ORF_ID e_value Gene_name EC_number CAZy COGs Description
HOLAGCBD_00002 1.2e-79 S Psort location Cytoplasmic, score
HOLAGCBD_00003 5.8e-40
HOLAGCBD_00004 9.9e-22 NT phage tail tape measure protein
HOLAGCBD_00005 6.4e-38 NT phage tail tape measure protein
HOLAGCBD_00007 6.5e-27
HOLAGCBD_00008 2.1e-55
HOLAGCBD_00009 1.7e-27
HOLAGCBD_00010 3.4e-27
HOLAGCBD_00011 1.1e-30
HOLAGCBD_00012 8.7e-21
HOLAGCBD_00013 1.9e-95 xkdG S Phage capsid family
HOLAGCBD_00014 7.1e-32 xkdG S Phage capsid family
HOLAGCBD_00015 2.1e-69 S Phage portal protein
HOLAGCBD_00016 4.5e-222 S Terminase
HOLAGCBD_00017 4.8e-10
HOLAGCBD_00019 8.6e-40 L HNH nucleases
HOLAGCBD_00023 2.8e-92
HOLAGCBD_00025 6.5e-12
HOLAGCBD_00029 2e-46
HOLAGCBD_00031 2.5e-27
HOLAGCBD_00032 4.8e-11
HOLAGCBD_00033 3.8e-20
HOLAGCBD_00034 1e-60 L HNH endonuclease
HOLAGCBD_00035 5.3e-66
HOLAGCBD_00037 1.6e-84 recT L RecT family
HOLAGCBD_00038 1.7e-110 yqaJ L YqaJ-like viral recombinase domain
HOLAGCBD_00042 4.4e-41 O prohibitin homologues
HOLAGCBD_00044 5.7e-82 K BRO family, N-terminal domain
HOLAGCBD_00048 1.5e-24
HOLAGCBD_00049 2e-38
HOLAGCBD_00051 5.5e-151 XK27_00240 K Fic/DOC family
HOLAGCBD_00052 3.2e-117 L Phage integrase family
HOLAGCBD_00053 5.1e-158 G Fructosamine kinase
HOLAGCBD_00054 2e-155 uppP 3.6.1.27 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
HOLAGCBD_00055 1.6e-156 S PAC2 family
HOLAGCBD_00060 9.4e-36
HOLAGCBD_00061 4.7e-76 garA T Inner membrane component of T3SS, cytoplasmic domain
HOLAGCBD_00062 9.7e-112 K helix_turn_helix, mercury resistance
HOLAGCBD_00063 6e-61
HOLAGCBD_00064 3e-141 pgp 3.1.3.18 S HAD-hyrolase-like
HOLAGCBD_00065 3.9e-62 rbpA K Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters
HOLAGCBD_00066 0.0 helY L DEAD DEAH box helicase
HOLAGCBD_00067 2.1e-54
HOLAGCBD_00068 0.0 pafB K WYL domain
HOLAGCBD_00069 1.4e-264 ugpA 2.7.7.9 G UTP-glucose-1-phosphate uridylyltransferase
HOLAGCBD_00071 1.1e-69
HOLAGCBD_00072 0.0 der 1.1.1.399, 1.1.1.95, 2.7.4.25 F GTPase that plays an essential role in the late steps of ribosome biogenesis
HOLAGCBD_00073 9.1e-144 rluB 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
HOLAGCBD_00074 1.5e-161 glpF U Belongs to the MIP aquaporin (TC 1.A.8) family
HOLAGCBD_00075 8.2e-34
HOLAGCBD_00076 0.0 purH 2.1.2.3, 3.5.4.10 F Bifunctional purine biosynthesis protein PurH
HOLAGCBD_00077 1.8e-246
HOLAGCBD_00078 2.6e-161 sucD 6.2.1.5 C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HOLAGCBD_00079 2.2e-221 sucC 6.2.1.5 F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
HOLAGCBD_00080 1.8e-99 apt 2.4.2.22, 2.4.2.7 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HOLAGCBD_00081 1.8e-50 yajC U Preprotein translocase subunit
HOLAGCBD_00082 5.6e-200 ruvB 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
HOLAGCBD_00083 1e-105 ruvA 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
HOLAGCBD_00084 1.8e-99 ruvC 3.1.22.4 L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HOLAGCBD_00085 5.2e-128 yebC K transcriptional regulatory protein
HOLAGCBD_00086 3.5e-112 pgsA1 2.7.8.11, 2.7.8.5 I CDP-alcohol phosphatidyltransferase
HOLAGCBD_00087 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HOLAGCBD_00088 1.6e-141 S Bacterial protein of unknown function (DUF881)
HOLAGCBD_00089 4.2e-45 sbp S Protein of unknown function (DUF1290)
HOLAGCBD_00090 9.9e-172 S Bacterial protein of unknown function (DUF881)
HOLAGCBD_00091 1e-102 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HOLAGCBD_00092 1.9e-155 hisG 2.4.2.17 F ATP phosphoribosyltransferase
HOLAGCBD_00093 1.9e-40 hisE 3.5.4.19, 3.6.1.31, 5.3.1.16 E Phosphoribosyl-ATP pyrophosphohydrolase
HOLAGCBD_00094 4.2e-97 rpe 5.1.3.1 G Ribulose-phosphate 3-epimerase
HOLAGCBD_00095 4.6e-180 lgt 2.1.1.199 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HOLAGCBD_00096 3.4e-155 trpA 4.2.1.20 E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
HOLAGCBD_00097 0.0 trpB 4.1.1.48, 4.2.1.20 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HOLAGCBD_00098 2.7e-296 trpE 4.1.3.27 E Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HOLAGCBD_00099 2.9e-72 hisI 3.5.4.19, 3.6.1.31 E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HOLAGCBD_00100 3e-139 hisF 4.1.3.27 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
HOLAGCBD_00101 3.6e-224 rlmN 2.1.1.192 J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HOLAGCBD_00102 6.1e-177 cdsA 2.7.7.41, 2.7.7.67 I Cytidylyltransferase family
HOLAGCBD_00103 5.8e-92 frr J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
HOLAGCBD_00104 2.6e-135 pyrH 2.7.4.22 F Catalyzes the reversible phosphorylation of UMP to UDP
HOLAGCBD_00106 5e-143 tsf J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HOLAGCBD_00107 1.9e-139 rpsB J Belongs to the universal ribosomal protein uS2 family
HOLAGCBD_00108 1.1e-83 def 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
HOLAGCBD_00109 0.0 fadD3 6.2.1.3 I long-chain-fatty acid CoA ligase
HOLAGCBD_00110 5.4e-121
HOLAGCBD_00112 5e-190 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HOLAGCBD_00113 1.8e-141 nadD 2.7.7.18, 3.6.1.55 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HOLAGCBD_00114 3.2e-101
HOLAGCBD_00115 2.9e-243 proA 1.2.1.41 E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HOLAGCBD_00116 6.5e-251 glyA 2.1.2.1 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HOLAGCBD_00117 2.3e-284 thrC 4.2.3.1 E Threonine synthase N terminus
HOLAGCBD_00118 1e-232 EGP Major facilitator Superfamily
HOLAGCBD_00119 1.8e-104 3.1.3.27 E haloacid dehalogenase-like hydrolase
HOLAGCBD_00120 7.4e-174 G Fic/DOC family
HOLAGCBD_00121 2e-142
HOLAGCBD_00122 9.1e-164 IQ Enoyl-(Acyl carrier protein) reductase
HOLAGCBD_00123 4.5e-166 S Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HOLAGCBD_00124 7.4e-77 3.4.13.22 S Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HOLAGCBD_00125 1.1e-95 bcp 1.11.1.15 O Redoxin
HOLAGCBD_00126 9.2e-29 S Psort location Cytoplasmic, score 8.87
HOLAGCBD_00127 1.6e-94 S Pyridoxamine 5'-phosphate oxidase
HOLAGCBD_00128 0.0 S Histidine phosphatase superfamily (branch 2)
HOLAGCBD_00129 7.9e-44 L transposition
HOLAGCBD_00130 1.1e-23 C Acetamidase/Formamidase family
HOLAGCBD_00131 1.7e-58 K helix_turn_helix gluconate operon transcriptional repressor
HOLAGCBD_00132 2.3e-173 V ATPases associated with a variety of cellular activities
HOLAGCBD_00133 4.4e-116 S ABC-2 family transporter protein
HOLAGCBD_00134 1.7e-119 S Haloacid dehalogenase-like hydrolase
HOLAGCBD_00135 2.6e-260 recN L May be involved in recombinational repair of damaged DNA
HOLAGCBD_00136 2.4e-170 nadK 2.7.1.23 H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HOLAGCBD_00137 3.5e-261 trkB P Cation transport protein
HOLAGCBD_00138 3e-116 trkA P TrkA-N domain
HOLAGCBD_00139 2.9e-134 tlyA 2.1.1.226, 2.1.1.227 J Ribosomal RNA large subunit methyltransferase J
HOLAGCBD_00140 1.2e-191 yutF 3.1.3.41 G Haloacid dehalogenase-like hydrolase
HOLAGCBD_00141 1.3e-137 L Tetratricopeptide repeat
HOLAGCBD_00142 5e-251 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HOLAGCBD_00143 0.0 S Protein of unknown function (DUF975)
HOLAGCBD_00144 1.9e-136 S Putative ABC-transporter type IV
HOLAGCBD_00145 3e-87 6.1.1.14 S Metal dependent phosphohydrolases with conserved 'HD' motif.
HOLAGCBD_00146 2.9e-279 argH 4.3.2.1 E argininosuccinate lyase
HOLAGCBD_00147 4.6e-238 argG 6.3.4.5 E Belongs to the argininosuccinate synthase family. Type 1 subfamily
HOLAGCBD_00148 3.5e-83 argR K Regulates arginine biosynthesis genes
HOLAGCBD_00149 4.6e-185 argF 2.1.3.3 E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HOLAGCBD_00150 1e-240 argD 2.6.1.11, 2.6.1.17 E Aminotransferase class-III
HOLAGCBD_00151 2.8e-179 argB 2.7.2.8 E Belongs to the acetylglutamate kinase family. ArgB subfamily
HOLAGCBD_00152 6.7e-215 argJ 2.3.1.1, 2.3.1.35, 2.7.2.8 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HOLAGCBD_00153 1.9e-203 argC 1.2.1.38 E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HOLAGCBD_00154 1e-96
HOLAGCBD_00155 0.0 pheT 6.1.1.20 J Phenylalanyl-tRNA synthetase beta
HOLAGCBD_00156 5.9e-202 pheS 6.1.1.20 J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HOLAGCBD_00158 4.2e-95 yvdD 3.2.2.10 S Possible lysine decarboxylase
HOLAGCBD_00159 2.9e-17
HOLAGCBD_00161 1.5e-17 L HNH endonuclease
HOLAGCBD_00162 8.3e-113 ung2 3.2.2.27 L Uracil DNA glycosylase superfamily
HOLAGCBD_00163 2e-41 V DNA modification
HOLAGCBD_00164 2.3e-281 glnA 6.3.1.2 E glutamine synthetase
HOLAGCBD_00165 6e-143 S Domain of unknown function (DUF4191)
HOLAGCBD_00166 9.9e-248 lpdA 1.16.1.1, 1.8.1.4 C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HOLAGCBD_00167 4.4e-93 S Protein of unknown function (DUF3043)
HOLAGCBD_00168 4.2e-253 argE E Peptidase dimerisation domain
HOLAGCBD_00169 3.1e-145 cbiQ P Cobalt transport protein
HOLAGCBD_00170 2.3e-268 ykoD P ATPases associated with a variety of cellular activities
HOLAGCBD_00171 9.9e-85 ykoE S ABC-type cobalt transport system, permease component
HOLAGCBD_00172 7.4e-203 mrp D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP
HOLAGCBD_00173 0.0 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HOLAGCBD_00174 0.0 S Tetratricopeptide repeat
HOLAGCBD_00175 0.0 M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HOLAGCBD_00176 2.1e-307 2.8.2.22 S Arylsulfotransferase Ig-like domain
HOLAGCBD_00177 5e-145 bioM P ATPases associated with a variety of cellular activities
HOLAGCBD_00178 8.1e-221 E Aminotransferase class I and II
HOLAGCBD_00179 1.6e-140 ppgK 2.7.1.2, 2.7.1.63 GK ROK family
HOLAGCBD_00180 6.3e-201 S Glycosyltransferase, group 2 family protein
HOLAGCBD_00181 1.4e-144 tenA 3.5.99.2 K Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HOLAGCBD_00182 2.4e-47 yhbY J CRS1_YhbY
HOLAGCBD_00183 0.0 ecfA GP ABC transporter, ATP-binding protein
HOLAGCBD_00184 2e-107 ribU U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HOLAGCBD_00185 0.0 snf 2.7.11.1 KL Psort location Cytoplasmic, score 8.87
HOLAGCBD_00186 4.6e-107 kcsA U Ion channel
HOLAGCBD_00187 5e-187 ghrA EH D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
HOLAGCBD_00188 1.9e-83 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
HOLAGCBD_00189 1.7e-122 3.2.1.8 S alpha beta
HOLAGCBD_00191 5.1e-42 S Protein of unknown function DUF262
HOLAGCBD_00192 1e-12 S Protein of unknown function DUF262
HOLAGCBD_00193 2e-300 S Protein of unknown function DUF262
HOLAGCBD_00194 8.5e-252 S AAA-like domain
HOLAGCBD_00195 4.2e-56 S SIR2-like domain
HOLAGCBD_00196 1.1e-183 3.1.21.4 V Type III restriction enzyme res subunit
HOLAGCBD_00197 1.8e-56 L Eco57I restriction-modification methylase
HOLAGCBD_00198 1.9e-65 L Eco57I restriction-modification methylase
HOLAGCBD_00199 0.0 KL Type III restriction enzyme res subunit
HOLAGCBD_00200 2.6e-131 XK26_04895
HOLAGCBD_00201 1.6e-41 lexA 3.6.4.12 K Putative DNA-binding domain
HOLAGCBD_00202 2.2e-65 S Putative inner membrane protein (DUF1819)
HOLAGCBD_00203 3.2e-22
HOLAGCBD_00204 2.3e-70
HOLAGCBD_00205 2e-216
HOLAGCBD_00206 1e-147 S phosphoesterase or phosphohydrolase
HOLAGCBD_00207 2.4e-39 ghrA EH D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
HOLAGCBD_00210 6.7e-65 2.7.13.3 T Histidine kinase
HOLAGCBD_00211 1.9e-113 K helix_turn_helix, Lux Regulon
HOLAGCBD_00212 0.0 KLT Lanthionine synthetase C-like protein
HOLAGCBD_00213 3.6e-137 3.6.3.44 V ABC transporter
HOLAGCBD_00214 1e-157 msbA2 3.6.3.44 V ABC transporter transmembrane region
HOLAGCBD_00215 1.5e-158 O Thioredoxin
HOLAGCBD_00216 7.6e-129 E Psort location Cytoplasmic, score 8.87
HOLAGCBD_00217 9.1e-133 yebE S DUF218 domain
HOLAGCBD_00218 1.2e-231 tig D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
HOLAGCBD_00219 9e-237 rnd 3.1.13.5 J 3'-5' exonuclease
HOLAGCBD_00220 9.9e-80 S Protein of unknown function (DUF3000)
HOLAGCBD_00221 7.4e-166 pflA 1.97.1.4 C Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HOLAGCBD_00222 0.0 pflB 2.3.1.54 C Pyruvate formate lyase-like
HOLAGCBD_00223 4.5e-31
HOLAGCBD_00224 0.0 nadE 6.3.1.5, 6.3.5.1 H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HOLAGCBD_00225 1.8e-225 S Peptidase dimerisation domain
HOLAGCBD_00226 4.8e-156 S Sucrose-6F-phosphate phosphohydrolase
HOLAGCBD_00227 7.4e-147 metQ P NLPA lipoprotein
HOLAGCBD_00228 4.2e-147 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HOLAGCBD_00229 5.4e-108 metI P Binding-protein-dependent transport system inner membrane component
HOLAGCBD_00230 1.1e-74
HOLAGCBD_00232 3.9e-16 S Psort location Cytoplasmic, score 8.87
HOLAGCBD_00233 3.5e-100 V Abi-like protein
HOLAGCBD_00234 7.7e-27 L Helix-turn-helix domain
HOLAGCBD_00236 0.0 S LPXTG-motif cell wall anchor domain protein
HOLAGCBD_00237 2.5e-245 dinF V MatE
HOLAGCBD_00238 1.2e-102 ppiA 5.2.1.8 G PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HOLAGCBD_00239 0.0 relA 2.7.6.5, 3.1.7.2 KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HOLAGCBD_00240 3.2e-83 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
HOLAGCBD_00241 1e-47 S Domain of unknown function (DUF4193)
HOLAGCBD_00242 8.6e-145 S Protein of unknown function (DUF3071)
HOLAGCBD_00243 3e-234 S Type I phosphodiesterase / nucleotide pyrophosphatase
HOLAGCBD_00244 0.0 gyrA 5.99.1.3 L DNA topoisomerase (ATP-hydrolyzing)
HOLAGCBD_00245 0.0 lhr L DEAD DEAH box helicase
HOLAGCBD_00246 2.2e-31 yozG K Cro/C1-type HTH DNA-binding domain
HOLAGCBD_00247 2.4e-79 S Protein of unknown function (DUF2975)
HOLAGCBD_00248 2.8e-241 T PhoQ Sensor
HOLAGCBD_00249 1.5e-222 G Major Facilitator Superfamily
HOLAGCBD_00250 0.0 gyrB2 5.99.1.3 L DNA topoisomerase (ATP-hydrolyzing)
HOLAGCBD_00251 3.4e-173 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
HOLAGCBD_00252 1.1e-118
HOLAGCBD_00253 2e-197 crtE 2.5.1.1, 2.5.1.10, 2.5.1.29 H Belongs to the FPP GGPP synthase family
HOLAGCBD_00254 0.0 pknL 2.7.11.1 KLT PASTA
HOLAGCBD_00255 9.5e-132 plsC2 2.3.1.51 I Phosphate acyltransferases
HOLAGCBD_00256 1.3e-97
HOLAGCBD_00257 3.4e-194 trpD 2.4.2.18, 4.1.3.27 F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HOLAGCBD_00258 0.0 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
HOLAGCBD_00259 3.3e-118 hpf J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HOLAGCBD_00260 1.5e-121 recX S Modulates RecA activity
HOLAGCBD_00261 5.4e-212 recA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HOLAGCBD_00262 3e-46 S Protein of unknown function (DUF3046)
HOLAGCBD_00263 1.6e-80 K Helix-turn-helix XRE-family like proteins
HOLAGCBD_00264 3.6e-97 cinA 3.5.1.42 S Belongs to the CinA family
HOLAGCBD_00265 2e-123 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HOLAGCBD_00266 0.0 ftsK D FtsK SpoIIIE family protein
HOLAGCBD_00267 1.9e-192 miaA 2.5.1.75 F Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HOLAGCBD_00268 1e-281 miaB 2.8.4.3 H Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HOLAGCBD_00269 1.1e-155 relA2 2.7.6.5 S Region found in RelA / SpoT proteins
