFA_01806 2.7e-35 adhE 1.1.1.1, 1.2.1.10 C hydroxyacid-oxoacid transhydrogenase activity
COPIEHFA_01807 3.5e-76 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
COPIEHFA_01808 1.3e-135 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
COPIEHFA_01809 1.4e-63 adhE 1.1.1.1, 1.2.1.10 C Dehydrogenase
COPIEHFA_01810 0.0 pepO 3.4.24.71 O Peptidase family M13
COPIEHFA_01811 2.8e-38 treC 3.2.1.93 GH13 G COG0366 Glycosidases
COPIEHFA_01812 1.2e-69 treC 3.2.1.93 GH13 G COG0366 Glycosidases
COPIEHFA_01813 5.9e-66 treC 3.2.1.93 GH13 G COG0366 Glycosidases
COPIEHFA_01814 1.4e-54 treB 2.7.1.201 G PTS System
COPIEHFA_01815 5.8e-21 treR K DNA-binding transcription factor activity
COPIEHFA_01816 1.2e-85 treR K trehalose operon
COPIEHFA_01817 3.3e-95 ywlG S Belongs to the UPF0340 family
COPIEHFA_01820 3.3e-09 L PFAM Integrase, catalytic core
COPIEHFA_01821 6.7e-114 L PFAM Integrase, catalytic core
COPIEHFA_01822 5.1e-47 K Putative DNA-binding domain
COPIEHFA_01823 2.5e-13 2.3.1.82 M Acetyltransferase GNAT Family
COPIEHFA_01824 3.9e-125 gltT C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
COPIEHFA_01825 7.1e-135 HJ the current gene model (or a revised gene model) may contain a frame shift
COPIEHFA_01830 2e-39
COPIEHFA_01831 9e-164 fba 4.1.2.13, 4.1.2.29 G aldolase
COPIEHFA_01833 3.9e-110 6.3.2.2 H ergothioneine biosynthetic process
COPIEHFA_01834 2.7e-19 6.3.2.2 H gamma-glutamylcysteine synthetase
COPIEHFA_01835 2.5e-12 6.3.2.2 H gamma-glutamylcysteine synthetase
COPIEHFA_01836 3.3e-09 L PFAM Integrase, catalytic core
COPIEHFA_01837 1.8e-111 L PFAM Integrase, catalytic core
COPIEHFA_01838 3.3e-62 rplQ J ribosomal protein l17
COPIEHFA_01839 4.8e-171 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
COPIEHFA_01840 9.6e-62 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
COPIEHFA_01841 4e-57 rpsM J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
COPIEHFA_01842 6e-15 rpmJ J Belongs to the bacterial ribosomal protein bL36 family
COPIEHFA_01843 2.7e-32 infA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
COPIEHFA_01844 9.2e-121 adk 2.7.4.3 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
COPIEHFA_01845 1.3e-230 secY U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
COPIEHFA_01846 4.4e-58 rplO J binds to the 23S rRNA
COPIEHFA_01847 2.5e-23 rpmD J ribosomal protein l30
COPIEHFA_01848 1.7e-79 rpsE J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
COPIEHFA_01849 1.9e-56 rplR J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
COPIEHFA_01850 2.3e-93 rplF J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
COPIEHFA_01851 1.2e-67 rpsH J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
COPIEHFA_01852 1.5e-28 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
COPIEHFA_01853 1.6e-94 rplE J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
COPIEHFA_01854 1.4e-47 rplX J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
COPIEHFA_01855 1.1e-59 rplN J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
COPIEHFA_01856 6e-39 rpsQ J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
COPIEHFA_01857 2.7e-26 rpmC J Belongs to the universal ribosomal protein uL29 family
COPIEHFA_01858 7.2e-71 rplP J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
COPIEHFA_01859 2.1e-117 rpsC J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
COPIEHFA_01860 7.3e-53 rplV J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
COPIEHFA_01861 4.9e-47 rpsS J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
COPIEHFA_01862 8.8e-153 rplB J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
COPIEHFA_01863 2.4e-44 rplW J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
COPIEHFA_01864 5.7e-104 rplD J Forms part of the polypeptide exit tunnel
COPIEHFA_01865 1.1e-110 rplC J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
COPIEHFA_01866 1.3e-48 rpsJ J Involved in the binding of tRNA to the ribosomes
COPIEHFA_01867 7.8e-188 ruvB 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
COPIEHFA_01868 0.0 XK27_09800 I Acyltransferase
COPIEHFA_01869 1.7e-35 XK27_09805 S MORN repeat protein
COPIEHFA_01870 1.2e-79 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
COPIEHFA_01871 4.1e-250 purA 6.3.4.4 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
COPIEHFA_01872 8.8e-83 adk 2.7.4.3 F topology modulation protein
COPIEHFA_01873 1.6e-12 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
COPIEHFA_01874 1.3e-128 Z012_04635 K sequence-specific DNA binding
COPIEHFA_01876 3.6e-232 C Radical SAM
COPIEHFA_01877 5.1e-287 V ABC transporter transmembrane region
