ORF_ID e_value Gene_name EC_number CAZy COGs Description
HEPMHJLG_00001 2.8e-134 fasA KT Response regulator of the LytR AlgR family
HEPMHJLG_00002 4.5e-244 fasC 2.7.13.3 T protein histidine kinase activity
HEPMHJLG_00003 7.1e-210 hpk9 2.7.13.3 T protein histidine kinase activity
HEPMHJLG_00004 3.7e-157 hpk9 2.7.13.3 T protein histidine kinase activity
HEPMHJLG_00005 6.7e-232 2.7.13.3 T signal transduction protein with a C-terminal ATPase domain
HEPMHJLG_00006 3.5e-274 gltX 6.1.1.17, 6.1.1.24 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HEPMHJLG_00007 0.0 amiA E ABC transporter, substrate-binding protein, family 5
HEPMHJLG_00008 1.4e-119 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
HEPMHJLG_00009 3.7e-70 rplK J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HEPMHJLG_00010 1.2e-50 S Protein of unknown function (DUF3397)
HEPMHJLG_00011 9.2e-89 cah 4.2.1.1 P Reversible hydration of carbon dioxide
HEPMHJLG_00012 3.1e-127 WQ51_05710 S Mitochondrial biogenesis AIM24
HEPMHJLG_00013 1.1e-226 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HEPMHJLG_00014 3.3e-73 3.5.1.19 Q hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
HEPMHJLG_00015 2e-79 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
HEPMHJLG_00016 6.3e-108 XK27_09620 S FMN reductase (NADPH) activity
HEPMHJLG_00017 7.9e-230 XK27_09615 C reductase
HEPMHJLG_00018 4.8e-140 fnt P Formate nitrite transporter
HEPMHJLG_00019 3.9e-96 XK27_08585 S Psort location CytoplasmicMembrane, score
HEPMHJLG_00020 3.7e-185 gpsA 1.1.1.94 I Glycerol-3-phosphate dehydrogenase
HEPMHJLG_00021 6.1e-171 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
HEPMHJLG_00022 1.8e-116 gluP 3.4.21.105 O membrane protein (homolog of Drosophila rhomboid)
HEPMHJLG_00023 1.6e-94 ygfA 6.3.3.2 H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HEPMHJLG_00024 6.7e-220 hipO 3.5.1.47 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
HEPMHJLG_00025 5.3e-58 dapD 2.3.1.117, 2.3.1.89 E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
HEPMHJLG_00026 1.1e-133 S HAD hydrolase, family IA, variant
HEPMHJLG_00027 8.6e-156 rrmA 2.1.1.187 Q methyltransferase
HEPMHJLG_00031 6.6e-90 tadA 3.5.4.1, 3.5.4.33 FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
HEPMHJLG_00032 6.6e-66 ssb_2 L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
HEPMHJLG_00033 8.3e-37 yeeD O sulfur carrier activity
HEPMHJLG_00034 5.8e-186 yeeE S Sulphur transport
HEPMHJLG_00035 1.1e-112 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HEPMHJLG_00036 1e-53 ytpP 2.7.1.180, 5.3.4.1 CO Thioredoxin
HEPMHJLG_00037 2e-08 XK27_10305 S Domain of unknown function (DUF4651)
HEPMHJLG_00038 5.9e-202 pepA 3.4.11.7 G COG1363 Cellulase M and related proteins
HEPMHJLG_00039 9.7e-130 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HEPMHJLG_00040 1.8e-100 S CAAX amino terminal protease family protein
HEPMHJLG_00042 7.3e-110 V CAAX protease self-immunity
HEPMHJLG_00043 8.8e-27 lanR K sequence-specific DNA binding
HEPMHJLG_00044 4.1e-220 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HEPMHJLG_00045 3.2e-175 ytxK 2.1.1.72 L DNA methylase
HEPMHJLG_00046 2e-12 comGF U Putative Competence protein ComGF
HEPMHJLG_00047 4.5e-71 comGF U Competence protein ComGF
HEPMHJLG_00048 3.1e-15 NU Type II secretory pathway pseudopilin
HEPMHJLG_00049 6.4e-70 cglD NU Competence protein
HEPMHJLG_00050 2.2e-43 comGC U Required for transformation and DNA binding
HEPMHJLG_00051 4.1e-142 cglB U protein transport across the cell outer membrane
HEPMHJLG_00052 1.1e-175 comGA NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HEPMHJLG_00053 2.9e-68 S cog cog4699
HEPMHJLG_00054 0.0 rpoC 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HEPMHJLG_00055 0.0 rpoB 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HEPMHJLG_00056 0.0 pbp1B 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
HEPMHJLG_00057 4.2e-239 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HEPMHJLG_00058 2e-97 XK27_07830 2.3.1.128 J Acetyltransferase GNAT Family
HEPMHJLG_00059 1.1e-231 ytoI K transcriptional regulator containing CBS domains
HEPMHJLG_00060 1.1e-166 map 3.4.11.18 E Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed
HEPMHJLG_00061 3.7e-163 rbn E Belongs to the UPF0761 family
HEPMHJLG_00062 1.7e-85 ccl S cog cog4708
HEPMHJLG_00063 0.0 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HEPMHJLG_00064 4e-184 yegS 2.7.1.107 I Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
HEPMHJLG_00065 4.8e-174 yfjR K regulation of single-species biofilm formation
HEPMHJLG_00067 8.3e-71 S QueT transporter
HEPMHJLG_00068 8.5e-156 xth 3.1.11.2 L exodeoxyribonuclease III
HEPMHJLG_00070 2.9e-17 yjdB S Domain of unknown function (DUF4767)
HEPMHJLG_00071 6.7e-167 tehB 2.1.1.265 PQ tellurite resistance protein tehb
HEPMHJLG_00072 2.4e-189 O protein import
HEPMHJLG_00073 2.1e-129 agrA KT phosphorelay signal transduction system
HEPMHJLG_00074 7.8e-198 2.7.13.3 T GHKL domain
HEPMHJLG_00076 2.4e-43 rpsP J Belongs to the bacterial ribosomal protein bS16 family
HEPMHJLG_00077 1.5e-36 ylqC L Belongs to the UPF0109 family
HEPMHJLG_00078 3.5e-233 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
HEPMHJLG_00079 0.0 ydaO E amino acid
HEPMHJLG_00080 7.7e-100 folE 3.5.4.16 F gtp cyclohydrolase
HEPMHJLG_00081 5e-145 folP 2.5.1.15, 2.7.6.3 H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HEPMHJLG_00082 1.7e-289 amy 3.2.1.1 GH13 G Belongs to the glycosyl hydrolase 13 family
HEPMHJLG_00083 4.5e-61 folB 1.13.11.81, 2.5.1.15, 2.7.6.3, 4.1.2.25, 5.1.99.8 H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HEPMHJLG_00084 4.1e-81 folK 2.7.6.3, 4.1.2.25 H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HEPMHJLG_00085 9.5e-169 murB 1.3.1.98 M cell wall formation
HEPMHJLG_00086 2.6e-211 potA 3.6.3.30, 3.6.3.31 P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
HEPMHJLG_00087 4.1e-139 potB P ABC-type spermidine putrescine transport system, permease component I
HEPMHJLG_00088 2.3e-131 potC P ABC-type spermidine putrescine transport system, permease component II
HEPMHJLG_00089 2.6e-205 potD P spermidine putrescine ABC transporter
HEPMHJLG_00090 1.9e-145 XK27_08050 O HflC and HflK could regulate a protease
HEPMHJLG_00091 1.8e-71 gloA 4.4.1.5 E Lactoylglutathione lyase
HEPMHJLG_00092 2.6e-158 GK ROK family
HEPMHJLG_00093 1.9e-208 serC 2.6.1.52 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HEPMHJLG_00094 1e-104 wecD M Acetyltransferase (GNAT) domain
HEPMHJLG_00095 7.4e-222 serA 1.1.1.399, 1.1.1.95 EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HEPMHJLG_00096 7.8e-72 ogt 2.1.1.63, 3.2.2.20 L methylated-DNA-[protein]-cysteine S-methyltransferase activity
HEPMHJLG_00097 1e-57 arsC 1.20.4.1 P Belongs to the ArsC family
HEPMHJLG_00099 5e-186 femA 2.3.2.10, 2.3.2.16 V FemAB family
HEPMHJLG_00100 2.4e-16 atpE C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HEPMHJLG_00101 9e-122 atpB C it plays a direct role in the translocation of protons across the membrane
HEPMHJLG_00102 1.6e-77 atpF C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HEPMHJLG_00103 1e-85 atpH C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HEPMHJLG_00104 1e-279 atpA 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HEPMHJLG_00105 4.8e-157 atpG C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HEPMHJLG_00106 7.9e-263 atpD 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HEPMHJLG_00107 2.6e-68 atpC C Produces ATP from ADP in the presence of a proton gradient across the membrane
HEPMHJLG_00108 1.5e-215 ftsW D Belongs to the SEDS family
HEPMHJLG_00109 1.6e-224 tuf J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HEPMHJLG_00110 4.6e-140 glnQ 3.6.3.21 E abc transporter atp-binding protein
HEPMHJLG_00111 3.8e-128 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HEPMHJLG_00112 3.2e-220 vicK 2.7.13.3 T Histidine kinase
HEPMHJLG_00113 1.3e-153 vicX 3.1.26.11 S Metal-dependent hydrolases of the beta-lactamase superfamily I
HEPMHJLG_00114 8.7e-57 S Protein of unknown function (DUF454)
HEPMHJLG_00115 4.1e-207 murM 2.3.2.10, 2.3.2.16 V protein involved in methicillin resistance
HEPMHJLG_00116 2e-146 yidA S hydrolases of the HAD superfamily
HEPMHJLG_00117 1.7e-159 XK27_00115 2.3.1.128 K Acetyltransferase GNAT family
HEPMHJLG_00118 4.4e-135 XK27_00120 2.4.2.3 F Phosphorylase superfamily
HEPMHJLG_00119 4.5e-67 ywiB S Domain of unknown function (DUF1934)
HEPMHJLG_00120 0.0 pacL 3.6.3.8 P cation transport ATPase
HEPMHJLG_00121 3.1e-133 nfrA 1.5.1.38, 1.5.1.39 C nitroreductase
HEPMHJLG_00122 1e-156 yjjH S Calcineurin-like phosphoesterase
HEPMHJLG_00123 5.1e-204 queG 1.17.99.6 C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HEPMHJLG_00124 5.7e-183 prfB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HEPMHJLG_00125 3.2e-124 ftsE D cell division ATP-binding protein FtsE
HEPMHJLG_00126 7.3e-164 ftsX D Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation
HEPMHJLG_00127 1.9e-91 mutX 3.6.1.55 F NTP pyrophosphohydrolases including oxidative damage repair enzymes
HEPMHJLG_00128 4.3e-177 yubA S permease
HEPMHJLG_00129 4.4e-225 G COG0457 FOG TPR repeat
HEPMHJLG_00130 1.3e-96 lepB 3.4.21.89 U Belongs to the peptidase S26 family
HEPMHJLG_00131 0.0 lytC 3.4.17.14, 3.5.1.28 M N-acetylmuramoyl-L-alanine amidase
HEPMHJLG_00132 1.5e-233 pepT 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
HEPMHJLG_00133 8.6e-87 ebsA S Family of unknown function (DUF5322)
HEPMHJLG_00134 2.4e-17 M LysM domain
HEPMHJLG_00135 1.6e-120 cmk 1.17.7.4, 2.5.1.19, 2.7.1.26, 2.7.4.25, 2.7.7.2, 6.3.2.1 F Belongs to the cytidylate kinase family. Type 1 subfamily
HEPMHJLG_00136 5.6e-84 infC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HEPMHJLG_00137 8.1e-28 rpmI J Belongs to the bacterial ribosomal protein bL35 family
HEPMHJLG_00138 1.5e-56 rplT J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HEPMHJLG_00139 5.5e-83 XK27_03610 K Gnat family
HEPMHJLG_00140 1.9e-92 yybC
HEPMHJLG_00141 4.9e-27 dmpI 5.3.2.6 G Belongs to the 4-oxalocrotonate tautomerase family
HEPMHJLG_00142 1.9e-272 pepV 3.5.1.18 E Dipeptidase
HEPMHJLG_00143 9.1e-112 ung2 3.2.2.27 L Uracil-DNA glycosylase
HEPMHJLG_00144 2e-240 cps4A K Cell envelope-like function transcriptional attenuator common domain protein
HEPMHJLG_00145 6.8e-133 cpsB 3.1.3.48 GM Capsular polysaccharide biosynthesis protein
HEPMHJLG_00146 7.2e-116 cps4C M biosynthesis protein
HEPMHJLG_00147 6.1e-113 cpsD D COG0489 ATPases involved in chromosome partitioning
HEPMHJLG_00148 4.8e-257 cpsE M Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
HEPMHJLG_00149 1.7e-126 tagA 2.4.1.187 GT26 M Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid
HEPMHJLG_00150 7.4e-160 licD M LICD family
HEPMHJLG_00151 2e-163 S Glycosyl transferase family 2
HEPMHJLG_00152 4.4e-205 M glycosyl transferase group 1
HEPMHJLG_00153 4e-85
HEPMHJLG_00154 2.7e-171 S glycosyl transferase family 2
HEPMHJLG_00155 1.3e-204 mnaA 5.1.3.14 G Belongs to the UDP-N-acetylglucosamine 2-epimerase family
HEPMHJLG_00156 0.0 M Polysaccharide biosynthesis protein
HEPMHJLG_00157 1.5e-245 S Polysaccharide biosynthesis protein
HEPMHJLG_00158 2.1e-143 modF 3.6.3.21, 3.6.3.34 P abc transporter atp-binding protein
HEPMHJLG_00159 3.8e-238 hlyX S COG1253 Hemolysins and related proteins containing CBS domains
HEPMHJLG_00160 5.2e-08 MU outer membrane autotransporter barrel domain protein
HEPMHJLG_00161 3.9e-158 pflA 1.97.1.4 C Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HEPMHJLG_00163 9e-75 XK27_03180 T universal stress protein
HEPMHJLG_00164 2.9e-237 alaA 2.6.1.2, 2.6.1.66 E Aminotransferase
HEPMHJLG_00165 8.1e-140 codY K DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HEPMHJLG_00166 2e-100 pncA Q isochorismatase
HEPMHJLG_00167 2.9e-292 ascB 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
HEPMHJLG_00168 1.4e-41 tagE 2.4.1.52 GT4 M transferase activity, transferring glycosyl groups
HEPMHJLG_00169 1.8e-47 gatC 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HEPMHJLG_00170 7.7e-269 gatA 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
HEPMHJLG_00171 3e-273 gatB 6.1.1.12, 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HEPMHJLG_00172 9.3e-65
HEPMHJLG_00173 6.3e-152 yicL EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
HEPMHJLG_00174 5.1e-98 yqeG S hydrolase of the HAD superfamily
HEPMHJLG_00175 1.7e-212 yqeH S in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis
HEPMHJLG_00176 1.9e-47 yhbY J RNA-binding protein
HEPMHJLG_00177 1.2e-117 nadD 2.7.7.18, 3.6.1.55 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HEPMHJLG_00178 9.2e-104 nadD 2.7.6.3, 2.7.7.18 H HD superfamily hydrolase involved in NAD metabolism
HEPMHJLG_00179 2.7e-58 rsfS J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
HEPMHJLG_00180 8.4e-139 yqeM Q Methyltransferase domain protein
HEPMHJLG_00181 6.5e-113 S AAA ATPase domain
HEPMHJLG_00182 8.5e-196 ylbM S Belongs to the UPF0348 family
HEPMHJLG_00183 3.4e-39 yefM 2.3.1.15 D Antitoxin component of a toxin-antitoxin (TA) module
HEPMHJLG_00184 1.6e-44 yoeB S Addiction module toxin, Txe YoeB family
HEPMHJLG_00186 0.0 clpL O ATP-dependent Clp protease ATP-binding subunit
HEPMHJLG_00188 2e-101
HEPMHJLG_00191 3.3e-09
HEPMHJLG_00192 1e-72 hit FG Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
HEPMHJLG_00193 1.3e-131 ecsA V abc transporter atp-binding protein
HEPMHJLG_00194 4.9e-177 ecsB U Bacterial ABC transporter protein EcsB
HEPMHJLG_00195 7.1e-152 ytmP 2.7.1.89 M Phosphotransferase
HEPMHJLG_00196 3.1e-121 trmB 2.1.1.297, 2.1.1.33 J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
HEPMHJLG_00198 4.7e-224 ytfP S Flavoprotein
HEPMHJLG_00199 0.0 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
HEPMHJLG_00200 8.2e-63 XK27_02560 S cog cog2151
HEPMHJLG_00201 9.1e-42 WQ51_02910 S Protein of unknown function, DUF536
HEPMHJLG_00202 6.4e-105 dnaQ 2.7.7.7 L DNA polymerase III
HEPMHJLG_00203 1.6e-126 K transcriptional regulator, MerR family
HEPMHJLG_00204 0.0 V ABC transporter (Permease
HEPMHJLG_00205 7.3e-124 V abc transporter atp-binding protein
HEPMHJLG_00207 1.2e-43 yaaK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HEPMHJLG_00208 9.2e-175 L Integrase
HEPMHJLG_00211 1.8e-47
HEPMHJLG_00212 0.0 ctpE P E1-E2 ATPase
HEPMHJLG_00213 4.3e-59
HEPMHJLG_00214 2.1e-19 S Bacteriocin (Lactococcin_972)
HEPMHJLG_00215 0.0 S bacteriocin-associated integral membrane protein
HEPMHJLG_00216 3.5e-120 yujD V lipoprotein transporter activity
HEPMHJLG_00217 1.2e-40 pchB 2.5.1.19, 4.2.1.10, 4.2.99.21, 5.4.99.5 E Chorismate mutase type II
HEPMHJLG_00218 2.8e-257 trpE 4.1.3.27 EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HEPMHJLG_00219 2.7e-105 trpG 2.4.2.18, 2.6.1.85, 4.1.3.27 EH anthranilate
HEPMHJLG_00220 5.6e-178 trpD 2.4.2.18, 4.1.3.27 F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HEPMHJLG_00221 9.4e-133 trpC 4.1.1.48, 5.3.1.24 E Belongs to the TrpC family
HEPMHJLG_00222 1.4e-96 trpF 4.1.1.48, 4.2.1.160, 4.2.1.20, 5.3.1.24 E belongs to the TrpF family
HEPMHJLG_00223 6.5e-229 trpB 4.2.1.20, 5.3.1.24 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HEPMHJLG_00224 2.3e-142 trpA 4.2.1.20 E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
HEPMHJLG_00225 7.2e-177 EGP Major facilitator Superfamily
HEPMHJLG_00226 8.8e-72 copY K negative regulation of transcription, DNA-templated
HEPMHJLG_00227 0.0 copA 3.6.3.54 P P-type ATPase
HEPMHJLG_00228 2.7e-31 copZ 2.7.7.77 P Heavy metal-associated domain protein
HEPMHJLG_00229 1.2e-191 ddl 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
HEPMHJLG_00230 2.5e-113 papP P ABC transporter (Permease
HEPMHJLG_00231 3e-106 P ABC transporter (Permease
