ORF_ID e_value Gene_name EC_number CAZy COGs Description
NHFKFMEO_00001 1e-193 amt P Ammonium transporter
NHFKFMEO_00002 1.6e-58 nrgB K Belongs to the P(II) protein family
NHFKFMEO_00003 3.4e-103 bcrC 3.6.1.27 I COG0671 Membrane-associated phospholipid phosphatase
NHFKFMEO_00004 3e-72 ywnJ S VanZ like family
NHFKFMEO_00005 5.3e-116 spoIIQ M COG0739 Membrane proteins related to metalloendopeptidases
NHFKFMEO_00006 4.1e-89 ywnH 2.3.1.183 M COG1247 Sortase and related acyltransferases
NHFKFMEO_00007 8.9e-10 ywnC S Family of unknown function (DUF5362)
NHFKFMEO_00008 2.2e-70 ywnF S Family of unknown function (DUF5392)
NHFKFMEO_00009 1.2e-277 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NHFKFMEO_00010 5e-142 mta K transcriptional
NHFKFMEO_00011 2.6e-59 ywnC S Family of unknown function (DUF5362)
NHFKFMEO_00012 3.1e-113 ywnB S NAD(P)H-binding
NHFKFMEO_00013 1.7e-64 ywnA K Transcriptional regulator
NHFKFMEO_00014 0.0 ureC 3.5.1.5 E Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family
NHFKFMEO_00015 1.7e-63 ureB 3.5.1.5 E Belongs to the urease beta subunit family
NHFKFMEO_00016 6.3e-51 ureA 3.5.1.5 E Belongs to the urease gamma subunit family
NHFKFMEO_00017 2.8e-08 urtE E COG0410 ABC-type branched-chain amino acid transport systems, ATPase component
NHFKFMEO_00018 3.8e-11 csbD K CsbD-like
NHFKFMEO_00019 3e-84 ywmF S Peptidase M50
NHFKFMEO_00020 2.3e-103 S response regulator aspartate phosphatase
NHFKFMEO_00021 2e-191 moaA 4.1.99.22, 4.6.1.17 H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NHFKFMEO_00022 9.9e-146 fdhD C Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NHFKFMEO_00024 7.2e-121 ywmD S protein containing a von Willebrand factor type A (vWA) domain
NHFKFMEO_00025 1.7e-122 ywmC S protein containing a von Willebrand factor type A (vWA) domain
NHFKFMEO_00026 9.2e-176 spoIID D Stage II sporulation protein D
NHFKFMEO_00027 3.9e-240 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NHFKFMEO_00028 1.9e-130 ywmB S TATA-box binding
NHFKFMEO_00029 2.1e-32 ywzB S membrane
NHFKFMEO_00030 1.1e-86 ywmA
NHFKFMEO_00031 9.4e-52 atpC C Produces ATP from ADP in the presence of a proton gradient across the membrane
NHFKFMEO_00032 1.2e-266 atpD 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NHFKFMEO_00033 1.1e-150 atpG C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NHFKFMEO_00034 4.5e-280 atpA 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NHFKFMEO_00035 1.6e-89 atpH C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NHFKFMEO_00036 3.8e-45 atpF C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NHFKFMEO_00037 1.6e-26 atpE C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NHFKFMEO_00038 4.6e-129 atpB C it plays a direct role in the translocation of protons across the membrane
NHFKFMEO_00039 2.5e-62 atpI S ATP synthase
NHFKFMEO_00040 4.7e-114 upp 2.4.2.9 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NHFKFMEO_00041 2.1e-238 glyA 2.1.2.1 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NHFKFMEO_00042 3.6e-94 ywlG S Belongs to the UPF0340 family
NHFKFMEO_00043 8.3e-81 rpiB 5.3.1.6 G Ribose 5-phosphate isomerase
NHFKFMEO_00044 3.6e-76 ywlE 3.1.3.48, 3.9.1.2, 5.3.1.6 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NHFKFMEO_00045 3.8e-91 mntP P Probably functions as a manganese efflux pump
NHFKFMEO_00046 8.1e-196 ywlC 2.7.7.87, 3.1.3.48 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
NHFKFMEO_00047 1.2e-76 ywlB 1.20.4.1, 2.3.1.1 E Belongs to the acetyltransferase family. ArgA subfamily
NHFKFMEO_00048 6.1e-112 spoIIR S stage II sporulation protein R
NHFKFMEO_00049 9.8e-56 ywlA S Uncharacterised protein family (UPF0715)
NHFKFMEO_00051 6.2e-157 prmC 2.1.1.297 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
NHFKFMEO_00052 9.5e-192 prfA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NHFKFMEO_00053 8.2e-69 yaeR E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
NHFKFMEO_00054 7.1e-90 racA K Required for the formation of axial filaments and for anchoring the origin regions at the cell poles in sporulating cells, thus ensuring proper chromosome segregation in the prespore. Binds in a dispersed manner throughout the chromosome but preferentially to sites clustered in the origin portion of the chromosome, causing condensation of the chromosome and its remodeling into an elongated, anchored structure
NHFKFMEO_00055 8.6e-160 ywkB S Membrane transport protein
NHFKFMEO_00056 0.0 sfcA 1.1.1.38 C malic enzyme
NHFKFMEO_00057 5.4e-104 tdk 2.7.1.21 F thymidine kinase
NHFKFMEO_00058 1.1e-32 rpmE J Binds the 23S rRNA
NHFKFMEO_00059 2.8e-238 rho K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NHFKFMEO_00060 5.6e-175 glpX 3.1.3.11, 3.1.3.37 G fructose-1,6-bisphosphatase
NHFKFMEO_00061 8.6e-240 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NHFKFMEO_00062 1.5e-112 tal 2.2.1.2 G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NHFKFMEO_00063 7.2e-158 fbaA 4.1.2.13, 4.1.2.29 G Aldolase
NHFKFMEO_00064 1.1e-62 spo0F T COG0784 FOG CheY-like receiver
NHFKFMEO_00065 5.1e-90 ywjG S Domain of unknown function (DUF2529)
NHFKFMEO_00066 0.0 pyrG 6.3.4.2 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
NHFKFMEO_00067 4.8e-48 rpoE K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
NHFKFMEO_00068 1.3e-210 acdA 1.3.8.1, 1.3.8.7 I acyl-CoA dehydrogenase
NHFKFMEO_00069 0.0 fadF C COG0247 Fe-S oxidoreductase
NHFKFMEO_00070 1.5e-222 clsB I Belongs to the phospholipase D family. Cardiolipin synthase subfamily
NHFKFMEO_00071 3.3e-183 uvsE L Component in a DNA repair pathway. Removal of UV-light damaged nucleotides. Recognizes pyrimidine dimers and cleave a phosphodiester bond immediately 5' to the lesion
NHFKFMEO_00072 2.7e-42 ywjC
NHFKFMEO_00073 4.8e-96 ywjB H RibD C-terminal domain
NHFKFMEO_00074 0.0 ywjA V ABC transporter
NHFKFMEO_00075 2.4e-286 ywiE I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NHFKFMEO_00076 3.1e-124 narI 1.7.5.1 C nitrate reductase, gamma
NHFKFMEO_00077 1.1e-93 narJ 1.7.5.1 C nitrate reductase
NHFKFMEO_00078 1.5e-296 narH 1.7.5.1 C Nitrate reductase, beta
NHFKFMEO_00079 0.0 narG 1.7.5.1 C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
NHFKFMEO_00080 7e-86 arfM T cyclic nucleotide binding
NHFKFMEO_00081 5.1e-26 ywiC S YwiC-like protein
NHFKFMEO_00082 2.5e-91 ywiC S YwiC-like protein
NHFKFMEO_00083 2e-129 fnr K helix_turn_helix, cAMP Regulatory protein
NHFKFMEO_00084 1.3e-213 narK P COG2223 Nitrate nitrite transporter
NHFKFMEO_00085 0.0 argS 6.1.1.19 J Arginyl-tRNA synthetase
NHFKFMEO_00086 4.7e-73 ywiB S protein conserved in bacteria
NHFKFMEO_00087 1e-07 S Bacteriocin subtilosin A
NHFKFMEO_00088 5.4e-269 C Fe-S oxidoreductases
NHFKFMEO_00089 3.7e-131 cbiO V ABC transporter
NHFKFMEO_00090 1.6e-233 mgtA 3.6.3.2 P ATPase, P-type transporting, HAD superfamily, subfamily IC
NHFKFMEO_00091 1.1e-212 2.7.1.26, 2.7.7.2 L Peptidase, M16
NHFKFMEO_00092 1.3e-248 L Peptidase, M16
NHFKFMEO_00094 1.9e-245 ywhL CO amine dehydrogenase activity
NHFKFMEO_00095 2.1e-191 ywhK CO amine dehydrogenase activity
NHFKFMEO_00096 3.1e-79 S aspartate phosphatase
NHFKFMEO_00098 9.2e-169 speB 3.5.3.11 E Belongs to the arginase family
NHFKFMEO_00099 1.4e-158 speE 2.5.1.16 E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NHFKFMEO_00100 0.0 pbpG 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
NHFKFMEO_00101 3.6e-49
NHFKFMEO_00102 5.2e-95 ywhD S YwhD family
NHFKFMEO_00103 5.1e-119 ywhC S Peptidase family M50
NHFKFMEO_00104 2.7e-25 dmpI 5.3.2.6 G 4-oxalocrotonate tautomerase
NHFKFMEO_00105 9.5e-71 ywhA K Transcriptional regulator
NHFKFMEO_00106 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NHFKFMEO_00108 2.4e-235 mmr U Major Facilitator Superfamily
NHFKFMEO_00109 2.4e-78 yffB K Transcriptional regulator
NHFKFMEO_00110 2.7e-88 ywgA 2.1.1.72, 3.1.21.3
NHFKFMEO_00111 1.1e-255 ywfO S COG1078 HD superfamily phosphohydrolases
NHFKFMEO_00112 3.1e-36 ywzC S Belongs to the UPF0741 family
NHFKFMEO_00113 1e-110 rsfA_1
NHFKFMEO_00114 2.2e-157 ywfM EG EamA-like transporter family
NHFKFMEO_00115 8.7e-156 lipL 2.3.1.200, 2.3.1.204 H Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes
NHFKFMEO_00116 1.1e-156 cysL K Transcriptional regulator
NHFKFMEO_00117 5.6e-175 pta 2.3.1.19, 2.3.1.8, 3.6.3.21 C In Salmonella this enzyme is required for ethanolamine catabolism
NHFKFMEO_00118 1.1e-146 ywfI C May function as heme-dependent peroxidase
NHFKFMEO_00119 1.1e-136 IQ Enoyl-(Acyl carrier protein) reductase
NHFKFMEO_00120 5e-234 ywfG 2.6.1.83 E Aminotransferase class I and II
NHFKFMEO_00121 1.9e-209 bacE EGP Major facilitator Superfamily
NHFKFMEO_00122 3.6e-271 purD 6.3.2.49, 6.3.4.13 F Part of the bacABCDEFG operon responsible for the biosynthesis of bacilysin, an irreversible inactivator of the glutaminase domain of glucosamine synthetase. Catalyzes the formation of alpha-dipeptides from various L-amino acids in the presence of ATP. In vivo catalyzes the ligation of L-alanine and L-anticapsin (epoxycyclohexanonyl-Ala) to produce the final bacilysin antibiotic (L-Ala-L-4S-cyclohexenonyl-Ala dipeptide)
NHFKFMEO_00123 2.5e-138 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
NHFKFMEO_00124 1.3e-136 bacB 5.3.3.19, 5.4.99.5 S Part of the bacABCDEF operon responsible for the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase. BacB catalyzes the allylic isomerization of the
NHFKFMEO_00125 8.6e-113 pheA 1.1.1.3, 1.3.1.12, 4.1.1.100, 4.2.1.51, 5.4.99.5 E Part of the bacABCDEF operon responsible for the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase. BacA is an unusual prephenate decarboxylase that avoids the typical aromatization of the cyclohexadienol ring of prephenate. BacA catalyzes the protonation of prephenate (1-carboxy-4-hydroxy-alpha-oxo-2,5-cyclohexadiene-1- propanoic acid) at C6 position, followed by a decarboxylation to produce the endocyclic-delta(4),delta(8)-7R-dihydro- hydroxyphenylpyruvate (en-H2HPP). En-H2HPP is able to undergo a slow nonenzymatic isomerization to produce the exocyclic- delta(3),delta(5)-dihydro-hydroxyphenylpyruvate (ex-H2HPP). BacA isomerizes only the pro-R double bond in prephenate
NHFKFMEO_00126 6e-206 ywfA EGP Major facilitator Superfamily
NHFKFMEO_00127 4.8e-249 lysP E amino acid
NHFKFMEO_00128 0.0 rocB E arginine degradation protein
NHFKFMEO_00129 1.6e-296 putA 1.2.1.88, 1.5.5.2 C Belongs to the aldehyde dehydrogenase family. RocA subfamily
NHFKFMEO_00130 8.3e-243 rocG 1.4.1.2, 1.4.1.3 E Belongs to the Glu Leu Phe Val dehydrogenases family
NHFKFMEO_00131 3.4e-77
NHFKFMEO_00132 1.3e-86 spsL 5.1.3.13 M Spore Coat
NHFKFMEO_00133 2.2e-159 spsK 1.1.1.133 M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
NHFKFMEO_00134 1e-181 rfbB 4.2.1.46 M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
NHFKFMEO_00135 3.2e-138 spsI 2.7.7.24 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NHFKFMEO_00136 1.5e-183 spsG M Spore Coat
NHFKFMEO_00137 1e-128 spsF M Spore Coat
NHFKFMEO_00138 6e-213 spsE 2.5.1.56 M acid synthase
NHFKFMEO_00139 1.7e-162 spsD 2.3.1.210 K Spore Coat
NHFKFMEO_00140 1.1e-222 spsC E Belongs to the DegT DnrJ EryC1 family
NHFKFMEO_00141 4.7e-268 spsB M Capsule polysaccharide biosynthesis protein
NHFKFMEO_00142 4.5e-143 spsA M Spore Coat
NHFKFMEO_00143 4.8e-75 gerQ S Essential for the localization of CwlJ in the spore coat and for spore germination triggered by calcium and dipicolinic acid (DPA). Its assembly into the spore coat is dependent on the coat morphogenetic proteins CotE and SpoIVA
NHFKFMEO_00144 4.3e-59 ywdK S small membrane protein
NHFKFMEO_00145 8.3e-238 ywdJ F Xanthine uracil
NHFKFMEO_00146 6.6e-48 ywdI S Family of unknown function (DUF5327)
NHFKFMEO_00147 1e-259 ywdH 1.2.1.3 C Belongs to the aldehyde dehydrogenase family
NHFKFMEO_00148 1.1e-129 ung 3.2.2.27 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NHFKFMEO_00149 1.6e-151 ywdF GT2,GT4 S Glycosyltransferase like family 2
NHFKFMEO_00150 3.5e-146 thiD 2.5.1.3, 2.7.1.35, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Phosphomethylpyrimidine kinase
NHFKFMEO_00151 2e-28 ywdA
NHFKFMEO_00152 3e-289 scrB 3.2.1.26, 3.2.1.65, 3.2.1.80 GH32 G invertase
NHFKFMEO_00153 2.1e-252 scrA 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
NHFKFMEO_00154 5.7e-138 focA P Formate/nitrite transporter
NHFKFMEO_00155 7e-150 sacT K transcriptional antiterminator
NHFKFMEO_00157 0.0 vpr O Belongs to the peptidase S8 family
NHFKFMEO_00158 3.3e-186 ywcH C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NHFKFMEO_00159 6.1e-137 nfrA 1.5.1.38, 1.5.1.39 C Oxidoreductase
NHFKFMEO_00160 8.6e-202 rodA D Belongs to the SEDS family
NHFKFMEO_00161 6e-39 ywcE S Required for proper spore morphogenesis. Important for spore germination
NHFKFMEO_00162 2.6e-64 qoxD 1.10.3.12, 1.9.3.1 C quinol oxidase, subunit
NHFKFMEO_00163 1.2e-111 qoxC 1.10.3.12, 1.9.3.1 C quinol oxidase, subunit
NHFKFMEO_00164 0.0 qoxB 1.10.3.12, 1.9.3.1 C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NHFKFMEO_00165 2.1e-177 cyoA 1.10.3.10, 1.10.3.12 C Catalyzes quinol oxidation with the concomitant reduction of oxygen to water. Subunit II transfers the electrons from a quinol to the binuclear center of the catalytic subunit I
NHFKFMEO_00166 1e-35 ywzA S membrane
NHFKFMEO_00167 1.8e-300 galT 2.7.7.12 G UDP-glucose--hexose-1-phosphate uridylyltransferase
NHFKFMEO_00168 3.1e-228 galK 2.7.1.6 G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NHFKFMEO_00169 1.6e-59 gtcA S GtrA-like protein
NHFKFMEO_00170 1.1e-121 ywcC K transcriptional regulator
NHFKFMEO_00172 9.8e-49 ywcB S Protein of unknown function, DUF485
NHFKFMEO_00173 6.9e-268 ywcA S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NHFKFMEO_00174 4e-110 ywbO Q dithiol-disulfide isomerase involved in polyketide biosynthesis
NHFKFMEO_00175 3.2e-223 ywbN P Dyp-type peroxidase family protein
NHFKFMEO_00176 2e-163 ycdO P periplasmic lipoprotein involved in iron transport
NHFKFMEO_00177 9e-254 P COG0672 High-affinity Fe2 Pb2 permease
NHFKFMEO_00178 4.5e-115 thiE 2.5.1.3, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
NHFKFMEO_00179 1.4e-142 thiM 2.7.1.50 H Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
NHFKFMEO_00180 4.3e-153 ywbI K Transcriptional regulator
NHFKFMEO_00181 6.5e-58 ywbH S Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein. When a cell is stressed by the addition of antibiotics or by other factors in the environment, CidA possibly oligomerizes within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are also hypothesized to regulate the subsequent cell lysis by either allowing the murein hydrolases access to the cell wall substrate and or regulating their activity by a
NHFKFMEO_00182 2.3e-111 ywbG M effector of murein hydrolase
NHFKFMEO_00183 8.1e-208 ywbF EGP Major facilitator Superfamily
NHFKFMEO_00184 1.4e-27 ywbE S Uncharacterized conserved protein (DUF2196)
NHFKFMEO_00185 3.5e-219 ywbD 2.1.1.191 J Methyltransferase
NHFKFMEO_00186 9.9e-67 ywbC 4.4.1.5 E glyoxalase
NHFKFMEO_00187 6.9e-96 G Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
NHFKFMEO_00188 2.8e-120 ywbB S Protein of unknown function (DUF2711)
NHFKFMEO_00189 4.6e-244 celB G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
NHFKFMEO_00190 2.9e-271 epr 3.4.21.62 O Belongs to the peptidase S8 family
NHFKFMEO_00191 2.9e-241 scrA 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
NHFKFMEO_00192 7.6e-152 sacY K transcriptional antiterminator
NHFKFMEO_00193 2.9e-167 gspA M General stress
NHFKFMEO_00194 3.7e-123 ywaF S Integral membrane protein
NHFKFMEO_00195 2e-86 ywaE K Transcriptional regulator
NHFKFMEO_00196 1.4e-231 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NHFKFMEO_00197 2.6e-250 ywaD 3.4.11.10, 3.4.11.6 S PA domain
NHFKFMEO_00198 2e-91 K Helix-turn-helix XRE-family like proteins
NHFKFMEO_00199 3.2e-49 4.1.1.44 S Carboxymuconolactone decarboxylase family
NHFKFMEO_00200 8.8e-130 ynfM EGP Major facilitator Superfamily
NHFKFMEO_00201 5e-116 ywaC 2.7.6.5 S protein conserved in bacteria
NHFKFMEO_00202 2.3e-165 menA 2.5.1.74 H Belongs to the MenA family. Type 1 subfamily
NHFKFMEO_00203 5e-14 S D-Ala-teichoic acid biosynthesis protein
NHFKFMEO_00204 5.7e-291 dltA 6.1.1.13 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
NHFKFMEO_00205 3.6e-232 dltB M membrane protein involved in D-alanine export
NHFKFMEO_00206 1.5e-36 dltC 6.1.1.13 IQ Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
NHFKFMEO_00207 2.3e-231 dltD M COG3966 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
NHFKFMEO_00208 1.4e-136 dltE M Belongs to the short-chain dehydrogenases reductases (SDR) family
NHFKFMEO_00209 3.1e-206 ilvE 2.6.1.42 E Branched-chain amino acid aminotransferase
NHFKFMEO_00210 1.1e-253 licH 3.2.1.86 GT4 G COG1486 Alpha-galactosidases 6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases
NHFKFMEO_00211 6.7e-38 licA 2.7.1.196, 2.7.1.205 G phosphotransferase system
NHFKFMEO_00212 7e-248 licC G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
NHFKFMEO_00213 2.3e-50 licB 2.7.1.196, 2.7.1.205 G transporter subunit IIB
NHFKFMEO_00214 0.0 licR 2.7.1.202 GKT Mga helix-turn-helix domain
NHFKFMEO_00215 1.1e-19 yxzF
NHFKFMEO_00216 1e-110 mpg 3.2.2.21 L Belongs to the DNA glycosylase MPG family
NHFKFMEO_00217 0.0 katX 1.11.1.6 P serves to protect cells from the toxic effects of hydrogen peroxide
NHFKFMEO_00218 5.4e-212 yxlH EGP Major facilitator Superfamily
NHFKFMEO_00219 4.4e-138 yxlG S COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
NHFKFMEO_00220 4.1e-164 yxlF V ABC transporter, ATP-binding protein
NHFKFMEO_00221 7.6e-28 yxlE S Phospholipase_D-nuclease N-terminal
NHFKFMEO_00222 1.2e-31
NHFKFMEO_00223 3.3e-47 yxlC S Family of unknown function (DUF5345)
NHFKFMEO_00224 1.1e-84 sigY K Belongs to the sigma-70 factor family. ECF subfamily
NHFKFMEO_00225 2.3e-254 yxlA F Belongs to the purine-cytosine permease (2.A.39) family
NHFKFMEO_00226 1.2e-157 nnrD 4.2.1.136, 5.1.99.6 G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NHFKFMEO_00227 0.0 cydD V ATP-binding protein
NHFKFMEO_00228 2.4e-311 cydD V ATP-binding
NHFKFMEO_00229 2.9e-190 cydB 1.10.3.14 C Cytochrome d ubiquinol oxidase, subunit II
NHFKFMEO_00230 1.3e-268 cydA 1.10.3.14 C oxidase, subunit
NHFKFMEO_00231 4.2e-229 cimH C COG3493 Na citrate symporter
NHFKFMEO_00232 7.4e-308 3.4.24.84 O Peptidase family M48
NHFKFMEO_00234 4.7e-154 yxkH G Polysaccharide deacetylase
NHFKFMEO_00237 8.8e-08 P transporter
NHFKFMEO_00238 5.9e-205 msmK P Belongs to the ABC transporter superfamily
NHFKFMEO_00239 7.7e-163 lrp QT PucR C-terminal helix-turn-helix domain
NHFKFMEO_00240 3.6e-274 aldY 1.2.1.3 C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
NHFKFMEO_00241 1.9e-147 yxkD S Uncharacterised 5xTM membrane BCR, YitT family COG1284
NHFKFMEO_00242 1.3e-74 yxkC S Domain of unknown function (DUF4352)
NHFKFMEO_00243 4.6e-196 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
NHFKFMEO_00244 3.4e-77 S Protein of unknown function (DUF1453)
NHFKFMEO_00245 2.5e-188 yxjM T Signal transduction histidine kinase
NHFKFMEO_00246 7.8e-112 K helix_turn_helix, Lux Regulon
NHFKFMEO_00247 1.8e-234 pepT 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
NHFKFMEO_00250 6.7e-84 yxjI S LURP-one-related
NHFKFMEO_00251 5.1e-220 yxjG 2.1.1.14 E Methionine synthase
NHFKFMEO_00252 8.2e-218 yxjG 2.1.1.14 E Methionine synthase
NHFKFMEO_00253 3.1e-136 IQ Catalyzes the formation of acetoacetate from 3-hydroxybutyrate
NHFKFMEO_00254 5.2e-116 scoB 2.8.3.5 I COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit
NHFKFMEO_00255 1.8e-130 scoA 2.8.3.5 I COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NHFKFMEO_00256 7.5e-253 yxjC EG COG2610 H gluconate symporter and related permeases
NHFKFMEO_00257 2.7e-157 rlmA 2.1.1.187 Q Methyltransferase domain
NHFKFMEO_00258 1.9e-212 nupG F Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NHFKFMEO_00259 8.8e-103 T Domain of unknown function (DUF4163)
NHFKFMEO_00260 1.9e-46 yxiS
NHFKFMEO_00261 0.0 katE 1.11.1.6, 3.5.1.124 P serves to protect cells from the toxic effects of hydrogen peroxide
NHFKFMEO_00262 6.6e-224 citH C Citrate transporter
NHFKFMEO_00263 3.3e-143 exoK GH16 M licheninase activity
NHFKFMEO_00264 8.3e-151 licT K transcriptional antiterminator
NHFKFMEO_00265 7.6e-110
NHFKFMEO_00266 6.2e-230 yxiO S COG2270 Permeases of the major facilitator superfamily
NHFKFMEO_00267 1.6e-263 dbpA 3.6.4.13 JKL DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes
NHFKFMEO_00268 6.1e-213 3.2.1.14 GH18 E GDSL-like Lipase/Acylhydrolase
NHFKFMEO_00269 7.8e-55 padR K Transcriptional regulator PadR-like family
NHFKFMEO_00270 6.5e-61 S Protein of unknown function (DUF2812)
NHFKFMEO_00273 2.2e-45 yxiJ S YxiJ-like protein
NHFKFMEO_00276 3.4e-34
NHFKFMEO_00277 1e-84 yxiI S Protein of unknown function (DUF2716)
NHFKFMEO_00278 4e-137
NHFKFMEO_00279 9.1e-74 yxiG
NHFKFMEO_00280 4.8e-41
NHFKFMEO_00281 2.1e-163 yxxF EG EamA-like transporter family
NHFKFMEO_00282 4.4e-127 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
NHFKFMEO_00283 5.4e-122 1.14.11.45 E 2OG-Fe dioxygenase
NHFKFMEO_00284 5.4e-72 yxiE T Belongs to the universal stress protein A family
NHFKFMEO_00285 3.9e-278 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
NHFKFMEO_00286 1.5e-309 bglF 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
NHFKFMEO_00287 3.3e-32
NHFKFMEO_00288 2.7e-137 S nuclease activity
NHFKFMEO_00289 1.4e-38 yxiC S Family of unknown function (DUF5344)
NHFKFMEO_00290 2.3e-20 S Domain of unknown function (DUF5082)
NHFKFMEO_00291 2.8e-276 yxiA 3.2.1.99 GH43 G Belongs to the glycosyl hydrolase 43 family
NHFKFMEO_00292 1.1e-77 hutP K Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization
NHFKFMEO_00293 3.4e-283 hutH 4.3.1.3 E Histidine ammonia-lyase
NHFKFMEO_00294 0.0 hutU 4.2.1.49 E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NHFKFMEO_00295 1.4e-234 hutI 3.5.2.7 Q Imidazolone-5-propionate hydrolase
NHFKFMEO_00296 4.4e-180 hutG 3.5.3.11, 3.5.3.8 E Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide
NHFKFMEO_00297 9.8e-250 lysP E amino acid
NHFKFMEO_00298 7.9e-233 pdp 2.4.2.2, 2.4.2.4 F phosphorylase
NHFKFMEO_00299 9.8e-206 nupC F Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NHFKFMEO_00300 2e-115 deoC 4.1.2.4 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NHFKFMEO_00301 2.3e-173 deoR K COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain
NHFKFMEO_00302 1.3e-151 yxxB S Domain of Unknown Function (DUF1206)
NHFKFMEO_00303 1.4e-198 eutH E Ethanolamine utilisation protein, EutH
NHFKFMEO_00304 1.7e-246 yxeQ S MmgE/PrpD family
NHFKFMEO_00305 4.4e-211 yxeP 3.5.1.47 E hydrolase activity
NHFKFMEO_00306 2.7e-132 yxeO 3.6.3.21 P ABC transporter, ATP-binding protein
NHFKFMEO_00307 1.2e-107 yxeN P COG0765 ABC-type amino acid transport system, permease component
NHFKFMEO_00308 2.5e-144 yxeM M Belongs to the bacterial solute-binding protein 3 family
NHFKFMEO_00309 1.6e-93 yxeL K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
NHFKFMEO_00310 1.1e-253 yxeK C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NHFKFMEO_00311 1e-187 yxeI 3.5.1.24 M Linear amide C-N hydrolases, choloylglycine hydrolase family
NHFKFMEO_00312 5.2e-150 yidA S hydrolases of the HAD superfamily
NHFKFMEO_00315 1.3e-20 yxeE
NHFKFMEO_00316 1.9e-16 yxeD
NHFKFMEO_00317 8.5e-69
NHFKFMEO_00318 6.6e-176 fhuD P ABC transporter
NHFKFMEO_00319 1.5e-58 yxeA S Protein of unknown function (DUF1093)
NHFKFMEO_00320 0.0 yxdM V ABC transporter (permease)
NHFKFMEO_00321 9.4e-141 yxdL V ABC transporter, ATP-binding protein
NHFKFMEO_00322 4.5e-180 T PhoQ Sensor
NHFKFMEO_00323 4.2e-124 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
NHFKFMEO_00324 1.6e-160 iolJ 4.1.2.13, 4.1.2.29 F Produces dihydroxyacetone phosphate (DHAP or glycerone phosphate) and malonic semialdehyde (MSA or 3-oxopropanoate) from 6-phospho-5-dehydro-2-deoxy-D-gluconate (DKGP)
NHFKFMEO_00325 2.3e-137 iolI 5.3.99.11 G Involved in the reversible interconverion of 2-keto-myo- inositol (2KMI, inosose or 2,4,6 3,5-pentahydroxycyclohexanone) to 1-keto-D-chiro-inositol (1KDCI or 2,3,5 4,6- pentahydroxycyclohexanone)
NHFKFMEO_00326 8.6e-167 iolH G Xylose isomerase-like TIM barrel
NHFKFMEO_00327 2.8e-196 iolG 1.1.1.18, 1.1.1.369 S Involved in the oxidation of myo-inositol (MI) and D- chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively
NHFKFMEO_00328 5.1e-235 iolF EGP Major facilitator Superfamily
NHFKFMEO_00329 2.1e-176 iolE 4.2.1.44 G Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol)
NHFKFMEO_00330 0.0 iolD 3.7.1.22 E Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG)
NHFKFMEO_00331 1.4e-178 iolC 2.7.1.92 G Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D- gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5- dehydro-2-deoxy-D-gluconate (DKGP)
NHFKFMEO_00332 9.2e-155 iolB 5.3.1.30 G Involved in the isomerization of 5-deoxy-glucuronate (5DG) to 5-dehydro-2-deoxy-D-gluconate (DKG or 2-deoxy-5-keto-D- gluconate)
NHFKFMEO_00333 1.4e-281 iolA 1.2.1.18, 1.2.1.27 C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
NHFKFMEO_00334 3.3e-138 iolR K COG1349 Transcriptional regulators of sugar metabolism
NHFKFMEO_00335 8.3e-176 iolS C Aldo keto reductase
NHFKFMEO_00337 2.4e-47 yxcD S Protein of unknown function (DUF2653)
NHFKFMEO_00338 1.1e-245 csbC EGP Major facilitator Superfamily
NHFKFMEO_00339 0.0 htpG O Molecular chaperone. Has ATPase activity
NHFKFMEO_00341 3.1e-150 IQ Enoyl-(Acyl carrier protein) reductase
NHFKFMEO_00342 1.6e-208 yxbF K Bacterial regulatory proteins, tetR family
NHFKFMEO_00343 3.2e-245 alkH 1.2.1.3 C Belongs to the aldehyde dehydrogenase family
NHFKFMEO_00344 4.5e-24 yxaI S membrane protein domain
NHFKFMEO_00345 4.4e-92 S PQQ-like domain
NHFKFMEO_00346 1.8e-64 S Family of unknown function (DUF5391)
NHFKFMEO_00347 1.4e-75 yxaI S membrane protein domain
