ORF_ID e_value Gene_name EC_number CAZy COGs Description
APENOPEN_00001 1.5e-24 secA2 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
APENOPEN_00002 2e-25 asp3 S Accessory Sec secretory system ASP3
APENOPEN_00003 5.3e-92 asp2 3.4.11.5 S Accessory Sec system GspB-transporter
APENOPEN_00004 1.1e-18 asp1 S Accessory Sec system protein Asp1
APENOPEN_00005 0.0 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APENOPEN_00006 4.5e-128 fpg 3.2.2.23, 4.2.99.18 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
APENOPEN_00007 1.2e-50 coaE 2.7.1.24 F Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
APENOPEN_00008 8e-66 nrdR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APENOPEN_00009 2.7e-74 dnaB L replication initiation and membrane attachment
APENOPEN_00010 2.5e-92 dnaI L Primosomal protein DnaI
APENOPEN_00011 2.3e-79 infC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
APENOPEN_00012 6.3e-25 rpmI J Belongs to the bacterial ribosomal protein bL35 family
APENOPEN_00013 5.8e-53 rplT J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
APENOPEN_00014 7.3e-68 yqeG S HAD phosphatase, family IIIA
APENOPEN_00015 5e-183 yqeH S Ribosome biogenesis GTPase YqeH
APENOPEN_00016 3.3e-36 yhbY J RNA-binding protein
APENOPEN_00017 1.3e-84 nadD 2.7.7.18, 3.6.1.55 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
APENOPEN_00018 6e-82 nadD 2.7.6.3, 2.7.7.18 H Hydrolase, HD family
APENOPEN_00019 4.3e-48 rsfS J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
APENOPEN_00020 1.5e-82 yqeM Q Methyltransferase
APENOPEN_00021 1.3e-151 ylbM S Belongs to the UPF0348 family
APENOPEN_00022 3.9e-64 yceD S Uncharacterized ACR, COG1399
APENOPEN_00023 5.1e-26 rpmF J Belongs to the bacterial ribosomal protein bL32 family
APENOPEN_00024 8.4e-117 K response regulator
APENOPEN_00025 1.3e-162 arlS 2.7.13.3 T Histidine kinase
APENOPEN_00026 2.2e-140 V MatE
APENOPEN_00027 1.6e-38 def_1 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins
APENOPEN_00028 7.6e-100 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
APENOPEN_00029 8.5e-20 acyP 3.6.1.7 C Belongs to the acylphosphatase family
APENOPEN_00030 2e-106 spoU 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APENOPEN_00031 1.6e-109 S Type IV secretion-system coupling protein DNA-binding domain
APENOPEN_00033 5.2e-105 ycsI S Belongs to the D-glutamate cyclase family
APENOPEN_00034 5.7e-43 L Helicase C-terminal domain protein
APENOPEN_00035 5.4e-113 I alpha/beta hydrolase fold
APENOPEN_00036 4.7e-99 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
APENOPEN_00037 1.1e-130 mleP2 S Sodium Bile acid symporter family
APENOPEN_00038 2.8e-126 lacM 3.2.1.23, 3.2.1.35, 3.2.1.51, 3.2.1.97 GH101,GH29 G beta-galactosidase
APENOPEN_00039 1.9e-296 lacL 3.2.1.23 G Belongs to the glycosyl hydrolase 2 family
APENOPEN_00041 7.8e-55 ydcK S Belongs to the SprT family
APENOPEN_00042 2.4e-295 yhgF K Tex-like protein N-terminal domain protein
APENOPEN_00043 2.3e-116 nadE 6.3.1.5 F Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
APENOPEN_00044 2.3e-233 pncB 6.3.4.21 F Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
APENOPEN_00045 2.6e-105 gntR1 K UbiC transcription regulator-associated domain protein
APENOPEN_00046 3.5e-105 racD 5.1.1.13 M Belongs to the aspartate glutamate racemases family
APENOPEN_00047 9.1e-218 aspT P Predicted Permease Membrane Region
APENOPEN_00048 2.8e-143 EGP Major facilitator Superfamily
APENOPEN_00049 1.6e-40
APENOPEN_00052 3.7e-90 yjjH S Calcineurin-like phosphoesterase
APENOPEN_00053 5.5e-230 dtpT U amino acid peptide transporter
APENOPEN_00054 1.3e-75 ywlG S Belongs to the UPF0340 family
APENOPEN_00055 8.5e-86 adh 1.1.1.1, 1.1.1.14 E alcohol dehydrogenase
APENOPEN_00058 2.3e-18 copZ P Heavy-metal-associated domain
APENOPEN_00059 6.8e-198 cadA 3.6.3.3, 3.6.3.5 P P-type ATPase
APENOPEN_00060 3.6e-167 cycA E Amino acid permease
APENOPEN_00061 3.5e-221 S Peptidase M60-like family
APENOPEN_00062 7e-80 nhaC C Na H antiporter NhaC
APENOPEN_00063 4e-28 nhaC C Na H antiporter NhaC
APENOPEN_00064 5.8e-52 nudG 3.6.1.55, 3.6.1.65 L NUDIX domain
APENOPEN_00066 5.7e-250 nplT 3.2.1.133, 3.2.1.135, 3.2.1.54 GH13 G Belongs to the glycosyl hydrolase 13 family
APENOPEN_00069 2.1e-98 tesE Q hydratase
APENOPEN_00071 6.6e-24 dmpI 5.3.2.6 G Belongs to the 4-oxalocrotonate tautomerase family
APENOPEN_00072 9.7e-251 glpK 2.7.1.30 F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
APENOPEN_00073 2.7e-120 f42a O Band 7 protein
APENOPEN_00074 1.5e-154 ktrB P Potassium uptake protein
APENOPEN_00075 1.1e-68 ktrA P domain protein
APENOPEN_00076 2.5e-200 cadA P P-type ATPase
APENOPEN_00081 1.3e-123 4.2.1.53 S Myosin-crossreactive antigen
APENOPEN_00082 8.1e-38 L transposase, IS605 OrfB family
APENOPEN_00083 4.5e-18 C nitroreductase
APENOPEN_00084 4.3e-107 yitU 3.1.3.104 S hydrolase
APENOPEN_00085 5.9e-37 fic D Fic/DOC family
APENOPEN_00086 2.3e-190 rsmF 2.1.1.176, 2.1.1.178 J NOL1 NOP2 sun family protein
APENOPEN_00087 1.6e-33 spx4 1.20.4.1 P ArsC family
APENOPEN_00088 1.6e-26 K Bacterial regulatory proteins, tetR family
APENOPEN_00089 6.1e-120 scrK 2.7.1.2, 2.7.1.4 GK ROK family
APENOPEN_00090 1.3e-77 opuCD P Binding-protein-dependent transport system inner membrane component
APENOPEN_00091 4.5e-105 opuCC M Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
APENOPEN_00092 2e-83 opuCB E ABC transporter permease
APENOPEN_00093 2.3e-130 opuCA 2.7.7.7 E ABC transporter, ATP-binding protein
APENOPEN_00094 1e-110 fni 1.1.1.88, 5.3.3.2 C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
APENOPEN_00095 1.9e-163 mvaK2 2.7.1.36, 2.7.1.43, 2.7.4.2 I phosphomevalonate kinase
APENOPEN_00096 4.1e-101 mvaD 4.1.1.33 I diphosphomevalonate decarboxylase
APENOPEN_00097 1.2e-105 mvk 1.1.1.88, 2.3.3.10, 2.7.1.36 I mevalonate kinase
APENOPEN_00098 0.0 dinG 2.7.7.7, 3.6.4.12 L helicase involved in DNA repair and perhaps also replication
APENOPEN_00099 3.9e-58 ypmB S Protein conserved in bacteria
APENOPEN_00100 1e-227 asnS 6.1.1.22 J Asparaginyl-tRNA synthetase
APENOPEN_00101 4e-51 dnaD L DnaD domain protein
APENOPEN_00102 4.9e-89 ypuA S Protein of unknown function (DUF1002)
APENOPEN_00103 2e-121 EG EamA-like transporter family
APENOPEN_00104 2.7e-281 ponA 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein 1A
APENOPEN_00105 1.1e-80 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
APENOPEN_00106 2.9e-54 ypsA S Belongs to the UPF0398 family
APENOPEN_00107 3.7e-47 gpsB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
APENOPEN_00108 2.3e-17 C Aldo keto reductase
APENOPEN_00109 5.6e-79 C Aldo keto reductase
APENOPEN_00110 1.3e-67 4.4.1.5 E Glyoxalase
APENOPEN_00111 2.5e-51 yueI S Protein of unknown function (DUF1694)
APENOPEN_00112 1.1e-194 rarA L recombination factor protein RarA
APENOPEN_00114 1.3e-71 usp6 T universal stress protein
APENOPEN_00115 2.1e-53 K Helix-turn-helix XRE-family like proteins
APENOPEN_00117 7.4e-96 IQ Enoyl-(Acyl carrier protein) reductase
APENOPEN_00118 1.2e-133 clcA P chloride
APENOPEN_00119 6.7e-95 ribA 3.5.4.25, 4.1.99.12 H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APENOPEN_00123 3.2e-141 manL 2.7.1.191 G PTS system sorbose subfamily IIB component
APENOPEN_00124 7.3e-104 manY G PTS system
APENOPEN_00125 1.5e-148 manN G system, mannose fructose sorbose family IID component
APENOPEN_00126 3.4e-38 S Domain of unknown function (DUF956)
APENOPEN_00127 1.8e-61 ndk 2.7.4.6 F Belongs to the NDK family
APENOPEN_00128 4.9e-203 glnA 6.3.1.2 E glutamine synthetase
APENOPEN_00129 2.5e-09
APENOPEN_00130 2.6e-110
APENOPEN_00131 6e-98
APENOPEN_00132 8.7e-56 dut S Protein conserved in bacteria
APENOPEN_00133 5.8e-54 mnaA 5.1.3.14 G Belongs to the UDP-N-acetylglucosamine 2-epimerase family
APENOPEN_00134 3e-106 EGP Major facilitator Superfamily
APENOPEN_00135 3e-94 mtnU 3.5.1.3 S Carbon-nitrogen hydrolase
APENOPEN_00136 7.5e-198 mtnE 2.6.1.83 E Aminotransferase
APENOPEN_00138 5.9e-66 S Cell surface protein
APENOPEN_00140 3.7e-19 cadD P cadmium resistance
APENOPEN_00142 1.4e-216 yhjE EGP MFS transporter, metabolite H symporter (MHS) family protein
APENOPEN_00143 2e-148 EGP Major facilitator Superfamily
APENOPEN_00144 9.4e-98 ahpC 1.11.1.15 O Peroxiredoxin
APENOPEN_00145 2.7e-233 trxB2 1.8.1.9 C Thioredoxin domain
APENOPEN_00146 4.6e-53 K helix_turn_helix, arabinose operon control protein
APENOPEN_00147 4.2e-287 3.2.1.21 GH3 G hydrolase, family 3
APENOPEN_00148 4.3e-92 K helix_turn_helix, arabinose operon control protein
APENOPEN_00149 0.0 lacZ3 3.2.1.23 G Beta-galactosidase
APENOPEN_00150 1.7e-155 blt G MFS/sugar transport protein
APENOPEN_00151 1.8e-266 araB 2.7.1.12, 2.7.1.16, 2.7.1.17 G carbohydrate kinase FGGY
APENOPEN_00152 1.9e-130 araD 4.1.2.17, 5.1.3.4 G links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source
APENOPEN_00153 2.2e-148 araR K Transcriptional regulator
APENOPEN_00154 1.2e-212 EGP Major facilitator Superfamily
APENOPEN_00155 5.1e-241 araA 5.3.1.4 G Catalyzes the conversion of L-arabinose to L-ribulose
APENOPEN_00156 4.3e-121 K transcriptional regulator, ArsR family
APENOPEN_00157 5.5e-191 L transposase, IS605 OrfB family
APENOPEN_00158 0.0 dnaE 2.7.7.7 L DNA polymerase
APENOPEN_00159 4.6e-234 pyk 2.7.1.40, 2.7.7.4 G Belongs to the pyruvate kinase family
APENOPEN_00160 8.3e-133 cvfB S S1 domain
APENOPEN_00161 7.4e-60 xerD D recombinase XerD
APENOPEN_00162 1.6e-34 ribT K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
APENOPEN_00163 7.3e-77 scpA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
APENOPEN_00164 6.3e-71 scpB D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
APENOPEN_00165 3.3e-95 rluB 5.4.99.19, 5.4.99.21, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
APENOPEN_00166 1e-59 U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
APENOPEN_00167 3.7e-71 ypbB 5.1.3.1 S Helix-turn-helix domain
APENOPEN_00168 2e-144 recQ1 3.6.4.12 L ATP-dependent DNA helicase RecQ
APENOPEN_00169 2e-21 M Lysin motif
APENOPEN_00170 2.9e-82 cmk 1.17.7.4, 2.5.1.19, 2.7.1.26, 2.7.4.25, 2.7.7.2, 6.3.2.1 F Belongs to the cytidylate kinase family. Type 1 subfamily
APENOPEN_00171 2.7e-190 rpsA 1.17.7.4 J Ribosomal protein S1
APENOPEN_00172 2.3e-219 der 1.1.1.399, 1.1.1.95 S GTPase that plays an essential role in the late steps of ribosome biogenesis
APENOPEN_00173 8.2e-39 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
APENOPEN_00174 5.7e-108 deoD 2.4.2.1, 2.4.2.28 F Purine nucleoside phosphorylase
APENOPEN_00175 7.5e-183 pdp 2.4.2.2, 2.4.2.4 F pyrimidine-nucleoside phosphorylase
APENOPEN_00176 1.6e-195 deoB 5.4.2.7 G Phosphotransfer between the C1 and C5 carbon atoms of pentose
APENOPEN_00177 4.7e-88 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
APENOPEN_00179 1.4e-14
APENOPEN_00180 1.1e-113 uvrX 2.7.7.7 L Belongs to the DNA polymerase type-Y family
APENOPEN_00181 1.4e-09
APENOPEN_00182 1.8e-11 ybaN S Protein of unknown function (DUF454)
APENOPEN_00184 0.0 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APENOPEN_00185 3.1e-19 K Helix-turn-helix domain
APENOPEN_00186 2.7e-118 miaA 2.5.1.75 F Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
APENOPEN_00187 1.1e-15 WQ51_02665 S Protein of unknown function (DUF3042)
APENOPEN_00188 2.4e-50 yqhL P Rhodanese-like protein
APENOPEN_00189 1.1e-162 glk 2.7.1.2 G Glucokinase
APENOPEN_00190 1.5e-25 yqgQ S Bacterial protein of unknown function (DUF910)
APENOPEN_00191 2.6e-70 gluP 3.4.21.105 S Peptidase, S54 family
APENOPEN_00192 1.6e-65 ygfA 6.3.3.2 H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APENOPEN_00193 1.4e-19 rpmG J Belongs to the bacterial ribosomal protein bL33 family
APENOPEN_00194 2e-286 pbp2b 3.4.16.4 M Penicillin-binding Protein
APENOPEN_00195 3.6e-311 S membrane
APENOPEN_00196 5.6e-211 ctpA 3.6.3.54 P P-type ATPase
APENOPEN_00197 1.6e-32 silP 1.9.3.1, 3.6.3.54 S Cupredoxin-like domain
APENOPEN_00198 5e-68 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
APENOPEN_00199 3.3e-102 udk 2.7.1.48 F Cytidine monophosphokinase
APENOPEN_00200 1.3e-23 mltG S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
APENOPEN_00201 0.0 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
APENOPEN_00202 9.6e-181 pheS 6.1.1.20 J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
APENOPEN_00203 4.2e-45 yodB K Transcriptional regulator, HxlR family
APENOPEN_00204 4.1e-71 XK27_09705 6.1.1.14 S Metal dependent phosphohydrolases with conserved 'HD' motif.