HEPMHJLG_00232 9.9e-135 glnQ 3.6.3.21 E abc transporter atp-binding protein
HEPMHJLG_00233 2.8e-154 cjaA ET ABC transporter substrate-binding protein
HEPMHJLG_00237 9.2e-256 murF 6.3.2.10 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
HEPMHJLG_00238 3.1e-116 ywaF S Integral membrane protein (intg_mem_TP0381)
HEPMHJLG_00239 2.3e-300 prfC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HEPMHJLG_00240 5.8e-95 thiT S Thiamine transporter
HEPMHJLG_00241 2.1e-61 yjqA S Bacterial PH domain
HEPMHJLG_00242 1.6e-152 corA P CorA-like protein
HEPMHJLG_00243 2.2e-245 cshA 3.6.4.13 JKL DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
HEPMHJLG_00244 7e-43 yazA L endonuclease containing a URI domain
HEPMHJLG_00245 5.5e-141 yabB 2.1.1.223 L Methyltransferase
HEPMHJLG_00246 1.2e-156 nodB3 G deacetylase
HEPMHJLG_00247 9.8e-143 plsC 2.3.1.51 I Acyltransferase
HEPMHJLG_00248 1.1e-92 comEA L COG1555 DNA uptake protein and related DNA-binding proteins
HEPMHJLG_00249 0.0 comEC S Competence protein ComEC
HEPMHJLG_00250 1e-232 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HEPMHJLG_00251 1.7e-102 GBS0088 J protein conserved in bacteria
HEPMHJLG_00252 1.7e-133 mvk 1.1.1.88, 2.3.3.10, 2.7.1.36 I mevalonate kinase
HEPMHJLG_00253 2.4e-170 mvaD 4.1.1.33 I diphosphomevalonate decarboxylase
HEPMHJLG_00254 4.6e-164 mvaK2 2.7.1.36, 2.7.1.43, 2.7.4.2 I phosphomevalonate kinase
HEPMHJLG_00255 1.8e-184 fni 1.1.1.88, 5.3.3.2 C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
HEPMHJLG_00256 0.0 mgtA 3.6.3.2 P COG0474 Cation transport ATPase
HEPMHJLG_00257 2.6e-242 glmU 2.3.1.157, 2.7.7.23 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HEPMHJLG_00258 7.7e-97 nudF 3.6.1.13 L AdP-ribose pyrophosphatase
HEPMHJLG_00259 2e-26
HEPMHJLG_00260 1.2e-118 mtnN 3.2.2.9 E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HEPMHJLG_00261 0.0 U protein secretion
HEPMHJLG_00262 2.6e-191 dgs 2.4.1.208 GT4 M Glycosyltransferase, group 1 family protein
HEPMHJLG_00263 2.6e-247 mgs 2.4.1.337 GT4 M Glycosyltransferase, group 1 family protein
HEPMHJLG_00264 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HEPMHJLG_00265 1.2e-158 S hydrolases or acyltransferases (alpha beta hydrolase superfamily)
HEPMHJLG_00266 1.1e-200 S Protein of unknown function (DUF3114)
HEPMHJLG_00267 4.1e-29 pspC KT PspC domain protein
HEPMHJLG_00268 5.2e-119 yqfA K protein, Hemolysin III
HEPMHJLG_00269 3e-78 K hmm pf08876
HEPMHJLG_00270 4.7e-230 mvaA 1.1.1.34, 1.1.1.88, 2.3.1.9 C Belongs to the HMG-CoA reductase family
HEPMHJLG_00271 7.9e-216 mvaS 2.3.3.10 I synthase
HEPMHJLG_00272 5.9e-168 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HEPMHJLG_00273 9.6e-94 folA 1.5.1.3, 1.5.1.47, 2.1.1.45, 3.5.4.12 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HEPMHJLG_00274 9.7e-22
HEPMHJLG_00275 2.6e-225 clpX O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HEPMHJLG_00276 1.1e-109 engB D Necessary for normal cell division and for the maintenance of normal septation
HEPMHJLG_00277 1.8e-251 mmuP E amino acid
HEPMHJLG_00278 1.1e-178 mmuM 1.5.1.20, 2.1.1.10 H Homocysteine
HEPMHJLG_00279 2.2e-30 S Domain of unknown function (DUF1912)
HEPMHJLG_00280 4.8e-13 L Helix-hairpin-helix DNA-binding motif class 1
HEPMHJLG_00281 1.8e-108 plsY 2.3.1.15, 3.5.1.104 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
HEPMHJLG_00282 0.0 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HEPMHJLG_00284 0.0 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HEPMHJLG_00285 2.6e-199 ilvE 2.6.1.42 E Aminotransferase
HEPMHJLG_00286 4.8e-16 S Protein of unknown function (DUF2969)
HEPMHJLG_00289 2.5e-204 rpsA 1.17.7.4 J ribosomal protein S1
HEPMHJLG_00292 1.9e-107 S Domain of Unknown Function with PDB structure (DUF3862)
HEPMHJLG_00293 9.5e-175 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HEPMHJLG_00294 5.5e-217 araT 2.6.1.1 E Aminotransferase
HEPMHJLG_00295 6.1e-140 recO L Involved in DNA repair and RecF pathway recombination
HEPMHJLG_00296 9.5e-181 plsX 2.3.1.15 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
HEPMHJLG_00297 1.8e-29 acpP1 IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEPMHJLG_00298 8.9e-130 purC 4.1.1.21, 4.3.2.2, 6.3.2.6 F Belongs to the SAICAR synthetase family
HEPMHJLG_00299 0.0 purL 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HEPMHJLG_00300 8.4e-276 purF 2.4.2.14 F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HEPMHJLG_00301 1.4e-189 purM 6.3.3.1, 6.3.4.13 F Phosphoribosylformylglycinamidine cyclo-ligase
HEPMHJLG_00302 6.8e-101 purN 2.1.2.2 F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HEPMHJLG_00303 2.8e-293 purH 2.1.2.3, 3.5.4.10 F Bifunctional purine biosynthesis protein PurH
HEPMHJLG_00304 3e-237 purD 6.3.4.13 F Belongs to the GARS family
HEPMHJLG_00305 4.5e-80 purE 5.4.99.18 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HEPMHJLG_00306 2.3e-201 purK 6.3.4.18 F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HEPMHJLG_00307 1.1e-175 1.1.1.169 H Ketopantoate reductase
HEPMHJLG_00308 6.6e-34
HEPMHJLG_00309 9.6e-135 J Domain of unknown function (DUF4041)
HEPMHJLG_00310 2.5e-247 purB 4.3.2.2 F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HEPMHJLG_00311 0.0 argS 6.1.1.19 J Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
HEPMHJLG_00312 3.1e-69 argR K Regulates arginine biosynthesis genes
HEPMHJLG_00313 1.9e-56 ymcA 3.6.3.21 S Belongs to the UPF0342 family
HEPMHJLG_00314 0.0 mutS L that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HEPMHJLG_00315 1.9e-77 S Protein of unknown function (DUF3021)
HEPMHJLG_00316 2.4e-69 K LytTr DNA-binding domain
HEPMHJLG_00318 0.0 mutL L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HEPMHJLG_00320 3e-102 ruvA 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
HEPMHJLG_00321 2.3e-104 tag 3.2.2.20 L 3-methyladenine DNA glycosylase
HEPMHJLG_00322 4e-229 cinA 3.5.1.42 S Belongs to the CinA family
HEPMHJLG_00323 1e-204 recA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HEPMHJLG_00324 3.9e-66 spxA_2 1.20.4.1 P Belongs to the ArsC family
HEPMHJLG_00326 3.3e-117 nudL L hydrolase
HEPMHJLG_00327 9.1e-53 K transcriptional regulator, PadR family
HEPMHJLG_00328 1.9e-61 XK27_06920 S Protein of unknown function (DUF1700)
HEPMHJLG_00329 3.7e-106 S Putative adhesin
HEPMHJLG_00330 1.7e-156 XK27_06930 V domain protein
HEPMHJLG_00331 4.6e-94 XK27_06935 K transcriptional regulator
HEPMHJLG_00332 3.8e-52 ypaA M Membrane
HEPMHJLG_00333 1.1e-10
HEPMHJLG_00334 5.8e-109 rpsD J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HEPMHJLG_00335 1.8e-47 veg S Biofilm formation stimulator VEG
HEPMHJLG_00336 1e-246 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
HEPMHJLG_00337 2.2e-73 rplI J binds to the 23S rRNA
HEPMHJLG_00338 0.0 yybT T signaling protein consisting of a modified GGDEF domain and a DHH domain
HEPMHJLG_00339 0.0 gidA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
HEPMHJLG_00340 4.2e-99 yvbG U UPF0056 membrane protein
HEPMHJLG_00341 2.8e-218 mnmA 2.8.1.13 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
HEPMHJLG_00342 0.0 S Bacterial membrane protein, YfhO
HEPMHJLG_00343 3.2e-63 isaA GH23 M Immunodominant staphylococcal antigen A
HEPMHJLG_00344 3.3e-58 lytE M LysM domain protein
HEPMHJLG_00345 1.7e-132 ecfT P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HEPMHJLG_00346 3.6e-154 ecfA2 3.6.3.55 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HEPMHJLG_00347 3.1e-150 ecfA1 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HEPMHJLG_00348 4.1e-90 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HEPMHJLG_00349 8.3e-130 S sequence-specific DNA binding
HEPMHJLG_00350 9.5e-239 ymfH S Peptidase M16
HEPMHJLG_00351 4.2e-231 ymfF S Peptidase M16
HEPMHJLG_00352 5.8e-59 yaaA S S4 domain protein YaaA
HEPMHJLG_00353 1.2e-202 recF L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HEPMHJLG_00354 8.1e-274 guaB 1.1.1.205 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
HEPMHJLG_00355 1.2e-191 trpS 6.1.1.2 J Tryptophanyl-tRNA synthetase
HEPMHJLG_00356 7.1e-153 yvjA S membrane
HEPMHJLG_00357 1.1e-305 ybiT S abc transporter atp-binding protein
HEPMHJLG_00358 0.0 XK27_10405 S Bacterial membrane protein YfhO
HEPMHJLG_00359 3.6e-222 sip L Belongs to the 'phage' integrase family
HEPMHJLG_00360 1.2e-28 S MerR HTH family regulatory protein
HEPMHJLG_00361 4.6e-201
HEPMHJLG_00362 1.5e-95 D ftsk spoiiie
HEPMHJLG_00368 4.1e-48 K DNA-binding protein
HEPMHJLG_00369 2.5e-80
HEPMHJLG_00370 6.7e-19 rpmG J Belongs to the bacterial ribosomal protein bL33 family
HEPMHJLG_00371 1.5e-25 rpmF J Belongs to the bacterial ribosomal protein bL32 family
HEPMHJLG_00372 3.3e-219 metE 2.1.1.14 E Methionine synthase
HEPMHJLG_00373 1.1e-240 2.7.1.201, 2.7.1.208, 2.7.1.211 G pts system
HEPMHJLG_00374 2.5e-239 hisS 6.1.1.21 J histidyl-tRNA synthetase
HEPMHJLG_00376 0.0 aspS 6.1.1.12 J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
HEPMHJLG_00377 2.7e-166 XK27_01785 S cog cog1284
HEPMHJLG_00378 8.3e-120 yaaA S Belongs to the UPF0246 family
HEPMHJLG_00382 6.2e-120 yoaK S Protein of unknown function (DUF1275)
HEPMHJLG_00383 4.8e-85 rlmH 2.1.1.177 J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HEPMHJLG_00384 9.2e-207 htrA 3.4.21.107 O Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain'
HEPMHJLG_00385 1.9e-133 parB K Belongs to the ParB family
HEPMHJLG_00386 1e-254 dnaA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HEPMHJLG_00387 7.2e-198 dnaN 2.7.7.7 L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
HEPMHJLG_00388 1.1e-29 yyzM S Protein conserved in bacteria
HEPMHJLG_00389 1.1e-203 ychF J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
HEPMHJLG_00390 2e-103 pth 3.1.1.29 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
HEPMHJLG_00391 0.0 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HEPMHJLG_00392 6.3e-39 yabO J Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
HEPMHJLG_00393 3e-60 divIC D Septum formation initiator
HEPMHJLG_00395 4.5e-236 XK27_09285 3.5.2.6 V Beta-lactamase enzyme family
HEPMHJLG_00396 1.1e-236 tilS 2.4.2.8, 6.3.4.19 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
HEPMHJLG_00397 2e-97 hpt 2.4.2.8, 6.3.4.19 F Belongs to the purine pyrimidine phosphoribosyltransferase family
HEPMHJLG_00398 0.0 ftsH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEPMHJLG_00401 0.0 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
HEPMHJLG_00402 0.0 pepO 3.4.24.71 O Peptidase family M13
HEPMHJLG_00403 0.0 treC 3.2.1.93 GH13 G COG0366 Glycosidases
HEPMHJLG_00404 2.1e-288 treB 2.7.1.201, 2.7.1.208, 2.7.1.211 G pts system
HEPMHJLG_00405 1.7e-53 treB 2.7.1.201 G pts system
HEPMHJLG_00406 2.3e-125 treR K trehalose operon
HEPMHJLG_00407 4.3e-95 ywlG S Belongs to the UPF0340 family
HEPMHJLG_00410 8.2e-165 fba 4.1.2.13, 4.1.2.29 G aldolase
HEPMHJLG_00412 8.1e-238 6.3.2.2 H gamma-glutamylcysteine synthetase
HEPMHJLG_00414 8.3e-290 ahpF O alkyl hydroperoxide reductase
HEPMHJLG_00415 1.1e-106 ahpC 1.11.1.15 O alkyl hydroperoxide reductase
HEPMHJLG_00416 7.4e-138 rpsB J Belongs to the universal ribosomal protein uS2 family
HEPMHJLG_00417 1e-182 tsf J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HEPMHJLG_00418 1.2e-82 S Putative small multi-drug export protein
HEPMHJLG_00419 4.8e-76 ctsR K Belongs to the CtsR family
HEPMHJLG_00420 0.0 clpC O Belongs to the ClpA ClpB family
HEPMHJLG_00421 2e-233 dacA 3.4.16.4 M Belongs to the peptidase S11 family
HEPMHJLG_00422 3e-229 dacA 3.4.16.4 M Belongs to the peptidase S11 family
HEPMHJLG_00423 0.0 pnp 2.7.7.8 J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
HEPMHJLG_00424 1.5e-138 S SseB protein N-terminal domain
HEPMHJLG_00425 3.3e-112 cysE 2.3.1.30 E serine acetyltransferase
HEPMHJLG_00427 8.1e-257 cysS 6.1.1.16, 6.3.1.13 J Belongs to the class-I aminoacyl-tRNA synthetase family
HEPMHJLG_00428 2.7e-67 mrnC J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HEPMHJLG_00430 2.8e-134 trmH 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEPMHJLG_00431 2.7e-91 yacP S RNA-binding protein containing a PIN domain
HEPMHJLG_00432 2e-152 degV S DegV family
HEPMHJLG_00434 2.7e-20 K Transcriptional
HEPMHJLG_00435 2e-79 rplM J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HEPMHJLG_00436 7.3e-65 rpsI J Belongs to the universal ribosomal protein uS9 family
HEPMHJLG_00437 1.7e-89 S Protein conserved in bacteria
HEPMHJLG_00438 6.7e-89 H Methyltransferase
HEPMHJLG_00440 1.2e-101 cadD P cadmium resistance
HEPMHJLG_00441 4.5e-55 cadC K Bacterial regulatory protein, arsR family
HEPMHJLG_00442 2e-18
HEPMHJLG_00443 1.5e-29 K Helix-turn-helix domain
HEPMHJLG_00444 6e-85
HEPMHJLG_00445 8.5e-140 srtB 3.4.22.70 S sortase, SrtB family
HEPMHJLG_00446 8.2e-232 capA M Bacterial capsule synthesis protein
HEPMHJLG_00447 6.1e-39 gcvR T UPF0237 protein
HEPMHJLG_00448 2.3e-243 XK27_08635 S UPF0210 protein
HEPMHJLG_00449 7.3e-132 ais G Phosphoglycerate mutase
HEPMHJLG_00450 2.3e-142 vanY 3.4.17.14 M D-alanyl-D-alanine carboxypeptidase
HEPMHJLG_00451 2.7e-100 acmA 3.2.1.17, 3.4.17.14, 3.5.1.28 NU Muramidase (Flagellum-specific)
HEPMHJLG_00452 1.3e-185 hrcA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
HEPMHJLG_00453 5.3e-63 grpE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HEPMHJLG_00454 6e-303 dnaK O Heat shock 70 kDa protein
HEPMHJLG_00455 1.7e-103 thiJ-2 3.5.1.124 S DJ-1/PfpI family
HEPMHJLG_00456 8e-189 dnaJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
HEPMHJLG_00457 1e-139 truA 5.4.99.12 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
HEPMHJLG_00458 4e-136 thiD 2.7.1.35, 2.7.1.49, 2.7.4.7 H phosphomethylpyrimidine kinase
HEPMHJLG_00459 1.5e-80 hmpT S cog cog4720
HEPMHJLG_00467 5.6e-164 ppaC 3.6.1.1 C inorganic pyrophosphatase
HEPMHJLG_00468 7.3e-104 S Domain of unknown function (DUF1803)
HEPMHJLG_00469 7.8e-102 ygaC J Belongs to the UPF0374 family
HEPMHJLG_00470 2e-138 recX 2.4.1.337 GT4 S Regulatory protein RecX
HEPMHJLG_00471 1.5e-247 rumA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HEPMHJLG_00472 1.4e-192 asnA 6.3.1.1 E aspartate--ammonia ligase
HEPMHJLG_00473 1.7e-257 lysC 2.7.2.4 E Belongs to the aspartokinase family
HEPMHJLG_00474 1.6e-117 S HAD hydrolase, family IA, variant 3
HEPMHJLG_00475 2.1e-140 phaB 5.3.3.14, 5.3.3.18 I Belongs to the enoyl-CoA hydratase isomerase family
HEPMHJLG_00476 5.2e-72 marR K Transcriptional regulator, MarR family
HEPMHJLG_00477 1.1e-170 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEPMHJLG_00478 3.3e-30 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEPMHJLG_00479 2e-172 fabK 1.3.1.9 S 2-Nitropropane dioxygenase
HEPMHJLG_00480 3e-162 fabD 2.3.1.39 I Malonyl CoA-acyl carrier protein transacylase
HEPMHJLG_00481 1.8e-125 IQ reductase
HEPMHJLG_00482 2.6e-233 fabF 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
HEPMHJLG_00483 5.6e-54 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
HEPMHJLG_00484 1.5e-71 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
HEPMHJLG_00485 2e-255 accC 6.3.4.14, 6.4.1.2 I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
HEPMHJLG_00486 5e-159 accD 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HEPMHJLG_00487 1.5e-138 accA 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
HEPMHJLG_00488 4.7e-90 luxS 4.4.1.21 H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
HEPMHJLG_00489 7.1e-207 rny D Endoribonuclease that initiates mRNA decay
HEPMHJLG_00490 6.8e-112 fruR K transcriptional
HEPMHJLG_00491 8.4e-165 pfkB 2.7.1.11, 2.7.1.56 H Belongs to the carbohydrate kinase PfkB family. LacC subfamily
HEPMHJLG_00492 0.0 fruA 2.7.1.202 G phosphotransferase system
