ORF_ID e_value Gene_name EC_number CAZy COGs Description
HMECEDPK_00001 1.2e-91 blpT
HMECEDPK_00002 2.9e-28 blpT
HMECEDPK_00003 6.8e-47 spiA K sequence-specific DNA binding
HMECEDPK_00006 0.0 pepX 3.4.14.11 E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline
HMECEDPK_00007 2.3e-164 gla U Belongs to the MIP aquaporin (TC 1.A.8) family
HMECEDPK_00008 5e-44 V CAAX protease self-immunity
HMECEDPK_00009 1.7e-139 cppA E CppA N-terminal
HMECEDPK_00010 6.5e-184 ampC V COG1680 Beta-lactamase class C and other penicillin binding proteins
HMECEDPK_00011 3.6e-117 ybbL S abc transporter atp-binding protein
HMECEDPK_00012 1.5e-127 ybbM S transport system, permease component
HMECEDPK_00013 2.9e-87 D nuclear chromosome segregation
HMECEDPK_00014 1e-44 hsdS_1 3.1.21.3 V type I restriction modification DNA specificity domain
HMECEDPK_00015 2.1e-85 yjcF S COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HMECEDPK_00016 1.8e-147 cah 4.2.1.1 P carbonic anhydrase
HMECEDPK_00017 0.0 pflB 2.3.1.54 C formate acetyltransferase'
HMECEDPK_00018 3.1e-206 dinB 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HMECEDPK_00020 1.5e-152 yxeM ET ABC-type amino acid transport signal transduction systems, periplasmic component domain
HMECEDPK_00021 1e-162 yxeN P ABC transporter (Permease
HMECEDPK_00022 4.5e-132 tcyN 3.6.3.21 E abc transporter atp-binding protein
HMECEDPK_00023 1.9e-09 S Protein of unknown function (DUF4059)
HMECEDPK_00024 1.9e-172 trxB 1.8.1.9 C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
HMECEDPK_00025 5.1e-93 rsmD 2.1.1.171 L Methyltransferase
HMECEDPK_00026 2.7e-88 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HMECEDPK_00027 2.2e-196 ylbL T Belongs to the peptidase S16 family
HMECEDPK_00028 1.3e-184 yhcC S radical SAM protein
HMECEDPK_00029 1.4e-98 ytqB 2.1.1.176 J (SAM)-dependent
HMECEDPK_00031 0.0 yjcE P NhaP-type Na H and K H antiporters
HMECEDPK_00032 2.4e-144 modF 3.6.3.21, 3.6.3.34 P abc transporter atp-binding protein
HMECEDPK_00033 2e-239 hlyX S COG1253 Hemolysins and related proteins containing CBS domains
HMECEDPK_00034 2e-157 pflA 1.97.1.4 C Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HMECEDPK_00037 2.4e-75 XK27_03180 T universal stress protein
HMECEDPK_00038 3.7e-240 alaA 2.6.1.2, 2.6.1.66 E Aminotransferase
HMECEDPK_00039 1.2e-140 codY K DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HMECEDPK_00040 6.8e-101 pncA Q isochorismatase
HMECEDPK_00041 1.1e-153 hlpA M Belongs to the NlpA lipoprotein family
HMECEDPK_00042 1e-95 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HMECEDPK_00043 5.1e-77 ascB 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
HMECEDPK_00044 2.9e-148 ascB 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
HMECEDPK_00045 6.3e-31 M lipopolysaccharide 3-alpha-galactosyltransferase activity
HMECEDPK_00046 1.4e-47 gatC 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HMECEDPK_00047 3.5e-269 gatA 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
HMECEDPK_00048 2.3e-273 gatB 6.1.1.12, 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HMECEDPK_00049 1.3e-57
HMECEDPK_00050 1.1e-153 yicL EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
HMECEDPK_00051 1.8e-98 yqeG S hydrolase of the HAD superfamily
HMECEDPK_00052 8.4e-215 yqeH S in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis
HMECEDPK_00053 3.5e-49 yhbY J RNA-binding protein
HMECEDPK_00054 3.1e-118 nadD 2.7.7.18, 3.6.1.55 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HMECEDPK_00055 1.4e-107 nadD 2.7.6.3, 2.7.7.18 H HD superfamily hydrolase involved in NAD metabolism
HMECEDPK_00056 6e-58 rsfS J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
HMECEDPK_00057 2e-140 yqeM Q Methyltransferase domain protein
HMECEDPK_00058 6.9e-206 ylbM S Belongs to the UPF0348 family
HMECEDPK_00059 0.0 clpL O ATP-dependent Clp protease ATP-binding subunit
HMECEDPK_00060 8.1e-106
HMECEDPK_00061 5.6e-12
HMECEDPK_00062 3.9e-72 hit FG Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
HMECEDPK_00063 2.3e-133 ecsA V abc transporter atp-binding protein
HMECEDPK_00064 3e-182 ecsB U ABC transporter
HMECEDPK_00065 1.2e-151 ytmP 2.7.1.89 M Phosphotransferase
HMECEDPK_00066 3.1e-121 trmB 2.1.1.297, 2.1.1.33 J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
HMECEDPK_00068 7.7e-227 ytfP S Flavoprotein
HMECEDPK_00069 0.0 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
HMECEDPK_00070 4.8e-63 XK27_02560 S cog cog2151
HMECEDPK_00071 1.2e-41 WQ51_02910 S Protein of unknown function, DUF536
HMECEDPK_00072 1.4e-104 dnaQ 2.7.7.7 L DNA polymerase III
HMECEDPK_00073 2.7e-129 K transcriptional regulator, MerR family
HMECEDPK_00074 9.7e-28 L transposase activity
HMECEDPK_00075 1.2e-43 yaaK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HMECEDPK_00076 3.9e-26
HMECEDPK_00077 0.0 ctpE P E1-E2 ATPase
HMECEDPK_00078 3.2e-56
HMECEDPK_00079 3.7e-42 pchB 2.5.1.19, 4.2.1.10, 4.2.99.21, 5.4.99.5 E Chorismate mutase
HMECEDPK_00080 2.4e-256 trpE 4.1.3.27 EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HMECEDPK_00081 3.6e-105 trpG 2.4.2.18, 2.6.1.85, 4.1.3.27 EH anthranilate
HMECEDPK_00082 7.8e-180 trpD 2.4.2.18, 4.1.3.27 F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HMECEDPK_00083 2.5e-133 trpC 4.1.1.48, 5.3.1.24 E Belongs to the TrpC family
HMECEDPK_00084 3.3e-98 trpF 4.1.1.48, 4.2.1.160, 4.2.1.20, 5.3.1.24 E belongs to the TrpF family
HMECEDPK_00085 1.1e-228 trpB 4.2.1.20, 5.3.1.24 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HMECEDPK_00086 2.1e-143 trpA 4.2.1.20 E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
HMECEDPK_00087 2.7e-73 copY K Copper transport repressor, CopY TcrY family
HMECEDPK_00088 0.0 copA 3.6.3.54 P P-type ATPase
HMECEDPK_00089 2e-29 copZ 2.7.7.77 P Heavy metal-associated domain protein
HMECEDPK_00090 6.4e-193 ddl 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
HMECEDPK_00091 1e-114 papP P ABC transporter (Permease
HMECEDPK_00092 1.3e-114 P ABC transporter (Permease
HMECEDPK_00093 1.4e-136 glnQ 3.6.3.21 E abc transporter atp-binding protein
HMECEDPK_00094 1.1e-155 cjaA ET ABC transporter substrate-binding protein
HMECEDPK_00098 1.5e-258 murF 6.3.2.10 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
HMECEDPK_00099 1.4e-121 ywaF S Integral membrane protein (intg_mem_TP0381)
HMECEDPK_00100 3.1e-300 prfC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HMECEDPK_00101 6e-175 yjbB G Permeases of the major facilitator superfamily
HMECEDPK_00102 2.1e-157 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
HMECEDPK_00103 7.8e-100 thiT S Thiamine transporter
HMECEDPK_00104 1.9e-62 yjqA S Bacterial PH domain
HMECEDPK_00105 3.9e-154 corA P CorA-like protein
HMECEDPK_00106 3.2e-252 cshA 3.6.4.13 JKL DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
HMECEDPK_00107 1e-41 yazA L endonuclease containing a URI domain
HMECEDPK_00108 7.1e-141 yabB 2.1.1.223 L Methyltransferase
HMECEDPK_00109 1.5e-61 nodB3 G deacetylase
HMECEDPK_00110 4.4e-73 nodB3 G polysaccharide deacetylase
HMECEDPK_00111 1.3e-142 plsC 2.3.1.51 I Acyltransferase
HMECEDPK_00112 2.2e-96 comEA L COG1555 DNA uptake protein and related DNA-binding proteins
HMECEDPK_00113 0.0 comEC S Competence protein ComEC
HMECEDPK_00114 1e-232 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HMECEDPK_00115 2.4e-98 XK27_07830 2.3.1.128 J Acetyltransferase GNAT Family
HMECEDPK_00116 3.3e-231 ytoI K transcriptional regulator containing CBS domains
HMECEDPK_00117 1.5e-166 map 3.4.11.18 E Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed
HMECEDPK_00118 2.8e-163 rbn E Belongs to the UPF0761 family
HMECEDPK_00119 3.7e-85 ccl S cog cog4708
HMECEDPK_00120 0.0 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HMECEDPK_00121 5.7e-186 yegS 2.7.1.107 I Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
HMECEDPK_00122 4.9e-120 ribD 1.1.1.193, 3.5.4.26 L Transposase DDE domain
HMECEDPK_00123 2.1e-74 S QueT transporter
HMECEDPK_00124 1e-156 xth 3.1.11.2 L exodeoxyribonuclease III
HMECEDPK_00125 6.9e-172 tehB 2.1.1.265 PQ tellurite resistance protein tehb
HMECEDPK_00126 2.4e-43 rpsP J Belongs to the bacterial ribosomal protein bS16 family
HMECEDPK_00127 4.1e-37 ylqC L Belongs to the UPF0109 family
HMECEDPK_00128 2.1e-238 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
HMECEDPK_00129 0.0 ydaO E amino acid
HMECEDPK_00130 1e-99 folE 3.5.4.16 F gtp cyclohydrolase
HMECEDPK_00131 7e-147 folP 2.5.1.15, 2.7.6.3 H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HMECEDPK_00132 6e-298 amy 3.2.1.1 GH13 G Belongs to the glycosyl hydrolase 13 family
HMECEDPK_00133 1.2e-61 folB 1.13.11.81, 2.5.1.15, 2.7.6.3, 4.1.2.25, 5.1.99.8 H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HMECEDPK_00134 2.9e-87 folK 2.7.6.3, 4.1.2.25 H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HMECEDPK_00135 2.3e-170 murB 1.3.1.98 M cell wall formation
HMECEDPK_00136 1.2e-213 potA 3.6.3.30, 3.6.3.31 P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
HMECEDPK_00137 3.7e-140 potB P ABC-type spermidine putrescine transport system, permease component I
HMECEDPK_00138 3e-134 potC P ABC-type spermidine putrescine transport system, permease component II
HMECEDPK_00139 2.3e-206 potD P spermidine putrescine ABC transporter
HMECEDPK_00140 1.3e-19 XK27_08050 O HflC and HflK could regulate a protease
HMECEDPK_00141 9.6e-26 XK27_08050 O HflC and HflK could regulate a protease
HMECEDPK_00142 6.6e-62 XK27_08050 O stress-induced mitochondrial fusion
HMECEDPK_00143 8.1e-72 gloA 4.4.1.5 E Lactoylglutathione lyase
HMECEDPK_00144 5.1e-96 GK ROK family
HMECEDPK_00145 1.3e-209 serC 2.6.1.52 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HMECEDPK_00146 1.3e-104 wecD M Acetyltransferase (GNAT) domain
HMECEDPK_00147 7e-220 serA 1.1.1.399, 1.1.1.95 EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HMECEDPK_00148 6.3e-57 ogt 2.1.1.63, 3.2.2.20 L methylated-DNA-[protein]-cysteine S-methyltransferase activity
HMECEDPK_00149 6.4e-60 arsC 1.20.4.1 P Belongs to the ArsC family
HMECEDPK_00151 7.7e-56 lrgA S Effector of murein hydrolase LrgA
HMECEDPK_00152 2.2e-117 lrgB M effector of murein hydrolase
HMECEDPK_00153 2.6e-109 3.1.3.18 S IA, variant 1
HMECEDPK_00154 0.0 gyrB 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HMECEDPK_00155 1.6e-297 ezrA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HMECEDPK_00156 6.7e-116 serB 3.1.3.3 E phosphoserine phosphatase
HMECEDPK_00157 0.0 cas9 L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
HMECEDPK_00158 1.5e-163 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HMECEDPK_00159 3.5e-52 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HMECEDPK_00160 5.6e-110 csn2 S CRISPR-associated protein (Cas_Csn2)
HMECEDPK_00162 1.7e-154 EG Permeases of the drug metabolite transporter (DMT) superfamily
HMECEDPK_00164 6.6e-30 ycaO O OsmC-like protein
HMECEDPK_00165 5.5e-65 paaI Q protein possibly involved in aromatic compounds catabolism
HMECEDPK_00168 6.2e-134 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
HMECEDPK_00170 1.4e-248 obg S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HMECEDPK_00171 1.1e-16 XK27_00735
HMECEDPK_00172 6e-137 glnQ 3.6.3.21 E abc transporter atp-binding protein
HMECEDPK_00173 0.0 glnP P ABC-type amino acid transport signal transduction systems periplasmic component domain
HMECEDPK_00174 7.6e-32 S CAAX amino terminal protease family protein
HMECEDPK_00175 2e-78 S CAAX amino terminal protease family protein
HMECEDPK_00177 0.0 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
HMECEDPK_00178 2.9e-84 mutT 3.6.1.55 F Nudix family
HMECEDPK_00179 3.7e-143 ET Belongs to the bacterial solute-binding protein 3 family
HMECEDPK_00180 9.4e-136 ET ABC transporter
HMECEDPK_00181 2.1e-202 arcT 2.6.1.1 E Aminotransferase
HMECEDPK_00182 1.1e-136 gltS ET Belongs to the bacterial solute-binding protein 3 family
HMECEDPK_00183 5.5e-20 rpsU J Belongs to the bacterial ribosomal protein bS21 family
HMECEDPK_00184 0.0 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
HMECEDPK_00185 1.1e-201 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
HMECEDPK_00186 3.4e-55 yitW K metal-sulfur cluster biosynthetic enzyme
HMECEDPK_00187 1.7e-173 yfdH GT2 M COG0463, glycosyltransferases involved in cell wall biogenesis
HMECEDPK_00188 2e-236 S Predicted membrane protein (DUF2142)
HMECEDPK_00189 2.6e-160 rfbD 1.1.1.133, 5.1.3.13 M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
HMECEDPK_00190 9.4e-223 amrA S membrane protein involved in the export of O-antigen and teichoic acid
HMECEDPK_00191 1e-184 S Glycosyltransferase like family 2
HMECEDPK_00192 9.5e-183 cpsIaJ S Glycosyltransferase like family 2
HMECEDPK_00193 6.9e-130 arnC M group 2 family protein
HMECEDPK_00194 4.6e-42 S Uncharacterized conserved protein (DUF2304)
HMECEDPK_00195 2.4e-152 2.4.1.60 S Glycosyltransferase group 2 family protein
HMECEDPK_00196 2.3e-228 rgpA GT4 M Domain of unknown function (DUF1972)
HMECEDPK_00197 6.4e-176 rgpB GT2 M Glycosyltransferase, group 2 family protein
HMECEDPK_00198 1.8e-142 rgpC GM Transport permease protein
HMECEDPK_00199 6.4e-229 rgpD 3.6.3.38 P Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system
HMECEDPK_00200 4.5e-305 GT4 M transferase activity, transferring glycosyl groups
HMECEDPK_00201 0.0 rgpF M Rhamnan synthesis protein F
HMECEDPK_00202 1.7e-268 M Psort location CytoplasmicMembrane, score
HMECEDPK_00203 1.2e-115 radC E Belongs to the UPF0758 family
HMECEDPK_00204 4.8e-128 puuD T peptidase C26
HMECEDPK_00205 1.1e-116 rex K Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HMECEDPK_00206 3.1e-59 XK27_04120 S Putative amino acid metabolism
HMECEDPK_00207 1.2e-205 iscS 2.8.1.7 E Cysteine desulfurase
HMECEDPK_00208 1.2e-177 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HMECEDPK_00209 1.5e-103 yjbK S Adenylate cyclase
HMECEDPK_00210 5.5e-121 yjbM 2.7.6.5 S Gtp pyrophosphokinase
HMECEDPK_00211 5.4e-150 nadK 2.7.1.23 H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HMECEDPK_00212 8.3e-173 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 J Responsible for synthesis of pseudouridine from uracil
HMECEDPK_00213 3.1e-181 pta 2.3.1.8, 3.6.3.21 C phosphate acetyltransferase
HMECEDPK_00214 1.9e-78 L Transposase
HMECEDPK_00215 2.1e-85 L Integrase core domain protein
HMECEDPK_00216 6.7e-218 oxlT P COG0477 Permeases of the major facilitator superfamily
HMECEDPK_00217 8.9e-40 tatD L Hydrolase, tatd
HMECEDPK_00218 3.5e-24 oppF P Belongs to the ABC transporter superfamily
HMECEDPK_00219 1.2e-24 oppF P Belongs to the ABC transporter superfamily
HMECEDPK_00220 0.0 amiA E ABC transporter, substrate-binding protein, family 5
HMECEDPK_00221 1.1e-270 amiC P ABC transporter (Permease
HMECEDPK_00222 2.4e-167 amiD P ABC transporter (Permease
HMECEDPK_00223 6.4e-204 oppD P Belongs to the ABC transporter superfamily
HMECEDPK_00224 3.6e-171 oppF P Belongs to the ABC transporter superfamily
HMECEDPK_00225 5.6e-133 V ATPase activity
HMECEDPK_00226 4.9e-120 skfE V abc transporter atp-binding protein
HMECEDPK_00227 8.6e-63 yvoA_1 K Transcriptional