HOLAGCBD_00270 8e-177 ydeD EG EamA-like transporter family
HOLAGCBD_00271 1.7e-127 ybhL S Belongs to the BI1 family
HOLAGCBD_00272 1.4e-57 S Domain of unknown function (DUF5067)
HOLAGCBD_00273 5.1e-243 T Histidine kinase
HOLAGCBD_00274 1.8e-127 K helix_turn_helix, Lux Regulon
HOLAGCBD_00275 0.0 S Protein of unknown function DUF262
HOLAGCBD_00276 9e-116 K helix_turn_helix, Lux Regulon
HOLAGCBD_00277 1.1e-245 T Histidine kinase
HOLAGCBD_00278 4.4e-191 V ATPases associated with a variety of cellular activities
HOLAGCBD_00279 7.7e-225 V ABC-2 family transporter protein
HOLAGCBD_00280 8.9e-229 V ABC-2 family transporter protein
HOLAGCBD_00281 9.8e-213 rhaR1 K helix_turn_helix, arabinose operon control protein
HOLAGCBD_00282 5.2e-108 maa 2.3.1.18, 2.3.1.79 S Bacterial transferase hexapeptide repeat protein
HOLAGCBD_00283 3.7e-249 VP1224 V Psort location CytoplasmicMembrane, score 9.99
HOLAGCBD_00284 0.0 acnA 4.2.1.3 C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HOLAGCBD_00285 0.0 ctpE P E1-E2 ATPase
HOLAGCBD_00286 2e-74
HOLAGCBD_00287 3.7e-243 trmA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HOLAGCBD_00288 2.4e-133 S Protein of unknown function (DUF3159)
HOLAGCBD_00289 1.7e-151 S Protein of unknown function (DUF3710)
HOLAGCBD_00290 3e-172 exoA 3.1.11.2 L Endonuclease/Exonuclease/phosphatase family
HOLAGCBD_00291 0.0 dppD EP Oligopeptide/dipeptide transporter, C-terminal region
HOLAGCBD_00292 4.1e-170 dppC EP N-terminal TM domain of oligopeptide transport permease C
HOLAGCBD_00293 1.6e-155 dppB EP Binding-protein-dependent transport system inner membrane component
HOLAGCBD_00294 0.0 E ABC transporter, substrate-binding protein, family 5
HOLAGCBD_00295 0.0 E ABC transporter, substrate-binding protein, family 5
HOLAGCBD_00296 1.6e-171 xerC D Belongs to the 'phage' integrase family. XerC subfamily
HOLAGCBD_00297 4.4e-42
HOLAGCBD_00298 8.9e-195 tyrA 1.3.1.12, 1.3.1.43 E Prephenate dehydrogenase
HOLAGCBD_00299 2.8e-190 pheA 1.3.1.12, 4.2.1.51, 5.4.99.5 E Prephenate dehydratase
HOLAGCBD_00300 4.4e-103
HOLAGCBD_00301 0.0 typA T Elongation factor G C-terminus
HOLAGCBD_00302 1.7e-249 naiP U Sugar (and other) transporter
HOLAGCBD_00303 2.1e-151 nrtR 3.6.1.55 F NUDIX hydrolase
HOLAGCBD_00304 6.8e-153 soj D CobQ CobB MinD ParA nucleotide binding domain protein
HOLAGCBD_00305 2e-177 xerD D recombinase XerD
HOLAGCBD_00306 9.6e-62 rplT J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HOLAGCBD_00307 2.1e-25 rpmI J Ribosomal protein L35
HOLAGCBD_00308 1.6e-103 infC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HOLAGCBD_00309 4.9e-110 2.7.6.2 H Thiamin pyrophosphokinase, vitamin B1 binding domain
HOLAGCBD_00310 1.8e-198 gap 1.2.1.12 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
HOLAGCBD_00311 2.1e-88 ybaK J Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HOLAGCBD_00312 7.9e-172 ispH 1.17.7.4, 2.7.4.25 IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HOLAGCBD_00313 6.3e-187 galM 5.1.3.3 G Aldose 1-epimerase
HOLAGCBD_00314 4.1e-37
HOLAGCBD_00315 1.1e-98 sigH K Belongs to the sigma-70 factor family. ECF subfamily
HOLAGCBD_00316 1.6e-280 murE 6.3.2.13, 6.3.2.7 M Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HOLAGCBD_00317 5e-187 V Acetyltransferase (GNAT) domain
HOLAGCBD_00318 3.3e-289 folC 6.3.2.12, 6.3.2.17 H Mur ligase middle domain
HOLAGCBD_00319 0.0 pepP 3.4.11.9 E Aminopeptidase P, N-terminal domain
HOLAGCBD_00320 9e-95 3.6.1.55 F NUDIX domain
HOLAGCBD_00321 0.0 P Belongs to the ABC transporter superfamily
HOLAGCBD_00322 4.7e-192 dppC EP Binding-protein-dependent transport system inner membrane component
HOLAGCBD_00323 4.2e-187 dppB EP Binding-protein-dependent transport system inner membrane component
HOLAGCBD_00324 1.4e-306 ddpA E Bacterial extracellular solute-binding proteins, family 5 Middle
HOLAGCBD_00325 1.7e-218 GK ROK family
HOLAGCBD_00326 4.9e-165 2.7.1.4 G pfkB family carbohydrate kinase
HOLAGCBD_00327 3.5e-220 S Metal-independent alpha-mannosidase (GH125)
HOLAGCBD_00328 1.6e-27
HOLAGCBD_00329 8.4e-248 yihS 5.1.3.11 G N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)
HOLAGCBD_00330 1.7e-140 ftsQ 6.3.2.4 D Cell division protein FtsQ
HOLAGCBD_00331 2.3e-271 murC 6.3.2.8 M Belongs to the MurCDEF family
HOLAGCBD_00332 6.3e-216 murG 2.4.1.227, 6.3.2.8 GT28 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HOLAGCBD_00333 8.1e-203 ftsW 2.4.1.227 GT28 D Belongs to the SEDS family
HOLAGCBD_00334 2.1e-255 murD 6.3.2.9 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HOLAGCBD_00335 8.8e-193 mraY 2.7.8.13 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HOLAGCBD_00336 1.6e-261 murF 6.3.2.10 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
HOLAGCBD_00337 1.1e-153 yqeC 6.3.2.10, 6.3.2.13 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HOLAGCBD_00338 0.0 ftsI 3.4.16.4 M Penicillin-binding protein, transpeptidase domain protein
HOLAGCBD_00339 1.8e-62 ftsL D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HOLAGCBD_00340 1.3e-190 rsmH 2.1.1.199 J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
HOLAGCBD_00341 7e-92 mraZ K Belongs to the MraZ family
HOLAGCBD_00342 0.0 L DNA helicase
HOLAGCBD_00343 8.7e-218 serA 1.1.1.399, 1.1.1.95 EH D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
HOLAGCBD_00344 2.9e-84 nrdR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HOLAGCBD_00345 1e-53 M Lysin motif
HOLAGCBD_00346 2.2e-131 lexA 3.4.21.88 K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HOLAGCBD_00347 1.3e-149 czcD P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HOLAGCBD_00348 2.3e-176 ldh 1.1.1.27, 1.1.1.37 C Belongs to the LDH MDH superfamily. LDH family
HOLAGCBD_00349 4.9e-271 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HOLAGCBD_00350 5.9e-114 rsmC 2.1.1.172 J Ribosomal protein L11 methyltransferase (PrmA)
HOLAGCBD_00351 0.0 hrpA 3.6.4.13 L Helicase associated domain (HA2) Add an annotation
HOLAGCBD_00352 6.2e-191
HOLAGCBD_00353 2.3e-185 V N-Acetylmuramoyl-L-alanine amidase
HOLAGCBD_00354 1.5e-89
HOLAGCBD_00355 3.2e-118 ytrE V ATPases associated with a variety of cellular activities
HOLAGCBD_00356 9.5e-220 EGP Major facilitator Superfamily
HOLAGCBD_00357 3.6e-139 M Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HOLAGCBD_00358 4.8e-218 S Domain of unknown function (DUF5067)
HOLAGCBD_00359 3.1e-264 glnA2 6.3.1.2 E glutamine synthetase
HOLAGCBD_00360 1.4e-130 hisA 5.3.1.16, 5.3.1.24 E Histidine biosynthesis protein
HOLAGCBD_00361 2.6e-120 hisH E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HOLAGCBD_00362 1.5e-122
HOLAGCBD_00363 1.5e-109 hisB 1.1.1.23, 2.6.1.9, 3.1.3.15, 4.2.1.19 E Imidazoleglycerol-phosphate dehydratase
HOLAGCBD_00364 2.5e-225 hisC 2.6.1.9 E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HOLAGCBD_00365 1.2e-258 hisD 1.1.1.23, 1.1.1.308 E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HOLAGCBD_00366 0.0 dnaE 2.7.7.7 L DNA polymerase III alpha subunit
HOLAGCBD_00367 4.9e-176 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 J Responsible for synthesis of pseudouridine from uracil
HOLAGCBD_00368 9.5e-87 lspA 3.4.23.36 MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HOLAGCBD_00369 4.5e-31 3.1.21.3 V DivIVA protein
HOLAGCBD_00370 1.2e-40 yggT S YGGT family
HOLAGCBD_00371 8.9e-81 sepF D Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
HOLAGCBD_00372 5.6e-220 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HOLAGCBD_00373 1.1e-244 dus J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HOLAGCBD_00374 1.3e-295 glyQS 6.1.1.14 J Catalyzes the attachment of glycine to tRNA(Gly)
HOLAGCBD_00375 1e-105 S Pilus assembly protein, PilO
HOLAGCBD_00376 8.1e-166 pilN NU PFAM Fimbrial assembly family protein
HOLAGCBD_00377 3e-190 pilM NU Type IV pilus assembly protein PilM;
HOLAGCBD_00378 2e-149 pilD 3.4.23.43 NOU Bacterial Peptidase A24 N-terminal domain
HOLAGCBD_00379 0.0
HOLAGCBD_00380 3.8e-230 pilC U Type II secretion system (T2SS), protein F
HOLAGCBD_00381 2.4e-46 pilA NU Prokaryotic N-terminal methylation motif
HOLAGCBD_00382 2.1e-104 S Prokaryotic N-terminal methylation motif
HOLAGCBD_00383 2.4e-136 ppdC NU Prokaryotic N-terminal methylation motif
HOLAGCBD_00384 0.0 pulE NU Type II/IV secretion system protein
HOLAGCBD_00385 0.0 pilT NU Type II/IV secretion system protein
HOLAGCBD_00386 0.0
HOLAGCBD_00387 9.9e-155 thiM 2.7.1.50 H Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HOLAGCBD_00388 3.2e-133 thiE 2.5.1.3, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
HOLAGCBD_00389 1.2e-149 thiD 2.5.1.3, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Phosphomethylpyrimidine kinase
HOLAGCBD_00390 3e-60 S Thiamine-binding protein
HOLAGCBD_00391 5.4e-192 K helix_turn _helix lactose operon repressor
HOLAGCBD_00392 2.8e-241 lacY P LacY proton/sugar symporter
HOLAGCBD_00393 0.0 cscA 3.2.1.26 GH32 G Belongs to the glycosyl hydrolase 32 family
HOLAGCBD_00394 1.9e-142 ytlD1 2.7.1.50 P Binding-protein-dependent transport system inner membrane component
HOLAGCBD_00395 2.6e-205 P NMT1/THI5 like
HOLAGCBD_00396 7.8e-217 iunH1 3.2.2.1 F nucleoside hydrolase
HOLAGCBD_00397 4e-155 uppS 2.5.1.31, 2.5.1.86, 2.5.1.88 H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HOLAGCBD_00398 7.3e-135 recO L Involved in DNA repair and RecF pathway recombination
HOLAGCBD_00399 0.0 I acetylesterase activity
HOLAGCBD_00400 5.6e-225 ispG 1.17.7.1, 1.17.7.3 I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HOLAGCBD_00401 8.5e-218 dxr 1.1.1.267 I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
HOLAGCBD_00402 5.2e-239 2.7.11.1 NU Tfp pilus assembly protein FimV
HOLAGCBD_00404 6.5e-75 S Protein of unknown function (DUF3052)
HOLAGCBD_00405 1e-154 lon T Belongs to the peptidase S16 family
HOLAGCBD_00406 1.6e-283 S Zincin-like metallopeptidase
HOLAGCBD_00407 1.6e-282 uvrD2 3.6.4.12 L DNA helicase
HOLAGCBD_00408 4.7e-269 mphA S Aminoglycoside phosphotransferase
HOLAGCBD_00409 3.6e-32 S Protein of unknown function (DUF3107)
HOLAGCBD_00410 1.1e-172 PPA1328 3.1.3.97 S DNA polymerase alpha chain like domain
HOLAGCBD_00411 2.1e-117 S Vitamin K epoxide reductase
HOLAGCBD_00412 8.6e-170 dapF 5.1.1.7 E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine
HOLAGCBD_00413 2.2e-145 murI 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
HOLAGCBD_00414 3.5e-21 S Patatin-like phospholipase
HOLAGCBD_00415 8.6e-301 E ABC transporter, substrate-binding protein, family 5
HOLAGCBD_00416 3.8e-176 iaaA 3.4.19.5, 3.5.1.1 E Asparaginase
HOLAGCBD_00417 2.9e-159 S Patatin-like phospholipase
HOLAGCBD_00418 1.9e-186 K LysR substrate binding domain protein
HOLAGCBD_00419 2.4e-239 patB 4.4.1.8 E Aminotransferase, class I II
HOLAGCBD_00420 1.6e-120 S Phospholipase/Carboxylesterase
HOLAGCBD_00421 1.9e-46 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HOLAGCBD_00422 7.2e-197 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HOLAGCBD_00423 1.7e-130 cas4 3.1.12.1 L Domain of unknown function DUF83
HOLAGCBD_00424 4.5e-152 csd2 L CRISPR-associated protein Cas7
HOLAGCBD_00425 0.0 csd1 3.5.1.28 M CRISPR-associated protein (Cas_Csd1)
HOLAGCBD_00426 1.2e-137 cas5d S CRISPR-associated protein (Cas_Cas5)
HOLAGCBD_00427 0.0 cas3 L DEAD-like helicases superfamily
HOLAGCBD_00428 0.0 ileS 6.1.1.5 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HOLAGCBD_00429 1e-257 lacS G Psort location CytoplasmicMembrane, score 10.00
HOLAGCBD_00430 9e-184 lacR K Transcriptional regulator, LacI family
HOLAGCBD_00431 0.0 V ABC transporter transmembrane region
HOLAGCBD_00432 0.0 V ABC transporter, ATP-binding protein
HOLAGCBD_00433 1.3e-96 K MarR family
HOLAGCBD_00434 0.0 bglB 3.2.1.21 GH3 G Glycosyl hydrolase family 3 N-terminal domain protein
HOLAGCBD_00435 5.1e-107 K Bacterial regulatory proteins, tetR family
HOLAGCBD_00436 7.8e-209 glxK 2.7.1.165 G Belongs to the glycerate kinase type-1 family
HOLAGCBD_00437 0.0 bgl2 3.2.1.21 GH3 G Fibronectin type III-like domain
HOLAGCBD_00438 2.3e-108 K Bacterial regulatory proteins, tetR family
HOLAGCBD_00439 1.1e-239 3.2.1.58 G Belongs to the glycosyl hydrolase 5 (cellulase A) family
HOLAGCBD_00440 0.0 3.2.1.37 GH43 G Glycosyl hydrolases family 43
HOLAGCBD_00441 8.9e-247 3.2.1.58 G Belongs to the glycosyl hydrolase 5 (cellulase A) family
HOLAGCBD_00442 9.3e-199 P Major Facilitator Superfamily
HOLAGCBD_00443 2.8e-69 dap2 E peptidase
HOLAGCBD_00444 3.1e-19 Q Belongs to the P-Pant transferase superfamily
HOLAGCBD_00445 2e-130 ydjE EGP Major facilitator Superfamily
HOLAGCBD_00446 1.9e-209 hsvB 6.3.2.4 M Belongs to the D-alanine--D-alanine ligase family
HOLAGCBD_00447 4.4e-08 Q Non-ribosomal peptide synthetase modules and related proteins
HOLAGCBD_00449 1.2e-271 srfJ1 3.2.1.45 GH30 G Glycosyl hydrolase family 30 TIM-barrel domain
HOLAGCBD_00451 1.9e-218 G Transporter major facilitator family protein
HOLAGCBD_00452 1.7e-111 K Bacterial regulatory proteins, tetR family
HOLAGCBD_00453 0.0 lacZ3 3.2.1.23 G Beta-galactosidase trimerisation domain
HOLAGCBD_00454 9.4e-115 K Bacterial regulatory proteins, tetR family
HOLAGCBD_00455 5.5e-255 gshA 6.3.2.2 H Glutamate-cysteine ligase family 2(GCS2)
HOLAGCBD_00456 0.0 hgdC I CoA enzyme activase uncharacterised domain (DUF2229)
HOLAGCBD_00457 3.9e-156 hgdC I BadF/BadG/BcrA/BcrD ATPase family
HOLAGCBD_00458 1.1e-138 nrdG 1.97.1.4 O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HOLAGCBD_00459 0.0 nrdD 1.1.98.6 F Anaerobic ribonucleoside-triphosphate reductase
HOLAGCBD_00460 1.5e-244 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HOLAGCBD_00461 7e-41 xseB 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HOLAGCBD_00463 6.2e-199 S Endonuclease/Exonuclease/phosphatase family
HOLAGCBD_00464 3.4e-22 M cell wall anchor domain protein
HOLAGCBD_00465 1.3e-99 tmp1 S Domain of unknown function (DUF4391)
HOLAGCBD_00466 3e-168 ppx 3.6.1.11, 3.6.1.40 FP Ppx/GppA phosphatase family
HOLAGCBD_00467 1.1e-233 aspB E Aminotransferase class-V
HOLAGCBD_00468 1.9e-70 vsr L May nick specific sequences that contain T G mispairs resulting from m5C-deamination
HOLAGCBD_00469 7.2e-189 afr_2 S Oxidoreductase family, NAD-binding Rossmann fold
HOLAGCBD_00470 0.0 helD 3.6.4.12 L Psort location Cytoplasmic, score 8.87
HOLAGCBD_00471 5.4e-141 V Domain of unknown function (DUF3427)
HOLAGCBD_00472 4e-53 K TfoX N-terminal domain
HOLAGCBD_00473 9.2e-25 S Polyketide cyclase / dehydrase and lipid transport
HOLAGCBD_00474 1.2e-88 folA 1.5.1.3 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HOLAGCBD_00475 1.7e-87 3.1.21.7 L 6-O-methylguanine DNA methyltransferase, DNA binding domain
HOLAGCBD_00477 1.8e-49 V Domain of unknown function (DUF3427)
HOLAGCBD_00478 1.5e-76
HOLAGCBD_00479 7.5e-71 S Bacterial PH domain
HOLAGCBD_00480 2.5e-247 S zinc finger
