ORF_ID e_value Gene_name EC_number CAZy COGs Description
COFKGGJM_00001 8.2e-66 ssb L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
COFKGGJM_00002 3.9e-63 srlB 2.7.1.198 G PTS system glucitol/sorbitol-specific IIA component
COFKGGJM_00004 1.4e-234 S Tetratricopeptide repeat protein
COFKGGJM_00005 8.2e-224 cca 2.7.7.19, 2.7.7.72 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
COFKGGJM_00006 0.0 yfmR S ABC transporter, ATP-binding protein
COFKGGJM_00007 7.2e-191 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
COFKGGJM_00008 9.6e-91 folA 1.5.1.3 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
COFKGGJM_00009 1.9e-110 hlyIII S protein, hemolysin III
COFKGGJM_00010 4.9e-151 DegV S EDD domain protein, DegV family
COFKGGJM_00011 8.3e-168 ypmR E lipolytic protein G-D-S-L family
COFKGGJM_00012 8.2e-108 ypmS S Uncharacterized protein conserved in bacteria (DUF2140)
COFKGGJM_00013 4.4e-35 yozE S Belongs to the UPF0346 family
COFKGGJM_00014 2.5e-158 ylqF S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
COFKGGJM_00015 4.2e-141 rnhB 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
COFKGGJM_00016 7.8e-160 dprA LU DNA protecting protein DprA
COFKGGJM_00017 0.0 topA 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
COFKGGJM_00018 2e-163 lacX 5.1.3.3 G Aldose 1-epimerase
COFKGGJM_00019 1.2e-104 plsY 2.3.1.15, 3.5.1.104 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
COFKGGJM_00020 0.0 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
COFKGGJM_00021 0.0 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
COFKGGJM_00022 8.1e-79 F NUDIX domain
COFKGGJM_00023 8.6e-173 ppaC 3.6.1.1 C inorganic pyrophosphatase
COFKGGJM_00024 2.7e-67 yqkB S Belongs to the HesB IscA family
COFKGGJM_00025 1.1e-25
COFKGGJM_00027 1.6e-85 ywnH 2.3.1.183 M Acetyltransferase (GNAT) domain
COFKGGJM_00028 6.9e-60 asp S Asp23 family, cell envelope-related function
COFKGGJM_00029 6.1e-25
COFKGGJM_00030 2.6e-92
COFKGGJM_00031 6.3e-290 gntK 2.7.1.12, 2.7.1.17 G Belongs to the FGGY kinase family
COFKGGJM_00032 4.9e-182 K Transcriptional regulator, LacI family
COFKGGJM_00033 9e-232 gntT EG Gluconate
COFKGGJM_00034 1.6e-293 gntK 2.7.1.12, 2.7.1.17 G Belongs to the FGGY kinase family
COFKGGJM_00035 2.9e-96 K Acetyltransferase (GNAT) domain
COFKGGJM_00036 9.1e-12
COFKGGJM_00037 2.4e-22
COFKGGJM_00038 2.2e-44
COFKGGJM_00039 1.2e-56 yhaI S Protein of unknown function (DUF805)
COFKGGJM_00040 5.4e-176 yfjM S Protein of unknown function DUF262
COFKGGJM_00041 3e-300 2.1.1.72 V type I restriction-modification system
COFKGGJM_00042 1.1e-26 3.1.21.3 V Type I restriction modification DNA specificity domain
COFKGGJM_00043 7.2e-33 hsdS 3.1.21.3 V Type I restriction modification DNA specificity domain
COFKGGJM_00044 2.1e-177 xerC L Belongs to the 'phage' integrase family
COFKGGJM_00045 3e-46 hsdS 2.1.1.72, 3.1.21.3 V type I restriction modification DNA specificity domain
COFKGGJM_00046 0.0 hsdR 3.1.21.3 V Subunit R is required for both nuclease and ATPase activities, but not for modification
COFKGGJM_00047 5.3e-34 higA K addiction module antidote protein HigA
COFKGGJM_00048 0.0 L PLD-like domain
COFKGGJM_00050 1.5e-177 rihA 3.2.2.1 F Inosine-uridine preferring nucleoside hydrolase
COFKGGJM_00051 2.6e-181 ribD 1.1.1.193, 3.5.4.26 H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
COFKGGJM_00052 3.7e-92 ribE 2.5.1.9, 3.5.4.25, 4.1.99.12 H Riboflavin synthase
COFKGGJM_00053 3.1e-220 ribBA 3.5.4.25, 4.1.99.12 H Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate
COFKGGJM_00054 9.7e-77 ribH 2.5.1.78 H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
COFKGGJM_00055 1.2e-102 T Ion transport 2 domain protein
COFKGGJM_00056 0.0 S Bacterial membrane protein YfhO
COFKGGJM_00057 3.3e-85 L PFAM transposase IS200-family protein
COFKGGJM_00058 2.4e-52 L transposase, IS605 OrfB family
COFKGGJM_00059 4.6e-35 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
COFKGGJM_00060 0.0 rexB 3.1.21.3, 3.6.4.12 L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' - 3' nuclease activity
COFKGGJM_00061 0.0 addA 3.6.4.12 L ATP-dependent helicase nuclease subunit A
COFKGGJM_00062 4.3e-172 malR K Transcriptional regulator, LacI family
COFKGGJM_00063 5.7e-214 phbA 2.3.1.9 I Belongs to the thiolase family
COFKGGJM_00064 1.1e-256 malT G Major Facilitator
COFKGGJM_00065 0.0 mapA 2.4.1.8 GH65 G hydrolase, family 65, central catalytic
COFKGGJM_00066 5.4e-121 pgmB 2.4.1.64, 3.1.3.12, 3.2.1.28, 5.4.2.6 GH37,GH65 S beta-phosphoglucomutase
COFKGGJM_00067 1e-71
COFKGGJM_00068 3.7e-87 2.7.6.5 T Region found in RelA / SpoT proteins
COFKGGJM_00069 3.3e-118 K response regulator
COFKGGJM_00070 3.1e-226 sptS 2.7.13.3 T Histidine kinase
COFKGGJM_00071 1.4e-215 yfeO P Voltage gated chloride channel
COFKGGJM_00072 1.6e-257 gshF 6.3.2.2 H Belongs to the glutamate--cysteine ligase type 1 family
COFKGGJM_00073 6.6e-136 puuD S peptidase C26
COFKGGJM_00074 5.9e-168 yvgN C Aldo keto reductase
COFKGGJM_00075 0.0 glpQ 3.1.4.46 C Membrane domain of glycerophosphoryl diester phosphodiesterase
COFKGGJM_00076 3e-87 hmpT S ECF-type riboflavin transporter, S component
COFKGGJM_00077 1.7e-262 nox C NADH oxidase
COFKGGJM_00078 9.9e-188 guaC 1.1.1.205, 1.7.1.7 F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
COFKGGJM_00079 5.3e-253 purA 6.3.4.4 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
COFKGGJM_00080 6.9e-83
COFKGGJM_00081 1.4e-95 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
COFKGGJM_00083 1.1e-13 steT_1 E amino acid
COFKGGJM_00084 2.1e-12 K Transcriptional regulator, TetR family
COFKGGJM_00085 3.4e-74 K Transcriptional regulator, TetR family
COFKGGJM_00086 8.3e-72
COFKGGJM_00087 1.5e-267 tagE3 2.4.1.52 GT4 M Glycosyl transferases group 1
COFKGGJM_00088 1.4e-270 tagE2 2.4.1.52 GT4 M Poly(Glycerol-phosphate) alpha-glucosyltransferase
COFKGGJM_00089 1.1e-271 M protein which possibly mediates interactions of S.aureus with components of the extracellular matrix of higher eukaryotes
COFKGGJM_00090 0.0 malL 3.2.1.10 GH13 G Alpha amylase, catalytic domain protein
COFKGGJM_00091 8.3e-265 G Major Facilitator
COFKGGJM_00092 0.0 carB 6.3.5.5 F Carbamoyl-phosphate synthase
COFKGGJM_00093 4.8e-207 carA 6.3.5.5 F Carbamoyl-phosphate synthetase glutamine chain
COFKGGJM_00094 6.1e-260 G Major Facilitator
COFKGGJM_00095 1.1e-173 K Transcriptional regulator, LacI family
COFKGGJM_00096 5.9e-266 rumA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
COFKGGJM_00098 2.1e-100 nqr 1.5.1.36 S reductase
COFKGGJM_00099 5.9e-201 XK27_09615 S reductase
COFKGGJM_00100 1.7e-176 apbE 2.7.1.180 H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
COFKGGJM_00102 5.6e-84
COFKGGJM_00103 6.9e-170 L Belongs to the 'phage' integrase family
COFKGGJM_00104 6.9e-19 S Excisionase from transposon Tn916
COFKGGJM_00107 3.7e-153
COFKGGJM_00109 1.6e-76 L Resolvase, N terminal domain
COFKGGJM_00110 2.2e-10 L Resolvase, N terminal domain
COFKGGJM_00111 2.7e-11 dnaQ 2.7.7.7 L Psort location Cytoplasmic, score 8.87
COFKGGJM_00115 4e-170 L Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
COFKGGJM_00116 1.7e-173 L Transposase IS66 family
COFKGGJM_00117 8.1e-47 XK27_01125 L PFAM IS66 Orf2 family protein
COFKGGJM_00119 4.9e-79 UW LPXTG-motif cell wall anchor domain protein
COFKGGJM_00120 1.4e-126 L Helix-turn-helix domain
COFKGGJM_00121 9.9e-11 L Helix-turn-helix domain
COFKGGJM_00122 2.8e-290 lysS 6.1.1.6 J Belongs to the class-II aminoacyl-tRNA synthetase family
COFKGGJM_00123 2.4e-189 dus J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
COFKGGJM_00124 2.6e-169 hslO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
COFKGGJM_00125 0.0 ftsH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
COFKGGJM_00126 1.3e-96 hpt 2.4.2.8 F Belongs to the purine pyrimidine phosphoribosyltransferase family
COFKGGJM_00127 2.7e-250 tilS 2.4.2.8, 6.3.4.19 J Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
COFKGGJM_00128 9.8e-67 yabR J RNA binding
COFKGGJM_00129 1.6e-55 divIC D Septum formation initiator
COFKGGJM_00130 2.1e-39 yabO J S4 domain protein
COFKGGJM_00131 0.0 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
COFKGGJM_00132 1.3e-102 pth 3.1.1.29 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
COFKGGJM_00133 1.1e-113 S (CBS) domain
COFKGGJM_00134 6.4e-145 tesE Q hydratase
COFKGGJM_00135 5.2e-242 codA 3.5.4.1 F cytosine deaminase
COFKGGJM_00136 3.1e-251 U Belongs to the purine-cytosine permease (2.A.39) family
COFKGGJM_00137 3.2e-62 L Toxic component of a toxin-antitoxin (TA) module
COFKGGJM_00138 1.1e-209 alr 5.1.1.1 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
COFKGGJM_00139 3.2e-59 acpS 2.7.6.3, 2.7.8.7, 5.1.1.1 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
COFKGGJM_00141 8.5e-295 dltA 6.1.1.13 H Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
COFKGGJM_00142 6.7e-234 dltB M MBOAT, membrane-bound O-acyltransferase family
COFKGGJM_00143 1.7e-35 dltC 6.1.1.13 J Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
COFKGGJM_00144 1.5e-252 dltD M Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
COFKGGJM_00145 1.4e-170 glsA 3.5.1.2 E Belongs to the glutaminase family
COFKGGJM_00147 3.9e-26 cysE 2.3.1.178 J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
COFKGGJM_00148 4.8e-79
COFKGGJM_00149 9.8e-32 ykzG S Belongs to the UPF0356 family
COFKGGJM_00150 2.5e-180 ytlR 2.7.1.91 I Diacylglycerol kinase catalytic
COFKGGJM_00151 5.7e-29
COFKGGJM_00152 1.3e-122 mltD CBM50 M NlpC P60 family protein
COFKGGJM_00154 6.5e-57
COFKGGJM_00155 1.1e-206 glxK 2.7.1.165 G Belongs to the glycerate kinase type-1 family
COFKGGJM_00156 1.1e-218 EG GntP family permease
COFKGGJM_00157 8.5e-84 KT Putative sugar diacid recognition
COFKGGJM_00158 1e-198 asd 1.2.1.11 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
COFKGGJM_00159 3.8e-218 patA 2.6.1.1 E Aminotransferase
COFKGGJM_00160 3.6e-140 dapB 1.17.1.8 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
COFKGGJM_00161 1e-173 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
COFKGGJM_00162 1.1e-222 hipO 3.5.1.47 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
COFKGGJM_00163 2.7e-73 dapD 2.3.1.117, 2.3.1.89 E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
COFKGGJM_00164 6.9e-245 lysA 4.1.1.19, 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
COFKGGJM_00165 2.3e-259 lysC 2.7.2.4 E Belongs to the aspartokinase family
COFKGGJM_00166 1.4e-181 dapF 5.1.1.7 E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
COFKGGJM_00167 5.8e-172 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
COFKGGJM_00168 0.0 recD2 3.1.11.5 L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
COFKGGJM_00169 4.9e-117 S Repeat protein
COFKGGJM_00170 2.9e-122 pgm6 5.4.2.11, 5.4.2.12 G phosphoglycerate mutase
COFKGGJM_00171 2.6e-224 mnmA 2.8.1.13 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
COFKGGJM_00172 7.5e-58 XK27_04120 S Putative amino acid metabolism
COFKGGJM_00173 5.4e-217 iscS 2.8.1.7 E Aminotransferase class V
COFKGGJM_00174 5.5e-124 mtnN 3.2.2.9 E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
COFKGGJM_00176 1.1e-98 nudF 3.6.1.13 L ADP-ribose pyrophosphatase
COFKGGJM_00177 4.2e-32 cspA K Cold shock protein
COFKGGJM_00178 0.0 ileS 6.1.1.5 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
COFKGGJM_00179 1.6e-36 divIVA D DivIVA domain protein
COFKGGJM_00180 5.4e-144 ylmH S S4 domain protein
COFKGGJM_00181 3.2e-40 yggT S YGGT family
COFKGGJM_00182 9.4e-71 sepF D Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
COFKGGJM_00183 3.5e-222 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
COFKGGJM_00184 7.3e-253 ftsA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
COFKGGJM_00185 2.1e-141 divIB D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
COFKGGJM_00186 1.6e-202 murG 2.4.1.227, 6.3.2.8 GT28 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
COFKGGJM_00187 1.5e-261 murD 6.3.2.9 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
COFKGGJM_00188 1.7e-179 mraY 2.7.8.13 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
COFKGGJM_00189 0.0 ftsI 3.4.16.4 M Penicillin-binding Protein
COFKGGJM_00190 1.3e-55 ftsL D Cell division protein FtsL
COFKGGJM_00191 1.3e-171 rsmH 2.1.1.199 J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
COFKGGJM_00192 3.1e-77 mraZ K Belongs to the MraZ family
COFKGGJM_00193 1.9e-56
COFKGGJM_00194 1.2e-10 S Protein of unknown function (DUF4044)
COFKGGJM_00195 0.0 ftsK D Belongs to the FtsK SpoIIIE SftA family
COFKGGJM_00196 2.3e-95 trmL 2.1.1.207 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
COFKGGJM_00197 1e-159 rrmA 2.1.1.187 H Methyltransferase
COFKGGJM_00198 1.5e-181 pgl 3.1.1.31 G Lactonase, 7-bladed beta-propeller
COFKGGJM_00200 9.5e-39 S Cytochrome B5
COFKGGJM_00202 7e-19 1.1.1.193, 3.5.4.26 H RibD C-terminal domain
COFKGGJM_00203 1.1e-108 T Transcriptional regulatory protein, C terminal
COFKGGJM_00204 1.4e-213 T GHKL domain
COFKGGJM_00205 7.8e-77 S Peptidase propeptide and YPEB domain
COFKGGJM_00206 1.5e-65 lacA S transferase hexapeptide repeat
COFKGGJM_00207 3.7e-119 S Alpha beta hydrolase
COFKGGJM_00208 5.1e-153 tesE Q hydratase
COFKGGJM_00209 6.6e-173 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
COFKGGJM_00210 2.4e-160 ypuA S Protein of unknown function (DUF1002)
COFKGGJM_00211 2.3e-184 ansA 3.5.1.1 EJ L-asparaginase, type I
COFKGGJM_00212 7.1e-145 K Transcriptional regulator
COFKGGJM_00213 1.3e-159 akr5f 1.1.1.346 S reductase
COFKGGJM_00214 2.1e-101 qorB 1.6.5.2 GM NmrA-like family
COFKGGJM_00215 1.9e-59 yneR
COFKGGJM_00216 6.1e-128 yfeJ 6.3.5.2 F glutamine amidotransferase
COFKGGJM_00217 2.7e-138 T EAL domain
COFKGGJM_00218 3.4e-247 pgaC GT2 M Glycosyl transferase
COFKGGJM_00219 1.7e-82
COFKGGJM_00220 2.6e-195 2.7.7.65 T GGDEF domain
COFKGGJM_00221 2.8e-120 yhjH 3.1.4.52 T Putative diguanylate phosphodiesterase
COFKGGJM_00222 2.7e-257 asnS 6.1.1.22 J Asparaginyl-tRNA synthetase
COFKGGJM_00223 1.9e-197 asnA 6.3.1.1 F aspartate--ammonia ligase
COFKGGJM_00224 2.3e-24 folT S ECF transporter, substrate-specific component
COFKGGJM_00225 1.9e-48 K Transcriptional regulator
COFKGGJM_00226 0.0 pepN 3.4.11.2 E aminopeptidase
COFKGGJM_00227 4.1e-43 ylbE GM NAD dependent epimerase dehydratase family protein
COFKGGJM_00228 5.3e-60 ylbE GM NAD dependent epimerase dehydratase family protein
COFKGGJM_00229 3e-256 pepC 3.4.22.40 E aminopeptidase
COFKGGJM_00230 2.2e-210 EGP Major facilitator Superfamily
COFKGGJM_00231 2e-231
COFKGGJM_00232 4e-83 K Transcriptional regulator, HxlR family
COFKGGJM_00233 1.2e-106 XK27_02070 S Nitroreductase family
COFKGGJM_00234 1.8e-50 hxlR K Transcriptional regulator, HxlR family
COFKGGJM_00235 1.2e-120 GM NmrA-like family
COFKGGJM_00236 1.5e-74 elaA S Gnat family
COFKGGJM_00237 1.1e-28 S Cytochrome B5
COFKGGJM_00238 2e-219 yxjG_1 E methionine synthase, vitamin-B12 independent
COFKGGJM_00240 2.8e-15 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
COFKGGJM_00241 1.7e-67 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
COFKGGJM_00242 2.3e-238 E amino acid
COFKGGJM_00243 7.9e-32 npp S type I phosphodiesterase nucleotide pyrophosphatase
COFKGGJM_00244 1.8e-153 npp S type I phosphodiesterase nucleotide pyrophosphatase
COFKGGJM_00245 6.3e-52 npp S type I phosphodiesterase nucleotide pyrophosphatase
COFKGGJM_00246 9.8e-30 yxiO S Vacuole effluxer Atg22 like
COFKGGJM_00247 2.8e-56 yxiO S Vacuole effluxer Atg22 like
COFKGGJM_00248 8.6e-91 yxiO S Vacuole effluxer Atg22 like
COFKGGJM_00250 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
COFKGGJM_00251 2.3e-29
COFKGGJM_00252 8.9e-287 mntH P H( )-stimulated, divalent metal cation uptake system
COFKGGJM_00253 9.9e-191 tdh 1.1.1.14 E Alcohol dehydrogenase GroES-like domain
COFKGGJM_00254 3.7e-85 ygfC K transcriptional regulator (TetR family)
COFKGGJM_00255 3.3e-168 hrtB V ABC transporter permease
COFKGGJM_00256 1.3e-117 devA 3.6.3.25 V ABC transporter, ATP-binding protein
COFKGGJM_00257 1e-127 rnhA 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
COFKGGJM_00258 1.3e-210 mvaS 2.3.3.10 I Hydroxymethylglutaryl-CoA synthase
COFKGGJM_00259 5.5e-115 lexA 3.4.21.88 K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
COFKGGJM_00260 1.3e-35 ynzC S UPF0291 protein
COFKGGJM_00261 9.8e-30 yneF S Uncharacterised protein family (UPF0154)
COFKGGJM_00262 1.6e-117 plsC 2.3.1.51 I Acyltransferase
COFKGGJM_00263 3.5e-140 yabB 2.1.1.223 L Methyltransferase small domain
COFKGGJM_00264 7.1e-49 yazA L GIY-YIG catalytic domain protein