HMECEDPK_00228 8.2e-148 supH S overlaps another CDS with the same product name
HMECEDPK_00229 5.3e-150 XK27_02985 S overlaps another CDS with the same product name
HMECEDPK_00230 6.7e-214 ftsY U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HMECEDPK_00231 2e-112 gmk 2.7.4.8 F Essential for recycling GMP and indirectly, cGMP
HMECEDPK_00232 2.7e-46 rpoZ 2.7.7.6 K DNA-directed 5'-3' RNA polymerase activity
HMECEDPK_00233 0.0 priA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HMECEDPK_00234 2.5e-172 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HMECEDPK_00235 4.4e-247 sun 2.1.1.176 J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HMECEDPK_00236 2e-132 stp 3.1.3.16 T phosphatase
HMECEDPK_00237 0.0 prkC 2.7.11.1 KLT serine threonine protein kinase
HMECEDPK_00238 3.7e-120 yvqF KT membrane
HMECEDPK_00239 5.8e-175 vraS 2.7.13.3 T Histidine kinase
HMECEDPK_00240 2.2e-114 vraR K Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HMECEDPK_00243 5.8e-94 rimM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HMECEDPK_00244 1.4e-135 trmD 2.1.1.228, 4.6.1.12 J Belongs to the RNA methyltransferase TrmD family
HMECEDPK_00245 5.9e-188 trxB1 1.18.1.2, 1.19.1.1 C Ferredoxin--NADP reductase
HMECEDPK_00246 0.0 ftsK D Belongs to the FtsK SpoIIIE SftA family
HMECEDPK_00247 1.7e-120 pulA 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
HMECEDPK_00248 1.8e-33 pulA 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
HMECEDPK_00249 7e-150 pulA 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
HMECEDPK_00250 6.4e-62 L Transposase
HMECEDPK_00251 0.0 gshF 6.3.2.2, 6.3.2.29, 6.3.2.30, 6.3.2.4 H Belongs to the glutamate--cysteine ligase type 1 family
HMECEDPK_00252 4.3e-40 V abc transporter atp-binding protein
HMECEDPK_00253 2.5e-101 V abc transporter atp-binding protein
HMECEDPK_00254 6.7e-17 rtxA M M26 IgA1-specific Metallo-endopeptidase C-terminal region
HMECEDPK_00255 3.5e-228 zmpB M M26 IgA1-specific Metallo-endopeptidase C-terminal region
HMECEDPK_00256 1.2e-25 L transposition
HMECEDPK_00257 2.7e-08 L Integrase core domain protein
HMECEDPK_00258 2.3e-184 galR K Transcriptional regulator
HMECEDPK_00259 1.8e-220 galK 2.7.1.6 G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HMECEDPK_00260 8e-290 galT 2.7.7.12 G UDPglucose--hexose-1-phosphate uridylyltransferase
HMECEDPK_00261 6.6e-195 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
HMECEDPK_00262 2.6e-202 galM 5.1.3.3 G Catalyzes the interconversion of alpha and beta anomers of maltose
HMECEDPK_00263 0.0 lacS G transporter
HMECEDPK_00264 0.0 lacL 3.2.1.23 G -beta-galactosidase
HMECEDPK_00265 2e-230 sbcD L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
HMECEDPK_00266 0.0 sbcC L ATPase involved in DNA repair
HMECEDPK_00267 2.8e-85
HMECEDPK_00269 1.8e-87 L transposase activity
HMECEDPK_00270 1.4e-150 L Integrase core domain protein
HMECEDPK_00271 6.5e-159 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
HMECEDPK_00273 5.5e-258 I radical SAM domain protein
HMECEDPK_00274 1.2e-176 EGP Major Facilitator Superfamily
HMECEDPK_00275 1.5e-109 C Fe-S oxidoreductases
HMECEDPK_00277 1.1e-151 V MatE
HMECEDPK_00278 1e-13 rpmH J Ribosomal protein L34
HMECEDPK_00279 2e-186 jag S RNA-binding protein
HMECEDPK_00280 7.5e-141 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HMECEDPK_00281 5.9e-55 rnpA 3.1.26.5 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
HMECEDPK_00282 4.1e-264 argH 4.3.2.1 E Argininosuccinate lyase
HMECEDPK_00283 2e-230 argG 6.3.4.5 E Belongs to the argininosuccinate synthase family. Type 1 subfamily
HMECEDPK_00284 2.1e-282 gltX 6.1.1.17, 6.1.1.24 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HMECEDPK_00285 7.4e-80 amiA E transmembrane transport
HMECEDPK_00286 7.3e-69 amiA E transmembrane transport
HMECEDPK_00287 4.8e-120 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
HMECEDPK_00288 3.7e-70 rplK J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HMECEDPK_00289 9.2e-51 S Protein of unknown function (DUF3397)
HMECEDPK_00290 2.3e-87 cah 4.2.1.1 P Reversible hydration of carbon dioxide
HMECEDPK_00291 1.1e-57 WQ51_05710 S Mitochondrial biogenesis AIM24
HMECEDPK_00292 6.2e-12 WQ51_05710 S Mitochondrial biogenesis AIM24
HMECEDPK_00293 1.4e-226 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HMECEDPK_00294 1.1e-80 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
HMECEDPK_00295 1.8e-19 XK27_09620 S FMN reductase (NADPH) activity
HMECEDPK_00296 4.3e-77 XK27_09620 S reductase
HMECEDPK_00297 2.1e-32 XK27_09615 S FMN reductase (NADPH) activity
HMECEDPK_00298 3.1e-115 XK27_09615 C reductase
HMECEDPK_00299 1.6e-61 fnt P Formate nitrite transporter
HMECEDPK_00300 5.5e-64 XK27_08585 S Psort location CytoplasmicMembrane, score
HMECEDPK_00301 2e-186 gpsA 1.1.1.94 I Glycerol-3-phosphate dehydrogenase
HMECEDPK_00302 5.1e-170 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
HMECEDPK_00303 5.2e-119 gluP 3.4.21.105 O membrane protein (homolog of Drosophila rhomboid)
HMECEDPK_00304 9.1e-95 ygfA 6.3.3.2 H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HMECEDPK_00305 7.9e-221 hipO 3.5.1.47 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
HMECEDPK_00306 8.1e-59 dapD 2.3.1.117, 2.3.1.89 E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
HMECEDPK_00307 2.7e-48 S glycolate biosynthetic process
HMECEDPK_00308 3.4e-64 S phosphatase activity
HMECEDPK_00309 6.3e-159 rrmA 2.1.1.187 Q methyltransferase
HMECEDPK_00312 1.2e-91 tadA 3.5.4.1, 3.5.4.33 FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
HMECEDPK_00313 5.1e-66 ssb_2 L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
HMECEDPK_00314 4.1e-36 yeeD O sulfur carrier activity
HMECEDPK_00315 1.3e-190 yeeE S Sulphur transport
HMECEDPK_00316 7.9e-114 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HMECEDPK_00317 4.2e-55 ytpP 2.7.1.180, 5.3.4.1 CO Thioredoxin
HMECEDPK_00318 4.1e-09 S Domain of unknown function (DUF4651)
HMECEDPK_00319 2e-205 pepA 3.4.11.7 G COG1363 Cellulase M and related proteins
HMECEDPK_00320 1.5e-130 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HMECEDPK_00321 1.8e-111 S CAAX amino terminal protease family protein
HMECEDPK_00323 5e-67 V CAAX protease self-immunity
HMECEDPK_00324 1.4e-33 V CAAX protease self-immunity
HMECEDPK_00326 2.9e-221 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HMECEDPK_00327 5.9e-177 ytxK 2.1.1.72 L DNA methylase
HMECEDPK_00328 2e-12 comGF U Putative Competence protein ComGF
HMECEDPK_00329 1.5e-71 comGF U Competence protein ComGF
HMECEDPK_00330 1.4e-15 NU Type II secretory pathway pseudopilin
HMECEDPK_00331 1.8e-57 cglD NU Competence protein
HMECEDPK_00332 8.5e-43 comGC U Required for transformation and DNA binding
HMECEDPK_00333 3e-145 cglB NU type II secretion system
HMECEDPK_00334 1.9e-175 comGA NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HMECEDPK_00335 2.9e-68 S cog cog4699
HMECEDPK_00336 0.0 rpoC 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HMECEDPK_00337 0.0 rpoB 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HMECEDPK_00338 0.0 pbp1B 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
HMECEDPK_00339 1.2e-238 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HMECEDPK_00340 1.6e-196 ilvC 1.1.1.86 H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HMECEDPK_00341 7.7e-77 ilvN 2.2.1.6 E Acetolactate synthase
HMECEDPK_00342 0.0 ilvB 2.2.1.6 EH Acetolactate synthase
HMECEDPK_00343 8.8e-281 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
HMECEDPK_00344 8.4e-09 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
HMECEDPK_00345 1.7e-304 yloV S kinase related to dihydroxyacetone kinase
HMECEDPK_00346 1.4e-57 asp S cog cog1302
HMECEDPK_00347 9.3e-226 norN V Mate efflux family protein
HMECEDPK_00348 2.4e-278 thrC 4.2.3.1 E Threonine synthase
HMECEDPK_00349 5.5e-65 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
HMECEDPK_00350 8e-35 adhE 1.1.1.1, 1.2.1.10 C hydroxyacid-oxoacid transhydrogenase activity
HMECEDPK_00351 3.3e-65 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
HMECEDPK_00352 6.3e-132 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
HMECEDPK_00353 1.4e-63 adhE 1.1.1.1, 1.2.1.10 C Dehydrogenase
HMECEDPK_00354 0.0 pepO 3.4.24.71 O Peptidase family M13
HMECEDPK_00355 2.8e-38 treC 3.2.1.93 GH13 G COG0366 Glycosidases
HMECEDPK_00356 1.2e-69 treC 3.2.1.93 GH13 G COG0366 Glycosidases
HMECEDPK_00357 5.9e-66 treC 3.2.1.93 GH13 G COG0366 Glycosidases
HMECEDPK_00358 1.4e-54 treB 2.7.1.201 G PTS System
HMECEDPK_00359 5.8e-21 treR K DNA-binding transcription factor activity
HMECEDPK_00360 1.2e-85 treR K trehalose operon
HMECEDPK_00361 3.3e-95 ywlG S Belongs to the UPF0340 family
HMECEDPK_00364 4.1e-287 groL O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
HMECEDPK_00365 1.3e-42 groS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HMECEDPK_00366 5.2e-142 cmpC S abc transporter atp-binding protein
HMECEDPK_00367 0.0 WQ51_06230 S ABC transporter substrate binding protein
HMECEDPK_00368 0.0 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
HMECEDPK_00369 1.4e-231 rseP 3.4.21.107, 3.4.21.116 M zinc metalloprotease
HMECEDPK_00370 2.2e-145 cdsA 2.7.7.41 S Belongs to the CDS family
HMECEDPK_00371 1.1e-141 uppS 2.5.1.31 H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HMECEDPK_00372 9.8e-50 yajC U protein transport
HMECEDPK_00373 1.9e-127 yeeN K transcriptional regulatory protein
HMECEDPK_00374 2.8e-257 pgi 5.3.1.9 G Belongs to the GPI family
HMECEDPK_00375 6.8e-158 rgfB 3.1.3.90 L Endonuclease/Exonuclease/phosphatase family
HMECEDPK_00376 1.6e-106 ptsG 2.7.1.199, 2.7.1.208, 2.7.1.211 G phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1
HMECEDPK_00377 2.1e-150 ptsG 2.7.1.199, 2.7.1.208, 2.7.1.211 G pts system
HMECEDPK_00378 5.6e-65 ptsG 2.7.1.199, 2.7.1.208 G pts system
HMECEDPK_00379 1.4e-162 mleP2 S Transporter, auxin efflux carrier (AEC) family protein
HMECEDPK_00380 2.5e-128 adcB P ABC transporter (Permease
HMECEDPK_00381 6.4e-136 adcC P ABC transporter, ATP-binding protein
HMECEDPK_00382 3.1e-72 adcR K transcriptional
HMECEDPK_00383 1.9e-223 EGP Major facilitator Superfamily
HMECEDPK_00384 7.4e-183 dus J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HMECEDPK_00385 1.9e-158 hslO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HMECEDPK_00388 9e-170 oppF P Belongs to the ABC transporter superfamily
HMECEDPK_00389 3.1e-43 oppD P Belongs to the ABC transporter superfamily
HMECEDPK_00390 1.7e-61 oppD P Belongs to the ABC transporter superfamily
HMECEDPK_00391 2.5e-32 oppD P Belongs to the ABC transporter superfamily
HMECEDPK_00392 3e-27 oppD P Belongs to the ABC transporter superfamily
HMECEDPK_00393 1.4e-38 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMECEDPK_00394 7.3e-74 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMECEDPK_00395 6.6e-11 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMECEDPK_00396 4.2e-27 oppB P ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMECEDPK_00397 2e-138 oppA E ABC transporter substrate-binding protein
HMECEDPK_00398 7e-10 oppA E ABC transporter substrate-binding protein
HMECEDPK_00399 3.5e-274 sufB O assembly protein SufB
HMECEDPK_00400 1.1e-74 nifU C SUF system FeS assembly protein, NifU family
HMECEDPK_00401 1e-237 sufS 2.8.1.7, 4.4.1.16 E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HMECEDPK_00402 6.3e-235 sufD O assembly protein SufD
HMECEDPK_00403 9.5e-144 sufC O ABC-type transport system involved in Fe-S cluster assembly, ATPase component
HMECEDPK_00404 1.1e-185 tagO 2.7.8.33, 2.7.8.35 M transferase
HMECEDPK_00405 2.3e-136 mecA NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
HMECEDPK_00406 9.1e-153 uppP 3.6.1.27 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
HMECEDPK_00407 1.8e-276 glnP P ABC transporter
HMECEDPK_00408 1e-123 glnQ E abc transporter atp-binding protein
HMECEDPK_00410 5e-94 V VanZ like family
HMECEDPK_00411 9.2e-43 rpsO J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HMECEDPK_00412 6.5e-202 yhjX P Major Facilitator
HMECEDPK_00413 5.3e-113 fnr5 K Catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
HMECEDPK_00414 3.3e-112 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
HMECEDPK_00415 1.7e-237 ilvA 4.3.1.19 E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HMECEDPK_00416 1.9e-45 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
HMECEDPK_00417 2.1e-58 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
HMECEDPK_00418 2e-27 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
HMECEDPK_00419 1.4e-09 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
HMECEDPK_00420 2.3e-75 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
HMECEDPK_00421 0.0 relA 2.7.6.5 KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HMECEDPK_00422 2.4e-83 nrdI F Belongs to the NrdI family
HMECEDPK_00423 0.0 cpdB 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
HMECEDPK_00424 4.4e-135 rsmE 2.1.1.193 J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
HMECEDPK_00425 3.7e-179 prmA J Ribosomal protein L11 methyltransferase
HMECEDPK_00426 3.7e-81 mutT3 3.6.1.13, 3.6.1.55 L NUDIX domain
HMECEDPK_00427 1.3e-84 XK27_03960 S Protein of unknown function (DUF3013)
HMECEDPK_00428 7.6e-310 pyrG 6.3.4.2 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
HMECEDPK_00429 4.8e-73 rpoE K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
HMECEDPK_00430 6.4e-219 tig D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
HMECEDPK_00431 6.6e-148 ykuT M mechanosensitive ion channel
HMECEDPK_00432 1.6e-77 sigH K DNA-templated transcription, initiation
HMECEDPK_00433 6.5e-87
HMECEDPK_00434 1.5e-233 cfa 2.1.1.317, 2.1.1.79 M cyclopropane-fatty-acyl-phospholipid synthase
HMECEDPK_00435 1.8e-56 amd 3.5.1.47 E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
HMECEDPK_00436 9.9e-19 S Domain of unknown function (DUF4649)
HMECEDPK_00438 5.5e-139 mreC M Involved in formation and maintenance of cell shape
HMECEDPK_00439 6.3e-88 mreD M Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HMECEDPK_00440 1.7e-90 usp 3.5.1.28 CBM50 S CHAP domain
HMECEDPK_00441 1.2e-174 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HMECEDPK_00442 2.9e-218 araT 2.6.1.1 E Aminotransferase
HMECEDPK_00443 7e-144 recO L Involved in DNA repair and RecF pathway recombination
HMECEDPK_00444 1.1e-176 plsX 2.3.1.15 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
HMECEDPK_00445 9.3e-34 acpP1 IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
HMECEDPK_00446 9.9e-129 purC 4.1.1.21, 4.3.2.2, 6.3.2.6 F Belongs to the SAICAR synthetase family
HMECEDPK_00447 0.0 purL 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HMECEDPK_00448 3.8e-276 purF 2.4.2.14 F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HMECEDPK_00449 4.8e-185 purM 6.3.3.1, 6.3.4.13 F Phosphoribosylformylglycinamidine cyclo-ligase
HMECEDPK_00450 1.4e-101 purN 2.1.2.2 F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HMECEDPK_00451 2.5e-294 purH 2.1.2.3, 3.5.4.10 F Bifunctional purine biosynthesis protein PurH
HMECEDPK_00452 1e-90 L transposase activity
HMECEDPK_00453 3.5e-50 L transposition