HOLAGCBD_00481 5.7e-85 K Cro/C1-type HTH DNA-binding domain
HOLAGCBD_00482 0.0 pacL2 3.6.3.8 P Cation transporter/ATPase, N-terminus
HOLAGCBD_00483 0.0 lacL 3.2.1.23 G Psort location Cytoplasmic, score 8.87
HOLAGCBD_00484 2.5e-116 S Short repeat of unknown function (DUF308)
HOLAGCBD_00485 2.7e-49 S Antitoxin component of a toxin-antitoxin (TA) module
HOLAGCBD_00486 3.7e-54 DJ Addiction module toxin, RelE StbE family
HOLAGCBD_00487 4.5e-13 S Psort location Extracellular, score 8.82
HOLAGCBD_00488 5e-232 EGP Major facilitator Superfamily
HOLAGCBD_00489 1.2e-175 rlmB 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HOLAGCBD_00490 4.3e-269 KLT Domain of unknown function (DUF4032)
HOLAGCBD_00491 1.6e-210 ugpC E Belongs to the ABC transporter superfamily
HOLAGCBD_00492 1.4e-130 K LytTr DNA-binding domain
HOLAGCBD_00493 1.7e-231 T GHKL domain
HOLAGCBD_00494 6.4e-58
HOLAGCBD_00495 2.2e-216 clcA_2 P Voltage gated chloride channel
HOLAGCBD_00496 1e-78
HOLAGCBD_00497 2.6e-138
HOLAGCBD_00498 6.5e-179 3.4.22.70 M Sortase family
HOLAGCBD_00499 1e-293 M LPXTG-motif cell wall anchor domain protein
HOLAGCBD_00500 0.0 S LPXTG-motif cell wall anchor domain protein
HOLAGCBD_00501 1.3e-72 S GtrA-like protein
HOLAGCBD_00502 0.0 3.2.1.21 GH3 G Glycosyl hydrolase family 3 N-terminal domain protein
HOLAGCBD_00503 3.4e-121 ybjG 3.6.1.27 I Psort location CytoplasmicMembrane, score
HOLAGCBD_00504 8.1e-81 ypeA 2.3.1.1 K Psort location Cytoplasmic, score 8.87
HOLAGCBD_00505 1.1e-113 vex2 V ABC transporter, ATP-binding protein
HOLAGCBD_00506 4.5e-214 vex1 V Efflux ABC transporter, permease protein
HOLAGCBD_00507 3.4e-242 vex3 V ABC transporter permease
HOLAGCBD_00508 4.7e-34 lacS G Psort location CytoplasmicMembrane, score 10.00
HOLAGCBD_00509 3.3e-43 3.6.4.12 K Putative ATP-dependent DNA helicase recG C-terminal
HOLAGCBD_00510 3e-229 yhjX EGP Major facilitator Superfamily
HOLAGCBD_00511 0.0 trxB1 1.8.1.9 C Thioredoxin domain
HOLAGCBD_00512 1.7e-107 ahpC 1.11.1.15 O C-terminal domain of 1-Cys peroxiredoxin
HOLAGCBD_00513 2.2e-88 I alpha/beta hydrolase fold
HOLAGCBD_00515 8e-145 cobB2 K Sir2 family
HOLAGCBD_00516 4.1e-234 tdcB 4.3.1.19 E Pyridoxal-phosphate dependent enzyme
HOLAGCBD_00517 0.0 3.2.1.10 GH13 G Alpha amylase, catalytic domain protein
HOLAGCBD_00518 4.4e-158 G Binding-protein-dependent transport system inner membrane component
HOLAGCBD_00519 1.2e-158 G Binding-protein-dependent transport system inner membrane component
HOLAGCBD_00520 4.4e-244 msmE7 G Bacterial extracellular solute-binding protein
HOLAGCBD_00521 2.2e-229 nagC GK ROK family
HOLAGCBD_00522 0.0 3.2.1.22 G Glycosyl hydrolase family 36 N-terminal domain
HOLAGCBD_00523 1.4e-77 tadA 3.5.4.1, 3.5.4.33, 3.8.1.5, 6.3.4.19 FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
HOLAGCBD_00524 0.0 yjcE P Sodium/hydrogen exchanger family
HOLAGCBD_00525 1e-153 ypfH S Phospholipase/Carboxylesterase
HOLAGCBD_00526 4e-112 dcd 3.5.4.13 F Belongs to the dCTP deaminase family
HOLAGCBD_00527 8.6e-56 KLT Protein tyrosine kinase
HOLAGCBD_00528 2.8e-258 EGP Transmembrane secretion effector
HOLAGCBD_00529 2.8e-22 V Type II restriction enzyme, methylase subunits
HOLAGCBD_00530 3.3e-155 ksgA 2.1.1.182, 2.1.1.184 J Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family
HOLAGCBD_00531 9.2e-110 G Binding-protein-dependent transport system inner membrane component
HOLAGCBD_00532 3.1e-28 G ABC transporter permease
HOLAGCBD_00533 4.8e-38 G ABC transporter permease
HOLAGCBD_00534 3.8e-29 L transposase activity
HOLAGCBD_00535 9.3e-108 L Transposase and inactivated derivatives
HOLAGCBD_00536 4.6e-25 G Binding-protein-dependent transport system inner membrane component
HOLAGCBD_00537 3.7e-16 feoB P transporter of a GTP-driven Fe(2 ) uptake system
HOLAGCBD_00538 1.2e-117
HOLAGCBD_00539 9.8e-181 MA20_14895 S Conserved hypothetical protein 698
HOLAGCBD_00540 1.9e-218 C Na H antiporter family protein
HOLAGCBD_00541 1e-157 korD 1.2.7.3 C Domain of unknown function (DUF362)
HOLAGCBD_00542 1.3e-95 2.7.1.48 F uridine kinase
HOLAGCBD_00543 1.9e-93 S ECF transporter, substrate-specific component
HOLAGCBD_00544 3.6e-138 S Sulfite exporter TauE/SafE
HOLAGCBD_00545 7e-141 K helix_turn_helix, arabinose operon control protein
HOLAGCBD_00546 5.4e-155 3.1.3.73 G Phosphoglycerate mutase family
HOLAGCBD_00547 2.4e-234 rutG F Permease family
HOLAGCBD_00548 4.2e-127 S Enoyl-(Acyl carrier protein) reductase
HOLAGCBD_00549 1.6e-272 deaD 3.6.4.13 JKL helicase superfamily c-terminal domain
HOLAGCBD_00550 5.1e-134 ybbM V Uncharacterised protein family (UPF0014)
HOLAGCBD_00551 1.9e-142 ybbL V ATPases associated with a variety of cellular activities
HOLAGCBD_00552 4.7e-239 S Putative esterase
HOLAGCBD_00553 0.0 lysX S Uncharacterised conserved protein (DUF2156)
HOLAGCBD_00554 1.2e-277 gnd 1.1.1.343, 1.1.1.44 H Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HOLAGCBD_00555 3.4e-146 S Belongs to the short-chain dehydrogenases reductases (SDR) family
HOLAGCBD_00556 9.4e-219 patB 4.4.1.8 E Aminotransferase, class I II
HOLAGCBD_00557 1.8e-303 zwf 1.1.1.363, 1.1.1.49 G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HOLAGCBD_00558 5e-176 opcA G Glucose-6-phosphate dehydrogenase subunit
HOLAGCBD_00559 4.9e-145 pgl 3.1.1.31, 3.5.99.6 G Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
HOLAGCBD_00560 1.8e-81 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
HOLAGCBD_00561 1.9e-86 M Protein of unknown function (DUF3737)
HOLAGCBD_00562 1.1e-141 azlC E AzlC protein
HOLAGCBD_00563 3.2e-53 azlD E Branched-chain amino acid transport protein (AzlD)
HOLAGCBD_00564 0.0 cstA T 5TM C-terminal transporter carbon starvation CstA
HOLAGCBD_00565 6.2e-40 ybdD S Selenoprotein, putative
HOLAGCBD_00566 4.9e-176 ybbD 3.2.1.52 G Glycosyl hydrolase family 3 N-terminal domain protein
HOLAGCBD_00567 0.0 S Uncharacterised protein family (UPF0182)
HOLAGCBD_00568 3.6e-99 2.3.1.183 M Acetyltransferase (GNAT) domain
HOLAGCBD_00569 1.7e-113 pth 3.1.1.29 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
HOLAGCBD_00570 0.0 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HOLAGCBD_00571 1.5e-244 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
HOLAGCBD_00572 2e-71 divIC D Septum formation initiator
HOLAGCBD_00573 1.3e-102 ppx2 3.6.1.11, 3.6.1.40 S Protein of unknown function (DUF501)
HOLAGCBD_00574 3.2e-181 ppx 3.6.1.11, 3.6.1.40 FP Ppx/GppA phosphatase family
HOLAGCBD_00576 2.3e-91
HOLAGCBD_00577 2.5e-283 sdaA 4.3.1.17 E Serine dehydratase alpha chain
HOLAGCBD_00578 1.2e-73 fkbP 5.2.1.8 G Peptidyl-prolyl cis-trans
HOLAGCBD_00579 2.6e-80 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
HOLAGCBD_00580 2.7e-144 yplQ S Haemolysin-III related
HOLAGCBD_00581 6e-277 pdtaS 2.7.13.3 T ATPase histidine kinase DNA gyrase B HSP90 domain protein
HOLAGCBD_00582 1.9e-46 whiB K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA
HOLAGCBD_00583 0.0 D FtsK/SpoIIIE family
HOLAGCBD_00584 6.9e-170 K Cell envelope-related transcriptional attenuator domain
HOLAGCBD_00586 5.7e-208 K Cell envelope-related transcriptional attenuator domain
HOLAGCBD_00587 3.4e-54 whiB K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA
HOLAGCBD_00588 0.0 S Glycosyl transferase, family 2
HOLAGCBD_00589 4.8e-213
HOLAGCBD_00590 1.5e-71 MA20_43655 2.7.2.8 S Zincin-like metallopeptidase
HOLAGCBD_00591 1.1e-152 cof 5.2.1.8 T Eukaryotic phosphomannomutase
HOLAGCBD_00592 8.5e-139 ctsW S Phosphoribosyl transferase domain
HOLAGCBD_00593 6.8e-188 T ATPase histidine kinase DNA gyrase B HSP90 domain protein
HOLAGCBD_00594 7.8e-129 T Response regulator receiver domain protein
HOLAGCBD_00595 0.0 glgB 2.4.1.18 CBM48,GH13 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HOLAGCBD_00596 3e-102 carD K CarD-like/TRCF domain
HOLAGCBD_00597 1.3e-87 ispF 2.1.1.228, 2.7.7.60, 4.6.1.12 H Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)
HOLAGCBD_00598 5.1e-140 znuB U ABC 3 transport family
HOLAGCBD_00599 2e-160 znuC P ATPases associated with a variety of cellular activities
HOLAGCBD_00600 6.5e-172 P Zinc-uptake complex component A periplasmic
HOLAGCBD_00601 1.9e-161 folD 1.5.1.5, 3.5.4.9 F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HOLAGCBD_00602 8.3e-255 rpsA J Ribosomal protein S1
HOLAGCBD_00603 9.1e-116 coaE 2.7.1.24 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HOLAGCBD_00604 0.0 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
HOLAGCBD_00605 8.8e-176 terC P Integral membrane protein, TerC family
HOLAGCBD_00606 2.3e-273 pyk 2.7.1.40 G Pyruvate kinase
HOLAGCBD_00608 1.3e-187 hbd2 1.1.1.157 I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
HOLAGCBD_00609 6.6e-167 yeaD 4.2.1.9, 5.1.3.15 G Aldose 1-epimerase
HOLAGCBD_00610 9.4e-101 pdtaR T Response regulator receiver domain protein
HOLAGCBD_00611 0.0 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HOLAGCBD_00612 2.8e-168 yqfO 3.5.4.16 L NIF3 (NGG1p interacting factor 3)
HOLAGCBD_00613 1.9e-121 3.6.1.13 L NUDIX domain
HOLAGCBD_00614 0.0 glgX 3.2.1.68 CBM48,GH13 G Belongs to the glycosyl hydrolase 13 family
HOLAGCBD_00615 4.1e-212 ykiI
HOLAGCBD_00617 3e-251 aroA 2.5.1.19 E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
HOLAGCBD_00618 8.7e-303 guaA 6.3.5.2 F Catalyzes the synthesis of GMP from XMP
HOLAGCBD_00619 0.0 xfp 4.1.2.22, 4.1.2.9 G D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase
HOLAGCBD_00620 6e-302 pta 1.1.1.40, 2.3.1.19, 2.3.1.8, 3.6.3.21 C phosphate acetyltransferase
HOLAGCBD_00621 1.7e-232 ackA 2.7.2.1, 2.7.2.15 H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HOLAGCBD_00622 0.0 yrhL I Psort location CytoplasmicMembrane, score 9.99
HOLAGCBD_00623 2.8e-244 pbuX F Permease family
HOLAGCBD_00624 1.5e-106 xpt 2.4.2.22, 2.4.2.7 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
HOLAGCBD_00625 0.0 pcrA 3.6.4.12 L DNA helicase
HOLAGCBD_00626 1.7e-61 S Domain of unknown function (DUF4418)
HOLAGCBD_00627 2.2e-213 V FtsX-like permease family
HOLAGCBD_00628 7e-150 lolD V ABC transporter
HOLAGCBD_00629 3.1e-110 rpsD J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HOLAGCBD_00630 4.5e-51 yvlD S Mycobacterial 4 TMS phage holin, superfamily IV
HOLAGCBD_00631 1.6e-128 pgm3 G Phosphoglycerate mutase family
HOLAGCBD_00632 3.4e-59 WQ51_05790 S Bacterial protein of unknown function (DUF948)
HOLAGCBD_00633 2.5e-36
HOLAGCBD_00634 0.0 alaS 6.1.1.7 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HOLAGCBD_00635 2.7e-82 yqgF L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HOLAGCBD_00636 8.9e-191 mltG S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HOLAGCBD_00637 9.3e-57 3.4.23.43 S Type IV leader peptidase family
HOLAGCBD_00638 1.3e-221 aroC 4.2.3.5 E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HOLAGCBD_00639 0.0 aroK 2.7.1.71, 4.2.3.4 H Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HOLAGCBD_00640 4.9e-81 aroQ 4.2.1.10 E Catalyzes a trans-dehydration via an enolate intermediate
HOLAGCBD_00641 0.0 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 M Aamy_C
HOLAGCBD_00642 0.0 pyrG 6.3.4.2 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
HOLAGCBD_00643 0.0 S L,D-transpeptidase catalytic domain
HOLAGCBD_00644 9.6e-291 sufB O FeS assembly protein SufB
HOLAGCBD_00645 1e-234 sufD O FeS assembly protein SufD
HOLAGCBD_00646 1e-142 sufC O FeS assembly ATPase SufC
HOLAGCBD_00647 6.5e-240 sufS 2.8.1.7, 4.4.1.16 E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HOLAGCBD_00648 2.6e-97 iscU C SUF system FeS assembly protein, NifU family
HOLAGCBD_00649 1e-107 yitW S Iron-sulfur cluster assembly protein
HOLAGCBD_00650 8.1e-243 glgC 2.7.7.27 H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HOLAGCBD_00651 2.6e-163 spoU 2.1.1.185 J SpoU rRNA Methylase family
HOLAGCBD_00653 5.9e-138 rsmE 2.1.1.193 J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
HOLAGCBD_00654 1.8e-56 hinT 2.1.1.226, 2.1.1.227 FG Scavenger mRNA decapping enzyme C-term binding
HOLAGCBD_00655 5.9e-208 phoH T PhoH-like protein
HOLAGCBD_00656 9.4e-103 ybeY 2.6.99.2, 3.5.4.5 S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HOLAGCBD_00657 1.2e-250 corC S CBS domain
HOLAGCBD_00658 2e-180 era S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HOLAGCBD_00659 0.0 fadD 6.2.1.3 I AMP-binding enzyme
HOLAGCBD_00660 1.7e-202 pntA 1.6.1.2 C NAD(P) transhydrogenase subunit alpha part 1 K00324
HOLAGCBD_00661 1.6e-43 pntAA 1.6.1.2 C 4TM region of pyridine nucleotide transhydrogenase, mitoch
HOLAGCBD_00662 3.5e-258 pntB 1.6.1.2 C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HOLAGCBD_00663 1.9e-269 S Psort location Cytoplasmic, score 8.87
HOLAGCBD_00665 8.6e-224 G Transmembrane secretion effector
HOLAGCBD_00666 7e-121 K Bacterial regulatory proteins, tetR family
HOLAGCBD_00668 1.1e-39 nrdH O Glutaredoxin
HOLAGCBD_00669 3.3e-74 nrdI F Probably involved in ribonucleotide reductase function
HOLAGCBD_00670 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HOLAGCBD_00672 3.1e-189 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HOLAGCBD_00673 0.0 uvrA3 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HOLAGCBD_00674 2.6e-30 EGP Major facilitator Superfamily
HOLAGCBD_00675 1.3e-25 yhjX EGP Major facilitator Superfamily
HOLAGCBD_00676 3.8e-195 S alpha beta
HOLAGCBD_00677 1e-89 ctc J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HOLAGCBD_00678 1.7e-93 D Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HOLAGCBD_00679 3.2e-54 crcB U Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HOLAGCBD_00680 2.2e-72 K Acetyltransferase (GNAT) domain
HOLAGCBD_00682 1.9e-227 ilvE 2.6.1.42 E Amino-transferase class IV
HOLAGCBD_00683 1.1e-133 S UPF0126 domain
HOLAGCBD_00684 2.9e-33 rpsT J Binds directly to 16S ribosomal RNA
HOLAGCBD_00685 0.0 lepA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
HOLAGCBD_00686 3e-234 hemN H Involved in the biosynthesis of porphyrin-containing compound
HOLAGCBD_00687 5e-145 IQ Oxidoreductase, short chain dehydrogenase reductase family protein
HOLAGCBD_00688 6.9e-289 luxC 1.2.1.50 C Acyl-CoA reductase (LuxC)
HOLAGCBD_00689 1.1e-217 luxE 6.2.1.19 H long-chain-fatty-acid--luciferin-component ligase, acyl-protein synthase
HOLAGCBD_00690 3.3e-234 F Psort location CytoplasmicMembrane, score 10.00
HOLAGCBD_00691 0.0 gltB 1.4.1.13, 1.4.1.14, 1.4.7.1 E glutamate synthase NADPH large subunit
HOLAGCBD_00692 2.6e-307 gltD 1.4.1.13, 1.4.1.14 C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
HOLAGCBD_00693 2e-74
HOLAGCBD_00694 7.6e-249 glgA 2.4.1.342 GT4 G Starch synthase catalytic domain
HOLAGCBD_00695 1.9e-158 modF 3.6.3.21, 3.6.3.34 P ATPases associated with a variety of cellular activities
HOLAGCBD_00696 1.8e-198 trmI 2.1.1.219, 2.1.1.220 J Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HOLAGCBD_00697 4.5e-100 sixA 3.6.1.55 T Phosphoglycerate mutase family