HEPMHJLG_00493 1.1e-256 gor 1.8.1.7 C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEPMHJLG_00494 9.5e-236 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
HEPMHJLG_00496 8e-213 iscS2 2.8.1.7 E Cysteine sulfinate desulfinase cysteine desulfurase and related enzymes
HEPMHJLG_00497 1.7e-224 thiI 2.8.1.4 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HEPMHJLG_00498 1.9e-291 gtf1 2.4.1.52 GT4 M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
HEPMHJLG_00499 2.8e-254 gtf2 M A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1
HEPMHJLG_00500 1.7e-93 2.3.1.128 K acetyltransferase
HEPMHJLG_00501 4.5e-49 rplU J This protein binds to 23S rRNA in the presence of protein L20
HEPMHJLG_00502 1.5e-46 rpmA J Belongs to the bacterial ribosomal protein bL27 family
HEPMHJLG_00503 3.8e-133 ydaF_2 J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEPMHJLG_00504 5e-63 WQ51_03320 S cog cog4835
HEPMHJLG_00505 4.2e-150 XK27_08360 S EDD domain protein, DegV family
HEPMHJLG_00506 6.3e-137 dapB 1.17.1.8 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
HEPMHJLG_00507 9.3e-220 cca 2.7.7.19, 2.7.7.72 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HEPMHJLG_00508 0.0 yfmR S abc transporter atp-binding protein
HEPMHJLG_00509 1.7e-26 U response to pH
HEPMHJLG_00510 1.8e-128 3.6.1.13, 3.6.1.55 F AdP-ribose pyrophosphatase
HEPMHJLG_00511 6.3e-215 nadD 2.7.1.22, 2.7.7.1, 2.7.7.18, 3.6.1.55 H adenylyltransferase
HEPMHJLG_00512 2.8e-257 gdhA 1.4.1.4 E Belongs to the Glu Leu Phe Val dehydrogenases family
HEPMHJLG_00513 1.1e-282 S Psort location CytoplasmicMembrane, score
HEPMHJLG_00514 4.6e-70 def_1 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins
HEPMHJLG_00515 3.3e-74 K DNA-binding transcription factor activity
HEPMHJLG_00516 0.0 lmrA1 V abc transporter atp-binding protein
HEPMHJLG_00517 0.0 lmrA2 V abc transporter atp-binding protein
HEPMHJLG_00518 3.3e-112 K Acetyltransferase (GNAT) family
HEPMHJLG_00519 8.7e-113 2.7.6.5 S Region found in RelA / SpoT proteins
HEPMHJLG_00520 1.7e-117 T response regulator
HEPMHJLG_00521 8.5e-213 sptS 2.7.13.3 T Histidine kinase
HEPMHJLG_00522 1.7e-131 pyrH 2.7.4.22 F Catalyzes the reversible phosphorylation of UMP to UDP
HEPMHJLG_00523 1.7e-91 frr J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
HEPMHJLG_00524 4.5e-160 cvfB S Protein conserved in bacteria
HEPMHJLG_00525 3.7e-34 yozE S Belongs to the UPF0346 family
HEPMHJLG_00526 6e-137 sip M LysM domain protein
HEPMHJLG_00527 2.8e-191 phoH T phosphate starvation-inducible protein PhoH
HEPMHJLG_00532 0.0 metG 6.1.1.10, 6.1.1.20 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEPMHJLG_00533 9.6e-163 S reductase
HEPMHJLG_00534 4.7e-168 K transcriptional regulator (lysR family)
HEPMHJLG_00535 2.7e-105 S CAAX amino terminal protease family protein
HEPMHJLG_00536 2.8e-303 S Glucan-binding protein C
HEPMHJLG_00537 7.3e-163 S CHAP domain
HEPMHJLG_00538 3.7e-54 insK L Integrase core domain protein
HEPMHJLG_00539 5.2e-78 L transposition
HEPMHJLG_00540 3.5e-185 coiA 3.6.4.12 S Competence protein
HEPMHJLG_00541 0.0 pepF E oligoendopeptidase F
HEPMHJLG_00542 6.7e-218 oxlT P COG0477 Permeases of the major facilitator superfamily
HEPMHJLG_00543 5.4e-127 yrrM 2.1.1.104 S O-Methyltransferase
HEPMHJLG_00544 7.8e-168 prsA 3.1.3.16, 5.2.1.8 O peptidyl-prolyl cis-trans isomerase activity
HEPMHJLG_00545 1.7e-84 yxjI S LURP-one-related
HEPMHJLG_00546 0.0 alaS 6.1.1.7 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HEPMHJLG_00547 5.2e-77 L COG1943 Transposase and inactivated derivatives
HEPMHJLG_00548 3.5e-59 K sequence-specific DNA binding
HEPMHJLG_00549 1.2e-09
HEPMHJLG_00551 0.0 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
HEPMHJLG_00552 4.3e-138 agrA KT response regulator
HEPMHJLG_00553 3.1e-07
HEPMHJLG_00554 5.6e-135 agrA KT response regulator
HEPMHJLG_00555 3e-232 2.7.13.3 T GHKL domain
HEPMHJLG_00557 2e-208 vanY 3.4.17.14, 3.5.1.28 M D-alanyl-D-alanine carboxypeptidase
HEPMHJLG_00558 0.0 vanY 3.4.17.14, 3.5.1.28 M D-alanyl-D-alanine carboxypeptidase
HEPMHJLG_00559 1.3e-142 cnhA 3.5.1.3 S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
HEPMHJLG_00560 2.4e-228 mtnE 2.6.1.83 E mutations do not affect methionine salvage in vivo however
HEPMHJLG_00561 2.7e-188 argC 1.2.1.38 E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HEPMHJLG_00562 2.8e-216 argJ 2.3.1.1, 2.3.1.35, 2.7.2.8 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HEPMHJLG_00563 5.6e-127 argB 2.7.2.8 E Belongs to the acetylglutamate kinase family. ArgB subfamily
HEPMHJLG_00564 1.2e-205 argD 2.6.1.11, 2.6.1.17 E acetylornithine aminotransferase
HEPMHJLG_00565 2.7e-128 yxkH G deacetylase
HEPMHJLG_00566 6.8e-237 hom 1.1.1.3, 2.7.2.4 E homoserine dehydrogenase
HEPMHJLG_00567 6.3e-154 thrB 2.7.1.39 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
HEPMHJLG_00568 1.1e-148 rarD S Transporter
HEPMHJLG_00569 2.6e-16 T peptidase
HEPMHJLG_00570 3e-14 coiA 3.6.4.12 S Competence protein
HEPMHJLG_00571 1e-107 S COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HEPMHJLG_00572 5.5e-106 rimL 2.3.1.128, 5.2.1.8 J COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
HEPMHJLG_00573 1.6e-174 S Helix-hairpin-helix DNA-binding motif class 1
HEPMHJLG_00574 0.0 valS 6.1.1.9 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
HEPMHJLG_00575 1e-155 S AIPR protein
HEPMHJLG_00576 3.5e-56 lrgA S Effector of murein hydrolase LrgA
HEPMHJLG_00577 1.6e-115 lrgB M Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like proteins CidA and or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses
HEPMHJLG_00578 4.2e-98 3.1.3.18 S IA, variant 1
HEPMHJLG_00579 0.0 gyrB 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HEPMHJLG_00580 6e-305 ezrA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HEPMHJLG_00581 2.2e-114 serB 3.1.3.3 E phosphoserine phosphatase
HEPMHJLG_00582 3.2e-07 N PFAM Uncharacterised protein family UPF0150
HEPMHJLG_00583 1.1e-153 EG Permeases of the drug metabolite transporter (DMT) superfamily
HEPMHJLG_00585 6.4e-63 ycaO O OsmC-like protein
HEPMHJLG_00586 1.9e-62 paaI Q protein possibly involved in aromatic compounds catabolism
HEPMHJLG_00587 5.7e-10 O ADP-ribosylglycohydrolase
HEPMHJLG_00588 1.2e-134 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
HEPMHJLG_00590 6.7e-248 obg S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HEPMHJLG_00591 1.7e-17 XK27_00735
HEPMHJLG_00592 1e-136 glnQ 3.6.3.21 E abc transporter atp-binding protein
HEPMHJLG_00593 0.0 glnP P ABC-type amino acid transport signal transduction systems periplasmic component domain
HEPMHJLG_00594 4.9e-168 S CAAX amino terminal protease family protein
HEPMHJLG_00596 0.0 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
HEPMHJLG_00597 1.3e-84 mutT 3.6.1.55 F Nudix family
HEPMHJLG_00598 6.4e-140 ET ABC transporter
HEPMHJLG_00599 5.9e-138 ET Belongs to the bacterial solute-binding protein 3 family
HEPMHJLG_00600 1.1e-211 arcT 2.6.1.1 E Aminotransferase
HEPMHJLG_00601 1.9e-136 gltS ET Belongs to the bacterial solute-binding protein 3 family
HEPMHJLG_00602 3.2e-20 rpsU J Belongs to the bacterial ribosomal protein bS21 family
HEPMHJLG_00603 8.9e-44 mscL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
HEPMHJLG_00604 0.0 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
HEPMHJLG_00605 2.3e-201 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
HEPMHJLG_00606 3.4e-55 yitW K metal-sulfur cluster biosynthetic enzyme
HEPMHJLG_00607 2.5e-172 yfdH GT2 M COG0463, glycosyltransferases involved in cell wall biogenesis
HEPMHJLG_00608 1.1e-158 rfbD 1.1.1.133, 5.1.3.13 M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
HEPMHJLG_00609 6.1e-213 rgpA GT4 M Domain of unknown function (DUF1972)
HEPMHJLG_00610 1e-173 rgpB GT2 M Glycosyltransferase, group 2 family protein
HEPMHJLG_00611 5.2e-142 rgpC GM Transport permease protein
HEPMHJLG_00612 5.3e-223 rgpD 3.6.3.38 P Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system
HEPMHJLG_00613 9.2e-184 rgpEc GT2 M Glycosyl transferase family 2
HEPMHJLG_00614 0.0 rgpF M Rhamnan synthesis protein F
HEPMHJLG_00615 4.3e-156 rfbJ M Glycosyl transferase family 2
HEPMHJLG_00616 4.3e-46 M Psort location CytoplasmicMembrane, score
HEPMHJLG_00617 7.5e-166
HEPMHJLG_00618 1.2e-118 radC E Belongs to the UPF0758 family
HEPMHJLG_00619 5.3e-127 puuD T peptidase C26
HEPMHJLG_00620 1.9e-118 rex K Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HEPMHJLG_00621 1.8e-59 XK27_04120 S Putative amino acid metabolism
HEPMHJLG_00622 1.1e-203 iscS 2.8.1.7 E Cysteine desulfurase
HEPMHJLG_00623 5.1e-176 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HEPMHJLG_00624 7.1e-101 yjbK S Adenylate cyclase
HEPMHJLG_00625 3e-119 yjbM 2.7.6.5 S Gtp pyrophosphokinase
HEPMHJLG_00626 7.5e-152 nadK 2.7.1.23 H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HEPMHJLG_00627 3.1e-172 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 J Responsible for synthesis of pseudouridine from uracil
HEPMHJLG_00628 6.3e-174 pta 2.3.1.8, 3.6.3.21 C phosphate acetyltransferase
HEPMHJLG_00629 0.0 amiA E ABC transporter, substrate-binding protein, family 5
HEPMHJLG_00630 2.7e-311 amiA E ABC transporter, substrate-binding protein, family 5
HEPMHJLG_00631 4.3e-275 amiC P ABC transporter (Permease
HEPMHJLG_00632 3.5e-166 amiD P ABC transporter (Permease
HEPMHJLG_00633 1.3e-201 oppD P Belongs to the ABC transporter superfamily
HEPMHJLG_00634 3.1e-170 oppF P Belongs to the ABC transporter superfamily
HEPMHJLG_00635 1.7e-129 V Psort location CytoplasmicMembrane, score
HEPMHJLG_00636 2.3e-117 skfE V abc transporter atp-binding protein
HEPMHJLG_00637 6.1e-61 yvoA_1 K Transcriptional
HEPMHJLG_00638 6.1e-143 supH S overlaps another CDS with the same product name
HEPMHJLG_00639 1.8e-142 XK27_02985 S overlaps another CDS with the same product name
HEPMHJLG_00640 1.8e-195 ftsY U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HEPMHJLG_00641 8.8e-113 gmk 2.7.4.8 F Essential for recycling GMP and indirectly, cGMP
HEPMHJLG_00642 3.6e-46 rpoZ 2.7.7.6 K DNA-directed 5'-3' RNA polymerase activity
HEPMHJLG_00643 0.0 priA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HEPMHJLG_00644 2.8e-171 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HEPMHJLG_00645 3.2e-245 sun 2.1.1.176 J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HEPMHJLG_00646 4.8e-137 stp 3.1.3.16 T phosphatase
HEPMHJLG_00647 1.4e-302 prkC 2.7.11.1 KLT serine threonine protein kinase
HEPMHJLG_00648 3.8e-94 kcsA P Ion transport protein
HEPMHJLG_00649 8.6e-117 yvqF S Membrane
HEPMHJLG_00650 1.9e-170 vraS 2.7.13.3 T Histidine kinase
HEPMHJLG_00651 1.4e-113 vraR K Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HEPMHJLG_00654 7.6e-94 rimM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HEPMHJLG_00655 1.9e-135 trmD 2.1.1.228, 4.6.1.12 J Belongs to the RNA methyltransferase TrmD family
HEPMHJLG_00656 1.2e-188 trxB1 1.18.1.2, 1.19.1.1 C Ferredoxin--NADP reductase
HEPMHJLG_00657 0.0 ftsK D Belongs to the FtsK SpoIIIE SftA family
HEPMHJLG_00658 0.0 pulA 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
HEPMHJLG_00659 0.0 glgB 2.4.1.18, 3.2.1.141, 3.2.1.20 CBM48,GH13,GH31 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HEPMHJLG_00660 2e-187 glgC 2.7.7.27 H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HEPMHJLG_00661 5.2e-180 glgD 2.4.1.21, 2.7.7.27 GT5 G glucose-1-phosphate adenylyltransferase
HEPMHJLG_00662 2.2e-284 glgA 2.4.1.21 GT5 G Synthesizes alpha-1,4-glucan chains using ADP-glucose
HEPMHJLG_00663 0.0 glgP 2.4.1.1 GT35 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
HEPMHJLG_00664 6.5e-99 2.3.1.128 K Acetyltransferase GNAT Family
HEPMHJLG_00665 5.7e-291 S Protein of unknown function (DUF3114)
HEPMHJLG_00667 0.0 gshF 6.3.2.2, 6.3.2.29, 6.3.2.30, 6.3.2.4 H Belongs to the glutamate--cysteine ligase type 1 family
HEPMHJLG_00668 3.6e-297 V abc transporter atp-binding protein
HEPMHJLG_00669 0.0 V abc transporter atp-binding protein
HEPMHJLG_00670 3.7e-189 XK27_10075 S abc transporter atp-binding protein
HEPMHJLG_00671 0.0 glgE 2.3.1.12, 2.4.99.16, 3.2.1.1, 3.2.1.14 GH13,GH18 M Pilin isopeptide linkage domain protein
HEPMHJLG_00672 0.0 M Pilin isopeptide linkage domain protein
HEPMHJLG_00673 0.0 zmpB M signal peptide protein, YSIRK family
HEPMHJLG_00674 0.0 GM domain, Protein
HEPMHJLG_00675 9e-223 sbcD L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
HEPMHJLG_00676 0.0 sbcC L ATPase involved in DNA repair
HEPMHJLG_00677 6.9e-09
HEPMHJLG_00679 3.4e-155 cat 2.3.1.28 S acetyltransferase'
HEPMHJLG_00680 0.0 M family 8
HEPMHJLG_00681 1e-146 epsH S acetyltransferase'
HEPMHJLG_00682 9.9e-238 M Glycosyltransferase, family 8
HEPMHJLG_00683 7.1e-286 tagE 2.4.1.52 GT4 M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
HEPMHJLG_00684 5.8e-193 M A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1
HEPMHJLG_00685 3.3e-186 nss M transferase activity, transferring glycosyl groups
HEPMHJLG_00686 1.9e-236 M Glycosyltransferase, family 8
HEPMHJLG_00687 2.5e-166 cpsJ M Glycosyltransferase group 2 family protein
HEPMHJLG_00688 0.0 M cog cog1442
HEPMHJLG_00689 5.8e-241 M family 8
HEPMHJLG_00690 2.3e-165 secY2 U Part of the accessory SecA2 SecY2 system specifically required for export of
HEPMHJLG_00691 9.5e-310 asp1 S Accessory Sec system protein Asp1
HEPMHJLG_00692 9.4e-302 asp2 3.4.11.5 S Accessory Sec system protein Asp2
HEPMHJLG_00693 1.6e-68 asp3 S Accessory Sec system protein Asp3
HEPMHJLG_00694 0.0 secA2 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
HEPMHJLG_00695 3.9e-13 S Accessory secretory protein Sec Asp4
HEPMHJLG_00696 7e-12 S Accessory secretory protein Sec, Asp5
HEPMHJLG_00697 1.9e-116 gltJ P ABC transporter (Permease
HEPMHJLG_00698 2.9e-111 tcyB_2 P ABC transporter (permease)
HEPMHJLG_00699 6.5e-154 endA F DNA RNA non-specific endonuclease
HEPMHJLG_00700 5.5e-26 epuA S DNA-directed RNA polymerase subunit beta
HEPMHJLG_00701 2e-233 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HEPMHJLG_00703 2e-208 G Belongs to the glycosyl hydrolase 8 (cellulase D) family
HEPMHJLG_00704 5.5e-250 ydaM M Glycosyltransferases, probably involved in cell wall biogenesis
HEPMHJLG_00706 8.4e-137
HEPMHJLG_00707 6.6e-215 mnaA 5.1.3.14 G Belongs to the UDP-N-acetylglucosamine 2-epimerase family
HEPMHJLG_00708 8.9e-76 L Transposase (IS116 IS110 IS902 family)
HEPMHJLG_00709 1.3e-276 thrC 4.2.3.1 E Threonine synthase
HEPMHJLG_00710 7.1e-226 norN V Mate efflux family protein
HEPMHJLG_00711 1.4e-57 asp S cog cog1302
HEPMHJLG_00712 3.8e-304 yloV S kinase related to dihydroxyacetone kinase
HEPMHJLG_00713 0.0 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
HEPMHJLG_00714 0.0 ilvB 2.2.1.6 EH Acetolactate synthase
HEPMHJLG_00715 2.2e-76 ilvN 2.2.1.6 E Acetolactate synthase
HEPMHJLG_00716 3e-195 ilvC 1.1.1.86 H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HEPMHJLG_00717 3.4e-14 rpmH J Ribosomal protein L34
HEPMHJLG_00718 6.9e-101 1.6.5.2 S NADPH-quinone reductase (modulator of drug activity B)
HEPMHJLG_00719 2.9e-105 K Transcriptional regulator
HEPMHJLG_00720 1.2e-151 jag S RNA-binding protein
HEPMHJLG_00721 9.7e-147 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HEPMHJLG_00722 3.8e-54 rnpA 3.1.26.5 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
HEPMHJLG_00723 1.6e-263 argH 4.3.2.1 E Argininosuccinate lyase
HEPMHJLG_00724 5.8e-230 argG 6.3.4.5 E Belongs to the argininosuccinate synthase family. Type 1 subfamily
HEPMHJLG_00726 1.9e-07
HEPMHJLG_00731 0.0 polC 2.7.7.7 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HEPMHJLG_00732 1.6e-235 pepS E COG2309 Leucyl aminopeptidase (aminopeptidase T)
HEPMHJLG_00733 1.2e-35 XK27_02060 S Transglycosylase associated protein