COFKGGJM_00265 7e-181 ldhD 1.1.1.28 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
COFKGGJM_00266 4.6e-143 rpsB J Belongs to the universal ribosomal protein uS2 family
COFKGGJM_00267 9.3e-153 tsf J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
COFKGGJM_00268 8.2e-129 pyrH 2.7.4.22 F Catalyzes the reversible phosphorylation of UMP to UDP
COFKGGJM_00269 1.4e-93 frr J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
COFKGGJM_00270 2.4e-141 uppS 2.5.1.31 H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
COFKGGJM_00271 5.8e-138 cdsA 2.7.7.41 I Belongs to the CDS family
COFKGGJM_00272 4.1e-234 rseP 3.4.21.107, 3.4.21.116 M zinc metalloprotease
COFKGGJM_00273 0.0 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
COFKGGJM_00274 0.0 polC 2.7.7.7 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
COFKGGJM_00275 9.4e-83 rimP J Required for maturation of 30S ribosomal subunits
COFKGGJM_00276 1.4e-215 nusA K Participates in both transcription termination and antitermination
COFKGGJM_00277 1e-44 ylxR K Protein of unknown function (DUF448)
COFKGGJM_00278 1.3e-48 ylxQ J ribosomal protein
COFKGGJM_00279 0.0 infB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
COFKGGJM_00280 6.1e-58 rbfA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
COFKGGJM_00281 7.1e-164 truB 5.4.99.25 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
COFKGGJM_00282 5.9e-177 ribF 2.7.1.26, 2.7.7.2 H Belongs to the ribF family
COFKGGJM_00283 2.9e-63
COFKGGJM_00284 1e-193 hrcA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
COFKGGJM_00285 1e-75 grpE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
COFKGGJM_00286 0.0 dnaK O Heat shock 70 kDa protein
COFKGGJM_00287 9.5e-198 dnaJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
COFKGGJM_00288 0.0 lepA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
COFKGGJM_00289 2e-274 pipD E Dipeptidase
COFKGGJM_00290 3.6e-199 mdh 1.1.1.350 C Belongs to the LDH2 MDH2 oxidoreductase family
COFKGGJM_00292 1.2e-172 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
COFKGGJM_00293 7.5e-58
COFKGGJM_00294 3.1e-178 prmA J Ribosomal protein L11 methyltransferase
COFKGGJM_00295 9.7e-127 rsmE 2.1.1.193 J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
COFKGGJM_00296 9.4e-50
COFKGGJM_00297 0.0 relA 2.7.6.5 KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
COFKGGJM_00298 1.9e-77 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
COFKGGJM_00299 4.6e-165 yniA G Phosphotransferase enzyme family
COFKGGJM_00300 0.0 aspS 6.1.1.12 J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
COFKGGJM_00301 1e-131 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
COFKGGJM_00302 1.1e-262 glnPH2 P ABC transporter permease
COFKGGJM_00303 1.2e-23 rpsU J Belongs to the bacterial ribosomal protein bS21 family
COFKGGJM_00304 1.1e-69 yqeY S YqeY-like protein
COFKGGJM_00305 4.9e-226 dhaT 1.1.1.1, 1.1.1.202 C Dehydrogenase
COFKGGJM_00306 2.9e-96 S reductase
COFKGGJM_00308 4.7e-88 rlmH 2.1.1.177 J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
COFKGGJM_00309 6.5e-179 ABC-SBP S ABC transporter
COFKGGJM_00310 6.8e-84 pgpA 3.1.3.27 I Phosphatidylglycerophosphatase A
COFKGGJM_00312 1.6e-214 htrA 3.4.21.107 O serine protease
COFKGGJM_00313 2.3e-153 vicX 3.1.26.11 S domain protein
COFKGGJM_00314 7.8e-149 yycI S YycH protein
COFKGGJM_00315 2.4e-245 yycH S YycH protein
COFKGGJM_00316 0.0 vicK 2.7.13.3 T Histidine kinase
COFKGGJM_00317 3.1e-130 K response regulator
COFKGGJM_00320 7.6e-308 lmrA 3.6.3.44 V ABC transporter
COFKGGJM_00321 6.8e-72 K helix_turn_helix multiple antibiotic resistance protein
COFKGGJM_00323 7.5e-96 Z012_01130 S Fic/DOC family
COFKGGJM_00325 6.9e-156 S Polyphosphate nucleotide phosphotransferase, PPK2 family
COFKGGJM_00326 3.6e-50
COFKGGJM_00327 9e-207 yttB EGP Major facilitator Superfamily
COFKGGJM_00328 1.8e-235 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
COFKGGJM_00329 2e-74 rplI J Binds to the 23S rRNA
COFKGGJM_00330 0.0 yybT T signaling protein consisting of a modified GGDEF domain and a DHH domain
COFKGGJM_00331 4.8e-99 deoR K sugar-binding domain protein
COFKGGJM_00332 1.2e-46 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
COFKGGJM_00333 8.4e-32 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
COFKGGJM_00334 1.6e-35 rpsR J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
COFKGGJM_00335 4.8e-78 ssb L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
COFKGGJM_00336 1.2e-48 rpsF J Binds together with S18 to 16S ribosomal RNA
COFKGGJM_00337 0.0 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
COFKGGJM_00338 0.0 gyrB 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
COFKGGJM_00339 1.8e-204 recF L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
COFKGGJM_00340 1.7e-34 yaaA S S4 domain protein YaaA
COFKGGJM_00341 2.8e-202 dnaN 2.7.7.7 L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
COFKGGJM_00342 1.1e-250 dnaA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
COFKGGJM_00343 3.4e-14 rpmH J Belongs to the bacterial ribosomal protein bL34 family
COFKGGJM_00344 2e-58 rnpA 3.1.26.5 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
COFKGGJM_00345 4.5e-130 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
COFKGGJM_00346 6.3e-129 jag S R3H domain protein
COFKGGJM_00347 2.8e-252 mnmE S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
COFKGGJM_00348 0.0 gidA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
COFKGGJM_00349 0.0 asnB 6.3.5.4 E Asparagine synthase
COFKGGJM_00350 9.3e-289 murE 6.3.2.13, 6.3.2.7 M Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
COFKGGJM_00351 6.4e-248 yxbA 6.3.1.12 S ATP-grasp enzyme
COFKGGJM_00352 2.9e-113 lepB 3.4.21.89 U Belongs to the peptidase S26 family
COFKGGJM_00353 2.5e-14 2.3.1.183 M Acetyltransferase GNAT family
COFKGGJM_00354 1.4e-49 2.3.1.183 M Acetyltransferase GNAT family
COFKGGJM_00355 1.5e-147 2.3.1.19 K Helix-turn-helix XRE-family like proteins
COFKGGJM_00356 3.4e-216 ddl 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
COFKGGJM_00357 1.4e-47 gcvH E glycine cleavage
COFKGGJM_00358 1.1e-220 rodA D Belongs to the SEDS family
COFKGGJM_00359 1e-31 S Protein of unknown function (DUF2969)
COFKGGJM_00360 1.9e-178 mbl D Cell shape determining protein MreB Mrl
COFKGGJM_00361 3e-240 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
COFKGGJM_00362 1.3e-33 ywzB S Protein of unknown function (DUF1146)
COFKGGJM_00363 3.8e-67 atpC C Produces ATP from ADP in the presence of a proton gradient across the membrane
COFKGGJM_00364 1.1e-267 atpD 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
COFKGGJM_00365 4.8e-163 atpG C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
COFKGGJM_00366 1.5e-283 atpA 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
COFKGGJM_00367 5.1e-93 atpH C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
COFKGGJM_00368 5.7e-57 atpF C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
COFKGGJM_00369 1.5e-14 atpE C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
COFKGGJM_00370 7.3e-124 atpB C it plays a direct role in the translocation of protons across the membrane
COFKGGJM_00371 5.9e-233 pyrP F Permease
COFKGGJM_00372 7.5e-130 yibF S overlaps another CDS with the same product name
COFKGGJM_00373 2.6e-192 yibE S overlaps another CDS with the same product name
COFKGGJM_00374 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
COFKGGJM_00375 6.6e-116 upp 2.4.2.9 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
COFKGGJM_00376 3.9e-229 glyA 2.1.2.1 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
COFKGGJM_00377 1.4e-195 ywlC 2.7.7.87, 3.1.3.48 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
COFKGGJM_00378 6.1e-165 prmB 2.1.1.297, 2.1.1.298 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
COFKGGJM_00379 1.2e-194 prfA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
COFKGGJM_00380 6e-108 tdk 2.7.1.21 F thymidine kinase
COFKGGJM_00381 4.9e-262 murD 3.4.21.10, 6.3.2.13, 6.3.2.9 M Mur ligase, middle domain
COFKGGJM_00382 1.2e-134 cobQ S CobB/CobQ-like glutamine amidotransferase domain
COFKGGJM_00383 4.4e-221 arcD U Amino acid permease
COFKGGJM_00384 2.8e-260 E Arginine ornithine antiporter
COFKGGJM_00385 2.7e-79 argR K Regulates arginine biosynthesis genes
COFKGGJM_00386 8.9e-218 arcA 3.5.3.6 E Arginine
COFKGGJM_00387 8.2e-185 ampC V Beta-lactamase
COFKGGJM_00388 7e-19
COFKGGJM_00389 2.2e-60 M domain protein
COFKGGJM_00390 2.5e-142 M domain protein
COFKGGJM_00391 5.9e-267 M domain protein
COFKGGJM_00392 7.4e-94
COFKGGJM_00394 5e-100 yjcE P Sodium proton antiporter
COFKGGJM_00395 3.2e-57 yjcE P Sodium proton antiporter
COFKGGJM_00396 1.7e-39 yjcE P Sodium proton antiporter
COFKGGJM_00397 6.8e-56
COFKGGJM_00399 3.1e-86
COFKGGJM_00400 0.0 copA 3.6.3.54 P P-type ATPase
COFKGGJM_00401 2.4e-49 silP 1.9.3.1, 3.6.3.54 S Cupredoxin-like domain
COFKGGJM_00402 1.7e-47 silP 1.9.3.1, 3.6.3.54 S Cupredoxin-like domain
COFKGGJM_00403 3.3e-161 EG EamA-like transporter family
COFKGGJM_00404 2.7e-39
COFKGGJM_00405 0.0 ydaO E amino acid
COFKGGJM_00406 2.6e-302 ybeC E amino acid
COFKGGJM_00407 5.3e-81 S Aminoacyl-tRNA editing domain
COFKGGJM_00408 5.5e-292 groL O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
COFKGGJM_00409 1.1e-43 groS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
COFKGGJM_00411 8.2e-114 rex K Modulates transcription in response to changes in cellular NADH NAD( ) redox state
COFKGGJM_00412 0.0 uup S ABC transporter, ATP-binding protein
COFKGGJM_00413 6.2e-182 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
COFKGGJM_00414 1.3e-226 mtnE 2.6.1.83 E Aminotransferase
COFKGGJM_00415 5.6e-141 mtnU 3.5.1.3 S Carbon-nitrogen hydrolase
COFKGGJM_00416 8.4e-137 proB 2.7.2.11 F Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
COFKGGJM_00417 1.2e-217 proA 1.2.1.41 E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
COFKGGJM_00418 8e-132 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
COFKGGJM_00419 2e-194 tsaD 2.3.1.234 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
COFKGGJM_00420 2.9e-99 rimI 2.3.1.128 K Ribosomal-protein-alanine acetyltransferase
COFKGGJM_00421 9.5e-127 yeaZ 2.3.1.234 O Universal bacterial protein YeaZ
COFKGGJM_00422 6.8e-192 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
COFKGGJM_00423 6.4e-171 ppx 3.6.1.11, 3.6.1.40 FP exopolyphosphatase
COFKGGJM_00424 0.0 ppk 2.7.4.1 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
COFKGGJM_00425 1.1e-281 ppx3 3.6.1.11, 3.6.1.40 FP exopolyphosphatase
COFKGGJM_00426 4.2e-133 fat 3.1.2.21 I Acyl-ACP thioesterase
COFKGGJM_00427 7.5e-155 rsmI 2.1.1.198 H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
COFKGGJM_00428 3.1e-43 yabA L Involved in initiation control of chromosome replication
COFKGGJM_00429 1.3e-182 holB 2.7.7.7 L DNA polymerase III
COFKGGJM_00430 2.9e-51 yaaQ S Cyclic-di-AMP receptor
COFKGGJM_00431 1.7e-111 tmk 2.7.4.9 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
COFKGGJM_00432 2.8e-38 S Protein of unknown function (DUF2508)
COFKGGJM_00433 6.3e-108 recR L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
COFKGGJM_00434 7e-47 yaaK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
COFKGGJM_00435 7.1e-304 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
COFKGGJM_00436 1e-87 tadA 3.5.4.33 F Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
COFKGGJM_00437 3.4e-35 nrdH O Glutaredoxin
COFKGGJM_00438 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
COFKGGJM_00439 2.2e-198 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
COFKGGJM_00440 0.0 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
COFKGGJM_00441 7.6e-115 S Putative adhesin
COFKGGJM_00442 4.3e-80 XK27_06920 S Protein of unknown function (DUF1700)
COFKGGJM_00443 8.9e-56 K transcriptional regulator PadR family
COFKGGJM_00444 3.2e-38 mscL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
COFKGGJM_00445 3.4e-48
COFKGGJM_00446 3.2e-54 rplL J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
COFKGGJM_00447 1.7e-82 rplJ J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
COFKGGJM_00448 1.3e-173 mnaA 5.1.3.14 G Belongs to the UDP-N-acetylglucosamine 2-epimerase family
COFKGGJM_00449 4.4e-198 G Transporter, major facilitator family protein
COFKGGJM_00450 6.2e-105 yvrI K sigma factor activity
COFKGGJM_00451 7.5e-59 ydiI Q Thioesterase superfamily
COFKGGJM_00452 2.9e-156 menB 4.1.3.36 H Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
COFKGGJM_00453 2.2e-268 menE 6.2.1.26 H Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily
COFKGGJM_00454 0.0 feoB P transporter of a GTP-driven Fe(2 ) uptake system
COFKGGJM_00455 2.8e-31 feoA P FeoA domain
COFKGGJM_00456 2.1e-143 sufC O FeS assembly ATPase SufC
COFKGGJM_00457 5.1e-240 sufD O FeS assembly protein SufD
COFKGGJM_00458 1.2e-233 sufS 2.8.1.7, 4.4.1.16 E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
COFKGGJM_00459 3.6e-79 nifU C SUF system FeS assembly protein, NifU family
COFKGGJM_00460 1.2e-271 sufB O assembly protein SufB
COFKGGJM_00461 6.2e-57 yitW S Iron-sulfur cluster assembly protein
COFKGGJM_00462 5.2e-159 hipB K Helix-turn-helix
COFKGGJM_00463 3.4e-115 nreC K PFAM regulatory protein LuxR
COFKGGJM_00464 9.2e-39 S Cytochrome B5
COFKGGJM_00465 1e-153 yitU 3.1.3.104 S hydrolase
COFKGGJM_00466 3.7e-257 rsmF 2.1.1.176, 2.1.1.178 J NOL1 NOP2 sun family protein
COFKGGJM_00467 4e-148 f42a O Band 7 protein
COFKGGJM_00468 2.5e-49 lytS 2.7.13.3 T LytS YhcK-type transmembrane receptor domain protein
COFKGGJM_00469 2.4e-110 lytS 2.7.13.3 T LytS YhcK-type transmembrane receptor domain protein
COFKGGJM_00470 2.6e-118 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
COFKGGJM_00471 2.2e-170 scrK 2.7.1.2, 2.7.1.4 GK ROK family
COFKGGJM_00472 3.7e-185 galR K Periplasmic binding protein-like domain
COFKGGJM_00473 0.0 rafA 3.2.1.22 G alpha-galactosidase
COFKGGJM_00474 6.5e-134 L Transposase
COFKGGJM_00475 1.7e-100 L Transposase
COFKGGJM_00476 9.3e-86 S Protein of unknown function (DUF1440)
COFKGGJM_00477 3.2e-192 fni 1.1.1.88, 5.3.3.2 C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
COFKGGJM_00478 2.1e-213 mvaK2 2.7.1.36, 2.7.1.43, 2.7.4.2 I phosphomevalonate kinase
COFKGGJM_00479 3.7e-166 mvaD 4.1.1.33 I diphosphomevalonate decarboxylase
COFKGGJM_00480 6.3e-171 mvk 1.1.1.88, 2.3.3.10, 2.7.1.36 I mevalonate kinase
COFKGGJM_00481 0.0 dinG 2.7.7.7, 3.6.4.12 L helicase involved in DNA repair and perhaps also replication
COFKGGJM_00482 1.5e-86 ypmB S Protein conserved in bacteria
COFKGGJM_00483 8.1e-123 dnaD L DnaD domain protein
COFKGGJM_00484 1.3e-160 EG EamA-like transporter family
COFKGGJM_00485 0.0 ponA 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein 1A
COFKGGJM_00486 8.3e-116 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
COFKGGJM_00487 3.2e-101 ypsA S Belongs to the UPF0398 family
COFKGGJM_00488 1.2e-42 gpsB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
COFKGGJM_00489 8e-82 F Belongs to the NrdI family
COFKGGJM_00490 9.5e-222 rlmL 2.1.1.173, 2.1.1.264 L Belongs to the methyltransferase superfamily
COFKGGJM_00491 1.6e-109 dedA S SNARE-like domain protein
COFKGGJM_00492 2.8e-101 S Protein of unknown function (DUF1461)
COFKGGJM_00493 9.4e-133 nagD 2.7.1.25, 3.1.3.41 G Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
COFKGGJM_00494 6.6e-93 yutD S Protein of unknown function (DUF1027)
COFKGGJM_00495 6.1e-111 S Calcineurin-like phosphoesterase
COFKGGJM_00496 1.3e-221 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
COFKGGJM_00497 9.4e-144 ytxK 2.1.1.72 L N-6 DNA Methylase
COFKGGJM_00499 2e-68
COFKGGJM_00500 7.9e-40
COFKGGJM_00501 2.4e-77 NU general secretion pathway protein
COFKGGJM_00502 7.1e-47 comGC U competence protein ComGC
COFKGGJM_00503 4.3e-181 comGB NU type II secretion system
COFKGGJM_00504 4.8e-182 comGA NU Type II IV secretion system protein
COFKGGJM_00505 5.9e-132 yebC K Transcriptional regulatory protein
COFKGGJM_00506 3e-132
COFKGGJM_00507 1e-179 ccpA K catabolite control protein A
COFKGGJM_00508 2.3e-209 pepQ 3.4.13.9 E Creatinase/Prolidase N-terminal domain
COFKGGJM_00509 4.3e-16
COFKGGJM_00510 9.4e-37 WQ51_05790 S protein containing a divergent version of the methyl-accepting chemotaxis-like domain
COFKGGJM_00511 6.9e-148 ykuT M mechanosensitive ion channel
COFKGGJM_00512 1.8e-153 3.1.3.102, 3.1.3.104, 3.1.3.23 S haloacid dehalogenase-like hydrolase
COFKGGJM_00513 1.1e-74 ykuL S (CBS) domain
COFKGGJM_00514 3.4e-94 S Phosphoesterase