HOLAGCBD_00698 0.0 metE 2.1.1.14 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HOLAGCBD_00699 1.6e-157 metF 1.5.1.20 E Methylenetetrahydrofolate reductase
HOLAGCBD_00700 0.0 glnE 2.7.7.42, 2.7.7.89 H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell
HOLAGCBD_00701 8.7e-187 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
HOLAGCBD_00702 4.2e-74 pyrI 2.1.3.2 F Aspartate carbamoyltransferase regulatory chain, allosteric domain protein
HOLAGCBD_00703 1.1e-277 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
HOLAGCBD_00704 7e-178 pyrF 2.4.2.10, 4.1.1.23 F Belongs to the OMP decarboxylase family. Type 2 subfamily
HOLAGCBD_00705 9.3e-155 pyrK 1.18.1.2, 1.19.1.1, 1.4.1.13, 1.4.1.14 C Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B
HOLAGCBD_00706 6.6e-179 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
HOLAGCBD_00707 1.2e-123 pyrE 2.4.2.10 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HOLAGCBD_00708 2.9e-162 cpsY K Bacterial regulatory helix-turn-helix protein, lysR family
HOLAGCBD_00709 0.0 thiC 2.5.1.3, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HOLAGCBD_00710 4.3e-108 J Acetyltransferase (GNAT) domain
HOLAGCBD_00711 6.1e-69 arsC 1.20.4.1 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HOLAGCBD_00712 2.6e-216 yxjG_1 E Psort location Cytoplasmic, score 8.87
HOLAGCBD_00713 6.1e-122 maa 2.3.1.18, 2.3.1.79 S Maltose acetyltransferase
HOLAGCBD_00714 1.8e-50 sdpR K helix_turn_helix, Arsenical Resistance Operon Repressor
HOLAGCBD_00715 1.4e-139 S SdpI/YhfL protein family
HOLAGCBD_00716 2.1e-109 3.8.1.2 S Haloacid dehalogenase-like hydrolase
HOLAGCBD_00717 0.0 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HOLAGCBD_00718 5e-125 XK27_06785 V ABC transporter
HOLAGCBD_00721 4.3e-63
HOLAGCBD_00722 1.6e-95 M Peptidase family M23
HOLAGCBD_00723 0.0 fadD1 6.2.1.3 I AMP-binding enzyme
HOLAGCBD_00724 1.2e-267 G ABC transporter substrate-binding protein
HOLAGCBD_00725 5.3e-231 icd 1.1.1.42 C Belongs to the isocitrate and isopropylmalate dehydrogenases family
HOLAGCBD_00726 8.1e-210 guaB 1.1.1.205 F IMP dehydrogenase family protein
HOLAGCBD_00727 6.1e-108 dnaQ 2.7.7.7 L Exonuclease, DNA polymerase III, epsilon subunit family
HOLAGCBD_00728 9e-72 U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
HOLAGCBD_00729 2.6e-242 glmU 2.3.1.157, 2.7.7.23 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HOLAGCBD_00730 3.6e-67 rsfS 2.7.7.18 J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
HOLAGCBD_00731 4.3e-143 3.1.3.85, 5.4.2.11, 5.4.2.12 G Phosphoglycerate mutase family
HOLAGCBD_00732 6.2e-117
HOLAGCBD_00734 1.3e-232 XK27_00240 K Fic/DOC family
HOLAGCBD_00735 2.7e-70 pdxH S Pfam:Pyridox_oxidase
HOLAGCBD_00736 4.6e-302 M domain protein
HOLAGCBD_00737 5.6e-83 3.4.22.70 M Sortase family
HOLAGCBD_00738 5.2e-65 3.4.22.70 M Sortase family
HOLAGCBD_00739 1.5e-163 3.1.3.85, 5.4.2.11, 5.4.2.12 G Phosphoglycerate mutase family
HOLAGCBD_00740 5.7e-172 corA P CorA-like Mg2+ transporter protein
HOLAGCBD_00741 1.5e-142 ET Bacterial periplasmic substrate-binding proteins
HOLAGCBD_00742 0.0 leuS 6.1.1.4 J Belongs to the class-I aminoacyl-tRNA synthetase family
HOLAGCBD_00743 3.7e-92 comEA 2.4.1.21 GT5 L Helix-hairpin-helix motif
HOLAGCBD_00744 0.0 comE S Competence protein
HOLAGCBD_00745 6.5e-179 holA 2.7.7.7 L DNA polymerase III delta subunit
HOLAGCBD_00746 9.2e-94 ydiB 2.7.1.221, 5.1.1.1 S Threonylcarbamoyl adenosine biosynthesis protein TsaE
HOLAGCBD_00747 6.4e-148 yeaZ 2.3.1.234 O Glycoprotease family
HOLAGCBD_00748 2.6e-103 rimI 2.3.1.128, 2.3.1.234 K FR47-like protein
HOLAGCBD_00749 3.1e-195 tsaD 2.3.1.234 O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HOLAGCBD_00751 2.6e-119 yoaP E YoaP-like
HOLAGCBD_00752 4.5e-185 cbh 3.5.1.24 M Linear amide C-N hydrolase, choloylglycine hydrolase family protein
HOLAGCBD_00753 5.3e-119 ykoE S ABC-type cobalt transport system, permease component
HOLAGCBD_00754 6.7e-72 K MerR family regulatory protein
HOLAGCBD_00755 4.6e-199 adhB 1.1.1.1, 1.1.1.14 C Zinc-binding dehydrogenase
HOLAGCBD_00756 1.4e-124 4.1.1.44 S Carboxymuconolactone decarboxylase family
HOLAGCBD_00757 5.5e-222 yxjG_1 E Psort location Cytoplasmic, score 8.87
HOLAGCBD_00758 3.6e-76 S Psort location CytoplasmicMembrane, score
HOLAGCBD_00759 1e-182 cat P Cation efflux family
HOLAGCBD_00762 3e-98
HOLAGCBD_00763 2.7e-98
HOLAGCBD_00764 1.5e-146 mazG 3.6.1.66 S Psort location Cytoplasmic, score 8.87
HOLAGCBD_00765 1.5e-277 pepC 3.4.22.40 E Peptidase C1-like family
HOLAGCBD_00766 8.7e-160 S IMP dehydrogenase activity
HOLAGCBD_00767 1.9e-300 ybiT S ABC transporter
HOLAGCBD_00768 4.7e-111 pncA 2.7.11.1, 3.5.1.19 Q Isochorismatase family
HOLAGCBD_00769 2.8e-66 ogt 2.1.1.63 L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HOLAGCBD_00771 2e-13
HOLAGCBD_00772 2e-273 S Psort location Cytoplasmic, score 8.87
HOLAGCBD_00773 6.2e-140 S Domain of unknown function (DUF4194)
HOLAGCBD_00774 0.0 S Psort location Cytoplasmic, score 8.87
HOLAGCBD_00775 2.4e-220 S Psort location Cytoplasmic, score 8.87
HOLAGCBD_00776 0.0 uvrA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
HOLAGCBD_00777 0.0 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
HOLAGCBD_00778 7.1e-183 aroE 1.1.1.25 E Shikimate dehydrogenase substrate binding domain
HOLAGCBD_00779 4e-170 rapZ S Displays ATPase and GTPase activities
HOLAGCBD_00780 1.3e-171 whiA K May be required for sporulation
HOLAGCBD_00781 1.9e-220 pgk 2.7.2.3, 5.3.1.1 F Phosphoglycerate kinase
HOLAGCBD_00782 9.6e-149 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
HOLAGCBD_00783 2.4e-32 secG U Preprotein translocase SecG subunit
HOLAGCBD_00784 3.3e-163 S Sucrose-6F-phosphate phosphohydrolase
HOLAGCBD_00785 8e-301 alaA 2.6.1.2, 2.6.1.66 E Aminotransferase, class I II
HOLAGCBD_00786 7.1e-09 pnuC H Nicotinamide mononucleotide transporter
HOLAGCBD_00787 1.3e-113 pnuC H Nicotinamide mononucleotide transporter
HOLAGCBD_00788 2.2e-36 nadD 2.7.1.22, 2.7.7.1, 2.7.7.18, 3.6.1.55 H ATPase kinase involved in NAD metabolism
HOLAGCBD_00789 2.6e-42 nadR H ATPase kinase involved in NAD metabolism
HOLAGCBD_00790 4.2e-203 tal 2.2.1.2 H Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HOLAGCBD_00791 0.0 tkt 2.2.1.1 H Belongs to the transketolase family
HOLAGCBD_00792 1.1e-195 hrcA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
HOLAGCBD_00793 2.4e-188 dnaJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
HOLAGCBD_00794 2.1e-23 S Putative phage holin Dp-1
HOLAGCBD_00795 1.8e-88 M Glycosyl hydrolases family 25
HOLAGCBD_00797 2.1e-11
HOLAGCBD_00799 5.9e-35 MU outer membrane autotransporter barrel domain protein
HOLAGCBD_00800 5e-43
HOLAGCBD_00801 4.7e-88 L DNA integration
HOLAGCBD_00804 1.9e-189 K Periplasmic binding protein domain
HOLAGCBD_00805 5.3e-229 sstT E Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HOLAGCBD_00806 8.9e-144 rluA 5.4.99.28, 5.4.99.29 J RNA pseudouridylate synthase
HOLAGCBD_00807 0.0 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
HOLAGCBD_00808 8.5e-145 tcyC 3.6.3.21 E ATPases associated with a variety of cellular activities
HOLAGCBD_00809 2.2e-142 yecS E Binding-protein-dependent transport system inner membrane component
HOLAGCBD_00810 6.4e-128 pknD ET ABC transporter, substrate-binding protein, family 3
HOLAGCBD_00811 8.9e-32 pknD ET ABC transporter, substrate-binding protein, family 3
HOLAGCBD_00812 1.1e-156 pknD ET ABC transporter, substrate-binding protein, family 3
HOLAGCBD_00813 2e-77 smpB J the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
HOLAGCBD_00814 8.9e-150 usp 3.5.1.28 CBM50 D CHAP domain protein
HOLAGCBD_00815 3.4e-161 ftsX D Part of the ABC transporter FtsEX involved in cellular division
HOLAGCBD_00816 8.9e-168 ftsE D Cell division ATP-binding protein FtsE
HOLAGCBD_00817 1.1e-190 prfB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HOLAGCBD_00818 4e-81 rlmH 2.1.1.177 J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HOLAGCBD_00819 1.7e-142 dapD 2.3.1.117 E Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA
HOLAGCBD_00820 5.4e-250 gltA 2.3.3.1 C Citrate synthase, C-terminal domain
HOLAGCBD_00821 1.6e-151 map 3.4.11.18 E Methionine aminopeptidase
HOLAGCBD_00822 0.0 pepO 3.4.24.71 O Peptidase family M13
HOLAGCBD_00823 3.1e-98 L Single-strand binding protein family
HOLAGCBD_00824 0.0 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
HOLAGCBD_00825 7.9e-271 recD2 3.6.4.12 L PIF1-like helicase
HOLAGCBD_00826 4.5e-163 supH S Sucrose-6F-phosphate phosphohydrolase
HOLAGCBD_00827 8.2e-122 orn L 3'-to-5' exoribonuclease specific for small oligoribonucleotides
HOLAGCBD_00828 2.2e-287 guaB 1.1.1.205 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
HOLAGCBD_00829 3.2e-193 tagO 2.7.8.33, 2.7.8.35 M Glycosyl transferase family 4
HOLAGCBD_00830 6.4e-114 ywlC 2.7.7.87 J Belongs to the SUA5 family
HOLAGCBD_00831 1.9e-124 livF E ATPases associated with a variety of cellular activities
HOLAGCBD_00832 4.8e-151 E Branched-chain amino acid ATP-binding cassette transporter
HOLAGCBD_00833 6.7e-196 livM U Belongs to the binding-protein-dependent transport system permease family
HOLAGCBD_00834 9.5e-156 U Belongs to the binding-protein-dependent transport system permease family
HOLAGCBD_00835 7.8e-219 livK E Receptor family ligand binding region
HOLAGCBD_00836 3.2e-172 prmC 2.1.1.297 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
HOLAGCBD_00837 1.4e-190 prfA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HOLAGCBD_00838 1.5e-35 rpmE J Binds the 23S rRNA
HOLAGCBD_00840 6.8e-226 xylR GK ROK family
HOLAGCBD_00841 2.9e-287 xylB 1.1.1.57, 2.7.1.17 G FGGY family of carbohydrate kinases, C-terminal domain
HOLAGCBD_00842 2.1e-106 lacA 2.3.1.79 S Bacterial transferase hexapeptide repeat protein
HOLAGCBD_00843 9.7e-09 CE10 I Belongs to the type-B carboxylesterase lipase family
HOLAGCBD_00844 0.0 3.1.1.53 G Glycosyl hydrolase family 2, sugar binding domain protein
HOLAGCBD_00845 0.0 xynB 3.2.1.37 GH43 G Belongs to the glycosyl hydrolase 43 family
HOLAGCBD_00846 2.4e-164 MA20_14020 P Binding-protein-dependent transport system inner membrane component
HOLAGCBD_00847 1.7e-185 MA20_14025 U Binding-protein-dependent transport system inner membrane component
HOLAGCBD_00848 9.4e-239 msmE G ABC transporter periplasmic binding protein YcjN precursor K02027
HOLAGCBD_00849 7.2e-189 K Bacterial regulatory proteins, lacI family
HOLAGCBD_00850 0.0 3.2.1.37, 3.2.1.55 GH43,GH51 G Belongs to the glycosyl hydrolase 43 family
HOLAGCBD_00851 1.3e-267 xylA 5.3.1.5 G Belongs to the xylose isomerase family
HOLAGCBD_00852 2.4e-250 metY 2.5.1.49 H Psort location Cytoplasmic, score 9.98
HOLAGCBD_00853 5.8e-296 S Amidohydrolase family
HOLAGCBD_00854 4.2e-77 gmk 1.1.1.23, 2.7.4.8 S Protein conserved in bacteria
HOLAGCBD_00856 1.8e-174 ribD 1.1.1.193, 3.5.4.26 H Cytidine and deoxycytidylate deaminase zinc-binding region
HOLAGCBD_00857 9.3e-74 def2 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins
HOLAGCBD_00858 5.9e-182 V Beta-lactamase
HOLAGCBD_00859 0.0 yjjK S ATP-binding cassette protein, ChvD family
HOLAGCBD_00860 5e-165 tesB I Thioesterase-like superfamily
HOLAGCBD_00861 6.2e-94 S Protein of unknown function (DUF3180)
HOLAGCBD_00862 7e-273 folK 1.13.11.81, 2.5.1.15, 2.7.6.3, 3.5.4.16, 3.5.4.39, 4.1.2.25, 5.1.99.8 H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HOLAGCBD_00863 1.2e-155 folP 1.13.11.81, 2.5.1.15, 2.7.6.3, 4.1.2.25, 5.1.99.8 H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HOLAGCBD_00864 9.6e-115 folE 2.7.6.3, 3.5.4.16 H GTP cyclohydrolase
HOLAGCBD_00865 0.0 ftsH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HOLAGCBD_00866 3.9e-99 hpt 2.4.2.8, 6.3.4.19 F Belongs to the purine pyrimidine phosphoribosyltransferase family
HOLAGCBD_00867 1.5e-200 tilS 2.4.2.8, 6.3.4.19 J Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
HOLAGCBD_00868 1.1e-232 dacB 3.4.16.4 M D-Ala-D-Ala carboxypeptidase 3 (S13) family
HOLAGCBD_00869 6.3e-232 epsG M Glycosyl transferase family 21
HOLAGCBD_00870 1.3e-237 S AI-2E family transporter
HOLAGCBD_00871 5.5e-180 3.4.14.13 M Glycosyltransferase like family 2
HOLAGCBD_00872 1.8e-204 fucO 1.1.1.1, 1.1.1.77, 1.1.99.37, 1.2.98.1 C Iron-containing alcohol dehydrogenase
HOLAGCBD_00873 0.0 yliE T Putative diguanylate phosphodiesterase
HOLAGCBD_00874 8.5e-111 S Domain of unknown function (DUF4956)
HOLAGCBD_00875 1.4e-158 P VTC domain
HOLAGCBD_00876 0.0 cotH M CotH kinase protein
HOLAGCBD_00877 1.4e-284 pelG S Putative exopolysaccharide Exporter (EPS-E)
HOLAGCBD_00878 1.9e-166 pelF GT4 M Domain of unknown function (DUF3492)
HOLAGCBD_00879 1.6e-103 pelF GT4 M Domain of unknown function (DUF3492)
HOLAGCBD_00880 0.0 S Uncharacterised protein conserved in bacteria (DUF2194)
HOLAGCBD_00881 3e-162
HOLAGCBD_00882 0.0 5.1.3.2 GM ADP-glyceromanno-heptose 6-epimerase activity
HOLAGCBD_00886 2.9e-162 trmB 2.1.1.297, 2.1.1.33, 2.4.99.12, 2.4.99.13, 2.4.99.14, 2.4.99.15 GT30 J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
HOLAGCBD_00887 9e-200 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
HOLAGCBD_00889 3.6e-85 ptpA 3.1.3.48 T low molecular weight
HOLAGCBD_00890 1.6e-128 folA 1.5.1.3 H dihydrofolate reductase
HOLAGCBD_00891 1.9e-180 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HOLAGCBD_00892 1e-72 attW O OsmC-like protein
HOLAGCBD_00893 1.3e-190 T Universal stress protein family
HOLAGCBD_00894 1.3e-79 M NlpC/P60 family
HOLAGCBD_00895 1.6e-166 usp 3.5.1.28 CBM50 S CHAP domain
HOLAGCBD_00896 9.1e-217 serC 2.6.1.52 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HOLAGCBD_00897 6.2e-41
HOLAGCBD_00898 3.6e-216 T ATPase histidine kinase DNA gyrase B HSP90 domain protein
HOLAGCBD_00899 3.3e-89 phoU P Plays a role in the regulation of phosphate uptake
HOLAGCBD_00900 0.0 4.2.1.53 S MCRA family
HOLAGCBD_00901 2.9e-139 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HOLAGCBD_00902 5.6e-203 menA 2.5.1.74 H Belongs to the MenA family. Type 1 subfamily
HOLAGCBD_00903 0.0 lysS 6.1.1.6 J Belongs to the class-II aminoacyl-tRNA synthetase family
HOLAGCBD_00905 2.4e-212 araJ EGP Major facilitator Superfamily
HOLAGCBD_00906 0.0 S Domain of unknown function (DUF4037)
HOLAGCBD_00907 1.5e-115 S Protein of unknown function (DUF4125)
HOLAGCBD_00908 2.7e-92
HOLAGCBD_00909 5.7e-147 pspC KT PspC domain
HOLAGCBD_00910 6.6e-258 tcsS3 KT PspC domain
HOLAGCBD_00911 5.6e-121 degU K helix_turn_helix, Lux Regulon
HOLAGCBD_00912 3.7e-102 Q Isochorismatase family
HOLAGCBD_00913 2e-269 U Permease for cytosine/purines, uracil, thiamine, allantoin
HOLAGCBD_00914 8.3e-190 yegV G pfkB family carbohydrate kinase
HOLAGCBD_00915 4.6e-188 yegU O ADP-ribosylglycohydrolase
HOLAGCBD_00917 1.2e-247 serS 6.1.1.11 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HOLAGCBD_00918 8.3e-199 I Diacylglycerol kinase catalytic domain