COPIEHFA_01878 2.5e-89 K sequence-specific DNA binding
COPIEHFA_01879 2.2e-132 int L Belongs to the 'phage' integrase family
COPIEHFA_01881 5.2e-237 rarA L ATPase related to the helicase subunit of the Holliday junction resolvase
COPIEHFA_01882 5.5e-26 rpmB J Belongs to the bacterial ribosomal protein bL28 family
COPIEHFA_01883 2.2e-44 yrzL S Belongs to the UPF0297 family
COPIEHFA_01884 1.2e-70 yqgF L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
COPIEHFA_01885 4.2e-44 yrzB S Belongs to the UPF0473 family
COPIEHFA_01886 6.2e-299 ccs S the current gene model (or a revised gene model) may contain a frame shift
COPIEHFA_01887 0.0 nrdD 1.1.98.6 F Ribonucleoside-triphosphate reductase
COPIEHFA_01888 7.5e-14
COPIEHFA_01889 2.6e-91 XK27_10930 K acetyltransferase
COPIEHFA_01890 3.7e-116 nrdG 1.97.1.4 O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
COPIEHFA_01891 1.8e-147 yaaA S Belongs to the UPF0246 family
COPIEHFA_01892 9.3e-167 XK27_01785 S cog cog1284
COPIEHFA_01893 0.0 aspS 6.1.1.12 J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
COPIEHFA_01895 1.6e-241 hisS 6.1.1.21 J histidyl-tRNA synthetase
COPIEHFA_01896 1.4e-53 metE 2.1.1.14 E Methionine synthase
COPIEHFA_01897 5.2e-55 metE 2.1.1.14 E Methionine synthase
COPIEHFA_01898 1.4e-36 metE 2.1.1.14 E Methionine synthase
COPIEHFA_01899 1e-24 rpmF J Belongs to the bacterial ribosomal protein bL32 family
COPIEHFA_01900 6.7e-19 rpmG J Belongs to the bacterial ribosomal protein bL33 family
COPIEHFA_01903 2.6e-49 yegS 2.7.1.107 I lipid kinase activity
COPIEHFA_01904 2.5e-96 S Hydrophobic domain protein
COPIEHFA_01906 1e-29 S Membrane
COPIEHFA_01907 9.1e-101
COPIEHFA_01908 1.8e-23 S Small integral membrane protein
COPIEHFA_01909 3.1e-85 M Protein conserved in bacteria
COPIEHFA_01910 1.1e-11 K CsbD-like
COPIEHFA_01911 3.4e-13 nudL L hydrolase
COPIEHFA_01912 4e-19 K negative regulation of transcription, DNA-templated
COPIEHFA_01913 1.7e-23 K negative regulation of transcription, DNA-templated
COPIEHFA_01915 1.8e-19 XK27_06920 S Protein of unknown function (DUF1700)
COPIEHFA_01916 1.8e-88 S Putative adhesin
COPIEHFA_01917 3.9e-161 XK27_06930 V domain protein
COPIEHFA_01918 6.4e-96 XK27_06935 K transcriptional regulator
COPIEHFA_01919 4.8e-55 ypaA M Membrane
COPIEHFA_01920 2.7e-08
COPIEHFA_01921 9.8e-109 rpsD J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
COPIEHFA_01922 8.2e-48 veg S Biofilm formation stimulator VEG
COPIEHFA_01923 1.5e-245 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
COPIEHFA_01924 1.5e-69 rplI J binds to the 23S rRNA
COPIEHFA_01925 9.6e-89 yybT T signaling protein consisting of a modified GGDEF domain and a DHH domain
COPIEHFA_01926 1.3e-265 yybT T signaling protein consisting of a modified GGDEF domain and a DHH domain
COPIEHFA_01927 0.0 gidA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
COPIEHFA_01928 1.5e-77 F NUDIX domain
COPIEHFA_01929 8.6e-220 mnmA 2.8.1.13 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
COPIEHFA_01930 0.0 S Bacterial membrane protein, YfhO
COPIEHFA_01931 1.5e-88 isaA GH23 M Immunodominant staphylococcal antigen A
COPIEHFA_01932 1.5e-84 lytE M LysM domain protein
COPIEHFA_01933 2e-138 ecfT P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
COPIEHFA_01934 5.2e-153 ecfA2 3.6.3.55 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
COPIEHFA_01935 1.5e-152 ecfA1 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
COPIEHFA_01936 3.1e-90 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
COPIEHFA_01937 1.1e-137 ymfM S sequence-specific DNA binding
COPIEHFA_01938 3.1e-242 ymfH S Peptidase M16
COPIEHFA_01939 4.8e-235 ymfF S Peptidase M16
COPIEHFA_01940 1.6e-45 yaaA S S4 domain protein YaaA
COPIEHFA_01941 5.9e-205 recF L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
COPIEHFA_01942 4.3e-275 guaB 1.1.1.205 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
COPIEHFA_01943 6.3e-193 trpS 6.1.1.2 J Tryptophanyl-tRNA synthetase
COPIEHFA_01944 4.2e-153 yvjA S membrane
COPIEHFA_01945 9.8e-250 ybiT S abc transporter atp-binding protein
COPIEHFA_01946 2.5e-43 ybiT S abc transporter atp-binding protein
COPIEHFA_01947 0.0 XK27_10405 S Bacterial membrane protein YfhO
COPIEHFA_01951 6.2e-120 yoaK S Psort location CytoplasmicMembrane, score
COPIEHFA_01952 1.1e-86 rlmH 2.1.1.177 J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
COPIEHFA_01953 2.6e-193 htrA 3.4.21.107 O Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain'
COPIEHFA_01954 8.5e-134 parB K Belongs to the ParB family

eggNOG-mapper v2 (Database: eggNOG v5.0, Jul. 2018 release)