COFKGGJM_00515 3.7e-105 rdgB 3.6.1.66, 5.1.1.3 F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
COFKGGJM_00516 3.1e-147 murI 3.6.1.66, 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
COFKGGJM_00517 3e-96 yslB S Protein of unknown function (DUF2507)
COFKGGJM_00518 6.1e-54 trxA O Belongs to the thioredoxin family
COFKGGJM_00519 0.0 mutS2 L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
COFKGGJM_00520 2.7e-86 cvpA S Colicin V production protein
COFKGGJM_00521 6.1e-48 yrzB S Belongs to the UPF0473 family
COFKGGJM_00522 3.6e-76 yqgF J Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
COFKGGJM_00523 4.1e-43 yrzL S Belongs to the UPF0297 family
COFKGGJM_00524 0.0 alaS 6.1.1.7 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
COFKGGJM_00525 3.7e-233 cshB 3.6.4.13 JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
COFKGGJM_00526 2.1e-182 nrnA 3.1.13.3, 3.1.3.7 S DHHA1 domain protein
COFKGGJM_00527 9e-30 yajC U Preprotein translocase
COFKGGJM_00528 2.2e-188 tgt_1 2.4.2.29 F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
COFKGGJM_00529 6.5e-190 ruvB 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
COFKGGJM_00530 2.1e-100 ruvA 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
COFKGGJM_00531 0.0 mutL L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
COFKGGJM_00532 0.0 mutS L that it carries out the mismatch recognition step. This protein has a weak ATPase activity
COFKGGJM_00533 9.5e-209 rny S Endoribonuclease that initiates mRNA decay
COFKGGJM_00534 1.7e-196 recA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
COFKGGJM_00535 3.6e-227 cinA 3.5.1.42 S Belongs to the CinA family
COFKGGJM_00536 5.5e-101 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
COFKGGJM_00537 3.8e-137 ymfM S Helix-turn-helix domain
COFKGGJM_00538 2.3e-248 ymfH S Peptidase M16
COFKGGJM_00539 2.6e-225 ymfF S Peptidase M16 inactive domain protein
COFKGGJM_00540 1.7e-159 aatB ET ABC transporter substrate-binding protein
COFKGGJM_00541 1.2e-117 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
COFKGGJM_00542 3.2e-102 glnP P ABC transporter permease
COFKGGJM_00543 8.7e-93 mreD M rod shape-determining protein MreD
COFKGGJM_00544 3.5e-152 mreC M Involved in formation and maintenance of cell shape
COFKGGJM_00545 1.7e-179 mreB D cell shape determining protein MreB
COFKGGJM_00546 8e-122 radC L DNA repair protein
COFKGGJM_00547 2.5e-242 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
COFKGGJM_00548 1.8e-231 ndh 1.6.99.3 C NADH dehydrogenase
COFKGGJM_00549 0.0 cydD CO ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
COFKGGJM_00550 2.3e-311 cydD CO ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydD
COFKGGJM_00551 4.5e-183 cydB 1.10.3.14 C Cytochrome d ubiquinol oxidase subunit II
COFKGGJM_00552 7.2e-272 cydA 1.10.3.14 C ubiquinol oxidase
COFKGGJM_00553 0.0 valS 6.1.1.9 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
COFKGGJM_00554 3.2e-228 thiI 2.8.1.4 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
COFKGGJM_00555 2.3e-215 iscS2 2.8.1.7 E Aminotransferase class V
COFKGGJM_00556 2.5e-239 ezrA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
COFKGGJM_00557 3.7e-108 rpsD J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
COFKGGJM_00558 2.4e-66 gadC E amino acid
COFKGGJM_00559 1.1e-157 gadC E amino acid
COFKGGJM_00560 4.8e-276 gadB 4.1.1.15 E Belongs to the group II decarboxylase family
COFKGGJM_00561 1.1e-234 pbuG S permease
COFKGGJM_00562 2.5e-258 frc 2.8.3.16 C Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate
COFKGGJM_00563 1.5e-32 oxc 4.1.1.8 EH Belongs to the TPP enzyme family
COFKGGJM_00564 1.1e-33 oxc 4.1.1.8 EH Belongs to the TPP enzyme family
COFKGGJM_00565 9.9e-186 oxc 4.1.1.8 EH Belongs to the TPP enzyme family
COFKGGJM_00566 5e-139 S Belongs to the UPF0246 family
COFKGGJM_00567 2.5e-138 S Membrane
COFKGGJM_00568 8.1e-75 4.4.1.5 E Glyoxalase
COFKGGJM_00569 1.4e-19
COFKGGJM_00570 3.5e-85 yueI S Protein of unknown function (DUF1694)
COFKGGJM_00571 6.1e-241 rarA L recombination factor protein RarA
COFKGGJM_00572 5.7e-46
COFKGGJM_00573 4.3e-83 usp6 T universal stress protein
COFKGGJM_00574 3.3e-160 xth 3.1.11.2 L exodeoxyribonuclease III
COFKGGJM_00575 1.2e-52 S Mazg nucleotide pyrophosphohydrolase
COFKGGJM_00576 1.4e-33
COFKGGJM_00577 3.6e-64 rplS J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
COFKGGJM_00578 1.2e-186 yfnA E amino acid
COFKGGJM_00579 3.5e-49 yfnA E amino acid
COFKGGJM_00580 9.9e-143 trmD 2.1.1.228, 4.6.1.12 J Belongs to the RNA methyltransferase TrmD family
COFKGGJM_00581 7.6e-91 rimM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
COFKGGJM_00582 7e-40 ylqC S Belongs to the UPF0109 family
COFKGGJM_00583 6.5e-44 rpsP J Belongs to the bacterial ribosomal protein bS16 family
COFKGGJM_00584 1.8e-249 ffh 3.6.5.4 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
COFKGGJM_00585 1.3e-57 ylxM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
COFKGGJM_00586 1.7e-178 ftsY U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
COFKGGJM_00587 0.0 smc D Required for chromosome condensation and partitioning
COFKGGJM_00588 1.2e-131 rnc 3.1.26.3 J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
COFKGGJM_00589 2.9e-38 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
COFKGGJM_00590 1e-187 plsX 2.3.1.15 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
COFKGGJM_00591 0.0 recG 3.6.4.12 L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
COFKGGJM_00592 0.0 yloV S DAK2 domain fusion protein YloV
COFKGGJM_00593 4.7e-58 asp S Asp23 family, cell envelope-related function
COFKGGJM_00594 7e-26 rpmB J Belongs to the bacterial ribosomal protein bL28 family
COFKGGJM_00595 2.4e-121 thiN 2.7.6.2 H thiamine pyrophosphokinase
COFKGGJM_00596 4.2e-118 rpe 5.1.3.1 G Belongs to the ribulose-phosphate 3-epimerase family
COFKGGJM_00597 6.5e-162 rsgA 3.1.3.100 S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
COFKGGJM_00598 0.0 KLT serine threonine protein kinase
COFKGGJM_00599 6.1e-129 stp 3.1.3.16 T phosphatase
COFKGGJM_00600 3.8e-246 sun 2.1.1.176 J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
COFKGGJM_00601 1.4e-173 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
COFKGGJM_00602 0.0 priA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
COFKGGJM_00603 6.2e-208 coaBC 4.1.1.36, 6.3.2.5 H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
COFKGGJM_00604 7.7e-32 rpoZ 2.7.7.6 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
COFKGGJM_00605 1.8e-113 gmk 2.7.4.8 F Essential for recycling GMP and indirectly, cGMP
COFKGGJM_00606 4.2e-53
COFKGGJM_00607 1.6e-262 recN L May be involved in recombinational repair of damaged DNA
COFKGGJM_00608 7.3e-77 argR K Regulates arginine biosynthesis genes
COFKGGJM_00609 1.7e-148 rrmJ 2.1.1.226, 2.1.1.227 J Ribosomal RNA large subunit methyltransferase J
COFKGGJM_00610 3.2e-153 ispA 2.5.1.1, 2.5.1.10, 2.5.1.29, 2.5.1.90 H Belongs to the FPP GGPP synthase family
COFKGGJM_00611 1.3e-42 xseB 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
COFKGGJM_00612 1.2e-215 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
COFKGGJM_00613 3.7e-146 folD 1.5.1.5, 3.5.4.9 F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
COFKGGJM_00614 6.8e-69 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
COFKGGJM_00615 2.2e-70 yqhY S Asp23 family, cell envelope-related function
COFKGGJM_00616 1.1e-113 J 2'-5' RNA ligase superfamily
COFKGGJM_00617 9.5e-200 pepP 3.4.11.9, 3.4.13.9 E Creatinase/Prolidase N-terminal domain
COFKGGJM_00618 8.4e-128 yggS S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
COFKGGJM_00619 1.3e-44 rpmA J Belongs to the bacterial ribosomal protein bL27 family
COFKGGJM_00620 2.4e-53 ysxB J Cysteine protease Prp
COFKGGJM_00621 1.5e-49 rplU J This protein binds to 23S rRNA in the presence of protein L20
COFKGGJM_00622 2e-09 IQ KR domain
COFKGGJM_00623 4e-34 IQ KR domain
COFKGGJM_00624 9.9e-58 IQ KR domain
COFKGGJM_00625 3.3e-133 S membrane transporter protein
COFKGGJM_00626 1.3e-96 S ABC-type cobalt transport system, permease component
COFKGGJM_00627 4.9e-249 cbiO1 S ABC transporter, ATP-binding protein
COFKGGJM_00628 6.6e-111 P Cobalt transport protein
COFKGGJM_00629 1.6e-52 yvlA
COFKGGJM_00630 0.0 yjcE P Sodium proton antiporter
COFKGGJM_00631 6.4e-52 ypaA S Protein of unknown function (DUF1304)
COFKGGJM_00632 2e-172 D Alpha beta
COFKGGJM_00633 1e-72 K Transcriptional regulator
COFKGGJM_00634 8.5e-159
COFKGGJM_00635 2e-86 1.6.5.5 C Zinc-binding dehydrogenase
COFKGGJM_00636 9.8e-23 1.6.5.5 C Zinc-binding dehydrogenase
COFKGGJM_00637 7.2e-256 G PTS system Galactitol-specific IIC component
COFKGGJM_00638 2.6e-211 EGP Major facilitator Superfamily
COFKGGJM_00639 4.4e-134 V ABC transporter
COFKGGJM_00640 1.8e-38
COFKGGJM_00641 5.8e-59
COFKGGJM_00642 4e-14
COFKGGJM_00643 7.1e-63
COFKGGJM_00644 6.7e-195 lplA 6.3.1.20 H Lipoate-protein ligase
COFKGGJM_00645 5.1e-81 uspA T universal stress protein
COFKGGJM_00646 0.0 tetP J elongation factor G
COFKGGJM_00647 2.9e-165 GK ROK family
COFKGGJM_00648 1.6e-236 brnQ U Component of the transport system for branched-chain amino acids
COFKGGJM_00649 1.2e-137 aroD S Serine hydrolase (FSH1)
COFKGGJM_00650 1.2e-236 yagE E amino acid
COFKGGJM_00651 0.0 xfp 4.1.2.22, 4.1.2.9 G Phosphoketolase
COFKGGJM_00652 4.7e-126 gntR K UbiC transcription regulator-associated domain protein
COFKGGJM_00653 1.6e-85 ybaK J Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
COFKGGJM_00654 2.6e-269 pipD E Dipeptidase
COFKGGJM_00655 0.0 rtpR 1.1.98.6, 1.17.4.1, 1.17.4.2 F ribonucleoside-triphosphate reductase activity
COFKGGJM_00656 0.0 yfiC V ABC transporter
COFKGGJM_00657 9.8e-287 lmrA V ABC transporter, ATP-binding protein
COFKGGJM_00658 1.7e-17 K Winged helix DNA-binding domain
COFKGGJM_00659 1.6e-178 ldhA 1.1.1.28 C Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
COFKGGJM_00660 2.9e-19 S PFAM Archaeal ATPase
COFKGGJM_00661 5.9e-73 S ECF transporter, substrate-specific component
COFKGGJM_00662 9.8e-51 S Domain of unknown function (DUF4430)
COFKGGJM_00663 5.2e-17 cnrT EG PFAM EamA-like transporter family
COFKGGJM_00664 8.6e-20 cnrT EG PFAM EamA-like transporter family
COFKGGJM_00665 3.3e-203 camS S sex pheromone
COFKGGJM_00666 0.0 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
COFKGGJM_00667 0.0 pcrA 3.6.4.12 L ATP-dependent DNA helicase
COFKGGJM_00668 1.5e-211 purK2 6.3.4.18 F Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
COFKGGJM_00669 2.3e-99 xpt 2.4.2.22, 2.4.2.7 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
COFKGGJM_00670 3e-113 acmC 3.2.1.96 NU mannosyl-glycoprotein
COFKGGJM_00671 8e-140 IQ reductase
COFKGGJM_00672 5.6e-65 rpsI J Belongs to the universal ribosomal protein uS9 family
COFKGGJM_00673 4.5e-79 rplM J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
COFKGGJM_00674 9.4e-141 truA 5.4.99.12 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
COFKGGJM_00675 9.8e-141 ecfT U Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
COFKGGJM_00676 3.3e-150 ecfA2 3.6.3.55 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
COFKGGJM_00677 3.2e-139 ecfA1 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
COFKGGJM_00678 1.5e-62 rplQ J Ribosomal protein L17
COFKGGJM_00679 2.8e-171 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
COFKGGJM_00680 2.3e-63 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
COFKGGJM_00681 6.2e-58 rpsM J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
COFKGGJM_00682 1.4e-14 rpmJ J Belongs to the bacterial ribosomal protein bL36 family
COFKGGJM_00683 1.2e-32 infA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
COFKGGJM_00684 4.4e-123 adk 2.7.4.3 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
COFKGGJM_00685 2.6e-239 secY U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
COFKGGJM_00686 1.5e-63 rplO J Binds to the 23S rRNA
COFKGGJM_00687 2.9e-24 rpmD J Ribosomal protein L30
COFKGGJM_00688 6.3e-85 rpsE J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
COFKGGJM_00689 6.6e-57 rplR J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
COFKGGJM_00690 2.1e-94 rplF J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
COFKGGJM_00691 1.3e-66 rpsH J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
COFKGGJM_00692 4e-29 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
COFKGGJM_00693 1.4e-95 rplE J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
COFKGGJM_00694 2.6e-49 rplX J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
COFKGGJM_00695 1.1e-59 rplN J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
COFKGGJM_00696 5e-41 rpsQ J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
COFKGGJM_00697 8.4e-28 rpmC J Belongs to the universal ribosomal protein uL29 family
COFKGGJM_00698 3.5e-76 rplP J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
COFKGGJM_00699 6.1e-112 rpsC J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
COFKGGJM_00700 2.8e-52 rplV J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
COFKGGJM_00701 1.4e-46 rpsS J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
COFKGGJM_00702 4.2e-150 rplB J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
COFKGGJM_00703 5.7e-46 rplW J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
COFKGGJM_00704 5.5e-107 rplD J Forms part of the polypeptide exit tunnel
COFKGGJM_00705 1.5e-118 rplC J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
COFKGGJM_00706 3.4e-49 rpsJ J Involved in the binding of tRNA to the ribosomes
COFKGGJM_00707 0.0 fusA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
COFKGGJM_00708 2.4e-83 rpsG J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
COFKGGJM_00709 3.9e-72 rpsL J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
COFKGGJM_00710 6.6e-106 pilD 3.4.23.43 NOU Type II secretory pathway prepilin signal peptidase PulO and related peptidases
COFKGGJM_00711 2.3e-199 ykiI
COFKGGJM_00712 0.0 rpoC 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
COFKGGJM_00713 0.0 rpoB 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
COFKGGJM_00714 2.6e-17 S Acyltransferase family
COFKGGJM_00715 1.7e-79
COFKGGJM_00716 2.1e-145 rfbJ M Glycosyl transferase family 2
COFKGGJM_00717 1.6e-135
COFKGGJM_00718 0.0 3.2.1.17 NU Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
COFKGGJM_00719 2.2e-162 rfbA 2.7.7.24 H Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
COFKGGJM_00720 4.2e-109 rfbC 5.1.3.13 M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
COFKGGJM_00721 2.3e-198 rfbB 4.2.1.46 M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
COFKGGJM_00722 2e-157 rfbD 1.1.1.133, 5.1.3.13 M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
COFKGGJM_00723 0.0 csd1 3.5.1.28 G domain, Protein
COFKGGJM_00724 1.1e-163 yueF S AI-2E family transporter
COFKGGJM_00725 2.3e-228 brpA K Cell envelope-like function transcriptional attenuator common domain protein
COFKGGJM_00726 1.1e-308 prfC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
COFKGGJM_00727 0.0 M NlpC/P60 family
COFKGGJM_00728 0.0 S Peptidase, M23
COFKGGJM_00729 0.0 bamA GM domain, Protein
COFKGGJM_00730 1.2e-64 gntR1 K Transcriptional regulator, GntR family
COFKGGJM_00731 1.2e-155 V ABC transporter, ATP-binding protein
COFKGGJM_00732 1.9e-116
COFKGGJM_00733 3e-141 manA 1.14.13.81, 5.3.1.8, 5.4.2.8 G MucBP domain
COFKGGJM_00734 3.5e-98 S Pfam:DUF3816
COFKGGJM_00735 0.0 clpE O Belongs to the ClpA ClpB family
COFKGGJM_00736 2.9e-27
COFKGGJM_00737 2.7e-39 ptsH G phosphocarrier protein HPR
COFKGGJM_00739 2e-280 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
COFKGGJM_00740 1.4e-228 mgs 2.4.1.337 GT4 M Glycosyltransferase, group 1 family protein
COFKGGJM_00741 2.2e-198 cpoA GT4 M Glycosyltransferase, group 1 family protein
COFKGGJM_00742 1.3e-179 mprF I Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
COFKGGJM_00743 3.3e-39 ykuJ S Protein of unknown function (DUF1797)
COFKGGJM_00753 2.3e-143 L Belongs to the 'phage' integrase family
COFKGGJM_00754 1.4e-51 V Abi-like protein
COFKGGJM_00755 1.4e-27 S Domain of unknown function (DUF4352)
COFKGGJM_00756 8.3e-20 E Zn peptidase
COFKGGJM_00757 6e-15 XK27_10050 K Peptidase S24-like
COFKGGJM_00759 8.8e-40
COFKGGJM_00763 5.4e-33 S Siphovirus Gp157
COFKGGJM_00764 1.2e-157 res L Helicase C-terminal domain protein
COFKGGJM_00765 2.7e-86 L AAA domain
COFKGGJM_00767 4.4e-31
COFKGGJM_00768 1.8e-83 S Bifunctional DNA primase/polymerase, N-terminal
COFKGGJM_00769 2.2e-118 S Virulence-associated protein E
COFKGGJM_00771 1.7e-57 S VRR_NUC
COFKGGJM_00774 6.1e-17