APENOPEN_00205 5.8e-95 F DNA/RNA non-specific endonuclease
APENOPEN_00206 1.8e-105 yeaE S Aldo keto
APENOPEN_00207 9.1e-170 pepT 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
APENOPEN_00208 1.4e-07 S Uncharacterised conserved protein (DUF2156)
APENOPEN_00209 8.3e-204 yifK E Amino acid permease
APENOPEN_00210 1.4e-182 pipD E Dipeptidase
APENOPEN_00211 2.5e-100 endA F DNA RNA non-specific endonuclease
APENOPEN_00212 6.8e-13 nrdH O Glutaredoxin
APENOPEN_00213 9e-49 L Protein of unknown function (DUF3991)
APENOPEN_00214 1.7e-23 V endonuclease activity
APENOPEN_00215 3.2e-199 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APENOPEN_00216 5.1e-67 yqgF J Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
APENOPEN_00217 2e-34 yrzL S Belongs to the UPF0297 family
APENOPEN_00218 0.0 alaS 6.1.1.7 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APENOPEN_00219 5.5e-210 recN L May be involved in recombinational repair of damaged DNA
APENOPEN_00220 4.6e-47 argR K Regulates arginine biosynthesis genes
APENOPEN_00221 8.2e-127 rrmJ 2.1.1.226, 2.1.1.227 J Ribosomal RNA large subunit methyltransferase J
APENOPEN_00222 1.5e-113 ispA 2.5.1.1, 2.5.1.10, 2.5.1.29, 2.5.1.90 H Belongs to the FPP GGPP synthase family
APENOPEN_00223 5.2e-13 xseB 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
APENOPEN_00224 2.3e-102 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
APENOPEN_00225 1.9e-94 folD 1.5.1.5, 3.5.4.9 F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
APENOPEN_00226 2.5e-36 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APENOPEN_00227 1.7e-54 yqhY S Asp23 family, cell envelope-related function
APENOPEN_00228 1.6e-46 J 2'-5' RNA ligase superfamily
APENOPEN_00229 6.5e-148 pepP 3.4.11.9, 3.4.13.9 E Creatinase/Prolidase N-terminal domain
APENOPEN_00230 2.3e-28 yvkB K Bacterial regulatory proteins, tetR family
APENOPEN_00231 8.6e-70 arbV 2.3.1.51 I Acyl-transferase
APENOPEN_00232 2.6e-96 arbx M Glycosyl transferase family 8
APENOPEN_00233 4.4e-103 arbY M Glycosyl transferase family 8
APENOPEN_00234 1.5e-86 arbZ I Phosphate acyltransferases
APENOPEN_00235 8.3e-79 metAA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to
APENOPEN_00236 5.6e-148 cysK 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
APENOPEN_00237 2.8e-51 citG 2.4.2.52, 2.7.7.61 H 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase
APENOPEN_00238 3.3e-43 rpmA J Belongs to the bacterial ribosomal protein bL27 family
APENOPEN_00239 4.9e-27 ysxB J Cysteine protease Prp
APENOPEN_00240 2e-46 rplU J This protein binds to 23S rRNA in the presence of protein L20
APENOPEN_00241 4e-15 K Transcriptional regulator
APENOPEN_00242 6.6e-169 lmrB EGP Major facilitator Superfamily
APENOPEN_00243 9.2e-24 XK26_02160 C Pyridoxamine 5'-phosphate oxidase
APENOPEN_00244 1.4e-27 S Uncharacterized protein conserved in bacteria (DUF2325)
APENOPEN_00247 4.9e-72 ruvB 3.6.4.12 L four-way junction helicase activity
APENOPEN_00248 2.3e-24 S Streptococcus thermophilus bacteriophage Gp111 protein
APENOPEN_00250 6.6e-65 S Cell surface protein
APENOPEN_00252 6.7e-69 rpsL J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
APENOPEN_00253 2.2e-76 rpsG J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
APENOPEN_00254 0.0 fusA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APENOPEN_00255 2.2e-30
APENOPEN_00256 7.2e-239 pckA 4.1.1.49 H Phosphoenolpyruvate carboxykinase
APENOPEN_00257 1.1e-38 rpsO J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
APENOPEN_00258 5.3e-251 rnjB J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
APENOPEN_00259 6.6e-61 S Tetratricopeptide repeat
APENOPEN_00260 9.7e-132 1.6.5.2 GM NmrA-like family
APENOPEN_00261 8.2e-62 apt 2.4.2.7 F Phosphoribosyl transferase domain
APENOPEN_00262 4.2e-42 P secondary active sulfate transmembrane transporter activity
APENOPEN_00263 2e-202 N Uncharacterized conserved protein (DUF2075)
APENOPEN_00265 2.6e-26 lacA 2.3.1.79 S Maltose acetyltransferase
APENOPEN_00266 7.9e-37
APENOPEN_00267 8.8e-150 hrcA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
APENOPEN_00268 5.9e-50 grpE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
APENOPEN_00269 9.1e-283 dnaK O Heat shock 70 kDa protein
APENOPEN_00270 7.4e-158 dnaJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
APENOPEN_00271 0.0 lepA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
APENOPEN_00272 6.9e-254 poxB 1.2.3.3, 1.2.5.1 EH Belongs to the TPP enzyme family
APENOPEN_00273 8.3e-155 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
APENOPEN_00275 3e-214 argH 4.3.2.1 E argininosuccinate lyase
APENOPEN_00276 1.5e-199 argG 6.3.4.5 E Belongs to the argininosuccinate synthase family. Type 1 subfamily
APENOPEN_00278 7.1e-28
APENOPEN_00279 0.0 clpL O associated with various cellular activities
APENOPEN_00281 1.6e-221 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APENOPEN_00282 0.0 rexB 3.1.21.3, 3.6.4.12 L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' - 3' nuclease activity
APENOPEN_00283 0.0 addA 3.6.4.12 L ATP-dependent helicase nuclease subunit A
APENOPEN_00284 9.4e-78 KT YcbB domain
APENOPEN_00285 3.7e-224 ybeC E amino acid
APENOPEN_00286 1.5e-257 groL O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
APENOPEN_00287 3.2e-38 groS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
APENOPEN_00288 3.8e-103 rex K Modulates transcription in response to changes in cellular NADH NAD( ) redox state
APENOPEN_00289 2.1e-245 uup S ABC transporter, ATP-binding protein
APENOPEN_00290 3.9e-152 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
APENOPEN_00291 9.2e-28 S CHY zinc finger
APENOPEN_00292 1.3e-91 birA 6.3.4.15 H Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
APENOPEN_00293 7.6e-52 bioY S BioY family
APENOPEN_00294 3.9e-146 aspB 2.6.1.1, 2.6.1.14 E Aminotransferase
APENOPEN_00295 0.0 pyc 6.4.1.1 C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
APENOPEN_00296 1.3e-110 fabI 1.3.1.10, 1.3.1.9 I Enoyl- acyl-carrier-protein reductase NADH
APENOPEN_00297 7.1e-96 accA 2.1.3.15, 6.4.1.2 I alpha subunit
APENOPEN_00298 3.4e-107 accD 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
APENOPEN_00299 8.4e-209 accC 6.3.4.14, 6.4.1.2 I Acetyl-CoA carboxylase biotin carboxylase subunit
APENOPEN_00300 7.1e-61 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
APENOPEN_00301 1.3e-35 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
APENOPEN_00302 9e-194 fabF 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
APENOPEN_00303 1.2e-92 IQ reductase
APENOPEN_00304 4.2e-103 fabD 2.3.1.39 I Malonyl CoA-acyl carrier protein transacylase
APENOPEN_00305 9.1e-21 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
APENOPEN_00306 1.5e-111 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APENOPEN_00307 6.1e-60 marR K Transcriptional regulator, MarR family
APENOPEN_00308 7.8e-63 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
APENOPEN_00309 1.5e-165 tsaD 2.3.1.234 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
APENOPEN_00310 5.8e-39 rimI 2.3.1.128 K Ribosomal-protein-alanine acetyltransferase
APENOPEN_00311 1.6e-86 yeaZ 2.3.1.234 O Universal bacterial protein YeaZ
APENOPEN_00312 6.2e-177 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
APENOPEN_00313 2.9e-115 ppx 3.6.1.11, 3.6.1.40 FP exopolyphosphatase
APENOPEN_00314 0.0 ppk 2.7.4.1 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
APENOPEN_00315 7.6e-171 ppx3 3.6.1.11, 3.6.1.40 FP exopolyphosphatase
APENOPEN_00316 2e-66 fat 3.1.2.21 I Acyl-ACP thioesterase
APENOPEN_00317 5.6e-118 rsmI 2.1.1.198 H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
APENOPEN_00318 4.1e-27 yabA L Involved in initiation control of chromosome replication
APENOPEN_00319 1.7e-110 holB 2.7.7.7 L DNA polymerase III
APENOPEN_00320 9.6e-39 yaaQ S Cyclic-di-AMP receptor
APENOPEN_00321 3.3e-83 tmk 2.7.4.9 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APENOPEN_00322 3.3e-18 S Protein of unknown function (DUF2508)
APENOPEN_00323 6.1e-95 recR L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
APENOPEN_00324 1.2e-27 yaaK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
APENOPEN_00325 1.8e-208 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APENOPEN_00326 9.1e-57 tadA 3.5.4.33 F Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
APENOPEN_00327 5.8e-27 nrdH O Glutaredoxin
APENOPEN_00328 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APENOPEN_00329 5e-182 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APENOPEN_00330 3.4e-186 brnQ U Component of the transport system for branched-chain amino acids
APENOPEN_00331 0.0 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
APENOPEN_00332 1e-33 yveB 2.7.4.29 I PAP2 superfamily
APENOPEN_00333 6.9e-212 lysP E amino acid
APENOPEN_00334 3.3e-115 K Transcriptional regulator
APENOPEN_00335 4.5e-294 M Exporter of polyketide antibiotics
APENOPEN_00336 2.6e-169 yjjC V ABC transporter
APENOPEN_00337 4.7e-48 C Flavodoxin
APENOPEN_00338 5.4e-192 ykgC 1.16.1.1, 1.8.1.7 C Pyridine nucleotide-disulfide oxidoreductase
APENOPEN_00339 1.7e-77 S Cupin superfamily (DUF985)
APENOPEN_00340 4.8e-50 lytE M LysM domain protein
APENOPEN_00341 2.8e-53 ykhA 3.1.2.20 I Thioesterase superfamily
APENOPEN_00342 1e-47 lytE M LysM domain protein
APENOPEN_00343 2e-268 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APENOPEN_00344 9.1e-54 yxeH S hydrolase
APENOPEN_00345 5.3e-115 argC 1.2.1.38 E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APENOPEN_00346 1.1e-143 argJ 2.3.1.1, 2.3.1.35, 2.7.2.8 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
APENOPEN_00347 2.2e-70 argB 2.7.2.8 F Belongs to the acetylglutamate kinase family. ArgB subfamily
APENOPEN_00348 2.3e-143 argD 2.6.1.11, 2.6.1.17 E acetylornithine
APENOPEN_00349 4.5e-47 hsp O Belongs to the small heat shock protein (HSP20) family
APENOPEN_00350 1.3e-218 arcD S C4-dicarboxylate anaerobic carrier
APENOPEN_00351 4.2e-189 ytjP 3.5.1.18 E Dipeptidase
APENOPEN_00352 6.2e-21
APENOPEN_00353 1.1e-252 3.2.1.45 GH30 G Glycosyl hydrolase family 30 TIM-barrel domain
APENOPEN_00354 2.1e-48 G Phosphoglycerate mutase family
APENOPEN_00355 2.1e-18 K LysR substrate binding domain
APENOPEN_00356 2.4e-52 G Phosphoglycerate mutase family
APENOPEN_00357 5.5e-109 G PTS system sorbose-specific iic component
APENOPEN_00358 2.1e-142 brpA K Cell envelope-like function transcriptional attenuator common domain protein
APENOPEN_00359 2.7e-97 rfbB 4.2.1.46 M Male sterility protein
APENOPEN_00360 1.2e-106 ybbM S Uncharacterised protein family (UPF0014)
APENOPEN_00361 1.6e-61 ybbL S ABC transporter, ATP-binding protein
APENOPEN_00363 1.4e-20 glxI 4.4.1.5 E lactoylglutathione lyase activity
APENOPEN_00365 8.7e-164 nylA 3.5.1.4 J Belongs to the amidase family
APENOPEN_00366 1.5e-78 mleR K LysR family
APENOPEN_00367 3.8e-224 sfcA 1.1.1.38, 4.1.1.101 C Malic enzyme
APENOPEN_00368 7.2e-67 ntd 2.4.2.6 F Nucleoside
APENOPEN_00369 4.5e-130 ltaE 4.1.2.48 E Beta-eliminating lyase
APENOPEN_00370 5.6e-71 ydfK S Na channel or pump
APENOPEN_00371 2.7e-70 K LysR substrate binding domain
APENOPEN_00373 2.1e-117 adhC 1.1.1.90 C Alcohol dehydrogenase GroES-like domain
APENOPEN_00374 7.4e-91 nadC 1.4.3.16, 2.4.2.19 H Quinolinate phosphoribosyl transferase, C-terminal domain
APENOPEN_00375 8.2e-168 yceI EGP Major facilitator Superfamily
APENOPEN_00376 5.9e-63 tag 3.2.2.20 L Methyladenine glycosylase
APENOPEN_00377 1.1e-35 4.1.1.44 O Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APENOPEN_00378 3.2e-106 pcaC 4.1.1.44 S Cupin domain
APENOPEN_00379 1.4e-108 S Aldo/keto reductase family
APENOPEN_00380 3e-155 ydgH S MMPL family
APENOPEN_00381 2.8e-13 3.1.3.48 D FIVAR domain
APENOPEN_00382 6.4e-160 thrC 4.2.3.1 E Threonine synthase
APENOPEN_00383 8.2e-74 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
APENOPEN_00384 1.3e-203 mpl 6.3.2.4, 6.3.2.45, 6.3.2.8 M Belongs to the MurCDEF family
APENOPEN_00385 1.4e-82 ybhL S Belongs to the BI1 family
APENOPEN_00386 4.4e-74 S Fic/DOC family
APENOPEN_00388 1.4e-47
APENOPEN_00389 8.3e-38
APENOPEN_00391 1.8e-44
APENOPEN_00392 1.1e-58 XK27_08875 O PFAM peptidase M10A and M12B, matrixin and adamalysin
APENOPEN_00393 5.6e-129 EG EamA-like transporter family
APENOPEN_00394 2.4e-28 L Transposase
APENOPEN_00395 1.5e-110 S Polyphosphate nucleotide phosphotransferase, PPK2 family
APENOPEN_00398 4.8e-56 S SNARE associated Golgi protein
APENOPEN_00399 2.4e-109 yvgN C Aldo keto reductase
APENOPEN_00400 6.3e-113 XK27_08845 S ABC transporter, ATP-binding protein
APENOPEN_00401 3.4e-126 XK27_08840 U Belongs to the binding-protein-dependent transport system permease family
APENOPEN_00402 1.1e-141 ABC-SBP S ABC transporter
APENOPEN_00403 1.7e-144 sufS 2.8.1.7, 4.4.1.16 E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APENOPEN_00404 5.7e-42 nifU C SUF system FeS assembly protein, NifU family
APENOPEN_00405 5e-40 M PFAM NLP P60 protein
APENOPEN_00406 1.2e-35 S NADPH-dependent FMN reductase
APENOPEN_00407 1.2e-251 S ABC transporter, ATP-binding protein
APENOPEN_00408 8.5e-136 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
APENOPEN_00409 3.6e-116 S Uncharacterized protein conserved in bacteria (DUF2325)
APENOPEN_00410 4.9e-143 nrnB S DHHA1 domain
APENOPEN_00411 1.7e-78 K Transcriptional regulator, LacI family
APENOPEN_00412 6.3e-214 yjmB G MFS/sugar transport protein
APENOPEN_00413 2.7e-35
APENOPEN_00414 2e-190 proWX EM Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
APENOPEN_00415 1.6e-110 E ABC transporter, ATP-binding protein
APENOPEN_00416 9.6e-20 dnaQ 2.7.7.7 L Psort location Cytoplasmic, score 8.87
APENOPEN_00418 2.5e-27 arbB 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
APENOPEN_00419 2.3e-163 uvrX 2.7.7.7 L Belongs to the DNA polymerase type-Y family
APENOPEN_00420 3.3e-07
APENOPEN_00422 2.3e-173 L Transposase and inactivated derivatives, IS30 family
APENOPEN_00423 4.7e-25
APENOPEN_00424 9.1e-45 mco Q Multicopper oxidase
APENOPEN_00425 1.7e-24
APENOPEN_00426 8.1e-156 tagE3 2.4.1.52 GT4 M Glycosyl transferases group 1
APENOPEN_00427 3.1e-180 tagE2 2.4.1.52 GT4 M Poly(Glycerol-phosphate) alpha-glucosyltransferase
APENOPEN_00428 8.3e-88 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APENOPEN_00429 3e-24 rpmF J Belongs to the bacterial ribosomal protein bL32 family
APENOPEN_00430 2.6e-182 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
APENOPEN_00431 7.3e-119 ytxK 2.1.1.72 L N-6 DNA Methylase
APENOPEN_00434 1.4e-22 NU general secretion pathway protein
APENOPEN_00435 1.5e-20 comGC U competence protein ComGC
APENOPEN_00436 1.8e-61 comGB NU type II secretion system
APENOPEN_00437 1.6e-100 comGA NU Type II IV secretion system protein
APENOPEN_00438 9.1e-117 yebC K Transcriptional regulatory protein
APENOPEN_00439 8.9e-28
APENOPEN_00440 7.3e-141 ccpA K catabolite control protein A
APENOPEN_00441 8.9e-169 pepQ 3.4.13.9 E Creatinase/Prolidase N-terminal domain
APENOPEN_00442 3.9e-12
APENOPEN_00444 2e-72 ykuT M mechanosensitive ion channel