HMECEDPK_00454 2e-32 L Integrase core domain protein
HMECEDPK_00455 2.3e-161 S CHAP domain
HMECEDPK_00456 3.4e-241 purD 6.3.4.13 F Belongs to the GARS family
HMECEDPK_00457 4.9e-76 purE 5.4.99.18 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HMECEDPK_00458 2.2e-204 purK 6.3.4.18 F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HMECEDPK_00459 9.2e-141 1.1.1.169 H Ketopantoate reductase
HMECEDPK_00460 8.7e-248 purB 4.3.2.2 F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HMECEDPK_00461 0.0 argS 6.1.1.19 J Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
HMECEDPK_00462 8.2e-70 argR K Regulates arginine biosynthesis genes
HMECEDPK_00463 1.5e-56 ymcA 3.6.3.21 S Belongs to the UPF0342 family
HMECEDPK_00464 0.0 mutS L that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HMECEDPK_00465 7e-34 S Protein of unknown function (DUF3021)
HMECEDPK_00466 1.2e-61 KT phosphorelay signal transduction system
HMECEDPK_00468 0.0 mutL L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HMECEDPK_00470 7.8e-103 ruvA 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
HMECEDPK_00471 1.9e-106 tag 3.2.2.20 L 3-methyladenine DNA glycosylase
HMECEDPK_00472 3.2e-231 cinA 3.5.1.42 S Belongs to the CinA family
HMECEDPK_00473 4.7e-205 recA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HMECEDPK_00474 2.3e-66 spxA_2 1.20.4.1 P Belongs to the ArsC family
HMECEDPK_00475 2.1e-94 hpf J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HMECEDPK_00476 4.4e-123 comFC S Competence protein
HMECEDPK_00477 1.8e-253 comFA L Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HMECEDPK_00478 6.3e-111 yvyE 3.4.13.9 S YigZ family
HMECEDPK_00479 2.2e-168 cysK 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
HMECEDPK_00480 3.3e-43 acuB S IMP dehydrogenase activity
HMECEDPK_00481 2.8e-70 acuB S IMP dehydrogenase activity
HMECEDPK_00482 9.6e-124 livF E COG0410 ABC-type branched-chain amino acid transport systems, ATPase component
HMECEDPK_00483 9.6e-138 livG E COG0411 ABC-type branched-chain amino acid transport systems, ATPase component
HMECEDPK_00484 1.4e-138 livM E Belongs to the binding-protein-dependent transport system permease family
HMECEDPK_00485 1.9e-145 livH E Belongs to the binding-protein-dependent transport system permease family
HMECEDPK_00486 1.1e-212 livJ E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component
HMECEDPK_00487 7.1e-46 ylbG S UPF0298 protein
HMECEDPK_00488 3.4e-74 ylbF S Belongs to the UPF0342 family
HMECEDPK_00489 2.9e-105 clpP 3.4.21.92 OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
HMECEDPK_00490 4.4e-112 upp 2.4.2.9 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HMECEDPK_00493 1e-223 malY 4.4.1.8 E COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
HMECEDPK_00494 1e-201 metB 2.5.1.48, 4.4.1.8 E cystathionine
HMECEDPK_00495 3.3e-96 pacL 3.6.3.8, 3.6.3.9 P cation transport ATPase
HMECEDPK_00496 4.5e-283 ytgP S Membrane protein involved in the export of O-antigen and teichoic acid
HMECEDPK_00497 1.4e-275 murE 6.3.2.13, 6.3.2.7 M to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HMECEDPK_00498 2.1e-213 femA 2.3.2.10, 2.3.2.16, 2.3.2.17, 2.3.2.18 V protein involved in methicillin resistance
HMECEDPK_00500 3.4e-37 yvdD 3.2.2.10 L Belongs to the LOG family
HMECEDPK_00501 2e-22 yvdD 3.2.2.10 S Belongs to the LOG family
HMECEDPK_00502 1.7e-57 rbfA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HMECEDPK_00503 0.0 infB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HMECEDPK_00504 1.4e-41 ylxQ J ribosomal protein
HMECEDPK_00505 1e-47 ylxR K Nucleic-acid-binding protein implicated in transcription termination
HMECEDPK_00506 3.1e-212 nusA K Participates in both transcription termination and antitermination
HMECEDPK_00507 3.9e-81 rimP S Required for maturation of 30S ribosomal subunits
HMECEDPK_00508 2.5e-220 brpA K Transcriptional
HMECEDPK_00509 2.4e-92 XK27_05885 2.3.1.82 M Acetyltransferase GNAT Family
HMECEDPK_00510 1.4e-77 ydiB 2.7.1.221, 5.1.1.1 M ATPase or kinase
HMECEDPK_00511 1.9e-248 pbuO S permease
HMECEDPK_00512 1e-153 yitU 3.1.3.104 S hydrolases of the HAD superfamily
HMECEDPK_00513 1.5e-140 XK27_00940 1.2.1.70, 3.5.1.9 S Metal-dependent hydrolase
HMECEDPK_00514 1.1e-181 manL 2.7.1.191 G pts system
HMECEDPK_00515 1.7e-116 manM G pts system
HMECEDPK_00516 6.2e-168 manN G PTS system mannose fructose sorbose family IID component
HMECEDPK_00517 6.5e-63 manO S protein conserved in bacteria
HMECEDPK_00518 1.1e-231 serS 6.1.1.11 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HMECEDPK_00519 3e-133 budA 4.1.1.5 H Belongs to the alpha-acetolactate decarboxylase family
HMECEDPK_00520 0.0 alsS 2.2.1.6 EH Belongs to the TPP enzyme family
HMECEDPK_00521 6.6e-61 EGP Major facilitator Superfamily
HMECEDPK_00522 3.9e-136 speB 3.5.3.11 E hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
HMECEDPK_00523 1.1e-212 pqqE C radical SAM domain protein
HMECEDPK_00526 1.8e-156 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
HMECEDPK_00527 0.0 lepA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
HMECEDPK_00528 3.9e-19 IQ Acetoin reductase
HMECEDPK_00529 6e-43 IQ Acetoin reductase
HMECEDPK_00530 2.7e-48 pspE P Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HMECEDPK_00531 1.7e-75 ndk 2.7.4.6 F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
HMECEDPK_00532 4.2e-152 XK27_05470 E Methionine synthase
HMECEDPK_00533 6.6e-259 trmFO 2.1.1.74 J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HMECEDPK_00534 1.3e-252 T PhoQ Sensor
HMECEDPK_00535 2.2e-122 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HMECEDPK_00536 1.4e-150 S TraX protein
HMECEDPK_00537 0.0 topA 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HMECEDPK_00538 3.2e-158 dprA LU DNA protecting protein DprA
HMECEDPK_00539 4.1e-167 GK ROK family
HMECEDPK_00540 2e-135 rnhB 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HMECEDPK_00541 1.1e-158 ylqF S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HMECEDPK_00542 1.6e-128 K DNA-binding helix-turn-helix protein
HMECEDPK_00543 2e-45 niaR S small molecule binding protein (contains 3H domain)
HMECEDPK_00544 1e-17 niaR S small molecule binding protein (contains 3H domain)
HMECEDPK_00545 3.1e-87 niaX
HMECEDPK_00546 1.4e-273 ffh 3.6.5.4 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HMECEDPK_00547 1.1e-53 ylxM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HMECEDPK_00548 2e-126 gntR1 K transcriptional
HMECEDPK_00549 3.9e-303 guaA 2.3.1.128, 6.3.5.2 F Catalyzes the synthesis of GMP from XMP
HMECEDPK_00550 0.0 sthIM 2.1.1.72 L Adenine specific DNA methylase Mod
HMECEDPK_00551 2.1e-30 rpsT J rRNA binding
HMECEDPK_00552 1.9e-172 coaA 2.7.1.33 F Pantothenic acid kinase
HMECEDPK_00553 1.8e-107 rsmC 2.1.1.172 J Methyltransferase small domain protein
HMECEDPK_00554 1.2e-57 pdp 2.4.2.2, 2.4.2.4 F Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate
HMECEDPK_00555 1.3e-97 pdp 2.4.2.2, 2.4.2.4 F Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate
HMECEDPK_00556 1.4e-22 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HMECEDPK_00557 4e-63 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HMECEDPK_00558 1.3e-69 cdd 2.4.2.2, 3.5.4.5 F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
HMECEDPK_00559 9.5e-192 tcsA S ABC-type transport system, periplasmic component surface lipoprotein
HMECEDPK_00560 3.7e-282 xylG 3.6.3.17 S ABC transporter, ATP-binding protein
HMECEDPK_00561 3e-190 yufP S Belongs to the binding-protein-dependent transport system permease family
HMECEDPK_00562 4.8e-171 yufQ S Belongs to the binding-protein-dependent transport system permease family
HMECEDPK_00563 1.2e-120 ycbL 3.1.2.6 S COG0491 Zn-dependent hydrolases, including glyoxylases
HMECEDPK_00564 0.0 dinG 2.7.7.7, 3.6.4.12 L helicase involved in DNA repair and perhaps also replication
HMECEDPK_00565 6.8e-81 ypmB S Protein conserved in bacteria
HMECEDPK_00566 1.6e-216 aspB 2.6.1.1, 2.6.1.14 E Aminotransferase
HMECEDPK_00567 2.4e-261 asnS 6.1.1.22 J Catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
HMECEDPK_00568 1.5e-07
HMECEDPK_00569 3e-13
HMECEDPK_00570 3e-63 tdcF 3.5.99.10 J endoribonuclease L-PSP
HMECEDPK_00571 1.5e-123 queC 6.3.4.20 F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HMECEDPK_00572 3.7e-81 queD 4.1.2.50, 4.2.3.12 H synthase
HMECEDPK_00573 4.6e-134 queE 1.97.1.4, 4.3.99.3 H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
HMECEDPK_00574 6.5e-95 queF 1.7.1.13 S Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily
HMECEDPK_00575 2.2e-19 D nuclear chromosome segregation
HMECEDPK_00576 2e-135 yejC S cyclic nucleotide-binding protein
HMECEDPK_00577 1.2e-163 rapZ S Displays ATPase and GTPase activities
HMECEDPK_00578 3.6e-182 ybhK S Required for morphogenesis under gluconeogenic growth conditions
HMECEDPK_00579 8.7e-162 whiA K May be required for sporulation
HMECEDPK_00580 2.1e-185 pepD E Dipeptidase
HMECEDPK_00581 5.4e-32 cspD K Cold shock protein domain
HMECEDPK_00582 8e-42 K Cold-Shock Protein
HMECEDPK_00583 0.0 res_1 3.1.21.5 S Type III restriction
HMECEDPK_00584 8.8e-21
HMECEDPK_00585 4.2e-113 adhP 1.1.1.1 C alcohol dehydrogenase
HMECEDPK_00586 8e-58 adhP 1.1.1.1 C alcohol dehydrogenase
HMECEDPK_00587 7.4e-144 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HMECEDPK_00588 1.2e-157 aatB ET ABC transporter substrate-binding protein
HMECEDPK_00589 1.5e-112 glnQ 3.6.3.21 E abc transporter atp-binding protein
HMECEDPK_00590 4e-105 artQ P ABC transporter (Permease
HMECEDPK_00591 2.5e-58 phnA P Alkylphosphonate utilization operon protein PhnA
HMECEDPK_00592 0.0 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
HMECEDPK_00593 4.5e-166 cpsY K Transcriptional regulator
HMECEDPK_00594 4.3e-70 L transposition
HMECEDPK_00595 1.6e-19 L transposase activity
HMECEDPK_00596 3e-117 mur1 NU muramidase
HMECEDPK_00597 1.1e-170 yeiH S Membrane
HMECEDPK_00599 1.7e-08
HMECEDPK_00600 4e-292 adcA P Belongs to the bacterial solute-binding protein 9 family
HMECEDPK_00601 1.3e-88 XK27_10720 D peptidase activity
HMECEDPK_00602 1.2e-79 hsdM 2.1.1.72 V HsdM N-terminal domain
HMECEDPK_00603 1.1e-08 mycA 4.2.1.53 S Myosin-crossreactive antigen
HMECEDPK_00604 1.2e-155 glcU U Glucose uptake
HMECEDPK_00605 1.7e-111 hsdM 2.1.1.72 V type I restriction-modification system
HMECEDPK_00606 3.7e-54 hsdS 2.1.1.72, 3.1.21.3 V type I restriction modification DNA specificity domain
HMECEDPK_00607 3.7e-226 sthIM 2.1.1.72 L DNA methylase
HMECEDPK_00610 5.3e-18 D FtsK/SpoIIIE family
HMECEDPK_00611 1.3e-134 D ftsk spoiiie
HMECEDPK_00613 1.3e-154
HMECEDPK_00614 1.7e-22
HMECEDPK_00615 9.3e-184 L Phage integrase family
HMECEDPK_00616 9.5e-65 rpsI J Belongs to the universal ribosomal protein uS9 family
HMECEDPK_00617 2e-79 rplM J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HMECEDPK_00618 2.3e-181 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HMECEDPK_00619 4.7e-32 K helix-turn-helix
HMECEDPK_00620 1.7e-154 degV S DegV family
HMECEDPK_00621 3.5e-91 yacP S RNA-binding protein containing a PIN domain
HMECEDPK_00622 5.7e-135 trmH 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HMECEDPK_00625 4.2e-68 mrnC J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HMECEDPK_00626 1.5e-258 cysS 6.1.1.16, 6.3.1.13 J Belongs to the class-I aminoacyl-tRNA synthetase family
HMECEDPK_00627 1.1e-112 cysE 2.3.1.30 E serine acetyltransferase
HMECEDPK_00628 1.3e-105 S SseB protein N-terminal domain
HMECEDPK_00629 0.0 pnp 2.7.7.8 J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
HMECEDPK_00630 4.2e-231 dacA 3.4.16.4 M Belongs to the peptidase S11 family
HMECEDPK_00631 1.7e-60 hmpT S membrane
HMECEDPK_00632 6.2e-137 thiD 2.7.1.35, 2.7.1.49, 2.7.4.7 H phosphomethylpyrimidine kinase
HMECEDPK_00633 2.5e-138 truA 5.4.99.12 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
HMECEDPK_00634 4.2e-190 dnaJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
HMECEDPK_00635 9.8e-298 dnaK O Heat shock 70 kDa protein
HMECEDPK_00636 1.3e-71 grpE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HMECEDPK_00637 5.3e-198 hrcA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
HMECEDPK_00638 1.3e-102 acmA 3.2.1.17 NU amidase activity
HMECEDPK_00639 1.6e-143 vanY 3.4.17.14 M D-alanyl-D-alanine carboxypeptidase
HMECEDPK_00640 2.2e-38 ais G alpha-ribazole phosphatase activity
HMECEDPK_00641 1.9e-242 XK27_08635 S UPF0210 protein
HMECEDPK_00642 3.6e-39 gcvR T UPF0237 protein
HMECEDPK_00643 3.7e-224 capA M Bacterial capsule synthesis protein
HMECEDPK_00644 2.9e-125 tnp L Transposase IS66 family
HMECEDPK_00645 6.9e-53 isp2 S pathogenesis
HMECEDPK_00647 2.4e-117
HMECEDPK_00649 2.2e-35 S Helix-turn-helix domain
HMECEDPK_00650 3.4e-83 int L Belongs to the 'phage' integrase family
HMECEDPK_00651 8.5e-112 int L Belongs to the 'phage' integrase family
HMECEDPK_00653 3.9e-299 res_1 3.1.21.5 S DEAD-like helicases superfamily
HMECEDPK_00654 1.8e-32 dacA 3.4.16.4 M Belongs to the peptidase S11 family
HMECEDPK_00655 3.2e-151 dacA 3.4.16.4 M Belongs to the peptidase S11 family
HMECEDPK_00656 0.0 clpC O Belongs to the ClpA ClpB family
HMECEDPK_00657 6.2e-76 ctsR K Belongs to the CtsR family
HMECEDPK_00658 1.1e-83 S Putative small multi-drug export protein
HMECEDPK_00659 1.7e-182 tsf J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HMECEDPK_00660 1.3e-137 rpsB J Belongs to the universal ribosomal protein uS2 family
HMECEDPK_00663 1.9e-86 yocD 3.4.17.13 V proteins, homologs of microcin C7 resistance protein MccF
HMECEDPK_00664 7.3e-22 yocD 3.4.17.13 V carboxypeptidase activity
HMECEDPK_00665 2.3e-38 L transposition
HMECEDPK_00666 1e-87 L Integrase core domain protein
HMECEDPK_00667 3.5e-97 S reductase
HMECEDPK_00668 2.6e-55 badR K DNA-binding transcription factor activity
HMECEDPK_00669 5.5e-36 XK27_02060 S Transglycosylase associated protein
HMECEDPK_00670 1.2e-235 pepS E COG2309 Leucyl aminopeptidase (aminopeptidase T)
HMECEDPK_00671 0.0 polC 2.7.7.7 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HMECEDPK_00676 1.9e-07
HMECEDPK_00677 1.2e-32 L Integrase core domain protein
HMECEDPK_00678 3.6e-230 dltD M Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HMECEDPK_00679 1.7e-35 dltC 6.1.1.13 IQ Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HMECEDPK_00680 3.9e-237 dltB M Membrane protein involved in D-alanine export
HMECEDPK_00681 1.4e-297 dltA 6.1.1.13 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HMECEDPK_00682 1.7e-09 S D-Ala-teichoic acid biosynthesis protein
HMECEDPK_00683 0.0 XK27_10035 V abc transporter atp-binding protein
HMECEDPK_00684 0.0 yfiB1 V abc transporter atp-binding protein
HMECEDPK_00685 6.6e-105 pvaA M lytic transglycosylase activity
HMECEDPK_00686 1.2e-177 ndpA S 37-kD nucleoid-associated bacterial protein
HMECEDPK_00687 1.8e-234 glyA 2.1.2.1 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HMECEDPK_00688 9.7e-109 ywlC 2.7.7.87, 3.1.3.48 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
HMECEDPK_00689 1.2e-154 prmB 2.1.1.297, 2.1.1.298 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