COFKGGJM_00777 4.7e-36
COFKGGJM_00778 9.4e-80 arpU S Phage transcriptional regulator, ArpU family
COFKGGJM_00779 5.7e-117 C Domain of unknown function (DUF4145)
COFKGGJM_00781 2.1e-36 L Terminase small subunit
COFKGGJM_00783 2.9e-240 S Phage terminase, large subunit
COFKGGJM_00784 1.2e-162 S Phage portal protein
COFKGGJM_00785 1.4e-233 S Phage Mu protein F like protein
COFKGGJM_00787 8.2e-33 S YjcQ protein
COFKGGJM_00788 1.3e-23 S aminoacyl-tRNA ligase activity
COFKGGJM_00789 1.2e-96
COFKGGJM_00790 2.6e-54 S Phage gp6-like head-tail connector protein
COFKGGJM_00791 1.3e-43
COFKGGJM_00792 1.6e-67 S Bacteriophage HK97-gp10, putative tail-component
COFKGGJM_00793 8.4e-21 S Protein of unknown function (DUF3168)
COFKGGJM_00794 5e-102 S Phage tail tube protein
COFKGGJM_00795 2.5e-53 S Phage tail assembly chaperone protein, TAC
COFKGGJM_00796 2.3e-54
COFKGGJM_00797 1.1e-73 D Phage tail tape measure protein, TP901 family
COFKGGJM_00798 6.3e-145 S phage tail
COFKGGJM_00799 0.0 M Prophage endopeptidase tail
COFKGGJM_00801 8.1e-143 E GDSL-like Lipase/Acylhydrolase
COFKGGJM_00803 6e-76 S Bacteriophage holin family
COFKGGJM_00804 8.5e-184 M lysozyme activity
COFKGGJM_00805 2.6e-40 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
COFKGGJM_00806 9.4e-250 der 1.1.1.399, 1.1.1.95 S GTPase that plays an essential role in the late steps of ribosome biogenesis
COFKGGJM_00807 1.4e-205 rpsA 1.17.7.4 J Ribosomal protein S1
COFKGGJM_00808 3.8e-117 cmk 1.17.7.4, 2.5.1.19, 2.7.1.26, 2.7.4.25, 2.7.7.2, 6.3.2.1 F Belongs to the cytidylate kinase family. Type 1 subfamily
COFKGGJM_00809 2.5e-13 M Lysin motif
COFKGGJM_00810 6.4e-268 recQ1 3.6.4.12 L ATP-dependent DNA helicase RecQ
COFKGGJM_00811 8.8e-195 ypbB 5.1.3.1 S Helix-turn-helix domain
COFKGGJM_00812 2.1e-100 U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
COFKGGJM_00813 1e-128 rluB 5.4.99.19, 5.4.99.21, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
COFKGGJM_00814 1.7e-105 scpB D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
COFKGGJM_00815 2.5e-136 scpA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
COFKGGJM_00816 2.8e-63 ribT K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
COFKGGJM_00817 1.1e-161 xerD D recombinase XerD
COFKGGJM_00818 3.9e-167 cvfB S S1 domain
COFKGGJM_00819 1.4e-270 pyk 2.7.1.40, 2.7.7.4 G Belongs to the pyruvate kinase family
COFKGGJM_00820 0.0 dnaE 2.7.7.7 L DNA polymerase
COFKGGJM_00821 2e-29 S Protein of unknown function (DUF2929)
COFKGGJM_00822 6.6e-237 pepT 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
COFKGGJM_00823 4.2e-155 yqfO 3.5.4.16 S Belongs to the GTP cyclohydrolase I type 2 NIF3 family
COFKGGJM_00824 6.2e-123 trmK 2.1.1.217 S SAM-dependent methyltransferase
COFKGGJM_00825 2.4e-220 patA 2.6.1.1 E Aminotransferase
COFKGGJM_00826 2.9e-207 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
COFKGGJM_00827 0.0 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
COFKGGJM_00828 0.0 glyS 6.1.1.14 J Glycyl-tRNA synthetase beta subunit
COFKGGJM_00829 2.9e-179 glyQ 6.1.1.14 J glycyl-tRNA synthetase alpha subunit
COFKGGJM_00830 8.4e-145 recO L Involved in DNA repair and RecF pathway recombination
COFKGGJM_00831 9.6e-169 era S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
COFKGGJM_00832 3.8e-61 dgkA 2.7.1.107, 2.7.1.66 M Diacylglycerol kinase
COFKGGJM_00833 3.3e-83 ybeY 2.6.99.2, 3.5.4.5 S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
COFKGGJM_00834 4.5e-183 phoH T phosphate starvation-inducible protein PhoH
COFKGGJM_00835 1.4e-170 birA 6.3.4.15 H Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
COFKGGJM_00836 3.8e-83 bioY S BioY family
COFKGGJM_00837 6e-263 argH 4.3.2.1 E argininosuccinate lyase
COFKGGJM_00838 2.9e-237 argG 6.3.4.5 E Belongs to the argininosuccinate synthase family. Type 1 subfamily
COFKGGJM_00839 1.2e-185 cbh 3.5.1.24 M Linear amide C-N hydrolase, choloylglycine hydrolase family protein
COFKGGJM_00840 2.3e-76 L Eco57I restriction-modification methylase
COFKGGJM_00841 6.5e-75 2.1.1.72 V site-specific DNA-methyltransferase (adenine-specific) activity
COFKGGJM_00842 1.1e-25 K Cro/C1-type HTH DNA-binding domain
COFKGGJM_00843 5.7e-113 L DEAD-like helicases superfamily
COFKGGJM_00844 2.4e-19 S Domain of unknown function (DUF1837)
COFKGGJM_00845 2.5e-72 K DNA-templated transcription, initiation
COFKGGJM_00846 5.3e-27
COFKGGJM_00847 4.4e-44
COFKGGJM_00848 8.5e-215 L Protein of unknown function (DUF2800)
COFKGGJM_00849 7.8e-97 S Protein of unknown function (DUF2815)
COFKGGJM_00850 0.0 polA_2 2.7.7.7 L DNA polymerase
COFKGGJM_00851 7.4e-70 S Psort location Cytoplasmic, score
COFKGGJM_00852 0.0 S Phage plasmid primase, P4
COFKGGJM_00853 7.1e-46 S VRR_NUC
COFKGGJM_00854 3.8e-254 L SNF2 family N-terminal domain
COFKGGJM_00855 8.9e-86
COFKGGJM_00856 3.1e-98
COFKGGJM_00857 1.1e-228 2.1.1.72 KL DNA methylase
COFKGGJM_00858 7.4e-112 S Psort location Cytoplasmic, score
COFKGGJM_00859 1.8e-30 S Domain of unknown function (DUF5049)
COFKGGJM_00860 1.5e-305 S overlaps another CDS with the same product name
COFKGGJM_00861 1.4e-242 S Phage portal protein
COFKGGJM_00862 1.4e-119 clpP 3.4.21.92 OU Belongs to the peptidase S14 family
COFKGGJM_00863 2.7e-216 S Phage capsid family
COFKGGJM_00864 4.3e-43 S Phage gp6-like head-tail connector protein
COFKGGJM_00865 6.9e-68 S Phage head-tail joining protein
COFKGGJM_00866 1.8e-69 S Bacteriophage holin family
COFKGGJM_00867 2.7e-144 M Glycosyl hydrolases family 25
COFKGGJM_00868 3.6e-27
COFKGGJM_00869 1.1e-276 L Recombinase zinc beta ribbon domain
COFKGGJM_00870 4e-279 L Recombinase
COFKGGJM_00871 1.2e-74 S Domain of unknown function (DUF3841)
COFKGGJM_00872 9.2e-124 L Mrr N-terminal domain
COFKGGJM_00873 3.3e-261 rumA 2.1.1.190 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
COFKGGJM_00874 3e-187 yegS 2.7.1.107 G Lipid kinase
COFKGGJM_00875 9.1e-275 gatB 6.1.1.12, 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
COFKGGJM_00876 7.7e-277 gatA 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
COFKGGJM_00877 2.4e-50 gatC 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
COFKGGJM_00878 1e-70 wbbI M transferase activity, transferring glycosyl groups
COFKGGJM_00879 1.5e-41
COFKGGJM_00880 6.8e-146 rgpAc GT4 M Domain of unknown function (DUF1972)
COFKGGJM_00881 7.8e-199 rfbB 4.2.1.46 M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
COFKGGJM_00882 5.5e-109 rfbC 5.1.3.13 M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
COFKGGJM_00883 4.1e-161 rfbA 2.7.7.24 H Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
COFKGGJM_00884 2e-107 rfbP M Bacterial sugar transferase
COFKGGJM_00885 5.2e-120 ywqD 2.7.10.1 D Capsular exopolysaccharide family
COFKGGJM_00886 1.9e-142 epsB M biosynthesis protein
COFKGGJM_00887 8.4e-166 brpA K Cell envelope-like function transcriptional attenuator common domain protein
COFKGGJM_00888 1.3e-08 K Transcriptional regulator, HxlR family
COFKGGJM_00889 1.1e-34
COFKGGJM_00890 2.2e-90
COFKGGJM_00891 1.9e-291 glpK 2.7.1.30 F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
COFKGGJM_00892 2.7e-25 dmpI 5.3.2.6 G Belongs to the 4-oxalocrotonate tautomerase family
COFKGGJM_00893 0.0 yjbQ P TrkA C-terminal domain protein
COFKGGJM_00894 2.1e-271 pipD E Dipeptidase
COFKGGJM_00895 5.8e-199 tnp2 L PFAM Transposase, IS204 IS1001 IS1096 IS1165
COFKGGJM_00896 0.0 trxB2 1.8.1.9 C Thioredoxin domain
COFKGGJM_00897 1.2e-105 ahpC 1.11.1.15 O Peroxiredoxin
COFKGGJM_00898 9.7e-142 sdaAA 4.3.1.17 E L-serine dehydratase, iron-sulfur-dependent, alpha subunit
COFKGGJM_00899 5.4e-121 sdaAB 4.3.1.17 E Serine dehydratase beta chain
COFKGGJM_00902 7.2e-185 L transposase, IS605 OrfB family
COFKGGJM_00903 4.2e-51 L Transposase IS200 like
COFKGGJM_00904 7e-43 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
COFKGGJM_00905 2.4e-166 T Calcineurin-like phosphoesterase superfamily domain
COFKGGJM_00906 1.8e-223 mdtG EGP Major facilitator Superfamily
COFKGGJM_00907 1.3e-128 menG 2.1.1.163, 2.1.1.201 H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)
COFKGGJM_00908 3.8e-87 yxjG_1 E methionine synthase, vitamin-B12 independent
COFKGGJM_00909 4.4e-158 menA 2.5.1.74 H 1,4-dihydroxy-2-naphthoate
COFKGGJM_00910 3.2e-178 hepT 2.5.1.30, 2.5.1.90 H Belongs to the FPP GGPP synthase family
COFKGGJM_00911 0.0 lacZ 3.2.1.23 G -beta-galactosidase
COFKGGJM_00912 0.0 lacS G Transporter
COFKGGJM_00913 2.6e-186 lacR K Transcriptional regulator
COFKGGJM_00914 1.4e-101 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
COFKGGJM_00915 1.3e-207 pdhA 1.2.4.1, 1.2.4.4 C Dehydrogenase E1 component
COFKGGJM_00916 2.4e-181 pdhB 1.2.4.1 C Transketolase, C-terminal domain protein
COFKGGJM_00917 1.7e-222 pdhC 2.3.1.12 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
COFKGGJM_00918 1.4e-275 lpdA 1.8.1.4 C Dehydrogenase
COFKGGJM_00919 1.7e-45 yktA S Belongs to the UPF0223 family
COFKGGJM_00920 3.5e-135 suhB 3.1.3.25 G Belongs to the inositol monophosphatase superfamily
COFKGGJM_00921 0.0 typA T GTP-binding protein TypA
COFKGGJM_00922 1e-221 ftsW D Belongs to the SEDS family
COFKGGJM_00923 3e-44 ylbG S Uncharacterized protein conserved in bacteria (DUF2129)
COFKGGJM_00924 1.6e-97 rsmD 2.1.1.171 L RNA methyltransferase, RsmD family
COFKGGJM_00925 5.1e-90 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
COFKGGJM_00926 1.9e-197 ylbL T Belongs to the peptidase S16 family
COFKGGJM_00927 5.8e-80 comEA L Competence protein ComEA
COFKGGJM_00928 3.1e-89 comEB 3.5.4.12 F ComE operon protein 2
COFKGGJM_00929 0.0 comEC S Competence protein ComEC
COFKGGJM_00930 3.1e-147 holA 2.7.7.7 L DNA polymerase III delta subunit
COFKGGJM_00931 5.1e-35 rpsT J Binds directly to 16S ribosomal RNA
COFKGGJM_00932 1.6e-42 rpsO J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
COFKGGJM_00933 0.0 rnjB J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
COFKGGJM_00934 7.1e-164 S Tetratricopeptide repeat
COFKGGJM_00935 3.8e-226 tuf J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
COFKGGJM_00936 2.8e-238 tig D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
COFKGGJM_00937 1.8e-234 clpX O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
COFKGGJM_00938 1e-107 engB D Necessary for normal cell division and for the maintenance of normal septation
COFKGGJM_00939 6.1e-60 MA20_27270 S mazG nucleotide pyrophosphohydrolase
COFKGGJM_00940 7.6e-09
COFKGGJM_00941 0.0 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
COFKGGJM_00942 4.4e-247 obg S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
COFKGGJM_00943 4.9e-176 rnz 3.1.26.11 J Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
COFKGGJM_00944 1.6e-154 XK27_05435 1.1.1.100 S Belongs to the short-chain dehydrogenases reductases (SDR) family
COFKGGJM_00945 0.0 recJ L Single-stranded-DNA-specific exonuclease RecJ
COFKGGJM_00946 9.2e-92 apt 2.4.2.7 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
COFKGGJM_00947 4.3e-88
COFKGGJM_00949 1.8e-24
COFKGGJM_00950 0.0 G Peptidase_C39 like family
COFKGGJM_00951 0.0 2.7.7.6 M Peptidase family M23
COFKGGJM_00952 5.5e-118 rfbP 2.7.8.6 M Bacterial sugar transferase
COFKGGJM_00953 2.5e-172 yfdH 2.4.2.53 GT2 M Glycosyltransferase, group 2 family protein
COFKGGJM_00954 4.3e-146 cps1D M Domain of unknown function (DUF4422)
COFKGGJM_00955 1.2e-135 recX 2.4.1.337 GT4 S Regulatory protein RecX
COFKGGJM_00956 4.9e-31
COFKGGJM_00957 6.6e-34 S Protein of unknown function (DUF2922)
COFKGGJM_00958 2.6e-142 yihY S Belongs to the UPF0761 family
COFKGGJM_00959 9e-281 yjeM E Amino Acid
COFKGGJM_00960 8e-255 E Arginine ornithine antiporter
COFKGGJM_00961 1.3e-220 arcT 2.6.1.1 E Aminotransferase
COFKGGJM_00962 6.5e-167 map 3.4.11.18 E Methionine Aminopeptidase
COFKGGJM_00963 1.4e-78 fld C Flavodoxin
COFKGGJM_00964 1.3e-67 gtcA S Teichoic acid glycosylation protein
COFKGGJM_00965 7.5e-16
COFKGGJM_00966 3.8e-33
COFKGGJM_00967 9e-209 mnaA 5.1.3.14 G Belongs to the UDP-N-acetylglucosamine 2-epimerase family
COFKGGJM_00969 1.9e-231 yfmL L DEAD DEAH box helicase
COFKGGJM_00970 5.9e-191 mocA S Oxidoreductase
COFKGGJM_00971 9.1e-62 S Domain of unknown function (DUF4828)
COFKGGJM_00972 1.1e-104 yvdD 3.2.2.10 S Belongs to the LOG family
COFKGGJM_00973 1.5e-164 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
COFKGGJM_00974 1e-295 gshF 6.3.2.2 H Belongs to the glutamate--cysteine ligase type 1 family
COFKGGJM_00975 5.7e-194 S Protein of unknown function (DUF3114)
COFKGGJM_00976 1.6e-79 yjcF 3.5.4.33, 4.4.1.8 K protein acetylation
COFKGGJM_00977 9.3e-119 ybhL S Belongs to the BI1 family
COFKGGJM_00978 7e-75 yhjX P Major Facilitator Superfamily
COFKGGJM_00979 8.5e-12
COFKGGJM_00980 4.8e-93 K Acetyltransferase (GNAT) family
COFKGGJM_00981 8.6e-75 K LytTr DNA-binding domain
COFKGGJM_00982 1.3e-65 S Protein of unknown function (DUF3021)
COFKGGJM_00983 1.6e-155 3.2.1.96, 3.5.1.28 GH73 M N-acetylmuramoyl-L-alanine amidase
COFKGGJM_00984 1.2e-97 2.3.1.128 K acetyltransferase
COFKGGJM_00985 1.4e-192
COFKGGJM_00987 2.4e-36 L Transposase
COFKGGJM_00988 1.3e-120 L Transposase
COFKGGJM_00989 1.7e-133 K Transcriptional regulatory protein, C-terminal domain protein
COFKGGJM_00990 1.3e-159 pstS P Phosphate
COFKGGJM_00991 1.1e-153 pstC P probably responsible for the translocation of the substrate across the membrane
COFKGGJM_00992 5.9e-155 pstA P Phosphate transport system permease protein PstA
COFKGGJM_00993 3.1e-136 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
COFKGGJM_00994 6.6e-125 phoU P Plays a role in the regulation of phosphate uptake
COFKGGJM_00995 1.6e-144
COFKGGJM_00996 6.1e-140 ydaM M Glycosyl transferase
COFKGGJM_00997 5.7e-43 ydaM M Glycosyl transferase family group 2
COFKGGJM_00998 3.3e-219 G Glycosyl hydrolases family 8
COFKGGJM_00999 1.7e-139 nfrA 1.5.1.38, 1.5.1.39 C nitroreductase
COFKGGJM_01000 0.0 mycA 4.2.1.53 S Myosin-crossreactive antigen
COFKGGJM_01001 1.1e-237 ktrB P Potassium uptake protein
COFKGGJM_01002 1.2e-115 ktrA P domain protein
COFKGGJM_01003 6.4e-80 Q Methyltransferase
COFKGGJM_01004 1.1e-231 mntH P H( )-stimulated, divalent metal cation uptake system
COFKGGJM_01005 6.8e-178 hemH 4.99.1.1, 4.99.1.9 H Catalyzes the ferrous insertion into protoporphyrin IX
COFKGGJM_01006 5.1e-170 mccA 2.5.1.134, 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
COFKGGJM_01007 3.2e-95 S NADPH-dependent FMN reductase
COFKGGJM_01008 1.2e-178 MA20_14895 S Conserved hypothetical protein 698
COFKGGJM_01009 5.1e-133 I alpha/beta hydrolase fold
COFKGGJM_01010 1e-167 lsa S ABC transporter
COFKGGJM_01011 1.1e-180 yfeX P Peroxidase
COFKGGJM_01012 7.5e-275 arcD S C4-dicarboxylate anaerobic carrier
COFKGGJM_01013 1.1e-258 ytjP 3.5.1.18 E Dipeptidase
COFKGGJM_01014 1.3e-216 uhpT EGP Major facilitator Superfamily
COFKGGJM_01015 1.7e-284 gtfA 2.4.1.7 GH13 G Sucrose glucosyltransferase
COFKGGJM_01016 1.2e-130 ponA V Beta-lactamase enzyme family
COFKGGJM_01017 8.7e-229 dacA 3.4.16.4 M Belongs to the peptidase S11 family
COFKGGJM_01018 2.5e-74
COFKGGJM_01019 5.4e-200 galM 5.1.3.3 G Catalyzes the interconversion of alpha and beta anomers of maltose
COFKGGJM_01020 2.2e-21
COFKGGJM_01021 5.1e-262 S Uncharacterized protein conserved in bacteria (DUF2252)
COFKGGJM_01022 1.4e-161 L transposase, IS605 OrfB family
COFKGGJM_01023 1e-295 L PFAM plasmid pRiA4b ORF-3 family protein
COFKGGJM_01024 1.9e-205 adhA 1.1.1.1 C Zinc-binding alcohol dehydrogenase family protein
COFKGGJM_01025 6.6e-110 ppiB 5.2.1.8 G PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
COFKGGJM_01026 1.3e-157 mleR K LysR family
COFKGGJM_01027 2.2e-304 sfcA 1.1.1.38, 4.1.1.101 C Malic enzyme
COFKGGJM_01028 4e-259 fumC 4.2.1.2 C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
COFKGGJM_01029 1.2e-266 frdC 1.3.5.4 C FAD binding domain
COFKGGJM_01030 4.9e-252 yflS P Sodium:sulfate symporter transmembrane region
COFKGGJM_01031 3.9e-159 mleR K LysR family
COFKGGJM_01032 2.1e-252 yjjP S Putative threonine/serine exporter
COFKGGJM_01033 1e-116 ung2 3.2.2.27 L Uracil-DNA glycosylase
COFKGGJM_01034 3.2e-270 emrY EGP Major facilitator Superfamily
COFKGGJM_01035 2.2e-187 I Alpha beta
COFKGGJM_01036 2.2e-102 thiJ 2.7.11.1, 3.5.1.124 S DJ-1/PfpI family
COFKGGJM_01037 0.0 mprF 2.3.2.3 S Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
COFKGGJM_01039 4.3e-166 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 J Responsible for synthesis of pseudouridine from uracil
COFKGGJM_01040 1.9e-122 S Domain of unknown function (DUF4811)
COFKGGJM_01041 2.1e-269 lmrB EGP Major facilitator Superfamily