APENOPEN_00445 1.4e-172 murE 6.3.2.13, 6.3.2.7 M Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APENOPEN_00446 9.5e-88 lepB 3.4.21.89 U Belongs to the peptidase S26 family
APENOPEN_00447 1.6e-177 pepC 3.4.22.40 E aminopeptidase
APENOPEN_00448 1.8e-198 pipD E Dipeptidase
APENOPEN_00449 5.9e-295 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
APENOPEN_00451 2.6e-238 mntH P H( )-stimulated, divalent metal cation uptake system
APENOPEN_00452 4.8e-177 tdh 1.1.1.14 E Alcohol dehydrogenase GroES-like domain
APENOPEN_00453 2.2e-40 ygfC K transcriptional regulator (TetR family)
APENOPEN_00454 1.8e-105 hrtB V ABC transporter permease
APENOPEN_00455 1.6e-83 devA 3.6.3.25 V ABC transporter, ATP-binding protein
APENOPEN_00456 4.9e-34 L Belongs to the 'phage' integrase family
APENOPEN_00458 1.8e-52 3.6.1.27 I Acid phosphatase homologues
APENOPEN_00459 4.8e-144 phbA 2.3.1.9 I Belongs to the thiolase family
APENOPEN_00465 1e-42 M transferase activity, transferring glycosyl groups
APENOPEN_00466 5e-15 nss M transferase activity, transferring glycosyl groups
APENOPEN_00467 6.8e-61 secY2 U Part of the accessory SecA2 SecY2 system specifically required for export of
APENOPEN_00468 7.8e-78 M transferase activity, transferring glycosyl groups
APENOPEN_00469 1.4e-87 asp2 3.4.11.5 S Accessory Sec system GspB-transporter
APENOPEN_00470 1.8e-23 asp3 S Accessory Sec secretory system ASP3
APENOPEN_00471 5.9e-234 secA2 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
APENOPEN_00472 4.1e-148 gtf1 2.4.1.52 GT4 M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
APENOPEN_00473 6e-119 gtf2 M A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1
APENOPEN_00475 3.1e-77 L PFAM transposase, IS4 family protein
APENOPEN_00476 2.2e-12 L PFAM transposase, IS4 family protein
APENOPEN_00477 5.4e-148 mvaS 2.3.3.10 I Hydroxymethylglutaryl-CoA synthase
APENOPEN_00478 7e-90 XK27_07210 6.1.1.6 S B3 4 domain
APENOPEN_00479 6.3e-52 yybA 2.3.1.57 K Transcriptional regulator
APENOPEN_00480 1.7e-67 rnhA 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APENOPEN_00481 1.8e-246 aha1 P E1-E2 ATPase
APENOPEN_00482 2.1e-74 3.1.3.73 G phosphoglycerate mutase
APENOPEN_00483 1.9e-131 serC 2.6.1.52 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
APENOPEN_00484 1e-154 serA 1.1.1.399, 1.1.1.95 EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APENOPEN_00485 1.3e-278 mycA 4.2.1.53 S Myosin-crossreactive antigen
APENOPEN_00486 2.3e-258 rnjA J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
APENOPEN_00487 5.1e-93 S CAAX protease self-immunity
APENOPEN_00488 7e-129 uppP 3.6.1.27 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
APENOPEN_00489 3.6e-261 mco Q Multicopper oxidase
APENOPEN_00490 2.8e-71 usp1 T Belongs to the universal stress protein A family
APENOPEN_00491 4.2e-84 S VIT family
APENOPEN_00492 9.7e-89 S membrane
APENOPEN_00493 1.4e-69 glpQ1 3.1.4.46 C glycerophosphoryl diester phosphodiesterase
APENOPEN_00494 3.8e-117 czcD P cation diffusion facilitator family transporter
APENOPEN_00495 3.6e-96 sirR K iron dependent repressor
APENOPEN_00496 3.1e-64 thrE S Putative threonine/serine exporter
APENOPEN_00497 8.7e-33 S Threonine/Serine exporter, ThrE
APENOPEN_00498 7.4e-65 lssY 3.6.1.27 I phosphatase
APENOPEN_00499 1.1e-91 I alpha/beta hydrolase fold
APENOPEN_00500 6.4e-44 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
APENOPEN_00501 3.8e-26 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
APENOPEN_00504 7.9e-44 potC 2.1.1.172, 2.1.1.80, 3.1.1.61 J Ion channel
APENOPEN_00505 1.1e-165 rfbB 4.2.1.46 M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
APENOPEN_00506 7.9e-108 rfbC 5.1.3.13 M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
APENOPEN_00507 3.4e-107 rfbA 2.7.7.24 H Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
APENOPEN_00508 7.6e-08 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
APENOPEN_00509 2.3e-89 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
APENOPEN_00510 5.3e-20 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
APENOPEN_00511 7.7e-64 def 2.1.2.9, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
APENOPEN_00512 4.7e-166 proA 1.2.1.41 E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
APENOPEN_00513 5.1e-92 proB 2.7.2.11 F Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
APENOPEN_00514 3.9e-283 dxs 2.2.1.7 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
APENOPEN_00515 2.5e-172 N Uncharacterized conserved protein (DUF2075)
APENOPEN_00516 8e-46 S SNARE associated Golgi protein
APENOPEN_00517 1.8e-159 norA EGP Major facilitator Superfamily
APENOPEN_00518 1.4e-80 glpQ 3.1.4.46 C Membrane domain of glycerophosphoryl diester phosphodiesterase
APENOPEN_00519 8.7e-191 yjeM E Amino Acid
APENOPEN_00520 2e-21 crcB U Important for reducing fluoride concentration in the cell, thus reducing its toxicity
APENOPEN_00521 9e-20 crcB U Important for reducing fluoride concentration in the cell, thus reducing its toxicity
APENOPEN_00522 5e-50 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
APENOPEN_00523 7.6e-73 wecD3 K Acetyltransferase (GNAT) family
APENOPEN_00524 2.7e-121 tagE3 2.4.1.52 GT4 M Glycosyl transferases group 1
APENOPEN_00525 2.3e-167 tagE2 2.4.1.52 GT4 M Poly(Glycerol-phosphate) alpha-glucosyltransferase
APENOPEN_00526 2.6e-200 rumA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APENOPEN_00527 2e-181 brnQ U Component of the transport system for branched-chain amino acids
APENOPEN_00528 8.4e-57 nqr 1.5.1.36 S reductase
APENOPEN_00529 9e-141 XK27_09615 S reductase
APENOPEN_00530 2.3e-179 dltD M Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
APENOPEN_00531 2e-28 dltC 6.1.1.13 J Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
APENOPEN_00532 3.1e-191 dltB M MBOAT, membrane-bound O-acyltransferase family
APENOPEN_00533 9.7e-214 dltA 6.1.1.13 H Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
APENOPEN_00535 4.5e-120 P Belongs to the nlpA lipoprotein family
APENOPEN_00536 6.7e-82 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APENOPEN_00537 9e-54 F NUDIX domain
APENOPEN_00538 1.4e-111 EGP Major facilitator Superfamily
APENOPEN_00539 3.5e-192 rlmL 2.1.1.173, 2.1.1.264 L Belongs to the methyltransferase superfamily
APENOPEN_00540 2.7e-80 ypgQ S Metal dependent phosphohydrolases with conserved 'HD' motif.
APENOPEN_00541 6.7e-111 gspA M family 8
APENOPEN_00542 6.9e-73 ylbE GM NAD(P)H-binding
APENOPEN_00543 5.7e-83 S Alpha beta hydrolase
APENOPEN_00544 2.3e-74 K Acetyltransferase (GNAT) domain
APENOPEN_00545 5.1e-63 S Protein of unknown function (DUF2974)
APENOPEN_00546 4e-69 azlC E azaleucine resistance protein AzlC
APENOPEN_00547 2.1e-25 azlD E Branched-chain amino acid transport
APENOPEN_00548 6e-45 C Flavodoxin
APENOPEN_00549 9.7e-81
APENOPEN_00551 9.1e-123 IQ reductase
APENOPEN_00552 1.9e-19 S Domain of unknown function (DUF4767)
APENOPEN_00553 3.5e-173 potA 3.6.3.30, 3.6.3.31 P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
APENOPEN_00554 2.7e-122 potB P ABC transporter permease
APENOPEN_00555 2.9e-100 potC P ABC transporter permease
APENOPEN_00556 3.9e-161 potD P ABC transporter
APENOPEN_00557 1.9e-200 yfnA E Amino Acid
APENOPEN_00558 3.7e-59 apfA 2.7.7.72, 3.6.1.61 F Nudix hydrolase
APENOPEN_00559 9.8e-71 gmk2 2.7.4.8 F Guanylate kinase
APENOPEN_00560 1.2e-44 zur P Belongs to the Fur family
APENOPEN_00561 1.7e-09 3.2.1.14 GH18
APENOPEN_00562 1.1e-91
APENOPEN_00563 8.8e-87 yfeJ 6.3.5.2 F glutamine amidotransferase
APENOPEN_00564 1.2e-103 galM 5.1.3.3 G Catalyzes the interconversion of alpha and beta anomers of maltose
APENOPEN_00565 2.7e-52 K Transcriptional regulator (TetR family)
APENOPEN_00566 3.9e-70 tlpA2 L Transposase IS200 like
APENOPEN_00567 1.8e-205 L transposase, IS605 OrfB family
APENOPEN_00568 2.7e-38 rofA K M protein trans-acting positive regulator (MGA) PRD domain
APENOPEN_00569 3.1e-109 deoR K sugar-binding domain protein
APENOPEN_00570 6.2e-187 oxlT P Major Facilitator Superfamily
APENOPEN_00571 4.9e-44 yxeM ET Bacterial periplasmic substrate-binding proteins
APENOPEN_00573 2.9e-30 yxeN U ABC transporter, permease protein
APENOPEN_00574 2.9e-73 V Lanthionine synthetase C-like protein
APENOPEN_00575 4.7e-103 gldA 1.1.1.1, 1.1.1.6 C glycerol dehydrogenase
APENOPEN_00577 1.5e-148 ppaC 3.6.1.1 C inorganic pyrophosphatase
APENOPEN_00578 0.0 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
APENOPEN_00579 0.0 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
APENOPEN_00580 3e-154 hpk31 2.7.13.3 T Histidine kinase
APENOPEN_00581 6.6e-114 K response regulator
APENOPEN_00582 2.8e-15 yfjR K WYL domain
APENOPEN_00583 1e-07
APENOPEN_00584 2.9e-80 I Carboxylesterase family
APENOPEN_00585 3e-91 yagE E amino acid
APENOPEN_00586 8.4e-137 thiM 2.7.1.50 H Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
APENOPEN_00587 2.6e-141 thiD 2.5.1.3, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Phosphomethylpyrimidine kinase
APENOPEN_00588 1.6e-114 thiE 2.5.1.3 H thiamine-phosphate diphosphorylase activity
APENOPEN_00589 1.6e-123 tenA 3.5.99.2 K Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
APENOPEN_00590 1.1e-153 EGP Major facilitator Superfamily
APENOPEN_00592 1.4e-167 ycsG P Natural resistance-associated macrophage protein
APENOPEN_00593 9.7e-98 ycsF S LamB/YcsF family
APENOPEN_00594 6e-191 accC 6.3.4.14, 6.4.1.2 I Acetyl-CoA carboxylase biotin carboxylase subunit
APENOPEN_00595 1.9e-18 secA2 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
APENOPEN_00597 4.8e-177 asnA 6.3.1.1 F aspartate--ammonia ligase
APENOPEN_00599 1.5e-33 S Bacteriophage Mu Gam like protein
APENOPEN_00600 5.8e-83 S AAA domain
APENOPEN_00601 1.6e-32 S Protein of unknown function (DUF669)
APENOPEN_00602 4e-86 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APENOPEN_00603 3e-149 L Transposase and inactivated derivatives IS30 family
APENOPEN_00604 1.1e-55 pipD E Dipeptidase
APENOPEN_00605 2.9e-66 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
APENOPEN_00606 3.9e-123 pnuC H nicotinamide mononucleotide transporter
APENOPEN_00607 2.5e-102 thrB 2.7.1.39 F Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
APENOPEN_00608 1.5e-129 ydiN G Major Facilitator Superfamily
APENOPEN_00609 2e-10 aroK 1.1.1.25, 2.7.1.71, 5.4.99.5 E Chorismate mutase type II
APENOPEN_00610 1.4e-164 aroC 4.2.3.5 E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
APENOPEN_00611 5.8e-159 aroA 1.3.1.12, 1.3.1.43, 2.5.1.19 E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
APENOPEN_00612 3.1e-84 tyrA 1.3.1.12, 1.3.1.43 E prephenate dehydrogenase
APENOPEN_00613 4.2e-44 aroK 1.1.1.25, 2.7.1.71, 4.2.1.10, 4.2.3.4 F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APENOPEN_00615 4.7e-201 kgtP EGP Sugar (and other) transporter
APENOPEN_00616 1.1e-50 arsC 1.20.4.1 T Low molecular weight phosphotyrosine protein phosphatase
APENOPEN_00617 0.0 pacL 3.6.3.8 P P-type ATPase
APENOPEN_00618 9.4e-207 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
APENOPEN_00619 9.6e-187 glnP P ABC transporter
APENOPEN_00620 7.2e-122 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
APENOPEN_00621 1.5e-202 cycA E Amino acid permease
APENOPEN_00622 3.8e-140 E Arginine ornithine antiporter
APENOPEN_00623 2.1e-189 arcT 2.6.1.1 E Aminotransferase
APENOPEN_00624 1.7e-189 nupG F Nucleoside transporter
APENOPEN_00625 5.5e-148 rihC 3.2.2.1 F Nucleoside
APENOPEN_00626 1.2e-44 S Prophage endopeptidase tail
APENOPEN_00627 4.7e-200 rodA D Belongs to the SEDS family
APENOPEN_00628 1.1e-21 S Protein of unknown function (DUF2969)
APENOPEN_00629 5.8e-159 mbl D Cell shape determining protein MreB Mrl
APENOPEN_00630 5.8e-76 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APENOPEN_00631 1.4e-18 ywzB S Protein of unknown function (DUF1146)
APENOPEN_00632 8.4e-43 atpC C Produces ATP from ADP in the presence of a proton gradient across the membrane
APENOPEN_00633 2.3e-249 atpD 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
APENOPEN_00634 8.1e-115 atpG C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
APENOPEN_00635 3.3e-254 atpA 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
APENOPEN_00636 2.8e-67 atpH C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APENOPEN_00637 7.4e-49 atpF C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
APENOPEN_00638 2.9e-15 atpE C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APENOPEN_00639 4.2e-103 atpB C it plays a direct role in the translocation of protons across the membrane
APENOPEN_00640 2.1e-209 pyrP F Permease
APENOPEN_00641 1.4e-50 M1-874 K Domain of unknown function (DUF1836)
APENOPEN_00642 1.2e-49 1.14.14.47 GM epimerase
APENOPEN_00643 1.8e-92 ypdB V (ABC) transporter
APENOPEN_00644 9.1e-79 nusG K Participates in transcription elongation, termination and antitermination
APENOPEN_00645 2.2e-67 rplK J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
APENOPEN_00646 3.8e-109 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
APENOPEN_00647 1e-51 M Phage tail tape measure protein TP901
APENOPEN_00648 8.2e-61 K Transcriptional regulator, LacI family
APENOPEN_00649 8.2e-68 uvrX 2.7.7.7 L Belongs to the DNA polymerase type-Y family
APENOPEN_00650 3e-100 L Integrase
APENOPEN_00651 1.7e-286 aspS 6.1.1.12 J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
APENOPEN_00652 2.8e-198 hisS 6.1.1.21 J histidyl-tRNA synthetase
APENOPEN_00653 7.8e-96 lytH 3.5.1.28 M N-acetylmuramoyl-L-alanine amidase
APENOPEN_00654 4.5e-112 yniA G Phosphotransferase enzyme family
APENOPEN_00655 9.3e-61 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
APENOPEN_00656 0.0 relA 2.7.6.5 KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APENOPEN_00657 6e-11
APENOPEN_00658 3.8e-78 rsmE 2.1.1.193 J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
APENOPEN_00659 1.2e-134 prmA J Ribosomal protein L11 methyltransferase
APENOPEN_00660 4.5e-250 mglA 3.6.3.17 G ABC-type sugar transport system, ATPase component
APENOPEN_00661 9e-57 capM M Bacterial sugar transferase
APENOPEN_00662 5.4e-96 ywqE 3.1.3.48 GM PHP domain protein
APENOPEN_00663 2.2e-78 ywqD 2.7.10.1 D Capsular exopolysaccharide family
APENOPEN_00664 8.1e-85 epsB M biosynthesis protein
APENOPEN_00665 2.6e-122 brpA K Cell envelope-like function transcriptional attenuator common domain protein
APENOPEN_00667 1.2e-192 guaB 1.1.1.205 F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
APENOPEN_00668 2.5e-72 XK27_01040 S Protein of unknown function (DUF1129)
APENOPEN_00669 5.9e-189 ychF J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
APENOPEN_00670 4.6e-23 yyzM S Bacterial protein of unknown function (DUF951)
APENOPEN_00671 1.8e-100 spo0J K Belongs to the ParB family
APENOPEN_00672 2.4e-85 noc K Belongs to the ParB family
APENOPEN_00673 3.3e-103 rsmG 2.1.1.170 J Specifically methylates the N7 position of a guanine in 16S rRNA
APENOPEN_00674 2.8e-141 scrK 2.7.1.2, 2.7.1.4 GK ROK family
APENOPEN_00675 8.5e-57 G YdjC-like protein
APENOPEN_00676 5.6e-39 S Cytochrome B5
APENOPEN_00677 1.4e-95 1.1.1.193, 3.5.4.26 H RibD C-terminal domain
APENOPEN_00678 6.3e-48 yqkB S Belongs to the HesB IscA family