HOLAGCBD_00919 2.8e-157 arbG K CAT RNA binding domain
HOLAGCBD_00920 0.0 crr G pts system, glucose-specific IIABC component
HOLAGCBD_00921 0.0 pgm 5.4.2.2 G Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
HOLAGCBD_00922 8e-151 T LytTr DNA-binding domain
HOLAGCBD_00923 5.7e-250 T GHKL domain
HOLAGCBD_00924 7.3e-212 rnhA 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HOLAGCBD_00925 2.4e-127 rpiA 2.7.1.12, 5.3.1.6 G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HOLAGCBD_00927 2.8e-106
HOLAGCBD_00928 4.1e-251 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HOLAGCBD_00929 1.8e-218 ribF 2.7.1.26, 2.7.7.2 H riboflavin kinase
HOLAGCBD_00930 2.5e-187 truB 5.4.99.25 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HOLAGCBD_00931 2.2e-69 rbfA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HOLAGCBD_00932 0.0 infB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HOLAGCBD_00933 6.1e-191 nusA K Participates in both transcription termination and antitermination
HOLAGCBD_00934 4.7e-104
HOLAGCBD_00936 2e-169 truA 5.4.99.12 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
HOLAGCBD_00937 7.8e-64 rplQ J Ribosomal protein L17
HOLAGCBD_00938 4.7e-185 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HOLAGCBD_00939 1.9e-65 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HOLAGCBD_00940 3.3e-62 rpsM J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HOLAGCBD_00941 8.4e-14 rpmJ J Belongs to the bacterial ribosomal protein bL36 family
HOLAGCBD_00942 1.6e-32 infA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HOLAGCBD_00943 5.5e-98 adk 2.7.4.3 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
HOLAGCBD_00944 9.9e-239 secY U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
HOLAGCBD_00945 9.8e-74 rplO J binds to the 23S rRNA
HOLAGCBD_00946 3.4e-25 rpmD J Ribosomal protein L30p/L7e
HOLAGCBD_00947 1.2e-92 rpsE J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HOLAGCBD_00948 3.3e-59 rplR J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HOLAGCBD_00949 3.8e-96 rplF J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HOLAGCBD_00950 4.6e-67 rpsH J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HOLAGCBD_00951 8.9e-29 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HOLAGCBD_00952 7.5e-103 rplE J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HOLAGCBD_00953 8.7e-51 rplX J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HOLAGCBD_00954 3e-60 rplN J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HOLAGCBD_00955 4.9e-41 rpsQ J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HOLAGCBD_00956 5e-38 rpmC J Belongs to the universal ribosomal protein uL29 family
HOLAGCBD_00957 1.7e-75 rplP J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HOLAGCBD_00958 1e-97 rpsC J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HOLAGCBD_00959 1.9e-56 rplV J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HOLAGCBD_00960 1.3e-47 rpsS J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HOLAGCBD_00961 6.1e-154 rplB J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HOLAGCBD_00962 6.8e-47 rplW J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
HOLAGCBD_00963 1.4e-116 rplD J Forms part of the polypeptide exit tunnel
HOLAGCBD_00964 2.3e-116 rplC J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HOLAGCBD_00965 5.2e-50 rpsJ J Involved in the binding of tRNA to the ribosomes
HOLAGCBD_00966 0.0 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
HOLAGCBD_00967 2.1e-182 rhaR_1 K helix_turn_helix, arabinose operon control protein
HOLAGCBD_00968 4.7e-196 Z012_01000 1.1.1.14, 1.1.1.9 C Zinc-binding dehydrogenase
HOLAGCBD_00969 1.5e-239 EGP Major facilitator Superfamily
HOLAGCBD_00970 1.1e-214 2.7.1.2 GK transcriptional repressor of nag (N-acetylglucosamine) operon K02565
HOLAGCBD_00971 1.4e-76 4.4.1.5 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HOLAGCBD_00972 0.0 glgX 3.2.1.196, 3.2.1.68 CBM48,GH13 G Belongs to the glycosyl hydrolase 13 family
HOLAGCBD_00973 3.4e-67 rpsI J Belongs to the universal ribosomal protein uS9 family
HOLAGCBD_00974 2.4e-80 rplM J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HOLAGCBD_00975 0.0 malQ 2.4.1.18, 2.4.1.25, 3.2.1.196, 5.4.99.15 CBM48,GH13,GH77 G 4-alpha-glucanotransferase
HOLAGCBD_00976 7.9e-110
HOLAGCBD_00977 2.1e-114 yigZ 2.1.1.45, 3.4.13.9 S Uncharacterized protein family UPF0029
HOLAGCBD_00978 9.4e-186 MA20_16500 1.1.1.399, 1.1.1.95 EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HOLAGCBD_00979 4.7e-252 M Bacterial capsule synthesis protein PGA_cap
HOLAGCBD_00980 3.1e-221 dinB 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HOLAGCBD_00982 3.3e-296 CE10 I Belongs to the type-B carboxylesterase lipase family
HOLAGCBD_00983 0.0 G candidate polyfunctional acetylxylan esterase b-xylosidase A-L-arabinofuranosidase, CBM9 module, glycoside hydrolase family 43 protein and carbohydrate esterase family 6 protein K01238
HOLAGCBD_00984 4.1e-233 3.2.1.156 GH8 G CBM9 module, glycoside hydrolase family 8 protein and carbohydrate esterase family 4 protein K01238
HOLAGCBD_00985 0.0 G Psort location Cytoplasmic, score 8.87
HOLAGCBD_00986 0.0 xynB 3.2.1.37 GH43 G Belongs to the glycosyl hydrolase 43 family
HOLAGCBD_00987 2.8e-151 dppF E ABC transporter
HOLAGCBD_00988 6.7e-156 oppD EP Oligopeptide/dipeptide transporter, C-terminal region
HOLAGCBD_00989 3.9e-141 EP Binding-protein-dependent transport system inner membrane component
HOLAGCBD_00990 7.7e-180 EP Binding-protein-dependent transport system inner membrane component
HOLAGCBD_00991 0.0 E Bacterial extracellular solute-binding proteins, family 5 Middle
HOLAGCBD_00993 3.4e-211 dapC E Aminotransferase class I and II
HOLAGCBD_00994 8.3e-59 fdxA C 4Fe-4S binding domain
HOLAGCBD_00995 9.6e-267 E aromatic amino acid transport protein AroP K03293
HOLAGCBD_00996 3.4e-206 murB 1.3.1.98 M Cell wall formation
HOLAGCBD_00997 5.5e-25 rpmG J Ribosomal protein L33
HOLAGCBD_01001 2.5e-46 groS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HOLAGCBD_01002 1.6e-147
HOLAGCBD_01003 3.3e-121 rimJ 2.3.1.128 J Acetyltransferase (GNAT) domain
HOLAGCBD_01004 1.4e-100 fthC 6.3.3.2 H 5-formyltetrahydrofolate cyclo-ligase family
HOLAGCBD_01005 1.3e-29 fmdB S Putative regulatory protein
HOLAGCBD_01006 4.2e-92 flgA NO SAF
HOLAGCBD_01007 7e-35
HOLAGCBD_01008 0.0 L Superfamily I DNA and RNA helicases and helicase subunits
HOLAGCBD_01009 3.6e-175 T Forkhead associated domain
HOLAGCBD_01010 2.4e-36 rplL J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
HOLAGCBD_01011 1.1e-87 rplJ J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HOLAGCBD_01012 1.3e-246 pbuO S Permease family
HOLAGCBD_01013 1.5e-145 P Zinc-uptake complex component A periplasmic
HOLAGCBD_01014 3.6e-148 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
HOLAGCBD_01015 4e-168 pstA P Phosphate transport system permease
HOLAGCBD_01016 1.3e-163 pstC P probably responsible for the translocation of the substrate across the membrane
HOLAGCBD_01017 1e-196 pstS P Part of the ABC transporter complex PstSACB involved in phosphate import
HOLAGCBD_01018 3.4e-129 KT Transcriptional regulatory protein, C terminal
HOLAGCBD_01019 1.1e-219 senX3 2.7.13.3 T His Kinase A (phosphoacceptor) domain
HOLAGCBD_01020 2.8e-123 mtnN 3.2.2.9 E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HOLAGCBD_01021 2.8e-221 aroG 2.5.1.54 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HOLAGCBD_01022 9.7e-211 aroG 2.5.1.54 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HOLAGCBD_01023 4.3e-266 pepC 3.4.22.40 E Peptidase C1-like family
HOLAGCBD_01024 1.3e-58 D nuclear chromosome segregation
HOLAGCBD_01025 3.4e-126 pcp 3.4.19.3 O Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HOLAGCBD_01026 2.5e-144 ispD 1.1.1.405, 2.7.7.40, 2.7.7.60, 4.6.1.12 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)
HOLAGCBD_01027 5.3e-184 yfiH Q Multi-copper polyphenol oxidoreductase laccase
HOLAGCBD_01028 7e-297 yegQ O Peptidase family U32 C-terminal domain
HOLAGCBD_01029 9.7e-171 1.1.1.65 C Oxidoreductase, aldo keto reductase family protein
HOLAGCBD_01030 0.0 S Predicted membrane protein (DUF2207)
HOLAGCBD_01031 1.7e-91 lemA S LemA family
HOLAGCBD_01032 0.0 pnp 2.7.7.8 J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
HOLAGCBD_01033 1.7e-41 rpsO J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HOLAGCBD_01034 1.6e-115
HOLAGCBD_01036 0.0 ams 2.4.1.4, 3.2.1.1, 5.4.99.16 GH13 G Alpha amylase, catalytic domain
HOLAGCBD_01037 1.2e-82 acpS 2.7.8.7, 3.2.1.52 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
HOLAGCBD_01039 0.0 fas 2.3.1.179 I Beta-ketoacyl synthase, C-terminal domain
HOLAGCBD_01040 0.0 pccB I Carboxyl transferase domain
HOLAGCBD_01041 0.0 accA 6.3.4.14, 6.4.1.2, 6.4.1.3 I Carbamoyl-phosphate synthase L chain, ATP binding domain protein
HOLAGCBD_01042 2.1e-79 bioY S BioY family
HOLAGCBD_01043 1e-157 birA 2.7.1.33, 6.3.4.15 H Biotin/lipoate A/B protein ligase family
HOLAGCBD_01044 0.0
HOLAGCBD_01045 5.9e-143 QT PucR C-terminal helix-turn-helix domain
HOLAGCBD_01046 3e-122 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
HOLAGCBD_01047 2.3e-72 rplK J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HOLAGCBD_01048 2.9e-129 nusG K Participates in transcription elongation, termination and antitermination
HOLAGCBD_01049 1.2e-32 secE U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
HOLAGCBD_01051 3.3e-233 aspC E DegT/DnrJ/EryC1/StrS aminotransferase family
HOLAGCBD_01052 1e-204 proB 2.7.2.11 E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HOLAGCBD_01053 2.3e-311 obg S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HOLAGCBD_01054 2.6e-39 rpmA J Ribosomal L27 protein
HOLAGCBD_01055 2.4e-47 rplU J This protein binds to 23S rRNA in the presence of protein L20
HOLAGCBD_01056 2.5e-308 rne 3.1.26.12 J Ribonuclease E/G family
HOLAGCBD_01057 3.1e-231 dapE 3.5.1.18 E Peptidase dimerisation domain
HOLAGCBD_01058 2.7e-166 mdcF S Transporter, auxin efflux carrier (AEC) family protein
HOLAGCBD_01059 2.5e-270 V Efflux ABC transporter, permease protein
HOLAGCBD_01060 5e-128 V ATPases associated with a variety of cellular activities
HOLAGCBD_01061 1.5e-115 rnhB 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HOLAGCBD_01062 6.7e-116 lepB 3.4.21.89 U Belongs to the peptidase S26 family
HOLAGCBD_01063 1.5e-59 rplS J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
HOLAGCBD_01064 0.0 pgi 5.3.1.9 G Belongs to the GPI family
HOLAGCBD_01065 5.4e-181 S Auxin Efflux Carrier
HOLAGCBD_01066 3.9e-131 clcA P Voltage gated chloride channel
HOLAGCBD_01067 2.8e-147 U Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HOLAGCBD_01068 3.3e-57 crcB U Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HOLAGCBD_01069 5.4e-29 E Receptor family ligand binding region
HOLAGCBD_01070 6.5e-196 K helix_turn _helix lactose operon repressor
HOLAGCBD_01071 1.2e-296 gtfA 2.4.1.329, 2.4.1.7 GH13 G Domain of unknown function (DUF1964)
HOLAGCBD_01072 4.9e-10 S Protein of unknown function, DUF624
HOLAGCBD_01073 9e-279 scrT G Transporter major facilitator family protein
HOLAGCBD_01074 7.9e-252 yhjE EGP Sugar (and other) transporter
HOLAGCBD_01075 1.8e-203 ilvC 1.1.1.86 H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HOLAGCBD_01076 4e-203 ilvC 1.1.1.86 H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HOLAGCBD_01077 0.0 3.1.1.53 E Carbohydrate esterase, sialic acid-specific acetylesterase
HOLAGCBD_01078 5.8e-40 G beta-mannosidase
HOLAGCBD_01079 2.1e-188 K helix_turn _helix lactose operon repressor
HOLAGCBD_01080 8.3e-12 S Protein of unknown function, DUF624
HOLAGCBD_01081 5.4e-270 aroP E aromatic amino acid transport protein AroP K03293
HOLAGCBD_01082 0.0 V FtsX-like permease family
HOLAGCBD_01083 3.3e-227 P Sodium/hydrogen exchanger family
HOLAGCBD_01084 5e-79 S Psort location Cytoplasmic, score 8.87
HOLAGCBD_01085 3.1e-176 3.4.22.70 M Sortase family
HOLAGCBD_01086 0.0 inlJ M domain protein
HOLAGCBD_01087 1.1e-252 M domain protein
HOLAGCBD_01088 1.1e-79 S Psort location Cytoplasmic, score 8.87
HOLAGCBD_01089 1.5e-18
HOLAGCBD_01090 9.9e-275 cycA E Amino acid permease
HOLAGCBD_01091 1.2e-166 thiG 2.8.1.10 H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S
HOLAGCBD_01092 3.8e-128 thiF 2.7.7.73, 2.7.7.80 H ThiF family
HOLAGCBD_01093 3.8e-26 thiS 2.8.1.10 H ThiS family
HOLAGCBD_01094 1.4e-179 1.1.1.65 C Aldo/keto reductase family
HOLAGCBD_01095 1.9e-57 ydgJ K helix_turn_helix multiple antibiotic resistance protein
HOLAGCBD_01096 2.1e-285 lmrA1 V ABC transporter, ATP-binding protein
HOLAGCBD_01097 0.0 lmrA2 V ABC transporter transmembrane region
HOLAGCBD_01098 3.4e-122 apbE 2.7.1.180 H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
HOLAGCBD_01099 2e-237 G MFS/sugar transport protein
HOLAGCBD_01100 2.4e-293 efeU_1 P Iron permease FTR1 family
HOLAGCBD_01101 1.4e-92 tpd P Fe2+ transport protein
HOLAGCBD_01102 3.2e-231 S Predicted membrane protein (DUF2318)
HOLAGCBD_01103 8e-220 macB_2 V ABC transporter permease
HOLAGCBD_01105 2.7e-201 Z012_06715 V FtsX-like permease family
HOLAGCBD_01106 2.2e-148 macB V ABC transporter, ATP-binding protein
HOLAGCBD_01107 1.1e-61 S FMN_bind
HOLAGCBD_01108 4.1e-89 K Psort location Cytoplasmic, score 8.87
HOLAGCBD_01109 2.1e-278 pip S YhgE Pip domain protein
HOLAGCBD_01110 0.0 pip S YhgE Pip domain protein
HOLAGCBD_01111 2.4e-226 S Putative ABC-transporter type IV
HOLAGCBD_01112 1.7e-37 nrdH O Glutaredoxin
HOLAGCBD_01115 2.2e-304 pepD E Peptidase family C69
HOLAGCBD_01116 4e-195 XK27_01805 M Glycosyltransferase like family 2
HOLAGCBD_01118 5.1e-109 icaR K Bacterial regulatory proteins, tetR family
HOLAGCBD_01119 3.3e-167 ftsY U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HOLAGCBD_01120 1.2e-236 amt U Ammonium Transporter Family
HOLAGCBD_01121 1e-54 glnB K Nitrogen regulatory protein P-II
HOLAGCBD_01122 0.0 2.7.7.19, 2.7.7.59 O Nucleotidyltransferase domain
HOLAGCBD_01123 3.3e-248 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
HOLAGCBD_01124 6.3e-242 murD 3.4.21.10, 6.3.2.13, 6.3.2.9 M Domain of unknown function (DUF1727)
HOLAGCBD_01125 2.1e-137 cobQ S CobB/CobQ-like glutamine amidotransferase domain
HOLAGCBD_01126 1e-27 S granule-associated protein
HOLAGCBD_01127 0.0 ubiB S ABC1 family
HOLAGCBD_01128 1.4e-192 K Periplasmic binding protein domain
HOLAGCBD_01129 2.5e-242 G Bacterial extracellular solute-binding protein
HOLAGCBD_01130 8.6e-08 P Binding-protein-dependent transport system inner membrane component
HOLAGCBD_01131 3.1e-167 P Binding-protein-dependent transport system inner membrane component
HOLAGCBD_01132 9.3e-147 G Binding-protein-dependent transport system inner membrane component
HOLAGCBD_01133 0.0 3.2.1.185 GH127 S Beta-L-arabinofuranosidase, GH127
HOLAGCBD_01134 0.0 sca1 3.2.1.187 GH121 DG Bacterial Ig-like domain (group 4)