HMECEDPK_00690 3e-193 prfA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HMECEDPK_00691 2.4e-112 tdk 2.7.1.21 F thymidine kinase
HMECEDPK_00692 2.1e-188 add 3.5.4.4 F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HMECEDPK_00693 3.1e-155 gst O Glutathione S-transferase
HMECEDPK_00694 1e-184 nrnA 3.1.13.3, 3.1.3.7 S domain protein
HMECEDPK_00695 1.5e-177 apbE 2.7.1.180 H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
HMECEDPK_00696 2e-45 rpmE2 J 50S ribosomal protein L31
HMECEDPK_00697 1.4e-212 mntH P Mn2 and Fe2 transporters of the NRAMP family
HMECEDPK_00698 0.0 ileS 6.1.1.5 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HMECEDPK_00699 1.8e-135 divIVA D Cell division protein DivIVA
HMECEDPK_00700 1.2e-143 ylmH T S4 RNA-binding domain
HMECEDPK_00701 2.6e-34 yggT D integral membrane protein
HMECEDPK_00702 1.4e-96 sepF D cell septum assembly
HMECEDPK_00703 2.7e-123 ylmE S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HMECEDPK_00704 5.4e-237 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HMECEDPK_00705 8e-252 ftsA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
HMECEDPK_00706 1.1e-171 divIB D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
HMECEDPK_00707 1e-201 murG 2.4.1.227 GT28 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HMECEDPK_00708 4.6e-252 murD 6.3.2.9 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HMECEDPK_00710 0.0 typA T GTP-binding protein TypA
HMECEDPK_00711 2.2e-179 glk 2.7.1.2 G Glucokinase
HMECEDPK_00712 8.4e-28 yqgQ S protein conserved in bacteria
HMECEDPK_00713 1.1e-80 perR P Belongs to the Fur family
HMECEDPK_00714 3.5e-91 dps P Belongs to the Dps family
HMECEDPK_00715 2.2e-114 pilD 3.4.23.43 NOU Bacterial Peptidase A24 N-terminal domain
HMECEDPK_00716 2e-186 3.5.2.6 V D-alanyl-D-alanine carboxypeptidase
HMECEDPK_00717 8.5e-113 sodA 1.15.1.1 C radicals which are normally produced within the cells and which are toxic to biological systems
HMECEDPK_00718 1.2e-183 holA 2.7.7.7 L DNA polymerase III delta subunit
HMECEDPK_00719 0.0 ppc 4.1.1.31 H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HMECEDPK_00720 6.2e-56 S Domain of unknown function (DUF4430)
HMECEDPK_00721 4.2e-75 S Psort location CytoplasmicMembrane, score
HMECEDPK_00722 9.3e-132 htpX O Belongs to the peptidase M48B family
HMECEDPK_00723 1.7e-91 lemA S LemA family
HMECEDPK_00724 1.7e-174 spd F DNA RNA non-specific endonuclease
HMECEDPK_00725 3e-38
HMECEDPK_00727 5.9e-134 hsdS 3.1.21.3 V Type I restriction modification DNA specificity domain
HMECEDPK_00728 7.3e-289 hsdM 2.1.1.72 V N-6 DNA Methylase
HMECEDPK_00729 0.0 hsdR 3.1.21.3 V Type I restriction enzyme R protein N terminus (HSDR_N)
HMECEDPK_00730 1.6e-21 MA20_36090 S Protein of unknown function (DUF2974)
HMECEDPK_00731 7.2e-23 MA20_36090 S Protein of unknown function (DUF2974)
HMECEDPK_00732 2.3e-113 1.14.14.5 C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HMECEDPK_00733 2.1e-27 P Hemerythrin HHE cation binding domain protein
HMECEDPK_00734 2.8e-155 XK27_00880 3.5.1.28 M Glycosyl hydrolase, family 25
HMECEDPK_00735 1e-81 ybaK S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HMECEDPK_00736 6.6e-116 pgm6 5.4.2.11, 5.4.2.12 G phosphoglycerate mutase
HMECEDPK_00737 7.5e-174 S hydrolase
HMECEDPK_00738 7.6e-16
HMECEDPK_00739 1e-163 M LysM domain
HMECEDPK_00740 9.9e-288 lysS 6.1.1.6 J Belongs to the class-II aminoacyl-tRNA synthetase family
HMECEDPK_00741 0.0 L helicase
HMECEDPK_00742 1.2e-67 nudG 3.6.1.55, 3.6.1.65 L Belongs to the Nudix hydrolase family
HMECEDPK_00743 9.6e-12
HMECEDPK_00744 5.1e-235 mntH P H( )-stimulated, divalent metal cation uptake system
HMECEDPK_00745 1.1e-33 XK27_12190 S protein conserved in bacteria
HMECEDPK_00747 8.4e-88 bioY S biotin synthase
HMECEDPK_00748 8.1e-46 S CHY zinc finger
HMECEDPK_00749 3.4e-252 yegQ O Peptidase U32
HMECEDPK_00750 2e-177 yegQ O Peptidase U32
HMECEDPK_00752 2.1e-68 ytxH S General stress protein
HMECEDPK_00754 4e-147 lgt 2.1.1.199 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HMECEDPK_00755 1e-170 hprK F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HMECEDPK_00756 9.9e-42 pspC KT PspC domain
HMECEDPK_00757 0.0 yhgF K Transcriptional accessory protein
HMECEDPK_00759 2.1e-155 XK27_03015 S permease
HMECEDPK_00760 2.7e-146 ycgQ S TIGR03943 family
HMECEDPK_00761 2.6e-194 S CRISPR-associated protein Csn2 subfamily St
HMECEDPK_00762 3.1e-53 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HMECEDPK_00763 4.2e-172 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HMECEDPK_00764 0.0 cas9 L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
HMECEDPK_00765 3.1e-195 cas9 L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
HMECEDPK_00766 1.1e-94
HMECEDPK_00767 5.7e-34 estA E GDSL-like Lipase/Acylhydrolase
HMECEDPK_00768 7.8e-50 dam 2.1.1.72 L D12 class N6 adenine-specific DNA methyltransferase
HMECEDPK_00769 1e-31 K Cro/C1-type HTH DNA-binding domain
HMECEDPK_00770 4.7e-106
HMECEDPK_00771 1.3e-254 rumA 2.1.1.190 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HMECEDPK_00772 4.5e-97 mip S hydroperoxide reductase activity
HMECEDPK_00773 2.4e-203 I acyl-CoA dehydrogenase
HMECEDPK_00774 2.2e-149 ydiA P C4-dicarboxylate transporter malic acid transport protein
HMECEDPK_00775 2.6e-253 msrR K Transcriptional regulator
HMECEDPK_00776 2.3e-153 pheA 4.2.1.51 E Prephenate dehydratase
HMECEDPK_00777 1.7e-87 aroK 1.1.1.25, 2.7.1.71, 4.2.1.10, 4.2.3.4 F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HMECEDPK_00778 7.5e-236 aroA 1.3.1.12, 1.3.1.43, 2.5.1.19 E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
HMECEDPK_00779 3e-173 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
HMECEDPK_00780 3.2e-53 yheA S Belongs to the UPF0342 family
HMECEDPK_00781 2.2e-207 tyrA 1.3.1.12, 1.3.1.43 E prephenate dehydrogenase
HMECEDPK_00782 4.5e-219 aroC 4.2.3.5 E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HMECEDPK_00783 3.5e-202 aroB 2.7.1.71, 4.2.3.4 E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HMECEDPK_00784 1.7e-162 aroE 1.1.1.25 E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HMECEDPK_00785 8.6e-122 aroD 1.1.1.25, 4.2.1.10 E Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
HMECEDPK_00786 2e-219 ywbD 2.1.1.191 J Methyltransferase
HMECEDPK_00787 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
HMECEDPK_00788 2e-25 WQ51_00785
HMECEDPK_00789 9.6e-247 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
HMECEDPK_00790 1e-78 yueI S Protein of unknown function (DUF1694)
HMECEDPK_00791 1.3e-207 glxK 2.7.1.165 G Belongs to the glycerate kinase type-1 family
HMECEDPK_00792 6.6e-101 yyaQ V Protein conserved in bacteria
HMECEDPK_00793 2.8e-28 yyaQ S YjbR
HMECEDPK_00794 4.4e-183 ccpA K Catabolite control protein A
HMECEDPK_00795 4.2e-211 pepQ 3.4.13.9 E Belongs to the peptidase M24B family
HMECEDPK_00796 1.7e-63 yugI 5.3.1.9 J RNA binding protein, contains ribosomal protein S1 domain
HMECEDPK_00797 9.6e-277 ppiB 5.2.1.8 G PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HMECEDPK_00798 1.1e-80 smpB O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
HMECEDPK_00799 0.0 rnr J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
HMECEDPK_00800 2e-33 secG U Preprotein translocase subunit SecG
HMECEDPK_00801 9.5e-74 mdtG EGP Major facilitator Superfamily
HMECEDPK_00802 6e-133 mdtG EGP Major facilitator Superfamily
HMECEDPK_00803 1.1e-104 coaE 2.7.1.24, 3.2.2.23, 4.2.99.18 GH23 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HMECEDPK_00804 1.2e-154 fpg 3.2.2.23, 4.2.99.18 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
HMECEDPK_00805 1.3e-165 era M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HMECEDPK_00806 1.7e-64 dgkA 2.7.1.107, 2.7.1.66 M Diacylglycerol kinase
HMECEDPK_00807 1.1e-86 ybeY 2.6.99.2, 3.5.4.5 S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HMECEDPK_00808 6.8e-53 licT K transcriptional antiterminator
HMECEDPK_00809 9.2e-43 licT K transcriptional antiterminator
HMECEDPK_00811 2.2e-105 recR L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HMECEDPK_00812 0.0 pbp2b 3.4.16.4 M penicillin-binding protein
HMECEDPK_00813 7.8e-149 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HMECEDPK_00814 3.9e-156 folD 1.5.1.5, 3.5.4.9 F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HMECEDPK_00815 7.5e-23 I Alpha/beta hydrolase family
HMECEDPK_00816 1.5e-35 yugF I carboxylic ester hydrolase activity
HMECEDPK_00817 2.2e-45 K sequence-specific DNA binding
HMECEDPK_00818 2.4e-104 1.1.1.133, 5.1.3.13 M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
HMECEDPK_00819 1.5e-07
HMECEDPK_00820 0.0 feoB P transporter of a GTP-driven Fe(2 ) uptake system
HMECEDPK_00821 3.1e-78 feoA P FeoA domain protein
HMECEDPK_00822 2.2e-131 glnQ 3.6.3.21 E abc transporter atp-binding protein
HMECEDPK_00823 7.5e-118 WQ51_01820 P Binding-protein-dependent transport system inner membrane component
HMECEDPK_00824 1.3e-34 ykuJ S protein conserved in bacteria
HMECEDPK_00825 2.6e-180 argF 2.1.3.3 E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HMECEDPK_00826 0.0 clpE O Belongs to the ClpA ClpB family
HMECEDPK_00827 6.7e-86 mutT 3.5.4.33, 3.6.1.13, 3.6.1.55 L Belongs to the Nudix hydrolase family
HMECEDPK_00828 3.7e-48 XK27_09445 S Domain of unknown function (DUF1827)
HMECEDPK_00829 9.7e-66 S oxidoreductase
HMECEDPK_00830 9.3e-59 S oxidoreductase
HMECEDPK_00831 1.3e-232 murN 2.3.2.10, 2.3.2.16 V FemAB family
HMECEDPK_00832 6.1e-70 M Pfam SNARE associated Golgi protein
HMECEDPK_00833 2.6e-101 S Domain of Unknown Function with PDB structure (DUF3862)
HMECEDPK_00836 8.4e-205 rpsA 1.17.7.4 J ribosomal protein S1
HMECEDPK_00839 4.8e-16 S Protein of unknown function (DUF2969)
HMECEDPK_00840 2.4e-200 ilvE 2.6.1.42 E Aminotransferase
HMECEDPK_00841 0.0 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HMECEDPK_00842 0.0 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HMECEDPK_00843 7.1e-102 plsY 2.3.1.15, 3.5.1.104 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
HMECEDPK_00844 4.9e-15 L Helix-hairpin-helix DNA-binding motif class 1
HMECEDPK_00845 1.4e-29 S Domain of unknown function (DUF1912)
HMECEDPK_00846 1.2e-177 mmuM 1.5.1.20, 2.1.1.10 H Homocysteine
HMECEDPK_00847 4.1e-248 mmuP E amino acid
HMECEDPK_00848 4.3e-109 engB D Necessary for normal cell division and for the maintenance of normal septation
HMECEDPK_00849 2e-225 clpX O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HMECEDPK_00850 9.7e-22
HMECEDPK_00851 3.4e-91 folA 1.5.1.3, 1.5.1.47, 2.1.1.45, 3.5.4.12 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HMECEDPK_00852 2.2e-167 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HMECEDPK_00853 1.7e-218 mvaS 2.3.3.10 I synthase
HMECEDPK_00854 2.7e-233 mvaA 1.1.1.34, 1.1.1.88, 2.3.1.9 C Belongs to the HMG-CoA reductase family
HMECEDPK_00855 1.1e-116 yqfA K protein, Hemolysin III
HMECEDPK_00856 1.2e-22 S Protein of unknown function (DUF3114)
HMECEDPK_00857 9.8e-163 S Protein of unknown function (DUF3114)
HMECEDPK_00858 9.9e-169 S hydrolases or acyltransferases (alpha beta hydrolase superfamily)
HMECEDPK_00859 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HMECEDPK_00860 4.9e-21 XK27_13030
HMECEDPK_00861 1.8e-248 mgs 2.4.1.337 GT4 M Glycosyltransferase, group 1 family protein
HMECEDPK_00862 1.4e-192 dgs 2.4.1.208 GT4 M Glycosyltransferase, group 1 family protein
HMECEDPK_00863 4.8e-07 U protein secretion
HMECEDPK_00864 2.7e-50 U protein secretion
HMECEDPK_00865 3.5e-07 U protein secretion
HMECEDPK_00867 5.9e-118 mtnN 3.2.2.9 E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HMECEDPK_00868 2.5e-21
HMECEDPK_00869 8.5e-96 nudF 3.6.1.13 L AdP-ribose pyrophosphatase
HMECEDPK_00870 5.1e-254 glmU 2.3.1.157, 2.7.7.23 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HMECEDPK_00871 8.9e-192 fni 1.1.1.88, 5.3.3.2 C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
HMECEDPK_00872 4.6e-180 mvaK2 2.7.1.36, 2.7.1.43, 2.7.4.2 I GHMP kinases N terminal domain
HMECEDPK_00873 6e-174 mvaD 4.1.1.33 I diphosphomevalonate decarboxylase
HMECEDPK_00874 2.5e-142 mvk 1.1.1.88, 2.3.3.10, 2.7.1.36 I mevalonate kinase
HMECEDPK_00875 1.4e-104 GBS0088 J protein conserved in bacteria
HMECEDPK_00876 8e-249 merA 1.16.1.1 C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HMECEDPK_00877 2.2e-46 ald 1.4.1.1 C Belongs to the AlaDH PNT family
HMECEDPK_00878 3.4e-17 ald 1.4.1.1 E alanine dehydrogenase activity
HMECEDPK_00879 8e-221 hipO 3.5.1.47 E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
HMECEDPK_00880 7.4e-132 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
HMECEDPK_00881 5.6e-113 S VIT family
HMECEDPK_00882 1.5e-143 deoD_1 2.4.2.3 F Phosphorylase superfamily
HMECEDPK_00883 4.3e-22
HMECEDPK_00884 1e-195 yceA S Belongs to the UPF0176 family
HMECEDPK_00885 5.4e-122 sagI S ABC-2 type transporter
HMECEDPK_00886 4.8e-168 V ABC transporter
HMECEDPK_00887 1.1e-217 2.7.7.73, 2.7.7.80 H Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
HMECEDPK_00888 2.1e-131 rr02 KT response regulator
HMECEDPK_00889 1.3e-214 2.7.13.3 T signal transduction protein with a C-terminal ATPase domain
HMECEDPK_00890 3.4e-121 nagB 3.1.1.31, 3.5.99.6 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
HMECEDPK_00891 4.6e-199 queA 2.4.99.17 J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HMECEDPK_00892 0.0 lmrA V abc transporter atp-binding protein
HMECEDPK_00893 0.0 mdlB V abc transporter atp-binding protein
HMECEDPK_00895 0.0 M the current gene model (or a revised gene model) may contain a
HMECEDPK_00896 1.9e-49 M YSIRK type signal peptide
HMECEDPK_00897 3e-92 S MucBP domain
HMECEDPK_00898 0.0 3.6.3.8 P cation transport ATPase
HMECEDPK_00899 0.0 pabB 2.6.1.85, 4.1.3.27, 4.1.3.38 EH component I
HMECEDPK_00901 0.0 metE 2.1.1.14 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HMECEDPK_00902 7.3e-166 metF 1.5.1.20 E reductase
HMECEDPK_00903 0.0 pgm 5.4.2.2, 5.4.2.8 G Phosphoglucomutase
HMECEDPK_00904 1.7e-94 panT S ECF transporter, substrate-specific component
HMECEDPK_00905 4.8e-94 coaBC 4.1.1.36, 6.3.2.5 H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HMECEDPK_00906 1.2e-120 coaB 4.1.1.36, 6.3.2.5 H Phosphopantothenate-cysteine ligase
HMECEDPK_00907 0.0 fhs 6.3.4.3 F Belongs to the formate--tetrahydrofolate ligase family
HMECEDPK_00908 6.4e-66 T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HMECEDPK_00909 2.8e-40 T PhoQ Sensor
HMECEDPK_00910 2.2e-43 T PhoQ Sensor
HMECEDPK_00911 3.6e-88 T PhoQ Sensor
HMECEDPK_00912 1.3e-54 bta 1.8.1.8 CO cell redox homeostasis
HMECEDPK_00913 3.1e-10 L thioesterase
HMECEDPK_00914 7.8e-143 S Macro domain protein
HMECEDPK_00915 4.8e-51 trxA O Belongs to the thioredoxin family
HMECEDPK_00916 6.1e-73 yccU S CoA-binding protein
HMECEDPK_00917 4.1e-144 tatD L Hydrolase, tatd
HMECEDPK_00918 3.2e-98 rnmV 3.1.26.8 J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HMECEDPK_00919 8.9e-156 ksgA 2.1.1.182 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
HMECEDPK_00921 7.6e-163 rsgA 3.1.3.100 G One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