COFKGGJM_01042 3.1e-72 merR K MerR HTH family regulatory protein
COFKGGJM_01043 2.9e-57
COFKGGJM_01044 0.0 rnjA J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
COFKGGJM_01045 3.1e-220 S CAAX protease self-immunity
COFKGGJM_01046 3.6e-109 glnP P ABC transporter permease
COFKGGJM_01047 2.4e-110 gluC P ABC transporter permease
COFKGGJM_01048 3.3e-152 glnH ET ABC transporter
COFKGGJM_01049 1.4e-133 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
COFKGGJM_01050 5.5e-83 usp1 T Belongs to the universal stress protein A family
COFKGGJM_01051 4.2e-108 S VIT family
COFKGGJM_01052 2.5e-116 S membrane
COFKGGJM_01053 5.5e-164 czcD P cation diffusion facilitator family transporter
COFKGGJM_01054 1.6e-123 sirR K iron dependent repressor
COFKGGJM_01055 1e-30 cspC K Cold shock protein
COFKGGJM_01056 4.4e-127 thrE S Putative threonine/serine exporter
COFKGGJM_01057 1e-81 S Threonine/Serine exporter, ThrE
COFKGGJM_01058 1.5e-118 lssY 3.6.1.27 I phosphatase
COFKGGJM_01059 4.7e-08 2.3.1.128 J Acetyltransferase (GNAT) domain
COFKGGJM_01060 3.3e-275 lysP E amino acid
COFKGGJM_01061 9e-113 dak 2.7.1.74, 2.7.1.76 F deoxynucleoside kinase
COFKGGJM_01067 1.7e-97 epsB M biosynthesis protein
COFKGGJM_01068 3e-107 ywqD 2.7.10.1 D Capsular exopolysaccharide family
COFKGGJM_01069 2e-48 pglC M Bacterial sugar transferase
COFKGGJM_01070 1.2e-86 GT4 G Glycosyl transferase 4-like
COFKGGJM_01071 1.2e-68 sacB GT2,GT4 M Stealth protein CR2, conserved region 2
COFKGGJM_01072 1.6e-41 M cog cog1442
COFKGGJM_01074 5.7e-73 cps2I S Psort location CytoplasmicMembrane, score
COFKGGJM_01075 5.5e-29 M Glycosyltransferase sugar-binding region containing DXD motif
COFKGGJM_01076 2.1e-28 S Glycosyltransferase, group 2 family protein
COFKGGJM_01077 3.2e-29 S COG0463 Glycosyltransferases involved in cell wall biogenesis
COFKGGJM_01078 6.5e-50 S Glycosyltransferase, group 2 family protein
COFKGGJM_01080 1.5e-29 S Acyltransferase family
COFKGGJM_01081 0.0 gtfC 2.4.1.5 GH13 G Glycosyl hydrolase family 70
COFKGGJM_01082 4e-283 2.4.1.5 GH13 G Glycosyl hydrolase family 70
COFKGGJM_01083 7.1e-25
COFKGGJM_01084 5.9e-155
COFKGGJM_01085 4.8e-28
COFKGGJM_01086 4.4e-152 3.1.3.73 G Belongs to the phosphoglycerate mutase family
COFKGGJM_01087 5.2e-122 nagB 3.1.1.31, 3.5.99.6 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
COFKGGJM_01088 8.9e-104 fic D Fic/DOC family
COFKGGJM_01089 5.6e-71
COFKGGJM_01090 4.3e-223 XK27_00340 3.1.3.5 F Belongs to the 5'-nucleotidase family
COFKGGJM_01091 5.1e-63 XK27_00340 3.1.3.5 F Belongs to the 5'-nucleotidase family
COFKGGJM_01092 1.5e-22 L nuclease
COFKGGJM_01093 0.0 sbcC L Putative exonuclease SbcCD, C subunit
COFKGGJM_01094 8.7e-204 sbcD L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
COFKGGJM_01095 3.7e-145 ywqE 3.1.3.48 GM PHP domain protein
COFKGGJM_01096 0.0 snf 2.7.11.1 KL domain protein
COFKGGJM_01097 3e-07 D nuclear chromosome segregation
COFKGGJM_01099 3.2e-232 mmuP E amino acid
COFKGGJM_01100 3.6e-147 mmuM 1.5.1.20, 2.1.1.10 H homocysteine S-methyltransferase
COFKGGJM_01101 5.3e-51 S SEC-C Motif Domain Protein
COFKGGJM_01102 5.2e-32 T PemK-like, MazF-like toxin of type II toxin-antitoxin system
COFKGGJM_01103 1.5e-34
COFKGGJM_01104 5.9e-43 rihA F Inosine-uridine preferring nucleoside hydrolase
COFKGGJM_01105 1.4e-56
COFKGGJM_01106 0.0 L Type III restriction enzyme, res subunit
COFKGGJM_01107 2.6e-288 S Protein of unknown function DUF262
COFKGGJM_01109 2.2e-82 EGP Sugar (and other) transporter
COFKGGJM_01110 5.1e-173 S Domain of unknown function (DUF389)
COFKGGJM_01111 7.7e-79
COFKGGJM_01112 0.0 cadA 3.6.3.3, 3.6.3.5 P E1-E2 ATPase
COFKGGJM_01113 7.9e-35 copZ C Heavy-metal-associated domain
COFKGGJM_01114 3.6e-94 dps P Belongs to the Dps family
COFKGGJM_01115 5.2e-113 rcfA 4.1.99.16, 4.2.3.22, 4.2.3.75 K Transcriptional regulator, Crp Fnr family
COFKGGJM_01116 6.3e-113 ung2 3.2.2.27 L Uracil-DNA glycosylase
COFKGGJM_01118 1.4e-44 5.1.1.13 M Asp/Glu/Hydantoin racemase
COFKGGJM_01119 8.3e-21 5.1.1.13 M Asp/Glu/Hydantoin racemase
COFKGGJM_01120 3e-162 L Recombinase
COFKGGJM_01121 2.4e-110 L Recombinase zinc beta ribbon domain
COFKGGJM_01122 1.5e-69 L Recombinase zinc beta ribbon domain
COFKGGJM_01123 6.3e-19
COFKGGJM_01124 4.2e-55 S Bacteriophage holin family
COFKGGJM_01125 6.5e-55 S Phage head-tail joining protein
COFKGGJM_01126 1.5e-40 S Phage gp6-like head-tail connector protein
COFKGGJM_01127 5.7e-158 S Phage capsid family
COFKGGJM_01128 4.5e-88 tpx 1.11.1.15 O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
COFKGGJM_01129 1.4e-127 3.6.1.13, 3.6.1.55 F NUDIX domain
COFKGGJM_01130 1e-257 pncB 6.3.4.21 F Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
COFKGGJM_01131 1.2e-102 pncA Q Isochorismatase family
COFKGGJM_01132 6.2e-140 tcyA ET Belongs to the bacterial solute-binding protein 3 family
COFKGGJM_01133 8.3e-134 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
COFKGGJM_01134 1.4e-119 tcyB E ABC transporter
COFKGGJM_01135 3.2e-214 metC 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
COFKGGJM_01136 1.7e-167 I alpha/beta hydrolase fold
COFKGGJM_01137 3e-133 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
COFKGGJM_01138 0.0 S Bacterial membrane protein, YfhO
COFKGGJM_01139 2.9e-184 lacM 3.2.1.23, 3.2.1.35, 3.2.1.51, 3.2.1.97 GH101,GH29 G beta-galactosidase
COFKGGJM_01140 0.0 lacL 3.2.1.23 G Belongs to the glycosyl hydrolase 2 family
COFKGGJM_01141 3.1e-245 L Transposase
COFKGGJM_01143 8.1e-84 ydcK S Belongs to the SprT family
COFKGGJM_01144 0.0 yhgF K Tex-like protein N-terminal domain protein
COFKGGJM_01145 3.7e-151 nadE 6.3.1.5 F Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
COFKGGJM_01146 1.5e-285 pncB 6.3.4.21 F Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
COFKGGJM_01147 1.8e-127 gntR1 K UbiC transcription regulator-associated domain protein
COFKGGJM_01148 8.2e-131 racD 5.1.1.13 M Belongs to the aspartate glutamate racemases family
COFKGGJM_01149 1.9e-303 aspT P Predicted Permease Membrane Region
COFKGGJM_01150 8.5e-249 EGP Major facilitator Superfamily
COFKGGJM_01151 5.2e-53 ywiB S Domain of unknown function (DUF1934)
COFKGGJM_01152 8.7e-51 rpoE K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
COFKGGJM_01153 0.0 pyrG 6.3.4.2 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
COFKGGJM_01154 2e-236 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
COFKGGJM_01155 4.6e-41 rpmE2 J Ribosomal protein L31
COFKGGJM_01156 7.7e-236 pts13C G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
COFKGGJM_01157 3.1e-164 S Alpha/beta hydrolase of unknown function (DUF915)
COFKGGJM_01158 7.3e-116 srtA 3.4.22.70 M sortase family
COFKGGJM_01159 0.0 ppsA 2.7.9.2 H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate
COFKGGJM_01160 4.2e-160 3.2.1.55 GH51 G Right handed beta helix region
COFKGGJM_01161 9.8e-138 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
COFKGGJM_01162 1.3e-162 fba 4.1.2.13, 4.1.2.29 G Fructose-1,6-bisphosphate aldolase, class II
COFKGGJM_01163 9.2e-121 pgm3 3.1.3.73 G Belongs to the phosphoglycerate mutase family
COFKGGJM_01164 8e-87 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
COFKGGJM_01165 2e-92 lemA S LemA family
COFKGGJM_01166 2e-158 htpX O Belongs to the peptidase M48B family
COFKGGJM_01167 1.9e-256 murF 6.3.2.10 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
COFKGGJM_01168 3.6e-253 cshA 3.6.4.13 F DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
COFKGGJM_01169 3.1e-95 yqeG S HAD phosphatase, family IIIA
COFKGGJM_01170 2.1e-218 yqeH S Ribosome biogenesis GTPase YqeH
COFKGGJM_01171 1.9e-47 yhbY J RNA-binding protein
COFKGGJM_01172 6.9e-121 nadD 2.7.7.18, 3.6.1.55 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
COFKGGJM_01173 2.8e-111 nadD 2.7.6.3, 2.7.7.18 H Hydrolase, HD family
COFKGGJM_01174 4.9e-60 rsfS J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
COFKGGJM_01175 9.7e-135 yqeM Q Methyltransferase
COFKGGJM_01176 1.4e-209 ylbM S Belongs to the UPF0348 family
COFKGGJM_01177 2.9e-99 yceD S Uncharacterized ACR, COG1399
COFKGGJM_01178 1.1e-28 rpmF J Belongs to the bacterial ribosomal protein bL32 family
COFKGGJM_01179 1.5e-121 K response regulator
COFKGGJM_01180 3.7e-279 arlS 2.7.13.3 T Histidine kinase
COFKGGJM_01181 4.8e-266 yjeM E Amino Acid
COFKGGJM_01182 7.3e-234 V MatE
COFKGGJM_01183 5.6e-68 def_1 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins
COFKGGJM_01184 5e-168 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
COFKGGJM_01185 1.6e-42 acyP 3.6.1.7 C Belongs to the acylphosphatase family
COFKGGJM_01186 4.8e-145 spoU 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
COFKGGJM_01187 5.3e-92 XK27_09705 6.1.1.14 S Metal dependent phosphohydrolases with conserved 'HD' motif.
COFKGGJM_01188 6.7e-59 yodB K Transcriptional regulator, HxlR family
COFKGGJM_01189 2.3e-198 pheS 6.1.1.20 J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
COFKGGJM_01190 0.0 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
COFKGGJM_01191 1.6e-55 patA 2.6.1.1, 2.6.1.57 E Aminotransferase
COFKGGJM_01192 4.5e-296 gltX 6.1.1.17, 6.1.1.24 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
COFKGGJM_01193 6.2e-265 glnA 6.3.1.2 E glutamine synthetase
COFKGGJM_01194 4.5e-174 miaA 2.5.1.75 F Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
COFKGGJM_01195 5.9e-22 S Protein of unknown function (DUF3042)
COFKGGJM_01196 3.4e-67 yqhL P Rhodanese-like protein
COFKGGJM_01197 5.6e-183 glk 2.7.1.2 G Glucokinase
COFKGGJM_01198 2.2e-35 yqgQ S Bacterial protein of unknown function (DUF910)
COFKGGJM_01199 4e-108 gluP 3.4.21.105 S Peptidase, S54 family
COFKGGJM_01200 6.8e-101 ygfA 6.3.3.2 H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
COFKGGJM_01201 4.2e-21 rpmG J Belongs to the bacterial ribosomal protein bL33 family
COFKGGJM_01202 0.0 pbp2b 3.4.16.4 M Penicillin-binding Protein
COFKGGJM_01203 0.0 S membrane
COFKGGJM_01204 3.1e-68 yneR S Belongs to the HesB IscA family
COFKGGJM_01205 5.3e-78 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
COFKGGJM_01206 8e-117 udk 2.7.1.48 F Cytidine monophosphokinase
COFKGGJM_01207 4.7e-114 rlpA M PFAM NLP P60 protein
COFKGGJM_01208 0.0 helD 3.6.4.12 L DNA helicase
COFKGGJM_01209 2.8e-36 Q pyridine nucleotide-disulphide oxidoreductase
COFKGGJM_01210 6.2e-157 EG EamA-like transporter family
COFKGGJM_01211 0.0 ltaS 2.7.8.20 M Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
COFKGGJM_01212 1.7e-176 coaA 2.7.1.33 F Pantothenic acid kinase
COFKGGJM_01213 1.3e-218 S cog cog1373
COFKGGJM_01215 3.6e-301 guaA 2.3.1.128, 6.3.5.2 F Catalyzes the synthesis of GMP from XMP
COFKGGJM_01216 1.5e-156 L Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
COFKGGJM_01218 2.9e-65 S Cell surface protein
COFKGGJM_01220 8e-182 iunH2 3.2.2.1 F nucleoside hydrolase
COFKGGJM_01221 9.8e-183 yumC 1.18.1.2, 1.19.1.1, 1.8.1.9 C Ferredoxin--NADP reductase
COFKGGJM_01222 1.3e-34 3.6.4.12 S PD-(D/E)XK nuclease family transposase
COFKGGJM_01223 7e-46 3.6.4.12 S PD-(D/E)XK nuclease family transposase
COFKGGJM_01224 1.8e-36 3.6.4.12 S PD-(D/E)XK nuclease family transposase
COFKGGJM_01225 1.3e-114 gph 3.1.3.18 S HAD hydrolase, family IA, variant
COFKGGJM_01226 2.2e-177 yagE E amino acid
COFKGGJM_01227 4.6e-52 yagE E amino acid
COFKGGJM_01228 3.4e-85 dps P Belongs to the Dps family
COFKGGJM_01229 0.0 pacL 3.6.3.8 P P-type ATPase
COFKGGJM_01230 1.5e-177 pip 3.4.11.5 E Releases the N-terminal proline from various substrates
COFKGGJM_01231 0.0 pepX 3.4.14.11 E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline
COFKGGJM_01232 8.1e-79 L An automated process has identified a potential problem with this gene model
COFKGGJM_01233 7.9e-145 L PFAM Integrase catalytic region
COFKGGJM_01234 7.1e-25 K Helix-turn-helix domain
COFKGGJM_01235 1e-33 S Phage derived protein Gp49-like (DUF891)
COFKGGJM_01236 1.3e-60 L Resolvase, N terminal domain
COFKGGJM_01240 1.4e-140 D CobQ CobB MinD ParA nucleotide binding domain protein
COFKGGJM_01241 2.3e-28
COFKGGJM_01243 3e-165 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
COFKGGJM_01244 6e-195 aadAT EK Aminotransferase, class I
COFKGGJM_01245 3.4e-151 ansA 3.5.1.1 EJ L-asparaginase, type I
COFKGGJM_01246 1.8e-77 L Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
COFKGGJM_01247 7.9e-145 L PFAM Integrase catalytic region
COFKGGJM_01252 1.8e-113 frnE Q DSBA-like thioredoxin domain
COFKGGJM_01253 2.3e-164 I alpha/beta hydrolase fold
COFKGGJM_01254 5e-20 K Helix-turn-helix XRE-family like proteins
COFKGGJM_01255 3.3e-35 S Phage derived protein Gp49-like (DUF891)
COFKGGJM_01256 8e-202 3.5.1.104 M hydrolase, family 25
COFKGGJM_01257 2.6e-55 S Bacteriophage holin of superfamily 6 (Holin_LLH)
COFKGGJM_01258 5.8e-36 S Bacteriophage holin family
COFKGGJM_01261 5.5e-110 cotH M CotH kinase protein
COFKGGJM_01264 2.5e-259 3.4.24.40 M Peptidase family M23
COFKGGJM_01265 9.2e-158 S Phage tail protein
COFKGGJM_01266 0.0 M Phage tail tape measure protein TP901
COFKGGJM_01267 1.5e-19
COFKGGJM_01268 1.6e-23
COFKGGJM_01269 9.4e-115
COFKGGJM_01270 2.6e-76
COFKGGJM_01271 7.2e-62 S Bacteriophage HK97-gp10, putative tail-component
COFKGGJM_01272 6.6e-40 S Phage head-tail joining protein
COFKGGJM_01273 3.7e-67 S Phage gp6-like head-tail connector protein
COFKGGJM_01274 3.5e-208 S Phage capsid family
COFKGGJM_01275 3.7e-114 pi136 S Caudovirus prohead serine protease
COFKGGJM_01276 3.8e-240 S Phage portal protein
COFKGGJM_01280 0.0 terL S overlaps another CDS with the same product name
COFKGGJM_01281 1.3e-76 terS L Phage terminase, small subunit
COFKGGJM_01282 1.8e-147 L HNH nucleases
COFKGGJM_01283 1.2e-08
COFKGGJM_01285 1.6e-82 arpU S Phage transcriptional regulator, ArpU family
COFKGGJM_01290 3.6e-69 XK27_00160 S Domain of unknown function (DUF5052)
COFKGGJM_01294 3e-17
COFKGGJM_01296 8.5e-131
COFKGGJM_01298 7.6e-68
COFKGGJM_01300 1.9e-108 L DnaD domain protein
COFKGGJM_01303 1.7e-19
COFKGGJM_01304 3.1e-16 K Cro/C1-type HTH DNA-binding domain
COFKGGJM_01305 2.6e-22 S Uncharacterized protein conserved in bacteria (DUF2188)
COFKGGJM_01308 1.7e-12 S BIO14.03 Phage related functions and prophages. 98 identical to Orf10 of bacteriophage Tuc2009
COFKGGJM_01312 5e-18 S Protein of unknown function (DUF739)
COFKGGJM_01313 2e-50 S protein disulfide oxidoreductase activity
COFKGGJM_01314 8.4e-10
COFKGGJM_01316 1.1e-18
COFKGGJM_01318 7e-45
COFKGGJM_01321 2.2e-18
COFKGGJM_01323 9.2e-142 L Belongs to the 'phage' integrase family
COFKGGJM_01325 8.9e-41 yrvD S Pfam:DUF1049
COFKGGJM_01326 2.4e-150 3.1.3.102, 3.1.3.104 S hydrolase
COFKGGJM_01327 1.1e-89 ntd 2.4.2.6 F Nucleoside
COFKGGJM_01328 2e-18
COFKGGJM_01329 2.9e-159 S Alpha/beta hydrolase of unknown function (DUF915)
COFKGGJM_01330 4.7e-114 yviA S Protein of unknown function (DUF421)
COFKGGJM_01331 7e-72 S Protein of unknown function (DUF3290)
COFKGGJM_01332 5.6e-40 ybaN S Protein of unknown function (DUF454)
COFKGGJM_01333 0.0 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
COFKGGJM_01334 7.2e-158 endA V DNA/RNA non-specific endonuclease
COFKGGJM_01335 8.7e-254 yifK E Amino acid permease
COFKGGJM_01337 0.0 dxs 2.2.1.7 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
COFKGGJM_01338 2.3e-229 N Uncharacterized conserved protein (DUF2075)
COFKGGJM_01339 5.1e-122 S SNARE associated Golgi protein
COFKGGJM_01340 0.0 uvrA3 L excinuclease ABC, A subunit
COFKGGJM_01341 4.5e-55 crcB U Important for reducing fluoride concentration in the cell, thus reducing its toxicity
COFKGGJM_01342 2e-56 crcB D Important for reducing fluoride concentration in the cell, thus reducing its toxicity
COFKGGJM_01343 4.1e-68 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
COFKGGJM_01344 1.9e-144 S DUF218 domain
COFKGGJM_01345 0.0 ubiB S ABC1 family
COFKGGJM_01346 2.5e-245 yhdP S Transporter associated domain
COFKGGJM_01347 5e-75 copY K Copper transport repressor CopY TcrY
COFKGGJM_01348 6.9e-243 EGP Major facilitator Superfamily
COFKGGJM_01349 1.7e-73 yeaL S UPF0756 membrane protein
COFKGGJM_01350 1.2e-77 yphH S Cupin domain
COFKGGJM_01351 2.6e-77 C Flavodoxin
COFKGGJM_01352 3e-159 K LysR substrate binding domain protein
COFKGGJM_01353 1.7e-170 1.1.1.346 C Aldo keto reductase
COFKGGJM_01354 1.4e-38 gcvR T Belongs to the UPF0237 family
COFKGGJM_01355 3.9e-243 XK27_08635 S UPF0210 protein
COFKGGJM_01356 2.4e-95 K Acetyltransferase (GNAT) domain
COFKGGJM_01357 5.3e-153 S Alpha beta hydrolase
COFKGGJM_01358 6e-157 gspA M family 8
COFKGGJM_01359 4.3e-118 ypgQ S Metal dependent phosphohydrolases with conserved 'HD' motif.