HEPMHJLG_00734 2e-71 badR K Transcriptional regulator, marr family
HEPMHJLG_00735 1.1e-95 S reductase
HEPMHJLG_00737 5e-33 3.4.24.40 U Large extracellular alpha-helical protein
HEPMHJLG_00739 2.4e-115 nrdG 1.97.1.4 O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HEPMHJLG_00740 4.6e-88 XK27_10930 K acetyltransferase
HEPMHJLG_00741 7.5e-14
HEPMHJLG_00742 0.0 nrdD 1.1.98.6 F Ribonucleoside-triphosphate reductase
HEPMHJLG_00743 5.8e-289 ccs S the current gene model (or a revised gene model) may contain a frame shift
HEPMHJLG_00744 1.1e-89 usp 3.5.1.28 CBM50 S CHAP domain
HEPMHJLG_00745 4.2e-84 mreD M rod shape-determining protein MreD
HEPMHJLG_00746 9.2e-110 mreC M Involved in formation and maintenance of cell shape
HEPMHJLG_00751 3e-93 gltJ P ABC transporter (Permease
HEPMHJLG_00752 2.9e-111 tcyB_2 P ABC transporter (permease)
HEPMHJLG_00753 6.7e-139 glnQ 3.6.3.21 E abc transporter atp-binding protein
HEPMHJLG_00756 8.6e-82 L Transposase
HEPMHJLG_00757 4.4e-62 rplQ J ribosomal protein l17
HEPMHJLG_00758 1.1e-170 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HEPMHJLG_00759 1.9e-62 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HEPMHJLG_00760 4e-57 rpsM J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HEPMHJLG_00761 6e-15 rpmJ J Belongs to the bacterial ribosomal protein bL36 family
HEPMHJLG_00762 2.7e-32 infA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HEPMHJLG_00763 6.2e-114 adk 2.7.4.3 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
HEPMHJLG_00764 3e-232 secY U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
HEPMHJLG_00765 5.7e-58 rplO J binds to the 23S rRNA
HEPMHJLG_00766 1.9e-23 rpmD J ribosomal protein l30
HEPMHJLG_00767 1.3e-79 rpsE J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HEPMHJLG_00768 1.9e-56 rplR J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HEPMHJLG_00769 6.6e-93 rplF J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HEPMHJLG_00770 1.2e-67 rpsH J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HEPMHJLG_00771 1.5e-28 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HEPMHJLG_00772 1.6e-94 rplE J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HEPMHJLG_00773 1.4e-47 rplX J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HEPMHJLG_00774 3.9e-60 rplN J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HEPMHJLG_00775 1.7e-38 rpsQ J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HEPMHJLG_00776 3.5e-26 rpmC J Belongs to the universal ribosomal protein uL29 family
HEPMHJLG_00777 1.1e-71 rplP J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HEPMHJLG_00778 1.6e-117 rpsC J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HEPMHJLG_00779 7.3e-53 rplV J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HEPMHJLG_00780 8.3e-47 rpsS J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HEPMHJLG_00781 6.8e-153 rplB J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HEPMHJLG_00782 2.4e-44 rplW J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
HEPMHJLG_00783 5.7e-104 rplD J Forms part of the polypeptide exit tunnel
HEPMHJLG_00784 2.4e-110 rplC J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HEPMHJLG_00785 2.9e-48 rpsJ J Involved in the binding of tRNA to the ribosomes
HEPMHJLG_00786 3e-187 ruvB 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
HEPMHJLG_00787 0.0 XK27_09800 I Acyltransferase
HEPMHJLG_00788 4.8e-35 XK27_09805 S MORN repeat protein
HEPMHJLG_00789 3.4e-79 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HEPMHJLG_00790 2.7e-249 purA 6.3.4.4 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HEPMHJLG_00791 4.8e-93 adk 2.7.4.3 F topology modulation protein
HEPMHJLG_00792 4.9e-174 yeiH S membrane
HEPMHJLG_00793 5.5e-89 K sequence-specific DNA binding
HEPMHJLG_00794 2.6e-140 L Replication initiation factor
HEPMHJLG_00795 1.9e-18 S Domain of unknown function (DUF3173)
HEPMHJLG_00796 1.3e-215 int L Belongs to the 'phage' integrase family
HEPMHJLG_00798 7e-234 rarA L ATPase related to the helicase subunit of the Holliday junction resolvase
HEPMHJLG_00799 8.4e-27 rpmB J Belongs to the bacterial ribosomal protein bL28 family
HEPMHJLG_00800 6.3e-44 yrzL S Belongs to the UPF0297 family
HEPMHJLG_00801 2.3e-69 yqgF L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HEPMHJLG_00802 3.2e-44 yrzB S Belongs to the UPF0473 family
HEPMHJLG_00803 1.2e-146 L Transposase
HEPMHJLG_00804 2.8e-79 L Transposase
HEPMHJLG_00805 1.3e-153 supH 3.1.3.102, 3.1.3.104 S Sucrose-6F-phosphate phosphohydrolase
HEPMHJLG_00806 2.5e-109 pgm G Belongs to the phosphoglycerate mutase family
HEPMHJLG_00807 7e-107 G Belongs to the phosphoglycerate mutase family
HEPMHJLG_00808 1.5e-109 G Belongs to the phosphoglycerate mutase family
HEPMHJLG_00809 2.9e-199 S hmm pf01594
HEPMHJLG_00810 1.2e-287 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
HEPMHJLG_00811 4.9e-39 S granule-associated protein
HEPMHJLG_00812 4.8e-285 S unusual protein kinase
HEPMHJLG_00813 3.7e-103 estA E Lysophospholipase L1 and related esterases
HEPMHJLG_00814 2.7e-157 rssA S Phospholipase, patatin family
HEPMHJLG_00815 4.4e-181 dacA1 3.4.16.4 M Belongs to the peptidase S11 family
HEPMHJLG_00816 2.3e-246 dacA1 3.4.16.4 M Belongs to the peptidase S11 family
HEPMHJLG_00817 4.3e-217 yeaB K Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HEPMHJLG_00818 1.7e-119 ung 3.2.2.27 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HEPMHJLG_00819 4.8e-235 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
HEPMHJLG_00820 0.0 S the current gene model (or a revised gene model) may contain a frame shift
HEPMHJLG_00821 2.4e-234 2.7.13.3 T protein histidine kinase activity
HEPMHJLG_00822 1.1e-215 hpk9 2.7.13.3 T protein histidine kinase activity
HEPMHJLG_00823 6.6e-184 acoA 1.2.4.1, 1.2.4.4 C Dehydrogenase E1 component
HEPMHJLG_00824 1.4e-181 acoB 1.2.4.1, 1.2.4.4 C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
HEPMHJLG_00825 8.1e-212 acoC 2.3.1.12 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
HEPMHJLG_00826 0.0 lpdA 1.8.1.4 C Dehydrogenase
HEPMHJLG_00827 0.0 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
HEPMHJLG_00828 0.0 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
HEPMHJLG_00829 4.9e-146 ycdO P periplasmic lipoprotein involved in iron transport
HEPMHJLG_00830 7.6e-230 ycdB P peroxidase
HEPMHJLG_00831 5.7e-292 ywbL P COG0672 High-affinity Fe2 Pb2 permease
HEPMHJLG_00832 1.3e-123 tatC U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HEPMHJLG_00833 6.1e-25 tatA U protein secretion
HEPMHJLG_00834 1.8e-212 msmX P Belongs to the ABC transporter superfamily
HEPMHJLG_00835 9.8e-152 malG P ABC transporter (Permease
HEPMHJLG_00836 9.7e-250 malF P ABC transporter (Permease
HEPMHJLG_00837 9.6e-228 malX G ABC transporter
HEPMHJLG_00838 8.7e-171 malR K Transcriptional regulator
HEPMHJLG_00839 1.2e-301 malQ 2.4.1.25 GH77 G 4-alpha-glucanotransferase
HEPMHJLG_00840 0.0 glgP 2.4.1.1 GT35 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
HEPMHJLG_00841 3.2e-12
HEPMHJLG_00842 1.9e-186 lplA 6.3.1.20 H Lipoate-protein ligase
HEPMHJLG_00843 6e-194 xerS D Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division
HEPMHJLG_00844 0.0 pepN 3.4.11.2 E aminopeptidase
HEPMHJLG_00845 3.2e-113 phoU P Plays a role in the regulation of phosphate uptake
HEPMHJLG_00846 3.9e-139 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
HEPMHJLG_00847 4e-150 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
HEPMHJLG_00848 1.5e-155 pstA P phosphate transport system permease
HEPMHJLG_00849 1.9e-156 pstC P probably responsible for the translocation of the substrate across the membrane
HEPMHJLG_00850 9e-156 pstS P phosphate
HEPMHJLG_00851 6.9e-253 rsmF 2.1.1.176, 2.1.1.178 J NOL1 NOP2 sun family protein
HEPMHJLG_00852 2e-143 suhB 3.1.3.25 G Belongs to the inositol monophosphatase superfamily
HEPMHJLG_00853 1e-44 yktA S Belongs to the UPF0223 family
HEPMHJLG_00854 1.6e-70 spxA 1.20.4.1 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
HEPMHJLG_00855 1.3e-170 ribF 2.7.1.26, 2.7.7.2 H Belongs to the ribF family
HEPMHJLG_00856 3.2e-150 truB 5.4.99.25 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HEPMHJLG_00857 6.9e-248 XK27_04775 S hemerythrin HHE cation binding domain
HEPMHJLG_00858 4.7e-35 M1-755 S Domain of unknown function (DUF1858)
HEPMHJLG_00859 1.3e-111 hsdS2 2.1.1.72 V Type I restriction modification DNA specificity domain
HEPMHJLG_00860 8.5e-87 tpx 1.11.1.15 O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HEPMHJLG_00861 8.7e-60 S haloacid dehalogenase-like hydrolase
HEPMHJLG_00862 2.9e-27 S haloacid dehalogenase-like hydrolase
HEPMHJLG_00863 4.3e-239 metY 2.5.1.49 E o-acetylhomoserine
HEPMHJLG_00864 0.0 pcrA 3.6.4.12 L ATP-dependent DNA helicase
HEPMHJLG_00865 4.3e-242 agcS E (Alanine) symporter
HEPMHJLG_00866 5.6e-245 mnmE S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HEPMHJLG_00867 2.7e-177 bglC K Transcriptional regulator
HEPMHJLG_00868 0.0 sasH 3.1.3.5, 3.6.1.45 F Belongs to the 5'-nucleotidase family
HEPMHJLG_00869 6.4e-82 yecS P ABC transporter (Permease
HEPMHJLG_00870 1.3e-148 yckB ET Belongs to the bacterial solute-binding protein 3 family
HEPMHJLG_00871 1.1e-240 nylA 3.5.1.4 J Belongs to the amidase family
HEPMHJLG_00872 4.4e-112 pyrE 2.4.2.10, 4.1.1.23 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HEPMHJLG_00873 4.5e-126 pyrF 4.1.1.23 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
HEPMHJLG_00874 6.5e-176 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
HEPMHJLG_00875 5e-145 pyrK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )
HEPMHJLG_00876 2.6e-92 thiJ 2.7.11.1, 3.5.1.124 S DJ-1 family
HEPMHJLG_00877 1.3e-132 S TraX protein
HEPMHJLG_00878 3.3e-308 FbpA K RNA-binding protein homologous to eukaryotic snRNP
HEPMHJLG_00879 2.4e-260 S Psort location CytoplasmicMembrane, score
HEPMHJLG_00880 1.4e-232 dinF V Mate efflux family protein
HEPMHJLG_00881 1.9e-170 P abc-type fe3 -hydroxamate transport system, periplasmic component
HEPMHJLG_00882 1.5e-21 V Type III restriction enzyme, res subunit
HEPMHJLG_00883 1.2e-106 V Type III restriction enzyme, res subunit
HEPMHJLG_00884 6.6e-19 V Type III restriction enzyme, res subunit
HEPMHJLG_00885 5.4e-110 gph 3.1.3.18 S HAD hydrolase, family IA, variant 1
HEPMHJLG_00886 2e-236 S the current gene model (or a revised gene model) may contain a frame shift
HEPMHJLG_00887 3.4e-186 adhB 1.1.1.1, 1.1.1.14 E Dehydrogenase
HEPMHJLG_00888 6.1e-194 hemH 4.99.1.1, 4.99.1.9 H Catalyzes the ferrous insertion into protoporphyrin IX
HEPMHJLG_00889 7.3e-161 czcD P cation diffusion facilitator family transporter
HEPMHJLG_00890 1.4e-104 K Transcriptional regulator, TetR family
HEPMHJLG_00891 5.9e-61 S Protein of unknown function with HXXEE motif
HEPMHJLG_00892 1.8e-11
HEPMHJLG_00893 2e-74 pnuC H nicotinamide mononucleotide transporter
HEPMHJLG_00894 3e-113 tnp L DDE domain
HEPMHJLG_00895 9.7e-149 cbiO2 P 'abc transporter, ATP-binding protein
HEPMHJLG_00896 5.9e-157 P abc transporter atp-binding protein
HEPMHJLG_00897 1.3e-132 cbiQ P Cobalt transport protein
HEPMHJLG_00898 2.2e-92 2.7.7.65 T Psort location CytoplasmicMembrane, score
HEPMHJLG_00899 4.4e-141 S Phenazine biosynthesis protein
HEPMHJLG_00900 6.5e-108 magIII L Base excision DNA repair protein, HhH-GPD family
HEPMHJLG_00901 1e-263 proWX P ABC transporter
HEPMHJLG_00902 4.6e-129 proV E abc transporter atp-binding protein
HEPMHJLG_00903 4.5e-169 C alcohol dehydrogenase
HEPMHJLG_00904 4.6e-133 1.6.5.2 GM NmrA-like family
HEPMHJLG_00905 2.3e-67 mgrA K Transcriptional regulator, MarR family
HEPMHJLG_00906 4e-36 S Macro domain
HEPMHJLG_00907 9.4e-12 S Macro domain
HEPMHJLG_00908 2.6e-96 K COG COG0846 NAD-dependent protein deacetylases, SIR2 family
HEPMHJLG_00909 2.8e-41 C Pyridoxamine 5'-phosphate oxidase
HEPMHJLG_00910 3.1e-130 budA 4.1.1.5 H Belongs to the alpha-acetolactate decarboxylase family
HEPMHJLG_00911 0.0 alsS 2.2.1.6 EH Belongs to the TPP enzyme family
HEPMHJLG_00914 0.0 lepA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
HEPMHJLG_00916 1e-20 L the current gene model (or a revised gene model) may contain a frame shift
HEPMHJLG_00917 4e-130 deoD 2.4.2.1, 2.4.2.28 F purine nucleoside phosphorylase
HEPMHJLG_00918 5.8e-137 yfeJ 6.3.5.2 F glutamine amidotransferase
HEPMHJLG_00919 4.7e-182 clcA_2 P Chloride transporter, ClC family
HEPMHJLG_00920 2.9e-148 punA 2.4.2.1 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HEPMHJLG_00921 5.5e-95 S Protein of unknown function (DUF1697)
HEPMHJLG_00922 1.3e-234 deoB 5.4.2.7 G Phosphotransfer between the C1 and C5 carbon atoms of pentose
HEPMHJLG_00923 1.5e-121 rpiA 2.7.1.12, 2.7.1.15, 5.3.1.6 G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HEPMHJLG_00924 8e-252 V Glucan-binding protein C
HEPMHJLG_00925 8.6e-57 ndk 2.7.4.6 F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
HEPMHJLG_00926 2e-111 XK27_05470 E Methionine synthase
HEPMHJLG_00927 5.9e-85 XK27_05470 E Methionine synthase
HEPMHJLG_00928 1.1e-258 trmFO 2.1.1.74 J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HEPMHJLG_00929 4.7e-236 T PhoQ Sensor
HEPMHJLG_00930 1.5e-118 T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HEPMHJLG_00931 2e-149 S TraX protein
HEPMHJLG_00933 1.3e-51 V ABC-2 family transporter protein
HEPMHJLG_00934 4.6e-83 mutF V AAA domain, putative AbiEii toxin, Type IV TA system
HEPMHJLG_00935 0.0 topA 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HEPMHJLG_00936 2.5e-155 dprA LU DNA protecting protein DprA
HEPMHJLG_00937 4.4e-161 GK ROK family
HEPMHJLG_00938 7.7e-135 rnhB 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HEPMHJLG_00939 2.1e-157 ylqF S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HEPMHJLG_00940 4e-127 K DNA-binding helix-turn-helix protein
HEPMHJLG_00941 2.7e-91 niaR S small molecule binding protein (contains 3H domain)
HEPMHJLG_00942 2.7e-86
HEPMHJLG_00943 1.9e-273 ffh 3.6.5.4 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HEPMHJLG_00944 2e-55 ylxM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HEPMHJLG_00945 1e-125 gntR1 K transcriptional
HEPMHJLG_00946 2.3e-303 guaA 2.3.1.128, 6.3.5.2 F Catalyzes the synthesis of GMP from XMP
HEPMHJLG_00947 2.2e-102 rimL J COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
HEPMHJLG_00948 3e-187 adhP 1.1.1.1 C alcohol dehydrogenase
HEPMHJLG_00949 1.8e-44
HEPMHJLG_00950 1.4e-49
HEPMHJLG_00951 1.5e-269 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HEPMHJLG_00952 7.9e-157 aatB ET ABC transporter substrate-binding protein
HEPMHJLG_00953 8.8e-113 glnQ 3.6.3.21 E abc transporter atp-binding protein
HEPMHJLG_00954 1.4e-105 artQ P ABC transporter (Permease
HEPMHJLG_00955 6.6e-59 phnA P Alkylphosphonate utilization operon protein PhnA
HEPMHJLG_00956 0.0 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
HEPMHJLG_00957 2.9e-165 cpsY K Transcriptional regulator
HEPMHJLG_00958 1.3e-128 mur1 3.4.17.14, 3.5.1.28 NU muramidase
HEPMHJLG_00959 7.4e-170 yeiH S Membrane
HEPMHJLG_00961 2.6e-09
HEPMHJLG_00962 5.6e-294 adcA P Belongs to the bacterial solute-binding protein 9 family
HEPMHJLG_00963 4.6e-146 XK27_10720 D peptidase activity
HEPMHJLG_00964 4e-275 pepD E Dipeptidase
HEPMHJLG_00965 2.2e-160 whiA K May be required for sporulation
HEPMHJLG_00966 1.4e-181 ybhK S Required for morphogenesis under gluconeogenic growth conditions
HEPMHJLG_00967 1.6e-163 rapZ S Displays ATPase and GTPase activities
HEPMHJLG_00968 1.4e-136 yejC S cyclic nucleotide-binding protein
HEPMHJLG_00969 6.6e-202 D nuclear chromosome segregation
HEPMHJLG_00970 1.4e-94 queF 1.7.1.13 S Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily
HEPMHJLG_00971 4.6e-134 queE 1.97.1.4, 4.3.99.3 H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
HEPMHJLG_00972 8.2e-81 queD 4.1.2.50, 4.2.3.12 H synthase
HEPMHJLG_00973 2.6e-123 queC 6.3.4.20 F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HEPMHJLG_00974 2.3e-63 tdcF 3.5.99.10 J endoribonuclease L-PSP
HEPMHJLG_00975 8.1e-200 pmrB EGP Major facilitator Superfamily
HEPMHJLG_00976 1.8e-18
HEPMHJLG_00977 9.3e-261 asnS 6.1.1.22 J Catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
HEPMHJLG_00978 2.8e-213 aspB 2.6.1.1, 2.6.1.14 E Aminotransferase
HEPMHJLG_00979 8.6e-76 ypmB S Protein conserved in bacteria
HEPMHJLG_00980 0.0 dinG 2.7.7.7, 3.6.4.12 L helicase involved in DNA repair and perhaps also replication
HEPMHJLG_00981 6.8e-113 ycbL 3.1.2.6 S COG0491 Zn-dependent hydrolases, including glyoxylases
HEPMHJLG_00982 5e-168 yufQ S Belongs to the binding-protein-dependent transport system permease family
HEPMHJLG_00983 5.1e-177 yufP S Belongs to the binding-protein-dependent transport system permease family
HEPMHJLG_00984 6.4e-282 xylG 3.6.3.17 S ABC transporter, ATP-binding protein
HEPMHJLG_00985 2.8e-191 tcsA S membrane
HEPMHJLG_00986 1.3e-64 cdd 2.4.2.2, 3.5.4.5 F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
HEPMHJLG_00987 3.5e-112 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HEPMHJLG_00988 1.9e-231 pdp 2.4.2.2, 2.4.2.4 F Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate
HEPMHJLG_00989 1.1e-104 rsmC 2.1.1.172 J Methyltransferase small domain protein
HEPMHJLG_00990 2.8e-171 coaA 2.7.1.33 F Pantothenic acid kinase
HEPMHJLG_00991 1e-29 rpsT J Binds directly to 16S ribosomal RNA
HEPMHJLG_00992 1.3e-241 T PhoQ Sensor
HEPMHJLG_00993 9.4e-121 T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HEPMHJLG_00994 0.0 fhs 6.3.4.3 F Belongs to the formate--tetrahydrofolate ligase family
HEPMHJLG_00995 1.9e-116 coaB 4.1.1.36, 6.3.2.5 H Phosphopantothenate-cysteine ligase
HEPMHJLG_00996 2.2e-91 coaBC 4.1.1.36, 6.3.2.5 H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HEPMHJLG_00997 4.1e-93 panT S ECF transporter, substrate-specific component
HEPMHJLG_00998 0.0 pgm 5.4.2.2, 5.4.2.8 G Phosphoglucomutase
HEPMHJLG_00999 1.6e-165 metF 1.5.1.20 E reductase
HEPMHJLG_01000 0.0 metE 2.1.1.14 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HEPMHJLG_01002 0.0 pabB 2.6.1.85, 4.1.3.27, 4.1.3.38 EH component I
HEPMHJLG_01003 0.0 3.6.3.8 P cation transport ATPase
HEPMHJLG_01004 2.2e-243 dltD M Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HEPMHJLG_01005 2.2e-35 dltC 6.1.1.13 IQ Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HEPMHJLG_01006 1.7e-237 dltB M Membrane protein involved in D-alanine export
HEPMHJLG_01007 1.3e-298 dltA 6.1.1.13 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HEPMHJLG_01008 0.0 XK27_10035 V abc transporter atp-binding protein
HEPMHJLG_01009 2.2e-294 yfiB1 V abc transporter atp-binding protein
HEPMHJLG_01010 1.4e-99 pvaA M lytic transglycosylase activity
HEPMHJLG_01011 2.1e-177 ndpA S 37-kD nucleoid-associated bacterial protein
HEPMHJLG_01012 2.7e-230 glyA 2.1.2.1 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HEPMHJLG_01013 4.5e-106 ywlC 2.7.7.87, 3.1.3.48 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
HEPMHJLG_01014 8.3e-143 prmB 2.1.1.297, 2.1.1.298 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
HEPMHJLG_01015 3.6e-191 prfA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HEPMHJLG_01016 5.1e-110 tdk 2.7.1.21 F thymidine kinase
HEPMHJLG_01017 5.8e-183 add 3.5.4.4 F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HEPMHJLG_01018 4.9e-153 gst O Glutathione S-transferase
HEPMHJLG_01019 1.7e-176 nrnA 3.1.13.3, 3.1.3.7 S domain protein
HEPMHJLG_01020 4.6e-174 apbE 2.7.1.180 H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
HEPMHJLG_01021 4.4e-45 rpmE2 J 50S ribosomal protein L31
HEPMHJLG_01022 3.9e-229 mntH P Mn2 and Fe2 transporters of the NRAMP family
HEPMHJLG_01023 5.8e-164 ypuA S secreted protein
HEPMHJLG_01024 2.4e-71 yaeR E COG0346 Lactoylglutathione lyase and related lyases
HEPMHJLG_01025 9.3e-133 srtA 3.4.22.70 M Sortase (surface protein transpeptidase)
HEPMHJLG_01026 0.0 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HEPMHJLG_01027 4.1e-181 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
HEPMHJLG_01028 1.4e-256 noxE P NADH oxidase
HEPMHJLG_01029 1.1e-294 yfmM S abc transporter atp-binding protein
HEPMHJLG_01030 6.1e-83 XK27_01265 S ECF-type riboflavin transporter, S component
HEPMHJLG_01031 1e-143 pdxK 2.7.1.35 H Belongs to the pyridoxine kinase family
HEPMHJLG_01032 9.4e-81 S ECF-type riboflavin transporter, S component
HEPMHJLG_01034 1e-237 XK27_08130 K Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
HEPMHJLG_01035 2.8e-226 tgt 2.4.2.29 F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
HEPMHJLG_01036 5e-72 S Psort location Cytoplasmic, score 8.96
HEPMHJLG_01037 9e-139 ykuT M mechanosensitive ion channel
HEPMHJLG_01038 5.2e-229 tig D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
HEPMHJLG_01039 1e-70 rpoE K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
HEPMHJLG_01040 5.8e-310 pyrG 6.3.4.2 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
HEPMHJLG_01041 3.8e-84 XK27_03960 S Protein of unknown function (DUF3013)
HEPMHJLG_01042 1.1e-77 mutT3 3.6.1.13, 3.6.1.55 L NUDIX domain
HEPMHJLG_01043 2.5e-83 XK27_02675 K Acetyltransferase GNAT Family
HEPMHJLG_01044 2.6e-177 prmA J Ribosomal protein L11 methyltransferase
HEPMHJLG_01045 3.4e-132 rsmE 2.1.1.193 J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
HEPMHJLG_01046 0.0 cpdB 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
HEPMHJLG_01047 9.1e-83 nrdI F Belongs to the NrdI family
HEPMHJLG_01048 0.0 relA 2.7.6.5 KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEPMHJLG_01049 2.8e-73 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
HEPMHJLG_01050 0.0 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
HEPMHJLG_01051 8.7e-237 ilvA 4.3.1.19 E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HEPMHJLG_01052 3.3e-112 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
HEPMHJLG_01053 1.3e-111 fnr5 K Catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
HEPMHJLG_01054 2.9e-194 yhjX P Major Facilitator
HEPMHJLG_01055 9.2e-43 rpsO J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HEPMHJLG_01056 5.4e-72 V VanZ like family
HEPMHJLG_01057 1.8e-180 D nuclear chromosome segregation
HEPMHJLG_01059 2.8e-17 KT phosphorelay signal transduction system
HEPMHJLG_01060 1.8e-120 agrA KT response regulator
HEPMHJLG_01061 2.1e-148 comD 2.7.13.3 T ATPase histidine kinase DNA gyrase B HSP90 domain protein
HEPMHJLG_01062 1.9e-53
HEPMHJLG_01064 8.5e-11
HEPMHJLG_01065 1.6e-128 V ABC transporter
HEPMHJLG_01066 1e-49
HEPMHJLG_01067 2.2e-123 glnQ E abc transporter atp-binding protein
HEPMHJLG_01068 5.5e-273 glnP P ABC transporter
HEPMHJLG_01069 1.5e-152 uppP 3.6.1.27 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
HEPMHJLG_01070 6.3e-18 S Protein of unknown function (DUF3021)
HEPMHJLG_01071 2e-124 mecA NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
HEPMHJLG_01072 3e-183 tagO 2.7.8.33, 2.7.8.35 M transferase
HEPMHJLG_01073 1.7e-137 sufC O ABC-type transport system involved in Fe-S cluster assembly, ATPase component
HEPMHJLG_01074 1.2e-233 sufD O assembly protein SufD
HEPMHJLG_01075 2.8e-235 sufS 2.8.1.7, 4.4.1.16 E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HEPMHJLG_01076 9.4e-74 nifU C SUF system FeS assembly protein, NifU family
HEPMHJLG_01077 2.9e-273 sufB O assembly protein SufB
HEPMHJLG_01078 2.7e-26
HEPMHJLG_01079 4e-156 hslO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HEPMHJLG_01080 2.8e-182 dus J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HEPMHJLG_01081 2e-71 adcR K transcriptional
HEPMHJLG_01082 2.4e-135 adcC P ABC transporter, ATP-binding protein
HEPMHJLG_01083 3.9e-129 adcB P ABC transporter (Permease
HEPMHJLG_01084 2.9e-160 mleP2 S Transporter, auxin efflux carrier (AEC) family protein
HEPMHJLG_01085 0.0 ptsG 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G pts system
HEPMHJLG_01086 4.6e-154 rgfB 3.1.3.90 L Endonuclease/Exonuclease/phosphatase family
HEPMHJLG_01087 4.2e-253 pgi 5.3.1.9 G Belongs to the GPI family
HEPMHJLG_01088 1.4e-142 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
HEPMHJLG_01089 0.0 srlM 2.7.1.202, 2.7.1.204 GKT Mga helix-turn-helix domain
HEPMHJLG_01090 6.8e-84 gutM K phosphoenolpyruvate-dependent sugar phosphotransferase system
HEPMHJLG_01091 1.1e-95 srlA G PTS system glucitol sorbitol-specific
HEPMHJLG_01092 3.8e-179 srlE 2.7.1.198 G PTS sorbitol transporter subunit IIB
HEPMHJLG_01093 4.2e-59 srlB 2.7.1.198 G sorbitol-specific, IIA component
HEPMHJLG_01094 9.2e-59 L MULE transposase domain
HEPMHJLG_01095 1.1e-108 L Transposase IS116 IS110 IS902
HEPMHJLG_01096 1.3e-305 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
HEPMHJLG_01097 2.2e-219 L the current gene model (or a revised gene model) may contain a frame shift
HEPMHJLG_01098 1.4e-153 Z012_04635 K sequence-specific DNA binding
HEPMHJLG_01099 6.5e-282 V ABC transporter
HEPMHJLG_01100 6.1e-126 yeeN K transcriptional regulatory protein
HEPMHJLG_01101 2.2e-46 yajC U protein transport
HEPMHJLG_01102 5.3e-141 uppS 2.5.1.31 H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HEPMHJLG_01103 9.3e-144 cdsA 2.7.7.41 S Belongs to the CDS family
HEPMHJLG_01104 2.1e-230 rseP 3.4.21.107, 3.4.21.116 M zinc metalloprotease
HEPMHJLG_01105 0.0 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
HEPMHJLG_01106 0.0 WQ51_06230 S ABC transporter
HEPMHJLG_01107 1.4e-142 cmpC S abc transporter atp-binding protein
HEPMHJLG_01108 4.9e-42 groS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HEPMHJLG_01109 1.5e-286 groL O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
HEPMHJLG_01111 1.9e-44
HEPMHJLG_01112 5.8e-55 S TM2 domain
HEPMHJLG_01113 1.3e-159 rluA 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
HEPMHJLG_01114 0.0 pbp2A 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
HEPMHJLG_01115 2.8e-24 secE U Belongs to the SecE SEC61-gamma family
HEPMHJLG_01116 8.4e-96 nusG K Participates in transcription elongation, termination and antitermination
HEPMHJLG_01117 3e-67 3.1.3.27, 3.1.3.4, 3.1.3.81, 3.6.1.27 I phosphatidate phosphatase activity
HEPMHJLG_01118 1.5e-144 cof S Sucrose-6F-phosphate phosphohydrolase
HEPMHJLG_01119 3e-131 glcR K transcriptional regulator (DeoR family)
HEPMHJLG_01120 0.0 leuS 6.1.1.4 J Belongs to the class-I aminoacyl-tRNA synthetase family
HEPMHJLG_01121 1.4e-72 K transcriptional
HEPMHJLG_01122 8e-227 S COG1073 Hydrolases of the alpha beta superfamily
HEPMHJLG_01123 1.2e-41 yjdF S Protein of unknown function (DUF2992)
HEPMHJLG_01124 6.3e-48 3.2.2.21 S YCII-related domain
HEPMHJLG_01125 3.7e-51 K regulation of RNA biosynthetic process
HEPMHJLG_01126 2.2e-154 cylA V abc transporter atp-binding protein
HEPMHJLG_01127 1.6e-133 cylB V ABC-2 type transporter
HEPMHJLG_01128 2.6e-74 K COG3279 Response regulator of the LytR AlgR family
HEPMHJLG_01129 1.4e-29 S Protein of unknown function (DUF3021)
HEPMHJLG_01130 4.9e-120 mta K Transcriptional
HEPMHJLG_01131 8.1e-120 yhcA V abc transporter atp-binding protein
HEPMHJLG_01132 5.9e-206 macB_2 V FtsX-like permease family
HEPMHJLG_01133 5.7e-272 pncB 6.3.4.21 H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HEPMHJLG_01134 1.7e-148 nadE 6.3.1.5 H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
HEPMHJLG_01135 1.1e-77 yhaI S Protein of unknown function (DUF805)
HEPMHJLG_01136 5.8e-255 pepC 3.4.22.40 E aminopeptidase
HEPMHJLG_01137 0.0 ponA 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
HEPMHJLG_01138 4.3e-109 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
HEPMHJLG_01139 5.8e-94 ypsA S Belongs to the UPF0398 family
HEPMHJLG_01140 1.1e-50 gpsB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
HEPMHJLG_01141 1.3e-223 rlmL 2.1.1.173, 2.1.1.264 L Belongs to the methyltransferase superfamily
HEPMHJLG_01142 4e-284 mapZ D Early cell division protein that marks the future cell division site and supports proper FtsZ ring positioning
HEPMHJLG_01143 0.0 snf 2.7.11.1 L Superfamily II DNA RNA helicases, SNF2 family'
HEPMHJLG_01144 9.6e-23
HEPMHJLG_01145 4.7e-257 mpl 6.3.2.4, 6.3.2.45, 6.3.2.8 M Belongs to the MurCDEF family
HEPMHJLG_01146 4.1e-89 XK27_09675 K histone acetyltransferase HPA2 and related acetyltransferases
HEPMHJLG_01147 6.9e-305 mltG ADL Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HEPMHJLG_01148 1.2e-77 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
HEPMHJLG_01149 3.4e-166 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HEPMHJLG_01150 2e-45 acyP 3.6.1.7 C Belongs to the acylphosphatase family
HEPMHJLG_01151 1e-128 spoU 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEPMHJLG_01152 2.5e-94 XK27_09705 6.1.1.14 S HD superfamily hydrolase
HEPMHJLG_01153 6.9e-103 ybhL S Belongs to the BI1 family
HEPMHJLG_01154 8.4e-13 ycdA S Domain of unknown function (DUF4352)
HEPMHJLG_01155 2.1e-243 lysA 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
HEPMHJLG_01156 6.9e-90 K transcriptional regulator
HEPMHJLG_01157 1.6e-36 yneF S UPF0154 protein
HEPMHJLG_01158 1.5e-149 murI 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
HEPMHJLG_01159 3.2e-186 rdgB 3.6.1.66, 5.1.1.3 F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HEPMHJLG_01160 3.9e-98 XK27_09740 S Phosphoesterase
HEPMHJLG_01161 8.3e-87 ykuL S CBS domain
HEPMHJLG_01162 2.7e-132 xerD L tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site
HEPMHJLG_01163 1.8e-122 scpA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HEPMHJLG_01164 6.5e-94 scpB D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HEPMHJLG_01165 3.4e-132 rluB 5.4.99.19, 5.4.99.21, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
HEPMHJLG_01166 1.4e-13 yidD M Could be involved in insertion of integral membrane proteins into the membrane
HEPMHJLG_01167 4.9e-260 trkH P Cation transport protein
HEPMHJLG_01168 1.2e-247 trkA P Potassium transporter peripheral membrane component
HEPMHJLG_01169 6.1e-96 trmL 2.1.1.207 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
HEPMHJLG_01170 3.2e-90 ribU U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HEPMHJLG_01171 2.8e-106 bcrC 3.6.1.27 I Membrane-associated phospholipid phosphatase
HEPMHJLG_01172 1.3e-136 K sequence-specific DNA binding
HEPMHJLG_01173 0.0 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
HEPMHJLG_01174 6.4e-54 yhaI L Membrane
HEPMHJLG_01175 5.7e-92 S Domain of unknown function (DUF4173)
HEPMHJLG_01176 1.5e-94 ureI S AmiS/UreI family transporter
HEPMHJLG_01177 7.6e-46 ureA 3.5.1.5 E Belongs to the urease gamma subunit family
HEPMHJLG_01178 7.8e-54 ureB 3.5.1.5 E Belongs to the urease beta subunit family
HEPMHJLG_01179 0.0 ureC 3.5.1.5 E Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family
HEPMHJLG_01180 2.5e-77 ureE O enzyme active site formation
HEPMHJLG_01181 5.3e-130 ureF O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
HEPMHJLG_01182 3.6e-111 ureG KO Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HEPMHJLG_01183 1.9e-158 ureD O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
HEPMHJLG_01184 3.9e-176 cbiM P biosynthesis protein CbiM
HEPMHJLG_01185 1.4e-136 P cobalt transport protein
HEPMHJLG_01186 2.4e-130 cbiO P ABC transporter
HEPMHJLG_01187 6.3e-138 ET ABC transporter substrate-binding protein
HEPMHJLG_01188 1.4e-164 metQ M Belongs to the NlpA lipoprotein family
HEPMHJLG_01189 2e-263 dapE 3.5.1.18 E COG0624, acetylornithine deacetylase succinyl-diaminopimelate desuccinylase and related deacylases