HMECEDPK_00922 3e-119 rpe 5.1.3.1 G Belongs to the ribulose-phosphate 3-epimerase family
HMECEDPK_00923 3.1e-118 thiN 2.7.6.2 H thiamine pyrophosphokinase
HMECEDPK_00924 6.9e-173 rmuC S RmuC domain protein
HMECEDPK_00925 3.6e-179 cbf S 3'-5' exoribonuclease yhaM
HMECEDPK_00926 1.1e-142 purR 2.4.2.7 F operon repressor
HMECEDPK_00927 2.3e-69 rpsL J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HMECEDPK_00928 6.7e-81 rpsG J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
HMECEDPK_00929 0.0 fusA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HMECEDPK_00930 1.4e-189 gap 1.2.1.12 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
HMECEDPK_00931 1.2e-165 L integrase core domain
HMECEDPK_00932 5.6e-121 L Helix-turn-helix domain
HMECEDPK_00933 0.0 prtS 3.4.21.96 O Belongs to the peptidase S8 family
HMECEDPK_00934 3.1e-268 clcA P Chloride transporter, ClC family
HMECEDPK_00935 8.9e-206 potD P spermidine putrescine ABC transporter
HMECEDPK_00936 1.7e-28 potC P Binding-protein-dependent transport system inner membrane component
HMECEDPK_00938 1.5e-95 cysE 2.3.1.30 E Bacterial transferase hexapeptide (six repeats)
HMECEDPK_00939 9.1e-220 metC 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
HMECEDPK_00940 2.3e-170 mccA 2.5.1.134, 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
HMECEDPK_00941 9e-164 fba 4.1.2.13, 4.1.2.29 G aldolase
HMECEDPK_00943 8.8e-110 6.3.2.2 H ergothioneine biosynthetic process
HMECEDPK_00944 1.5e-65 6.3.2.2 H gamma-glutamylcysteine synthetase
HMECEDPK_00945 2.2e-12 6.3.2.2 H gamma-glutamylcysteine synthetase
HMECEDPK_00946 1.3e-117 devA 3.6.3.25 V abc transporter atp-binding protein
HMECEDPK_00947 2.8e-164 hrtB V MacB-like periplasmic core domain
HMECEDPK_00950 0.0 copB 3.6.3.4 P P-type ATPase
HMECEDPK_00951 5e-84 L Transposase
HMECEDPK_00952 1.7e-226 tgt 2.4.2.29 F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
HMECEDPK_00954 1.2e-165 L integrase core domain
HMECEDPK_00955 6.7e-122 L Helix-turn-helix domain
HMECEDPK_00956 8.6e-265 gapN 1.2.1.9 C Belongs to the aldehyde dehydrogenase family
HMECEDPK_00957 2.1e-28 6.3.2.2, 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
HMECEDPK_00958 2.1e-178 yfmL 3.6.4.13 L DEAD DEAH box helicase
HMECEDPK_00959 2.1e-114 udk 2.7.1.48 F Cytidine monophosphokinase
HMECEDPK_00960 0.0 uup S abc transporter atp-binding protein
HMECEDPK_00962 1.4e-130 pip 1.11.1.10 S Alpha beta hydrolase
HMECEDPK_00963 0.0 mprF 2.3.2.3 J Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HMECEDPK_00964 8.7e-150 cobQ S glutamine amidotransferase
HMECEDPK_00965 1.8e-253 murD 3.4.21.10, 6.3.2.13, 6.3.2.9 M Mur ligase, middle domain protein
HMECEDPK_00966 5.6e-124 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HMECEDPK_00967 6e-169 ybbR S Protein conserved in bacteria
HMECEDPK_00968 1.5e-250 glmM 5.4.2.10 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HMECEDPK_00969 1.7e-70 gtrA S GtrA-like protein
HMECEDPK_00970 2.7e-123 trmK 2.1.1.217 S SAM-dependent methyltransferase
HMECEDPK_00971 9.6e-149 yqfO 3.5.4.16 S Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HMECEDPK_00972 6.3e-101 zupT P Mediates zinc uptake. May also transport other divalent cations
HMECEDPK_00973 1.1e-206 yurR 1.4.5.1 E oxidoreductase
HMECEDPK_00974 4.1e-161 rfbA 2.7.7.24 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HMECEDPK_00975 8.3e-113 rmlC 1.1.1.133, 5.1.3.13 M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
HMECEDPK_00976 1.9e-205 rfbB 4.2.1.46 M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
HMECEDPK_00979 4.1e-217 hemN H Involved in the biosynthesis of porphyrin-containing compound
HMECEDPK_00980 1.5e-143 fat 3.1.2.21 I Acyl-ACP thioesterase
HMECEDPK_00981 5.9e-143 nagD 2.7.1.25, 3.1.3.41 G Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
HMECEDPK_00982 1.1e-121 ylfI S tigr01906
HMECEDPK_00983 2e-140 hisK 3.1.3.15 E Histidinol phosphatase and related hydrolases of the PHP family
HMECEDPK_00984 2.3e-09 XK27_08080 3.1.1.53 G Exopolysaccharide biosynthesis protein
HMECEDPK_00985 5.6e-92 XK27_08080 3.1.1.53 G Exopolysaccharide biosynthesis protein
HMECEDPK_00986 1.3e-22 XK27_08085
HMECEDPK_00987 5.2e-36 L transposase activity
HMECEDPK_00988 8.2e-22 L Transposase
HMECEDPK_00989 1.6e-55 L transposition
HMECEDPK_00990 6.6e-31 L Integrase core domain protein
HMECEDPK_00992 4.1e-195 hisC 2.6.1.9 E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HMECEDPK_00993 5.7e-183 hisZ 2.4.2.17, 6.1.1.21 E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HMECEDPK_00994 1.4e-116 hisG 2.4.2.17 E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
HMECEDPK_00995 1.2e-228 hisD 1.1.1.23, 1.1.1.308 E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HMECEDPK_00996 2.2e-105 hisB 1.1.1.23, 2.6.1.9, 3.1.3.15, 4.2.1.19 E imidazoleglycerol-phosphate dehydratase
HMECEDPK_00997 6.3e-108 hisH E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HMECEDPK_00998 1.9e-127 hisA 5.3.1.16 E 1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HMECEDPK_00999 5.8e-135 hisF 3.5.4.19, 3.6.1.31 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
HMECEDPK_01000 5.5e-61 hisI 3.5.4.19, 3.5.4.25, 3.6.1.31, 5.3.1.16 E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HMECEDPK_01001 1.8e-50 hisE 3.5.4.19, 3.6.1.31, 5.3.1.16 E Phosphoribosyl-ATP
HMECEDPK_01002 5.6e-240 rodA D Belongs to the SEDS family
HMECEDPK_01003 1.4e-223 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HMECEDPK_01004 4.2e-118 galT 2.7.7.12 G UDPglucose--hexose-1-phosphate uridylyltransferase
HMECEDPK_01005 9.2e-175 rnz 3.1.26.11 S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
HMECEDPK_01006 6.7e-139 XK27_05435 1.1.1.100 S Belongs to the short-chain dehydrogenases reductases (SDR) family
HMECEDPK_01007 0.0 recJ L Single-strand DNA-specific exonuclease, C terminal domain
HMECEDPK_01008 2e-94 apt 2.4.2.22, 2.4.2.7 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HMECEDPK_01009 9.3e-183 metA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HMECEDPK_01010 2.9e-125 dnaD
HMECEDPK_01011 3.4e-120 nth 4.2.99.18 L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HMECEDPK_01014 1.2e-247 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HMECEDPK_01015 3.5e-29 xseB 3.1.11.6 L exodeoxyribonuclease VII activity
HMECEDPK_01016 3e-159 ispA 2.5.1.1, 2.5.1.10, 2.5.1.29, 2.5.1.90 H Belongs to the FPP GGPP synthase family
HMECEDPK_01017 4.3e-158 rrmJ 2.1.1.226, 2.1.1.227 J Ribosomal RNA large subunit methyltransferase J
HMECEDPK_01018 1.8e-72 argR K Regulates arginine biosynthesis genes
HMECEDPK_01019 5.8e-305 recN L May be involved in recombinational repair of damaged DNA
HMECEDPK_01020 1e-148 DegV S DegV family
HMECEDPK_01021 6e-144 ypmR E lipolytic protein G-D-S-L family
HMECEDPK_01022 2.1e-84 ypmS S Protein conserved in bacteria
HMECEDPK_01023 2.8e-39 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
HMECEDPK_01025 2.5e-180 pyrD 1.3.1.14, 1.3.98.1 F Catalyzes the conversion of dihydroorotate to orotate
HMECEDPK_01026 4.6e-131 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HMECEDPK_01027 5.9e-291 leuA 2.3.3.13 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HMECEDPK_01028 6.6e-190 leuB 1.1.1.85 CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
HMECEDPK_01029 3.3e-43 ysdA L Membrane
HMECEDPK_01030 6.8e-275 leuC 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HMECEDPK_01031 1.2e-111 leuD 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HMECEDPK_01032 4.1e-152 sua5 2.7.7.87 J Belongs to the SUA5 family
HMECEDPK_01033 0.0 dnaE 2.7.7.7 L DNA polymerase
HMECEDPK_01034 1.2e-188 pfkA 2.7.1.11 F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
HMECEDPK_01035 3.9e-276 pyk 2.7.1.40, 2.7.7.4 G Belongs to the pyruvate kinase family
HMECEDPK_01038 7e-27 Q the current gene model (or a revised gene model) may contain a frame shift
HMECEDPK_01039 1.1e-43 Q the current gene model (or a revised gene model) may contain a frame shift
HMECEDPK_01041 1.6e-16 S Domain of unknown function (DUF4649)
HMECEDPK_01042 3.3e-178 XK27_08835 S ABC transporter substrate binding protein
HMECEDPK_01043 4e-148 XK27_08840 S Belongs to the binding-protein-dependent transport system permease family
HMECEDPK_01044 1.2e-135 XK27_08845 S abc transporter atp-binding protein
HMECEDPK_01045 7.8e-310 rnjB S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HMECEDPK_01046 3.5e-151 estA CE1 S Putative esterase
HMECEDPK_01047 4.7e-126 XK27_08875 O Zinc-dependent metalloprotease
HMECEDPK_01048 3.3e-14 XK27_08880
HMECEDPK_01049 2.3e-75 fld C Flavodoxin
HMECEDPK_01050 3.7e-282 clcA P Chloride transporter, ClC family
HMECEDPK_01051 8.7e-41 pheA 1.3.1.12, 2.3.1.79, 4.2.1.51, 5.4.99.5 E Chorismate mutase
HMECEDPK_01052 3.2e-220 XK27_05110 P chloride
HMECEDPK_01053 8.5e-57 rplS J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
HMECEDPK_01056 2.7e-19 WQ51_02665 S Protein of unknown function (DUF3042)
HMECEDPK_01057 1.3e-165 miaA 2.5.1.75 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HMECEDPK_01058 6.1e-88 ytsP 1.8.4.14 T GAF domain-containing protein
HMECEDPK_01059 4.1e-295 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HMECEDPK_01060 1.2e-174 birA 6.3.4.15 HK Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
HMECEDPK_01061 2.1e-203 metK 2.5.1.6 H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HMECEDPK_01062 3.5e-26 G Domain of unknown function (DUF4832)
HMECEDPK_01063 1.9e-194 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
HMECEDPK_01065 9.4e-231 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HMECEDPK_01066 1.2e-25 epuA S DNA-directed RNA polymerase subunit beta
HMECEDPK_01067 3.5e-123 endA F DNA RNA non-specific endonuclease
HMECEDPK_01068 2.5e-110 tcyB_2 P ABC transporter (permease)
HMECEDPK_01069 8e-115 gltJ P ABC transporter (Permease
HMECEDPK_01070 9.2e-150 peb1A ET ABC-type amino acid transport signal transduction systems, periplasmic component domain
HMECEDPK_01071 3.3e-138 glnQ 3.6.3.21 E abc transporter atp-binding protein
HMECEDPK_01072 9.9e-129 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HMECEDPK_01073 1.4e-245 vicK 2.7.13.3 T Histidine kinase
HMECEDPK_01074 1e-153 vicX 3.1.26.11 S Metal-dependent hydrolases of the beta-lactamase superfamily I
HMECEDPK_01075 9e-231 murM 2.3.2.10, 2.3.2.16 V protein involved in methicillin resistance
HMECEDPK_01076 9.2e-147 yidA S hydrolases of the HAD superfamily
HMECEDPK_01077 6.3e-51 XK27_00115 2.3.1.128 K acetyltransferase
HMECEDPK_01078 2.6e-67 ywiB S Domain of unknown function (DUF1934)
HMECEDPK_01079 0.0 pacL 3.6.3.8 P cation transport ATPase
HMECEDPK_01080 1.5e-135 nfrA 1.5.1.38, 1.5.1.39 C nitroreductase
HMECEDPK_01081 1.3e-181 yjjH S Calcineurin-like phosphoesterase
HMECEDPK_01082 1.2e-202 queG 1.17.99.6 C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HMECEDPK_01083 1.6e-182 prfB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HMECEDPK_01084 2.5e-124 ftsE D cell division ATP-binding protein FtsE
HMECEDPK_01085 3.6e-163 ftsX D Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation
HMECEDPK_01086 4.6e-93 mutX 3.6.1.55 F NTP pyrophosphohydrolases including oxidative damage repair enzymes
HMECEDPK_01087 6.2e-176 yubA S permease
HMECEDPK_01088 2.4e-223 G COG0457 FOG TPR repeat
HMECEDPK_01089 1.8e-96 lepB 3.4.21.89 U Belongs to the peptidase S26 family
HMECEDPK_01090 1.1e-228 pepT 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
HMECEDPK_01091 2.9e-90 ebsA S Family of unknown function (DUF5322)
HMECEDPK_01092 2.8e-18 M LysM domain
HMECEDPK_01093 2.5e-121 cmk 1.17.7.4, 2.5.1.19, 2.7.1.26, 2.7.4.25, 2.7.7.2, 6.3.2.1 F Belongs to the cytidylate kinase family. Type 1 subfamily
HMECEDPK_01094 3.5e-86 infC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HMECEDPK_01095 2.1e-28 rpmI J Belongs to the bacterial ribosomal protein bL35 family
HMECEDPK_01096 1.5e-56 rplT J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HMECEDPK_01097 2e-85 XK27_03610 K Gnat family
HMECEDPK_01098 6.4e-27 dmpI 5.3.2.6 G Belongs to the 4-oxalocrotonate tautomerase family
HMECEDPK_01099 9e-275 pepV 3.5.1.18 E Dipeptidase
HMECEDPK_01100 1e-110 ung2 3.2.2.27 L Uracil-DNA glycosylase
HMECEDPK_01101 6.1e-22 V Glucan-binding protein C
HMECEDPK_01103 1.7e-122 rpiA 2.7.1.12, 2.7.1.15, 5.3.1.6 G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HMECEDPK_01104 9.3e-236 deoB 5.4.2.7 G Phosphotransfer between the C1 and C5 carbon atoms of pentose
HMECEDPK_01105 4e-150 punA 2.4.2.1 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HMECEDPK_01106 3.7e-67 yfeJ 6.3.5.2 F glutamine amidotransferase
HMECEDPK_01107 7e-38 yfeJ 6.3.5.2 F glutamine amidotransferase
HMECEDPK_01108 5.8e-129 deoD 2.4.2.1, 2.4.2.28 F purine nucleoside phosphorylase
HMECEDPK_01109 1.5e-251 cps4A K Cell envelope-like function transcriptional attenuator common domain protein
HMECEDPK_01110 1.1e-135 cpsB 3.1.3.48 GM Capsular polysaccharide biosynthesis protein
HMECEDPK_01111 4.7e-107 cps4C M biosynthesis protein
HMECEDPK_01112 1.1e-117 cpsD D COG0489 ATPases involved in chromosome partitioning
HMECEDPK_01113 2.7e-255 cpsE M Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
HMECEDPK_01114 4.5e-219 rgpAc GT4 M group 1 family protein
HMECEDPK_01115 1.1e-209 wcoF M Glycosyltransferase, group 1 family protein
HMECEDPK_01116 8.5e-87 Z012_10770 M Domain of unknown function (DUF1919)
HMECEDPK_01117 1.1e-149 M Glycosyltransferase, group 2 family protein
HMECEDPK_01118 7.8e-60 sacB GT2,GT4 M Stealth protein CR2, conserved region 2
HMECEDPK_01119 2.9e-80 sacB GT2,GT4 M transferase activity, transferring glycosyl groups
HMECEDPK_01120 1.7e-36 S Psort location CytoplasmicMembrane, score 9.99
HMECEDPK_01121 1.2e-141 cps1B GT2,GT4 M Glycosyl transferases group 1
HMECEDPK_01122 7.3e-248 cps1C S Polysaccharide biosynthesis protein
HMECEDPK_01123 2.7e-160 rfbA 2.7.7.24 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HMECEDPK_01124 5.6e-20 rmlC 1.1.1.133, 5.1.3.13 M dTDP-4-dehydrorhamnose 3,5-epimerase
HMECEDPK_01125 1.6e-249 L Transposase
HMECEDPK_01126 1.6e-18 L Integrase core domain
HMECEDPK_01127 1.5e-42 L Transposase
HMECEDPK_01128 3.9e-52 rplL J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
HMECEDPK_01129 1.6e-77 rplJ J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HMECEDPK_01130 1.2e-26 ytrF V efflux transmembrane transporter activity
HMECEDPK_01131 3.1e-31 V efflux transmembrane transporter activity
HMECEDPK_01132 3.6e-35 V efflux transmembrane transporter activity
HMECEDPK_01133 4.4e-30 acrA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HMECEDPK_01134 6.4e-134 2.1.1.223 S Putative SAM-dependent methyltransferase
HMECEDPK_01135 0.0 carB 6.3.5.5 F carbamoyl-phosphate synthetase ammonia chain
HMECEDPK_01136 1.1e-211 carA 6.3.5.5 F carbamoyl-phosphate synthetase glutamine chain
HMECEDPK_01137 1e-173 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
HMECEDPK_01138 4.9e-227 pyrP F uracil Permease
HMECEDPK_01139 4e-87 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HMECEDPK_01140 5e-162 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