COFKGGJM_01360 3e-90
COFKGGJM_01361 5.5e-161 degV S EDD domain protein, DegV family
COFKGGJM_01362 4.3e-266 pepC 3.4.22.40 E Peptidase C1-like family
COFKGGJM_01363 1.3e-125 rpiA 2.7.1.12, 5.3.1.6 G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
COFKGGJM_01364 1.9e-49 HA62_12640 S GCN5-related N-acetyl-transferase
COFKGGJM_01365 2.3e-101 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F dUTP diphosphatase
COFKGGJM_01366 1.5e-253 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
COFKGGJM_01367 4.7e-205 yacL S domain protein
COFKGGJM_01368 7.9e-271 cysS 6.1.1.16, 6.3.1.13 J Belongs to the class-I aminoacyl-tRNA synthetase family
COFKGGJM_01369 2.1e-70 mrnC J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
COFKGGJM_01370 4.7e-137 rlmB 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
COFKGGJM_01371 1.4e-21 rpmG J Belongs to the bacterial ribosomal protein bL33 family
COFKGGJM_01372 1.4e-15 secE U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
COFKGGJM_01373 3.4e-97 nusG K Participates in transcription elongation, termination and antitermination
COFKGGJM_01374 2.4e-69 rplK J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
COFKGGJM_01375 3e-122 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
COFKGGJM_01376 1.6e-224 aadAT EK Aminotransferase, class I
COFKGGJM_01378 7.2e-283 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
COFKGGJM_01379 2e-103 wecD3 K PFAM GCN5-related N-acetyltransferase
COFKGGJM_01381 0.0 clpL O associated with various cellular activities
COFKGGJM_01382 7.8e-32
COFKGGJM_01383 1.2e-214 patA 2.6.1.1 E Aminotransferase
COFKGGJM_01384 3.2e-173 ldhD 1.1.1.28 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
COFKGGJM_01385 5e-75 osmC O OsmC-like protein
COFKGGJM_01386 3.6e-260 S Putative peptidoglycan binding domain
COFKGGJM_01387 3.9e-108 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX
COFKGGJM_01388 1.6e-67
COFKGGJM_01389 5.2e-245 hisS 6.1.1.21 J histidyl-tRNA synthetase
COFKGGJM_01390 4e-215 yttB EGP Major facilitator Superfamily
COFKGGJM_01391 8.2e-103
COFKGGJM_01392 3.9e-24
COFKGGJM_01393 1.8e-173 scrR K Transcriptional regulator, LacI family
COFKGGJM_01394 4.2e-234 acm2 3.2.1.17 NU Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
COFKGGJM_01395 5.7e-90 L Integrase
COFKGGJM_01397 0.0 LV site-specific DNA-methyltransferase (adenine-specific) activity
COFKGGJM_01399 5.3e-10
COFKGGJM_01400 2e-61 soj D AAA domain
COFKGGJM_01402 4.5e-20 S Psort location Cytoplasmic, score 8.87
COFKGGJM_01407 4.3e-130 fabI 1.3.1.10, 1.3.1.9 I Enoyl- acyl-carrier-protein reductase NADH
COFKGGJM_01408 9.2e-136 accA 2.1.3.15, 6.4.1.2 I alpha subunit
COFKGGJM_01409 8.4e-143 accD 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
COFKGGJM_01410 1.6e-255 accC 6.3.4.14, 6.4.1.2 I Acetyl-CoA carboxylase biotin carboxylase subunit
COFKGGJM_01411 8.6e-75 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
COFKGGJM_01412 7.6e-74 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
COFKGGJM_01413 5.9e-222 fabF 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
COFKGGJM_01414 1.3e-126 IQ reductase
COFKGGJM_01415 3.1e-154 fabD 2.3.1.39 I Malonyl CoA-acyl carrier protein transacylase
COFKGGJM_01416 5e-32 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
COFKGGJM_01417 2.2e-171 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
COFKGGJM_01418 1.2e-76 marR K Transcriptional regulator, MarR family
COFKGGJM_01419 8e-70 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
COFKGGJM_01420 2e-220 V domain protein
COFKGGJM_01421 7.8e-94 K Transcriptional regulator (TetR family)
COFKGGJM_01422 3.4e-39 pspC KT positive regulation of macromolecule biosynthetic process
COFKGGJM_01423 1e-148
COFKGGJM_01424 3.1e-17 3.2.1.14 GH18
COFKGGJM_01425 2.1e-81 zur P Belongs to the Fur family
COFKGGJM_01426 1.5e-98 gmk2 2.7.4.8 F Guanylate kinase
COFKGGJM_01427 6.9e-74 apfA 2.7.7.72, 3.6.1.61 F Nudix hydrolase
COFKGGJM_01428 1.8e-254 yfnA E Amino Acid
COFKGGJM_01429 5.7e-231 EGP Sugar (and other) transporter
COFKGGJM_01430 2.4e-192 V Beta-lactamase
COFKGGJM_01431 1.6e-94 hpt 2.4.2.8 F Belongs to the purine pyrimidine phosphoribosyltransferase family
COFKGGJM_01432 9.2e-104 yhiD S MgtC family
COFKGGJM_01433 3.5e-117 S GyrI-like small molecule binding domain
COFKGGJM_01435 2.8e-109 S Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)
COFKGGJM_01436 3.2e-50 azlD E Branched-chain amino acid transport
COFKGGJM_01437 4.1e-119 azlC E azaleucine resistance protein AzlC
COFKGGJM_01438 1.7e-257 K Aminotransferase class I and II
COFKGGJM_01439 1e-218 S amidohydrolase
COFKGGJM_01440 8.5e-106 L hmm pf00665
COFKGGJM_01441 8.6e-137 thiM 2.7.1.50 H Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
COFKGGJM_01442 1.1e-147 thiD 2.5.1.3, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Phosphomethylpyrimidine kinase
COFKGGJM_01443 1.3e-114 thiE 2.5.1.3 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
COFKGGJM_01444 1.8e-226 clcA_2 P Chloride transporter, ClC family
COFKGGJM_01445 1.4e-34 L PFAM transposase IS116 IS110 IS902
COFKGGJM_01446 1.6e-67 L PFAM transposase IS116 IS110 IS902
COFKGGJM_01447 0.0 malZ 3.2.1.20 GH31 G Belongs to the glycosyl hydrolase 31 family
COFKGGJM_01448 4.2e-110 lssY 3.6.1.27 I Acid phosphatase homologues
COFKGGJM_01449 4.3e-08 L Transposase IS66 family
COFKGGJM_01452 5e-13
COFKGGJM_01453 8.6e-08
COFKGGJM_01454 3.6e-126 L Belongs to the 'phage' integrase family
COFKGGJM_01456 8.8e-76 traP 1.14.99.57, 6.2.1.3 S enzyme involved in biosynthesis of extracellular polysaccharides
COFKGGJM_01457 2.7e-67 spxA 1.20.4.1 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
COFKGGJM_01458 6.7e-119 mecA NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
COFKGGJM_01459 7.5e-194 coiA 3.6.4.12 S Competence protein
COFKGGJM_01460 4.5e-263 pipD E Dipeptidase
COFKGGJM_01461 3.1e-113 yjbH Q Thioredoxin
COFKGGJM_01462 2.3e-111 yjbM 2.7.6.5 S RelA SpoT domain protein
COFKGGJM_01463 8.6e-153 nadK 2.7.1.23 F Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
COFKGGJM_01464 1.6e-171 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 G Responsible for synthesis of pseudouridine from uracil
COFKGGJM_01465 4.3e-172 arcC 2.7.2.2 E Belongs to the carbamate kinase family
COFKGGJM_01466 7.6e-191 argF 2.1.3.3 E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
COFKGGJM_01467 3.6e-154 KT YcbB domain
COFKGGJM_01468 3.1e-30 xylB 2.7.1.12, 2.7.1.17 G Belongs to the FGGY kinase family
COFKGGJM_01470 1e-25
COFKGGJM_01471 5e-262 pgi 5.3.1.9 G Belongs to the GPI family
COFKGGJM_01472 9.6e-96 lacA 2.3.1.79 S Transferase hexapeptide repeat
COFKGGJM_01473 4.1e-153 glcU U sugar transport
COFKGGJM_01474 7.6e-272 yclK 2.7.13.3 T Histidine kinase
COFKGGJM_01475 1.2e-134 K response regulator
COFKGGJM_01477 1.3e-76 lytE M Lysin motif
COFKGGJM_01478 1.1e-147 XK27_02985 S Cof-like hydrolase
COFKGGJM_01479 1.8e-78 K Transcriptional regulator
COFKGGJM_01480 0.0 oatA I Acyltransferase
COFKGGJM_01481 5.6e-52
COFKGGJM_01482 0.0 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
COFKGGJM_01483 8.5e-254 glmM 5.4.2.10 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
COFKGGJM_01484 1.3e-125 ybbR S YbbR-like protein
COFKGGJM_01485 5e-151 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
COFKGGJM_01486 3.7e-249 fucP G Major Facilitator Superfamily
COFKGGJM_01487 5.1e-66 rbsD 5.4.99.62 G Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose
COFKGGJM_01488 6.1e-163 rbsK 2.7.1.15 H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
COFKGGJM_01489 3e-167 murB 1.3.1.98 M Cell wall formation
COFKGGJM_01490 2.7e-102 dnaQ 2.7.7.7 L DNA polymerase III
COFKGGJM_01491 4.4e-76 S PAS domain
COFKGGJM_01492 8.8e-87 K Acetyltransferase (GNAT) domain
COFKGGJM_01493 2e-80 ydiB 2.7.1.221, 5.1.1.1 O Hydrolase, P-loop family
COFKGGJM_01494 3.2e-178 pta 2.3.1.8, 3.6.3.21 C phosphate acetyltransferase
COFKGGJM_01495 9e-135 ung 3.2.2.27 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
COFKGGJM_01496 6.3e-105 yxjI
COFKGGJM_01497 1.4e-83 smpB J the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
COFKGGJM_01498 0.0 rnr J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
COFKGGJM_01499 5.9e-143 est 3.1.1.1 S Serine aminopeptidase, S33
COFKGGJM_01500 1.8e-34 secG U Preprotein translocase
COFKGGJM_01501 2.4e-292 clcA P chloride
COFKGGJM_01502 1.2e-244 yifK E Amino acid permease
COFKGGJM_01503 4.2e-250 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
COFKGGJM_01504 1.8e-141 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
COFKGGJM_01505 1.2e-227 pgk 2.7.2.3, 5.3.1.1 F Belongs to the phosphoglycerate kinase family
COFKGGJM_01506 1.1e-189 gap 1.2.1.12 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
COFKGGJM_01508 2.1e-103 clpP 3.4.21.92 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
COFKGGJM_01509 2.4e-131 glpT G Major Facilitator Superfamily
COFKGGJM_01510 1.5e-71 glpT G Major Facilitator Superfamily
COFKGGJM_01511 8.8e-15
COFKGGJM_01513 1.5e-169 whiA K May be required for sporulation
COFKGGJM_01514 2.1e-185 ybhK S Required for morphogenesis under gluconeogenic growth conditions
COFKGGJM_01515 4.9e-162 rapZ S Displays ATPase and GTPase activities
COFKGGJM_01516 5.4e-245 steT E amino acid
COFKGGJM_01517 0.0 uvrA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
COFKGGJM_01518 0.0 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
COFKGGJM_01519 9.1e-14
COFKGGJM_01520 1.5e-115 yfbR S HD containing hydrolase-like enzyme
COFKGGJM_01521 6.9e-153 L Transposase
COFKGGJM_01522 7.4e-67 L Transposase
COFKGGJM_01523 0.0 pgm 5.4.2.2, 5.4.2.8 G Phosphoglucomutase phosphomannomutase, alpha beta alpha domain
COFKGGJM_01524 7.2e-89 ykhA 3.1.2.20 I Thioesterase superfamily
COFKGGJM_01525 2.9e-162 aatB ET PFAM extracellular solute-binding protein, family 3
COFKGGJM_01526 1.8e-204 argE 3.5.1.18 E succinyl-diaminopimelate desuccinylase
COFKGGJM_01527 8.6e-173 trxB 1.8.1.9 C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
COFKGGJM_01528 2.7e-168 lutA C Cysteine-rich domain
COFKGGJM_01529 1.3e-292 lutB C 4Fe-4S dicluster domain
COFKGGJM_01530 1.5e-135 yrjD S LUD domain
COFKGGJM_01531 1.1e-169 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
COFKGGJM_01532 8.5e-182 gpsA 1.1.1.94 I Glycerol-3-phosphate dehydrogenase
COFKGGJM_01533 3.2e-155 lgt 2.1.1.199 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
COFKGGJM_01534 1.7e-176 hprK F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
COFKGGJM_01535 4.9e-52 yvlD S Mycobacterial 4 TMS phage holin, superfamily IV
COFKGGJM_01536 7.7e-31 KT PspC domain protein
COFKGGJM_01537 6.6e-187 prfB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
COFKGGJM_01538 0.0 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
COFKGGJM_01539 4.5e-97 hpf J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
COFKGGJM_01540 1.1e-93 comFC S Competence protein
COFKGGJM_01541 9.5e-250 comFA L Helicase C-terminal domain protein
COFKGGJM_01542 4.3e-107 yvyE 3.4.13.9 S YigZ family
COFKGGJM_01543 2.2e-113 glf 5.4.99.9 M UDP-galactopyranose mutase
COFKGGJM_01544 1.8e-209 rfbX S Membrane protein involved in the export of O-antigen and teichoic acid
COFKGGJM_01545 4.7e-76 M transferase activity, transferring glycosyl groups
COFKGGJM_01546 7.7e-89 cps3F
COFKGGJM_01547 3.9e-28 M biosynthesis protein
COFKGGJM_01548 9.9e-76 rgpB GT2 M Glycosyl transferase family 2
COFKGGJM_01549 1.4e-67 S Glycosyltransferase like family
COFKGGJM_01550 2e-81 glfT1 1.1.1.133 S Glycosyltransferase like family 2
COFKGGJM_01551 1.2e-33 S Acyltransferase family
COFKGGJM_01552 1.5e-70 rnhA 3.1.26.4 L Ribonuclease HI
COFKGGJM_01553 5.6e-65 esbA S Family of unknown function (DUF5322)
COFKGGJM_01554 2.4e-72 lspA 3.4.23.36 MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins
COFKGGJM_01555 2.2e-173 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
COFKGGJM_01556 1.4e-206 carA 6.3.5.5 F Belongs to the CarA family
COFKGGJM_01557 0.0 carB 6.3.5.5 F Carbamoyl-phosphate synthase
COFKGGJM_01558 0.0 FbpA K Fibronectin-binding protein
COFKGGJM_01559 8.8e-95 glf 5.4.99.9 M UDP-galactopyranose mutase
COFKGGJM_01560 6.2e-154 rfbX S Membrane protein involved in the export of O-antigen and teichoic acid
COFKGGJM_01561 4.5e-66 M Glycosyltransferase group 2 family protein
COFKGGJM_01562 3.2e-104 G Glycosyltransferase Family 4
COFKGGJM_01563 5.2e-52 2.3.1.79 S Hexapeptide repeat of succinyl-transferase
COFKGGJM_01564 1.9e-155 rfbD 1.1.1.133, 5.1.3.13 M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
COFKGGJM_01565 2.9e-51 sidG D nuclear chromosome segregation
COFKGGJM_01566 4.2e-153 EG EamA-like transporter family
COFKGGJM_01567 9.4e-118 L Integrase
COFKGGJM_01568 3e-156 rssA S Phospholipase, patatin family
COFKGGJM_01569 4.1e-89 sacB 2.4.1.10, 2.4.1.9, 3.2.1.26 GH32,GH68 M Levansucrase/Invertase
COFKGGJM_01570 4.4e-91 sacB 2.4.1.10, 2.4.1.9, 3.2.1.26 GH32,GH68 M Levansucrase/Invertase
COFKGGJM_01571 1.8e-198 xerS L Belongs to the 'phage' integrase family
COFKGGJM_01574 6.2e-260 ltrA_1 2.7.7.49 L PFAM RNA-directed DNA polymerase (Reverse transcriptase)
COFKGGJM_01575 1.6e-155 S Hydrolases of the alpha beta superfamily
COFKGGJM_01576 2.1e-196 adhP 1.1.1.1 C alcohol dehydrogenase
COFKGGJM_01577 4.4e-77 ctsR K Belongs to the CtsR family
COFKGGJM_01578 0.0 clpC O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
COFKGGJM_01579 3e-110 K Bacterial regulatory proteins, tetR family
COFKGGJM_01583 3.4e-18
COFKGGJM_01584 6.2e-123 L Belongs to the 'phage' integrase family
COFKGGJM_01585 1.8e-23 patA 2.6.1.1, 2.6.1.57 E Aminotransferase
COFKGGJM_01586 1e-31 patA 2.6.1.1, 2.6.1.57 E Aminotransferase
COFKGGJM_01587 6.1e-42 patA 2.6.1.1, 2.6.1.57 E Aminotransferase
COFKGGJM_01588 3.9e-12
COFKGGJM_01589 2.3e-98 msrA 1.8.4.11, 1.8.4.12 C Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
COFKGGJM_01590 4.8e-51 S Iron-sulfur cluster assembly protein
COFKGGJM_01591 9.7e-150
COFKGGJM_01592 3e-179
COFKGGJM_01593 8.2e-85 dut S Protein conserved in bacteria
COFKGGJM_01597 6.4e-111 K Transcriptional regulator
COFKGGJM_01598 3.4e-114 M Lysin motif
COFKGGJM_01599 2.1e-79
COFKGGJM_01600 3.1e-28 wecD3 K PFAM GCN5-related N-acetyltransferase
COFKGGJM_01601 7e-56 wecD3 K PFAM GCN5-related N-acetyltransferase
COFKGGJM_01602 5.9e-96 ltrA S Bacterial low temperature requirement A protein (LtrA)
COFKGGJM_01603 1.1e-204 cytX U Belongs to the purine-cytosine permease (2.A.39) family
COFKGGJM_01604 4.3e-13
COFKGGJM_01605 4.2e-82 L PFAM Integrase catalytic region
COFKGGJM_01606 1.3e-224 oxlT P Major Facilitator Superfamily