HEPMHJLG_01190 2.4e-187 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HEPMHJLG_01191 8e-99 metI P ABC transporter (Permease
HEPMHJLG_01192 9.7e-209 sstT E Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HEPMHJLG_01193 1.2e-157 salL 2.5.1.63, 2.5.1.94 S S-adenosyl-l-methionine hydroxide adenosyltransferase
HEPMHJLG_01194 6.7e-93 S UPF0397 protein
HEPMHJLG_01195 4.3e-308 ykoD P abc transporter atp-binding protein
HEPMHJLG_01196 3.2e-147 cbiQ P cobalt transport
HEPMHJLG_01197 4.8e-117 ktrA P COG0569 K transport systems, NAD-binding component
HEPMHJLG_01198 9.8e-234 P COG0168 Trk-type K transport systems, membrane components
HEPMHJLG_01199 5.5e-127 rsmG 2.1.1.170 J Ribosomal RNA small subunit methyltransferase G
HEPMHJLG_01200 3.1e-90 yceD K metal-binding, possibly nucleic acid-binding protein
HEPMHJLG_01201 7.9e-123 T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HEPMHJLG_01202 3.2e-281 T PhoQ Sensor
HEPMHJLG_01203 1.4e-81 nrdR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HEPMHJLG_01204 3.6e-216 dnaB L Replication initiation and membrane attachment
HEPMHJLG_01205 1.5e-166 dnaI L Primosomal protein DnaI
HEPMHJLG_01206 2.6e-247 der 1.1.1.399, 1.1.1.95 S GTPase that plays an essential role in the late steps of ribosome biogenesis
HEPMHJLG_01207 1e-113
HEPMHJLG_01208 1.4e-229 serS 6.1.1.11 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HEPMHJLG_01209 2.5e-62 manO S protein conserved in bacteria
HEPMHJLG_01210 3.3e-169 manN G PTS system mannose fructose sorbose family IID component
HEPMHJLG_01211 1.2e-117 manM G pts system
HEPMHJLG_01212 4e-176 manL 2.7.1.191 G pts system
HEPMHJLG_01213 1e-66 manO S Protein conserved in bacteria
HEPMHJLG_01214 2.8e-160 manN G PTS system mannose fructose sorbose family IID component
HEPMHJLG_01215 4.8e-132 manY G pts system
HEPMHJLG_01216 2.4e-168 manL 2.7.1.191 G pts system
HEPMHJLG_01217 3.2e-138 XK27_00940 1.2.1.70, 3.5.1.9 S Metal-dependent hydrolase
HEPMHJLG_01218 3.5e-154 yitU 3.1.3.104 S hydrolases of the HAD superfamily
HEPMHJLG_01219 3.6e-247 pbuO S permease
HEPMHJLG_01220 4.7e-76 ydiB 2.7.1.221, 5.1.1.1 M ATPase or kinase
HEPMHJLG_01221 6e-91 XK27_05885 2.3.1.82 M phosphinothricin N-acetyltransferase activity
HEPMHJLG_01222 4.4e-188 brpA K Transcriptional
HEPMHJLG_01223 2.3e-81 rimP S Required for maturation of 30S ribosomal subunits
HEPMHJLG_01224 2.4e-196 nusA K Participates in both transcription termination and antitermination
HEPMHJLG_01225 1e-47 ylxR K Nucleic-acid-binding protein implicated in transcription termination
HEPMHJLG_01226 8e-42 ylxQ J ribosomal protein
HEPMHJLG_01227 0.0 infB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HEPMHJLG_01228 8.6e-57 rbfA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HEPMHJLG_01229 2.9e-99 yvdD 3.2.2.10 S Belongs to the LOG family
HEPMHJLG_01230 1.9e-272 murE 6.3.2.13, 6.3.2.7 M to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HEPMHJLG_01231 1.3e-282 ytgP S Membrane protein involved in the export of O-antigen and teichoic acid
HEPMHJLG_01232 0.0 pacL 3.6.3.8, 3.6.3.9 P cation transport ATPase
HEPMHJLG_01233 5.1e-201 metB 2.5.1.48, 4.4.1.8 E cystathionine
HEPMHJLG_01234 1.5e-222 malY 4.4.1.8 E COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
HEPMHJLG_01235 0.0 3.2.1.26, 3.2.1.65 GH32 G Belongs to the glycosyl hydrolase 32 family
HEPMHJLG_01236 0.0 sacB 2.4.1.10, 2.4.1.9, 3.2.1.26 GH32,GH68 G Belongs to the glycosyl hydrolase 68 family
HEPMHJLG_01237 5.7e-112 upp 2.4.2.9 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HEPMHJLG_01238 3.7e-105 clpP 3.4.21.92 OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
HEPMHJLG_01239 9.8e-74 ylbF S Belongs to the UPF0342 family
HEPMHJLG_01240 1.9e-46 ylbG S UPF0298 protein
HEPMHJLG_01241 1.4e-212 livJ E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component
HEPMHJLG_01242 4.2e-145 livH E Belongs to the binding-protein-dependent transport system permease family
HEPMHJLG_01243 8.3e-139 livM E Belongs to the binding-protein-dependent transport system permease family
HEPMHJLG_01244 2.4e-136 livG E COG0411 ABC-type branched-chain amino acid transport systems, ATPase component
HEPMHJLG_01245 5.6e-124 livF E COG0410 ABC-type branched-chain amino acid transport systems, ATPase component
HEPMHJLG_01246 7.1e-113 acuB S CBS domain
HEPMHJLG_01247 6.3e-168 cysK 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
HEPMHJLG_01248 3.2e-107 yvyE 3.4.13.9 S YigZ family
HEPMHJLG_01249 7.5e-247 comFA L Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HEPMHJLG_01250 1e-82 comFC K competence protein
HEPMHJLG_01251 1.6e-94 hpf J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HEPMHJLG_01252 2.5e-118 L PFAM Integrase, catalytic core
HEPMHJLG_01253 7e-56 nrdD_1 1.1.98.6, 1.17.4.1 F Ribonucleoside-triphosphate reductase
HEPMHJLG_01255 0.0 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HEPMHJLG_01256 8.4e-93 paiA 2.3.1.57 K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HEPMHJLG_01257 6.6e-198 pheS 6.1.1.20 J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HEPMHJLG_01258 2.9e-22 WQ51_00220 K Helix-turn-helix domain
HEPMHJLG_01259 1e-93 S Protein of unknown function (DUF3278)
HEPMHJLG_01260 0.0 smc D Required for chromosome condensation and partitioning
HEPMHJLG_01261 2.5e-124 rnc 3.1.26.3 J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
HEPMHJLG_01262 1.7e-173 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEPMHJLG_01263 1.6e-199 asd 1.2.1.11 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HEPMHJLG_01264 1.8e-124 alkD L Dna alkylation repair
HEPMHJLG_01265 1.5e-299 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEPMHJLG_01266 1.1e-92 pat 2.3.1.183 M acetyltransferase
HEPMHJLG_01267 9.4e-272 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEPMHJLG_01268 0.0 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
HEPMHJLG_01269 2.8e-128 yjjG 3.1.3.102, 3.1.3.104, 3.1.3.5, 3.8.1.2 E hydrolase
HEPMHJLG_01270 8.8e-119 sdaAB 4.3.1.17 E L-serine dehydratase
HEPMHJLG_01271 3.4e-147 sdaAA 4.3.1.17 E L-serine dehydratase
HEPMHJLG_01272 0.0 fruA 3.2.1.1, 3.2.1.26, 3.2.1.65, 3.2.1.80 GH13,GH32 G Belongs to the glycosyl hydrolase 32 family
HEPMHJLG_01273 6.7e-162 yjlA EG membrane
HEPMHJLG_01274 1.3e-80 3.4.21.89 S RDD family
HEPMHJLG_01275 7.5e-49
HEPMHJLG_01276 1.7e-88
HEPMHJLG_01277 2.3e-24
HEPMHJLG_01279 7.4e-30
HEPMHJLG_01280 9e-116
HEPMHJLG_01283 7.3e-85 yfjR K regulation of single-species biofilm formation
HEPMHJLG_01284 3.9e-125 S Protein of unknown function DUF262
HEPMHJLG_01285 4.5e-203 S Protein of unknown function DUF262
HEPMHJLG_01286 3.9e-102 desR K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HEPMHJLG_01287 3.2e-187 desK 2.7.13.3 T Histidine kinase
HEPMHJLG_01288 5.3e-133 yvfS V ABC-2 type transporter
HEPMHJLG_01289 6.7e-159 XK27_09825 V 'abc transporter, ATP-binding protein
HEPMHJLG_01292 3.3e-164 yocS S Transporter
HEPMHJLG_01293 3.1e-83 cdd 2.4.2.4, 3.5.4.5 F cytidine deaminase activity
HEPMHJLG_01294 1.7e-115 yvfS V Transporter
HEPMHJLG_01295 9.7e-158 XK27_09825 V abc transporter atp-binding protein
HEPMHJLG_01296 3.7e-16 liaI KT membrane
HEPMHJLG_01297 2.2e-29 liaI KT membrane
HEPMHJLG_01298 2.3e-92 XK27_05000 S metal cluster binding
HEPMHJLG_01299 0.0 V ABC transporter (permease)
HEPMHJLG_01300 1.1e-133 macB2 V ABC transporter, ATP-binding protein
HEPMHJLG_01301 2.2e-147 T Histidine kinase
HEPMHJLG_01302 5.4e-124 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HEPMHJLG_01303 2.5e-98 xpt 2.4.2.22, 2.4.2.7 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
HEPMHJLG_01304 3.8e-224 pbuX F xanthine permease
HEPMHJLG_01305 4.5e-59 pdxH S pyridoxamine 5'-phosphate oxidase
HEPMHJLG_01306 1.2e-270 V (ABC) transporter
HEPMHJLG_01307 2.6e-152 K sequence-specific DNA binding
HEPMHJLG_01308 8.7e-243 norM V Multidrug efflux pump
HEPMHJLG_01310 2e-180 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HEPMHJLG_01311 8.9e-232 brnQ E Component of the transport system for branched-chain amino acids
HEPMHJLG_01312 1e-181 manA 5.3.1.8 G mannose-6-phosphate isomerase
HEPMHJLG_01313 1.8e-59 S Protein of unknown function (DUF3290)
HEPMHJLG_01314 1.5e-107 S Protein of unknown function (DUF421)
HEPMHJLG_01315 1.4e-16 csbD S CsbD-like
HEPMHJLG_01316 3e-122 S Carbohydrate-binding domain-containing protein Cthe_2159
HEPMHJLG_01317 3e-51 XK27_01300 S ASCH
HEPMHJLG_01318 7.2e-216 yfnA E amino acid
HEPMHJLG_01319 0.0 S dextransucrase activity
HEPMHJLG_01320 4.3e-138 tcyC2 3.6.3.21 E abc transporter atp-binding protein
HEPMHJLG_01321 4.3e-113 yxeN P ABC transporter, permease protein
HEPMHJLG_01322 1.3e-109 ytmL P ABC transporter (Permease
HEPMHJLG_01323 6.1e-165 ET ABC transporter substrate-binding protein
HEPMHJLG_01324 2.9e-174 4.1.1.37 H Uroporphyrinogen decarboxylase (URO-D)
HEPMHJLG_01325 1.1e-83 btuE 1.11.1.9 O Belongs to the glutathione peroxidase family
HEPMHJLG_01326 1.5e-42 S Sugar efflux transporter for intercellular exchange
HEPMHJLG_01327 4.4e-203 P FtsX-like permease family
HEPMHJLG_01328 3.9e-122 V abc transporter atp-binding protein
HEPMHJLG_01329 4e-96 K WHG domain
HEPMHJLG_01330 1.2e-169 ydhF S Aldo keto reductase
HEPMHJLG_01331 2.1e-211 natB CP ABC-type Na efflux pump, permease component
HEPMHJLG_01332 9.8e-166 natA S abc transporter atp-binding protein
HEPMHJLG_01333 1.1e-09 S Protein of unknown function (DUF3169)
HEPMHJLG_01334 5.5e-27 XK27_07105 K transcriptional
HEPMHJLG_01335 1.3e-35
HEPMHJLG_01336 2.2e-108 XK27_02070 S nitroreductase
HEPMHJLG_01337 1.5e-152 1.13.11.2 S glyoxalase
HEPMHJLG_01338 4.7e-76 ywnA K Transcriptional regulator
HEPMHJLG_01339 4.9e-154 E Alpha/beta hydrolase of unknown function (DUF915)
HEPMHJLG_01340 1.2e-225 pts13C G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HEPMHJLG_01341 1.7e-168 bcrA V abc transporter atp-binding protein
HEPMHJLG_01342 6.8e-128 S ABC-2 family transporter protein
HEPMHJLG_01343 4.3e-45 S Domain of unknown function (DUF4352)
HEPMHJLG_01344 3.4e-147 T PhoQ Sensor
HEPMHJLG_01345 2.1e-123 T Xre family transcriptional regulator
HEPMHJLG_01346 4.1e-110 drgA C nitroreductase
HEPMHJLG_01347 1.6e-107 yoaK S Protein of unknown function (DUF1275)
HEPMHJLG_01348 7.6e-39 DJ nuclease activity
HEPMHJLG_01349 3.2e-30 XK27_10490
HEPMHJLG_01350 1.2e-157 yvgN C reductase
HEPMHJLG_01351 1.4e-209 S Tetratricopeptide repeat
HEPMHJLG_01352 0.0 lacL 3.2.1.23 G -beta-galactosidase
HEPMHJLG_01353 0.0 lacS G transporter
HEPMHJLG_01354 4.2e-200 galM 5.1.3.3 G Catalyzes the interconversion of alpha and beta anomers of maltose
HEPMHJLG_01355 1.1e-194 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
HEPMHJLG_01356 6.5e-287 galT 2.7.7.12 G UDPglucose--hexose-1-phosphate uridylyltransferase
HEPMHJLG_01357 5.6e-222 galK 2.7.1.6 G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HEPMHJLG_01358 2e-175 galR K Transcriptional regulator
HEPMHJLG_01359 3.9e-306 dexB 3.2.1.10, 3.2.1.70 GH13 G COG0366 Glycosidases
HEPMHJLG_01360 2.9e-227 vncS 2.7.13.3 T Histidine kinase
HEPMHJLG_01361 2e-115 K Response regulator receiver domain protein
HEPMHJLG_01362 7.8e-239 vex3 V Efflux ABC transporter, permease protein
HEPMHJLG_01363 1.9e-107 vex2 V abc transporter atp-binding protein
HEPMHJLG_01364 5.3e-210 vex1 V Efflux ABC transporter, permease protein
HEPMHJLG_01365 1.2e-282 XK27_07020 S Belongs to the UPF0371 family
HEPMHJLG_01367 9.7e-200 gldA 1.1.1.6 C glycerol dehydrogenase
HEPMHJLG_01368 1e-176 XK27_10475 S oxidoreductase
HEPMHJLG_01369 6.3e-58 dhaM 2.7.1.121 S dihydroxyacetone kinase, phosphotransfer subunit
HEPMHJLG_01370 4.5e-95 dhaL 2.7.1.121 S Dihydroxyacetone kinase
HEPMHJLG_01371 1.7e-179 dhaK 2.7.1.121, 2.7.1.28, 2.7.1.29, 4.6.1.15 G Dihydroxyacetone kinase
HEPMHJLG_01372 2.8e-227 thrE K Psort location CytoplasmicMembrane, score
HEPMHJLG_01373 0.0 M Putative cell wall binding repeat
HEPMHJLG_01374 4.1e-34 S Immunity protein 41
HEPMHJLG_01375 0.0 pepO 3.4.24.71 O Peptidase family M13
HEPMHJLG_01376 2.4e-08 S Enterocin A Immunity
HEPMHJLG_01377 1.3e-190 mccF V LD-carboxypeptidase
HEPMHJLG_01378 1e-14 S integral membrane protein
HEPMHJLG_01379 4.2e-43 czrA K helix_turn_helix, Arsenical Resistance Operon Repressor
HEPMHJLG_01380 1.5e-116 yhfC S Putative membrane peptidase family (DUF2324)
HEPMHJLG_01381 0.0 2.4.1.5 GH13 M KxYKxGKxW signal domain protein
HEPMHJLG_01383 1.2e-227 S dextransucrase activity
HEPMHJLG_01384 0.0 2.4.1.5 GH13 M KxYKxGKxW signal domain protein
HEPMHJLG_01385 0.0 S dextransucrase activity
HEPMHJLG_01386 0.0 S dextransucrase activity
HEPMHJLG_01387 0.0 S dextransucrase activity
HEPMHJLG_01388 0.0 M Putative cell wall binding repeat
HEPMHJLG_01389 1.6e-237 tcdB S dextransucrase activity
HEPMHJLG_01390 0.0 S dextransucrase activity
HEPMHJLG_01391 2.1e-103 pdxT 4.3.3.6 H Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HEPMHJLG_01392 1.8e-156 pdxS 4.3.3.6 H Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HEPMHJLG_01393 0.0 M Putative cell wall binding repeat
HEPMHJLG_01394 1.1e-302 S dextransucrase activity
HEPMHJLG_01395 0.0 S dextransucrase activity
HEPMHJLG_01396 0.0 S dextransucrase activity
HEPMHJLG_01398 3.6e-99 XK27_00785 S CAAX protease self-immunity
HEPMHJLG_01399 3.5e-239 EGP Major facilitator Superfamily
HEPMHJLG_01400 1.8e-66 rmaI K Transcriptional regulator, MarR family
HEPMHJLG_01401 6.7e-88 maa 2.3.1.79 GK Maltose O-acetyltransferase
HEPMHJLG_01402 6.1e-137 S N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity
HEPMHJLG_01403 0.0 3.5.1.28 M domain protein
HEPMHJLG_01404 0.0 2.4.1.5 GH13 M KxYKxGKxW signal domain protein
HEPMHJLG_01405 1.5e-109 K Helix-turn-helix domain, rpiR family
HEPMHJLG_01406 1.5e-17 3.2.1.51 GH95 U LPXTG cell wall anchor motif
HEPMHJLG_01407 0.0 2.4.1.5 GH13 M KxYKxGKxW signal domain protein
HEPMHJLG_01408 0.0 2.4.1.5 GH13 M KxYKxGKxW signal domain protein
HEPMHJLG_01409 1.1e-87 XK27_08075 M glycosyl transferase family 2
HEPMHJLG_01410 1.2e-72 XK27_08075 M glycosyl transferase family 2
HEPMHJLG_01411 4.9e-102 S Carbohydrate-binding domain-containing protein Cthe_2159
HEPMHJLG_01412 2.9e-142 P molecular chaperone
HEPMHJLG_01413 2.2e-93 XK27_05505 S Psort location CytoplasmicMembrane, score
HEPMHJLG_01416 4.1e-50 hisE 3.5.4.19, 3.6.1.31, 5.3.1.16 E phosphoribosyl-ATP diphosphatase activity
HEPMHJLG_01417 3.6e-60 hisI 3.5.4.19, 3.5.4.25, 3.6.1.31, 5.3.1.16 E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HEPMHJLG_01418 3.6e-137 hisF 3.5.4.19, 3.6.1.31 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
HEPMHJLG_01419 2.4e-130 hisA 5.3.1.16 E 1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HEPMHJLG_01420 2.3e-110 hisH E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HEPMHJLG_01421 1.1e-106 hisB 1.1.1.23, 2.6.1.9, 3.1.3.15, 4.2.1.19 E imidazoleglycerol-phosphate dehydratase
HEPMHJLG_01422 1.4e-234 hisD 1.1.1.23, 1.1.1.308 E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HEPMHJLG_01423 5.5e-118 hisG 2.4.2.17 E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
HEPMHJLG_01424 5.5e-178 hisZ 2.4.2.17, 6.1.1.21 E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HEPMHJLG_01425 4.2e-192 hisC 2.6.1.9 E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEPMHJLG_01426 1.8e-60 XK27_08085
HEPMHJLG_01427 4.7e-147 XK27_08080 3.1.1.53 G Exopolysaccharide biosynthesis protein
HEPMHJLG_01428 6.7e-136 hisK 3.1.3.15 E Histidinol phosphatase and related hydrolases of the PHP family
HEPMHJLG_01429 3.9e-116 ylfI S tigr01906
HEPMHJLG_01430 1e-139 nagD 2.7.1.25, 3.1.3.41 G Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
HEPMHJLG_01431 1.4e-141 fat 3.1.2.21 I Acyl-ACP thioesterase
HEPMHJLG_01432 8.2e-218 hemN H Involved in the biosynthesis of porphyrin-containing compound