APENOPEN_00679 4.6e-42 K Transcriptional regulator
APENOPEN_00680 9.9e-98 bioY S BioY family
APENOPEN_00681 2.1e-82 prdE2 3.5.1.1 EJ Belongs to the asparaginase 1 family
APENOPEN_00682 1.6e-58 prdE2 3.5.1.1 EJ Belongs to the asparaginase 1 family
APENOPEN_00683 5.3e-174 yceI EGP Major facilitator Superfamily
APENOPEN_00684 1.2e-152 nadC 1.4.3.16, 2.4.2.19 H Quinolinate phosphoribosyl transferase, C-terminal domain
APENOPEN_00685 7.3e-133 mprF I Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
APENOPEN_00686 6.4e-153 cpoA GT4 M Glycosyltransferase, group 1 family protein
APENOPEN_00687 3.2e-172 mgs 2.4.1.337 GT4 M Glycosyltransferase, group 1 family protein
APENOPEN_00688 1.8e-184 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APENOPEN_00689 4.1e-35 ptsH G phosphocarrier protein HPR
APENOPEN_00690 9.7e-15
APENOPEN_00691 0.0 clpE O Belongs to the ClpA ClpB family
APENOPEN_00692 4.7e-55 S Pfam:DUF3816
APENOPEN_00693 1.6e-70 manA 1.14.13.81, 5.3.1.8, 5.4.2.8 G MucBP domain
APENOPEN_00694 4.6e-79 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
APENOPEN_00697 4.5e-187 galK 2.7.1.6 F Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
APENOPEN_00698 2.9e-228 galT 2.7.7.12 G UDP-glucose--hexose-1-phosphate uridylyltransferase
APENOPEN_00699 3.1e-104 galR K Transcriptional regulator
APENOPEN_00700 1.4e-59 XK27_02070 S Nitroreductase family
APENOPEN_00701 3.6e-62 msrB 1.8.4.11, 1.8.4.12 O peptide methionine sulfoxide reductase
APENOPEN_00702 0.0 rafA 3.2.1.22 G alpha-galactosidase
APENOPEN_00703 8.7e-276 lacS G Transporter
APENOPEN_00704 3.2e-86 lptB S ABC transporter, ATP-binding protein
APENOPEN_00705 1.8e-204 pcrA 3.6.4.12 L ATP-dependent DNA helicase
APENOPEN_00706 1.2e-299 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APENOPEN_00707 7.8e-144 camS S sex pheromone
APENOPEN_00708 3.8e-32 gatC 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APENOPEN_00709 3.2e-222 gatA 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
APENOPEN_00710 3.9e-241 gatB 6.1.1.12, 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APENOPEN_00711 3.2e-157 yegS 2.7.1.107 G Lipid kinase
APENOPEN_00712 1.6e-207 rumA 2.1.1.190 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APENOPEN_00714 1.2e-105 ahpC 1.11.1.15 O Peroxiredoxin
APENOPEN_00715 5e-83 sdaAA 4.3.1.17 E L-serine dehydratase, iron-sulfur-dependent, alpha subunit
APENOPEN_00717 2.2e-75 pva3 3.5.1.24 M Linear amide C-N hydrolase, choloylglycine hydrolase family protein
APENOPEN_00719 1.5e-37 S Bacteriophage Gp15 protein
APENOPEN_00720 4.6e-07
APENOPEN_00721 8e-32 N domain, Protein
APENOPEN_00722 2.4e-15 S Minor capsid protein from bacteriophage
APENOPEN_00723 1.4e-18 S Minor capsid protein
APENOPEN_00724 4.4e-29 S Minor capsid protein
APENOPEN_00725 8.6e-10
APENOPEN_00726 3.1e-103
APENOPEN_00727 2.8e-17 S Phage minor structural protein GP20
APENOPEN_00728 1.2e-83 S Phage minor capsid protein 2
APENOPEN_00729 2.3e-138 S Phage portal protein, SPP1 Gp6-like
APENOPEN_00730 2.8e-152 S Pfam:Terminase_3C
APENOPEN_00731 5.5e-253 ykgC 1.16.1.1, 1.8.1.7 C Pyridine nucleotide-disulfide oxidoreductase
APENOPEN_00732 1.3e-144 L PFAM Integrase catalytic region
APENOPEN_00733 5.7e-52 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APENOPEN_00734 2.1e-52 yqhY S Asp23 family, cell envelope-related function
APENOPEN_00735 5.6e-51 ybjI 3.1.3.102, 3.1.3.104, 3.1.3.23 S haloacid dehalogenase-like hydrolase
APENOPEN_00736 0.0 xfp 4.1.2.22, 4.1.2.9 G Phosphoketolase
APENOPEN_00737 1.7e-53 rcfA 4.1.99.16, 4.2.3.22, 4.2.3.75 K Transcriptional regulator, Crp Fnr family
APENOPEN_00738 1.1e-258 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APENOPEN_00739 2.3e-46 uspA T universal stress protein
APENOPEN_00740 1.1e-20
APENOPEN_00741 5.9e-13
APENOPEN_00742 8.9e-124
APENOPEN_00743 2.6e-52 K Transcriptional regulator
APENOPEN_00744 1.3e-131 D Alpha beta
APENOPEN_00745 1.5e-63 hxlB 4.1.2.14, 4.1.2.43, 4.1.3.42, 5.3.1.27 M sugar phosphate isomerase involved in capsule formation
APENOPEN_00746 1.2e-61 hxlA 4.1.2.43 G Orotidine 5'-phosphate decarboxylase HUMPS family
APENOPEN_00747 2.3e-144 kdgK 2.7.1.45 G pfkB family carbohydrate kinase
APENOPEN_00748 4.8e-182 gntT EG Citrate transporter
APENOPEN_00749 6.6e-91 kguE 2.7.1.45 G Xylose isomerase domain protein TIM barrel
APENOPEN_00750 5e-14
APENOPEN_00751 1.7e-73 kdgR K helix_turn _helix lactose operon repressor
APENOPEN_00752 1.1e-19 yvlA
APENOPEN_00753 1.8e-108 P transmembrane transporter activity
APENOPEN_00754 3.9e-254 cbiO1 S ABC transporter
APENOPEN_00755 1.1e-104 S ABC-type cobalt transport system, permease component
APENOPEN_00756 6.5e-190 hemH 4.99.1.1, 4.99.1.9 H Catalyzes the ferrous insertion into protoporphyrin IX
APENOPEN_00757 1.2e-158 iunH2 3.2.2.1 F nucleoside hydrolase
APENOPEN_00758 1.3e-134 yumC 1.18.1.2, 1.19.1.1, 1.8.1.9 C Ferredoxin--NADP reductase
APENOPEN_00759 5.2e-40 ybjQ S Belongs to the UPF0145 family
APENOPEN_00760 6.8e-71 C Nitroreductase family
APENOPEN_00761 0.0 ltaS 2.7.8.20 M Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
APENOPEN_00762 3.2e-24
APENOPEN_00763 1.3e-95 pgm3 G phosphoglycerate mutase family
APENOPEN_00764 4.2e-203 pipD E Dipeptidase
APENOPEN_00765 2.1e-191 pbuX F xanthine permease
APENOPEN_00766 6.6e-141 corA P CorA-like Mg2+ transporter protein
APENOPEN_00767 7.5e-97 rluA 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
APENOPEN_00768 2.8e-100 terC P membrane
APENOPEN_00769 7e-42 trxA1 O Belongs to the thioredoxin family
APENOPEN_00770 3.9e-133 rbsK 2.7.1.15 H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APENOPEN_00771 1.1e-63 rbsD 5.4.99.62 G Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose
APENOPEN_00772 1.1e-197 fucP G Major Facilitator Superfamily
APENOPEN_00773 6.5e-144 amtB P ammonium transporter
APENOPEN_00774 3.6e-172 mepA V MATE efflux family protein
APENOPEN_00775 6e-34 K Transcriptional regulators
APENOPEN_00776 4.1e-12
APENOPEN_00778 2.9e-182 gap 1.2.1.12 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
APENOPEN_00779 2e-206 pgk 2.7.2.3, 5.3.1.1 F Belongs to the phosphoglycerate kinase family
APENOPEN_00780 1.5e-103 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
APENOPEN_00781 4.5e-244 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
APENOPEN_00782 1.7e-205 clcA P chloride
APENOPEN_00783 2.5e-31 secG U Preprotein translocase
APENOPEN_00784 0.0 rnr J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
APENOPEN_00785 3.1e-70 smpB J the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
APENOPEN_00786 3.4e-56 yxjI
APENOPEN_00787 5.6e-116 ung 3.2.2.27 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
APENOPEN_00788 6.7e-144 pta 2.3.1.8, 3.6.3.21 C phosphate acetyltransferase
APENOPEN_00789 3.4e-61 ydiB 2.7.1.221, 5.1.1.1 O Hydrolase, P-loop family
APENOPEN_00790 7.4e-41 K Acetyltransferase (GNAT) domain
APENOPEN_00791 1.3e-105 lacR K Transcriptional regulator
APENOPEN_00792 9.7e-235 lacS G Transporter
APENOPEN_00793 1.1e-305 lacZ 3.2.1.23 G -beta-galactosidase
APENOPEN_00794 1.6e-75 dnaQ 2.7.7.7 L DNA polymerase III
APENOPEN_00795 2.1e-108 xth 3.1.11.2 L exodeoxyribonuclease III
APENOPEN_00796 9.3e-132 murB 1.3.1.98 M Cell wall formation
APENOPEN_00797 2.7e-64 S Protein of unknown function (DUF1361)
APENOPEN_00798 1.5e-123 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
APENOPEN_00799 5.5e-76 ybbR S YbbR-like protein
APENOPEN_00800 9.1e-224 glmM 5.4.2.10 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APENOPEN_00801 4.7e-284 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
APENOPEN_00802 7.4e-44
APENOPEN_00803 2.8e-236 oatA I Acyltransferase
APENOPEN_00804 7.7e-101 XK27_02985 S Sucrose-6F-phosphate phosphohydrolase
APENOPEN_00805 6.6e-54 lytE M Lysin motif
APENOPEN_00806 1.7e-108 brpA K Cell envelope-like function transcriptional attenuator common domain protein
APENOPEN_00807 1.7e-121 MA20_14895 S Conserved hypothetical protein 698
APENOPEN_00808 6.2e-64 K LysR substrate binding domain
APENOPEN_00809 2.8e-176 iscS 2.8.1.7 E Aminotransferase class V
APENOPEN_00811 1.7e-119 S Phosphotransferase system, EIIC
APENOPEN_00813 1.7e-205 S membrane
APENOPEN_00814 1.3e-107 L hmm pf00665
APENOPEN_00815 3e-161 S Uncharacterized protein conserved in bacteria (DUF2252)
APENOPEN_00816 1.6e-197 scrB 3.2.1.26 GH32 G invertase
APENOPEN_00817 1.2e-39 elaA S Gnat family
APENOPEN_00818 1.3e-164 adhA 1.1.1.1 C Zinc-binding alcohol dehydrogenase family protein
APENOPEN_00819 5.1e-268 scrA 2.7.1.211, 5.3.1.1 G phosphotransferase system
APENOPEN_00820 6.8e-83 ppiB 5.2.1.8 G PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APENOPEN_00821 1e-238 fumC 4.2.1.2 C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
APENOPEN_00822 3.2e-208 frdC 1.3.5.4 C FAD binding domain
APENOPEN_00823 4.3e-108 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
APENOPEN_00824 1.6e-178 P Sodium:sulfate symporter transmembrane region
APENOPEN_00825 1.2e-79 ydjP I Alpha/beta hydrolase family
APENOPEN_00826 2.4e-106 citR K sugar-binding domain protein
APENOPEN_00827 4.7e-144 mez_1 1.1.1.38 C Malic enzyme, NAD binding domain
APENOPEN_00828 2.1e-138 citC 6.2.1.22 H Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
APENOPEN_00829 1.1e-33 citD C Covalent carrier of the coenzyme of citrate lyase
APENOPEN_00830 1.1e-143 citE 4.1.3.25, 4.1.3.34 G Belongs to the HpcH HpaI aldolase family
APENOPEN_00831 3.2e-249 citF 2.8.3.10 H Citrate (pro-3S)-lyase alpha chain
APENOPEN_00832 2.7e-91 citG 2.4.2.52, 2.7.7.61 H 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase
APENOPEN_00833 3.5e-91 mleR K LysR family transcriptional regulator
APENOPEN_00834 2.4e-187 yjjP S Putative threonine/serine exporter
APENOPEN_00835 4.7e-72 ung2 3.2.2.27 L Uracil-DNA glycosylase
APENOPEN_00836 2e-87 I Alpha beta
APENOPEN_00837 8.5e-70 thiJ 2.7.11.1, 3.5.1.124 S DJ-1/PfpI family
APENOPEN_00838 1.4e-158 L hmm pf00665
APENOPEN_00839 5e-49 L Helix-turn-helix domain
APENOPEN_00840 3.2e-205 gabT 2.6.1.19 E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
APENOPEN_00841 6.9e-222 yfnA E amino acid
APENOPEN_00842 0.0 mprF 2.3.2.3 S Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
APENOPEN_00844 7.2e-113 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 J Responsible for synthesis of pseudouridine from uracil
APENOPEN_00845 1.1e-83 luxS 4.4.1.21 H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
APENOPEN_00846 2.3e-56 S Domain of unknown function (DUF4811)
APENOPEN_00847 4e-204 lmrB EGP Major facilitator Superfamily
APENOPEN_00848 7.6e-34 merR K MerR HTH family regulatory protein
APENOPEN_00849 1.2e-18
APENOPEN_00850 3.7e-76 patA 2.6.1.1 E Aminotransferase
APENOPEN_00851 6.5e-165 ldhD 1.1.1.28 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APENOPEN_00852 5e-75 osmC O OsmC-like protein
APENOPEN_00853 6.4e-251 XK27_08315 M Sulfatase
APENOPEN_00854 3.8e-35 K Transcriptional regulator
APENOPEN_00855 9.2e-78 rlmH 2.1.1.177 J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
APENOPEN_00856 2.1e-134 htrA 3.4.21.107 O serine protease
APENOPEN_00857 6.2e-119 vicX 3.1.26.11 S domain protein
APENOPEN_00858 1.3e-76 yycI S YycH protein
APENOPEN_00859 5.9e-103 yycH S YycH protein
APENOPEN_00860 4.8e-292 vicK 2.7.13.3 T Histidine kinase
APENOPEN_00861 2.2e-120 K response regulator
APENOPEN_00864 2.5e-36
APENOPEN_00865 2.3e-138 lmrP E Major Facilitator Superfamily
APENOPEN_00866 1.6e-178 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
APENOPEN_00867 2.5e-56 rplI J Binds to the 23S rRNA
APENOPEN_00868 2.1e-277 yybT T signaling protein consisting of a modified GGDEF domain and a DHH domain
APENOPEN_00869 6.2e-35 rpsR J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
APENOPEN_00870 1.7e-46 ssb L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
APENOPEN_00871 2.4e-44 rpsF J Binds together with S18 to 16S ribosomal RNA
APENOPEN_00872 0.0 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APENOPEN_00873 0.0 gyrB 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APENOPEN_00874 4.3e-142 recF L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APENOPEN_00875 1.6e-19 yaaA S S4 domain protein YaaA
APENOPEN_00876 1.2e-147 dnaN 2.7.7.7 L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
APENOPEN_00877 2e-167 dnaA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APENOPEN_00878 3.4e-14 rpmH J Belongs to the bacterial ribosomal protein bL34 family
APENOPEN_00879 9.9e-50 rnpA 3.1.26.5 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
APENOPEN_00880 2.1e-114 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
APENOPEN_00881 7.4e-64 jag S R3H domain protein
APENOPEN_00882 6.1e-223 mnmE S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
APENOPEN_00883 0.0 gidA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
APENOPEN_00884 2.4e-191 yxbA 6.3.1.12 S ATP-grasp enzyme
APENOPEN_00885 0.0 asnB 6.3.5.4 E Asparagine synthase
APENOPEN_00886 3.8e-186 murE 6.3.2.13, 6.3.2.7 M Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APENOPEN_00887 3.6e-212 xylT EGP Major facilitator Superfamily
APENOPEN_00888 2.5e-245 xylA 5.3.1.5 G Belongs to the xylose isomerase family
APENOPEN_00889 1e-263 xylB 2.7.1.12, 2.7.1.17 G Xylulose kinase
APENOPEN_00890 4.5e-110 K helix_turn_helix, arabinose operon control protein
APENOPEN_00891 2.8e-250 xynT G MFS/sugar transport protein
APENOPEN_00892 0.0 3.2.1.55 GH51 G Right handed beta helix region
APENOPEN_00893 1.3e-75 KT Purine catabolism regulatory protein-like family
APENOPEN_00894 6.1e-204 XK27_08635 S UPF0210 protein
APENOPEN_00895 1.4e-27 gcvR T Belongs to the UPF0237 family
APENOPEN_00896 3.5e-13
APENOPEN_00897 3.5e-185 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
APENOPEN_00898 3.9e-128 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
APENOPEN_00899 1.6e-100 puuD S peptidase C26
APENOPEN_00900 2e-202 gshF 6.3.2.2 H Belongs to the glutamate--cysteine ligase type 1 family
APENOPEN_00901 9.8e-38 mscL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
APENOPEN_00903 4.9e-78 V AAA domain, putative AbiEii toxin, Type IV TA system
APENOPEN_00904 4.1e-92 V ABC-type multidrug transport system, permease component
APENOPEN_00905 2.1e-29 K Transcriptional regulator
APENOPEN_00906 7.1e-159 mdtG EGP Major facilitator Superfamily
APENOPEN_00907 3.8e-161 EGP Major facilitator Superfamily
APENOPEN_00908 1.2e-109 T Calcineurin-like phosphoesterase superfamily domain
APENOPEN_00909 5.8e-37 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APENOPEN_00910 2.8e-84 pts13C G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
APENOPEN_00911 1.8e-98 S Alpha/beta hydrolase of unknown function (DUF915)
APENOPEN_00913 1.1e-114 ecsB U ABC transporter
APENOPEN_00914 1e-107 ecsA V ABC transporter, ATP-binding protein
APENOPEN_00915 1.1e-61 hit FG histidine triad
APENOPEN_00917 7.9e-121 prsA 5.2.1.8 M Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins
APENOPEN_00918 2.2e-110 yhaM S Metal dependent phosphohydrolases with conserved 'HD' motif.