NHFKFMEO_00348 1.6e-227 P Protein of unknown function (DUF418)
NHFKFMEO_00349 1.1e-192 yxaG 1.13.11.24 S AraC-like ligand binding domain
NHFKFMEO_00350 2.1e-100 yxaF K Transcriptional regulator
NHFKFMEO_00351 2.5e-200 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
NHFKFMEO_00352 4.4e-71 yxaD K helix_turn_helix multiple antibiotic resistance protein
NHFKFMEO_00353 5.2e-50 S LrgA family
NHFKFMEO_00354 1.3e-117 yxaC M effector of murein hydrolase
NHFKFMEO_00355 3.5e-191 yxaB GM Polysaccharide pyruvyl transferase
NHFKFMEO_00356 1.2e-205 glxK 2.7.1.165 G Belongs to the glycerate kinase type-1 family
NHFKFMEO_00357 7.3e-127 gntR K transcriptional
NHFKFMEO_00358 1.2e-301 gntK 2.7.1.12, 2.7.1.17, 2.7.1.5 G Belongs to the FGGY kinase family
NHFKFMEO_00359 7.7e-231 gntP EG COG2610 H gluconate symporter and related permeases
NHFKFMEO_00360 3.8e-273 gnd 1.1.1.343, 1.1.1.44 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NHFKFMEO_00361 2.1e-105 ahpC 1.11.1.15 O Alkyl hydroperoxide reductase
NHFKFMEO_00362 1.9e-286 ahpF O Alkyl hydroperoxide reductase
NHFKFMEO_00363 5.4e-291 bglA 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
NHFKFMEO_00364 3.4e-27 2.7.1.199 G phosphoenolpyruvate-dependent sugar phosphotransferase system
NHFKFMEO_00365 1.9e-124 yydK K Transcriptional regulator
NHFKFMEO_00366 1.6e-118 S ABC-2 family transporter protein
NHFKFMEO_00367 1.6e-109 prrC P ABC transporter
NHFKFMEO_00368 0.0 fbp 3.1.3.11 G Firmicute fructose-1,6-bisphosphatase
NHFKFMEO_00369 1.3e-202 S SIR2-like domain
NHFKFMEO_00370 1.6e-181 L DNA synthesis involved in DNA repair
NHFKFMEO_00371 5.2e-81 rlmH 2.1.1.177 J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NHFKFMEO_00372 1.1e-09 S YyzF-like protein
NHFKFMEO_00373 5.3e-66
NHFKFMEO_00374 3.9e-234 fdhA 1.1.1.1, 1.1.1.14, 1.1.1.284, 1.2.1.46 E COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
NHFKFMEO_00376 1.7e-30 yycQ S Protein of unknown function (DUF2651)
NHFKFMEO_00377 5.4e-201 yycP
NHFKFMEO_00378 8.4e-131 yycO S Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
NHFKFMEO_00379 1.4e-83 yycN 2.3.1.128 K Acetyltransferase
NHFKFMEO_00380 1.1e-187 S aspartate phosphatase
NHFKFMEO_00382 2.3e-167 rocF 3.5.3.1, 3.5.3.11 E Belongs to the arginase family
NHFKFMEO_00383 1.3e-260 rocE E amino acid
NHFKFMEO_00384 2.5e-233 rocD 2.6.1.11, 2.6.1.13, 2.6.1.17 E Catalyzes the interconversion of ornithine to glutamate semialdehyde
NHFKFMEO_00385 7.4e-16
NHFKFMEO_00386 2.8e-94
NHFKFMEO_00387 2.3e-24 S Sporulation delaying protein SdpA
NHFKFMEO_00388 1.5e-59 S Immunity protein that provides protection for the cell against the toxic effects of SDP, its own SdpC-derived killing factor, and that functions as a receptor signal transduction protein as well. Once SDP accumulates in the extracellular milieu, SdpI binds to SDP, causing sequestration of SdpR at the bacterial membrane
NHFKFMEO_00389 1.5e-40 sdpR K transcriptional
NHFKFMEO_00390 1.5e-258 rocR KT COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains
NHFKFMEO_00391 2.3e-172 phoR3 2.7.13.3 T COG0642 Signal transduction histidine kinase
NHFKFMEO_00392 1.5e-94 K PFAM response regulator receiver
NHFKFMEO_00393 5.2e-74 S Peptidase propeptide and YPEB domain
NHFKFMEO_00394 2.5e-17 S Peptidase propeptide and YPEB domain
NHFKFMEO_00395 8.7e-218 htrA 3.4.21.107 O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NHFKFMEO_00396 1.9e-149 vicX 3.1.26.11 S COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I
NHFKFMEO_00397 1.8e-153 yycI S protein conserved in bacteria
NHFKFMEO_00398 4.4e-258 yycH S protein conserved in bacteria
NHFKFMEO_00399 0.0 vicK 2.7.13.3 T Histidine kinase
NHFKFMEO_00400 1.1e-132 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
NHFKFMEO_00405 3e-248 purA 6.3.4.4 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NHFKFMEO_00406 2e-76 yycE 3.4.21.26, 5.3.1.24 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
NHFKFMEO_00407 3e-251 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
NHFKFMEO_00408 1.9e-29 yycD S Uncharacterized protein conserved in bacteria (DUF2188)
NHFKFMEO_00410 1.9e-15 yycC K YycC-like protein
NHFKFMEO_00411 2.5e-220 yeaN P COG2807 Cyanate permease
NHFKFMEO_00412 0.0 yycA M COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NHFKFMEO_00413 2.2e-73 rplI J binds to the 23S rRNA
NHFKFMEO_00414 0.0 yybT T signaling protein consisting of a modified GGDEF domain and a DHH domain
NHFKFMEO_00415 8.3e-160 yybS S membrane
NHFKFMEO_00417 3.3e-83 cotF M Spore coat protein
NHFKFMEO_00418 1.7e-66 ydeP3 K Transcriptional regulator
NHFKFMEO_00419 1.6e-163 ppaC 3.6.1.1 C Inorganic pyrophosphatase
NHFKFMEO_00420 1.5e-58
NHFKFMEO_00422 1.8e-240 yybO G COG0477 Permeases of the major facilitator superfamily
NHFKFMEO_00423 8.2e-110 K TipAS antibiotic-recognition domain
NHFKFMEO_00424 2.4e-123
NHFKFMEO_00425 2.9e-66 yybH S SnoaL-like domain
NHFKFMEO_00426 4e-121 yybG S Pentapeptide repeat-containing protein
NHFKFMEO_00427 1.7e-216 ynfM EGP Major facilitator Superfamily
NHFKFMEO_00428 5.8e-163 yybE K Transcriptional regulator
NHFKFMEO_00429 2e-79 yjcF S Acetyltransferase (GNAT) domain
NHFKFMEO_00430 3e-76 yybC
NHFKFMEO_00431 3.3e-126 S Metallo-beta-lactamase superfamily
NHFKFMEO_00432 5.6e-77 yybA 2.3.1.57 K transcriptional
NHFKFMEO_00433 6.5e-70 yjcF S Acetyltransferase (GNAT) domain
NHFKFMEO_00434 2.5e-96 yyaS S Membrane
NHFKFMEO_00435 3.2e-92 yyaR K Acetyltransferase (GNAT) domain
NHFKFMEO_00436 1.3e-65 yyaQ S YjbR
NHFKFMEO_00437 1e-104 yyaP 1.5.1.3 H RibD C-terminal domain
NHFKFMEO_00438 1.6e-244 tetL EGP Major facilitator Superfamily
NHFKFMEO_00440 4.2e-173 1.1.1.1 C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases
NHFKFMEO_00441 3.2e-109 C Enoyl-(Acyl carrier protein) reductase
NHFKFMEO_00442 2.2e-86 K Bacterial regulatory proteins, tetR family
NHFKFMEO_00443 6.8e-79 T Nacht domain
NHFKFMEO_00444 7.2e-20 L Recombinase
NHFKFMEO_00445 3.5e-28 L Recombinase
NHFKFMEO_00446 3e-24 V VanZ like family
NHFKFMEO_00447 3e-29
NHFKFMEO_00449 1.1e-66 S response regulator aspartate phosphatase
NHFKFMEO_00450 7.3e-48 D nuclear chromosome segregation
NHFKFMEO_00451 8.3e-24 yyaL O COG1331 Highly conserved protein containing a thioredoxin domain
NHFKFMEO_00452 0.0 yyaL O COG1331 Highly conserved protein containing a thioredoxin domain
NHFKFMEO_00453 3.6e-168 yyaK S CAAX protease self-immunity
NHFKFMEO_00454 6.1e-244 EGP Major facilitator superfamily
NHFKFMEO_00455 9.6e-95 maa 2.3.1.79 S Bacterial transferase hexapeptide (six repeats)
NHFKFMEO_00456 3.4e-67 yyaH 4.4.1.5 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
NHFKFMEO_00457 4e-178 ccpB 3.5.1.4, 5.1.1.1 K Transcriptional regulator
NHFKFMEO_00458 3.4e-143 xth 3.1.11.2 L exodeoxyribonuclease III
NHFKFMEO_00459 5.1e-37 rpsR J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NHFKFMEO_00460 2.9e-69 ssb L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
NHFKFMEO_00461 4.3e-46 rpsF J Binds together with S18 to 16S ribosomal RNA
NHFKFMEO_00462 4e-201 ychF J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
NHFKFMEO_00463 2.3e-33 yyzM S protein conserved in bacteria
NHFKFMEO_00464 8.1e-177 yyaD S Membrane
NHFKFMEO_00465 1.6e-111 yyaC S Sporulation protein YyaC
NHFKFMEO_00466 2.1e-149 spo0J K Belongs to the ParB family
NHFKFMEO_00467 2.2e-134 soj D COG1192 ATPases involved in chromosome partitioning
NHFKFMEO_00468 9.6e-74 S Bacterial PH domain
NHFKFMEO_00469 5.5e-150 noc D Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage
NHFKFMEO_00470 1.4e-130 rsmG 2.1.1.170 J Specifically methylates the N7 position of guanine in position 535 of 16S rRNA
NHFKFMEO_00471 0.0 gidA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
NHFKFMEO_00472 1.3e-249 mnmE S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NHFKFMEO_00473 6.5e-108 jag S single-stranded nucleic acid binding R3H
NHFKFMEO_00474 1.7e-118 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
NHFKFMEO_00475 3e-54 rnpA 3.1.26.5 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
NHFKFMEO_00476 6e-252 dnaA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NHFKFMEO_00477 1.8e-204 dnaN 2.7.7.7 L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
NHFKFMEO_00478 2.4e-33 yaaA S S4 domain
NHFKFMEO_00479 1.3e-204 recF L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NHFKFMEO_00480 1.8e-37 yaaB S Domain of unknown function (DUF370)
NHFKFMEO_00481 0.0 gyrB 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NHFKFMEO_00482 0.0 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NHFKFMEO_00484 8.9e-83 ydcK S Belongs to the SprT family
NHFKFMEO_00485 0.0 yhgF K COG2183 Transcriptional accessory protein
NHFKFMEO_00486 2.3e-75 ydcH K helix_turn_helix multiple antibiotic resistance protein
NHFKFMEO_00487 1.5e-82 ydcG S EVE domain
NHFKFMEO_00491 4.8e-108 rsbX 3.1.3.16, 3.1.3.3 KT Sigma factor PP2C-like phosphatases
NHFKFMEO_00492 3.4e-138 sigB K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NHFKFMEO_00493 2.4e-86 rsbW 2.7.11.1 F Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B)
NHFKFMEO_00494 7e-53 rsbV T Belongs to the anti-sigma-factor antagonist family
NHFKFMEO_00495 7.1e-189 rsbU 3.1.3.3 KT phosphatase
NHFKFMEO_00496 1.3e-69 rsbT 2.7.11.1 T COG2172 Anti-sigma regulatory factor (Ser Thr protein kinase)
NHFKFMEO_00497 5.2e-57 rsbS T antagonist
NHFKFMEO_00498 1.3e-143 rsbR T Positive regulator of sigma-B
NHFKFMEO_00499 2.5e-56 ndoA L Toxic component of a toxin-antitoxin (TA) module
NHFKFMEO_00500 4.8e-42 ndoAI K transcriptional regulators containing the CopG Arc MetJ DNA-binding domain and a metal-binding domain
NHFKFMEO_00501 2.1e-221 alr 5.1.1.1, 5.1.1.5 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NHFKFMEO_00502 3.2e-182 ydcC M COG2834 Outer membrane lipoprotein-sorting protein
NHFKFMEO_00503 2.1e-58 acpS 2.7.6.3, 2.7.8.7, 5.1.1.1 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
NHFKFMEO_00504 1.8e-107 ydcA 3.4.21.105 S membrane protein (homolog of Drosophila rhomboid)
NHFKFMEO_00505 3.6e-258 ydbT S Membrane
NHFKFMEO_00506 2.1e-82 ydbS S Bacterial PH domain
NHFKFMEO_00507 9e-249 cshA 3.6.4.13 JKL DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
NHFKFMEO_00508 2.3e-254 murF 6.3.2.10 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
NHFKFMEO_00509 3.9e-201 ddl 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
NHFKFMEO_00510 2.3e-56 ydbP 2.7.1.180, 5.3.4.1 CO Thioredoxin
NHFKFMEO_00511 2.5e-150 yeaB P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NHFKFMEO_00512 2.2e-07 S Fur-regulated basic protein A
NHFKFMEO_00513 1.1e-18 S Fur-regulated basic protein B
NHFKFMEO_00514 3e-220 ydbM 1.3.8.1 I acyl-CoA dehydrogenase
NHFKFMEO_00515 2.7e-52 ydbL
NHFKFMEO_00516 9.4e-125 ydbK S COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
NHFKFMEO_00517 3.6e-171 ydbJ V ABC transporter, ATP-binding protein
NHFKFMEO_00519 9.7e-181 ydbI S AI-2E family transporter
NHFKFMEO_00520 1.4e-226 dctA U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
NHFKFMEO_00521 5.2e-119 dctR T COG4565 Response regulator of citrate malate metabolism
NHFKFMEO_00522 3.6e-296 dctS 2.7.13.3 T Signal transduction histidine kinase regulating citrate malate metabolism
NHFKFMEO_00523 2.7e-199 dctB G COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component
NHFKFMEO_00524 3.5e-154 ydbD P Catalase
NHFKFMEO_00525 2.6e-61 ydbC S Domain of unknown function (DUF4937
NHFKFMEO_00526 6.8e-56 ydbB G Cupin domain
NHFKFMEO_00528 2.7e-146 ydbA 3.6.3.4, 3.6.3.54 P EcsC protein family
NHFKFMEO_00529 3.3e-77 ydaT S Uncharacterized protein conserved in bacteria (DUF2188)
NHFKFMEO_00531 5e-224 mntH P H( )-stimulated, divalent metal cation uptake system
NHFKFMEO_00532 9.4e-40
NHFKFMEO_00533 0.0 poxB 1.2.3.3, 1.2.5.1 EH Belongs to the TPP enzyme family
NHFKFMEO_00534 2.5e-77 mutT 3.6.1.13, 3.6.1.55 L Belongs to the Nudix hydrolase family
NHFKFMEO_00535 0.0 ydaO E amino acid
NHFKFMEO_00536 0.0 ydaN S Bacterial cellulose synthase subunit
NHFKFMEO_00537 1.3e-232 ydaM M Glycosyl transferase family group 2
NHFKFMEO_00538 0.0 ydaL S Uncharacterized protein conserved in bacteria (DUF2334)
NHFKFMEO_00539 1.1e-150 ydaK T Diguanylate cyclase, GGDEF domain
NHFKFMEO_00540 5.8e-205 ydaJ M Belongs to the glycosyl hydrolase 8 (cellulase D) family
NHFKFMEO_00541 0.0 topB 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NHFKFMEO_00542 2.5e-74 lrpC K Transcriptional regulator
NHFKFMEO_00543 3.3e-46 ydzA EGP Major facilitator Superfamily
NHFKFMEO_00544 5.4e-139 amj U Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane
NHFKFMEO_00545 6.8e-77 ydaG 1.4.3.5 S general stress protein
NHFKFMEO_00546 2.1e-102 rimL 1.1.1.25 J COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
NHFKFMEO_00547 1.2e-96 MA20_27600 5.3.1.15 S Cupin 2, conserved barrel domain protein
NHFKFMEO_00548 4.1e-161 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
NHFKFMEO_00549 3.5e-293 ydaB IQ acyl-CoA ligase
NHFKFMEO_00550 0.0 mtlR K transcriptional regulator, MtlR
NHFKFMEO_00551 9.2e-172 ydhF S Oxidoreductase
NHFKFMEO_00552 0.0 pbpC 3.4.16.4 M Penicillin-binding Protein
NHFKFMEO_00553 8e-47 yczJ S biosynthesis
NHFKFMEO_00555 7.1e-118 ycsK E anatomical structure formation involved in morphogenesis
NHFKFMEO_00556 6e-132 kipR K Transcriptional regulator
NHFKFMEO_00557 5.1e-187 kipA 6.3.4.6 E Allophanate hydrolase subunit 2
NHFKFMEO_00558 3.6e-134 kipI 3.5.1.54 E Allophanate hydrolase subunit 1
NHFKFMEO_00559 3.7e-148 ycsI S Belongs to the D-glutamate cyclase family
NHFKFMEO_00560 1.6e-211 ycsG P COG1914 Mn2 and Fe2 transporters of the NRAMP family
NHFKFMEO_00561 1.2e-140 ycsF S Belongs to the UPF0271 (lamB) family
NHFKFMEO_00562 2.3e-136 ycsE 3.1.3.104 S Sucrose-6F-phosphate phosphohydrolase
NHFKFMEO_00564 1.6e-67 fabZ 3.5.1.108, 4.2.1.59 I FabA-like domain
NHFKFMEO_00565 6.8e-110 M1-673 3.1.1.45 Q COG0412 Dienelactone hydrolase and related enzymes
NHFKFMEO_00566 2.2e-75 sipT 3.4.21.89 U Belongs to the peptidase S26 family
NHFKFMEO_00568 3.8e-201 ycsA 1.1.1.83, 1.1.1.93, 4.1.1.73 CE Tartrate dehydrogenase
NHFKFMEO_00569 1.8e-209 mtlD 1.1.1.17 G COG0246 Mannitol-1-phosphate altronate dehydrogenases
NHFKFMEO_00570 3.4e-71 mtlF 2.7.1.197 G COG4668 Mannitol fructose-specific phosphotransferase system, IIA domain
NHFKFMEO_00571 7.4e-240 mtlA 2.7.1.197 G COG2213 Phosphotransferase system, mannitol-specific IIBC component
NHFKFMEO_00572 6.8e-54
NHFKFMEO_00573 2.8e-105 ycnK K COG1349 Transcriptional regulators of sugar metabolism
NHFKFMEO_00574 1.4e-308 ycnJ P protein, homolog of Cu resistance protein CopC
NHFKFMEO_00575 1.4e-99 ycnI S protein conserved in bacteria
NHFKFMEO_00576 9.9e-146 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
NHFKFMEO_00577 6.1e-149 glcU U Glucose uptake
NHFKFMEO_00578 1.9e-264 gabD 1.2.1.16, 1.2.1.20, 1.2.1.79 C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
NHFKFMEO_00579 6.9e-245 gabT 2.6.1.19, 2.6.1.22 E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NHFKFMEO_00580 8.6e-273 gabR K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
NHFKFMEO_00581 2.2e-51 yczG K helix_turn_helix, Arsenical Resistance Operon Repressor
NHFKFMEO_00582 1.6e-45 ycnE S Monooxygenase
NHFKFMEO_00583 4.4e-135 nfrA2 1.5.1.38, 1.5.1.39 C Oxidoreductase
NHFKFMEO_00584 6.5e-154 ycnC K Transcriptional regulator
NHFKFMEO_00585 3.2e-251 ycnB EGP Major facilitator Superfamily
NHFKFMEO_00586 5.5e-175 yclQ P COG4607 ABC-type enterochelin transport system, periplasmic component
NHFKFMEO_00587 4.7e-137 yclP 3.6.3.34 P ABC transporter, ATP-binding protein
NHFKFMEO_00588 2.6e-164 fatC P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NHFKFMEO_00589 5.9e-161 yclN P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NHFKFMEO_00590 1.7e-241 lysC 2.7.2.4 E Belongs to the aspartokinase family
NHFKFMEO_00594 5.2e-71 S aspartate phosphatase
NHFKFMEO_00595 8.3e-260 yclK 2.7.13.3 T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain
NHFKFMEO_00596 1.4e-127 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
NHFKFMEO_00597 1.1e-195 yclI V ABC transporter (permease) YclI
NHFKFMEO_00598 7.3e-121 yclH P ABC transporter
NHFKFMEO_00599 3e-196 gerKB F Spore germination protein
NHFKFMEO_00600 1.6e-230 gerKC S spore germination
NHFKFMEO_00601 9.2e-279 gerKA EG Spore germination protein
NHFKFMEO_00603 1.1e-293 yclG M Pectate lyase superfamily protein
NHFKFMEO_00604 4.7e-266 dtpT E amino acid peptide transporter
NHFKFMEO_00605 7.6e-160 yclE 3.4.11.5 S Alpha beta hydrolase
NHFKFMEO_00606 7e-83 yclD
NHFKFMEO_00607 4e-39 bsdD 4.1.1.61 S response to toxic substance
NHFKFMEO_00608 2.2e-281 yclC 4.1.1.61 H Decarboxylase involved in the decarboxylation and detoxification of phenolic derivatives under both aerobic and anaerobic conditions. It is able to catalyze the reversible decarboxylation of 4-hydroxybenzoate
NHFKFMEO_00609 3.7e-108 ubiX 2.5.1.129 H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN
NHFKFMEO_00610 1.9e-161 bsdA K LysR substrate binding domain
NHFKFMEO_00611 5.4e-139 tcyA ET Belongs to the bacterial solute-binding protein 3 family
NHFKFMEO_00612 6.2e-123 tcyB P COG0765 ABC-type amino acid transport system, permease component
NHFKFMEO_00613 2.8e-134 tcyC 3.6.3.21 E COG1126 ABC-type polar amino acid transport system, ATPase component
NHFKFMEO_00614 9.7e-115 yczE S membrane
NHFKFMEO_00615 2.9e-114 acpT 2.7.8.7 H Belongs to the P-Pant transferase superfamily
NHFKFMEO_00616 2.5e-250 ycxD K GntR family transcriptional regulator
NHFKFMEO_00617 1.3e-160 ycxC EG EamA-like transporter family
NHFKFMEO_00618 1.9e-87 S YcxB-like protein
NHFKFMEO_00619 7.5e-225 EGP Major Facilitator Superfamily
NHFKFMEO_00620 1.7e-139 srfAD Q thioesterase
NHFKFMEO_00621 0.0 srfAC Q COG1020 Non-ribosomal peptide synthetase modules and related proteins
NHFKFMEO_00622 0.0 srfAB Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
NHFKFMEO_00623 0.0 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
NHFKFMEO_00624 2.3e-195 pheS 6.1.1.20 J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NHFKFMEO_00625 3.1e-133 spoU 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NHFKFMEO_00626 2.6e-32 sspI S Belongs to the SspI family
NHFKFMEO_00627 7.7e-205 ysfB KT regulator
NHFKFMEO_00628 6.1e-263 glcD 1.1.3.15 C Glycolate oxidase subunit
NHFKFMEO_00629 8.1e-257 glcF C Glycolate oxidase
NHFKFMEO_00630 8.1e-53 ysfE 4.4.1.5 E Glyoxalase-like domain
NHFKFMEO_00632 0.0 cstA T Carbon starvation protein
NHFKFMEO_00633 4.6e-301 abfA 3.2.1.55 GH51 G alpha-L-arabinofuranosidase activity
NHFKFMEO_00634 3.8e-143 araQ G transport system permease
NHFKFMEO_00635 1.4e-167 araP G carbohydrate transport
NHFKFMEO_00636 1.1e-250 araN G carbohydrate transport
NHFKFMEO_00637 6.2e-216 egsA 1.1.1.261 I Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is probably used for the synthesis of phosphoglycerolipids in Gram-positive bacterial species
NHFKFMEO_00638 1e-145 araL 3.1.3.41 G Haloacid dehalogenase-like hydrolase
NHFKFMEO_00639 1.9e-132 araD 4.1.2.17, 4.2.1.109, 5.1.3.4 G COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases
NHFKFMEO_00640 0.0 araB 2.7.1.16 C Belongs to the ribulokinase family
NHFKFMEO_00641 3.2e-294 araA 5.3.1.4 G Catalyzes the conversion of L-arabinose to L-ribulose
NHFKFMEO_00642 5.2e-189 abnA 3.2.1.99 GH43 G Belongs to the glycosyl hydrolase 43 family
NHFKFMEO_00643 7.6e-205 ysdC G COG1363 Cellulase M and related proteins
NHFKFMEO_00644 3.5e-67 ysdB S Sigma-w pathway protein YsdB
NHFKFMEO_00645 7.5e-45 ysdA S Membrane
NHFKFMEO_00646 3.6e-58 rplT J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NHFKFMEO_00647 9e-27 rpmI J Belongs to the bacterial ribosomal protein bL35 family
NHFKFMEO_00648 3.3e-86 infC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NHFKFMEO_00650 2.4e-111 lrgB M Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses
NHFKFMEO_00651 1.1e-48 lrgA S Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses
NHFKFMEO_00652 3.1e-130 lytT T COG3279 Response regulator of the LytR AlgR family
NHFKFMEO_00653 0.0 lytS 2.7.13.3 T Histidine kinase
NHFKFMEO_00654 4.7e-148 ysaA S HAD-hyrolase-like
NHFKFMEO_00655 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NHFKFMEO_00657 1.4e-158 ytxC S YtxC-like family
NHFKFMEO_00658 4.9e-111 ytxB S SNARE associated Golgi protein
NHFKFMEO_00659 3e-173 dnaI L Primosomal protein DnaI
NHFKFMEO_00660 1.5e-264 dnaB L Membrane attachment protein
NHFKFMEO_00661 1.1e-80 nrdR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NHFKFMEO_00662 2e-67 speH 4.1.1.50 E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
NHFKFMEO_00663 2.8e-193 gapB 1.2.1.12, 1.2.1.59 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
NHFKFMEO_00664 9.9e-67 ytcD K Transcriptional regulator
NHFKFMEO_00665 7.3e-201 ytbD EGP Major facilitator Superfamily
NHFKFMEO_00666 8.9e-161 ytbE S reductase
NHFKFMEO_00667 5.4e-96 coaE 2.7.1.24 F Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NHFKFMEO_00668 1.1e-107 ytaF P Probably functions as a manganese efflux pump
NHFKFMEO_00669 3.9e-156 fpg 3.2.2.23, 4.2.99.18 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
NHFKFMEO_00670 0.0 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NHFKFMEO_00671 0.0 phoR 2.7.13.3 T Signal transduction histidine kinase
NHFKFMEO_00672 2.2e-131 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
NHFKFMEO_00673 3.1e-170 mdh 1.1.1.37 C Catalyzes the reversible oxidation of malate to oxaloacetate
NHFKFMEO_00674 2.4e-242 icd 1.1.1.42 C isocitrate
NHFKFMEO_00675 4.7e-210 citZ 2.3.3.1 C Belongs to the citrate synthase family
NHFKFMEO_00676 1.4e-70 yeaL S membrane
NHFKFMEO_00677 9.9e-192 ytvI S sporulation integral membrane protein YtvI
NHFKFMEO_00678 8.7e-63 fxsA S COG3030 Protein affecting phage T7 exclusion by the F plasmid
NHFKFMEO_00679 0.0 pyk 2.7.1.40, 2.7.7.4 G Belongs to the pyruvate kinase family
NHFKFMEO_00680 1.3e-179 pfkA 2.7.1.11 F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
NHFKFMEO_00681 4.3e-183 accA 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
NHFKFMEO_00682 2.6e-169 accD 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NHFKFMEO_00683 1.5e-225 ytsJ 1.1.1.38 C Malate dehydrogenase
NHFKFMEO_00684 0.0 dnaE 2.7.7.7 L DNA polymerase
NHFKFMEO_00685 3.2e-56 ytrH S Sporulation protein YtrH
NHFKFMEO_00686 8.2e-69 ytrI
NHFKFMEO_00687 9.2e-29
NHFKFMEO_00688 7.8e-182 nrnA 3.1.13.3, 3.1.3.7 S COG0618 Exopolyphosphatase-related proteins
NHFKFMEO_00689 6.9e-47 ytpI S YtpI-like protein
NHFKFMEO_00690 8e-241 ytoI K transcriptional regulator containing CBS domains
NHFKFMEO_00691 1.2e-158 ytnM S membrane transporter protein
NHFKFMEO_00692 2.5e-236 ytnL 3.5.1.47 E hydrolase activity
NHFKFMEO_00693 9e-127 ribF 2.7.1.26, 2.7.7.2 H Riboflavin kinase
NHFKFMEO_00694 1.4e-253 moxC C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NHFKFMEO_00695 9.3e-46 ytnI O COG0695 Glutaredoxin and related proteins
NHFKFMEO_00696 1.8e-184 ytmO C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NHFKFMEO_00697 3.9e-142 tcyN 3.6.3.21 E COG1126 ABC-type polar amino acid transport system, ATPase component
NHFKFMEO_00698 7.1e-119 tcyM U Binding-protein-dependent transport system inner membrane component
NHFKFMEO_00699 3.1e-122 tcyL P Binding-protein-dependent transport system inner membrane component
NHFKFMEO_00700 1.4e-147 tcyK M Bacterial periplasmic substrate-binding proteins
NHFKFMEO_00701 2.3e-150 tcyK ET Bacterial periplasmic substrate-binding proteins
NHFKFMEO_00702 4.3e-100 ytmI K Acetyltransferase (GNAT) domain
NHFKFMEO_00703 1.6e-171 ytlI K LysR substrate binding domain
NHFKFMEO_00704 1.7e-130 ytkL S Belongs to the UPF0173 family
NHFKFMEO_00705 1.1e-141 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
NHFKFMEO_00707 8.9e-267 argH 4.3.2.1 E argininosuccinate lyase
NHFKFMEO_00708 2.3e-234 argG 6.3.4.5 E Belongs to the argininosuccinate synthase family. Type 1 subfamily
NHFKFMEO_00709 1.4e-87 moaB 2.7.7.75 H May be involved in the biosynthesis of molybdopterin
NHFKFMEO_00710 3.7e-221 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NHFKFMEO_00711 7e-165 ytxK 2.1.1.72 L DNA methylase
NHFKFMEO_00712 7.9e-88 tpx 1.11.1.15 O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
NHFKFMEO_00713 8.7e-70 ytfJ S Sporulation protein YtfJ
NHFKFMEO_00714 8.1e-115 ytfI S Protein of unknown function (DUF2953)
NHFKFMEO_00715 2.5e-86 yteJ S RDD family
NHFKFMEO_00716 2.3e-179 sppA OU signal peptide peptidase SppA
NHFKFMEO_00717 2.2e-148 nadK 2.7.1.23 G Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NHFKFMEO_00718 0.0 ytcJ S amidohydrolase
NHFKFMEO_00719 6.6e-306 acsA 6.2.1.1, 6.2.1.2 I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases
NHFKFMEO_00720 2e-29 sspB S spore protein
NHFKFMEO_00721 3.5e-227 thiI 2.8.1.4 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NHFKFMEO_00722 1e-207 iscS2 2.8.1.7 E Cysteine desulfurase
NHFKFMEO_00723 4.9e-238 brnQ E Component of the transport system for branched-chain amino acids
NHFKFMEO_00724 2e-273 ezrA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
NHFKFMEO_00725 8.6e-153 hisK 3.1.3.15 E COG1387 Histidinol phosphatase and related hydrolases of the PHP family
NHFKFMEO_00726 1e-108 yttP K Transcriptional regulator
NHFKFMEO_00727 2e-88 ytsP 1.8.4.14 T GAF domain-containing protein
NHFKFMEO_00728 0.0 ytrP 2.7.7.65 T COG2199 FOG GGDEF domain
NHFKFMEO_00729 2.5e-109 rpsD J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NHFKFMEO_00731 6.7e-237 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NHFKFMEO_00732 0.0 acsA 6.2.1.1 I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases
NHFKFMEO_00733 3.6e-122 acuA K Part of the acuABC operon, which is possibly involved in the breakdown of acetoin and butanediol. Acts as an acetyltransferase inactivating acetyl-CoA synthetase AcsA via acetylation at a Lys residue
NHFKFMEO_00734 1.6e-117 acuB S Domain in cystathionine beta-synthase and other proteins.