HOLAGCBD_01135 0.0 G Bacterial Ig-like domain (group 4)
HOLAGCBD_01136 1.5e-208 ugpQ 3.1.4.46 C Glycerophosphoryl diester phosphodiesterase family
HOLAGCBD_01137 2.7e-117 upp 2.4.2.9 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HOLAGCBD_01138 2.5e-90
HOLAGCBD_01139 4.5e-224 mutT 3.6.1.13, 3.6.1.55 LT Phosphoglycerate mutase family
HOLAGCBD_01140 0.0 ppk 2.7.4.1 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HOLAGCBD_01142 1.1e-141 cpaE D bacterial-type flagellum organization
HOLAGCBD_01143 5.7e-183 cpaF U Type II IV secretion system protein
HOLAGCBD_01144 8.4e-123 U Type ii secretion system
HOLAGCBD_01145 8.8e-90 gspF NU Type II secretion system (T2SS), protein F
HOLAGCBD_01146 1.3e-42 S Protein of unknown function (DUF4244)
HOLAGCBD_01147 1.1e-59 U TadE-like protein
HOLAGCBD_01148 3e-55 S TIGRFAM helicase secretion neighborhood TadE-like protein
HOLAGCBD_01149 1.6e-216 dagK 2.7.1.107 I Diacylglycerol kinase catalytic domain protein
HOLAGCBD_01150 1.6e-193 S Psort location CytoplasmicMembrane, score
HOLAGCBD_01151 1.1e-96 K Bacterial regulatory proteins, tetR family
HOLAGCBD_01152 0.0 dnaX 2.7.7.7 L DNA polymerase III subunit gamma tau
HOLAGCBD_01153 2.2e-105 recR L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HOLAGCBD_01154 3.4e-135 ask 1.1.1.3, 2.7.2.4 E Amino acid kinase family
HOLAGCBD_01155 1.4e-96 askB 1.1.1.3, 2.7.2.4 E ACT domain
HOLAGCBD_01156 7.2e-211 asd 1.2.1.11, 1.2.1.12 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HOLAGCBD_01157 2.7e-48 yitI S Acetyltransferase (GNAT) domain
HOLAGCBD_01158 9.3e-115
HOLAGCBD_01159 1.4e-300 S Calcineurin-like phosphoesterase
HOLAGCBD_01160 0.0 leuA 2.3.3.13 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HOLAGCBD_01161 0.0 3.2.1.99 GH43 G C-terminal of Glycosyl hydrolases family 43
HOLAGCBD_01162 0.0 3.2.1.99 GH43 G C-terminal of Glycosyl hydrolases family 43
HOLAGCBD_01163 0.0 3.2.1.97 GH101 G Glycosyl hydrolases family 43
HOLAGCBD_01164 9.2e-195 K helix_turn _helix lactose operon repressor
HOLAGCBD_01165 6e-204 abf G Glycosyl hydrolases family 43
HOLAGCBD_01166 8.2e-246 G Bacterial extracellular solute-binding protein
HOLAGCBD_01167 9.1e-170 G Binding-protein-dependent transport system inner membrane component
HOLAGCBD_01168 1.9e-156 U Binding-protein-dependent transport system inner membrane component
HOLAGCBD_01169 0.0 S Beta-L-arabinofuranosidase, GH127
HOLAGCBD_01170 0.0 mrcB 2.4.1.129, 3.4.16.4 GT51 M Transglycosylase
HOLAGCBD_01171 7.7e-216 ino1 5.5.1.4 I Myo-inositol-1-phosphate synthase
HOLAGCBD_01172 8.5e-234 glf 5.4.99.9 M UDP-galactopyranose mutase
HOLAGCBD_01173 6.2e-191 3.6.1.27 I PAP2 superfamily
HOLAGCBD_01174 0.0 topA 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HOLAGCBD_01175 1.2e-107 tmk 2.7.4.9 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HOLAGCBD_01176 3.9e-191 holB 2.7.7.7 L DNA polymerase III
HOLAGCBD_01177 5.4e-184 K helix_turn _helix lactose operon repressor
HOLAGCBD_01178 6e-39 ptsH G PTS HPr component phosphorylation site
HOLAGCBD_01179 1e-285 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HOLAGCBD_01180 2.4e-106 S Phosphatidylethanolamine-binding protein
HOLAGCBD_01181 0.0 pepD E Peptidase family C69
HOLAGCBD_01182 9.1e-289 fhs 1.5.1.5, 3.5.4.9, 6.3.4.3 F Formate-tetrahydrofolate ligase
HOLAGCBD_01183 6.7e-62 S Macrophage migration inhibitory factor (MIF)
HOLAGCBD_01184 7.1e-95 S GtrA-like protein
HOLAGCBD_01185 2.1e-263 EGP Major facilitator Superfamily
HOLAGCBD_01186 1.5e-123 3.1.3.3, 3.1.3.73 G Phosphoglycerate mutase family
HOLAGCBD_01187 7e-184
HOLAGCBD_01188 8.5e-97 S Protein of unknown function (DUF805)
HOLAGCBD_01189 5.5e-297 gltX 6.1.1.17 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HOLAGCBD_01192 4.1e-265 S Calcineurin-like phosphoesterase
HOLAGCBD_01193 1.1e-139 ltbR K Transcriptional regulator, IclR family, C-terminal domain protein
HOLAGCBD_01194 7.1e-272 leuC 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HOLAGCBD_01195 1.3e-131 leuD 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HOLAGCBD_01196 3.6e-200 pyrD 1.3.1.14, 1.3.98.1 F Dihydroorotate dehydrogenase
HOLAGCBD_01197 1e-256 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HOLAGCBD_01198 5.5e-177 plsC2 2.3.1.51 I Phosphate acyltransferases
HOLAGCBD_01199 1.7e-179 gpsA 1.1.1.94 I NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus
HOLAGCBD_01200 3.7e-218 ddl 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
HOLAGCBD_01201 4e-177 S CAAX protease self-immunity
HOLAGCBD_01202 1.7e-137 M Mechanosensitive ion channel
HOLAGCBD_01203 3.8e-229 MA20_36090 S Psort location Cytoplasmic, score 8.87
HOLAGCBD_01204 2.4e-228 MA20_36090 S Psort location Cytoplasmic, score 8.87
HOLAGCBD_01205 8.2e-125 K Bacterial regulatory proteins, tetR family
HOLAGCBD_01206 5.2e-231 yhdR 2.6.1.1 E Psort location Cytoplasmic, score 8.87
HOLAGCBD_01207 5.2e-167 gnd 1.1.1.343, 1.1.1.44 G 6-phosphogluconate dehydrogenase, C-terminal domain
HOLAGCBD_01209 1.3e-227 gnuT EG GntP family permease
HOLAGCBD_01210 2.8e-83 gntK 2.7.1.12 F Shikimate kinase
HOLAGCBD_01211 1.9e-127 gntR K FCD
HOLAGCBD_01212 3e-227 yxiO S Vacuole effluxer Atg22 like
HOLAGCBD_01213 0.0 S Psort location Cytoplasmic, score 8.87
HOLAGCBD_01214 8.4e-30 rpmB J Ribosomal L28 family
HOLAGCBD_01215 0.0 recG 3.6.4.12 L helicase superfamily c-terminal domain
HOLAGCBD_01216 6.5e-105 rsmD 2.1.1.171 L Conserved hypothetical protein 95
HOLAGCBD_01217 2.3e-150 trmD 2.1.1.228, 4.6.1.12 J Belongs to the RNA methyltransferase TrmD family
HOLAGCBD_01218 3.6e-108 rimM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HOLAGCBD_01219 1.8e-34 CP_0960 S Belongs to the UPF0109 family
HOLAGCBD_01220 3.9e-54 rpsP J Belongs to the bacterial ribosomal protein bS16 family
HOLAGCBD_01221 2e-178 S Endonuclease/Exonuclease/phosphatase family
HOLAGCBD_01222 2.7e-270 ffh 3.6.5.4 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HOLAGCBD_01224 1.6e-94
HOLAGCBD_01225 2.1e-302 cysS 6.1.1.16 J Belongs to the class-I aminoacyl-tRNA synthetase family
HOLAGCBD_01226 7.3e-152 guaA1 6.3.5.2 F Peptidase C26
HOLAGCBD_01227 0.0 yjjK S ABC transporter
HOLAGCBD_01228 6.7e-93
HOLAGCBD_01230 5.7e-92 ilvN 2.2.1.6 E ACT domain
HOLAGCBD_01231 0.0 ilvB 2.2.1.6 H Thiamine pyrophosphate enzyme, central domain
HOLAGCBD_01232 5.7e-136 rnc 3.1.26.3 J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
HOLAGCBD_01233 1e-19 rpmF J Belongs to the bacterial ribosomal protein bL32 family
HOLAGCBD_01234 1.8e-113 yceD S Uncharacterized ACR, COG1399
HOLAGCBD_01235 8.5e-134
HOLAGCBD_01236 1.7e-87 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HOLAGCBD_01237 9.4e-58 S Protein of unknown function (DUF3039)
HOLAGCBD_01238 8.7e-195 yghZ C Aldo/keto reductase family
HOLAGCBD_01239 5.4e-77 soxR K MerR, DNA binding
HOLAGCBD_01240 3.6e-120 rdgB 3.6.1.66, 5.1.1.3 F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HOLAGCBD_01241 3.9e-139 rph 2.7.7.56, 3.6.1.66 J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HOLAGCBD_01242 1.1e-250 pncB 6.3.4.21 F Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HOLAGCBD_01243 1.1e-236 murN 2.3.2.16 V Psort location Cytoplasmic, score 8.87
HOLAGCBD_01244 4.2e-218 murN 2.3.2.16 V Psort location Cytoplasmic, score 8.87
HOLAGCBD_01247 0.0 lacZ5 3.2.1.23 G Psort location Cytoplasmic, score 8.87
HOLAGCBD_01248 0.0 abfA1 3.2.1.55 GH51 G arabinose metabolic process
HOLAGCBD_01249 2.2e-246 G Bacterial extracellular solute-binding protein
HOLAGCBD_01250 1.8e-275 G Bacterial extracellular solute-binding protein
HOLAGCBD_01251 4.8e-122 K Transcriptional regulatory protein, C terminal
HOLAGCBD_01252 1.2e-143 T His Kinase A (phosphoacceptor) domain
HOLAGCBD_01253 7e-82 S SnoaL-like domain
HOLAGCBD_01254 2e-143 coaX 2.7.1.33 H Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HOLAGCBD_01255 3e-240 coaBC 4.1.1.36, 6.3.2.5 H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HOLAGCBD_01256 1.6e-291 E ABC transporter, substrate-binding protein, family 5
HOLAGCBD_01257 1.2e-164 P Binding-protein-dependent transport system inner membrane component
HOLAGCBD_01258 1.2e-139 EP Binding-protein-dependent transport system inner membrane component
HOLAGCBD_01259 1.4e-136 oppD EP oligopeptide transport protein of the ABC superfamily, ATP-binding component
HOLAGCBD_01260 5.2e-139 sapF E ATPases associated with a variety of cellular activities
HOLAGCBD_01261 9.9e-191 cbs 2.5.1.47, 4.2.1.22 E Pyridoxal-phosphate dependent enzyme
HOLAGCBD_01262 2.2e-218 metB 2.5.1.48, 4.4.1.1, 4.4.1.8 E Cys/Met metabolism PLP-dependent enzyme
HOLAGCBD_01263 0.0 macB_2 V ATPases associated with a variety of cellular activities
HOLAGCBD_01264 0.0 recQ 3.6.4.12 L ATP-dependent DNA helicase RecQ
HOLAGCBD_01265 3.9e-92 luxS 4.4.1.21 H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
HOLAGCBD_01266 2.7e-102 cysE 2.3.1.178 J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HOLAGCBD_01267 1.5e-269 yhdG E aromatic amino acid transport protein AroP K03293
HOLAGCBD_01268 2e-307 alr 5.1.1.1 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HOLAGCBD_01269 0.0 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
HOLAGCBD_01270 2e-214 ybiR P Citrate transporter
HOLAGCBD_01272 7.5e-175 ydcZ S Putative inner membrane exporter, YdcZ
HOLAGCBD_01274 0.0 tetP J Elongation factor G, domain IV
HOLAGCBD_01278 3.5e-101 K acetyltransferase
HOLAGCBD_01279 1.1e-108 papP E Binding-protein-dependent transport system inner membrane component
HOLAGCBD_01280 3.6e-120 E Binding-protein-dependent transport system inner membrane component
HOLAGCBD_01281 5.8e-152 glnQ 3.6.3.21 E ATP binding protein of ABC transporter for glutamate aspartate K02028
HOLAGCBD_01282 3.8e-141 cjaA ET Bacterial periplasmic substrate-binding proteins
HOLAGCBD_01283 9.1e-200 panE1 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HOLAGCBD_01284 7.6e-155 metQ M NLPA lipoprotein
HOLAGCBD_01285 4.2e-192 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HOLAGCBD_01286 4.9e-98 metI P Psort location CytoplasmicMembrane, score 9.99
HOLAGCBD_01287 2.6e-219 mtnE 2.6.1.83 E Aminotransferase class I and II
HOLAGCBD_01288 3.2e-75 metC 2.5.1.48, 4.4.1.8 E Cys/Met metabolism PLP-dependent enzyme
HOLAGCBD_01289 1.4e-43 XAC3035 O Glutaredoxin
HOLAGCBD_01290 3.1e-127 XK27_08050 O prohibitin homologues
HOLAGCBD_01291 1.3e-74
HOLAGCBD_01292 1.4e-133 V ATPases associated with a variety of cellular activities
HOLAGCBD_01293 2.8e-146 M Conserved repeat domain
HOLAGCBD_01294 6.8e-257 macB_8 V MacB-like periplasmic core domain
HOLAGCBD_01295 0.0 dxs 2.2.1.7 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HOLAGCBD_01296 1.2e-183 adh3 C Zinc-binding dehydrogenase
HOLAGCBD_01297 1.1e-84 purE 5.4.99.18 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HOLAGCBD_01298 7.1e-225 purK 6.3.4.18 F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HOLAGCBD_01299 2.6e-88 zur P Belongs to the Fur family
HOLAGCBD_01300 0.0 XK27_08315 M Psort location CytoplasmicMembrane, score 9.26
HOLAGCBD_01301 4.7e-202 psuK 2.7.1.15, 2.7.1.45, 2.7.1.83 G pfkB family carbohydrate kinase
HOLAGCBD_01302 4.5e-188 yeiI 2.7.1.15, 2.7.1.45, 2.7.1.83 G pfkB family carbohydrate kinase
HOLAGCBD_01303 3.3e-129 trpF 5.3.1.24 E N-(5'phosphoribosyl)anthranilate (PRA) isomerase
HOLAGCBD_01304 2.1e-213 1.1.1.1 C Iron-containing alcohol dehydrogenase
HOLAGCBD_01305 1.1e-183 rihB 3.2.2.1 F Inosine-uridine preferring nucleoside hydrolase
HOLAGCBD_01306 2.1e-247 EGP Major facilitator Superfamily
HOLAGCBD_01307 2.8e-235 purD 6.3.4.13 F Belongs to the GARS family
HOLAGCBD_01308 8.3e-185 purM 6.3.3.1, 6.3.4.13 F Phosphoribosylformylglycinamidine cyclo-ligase
HOLAGCBD_01309 1e-284 purF 2.4.2.14 F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HOLAGCBD_01310 8e-307 umuC 2.7.7.7 L DNA-damage repair protein (DNA polymerase IV) K00961
HOLAGCBD_01311 1.5e-33
HOLAGCBD_01312 0.0 purL 6.3.5.3 F CobB/CobQ-like glutamine amidotransferase domain
HOLAGCBD_01313 4.3e-138 purC 4.1.1.21, 4.3.2.2, 6.3.2.6 F Belongs to the SAICAR synthetase family
HOLAGCBD_01314 4.3e-228 purT 2.1.2.2 F Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HOLAGCBD_01315 6.5e-226 M Glycosyl transferase 4-like domain
HOLAGCBD_01316 2.9e-198 ltaE 4.1.2.48 E Beta-eliminating lyase
HOLAGCBD_01318 1.8e-187 yocS S SBF-like CPA transporter family (DUF4137)
HOLAGCBD_01320 1.2e-61 rpsL J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HOLAGCBD_01321 3.3e-80 rpsG J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
HOLAGCBD_01322 0.0 fusA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HOLAGCBD_01323 9.5e-233 tuf J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HOLAGCBD_01324 2e-103 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HOLAGCBD_01325 1.8e-75 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HOLAGCBD_01326 1.1e-239 carA 6.3.5.5 F Belongs to the CarA family
HOLAGCBD_01327 0.0 carB 6.3.5.5 EF Carbamoyl-phosphate synthetase large chain, oligomerisation domain
HOLAGCBD_01328 7.6e-169 pyrF 2.4.2.10, 4.1.1.23 F Essential for recycling GMP and indirectly, cGMP
HOLAGCBD_01329 9.1e-104 gmk 2.7.4.8, 4.1.1.23 F Essential for recycling GMP and indirectly, cGMP
HOLAGCBD_01331 0.0 ilvD 4.2.1.9 H Belongs to the IlvD Edd family
HOLAGCBD_01332 1.4e-46 rpoZ 2.7.7.6 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
HOLAGCBD_01333 4.2e-228 metK 2.5.1.6 H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HOLAGCBD_01334 0.0 priA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HOLAGCBD_01335 2.7e-134 3.8.1.2 S Haloacid dehalogenase-like hydrolase
HOLAGCBD_01336 1.1e-178 fmt 2.1.1.176, 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HOLAGCBD_01337 3.5e-123 serB 3.1.3.3 E haloacid dehalogenase-like hydrolase
HOLAGCBD_01338 1.3e-282 arc O AAA ATPase forming ring-shaped complexes
HOLAGCBD_01339 1.6e-302 dop 3.5.1.119, 6.3.1.19 S Pup-ligase protein
HOLAGCBD_01340 3.3e-160 hisN 3.1.3.25 G Inositol monophosphatase family
HOLAGCBD_01341 1.4e-24 pup S Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation
HOLAGCBD_01342 2.6e-280 pafA 6.3.1.19 O Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HOLAGCBD_01343 9.7e-141 C FMN binding
HOLAGCBD_01344 1.8e-57
HOLAGCBD_01345 1.4e-41 hup L Belongs to the bacterial histone-like protein family
HOLAGCBD_01346 0.0 S Lysylphosphatidylglycerol synthase TM region
HOLAGCBD_01347 1.6e-279 purB 4.3.2.2 F Adenylosuccinate lyase C-terminal
HOLAGCBD_01348 1.6e-277 S PGAP1-like protein
HOLAGCBD_01349 3.2e-61
HOLAGCBD_01350 2.7e-180 S von Willebrand factor (vWF) type A domain
HOLAGCBD_01351 4.7e-191 S von Willebrand factor (vWF) type A domain
HOLAGCBD_01352 3.6e-91
HOLAGCBD_01353 5.5e-175 S Protein of unknown function DUF58
HOLAGCBD_01354 4e-182 moxR S ATPase family associated with various cellular activities (AAA)