HMECEDPK_01141 8.8e-78 lspA 3.4.23.36 MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HMECEDPK_01142 1.8e-167 fhuR K transcriptional regulator (lysR family)
HMECEDPK_01147 1.6e-140 ppiA 5.2.1.8 O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HMECEDPK_01148 3.3e-77 2.7.1.199, 2.7.1.211 G PTS glucose transporter subunit IIA
HMECEDPK_01149 4.2e-119 pts33BCA G pts system
HMECEDPK_01150 1.4e-47 pts33BCA G pts system
HMECEDPK_01151 1.5e-25 2.7.1.208, 2.7.1.211 G protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMECEDPK_01152 1.1e-09 uvrX 2.7.7.7 L ImpB mucB samB family
HMECEDPK_01153 1.8e-254 cycA E permease
HMECEDPK_01154 4.5e-39 ynzC S UPF0291 protein
HMECEDPK_01155 0.0 glyS 6.1.1.14 J Glycyl-tRNA synthetase beta subunit
HMECEDPK_01156 4.8e-176 glyQ 6.1.1.14 J glycyl-tRNA synthetase alpha subunit
HMECEDPK_01157 6.1e-63 S membrane
HMECEDPK_01158 1.5e-59
HMECEDPK_01159 7.5e-26
HMECEDPK_01160 1.8e-53
HMECEDPK_01161 3.6e-221 nagA 3.5.1.25 G Belongs to the metallo-dependent hydrolases superfamily. NagA family
HMECEDPK_01162 2.1e-68 nptA P sodium-dependent phosphate transmembrane transporter activity
HMECEDPK_01163 5.8e-149 XK27_04800 S Sucrose-6F-phosphate phosphohydrolase
HMECEDPK_01164 4.9e-106 mur1 NU mannosyl-glycoprotein
HMECEDPK_01165 1.1e-53 glnB K Belongs to the P(II) protein family
HMECEDPK_01166 5.2e-226 amt P Ammonium Transporter
HMECEDPK_01167 2.7e-160 rsmI 2.1.1.198 H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HMECEDPK_01168 9.5e-55 yabA L Involved in initiation control of chromosome replication
HMECEDPK_01169 1.2e-135 yaaT S stage 0 sporulation protein
HMECEDPK_01170 6.4e-162 holB 2.7.7.7 L dna polymerase iii
HMECEDPK_01171 1.1e-110 tmk 2.7.4.9 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HMECEDPK_01172 1.4e-136 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
HMECEDPK_01173 9.5e-225 tuf J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HMECEDPK_01174 2.8e-230 ftsW D Belongs to the SEDS family
HMECEDPK_01175 2e-66 atpC C Produces ATP from ADP in the presence of a proton gradient across the membrane
HMECEDPK_01176 2.7e-263 atpD 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HMECEDPK_01177 2.5e-158 atpG C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HMECEDPK_01178 3.8e-279 atpA 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HMECEDPK_01179 9.3e-87 atpH C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HMECEDPK_01180 3.3e-78 atpF C ATP synthase F(0) sector subunit b
HMECEDPK_01181 4.3e-124 atpB C it plays a direct role in the translocation of protons across the membrane
HMECEDPK_01182 3.2e-16 atpE C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HMECEDPK_01183 0.0 valS 6.1.1.9 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
HMECEDPK_01184 1.9e-46 2.3.1.128, 5.2.1.8 J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HMECEDPK_01185 4.1e-112 S COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HMECEDPK_01186 8.9e-14 coiA 3.6.4.12 S Competence protein
HMECEDPK_01187 2.2e-15 T peptidase
HMECEDPK_01188 5.5e-153 rarD S Transporter
HMECEDPK_01189 1.1e-153 thrB 2.7.1.39 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
HMECEDPK_01190 1.8e-237 hom 1.1.1.3, 2.7.2.4 E homoserine dehydrogenase
HMECEDPK_01191 3.7e-140 yxkH G deacetylase
HMECEDPK_01192 9e-209 argD 2.6.1.11, 2.6.1.17 E acetylornithine aminotransferase
HMECEDPK_01193 2.1e-129 argB 2.7.2.8 E Belongs to the acetylglutamate kinase family. ArgB subfamily
HMECEDPK_01194 8.6e-210 argJ 2.3.1.1, 2.3.1.35, 2.7.2.8 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HMECEDPK_01195 1.5e-191 argC 1.2.1.38 E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HMECEDPK_01196 5.3e-228 mtnE 2.6.1.83 E mutations do not affect methionine salvage in vivo however
HMECEDPK_01197 4.9e-145 cnhA 3.5.1.3 S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
HMECEDPK_01198 5.6e-119 3.4.17.14, 3.5.1.28 NU amidase activity
HMECEDPK_01199 6.9e-179 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
HMECEDPK_01200 7.9e-24 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
HMECEDPK_01201 0.0 alaS 6.1.1.7 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HMECEDPK_01202 4.6e-168 prsA 3.1.3.16, 5.2.1.8 O peptidyl-prolyl cis-trans isomerase activity
HMECEDPK_01203 5.4e-127 yrrM 2.1.1.104 S O-Methyltransferase
HMECEDPK_01204 0.0 pepF E oligoendopeptidase F
HMECEDPK_01205 1.4e-186 coiA 3.6.4.12 S Competence protein
HMECEDPK_01206 9.2e-164 K transcriptional regulator (lysR family)
HMECEDPK_01207 0.0 metG 6.1.1.10, 6.1.1.20 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HMECEDPK_01211 8e-191 phoH T phosphate starvation-inducible protein PhoH
HMECEDPK_01212 2.3e-61 rlpA M LysM domain protein
HMECEDPK_01213 2.2e-130 usp 3.5.1.104, 3.5.1.28 CBM50 S pathogenesis
HMECEDPK_01214 7.4e-35 yozE S Belongs to the UPF0346 family
HMECEDPK_01215 5.3e-161 cvfB S Protein conserved in bacteria
HMECEDPK_01216 1.3e-91 frr J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
HMECEDPK_01217 4.9e-131 pyrH 2.7.4.22 F Catalyzes the reversible phosphorylation of UMP to UDP
HMECEDPK_01218 3.2e-78 sptS 2.7.13.3 T Histidine kinase
HMECEDPK_01219 5.4e-45 K Acetyltransferase (GNAT) family
HMECEDPK_01220 0.0 lmrA2 V abc transporter atp-binding protein
HMECEDPK_01221 0.0 lmrA1 V abc transporter atp-binding protein
HMECEDPK_01222 1.9e-77 K DNA-binding transcription factor activity
HMECEDPK_01223 1e-69 def_1 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins
HMECEDPK_01224 1.8e-256 gdhA 1.4.1.4 E Belongs to the Glu Leu Phe Val dehydrogenases family
HMECEDPK_01225 3.8e-212 nadD 2.7.1.22, 2.7.7.1, 2.7.7.18, 3.6.1.55 H adenylyltransferase
HMECEDPK_01226 1e-139 3.6.1.13, 3.6.1.55 F AdP-ribose pyrophosphatase
HMECEDPK_01227 3.3e-25 U response to pH
HMECEDPK_01228 0.0 yfmR S abc transporter atp-binding protein
HMECEDPK_01229 9e-223 cca 2.7.7.19, 2.7.7.72 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HMECEDPK_01230 4.3e-138 dapB 1.17.1.8 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
HMECEDPK_01231 2.1e-74 XK27_08360 S EDD domain protein, DegV family
HMECEDPK_01232 6.4e-61 XK27_08360 S EDD domain protein, DegV family
HMECEDPK_01233 2.6e-64 WQ51_03320 S cog cog4835
HMECEDPK_01234 2e-126 ydaF_2 J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HMECEDPK_01235 1.5e-46 rpmA J Belongs to the bacterial ribosomal protein bL27 family
HMECEDPK_01236 4.5e-49 rplU J This protein binds to 23S rRNA in the presence of protein L20
HMECEDPK_01237 6.4e-29 2.3.1.128 K acetyltransferase
HMECEDPK_01238 7.2e-258 gtf2 M A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1
HMECEDPK_01239 3.2e-294 gtf1 2.4.1.52 GT4 M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
HMECEDPK_01240 2.9e-229 thiI 2.8.1.4 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HMECEDPK_01241 6.1e-213 iscS2 2.8.1.7 E Cysteine sulfinate desulfinase cysteine desulfurase and related enzymes
HMECEDPK_01243 2.4e-242 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
HMECEDPK_01244 2.1e-260 gor 1.8.1.7 C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HMECEDPK_01245 1.2e-34 fruA 2.7.1.202 G phosphotransferase system
HMECEDPK_01246 2.7e-126 fruA 2.7.1.202 G phosphotransferase system
HMECEDPK_01247 2.2e-49 fruA 2.7.1.202 GT PTS system, Lactose/Cellobiose specific IIB subunit
HMECEDPK_01248 3.9e-54 fruA 2.7.1.202 GT PTS system, Lactose/Cellobiose specific IIB subunit
HMECEDPK_01249 2.1e-163 pfkB 2.7.1.11, 2.7.1.56 H Belongs to the carbohydrate kinase PfkB family. LacC subfamily
HMECEDPK_01250 5.6e-114 fruR K transcriptional
HMECEDPK_01251 6.8e-84 L Transposase
HMECEDPK_01252 8.1e-203 rny D Endoribonuclease that initiates mRNA decay
HMECEDPK_01253 5.2e-65 tnp L Transposase
HMECEDPK_01254 4.7e-90 luxS 4.4.1.21 H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
HMECEDPK_01255 6.7e-139 accA 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
HMECEDPK_01256 1.6e-160 accD 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HMECEDPK_01257 4.8e-257 accC 6.3.4.14, 6.4.1.2 I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
HMECEDPK_01258 1.5e-71 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
HMECEDPK_01259 7.7e-56 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
HMECEDPK_01260 2.6e-233 fabF 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
HMECEDPK_01261 1.6e-126 IQ reductase
HMECEDPK_01262 8.5e-165 fabD 2.3.1.39 I Malonyl CoA-acyl carrier protein transacylase
HMECEDPK_01263 5.8e-172 fabK 1.3.1.9 S 2-Nitropropane dioxygenase
HMECEDPK_01264 3.3e-30 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
HMECEDPK_01265 2.3e-173 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HMECEDPK_01266 5.8e-71 marR K Transcriptional regulator, MarR family
HMECEDPK_01267 2.4e-139 phaB 5.3.3.14, 5.3.3.18 I Belongs to the enoyl-CoA hydratase isomerase family
HMECEDPK_01268 1.9e-115 S Haloacid dehalogenase-like hydrolase
HMECEDPK_01269 2.4e-256 lysC 2.7.2.4 E Belongs to the aspartokinase family
HMECEDPK_01270 8e-193 asnA 6.3.1.1 E aspartate--ammonia ligase
HMECEDPK_01271 1.4e-259 rumA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HMECEDPK_01272 2.8e-132 recX 2.4.1.337 GT4 S Regulatory protein RecX
HMECEDPK_01273 7.8e-102 ygaC J Belongs to the UPF0374 family
HMECEDPK_01274 6.4e-108 S Domain of unknown function (DUF1803)
HMECEDPK_01275 2.1e-166 ppaC 3.6.1.1 C inorganic pyrophosphatase
HMECEDPK_01283 1.9e-17 L transposase activity
HMECEDPK_01287 1.7e-162 L Transposase
HMECEDPK_01288 0.0 ftsH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HMECEDPK_01289 3.4e-97 hpt 2.4.2.8, 6.3.4.19 F Belongs to the purine pyrimidine phosphoribosyltransferase family
HMECEDPK_01290 7.2e-239 tilS 2.4.2.8, 6.3.4.19 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
HMECEDPK_01291 1.3e-240 XK27_09285 3.5.2.6 V Beta-lactamase enzyme family
HMECEDPK_01293 3.5e-61 divIC D Septum formation initiator
HMECEDPK_01294 1.7e-39 yabO J Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
HMECEDPK_01295 0.0 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HMECEDPK_01296 1.4e-104 pth 3.1.1.29 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
HMECEDPK_01297 1.1e-203 ychF J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
HMECEDPK_01298 1.1e-29 yyzM S Protein conserved in bacteria
HMECEDPK_01299 6.3e-202 dnaN 2.7.7.7 L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
HMECEDPK_01300 1.3e-257 dnaA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HMECEDPK_01301 8.5e-134 parB K Belongs to the ParB family
HMECEDPK_01302 5.3e-194 htrA 3.4.21.107 O Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain'
HMECEDPK_01303 1.1e-86 rlmH 2.1.1.177 J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HMECEDPK_01304 6.2e-120 yoaK S Psort location CytoplasmicMembrane, score
HMECEDPK_01308 0.0 XK27_10405 S Bacterial membrane protein YfhO
HMECEDPK_01309 6.7e-306 ybiT S abc transporter atp-binding protein
HMECEDPK_01310 5.4e-153 yvjA S membrane
HMECEDPK_01311 8.2e-193 trpS 6.1.1.2 J Tryptophanyl-tRNA synthetase
HMECEDPK_01312 1.5e-275 guaB 1.1.1.205 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
HMECEDPK_01313 1.7e-204 recF L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HMECEDPK_01314 2.3e-44 yaaA S S4 domain protein YaaA
HMECEDPK_01315 1.1e-234 ymfF S Peptidase M16
HMECEDPK_01316 3.1e-242 ymfH S Peptidase M16
HMECEDPK_01317 6.3e-138 ymfM S sequence-specific DNA binding
HMECEDPK_01318 3.1e-90 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HMECEDPK_01319 1.5e-152 ecfA1 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HMECEDPK_01320 5.2e-153 ecfA2 3.6.3.55 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HMECEDPK_01321 2e-138 ecfT P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HMECEDPK_01322 5.3e-85 lytE M LysM domain protein
HMECEDPK_01323 1.5e-88 isaA GH23 M Immunodominant staphylococcal antigen A
HMECEDPK_01324 0.0 S Bacterial membrane protein, YfhO
HMECEDPK_01325 8.6e-220 mnmA 2.8.1.13 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
HMECEDPK_01326 1.5e-77 F NUDIX domain
HMECEDPK_01327 0.0 gidA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
HMECEDPK_01328 0.0 yybT T signaling protein consisting of a modified GGDEF domain and a DHH domain
HMECEDPK_01329 3.9e-70 rplI J binds to the 23S rRNA
HMECEDPK_01330 1.5e-245 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
HMECEDPK_01331 8.2e-48 veg S Biofilm formation stimulator VEG
HMECEDPK_01332 9.8e-109 rpsD J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HMECEDPK_01333 2.7e-08
HMECEDPK_01334 4.8e-55 ypaA M Membrane
HMECEDPK_01335 1.6e-94 XK27_06935 K transcriptional regulator
HMECEDPK_01336 3.9e-161 XK27_06930 V domain protein
HMECEDPK_01337 4.8e-106 S Putative adhesin
HMECEDPK_01338 4.3e-61 L COG2801 Transposase and inactivated derivatives
HMECEDPK_01339 1e-45 M Glycosyltransferase family 92
HMECEDPK_01340 8.1e-154 L COG2801 Transposase and inactivated derivatives
HMECEDPK_01341 2.3e-38 L transposase activity
HMECEDPK_01342 9.7e-222 L Transposase
HMECEDPK_01343 8e-49 E IrrE N-terminal-like domain
HMECEDPK_01344 2.3e-55 E IrrE N-terminal-like domain
HMECEDPK_01345 2.1e-08 K Peptidase S24-like protein
HMECEDPK_01346 1.3e-84 K Peptidase S24-like
HMECEDPK_01347 7.6e-22
HMECEDPK_01348 1e-33 L Transposase
HMECEDPK_01349 4.9e-12 K CsbD-like
HMECEDPK_01350 1.2e-71 M Protein conserved in bacteria
HMECEDPK_01351 1.8e-23 S Small integral membrane protein
HMECEDPK_01352 3.1e-101
HMECEDPK_01353 3.7e-27 S Membrane
HMECEDPK_01355 2.7e-95 S Hydrophobic domain protein
HMECEDPK_01356 3.1e-20 yegS 2.7.1.107 I lipid kinase activity
HMECEDPK_01358 6.7e-19 rpmG J Belongs to the bacterial ribosomal protein bL33 family
HMECEDPK_01359 2e-25 rpmF J Belongs to the bacterial ribosomal protein bL32 family
HMECEDPK_01360 9.2e-36 metE 2.1.1.14 E Methionine synthase
HMECEDPK_01361 7.6e-64 metE 2.1.1.14 E Methionine synthase
HMECEDPK_01362 5.7e-52 metE 2.1.1.14 E Methionine synthase
HMECEDPK_01363 1.6e-241 hisS 6.1.1.21 J histidyl-tRNA synthetase
HMECEDPK_01365 0.0 aspS 6.1.1.12 J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
HMECEDPK_01366 9.9e-169 XK27_01785 S cog cog1284
HMECEDPK_01367 7e-147 yaaA S Belongs to the UPF0246 family
HMECEDPK_01368 3.7e-116 nrdG 1.97.1.4 O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HMECEDPK_01369 2.6e-91 XK27_10930 K acetyltransferase
HMECEDPK_01370 7.5e-14
HMECEDPK_01371 0.0 nrdD 1.1.98.6 F Ribonucleoside-triphosphate reductase
HMECEDPK_01372 2.3e-301 ccs S the current gene model (or a revised gene model) may contain a frame shift
HMECEDPK_01373 4.2e-44 yrzB S Belongs to the UPF0473 family
HMECEDPK_01374 1.2e-70 yqgF L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HMECEDPK_01375 2.8e-44 yrzL S Belongs to the UPF0297 family
HMECEDPK_01376 8.4e-27 rpmB J Belongs to the bacterial ribosomal protein bL28 family
HMECEDPK_01377 5.2e-237 rarA L ATPase related to the helicase subunit of the Holliday junction resolvase
HMECEDPK_01379 1.3e-215 int L Belongs to the 'phage' integrase family
HMECEDPK_01380 1.9e-18 S Domain of unknown function (DUF3173)