NHFKFMEO_00735 3.6e-224 acuC BQ histone deacetylase
NHFKFMEO_00736 1.4e-125 motS N Flagellar motor protein
NHFKFMEO_00737 2.1e-146 motA N flagellar motor
NHFKFMEO_00738 1.7e-182 ccpA K catabolite control protein A
NHFKFMEO_00739 4.9e-196 aroF 2.5.1.54, 5.4.99.5 E Catalyzes the formation of 3-deoxy-D-aribino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate and the formation of prephenate from chorismate
NHFKFMEO_00740 4.4e-55 ytxJ O Protein of unknown function (DUF2847)
NHFKFMEO_00741 6.6e-17 ytxH S COG4980 Gas vesicle protein
NHFKFMEO_00742 2.1e-17 ytxG S protein containing a divergent version of the methyl-accepting chemotaxis-like domain
NHFKFMEO_00743 1.6e-254 mpl 6.3.2.4, 6.3.2.45, 6.3.2.8 M Belongs to the MurCDEF family
NHFKFMEO_00744 0.0 sftA D Belongs to the FtsK SpoIIIE SftA family
NHFKFMEO_00745 2.8e-108 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
NHFKFMEO_00746 9.8e-149 ytpQ S Belongs to the UPF0354 family
NHFKFMEO_00747 1.3e-56 ytpP 2.7.1.180, 5.3.4.1 CO Thioredoxin
NHFKFMEO_00748 5.9e-79 ytoQ S Nucleoside 2-deoxyribosyltransferase YtoQ
NHFKFMEO_00749 4e-206 pepA 3.4.11.7 G COG1363 Cellulase M and related proteins
NHFKFMEO_00750 1.1e-50 ytzB S small secreted protein
NHFKFMEO_00751 0.0 sfcA 1.1.1.38 C Malate dehydrogenase
NHFKFMEO_00752 8.4e-151 ytnP S COG0491 Zn-dependent hydrolases, including glyoxylases
NHFKFMEO_00753 1.4e-121 trmB 2.1.1.297, 2.1.1.33 J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
NHFKFMEO_00754 2e-45 ytzH S YtzH-like protein
NHFKFMEO_00755 6.1e-151 ytmP 2.7.1.89 M Phosphotransferase
NHFKFMEO_00756 0.0 pulA 3.2.1.41 CBM48,GH13 G Belongs to the glycosyl hydrolase 13 family
NHFKFMEO_00757 8.6e-181 ytlR 2.7.1.91 I Diacylglycerol kinase catalytic domain
NHFKFMEO_00758 1.3e-165 ytlQ
NHFKFMEO_00759 3e-101 ligT 3.1.4.58, 3.5.1.42 J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
NHFKFMEO_00760 8.6e-173 ytkP 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
NHFKFMEO_00761 2.7e-271 pepV 3.5.1.18 E Dipeptidase
NHFKFMEO_00762 2.1e-225 pbuO S permease
NHFKFMEO_00763 4.2e-201 ythQ U Bacterial ABC transporter protein EcsB
NHFKFMEO_00764 1.4e-130 ythP V ABC transporter
NHFKFMEO_00765 2.4e-33 ytzE K COG1349 Transcriptional regulators of sugar metabolism
NHFKFMEO_00766 4.8e-131 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
NHFKFMEO_00767 2.5e-292 ytgP S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
NHFKFMEO_00768 1.1e-231 ytfP S HI0933-like protein
NHFKFMEO_00769 1.3e-282 opuD M Belongs to the BCCT transporter (TC 2.A.15) family
NHFKFMEO_00770 3.1e-26 yteV S Sporulation protein Cse60
NHFKFMEO_00771 5.9e-115 yteU S Integral membrane protein
NHFKFMEO_00772 3e-256 yteT S Oxidoreductase family, C-terminal alpha/beta domain
NHFKFMEO_00773 5.1e-72 yteS G transport
NHFKFMEO_00774 5.9e-221 yteR 3.2.1.172 GH105 G unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins
NHFKFMEO_00775 1.7e-171 lplB G COG4209 ABC-type polysaccharide transport system, permease component
NHFKFMEO_00776 0.0 ytdP K Transcriptional regulator
NHFKFMEO_00777 1.8e-289 ytcQ G COG1653 ABC-type sugar transport system, periplasmic component
NHFKFMEO_00778 1.3e-149 ytcP G COG0395 ABC-type sugar transport system, permease component
NHFKFMEO_00779 1.2e-135 udh 1.1.1.203, 1.1.1.388 GM NAD dependent epimerase/dehydratase family
NHFKFMEO_00780 1.7e-221 bioI 1.14.14.46 C Cytochrome P450
NHFKFMEO_00781 5.4e-189 bioB 2.8.1.6 H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NHFKFMEO_00782 2.9e-125 bioD 6.3.3.3 H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NHFKFMEO_00783 2.3e-215 bioF 2.3.1.29, 2.3.1.47, 6.2.1.14 H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide
NHFKFMEO_00784 6e-260 bioA 2.6.1.105, 2.6.1.62 H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor
NHFKFMEO_00785 8.9e-141 bioW 2.3.1.47, 6.2.1.14 H Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
NHFKFMEO_00786 3.2e-172 ytaP S Acetyl xylan esterase (AXE1)
NHFKFMEO_00787 1.5e-189 msmR K Transcriptional regulator
NHFKFMEO_00788 1.3e-243 msmE G Bacterial extracellular solute-binding protein
NHFKFMEO_00789 6.2e-168 amyD P ABC transporter
NHFKFMEO_00790 1.1e-142 amyC P ABC transporter (permease)
NHFKFMEO_00791 5.8e-252 melA 3.2.1.122, 3.2.1.22, 3.2.1.86 GH4,GT4 G Family 4 glycosyl hydrolase
NHFKFMEO_00792 2.1e-51 ytwF P Sulfurtransferase
NHFKFMEO_00793 0.0 leuS 6.1.1.4 J Belongs to the class-I aminoacyl-tRNA synthetase family
NHFKFMEO_00794 7.7e-55 ytvB S Protein of unknown function (DUF4257)
NHFKFMEO_00795 6.6e-142 pfyP T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)
NHFKFMEO_00796 2.1e-211 yttB EGP Major facilitator Superfamily
NHFKFMEO_00797 3.9e-43 yttA 2.7.13.3 S Pfam Transposase IS66
NHFKFMEO_00798 0.0 bceB V ABC transporter (permease)
NHFKFMEO_00799 1.1e-138 bceA V ABC transporter, ATP-binding protein
NHFKFMEO_00800 1.8e-184 T PhoQ Sensor
NHFKFMEO_00801 2.8e-128 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
NHFKFMEO_00802 1.6e-233 ytrF V COG0577 ABC-type antimicrobial peptide transport system, permease component
NHFKFMEO_00803 9.1e-127 ytrE V ABC transporter, ATP-binding protein
NHFKFMEO_00804 9.8e-127
NHFKFMEO_00805 5.9e-148 P ABC-2 family transporter protein
NHFKFMEO_00806 4.2e-161 ytrB P abc transporter atp-binding protein
NHFKFMEO_00807 5.1e-66 ytrA K GntR family transcriptional regulator
NHFKFMEO_00809 6.7e-41 ytzC S Protein of unknown function (DUF2524)
NHFKFMEO_00810 1.8e-189 yhcC S Fe-S oxidoreductase
NHFKFMEO_00811 9.7e-106 ytqB J Putative rRNA methylase
NHFKFMEO_00812 7.5e-216 ytpB 4.2.3.130 S Tetraprenyl-beta-curcumene synthase
NHFKFMEO_00813 5.5e-149 ytpA 3.1.1.5 I Alpha beta hydrolase
NHFKFMEO_00814 1.1e-256 ytnA E COG1113 Gamma-aminobutyrate permease and related permeases
NHFKFMEO_00815 0.0 asnB 6.3.5.4 E Asparagine synthase
NHFKFMEO_00816 4.3e-225 metK 2.5.1.6 H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NHFKFMEO_00817 2e-310 pckA 4.1.1.49 C Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
NHFKFMEO_00818 1.2e-38 ytmB S Protein of unknown function (DUF2584)
NHFKFMEO_00819 1.6e-148 ytmA E COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases
NHFKFMEO_00820 3.6e-188 ytlA P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components
NHFKFMEO_00821 1.4e-144 ytlC P ABC transporter
NHFKFMEO_00822 6.8e-142 ytlD P COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component
NHFKFMEO_00823 2.8e-87 ytkD 3.6.1.55 L Belongs to the Nudix hydrolase family
NHFKFMEO_00824 6e-62 ytkC S Bacteriophage holin family
NHFKFMEO_00825 2.1e-76 dps P Belongs to the Dps family
NHFKFMEO_00827 6.9e-72 ytkA S YtkA-like
NHFKFMEO_00828 1.1e-86 luxS 4.4.1.21 T Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
NHFKFMEO_00829 5.7e-103 ytiB 4.2.1.1 P Reversible hydration of carbon dioxide
NHFKFMEO_00830 3.6e-41 rpmE2 J Ribosomal protein L31
NHFKFMEO_00831 1.1e-248 cydA 1.10.3.14 C oxidase, subunit
NHFKFMEO_00832 1.8e-187 cydB 1.10.3.14 C COG1294 Cytochrome bd-type quinol oxidase, subunit 2
NHFKFMEO_00833 1.1e-24 S Domain of Unknown Function (DUF1540)
NHFKFMEO_00834 1.4e-151 troD P 'COG1108 ABC-type Mn2 Zn2 transport systems, permease components'
NHFKFMEO_00835 3.7e-230 mntC P COG1108 ABC-type Mn2 Zn2 transport systems, permease components
NHFKFMEO_00836 7.3e-138 mntB P 'COG1121 ABC-type Mn Zn transport systems, ATPase component'
NHFKFMEO_00837 1.8e-170 troA P Belongs to the bacterial solute-binding protein 9 family
NHFKFMEO_00838 5.4e-214 menC 4.2.1.113 H Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)
NHFKFMEO_00839 1.2e-274 menE 6.2.1.26 H Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily
NHFKFMEO_00840 4.2e-155 menB 4.1.3.36 H Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NHFKFMEO_00841 1.4e-153 menH 4.2.99.20 S Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC)
NHFKFMEO_00842 0.0 menD 2.2.1.9 H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NHFKFMEO_00843 1.9e-272 menF 5.4.4.2 HQ Isochorismate synthase
NHFKFMEO_00844 4.4e-132 dksA T COG1734 DnaK suppressor protein
NHFKFMEO_00845 1e-153 galU 2.7.7.9 M Nucleotidyl transferase
NHFKFMEO_00846 1.6e-241 ugd 1.1.1.22 M Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NHFKFMEO_00847 1.1e-180 ytcB 5.1.3.2 M NAD-dependent epimerase dehydratase
NHFKFMEO_00848 3.7e-232 ytcC M Glycosyltransferase Family 4
NHFKFMEO_00850 8.7e-206 cotS S Seems to be required for the assembly of the CotSA protein in spores
NHFKFMEO_00851 2.4e-217 cotSA M Glycosyl transferases group 1
NHFKFMEO_00852 3.7e-204 cotI S Spore coat protein
NHFKFMEO_00853 9.9e-77 tspO T membrane
NHFKFMEO_00854 0.0 glgP 2.4.1.1 GT35 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
NHFKFMEO_00855 1.2e-282 glgA 2.4.1.21 GT5 G Synthesizes alpha-1,4-glucan chains using ADP-glucose
NHFKFMEO_00856 2.2e-177 glgD 2.4.1.21, 2.7.7.27 GT5 G Glucose-1-phosphate adenylyltransferase, GlgD subunit
NHFKFMEO_00857 5.2e-196 glgC 2.7.7.27 G Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NHFKFMEO_00858 0.0 glgB 2.4.1.18, 3.2.1.141, 3.2.1.20 CBM48,GH13,GH31 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NHFKFMEO_00860 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
NHFKFMEO_00861 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
NHFKFMEO_00862 2.7e-94 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
NHFKFMEO_00868 3.8e-93 ywrO S Flavodoxin-like fold
NHFKFMEO_00872 1.9e-107 ydeA 1.11.1.6, 3.5.1.124 S DJ-1/PfpI family
NHFKFMEO_00873 2.1e-119 dapA_5 4.3.3.7 EM Dihydrodipicolinate synthetase family
NHFKFMEO_00874 4.9e-155 yeaN P transporter
NHFKFMEO_00875 1.7e-133 cynR K Transcriptional regulator
NHFKFMEO_00876 2.9e-87 S protein conserved in bacteria
NHFKFMEO_00877 1.4e-41 MA20_06410 E threonine efflux protein
NHFKFMEO_00878 0.0 M Domain of unknown function DUF11
NHFKFMEO_00879 6.6e-75 yhcS 3.4.22.70 M COG3764 Sortase (surface protein transpeptidase)
NHFKFMEO_00880 8.5e-75 rimJ2 J Acetyltransferase (GNAT) domain
NHFKFMEO_00881 7.2e-44
NHFKFMEO_00882 2.1e-47 yobL L nucleic acid phosphodiester bond hydrolysis
NHFKFMEO_00883 8.9e-95 M nucleic acid phosphodiester bond hydrolysis
NHFKFMEO_00884 3.4e-33 K Helix-turn-helix XRE-family like proteins
NHFKFMEO_00885 9.6e-40
NHFKFMEO_00886 9.1e-192 des 1.14.19.23, 1.14.19.45 I fatty acid desaturase
NHFKFMEO_00887 8.7e-30 cspL K Cold shock
NHFKFMEO_00888 2.3e-78 carD K Transcription factor
NHFKFMEO_00889 3.5e-139 ydzE EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
NHFKFMEO_00890 6.9e-164 rhaS5 K AraC-like ligand binding domain
NHFKFMEO_00891 2e-169 yicL EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
NHFKFMEO_00892 5.3e-164 ydeE K AraC family transcriptional regulator
NHFKFMEO_00893 6.6e-262 K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
NHFKFMEO_00894 4.2e-218 ydeG EGP Major facilitator superfamily
NHFKFMEO_00895 1e-44 ydeH
NHFKFMEO_00896 3.2e-104 ydeI S Bacteriocin-protection, YdeI or OmpD-Associated
NHFKFMEO_00897 2.4e-92
NHFKFMEO_00898 1.1e-31 S SNARE associated Golgi protein
NHFKFMEO_00899 3.7e-15 ptsH G PTS HPr component phosphorylation site
NHFKFMEO_00900 8.8e-85 K Transcriptional regulator C-terminal region
NHFKFMEO_00902 7.4e-139 ydeK EG -transporter
NHFKFMEO_00903 4.1e-272 ydeL K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
NHFKFMEO_00904 9.3e-74 maoC I N-terminal half of MaoC dehydratase
NHFKFMEO_00905 7.3e-106 ydeN S Serine hydrolase
NHFKFMEO_00906 3e-56 K HxlR-like helix-turn-helix
NHFKFMEO_00907 1.2e-152 yqfU S Uncharacterized protein conserved in bacteria (DUF2179)
NHFKFMEO_00908 4.8e-69 ydeP K Transcriptional regulator
NHFKFMEO_00909 7.9e-108 ydeQ S NADPH-quinone reductase (modulator of drug activity B)
NHFKFMEO_00910 3.6e-192 ydeR EGP Major facilitator Superfamily
NHFKFMEO_00911 1.6e-103 ydeS K Transcriptional regulator
NHFKFMEO_00912 2.8e-57 arsR K transcriptional
NHFKFMEO_00913 1.7e-230 arsB P Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NHFKFMEO_00914 5.2e-147 ydfB J GNAT acetyltransferase
NHFKFMEO_00915 4.2e-156 ydfC EG EamA-like transporter family
NHFKFMEO_00916 6e-274 ydfD K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
NHFKFMEO_00917 1.2e-114 ydfE S Flavin reductase like domain
NHFKFMEO_00918 4.6e-123 ydfF K helix_turn_helix, Arsenical Resistance Operon Repressor
NHFKFMEO_00919 3.8e-78 ydfG S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NHFKFMEO_00921 1e-167 ydfH 2.7.13.3 T Histidine kinase
NHFKFMEO_00922 1.4e-110 ydfI K Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
NHFKFMEO_00923 0.0 ydfJ S drug exporters of the RND superfamily
NHFKFMEO_00924 1.4e-175 S Alpha/beta hydrolase family
NHFKFMEO_00925 1.9e-116 S Protein of unknown function (DUF554)
NHFKFMEO_00926 6e-146 K Bacterial transcription activator, effector binding domain
NHFKFMEO_00927 1.7e-154 fieF P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NHFKFMEO_00928 2.6e-109 ydfN C nitroreductase
NHFKFMEO_00929 4.4e-185 ydfO E COG0346 Lactoylglutathione lyase and related lyases
NHFKFMEO_00930 8.8e-63 mhqP S DoxX
NHFKFMEO_00931 1.7e-54 traF CO Thioredoxin
NHFKFMEO_00932 1.9e-15 ydgA S Spore germination protein gerPA/gerPF
NHFKFMEO_00933 6.3e-29
NHFKFMEO_00935 4.4e-118 ydfR S Protein of unknown function (DUF421)
NHFKFMEO_00936 5.2e-122 ydfS S Protein of unknown function (DUF421)
NHFKFMEO_00937 2.2e-75 cotP O Belongs to the small heat shock protein (HSP20) family
NHFKFMEO_00938 1.4e-37 ydgA S Spore germination protein gerPA/gerPF
NHFKFMEO_00939 1.3e-41 ydgB S Spore germination protein gerPA/gerPF
NHFKFMEO_00940 3e-94 K Bacterial regulatory proteins, tetR family
NHFKFMEO_00941 1.6e-52 S DoxX-like family
NHFKFMEO_00942 2.4e-86 yycN 2.3.1.128 K Acetyltransferase
NHFKFMEO_00943 5.1e-134 1.1.1.18, 1.1.1.369 S Oxidoreductase family, NAD-binding Rossmann fold
NHFKFMEO_00944 2e-119 purR K helix_turn _helix lactose operon repressor
NHFKFMEO_00945 1e-190 csbC EGP Major facilitator Superfamily
NHFKFMEO_00946 4.4e-104 G Xylose isomerase-like TIM barrel
NHFKFMEO_00947 1.7e-301 expZ S ABC transporter
NHFKFMEO_00948 5.2e-251 cycA E COG1113 Gamma-aminobutyrate permease and related permeases
NHFKFMEO_00949 5.1e-90 dinB S DinB family
NHFKFMEO_00950 4.7e-80 K helix_turn_helix multiple antibiotic resistance protein
NHFKFMEO_00951 0.0 ydgH S drug exporters of the RND superfamily
NHFKFMEO_00952 1e-113 drgA C nitroreductase
NHFKFMEO_00953 2.4e-69 ydgJ K Winged helix DNA-binding domain
NHFKFMEO_00954 7.4e-209 tcaB EGP Major facilitator Superfamily
NHFKFMEO_00955 3.5e-121 ydhB S membrane transporter protein
NHFKFMEO_00956 2.5e-121 ydhC K FCD
NHFKFMEO_00957 4.2e-231 ydhD M Glycosyl hydrolase
NHFKFMEO_00958 7e-228 ydhE CG COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase
NHFKFMEO_00959 1.9e-124
NHFKFMEO_00960 2.6e-258 phoB 3.1.3.1 P Belongs to the alkaline phosphatase family
NHFKFMEO_00961 8.7e-68 frataxin S Domain of unknown function (DU1801)
NHFKFMEO_00963 1.5e-80 K Acetyltransferase (GNAT) domain
NHFKFMEO_00964 1e-179 ydhJ S Metal dependent phosphohydrolases with conserved 'HD' motif.