APENOPEN_00919 8.1e-21 yheA S Belongs to the UPF0342 family
APENOPEN_00920 3.9e-290 pbp2A 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
APENOPEN_00921 9.5e-263 argS 6.1.1.19 J Arginyl-tRNA synthetase
APENOPEN_00922 1.2e-221 cydA 1.10.3.14 C ubiquinol oxidase
APENOPEN_00923 3.7e-137 cydB 1.10.3.14 C Cytochrome d ubiquinol oxidase subunit II
APENOPEN_00924 4.1e-213 cydD CO ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydD
APENOPEN_00925 5.4e-208 cydD CO ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
APENOPEN_00926 7.2e-93 hepT 2.5.1.30, 2.5.1.90 H Belongs to the FPP GGPP synthase family
APENOPEN_00927 4.5e-102 menA 2.5.1.74 H 1,4-dihydroxy-2-naphthoate
APENOPEN_00928 1.1e-138 ndh 1.6.99.3 C NADH dehydrogenase
APENOPEN_00929 1.3e-263 glgB 2.4.1.18, 3.2.1.141, 3.2.1.20 CBM48,GH13,GH31 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APENOPEN_00930 1.6e-165 glgC 2.7.7.27 H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APENOPEN_00931 4.2e-108 glgD 2.4.1.21, 2.7.7.27 GT5 G Nucleotidyl transferase
APENOPEN_00932 9e-206 glgA 2.4.1.21 GT5 F Synthesizes alpha-1,4-glucan chains using ADP-glucose
APENOPEN_00933 4e-307 glgP 2.4.1.1 GT35 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
APENOPEN_00934 6.8e-280 carB 6.3.5.5 F Carbamoyl-phosphate synthase
APENOPEN_00935 1.3e-145 adhB 1.1.1.1, 1.1.1.14 E alcohol dehydrogenase
APENOPEN_00936 7.9e-38 rnhA 3.1.26.4 L Ribonuclease HI
APENOPEN_00937 4.4e-41 esbA S Family of unknown function (DUF5322)
APENOPEN_00938 2.4e-44 lspA 3.4.23.36 MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APENOPEN_00939 3e-146 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
APENOPEN_00940 2e-168 carA 6.3.5.5 F Belongs to the CarA family
APENOPEN_00941 1.6e-242 carB 6.3.5.5 F Carbamoyl-phosphate synthase
APENOPEN_00942 4.9e-22 K GNAT family
APENOPEN_00943 8.8e-111 pepI 3.4.11.5, 3.5.1.101 E Releases the N-terminal proline from various substrates
APENOPEN_00944 1e-20 yefM 2.3.1.15 D Antitoxin component of a toxin-antitoxin (TA) module
APENOPEN_00945 1.3e-25 S YoeB-like toxin of bacterial type II toxin-antitoxin system
APENOPEN_00946 2e-243 tetP J elongation factor G
APENOPEN_00947 2.2e-147 S Aldo keto reductase
APENOPEN_00948 9.5e-89 ypjC S Uncharacterised 5xTM membrane BCR, YitT family COG1284
APENOPEN_00949 4.8e-39 S Alpha/beta hydrolase of unknown function (DUF915)
APENOPEN_00950 7.5e-52 racA K Domain of unknown function (DUF1836)
APENOPEN_00951 7.3e-70 yitS S EDD domain protein, DegV family
APENOPEN_00952 1.3e-102 yibF S overlaps another CDS with the same product name
APENOPEN_00953 5e-119 yibE S overlaps another CDS with the same product name
APENOPEN_00954 2.9e-103 upp 2.4.2.9 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
APENOPEN_00955 1.2e-143 ywlC 2.7.7.87, 3.1.3.48 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
APENOPEN_00956 9.2e-113 prmB 2.1.1.297, 2.1.1.298 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
APENOPEN_00957 1.3e-183 prfA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
APENOPEN_00958 4.1e-96 tdk 2.7.1.21 F thymidine kinase
APENOPEN_00959 2.8e-225 murD 3.4.21.10, 6.3.2.13, 6.3.2.9 M Mur ligase, middle domain
APENOPEN_00960 1.9e-119 cobQ S CobB/CobQ-like glutamine amidotransferase domain
APENOPEN_00961 4.5e-17
APENOPEN_00962 3.4e-42 K Transcriptional regulator
APENOPEN_00963 1.3e-110 1.1.1.1 C nadph quinone reductase
APENOPEN_00964 1.2e-29 I TAP-like protein
APENOPEN_00965 1.3e-47 I TAP-like protein
APENOPEN_00966 1.3e-161 C aldo keto reductase
APENOPEN_00967 7.6e-57 ywrO S Flavodoxin-like fold
APENOPEN_00968 5.3e-50 adhR K helix_turn_helix, mercury resistance
APENOPEN_00969 1.5e-85 gyaR 1.1.1.26 CH D-isomer specific 2-hydroxyacid dehydrogenase
APENOPEN_00970 1e-159 G Major Facilitator Superfamily
APENOPEN_00971 3.4e-54 K Acetyltransferase (GNAT) family
APENOPEN_00972 7.5e-58 VY92_08705 S DJ-1/PfpI family
APENOPEN_00973 8.8e-20
APENOPEN_00974 2.8e-95 recX 2.4.1.337 GT4 S Regulatory protein RecX
APENOPEN_00975 7.9e-105 yihY S Belongs to the UPF0761 family
APENOPEN_00976 1.5e-142 map 3.4.11.18 E Methionine Aminopeptidase
APENOPEN_00977 1.8e-62 fld C Flavodoxin
APENOPEN_00978 2.4e-56 gtcA S Teichoic acid glycosylation protein
APENOPEN_00980 2.4e-160 yfmL L DEAD DEAH box helicase
APENOPEN_00981 1.4e-155 mocA S Oxidoreductase
APENOPEN_00982 1.1e-49 S Domain of unknown function (DUF4828)
APENOPEN_00983 6.9e-91 L Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
APENOPEN_00984 1.2e-81 mnaA 5.1.3.14 M UDP-N-acetylglucosamine 2-epimerase
APENOPEN_00985 1.9e-137 G Glycosyl hydrolases family 8
APENOPEN_00986 1.7e-190 ydaM M Glycosyl transferase family group 2
APENOPEN_00988 2.5e-65
APENOPEN_00989 2.1e-176 aadAT EK Aminotransferase, class I
APENOPEN_00990 4e-09
APENOPEN_00991 2.9e-189 gntK 2.7.1.12, 2.7.1.17 G Belongs to the FGGY kinase family
APENOPEN_00992 1e-60 S Alpha/beta hydrolase of unknown function (DUF915)
APENOPEN_00993 1.2e-58 yvdD 3.2.2.10 S Belongs to the LOG family
APENOPEN_00994 3.6e-86 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
APENOPEN_00995 1.2e-152 gshF 6.3.2.2 H Belongs to the glutamate--cysteine ligase type 1 family
APENOPEN_00996 5.9e-37 yneR S Belongs to the HesB IscA family
APENOPEN_00997 1.3e-116 EGP Major facilitator Superfamily
APENOPEN_00998 2.9e-245 asnB 6.3.5.4 E Aluminium induced protein
APENOPEN_00999 7.4e-102 yjbM 2.7.6.5 S RelA SpoT domain protein
APENOPEN_01000 5e-108 nadK 2.7.1.23 F Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
APENOPEN_01001 1.6e-115 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 G Responsible for synthesis of pseudouridine from uracil
APENOPEN_01002 1.1e-149 pgl 3.1.1.31 G Lactonase, 7-bladed beta-propeller
APENOPEN_01003 4.3e-94 rrmA 2.1.1.187 H Methyltransferase
APENOPEN_01004 1.5e-81 trmL 2.1.1.207 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
APENOPEN_01005 1.2e-260 ftsK D Belongs to the FtsK SpoIIIE SftA family
APENOPEN_01006 8.4e-09 S Protein of unknown function (DUF4044)
APENOPEN_01007 1.2e-18
APENOPEN_01008 7e-53 mraZ K Belongs to the MraZ family
APENOPEN_01009 5.5e-135 rsmH 2.1.1.199 J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
APENOPEN_01010 1.2e-16 ftsL D Cell division protein FtsL
APENOPEN_01011 4.6e-246 ftsI 3.4.16.4 M Penicillin-binding Protein
APENOPEN_01012 7.1e-146 mraY 2.7.8.13 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APENOPEN_01013 1.3e-217 murD 6.3.2.9 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
APENOPEN_01014 3.5e-165 murG 2.4.1.227, 6.3.2.8 GT28 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
APENOPEN_01015 2.7e-242 sufB O assembly protein SufB
APENOPEN_01016 8.3e-120 sufD O FeS assembly protein SufD
APENOPEN_01017 1.3e-195 L Probable transposase
APENOPEN_01018 2.5e-109 sufC O FeS assembly ATPase SufC
APENOPEN_01019 2.2e-102 nrdG 1.97.1.4 O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APENOPEN_01020 0.0 nrdD 1.1.98.6 F Ribonucleoside-triphosphate reductase
APENOPEN_01024 1.6e-149 clpB O Belongs to the ClpA ClpB family
APENOPEN_01027 2.4e-143 topA2 5.99.1.2 G Topoisomerase IA
APENOPEN_01028 2.2e-130 mnaA 5.1.3.14 G Belongs to the UDP-N-acetylglucosamine 2-epimerase family
APENOPEN_01030 1.2e-163 M Glycosyl transferase family group 2
APENOPEN_01032 6e-83 S Protein of unknown function (DUF554)
APENOPEN_01033 1.1e-216 pipD E Dipeptidase
APENOPEN_01034 1.4e-214 yjbQ P TrkA C-terminal domain protein
APENOPEN_01036 1.1e-82 K Transcriptional regulatory protein, C terminal
APENOPEN_01037 4.7e-95 T PhoQ Sensor
APENOPEN_01038 1.1e-14 dedA S SNARE-like domain protein
APENOPEN_01039 6.1e-23 ykoT GT2 M Glycosyl transferase family 2
APENOPEN_01040 3.9e-71 ykoT GT2 M Glycosyl transferase family 2
APENOPEN_01041 2.2e-122 M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
APENOPEN_01042 3.6e-184 yjcE P Sodium proton antiporter
APENOPEN_01043 3.3e-98 tal 2.2.1.2 H Transaldolase/Fructose-6-phosphate aldolase
APENOPEN_01044 8.8e-239 tkt 2.2.1.1 H Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
APENOPEN_01045 4.9e-100 rpsD J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
APENOPEN_01046 1.7e-44 ytsP 1.8.4.14 T GAF domain-containing protein
APENOPEN_01047 4.7e-116 ezrA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
APENOPEN_01048 9.6e-174 iscS2 2.8.1.7 E Aminotransferase class V
APENOPEN_01050 9.9e-213 cas9 L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
APENOPEN_01051 2.4e-10
APENOPEN_01052 6.4e-184 2.1.1.72 L DNA methylase
APENOPEN_01053 2.8e-19 3.1.21.5 KL Type III restriction enzyme res subunit
APENOPEN_01054 2.3e-242 U TraM recognition site of TraD and TraG
APENOPEN_01055 3.6e-86
APENOPEN_01057 3.8e-32
APENOPEN_01058 2.1e-131 ylqF S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
APENOPEN_01059 6.6e-102 rnhB 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APENOPEN_01060 1e-79 dprA LU DNA protecting protein DprA
APENOPEN_01061 0.0 topA 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
APENOPEN_01062 1.9e-105 lacX 5.1.3.3 G Aldose 1-epimerase
APENOPEN_01063 1.1e-112 IQ Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
APENOPEN_01064 1.5e-72 plsY 2.3.1.15, 3.5.1.104 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
APENOPEN_01065 8.3e-35 L Belongs to the 'phage' integrase family
APENOPEN_01066 1.6e-53 rplS J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
APENOPEN_01068 8.8e-225 yfnA E amino acid
APENOPEN_01069 1.1e-120 trmD 2.1.1.228, 4.6.1.12 J Belongs to the RNA methyltransferase TrmD family
APENOPEN_01070 2.9e-66 rimM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
APENOPEN_01071 1.7e-30 ylqC S Belongs to the UPF0109 family
APENOPEN_01072 2.8e-42 rpsP J Belongs to the bacterial ribosomal protein bS16 family
APENOPEN_01073 2.7e-20
APENOPEN_01074 4.2e-89 V ABC transporter, ATP-binding protein
APENOPEN_01075 9.7e-46 gntR1 K Transcriptional regulator, GntR family
APENOPEN_01076 1.1e-214 ffh 3.6.5.4 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APENOPEN_01077 1.8e-43 ylxM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
APENOPEN_01078 1.2e-149 ftsY U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
APENOPEN_01079 5e-237 smc D Required for chromosome condensation and partitioning
APENOPEN_01080 8.9e-117 rnc 3.1.26.3 J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
APENOPEN_01081 1.6e-33 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
APENOPEN_01082 1.3e-148 plsX 2.3.1.15 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
APENOPEN_01083 9.9e-299 recG 3.6.4.12 L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APENOPEN_01084 5.8e-244 yloV S DAK2 domain fusion protein YloV
APENOPEN_01085 7.3e-51 asp S Asp23 family, cell envelope-related function
APENOPEN_01086 2.3e-24 rpmB J Belongs to the bacterial ribosomal protein bL28 family
APENOPEN_01087 7e-71 thiN 2.7.6.2 H thiamine pyrophosphokinase
APENOPEN_01088 4.9e-98 rpe 5.1.3.1 G Belongs to the ribulose-phosphate 3-epimerase family
APENOPEN_01089 7.9e-120 rsgA 3.1.3.100 S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
APENOPEN_01090 6.9e-233 KLT serine threonine protein kinase
APENOPEN_01091 1.5e-79 stp 3.1.3.16 T phosphatase
APENOPEN_01092 3.1e-163 sun 2.1.1.176 J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APENOPEN_01093 9.2e-138 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
APENOPEN_01094 0.0 priA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
APENOPEN_01095 3.2e-127 coaBC 4.1.1.36, 6.3.2.5 H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APENOPEN_01096 3.7e-29 rpoZ 2.7.7.6 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
APENOPEN_01097 1.2e-66 gmk 2.7.4.8 F Essential for recycling GMP and indirectly, cGMP
APENOPEN_01098 6e-99 rpiA 2.7.1.12, 5.3.1.6 G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
APENOPEN_01099 4.6e-27 HA62_12640 S GCN5-related N-acetyl-transferase
APENOPEN_01100 3.4e-73 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F dUTP diphosphatase
APENOPEN_01101 5.1e-222 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
APENOPEN_01102 7.7e-150 yacL S domain protein
APENOPEN_01103 3e-244 gltX 6.1.1.17, 6.1.1.24 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APENOPEN_01104 2.3e-33 3.6.1.27 I Acid phosphatase homologues
APENOPEN_01105 0.0 rpoB 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APENOPEN_01106 0.0 rpoC 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APENOPEN_01107 8.3e-31 thiI 2.8.1.4 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APENOPEN_01108 7.7e-59 tpx 1.11.1.15 O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
APENOPEN_01109 0.0 valS 6.1.1.9 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
APENOPEN_01110 3.7e-161 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
APENOPEN_01111 2.6e-51 radC L DNA repair protein
APENOPEN_01112 1.4e-169 mreB D cell shape determining protein MreB
APENOPEN_01113 3.3e-260 L Transposase
APENOPEN_01114 1.4e-120 ampC V Beta-lactamase
APENOPEN_01115 1.9e-78 metAA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to
APENOPEN_01116 4.1e-267 yfiC V ABC transporter
APENOPEN_01117 1.4e-237 lmrA V ABC transporter, ATP-binding protein
APENOPEN_01118 9.2e-19 K Winged helix DNA-binding domain