HMECEDPK_01381 1.6e-106 L Replication initiation factor
HMECEDPK_01382 1e-36 L Replication initiation factor
HMECEDPK_01383 2.5e-89 K sequence-specific DNA binding
HMECEDPK_01384 3.9e-287 V ABC transporter transmembrane region
HMECEDPK_01385 3.4e-191 C Radical SAM
HMECEDPK_01386 6.3e-16 C Radical SAM
HMECEDPK_01388 1.4e-127 Z012_04635 K sequence-specific DNA binding
HMECEDPK_01389 1.5e-89 adk 2.7.4.3 F topology modulation protein
HMECEDPK_01390 1e-248 purA 6.3.4.4 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HMECEDPK_01391 1e-80 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HMECEDPK_01392 1.7e-35 XK27_09805 S MORN repeat protein
HMECEDPK_01393 0.0 XK27_09800 I Acyltransferase
HMECEDPK_01394 7.8e-188 ruvB 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
HMECEDPK_01395 1.3e-48 rpsJ J Involved in the binding of tRNA to the ribosomes
HMECEDPK_01396 1.1e-110 rplC J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HMECEDPK_01397 5.7e-104 rplD J Forms part of the polypeptide exit tunnel
HMECEDPK_01398 2.4e-44 rplW J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
HMECEDPK_01399 8.8e-153 rplB J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HMECEDPK_01400 4.9e-47 rpsS J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HMECEDPK_01401 7.3e-53 rplV J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HMECEDPK_01402 2.1e-117 rpsC J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HMECEDPK_01403 7.2e-71 rplP J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HMECEDPK_01404 2.7e-26 rpmC J Belongs to the universal ribosomal protein uL29 family
HMECEDPK_01405 6e-39 rpsQ J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HMECEDPK_01406 1.1e-59 rplN J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HMECEDPK_01407 1.4e-47 rplX J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HMECEDPK_01408 1.6e-94 rplE J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HMECEDPK_01409 1.5e-28 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HMECEDPK_01410 1.2e-67 rpsH J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HMECEDPK_01411 2.3e-93 rplF J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HMECEDPK_01412 1.9e-56 rplR J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HMECEDPK_01413 1.7e-79 rpsE J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HMECEDPK_01414 2.5e-23 rpmD J ribosomal protein l30
HMECEDPK_01415 4.4e-58 rplO J binds to the 23S rRNA
HMECEDPK_01416 9.6e-231 secY U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
HMECEDPK_01417 9.2e-121 adk 2.7.4.3 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
HMECEDPK_01418 2.7e-32 infA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HMECEDPK_01419 6e-15 rpmJ J Belongs to the bacterial ribosomal protein bL36 family
HMECEDPK_01420 4e-57 rpsM J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HMECEDPK_01421 9.6e-62 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HMECEDPK_01422 4.8e-171 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HMECEDPK_01423 7.4e-62 rplQ J ribosomal protein l17
HMECEDPK_01426 2.6e-10
HMECEDPK_01427 5.8e-95 V VanZ like family
HMECEDPK_01428 9.2e-15 supH 3.1.3.102, 3.1.3.104 S Sucrose-6F-phosphate phosphohydrolase
HMECEDPK_01429 8.4e-69 supH 3.1.3.102, 3.1.3.104 Q phosphatase activity
HMECEDPK_01430 1.1e-87 G Belongs to the phosphoglycerate mutase family
HMECEDPK_01431 1.3e-199 S hmm pf01594
HMECEDPK_01432 2e-18 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
HMECEDPK_01433 4.6e-138 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
HMECEDPK_01434 4.9e-39 S granule-associated protein
HMECEDPK_01435 5.3e-292 S unusual protein kinase
HMECEDPK_01436 2.6e-15 estA E Lysophospholipase L1 and related esterases
HMECEDPK_01437 3.9e-78 estA E GDSL-like protein
HMECEDPK_01438 1.2e-157 rssA S Phospholipase, patatin family
HMECEDPK_01439 4.3e-83 3.4.16.4 M Belongs to the peptidase S11 family
HMECEDPK_01440 2.3e-26 3.4.16.4 M Belongs to the peptidase S11 family
HMECEDPK_01441 3.4e-22 3.4.16.4 M Belongs to the peptidase S11 family
HMECEDPK_01442 2.9e-21 dacA1 3.4.16.4 M Belongs to the peptidase S11 family
HMECEDPK_01443 1.9e-217 yeaB K Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HMECEDPK_01444 2.9e-127 ung 3.2.2.27 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HMECEDPK_01445 3.7e-235 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
HMECEDPK_01446 1.8e-64 S the current gene model (or a revised gene model) may contain a frame shift
HMECEDPK_01447 5e-38 P membrane protein (DUF2207)
HMECEDPK_01448 6e-185 acoA 1.2.4.1, 1.2.4.4 C Dehydrogenase E1 component
HMECEDPK_01449 3.7e-182 acoB 1.2.4.1, 1.2.4.4 C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
HMECEDPK_01450 1.8e-198 acoC 2.3.1.12 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
HMECEDPK_01451 0.0 lpdA 1.8.1.4 C Dehydrogenase
HMECEDPK_01452 1.6e-83 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
HMECEDPK_01453 8.5e-266 3.5.1.28 NU amidase activity
HMECEDPK_01454 1.9e-37 3.5.1.28 NU amidase activity
HMECEDPK_01455 4.4e-133 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
HMECEDPK_01456 6.1e-66 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
HMECEDPK_01457 1.7e-60 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
HMECEDPK_01458 3.7e-85 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
HMECEDPK_01459 1.5e-33 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
HMECEDPK_01460 1e-165 yclN P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMECEDPK_01461 5.6e-167 fatC P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMECEDPK_01462 6.8e-136 yclP 3.6.3.34 P abc transporter atp-binding protein
HMECEDPK_01463 2e-178 fatB P ABC-type enterochelin transport system, periplasmic component
HMECEDPK_01464 3.2e-153 ycdO P periplasmic lipoprotein involved in iron transport
HMECEDPK_01465 1.6e-232 ycdB P peroxidase
HMECEDPK_01466 3.5e-297 ywbL P COG0672 High-affinity Fe2 Pb2 permease
HMECEDPK_01467 2e-121 tatC U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HMECEDPK_01468 4.6e-25 tatA U protein secretion
HMECEDPK_01469 2.3e-23 L Transposase
HMECEDPK_01470 5.8e-304 malQ 2.4.1.25 GH77 G 4-alpha-glucanotransferase
HMECEDPK_01471 0.0 glgP 2.4.1.1 GT35 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
HMECEDPK_01474 1.5e-186 lplA 6.3.1.20 H Lipoate-protein ligase
HMECEDPK_01475 7e-195 xerS D Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division
HMECEDPK_01476 0.0 pepN 3.4.11.2 E aminopeptidase
HMECEDPK_01477 2.4e-113 phoU P Plays a role in the regulation of phosphate uptake
HMECEDPK_01478 1.7e-139 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
HMECEDPK_01479 5.2e-150 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
HMECEDPK_01480 1.2e-155 pstA P phosphate transport system permease
HMECEDPK_01481 2.5e-156 pstC P probably responsible for the translocation of the substrate across the membrane
HMECEDPK_01482 3.3e-158 pstS P phosphate
HMECEDPK_01483 3e-256 rsmF 2.1.1.176, 2.1.1.178 J NOL1 NOP2 sun family protein
HMECEDPK_01484 5e-142 suhB 3.1.3.25 G Belongs to the inositol monophosphatase superfamily
HMECEDPK_01485 1.9e-43 yktA S Belongs to the UPF0223 family
HMECEDPK_01486 1.4e-71 spxA 1.20.4.1 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
HMECEDPK_01487 5.3e-175 ribF 2.7.1.26, 2.7.7.2 H Belongs to the ribF family
HMECEDPK_01488 4.9e-151 truB 5.4.99.25 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HMECEDPK_01489 2.6e-49 XK27_04775 S hemerythrin HHE cation binding domain
HMECEDPK_01490 1.7e-96 XK27_04775 S hemerythrin HHE cation binding domain
HMECEDPK_01491 1.1e-110 hsdS2 2.1.1.72 V Type I restriction modification DNA specificity domain
HMECEDPK_01492 3.5e-88 tpx 1.11.1.15 O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HMECEDPK_01493 9.3e-62 S haloacid dehalogenase-like hydrolase
HMECEDPK_01494 1.8e-59 Q phosphatase activity
HMECEDPK_01495 4.6e-241 metY 2.5.1.49 E o-acetylhomoserine
HMECEDPK_01496 0.0 pcrA 3.6.4.12 L ATP-dependent DNA helicase
HMECEDPK_01497 1.8e-240 agcS E (Alanine) symporter
HMECEDPK_01498 1.6e-247 mnmE S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HMECEDPK_01499 1.4e-104 yfiF3 K sequence-specific DNA binding
HMECEDPK_01500 9.8e-35 3.1.3.6, 3.1.4.16 F nucleotide catabolic process
HMECEDPK_01501 8.1e-114 sasH 3.1.3.5, 3.6.1.45 F Belongs to the 5'-nucleotidase family
HMECEDPK_01503 1.8e-67 yecS P ABC transporter (Permease
HMECEDPK_01504 8.8e-134 yckB ET Belongs to the bacterial solute-binding protein 3 family
HMECEDPK_01505 8.5e-103 nylA 3.5.1.4 J Belongs to the amidase family
HMECEDPK_01506 1.1e-267 dtpT E transporter
HMECEDPK_01508 1.2e-63 nylA 3.5.1.4 J Belongs to the amidase family
HMECEDPK_01509 7.5e-112 pyrE 2.4.2.10, 4.1.1.23 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HMECEDPK_01510 7e-127 pyrF 4.1.1.23 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
HMECEDPK_01511 5.2e-74 csm6 S Psort location Cytoplasmic, score
HMECEDPK_01512 2.1e-14 csm6 S Psort location Cytoplasmic, score
HMECEDPK_01513 2.2e-204 csm5 L CRISPR-associated RAMP protein, Csm5 family
HMECEDPK_01514 5.8e-166 csm4 L CRISPR-associated RAMP protein, Csm4 family
HMECEDPK_01515 1.1e-116 csm3 L RAMP superfamily
HMECEDPK_01516 5.6e-62 csm2 L Pfam:DUF310
HMECEDPK_01517 0.0 csm1 S CRISPR-associated protein Csm1 family
HMECEDPK_01518 6.8e-133 cas6 S Pfam:DUF2276
HMECEDPK_01519 3.7e-54 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HMECEDPK_01520 1.2e-180 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HMECEDPK_01521 3.2e-175 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
HMECEDPK_01522 1.3e-148 pyrK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )
HMECEDPK_01523 5.9e-97 thiJ 2.7.11.1, 3.5.1.124 S DJ-1 family
HMECEDPK_01524 3.7e-117 S TraX protein
HMECEDPK_01526 3.5e-28 3.4.13.21 I Protein conserved in bacteria
HMECEDPK_01527 3.1e-89 FNV0100 F Belongs to the Nudix hydrolase family
HMECEDPK_01528 3.7e-190
HMECEDPK_01529 2.1e-310 FbpA K RNA-binding protein homologous to eukaryotic snRNP
HMECEDPK_01531 3.9e-15 dinF V Mate efflux family protein
HMECEDPK_01532 3.3e-19 yclQ P ABC-type enterochelin transport system, periplasmic component
HMECEDPK_01533 9.4e-15 yclQ P ABC-type enterochelin transport system, periplasmic component
HMECEDPK_01534 4.1e-118 gph 3.1.3.18 S HAD hydrolase, family IA, variant 1
HMECEDPK_01535 2.6e-143 2.4.2.3 F Phosphorylase superfamily
HMECEDPK_01538 4.5e-79 S Alpha/beta hydrolase of unknown function (DUF915)
HMECEDPK_01539 7.9e-17 S Alpha/beta hydrolase of unknown function (DUF915)
HMECEDPK_01540 6e-08 S Hydrolases of the alpha beta superfamily
HMECEDPK_01541 6.2e-196 adhB 1.1.1.1, 1.1.1.14 E Dehydrogenase
HMECEDPK_01542 2.7e-210 hemH 4.99.1.1, 4.99.1.9 H Catalyzes the ferrous insertion into protoporphyrin IX
HMECEDPK_01543 1.8e-159 czcD P cation diffusion facilitator family transporter
HMECEDPK_01544 9e-98 K Transcriptional regulator, TetR family
HMECEDPK_01545 1.6e-10
HMECEDPK_01546 2.8e-115 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
HMECEDPK_01547 6.4e-104 V ABC transporter (Permease
HMECEDPK_01548 0.0 M family 8
HMECEDPK_01549 2.7e-09
HMECEDPK_01550 5.6e-08
HMECEDPK_01551 5.8e-109 MA20_06410 E LysE type translocator
HMECEDPK_01552 2.7e-26 IQ PFAM AMP-dependent synthetase and ligase
HMECEDPK_01553 3.3e-24 IQ PFAM AMP-dependent synthetase and ligase
HMECEDPK_01554 4e-20
HMECEDPK_01555 1.9e-35
HMECEDPK_01556 1.3e-268 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HMECEDPK_01557 1.6e-58
HMECEDPK_01559 7.4e-31 S Signal peptide protein, YSIRK family
HMECEDPK_01560 1.8e-54 K response regulator
HMECEDPK_01561 1.1e-37 BP1961 P nitric oxide dioxygenase activity
HMECEDPK_01563 3.6e-282 XK27_07020 S Belongs to the UPF0371 family
HMECEDPK_01564 1e-181 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
HMECEDPK_01565 1.5e-160 yvgN C reductase
HMECEDPK_01566 4.2e-96 yoaK S Protein of unknown function (DUF1275)
HMECEDPK_01567 2.2e-111 drgA C Nitroreductase
HMECEDPK_01568 1.1e-231 pts13C G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HMECEDPK_01569 9.5e-158 E Alpha/beta hydrolase of unknown function (DUF915)
HMECEDPK_01570 5.6e-77 ywnA K Transcriptional regulator
HMECEDPK_01571 1.2e-138 1.13.11.2 S glyoxalase
HMECEDPK_01572 5.7e-109 XK27_02070 S nitroreductase
HMECEDPK_01573 6.2e-228 yfnA E amino acid
HMECEDPK_01574 4.8e-25 csbD K CsbD-like
HMECEDPK_01575 8.2e-57 manA 5.3.1.8 G mannose-6-phosphate isomerase
HMECEDPK_01576 1.9e-65 manA 5.3.1.8 G mannose-6-phosphate isomerase
HMECEDPK_01577 1.7e-235 brnQ E Component of the transport system for branched-chain amino acids
HMECEDPK_01578 9.7e-188 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HMECEDPK_01579 4.5e-247 norM V Multidrug efflux pump
HMECEDPK_01580 9.2e-119 pbuX F xanthine permease
HMECEDPK_01581 3.3e-69 pbuX F xanthine permease
HMECEDPK_01582 2e-77 xpt 2.4.2.22, 2.4.2.7 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
HMECEDPK_01583 2e-123 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HMECEDPK_01584 9e-165 T Histidine kinase
HMECEDPK_01585 1.9e-133 macB2 V ABC transporter, ATP-binding protein
HMECEDPK_01586 0.0 V ABC transporter (permease)
HMECEDPK_01587 6e-99 XK27_05000 S Fe-S-cluster oxidoreductase
HMECEDPK_01588 2.6e-30 liaI KT membrane
HMECEDPK_01589 1.4e-15 liaI KT membrane
HMECEDPK_01590 6.1e-26 XK27_09825 V 'abc transporter, ATP-binding protein
HMECEDPK_01591 3.7e-122 S An automated process has identified a potential problem with this gene model
HMECEDPK_01593 4.6e-42 3.6.1.55 F NUDIX domain
HMECEDPK_01594 1.2e-152 mutR K Transcriptional activator, Rgg GadR MutR family
HMECEDPK_01595 0.0 2.7.7.73, 2.7.7.80 E metalloendopeptidase activity
HMECEDPK_01596 6.6e-213 EGP Major facilitator Superfamily
HMECEDPK_01600 5.3e-156 XK27_09825 V abc transporter atp-binding protein
HMECEDPK_01601 1.2e-132 yvfS V ABC-2 type transporter
HMECEDPK_01602 1.5e-184 desK 2.7.13.3 T Histidine kinase
HMECEDPK_01603 4.4e-101 desR K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HMECEDPK_01604 1.6e-59 sdaAB 4.3.1.17 E L-serine dehydratase
HMECEDPK_01605 2.5e-308 hutU 4.2.1.49 E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HMECEDPK_01606 1.6e-205 S Protein of unknown function (DUF917)
HMECEDPK_01607 2.5e-278 hutH 4.3.1.3 E Histidine ammonia-lyase
HMECEDPK_01608 2.3e-103 proWZ P ABC transporter (Permease
HMECEDPK_01609 3.8e-165 proX M ABC transporter, substrate-binding protein, QAT family
HMECEDPK_01610 1.6e-137 proV E abc transporter atp-binding protein
HMECEDPK_01611 2e-88 proW P Binding-protein-dependent transport system inner membrane component
HMECEDPK_01612 1.2e-62 bioY S biotin transmembrane transporter activity
HMECEDPK_01613 3.1e-127 yjjG 3.1.3.102, 3.1.3.104, 3.1.3.5, 3.8.1.2 E hydrolase
HMECEDPK_01614 0.0 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
HMECEDPK_01615 3.4e-277 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HMECEDPK_01616 5.9e-109 L Transposase
HMECEDPK_01617 1.1e-12
HMECEDPK_01618 2.4e-92 pat 2.3.1.183 M acetyltransferase