NHFKFMEO_00965 8e-97 ydhK M Protein of unknown function (DUF1541)
NHFKFMEO_00966 2.5e-198 pbuE EGP Major facilitator Superfamily
NHFKFMEO_00967 1.2e-46 ydhM 2.7.1.196, 2.7.1.205 G phosphotransferase system
NHFKFMEO_00968 5.6e-50 ydhN3 2.7.1.196, 2.7.1.205 G phosphotransferase system
NHFKFMEO_00969 7.5e-239 celB G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
NHFKFMEO_00970 4.3e-285 ydhP 3.2.1.21, 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
NHFKFMEO_00971 1.1e-132 ydhQ K UTRA
NHFKFMEO_00972 2.5e-169 gmuE 2.7.1.2, 2.7.1.4 GK COG1940 Transcriptional regulator sugar kinase
NHFKFMEO_00973 8.2e-187 manA 5.3.1.8 G mannose-6-phosphate isomerase
NHFKFMEO_00974 1.5e-213 gmuG 3.2.1.78 GH26 G Belongs to the glycosyl hydrolase 26 family
NHFKFMEO_00975 4.6e-157 ydhU P Catalase
NHFKFMEO_00978 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
NHFKFMEO_00979 3.7e-36 bofA S Sigma-K factor-processing regulatory protein BofA
NHFKFMEO_00980 7.9e-32 yaaL S Protein of unknown function (DUF2508)
NHFKFMEO_00981 3.9e-110 recR L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NHFKFMEO_00982 5.3e-37 yaaK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NHFKFMEO_00983 0.0 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NHFKFMEO_00984 4.3e-83 tadA 3.5.4.1, 3.5.4.3, 3.5.4.33 FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
NHFKFMEO_00985 5e-96 yaaI Q COG1335 Amidases related to nicotinamidase
NHFKFMEO_00986 2.4e-213 yaaH M Glycoside Hydrolase Family
NHFKFMEO_00987 3.6e-114 dgk 2.7.1.113, 2.7.1.74, 2.7.1.76 F Deoxyguanosine kinase
NHFKFMEO_00988 2.2e-122 dck 2.7.1.113, 2.7.1.74, 2.7.1.76 F Deoxycytidine kinase
NHFKFMEO_00989 1.3e-09
NHFKFMEO_00990 4.3e-207 serS 6.1.1.11 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NHFKFMEO_00991 2.3e-107 pdxT 4.3.3.6 H Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
NHFKFMEO_00992 2.2e-157 pdxS 4.3.3.6 H Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
NHFKFMEO_00993 1.2e-247 dacA 3.4.16.4 M Belongs to the peptidase S11 family
NHFKFMEO_00994 1.8e-273 guaB 1.1.1.205 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
NHFKFMEO_00995 1e-181 yaaC S YaaC-like Protein
NHFKFMEO_00996 2.5e-250 srfAA Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
NHFKFMEO_00997 1.8e-92 srfAB Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
NHFKFMEO_00998 3.8e-134 fucR K COG1349 Transcriptional regulators of sugar metabolism
NHFKFMEO_00999 1.5e-272 rhaB 2.7.1.12, 2.7.1.17, 2.7.1.5, 5.3.1.14 G Involved in the catabolism of L-rhamnose (6-deoxy-L- mannose). Catalyzes the transfer of the gamma-phosphate group from ATP to the 1-hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate
NHFKFMEO_01000 1.6e-54 rhaM 5.1.3.32 G Involved in the anomeric conversion of L-rhamnose
NHFKFMEO_01001 7.5e-252 rhaA 2.7.1.5, 5.3.1.14 G Belongs to the rhamnose isomerase family
NHFKFMEO_01002 9.7e-183 ygjR S Oxidoreductase
NHFKFMEO_01003 1.3e-194 yubA S transporter activity
NHFKFMEO_01004 2.7e-133 uppP 3.6.1.27 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
NHFKFMEO_01006 1.3e-87 cdoA 1.13.11.20 S Cysteine dioxygenase type I
NHFKFMEO_01007 5.4e-273 yubD P Major Facilitator Superfamily
NHFKFMEO_01008 6.4e-153 NU Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
NHFKFMEO_01009 1e-38 yiaA S yiaA/B two helix domain
NHFKFMEO_01010 1e-235 ktrB P Potassium
NHFKFMEO_01011 1.9e-121 ktrA P COG0569 K transport systems, NAD-binding component
NHFKFMEO_01012 2.2e-91 yuaB
NHFKFMEO_01013 3.6e-94 yuaC K Belongs to the GbsR family
NHFKFMEO_01014 2.3e-281 gbsA 1.2.1.8 C Belongs to the aldehyde dehydrogenase family
NHFKFMEO_01015 1.1e-228 gbsB 1.1.1.1 C alcohol dehydrogenase
NHFKFMEO_01016 7.4e-106 yuaD
NHFKFMEO_01017 3.9e-84 yuaE S DinB superfamily
NHFKFMEO_01018 4.2e-76 yuaF OU Membrane protein implicated in regulation of membrane protease activity
NHFKFMEO_01019 4.1e-188 yuaG 3.4.21.72 S protein conserved in bacteria
NHFKFMEO_01020 1.4e-92 M1-753 M FR47-like protein
NHFKFMEO_01021 4.3e-90 thiT S Thiamine transporter protein (Thia_YuaJ)
NHFKFMEO_01022 8.7e-249 ybaR P COG0659 Sulfate permease and related transporters (MFS superfamily)
NHFKFMEO_01024 3e-160 ybaS 1.1.1.58 S Na -dependent transporter
NHFKFMEO_01025 7.8e-140 ybbA S Putative esterase
NHFKFMEO_01026 3e-179 feuC P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NHFKFMEO_01027 1.8e-176 feuB P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NHFKFMEO_01028 1.4e-165 feuA P Iron-uptake system-binding protein
NHFKFMEO_01029 5e-306 ybbB K COG2207 AraC-type DNA-binding domain-containing proteins
NHFKFMEO_01030 4.1e-239 ybbC 3.2.1.52 S protein conserved in bacteria
NHFKFMEO_01031 0.0 ybbD 3.2.1.52 G Belongs to the glycosyl hydrolase 3 family
NHFKFMEO_01032 4.2e-225 yfeW 3.4.16.4 V Belongs to the UPF0214 family
NHFKFMEO_01033 1.7e-233 ybbF 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
NHFKFMEO_01034 2.1e-149 ybbH K transcriptional
NHFKFMEO_01035 1.4e-162 murQ 4.2.1.126 G Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NHFKFMEO_01036 1.9e-86 ybbJ J acetyltransferase
NHFKFMEO_01037 1.5e-77 ybbK 2.4.2.1, 6.3.2.4 S Protein of unknown function (DUF523)
NHFKFMEO_01039 1.1e-75 ysnB S Phosphoesterase
NHFKFMEO_01041 9.1e-134 ysnF S protein conserved in bacteria
NHFKFMEO_01042 2.5e-80 ysnE K acetyltransferase
NHFKFMEO_01044 0.0 ilvB 2.2.1.6 E Acetolactate synthase
NHFKFMEO_01045 3.2e-84 ilvN 2.2.1.6 E Acetolactate synthase
NHFKFMEO_01046 9.1e-192 ilvC 1.1.1.86 EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NHFKFMEO_01047 8.4e-290 leuA 2.3.3.13 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NHFKFMEO_01048 1.3e-199 leuB 1.1.1.85 CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
NHFKFMEO_01049 1.7e-276 leuC 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NHFKFMEO_01050 1.8e-115 leuD 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NHFKFMEO_01051 1.9e-186 ysoA H Tetratricopeptide repeat
NHFKFMEO_01052 8.3e-227 tig D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
NHFKFMEO_01053 3.4e-233 clpX O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NHFKFMEO_01054 9.2e-311 lonB 2.7.7.7, 3.4.21.53 LO Belongs to the peptidase S16 family
NHFKFMEO_01055 0.0 lon 3.4.21.53 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NHFKFMEO_01056 1.2e-106 engB D Necessary for normal cell division and for the maintenance of normal septation
NHFKFMEO_01057 1.4e-89 ysxD
NHFKFMEO_01058 3.5e-247 hemA 1.2.1.70 H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NHFKFMEO_01059 3.6e-146 hemX O cytochrome C
NHFKFMEO_01060 9.6e-172 hemC 2.1.1.107, 2.5.1.61, 4.2.1.75 H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
NHFKFMEO_01061 7.1e-144 hemD 2.1.1.107, 4.2.1.75 H Uroporphyrinogen-III synthase
NHFKFMEO_01062 2.8e-182 hemB 4.2.1.24 H Belongs to the ALAD family
NHFKFMEO_01063 1.5e-247 hemL 5.4.3.8 H Glutamate-1-semialdehyde aminotransferase
NHFKFMEO_01064 2.2e-222 spoVID M stage VI sporulation protein D
NHFKFMEO_01065 1.7e-198 ysxE S A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NHFKFMEO_01066 1.6e-25
NHFKFMEO_01067 0.0 valS 6.1.1.9 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
NHFKFMEO_01068 9.6e-247 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
NHFKFMEO_01069 8.3e-126 comC 3.4.23.43 NOU COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases
NHFKFMEO_01070 8.4e-166 spoIIB S Sporulation related domain
NHFKFMEO_01071 2.8e-102 maf D septum formation protein Maf
NHFKFMEO_01072 6.5e-125 radC E Belongs to the UPF0758 family
NHFKFMEO_01073 1.8e-184 mreB D Rod shape-determining protein MreB
NHFKFMEO_01074 2.8e-157 mreC M Involved in formation and maintenance of cell shape
NHFKFMEO_01075 1.4e-84 mreD M shape-determining protein
NHFKFMEO_01076 1.4e-108 minC D Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization
NHFKFMEO_01077 1e-142 minD D Belongs to the ParA family
NHFKFMEO_01078 1.4e-144 spoIVFA M COG0739 Membrane proteins related to metalloendopeptidases
NHFKFMEO_01079 9.2e-161 spoIVFB S Stage IV sporulation protein
NHFKFMEO_01080 5.8e-49 rplU J This protein binds to 23S rRNA in the presence of protein L20
NHFKFMEO_01081 4.1e-56 ysxB J ribosomal protein
NHFKFMEO_01082 2.5e-46 rpmA J Belongs to the bacterial ribosomal protein bL27 family
NHFKFMEO_01083 1.5e-106 spo0B T Sporulation initiation phospho-transferase B, C-terminal
NHFKFMEO_01084 5.6e-231 obg S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NHFKFMEO_01085 2.2e-73 pheB 5.4.99.5 S Belongs to the UPF0735 family
NHFKFMEO_01086 2.2e-162 pheA 4.2.1.51 E Prephenate dehydratase
NHFKFMEO_01087 3.6e-94 niaR S small molecule binding protein (contains 3H domain)
NHFKFMEO_01088 4.5e-227 nifS 2.8.1.7 E Cysteine desulfurase
NHFKFMEO_01089 2.3e-303 nadB 1.3.5.4, 1.4.3.16 H Catalyzes the oxidation of L-aspartate to iminoaspartate
NHFKFMEO_01090 1.9e-158 nadC 1.4.3.16, 2.4.2.19 H Belongs to the NadC ModD family
NHFKFMEO_01091 1.1e-214 nadA 2.5.1.72 H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NHFKFMEO_01092 8.3e-157 safA M spore coat assembly protein SafA
NHFKFMEO_01093 2.2e-49 S Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
NHFKFMEO_01094 1e-125 yebC K transcriptional regulatory protein
NHFKFMEO_01095 4.5e-261 alsT E Sodium alanine symporter
NHFKFMEO_01096 1.3e-50 S Family of unknown function (DUF5412)
NHFKFMEO_01098 6.5e-119 yrzF T serine threonine protein kinase
NHFKFMEO_01099 4.8e-193 iolG 1.1.1.18, 1.1.1.369 S Oxidoreductase family, NAD-binding Rossmann fold
NHFKFMEO_01100 1.3e-251 csbX EGP Major facilitator Superfamily
NHFKFMEO_01101 4.8e-93 bofC S BofC C-terminal domain
NHFKFMEO_01102 3.8e-105 ruvA 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
NHFKFMEO_01103 1.9e-186 ruvB 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
NHFKFMEO_01104 2.6e-18 yrzS S Protein of unknown function (DUF2905)
NHFKFMEO_01105 2e-194 queA 2.4.99.17 J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NHFKFMEO_01106 5.2e-228 tgt 2.4.2.29 F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
NHFKFMEO_01107 1.1e-38 yajC U Preprotein translocase subunit YajC
NHFKFMEO_01108 2.2e-73 yrzE S Protein of unknown function (DUF3792)
NHFKFMEO_01109 3e-111 yrbG S membrane
NHFKFMEO_01110 2.4e-268 spoVB S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
NHFKFMEO_01111 9.4e-49 yrzD S Post-transcriptional regulator
NHFKFMEO_01112 0.0 secF U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NHFKFMEO_01113 1.7e-87 yrvC P regulatory, ligand-binding protein related to C-terminal domains of K channels
NHFKFMEO_01114 3e-48 yrvD S Lipopolysaccharide assembly protein A domain
NHFKFMEO_01115 0.0 recJ L Single-stranded-DNA-specific exonuclease RecJ
NHFKFMEO_01116 5.9e-91 apt 2.4.2.22, 2.4.2.7 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NHFKFMEO_01117 0.0 relA 2.7.6.5 KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NHFKFMEO_01118 2.9e-70 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
NHFKFMEO_01119 1.5e-259 lytH 3.5.1.28 M COG3103 SH3 domain protein
NHFKFMEO_01121 9.8e-244 hisS 6.1.1.21 J histidyl-tRNA synthetase
NHFKFMEO_01122 0.0 aspS 6.1.1.12 J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NHFKFMEO_01123 4e-136 yrvM H COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1
NHFKFMEO_01124 4.4e-236 rarA L COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase
NHFKFMEO_01125 1.2e-70 cymR K Transcriptional regulator
NHFKFMEO_01126 1.4e-212 iscS 2.8.1.7 E Cysteine desulfurase
NHFKFMEO_01127 2.3e-220 mnmA 2.8.1.13 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
NHFKFMEO_01128 1.4e-15 S COG0457 FOG TPR repeat
NHFKFMEO_01129 0.0 recD2 3.1.11.5 L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
NHFKFMEO_01130 1.8e-83 yrrD S protein conserved in bacteria
NHFKFMEO_01131 9.8e-31 yrzR
NHFKFMEO_01132 8e-08 S Protein of unknown function (DUF3918)
NHFKFMEO_01133 7.6e-107 glnP P ABC transporter
NHFKFMEO_01134 8.8e-108 gluC P ABC transporter
NHFKFMEO_01135 1.5e-144 glnH ET Belongs to the bacterial solute-binding protein 3 family
NHFKFMEO_01136 1.3e-131 glnQ 3.6.3.21 E COG1126 ABC-type polar amino acid transport system, ATPase component
NHFKFMEO_01137 2.7e-170 yrrI S AI-2E family transporter
NHFKFMEO_01138 0.0 alaS 6.1.1.7 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NHFKFMEO_01139 1.7e-41 yrzL S Belongs to the UPF0297 family
NHFKFMEO_01140 2.1e-70 yqgF L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NHFKFMEO_01141 1.2e-45 yrzB S Belongs to the UPF0473 family
NHFKFMEO_01142 8.2e-183 mltG S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NHFKFMEO_01143 8.6e-119 yrrM 2.1.1.104 S O-methyltransferase
NHFKFMEO_01144 7.8e-174 yegQ O Peptidase U32
NHFKFMEO_01145 2.7e-246 yegQ O COG0826 Collagenase and related proteases
NHFKFMEO_01146 4.7e-114 udk 2.7.1.48 F Cytidine monophosphokinase
NHFKFMEO_01147 2.4e-78 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
NHFKFMEO_01148 0.0 pbpI 3.4.16.4 M Penicillin-binding Protein
NHFKFMEO_01149 4.2e-63 yrrS S Protein of unknown function (DUF1510)
NHFKFMEO_01150 1e-25 yrzA S Protein of unknown function (DUF2536)
NHFKFMEO_01151 1.2e-120 yrrT 4.4.1.21 Q Could be a S-adenosyl-L-methionine-dependent methyltransferase
NHFKFMEO_01152 4.2e-124 mtnN 3.2.2.9 E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NHFKFMEO_01153 6.1e-171 mccA 2.5.1.134, 2.5.1.47 E Cysteine synthase
NHFKFMEO_01154 9.1e-209 mccB 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
NHFKFMEO_01155 4.6e-35 yrhC S YrhC-like protein
NHFKFMEO_01156 5.4e-78 yrhD S Protein of unknown function (DUF1641)
NHFKFMEO_01157 0.0 fdhA 1.17.1.10, 1.17.1.9 C formate dehydrogenase (NAD+) activity
NHFKFMEO_01158 2.3e-60 yrhF S Uncharacterized conserved protein (DUF2294)
NHFKFMEO_01159 1.8e-142 focA P Formate nitrite
NHFKFMEO_01162 7.2e-95 yrhH Q methyltransferase
NHFKFMEO_01163 8.2e-105 Z012_03230 K Tetracycline repressor, C-terminal all-alpha domain
NHFKFMEO_01164 0.0 cypD 1.14.14.1, 1.6.2.4 C Belongs to the cytochrome P450 family
NHFKFMEO_01165 4.3e-168 capL C PFAM UDP-glucose GDP-mannose dehydrogenase
NHFKFMEO_01166 2.6e-119 wbpP 5.1.3.2, 5.1.3.7 GM NmrA-like family
NHFKFMEO_01167 9.4e-117 S ATPases associated with a variety of cellular activities
NHFKFMEO_01168 5.7e-64 S ABC-2 family transporter protein
NHFKFMEO_01169 8.3e-63 S ABC-2 family transporter protein
NHFKFMEO_01170 7.2e-104 Q TIGRFAM amino acid adenylation domain
NHFKFMEO_01171 2e-46 hopR 1.1.1.31 I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
NHFKFMEO_01172 1.5e-180 hutH 4.3.1.23, 4.3.1.24, 4.3.1.3, 5.4.3.6 E Aromatic amino acid lyase
NHFKFMEO_01173 1.2e-100 EF ATP-grasp domain
NHFKFMEO_01174 6.6e-88 yodQ 3.5.1.16 E Acetylornithine deacetylase
NHFKFMEO_01175 1.5e-52 S dehydrogenases and related proteins
NHFKFMEO_01176 3.9e-11 O Butirosin biosynthesis protein H, N-terminal
NHFKFMEO_01177 7.3e-29 S Butirosin biosynthesis protein H, N-terminal
NHFKFMEO_01178 3.2e-17 yrhK S YrhK-like protein
NHFKFMEO_01179 0.0 yrhL I Acyltransferase family
NHFKFMEO_01180 2.9e-151 rsiV S Protein of unknown function (DUF3298)
NHFKFMEO_01181 1.6e-85 sigV K Belongs to the sigma-70 factor family. ECF subfamily
NHFKFMEO_01182 1.1e-150 yrhO K Archaeal transcriptional regulator TrmB
NHFKFMEO_01183 3.6e-106 yrhP E LysE type translocator
NHFKFMEO_01184 8.7e-254 cycA E COG1113 Gamma-aminobutyrate permease and related permeases
NHFKFMEO_01185 0.0 levR K PTS system fructose IIA component
NHFKFMEO_01186 3.9e-75 levD 2.7.1.202 G PTS system fructose IIA component
NHFKFMEO_01187 2.4e-81 levE 2.7.1.202 G PTS system mannose fructose sorbose family
NHFKFMEO_01188 4.9e-116 manY G COG3715 Phosphotransferase system, mannose fructose N-acetylgalactosamine-specific component IIC
NHFKFMEO_01189 1.5e-152 manZ G COG3716 Phosphotransferase system, mannose fructose N-acetylgalactosamine-specific component IID
NHFKFMEO_01190 0.0 sacC 3.2.1.26, 3.2.1.65, 3.2.1.80 GH32 G Belongs to the glycosyl hydrolase 32 family
NHFKFMEO_01191 5e-90 yhbO 1.11.1.6, 3.5.1.124 S protease
NHFKFMEO_01192 5.4e-104 adhA 1.1.1.1 C alcohol dehydrogenase
NHFKFMEO_01193 5.6e-39 adhA 1.1.1.1 C alcohol dehydrogenase
NHFKFMEO_01194 8.7e-27 yphJ 4.1.1.44 S peroxiredoxin activity
NHFKFMEO_01195 4.3e-47 yraB K helix_turn_helix, mercury resistance
NHFKFMEO_01196 1.1e-47 yraD M Spore coat protein
NHFKFMEO_01197 7.5e-26 yraE
NHFKFMEO_01198 1.2e-221 adhB 1.1.1.1, 1.1.1.14, 1.1.1.284, 1.2.1.46 E COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
NHFKFMEO_01199 6.4e-63 yraF M Spore coat protein
NHFKFMEO_01200 1.5e-36 yraG
NHFKFMEO_01201 3.8e-66 E Glyoxalase-like domain
NHFKFMEO_01202 5.4e-61 T sh3 domain protein
NHFKFMEO_01203 4.9e-60 T sh3 domain protein
NHFKFMEO_01204 6.6e-153 S Alpha beta hydrolase
NHFKFMEO_01205 7.6e-42 yraL S COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
NHFKFMEO_01206 2.7e-157 csn 3.2.1.132 M Aids in the defense against invading fungal pathogens by degrading their cell wall chitosan
NHFKFMEO_01207 5.9e-205 yraM S PrpF protein
NHFKFMEO_01208 3.4e-163 yraN K Transcriptional regulator
NHFKFMEO_01209 3.6e-225 yraO C Citrate transporter
NHFKFMEO_01210 5.5e-186 yrpG C Aldo/keto reductase family
NHFKFMEO_01211 9.1e-95 sigZ K Belongs to the sigma-70 factor family. ECF subfamily
NHFKFMEO_01212 5.4e-117 adcA S ZinT (YodA) periplasmic lipocalin-like zinc-recruitment
NHFKFMEO_01214 4.8e-123 yrpD S Domain of unknown function, YrpD
NHFKFMEO_01215 8.5e-145 murI 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
NHFKFMEO_01216 8.4e-193 yrpB 1.13.12.16 S COG2070 Dioxygenases related to 2-nitropropane dioxygenase
NHFKFMEO_01217 1.2e-165 aadK G Streptomycin adenylyltransferase
NHFKFMEO_01218 6.4e-90 yrdA S DinB family
NHFKFMEO_01220 4e-55 S Protein of unknown function (DUF2568)
NHFKFMEO_01221 1.2e-100 yrdC 3.5.1.19 Q Isochorismatase family
NHFKFMEO_01223 1.9e-23 K Acetyltransferase (GNAT) family
NHFKFMEO_01224 2.9e-229 cypA C Cytochrome P450
NHFKFMEO_01225 4.5e-45 yrdF K ribonuclease inhibitor
NHFKFMEO_01226 2e-77 bkdR K helix_turn_helix ASNC type
NHFKFMEO_01227 9e-136 azlC E AzlC protein
NHFKFMEO_01228 9.6e-50 azlD E Branched-chain amino acid transport protein (AzlD)
NHFKFMEO_01229 3e-227 brnQ E Component of the transport system for branched-chain amino acids
NHFKFMEO_01230 1.2e-160 gltR K LysR substrate binding domain
NHFKFMEO_01231 1.3e-66 yodA S tautomerase
NHFKFMEO_01232 5.1e-149 czcD P COG1230 Co Zn Cd efflux system component
NHFKFMEO_01233 5.6e-197 trkA P Oxidoreductase
NHFKFMEO_01234 3.9e-159 yrdQ K Transcriptional regulator
NHFKFMEO_01235 9.2e-170 yrdR EG EamA-like transporter family
NHFKFMEO_01236 3.9e-16 S YrzO-like protein
NHFKFMEO_01237 4.6e-233 corC1 S COG1253 Hemolysins and related proteins containing CBS domains
NHFKFMEO_01238 5.9e-82 bltD 2.3.1.57 K FR47-like protein
NHFKFMEO_01239 1.3e-210 blt EGP Major facilitator Superfamily
NHFKFMEO_01240 3.4e-149 bltR K helix_turn_helix, mercury resistance
NHFKFMEO_01241 3.8e-107 yrkC G Cupin domain
NHFKFMEO_01242 7.8e-39 yrkD S protein conserved in bacteria
NHFKFMEO_01243 2.8e-82 yrkE O DsrE/DsrF/DrsH-like family
NHFKFMEO_01244 2.3e-96 yrkF OP Belongs to the sulfur carrier protein TusA family
NHFKFMEO_01245 7.1e-206 yrkH P Rhodanese Homology Domain
NHFKFMEO_01246 1.2e-35 yrkI O Belongs to the sulfur carrier protein TusA family
NHFKFMEO_01247 9.3e-112 yrkJ S membrane transporter protein
NHFKFMEO_01248 7e-166 gmuG 3.2.1.78 GH26 G Belongs to the glycosyl hydrolase 26 family
NHFKFMEO_01249 2e-215 mepA V Multidrug transporter MatE
NHFKFMEO_01250 3.6e-112 tetR3 K Transcriptional regulator
NHFKFMEO_01251 1.1e-92 yqaB E IrrE N-terminal-like domain
NHFKFMEO_01253 1.7e-96 adk 2.7.4.3 F adenylate kinase activity
NHFKFMEO_01254 7.9e-89 K Transcriptional regulator PadR-like family
NHFKFMEO_01255 5.4e-158 axeA S Carbohydrate esterase, sialic acid-specific acetylesterase
NHFKFMEO_01258 9.5e-34
NHFKFMEO_01259 4.1e-52 S Protein of unknown function (DUF3800)
NHFKFMEO_01260 1.1e-75 L Transposase
NHFKFMEO_01262 2.1e-42
NHFKFMEO_01265 6.9e-26 yqaS L DNA packaging
NHFKFMEO_01266 3e-43 yqaS L DNA packaging
NHFKFMEO_01267 1.3e-27 S phage terminase, large subunit
NHFKFMEO_01268 4.8e-127 xlyA 3.5.1.28 M N-acetylmuramoyl-L-alanine amidase
NHFKFMEO_01269 2.4e-56 V HNH endonuclease
NHFKFMEO_01270 2.1e-70 yokH G SMI1 / KNR4 family
NHFKFMEO_01271 4.1e-11 S SMI1-KNR4 cell-wall
NHFKFMEO_01272 2.2e-25 S SMI1 / KNR4 family
NHFKFMEO_01273 5.9e-39
NHFKFMEO_01274 1.5e-40
NHFKFMEO_01275 2e-168 yobL S Bacterial EndoU nuclease
NHFKFMEO_01276 3.8e-207 S Aspartate phosphatase response regulator
NHFKFMEO_01278 8.2e-110 nfsA 1.5.1.38, 1.5.1.39 C Nitroreductase family
NHFKFMEO_01279 3.6e-58 K transcriptional
NHFKFMEO_01280 5.8e-108 1.5.1.40 S NADP oxidoreductase coenzyme F420-dependent
NHFKFMEO_01282 4.1e-57 S response regulator aspartate phosphatase
NHFKFMEO_01283 5e-123 yecA E amino acid
NHFKFMEO_01284 7.5e-105 K Transcriptional regulator
NHFKFMEO_01285 2.1e-277 cisA2 L Recombinase
NHFKFMEO_01286 2.4e-219 yfjF U Belongs to the major facilitator superfamily
NHFKFMEO_01287 1.8e-62 napB K helix_turn_helix multiple antibiotic resistance protein
NHFKFMEO_01288 2.8e-56 sigK K sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NHFKFMEO_01289 1.1e-74 nucB M Deoxyribonuclease NucA/NucB
NHFKFMEO_01290 2e-132 yqeB
NHFKFMEO_01291 1.5e-169 gnd 1.1.1.343, 1.1.1.44 G 6-phosphogluconate dehydrogenase
NHFKFMEO_01292 4e-105 yqeD S SNARE associated Golgi protein
NHFKFMEO_01293 3.6e-18 xlyA 3.5.1.28 M n-acetylmuramoyl-L-alanine amidase
NHFKFMEO_01294 1.4e-45 xlyA 3.5.1.28 M n-acetylmuramoyl-L-alanine amidase
NHFKFMEO_01295 6.2e-142 yqeF E GDSL-like Lipase/Acylhydrolase
NHFKFMEO_01297 5.3e-95 yqeG S hydrolase of the HAD superfamily
NHFKFMEO_01298 1.5e-213 yqeH S In Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis
NHFKFMEO_01299 2.7e-157 aroE 1.1.1.25 E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NHFKFMEO_01300 2.1e-45 yhbY J RNA-binding protein containing KH domain, possibly ribosomal protein
NHFKFMEO_01301 2.7e-108 nadD 2.7.7.18, 3.6.1.55 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NHFKFMEO_01302 3.7e-102 nadD 2.7.6.3, 2.7.7.18 H HD superfamily hydrolase involved in NAD metabolism
NHFKFMEO_01303 6.9e-62 rsfS J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
NHFKFMEO_01304 2.1e-137 yqeM Q Methyltransferase