APENOPEN_01119 2.1e-26 M domain protein
APENOPEN_01120 1.7e-09 bamA UW LPXTG-motif cell wall anchor domain protein
APENOPEN_01122 1.5e-07 atl 3.2.1.96, 3.5.1.28 GH73 UW LPXTG-motif cell wall anchor domain protein
APENOPEN_01123 5.3e-60 ypdB V (ABC) transporter
APENOPEN_01124 2.8e-48 1.14.14.47, 1.6.5.3, 1.6.99.3 GM epimerase
APENOPEN_01125 1.4e-44 M1-874 K Domain of unknown function (DUF1836)
APENOPEN_01126 7.5e-112 3.2.1.52 GH20 G Xylose isomerase domain protein TIM barrel
APENOPEN_01127 1.3e-113 nhaC C Na H antiporter NhaC
APENOPEN_01128 1.3e-244 pipD E Dipeptidase
APENOPEN_01129 7.1e-53
APENOPEN_01130 1.3e-69 ybaK J Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APENOPEN_01131 5.1e-84 pyrE 2.4.2.10, 4.1.1.23 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APENOPEN_01132 1e-104 pyrF 4.1.1.23 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
APENOPEN_01133 2.7e-131 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
APENOPEN_01134 5.4e-87 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
APENOPEN_01135 3.9e-216 purA 6.3.4.4 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
APENOPEN_01136 3.1e-173 guaC 1.1.1.205, 1.7.1.7 F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
APENOPEN_01137 9e-146 arcC 2.7.2.2 E Belongs to the carbamate kinase family
APENOPEN_01138 5.8e-169 argF 2.1.3.3 E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APENOPEN_01139 8.1e-95 sbcC L Putative exonuclease SbcCD, C subunit
APENOPEN_01140 5.4e-205 serS 6.1.1.11 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
APENOPEN_01141 5.1e-122 yttB EGP Major facilitator Superfamily
APENOPEN_01142 2.4e-148 aaxC E Amino acid permease
APENOPEN_01143 5.5e-26 trpS 6.1.1.2 J Belongs to the class-I aminoacyl-tRNA synthetase family
APENOPEN_01144 1.6e-90 trpS 6.1.1.2 J Belongs to the class-I aminoacyl-tRNA synthetase family
APENOPEN_01145 4.5e-82 S Phage tail protein
APENOPEN_01146 3.4e-133 Z012_10445 D Phage tail tape measure protein
APENOPEN_01147 6.4e-25
APENOPEN_01148 4.1e-29 S Pfam:Phage_TAC_12
APENOPEN_01149 1.6e-55 S Phage major tail protein 2
APENOPEN_01150 9.9e-135 aroF 2.5.1.54 E DAHP synthetase I family
APENOPEN_01151 2.3e-121 aroB 2.7.1.71, 4.2.3.4 E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APENOPEN_01152 1.7e-117 xylR GK ROK family
APENOPEN_01153 5.4e-121 glcU U sugar transport
APENOPEN_01154 6.2e-181 yclK 2.7.13.3 T Histidine kinase
APENOPEN_01155 7.8e-105 K response regulator
APENOPEN_01157 9.1e-33 infA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
APENOPEN_01158 1.1e-11 rpmJ J Belongs to the bacterial ribosomal protein bL36 family
APENOPEN_01159 1.2e-53 rpsM J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APENOPEN_01160 6.8e-63 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APENOPEN_01161 1.1e-154 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APENOPEN_01162 5.5e-57 rplQ J Ribosomal protein L17
APENOPEN_01163 2.4e-78 ecfA1 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
APENOPEN_01164 6.4e-77 ecfA2 3.6.3.55 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
APENOPEN_01165 2.1e-82 ecfT U Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
APENOPEN_01166 2.4e-115 truA 5.4.99.12 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
APENOPEN_01167 8e-68 rplM J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
APENOPEN_01168 9e-63 rpsI J Belongs to the universal ribosomal protein uS9 family
APENOPEN_01169 1.9e-10 M Glycosyl hydrolases family 25
APENOPEN_01170 2.6e-12 stfR M Phage Tail Collar Domain
APENOPEN_01171 1.7e-12
APENOPEN_01173 2.5e-25
APENOPEN_01175 6.1e-12
APENOPEN_01179 2e-17 S Bacteriophage holin of superfamily 6 (Holin_LLH)
APENOPEN_01180 4.8e-154 ps461 3.5.1.104 M hydrolase, family 25
APENOPEN_01182 9.9e-98 clpP 3.4.21.92 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
APENOPEN_01183 1.7e-144 whiA K May be required for sporulation
APENOPEN_01184 9.5e-154 ybhK S Required for morphogenesis under gluconeogenic growth conditions
APENOPEN_01185 2.1e-120 rapZ S Displays ATPase and GTPase activities
APENOPEN_01186 7.2e-69 aroD 1.1.1.25, 4.2.1.10 E Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
APENOPEN_01187 1.7e-128 aroE 1.1.1.25, 1.1.1.282, 1.3.5.4 E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APENOPEN_01188 0.0 uvrA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
APENOPEN_01189 0.0 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
APENOPEN_01190 8.2e-27 hadL 3.8.1.2 S Haloacid dehalogenase-like hydrolase
APENOPEN_01194 2.4e-102 yfbR S HD containing hydrolase-like enzyme
APENOPEN_01195 2.4e-293 pgm 5.4.2.2, 5.4.2.8 G Phosphoglucomutase phosphomannomutase, alpha beta alpha domain
APENOPEN_01196 4.2e-51 cof S haloacid dehalogenase-like hydrolase
APENOPEN_01197 1.1e-140 hicD2 1.1.1.27 C Belongs to the LDH MDH superfamily
APENOPEN_01198 1.3e-136 trxB 1.8.1.9 C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
APENOPEN_01199 9e-159 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
APENOPEN_01200 3e-155 gpsA 1.1.1.94 I Glycerol-3-phosphate dehydrogenase
APENOPEN_01201 2.8e-114 lgt 2.1.1.199 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
APENOPEN_01202 6.5e-147 hprK F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
APENOPEN_01203 2.5e-32 yvlD S Mycobacterial 4 TMS phage holin, superfamily IV
APENOPEN_01204 1.8e-19 KT PspC domain protein
APENOPEN_01205 5.1e-161 prfB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APENOPEN_01206 0.0 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
APENOPEN_01207 4.4e-84 hpf J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
APENOPEN_01208 3.3e-49 comFC S Competence protein
APENOPEN_01209 6.7e-142 comFA L Helicase C-terminal domain protein
APENOPEN_01210 5.2e-71 yvyE 3.4.13.9 S YigZ family
APENOPEN_01211 3.5e-162 EGP Major facilitator Superfamily
APENOPEN_01212 2.3e-22 rmaI K helix_turn_helix multiple antibiotic resistance protein
APENOPEN_01213 2e-08
APENOPEN_01214 2.3e-137 ydaO E amino acid
APENOPEN_01215 2.5e-256 gnd 1.1.1.343, 1.1.1.44 H Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
APENOPEN_01216 5.2e-84 3.2.2.20 K Acetyltransferase (GNAT) domain
APENOPEN_01217 8.9e-68 uspA T universal stress protein
APENOPEN_01218 5e-65 K AsnC family
APENOPEN_01219 1.5e-218 pepF E oligoendopeptidase F
APENOPEN_01220 8.1e-190 gltP U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
APENOPEN_01221 1.1e-13 mtlD 1.1.1.17, 1.1.1.57 G Mannitol dehydrogenase C-terminal domain
APENOPEN_01222 1.5e-154 C Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APENOPEN_01223 2.4e-111 S module of peptide synthetase
APENOPEN_01224 8.9e-257 zwf 1.1.1.363, 1.1.1.49 G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
APENOPEN_01225 1.4e-127 yeaN P Transporter, major facilitator family protein
APENOPEN_01226 3.5e-52 S 3-demethylubiquinone-9 3-methyltransferase
APENOPEN_01227 2.7e-123 1.1.1.346 C Aldo keto reductase
APENOPEN_01228 3.8e-229 S amidohydrolase
APENOPEN_01229 1e-182 adhP 1.1.1.1 C alcohol dehydrogenase
APENOPEN_01230 1.4e-59 ctsR K Belongs to the CtsR family
APENOPEN_01231 0.0 clpC O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
APENOPEN_01232 3.1e-128 ubiB S ABC1 family
APENOPEN_01233 8.4e-40
APENOPEN_01234 7.5e-07 fhaB M Rib/alpha-like repeat
APENOPEN_01235 8.5e-08 S Bacteriophage abortive infection AbiH
APENOPEN_01236 6.3e-46 copY K Copper transport repressor CopY TcrY
APENOPEN_01237 1.2e-09 3.1.3.48 D FIVAR domain
APENOPEN_01238 1.3e-185 yhdP S Transporter associated domain
APENOPEN_01239 6.6e-31
APENOPEN_01240 5.1e-38 folB 1.13.11.81, 2.5.1.15, 2.7.6.3, 4.1.2.25, 5.1.99.8 H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
APENOPEN_01241 3.3e-43 folK 1.13.11.81, 2.5.1.15, 2.7.6.3, 3.5.4.16, 4.1.2.25, 5.1.99.8 H 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)
APENOPEN_01242 4.9e-78 folE 2.7.6.3, 3.5.4.16 F GTP cyclohydrolase 1
APENOPEN_01243 2.9e-110 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
APENOPEN_01244 1.7e-49 xtp 2.5.1.15, 3.6.1.66 F Ham1 family
APENOPEN_01245 4.2e-129 folP 2.5.1.15 H dihydropteroate synthase
APENOPEN_01246 4.1e-08
APENOPEN_01247 1.7e-25
APENOPEN_01249 1.7e-69 htpX O Peptidase family M48
APENOPEN_01250 8.8e-50 S CAAX protease self-immunity
APENOPEN_01251 2e-122 gtf2 M A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1
APENOPEN_01252 3.4e-166 gtf1 2.4.1.52 GT4 M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
APENOPEN_01253 3.7e-120 rbsK 2.7.1.15 H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APENOPEN_01254 7e-120 rbsR K Periplasmic binding proteins and sugar binding domain of LacI family
APENOPEN_01255 7.3e-72
APENOPEN_01256 1.3e-178 mdh 1.1.1.350 C Belongs to the LDH2 MDH2 oxidoreductase family
APENOPEN_01257 1.3e-230 FbpA K Fibronectin-binding protein
APENOPEN_01258 1.1e-134 degV S EDD domain protein, DegV family
APENOPEN_01259 1.7e-15
APENOPEN_01260 1.5e-74 puuD S peptidase C26
APENOPEN_01261 4.7e-167 steT_1 E amino acid
APENOPEN_01262 2.1e-53 dnaX 2.4.99.16, 2.7.7.7 GH13 M domain protein
APENOPEN_01263 3.8e-53 phoU P Plays a role in the regulation of phosphate uptake
APENOPEN_01264 7.6e-95 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
APENOPEN_01265 2.1e-95 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
APENOPEN_01266 3.6e-104 pstA P Phosphate transport system permease protein PstA
APENOPEN_01267 2e-105 pstC P probably responsible for the translocation of the substrate across the membrane
APENOPEN_01268 8.7e-69 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APENOPEN_01269 7.3e-62 G phosphoglycerate mutase
APENOPEN_01270 3.5e-64 dedA S SNARE associated Golgi protein
APENOPEN_01271 0.0 helD 3.6.4.12 L DNA helicase
APENOPEN_01273 8e-30 XK27_00515 D Glucan-binding protein C
APENOPEN_01274 2e-290 pepX 3.4.14.11 E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline
APENOPEN_01275 9.7e-161 3.4.11.5 E Releases the N-terminal proline from various substrates
APENOPEN_01276 3.5e-27 ydeP K Transcriptional regulators
APENOPEN_01277 4.1e-66 1.5.1.40 S NADP oxidoreductase coenzyme F420-dependent
APENOPEN_01278 2.5e-70 gph 3.1.3.18 S HAD hydrolase, family IA, variant
APENOPEN_01279 3e-161 malZ 3.2.1.20 GH31 G Belongs to the glycosyl hydrolase 31 family
APENOPEN_01280 8.6e-202 2.4.1.52 GT4 M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
APENOPEN_01281 2.9e-130 2.4.1.52 GT4 M Glycosyl transferases group 1
APENOPEN_01282 1.9e-72 S Calcineurin-like phosphoesterase
APENOPEN_01283 5.8e-248 carB 6.3.5.5 F Carbamoyl-phosphate synthase
APENOPEN_01284 5.1e-177 carA 6.3.5.5 F Carbamoyl-phosphate synthetase glutamine chain
APENOPEN_01285 3.3e-60 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
APENOPEN_01286 4.2e-126 DegV S EDD domain protein, DegV family
APENOPEN_01287 7.9e-85 hlyIII S protein, hemolysin III
APENOPEN_01288 3.8e-42 folA 1.5.1.3 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
APENOPEN_01289 1.2e-109 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
APENOPEN_01290 1.4e-09 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
APENOPEN_01291 5e-268 yfmR S ABC transporter, ATP-binding protein
APENOPEN_01292 2.3e-149 cca 2.7.7.19, 2.7.7.72 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
APENOPEN_01293 7.8e-85 xerD L Phage integrase, N-terminal SAM-like domain
APENOPEN_01294 6.2e-147 S Tetratricopeptide repeat protein
APENOPEN_01295 5.3e-32 rpsT J Binds directly to 16S ribosomal RNA
APENOPEN_01296 1.3e-126 holA 2.7.7.7 L DNA polymerase III delta subunit
APENOPEN_01297 1.1e-178 comEC S Competence protein ComEC
APENOPEN_01298 3.6e-77 comEB 3.5.4.12 F ComE operon protein 2
APENOPEN_01299 6.5e-47 comEA L Competence protein ComEA
APENOPEN_01300 4.1e-155 ylbL T Belongs to the peptidase S16 family
APENOPEN_01301 1.5e-73 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
APENOPEN_01302 4.4e-12 yrzB S Belongs to the UPF0473 family
APENOPEN_01303 8.4e-48 cvpA S Colicin V production protein
APENOPEN_01304 0.0 mutS2 L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
APENOPEN_01305 3.7e-43 trxA O Belongs to the thioredoxin family
APENOPEN_01306 3.8e-53 yslB S Protein of unknown function (DUF2507)
APENOPEN_01307 7.6e-85 murI 3.6.1.66, 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
APENOPEN_01308 8.4e-81 rdgB 3.6.1.66, 5.1.1.3 F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APENOPEN_01309 6.7e-16
APENOPEN_01310 5.1e-87 rssA S Phospholipase, patatin family
APENOPEN_01311 3.3e-66 phoU P Plays a role in the regulation of phosphate uptake
APENOPEN_01312 8.9e-56 K Transcriptional regulatory protein, C-terminal domain protein
APENOPEN_01313 7.9e-82 S Sucrose-6F-phosphate phosphohydrolase
APENOPEN_01314 7.9e-188 rarA L recombination factor protein RarA
APENOPEN_01315 1.9e-101 IQ Oxidoreductase, short chain dehydrogenase reductase family protein
APENOPEN_01316 2.4e-171 lytS 2.7.13.3 T LytS YhcK-type transmembrane receptor domain protein
APENOPEN_01317 4.1e-91 tcyA ET Belongs to the bacterial solute-binding protein 3 family
APENOPEN_01318 4.9e-94 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
APENOPEN_01319 4e-90 tcyB E ABC transporter
APENOPEN_01320 9.6e-148 rihA F Inosine-uridine preferring nucleoside hydrolase