HEPMHJLG_01433 3.7e-30 KT response to antibiotic
HEPMHJLG_01435 1.3e-204 rfbB 4.2.1.46 M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
HEPMHJLG_01436 2.7e-111 rmlC 1.1.1.133, 5.1.3.13 M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
HEPMHJLG_01437 2.4e-161 rfbA 2.7.7.24 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HEPMHJLG_01438 7.4e-258 S phospholipase Carboxylesterase
HEPMHJLG_01439 1.1e-200 yurR 1.4.5.1 E oxidoreductase
HEPMHJLG_01440 8e-146 zupT P Mediates zinc uptake. May also transport other divalent cations
HEPMHJLG_01441 2.2e-145 yqfO 3.5.4.16 S Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HEPMHJLG_01442 2.6e-118 trmK 2.1.1.217 S SAM-dependent methyltransferase
HEPMHJLG_01443 5e-64 gtrA S GtrA-like protein
HEPMHJLG_01444 1.3e-249 glmM 5.4.2.10 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEPMHJLG_01445 6e-169 ybbR S Protein conserved in bacteria
HEPMHJLG_01446 1.5e-147 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HEPMHJLG_01447 4.5e-252 murD 3.4.21.10, 6.3.2.13, 6.3.2.9 M Mur ligase, middle domain protein
HEPMHJLG_01448 2.3e-150 cobQ S glutamine amidotransferase
HEPMHJLG_01449 0.0 mprF 2.3.2.3 J Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HEPMHJLG_01450 2e-132 pip 1.11.1.10 S Alpha beta hydrolase
HEPMHJLG_01451 5.3e-34 MA20_06245 S yiaA/B two helix domain
HEPMHJLG_01452 0.0 uup S abc transporter atp-binding protein
HEPMHJLG_01453 6.2e-114 udk 2.7.1.48 F Cytidine monophosphokinase
HEPMHJLG_01454 3.2e-179 yfmL 3.6.4.13 L DEAD DEAH box helicase
HEPMHJLG_01455 9.9e-227 XK27_05680 6.3.2.2, 6.3.2.4 M carbamoylphosphate synthase large subunit
HEPMHJLG_01456 2.7e-153 XK27_05675 S Esterase
HEPMHJLG_01457 6.1e-162 XK27_05670 S Putative esterase
HEPMHJLG_01458 1.1e-264 gapN 1.2.1.9 C Belongs to the aldehyde dehydrogenase family
HEPMHJLG_01459 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEPMHJLG_01460 3e-38 ptsH G phosphocarrier protein Hpr
HEPMHJLG_01461 9.7e-222 icd 1.1.1.42 C Isocitrate dehydrogenase
HEPMHJLG_01462 2.5e-211 citZ 2.3.3.1 C Belongs to the citrate synthase family
HEPMHJLG_01463 0.0 acnA 4.2.1.3 C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HEPMHJLG_01464 2.9e-34 nrdH O Glutaredoxin
HEPMHJLG_01465 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HEPMHJLG_01466 8.5e-184 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HEPMHJLG_01467 0.0 ileS 6.1.1.5 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HEPMHJLG_01468 8.4e-138 divIVA D Cell division initiation protein
HEPMHJLG_01469 2.7e-143 ylmH S conserved protein, contains S4-like domain
HEPMHJLG_01470 6.5e-30 yggT D integral membrane protein
HEPMHJLG_01471 3.2e-101 sepF D cell septum assembly
HEPMHJLG_01472 2.1e-123 ylmE S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HEPMHJLG_01473 1.7e-238 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HEPMHJLG_01474 7.1e-224 ftsA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
HEPMHJLG_01475 2.2e-133 divIB D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
HEPMHJLG_01476 1.9e-200 murG 2.4.1.227 GT28 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HEPMHJLG_01477 1e-251 murD 6.3.2.9 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HEPMHJLG_01479 0.0 typA T GTP-binding protein TypA
HEPMHJLG_01480 3.5e-177 glk 2.7.1.2 G Glucokinase
HEPMHJLG_01481 2.4e-27 yqgQ S protein conserved in bacteria
HEPMHJLG_01482 5.2e-83 perR P Belongs to the Fur family
HEPMHJLG_01483 9.3e-92 dps P Belongs to the Dps family
HEPMHJLG_01484 7.5e-115 pilD 3.4.23.43 NOU Type II secretory pathway prepilin signal peptidase PulO and related peptidases
HEPMHJLG_01485 3.6e-172 3.5.2.6 V D-alanyl-D-alanine carboxypeptidase
HEPMHJLG_01486 9.4e-112 sodA 1.15.1.1 C radicals which are normally produced within the cells and which are toxic to biological systems
HEPMHJLG_01487 1.4e-184 holA 2.7.7.7 L DNA polymerase III delta subunit
HEPMHJLG_01488 0.0 ppc 4.1.1.31 H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HEPMHJLG_01489 4.8e-64 S Domain of unknown function (DUF4430)
HEPMHJLG_01490 6.7e-73 S Psort location CytoplasmicMembrane, score
HEPMHJLG_01491 6e-129 sitB 3.6.3.35 P ABC transporter, ATP-binding protein
HEPMHJLG_01492 2.1e-133 mtsC P ABC-type Mn2 Zn2 transport systems, permease components
HEPMHJLG_01493 3.9e-165 sitA P Belongs to the bacterial solute-binding protein 9 family
HEPMHJLG_01494 1.1e-118 sirR K iron dependent repressor
HEPMHJLG_01495 1.5e-134 htpX O Belongs to the peptidase M48B family
HEPMHJLG_01496 1.2e-92 lemA S LemA family
HEPMHJLG_01497 2.4e-176 spd F DNA RNA non-specific endonuclease
HEPMHJLG_01498 0.0 2.4.1.21 GT5 M Right handed beta helix region
HEPMHJLG_01500 1.9e-135 S double-stranded DNA endodeoxyribonuclease activity
HEPMHJLG_01501 1.8e-303 hsdM 2.1.1.72 V type I restriction-modification system
HEPMHJLG_01502 2.3e-123 S Protein conserved in bacteria
HEPMHJLG_01503 2.9e-188 S KAP family P-loop domain
HEPMHJLG_01504 1.3e-88 hsdS 3.1.21.3 V type I restriction modification DNA specificity domain
HEPMHJLG_01505 1.7e-12
HEPMHJLG_01506 2.4e-133 L Reverse transcriptase (RNA-dependent DNA polymerase)
HEPMHJLG_01507 0.0 hsdR 3.1.21.3 L Subunit R is required for both nuclease and ATPase activities, but not for modification
HEPMHJLG_01509 2e-130 sdh 1.1.1.276, 1.1.1.313, 1.1.1.381 S Belongs to the short-chain dehydrogenases reductases (SDR) family
HEPMHJLG_01510 2.7e-216 MA20_36090 S Protein of unknown function (DUF2974)
HEPMHJLG_01511 5.2e-113 1.14.14.5 C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEPMHJLG_01512 5.7e-55 5.2.1.8 G hydrolase
HEPMHJLG_01513 1.6e-69 5.2.1.8 G hydrolase
HEPMHJLG_01514 5.3e-27 P Hemerythrin HHE cation binding domain protein
HEPMHJLG_01515 4.8e-144 XK27_00880 3.4.17.14, 3.5.1.28 M Glycosyl hydrolase, family 25
HEPMHJLG_01516 1e-81 ybaK S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HEPMHJLG_01517 4.3e-115 pgm6 5.4.2.11, 5.4.2.12 G Phosphoglycerate mutase
HEPMHJLG_01518 1.5e-174 S hydrolase
HEPMHJLG_01519 8.4e-23
HEPMHJLG_01520 4.6e-137 M LysM domain
HEPMHJLG_01521 8.3e-287 lysS 6.1.1.6 J Belongs to the class-II aminoacyl-tRNA synthetase family
HEPMHJLG_01523 8.7e-235 mntH P H( )-stimulated, divalent metal cation uptake system
HEPMHJLG_01524 1.8e-33 XK27_12190 S protein conserved in bacteria
HEPMHJLG_01526 1e-88 bioY S biotin synthase
HEPMHJLG_01527 4.4e-252 yegQ O Peptidase U32
HEPMHJLG_01528 6.8e-178 yegQ O Peptidase U32
HEPMHJLG_01530 3e-67 ytxH S General stress protein
HEPMHJLG_01531 3.7e-08 WQ51_05790 S protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HEPMHJLG_01532 1.2e-146 lgt 2.1.1.199 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HEPMHJLG_01533 2.2e-168 hprK F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HEPMHJLG_01534 2.9e-41 pspC KT PspC domain
HEPMHJLG_01535 0.0 yhgF K Transcriptional accessory protein
HEPMHJLG_01537 1.9e-156 XK27_03015 S permease
HEPMHJLG_01538 2.4e-147 ycgQ S TIGR03943 family
HEPMHJLG_01539 5.5e-168 S CRISPR-associated protein Csn2 subfamily St
HEPMHJLG_01540 3.1e-53 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HEPMHJLG_01541 3.5e-171 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HEPMHJLG_01542 0.0 cas9 L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
HEPMHJLG_01543 1.1e-284 sulP P Sulfate permease and related transporters (MFS superfamily)
HEPMHJLG_01544 3.6e-103
HEPMHJLG_01545 2.9e-119 estA E GDSL-like Lipase/Acylhydrolase
HEPMHJLG_01546 2.3e-94 S CAAX protease self-immunity
HEPMHJLG_01547 3e-49
HEPMHJLG_01549 2.8e-63 yqeB S Pyrimidine dimer DNA glycosylase
HEPMHJLG_01550 4.1e-60 S Protein of unknown function (DUF1722)
HEPMHJLG_01551 1.3e-19 M Bacterial lipoprotein
HEPMHJLG_01552 1.2e-10
HEPMHJLG_01553 2.8e-126 V CAAX protease self-immunity
HEPMHJLG_01554 7.1e-47
HEPMHJLG_01555 3.4e-74 K TetR family transcriptional regulator
HEPMHJLG_01556 4.2e-80 Q Methyltransferase domain
HEPMHJLG_01557 1e-141 acoC 2.3.1.12, 2.3.1.61 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
HEPMHJLG_01558 1.3e-174 acoB C dehydrogenase E1 component
HEPMHJLG_01559 3.6e-167 acoA C Acetoin dehydrogenase E1 component subunit alpha
HEPMHJLG_01560 9.5e-173 pdhD 1.8.1.4 C Dehydrogenase
HEPMHJLG_01561 3.3e-08 K CsbD-like
HEPMHJLG_01562 7.7e-68 S Asp23 family, cell envelope-related function
HEPMHJLG_01563 1.5e-22 S Small integral membrane protein
HEPMHJLG_01564 4.7e-97
HEPMHJLG_01565 2.3e-29 S Membrane
HEPMHJLG_01567 4.7e-172 S Domain of unknown function (DUF389)
HEPMHJLG_01568 1.3e-157 yegS 2.7.1.107 I Diacylglycerol kinase
HEPMHJLG_01569 3.4e-126 ybbA S Putative esterase
HEPMHJLG_01570 2.9e-174 fatB P COG0614 ABC-type Fe3 -hydroxamate transport system, periplasmic component
HEPMHJLG_01571 9.8e-135 fecE 3.6.3.34 HP ABC transporter
HEPMHJLG_01572 3.9e-158 fecD P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEPMHJLG_01573 4.6e-116 V CAAX protease self-immunity
HEPMHJLG_01574 1.2e-152 S Domain of unknown function (DUF4300)
HEPMHJLG_01575 6.3e-91 tetR K transcriptional regulator
HEPMHJLG_01576 1.5e-282 norB P Major facilitator superfamily
HEPMHJLG_01577 0.0 yjcE P NhaP-type Na H and K H antiporters
HEPMHJLG_01579 1e-96 ytqB 2.1.1.176 J (SAM)-dependent
HEPMHJLG_01580 8.4e-184 yhcC S radical SAM protein
HEPMHJLG_01581 4.2e-187 ylbL T Belongs to the peptidase S16 family
HEPMHJLG_01582 8.6e-87 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HEPMHJLG_01583 1.9e-92 rsmD 2.1.1.171 L Methyltransferase
HEPMHJLG_01584 8e-171 trxB 1.8.1.9 C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
HEPMHJLG_01585 5e-10 S Protein of unknown function (DUF4059)
HEPMHJLG_01586 1.2e-129 tcyN 3.6.3.21 E abc transporter atp-binding protein
HEPMHJLG_01587 8e-163 yxeN P ABC transporter (Permease
HEPMHJLG_01588 3.7e-151 yxeM ET ABC-type amino acid transport signal transduction systems, periplasmic component domain
HEPMHJLG_01589 3.6e-35
HEPMHJLG_01590 3.6e-202 dinB 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HEPMHJLG_01591 0.0 pflB 2.3.1.54 C formate acetyltransferase'
HEPMHJLG_01593 0.0 lai 4.2.1.53 S Myosin-crossreactive antigen
HEPMHJLG_01594 4.4e-146 cah 4.2.1.1 P carbonic anhydrase
HEPMHJLG_01595 4.8e-76 yjcF S COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HEPMHJLG_01597 2.2e-176 ampC V COG1680 Beta-lactamase class C and other penicillin binding proteins
HEPMHJLG_01598 1.6e-140 cppA E CppA N-terminal
HEPMHJLG_01599 4.5e-107 V CAAX protease self-immunity
HEPMHJLG_01600 2e-163 gla U Belongs to the MIP aquaporin (TC 1.A.8) family
HEPMHJLG_01601 0.0 pepX 3.4.14.11 E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline
HEPMHJLG_01602 5.2e-07
HEPMHJLG_01612 0.0 mdlB V abc transporter atp-binding protein
HEPMHJLG_01613 0.0 mdlA V abc transporter atp-binding protein
HEPMHJLG_01616 1.3e-93 XK27_09885 V Glycopeptide antibiotics resistance protein
HEPMHJLG_01617 1.8e-223 rlmN 2.1.1.192 J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HEPMHJLG_01618 4.7e-65 yutD J protein conserved in bacteria
HEPMHJLG_01619 1.3e-257 yunD 3.1.3.5 F Belongs to the 5'-nucleotidase family
HEPMHJLG_01622 7.2e-221 cshB 3.6.4.13 JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
HEPMHJLG_01623 1.7e-182 mraY 2.7.8.13 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HEPMHJLG_01624 0.0 ftsI 3.4.16.4 M penicillin-binding protein
HEPMHJLG_01625 2.4e-45 ftsL D cell division protein FtsL
HEPMHJLG_01626 3.9e-173 rsmH 2.1.1.199 J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
HEPMHJLG_01629 5e-69 yhaI J Protein of unknown function (DUF805)
HEPMHJLG_01630 3.1e-63 yhaI S Protein of unknown function (DUF805)
HEPMHJLG_01631 1.1e-199 proA 1.2.1.41 E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HEPMHJLG_01632 1.3e-140 proB 2.7.2.11 E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HEPMHJLG_01633 2.4e-252 XK27_00765
HEPMHJLG_01634 3.4e-132 ecsA_2 V abc transporter atp-binding protein
HEPMHJLG_01635 2.3e-125 S Protein of unknown function (DUF554)
HEPMHJLG_01636 0.0 addA 3.6.4.12 L ATP-dependent helicase nuclease subunit A
HEPMHJLG_01637 0.0 rexB 3.1.21.3, 3.6.4.12 L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HEPMHJLG_01638 8.6e-246 2.7.13.3 T protein histidine kinase activity
HEPMHJLG_01639 1.1e-242 dcuS 2.7.13.3 T protein histidine kinase activity
HEPMHJLG_01640 8.9e-14
HEPMHJLG_01643 1.3e-145 V Psort location CytoplasmicMembrane, score
HEPMHJLG_01645 9.2e-300 O MreB/Mbl protein
HEPMHJLG_01646 2.6e-194 mccF V LD-carboxypeptidase
HEPMHJLG_01647 4e-43 S Sugar efflux transporter for intercellular exchange
HEPMHJLG_01648 5.6e-77 mccF V LD-carboxypeptidase
HEPMHJLG_01649 8.2e-120 liaI S membrane
HEPMHJLG_01650 5.7e-74 XK27_02470 K LytTr DNA-binding domain
HEPMHJLG_01651 2.2e-307 KT response to antibiotic
HEPMHJLG_01652 2.6e-110 yebC M Membrane
HEPMHJLG_01653 1.8e-259 XK27_03190 S hydrolases of the HAD superfamily
HEPMHJLG_01654 4.6e-177 ansA 3.5.1.1 EJ COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D
HEPMHJLG_01656 6.8e-156 K Helix-turn-helix XRE-family like proteins
HEPMHJLG_01657 1.2e-280 V ABC transporter transmembrane region
HEPMHJLG_01658 2.9e-31 yozG K Transcriptional regulator
HEPMHJLG_01662 0.0 recG 3.6.4.12 L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HEPMHJLG_01663 8.8e-201 alr 5.1.1.1, 5.1.1.5 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HEPMHJLG_01664 3.4e-61 acpS 2.7.6.3, 2.7.8.7, 5.1.1.1 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
HEPMHJLG_01665 5.5e-197 aroF 2.5.1.54 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HEPMHJLG_01666 3.3e-197 aroF 2.5.1.54 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HEPMHJLG_01667 0.0 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
HEPMHJLG_01669 3.7e-187 manA 5.3.1.8 G mannose-6-phosphate isomerase
HEPMHJLG_01670 7e-172 scrK 2.7.1.2, 2.7.1.4 GK Fructokinase
HEPMHJLG_01671 0.0 scrA 2.7.1.201, 2.7.1.208, 2.7.1.211 G pts system
HEPMHJLG_01672 5.1e-289 scrB 3.2.1.26, 3.2.1.80 GH32 G invertase
HEPMHJLG_01673 4.4e-180 scrR K Transcriptional regulator
HEPMHJLG_01674 8.1e-73 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HEPMHJLG_01675 1.7e-61 yqhY S protein conserved in bacteria
HEPMHJLG_01676 1.2e-97 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HEPMHJLG_01677 3.3e-85 comEB 3.5.4.12 F ComE operon protein 2
HEPMHJLG_01678 5.4e-187 pepP 3.4.11.9, 3.4.13.9 E Belongs to the peptidase M24B family
HEPMHJLG_01680 2.8e-32 blpT
HEPMHJLG_01684 0.0 uvrA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HEPMHJLG_01685 4.2e-167 corA P COG0598 Mg2 and Co2 transporters
HEPMHJLG_01686 1.3e-122 XK27_01040 S Protein of unknown function (DUF1129)
HEPMHJLG_01688 1.7e-35 rpsR J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HEPMHJLG_01689 2.5e-81 ssb L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
HEPMHJLG_01690 2.3e-47 rpsF J Binds together with S18 to 16S ribosomal RNA
HEPMHJLG_01691 4.2e-42 XK27_05745
HEPMHJLG_01692 3.4e-227 mutY L A G-specific adenine glycosylase
HEPMHJLG_01695 1.3e-37
HEPMHJLG_01696 0.0 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HEPMHJLG_01697 1.9e-93 salR K helix_turn_helix, Lux Regulon
HEPMHJLG_01698 5.9e-275 2.7.13.3 T Histidine kinase
HEPMHJLG_01699 0.0 V ABC transporter (Permease
HEPMHJLG_01701 2.4e-228 V ABC transporter (Permease
HEPMHJLG_01702 6e-129 V ABC transporter, ATP-binding protein
HEPMHJLG_01703 0.0 mutS2 L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
HEPMHJLG_01704 4.1e-90 cvpA S toxin biosynthetic process
HEPMHJLG_01705 9.3e-15 zapA D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HEPMHJLG_01706 1.3e-154 rnhC 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HEPMHJLG_01707 1.5e-115 lepB 3.4.21.89 U Belongs to the peptidase S26 family