NHFKFMEO_01305 2.5e-147 comER E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NHFKFMEO_01306 6.6e-105 wza L COG1555 DNA uptake protein and related DNA-binding proteins
NHFKFMEO_01307 2.1e-105 comEB 3.5.4.12 F ComE operon protein 2
NHFKFMEO_01308 0.0 comEC S Competence protein ComEC
NHFKFMEO_01309 4.1e-15 S YqzM-like protein
NHFKFMEO_01310 1.3e-188 holA 2.7.7.7 L DNA polymerase III delta subunit
NHFKFMEO_01311 9.7e-37 rpsT J Binds directly to 16S ribosomal RNA
NHFKFMEO_01312 5e-204 gpr 3.4.24.78 C Initiates the rapid degradation of small, acid-soluble proteins during spore germination
NHFKFMEO_01313 1.5e-222 spoIIP M stage II sporulation protein P
NHFKFMEO_01314 4.7e-52 yqxA S Protein of unknown function (DUF3679)
NHFKFMEO_01315 0.0 lepA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
NHFKFMEO_01316 5.9e-216 hemN H Involved in the biosynthesis of porphyrin-containing compound
NHFKFMEO_01317 1.8e-187 hrcA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
NHFKFMEO_01318 1.6e-65 grpE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NHFKFMEO_01319 0.0 dnaK O Heat shock 70 kDa protein
NHFKFMEO_01320 4.2e-182 dnaJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
NHFKFMEO_01321 5.4e-175 prmA J Methylates ribosomal protein L11
NHFKFMEO_01322 1e-139 rsmE 2.1.1.193 J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
NHFKFMEO_01323 6.1e-260 yqeV 2.8.4.5 J ribosomal protein S12 methylthiotransferase
NHFKFMEO_01324 4.1e-157 yqeW P COG1283 Na phosphate symporter
NHFKFMEO_01325 1.2e-19 rpsU J Belongs to the bacterial ribosomal protein bS21 family
NHFKFMEO_01326 2.5e-61 yqeY S Yqey-like protein
NHFKFMEO_01327 7.7e-228 yqeZ O COG1030 Membrane-bound serine protease (ClpP class)
NHFKFMEO_01328 4.3e-122 yqfA S UPF0365 protein
NHFKFMEO_01329 2.4e-21 yqfB
NHFKFMEO_01330 2.7e-45 yqfC S sporulation protein YqfC
NHFKFMEO_01331 1.5e-185 yqfD 3.1.3.102, 3.1.3.104 S Stage IV sporulation
NHFKFMEO_01332 2.5e-175 phoH T Phosphate starvation-inducible protein PhoH
NHFKFMEO_01334 0.0 yqfF S membrane-associated HD superfamily hydrolase
NHFKFMEO_01335 5.1e-81 ybeY 2.6.99.2, 3.5.4.5 S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NHFKFMEO_01336 1.8e-60 dgkA 2.7.1.107, 2.7.1.66 M Diacylglycerol kinase
NHFKFMEO_01337 2.1e-70 cdd 2.4.2.2, 3.5.4.5 F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
NHFKFMEO_01338 3.1e-167 era S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NHFKFMEO_01339 8.4e-19 S YqzL-like protein
NHFKFMEO_01340 8.2e-145 recO L Involved in DNA repair and RecF pathway recombination
NHFKFMEO_01341 9.5e-180 glyQ 6.1.1.14 J glycyl-tRNA synthetase alpha subunit
NHFKFMEO_01342 0.0 glyS 6.1.1.14 J Glycyl-tRNA synthetase beta subunit
NHFKFMEO_01343 4.5e-112 ccpN K CBS domain
NHFKFMEO_01344 5.8e-149 yqfL 2.7.11.33, 2.7.4.28 S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation
NHFKFMEO_01345 4.5e-88 yaiI S Belongs to the UPF0178 family
NHFKFMEO_01346 0.0 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
NHFKFMEO_01347 1.2e-200 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
NHFKFMEO_01348 1.6e-61 cccA C COG2010 Cytochrome c, mono- and diheme variants
NHFKFMEO_01349 6.8e-116 trmK 2.1.1.217 S SAM-dependent methyltransferase
NHFKFMEO_01350 5.3e-209 yqfO 3.5.4.16 S Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NHFKFMEO_01351 4.5e-177 ispH 1.17.7.4, 2.7.4.25 IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NHFKFMEO_01352 3.5e-12 yqfQ S YqfQ-like protein
NHFKFMEO_01353 1.2e-241 cshB 3.6.4.13 JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
NHFKFMEO_01354 2.6e-166 nfo 3.1.21.2 L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
NHFKFMEO_01355 7.9e-36 yqfT S Protein of unknown function (DUF2624)
NHFKFMEO_01356 1.6e-157 yqfU S Uncharacterized protein conserved in bacteria (DUF2179)
NHFKFMEO_01357 1.9e-77 zur P Belongs to the Fur family
NHFKFMEO_01358 1.2e-108 yqfW S Belongs to the 5'(3')-deoxyribonucleotidase family
NHFKFMEO_01359 4.3e-62 yqfX S membrane
NHFKFMEO_01360 2.8e-202 ispG 1.17.7.1, 1.17.7.3 I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NHFKFMEO_01361 5.2e-47 yqfZ M LysM domain
NHFKFMEO_01362 3.9e-131 yqgB S Protein of unknown function (DUF1189)
NHFKFMEO_01363 4e-73 yqgC S protein conserved in bacteria
NHFKFMEO_01364 6.3e-116 sodA 1.15.1.1 P radicals which are normally produced within the cells and which are toxic to biological systems
NHFKFMEO_01365 2.5e-231 yqgE EGP Major facilitator superfamily
NHFKFMEO_01366 0.0 pbpA 3.4.16.4 M penicillin-binding protein
NHFKFMEO_01367 3.4e-150 pstS P Phosphate
NHFKFMEO_01368 3.2e-159 pstC P probably responsible for the translocation of the substrate across the membrane
NHFKFMEO_01369 4.4e-158 pstA P Phosphate transport system permease
NHFKFMEO_01370 3.2e-147 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
NHFKFMEO_01371 8.3e-145 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
NHFKFMEO_01372 2.1e-71 yqzC S YceG-like family
NHFKFMEO_01373 3.5e-50 yqzD
NHFKFMEO_01375 1.5e-41 yqgM 2.4.1.11, 2.4.1.18 GH57,GT4 M Glycosyl transferases group 1
NHFKFMEO_01376 4.1e-133 yqgM 2.4.1.11, 2.4.1.18 GH57,GT4 M Glycosyl transferases group 1
NHFKFMEO_01377 9.4e-21 rpmG J Belongs to the bacterial ribosomal protein bL33 family
NHFKFMEO_01378 2.7e-105 ygfA 6.3.3.2 H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NHFKFMEO_01379 2.5e-09 yqgO
NHFKFMEO_01380 4e-260 gluP 3.4.21.105 O membrane protein (homolog of Drosophila rhomboid)
NHFKFMEO_01381 4.3e-33 yqgQ S Protein conserved in bacteria
NHFKFMEO_01382 5.2e-181 glcK 2.7.1.2 G Glucokinase
NHFKFMEO_01383 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
NHFKFMEO_01384 9.3e-222 yqgT 3.4.19.11 E Gamma-D-glutamyl-L-diamino acid endopeptidase
NHFKFMEO_01385 2.7e-199 yqgU
NHFKFMEO_01386 6.9e-50 yqgV S Thiamine-binding protein
NHFKFMEO_01387 8.9e-23 yqgW S Protein of unknown function (DUF2759)
NHFKFMEO_01388 1.8e-121 ycbL 3.1.2.6 S COG0491 Zn-dependent hydrolases, including glyoxylases
NHFKFMEO_01389 1.8e-37 yqgY S Protein of unknown function (DUF2626)
NHFKFMEO_01390 2.7e-64 yqgZ 1.20.4.1 P Belongs to the ArsC family
NHFKFMEO_01392 7e-150 yqhA T COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
NHFKFMEO_01393 1.3e-238 corC1 S COG1253 Hemolysins and related proteins containing CBS domains
NHFKFMEO_01394 7.2e-175 corA P Mg2 transporter protein
NHFKFMEO_01396 3.9e-201 comGA NU COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NHFKFMEO_01397 5.1e-174 comGB NU COG1459 Type II secretory pathway, component PulF
NHFKFMEO_01398 6.8e-47 comGC U Required for transformation and DNA binding
NHFKFMEO_01399 6.3e-70 gspH NU protein transport across the cell outer membrane
NHFKFMEO_01400 2e-58 comGE
NHFKFMEO_01401 3.5e-45 comGF U Putative Competence protein ComGF
NHFKFMEO_01402 8.8e-44 S ComG operon protein 7
NHFKFMEO_01403 4.4e-25 yqzE S YqzE-like protein
NHFKFMEO_01404 7.3e-54 yqzG S Protein of unknown function (DUF3889)
NHFKFMEO_01405 1.1e-112 yqxM
NHFKFMEO_01406 2.5e-58 sipW 3.4.21.89 U Signal peptidase
NHFKFMEO_01407 5.6e-141 tasA S Cell division protein FtsN
NHFKFMEO_01408 1e-54 sinR K transcriptional
NHFKFMEO_01409 1.2e-24 sinI S Anti-repressor SinI
NHFKFMEO_01410 2.1e-151 yqhG S Bacterial protein YqhG of unknown function
NHFKFMEO_01411 0.0 yqhH L COG0553 Superfamily II DNA RNA helicases, SNF2 family
NHFKFMEO_01412 2.4e-206 gcvT 1.4.4.2, 2.1.2.10 E The glycine cleavage system catalyzes the degradation of glycine
NHFKFMEO_01413 3.2e-253 gcvPA 1.4.4.2 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NHFKFMEO_01414 5.3e-286 gcvPB 1.4.4.2 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NHFKFMEO_01415 2.3e-63 yqhL P COG0607 Rhodanese-related sulfurtransferase
NHFKFMEO_01416 2.6e-160 lipM 6.3.1.20 H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation
NHFKFMEO_01417 9.4e-74 mntR K Involved in manganese homeostasis. Might activate the transcription of the mntABCD operon
NHFKFMEO_01418 8.1e-165 yqhO S esterase of the alpha-beta hydrolase superfamily
NHFKFMEO_01419 2.2e-61 yqhP
NHFKFMEO_01420 2.3e-173 yqhQ S Protein of unknown function (DUF1385)
NHFKFMEO_01421 2.3e-93 yqhR S Conserved membrane protein YqhR
NHFKFMEO_01422 9.4e-77 aroQ 4.2.1.10 E Catalyzes a trans-dehydration via an enolate intermediate
NHFKFMEO_01423 1.3e-172 yqhT 3.4.11.9, 3.4.13.9 E COG0006 Xaa-Pro aminopeptidase
NHFKFMEO_01424 5.4e-98 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NHFKFMEO_01425 7.9e-37 yqhV S Protein of unknown function (DUF2619)
NHFKFMEO_01426 3e-170 spoIIIAA S stage III sporulation protein AA
NHFKFMEO_01427 1.1e-84 spoIIIAB S Stage III sporulation protein
NHFKFMEO_01428 7.6e-29 spoIIIAC S stage III sporulation protein AC
NHFKFMEO_01429 2.3e-58 spoIIIAD S Stage III sporulation protein AD
NHFKFMEO_01430 1.3e-197 spoIIIAE S stage III sporulation protein AE
NHFKFMEO_01431 1.2e-101 spoIIIAF S Stage III sporulation protein AF (Spore_III_AF)
NHFKFMEO_01432 2.2e-109 spoIIIAG S stage III sporulation protein AG
NHFKFMEO_01433 9.9e-91 spoIIIAH S SpoIIIAH-like protein
NHFKFMEO_01434 1.5e-64 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
NHFKFMEO_01435 3.4e-255 accC 6.3.4.14, 6.4.1.2 I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
NHFKFMEO_01436 2.1e-67 yqhY S protein conserved in bacteria
NHFKFMEO_01437 1.9e-65 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NHFKFMEO_01438 6.7e-156 folD 1.5.1.5, 3.5.4.9 F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NHFKFMEO_01439 1.1e-245 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
NHFKFMEO_01440 5.8e-39 xseB 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
NHFKFMEO_01441 7.7e-163 ispA 2.5.1.1, 2.5.1.10, 2.5.1.29, 2.5.1.90 H Belongs to the FPP GGPP synthase family
NHFKFMEO_01442 0.0 dxs 2.2.1.7 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NHFKFMEO_01443 6.6e-156 rrmJ 2.1.1.226, 2.1.1.227 J rRNA methylase
NHFKFMEO_01444 1.7e-78 argR K Regulates arginine biosynthesis genes
NHFKFMEO_01445 0.0 recN L May be involved in recombinational repair of damaged DNA
NHFKFMEO_01446 1.2e-238 rseP 3.4.21.116 M Stage IV sporulation protein B
NHFKFMEO_01447 3.2e-144 KT May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process
NHFKFMEO_01449 4e-212 yqiG C COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family
NHFKFMEO_01450 6e-27
NHFKFMEO_01451 5.4e-107 amiC 3.5.1.28 M Cell wall hydrolase autolysin
NHFKFMEO_01452 8.9e-133 yqiK 3.1.4.46 C glycerophosphoryl diester phosphodiesterase
NHFKFMEO_01453 5.9e-219 mmgA 2.3.1.9 I Belongs to the thiolase family
NHFKFMEO_01454 2.3e-156 hbdA 1.1.1.157 I Dehydrogenase
NHFKFMEO_01455 8.8e-212 mmgC I acyl-CoA dehydrogenase
NHFKFMEO_01456 8.4e-207 prpC 2.3.3.1, 2.3.3.5 C Belongs to the citrate synthase family
NHFKFMEO_01457 2.4e-275 prpD 4.2.1.79 S 2-methylcitrate dehydratase
NHFKFMEO_01458 6.9e-159 prpB 4.1.3.30 G Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NHFKFMEO_01459 4e-34 yqzF S Protein of unknown function (DUF2627)
NHFKFMEO_01460 0.0 bkdR 2.7.13.3 KT Transcriptional regulator
NHFKFMEO_01461 2.3e-154 pta 2.3.1.19, 2.3.1.8 C phosphate butyryltransferase
NHFKFMEO_01462 1.1e-206 ldh 1.4.1.9 E Belongs to the Glu Leu Phe Val dehydrogenases family
NHFKFMEO_01463 1.2e-202 buk 2.7.2.7 C Belongs to the acetokinase family
NHFKFMEO_01464 2.8e-268 lpdA 1.8.1.4 C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
NHFKFMEO_01465 1.9e-186 bfmBAA 1.2.4.4 C COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
NHFKFMEO_01466 1.8e-184 bfmBAB 1.2.4.1, 1.2.4.4 C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
NHFKFMEO_01467 5.4e-226 bfmBB 2.3.1.168, 2.3.1.61 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
NHFKFMEO_01468 6.4e-151 bmrR K helix_turn_helix, mercury resistance
NHFKFMEO_01469 5.1e-207 norA EGP Major facilitator Superfamily
NHFKFMEO_01470 9.8e-166 yegS 2.7.1.107 I COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
NHFKFMEO_01471 9.3e-77 yqiW S Belongs to the UPF0403 family
NHFKFMEO_01472 6.3e-137 artP ET Belongs to the bacterial solute-binding protein 3 family
NHFKFMEO_01473 6.2e-109 artQ E COG0765 ABC-type amino acid transport system, permease component
NHFKFMEO_01474 7.7e-129 artM 3.6.3.21 E COG1126 ABC-type polar amino acid transport system, ATPase component
NHFKFMEO_01475 4.4e-172 yqjA S Putative aromatic acid exporter C-terminal domain
NHFKFMEO_01476 3e-98 yqjB S protein conserved in bacteria
NHFKFMEO_01478 2.2e-75 mce 4.4.1.5, 5.1.99.1, 5.4.99.2 E COG0346 Lactoylglutathione lyase and related lyases
NHFKFMEO_01479 1.8e-289 mmdA 2.1.3.15, 6.4.1.3 I COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
NHFKFMEO_01480 2.8e-202 yqjE 3.4.11.4 E COG2195 Di- and tripeptidases
NHFKFMEO_01481 7e-138 yqjF S Uncharacterized conserved protein (COG2071)
NHFKFMEO_01482 5.7e-144 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
NHFKFMEO_01483 4.5e-24 yqzJ
NHFKFMEO_01484 1.6e-235 dinB 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NHFKFMEO_01485 6.9e-267 gnd 1.1.1.343, 1.1.1.44 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NHFKFMEO_01486 2.6e-288 zwf 1.1.1.363, 1.1.1.49 G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NHFKFMEO_01487 2.9e-173 rnz 3.1.26.11 S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
NHFKFMEO_01488 3e-19 rpmG J Belongs to the bacterial ribosomal protein bL33 family
NHFKFMEO_01489 3.6e-145 yqjL S hydrolases or acyltransferases (alpha beta hydrolase superfamily)
NHFKFMEO_01490 1.4e-192 namA 1.6.99.1 C Catalyzes the reduction of the double bond of an array of alpha,beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes
NHFKFMEO_01491 0.0 rocB E arginine degradation protein
NHFKFMEO_01492 5.6e-147 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NHFKFMEO_01493 1.2e-177 yqjP S COG0491 Zn-dependent hydrolases, including glyoxylases
NHFKFMEO_01494 1.7e-142 yqjQ S Belongs to the short-chain dehydrogenases reductases (SDR) family
NHFKFMEO_01495 5.4e-261 dsdA 4.3.1.18 E Belongs to the serine threonine dehydratase family. DsdA subfamily
NHFKFMEO_01496 2.4e-178 coaA 2.7.1.33 F Pantothenic acid kinase
NHFKFMEO_01497 7.2e-73 yqjT 3.1.26.4 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
NHFKFMEO_01499 7e-223 yqjV G Major Facilitator Superfamily
NHFKFMEO_01501 6e-238 polYB 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NHFKFMEO_01502 1.1e-48 S YolD-like protein
NHFKFMEO_01503 1.8e-86 yqjY K acetyltransferase
NHFKFMEO_01504 7e-56 yqjZ 2.3.1.128, 2.5.1.18 S enzyme involved in biosynthesis of extracellular polysaccharides
NHFKFMEO_01505 4.4e-194 yqkA K GrpB protein
NHFKFMEO_01506 2.8e-54 yqkB S Belongs to the HesB IscA family
NHFKFMEO_01507 9.4e-39 yqkC S Protein of unknown function (DUF2552)
NHFKFMEO_01508 4.2e-172 yqkD S COG1073 Hydrolases of the alpha beta superfamily
NHFKFMEO_01509 3.1e-12 yqkE S Protein of unknown function (DUF3886)
NHFKFMEO_01510 5.3e-167 yqkF C oxidoreductases (related to aryl-alcohol dehydrogenases)
NHFKFMEO_01512 2.6e-92 nudF 3.6.1.13 L Belongs to the Nudix hydrolase family
NHFKFMEO_01513 1.9e-217 yqxK 3.6.4.12 L DNA helicase
NHFKFMEO_01514 1.3e-57 ansR K Transcriptional regulator
NHFKFMEO_01515 8e-185 ansA 3.5.1.1 EJ L-asparaginase
NHFKFMEO_01516 4.9e-268 aspA 4.2.1.2, 4.3.1.1 E Aspartate ammonia-lyase
NHFKFMEO_01517 3.1e-235 mleN C Na H antiporter
NHFKFMEO_01518 1.2e-241 mleA 1.1.1.38 C malic enzyme
NHFKFMEO_01519 5.5e-30 yqkK
NHFKFMEO_01520 2.3e-108 spoIIM S Required for complete septum migration and engulfment of the forespore compartment during sporulation. Required for stabilizing and recruiting of SpoIIP to the septal membrane
NHFKFMEO_01521 2.4e-80 fur P Belongs to the Fur family
NHFKFMEO_01522 1.4e-36 S Protein of unknown function (DUF4227)
NHFKFMEO_01523 2.6e-166 xerD L recombinase XerD
NHFKFMEO_01524 3e-231 deoB 5.4.2.7 G Phosphotransfer between the C1 and C5 carbon atoms of pentose
NHFKFMEO_01525 6.4e-148 punA 2.4.2.1 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NHFKFMEO_01526 2.4e-212 dacF 3.4.16.4 M Belongs to the peptidase S11 family
NHFKFMEO_01527 3.9e-57 spoIIAA T Belongs to the anti-sigma-factor antagonist family
NHFKFMEO_01528 1.8e-75 spoIIAB 2.7.11.1 F Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition
NHFKFMEO_01529 2.4e-136 sigF K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NHFKFMEO_01530 2.1e-111 spoVAA S Stage V sporulation protein AA
NHFKFMEO_01531 1e-67 spoVAB S Stage V sporulation protein AB
NHFKFMEO_01532 1.5e-77 spoVAC S stage V sporulation protein AC
NHFKFMEO_01533 9e-192 spoVAD I Stage V sporulation protein AD
NHFKFMEO_01534 2.2e-57 spoVAEB S stage V sporulation protein
NHFKFMEO_01535 1.4e-110 spoVAEA S stage V sporulation protein
NHFKFMEO_01536 1.4e-273 spoVAF EG Stage V sporulation protein AF
NHFKFMEO_01537 5.2e-256 lysA 4.1.1.19, 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
NHFKFMEO_01538 8.1e-149 ypuA S Secreted protein
NHFKFMEO_01539 8e-81 ppiB 5.2.1.8 O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NHFKFMEO_01542 7.3e-17 S SNARE associated Golgi protein
NHFKFMEO_01543 2.3e-33 yhcC S nucleic-acid-binding protein containing a Zn-ribbon domain
NHFKFMEO_01544 6.2e-94 sipT 3.4.21.89 U Belongs to the peptidase S26 family
NHFKFMEO_01545 7.8e-55 ypuD
NHFKFMEO_01546 4.9e-204 ribD 1.1.1.193, 3.5.4.26 H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NHFKFMEO_01547 3.3e-115 ribE 2.5.1.9 H Riboflavin synthase
NHFKFMEO_01548 2.9e-229 ribBA 3.5.4.25, 4.1.99.12 H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NHFKFMEO_01549 1.5e-80 ribH 2.5.1.78 H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
NHFKFMEO_01550 4.5e-64 ribT K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
NHFKFMEO_01551 3.2e-92 ypuF S Domain of unknown function (DUF309)
NHFKFMEO_01552 2.2e-129 scpA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NHFKFMEO_01553 1.9e-104 scpB D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NHFKFMEO_01554 7.6e-97 ypuI S Protein of unknown function (DUF3907)
NHFKFMEO_01555 4.7e-213 dacB 3.4.16.4 M Belongs to the peptidase S11 family
NHFKFMEO_01556 3.5e-103 spmA S Spore maturation protein
NHFKFMEO_01557 1.9e-87 spmB S Spore maturation protein
NHFKFMEO_01558 6.9e-133 rluB 5.4.99.19, 5.4.99.21, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
NHFKFMEO_01559 1.3e-99 resA CO Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c
NHFKFMEO_01560 0.0 ccs1 O COG1333 ResB protein required for cytochrome c biosynthesis
NHFKFMEO_01561 3.9e-215 ccsA O 'COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component'
NHFKFMEO_01562 6.7e-133 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
NHFKFMEO_01563 0.0 resE 2.7.13.3 T Histidine kinase
NHFKFMEO_01564 2.6e-103 sigX K Belongs to the sigma-70 factor family. ECF subfamily
NHFKFMEO_01565 6.3e-199 rsiX
NHFKFMEO_01566 1.8e-131 aroD 1.1.1.25, 4.2.1.10 E Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
NHFKFMEO_01567 1.5e-294 serA 1.1.1.399, 1.1.1.95 E Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NHFKFMEO_01568 5.8e-87 fmnP U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
NHFKFMEO_01569 4.7e-41 fer C Ferredoxin
NHFKFMEO_01570 5.1e-198 ypbB 5.1.3.1 S protein conserved in bacteria
NHFKFMEO_01571 9.2e-286 recQ 3.6.4.12 L DNA helicase
NHFKFMEO_01572 1.1e-99 ypbD S metal-dependent membrane protease
NHFKFMEO_01573 1.7e-78 ypbE M Lysin motif
NHFKFMEO_01574 3.7e-81 ypbF S Protein of unknown function (DUF2663)
NHFKFMEO_01575 6.8e-147 ypbG S Calcineurin-like phosphoesterase superfamily domain
NHFKFMEO_01576 2.4e-104 mecB NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC
NHFKFMEO_01577 2.6e-244 gudB 1.4.1.2, 1.4.1.3 E Belongs to the Glu Leu Phe Val dehydrogenases family
NHFKFMEO_01578 1.3e-174 ypdA 1.18.1.2, 1.19.1.1, 1.8.1.9 O COG0492 Thioredoxin reductase
NHFKFMEO_01579 2.3e-119 prsW S Involved in the degradation of specific anti-sigma factors
NHFKFMEO_01580 3.3e-153 sleB 3.5.1.28 M Spore cortex-lytic enzyme
NHFKFMEO_01581 6.5e-254 hemX 2.1.1.107, 4.2.1.75 H sporulation protein
NHFKFMEO_01582 1.2e-112 ypfA M Flagellar protein YcgR
NHFKFMEO_01583 1.8e-23 S Family of unknown function (DUF5359)
NHFKFMEO_01584 6.1e-112 cmk 1.17.7.4, 2.5.1.19, 2.7.1.26, 2.7.4.25, 2.7.7.2, 6.3.2.1 F Belongs to the cytidylate kinase family. Type 1 subfamily
NHFKFMEO_01585 1.6e-205 rpsA 1.17.7.4 J Ribosomal protein S1
NHFKFMEO_01586 7.9e-183 fni 1.1.1.88, 5.3.3.2 C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
NHFKFMEO_01587 1e-07 S YpzI-like protein
NHFKFMEO_01588 3.9e-102 yphA
NHFKFMEO_01589 2.5e-161 seaA S YIEGIA protein
NHFKFMEO_01590 7.9e-28 ypzH
NHFKFMEO_01591 6.7e-248 der 1.1.1.399, 1.1.1.95 S GTPase that plays an essential role in the late steps of ribosome biogenesis
NHFKFMEO_01592 5.1e-190 gpsA 1.1.1.94 I Glycerol-3-phosphate dehydrogenase
NHFKFMEO_01593 1.6e-18 yphE S Protein of unknown function (DUF2768)
NHFKFMEO_01594 6e-137 yphF
NHFKFMEO_01595 3.7e-279 spoIVA S ATPase. Has a role at an early stage in the morphogenesis of the spore coat
NHFKFMEO_01596 4.7e-42 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
NHFKFMEO_01597 7.1e-101 folE 3.5.4.16 H GTP cyclohydrolase
NHFKFMEO_01598 2.3e-34 mtrB K Required for transcription attenuation control in the Trp operon. This trans-acting factor seems to recognize a 10 bases nucleotide sequence in the Trp leader transcript causing transcription termination. Binds the leader RNA only in presence of L-tryptophan
NHFKFMEO_01599 2.8e-137 hepS 2.5.1.30 H Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1
NHFKFMEO_01600 8.6e-133 menG 2.1.1.163, 2.1.1.201 H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)
NHFKFMEO_01601 2.9e-193 hepT 2.5.1.30, 2.5.1.83, 2.5.1.90 H Belongs to the FPP GGPP synthase family
NHFKFMEO_01602 9.1e-80 ndk 2.7.4.6 F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
NHFKFMEO_01603 1.1e-141 cheR 2.1.1.80 NT COG1352 Methylase of chemotaxis methyl-accepting proteins
NHFKFMEO_01604 5.5e-217 aroC 4.2.3.5 E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NHFKFMEO_01605 3.8e-204 aroB 2.7.1.71, 4.2.3.4 E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NHFKFMEO_01606 1e-63 aroH 2.7.4.25, 5.4.99.5 E Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis
NHFKFMEO_01607 1.1e-292 trpE 4.1.3.27 EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NHFKFMEO_01608 1.2e-180 trpD 2.4.2.18, 4.1.3.27 E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NHFKFMEO_01609 4.7e-113 trpC 4.1.1.48, 5.3.1.24 E Belongs to the TrpC family