HOLAGCBD_01355 4.4e-137 ung 3.2.2.27 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HOLAGCBD_01356 8.5e-77 S LytR cell envelope-related transcriptional attenuator
HOLAGCBD_01357 8.7e-290 groL O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
HOLAGCBD_01359 1.3e-124
HOLAGCBD_01360 6.8e-133 KT Response regulator receiver domain protein
HOLAGCBD_01361 0.0 2.7.13.3 T ATPase histidine kinase DNA gyrase B HSP90 domain protein
HOLAGCBD_01362 4.5e-67 cspB K 'Cold-shock' DNA-binding domain
HOLAGCBD_01363 1.2e-182 S Protein of unknown function (DUF3027)
HOLAGCBD_01364 4.6e-188 uspA T Belongs to the universal stress protein A family
HOLAGCBD_01365 0.0 clpC O ATPase family associated with various cellular activities (AAA)
HOLAGCBD_01366 4.1e-253 codA 3.5.4.1, 3.5.4.21 F Amidohydrolase family
HOLAGCBD_01367 1.4e-284 purR QT Purine catabolism regulatory protein-like family
HOLAGCBD_01368 5.5e-245 proP EGP Sugar (and other) transporter
HOLAGCBD_01369 1.6e-140 3.5.2.10 S Creatinine amidohydrolase
HOLAGCBD_01370 1.5e-216 3.1.26.12, 3.2.1.8 S Domain of Unknown Function (DUF349)
HOLAGCBD_01371 5.3e-251 hisS 6.1.1.21 J Histidyl-tRNA synthetase
HOLAGCBD_01372 0.0 aspS 6.1.1.12 J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HOLAGCBD_01373 7.1e-281 glnP E Binding-protein-dependent transport system inner membrane component
HOLAGCBD_01374 2.8e-137 glnQ 3.6.3.21 E ATPases associated with a variety of cellular activities
HOLAGCBD_01375 1.4e-136 gluA 3.6.3.21 E ATP-binding protein of ABC transporter for glutamate K02028
HOLAGCBD_01376 1.4e-153 gluB ET Belongs to the bacterial solute-binding protein 3 family
HOLAGCBD_01377 3.1e-111 gluC E Binding-protein-dependent transport system inner membrane component
HOLAGCBD_01378 1.7e-199 gluD E Binding-protein-dependent transport system inner membrane component
HOLAGCBD_01379 4.3e-191 2.7.4.1 S Polyphosphate kinase 2 (PPK2)
HOLAGCBD_01380 0.0 L DEAD DEAH box helicase
HOLAGCBD_01381 2.4e-251 rarA L Recombination factor protein RarA
HOLAGCBD_01382 2.9e-258 EGP Major facilitator Superfamily
HOLAGCBD_01383 9.2e-311 E ABC transporter, substrate-binding protein, family 5
HOLAGCBD_01384 1e-113 clpP 3.4.21.92 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
HOLAGCBD_01385 8.6e-125 clpP 3.4.21.92 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
HOLAGCBD_01386 6.1e-241 clpX O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HOLAGCBD_01389 3.6e-244 nhaA P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HOLAGCBD_01390 4.8e-117 safC S O-methyltransferase
HOLAGCBD_01391 5.2e-178 sdhB 1.3.5.1, 1.3.5.4 C 4Fe-4S dicluster domain
HOLAGCBD_01392 0.0 sdhA 1.3.5.1, 1.3.5.4 C Succinate dehydrogenase flavoprotein subunit
HOLAGCBD_01393 5.9e-255 dprA 5.99.1.2 LU DNA recombination-mediator protein A
HOLAGCBD_01394 1e-292 comM O Magnesium chelatase, subunit ChlI C-terminal
HOLAGCBD_01395 1.5e-82 yraN L Belongs to the UPF0102 family
HOLAGCBD_01396 1.5e-166 pdxK 2.7.1.35 H Phosphomethylpyrimidine kinase
HOLAGCBD_01397 5.9e-252 metY 2.5.1.49 E Aminotransferase class-V
HOLAGCBD_01398 4.3e-95 XK27_01265 S ECF-type riboflavin transporter, S component
HOLAGCBD_01399 2.5e-305 3.6.3.24 P AAA domain, putative AbiEii toxin, Type IV TA system
HOLAGCBD_01400 2e-149 P Cobalt transport protein
HOLAGCBD_01401 8.2e-193 K helix_turn_helix ASNC type
HOLAGCBD_01402 9.6e-141 V ABC transporter, ATP-binding protein
HOLAGCBD_01403 0.0 MV MacB-like periplasmic core domain
HOLAGCBD_01404 1.1e-125 K helix_turn_helix, Lux Regulon
HOLAGCBD_01405 0.0 tcsS2 T Histidine kinase
HOLAGCBD_01406 1.5e-266 pip 3.4.11.5 S alpha/beta hydrolase fold
HOLAGCBD_01407 7.7e-138 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HOLAGCBD_01408 3.9e-201 ychF J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
HOLAGCBD_01409 2.5e-239 S HipA-like C-terminal domain
HOLAGCBD_01410 1.6e-16 K addiction module antidote protein HigA
HOLAGCBD_01411 3e-213 G Transmembrane secretion effector
HOLAGCBD_01412 1.2e-118 K Bacterial regulatory proteins, tetR family
HOLAGCBD_01413 8e-58 yccF S Inner membrane component domain
HOLAGCBD_01414 1e-11
HOLAGCBD_01415 1e-42 cysB 4.2.1.22 EGP Major facilitator Superfamily
HOLAGCBD_01416 3.7e-132 cysB 4.2.1.22 EGP Major facilitator Superfamily
HOLAGCBD_01417 0.0 bga1 3.2.1.23 G Psort location Cytoplasmic, score 8.87
HOLAGCBD_01418 1.1e-195 K helix_turn _helix lactose operon repressor
HOLAGCBD_01419 2.1e-241 mntH P H( )-stimulated, divalent metal cation uptake system
HOLAGCBD_01420 9.3e-166 dkgA 1.1.1.346 S Oxidoreductase, aldo keto reductase family protein
HOLAGCBD_01421 6.2e-127 L Protein of unknown function (DUF1524)
HOLAGCBD_01422 3.1e-174 T Diguanylate cyclase (GGDEF) domain protein
HOLAGCBD_01423 7.6e-283 EGP Major facilitator Superfamily
HOLAGCBD_01424 1.3e-46
HOLAGCBD_01425 2.7e-180 S Endonuclease/Exonuclease/phosphatase family
HOLAGCBD_01426 1.4e-86 3.1.3.48 T Low molecular weight phosphatase family
HOLAGCBD_01427 2.5e-224 pflA S Protein of unknown function (DUF4012)
HOLAGCBD_01428 7.9e-189 wcoI DM Psort location CytoplasmicMembrane, score
HOLAGCBD_01429 2.2e-14
HOLAGCBD_01430 3.4e-103
HOLAGCBD_01431 2.7e-40 L Integrase core domain
HOLAGCBD_01432 8.7e-231 M Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
HOLAGCBD_01433 4.4e-179 M Domain of unknown function (DUF1972)
HOLAGCBD_01434 3.5e-162 lspL 5.1.3.6 M epimerase dehydratase
HOLAGCBD_01435 2.6e-201 1.1.1.22 M UDP binding domain
HOLAGCBD_01436 3.2e-62 M Glycosyl transferases group 1
HOLAGCBD_01437 1.2e-109 1.1.1.339 GM GDP-mannose 4,6 dehydratase
HOLAGCBD_01438 6.8e-14 S Psort location CytoplasmicMembrane, score 10.00
HOLAGCBD_01439 1.6e-33 GT8 S Protein conserved in bacteria
HOLAGCBD_01440 5.5e-121 cps4J S Polysaccharide biosynthesis protein
HOLAGCBD_01441 3.8e-40 maa 2.3.1.79 S Bacterial transferase hexapeptide (six repeats)
HOLAGCBD_01442 1.5e-186 M Glycosyl transferase 4-like domain
HOLAGCBD_01443 3.3e-29 GM Bacterial transferase hexapeptide (six repeats)
HOLAGCBD_01444 4.5e-115 wbiB 5.1.3.25 GM 3-beta hydroxysteroid dehydrogenase/isomerase family
HOLAGCBD_01445 6.5e-187 rfbB 4.2.1.46 M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
HOLAGCBD_01446 5.1e-257 rmlC 1.1.1.133, 5.1.3.13 M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
HOLAGCBD_01447 3.9e-170 rfbA 2.7.7.24 H Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HOLAGCBD_01448 2.7e-39 S Bacteriophage abortive infection AbiH
HOLAGCBD_01449 4.3e-167 L Transposase and inactivated derivatives IS30 family
HOLAGCBD_01451 5.1e-84 K Helix-turn-helix domain protein
HOLAGCBD_01452 1.7e-26 tnp7109-21 L Integrase core domain
HOLAGCBD_01453 1.1e-29 S Abi-like protein
HOLAGCBD_01454 1.2e-60 L Helix-turn-helix domain
HOLAGCBD_01455 6.7e-119 insK L Integrase core domain
HOLAGCBD_01456 1.2e-25 K Transposase IS116 IS110 IS902
HOLAGCBD_01458 1.9e-09
HOLAGCBD_01459 2.3e-35
HOLAGCBD_01461 2.5e-29 S AAA domain, putative AbiEii toxin, Type IV TA system
HOLAGCBD_01463 8.2e-115 ysdA S Protein of unknown function (DUF1294)
HOLAGCBD_01464 4.2e-243 S Psort location CytoplasmicMembrane, score 9.99
HOLAGCBD_01465 1.3e-150 V Abi-like protein
HOLAGCBD_01467 2.4e-54 yccF S Inner membrane component domain
HOLAGCBD_01468 8.3e-15 wcoI DM Psort location CytoplasmicMembrane, score
HOLAGCBD_01469 1.8e-184 K Psort location Cytoplasmic, score
HOLAGCBD_01470 1.1e-269 G Bacterial extracellular solute-binding protein
HOLAGCBD_01471 1.7e-162 P Binding-protein-dependent transport system inner membrane component
HOLAGCBD_01472 6.5e-148 P Binding-protein-dependent transport system inner membrane component
HOLAGCBD_01473 0.0 3.2.1.20 GH31 G Belongs to the glycosyl hydrolase 31 family
HOLAGCBD_01474 1.7e-264 rfbP M Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
HOLAGCBD_01476 7.8e-88
HOLAGCBD_01477 5.6e-170 S G5
HOLAGCBD_01478 6e-61 trxA 1.8.1.8, 1.8.1.9 O Belongs to the thioredoxin family
HOLAGCBD_01479 1.7e-113 F Domain of unknown function (DUF4916)
HOLAGCBD_01480 3.1e-153 mhpC I Alpha/beta hydrolase family
HOLAGCBD_01481 3e-209 nudC 1.3.7.1, 3.6.1.22 L NADH pyrophosphatase zinc ribbon domain
HOLAGCBD_01482 2.7e-70 gcvH E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein
HOLAGCBD_01483 3.3e-236 S Uncharacterized conserved protein (DUF2183)
HOLAGCBD_01484 0.0 ptrB 3.4.21.83 E Peptidase, S9A B C family, catalytic domain protein
HOLAGCBD_01485 8.4e-193 leuB 1.1.1.85 CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
HOLAGCBD_01486 7.1e-85 J TM2 domain
HOLAGCBD_01487 1.3e-210 lplA 6.3.1.20 H Biotin/lipoate A/B protein ligase family
HOLAGCBD_01488 2.3e-133 glxR K helix_turn_helix, cAMP Regulatory protein
HOLAGCBD_01489 0.0 pon1 2.4.1.129, 3.4.16.4 GT51 M Transglycosylase
HOLAGCBD_01490 3.9e-220 namA 1.6.99.1 C NADH:flavin oxidoreductase / NADH oxidase family
HOLAGCBD_01491 4.2e-222 pyrD 1.3.1.14, 1.3.5.2, 1.3.98.1 F Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor
HOLAGCBD_01492 3.4e-141 glpR K DeoR C terminal sensor domain
HOLAGCBD_01493 4e-250 galT 2.7.7.12 C Galactose-1-phosphate uridyl transferase, N-terminal domain
HOLAGCBD_01494 9e-234 galK 2.7.1.6, 2.7.7.12 G Belongs to the GHMP kinase family. GalK subfamily
HOLAGCBD_01495 2.2e-309 G Bacterial extracellular solute-binding protein
HOLAGCBD_01496 1.6e-177 G Binding-protein-dependent transport system inner membrane component
HOLAGCBD_01497 3.4e-169 G Binding-protein-dependent transport system inner membrane component
HOLAGCBD_01498 3.5e-115 S Protein of unknown function, DUF624
HOLAGCBD_01499 4.7e-178 K helix_turn _helix lactose operon repressor
HOLAGCBD_01500 0.0 cscA 3.2.1.26 GH32 G Belongs to the glycosyl hydrolase 32 family
HOLAGCBD_01501 7.1e-43 gcvR T Belongs to the UPF0237 family
HOLAGCBD_01502 4.7e-252 S UPF0210 protein
HOLAGCBD_01503 3.3e-126 trmL 2.1.1.207 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
HOLAGCBD_01504 9.3e-183 mutY 2.1.1.37, 2.1.3.15, 6.4.1.2 L FES
HOLAGCBD_01505 1.5e-99
HOLAGCBD_01506 0.0 rpoB 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HOLAGCBD_01507 0.0 rpoC 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HOLAGCBD_01508 1.1e-101 T Forkhead associated domain
HOLAGCBD_01509 4.8e-104 B Belongs to the OprB family
HOLAGCBD_01510 4.4e-163 3.1.3.16 T Sigma factor PP2C-like phosphatases
HOLAGCBD_01511 0.0 E Transglutaminase-like superfamily
HOLAGCBD_01512 8.3e-221 S Protein of unknown function DUF58
HOLAGCBD_01513 1.2e-226 S ATPase family associated with various cellular activities (AAA)
HOLAGCBD_01514 0.0 S Fibronectin type 3 domain
HOLAGCBD_01515 6.4e-268 KLT Protein tyrosine kinase
HOLAGCBD_01516 0.0 uvrD 3.6.4.12 L PD-(D/E)XK nuclease superfamily
HOLAGCBD_01517 0.0 uvrD2 3.6.4.12 L Belongs to the helicase family. UvrD subfamily
HOLAGCBD_01518 6.6e-246 G Major Facilitator Superfamily
HOLAGCBD_01519 1.4e-133 dapB 1.17.1.8 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
HOLAGCBD_01520 5.7e-38 csoR S Metal-sensitive transcriptional repressor
HOLAGCBD_01521 0.0 pacS 3.6.3.54 P E1-E2 ATPase
HOLAGCBD_01522 9.5e-175 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HOLAGCBD_01523 0.0 rnj J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HOLAGCBD_01524 0.0 pepN 3.4.11.2 E Peptidase family M1 domain
HOLAGCBD_01525 1e-254 glmM 5.4.2.10 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HOLAGCBD_01526 5.2e-116 def 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
HOLAGCBD_01527 1.5e-289 recE 2.7.7.7, 3.6.4.12 L Psort location Cytoplasmic, score
HOLAGCBD_01528 1.7e-10
HOLAGCBD_01529 9.1e-240 G Bacterial extracellular solute-binding protein
HOLAGCBD_01530 2.1e-129 pdxT 4.3.3.6 H Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HOLAGCBD_01531 4e-156 pdxS 4.3.3.6 H Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HOLAGCBD_01532 0.0 cydD V ABC transporter transmembrane region
HOLAGCBD_01533 0.0 fadD 6.2.1.3 I AMP-binding enzyme
HOLAGCBD_01534 1.8e-297 araA 5.3.1.4 G Catalyzes the conversion of L-arabinose to L-ribulose
HOLAGCBD_01535 1e-130 araD 4.1.2.17, 5.1.3.4 G Class II Aldolase and Adducin N-terminal domain
HOLAGCBD_01536 0.0 araB 2.7.1.16, 2.7.1.17 G FGGY family of carbohydrate kinases, C-terminal domain
HOLAGCBD_01537 2.1e-210 K helix_turn _helix lactose operon repressor
HOLAGCBD_01538 2e-285 maf 1.1.1.25, 2.1.1.190, 3.6.1.55, 3.6.1.67 DF Maf-like protein
HOLAGCBD_01539 1.4e-189 thrB 2.7.1.39 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
HOLAGCBD_01540 1.6e-241 hom 1.1.1.3 E Homoserine dehydrogenase
HOLAGCBD_01541 2e-299 lysA 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
HOLAGCBD_01542 0.0 argS 6.1.1.19 J Arginyl-tRNA synthetase
HOLAGCBD_01543 5.7e-272 mmuP E amino acid
HOLAGCBD_01544 8e-64 psp1 3.5.99.10 J Endoribonuclease L-PSP
HOLAGCBD_01546 1.8e-121 cyaA 4.6.1.1 S CYTH
HOLAGCBD_01547 9.3e-170 trxA2 O Tetratricopeptide repeat
HOLAGCBD_01548 3.3e-178
HOLAGCBD_01549 1.1e-194
HOLAGCBD_01550 6.8e-149 fkbB 5.2.1.8 M FKBP-type peptidyl-prolyl cis-trans isomerase
HOLAGCBD_01551 2.3e-122 nucS L Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HOLAGCBD_01552 2.3e-44 atpC C Produces ATP from ADP in the presence of a proton gradient across the membrane
HOLAGCBD_01553 5.6e-283 atpD 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HOLAGCBD_01554 2.1e-163 atpG C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HOLAGCBD_01555 3.8e-309 atpA 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HOLAGCBD_01556 1.3e-148 atpH C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HOLAGCBD_01557 4.4e-57 atpF C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HOLAGCBD_01558 8.9e-31 atpE C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HOLAGCBD_01559 2e-146 atpB C it plays a direct role in the translocation of protons across the membrane
HOLAGCBD_01560 1.3e-206 metAA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HOLAGCBD_01562 1.4e-272 frc 2.8.3.16 C Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate
HOLAGCBD_01563 3.9e-193 yfdV S Membrane transport protein
HOLAGCBD_01564 0.0 oxc 4.1.1.8 EH Thiamine pyrophosphate enzyme, central domain
HOLAGCBD_01565 3.5e-174 M LPXTG-motif cell wall anchor domain protein
HOLAGCBD_01566 0.0 glgE 2.4.99.16 GH13 G Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB
HOLAGCBD_01567 3.4e-91 ppa 3.6.1.1 C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HOLAGCBD_01568 9.4e-98 mntP P Probably functions as a manganese efflux pump
HOLAGCBD_01569 6.4e-134
HOLAGCBD_01570 6.4e-134 KT Transcriptional regulatory protein, C terminal
HOLAGCBD_01571 3.2e-123 nth 4.2.99.18 L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HOLAGCBD_01572 7.8e-288 E Bacterial extracellular solute-binding proteins, family 5 Middle
HOLAGCBD_01573 0.0 valS 6.1.1.9 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
HOLAGCBD_01574 0.0 S domain protein