APENOPEN_01321 1.5e-107 hisC 2.6.1.9 E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APENOPEN_01322 1.7e-35 hisE 3.5.4.19, 3.6.1.31, 5.3.1.16 E phosphoribosyl-ATP diphosphatase activity
APENOPEN_01323 2e-42 hisI 3.5.4.19, 3.5.4.25, 3.6.1.31, 5.3.1.16 E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
APENOPEN_01324 2.8e-105 hisF 3.5.4.19, 3.6.1.31 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
APENOPEN_01325 1.2e-73 hisA 5.3.1.16 E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
APENOPEN_01326 2.5e-41 hisH E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
APENOPEN_01327 1.2e-14 hisH E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
APENOPEN_01328 2.7e-87 hisB 1.1.1.23, 2.6.1.9, 3.1.3.15, 4.2.1.19 E imidazoleglycerol-phosphate dehydratase
APENOPEN_01329 1.2e-172 hisD 1.1.1.23, 1.1.1.308 E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APENOPEN_01330 9.7e-70 hisG 2.4.2.17 E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
APENOPEN_01331 1.7e-85 hisZ 2.4.2.17, 6.1.1.21 E Histidyl-tRNA synthetase
APENOPEN_01332 2.1e-88 hisK 3.1.3.15 E Histidinol phosphate phosphatase, HisJ
APENOPEN_01333 2.6e-76 yeaN P Major Facilitator Superfamily
APENOPEN_01334 1.5e-51
APENOPEN_01335 2.4e-76 apt 2.4.2.22, 2.4.2.7 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APENOPEN_01336 1.1e-237 recJ L Single-stranded-DNA-specific exonuclease RecJ
APENOPEN_01337 5.4e-118 XK27_05435 1.1.1.100 S Belongs to the short-chain dehydrogenases reductases (SDR) family
APENOPEN_01338 1.2e-142 rnz 3.1.26.11 J Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
APENOPEN_01339 6.1e-209 obg S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
APENOPEN_01340 6.5e-302 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
APENOPEN_01342 1.7e-78 engB D Necessary for normal cell division and for the maintenance of normal septation
APENOPEN_01343 5.8e-217 clpX O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
APENOPEN_01344 2.4e-173 tig D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
APENOPEN_01345 4.2e-181 ade 3.5.4.2 F Adenine deaminase C-terminal domain
APENOPEN_01346 7.5e-186 pbuG S permease
APENOPEN_01348 1.1e-51 3.1.3.102, 3.1.3.104 S hydrolase
APENOPEN_01349 6.8e-134 aspA 4.2.1.2, 4.3.1.1 E Fumarase C C-terminus
APENOPEN_01350 3.1e-63 S Alpha beta hydrolase
APENOPEN_01352 1.4e-70 ddaH 3.5.3.18 E PFAM amidinotransferase
APENOPEN_01353 4.6e-125 lysN K Alanine-glyoxylate amino-transferase
APENOPEN_01354 2.3e-41 S PFAM Archaeal ATPase
APENOPEN_01355 1.2e-38 paiA 2.3.1.57 K Acetyltransferase (GNAT) domain
APENOPEN_01356 2.2e-37 clcA_2 P Chloride transporter, ClC family
APENOPEN_01357 3.1e-137 L hmm pf00665
APENOPEN_01358 2e-45 L Helix-turn-helix domain
APENOPEN_01359 3.3e-78 tenA 3.5.99.2 K Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
APENOPEN_01360 0.0 copA 3.6.3.54 P P-type ATPase
APENOPEN_01361 1.5e-43 silP 1.9.3.1, 3.6.3.54 S Cupredoxin-like domain
APENOPEN_01362 4.4e-59 silP 1.9.3.1, 3.6.3.54 S Cupredoxin-like domain
APENOPEN_01363 8.3e-60 2.7.7.7, 3.4.21.110 D Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APENOPEN_01364 8.6e-86 suhB 3.1.3.25 G Belongs to the inositol monophosphatase superfamily
APENOPEN_01365 1.4e-25 yktA S Belongs to the UPF0223 family
APENOPEN_01366 2.3e-88 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
APENOPEN_01367 9e-30
APENOPEN_01368 2.4e-22 ykzG S Belongs to the UPF0356 family
APENOPEN_01369 8.8e-96 ytlR 2.7.1.91 I Diacylglycerol kinase catalytic
APENOPEN_01370 1.4e-14
APENOPEN_01371 9.6e-52 mltD CBM50 M NlpC P60 family protein
APENOPEN_01372 2.6e-44 spx4 1.20.4.1 P ArsC family
APENOPEN_01373 4.1e-120 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APENOPEN_01374 3.8e-175 recD2 3.1.11.5 L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
APENOPEN_01375 2.3e-07 recD2 3.1.11.5 L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
APENOPEN_01376 1e-93 S Repeat protein
APENOPEN_01377 9.3e-89 pgm6 5.4.2.11, 5.4.2.12 G phosphoglycerate mutase
APENOPEN_01378 8.5e-207 mnmA 2.8.1.13 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
APENOPEN_01379 2e-34 XK27_04120 S Putative amino acid metabolism
APENOPEN_01380 1.1e-95 mtnN 3.2.2.9 E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
APENOPEN_01382 2.9e-57 nudF 3.6.1.13 L ADP-ribose pyrophosphatase
APENOPEN_01383 8.5e-19 cspA K Cold shock protein
APENOPEN_01384 0.0 ileS 6.1.1.5 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
APENOPEN_01385 9.5e-55 divIVA D DivIVA domain protein
APENOPEN_01386 7.2e-96 ylmH S S4 domain protein
APENOPEN_01387 1.6e-23 yggT S YGGT family
APENOPEN_01388 3.6e-28 sepF D Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
APENOPEN_01389 6.5e-166 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
APENOPEN_01390 2.3e-174 ftsA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
APENOPEN_01391 1e-22 divIB D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
APENOPEN_01392 6.4e-242 yhcA V ABC transporter, ATP-binding protein
APENOPEN_01393 1.6e-42 argR K Regulates arginine biosynthesis genes
APENOPEN_01394 1.5e-33 czrA K Transcriptional regulator, ArsR family
APENOPEN_01395 1.5e-137 acm2 3.2.1.17 NU Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
APENOPEN_01396 6.9e-162 uhpT EGP Major facilitator Superfamily
APENOPEN_01397 3.2e-259 gtfA 2.4.1.7 GH13 G Sucrose glucosyltransferase
APENOPEN_01398 7.3e-127 scrR K Transcriptional regulator, LacI family
APENOPEN_01399 2.9e-14
APENOPEN_01400 8.1e-43 S Short repeat of unknown function (DUF308)
APENOPEN_01401 1.5e-64
APENOPEN_01402 1.9e-82 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APENOPEN_01403 1.7e-82 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX
APENOPEN_01404 2.1e-22
APENOPEN_01405 1.5e-34
APENOPEN_01406 5.8e-40 yeaO S Protein of unknown function, DUF488
APENOPEN_01407 1.1e-75 mpg 3.2.2.21 L Belongs to the DNA glycosylase MPG family
APENOPEN_01408 2.5e-113 3.1.3.1 S associated with various cellular activities
APENOPEN_01409 1.1e-90 S Putative metallopeptidase domain
APENOPEN_01410 3.1e-15
APENOPEN_01411 1.6e-266 pepO 3.4.24.71 O Peptidase family M13
APENOPEN_01412 1.2e-67 ymdB S Macro domain protein
APENOPEN_01413 6.8e-47 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
APENOPEN_01414 1.9e-54
APENOPEN_01415 5.2e-32
APENOPEN_01416 3.6e-32
APENOPEN_01417 1.6e-55 ptp3 3.1.3.48 T Tyrosine phosphatase family
APENOPEN_01418 8.6e-75 celE 3.2.1.4 GH5,GH9 E GDSL-like Lipase/Acylhydrolase family
APENOPEN_01419 3e-112 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
APENOPEN_01420 1.4e-63 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APENOPEN_01423 4e-15 S Replication initiator protein A (RepA) N-terminus
APENOPEN_01424 5.7e-13
APENOPEN_01425 6.3e-10 K DNA-templated transcription, initiation
APENOPEN_01428 7.2e-10 S Protein of unknown function (DUF2922)
APENOPEN_01429 2.6e-27
APENOPEN_01430 2.4e-234 L Helicase C-terminal domain protein
APENOPEN_01431 4.7e-62 ponA V Beta-lactamase enzyme family
APENOPEN_01432 5.6e-100 dacA 3.4.16.4 M Belongs to the peptidase S11 family
APENOPEN_01433 2.1e-18 yneR S Belongs to the HesB IscA family
APENOPEN_01435 0.0 pepN 3.4.11.2 E aminopeptidase
APENOPEN_01436 1.7e-212 yifK E Amino acid permease
APENOPEN_01437 4e-90 yicL EG EamA-like transporter family
APENOPEN_01438 6.1e-38 Q Methyltransferase domain
APENOPEN_01439 2.8e-126 clcA_2 P Chloride transporter, ClC family
APENOPEN_01440 5.2e-88 S Belongs to the UPF0246 family
APENOPEN_01441 1.7e-103 pheA 4.2.1.51, 5.4.99.5 E Psort location Cytoplasmic, score 9.98
APENOPEN_01442 7.9e-94 bacI V MacB-like periplasmic core domain
APENOPEN_01443 7e-87 V ABC transporter
APENOPEN_01444 6e-45 bacG M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APENOPEN_01445 1.1e-44 thiW S Thiamine-precursor transporter protein (ThiW)
APENOPEN_01446 1.3e-21 S Cytochrome b5-like Heme/Steroid binding domain
APENOPEN_01447 1e-66 XK27_08850 S Aminoacyl-tRNA editing domain
APENOPEN_01448 2.1e-136 spoU 2.1.1.185 J Methyltransferase
APENOPEN_01449 5.6e-278 guaA 2.3.1.128, 6.3.5.2 F Catalyzes the synthesis of GMP from XMP
APENOPEN_01451 3.4e-157 mdh 1.1.1.350 C Belongs to the LDH2 MDH2 oxidoreductase family
APENOPEN_01452 4.5e-67 E GDSL-like Lipase/Acylhydrolase family
APENOPEN_01453 1.6e-148 lplA 6.3.1.20 H Lipoate-protein ligase
APENOPEN_01454 8.5e-143 lpdA 1.8.1.4 C Dehydrogenase
APENOPEN_01455 2.1e-75 trmK 2.1.1.217 S SAM-dependent methyltransferase
APENOPEN_01456 5.7e-173 asd 1.2.1.11 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APENOPEN_01457 3.9e-154 patA 2.6.1.1 E Aminotransferase
APENOPEN_01458 5.3e-107 dapB 1.17.1.8 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
APENOPEN_01459 9.3e-135 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APENOPEN_01460 1.9e-185 hipO 3.5.1.47 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
APENOPEN_01461 1.6e-54 dapD 2.3.1.117, 2.3.1.89 E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
APENOPEN_01462 2e-204 lysA 4.1.1.19, 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
APENOPEN_01463 3.4e-194 lysC 2.7.2.4 E Belongs to the aspartokinase family
APENOPEN_01464 2.5e-133 dapF 5.1.1.7 E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
APENOPEN_01465 7.8e-191 U Belongs to the purine-cytosine permease (2.A.39) family
APENOPEN_01466 2.5e-199 codA 3.5.4.1 F cytosine deaminase
APENOPEN_01467 1.4e-193 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
APENOPEN_01468 6.7e-175 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
APENOPEN_01469 3.6e-296 glyS 6.1.1.14 J Glycyl-tRNA synthetase beta subunit
APENOPEN_01470 2.2e-171 glyQ 6.1.1.14 J glycyl-tRNA synthetase alpha subunit
APENOPEN_01471 4.7e-87 recO L Involved in DNA repair and RecF pathway recombination
APENOPEN_01472 6.9e-143 era S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
APENOPEN_01473 3.3e-36 dgkA 2.7.1.107, 2.7.1.66 M Diacylglycerol kinase
APENOPEN_01474 1.3e-60 ybeY 2.6.99.2, 3.5.4.5 S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
APENOPEN_01475 2.6e-148 phoH T phosphate starvation-inducible protein PhoH
APENOPEN_01476 9.2e-48 yqeY S YqeY-like protein
APENOPEN_01477 3.3e-149 pdhC 2.3.1.12 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
APENOPEN_01478 5.3e-157 pdhB 1.2.4.1 C Transketolase, C-terminal domain protein
APENOPEN_01479 4e-153 pdhA 1.2.4.1, 1.2.4.4 C Dehydrogenase E1 component
APENOPEN_01480 2.4e-120 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
APENOPEN_01481 1.8e-104 lrgB M LrgB-like family
APENOPEN_01482 6.8e-16 lrgA S LrgA family
APENOPEN_01484 1.8e-130 livJ E Receptor family ligand binding region
APENOPEN_01485 2e-110 livH U Branched-chain amino acid transport system / permease component
APENOPEN_01486 1.6e-84 livM E Branched-chain amino acid transport system / permease component
APENOPEN_01487 1.1e-83 livG E Branched-chain amino acid ATP-binding cassette transporter
APENOPEN_01488 7.2e-87 livF E ABC transporter
APENOPEN_01489 3e-269 fhs 6.3.4.3 F Belongs to the formate--tetrahydrofolate ligase family
APENOPEN_01490 7.4e-67 purE 5.4.99.18 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
APENOPEN_01491 5.9e-163 purK 6.3.4.18 F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
APENOPEN_01492 4.5e-228 purB 4.3.2.2 F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APENOPEN_01493 1.1e-111 purC 4.1.1.21, 4.3.2.2, 6.3.2.6 F Belongs to the SAICAR synthetase family
APENOPEN_01494 1.4e-24 purS 6.3.2.6, 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APENOPEN_01495 3.4e-110 purQ 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APENOPEN_01496 0.0 purL 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APENOPEN_01497 1.7e-236 purF 2.4.2.14 F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
APENOPEN_01498 6.3e-140 purM 6.3.3.1, 6.3.4.13 F Phosphoribosylformylglycinamidine cyclo-ligase
APENOPEN_01499 3.8e-81 purN 2.1.2.2 F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
APENOPEN_01500 1.2e-259 purH 2.1.2.3, 3.5.4.10 F Bifunctional purine biosynthesis protein PurH
APENOPEN_01501 2.3e-168 purD 6.3.4.13 F Belongs to the GARS family
APENOPEN_01502 6.1e-136 argE 3.5.1.18 E succinyl-diaminopimelate desuccinylase
APENOPEN_01503 7.3e-10 psiE S Phosphate-starvation-inducible E
APENOPEN_01504 3.8e-125 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
APENOPEN_01505 7.2e-77
APENOPEN_01506 2.3e-38 K transcriptional regulator PadR family
APENOPEN_01507 5.7e-16 XK27_06920 S Protein of unknown function (DUF1700)
APENOPEN_01508 2.9e-14 S Putative adhesin
APENOPEN_01509 3.3e-12 pspC KT Transcriptional regulator
APENOPEN_01510 2e-229 yhdG E C-terminus of AA_permease
APENOPEN_01511 7.5e-47 uspA T Universal stress protein family
APENOPEN_01512 8.5e-109 patA 2.6.1.1 E Aminotransferase class I and II
APENOPEN_01513 4.9e-218 yjeM E Amino Acid
APENOPEN_01514 2.6e-92 dacA 3.4.16.4 M Belongs to the peptidase S11 family
APENOPEN_01516 3.7e-74 yciB M ErfK YbiS YcfS YnhG
APENOPEN_01517 5.8e-72 S NAD(P)H-binding
APENOPEN_01518 7.1e-48 K Transcriptional regulator
APENOPEN_01519 3.2e-46
APENOPEN_01520 6.2e-254 XK27_00340 3.1.3.5 F Belongs to the 5'-nucleotidase family
APENOPEN_01521 9.7e-87 ybgJ 3.5.1.54 E Allophanate hydrolase subunit 1
APENOPEN_01522 1.3e-105 kipA 6.3.4.6 E Allophanate hydrolase subunit 2