NHFKFMEO_01610 3.3e-115 trpF 4.1.1.48, 4.2.1.160, 4.2.1.20, 5.3.1.24 E Belongs to the TrpF family
NHFKFMEO_01611 5.8e-230 trpB 4.2.1.20, 5.3.1.24 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
NHFKFMEO_01612 1.2e-143 trpA 4.2.1.20 E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
NHFKFMEO_01613 4.2e-203 hisC 2.6.1.9 E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NHFKFMEO_01614 2.2e-207 tyrA 1.3.1.12, 1.3.1.43 E prephenate dehydrogenase
NHFKFMEO_01615 3.4e-236 aroA 1.3.1.12, 1.3.1.43, 2.5.1.19 E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
NHFKFMEO_01616 8.5e-232 S COG0457 FOG TPR repeat
NHFKFMEO_01617 2.8e-99 ypiB S Belongs to the UPF0302 family
NHFKFMEO_01618 1.9e-77 ypiF S Protein of unknown function (DUF2487)
NHFKFMEO_01619 9.3e-97 qcrA C Menaquinol-cytochrome c reductase
NHFKFMEO_01620 5.2e-127 petB C COG1290 Cytochrome b subunit of the bc complex
NHFKFMEO_01621 4.3e-146 qcrC C Menaquinol-cytochrome c reductase cytochrome b c subunit
NHFKFMEO_01622 7.6e-98 ypjA S membrane
NHFKFMEO_01623 1e-142 ypjB S sporulation protein
NHFKFMEO_01624 5.2e-156 ypjC S Uncharacterized protein conserved in bacteria (DUF2179)
NHFKFMEO_01625 3.1e-56 ypjD 2.5.1.19 S Nucleotide pyrophosphohydrolase
NHFKFMEO_01626 1.8e-147 dapB 1.17.1.8 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
NHFKFMEO_01627 7.2e-71 mgsA 2.7.1.24, 4.2.3.3 G methylglyoxal synthase
NHFKFMEO_01628 1.7e-128 bshB1 S proteins, LmbE homologs
NHFKFMEO_01629 6.9e-209 bshA GT4 M N-acetyl-alpha-D-glucosaminyl L-malate synthase
NHFKFMEO_01630 5e-218 cca 2.7.7.19, 2.7.7.72 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
NHFKFMEO_01631 8.7e-184 birA 6.3.4.15 K Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
NHFKFMEO_01632 1.4e-150 panB 2.1.2.11 H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
NHFKFMEO_01633 6.1e-157 panC 2.7.4.25, 6.3.2.1 H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NHFKFMEO_01634 3.5e-64 panD 4.1.1.11 H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NHFKFMEO_01635 0.0 dinG 2.7.7.7, 3.6.4.12 L helicase involved in DNA repair and perhaps also replication
NHFKFMEO_01636 1.9e-22 ypmA S Protein of unknown function (DUF4264)
NHFKFMEO_01637 4.9e-79 ypmB S protein conserved in bacteria
NHFKFMEO_01638 1.5e-222 aspB 2.6.1.1, 2.6.1.14 E Aminotransferase
NHFKFMEO_01639 5.8e-252 asnS 6.1.1.22 J asparaginyl-tRNA
NHFKFMEO_01640 1.3e-128 dnaD L DNA replication protein DnaD
NHFKFMEO_01641 2.2e-122 nth 4.2.99.18 L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NHFKFMEO_01642 1.8e-92 ypoC
NHFKFMEO_01643 0.0 ponA 2.4.1.129, 2.7.7.7, 3.4.16.4 GT51 M penicillin-binding protein
NHFKFMEO_01644 1.2e-114 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
NHFKFMEO_01645 5.4e-186 yppC S Protein of unknown function (DUF2515)
NHFKFMEO_01648 2e-11 yppE S Bacterial domain of unknown function (DUF1798)
NHFKFMEO_01650 6.6e-47 yppG S YppG-like protein
NHFKFMEO_01651 1.9e-71 hspX O Belongs to the small heat shock protein (HSP20) family
NHFKFMEO_01652 1e-80 ypqE 2.7.1.199 G COG2190 Phosphotransferase system IIA components
NHFKFMEO_01653 0.0 yprA L COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster
NHFKFMEO_01654 2.5e-236 yprB L RNase_H superfamily
NHFKFMEO_01655 8.2e-91 ypsA S Belongs to the UPF0398 family
NHFKFMEO_01656 2.8e-45 gpsB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
NHFKFMEO_01657 1.2e-224 rlmL 2.1.1.173, 2.1.1.264 L Belongs to the methyltransferase superfamily
NHFKFMEO_01659 0.0 ypvA 3.6.4.12 KL COG1199 Rad3-related DNA helicases
NHFKFMEO_01660 5.7e-130 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
NHFKFMEO_01661 1.1e-158 kduI 5.3.1.17 G Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
NHFKFMEO_01662 7.4e-186 ptxS K transcriptional
NHFKFMEO_01663 1.1e-186 kdgK 2.7.1.45 G COG0524 Sugar kinases, ribokinase family
NHFKFMEO_01664 4.6e-103 eda 2.7.1.45, 4.1.2.14, 4.1.3.42 G 2-dehydro-3-deoxy-phosphogluconate aldolase
NHFKFMEO_01665 1.9e-170 kdgT P The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system
NHFKFMEO_01666 3.9e-292 ypwA 3.4.17.19 E Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
NHFKFMEO_01667 4.4e-98 xpt 2.4.2.22, 2.4.2.7 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
NHFKFMEO_01668 3.8e-227 pbuX F xanthine
NHFKFMEO_01669 8.2e-207 bcsA Q Naringenin-chalcone synthase
NHFKFMEO_01670 7.4e-86 ypbQ S protein conserved in bacteria
NHFKFMEO_01672 0.0 ypbR S Dynamin family
NHFKFMEO_01673 8.5e-38 ypbS S Protein of unknown function (DUF2533)
NHFKFMEO_01674 2e-07
NHFKFMEO_01675 1.5e-166 polA 2.7.7.7 L 5'3' exonuclease
NHFKFMEO_01677 8.5e-69 rnhA 3.1.26.4 L Ribonuclease
NHFKFMEO_01678 4.5e-106 ypdP S Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
NHFKFMEO_01679 6.4e-125 ypeP 3.1.26.4 L COG0328 Ribonuclease HI
NHFKFMEO_01680 3e-29 ypeQ S Zinc-finger
NHFKFMEO_01681 1.8e-30 S Protein of unknown function (DUF2564)
NHFKFMEO_01682 3.8e-16 degR
NHFKFMEO_01683 7.9e-31 cspD K Cold-shock protein
NHFKFMEO_01684 5.9e-216 ugtP 2.4.1.315 GT28 M Processive glucosyltransferase involved in the biosynthesis of both the bilayer- and non-bilayer-forming membrane glucolipids. Is able to successively transfer up to three glucosyl residues to diacylglycerol (DAG), thereby catalyzing the formation of beta-monoglucosyl-DAG (3-O-(beta-D-glucopyranosyl)-1,2-diacyl- sn-glycerol), beta-diglucosyl-DAG (3-O-(beta-D-glucopyranosyl- beta-(1- 6)-D-glucopyranosyl)-1,2-diacyl-sn-glycerol) and beta- triglucosyl-DAG (3-O-(beta-D-glucopyranosyl-beta-(1- 6)-D- glucopyranosyl-beta-(1- 6)-D-glucopyranosyl)-1,2-diacyl-sn- glycerol). Beta-diglucosyl-DAG is the predominant glycolipid found in Bacillales and is also used as a membrane anchor for lipoteichoic acid (LTA)
NHFKFMEO_01685 7.3e-177 metAA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NHFKFMEO_01686 1.1e-86 btuE 1.11.1.9 O Belongs to the glutathione peroxidase family
NHFKFMEO_01687 3.9e-105 ypgQ S phosphohydrolase
NHFKFMEO_01688 5.8e-155 ypgR C COG0694 Thioredoxin-like proteins and domains
NHFKFMEO_01689 0.0 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
NHFKFMEO_01690 1.7e-75 yphP S Belongs to the UPF0403 family
NHFKFMEO_01691 1.3e-145 ypiP 2.1.1.242 AJ Putative SAM-dependent methyltransferase
NHFKFMEO_01692 7.8e-114 ypjP S YpjP-like protein
NHFKFMEO_01693 3.3e-92 pgpA 3.1.3.27 I COG1267 Phosphatidylglycerophosphatase A and related proteins
NHFKFMEO_01694 4.8e-156 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NHFKFMEO_01695 5.1e-95 folA 1.1.1.262, 1.5.1.3 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NHFKFMEO_01696 7.4e-112 ypkP 2.3.1.51 I Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family
NHFKFMEO_01697 4.2e-110 hlyIII S protein, Hemolysin III
NHFKFMEO_01698 6.1e-185 pspF K Transcriptional regulator
NHFKFMEO_01699 4.4e-244 ilvA 4.3.1.19 E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NHFKFMEO_01700 3.1e-40 ypmP S Protein of unknown function (DUF2535)
NHFKFMEO_01701 1.2e-108 ypmQ S protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems
NHFKFMEO_01702 1.1e-136 ypmR E GDSL-like Lipase/Acylhydrolase
NHFKFMEO_01703 5e-99 ypmS S protein conserved in bacteria
NHFKFMEO_01704 5.5e-29 ypmT S Uncharacterized ympT
NHFKFMEO_01705 9.3e-221 mepA V MATE efflux family protein
NHFKFMEO_01706 1.6e-70 ypoP K transcriptional
NHFKFMEO_01707 3.5e-102 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NHFKFMEO_01708 1.3e-78 msrB 1.8.4.11, 1.8.4.12 O peptide methionine sulfoxide reductase
NHFKFMEO_01709 5.6e-125 4.2.1.115 GM Polysaccharide biosynthesis protein
NHFKFMEO_01710 1.2e-211 phy 3.1.3.8 I Myo-inositol-hexaphosphate 3-phosphohydrolase
NHFKFMEO_01711 4.2e-183 cgeB S Spore maturation protein
NHFKFMEO_01712 3.3e-65 cgeA
NHFKFMEO_01713 3.5e-38 cgeC
NHFKFMEO_01714 1.9e-255 cgeD M maturation of the outermost layer of the spore
NHFKFMEO_01715 1.6e-143 yiiD K acetyltransferase
NHFKFMEO_01717 2.3e-248 yodT H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NHFKFMEO_01718 6.5e-125 yodS 2.8.3.8, 2.8.3.9 I COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NHFKFMEO_01719 8e-117 scoB 2.8.3.5, 2.8.3.8, 2.8.3.9 I COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit
NHFKFMEO_01720 1.4e-258 yodQ 3.5.1.16 E Acetylornithine deacetylase
NHFKFMEO_01721 6.7e-153 yodP 2.3.1.264 K Acetyltransferase (GNAT) family
NHFKFMEO_01722 9.7e-277 kamA 5.4.3.2 E lysine 2,3-aminomutase
NHFKFMEO_01723 2.9e-47 yokU S YokU-like protein, putative antitoxin
NHFKFMEO_01724 1.4e-36 yozE S Belongs to the UPF0346 family
NHFKFMEO_01725 1.6e-123 yodN
NHFKFMEO_01727 2.8e-24 yozD S YozD-like protein
NHFKFMEO_01728 1.7e-105 yodM 3.6.1.27 I Acid phosphatase homologues
NHFKFMEO_01729 3.6e-54 yodL S YodL-like
NHFKFMEO_01730 5.3e-09
NHFKFMEO_01731 4.1e-127 deoD 2.4.2.1, 2.4.2.28 F Purine nucleoside phosphorylase
NHFKFMEO_01732 5.5e-139 vanY 3.4.17.14 M D-alanyl-D-alanine carboxypeptidase
NHFKFMEO_01733 5.2e-24 yodI
NHFKFMEO_01734 1.1e-127 yodH Q Methyltransferase
NHFKFMEO_01735 1.8e-251 ctpA 3.4.21.102 M Belongs to the peptidase S41A family
NHFKFMEO_01736 1.9e-267 yodF E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NHFKFMEO_01737 1.1e-27 S Protein of unknown function (DUF3311)
NHFKFMEO_01738 1.1e-172 yodE E COG0346 Lactoylglutathione lyase and related lyases
NHFKFMEO_01739 3.8e-113 mhqD S Carboxylesterase
NHFKFMEO_01740 1.4e-107 yodC C nitroreductase
NHFKFMEO_01741 6.6e-54 yodB K transcriptional
NHFKFMEO_01742 2.3e-63 yodA S tautomerase
NHFKFMEO_01743 5e-206 gntP EG COG2610 H gluconate symporter and related permeases
NHFKFMEO_01744 3.4e-09
NHFKFMEO_01745 1.5e-64 yozR S COG0071 Molecular chaperone (small heat shock protein)
NHFKFMEO_01746 9.5e-161 rarD S -transporter
NHFKFMEO_01747 1.5e-43
NHFKFMEO_01748 2.2e-60 yojF S Protein of unknown function (DUF1806)
NHFKFMEO_01749 3.7e-125 yojG S deacetylase
NHFKFMEO_01750 5.5e-150 T COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
NHFKFMEO_01751 1.6e-244 norM V Multidrug efflux pump
NHFKFMEO_01753 1.2e-109 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NHFKFMEO_01754 1.8e-231 yojK CG UDP-glucoronosyl and UDP-glucosyl transferase
NHFKFMEO_01755 1.6e-198 sle1 3.5.1.28 CBM50 M COG1388 FOG LysM repeat
NHFKFMEO_01756 6.6e-110 sodC 1.15.1.1 P Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NHFKFMEO_01757 1.1e-161 yojN S ATPase family associated with various cellular activities (AAA)
NHFKFMEO_01758 0.0 yojO P Von Willebrand factor
NHFKFMEO_01759 0.0 sucA 1.2.4.2, 4.1.1.71 C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)
NHFKFMEO_01760 5.3e-194 sucB 2.3.1.61 C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)
NHFKFMEO_01761 5.1e-168 yocS S -transporter
NHFKFMEO_01762 7.9e-228 yocR S Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
NHFKFMEO_01763 2.1e-165 sodA 1.15.1.1 P Superoxide dismutase
NHFKFMEO_01764 0.0 sqhC 4.2.1.137, 5.4.99.7 I COG1657 Squalene cyclase
NHFKFMEO_01765 5.2e-289 dhaS 1.2.1.3, 1.2.1.39 C Belongs to the aldehyde dehydrogenase family
NHFKFMEO_01766 2.7e-31 yozC
NHFKFMEO_01767 4.2e-56 yozO S Bacterial PH domain
NHFKFMEO_01768 1.9e-36 yocN
NHFKFMEO_01769 1.1e-40 yozN
NHFKFMEO_01770 1.3e-87 yocM O Belongs to the small heat shock protein (HSP20) family
NHFKFMEO_01771 6.2e-32
NHFKFMEO_01772 6.4e-54 yocL
NHFKFMEO_01773 3.3e-83 dksA T general stress protein
NHFKFMEO_01774 7.9e-114 azoR I Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NHFKFMEO_01775 0.0 recQ 3.6.4.12 L DNA helicase
NHFKFMEO_01776 7.1e-113 yocH CBM50 M COG1388 FOG LysM repeat
NHFKFMEO_01777 1e-105 desR T COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
NHFKFMEO_01778 1.1e-195 desK 2.7.13.3 T Histidine kinase
NHFKFMEO_01779 4.1e-203 des 1.14.19.23, 1.14.19.45 I fatty acid desaturase
NHFKFMEO_01780 1.5e-188 yocD 3.4.17.13 V peptidase S66
NHFKFMEO_01781 1.2e-93 yocC
NHFKFMEO_01782 1.3e-142
NHFKFMEO_01783 1.5e-92 yozB S membrane
NHFKFMEO_01784 4.4e-118 pvaA M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)
NHFKFMEO_01785 1e-51 czrA K transcriptional
NHFKFMEO_01786 1.8e-90 yobW
NHFKFMEO_01787 6.2e-171 yobV K WYL domain
NHFKFMEO_01788 8.3e-87 yobU K Bacterial transcription activator, effector binding domain
NHFKFMEO_01789 2.8e-131 yobT S COG0491 Zn-dependent hydrolases, including glyoxylases
NHFKFMEO_01790 1.3e-97 yobS K Transcriptional regulator
NHFKFMEO_01791 5.3e-141 yobR 2.3.1.1 J FR47-like protein
NHFKFMEO_01792 3.8e-136 yobQ K helix_turn_helix, arabinose operon control protein
NHFKFMEO_01793 9.3e-53 csaA 6.1.1.10, 6.1.1.20, 6.1.1.6 J tRNA-binding protein
NHFKFMEO_01794 0.0 yobO M Pectate lyase superfamily protein
NHFKFMEO_01795 8.3e-276 iaaM 1.4.3.4 E COG1231 Monoamine oxidase
NHFKFMEO_01796 9.1e-101 yokH G SMI1 / KNR4 family
NHFKFMEO_01797 0.0 L A nuclease of the HNH/ENDO VII superfamily with conserved LHH
NHFKFMEO_01798 2.8e-84 S SMI1-KNR4 cell-wall
NHFKFMEO_01800 2.9e-272 kdpA 3.6.3.12 P Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NHFKFMEO_01801 0.0 kdpB 3.6.3.12 P Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
NHFKFMEO_01802 1.2e-63 kdpC 3.6.3.12 P Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
NHFKFMEO_01803 2.7e-176 T PhoQ Sensor
NHFKFMEO_01805 3.2e-45
NHFKFMEO_01807 4e-121 xlnB 3.2.1.8 G Glycosyl hydrolases family 11
NHFKFMEO_01808 0.0 pps 2.7.9.2 GT phosphoenolpyruvate synthase
NHFKFMEO_01811 3.8e-165 bla 3.5.2.6 V beta-lactamase
NHFKFMEO_01812 4.3e-115 yoaZ 1.11.1.6, 3.5.1.124 S DJ-1/PfpI family
NHFKFMEO_01813 1.8e-77 yoaW
NHFKFMEO_01814 1.5e-158 yijE EG EamA-like transporter family
NHFKFMEO_01815 8.6e-159 yoaU K LysR substrate binding domain
NHFKFMEO_01816 5.3e-147 yoaT S Protein of unknown function (DUF817)
NHFKFMEO_01817 4.4e-30 yozG K Transcriptional regulator
NHFKFMEO_01818 2.8e-74 yoaS S Protein of unknown function (DUF2975)
NHFKFMEO_01819 9.3e-172 yoaR V vancomycin resistance protein
NHFKFMEO_01820 7.3e-86
NHFKFMEO_01823 7.9e-232 oxdC 4.1.1.2 G Oxalate decarboxylase
NHFKFMEO_01826 3.5e-131 yoqW S Belongs to the SOS response-associated peptidase family
NHFKFMEO_01827 2.5e-197 pelB 4.2.2.10, 4.2.2.2 G Amb_all
NHFKFMEO_01828 5.2e-111 yoaK S Membrane
NHFKFMEO_01829 6.5e-133 yoaJ G Endoglucanase C-terminal domain subunit and related proteins
NHFKFMEO_01830 8.7e-281 hpaB 1.14.14.9 Q COG2368 Aromatic ring hydroxylase
NHFKFMEO_01831 3.5e-180 mcpU NT methyl-accepting chemotaxis protein
NHFKFMEO_01832 1.5e-38 S Protein of unknown function (DUF4025)
NHFKFMEO_01833 2.2e-07
NHFKFMEO_01834 3.3e-90 purR K Transcriptional regulator
NHFKFMEO_01835 3.2e-151 iolE 4.2.1.44 G Xylose isomerase-like TIM barrel
NHFKFMEO_01836 1.6e-205 S Oxidoreductase family, C-terminal alpha/beta domain
NHFKFMEO_01837 3e-172 iolT EGP Major facilitator Superfamily
NHFKFMEO_01838 6.6e-32 yoaF
NHFKFMEO_01839 0.0 yoaE C belongs to the prokaryotic molybdopterin-containing oxidoreductase family
NHFKFMEO_01840 4.4e-183 yoaD 1.1.1.399, 1.1.1.95 EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NHFKFMEO_01841 5.3e-278 yoaC 2.7.1.12, 2.7.1.17, 2.7.1.189, 2.7.1.5 G FGGY family of carbohydrate kinases, C-terminal domain
NHFKFMEO_01842 1.2e-233 yoaB EGP Major facilitator Superfamily
NHFKFMEO_01843 8.6e-80 hpr K helix_turn_helix multiple antibiotic resistance protein
NHFKFMEO_01844 1.8e-138 V AAA domain, putative AbiEii toxin, Type IV TA system
NHFKFMEO_01845 2.9e-94 V ABC-2 family transporter protein
NHFKFMEO_01846 3.8e-126 V ABC-2 family transporter protein
NHFKFMEO_01847 5.6e-92 yoaA 2.3.1.128 J COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
NHFKFMEO_01848 2.5e-130 yoxB
NHFKFMEO_01849 7e-39 yoxC S Bacterial protein of unknown function (DUF948)
NHFKFMEO_01850 7.7e-121 fabG 1.1.1.100 S Belongs to the short-chain dehydrogenases reductases (SDR) family
NHFKFMEO_01851 2e-59 rtp K Plays a role in DNA replication and termination (fork arrest mechanism). Two dimers of rtp bind to the two inverted repeat regions (IRI and IRII) present in the termination site. The binding of each dimer is centered on an 8 bp direct repeat
NHFKFMEO_01852 2.5e-144 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NHFKFMEO_01853 9.2e-206 proB 2.7.2.11 E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NHFKFMEO_01854 3.9e-154 gltC K Transcriptional regulator
NHFKFMEO_01855 0.0 gltB 1.4.1.13, 1.4.1.14, 1.4.7.1 E glutamate synthase
NHFKFMEO_01856 2.9e-292 gltD 1.4.1.13, 1.4.1.14 E COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases
NHFKFMEO_01857 6.1e-185 yogA C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases
NHFKFMEO_01858 4.7e-157 gltR1 K Transcriptional regulator
NHFKFMEO_01859 0.0 ggt 2.3.2.2, 3.4.19.13 E gamma-glutamyltransferase
NHFKFMEO_01860 3e-34 yoeD G Helix-turn-helix domain
NHFKFMEO_01861 2.2e-96 L Integrase
NHFKFMEO_01863 2.6e-97 yoeB S IseA DL-endopeptidase inhibitor
NHFKFMEO_01864 2.3e-246 yoeA V MATE efflux family protein
NHFKFMEO_01865 5.6e-191 yoxA 5.1.3.3 G Aldose 1-epimerase
NHFKFMEO_01866 1.4e-273 dacC 3.4.16.4 M D-alanyl-D-alanine carboxypeptidase
NHFKFMEO_01867 9.1e-95 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
NHFKFMEO_01868 3.8e-287 lysS 6.1.1.6 J Belongs to the class-II aminoacyl-tRNA synthetase family
NHFKFMEO_01869 8.3e-190 dus J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NHFKFMEO_01870 4.1e-30 yazB K transcriptional
NHFKFMEO_01871 1.8e-87 folK 1.13.11.81, 2.5.1.15, 2.7.6.3, 3.5.4.16, 4.1.2.25, 5.1.99.8 H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NHFKFMEO_01872 5.9e-61 folB 1.13.11.81, 2.5.1.15, 2.7.6.3, 4.1.2.25, 5.1.99.8 H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NHFKFMEO_01873 2.6e-160 folP 2.5.1.15, 2.7.6.3 H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NHFKFMEO_01874 1.6e-168 pabC 2.6.1.42, 4.1.3.38 EH 4-amino-4-deoxychorismate lyase
NHFKFMEO_01875 4.3e-106 pabA 2.6.1.85, 4.1.3.27 EH Anthranilate synthase
NHFKFMEO_01876 2.2e-268 pabB 2.6.1.85 EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NHFKFMEO_01877 5.7e-169 cysK 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
NHFKFMEO_01878 6.8e-159 yacD 5.2.1.8 O peptidyl-prolyl isomerase
NHFKFMEO_01879 2.9e-162 hslO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NHFKFMEO_01880 1.5e-146 coaX 2.7.1.33 F Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NHFKFMEO_01881 0.0 ftsH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NHFKFMEO_01882 7.9e-94 hpt 2.4.2.8, 6.3.4.19 F Belongs to the purine pyrimidine phosphoribosyltransferase family
NHFKFMEO_01883 4.7e-271 tilS 2.4.2.8, 6.3.4.19 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
NHFKFMEO_01884 1.4e-184 KLT serine threonine protein kinase
NHFKFMEO_01885 1.5e-124 yabS S protein containing a von Willebrand factor type A (vWA) domain
NHFKFMEO_01886 0.0 spoIIE 3.1.3.16, 3.1.3.3 KT stage II sporulation protein E
NHFKFMEO_01889 8.5e-58 yabR J RNA binding protein (contains ribosomal protein S1 domain)
NHFKFMEO_01890 1.1e-44 divIC D Septum formation initiator
NHFKFMEO_01891 2.5e-107 yabQ S spore cortex biosynthesis protein
NHFKFMEO_01892 1.5e-49 yabP S Sporulation protein YabP
NHFKFMEO_01893 1.1e-37 yabO J COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
NHFKFMEO_01894 3e-244 mazG 3.6.1.66, 3.6.1.9 S COG3956 Protein containing tetrapyrrole methyltransferase domain and MazG-like
NHFKFMEO_01895 2.1e-283 yabM S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
NHFKFMEO_01896 1.5e-92 spoVT K stage V sporulation protein
NHFKFMEO_01897 0.0 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NHFKFMEO_01898 2.4e-39 yabK S Peptide ABC transporter permease
NHFKFMEO_01899 8e-105 pth 3.1.1.29 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
NHFKFMEO_01900 3.9e-97 ctc J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NHFKFMEO_01901 9.4e-175 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NHFKFMEO_01902 6.6e-230 glmU 2.3.1.157, 2.7.7.23 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NHFKFMEO_01903 4.6e-48 spoVG D Essential for sporulation. Interferes with or is a negative regulator of the pathway leading to asymmetric septation
NHFKFMEO_01904 3.8e-63 yabJ 3.5.99.10 J translation initiation inhibitor, yjgF family
NHFKFMEO_01905 2.6e-152 purR 2.4.2.22, 2.4.2.7 F pur operon repressor
NHFKFMEO_01906 4.1e-161 ispE 2.1.1.182, 2.7.1.148 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NHFKFMEO_01907 7.8e-39 veg S protein conserved in bacteria
NHFKFMEO_01908 1.6e-136 yabG S peptidase
NHFKFMEO_01909 1.5e-155 ksgA 2.1.1.182 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
NHFKFMEO_01910 3.5e-97 rnmV 3.1.26.8 J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
NHFKFMEO_01911 9.9e-167 rpfB GH23 T protein conserved in bacteria
NHFKFMEO_01912 1.2e-143 tatD L hydrolase, TatD
NHFKFMEO_01913 0.0 metG 6.1.1.10, 6.1.1.20 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NHFKFMEO_01914 8.8e-44 abrB K COG2002 Regulators of stationary sporulation gene expression
NHFKFMEO_01915 4.6e-152 rsmI 2.1.1.198 H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NHFKFMEO_01916 1.4e-44 yazA L endonuclease containing a URI domain
NHFKFMEO_01917 2.5e-138 yabB 2.1.1.223 S Conserved hypothetical protein 95
NHFKFMEO_01918 4.8e-31 yabA L Involved in initiation control of chromosome replication
NHFKFMEO_01919 6.1e-146 yaaT S stage 0 sporulation protein
NHFKFMEO_01920 1.1e-181 holB 2.7.7.7 L DNA polymerase III
NHFKFMEO_01921 1.5e-71 yaaR S protein conserved in bacteria
NHFKFMEO_01922 2.2e-54 yaaQ S protein conserved in bacteria
NHFKFMEO_01923 2e-112 tmk 2.7.4.9 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NHFKFMEO_01924 8.7e-273 adiA 4.1.1.17, 4.1.1.18, 4.1.1.19 E Orn Lys Arg decarboxylase
NHFKFMEO_01925 1.2e-200 yaaN P Belongs to the TelA family
NHFKFMEO_01926 2.6e-101 xpaC S 5-bromo-4-chloroindolyl phosphate hydrolysis protein
NHFKFMEO_01927 1.7e-30 csfB S Inhibitor of sigma-G Gin
NHFKFMEO_01929 1.3e-179 thiL 2.7.4.16 H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NHFKFMEO_01930 1.2e-85 ydiB 2.7.1.221, 5.1.1.1 S ATPase or kinase
NHFKFMEO_01931 9e-127 yeaZ 2.3.1.234 O COG1214 Inactive homolog of metal-dependent proteases
NHFKFMEO_01932 1.3e-84 rimI 2.3.1.128 K This enzyme acetylates the N-terminal alanine of ribosomal protein S18
NHFKFMEO_01933 1.4e-187 tsaD 2.3.1.234 O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NHFKFMEO_01934 0.0 ydiF S ABC transporter
NHFKFMEO_01935 5.5e-89 moaC 4.6.1.17 H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)