HOLAGCBD_01575 1e-69 tyrA 5.4.99.5 E Chorismate mutase type II
HOLAGCBD_01576 1.3e-79 K helix_turn_helix ASNC type
HOLAGCBD_01577 2.8e-246 rho K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HOLAGCBD_01578 0.0 5.4.99.9 H Flavin containing amine oxidoreductase
HOLAGCBD_01579 2.1e-51 S Protein of unknown function (DUF2469)
HOLAGCBD_01580 2e-205 2.3.1.57 J Acetyltransferase (GNAT) domain
HOLAGCBD_01581 8.7e-284 gatB 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HOLAGCBD_01582 4.2e-286 gatA 6.3.5.6, 6.3.5.7 F Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
HOLAGCBD_01583 5e-46 gatC 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HOLAGCBD_01584 6.2e-134 K Psort location Cytoplasmic, score
HOLAGCBD_01585 3.1e-133 spoU 2.1.1.185 J RNA methyltransferase TrmH family
HOLAGCBD_01586 2.7e-104 pyrE 2.4.2.10 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HOLAGCBD_01587 7e-168 rmuC S RmuC family
HOLAGCBD_01588 1e-132 3.6.3.3, 3.6.3.5, 3.6.3.54 P Heavy metal translocating P-type atpase
HOLAGCBD_01589 0.0 clpB O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
HOLAGCBD_01590 5.8e-174 fahA Q Fumarylacetoacetate (FAA) hydrolase family
HOLAGCBD_01591 6.5e-148 yggS S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HOLAGCBD_01592 2.5e-80
HOLAGCBD_01593 1.1e-211 gluQ 6.1.1.17 J Belongs to the class-I aminoacyl-tRNA synthetase family
HOLAGCBD_01594 8.1e-22 M Protein of unknown function (DUF3152)
HOLAGCBD_01595 1.4e-125 gla U Belongs to the MIP aquaporin (TC 1.A.8) family
HOLAGCBD_01597 1.7e-70 rplI J Binds to the 23S rRNA
HOLAGCBD_01598 3.5e-36 rpsR J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HOLAGCBD_01599 3.8e-66 ssb1 L Single-stranded DNA-binding protein
HOLAGCBD_01600 2.5e-46 rpsF J Binds together with S18 to 16S ribosomal RNA
HOLAGCBD_01601 1.6e-185 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HOLAGCBD_01602 5.7e-175 rbsK 2.7.1.15 H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HOLAGCBD_01603 1.1e-259 EGP Major Facilitator Superfamily
HOLAGCBD_01604 2.8e-166 iunH2 3.2.2.1 F Inosine-uridine preferring nucleoside hydrolase
HOLAGCBD_01605 1.8e-195 K helix_turn _helix lactose operon repressor
HOLAGCBD_01606 1.2e-61
HOLAGCBD_01607 4.9e-232 S AAA domain
HOLAGCBD_01608 6.2e-204 rfbB 4.2.1.46 M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
HOLAGCBD_01609 2e-307 XK27_08315 M Psort location CytoplasmicMembrane, score 9.26
HOLAGCBD_01610 9.9e-114 M Glycosyltransferase like family 2
HOLAGCBD_01611 1.2e-76 rfbN GT2 M Glycosyl transferase family 2
HOLAGCBD_01612 1.2e-108 wbbX GT2,GT4 M transferase activity, transferring glycosyl groups
HOLAGCBD_01613 2.4e-24 rgpF GT2,GT4 M Rhamnan synthesis protein F
HOLAGCBD_01614 1.4e-110 rgpC U Transport permease protein
HOLAGCBD_01615 7e-170 rgpD 3.6.3.38 GM ABC transporter, ATP-binding protein
HOLAGCBD_01616 5.5e-31 licD2 M LicD family
HOLAGCBD_01617 3.6e-155 rfbA 2.7.7.24 H Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HOLAGCBD_01618 8.2e-263 rmlC 1.1.1.133, 5.1.3.13 M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
HOLAGCBD_01619 7.7e-199 rfbB 4.2.1.46 M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
HOLAGCBD_01620 1.6e-80 S enterobacterial common antigen metabolic process
HOLAGCBD_01621 4.6e-36
HOLAGCBD_01622 1.7e-237 5.4.99.9 H Flavin containing amine oxidoreductase
HOLAGCBD_01623 1.8e-204 lytC 3.2.1.17, 3.2.1.96 M Glycosyl hydrolases family 25
HOLAGCBD_01624 1.4e-75
HOLAGCBD_01625 1e-08
HOLAGCBD_01626 2e-300 3.1.1.53 E Carbohydrate esterase, sialic acid-specific acetylesterase
HOLAGCBD_01627 6.2e-58
HOLAGCBD_01628 2.7e-80
HOLAGCBD_01629 5e-173
HOLAGCBD_01630 6.5e-137 L HNH endonuclease
HOLAGCBD_01632 5.5e-172 S Domain of unknown function (DUF4928)
HOLAGCBD_01633 3.3e-230 dcm 2.1.1.37 L Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family
HOLAGCBD_01635 1e-89 T AAA domain
HOLAGCBD_01636 3.8e-57 T regulation of circadian rhythm
HOLAGCBD_01637 1.6e-181 T regulation of circadian rhythm
HOLAGCBD_01638 1.1e-26
HOLAGCBD_01639 2.9e-64 L Phage integrase, N-terminal SAM-like domain
HOLAGCBD_01641 4.3e-90 EGP Major facilitator Superfamily
HOLAGCBD_01642 2.2e-58 EGP Major facilitator Superfamily
HOLAGCBD_01643 1.6e-44
HOLAGCBD_01644 1.5e-141 nfrA 1.5.1.38, 1.5.1.39 C Nitroreductase family
HOLAGCBD_01645 1.9e-62 S Protein of unknown function (DUF4235)
HOLAGCBD_01646 2.9e-136 G Phosphoglycerate mutase family
HOLAGCBD_01647 1.3e-257 amyE G Bacterial extracellular solute-binding protein
HOLAGCBD_01648 0.0 3.2.1.10, 3.2.1.20, 3.2.1.93 GH13,GH31 G Alpha-amylase domain
HOLAGCBD_01649 1.2e-263 amyE G Bacterial extracellular solute-binding protein
HOLAGCBD_01650 5.3e-187 K Periplasmic binding protein-like domain
HOLAGCBD_01651 1.7e-182 K Psort location Cytoplasmic, score
HOLAGCBD_01652 4.1e-153 msmF G Binding-protein-dependent transport system inner membrane component
HOLAGCBD_01653 1.5e-152 rafG G ABC transporter permease
HOLAGCBD_01654 4.9e-105 S Protein of unknown function, DUF624
HOLAGCBD_01655 9.7e-109 pepE 3.4.13.21 E Peptidase family S51
HOLAGCBD_01656 2.9e-13 S Transposon-encoded protein TnpV
HOLAGCBD_01657 0.0 malQ 2.4.1.18, 2.4.1.25, 3.2.1.196, 5.4.99.15 CBM48,GH13,GH77 G 4-alpha-glucanotransferase
HOLAGCBD_01658 0.0 malL 3.2.1.1, 5.4.99.16 GH13 G Alpha-amylase domain
HOLAGCBD_01659 5.6e-236 malE G Bacterial extracellular solute-binding protein
HOLAGCBD_01660 1.2e-247 malF G Binding-protein-dependent transport system inner membrane component
HOLAGCBD_01661 3.5e-163 malG G Binding-protein-dependent transport system inner membrane component
HOLAGCBD_01662 0.0 pulA 3.2.1.41 CBM48,GH13 G Belongs to the glycosyl hydrolase 13 family
HOLAGCBD_01663 7e-144 S HAD-hyrolase-like
HOLAGCBD_01664 1.4e-142 traX S TraX protein
HOLAGCBD_01665 1.3e-193 K Psort location Cytoplasmic, score
HOLAGCBD_01667 0.0 M cell wall anchor domain protein
HOLAGCBD_01668 2.8e-136 M LPXTG-motif cell wall anchor domain protein
HOLAGCBD_01669 1.1e-184 M Cna protein B-type domain
HOLAGCBD_01670 6.6e-122 srtC 3.4.22.70 M Sortase family
HOLAGCBD_01671 1.7e-125 S membrane transporter protein
HOLAGCBD_01672 0.0 phoA 3.1.3.1, 3.1.3.39 P Alkaline phosphatase homologues
HOLAGCBD_01673 1.2e-143 S Mitochondrial biogenesis AIM24
HOLAGCBD_01674 0.0 dnaK O Heat shock 70 kDa protein
HOLAGCBD_01675 2.8e-48 grpE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HOLAGCBD_01676 3.9e-158 dnaJ1 O DnaJ molecular chaperone homology domain
HOLAGCBD_01677 4.5e-115 hspR K transcriptional regulator, MerR family
HOLAGCBD_01678 4.3e-46
HOLAGCBD_01679 3.3e-129 S HAD hydrolase, family IA, variant 3
HOLAGCBD_01681 5.8e-126 dedA S SNARE associated Golgi protein
HOLAGCBD_01682 7.3e-18 3.2.1.78 GH26 G Glycosyl hydrolase family 26
HOLAGCBD_01683 5.2e-190 rsmI 2.1.1.198 H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HOLAGCBD_01684 1.1e-106
HOLAGCBD_01685 0.0 metG 6.1.1.10 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HOLAGCBD_01686 0.0 cbgA_1 3.2.1.23 G Belongs to the glycosyl hydrolase 2 family
HOLAGCBD_01687 6.6e-135 tenA 3.5.99.2 K Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. Thus, catalyzes the conversion of 4-amino-5-aminomethyl-2-methylpyrimidine to 4-amino- 5-hydroxymethyl-2-methylpyrimidine (HMP)
HOLAGCBD_01688 0.0 lacL 3.2.1.23 G Psort location Cytoplasmic, score 8.87
HOLAGCBD_01689 4.8e-261 lacS G Psort location CytoplasmicMembrane, score 10.00
HOLAGCBD_01690 3.6e-210 GK ROK family
HOLAGCBD_01691 4.2e-242 G Bacterial extracellular solute-binding protein
HOLAGCBD_01692 7.5e-147 G Binding-protein-dependent transport system inner membrane component
HOLAGCBD_01693 4.4e-164 G ABC transporter permease
HOLAGCBD_01694 6.6e-173 2.7.1.2 GK ROK family
HOLAGCBD_01695 0.0 G Glycosyl hydrolase family 20, domain 2
HOLAGCBD_01696 1.2e-149 nagB 3.1.1.31, 3.5.99.6 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
HOLAGCBD_01697 1.6e-233 nagA 3.5.1.25 G Amidohydrolase family
HOLAGCBD_01698 2.3e-187 lacR K Transcriptional regulator, LacI family
HOLAGCBD_01699 0.0 T Diguanylate cyclase, GGDEF domain
HOLAGCBD_01700 4.2e-250 3.2.1.14 GH18 S Carbohydrate binding domain
HOLAGCBD_01701 0.0 M probably involved in cell wall
HOLAGCBD_01702 2.6e-235 M Protein of unknown function (DUF2961)
HOLAGCBD_01703 5.5e-147 I alpha/beta hydrolase fold
HOLAGCBD_01704 1.7e-152 S AAA domain
HOLAGCBD_01705 1.1e-203 lipA I Hydrolase, alpha beta domain protein
HOLAGCBD_01706 2.1e-140 mdlA2 V ABC transporter
HOLAGCBD_01707 0.0 tetP J elongation factor G
HOLAGCBD_01708 1.2e-184 mdlA2 V ABC transporter
HOLAGCBD_01709 0.0 yknV V ABC transporter
HOLAGCBD_01710 8e-126
HOLAGCBD_01711 0.0 rafA 3.2.1.22 G Psort location Cytoplasmic, score 8.87
HOLAGCBD_01712 6.6e-221 K helix_turn _helix lactose operon repressor
HOLAGCBD_01713 2.3e-233 G Alpha galactosidase A
HOLAGCBD_01714 0.0 G Alpha-L-arabinofuranosidase C-terminus
HOLAGCBD_01715 2.2e-184 tatD L TatD related DNase
HOLAGCBD_01716 0.0 kup P Transport of potassium into the cell
HOLAGCBD_01717 1e-167 S Glutamine amidotransferase domain
HOLAGCBD_01718 5.1e-150 T HD domain
HOLAGCBD_01719 2.4e-156 V ABC transporter
HOLAGCBD_01720 6.2e-241 V ABC transporter permease
HOLAGCBD_01721 0.0 S Psort location CytoplasmicMembrane, score 9.99
HOLAGCBD_01722 0.0 3.2.1.21 GH3 G Fibronectin type III-like domain
HOLAGCBD_01723 0.0 KLT Protein tyrosine kinase
HOLAGCBD_01724 7.5e-151 O Thioredoxin
HOLAGCBD_01726 1.6e-197 S G5
HOLAGCBD_01727 2e-166 ksgA 2.1.1.182, 2.1.1.184 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
HOLAGCBD_01728 3.3e-169 ispE 2.1.1.182, 2.7.1.148 F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HOLAGCBD_01729 2.6e-109 S LytR cell envelope-related transcriptional attenuator
HOLAGCBD_01730 1.7e-284 cca 2.7.7.19, 2.7.7.72 J Probable RNA and SrmB- binding site of polymerase A
HOLAGCBD_01731 1.8e-121 deoC 3.6.1.13, 3.6.1.17, 3.6.1.55, 3.6.1.61 L Belongs to the Nudix hydrolase family
HOLAGCBD_01732 0.0 M Conserved repeat domain
HOLAGCBD_01733 4.1e-306 murJ KLT MviN-like protein
HOLAGCBD_01734 0.0 murJ KLT MviN-like protein
HOLAGCBD_01735 5.7e-13 S Domain of unknown function (DUF4143)
HOLAGCBD_01736 1.4e-121 yorS 3.1.3.5 S 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
HOLAGCBD_01738 9.1e-14 S Psort location Extracellular, score 8.82
HOLAGCBD_01739 3.1e-181 trxB 1.8.1.9, 4.3.1.9 C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
HOLAGCBD_01740 8.9e-203 parB K Belongs to the ParB family
HOLAGCBD_01741 4.5e-172 parA D CobQ CobB MinD ParA nucleotide binding domain protein
HOLAGCBD_01742 1.2e-127 rsmG 2.1.1.170 J Specifically methylates the N7 position of a guanine in 16S rRNA
HOLAGCBD_01743 3.6e-91 jag S Putative single-stranded nucleic acids-binding domain
HOLAGCBD_01744 3.9e-190 yidC U Membrane protein insertase, YidC Oxa1 family
HOLAGCBD_01745 1.5e-43 rnpA 3.1.26.5 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
HOLAGCBD_01746 5.9e-14 rpmH J Belongs to the bacterial ribosomal protein bL34 family
HOLAGCBD_01747 2.9e-306 dnaA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HOLAGCBD_01748 1e-204 dnaN 2.7.7.7 L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
HOLAGCBD_01749 3.7e-235 recF L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HOLAGCBD_01750 6.2e-90 S Protein of unknown function (DUF721)
HOLAGCBD_01751 0.0 gyrB 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HOLAGCBD_01752 0.0 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HOLAGCBD_01753 3.3e-68 S Transmembrane domain of unknown function (DUF3566)
HOLAGCBD_01754 1.2e-260 gdhA 1.4.1.4 E Belongs to the Glu Leu Phe Val dehydrogenases family
HOLAGCBD_01755 2.9e-58 mscL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
HOLAGCBD_01759 3.1e-101 S Protein of unknown function DUF45
HOLAGCBD_01760 3.4e-188 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
HOLAGCBD_01761 3.4e-239 ytfL P Transporter associated domain
HOLAGCBD_01762 2e-118 cah 4.2.1.1 P Reversible hydration of carbon dioxide
HOLAGCBD_01763 1.1e-25
HOLAGCBD_01764 1.1e-38
HOLAGCBD_01765 4.3e-66
HOLAGCBD_01766 0.0 ppc 4.1.1.31 H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HOLAGCBD_01767 0.0 yjjP S Threonine/Serine exporter, ThrE
HOLAGCBD_01768 9.4e-300 putP E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HOLAGCBD_01769 1.7e-204 trpS 6.1.1.2 J Belongs to the class-I aminoacyl-tRNA synthetase family
HOLAGCBD_01770 1.4e-41 S Protein of unknown function (DUF3073)
HOLAGCBD_01771 1.7e-63 I Sterol carrier protein
HOLAGCBD_01772 0.0 glgP 2.4.1.1 GT35 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
HOLAGCBD_01773 1.5e-35
HOLAGCBD_01774 2.8e-148 gluP 3.4.21.105 S Rhomboid family
HOLAGCBD_01775 1.2e-236 L ribosomal rna small subunit methyltransferase
HOLAGCBD_01776 1.8e-57 crgA D Involved in cell division
HOLAGCBD_01777 2.6e-141 S Bacterial protein of unknown function (DUF881)
HOLAGCBD_01778 8.7e-209 srtA 3.4.22.70 M Sortase family
HOLAGCBD_01779 8.7e-116 trpG 2.6.1.85 EH para-aminobenzoate synthase glutamine amidotransferase component II
HOLAGCBD_01780 0.0 pknB 2.7.11.1 KLT Protein tyrosine kinase
HOLAGCBD_01781 5.8e-177 T Protein tyrosine kinase
HOLAGCBD_01782 1.8e-265 pbpA M penicillin-binding protein
HOLAGCBD_01783 9.8e-275 rodA D Belongs to the SEDS family
HOLAGCBD_01784 6.8e-242 pstP 3.1.3.16 T Sigma factor PP2C-like phosphatases
HOLAGCBD_01785 9.6e-73 fhaB T Inner membrane component of T3SS, cytoplasmic domain
HOLAGCBD_01786 1.2e-131 fhaA T Protein of unknown function (DUF2662)
HOLAGCBD_01787 0.0 dpp4 3.4.14.5 E Dipeptidyl peptidase IV (DPP IV) N-terminal region
HOLAGCBD_01788 3.5e-225 2.7.13.3 T Histidine kinase
HOLAGCBD_01789 3.2e-113 K helix_turn_helix, Lux Regulon
HOLAGCBD_01790 6.6e-193 pldB 3.1.1.5 I Serine aminopeptidase, S33
HOLAGCBD_01791 8.8e-160 yicL EG EamA-like transporter family
HOLAGCBD_01792 5.4e-86 XK27_10430 S NAD(P)H-binding
HOLAGCBD_01793 3.5e-44 ydeP K HxlR-like helix-turn-helix
HOLAGCBD_01795 2.1e-268 tgt 2.4.2.29 F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
HOLAGCBD_01796 3.4e-283 degP O Domain present in PSD-95, Dlg, and ZO-1/2.
HOLAGCBD_01797 0.0 cadA P E1-E2 ATPase
HOLAGCBD_01798 6.7e-187 ansA 3.5.1.1 EJ Asparaginase
HOLAGCBD_01799 3.1e-270 fprA 1.18.1.2, 1.19.1.1 C Pyridine nucleotide-disulphide oxidoreductase
HOLAGCBD_01800 2.3e-161 htpX O Belongs to the peptidase M48B family
HOLAGCBD_01802 3.2e-65 K Helix-turn-helix XRE-family like proteins
HOLAGCBD_01803 1.6e-169 yddG EG EamA-like transporter family
HOLAGCBD_01804 0.0 pip S YhgE Pip domain protein
HOLAGCBD_01805 0.0 pip S YhgE Pip domain protein
HOLAGCBD_01806 4.1e-206 fbaA 4.1.2.13 G Fructose-bisphosphate aldolase class-II
HOLAGCBD_01807 3.5e-249 purA 6.3.4.4 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HOLAGCBD_01808 2.2e-154 clcA P Voltage gated chloride channel

eggNOG-mapper v2 (Database: eggNOG v5.0, Jul. 2018 release)