COFKGGJM_01607 2.1e-160 spoU 2.1.1.185 J Methyltransferase
COFKGGJM_01608 1.2e-95 ywlG S Belongs to the UPF0340 family
COFKGGJM_01609 4.6e-49 S ParE toxin of type II toxin-antitoxin system, parDE
COFKGGJM_01610 1e-37 D Antitoxin component of a toxin-antitoxin (TA) module
COFKGGJM_01611 1.8e-196 EGP Major facilitator Superfamily
COFKGGJM_01612 8.4e-207 gldA 1.1.1.6 C dehydrogenase
COFKGGJM_01613 0.0 ltaS 2.7.8.20 M Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
COFKGGJM_01614 1.2e-39
COFKGGJM_01615 8e-125 pgm3 3.1.3.73 G phosphoglycerate mutase family
COFKGGJM_01617 2.8e-20 K Bacterial transcriptional regulator
COFKGGJM_01618 1.3e-70 IQ Enoyl-(Acyl carrier protein) reductase
COFKGGJM_01619 6.7e-67 S C4-dicarboxylate anaerobic carrier
COFKGGJM_01620 2.5e-184 S C4-dicarboxylate anaerobic carrier
COFKGGJM_01621 2.7e-250 nhaC C Na H antiporter NhaC
COFKGGJM_01622 1.4e-240 pbuX F xanthine permease
COFKGGJM_01623 4.3e-280 pipD E Dipeptidase
COFKGGJM_01624 2.8e-168 corA P CorA-like Mg2+ transporter protein
COFKGGJM_01625 1.8e-167 rluA 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
COFKGGJM_01626 7.3e-130 terC P membrane
COFKGGJM_01627 1.5e-55 trxA O Belongs to the thioredoxin family
COFKGGJM_01628 3.9e-235 mepA V MATE efflux family protein
COFKGGJM_01629 9.9e-55 K Transcriptional regulator, ArsR family
COFKGGJM_01630 7.4e-95 P Cadmium resistance transporter
COFKGGJM_01631 4.8e-137 XK27_08845 S ABC transporter, ATP-binding protein
COFKGGJM_01632 1.1e-153 XK27_08840 U Belongs to the binding-protein-dependent transport system permease family
COFKGGJM_01633 4.1e-181 ABC-SBP S ABC transporter
COFKGGJM_01634 1.7e-73 M PFAM NLP P60 protein
COFKGGJM_01635 6e-98 S Protein of unknown function (DUF3278)
COFKGGJM_01636 1e-28 WQ51_00220 K Helix-turn-helix domain
COFKGGJM_01637 4.5e-51 L Integrase
COFKGGJM_01638 1.1e-13 K Transcriptional
COFKGGJM_01639 6.2e-95 cadD P Cadmium resistance transporter
COFKGGJM_01640 6.1e-55 cadX K Bacterial regulatory protein, arsR family
COFKGGJM_01641 8.2e-72 arsC 1.20.4.1 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
COFKGGJM_01642 4.3e-181 arsB 1.20.4.1 P Sodium Bile acid symporter family
COFKGGJM_01643 2.4e-34 arsR K helix_turn_helix, Arsenical Resistance Operon Repressor
COFKGGJM_01644 6.4e-08 S HTH domain
COFKGGJM_01645 7.1e-273 S ABC transporter, ATP-binding protein
COFKGGJM_01646 5e-142 S Putative ABC-transporter type IV
COFKGGJM_01647 1.1e-104 NU mannosyl-glycoprotein
COFKGGJM_01648 1.2e-247 brnQ U Component of the transport system for branched-chain amino acids
COFKGGJM_01649 6.2e-227 S Uncharacterized protein conserved in bacteria (DUF2325)
COFKGGJM_01650 8.9e-206 nrnB S DHHA1 domain
COFKGGJM_01651 9.1e-49
COFKGGJM_01652 4.2e-29 3.6.4.12 S PD-(D/E)XK nuclease family transposase
COFKGGJM_01653 5.3e-16 S Domain of unknown function (DUF4767)
COFKGGJM_01654 1.5e-52
COFKGGJM_01655 1.5e-118 yrkL S Flavodoxin-like fold
COFKGGJM_01657 5.9e-64 yeaO S Protein of unknown function, DUF488
COFKGGJM_01658 5.2e-121 mpg 3.2.2.21 L Belongs to the DNA glycosylase MPG family
COFKGGJM_01659 4.4e-203 3.1.3.1 S associated with various cellular activities
COFKGGJM_01660 2.1e-230 S Putative metallopeptidase domain
COFKGGJM_01661 1.9e-46
COFKGGJM_01662 0.0 pepO 3.4.24.71 O Peptidase family M13
COFKGGJM_01663 3e-99 K Helix-turn-helix XRE-family like proteins
COFKGGJM_01664 3.9e-87 ymdB S Macro domain protein
COFKGGJM_01665 4.9e-194 EGP Major facilitator Superfamily
COFKGGJM_01666 7.1e-286 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
COFKGGJM_01667 6.2e-10 K helix_turn_helix, mercury resistance
COFKGGJM_01668 4.8e-168 cysK 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
COFKGGJM_01669 7.2e-155 metAA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to
COFKGGJM_01670 0.0 ysaB V FtsX-like permease family
COFKGGJM_01671 7.1e-133 macB2 V ABC transporter, ATP-binding protein
COFKGGJM_01672 2.8e-182 T PhoQ Sensor
COFKGGJM_01673 7e-124 K response regulator
COFKGGJM_01674 1.5e-155 ytbE 1.1.1.346 S Aldo keto reductase
COFKGGJM_01675 2.9e-134 pnuC H nicotinamide mononucleotide transporter
COFKGGJM_01676 1.1e-81 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
COFKGGJM_01677 1.1e-201
COFKGGJM_01678 2e-52
COFKGGJM_01679 9.1e-36
COFKGGJM_01680 5.3e-92 yxkA S Phosphatidylethanolamine-binding protein
COFKGGJM_01681 1.9e-144 ptp3 3.1.3.48 T Tyrosine phosphatase family
COFKGGJM_01682 2.1e-177 celE 3.2.1.4 GH5,GH9 E GDSL-like Lipase/Acylhydrolase family
COFKGGJM_01683 1.1e-225 galK 2.7.1.6 F Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
COFKGGJM_01684 1.5e-277 galT 2.7.7.12 G UDP-glucose--hexose-1-phosphate uridylyltransferase
COFKGGJM_01685 7.7e-180 galR K Transcriptional regulator
COFKGGJM_01686 3e-97 dedA 3.1.3.1 S SNARE associated Golgi protein
COFKGGJM_01687 1.6e-228 gltP U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
COFKGGJM_01688 1.4e-78 K AsnC family
COFKGGJM_01689 1.6e-79 uspA T universal stress protein
COFKGGJM_01690 3.4e-43 ltrA S Bacterial low temperature requirement A protein (LtrA)
COFKGGJM_01691 7.5e-57 ltrA S Bacterial low temperature requirement A protein (LtrA)
COFKGGJM_01692 7e-204 amtB P ammonium transporter
COFKGGJM_01693 2e-247 gor 1.8.1.7 C pyridine nucleotide-disulfide oxidoreductase
COFKGGJM_01694 8.6e-84 yvbK 3.1.3.25 K GNAT family
COFKGGJM_01695 4.8e-91
COFKGGJM_01696 2.2e-122 pnb C nitroreductase
COFKGGJM_01697 3.1e-75 ogt 2.1.1.63 L Methyltransferase
COFKGGJM_01702 1.1e-173 MA20_14895 S Conserved hypothetical protein 698
COFKGGJM_01703 1.5e-62
COFKGGJM_01704 1.4e-105
COFKGGJM_01705 1.4e-206 potD P ABC transporter
COFKGGJM_01706 6.5e-140 potC P ABC transporter permease
COFKGGJM_01707 3.9e-145 potB P ABC transporter permease
COFKGGJM_01708 2e-205 potA 3.6.3.30, 3.6.3.31 P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
COFKGGJM_01709 1.3e-16 L Transposase
COFKGGJM_01710 1e-36 L Helix-turn-helix domain
COFKGGJM_01711 8.7e-122 O Zinc-dependent metalloprotease
COFKGGJM_01712 2.6e-88 luxS 4.4.1.21 H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
COFKGGJM_01713 3.8e-159 metQ_4 P Belongs to the nlpA lipoprotein family
COFKGGJM_01715 3.5e-180 1.1.1.28 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
COFKGGJM_01717 6.6e-35 S Transglycosylase associated protein
COFKGGJM_01718 8.6e-232 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
COFKGGJM_01719 5e-127 3.1.3.73 G phosphoglycerate mutase
COFKGGJM_01720 1.2e-115 dedA S SNARE associated Golgi protein
COFKGGJM_01721 6.5e-111
COFKGGJM_01724 5.9e-149 yjjH S Calcineurin-like phosphoesterase
COFKGGJM_01725 1.7e-263 dtpT U amino acid peptide transporter
COFKGGJM_01728 1.3e-122 yciB M ErfK YbiS YcfS YnhG
COFKGGJM_01730 1.7e-97
COFKGGJM_01731 2.4e-215 dacA 3.4.16.4 M Belongs to the peptidase S11 family
COFKGGJM_01732 2.3e-43 S Alpha beta hydrolase
COFKGGJM_01733 4.6e-64 S Alpha beta hydrolase
COFKGGJM_01734 5.6e-56 L Resolvase, N terminal domain
COFKGGJM_01735 2.4e-12 L Resolvase, N terminal domain
COFKGGJM_01736 1.2e-08 dnaQ 2.7.7.7 L Psort location Cytoplasmic, score 8.87
COFKGGJM_01742 2.6e-15 K Cro/C1-type HTH DNA-binding domain
COFKGGJM_01743 2.1e-216 L Transposase IS66 family
COFKGGJM_01744 5.4e-281 L Transposase IS66 family
COFKGGJM_01745 3.1e-62 XK27_01125 L PFAM IS66 Orf2 family protein
COFKGGJM_01747 1.1e-42 L Transposase IS66 family
COFKGGJM_01748 0.0 nrdD 1.1.98.6 F Ribonucleoside-triphosphate reductase
COFKGGJM_01749 7.6e-111 nrdG 1.97.1.4 O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
COFKGGJM_01750 1.2e-158 sufD O Uncharacterized protein family (UPF0051)
COFKGGJM_01751 3.5e-42 lytE M LysM domain protein
COFKGGJM_01752 0.0 oppD EP Psort location Cytoplasmic, score
COFKGGJM_01753 7.3e-84 lytE M LysM domain protein
COFKGGJM_01754 1.3e-147 xth 3.1.11.2 L exodeoxyribonuclease III
COFKGGJM_01755 2.8e-235 preT 1.3.1.1 E Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
COFKGGJM_01756 1.2e-236 preA 1.3.1.1 C 4Fe-4S dicluster domain
COFKGGJM_01757 2.9e-151 yeaE S Aldo keto
COFKGGJM_01758 7.7e-76 hsp O Belongs to the small heat shock protein (HSP20) family
COFKGGJM_01759 8.7e-284 dinB 2.7.7.7 L impB/mucB/samB family C-terminal domain
COFKGGJM_01760 2.9e-78 S Psort location Cytoplasmic, score
COFKGGJM_01761 2.2e-85 S Short repeat of unknown function (DUF308)
COFKGGJM_01762 1e-23
COFKGGJM_01763 1.7e-102 V VanZ like family
COFKGGJM_01764 1.6e-228 cycA E Amino acid permease
COFKGGJM_01765 2.8e-84 perR P Belongs to the Fur family
COFKGGJM_01766 7.9e-258 EGP Major facilitator Superfamily
COFKGGJM_01767 6.7e-93 tag 3.2.2.20 L glycosylase
COFKGGJM_01768 1.9e-217 metK 2.5.1.6 H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
COFKGGJM_01769 0.0 leuS 6.1.1.4 J Belongs to the class-I aminoacyl-tRNA synthetase family
COFKGGJM_01770 7.6e-42
COFKGGJM_01771 1.1e-300 ytgP S Polysaccharide biosynthesis protein
COFKGGJM_01772 5.4e-153 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
COFKGGJM_01773 8.1e-276 pepV 3.5.1.18 E dipeptidase PepV
COFKGGJM_01774 7.3e-86 uspA T Belongs to the universal stress protein A family
COFKGGJM_01775 2.1e-175 NU Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
COFKGGJM_01776 5e-116 dck 2.7.1.74 F deoxynucleoside kinase
COFKGGJM_01777 2.5e-112
COFKGGJM_01778 8.7e-187 rbsR K Periplasmic binding proteins and sugar binding domain of LacI family
COFKGGJM_01779 3e-162 rbsK 2.7.1.15 H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
COFKGGJM_01780 1.8e-31
COFKGGJM_01781 2.7e-109 S CAAX protease self-immunity
COFKGGJM_01782 1.9e-43
COFKGGJM_01784 2e-67
COFKGGJM_01785 2.6e-55 folB 1.13.11.81, 2.5.1.15, 2.7.6.3, 4.1.2.25, 5.1.99.8 H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
COFKGGJM_01786 2.9e-90 folK 1.13.11.81, 2.5.1.15, 2.7.6.3, 3.5.4.16, 4.1.2.25, 5.1.99.8 H 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)
COFKGGJM_01787 2.6e-103 folE 2.7.6.3, 3.5.4.16 F GTP cyclohydrolase 1
COFKGGJM_01788 1.8e-221 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
COFKGGJM_01789 5.4e-104 xtp 2.5.1.15, 3.6.1.66 F Ham1 family
COFKGGJM_01790 1.3e-213 folP 2.5.1.15 H dihydropteroate synthase
COFKGGJM_01791 1.4e-43
COFKGGJM_01792 1.3e-36
COFKGGJM_01794 4.2e-167 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
COFKGGJM_01795 7.3e-152 thiD 2.5.1.3, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Phosphomethylpyrimidine kinase
COFKGGJM_01796 0.0 argS 6.1.1.19 J Arginyl-tRNA synthetase
COFKGGJM_01797 0.0 pbp2A 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
COFKGGJM_01798 1.3e-42 yheA S Belongs to the UPF0342 family
COFKGGJM_01799 1.3e-221 yhaO L Ser Thr phosphatase family protein
COFKGGJM_01800 0.0 L AAA domain
COFKGGJM_01801 8.5e-128 prsA 5.2.1.8 M Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins
COFKGGJM_01803 1.2e-76 hit FG histidine triad
COFKGGJM_01804 6.7e-136 ecsA V ABC transporter, ATP-binding protein
COFKGGJM_01805 3.9e-218 ecsB U ABC transporter
COFKGGJM_01806 3.1e-121 trmB 2.1.1.297, 2.1.1.33 J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
COFKGGJM_01807 2.5e-16 S YSIRK type signal peptide
COFKGGJM_01808 9.5e-16 2.1.1.72, 3.1.21.3 AA10,CBM73 L Belongs to the N(4) N(6)-methyltransferase family
COFKGGJM_01809 4.5e-13 2.1.1.72, 3.1.21.3 AA10,CBM73 L Belongs to the N(4) N(6)-methyltransferase family
COFKGGJM_01810 3.8e-64 2.1.1.72, 3.1.21.3 AA10,CBM73 L Belongs to the N(4) N(6)-methyltransferase family
COFKGGJM_01811 1.3e-10 glsA 3.5.1.2 E Belongs to the glutaminase family
COFKGGJM_01812 7.5e-58 ytzB S Small secreted protein
COFKGGJM_01813 1.7e-56 ytpP 2.7.1.180, 5.3.4.1 CO Thioredoxin
COFKGGJM_01814 2.9e-119 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
COFKGGJM_01815 1.3e-251 mpl 6.3.2.4, 6.3.2.45, 6.3.2.8 M Belongs to the MurCDEF family
COFKGGJM_01816 1.9e-119 ybhL S Belongs to the BI1 family
COFKGGJM_01817 8.3e-61 yoaK S Protein of unknown function (DUF1275)
COFKGGJM_01818 5.5e-43 yoaK S Protein of unknown function (DUF1275)
COFKGGJM_01819 0.0 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
COFKGGJM_01820 1.2e-157 fpg 3.2.2.23, 4.2.99.18 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
COFKGGJM_01821 1e-97 coaE 2.7.1.24 F Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
COFKGGJM_01822 1.1e-80 nrdR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
COFKGGJM_01823 3e-222 dnaB L replication initiation and membrane attachment
COFKGGJM_01824 1.9e-172 dnaI L Primosomal protein DnaI
COFKGGJM_01825 3.7e-85 infC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
COFKGGJM_01826 2.3e-27 rpmI J Belongs to the bacterial ribosomal protein bL35 family
COFKGGJM_01827 3.3e-56 rplT J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
COFKGGJM_01828 1.2e-84 L Belongs to the 'phage' integrase family
COFKGGJM_01829 1.5e-30 DV (ABC) transporter
COFKGGJM_01830 4.8e-126 O Bacterial dnaA protein
COFKGGJM_01831 2.8e-208 L Integrase core domain
COFKGGJM_01832 5.8e-184 S Phosphotransferase system, EIIC
COFKGGJM_01833 6.4e-99 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
COFKGGJM_01834 1.5e-181
COFKGGJM_01835 4.5e-175 fecB P Periplasmic binding protein
COFKGGJM_01836 1.3e-171
COFKGGJM_01837 2.8e-73
COFKGGJM_01839 7.2e-128 tesE Q hydratase
COFKGGJM_01840 8.8e-117 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
COFKGGJM_01843 1.9e-11 L Resolvase, N terminal domain
COFKGGJM_01844 1.4e-59 L Resolvase, N terminal domain
COFKGGJM_01845 0.0 yhcA V ABC transporter, ATP-binding protein
COFKGGJM_01846 2.5e-36
COFKGGJM_01847 1.3e-67 L Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
COFKGGJM_01848 6.5e-58 kgtP EGP Sugar (and other) transporter
COFKGGJM_01849 1.5e-138 L Bacterial dnaA protein
COFKGGJM_01850 1.2e-230 L Integrase core domain
COFKGGJM_01851 1.3e-19 3.2.1.18 GH33 M Rib/alpha-like repeat
COFKGGJM_01852 2.6e-239 yhjE EGP MFS transporter, metabolite H symporter (MHS) family protein
COFKGGJM_01853 1.2e-129 IQ Dehydrogenase reductase
COFKGGJM_01854 3.2e-36
COFKGGJM_01855 5.1e-99 ywnB S NAD(P)H-binding
COFKGGJM_01856 2.9e-37 S Cytochrome b5-like Heme/Steroid binding domain
COFKGGJM_01857 1.2e-253 nhaC C Na H antiporter NhaC
COFKGGJM_01858 3.8e-182 P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
COFKGGJM_01860 4.1e-98 ydeN S Serine hydrolase
COFKGGJM_01861 2.9e-27 psiE S Phosphate-starvation-inducible E
COFKGGJM_01862 8.5e-142 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
COFKGGJM_01864 4.1e-178 S Aldo keto reductase
COFKGGJM_01865 1.6e-64 3.1.3.27, 3.1.3.4, 3.1.3.81, 3.6.1.27 I PAP2 superfamily
COFKGGJM_01866 0.0 L Helicase C-terminal domain protein
COFKGGJM_01868 2.9e-246 merA 1.16.1.1, 1.8.1.7 C Pyridine nucleotide-disulfide oxidoreductase