HMECEDPK_01619 1.1e-198 asd 1.2.1.11 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HMECEDPK_01620 6.6e-173 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HMECEDPK_01621 8.4e-125 rnc 3.1.26.3 J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
HMECEDPK_01622 0.0 smc D Required for chromosome condensation and partitioning
HMECEDPK_01623 9.6e-197 pheS 6.1.1.20 J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HMECEDPK_01624 9.9e-94 paiA 2.3.1.57 K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HMECEDPK_01625 0.0 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HMECEDPK_01628 2e-55 nrdD_1 1.1.98.6, 1.17.4.1 F Ribonucleoside-triphosphate reductase
HMECEDPK_01629 5e-240 XK27_08130 K Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
HMECEDPK_01631 2e-86 S ECF-type riboflavin transporter, S component
HMECEDPK_01632 4.5e-44 pdxK 2.7.1.35 H Belongs to the pyridoxine kinase family
HMECEDPK_01633 3.5e-86 pdxK 2.7.1.35 H Belongs to the pyridoxine kinase family
HMECEDPK_01634 6.7e-83 XK27_01265 S ECF-type riboflavin transporter, S component
HMECEDPK_01635 9.5e-294 yfmM S abc transporter atp-binding protein
HMECEDPK_01636 2.6e-258 noxE P NADH oxidase
HMECEDPK_01637 7e-181 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
HMECEDPK_01638 0.0 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HMECEDPK_01639 1.7e-134 srtA 3.4.22.70 M Sortase (surface protein transpeptidase)
HMECEDPK_01640 1.4e-71 yaeR E COG0346 Lactoylglutathione lyase and related lyases
HMECEDPK_01641 6.9e-165 ypuA S secreted protein
HMECEDPK_01642 3.6e-61 L Transposase (IS116 IS110 IS902 family)
HMECEDPK_01643 1.9e-71 L Transposase (IS116 IS110 IS902 family)
HMECEDPK_01645 1.7e-184 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HMECEDPK_01646 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HMECEDPK_01647 8.5e-34 nrdH O Glutaredoxin
HMECEDPK_01648 0.0 acnA 4.2.1.3 C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HMECEDPK_01649 4.3e-211 citZ 2.3.3.1 C Belongs to the citrate synthase family
HMECEDPK_01650 9.7e-222 icd 1.1.1.42 C Isocitrate dehydrogenase
HMECEDPK_01651 7.9e-39 ptsH G phosphocarrier protein Hpr
HMECEDPK_01652 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HMECEDPK_01657 4.3e-25 S Bacteriocin class II with double-glycine leader peptide
HMECEDPK_01660 4e-133 agrA KT phosphorelay signal transduction system
HMECEDPK_01661 9.9e-239 blpH 2.7.13.3 T protein histidine kinase activity
HMECEDPK_01663 1.6e-236 mesE M Transport protein ComB
HMECEDPK_01664 0.0 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
HMECEDPK_01665 0.0 mdlB V abc transporter atp-binding protein
HMECEDPK_01666 0.0 mdlA V abc transporter atp-binding protein
HMECEDPK_01668 1.7e-93 XK27_09885 V Glycopeptide antibiotics resistance protein
HMECEDPK_01669 3e-223 rlmN 2.1.1.192 J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HMECEDPK_01670 2.3e-72 yutD J protein conserved in bacteria
HMECEDPK_01671 1.3e-270 yunD 3.1.3.5 F Belongs to the 5'-nucleotidase family
HMECEDPK_01673 1.4e-221 cshB 3.6.4.13 JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
HMECEDPK_01674 6.3e-185 mraY 2.7.8.13 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HMECEDPK_01675 0.0 ftsI 3.4.16.4 M penicillin-binding protein
HMECEDPK_01676 8.1e-46 ftsL D cell division protein FtsL
HMECEDPK_01677 3.9e-173 rsmH 2.1.1.199 J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
HMECEDPK_01678 4.7e-65
HMECEDPK_01679 2.7e-52
HMECEDPK_01681 8.7e-33 yhaI J Protein of unknown function (DUF805)
HMECEDPK_01682 4.5e-18 D nuclear chromosome segregation
HMECEDPK_01683 2e-225 proA 1.2.1.41 E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HMECEDPK_01684 1.7e-140 proB 2.7.2.11 E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HMECEDPK_01685 2.2e-285 XK27_00765
HMECEDPK_01686 8.1e-134 ecsA_2 V abc transporter atp-binding protein
HMECEDPK_01687 5.2e-125 S Protein of unknown function (DUF554)
HMECEDPK_01688 0.0 addA 3.6.4.12 L ATP-dependent helicase nuclease subunit A
HMECEDPK_01689 0.0 rexB 3.1.21.3, 3.6.4.12 L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HMECEDPK_01690 2.6e-121 liaI S membrane
HMECEDPK_01691 5.2e-75 XK27_02470 K LytTr DNA-binding domain
HMECEDPK_01692 3.6e-66 KT response to antibiotic
HMECEDPK_01693 1.5e-80 yebC M Membrane
HMECEDPK_01694 2.9e-18 yebC M Membrane
HMECEDPK_01695 4.3e-261 XK27_03190 5.2.1.8 S hydrolases of the HAD superfamily
HMECEDPK_01696 3.8e-173 ansA 3.5.1.1 EJ COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D
HMECEDPK_01698 0.0 recG 3.6.4.12 L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HMECEDPK_01699 1.7e-183 alr 5.1.1.1, 5.1.1.5 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HMECEDPK_01700 4.5e-61 acpS 2.7.6.3, 2.7.8.7, 5.1.1.1 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
HMECEDPK_01701 1.1e-197 aroF 2.5.1.54 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HMECEDPK_01702 2.9e-198 aroF 2.5.1.54 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HMECEDPK_01703 0.0 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
HMECEDPK_01705 3e-189 manA 5.3.1.8 G mannose-6-phosphate isomerase
HMECEDPK_01706 4.1e-172 scrK 2.7.1.2, 2.7.1.4 GK Fructokinase
HMECEDPK_01707 0.0 scrA 2.7.1.208, 2.7.1.211 G pts system
HMECEDPK_01708 5.4e-291 scrB 3.2.1.26 GH32 G invertase
HMECEDPK_01709 7.5e-180 scrR K Transcriptional
HMECEDPK_01710 2.1e-73 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HMECEDPK_01711 3.4e-62 yqhY S protein conserved in bacteria
HMECEDPK_01712 9.3e-98 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HMECEDPK_01713 3.7e-84 comEB 3.5.4.12 F ComE operon protein 2
HMECEDPK_01714 5e-193 pepP 3.4.11.9, 3.4.13.9 E Belongs to the peptidase M24B family
HMECEDPK_01716 1.3e-08 V 'abc transporter, ATP-binding protein
HMECEDPK_01717 1.6e-19 V 'abc transporter, ATP-binding protein
HMECEDPK_01718 2.4e-60 V 'abc transporter, ATP-binding protein
HMECEDPK_01721 0.0 uvrA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HMECEDPK_01722 2e-169 corA P COG0598 Mg2 and Co2 transporters
HMECEDPK_01723 2.6e-123 XK27_01040 S Pfam PF06570
HMECEDPK_01725 9.7e-36 rpsR J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HMECEDPK_01726 2.7e-91 ssb L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
HMECEDPK_01727 3.9e-47 rpsF J Binds together with S18 to 16S ribosomal RNA
HMECEDPK_01728 3.6e-41 XK27_05745
HMECEDPK_01729 2.5e-230 mutY L A G-specific adenine glycosylase
HMECEDPK_01734 0.0 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HMECEDPK_01735 0.0 mutS2 L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
HMECEDPK_01736 1e-93 cvpA S toxin biosynthetic process
HMECEDPK_01737 2.3e-13 zapA D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HMECEDPK_01738 4.7e-160 rnhC 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HMECEDPK_01739 2.6e-112 lepB 3.4.21.89 U Belongs to the peptidase S26 family
HMECEDPK_01740 0.0 recD2 3.1.11.5 L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
HMECEDPK_01741 2e-47 azlD E branched-chain amino acid
HMECEDPK_01742 1.8e-114 azlC E AzlC protein
HMECEDPK_01743 1.9e-186 tsaD 2.3.1.234 O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HMECEDPK_01744 3.7e-73 rimI 2.3.1.128 K This enzyme acetylates the N-terminal alanine of ribosomal protein S18
HMECEDPK_01745 5.6e-121 yeaZ 2.3.1.234 O COG1214, inactive homolog of metal-dependent proteases
HMECEDPK_01746 2.5e-33 ykzG S Belongs to the UPF0356 family
HMECEDPK_01747 0.0 rnjA S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HMECEDPK_01748 2.7e-40 pscB M CHAP domain protein
HMECEDPK_01749 1.5e-263 glnA 6.3.1.2 E glutamine synthetase
HMECEDPK_01750 8.5e-63 glnR K Transcriptional regulator
HMECEDPK_01751 1.3e-87 S Fusaric acid resistance protein-like
HMECEDPK_01752 1.1e-12
HMECEDPK_01753 2e-222 pgk 2.7.2.3, 5.3.1.1 F Belongs to the phosphoglycerate kinase family
HMECEDPK_01754 1e-08 L transposition
HMECEDPK_01755 3e-27 L Integrase core domain protein
HMECEDPK_01756 1.2e-34
HMECEDPK_01757 4.1e-245 der 1.1.1.399, 1.1.1.95 S GTPase that plays an essential role in the late steps of ribosome biogenesis
HMECEDPK_01758 5.2e-167 dnaI L Primosomal protein DnaI
HMECEDPK_01759 6.5e-218 dnaB L Replication initiation and membrane attachment
HMECEDPK_01760 4.7e-82 nrdR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HMECEDPK_01761 2.8e-282 T PhoQ Sensor
HMECEDPK_01762 1.8e-122 T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HMECEDPK_01763 2.1e-91 yceD K metal-binding, possibly nucleic acid-binding protein
HMECEDPK_01764 3.1e-130 rsmG 2.1.1.170 J Ribosomal RNA small subunit methyltransferase G
HMECEDPK_01765 3.4e-242 P COG0168 Trk-type K transport systems, membrane components
HMECEDPK_01766 1.9e-121 ktrA P COG0569 K transport systems, NAD-binding component
HMECEDPK_01767 1.4e-11 ulaG S L-ascorbate 6-phosphate lactonase
HMECEDPK_01768 0.0 tkt 2.2.1.1 G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HMECEDPK_01769 1.2e-149 cbiQ P cobalt transport
HMECEDPK_01770 0.0 ykoD P abc transporter atp-binding protein
HMECEDPK_01771 8e-94 S UPF0397 protein
HMECEDPK_01772 5.5e-158 salL 2.5.1.63, 2.5.1.94 S S-adenosyl-l-methionine hydroxide adenosyltransferase
HMECEDPK_01773 3.9e-210 sstT E Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HMECEDPK_01774 5.2e-98 metI P ABC transporter (Permease
HMECEDPK_01775 1.2e-189 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HMECEDPK_01776 1.4e-62 dapE 3.5.1.18 E succinyl-diaminopimelate desuccinylase activity
HMECEDPK_01777 1.4e-62 dapE 3.5.1.18 E succinyl-diaminopimelate desuccinylase activity
HMECEDPK_01778 4.9e-87 dapE 3.5.1.18 E COG0624, acetylornithine deacetylase succinyl-diaminopimelate desuccinylase and related deacylases
HMECEDPK_01779 3.7e-165 metQ M Belongs to the NlpA lipoprotein family
HMECEDPK_01780 4.5e-152 ET amino acid transport
HMECEDPK_01781 1.6e-131 cbiO P ABC transporter
HMECEDPK_01782 1.1e-136 P cobalt transport protein
HMECEDPK_01783 2.7e-177 cbiM P PDGLE domain
HMECEDPK_01784 4.9e-159 ureD O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
HMECEDPK_01785 9.5e-112 ureG KO Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HMECEDPK_01786 5.3e-130 ureF O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
HMECEDPK_01787 6.6e-78 ureE O enzyme active site formation
HMECEDPK_01788 0.0 ureC 3.5.1.5 E Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family
HMECEDPK_01789 7.8e-54 ureB 3.5.1.5 E Belongs to the urease beta subunit family
HMECEDPK_01790 7.6e-46 ureA 3.5.1.5 E Belongs to the urease gamma subunit family
HMECEDPK_01791 6.8e-95 ureI S AmiS/UreI family transporter
HMECEDPK_01792 9.2e-132 S Domain of unknown function (DUF4173)
HMECEDPK_01793 6.7e-36 S Domain of unknown function (DUF4173)
HMECEDPK_01794 3.7e-51 yhaI L Membrane
HMECEDPK_01795 3.4e-68 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
HMECEDPK_01796 1.1e-36 V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
HMECEDPK_01797 3.4e-62 V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
HMECEDPK_01798 1.9e-33 V protein secretion by the type I secretion system
HMECEDPK_01799 1.6e-160 K sequence-specific DNA binding
HMECEDPK_01800 7e-113 bcrC 3.6.1.27 I Membrane-associated phospholipid phosphatase
HMECEDPK_01801 3.2e-90 ribU U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HMECEDPK_01802 3e-95 trmL 2.1.1.207 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
HMECEDPK_01803 1.3e-246 trkA P Potassium transporter peripheral membrane component
HMECEDPK_01804 1.2e-258 trkH P Cation transport protein
HMECEDPK_01805 1.2e-39 yidD S Could be involved in insertion of integral membrane proteins into the membrane
HMECEDPK_01806 6.1e-140 rluB 5.4.99.19, 5.4.99.21, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
HMECEDPK_01807 3e-99 scpB D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HMECEDPK_01808 9e-122 scpA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HMECEDPK_01809 1.1e-136 xerD L tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site
HMECEDPK_01810 7.8e-85 ykuL S CBS domain
HMECEDPK_01811 3.5e-99 XK27_09740 S Phosphoesterase
HMECEDPK_01812 1.3e-184 rdgB 3.6.1.66, 5.1.1.3 F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HMECEDPK_01813 3.8e-148 murI 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
HMECEDPK_01814 7.6e-36 yneF S UPF0154 protein
HMECEDPK_01815 3.7e-91 K transcriptional regulator
HMECEDPK_01816 9.6e-244 lysA 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
HMECEDPK_01819 8.8e-98 ybhL S Belongs to the BI1 family
HMECEDPK_01820 4.7e-93 XK27_09705 6.1.1.14 S HD superfamily hydrolase
HMECEDPK_01821 2.5e-130 spoU 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HMECEDPK_01822 7e-46 acyP 3.6.1.7 C Belongs to the acylphosphatase family
HMECEDPK_01823 2.9e-165 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HMECEDPK_01824 5.2e-59 L Integrase core domain protein
HMECEDPK_01825 1.6e-77 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
HMECEDPK_01826 0.0 mltG ADL Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HMECEDPK_01827 7.3e-80 XK27_09675 K -acetyltransferase
HMECEDPK_01828 2.6e-255 mpl 6.3.2.4, 6.3.2.45, 6.3.2.8 M Belongs to the MurCDEF family
HMECEDPK_01829 2.5e-23
HMECEDPK_01830 0.0 snf 2.7.11.1 L Superfamily II DNA RNA helicases, SNF2 family'
HMECEDPK_01831 1.1e-296 mapZ D Early cell division protein that marks the future cell division site and supports proper FtsZ ring positioning
HMECEDPK_01832 1.5e-222 rlmL 2.1.1.173, 2.1.1.264 L Belongs to the methyltransferase superfamily
HMECEDPK_01833 2.5e-50 gpsB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
HMECEDPK_01834 3.1e-95 ypsA S Belongs to the UPF0398 family
HMECEDPK_01835 2.5e-109 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
HMECEDPK_01836 0.0 ponA 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
HMECEDPK_01837 4.6e-260 pepC 3.4.22.40 E aminopeptidase
HMECEDPK_01838 1.9e-77 yhaI L Membrane
HMECEDPK_01839 2.1e-151 nadE 6.3.1.5 H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
HMECEDPK_01840 5.7e-280 pncB 6.3.4.21 H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HMECEDPK_01841 1e-139 S COG1073 Hydrolases of the alpha beta superfamily
HMECEDPK_01842 2.6e-76 S thiolester hydrolase activity
HMECEDPK_01844 3.8e-40 K transcriptional
HMECEDPK_01845 0.0 leuS 6.1.1.4 J Belongs to the class-I aminoacyl-tRNA synthetase family
HMECEDPK_01846 3.1e-136 glcR K transcriptional regulator (DeoR family)
HMECEDPK_01847 1.1e-34 cof Q phosphatase activity
HMECEDPK_01848 6e-55 cof Q phosphatase activity
HMECEDPK_01849 4.6e-85 3.1.3.27, 3.1.3.4, 3.1.3.81, 3.6.1.27 I phosphatidate phosphatase activity
HMECEDPK_01850 8.4e-96 nusG K Participates in transcription elongation, termination and antitermination
HMECEDPK_01851 5.7e-25 secE U Belongs to the SecE SEC61-gamma family
HMECEDPK_01852 0.0 pbp2A 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
HMECEDPK_01853 1.2e-165 rluA 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
HMECEDPK_01854 9.9e-55 S TM2 domain
HMECEDPK_01855 4.7e-43

eggNOG-mapper v2 (Database: eggNOG v5.0, Jul. 2018 release)