NHFKFMEO_01936 8.8e-116 rex K Modulates transcription in response to changes in cellular NADH NAD( ) redox state
NHFKFMEO_01937 7.5e-22 tatA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
NHFKFMEO_01938 1.1e-125 tatC U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NHFKFMEO_01939 2.9e-27 ydiK S Domain of unknown function (DUF4305)
NHFKFMEO_01940 7.9e-129 ydiL S CAAX protease self-immunity
NHFKFMEO_01941 1.3e-42 groS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NHFKFMEO_01942 1.2e-278 groL O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
NHFKFMEO_01943 0.0 hsdR 3.1.21.3 L Type III restriction protein res subunit
NHFKFMEO_01944 7.3e-259 hsdM 2.1.1.72 V type I restriction-modification system
NHFKFMEO_01945 6.2e-149 hsdS 3.1.21.3 V PFAM restriction modification system DNA specificity domain
NHFKFMEO_01946 1.4e-102 2.7.7.7 L Domain of unknown function (DUF4357)
NHFKFMEO_01947 6.7e-204 K NB-ARC domain
NHFKFMEO_01948 3.8e-235 K NB-ARC domain
NHFKFMEO_01949 1.2e-199 gutB 1.1.1.14 E Dehydrogenase
NHFKFMEO_01950 2.1e-252 gutA G MFS/sugar transport protein
NHFKFMEO_01951 5.2e-173 ydjE 2.7.1.4 G pfkB family carbohydrate kinase
NHFKFMEO_01952 8.7e-114 pspA KT Phage shock protein A
NHFKFMEO_01953 3.4e-178 ydjG 3.6.4.12 L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NHFKFMEO_01954 1.2e-132 ydjH S COG1512 Beta-propeller domains of methanol dehydrogenase type
NHFKFMEO_01955 1.8e-149 ydjI S virion core protein (lumpy skin disease virus)
NHFKFMEO_01956 2.3e-195 S Ion transport 2 domain protein
NHFKFMEO_01957 5e-257 iolT EGP Major facilitator Superfamily
NHFKFMEO_01958 5.2e-195 bdhA 1.1.1.303, 1.1.1.4 E Dehydrogenase
NHFKFMEO_01959 4.5e-64 ydjM M Lytic transglycolase
NHFKFMEO_01960 3.6e-151 ydjN U Involved in the tonB-independent uptake of proteins
NHFKFMEO_01962 1.4e-34 ydjO S Cold-inducible protein YdjO
NHFKFMEO_01963 7.6e-157 ydjP I Alpha/beta hydrolase family
NHFKFMEO_01964 3.1e-173 yeaA S Protein of unknown function (DUF4003)
NHFKFMEO_01965 0.0 cotA 1.10.3.4, 1.16.3.3 Q multicopper oxidases
NHFKFMEO_01966 7.5e-253 gabP E COG1113 Gamma-aminobutyrate permease and related permeases
NHFKFMEO_01967 3.8e-154 yeaB P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NHFKFMEO_01968 2.7e-177 yeaC S COG0714 MoxR-like ATPases
NHFKFMEO_01969 2.3e-223 yeaD S conserved protein (some members contain a von Willebrand factor type A (vWA) domain)
NHFKFMEO_01970 0.0 yebA E COG1305 Transglutaminase-like enzymes
NHFKFMEO_01971 8.3e-306 guaA 2.3.1.128, 6.3.5.2 F Catalyzes the synthesis of GMP from XMP
NHFKFMEO_01972 6.4e-88 K Belongs to the sigma-70 factor family. ECF subfamily
NHFKFMEO_01973 1e-244 S Domain of unknown function (DUF4179)
NHFKFMEO_01974 1.5e-210 pbuG S permease
NHFKFMEO_01975 8.3e-116 yebC M Membrane
NHFKFMEO_01977 8.9e-93 yebE S UPF0316 protein
NHFKFMEO_01978 8e-28 yebG S NETI protein
NHFKFMEO_01979 1.3e-82 purE 5.4.99.18 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NHFKFMEO_01980 7e-217 purK 6.3.4.18 F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NHFKFMEO_01981 2.8e-246 purB 4.3.2.2 F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NHFKFMEO_01982 4.9e-131 purC 4.1.1.21, 4.3.2.2, 6.3.2.6 F Belongs to the SAICAR synthetase family
NHFKFMEO_01983 2.9e-38 purS 6.3.2.6, 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NHFKFMEO_01984 3.3e-129 purQ 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NHFKFMEO_01985 0.0 purL 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NHFKFMEO_01986 1.2e-271 purF 2.4.2.14 F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NHFKFMEO_01987 3.8e-177 purM 6.3.3.1, 6.3.4.13 F Phosphoribosylformylglycinamidine cyclo-ligase
NHFKFMEO_01988 8.3e-105 purN 2.1.2.2 F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NHFKFMEO_01989 6e-288 purH 2.1.2.3, 3.5.4.10 F Bifunctional purine biosynthesis protein PurH
NHFKFMEO_01990 1.7e-232 purD 6.3.4.13 F Belongs to the GARS family
NHFKFMEO_01991 8.2e-70 K helix_turn_helix ASNC type
NHFKFMEO_01992 6.1e-230 yjeH E Amino acid permease
NHFKFMEO_01993 1.1e-28 S Protein of unknown function (DUF2892)
NHFKFMEO_01994 0.0 yerA 3.5.4.2 F adenine deaminase
NHFKFMEO_01995 8.3e-190 yerB S Protein of unknown function (DUF3048) C-terminal domain
NHFKFMEO_01996 4.8e-51 yerC S protein conserved in bacteria
NHFKFMEO_01997 3.9e-303 yerD 1.4.7.1 E Belongs to the glutamate synthase family
NHFKFMEO_01998 3.8e-125 pcrB I 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
NHFKFMEO_01999 0.0 pcrA 3.6.4.12 L ATP-dependent DNA helicase
NHFKFMEO_02000 0.0 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NHFKFMEO_02001 7e-220 camS S COG4851 Protein involved in sex pheromone biosynthesis
NHFKFMEO_02003 6e-196 yerI S homoserine kinase type II (protein kinase fold)
NHFKFMEO_02004 1.6e-123 sapB S MgtC SapB transporter
NHFKFMEO_02005 2e-264 putP E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NHFKFMEO_02006 2.1e-45 gatC 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NHFKFMEO_02007 1.2e-274 gatA 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
NHFKFMEO_02008 3.1e-270 gatB 6.1.1.12, 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NHFKFMEO_02009 4.6e-149 yerO K Transcriptional regulator
NHFKFMEO_02010 0.0 swrC V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NHFKFMEO_02011 3e-170 yegS 2.7.1.107 I COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
NHFKFMEO_02012 1.6e-255 rumA 2.1.1.190 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NHFKFMEO_02013 0.0 L Type III restriction enzyme res subunit
NHFKFMEO_02015 5.8e-43
NHFKFMEO_02017 1.4e-100 S response regulator aspartate phosphatase
NHFKFMEO_02019 2.7e-27
NHFKFMEO_02020 4.2e-75 S Protein of unknown function, DUF600
NHFKFMEO_02021 0.0 L nucleic acid phosphodiester bond hydrolysis
NHFKFMEO_02023 1.5e-100 L endonuclease activity
NHFKFMEO_02024 1e-171 3.4.24.40 CO amine dehydrogenase activity
NHFKFMEO_02025 1.5e-211 S Tetratricopeptide repeat
NHFKFMEO_02027 2.7e-126 yeeN K transcriptional regulatory protein
NHFKFMEO_02029 9.4e-101 dhaR3 K Transcriptional regulator
NHFKFMEO_02030 5.4e-80 yesE S SnoaL-like domain
NHFKFMEO_02031 2.8e-146 yesF GM NAD(P)H-binding
NHFKFMEO_02032 5.3e-45 cotJA S Spore coat associated protein JA (CotJA)
NHFKFMEO_02033 1.5e-45 cotJB S CotJB protein
NHFKFMEO_02034 5.2e-104 cotJC P Spore Coat
NHFKFMEO_02035 6e-102 yesJ K Acetyltransferase (GNAT) family
NHFKFMEO_02037 5.9e-101 yesL S Protein of unknown function, DUF624
NHFKFMEO_02038 0.0 yesM 2.7.13.3 T Histidine kinase
NHFKFMEO_02039 2.1e-202 yesN K helix_turn_helix, arabinose operon control protein
NHFKFMEO_02040 2.8e-246 yesO G Bacterial extracellular solute-binding protein
NHFKFMEO_02041 2.8e-171 yesP G Binding-protein-dependent transport system inner membrane component
NHFKFMEO_02042 2.4e-164 yesQ P Binding-protein-dependent transport system inner membrane component
NHFKFMEO_02043 2.9e-198 3.2.1.172 GH105 S Glycosyl Hydrolase Family 88
NHFKFMEO_02044 0.0 yesS K Transcriptional regulator
NHFKFMEO_02045 3e-130 E GDSL-like Lipase/Acylhydrolase
NHFKFMEO_02046 1.2e-128 yesU S Domain of unknown function (DUF1961)
NHFKFMEO_02047 1.3e-111 yesV S Protein of unknown function, DUF624
NHFKFMEO_02048 0.0 yesX 4.2.2.23, 4.2.2.24 PL11 E cell wall organization
NHFKFMEO_02049 0.0 yesX 4.2.2.23, 4.2.2.24 PL11 E cell wall organization
NHFKFMEO_02050 1.5e-123 yesY E GDSL-like Lipase/Acylhydrolase
NHFKFMEO_02051 0.0 yesZ 3.2.1.23 G beta-galactosidase activity
NHFKFMEO_02052 0.0 yetA
NHFKFMEO_02053 9.6e-291 lplA G Bacterial extracellular solute-binding protein
NHFKFMEO_02054 3.2e-175 lplB G COG4209 ABC-type polysaccharide transport system, permease component
NHFKFMEO_02055 1.7e-162 lplC G Binding-protein-dependent transport system inner membrane component
NHFKFMEO_02056 9.3e-253 lplD 3.2.1.122, 3.2.1.22, 3.2.1.86 GH4,GT4 G Family 4 glycosyl hydrolase
NHFKFMEO_02057 4.4e-121 yetF S membrane
NHFKFMEO_02058 4.4e-55 isdI 1.14.99.48, 1.14.99.57 S Antibiotic biosynthesis monooxygenase
NHFKFMEO_02059 7.4e-64 yetH E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
NHFKFMEO_02060 2e-34
NHFKFMEO_02061 5.4e-145 T COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
NHFKFMEO_02062 1.2e-19 yezD S Uncharacterized small protein (DUF2292)
NHFKFMEO_02063 5.3e-105 yetJ S Belongs to the BI1 family
NHFKFMEO_02064 1.4e-14 yetM CH FAD binding domain
NHFKFMEO_02065 1.8e-198 yetN S Protein of unknown function (DUF3900)
NHFKFMEO_02066 0.0 cypD 1.14.14.1, 1.6.2.4 C Belongs to the cytochrome P450 family
NHFKFMEO_02067 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
NHFKFMEO_02068 1e-147 rfbF 2.7.7.33 JM Nucleotidyl transferase
NHFKFMEO_02069 2.1e-171 yfnG 4.2.1.45 M dehydratase
NHFKFMEO_02070 3.2e-180 yfnF M Nucleotide-diphospho-sugar transferase
NHFKFMEO_02071 1.2e-224 yfnE 2.4.1.338 GT2 S Glycosyltransferase like family 2
NHFKFMEO_02072 6.2e-187 yfnD M Nucleotide-diphospho-sugar transferase
NHFKFMEO_02073 4.6e-206 fsr P COG0477 Permeases of the major facilitator superfamily
NHFKFMEO_02074 3.9e-133 yjjG 3.1.3.102, 3.1.3.104, 3.1.3.5, 3.8.1.2 S Haloacid dehalogenase-like hydrolase
NHFKFMEO_02075 1.4e-240 yfnA E amino acid
NHFKFMEO_02076 1.1e-278 yfmT 1.2.1.3, 1.2.1.67 C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
NHFKFMEO_02077 1.1e-113 yfmS NT chemotaxis protein
NHFKFMEO_02078 0.0 yfmR S COG0488 ATPase components of ABC transporters with duplicated ATPase domains
NHFKFMEO_02079 3.7e-73 yfmQ S Uncharacterised protein from bacillus cereus group
NHFKFMEO_02080 9e-69 yfmP K transcriptional
NHFKFMEO_02081 1.9e-209 yfmO EGP Major facilitator Superfamily
NHFKFMEO_02082 7.1e-297 yfmM S COG0488 ATPase components of ABC transporters with duplicated ATPase domains
NHFKFMEO_02083 2.9e-199 yfmL 3.6.4.13 L COG0513 Superfamily II DNA and RNA helicases
NHFKFMEO_02084 3.1e-80 yfmK 2.3.1.128 K acetyltransferase
NHFKFMEO_02085 3e-187 yfmJ S N-terminal domain of oxidoreductase
NHFKFMEO_02086 1.1e-149 yfmF 3.6.3.34 P ATPases associated with a variety of cellular activities
NHFKFMEO_02087 8.1e-169 fecD P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NHFKFMEO_02088 4.7e-169 viuD P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NHFKFMEO_02089 3.4e-169 fecB P COG4594 ABC-type Fe3 -citrate transport system, periplasmic component
NHFKFMEO_02090 5e-24 S Protein of unknown function (DUF3212)
NHFKFMEO_02091 7.6e-58 yflT S Heat induced stress protein YflT
NHFKFMEO_02092 3.8e-240 pel 4.2.2.10, 4.2.2.2 G Pectate lyase
NHFKFMEO_02093 5.5e-235 yflS P Sodium:sulfate symporter transmembrane region
NHFKFMEO_02094 7.5e-289 citS 2.7.13.3 T Signal transduction histidine kinase regulating citrate malate metabolism
NHFKFMEO_02095 2.2e-117 citT T response regulator
NHFKFMEO_02096 3.1e-178 yflP S Tripartite tricarboxylate transporter family receptor
NHFKFMEO_02097 1.9e-226 citM C Citrate transporter
NHFKFMEO_02098 2.1e-151 yflN S COG0491 Zn-dependent hydrolases, including glyoxylases
NHFKFMEO_02099 8.7e-217 nos 1.14.14.47 C Belongs to the NOS family. Bacterial NOS oxygenase subfamily
NHFKFMEO_02100 1.1e-43 acyP 3.6.1.7 C Belongs to the acylphosphatase family
NHFKFMEO_02101 6.4e-122 yflK S protein conserved in bacteria
NHFKFMEO_02102 1.2e-17 yflJ S Protein of unknown function (DUF2639)
NHFKFMEO_02103 4.1e-19 yflI
NHFKFMEO_02104 5.3e-50 yflH S Protein of unknown function (DUF3243)
NHFKFMEO_02105 1.1e-138 map 3.4.11.18 E Methionine aminopeptidase
NHFKFMEO_02106 1.1e-250 nagE 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G COG1263 Phosphotransferase system IIC components, glucose maltose N-acetylglucosamine-specific
NHFKFMEO_02107 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
NHFKFMEO_02108 6e-67 yhdN S Domain of unknown function (DUF1992)
NHFKFMEO_02109 4.9e-252 agcS_1 E Sodium alanine symporter
NHFKFMEO_02110 3.5e-13 yfkQ EG Spore germination protein
NHFKFMEO_02111 8.5e-257 treP 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
NHFKFMEO_02112 0.0 treC 3.2.1.93 GH13 G COG0366 Glycosidases
NHFKFMEO_02113 1.8e-133 treR K transcriptional
NHFKFMEO_02114 1.1e-124 yfkO C nitroreductase
NHFKFMEO_02115 2e-176 cpdB 3.1.3.5, 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
NHFKFMEO_02116 0.0 cpdB 3.1.3.5, 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
NHFKFMEO_02117 3.6e-88 yfkM 1.11.1.6, 3.5.1.124 S protease
NHFKFMEO_02118 1.5e-206 ydiM EGP Major facilitator Superfamily
NHFKFMEO_02119 2.1e-29 yfkK S Belongs to the UPF0435 family
NHFKFMEO_02120 3e-81 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NHFKFMEO_02121 2.4e-50 yfkI S gas vesicle protein
NHFKFMEO_02122 9.7e-144 yihY S Belongs to the UPF0761 family
NHFKFMEO_02123 5e-08
NHFKFMEO_02124 7.7e-219 ycaD EGP COG0477 Permeases of the major facilitator superfamily
NHFKFMEO_02125 6.1e-183 cax P COG0387 Ca2 H antiporter
NHFKFMEO_02126 1.2e-146 yfkD S YfkD-like protein
NHFKFMEO_02127 6e-149 yfkC M Mechanosensitive ion channel
NHFKFMEO_02128 5.4e-222 yfkA S YfkB-like domain
NHFKFMEO_02129 1.1e-26 yfjT
NHFKFMEO_02130 2.6e-154 pdaA G deacetylase
NHFKFMEO_02131 6.8e-148 yfjR 1.1.1.31 I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
NHFKFMEO_02132 6.5e-184 corA P Mediates influx of magnesium ions
NHFKFMEO_02133 1.3e-167 yfjP 3.2.2.21 L COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
NHFKFMEO_02134 4e-267 rumA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NHFKFMEO_02135 5.1e-44 S YfzA-like protein
NHFKFMEO_02136 8.1e-190 yfjN J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NHFKFMEO_02137 9.6e-85 yfjM S Psort location Cytoplasmic, score
NHFKFMEO_02138 4.4e-191 acoA C COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
NHFKFMEO_02139 2.9e-190 acoB C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
NHFKFMEO_02140 2.9e-197 acoC 2.3.1.12, 2.3.1.61 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
NHFKFMEO_02141 8.6e-254 acoL 1.8.1.4 C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
NHFKFMEO_02142 0.0 acoR KQ COG3284 Transcriptional activator of acetoin glycerol metabolism
NHFKFMEO_02143 1.2e-25 sspH S Belongs to the SspH family
NHFKFMEO_02144 4e-56 yfjF S UPF0060 membrane protein
NHFKFMEO_02145 1.8e-85 S Family of unknown function (DUF5381)
NHFKFMEO_02146 2.4e-123 yfjC
NHFKFMEO_02147 7.3e-172 yfjB
NHFKFMEO_02148 2.6e-44 yfjA S Belongs to the WXG100 family
NHFKFMEO_02149 4.9e-262 aglB 3.2.1.122, 3.2.1.22, 3.2.1.86 GH4,GT4 G COG1486 Alpha-galactosidases 6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases
NHFKFMEO_02150 7.1e-141 glvR K Helix-turn-helix domain, rpiR family
NHFKFMEO_02151 1e-295 glvC 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
NHFKFMEO_02152 2e-308 yfiB3 V ABC transporter
NHFKFMEO_02153 0.0 yfiC V COG1132 ABC-type multidrug transport system, ATPase and permease components
NHFKFMEO_02154 9.8e-65 mhqP S DoxX
NHFKFMEO_02155 5.7e-163 yfiE 1.13.11.2 S glyoxalase
NHFKFMEO_02156 1.1e-220 yxjM T Histidine kinase
NHFKFMEO_02157 4.6e-112 KT LuxR family transcriptional regulator
NHFKFMEO_02158 6.4e-168 V ABC transporter, ATP-binding protein
NHFKFMEO_02159 2.9e-205 V ABC-2 family transporter protein
NHFKFMEO_02160 9.9e-203 V COG0842 ABC-type multidrug transport system, permease component
NHFKFMEO_02161 8.3e-99 padR K transcriptional
NHFKFMEO_02162 4.4e-80 estA 3.1.1.3 S acetyltransferases and hydrolases with the alpha beta hydrolase fold
NHFKFMEO_02163 2e-197 yfiQ G COG3936 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
NHFKFMEO_02164 1.2e-97 yfiT S Belongs to the metal hydrolase YfiT family
NHFKFMEO_02165 4.3e-286 yfiU EGP Major facilitator Superfamily
NHFKFMEO_02166 4.9e-79 yfiV K transcriptional
NHFKFMEO_02167 0.0 mprF 2.3.2.3 S Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NHFKFMEO_02168 3.5e-177 yfiY P ABC transporter substrate-binding protein
NHFKFMEO_02169 1.5e-175 yfiZ P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NHFKFMEO_02170 6.8e-171 yfhA P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NHFKFMEO_02171 1.4e-164 yfhB 5.3.3.17 S PhzF family
NHFKFMEO_02172 1.5e-106 yfhC C nitroreductase
NHFKFMEO_02173 2.1e-25 yfhD S YfhD-like protein
NHFKFMEO_02175 2.4e-172 yfhF S nucleoside-diphosphate sugar epimerase
NHFKFMEO_02176 5.7e-141 recX 2.4.1.337 GT4 S Modulates RecA activity
NHFKFMEO_02177 9.7e-52 yfhH S Protein of unknown function (DUF1811)
NHFKFMEO_02179 1.1e-209 yfhI EGP Major facilitator Superfamily
NHFKFMEO_02180 6.2e-20 sspK S reproduction
NHFKFMEO_02181 2.9e-44 yfhJ S WVELL protein
NHFKFMEO_02182 2.4e-87 batE T Bacterial SH3 domain homologues
NHFKFMEO_02183 3.5e-51 yfhL S SdpI/YhfL protein family
NHFKFMEO_02184 6.7e-172 yfhM S Alpha beta hydrolase
NHFKFMEO_02185 2.7e-185 csbB GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
NHFKFMEO_02186 0.0 yfhO S Bacterial membrane protein YfhO
NHFKFMEO_02187 5.5e-186 yfhP S membrane-bound metal-dependent
NHFKFMEO_02188 8.6e-212 mutY L A G-specific
NHFKFMEO_02189 6.9e-36 yfhS
NHFKFMEO_02190 2.9e-134 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
NHFKFMEO_02191 2.4e-08 sspE S Small, acid-soluble spore protein, gamma-type
NHFKFMEO_02192 1.5e-37 ygaB S YgaB-like protein
NHFKFMEO_02193 1.3e-104 ygaC J Belongs to the UPF0374 family
NHFKFMEO_02194 1.8e-301 ygaD V ABC transporter
NHFKFMEO_02195 8.7e-180 ygaE S Membrane
NHFKFMEO_02196 1.2e-244 gsaB 5.4.3.8 H Glutamate-1-semialdehyde aminotransferase
NHFKFMEO_02197 6.3e-87 bcp 1.11.1.15 O Peroxiredoxin
NHFKFMEO_02198 4e-80 perR P Belongs to the Fur family
NHFKFMEO_02199 1.1e-54 ygzB S UPF0295 protein
NHFKFMEO_02200 3.3e-166 ygxA S Nucleotidyltransferase-like
NHFKFMEO_02201 9.8e-230 mtnK 2.7.1.100 F Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
NHFKFMEO_02202 1.4e-195 mtnA 5.3.1.23 E Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
NHFKFMEO_02204 7e-89 ogt 2.1.1.63 L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NHFKFMEO_02205 0.0 kinE 2.7.13.3 T Histidine kinase
NHFKFMEO_02206 6.5e-190 ykrP G COG3594 Fucose 4-O-acetylase and related acetyltransferases
NHFKFMEO_02207 2.2e-19 ykzE
NHFKFMEO_02208 1.2e-10 ydfR S Protein of unknown function (DUF421)
NHFKFMEO_02209 1.7e-233 ktrB P COG0168 Trk-type K transport systems, membrane components
NHFKFMEO_02210 3.5e-155 htpX O Belongs to the peptidase M48B family
NHFKFMEO_02211 5.6e-124 ykrK S Domain of unknown function (DUF1836)
NHFKFMEO_02212 1.9e-26 sspD S small acid-soluble spore protein
NHFKFMEO_02213 4.4e-110 rsgI S Anti-sigma factor N-terminus
NHFKFMEO_02214 9.5e-130 sigI K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NHFKFMEO_02215 2.1e-177 ykoY P COG0861 Membrane protein TerC, possibly involved in tellurium resistance
NHFKFMEO_02216 3.5e-109 ykoX S membrane-associated protein
NHFKFMEO_02217 0.0 ydcR 2.7.7.65 T Diguanylate cyclase
NHFKFMEO_02218 3.6e-160 ku L With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NHFKFMEO_02219 0.0 ligD 6.5.1.1 L ATP-dependent DNA ligase
NHFKFMEO_02220 2.1e-185 ykoT GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
NHFKFMEO_02221 0.0 ykoS
NHFKFMEO_02222 3.5e-154 ykoQ S Calcineurin-like phosphoesterase superfamily domain
NHFKFMEO_02223 1.4e-98 ykoP G polysaccharide deacetylase
NHFKFMEO_02224 3.6e-218 ugtP 2.4.1.315 GT28 M COG0707 UDP-N-acetylglucosamine LPS N-acetylglucosamine transferase
NHFKFMEO_02225 1.3e-81 mhqR K transcriptional
NHFKFMEO_02226 6.9e-26 ykoL
NHFKFMEO_02227 5.9e-18
NHFKFMEO_02228 1.4e-53 tnrA K transcriptional
NHFKFMEO_02229 2.2e-222 mgtE P Acts as a magnesium transporter
NHFKFMEO_02232 8.3e-85 ykoJ S Peptidase propeptide and YPEB domain
NHFKFMEO_02233 9.9e-110 ykoI S Peptidase propeptide and YPEB domain
NHFKFMEO_02234 1.4e-240 ykoH 2.7.13.3 T Histidine kinase
NHFKFMEO_02235 7.9e-123 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
NHFKFMEO_02236 7.4e-109 ykoF S YKOF-related Family
NHFKFMEO_02237 6.9e-99 ykoE S ABC-type cobalt transport system, permease component
NHFKFMEO_02238 2.5e-308 P ABC transporter, ATP-binding protein
NHFKFMEO_02239 5.3e-136 ykoC P Cobalt transport protein
NHFKFMEO_02240 6.3e-151 T COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
NHFKFMEO_02241 2.5e-175 isp O Belongs to the peptidase S8 family
NHFKFMEO_02242 0.0 metE 2.1.1.14 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NHFKFMEO_02243 2.8e-87 guaD 3.5.4.12, 3.5.4.3, 3.5.4.33 FJ COG0590 Cytosine adenosine deaminases
NHFKFMEO_02244 2.4e-71 ohrB O Organic hydroperoxide resistance protein
NHFKFMEO_02245 4.8e-73 ohrR K COG1846 Transcriptional regulators
NHFKFMEO_02246 1.3e-70 ohrA O Organic hydroperoxide resistance protein
NHFKFMEO_02247 8.1e-227 proA 1.2.1.41, 1.2.1.81 E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NHFKFMEO_02248 5.2e-201 proB 2.7.2.11 E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NHFKFMEO_02249 3.9e-170 purU 2.7.7.72, 3.5.1.10 F Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)
NHFKFMEO_02250 7e-50 ykkD P Multidrug resistance protein
NHFKFMEO_02251 3.5e-55 ykkC P Multidrug resistance protein
NHFKFMEO_02252 1e-98 ykkB 2.3.1.128 J COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
NHFKFMEO_02253 2.2e-96 ykkA S Protein of unknown function (DUF664)
NHFKFMEO_02254 2.3e-128 ykjA S Protein of unknown function (DUF421)
NHFKFMEO_02255 5.5e-09
NHFKFMEO_02256 1.7e-226 hmp 1.14.12.17 C Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NHFKFMEO_02257 3.4e-92 ykhA 3.1.2.20 I Acyl-CoA hydrolase
NHFKFMEO_02258 2e-160 ykgA E Amidinotransferase
NHFKFMEO_02259 3.6e-204 pgl 3.1.1.31 G 6-phosphogluconolactonase
NHFKFMEO_02260 5.5e-186 ykfD E Belongs to the ABC transporter superfamily
NHFKFMEO_02261 9.7e-166 ykfC 3.4.14.13 M COG0791 Cell wall-associated hydrolases (invasion-associated proteins)
NHFKFMEO_02262 2.3e-201 ykfB 5.1.1.20 M Belongs to the mandelate racemase muconate lactonizing enzyme family
NHFKFMEO_02263 1.3e-176 ykfA 3.4.17.13 V proteins, homologs of microcin C7 resistance protein MccF
NHFKFMEO_02265 0.0 dppE E ABC transporter substrate-binding protein
NHFKFMEO_02266 1.3e-187 dppD P Belongs to the ABC transporter superfamily
NHFKFMEO_02267 3.3e-175 dppC EP COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
NHFKFMEO_02268 1.1e-159 dppB P COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
NHFKFMEO_02269 2.5e-152 dppA E D-aminopeptidase
NHFKFMEO_02270 6.9e-134 proG 1.5.1.2 E Pyrroline-5-carboxylate reductase
NHFKFMEO_02271 7.5e-210 htrA 3.4.21.107 O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NHFKFMEO_02273 8.4e-179 ykcC GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