APENOPEN_01523 3e-103 adk 2.7.4.3 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
APENOPEN_01524 2.9e-219 secY U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
APENOPEN_01525 5.6e-58 rplO J Binds to the 23S rRNA
APENOPEN_01526 2.7e-22 rpmD J Ribosomal protein L30
APENOPEN_01527 2e-78 rpsE J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
APENOPEN_01528 2.4e-54 rplR J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
APENOPEN_01529 7.9e-78 rplF J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
APENOPEN_01530 5.7e-65 rpsH J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
APENOPEN_01531 4.1e-26 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APENOPEN_01532 4.2e-87 rplE J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APENOPEN_01533 4.3e-23 D nuclear chromosome segregation
APENOPEN_01538 1.2e-190 cysS 6.1.1.16, 6.3.1.13 J Belongs to the class-I aminoacyl-tRNA synthetase family
APENOPEN_01539 1.4e-61 mrnC J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
APENOPEN_01540 8e-121 rlmB 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APENOPEN_01541 2.5e-194 npp S type I phosphodiesterase nucleotide pyrophosphatase
APENOPEN_01542 6.9e-170 yxiO S Vacuole effluxer Atg22 like
APENOPEN_01543 2.8e-68 U type IV secretory pathway VirB4
APENOPEN_01545 5.6e-31 M Peptidase family M23
APENOPEN_01549 6.5e-10 ydiL S protease
APENOPEN_01551 5e-103 metQ1 P Belongs to the nlpA lipoprotein family
APENOPEN_01552 5.6e-144 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APENOPEN_01553 3.8e-80 metI P ABC transporter permease
APENOPEN_01554 1.4e-132 argE 3.5.1.18 E succinyl-diaminopimelate desuccinylase
APENOPEN_01567 4.4e-57 lysA 4.1.1.20 E diaminopimelate decarboxylase
APENOPEN_01568 8.2e-228 rumA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APENOPEN_01569 1.2e-100 nqr 1.5.1.36 S reductase
APENOPEN_01570 6.1e-198 XK27_09615 S reductase
APENOPEN_01571 2.8e-173 apbE 2.7.1.180 H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
APENOPEN_01573 1.7e-209 nqr 1.3.5.4, 1.5.1.36 C FMN_bind
APENOPEN_01576 7.7e-15
APENOPEN_01577 3.1e-33 I PFAM Prenyltransferase squalene oxidase
APENOPEN_01579 1.8e-34 yqkB S Belongs to the HesB IscA family
APENOPEN_01580 4.4e-90 K Arabinose-binding domain of AraC transcription regulator, N-term
APENOPEN_01581 1.9e-121 fadB4 1.1.1.157 I 3-hydroxyacyl-CoA dehydrogenase
APENOPEN_01582 8.1e-22 T pyridoxamine 5'-phosphate
APENOPEN_01583 7.5e-96 lexA 3.4.21.88 K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APENOPEN_01584 1.3e-30 ynzC S UPF0291 protein
APENOPEN_01585 7.2e-20 yneF S Uncharacterised protein family (UPF0154)
APENOPEN_01586 9e-89 plsC 2.3.1.51 I Acyltransferase
APENOPEN_01587 1.3e-97 yabB 2.1.1.223 L Methyltransferase small domain
APENOPEN_01588 1.9e-27 yazA L GIY-YIG catalytic domain protein
APENOPEN_01589 8.6e-64 lysS 6.1.1.6 J Belongs to the class-II aminoacyl-tRNA synthetase family
APENOPEN_01590 3.1e-163 dus J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APENOPEN_01591 5e-85 lmrP E Major Facilitator Superfamily
APENOPEN_01592 3.7e-120 hslO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
APENOPEN_01593 9.6e-297 ftsH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APENOPEN_01594 7.7e-73 hpt 2.4.2.8 F Belongs to the purine pyrimidine phosphoribosyltransferase family
APENOPEN_01595 3.5e-100 tilS 2.4.2.8, 6.3.4.19 J Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
APENOPEN_01596 2e-41 yabR J RNA binding
APENOPEN_01597 2.6e-16 divIC D Septum formation initiator
APENOPEN_01598 2.3e-28 yabO J S4 domain protein
APENOPEN_01599 0.0 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APENOPEN_01600 3.3e-87 pth 3.1.1.29 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
APENOPEN_01601 1.2e-85 S (CBS) domain
APENOPEN_01602 9.3e-35 ndoA L Toxic component of a toxin-antitoxin (TA) module
APENOPEN_01603 1.3e-138 alr 5.1.1.1 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APENOPEN_01604 3.6e-37 acpS 2.7.6.3, 2.7.8.7, 5.1.1.1 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
APENOPEN_01605 1.9e-222 cshA 3.6.4.13 F DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
APENOPEN_01606 1.1e-184 murF 6.3.2.10 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
APENOPEN_01607 2.6e-110 htpX O Belongs to the peptidase M48B family
APENOPEN_01608 1.1e-58 lemA S LemA family
APENOPEN_01609 1.2e-58 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
APENOPEN_01610 3.6e-83 srtA 3.4.22.70 M sortase family
APENOPEN_01611 8.7e-40 rpmE2 J Ribosomal protein L31
APENOPEN_01612 1.2e-209 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APENOPEN_01613 1.6e-275 pyrG 6.3.4.2 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
APENOPEN_01614 9e-49 rpoE K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
APENOPEN_01615 7.3e-34 ywiB S Domain of unknown function (DUF1934)
APENOPEN_01616 4.4e-218 ywfO S HD domain protein
APENOPEN_01617 4.4e-96 yxeH S hydrolase
APENOPEN_01618 2.5e-195 pncB 6.3.4.21 F Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
APENOPEN_01619 7.1e-74 pncA Q Isochorismatase family
APENOPEN_01620 4.8e-89 3.6.1.13, 3.6.1.55 F NUDIX domain
APENOPEN_01621 7.8e-20
APENOPEN_01622 4.1e-157 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APENOPEN_01623 1.4e-187 glmU 2.3.1.157, 2.7.7.23 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
APENOPEN_01624 1.5e-131 purR 2.4.2.22, 2.4.2.7 F pur operon repressor
APENOPEN_01625 9.2e-91 znuB U ABC 3 transport family
APENOPEN_01626 8.3e-77 fhuC P ABC transporter
APENOPEN_01627 7.5e-97 znuA P Belongs to the bacterial solute-binding protein 9 family
APENOPEN_01628 4e-230 E Arginine ornithine antiporter
APENOPEN_01629 3.5e-206 arcA 3.5.3.6 E Arginine
APENOPEN_01630 5.7e-123 ispE 2.1.1.182, 2.7.1.148 F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
APENOPEN_01631 9.5e-23 veg S Biofilm formation stimulator VEG
APENOPEN_01632 1.1e-124 ksgA 2.1.1.182 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
APENOPEN_01633 1.2e-63 rnmV 3.1.26.8 J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
APENOPEN_01634 7.8e-98 tatD L hydrolase, TatD family
APENOPEN_01635 0.0 metG 6.1.1.10 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APENOPEN_01636 8.9e-108 yunF F Protein of unknown function DUF72
APENOPEN_01637 5e-104 cobB K SIR2 family
APENOPEN_01638 2.6e-124
APENOPEN_01639 2.4e-141 mvaA 1.1.1.34, 1.1.1.88, 2.3.1.9 C Belongs to the HMG-CoA reductase family
APENOPEN_01640 9.2e-138 ppx 3.6.1.11, 3.6.1.40 FP exopolyphosphatase
APENOPEN_01641 6.2e-289 helD 3.6.4.12 L DNA helicase
APENOPEN_01642 3.2e-156 napA P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
APENOPEN_01644 3.2e-91 yxiO S Vacuole effluxer Atg22 like
APENOPEN_01645 1.1e-37 yxiO S Vacuole effluxer Atg22 like
APENOPEN_01646 1.5e-54 O ADP-ribosylglycohydrolase
APENOPEN_01647 5.9e-98 S membrane transporter protein
APENOPEN_01648 1.1e-68 pgpA 3.1.3.27 I Phosphatidylglycerophosphatase A
APENOPEN_01650 1.2e-42 phaG GT1 I carboxylic ester hydrolase activity
APENOPEN_01651 1.8e-125 cbh 3.5.1.24 M Linear amide C-N hydrolases, choloylglycine hydrolase family
APENOPEN_01652 9.4e-128 rpsB J Belongs to the universal ribosomal protein uS2 family
APENOPEN_01653 6.5e-122 tsf J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
APENOPEN_01654 1.1e-111 pyrH 2.7.4.22 F Catalyzes the reversible phosphorylation of UMP to UDP
APENOPEN_01655 5.2e-80 frr J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
APENOPEN_01656 1.1e-109 uppS 2.5.1.31 H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APENOPEN_01657 5.3e-107 cdsA 2.7.7.41 I Belongs to the CDS family
APENOPEN_01658 4.6e-185 rseP 3.4.21.107, 3.4.21.116 M zinc metalloprotease
APENOPEN_01659 4.5e-284 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
APENOPEN_01660 0.0 polC 2.7.7.7 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APENOPEN_01661 9.6e-65 rimP J Required for maturation of 30S ribosomal subunits
APENOPEN_01662 9.1e-130 nusA K Participates in both transcription termination and antitermination
APENOPEN_01663 1.8e-33 ylxR K Protein of unknown function (DUF448)
APENOPEN_01664 1.5e-23 ylxQ J ribosomal protein
APENOPEN_01665 4.3e-308 infB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
APENOPEN_01666 1.2e-50 rbfA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
APENOPEN_01667 3e-114 truB 5.4.99.25 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
APENOPEN_01668 1.5e-111 ribF 2.7.1.26, 2.7.7.2 H Belongs to the ribF family
APENOPEN_01669 1.2e-107 glxR 1.1.1.31, 1.1.1.60 I Dehydrogenase
APENOPEN_01670 2e-150 2.1.1.14 E methionine synthase, vitamin-B12 independent
APENOPEN_01671 2.5e-14
APENOPEN_01673 4.1e-49 thiE 2.5.1.3, 2.7.6.2, 5.4.2.6 S Haloacid dehalogenase-like hydrolase
APENOPEN_01674 2.6e-54 hmpT S ECF-type riboflavin transporter, S component
APENOPEN_01675 9.2e-61 pdxK 2.7.1.35 H Phosphomethylpyrimidine kinase
APENOPEN_01677 7.9e-191 cshB 3.6.4.13 JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
APENOPEN_01678 6.3e-147 nrnA 3.1.13.3, 3.1.3.7 S DHHA1 domain protein
APENOPEN_01679 4e-14 yajC U Preprotein translocase
APENOPEN_01680 3.6e-61 tgt 2.4.2.29 F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
APENOPEN_01681 8.8e-147 ruvB 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
APENOPEN_01682 4.1e-67 ruvA 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
APENOPEN_01683 1.2e-235 mutL L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
APENOPEN_01684 0.0 mutS L that it carries out the mismatch recognition step. This protein has a weak ATPase activity
APENOPEN_01685 1.2e-182 rny S Endoribonuclease that initiates mRNA decay
APENOPEN_01686 1.1e-171 recA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
APENOPEN_01687 3.6e-129 cinA 3.5.1.42 S Belongs to the CinA family
APENOPEN_01688 1.9e-93 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
APENOPEN_01689 1.3e-60 ymfM S Helix-turn-helix domain
APENOPEN_01690 5.6e-162 ymfH S Peptidase M16
APENOPEN_01691 6.1e-113 ymfF S Peptidase M16 inactive domain protein
APENOPEN_01692 9.8e-123 aatB ET ABC transporter substrate-binding protein
APENOPEN_01693 1.1e-91 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
APENOPEN_01694 1.1e-94 glnP P ABC transporter permease
APENOPEN_01695 2.4e-17 mreD M rod shape-determining protein MreD
APENOPEN_01696 6.6e-115 scrR3 K Transcriptional regulator, LacI family
APENOPEN_01697 1.4e-119 gshF 6.3.2.2 H Belongs to the glutamate--cysteine ligase type 1 family
APENOPEN_01698 6e-07 aroK 1.1.1.25, 2.7.1.71, 4.2.1.10, 4.2.3.4 F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APENOPEN_01699 7.9e-116 1.1.1.28 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APENOPEN_01700 0.0 mgtA 3.6.3.2 P Cation transporter/ATPase, N-terminus
APENOPEN_01701 1.9e-123 S Predicted membrane protein (DUF2207)
APENOPEN_01702 2.3e-121 S Amidohydrolase
APENOPEN_01703 6.3e-99 MA20_03535 1.1.1.399, 1.1.1.95 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APENOPEN_01704 2.3e-93 azlC E AzlC protein
APENOPEN_01705 7.3e-38 azlD S branched-chain amino acid
APENOPEN_01706 2e-68 ydeN S Serine hydrolase
APENOPEN_01707 1.3e-197 cfa 2.1.1.317, 2.1.1.79 M cyclopropane-fatty-acyl-phospholipid synthase
APENOPEN_01708 7.6e-58 perR P Belongs to the Fur family
APENOPEN_01709 5.6e-34
APENOPEN_01710 3e-194 metK 2.5.1.6 H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
APENOPEN_01711 4.5e-106 apbE 2.7.1.180 H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
APENOPEN_01712 4.9e-72 GK ROK family
APENOPEN_01713 0.0 leuS 6.1.1.4 J Belongs to the class-I aminoacyl-tRNA synthetase family
APENOPEN_01714 7.6e-26
APENOPEN_01715 1.6e-96 papP P ABC transporter, permease protein
APENOPEN_01716 2.2e-77 P ABC transporter permease
APENOPEN_01717 2.8e-102 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
APENOPEN_01718 2.7e-120 cjaA ET ABC transporter substrate-binding protein
APENOPEN_01719 2.6e-26 metC1 4.4.1.8 E cystathionine
APENOPEN_01720 3.6e-28 metB 2.5.1.48, 4.4.1.8 E Cys/Met metabolism PLP-dependent enzyme
APENOPEN_01721 1.3e-203 ytgP S Polysaccharide biosynthesis protein
APENOPEN_01723 5.1e-103 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
APENOPEN_01724 6e-202 pepV 3.5.1.18 E dipeptidase PepV
APENOPEN_01725 1.9e-57 uspA T Belongs to the universal stress protein A family
APENOPEN_01726 3e-153 S Putative peptidoglycan binding domain
APENOPEN_01727 1.5e-44 3.2.1.17 NU Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
APENOPEN_01728 5.8e-89 dck 2.7.1.74 F deoxynucleoside kinase
APENOPEN_01729 8.9e-227 pgi 5.3.1.9 G Belongs to the GPI family
APENOPEN_01730 4.7e-83 glpF U Belongs to the MIP aquaporin (TC 1.A.8) family
APENOPEN_01731 3.1e-33 ypaA S Protein of unknown function (DUF1304)
APENOPEN_01732 3.9e-48 XK27_08875 O PFAM peptidase M10A and M12B, matrixin and adamalysin
APENOPEN_01733 1.2e-97 ytbE 1.1.1.346 S Aldo keto reductase
APENOPEN_01734 4.3e-94 pgmB 2.4.1.64, 3.1.3.12, 3.2.1.28, 5.4.2.6 GH37,GH65 S beta-phosphoglucomutase
APENOPEN_01735 0.0 mapA 2.4.1.8 GH65 G hydrolase, family 65, central catalytic
APENOPEN_01736 3.9e-227 malT G Major Facilitator

eggNOG-mapper v2 (Database: eggNOG v5.0, Jul. 2018 release)