HEPMHJLG_01708 0.0 recD2 3.1.11.5 L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
HEPMHJLG_01709 3.7e-46 azlD S branched-chain amino acid
HEPMHJLG_01710 3.9e-114 azlC E AzlC protein
HEPMHJLG_01711 1.3e-185 tsaD 2.3.1.234 O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HEPMHJLG_01712 9e-72 rimI 2.3.1.128 K This enzyme acetylates the N-terminal alanine of ribosomal protein S18
HEPMHJLG_01713 3.9e-114 yeaZ 2.3.1.234 O COG1214, inactive homolog of metal-dependent proteases
HEPMHJLG_01714 1.5e-33 ykzG S Belongs to the UPF0356 family
HEPMHJLG_01715 0.0 rnjA S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HEPMHJLG_01716 6.6e-116 pscB M CHAP domain protein
HEPMHJLG_01717 5.2e-264 glnA 6.3.1.2 E glutamine synthetase
HEPMHJLG_01718 2.5e-62 glnR K Transcriptional regulator
HEPMHJLG_01719 3e-87 S Fusaric acid resistance protein-like
HEPMHJLG_01720 5.8e-222 pgk 2.7.2.3, 5.3.1.1 F Belongs to the phosphoglycerate kinase family
HEPMHJLG_01721 7.1e-14
HEPMHJLG_01722 7.9e-188 gap 1.2.1.12 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
HEPMHJLG_01723 0.0 fusA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HEPMHJLG_01724 3.9e-81 rpsG J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
HEPMHJLG_01725 2.3e-69 rpsL J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HEPMHJLG_01726 4e-142 purR 2.4.2.7 F operon repressor
HEPMHJLG_01727 3.1e-178 cbf S 3'-5' exoribonuclease yhaM
HEPMHJLG_01728 1.6e-169 rmuC S RmuC domain protein
HEPMHJLG_01729 1.6e-117 thiN 2.7.6.2 H thiamine pyrophosphokinase
HEPMHJLG_01730 2.3e-119 rpe 5.1.3.1 G Belongs to the ribulose-phosphate 3-epimerase family
HEPMHJLG_01731 6.4e-162 rsgA 3.1.3.100 G One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
HEPMHJLG_01733 2.9e-154 ksgA 2.1.1.182 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
HEPMHJLG_01734 1.1e-98 rnmV 3.1.26.8 J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HEPMHJLG_01735 1.1e-144 tatD L Hydrolase, tatd
HEPMHJLG_01736 2.5e-74 yccU S CoA-binding protein
HEPMHJLG_01737 6.3e-51 trxA O Belongs to the thioredoxin family
HEPMHJLG_01738 1.3e-142 S Macro domain protein
HEPMHJLG_01739 8.2e-59 L thioesterase
HEPMHJLG_01740 5.9e-55 bta 1.8.1.8 CO cell redox homeostasis
HEPMHJLG_01742 0.0 M family 8
HEPMHJLG_01743 4e-113 cutC P Participates in the control of copper homeostasis
HEPMHJLG_01744 1.4e-129 S CAAX amino terminal protease family
HEPMHJLG_01745 6.3e-94 ypgQ F HD superfamily hydrolase
HEPMHJLG_01746 2e-95 XK27_08140 K Bacterial regulatory proteins, tetR family
HEPMHJLG_01747 7.1e-150 yitS S EDD domain protein, DegV family
HEPMHJLG_01748 1e-199 yeaN P transporter
HEPMHJLG_01749 4.7e-138 L Transposase and inactivated derivatives
HEPMHJLG_01750 5.3e-74 L Transposase
HEPMHJLG_01751 3e-75 XK27_04435 3.5.4.5 J Acetyltransferase GNAT family
HEPMHJLG_01752 5.9e-40 S hydrolases or acyltransferases (alpha beta hydrolase superfamily)
HEPMHJLG_01753 2e-158 K DNA-binding helix-turn-helix protein
HEPMHJLG_01754 1.2e-138 S CAAX protease self-immunity
HEPMHJLG_01755 4.3e-138 S Alpha beta hydrolase
HEPMHJLG_01756 2.7e-64
HEPMHJLG_01757 5e-54 D Plasmid stabilization system
HEPMHJLG_01758 2.2e-45
HEPMHJLG_01759 1.8e-147 S hydrolases or acyltransferases (alpha beta hydrolase superfamily)
HEPMHJLG_01760 2e-58 S ParE toxin of type II toxin-antitoxin system, parDE
HEPMHJLG_01761 4.8e-45
HEPMHJLG_01762 0.0 O Molecular chaperone. Has ATPase activity
HEPMHJLG_01763 1.8e-256 rumA 2.1.1.190 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HEPMHJLG_01764 2e-97 mip S hydroperoxide reductase activity
HEPMHJLG_01765 2.2e-201 I acyl-CoA dehydrogenase
HEPMHJLG_01766 1.7e-152 ydiA P C4-dicarboxylate transporter malic acid transport
HEPMHJLG_01767 1.7e-244 msrR K Transcriptional regulator
HEPMHJLG_01768 2.5e-152 pheA 4.2.1.51 E Prephenate dehydratase
HEPMHJLG_01769 6.7e-76 aroK 1.1.1.25, 2.7.1.71, 4.2.1.10, 4.2.3.4 F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HEPMHJLG_01770 3.7e-235 aroA 1.3.1.12, 1.3.1.43, 2.5.1.19 E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
HEPMHJLG_01771 2.4e-170 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
HEPMHJLG_01772 4.2e-53 yheA S Belongs to the UPF0342 family
HEPMHJLG_01773 8.3e-207 tyrA 1.3.1.12, 1.3.1.43 E prephenate dehydrogenase
HEPMHJLG_01774 9.9e-219 aroC 4.2.3.5 E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HEPMHJLG_01775 5.9e-202 aroB 2.7.1.71, 4.2.3.4 E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HEPMHJLG_01776 3.5e-160 aroE 1.1.1.25 E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HEPMHJLG_01777 2.1e-120 aroD 1.1.1.25, 4.2.1.10 E Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
HEPMHJLG_01778 1.4e-217 ywbD 2.1.1.191 J Methyltransferase
HEPMHJLG_01779 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
HEPMHJLG_01780 4.6e-25 WQ51_00785
HEPMHJLG_01781 7.4e-247 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
HEPMHJLG_01782 3.4e-74 yueI S Protein of unknown function (DUF1694)
HEPMHJLG_01783 4e-193 glxK 2.7.1.165 G Belongs to the glycerate kinase type-1 family
HEPMHJLG_01784 6.6e-193 yyaQ S YjbR
HEPMHJLG_01785 4.1e-181 ccpA K Catabolite control protein A
HEPMHJLG_01786 1.4e-195 pepQ 3.4.13.9 E Belongs to the peptidase M24B family
HEPMHJLG_01787 1.3e-63 yugI 5.3.1.9 J RNA binding protein, contains ribosomal protein S1 domain
HEPMHJLG_01788 2e-274 ppiB 5.2.1.8 G PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HEPMHJLG_01789 6.6e-81 smpB O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
HEPMHJLG_01790 0.0 rnr J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
HEPMHJLG_01791 2e-33 secG U Preprotein translocase subunit SecG
HEPMHJLG_01792 2.2e-221 mdtG EGP Major facilitator Superfamily
HEPMHJLG_01793 5.1e-102 coaE 2.7.1.24, 3.2.2.23, 4.2.99.18 GH23 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HEPMHJLG_01794 6.9e-150 fpg 3.2.2.23, 4.2.99.18 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
HEPMHJLG_01795 2.2e-165 era M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HEPMHJLG_01796 2e-65 dgkA 2.7.1.107, 2.7.1.66 M Diacylglycerol kinase
HEPMHJLG_01797 4.6e-88 ybeY 2.6.99.2, 3.5.4.5 S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HEPMHJLG_01798 4.6e-149 licT K antiterminator
HEPMHJLG_01799 1.3e-105 recR L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HEPMHJLG_01800 0.0 pbp2b 3.4.16.4 M penicillin-binding protein
HEPMHJLG_01801 1.1e-145 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HEPMHJLG_01802 4.3e-155 folD 1.5.1.5, 3.5.4.9 F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HEPMHJLG_01803 2.9e-150 I Alpha/beta hydrolase family
HEPMHJLG_01804 6.6e-08
HEPMHJLG_01805 0.0 feoB P transporter of a GTP-driven Fe(2 ) uptake system
HEPMHJLG_01806 1.4e-78 feoA P FeoA domain protein
HEPMHJLG_01807 6.4e-131 glnQ 3.6.3.21 E abc transporter atp-binding protein
HEPMHJLG_01808 5.8e-118 WQ51_01820 P Binding-protein-dependent transport system inner membrane component
HEPMHJLG_01809 1e-34 ykuJ S protein conserved in bacteria
HEPMHJLG_01810 1.4e-181 argF 2.1.3.3 E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HEPMHJLG_01811 0.0 clpE O Belongs to the ClpA ClpB family
HEPMHJLG_01812 1.2e-82 mutT 3.5.4.33, 3.6.1.13, 3.6.1.55 L Belongs to the Nudix hydrolase family
HEPMHJLG_01813 6.2e-48 XK27_09445 S Domain of unknown function (DUF1827)
HEPMHJLG_01814 1.3e-171 S oxidoreductase
HEPMHJLG_01815 9.3e-81 M Pfam SNARE associated Golgi protein
HEPMHJLG_01816 2.6e-135 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
HEPMHJLG_01817 0.0 tkt 2.2.1.1 G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HEPMHJLG_01819 2.8e-111 tmk 2.7.4.9 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HEPMHJLG_01820 9.6e-158 holB 2.7.7.7 L dna polymerase iii
HEPMHJLG_01821 8.9e-134 yaaT S stage 0 sporulation protein
HEPMHJLG_01822 1.2e-54 yabA L Involved in initiation control of chromosome replication
HEPMHJLG_01823 4e-156 rsmI 2.1.1.198 H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HEPMHJLG_01824 1.9e-228 amt P Ammonium Transporter
HEPMHJLG_01825 1.9e-53 glnB K Belongs to the P(II) protein family
HEPMHJLG_01826 1.6e-104 mur1 3.4.17.14, 3.5.1.28 NU amidase activity
HEPMHJLG_01827 1.7e-108 S HD domain
HEPMHJLG_01828 7e-147 XK27_04800 S Sucrose-6F-phosphate phosphohydrolase
HEPMHJLG_01829 5.6e-84 S Bacterial inner membrane protein
HEPMHJLG_01830 3.7e-111 3.4.17.14, 3.5.1.28 NU amidase activity
HEPMHJLG_01831 7.2e-292 nptA P COG1283 Na phosphate symporter
HEPMHJLG_01832 2.6e-211 nagA 3.5.1.25 G Belongs to the metallo-dependent hydrolases superfamily. NagA family
HEPMHJLG_01833 5.6e-220 S membrane
HEPMHJLG_01834 3.7e-176 glyQ 6.1.1.14 J glycyl-tRNA synthetase alpha subunit
HEPMHJLG_01835 0.0 glyS 6.1.1.14 J Glycyl-tRNA synthetase beta subunit
HEPMHJLG_01836 2e-39 ynzC S UPF0291 protein
HEPMHJLG_01837 1.2e-255 cycA E permease
HEPMHJLG_01838 6e-08 uvrX 2.7.7.7 L impB/mucB/samB family
HEPMHJLG_01839 0.0 pts33BCA 2.7.1.201, 2.7.1.208, 2.7.1.211 G pts system
HEPMHJLG_01840 9.2e-141 ppiA 5.2.1.8 O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HEPMHJLG_01843 3.4e-69 K Helix-turn-helix
HEPMHJLG_01845 4.7e-168 fhuR K transcriptional regulator (lysR family)
HEPMHJLG_01846 4.8e-76 lspA 3.4.23.36 MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HEPMHJLG_01847 1.1e-161 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
HEPMHJLG_01848 4.8e-88 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HEPMHJLG_01849 3.6e-222 pyrP F uracil Permease
HEPMHJLG_01850 1.3e-173 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
HEPMHJLG_01851 9.3e-211 carA 6.3.5.5 F carbamoyl-phosphate synthetase glutamine chain
HEPMHJLG_01852 0.0 carB 6.3.5.5 F carbamoyl-phosphate synthetase ammonia chain
HEPMHJLG_01853 2.3e-128 2.1.1.223 S Putative SAM-dependent methyltransferase
HEPMHJLG_01854 3.6e-182 acrA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEPMHJLG_01855 2.9e-120 macB V ABC transporter, ATP-binding protein
HEPMHJLG_01856 1.2e-211 V permease protein
HEPMHJLG_01857 1.9e-78 rplJ J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HEPMHJLG_01858 2.1e-45 rplL J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
HEPMHJLG_01860 2.5e-273 opuD M Belongs to the BCCT transporter (TC 2.A.15) family
HEPMHJLG_01861 0.0 mdlB V abc transporter atp-binding protein
HEPMHJLG_01862 0.0 lmrA V abc transporter atp-binding protein
HEPMHJLG_01863 2.1e-199 queA 2.4.99.17 J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HEPMHJLG_01864 2e-121 nagB 3.1.1.31, 3.5.99.6 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
HEPMHJLG_01865 5.3e-213 2.7.13.3 T signal transduction protein with a C-terminal ATPase domain
HEPMHJLG_01866 1.2e-129 rr02 KT response regulator
HEPMHJLG_01867 5.7e-219 2.7.7.73, 2.7.7.80 H Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
HEPMHJLG_01868 9.3e-164 V ABC transporter
HEPMHJLG_01869 3.3e-119 sagI S ABC-2 type transporter
HEPMHJLG_01870 7.6e-196 yceA S Belongs to the UPF0176 family
HEPMHJLG_01871 2.3e-27 XK27_00085 K Transcriptional
HEPMHJLG_01872 2.1e-24
HEPMHJLG_01873 4.2e-133 deoD_1 2.4.2.3 F Phosphorylase superfamily
HEPMHJLG_01874 3.9e-114 S VIT family
HEPMHJLG_01875 7.2e-127 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
HEPMHJLG_01876 7e-217 hipO 3.5.1.47 E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
HEPMHJLG_01877 2.2e-199 ald 1.4.1.1 C Belongs to the AlaDH PNT family
HEPMHJLG_01880 4.9e-140 E Alpha beta hydrolase
HEPMHJLG_01881 5.2e-248 merA 1.16.1.1 C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEPMHJLG_01882 0.0 2.4.1.5 GH13 M KxYKxGKxW signal domain protein
HEPMHJLG_01883 1.9e-227 rodA D Belongs to the SEDS family
HEPMHJLG_01884 7.1e-223 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HEPMHJLG_01885 1.2e-112 galT 2.7.7.12 G UDPglucose--hexose-1-phosphate uridylyltransferase
HEPMHJLG_01886 2.7e-174 rnz 3.1.26.11 S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
HEPMHJLG_01887 9.7e-138 XK27_05435 1.1.1.100 S Belongs to the short-chain dehydrogenases reductases (SDR) family
HEPMHJLG_01888 5.2e-66 GnaT 2.5.1.16 K acetyltransferase
HEPMHJLG_01889 0.0 recJ L Single-strand DNA-specific exonuclease, C terminal domain
HEPMHJLG_01890 1.7e-93 apt 2.4.2.7 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HEPMHJLG_01891 4.6e-182 metA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HEPMHJLG_01892 1.1e-124 dnaD
HEPMHJLG_01893 2.9e-119 nth 4.2.99.18 L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HEPMHJLG_01894 1.8e-06 KT response to antibiotic
HEPMHJLG_01895 3.3e-234 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HEPMHJLG_01896 4.6e-29 xseB 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HEPMHJLG_01897 2.2e-154 ispA 2.5.1.1, 2.5.1.10, 2.5.1.29, 2.5.1.90 H Belongs to the FPP GGPP synthase family
HEPMHJLG_01898 2.2e-148 rrmJ 2.1.1.226, 2.1.1.227 J Ribosomal RNA large subunit methyltransferase J
HEPMHJLG_01899 2.8e-73 argR K Regulates arginine biosynthesis genes
HEPMHJLG_01900 1e-301 recN L May be involved in recombinational repair of damaged DNA
HEPMHJLG_01901 9.3e-150 DegV S DegV family
HEPMHJLG_01902 2.2e-162 ypmR E COG2755 Lysophospholipase L1 and related esterases
HEPMHJLG_01903 6.2e-97 ypmS S Protein conserved in bacteria
HEPMHJLG_01904 6.3e-39 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
HEPMHJLG_01906 6.2e-179 pyrD 1.3.1.14, 1.3.98.1 F Catalyzes the conversion of dihydroorotate to orotate
HEPMHJLG_01907 4.6e-131 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HEPMHJLG_01908 4.9e-290 leuA 2.3.3.13 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEPMHJLG_01909 6.6e-190 leuB 1.1.1.85 CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
HEPMHJLG_01910 3.5e-37 ysdA L Membrane
HEPMHJLG_01911 2.1e-276 leuC 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HEPMHJLG_01912 2.4e-112 leuD 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HEPMHJLG_01913 0.0 dnaE 2.7.7.7 L DNA polymerase
HEPMHJLG_01914 3.6e-188 pfkA 2.7.1.11 F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
HEPMHJLG_01915 6e-277 pyk 2.7.1.40, 2.7.7.4 G Belongs to the pyruvate kinase family
HEPMHJLG_01916 4.8e-31 L COG1943 Transposase and inactivated derivatives
HEPMHJLG_01917 2.9e-18 S Domain of unknown function (DUF4649)
HEPMHJLG_01918 1.4e-176 XK27_08835 S ABC transporter substrate binding protein
HEPMHJLG_01919 2.6e-147 XK27_08840 S Belongs to the binding-protein-dependent transport system permease family
HEPMHJLG_01920 3.1e-136 XK27_08845 S abc transporter atp-binding protein
HEPMHJLG_01921 7.8e-310 rnjB S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HEPMHJLG_01922 1.8e-147 estA CE1 S Esterase
HEPMHJLG_01923 1.6e-126 XK27_08875 O Zinc-dependent metalloprotease
HEPMHJLG_01924 1.1e-17 XK27_08880
HEPMHJLG_01925 1e-75 fld C Flavodoxin
HEPMHJLG_01926 3.6e-277 clcA P Chloride transporter, ClC family
HEPMHJLG_01927 4.7e-37 pheA 1.3.1.12, 2.3.1.79, 4.2.1.51, 5.4.99.5 E Chorismate mutase
HEPMHJLG_01928 1e-213 XK27_05110 P Chloride transporter ClC family
HEPMHJLG_01929 1.1e-56 rplS J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
HEPMHJLG_01932 3.2e-20 WQ51_02665 S Protein of unknown function (DUF3042)
HEPMHJLG_01933 4.6e-163 miaA 2.5.1.75 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HEPMHJLG_01934 3.3e-86 ytsP 1.8.4.14 T GAF domain-containing protein
HEPMHJLG_01935 4.6e-302 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HEPMHJLG_01936 4.8e-171 birA 6.3.4.15 HK Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
HEPMHJLG_01937 1.2e-211 metK 2.5.1.6 H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme

eggNOG-mapper v2 (Database: eggNOG v5.0, Jul. 2018 release)