COFKGGJM_01869 2.6e-52 S Sugar efflux transporter for intercellular exchange
COFKGGJM_01870 3.2e-119
COFKGGJM_01872 2.4e-220 5.4.2.7 G Metalloenzyme superfamily
COFKGGJM_01873 1.3e-310 cadA P P-type ATPase
COFKGGJM_01874 2.8e-126 XK27_08875 O PFAM peptidase M10A and M12B, matrixin and adamalysin
COFKGGJM_01875 1.1e-50 1.6.5.2 GM NAD(P)H-binding
COFKGGJM_01876 3.4e-74 K Transcriptional regulator
COFKGGJM_01877 6e-163 proX M ABC transporter, substrate-binding protein, QAT family
COFKGGJM_01878 2.4e-108 proWZ P ABC transporter permease
COFKGGJM_01879 6.5e-142 proV E ABC transporter, ATP-binding protein
COFKGGJM_01880 1.9e-102 proW P ABC transporter, permease protein
COFKGGJM_01881 2e-79 msrB 1.8.4.11, 1.8.4.12 O peptide methionine sulfoxide reductase
COFKGGJM_01882 1.1e-57 clcA P chloride
COFKGGJM_01883 2.3e-54 clcA P chloride
COFKGGJM_01884 5.5e-214 argE 3.5.1.18 E succinyl-diaminopimelate desuccinylase
COFKGGJM_01885 6.2e-45 metI P ABC transporter permease
COFKGGJM_01886 5.3e-41 metI P ABC transporter permease
COFKGGJM_01887 1.4e-190 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
COFKGGJM_01888 2.8e-154 metQ1 P Belongs to the nlpA lipoprotein family
COFKGGJM_01889 5.8e-169 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
COFKGGJM_01890 8.3e-221 norA EGP Major facilitator Superfamily
COFKGGJM_01891 8.9e-41 1.3.5.4 S FMN binding
COFKGGJM_01892 9.3e-118 nth 4.2.99.18 L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
COFKGGJM_01893 1.7e-263 yfnA E amino acid
COFKGGJM_01894 1.7e-232 gabT 2.6.1.19 E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
COFKGGJM_01896 2.4e-204 napA P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
COFKGGJM_01897 0.0 helD 3.6.4.12 L DNA helicase
COFKGGJM_01898 6.3e-81 ndk 2.7.4.6 F Belongs to the NDK family
COFKGGJM_01899 1e-181 hpaIM 2.1.1.72 L Belongs to the N(4) N(6)-methyltransferase family
COFKGGJM_01900 7.7e-191 trpS 6.1.1.2 J Belongs to the class-I aminoacyl-tRNA synthetase family
COFKGGJM_01901 1.8e-165 ppx 3.6.1.11, 3.6.1.40 FP exopolyphosphatase
COFKGGJM_01902 9.7e-228 mvaA 1.1.1.34, 1.1.1.88, 2.3.1.9 C Belongs to the HMG-CoA reductase family
COFKGGJM_01903 1.2e-174
COFKGGJM_01904 7.5e-129 cobB K SIR2 family
COFKGGJM_01906 6.9e-161 yunF F Protein of unknown function DUF72
COFKGGJM_01907 0.0 metG 6.1.1.10 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
COFKGGJM_01908 3.5e-154 tatD L hydrolase, TatD family
COFKGGJM_01909 3.2e-98 rnmV 3.1.26.8 J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
COFKGGJM_01910 9.5e-161 ksgA 2.1.1.182 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
COFKGGJM_01911 6.8e-37 veg S Biofilm formation stimulator VEG
COFKGGJM_01912 3.1e-161 ispE 2.1.1.182, 2.7.1.148 F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
COFKGGJM_01913 1.8e-167 znuA P Belongs to the bacterial solute-binding protein 9 family
COFKGGJM_01914 2.2e-122 fhuC P ABC transporter
COFKGGJM_01915 4.7e-127 znuB U ABC 3 transport family
COFKGGJM_01916 1.2e-149 purR 2.4.2.22, 2.4.2.7 F pur operon repressor
COFKGGJM_01917 2.7e-239 glmU 2.3.1.157, 2.7.7.23 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
COFKGGJM_01918 1.1e-178 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
COFKGGJM_01919 9e-48
COFKGGJM_01920 3e-145 yxeH S hydrolase
COFKGGJM_01921 1e-270 ywfO S HD domain protein
COFKGGJM_01922 3.4e-149 lipL 2.3.1.200, 2.3.1.204 H biotin lipoate A B protein ligase
COFKGGJM_01942 6.7e-27 mnaA 5.1.3.14 G Belongs to the UDP-N-acetylglucosamine 2-epimerase family
COFKGGJM_01943 3.4e-80 M Glycosyl transferase family group 2
COFKGGJM_01944 2.4e-81 M Glycosyl transferase family group 2
COFKGGJM_01945 9.3e-27 M Glycosyl transferase family group 2
COFKGGJM_01946 1.9e-63 lmrB EGP Major facilitator Superfamily
COFKGGJM_01947 2.1e-133 lmrB EGP Major facilitator Superfamily
COFKGGJM_01948 3.3e-260 L Transposase
COFKGGJM_01949 5.2e-170 L Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
COFKGGJM_01955 2.9e-151 S Phosphotransferase system, EIIC
COFKGGJM_01956 3.8e-218 tnpB L Putative transposase DNA-binding domain
COFKGGJM_01957 2.2e-229 L transposase, IS605 OrfB family
COFKGGJM_01958 2.3e-209 L transposase IS116 IS110 IS902 family protein
COFKGGJM_01959 0.0 lacS G Transporter
COFKGGJM_01960 2.3e-28
COFKGGJM_01961 7.1e-275 gnd 1.1.1.343, 1.1.1.44 H Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
COFKGGJM_01962 2.4e-286 zwf 1.1.1.363, 1.1.1.49 G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
COFKGGJM_01963 4.4e-190 yeaN P Transporter, major facilitator family protein
COFKGGJM_01964 2.7e-73 S 3-demethylubiquinone-9 3-methyltransferase
COFKGGJM_01965 2.7e-82 nrdI F Belongs to the NrdI family
COFKGGJM_01966 1.6e-236 yhdP S Transporter associated domain
COFKGGJM_01967 1.1e-153 ypdB V (ABC) transporter
COFKGGJM_01968 2.5e-89 1.14.14.47, 1.6.5.3, 1.6.99.3 GM epimerase
COFKGGJM_01969 1.1e-89 M1-874 K Domain of unknown function (DUF1836)
COFKGGJM_01970 2.3e-78 yybA 2.3.1.57 K Transcriptional regulator
COFKGGJM_01971 1.7e-131 XK27_07210 6.1.1.6 S B3 4 domain
COFKGGJM_01972 2.6e-160 S AI-2E family transporter
COFKGGJM_01973 1.3e-156 3.2.1.52 GH20 G Xylose isomerase domain protein TIM barrel
COFKGGJM_01974 4.9e-160
COFKGGJM_01975 1e-133 glpF U Belongs to the MIP aquaporin (TC 1.A.8) family
COFKGGJM_01976 3.6e-138 eutJ E Hsp70 protein
COFKGGJM_01977 8.3e-159 K helix_turn_helix, arabinose operon control protein
COFKGGJM_01978 1.6e-37 pduA_4 CQ BMC
COFKGGJM_01979 2.7e-134 pduB E BMC
COFKGGJM_01980 0.0 pduC 4.2.1.28 Q Dehydratase large subunit
COFKGGJM_01981 3.9e-125 pduD 4.2.1.28, 4.2.1.30 Q Dehydratase medium subunit
COFKGGJM_01982 2.4e-71 pduE 4.2.1.28 Q Dehydratase small subunit
COFKGGJM_01983 5.6e-309 pduG D Diol dehydratase reactivase ATPase-like domain
COFKGGJM_01984 2.6e-45 pduH S Dehydratase medium subunit
COFKGGJM_01985 1.8e-56 pduK CQ BMC
COFKGGJM_01986 7.8e-40 pduA_4 CQ BMC
COFKGGJM_01987 1.9e-115 pduL 2.3.1.222, 2.3.1.8 Q Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate
COFKGGJM_01988 1.3e-79 S Putative propanediol utilisation
COFKGGJM_01989 5.2e-41 ccmL CQ Ethanolamine utilisation protein EutN/carboxysome
COFKGGJM_01990 1e-102 pduO 2.5.1.17 S Cobalamin adenosyltransferase
COFKGGJM_01991 4.5e-77 pduO S Haem-degrading
COFKGGJM_01992 3.1e-262 pduP 1.2.1.87 C Aldehyde dehydrogenase family
COFKGGJM_01993 2.1e-202 pduQ C Iron-containing alcohol dehydrogenase
COFKGGJM_01994 2.5e-217 ackA 2.7.2.1, 2.7.2.15 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
COFKGGJM_01995 3e-54 pduU E BMC
COFKGGJM_01996 1.1e-115 3.1.3.48 T Pfam:Y_phosphatase3C
COFKGGJM_01997 1.9e-75 pgm1 3.1.3.73 G phosphoglycerate mutase
COFKGGJM_01998 5.9e-68 P Cadmium resistance transporter
COFKGGJM_01999 2.6e-68 eutP E Ethanolamine utilisation - propanediol utilisation
COFKGGJM_02000 2.2e-73 fld C Flavodoxin
COFKGGJM_02001 8.7e-116 XK27_04590 S NADPH-dependent FMN reductase
COFKGGJM_02002 3.2e-77 cobO 2.5.1.17 S Cobalamin adenosyltransferase
COFKGGJM_02003 6.1e-170 cobD 4.1.1.81 E Aminotransferase class I and II
COFKGGJM_02004 7.3e-205 cbiA 6.3.5.11, 6.3.5.9 F Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source
COFKGGJM_02005 4.9e-147 cobD 6.3.1.10 H Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
COFKGGJM_02006 3.8e-109 cbiC 5.4.99.60, 5.4.99.61 H Precorrin-8X methylmutase
COFKGGJM_02007 6.4e-186 cbiD 2.1.1.195 H Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
COFKGGJM_02008 1.6e-79 cbiE 2.1.1.132, 2.1.1.289 H Tetrapyrrole (Corrin/Porphyrin) Methylases
COFKGGJM_02009 1.4e-77 cbiT 2.1.1.132, 2.1.1.196 H Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
COFKGGJM_02010 8.1e-129 cobM 1.3.1.76, 2.1.1.131, 2.1.1.133, 2.1.1.271, 3.7.1.12, 4.99.1.4 H Tetrapyrrole (Corrin/Porphyrin) Methylases
COFKGGJM_02011 4.3e-144 cbiG 2.1.1.131, 2.1.1.133, 2.1.1.271, 3.7.1.12 H Cobalamin synthesis G C-terminus
COFKGGJM_02012 1.1e-127 cobJ 2.1.1.131, 2.1.1.133, 2.1.1.271, 3.7.1.12, 6.3.5.10 H Tetrapyrrole (Corrin/Porphyrin) Methylases
COFKGGJM_02013 2.8e-97 cobK 1.3.1.106, 1.3.1.54, 2.1.1.195 H Precorrin-6x reductase CbiJ/CobK
COFKGGJM_02014 1.6e-175 cobA 2.1.1.107, 4.2.1.75 H Tetrapyrrole (Corrin/Porphyrin) Methylases
COFKGGJM_02015 6.2e-108 cbiK 4.99.1.3 H Cobalt chelatase (CbiK)
COFKGGJM_02016 8.1e-91 cobI 2.1.1.130, 2.1.1.151, 4.99.1.3 H Tetrapyrrole (Corrin/Porphyrin) Methylases
COFKGGJM_02017 4.5e-124 cbiM P Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
COFKGGJM_02018 7.6e-44 cbiN P Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
COFKGGJM_02019 6.8e-103 cbiQ P Cobalt transport protein
COFKGGJM_02020 7.8e-122 cbiO 2.1.1.195 P part of an ABC transporter complex. Responsible for energy coupling to the transport system
COFKGGJM_02021 2.7e-240 cobQ 6.3.5.10 H Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation
COFKGGJM_02022 7e-59 cysG 1.3.1.76, 4.99.1.4 H Putative NAD(P)-binding
COFKGGJM_02023 4.1e-194 hemA 1.2.1.70 H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
COFKGGJM_02024 2.6e-137 hemC 2.1.1.107, 2.5.1.61, 4.2.1.75 H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
COFKGGJM_02025 2.8e-174 hemB 4.2.1.24 H Delta-aminolevulinic acid dehydratase
COFKGGJM_02026 1.1e-239 hemL 5.4.3.8 H Aminotransferase class-III
COFKGGJM_02027 1.6e-76 cobU 2.7.1.156, 2.7.7.62, 6.3.5.10 H Cobinamide kinase / cobinamide phosphate guanyltransferase
COFKGGJM_02028 2.2e-118 cobS 2.7.8.26 H Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
COFKGGJM_02029 5.8e-74 gpm 3.1.3.73, 5.4.2.12 G Belongs to the phosphoglycerate mutase family
COFKGGJM_02030 6.5e-64 hemD 2.1.1.107, 4.2.1.75 H Uroporphyrinogen-III synthase
COFKGGJM_02031 2e-146 cobT 2.4.2.21, 6.3.5.11, 6.3.5.9 F Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)
COFKGGJM_02032 2.1e-260 S Uncharacterised protein family (UPF0236)
COFKGGJM_02034 3.9e-237 L Transposase
COFKGGJM_02035 1.9e-112 L PFAM Integrase catalytic region
COFKGGJM_02036 6e-117 L PFAM Integrase catalytic region
COFKGGJM_02037 7.6e-164 L PFAM Integrase catalytic region
COFKGGJM_02038 1.4e-51 L PFAM Integrase catalytic region
COFKGGJM_02039 6.3e-18
COFKGGJM_02041 6.3e-37 ltrA_1 L PFAM RNA-directed DNA polymerase (Reverse transcriptase)
COFKGGJM_02042 1.2e-249 serS 6.1.1.11 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
COFKGGJM_02043 2.2e-263 glnP P ABC transporter
COFKGGJM_02044 1.9e-138 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
COFKGGJM_02045 1.6e-220 cycA E Amino acid permease
COFKGGJM_02046 1.3e-218 nupG F Nucleoside transporter
COFKGGJM_02047 6.6e-170 rihC 3.2.2.1 F Nucleoside
COFKGGJM_02048 7.7e-163 fadB4 1.1.1.157 I 3-hydroxyacyl-CoA dehydrogenase
COFKGGJM_02049 3.7e-123 rsmG 2.1.1.170 J Specifically methylates the N7 position of a guanine in 16S rRNA
COFKGGJM_02050 1.5e-143 noc K Belongs to the ParB family
COFKGGJM_02051 3.6e-140 soj D Sporulation initiation inhibitor
COFKGGJM_02052 5e-154 spo0J K Belongs to the ParB family
COFKGGJM_02053 1.2e-31 yyzM S Bacterial protein of unknown function (DUF951)
COFKGGJM_02054 2e-200 ychF J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
COFKGGJM_02055 3.1e-136 XK27_01040 S Protein of unknown function (DUF1129)
COFKGGJM_02056 3.4e-118 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
COFKGGJM_02057 4.5e-235 deoB 5.4.2.7 G Phosphotransfer between the C1 and C5 carbon atoms of pentose
COFKGGJM_02058 3.2e-234 pdp 2.4.2.2, 2.4.2.4 F pyrimidine-nucleoside phosphorylase
COFKGGJM_02059 1.1e-130 deoD 2.4.2.1, 2.4.2.28 F Purine nucleoside phosphorylase
COFKGGJM_02060 4e-170 deoR K sugar-binding domain protein
COFKGGJM_02061 2e-208 guaB 1.1.1.205 F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
COFKGGJM_02062 3.8e-125 K response regulator
COFKGGJM_02063 8.3e-202 hpk31 2.7.13.3 T Histidine kinase
COFKGGJM_02064 2.3e-138 azlC E AzlC protein
COFKGGJM_02065 1.6e-52 azlD S branched-chain amino acid
COFKGGJM_02066 2.9e-124 K LysR substrate binding domain
COFKGGJM_02067 5e-173 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
COFKGGJM_02068 3.6e-246 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
COFKGGJM_02069 2.1e-171 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
COFKGGJM_02070 6e-129 pyrF 4.1.1.23 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
COFKGGJM_02071 9.6e-115 pyrE 2.4.2.10, 4.1.1.23 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
COFKGGJM_02072 3.7e-114 thiE 2.5.1.3, 2.7.6.2, 5.4.2.6 S Haloacid dehalogenase-like hydrolase
COFKGGJM_02073 7.9e-96 ribA 3.5.4.25, 4.1.99.12 H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
COFKGGJM_02074 1.8e-228 cfa 2.1.1.317, 2.1.1.79 M cyclopropane-fatty-acyl-phospholipid synthase
COFKGGJM_02075 1.1e-173 K AI-2E family transporter
COFKGGJM_02076 0.0 fhs 6.3.4.3 F Belongs to the formate--tetrahydrofolate ligase family
COFKGGJM_02077 0.0 alsS 2.2.1.6 EH Belongs to the TPP enzyme family
COFKGGJM_02078 6.5e-128 budA 4.1.1.5 H Belongs to the alpha-acetolactate decarboxylase family
COFKGGJM_02079 1.7e-19 mocA S Oxidoreductase
COFKGGJM_02080 3.5e-24 K helix_turn_helix, arabinose operon control protein
COFKGGJM_02081 1.4e-185 thrC 4.2.3.1 E Threonine synthase
COFKGGJM_02082 5.8e-172 hom 1.1.1.3, 2.7.2.4 E homoserine dehydrogenase
COFKGGJM_02083 1.4e-100 thrB 2.7.1.39 F Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
COFKGGJM_02084 4e-81 purE 5.4.99.18 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
COFKGGJM_02085 3.9e-215 purK 6.3.4.18 F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
COFKGGJM_02086 2e-252 purB 4.3.2.2 F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
COFKGGJM_02087 6.3e-131 purC 4.1.1.21, 4.3.2.2, 6.3.2.6 F Belongs to the SAICAR synthetase family
COFKGGJM_02088 1.8e-37 purS 6.3.2.6, 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
COFKGGJM_02089 3.1e-127 purQ 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
COFKGGJM_02090 0.0 purL 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
COFKGGJM_02091 2e-277 purF 2.4.2.14 F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
COFKGGJM_02092 6.2e-196 purM 6.3.3.1, 6.3.4.13 F Phosphoribosylformylglycinamidine cyclo-ligase
COFKGGJM_02093 8e-105 purN 2.1.2.2 F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
COFKGGJM_02094 2.3e-295 purH 2.1.2.3, 3.5.4.10 F Bifunctional purine biosynthesis protein PurH
COFKGGJM_02095 2.8e-243 purD 6.3.4.13 F Belongs to the GARS family
COFKGGJM_02096 1e-130 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
COFKGGJM_02097 1.8e-166
COFKGGJM_02098 3.5e-238 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)

eggNOG-mapper v2 (Database: eggNOG v5.0, Jul. 2018 release)