NHFKFMEO_02274 0.0 ykcB M COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NHFKFMEO_02275 1e-181 mhqA E COG0346 Lactoylglutathione lyase and related lyases
NHFKFMEO_02276 4e-240 steT E amino acid
NHFKFMEO_02277 6.9e-110 ykaA P COG1392 Phosphate transport regulator (distant homolog of PhoU)
NHFKFMEO_02278 5.8e-175 pit P phosphate transporter
NHFKFMEO_02279 1.8e-136 spoIISA S Toxin SpoIISA, type II toxin-antitoxin system
NHFKFMEO_02280 6.7e-23 spoIISB S Stage II sporulation protein SB
NHFKFMEO_02281 1.2e-163 xlyA 3.5.1.28 M n-acetylmuramoyl-L-alanine amidase
NHFKFMEO_02282 9.3e-40 xhlB S SPP1 phage holin
NHFKFMEO_02283 6.2e-39 xhlA S Haemolysin XhlA
NHFKFMEO_02284 1.7e-151 xepA
NHFKFMEO_02285 5.5e-22 xkdX
NHFKFMEO_02286 5.4e-53 xkdW S XkdW protein
NHFKFMEO_02287 1e-261
NHFKFMEO_02288 1.5e-40
NHFKFMEO_02289 1.2e-103 xkdU S Uncharacterised protein conserved in bacteria (DUF2313)
NHFKFMEO_02290 6.7e-190 xkdT S Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
NHFKFMEO_02291 3.1e-69 xkdS S Protein of unknown function (DUF2634)
NHFKFMEO_02292 2.1e-39 xkdR S Protein of unknown function (DUF2577)
NHFKFMEO_02293 4.8e-182 yqbQ 3.2.1.96 G NLP P60 protein
NHFKFMEO_02294 4.1e-121 xkdP S Lysin motif
NHFKFMEO_02295 0.0 xkdO L Transglycosylase SLT domain
NHFKFMEO_02296 1.9e-77 S Phage XkdN-like tail assembly chaperone protein, TAC
NHFKFMEO_02297 6.1e-76 xkdM S Phage tail tube protein
NHFKFMEO_02298 3.2e-256 xkdK S Phage tail sheath C-terminal domain
NHFKFMEO_02299 1.9e-77 xkdJ
NHFKFMEO_02300 4.4e-88 xkdI S Bacteriophage HK97-gp10, putative tail-component
NHFKFMEO_02301 8.7e-65 yqbH S Domain of unknown function (DUF3599)
NHFKFMEO_02302 2.8e-61 yqbG S Protein of unknown function (DUF3199)
NHFKFMEO_02303 5.8e-169 xkdG S Phage capsid family
NHFKFMEO_02304 1.2e-133 yqbD 2.1.1.72 L Putative phage serine protease XkdF
NHFKFMEO_02305 4.6e-285 yqbA S portal protein
NHFKFMEO_02306 6.9e-253 xtmB S phage terminase, large subunit
NHFKFMEO_02307 1.4e-139 xtmA L phage terminase small subunit
NHFKFMEO_02308 7e-84 xpf K COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog
NHFKFMEO_02309 4.6e-10 yqaO S Phage-like element PBSX protein XtrA
NHFKFMEO_02312 4.1e-118 xkdC L Bacterial dnaA protein
NHFKFMEO_02313 5.9e-157 xkdB K sequence-specific DNA binding
NHFKFMEO_02315 3.2e-56 xre K Helix-turn-helix XRE-family like proteins
NHFKFMEO_02316 1e-110 xkdA E IrrE N-terminal-like domain
NHFKFMEO_02317 9.8e-160 ydbD P Catalase
NHFKFMEO_02318 2.8e-108 yjqB S Pfam:DUF867
NHFKFMEO_02319 1.8e-60 yjqA S Bacterial PH domain
NHFKFMEO_02320 6.8e-165 xlyA 3.5.1.28 CBM50 M N-acetylmuramoyl-L-alanine amidase
NHFKFMEO_02321 5.2e-37 S YCII-related domain
NHFKFMEO_02323 1e-212 S response regulator aspartate phosphatase
NHFKFMEO_02324 1.4e-245 ftsH2 3.4.21.53 O AAA domain (dynein-related subfamily)
NHFKFMEO_02325 2.3e-78 yjoA S DinB family
NHFKFMEO_02326 9.7e-130 MA20_18170 S membrane transporter protein
NHFKFMEO_02327 5.6e-283 uxaA 4.2.1.7, 4.4.1.24 G Altronate
NHFKFMEO_02328 2.3e-281 uxaB 1.1.1.17, 1.1.1.58 G tagaturonate reductase activity
NHFKFMEO_02329 6.8e-184 exuR K transcriptional
NHFKFMEO_02330 1.1e-226 exuT G Sugar (and other) transporter
NHFKFMEO_02331 2.3e-153 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
NHFKFMEO_02332 8.9e-214 uxuA 4.2.1.8 G Catalyzes the dehydration of D-mannonate
NHFKFMEO_02333 3.1e-192 rspB 1.1.1.380 E Alcohol dehydrogenase GroES-like domain
NHFKFMEO_02334 1.8e-187 yjmC 1.1.1.350 C Belongs to the LDH2 MDH2 oxidoreductase family
NHFKFMEO_02335 9.2e-248 yjmB G symporter YjmB
NHFKFMEO_02336 7.9e-279 uxaC 5.3.1.12 G glucuronate isomerase
NHFKFMEO_02337 2.6e-219 yjlD 1.6.99.3 C NADH dehydrogenase
NHFKFMEO_02338 7.1e-66 yjlC S Protein of unknown function (DUF1641)
NHFKFMEO_02339 1.3e-90 yjlB S Cupin domain
NHFKFMEO_02340 6.7e-176 yjlA EG Putative multidrug resistance efflux transporter
NHFKFMEO_02341 2e-135 pstB 3.6.3.27 P ATPases associated with a variety of cellular activities
NHFKFMEO_02342 5.6e-122 ybbM S transport system, permease component
NHFKFMEO_02343 1.5e-144 hemD 2.1.1.107, 4.2.1.75 H Uroporphyrinogen-III synthase
NHFKFMEO_02344 3.1e-29
NHFKFMEO_02345 4.5e-219 oleD GT1 CG COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase
NHFKFMEO_02346 1.2e-222 yjiB 1.14.13.154, 1.14.15.8 C Cytochrome P450
NHFKFMEO_02348 1e-113 yjhB 3.6.1.13, 3.6.1.55 F ADP-ribose pyrophosphatase
NHFKFMEO_02349 8.7e-07 S Domain of unknown function (DUF4352)
NHFKFMEO_02350 4.3e-95 yjgD S Protein of unknown function (DUF1641)
NHFKFMEO_02351 0.0 yjgC 1.17.1.10, 1.17.1.9 C formate dehydrogenase (NAD+) activity
NHFKFMEO_02352 7.6e-103 yjgB S Domain of unknown function (DUF4309)
NHFKFMEO_02353 6e-45 T PhoQ Sensor
NHFKFMEO_02354 1.2e-168 yjfC O Predicted Zn-dependent protease (DUF2268)
NHFKFMEO_02355 8.9e-20 yjfB S Putative motility protein
NHFKFMEO_02356 1.4e-81 S Protein of unknown function (DUF2690)
NHFKFMEO_02357 4.9e-265 xynD 3.5.1.104 G Polysaccharide deacetylase
NHFKFMEO_02359 8.1e-71 cyoE 2.5.1.141 O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
NHFKFMEO_02360 7.9e-76 cyoE 2.5.1.141 O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
NHFKFMEO_02361 1.3e-51 yjdJ S Domain of unknown function (DUF4306)
NHFKFMEO_02362 4.2e-29 S Domain of unknown function (DUF4177)
NHFKFMEO_02363 6.8e-81 ybaK S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NHFKFMEO_02365 4.5e-91 yjdG 2.3.1.128 J Acetyltransferase (GNAT) domain
NHFKFMEO_02366 4.5e-49 yjdF S Protein of unknown function (DUF2992)
NHFKFMEO_02367 8.7e-189 manA 5.3.1.8 G mannose-6-phosphate isomerase
NHFKFMEO_02368 0.0 manP 2.7.1.191, 2.7.1.202 G phosphotransferase system
NHFKFMEO_02369 0.0 manR 2.7.1.200, 2.7.1.202 GKT transcriptional antiterminator
NHFKFMEO_02371 1e-139 IQ Enoyl-(Acyl carrier protein) reductase
NHFKFMEO_02372 5.4e-46 yjcS S Antibiotic biosynthesis monooxygenase
NHFKFMEO_02379 1.3e-10 K Cro/C1-type HTH DNA-binding domain
NHFKFMEO_02380 1.5e-46
NHFKFMEO_02381 2.8e-79 S SMI1-KNR4 cell-wall
NHFKFMEO_02382 4.2e-285 L A nuclease of the HNH/ENDO VII superfamily with conserved LHH
NHFKFMEO_02383 1.2e-107 S aspartate phosphatase
NHFKFMEO_02388 6.5e-71 S peptidoglycan catabolic process
NHFKFMEO_02389 2.7e-11
NHFKFMEO_02390 4.4e-64
NHFKFMEO_02392 1.1e-30
NHFKFMEO_02393 3e-18
NHFKFMEO_02395 9.6e-32 S KTSC domain
NHFKFMEO_02396 4.3e-311 D Phage tail tape measure protein
NHFKFMEO_02403 4.4e-12
NHFKFMEO_02404 5.1e-34 K Helix-turn-helix XRE-family like proteins
NHFKFMEO_02405 6.4e-156
NHFKFMEO_02406 1.1e-89
NHFKFMEO_02409 1.6e-31
NHFKFMEO_02411 1e-13 K Cro Cl family transcriptional regulator
NHFKFMEO_02413 3.9e-09
NHFKFMEO_02415 8.5e-34 K Cro/C1-type HTH DNA-binding domain
NHFKFMEO_02416 7.1e-33 K Cro/C1-type HTH DNA-binding domain
NHFKFMEO_02417 4.4e-103 L Phage integrase family
NHFKFMEO_02418 1.7e-123 S Helix-turn-helix domain
NHFKFMEO_02419 6.7e-198 L Belongs to the 'phage' integrase family
NHFKFMEO_02421 9.5e-209 yjcL S Protein of unknown function (DUF819)
NHFKFMEO_02422 1.7e-96 rimJ 2.3.1.128 J Alanine acetyltransferase
NHFKFMEO_02423 1.9e-217 metC 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
NHFKFMEO_02424 6.8e-212 metB 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
NHFKFMEO_02425 1.8e-138 yjcH P COG2382 Enterochelin esterase and related enzymes
NHFKFMEO_02426 2.9e-93 yjcG J Belongs to the 2H phosphoesterase superfamily. YjcG family
NHFKFMEO_02427 3e-72 yjcF S COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
NHFKFMEO_02428 1.7e-38
NHFKFMEO_02429 0.0 yjcD 3.6.4.12 L DNA helicase
NHFKFMEO_02430 2.9e-38 spoVIF S Stage VI sporulation protein F
NHFKFMEO_02433 9.6e-56 yjcA S Protein of unknown function (DUF1360)
NHFKFMEO_02434 5.3e-52 cotV S Spore Coat Protein X and V domain
NHFKFMEO_02435 5.5e-26 cotW
NHFKFMEO_02436 3.6e-72 cotX S Spore Coat Protein X and V domain
NHFKFMEO_02437 7.6e-96 cotY S Spore coat protein Z
NHFKFMEO_02438 4.4e-82 cotZ S Spore coat protein
NHFKFMEO_02439 5.9e-54 yjbX S Spore coat protein
NHFKFMEO_02440 3.2e-141 fabI 1.3.1.10, 1.3.1.9 I Enoyl- acyl-carrier-protein reductase NADH
NHFKFMEO_02441 2e-149 thiD 2.5.1.3, 2.7.1.35, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Phosphomethylpyrimidine kinase
NHFKFMEO_02442 6e-188 thiF 2.7.7.73, 2.7.7.80 H COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
NHFKFMEO_02443 1.5e-135 thiG 2.8.1.10 H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S
NHFKFMEO_02444 2.6e-29 thiS H thiamine diphosphate biosynthetic process
NHFKFMEO_02445 8.3e-215 thiO 1.4.3.19 E Glycine oxidase
NHFKFMEO_02446 3.2e-107 tenI 2.5.1.3, 5.3.99.10 H Transcriptional regulator TenI
NHFKFMEO_02447 5.8e-137 tenA 3.5.99.2 K Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NHFKFMEO_02448 0.0 yjbQ P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
NHFKFMEO_02449 8.7e-128 prpE 3.1.3.16, 3.6.1.41 T Asymmetrically hydrolyzes Ap4p to yield AMP and ATP
NHFKFMEO_02450 6.8e-159 yjbO 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
NHFKFMEO_02451 2.1e-151 nadK 2.7.1.23 G Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NHFKFMEO_02452 2.6e-112 yjbM 2.7.6.5 S GTP pyrophosphokinase
NHFKFMEO_02453 2.7e-61 yjbL S Belongs to the UPF0738 family
NHFKFMEO_02454 1.2e-100 yjbK S protein conserved in bacteria
NHFKFMEO_02455 3.1e-85 yjbJ M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)
NHFKFMEO_02456 3.7e-72 yjbI S Bacterial-like globin
NHFKFMEO_02457 1.2e-168 yjbH Q dithiol-disulfide isomerase involved in polyketide biosynthesis
NHFKFMEO_02459 1.8e-20
NHFKFMEO_02460 0.0 pepF E oligoendopeptidase F
NHFKFMEO_02461 8e-221 yjbF S Competence protein
NHFKFMEO_02462 4.4e-115 mecA NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC
NHFKFMEO_02463 6e-112 yjbE P Integral membrane protein TerC family
NHFKFMEO_02464 3.5e-67 spxA 1.20.4.1 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
NHFKFMEO_02465 2.6e-103 yjbC K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
NHFKFMEO_02466 9.1e-204 yjbB EGP Major Facilitator Superfamily
NHFKFMEO_02467 2.7e-171 oppF E Belongs to the ABC transporter superfamily
NHFKFMEO_02468 6.8e-198 oppD P Belongs to the ABC transporter superfamily
NHFKFMEO_02469 7.7e-166 oppC EP COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
NHFKFMEO_02470 2.7e-166 oppB P COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
NHFKFMEO_02471 0.0 oppA E ABC transporter substrate-binding protein
NHFKFMEO_02472 6.1e-185 trpS 6.1.1.2 J Tryptophanyl-tRNA synthetase
NHFKFMEO_02473 6.5e-147 yjbA S Belongs to the UPF0736 family
NHFKFMEO_02474 7.9e-163 appC EP COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
NHFKFMEO_02475 1.3e-171 oppB P COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
NHFKFMEO_02476 1.6e-251 appA E COG0747 ABC-type dipeptide transport system, periplasmic component
NHFKFMEO_02477 6.5e-187 appF E Belongs to the ABC transporter superfamily
NHFKFMEO_02478 1.8e-184 appD P Belongs to the ABC transporter superfamily
NHFKFMEO_02479 7.8e-151 yjaZ O Zn-dependent protease
NHFKFMEO_02480 1.8e-234 fabF 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
NHFKFMEO_02481 3.9e-173 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NHFKFMEO_02482 2.7e-22 yjzB
NHFKFMEO_02483 4.7e-25 comZ S ComZ
NHFKFMEO_02484 1.1e-183 med S Transcriptional activator protein med
NHFKFMEO_02485 1.8e-101 yjaV
NHFKFMEO_02486 6.8e-141 yjaU I carboxylic ester hydrolase activity
NHFKFMEO_02487 2.3e-16 yjzD S Protein of unknown function (DUF2929)
NHFKFMEO_02488 9.5e-28 yjzC S YjzC-like protein
NHFKFMEO_02489 1.5e-175 argF 2.1.3.3 E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NHFKFMEO_02490 0.0 carB 6.3.5.5 EF Carbamoyl-phosphate synthetase ammonia chain
NHFKFMEO_02491 4.4e-205 carA 6.3.5.5 F Carbamoyl-phosphate synthetase glutamine chain
NHFKFMEO_02492 1.4e-217 argD 2.6.1.11, 2.6.1.17 E acetylornithine aminotransferase
NHFKFMEO_02493 4.1e-136 argB 2.7.2.8 E Belongs to the acetylglutamate kinase family. ArgB subfamily
NHFKFMEO_02494 2.9e-229 argJ 2.3.1.1, 2.3.1.35, 2.7.2.8 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NHFKFMEO_02495 9.5e-197 argC 1.2.1.38 E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NHFKFMEO_02496 4.9e-88 norB G Major Facilitator Superfamily
NHFKFMEO_02497 1.2e-266 yitY C D-arabinono-1,4-lactone oxidase
NHFKFMEO_02498 1.5e-22 pilT S Proteolipid membrane potential modulator
NHFKFMEO_02499 4.7e-51 yitW S metal-sulfur cluster biosynthetic enzyme
NHFKFMEO_02500 1e-142 yjfP S COG1073 Hydrolases of the alpha beta superfamily
NHFKFMEO_02501 2.1e-154 yitU 3.1.3.104 S hydrolases of the HAD superfamily
NHFKFMEO_02503 2.8e-17 S Protein of unknown function (DUF3813)
NHFKFMEO_02504 1.4e-72 ipi S Intracellular proteinase inhibitor
NHFKFMEO_02505 6.6e-148 yitT S Uncharacterized protein conserved in bacteria (DUF2179)
NHFKFMEO_02506 2.5e-158 yitS S protein conserved in bacteria
NHFKFMEO_02507 6.7e-311 nprB 3.4.24.28 E Peptidase M4
NHFKFMEO_02508 1.4e-44 yitR S Domain of unknown function (DUF3784)
NHFKFMEO_02509 6.6e-94
NHFKFMEO_02510 1.5e-58 K Transcriptional regulator PadR-like family
NHFKFMEO_02511 7.6e-97 S Sporulation delaying protein SdpA
NHFKFMEO_02512 1.4e-170
NHFKFMEO_02513 8.5e-94
NHFKFMEO_02514 5.8e-160 cvfB S protein conserved in bacteria
NHFKFMEO_02515 8.6e-55 yajQ S Belongs to the UPF0234 family
NHFKFMEO_02516 0.0 yitJ 1.5.1.20, 2.1.1.10, 2.1.1.13 E Catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine
NHFKFMEO_02517 1.2e-71 yjcF S Acetyltransferase (GNAT) domain
NHFKFMEO_02518 8.1e-154 yitH K Acetyltransferase (GNAT) domain
NHFKFMEO_02519 1.5e-228 yitG EGP Major facilitator Superfamily
NHFKFMEO_02520 1.6e-221 yitF 5.5.1.27 M Belongs to the mandelate racemase muconate lactonizing enzyme family
NHFKFMEO_02521 1.7e-108 yitE S Uncharacterised 5xTM membrane BCR, YitT family COG1284
NHFKFMEO_02522 1.6e-140 yitD 4.4.1.19 S synthase
NHFKFMEO_02523 9e-119 comB 3.1.3.71 H Belongs to the ComB family
NHFKFMEO_02524 2.1e-142 cysH 1.8.4.10, 1.8.4.8, 2.7.1.25 EH Belongs to the PAPS reductase family. CysH subfamily
NHFKFMEO_02525 3.7e-229 sat 2.7.7.4 P Belongs to the sulfate adenylyltransferase family
NHFKFMEO_02526 1.9e-112 cysC 1.8.4.10, 1.8.4.8, 2.7.1.25, 2.7.7.4 P Catalyzes the synthesis of activated sulfate
NHFKFMEO_02527 3.1e-155 yisY I hydrolases or acyltransferases (alpha beta hydrolase superfamily)
NHFKFMEO_02528 4e-36 mcbG S Pentapeptide repeats (9 copies)
NHFKFMEO_02529 4.8e-279 yisV K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
NHFKFMEO_02530 1.9e-104 argO S Lysine exporter protein LysE YggA
NHFKFMEO_02531 3.1e-92 yisT S DinB family
NHFKFMEO_02532 1.5e-194 yisS 1.1.1.370 S Oxidoreductase family, C-terminal alpha/beta domain
NHFKFMEO_02533 1.5e-183 purR K helix_turn _helix lactose operon repressor
NHFKFMEO_02534 1.2e-160 yisR K Transcriptional regulator
NHFKFMEO_02535 1.5e-242 yisQ V Mate efflux family protein
NHFKFMEO_02536 2.8e-148 crtB 2.5.1.21, 2.5.1.32, 2.5.1.99 I phytoene
NHFKFMEO_02537 3.9e-87 yizA S Damage-inducible protein DinB
NHFKFMEO_02538 0.0 asnO 6.3.5.4 E Asparagine synthase
NHFKFMEO_02539 2.1e-102 yisN S Protein of unknown function (DUF2777)
NHFKFMEO_02540 0.0 wprA O Belongs to the peptidase S8 family
NHFKFMEO_02541 3.9e-57 yisL S UPF0344 protein
NHFKFMEO_02542 7.1e-172 yisK Q COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)
NHFKFMEO_02543 1.1e-172 cotH M Spore Coat
NHFKFMEO_02544 1.5e-22 yisI S Spo0E like sporulation regulatory protein
NHFKFMEO_02545 1.9e-33 gerPA S Spore germination protein
NHFKFMEO_02546 4e-34 gerPB S cell differentiation
NHFKFMEO_02547 1.8e-54 gerPC S Spore germination protein
NHFKFMEO_02548 6.3e-24 gerPD S Spore germination protein
NHFKFMEO_02549 3e-66 gerPE S Spore germination protein GerPE
NHFKFMEO_02550 4.5e-32 gerPF S Spore germination protein gerPA/gerPF
NHFKFMEO_02551 1.1e-49 yisB V COG1403 Restriction endonuclease
NHFKFMEO_02552 0.0 sbcC L COG0419 ATPase involved in DNA repair
NHFKFMEO_02553 6.9e-220 sbcD L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
NHFKFMEO_02554 0.0 addA 3.6.4.12 L ATP-dependent helicase nuclease subunit A
NHFKFMEO_02555 0.0 addB 3.1.21.3, 3.6.4.12 L ATP-dependent helicase deoxyribonuclease subunit B
NHFKFMEO_02556 1.1e-77 yhjR S Rubrerythrin
NHFKFMEO_02557 0.0 S Sugar transport-related sRNA regulator N-term
NHFKFMEO_02558 7.9e-211 EGP Transmembrane secretion effector
NHFKFMEO_02559 5.1e-199 abrB S membrane
NHFKFMEO_02560 1.6e-188 yhjM 5.1.1.1 K Transcriptional regulator
NHFKFMEO_02561 7.7e-252 ntdA 2.6.1.104 E Belongs to the DegT DnrJ EryC1 family
NHFKFMEO_02562 4.5e-160 ntdB 3.1.3.92 S Sucrose-6F-phosphate phosphohydrolase
NHFKFMEO_02563 3.2e-200 thuB 1.1.1.361 S Oxidoreductase family, C-terminal alpha/beta domain
NHFKFMEO_02564 4.5e-214 glcP G Major Facilitator Superfamily
NHFKFMEO_02565 3.5e-94 yhjH K helix_turn_helix multiple antibiotic resistance protein
NHFKFMEO_02566 2.4e-278 yhjG CH FAD binding domain
NHFKFMEO_02567 1.2e-91 sipV 3.4.21.89 U Belongs to the peptidase S26 family
NHFKFMEO_02568 9.1e-110 yhjE S SNARE associated Golgi protein
NHFKFMEO_02569 6.7e-60 yhjD
NHFKFMEO_02570 6.9e-27 yhjC S Protein of unknown function (DUF3311)
NHFKFMEO_02571 1.3e-263 yhjB E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NHFKFMEO_02572 7.8e-42 yhjA S Excalibur calcium-binding domain
NHFKFMEO_02573 2.1e-168 IQ Enoyl-(Acyl carrier protein) reductase
NHFKFMEO_02574 4.2e-109 comK K Competence transcription factor
NHFKFMEO_02575 1.3e-32 yhzC S IDEAL
NHFKFMEO_02576 1.6e-157 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
NHFKFMEO_02577 4.7e-301 yhfW CE COG0665 Glycine D-amino acid oxidases (deaminating)
NHFKFMEO_02578 1.7e-182 hemAT NT chemotaxis protein
NHFKFMEO_02579 6.5e-91 bioY S BioY family
NHFKFMEO_02580 2.2e-268 yhfT 6.2.1.3 IQ AMP-binding enzyme C-terminal domain
NHFKFMEO_02581 1.2e-194 vraB 2.3.1.9 I Belongs to the thiolase family
NHFKFMEO_02582 1.9e-109 yhfR 3.1.3.73 G Belongs to the phosphoglycerate mutase family
NHFKFMEO_02583 4.3e-159 yfmC M Periplasmic binding protein
NHFKFMEO_02584 5.4e-181 yhfP 1.1.1.1 C Quinone oxidoreductase
NHFKFMEO_02585 3.1e-75 VY92_01935 K acetyltransferase
NHFKFMEO_02586 5.6e-198 aprE 3.4.21.62 O Belongs to the peptidase S8 family
NHFKFMEO_02587 3.5e-241 yhfN 3.4.24.84 O Peptidase M48
NHFKFMEO_02588 1.9e-65 yhfM
NHFKFMEO_02589 7e-300 fadD 6.2.1.3 IQ AMP-binding enzyme C-terminal domain
NHFKFMEO_02590 1.9e-110 yhfK GM NmrA-like family
NHFKFMEO_02591 1.7e-190 lplJ 6.3.1.20 H Lipoate-protein ligase
NHFKFMEO_02592 2e-140 yhfI S COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III
NHFKFMEO_02593 3.8e-227 gltP C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
NHFKFMEO_02594 3.7e-72 3.4.13.21 S ASCH
NHFKFMEO_02595 1e-198 yhfE 3.2.1.4 GH5,GH9 G peptidase M42
NHFKFMEO_02596 4.1e-136 yhfC S Putative membrane peptidase family (DUF2324)
NHFKFMEO_02597 4.3e-183 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NHFKFMEO_02598 2.5e-237 yhgE S YhgE Pip N-terminal domain protein
NHFKFMEO_02599 5.4e-101 yhgD K Transcriptional regulator
NHFKFMEO_02600 1.7e-268 hemG 1.14.19.9, 1.3.3.15, 1.3.3.4 H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NHFKFMEO_02601 3.6e-179 hemH 4.99.1.1, 4.99.1.9 H Catalyzes the ferrous insertion into protoporphyrin IX
NHFKFMEO_02602 1.6e-202 hemE 4.1.1.37 H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NHFKFMEO_02603 0.0 pbpF 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
NHFKFMEO_02604 2.9e-90 traP 1.14.99.57, 6.2.1.3 S enzyme involved in biosynthesis of extracellular polysaccharides
NHFKFMEO_02605 7.9e-27 1.15.1.2 C Rubrerythrin
NHFKFMEO_02606 2.7e-231 yhfA C membrane
NHFKFMEO_02607 5.7e-230 yhaA 3.5.1.47 E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
NHFKFMEO_02608 1.4e-114 ecsC S EcsC protein family
NHFKFMEO_02609 1.8e-215 ecsB U ABC transporter
NHFKFMEO_02610 4.6e-137 ecsA V transporter (ATP-binding protein)
NHFKFMEO_02611 4.7e-81 hit FG COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
NHFKFMEO_02612 8.4e-204 serC 2.6.1.52 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NHFKFMEO_02613 3.6e-80 trpP S Tryptophan transporter TrpP
NHFKFMEO_02614 7e-39 yhaH S YtxH-like protein
NHFKFMEO_02615 1e-113 hpr K Negative regulator of protease production and sporulation
NHFKFMEO_02616 1.3e-54 yhaI S Protein of unknown function (DUF1878)
NHFKFMEO_02617 8.7e-90 yhaK S Putative zincin peptidase
NHFKFMEO_02618 1.9e-121 prsA 5.2.1.8 M plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins
NHFKFMEO_02619 1.6e-21 yhaL S Sporulation protein YhaL
NHFKFMEO_02620 1.5e-177 yhaM L Shows a 3'-5' exoribonuclease activity
NHFKFMEO_02621 0.0 yhaN L AAA domain
NHFKFMEO_02622 2.2e-224 yhaO L DNA repair exonuclease
NHFKFMEO_02623 4.2e-215 yhaP CP COG1668 ABC-type Na efflux pump, permease component
NHFKFMEO_02624 1.2e-166 yhaQ S ABC transporter, ATP-binding protein
NHFKFMEO_02625 1.1e-26 S YhzD-like protein
NHFKFMEO_02626 2.3e-131 yhaR 5.3.3.18 I enoyl-CoA hydratase
NHFKFMEO_02628 7.8e-88 yhaT P regulatory, ligand-binding protein related to C-terminal domains of K channels
NHFKFMEO_02629 1.7e-208 yhaU P COG0475 Kef-type K transport systems, membrane components
NHFKFMEO_02630 3.9e-292 hemZ H coproporphyrinogen III oxidase
NHFKFMEO_02631 4.3e-142 yhaX S haloacid dehalogenase-like hydrolase
NHFKFMEO_02632 1.5e-205 yhaZ L DNA alkylation repair enzyme
NHFKFMEO_02633 9.5e-48 yheA S Belongs to the UPF0342 family
NHFKFMEO_02634 1.8e-201 yheB S Belongs to the UPF0754 family
NHFKFMEO_02635 4.3e-216 yheC HJ YheC/D like ATP-grasp
NHFKFMEO_02636 1.6e-268 gshB 6.3.2.2, 6.3.2.3 HJ YheC/D like ATP-grasp
NHFKFMEO_02637 1.3e-36 yheE S Family of unknown function (DUF5342)
NHFKFMEO_02638 6.3e-28 sspB S spore protein
NHFKFMEO_02639 7.6e-109 yheG GM NAD(P)H-binding
NHFKFMEO_02640 0.0 yheH V COG1132 ABC-type multidrug transport system, ATPase and permease components
NHFKFMEO_02641 0.0 yheI V COG1132 ABC-type multidrug transport system, ATPase and permease components
NHFKFMEO_02642 5.4e-82 nhaX T Belongs to the universal stress protein A family
NHFKFMEO_02643 3.3e-229 nhaC C Na H antiporter
NHFKFMEO_02644 1.2e-152 dat 2.6.1.21 E Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha- keto acid in the first half-reaction
NHFKFMEO_02645 5.3e-137 yheN G deacetylase
NHFKFMEO_02646 4.2e-138 cobB K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form
NHFKFMEO_02647 1.6e-202 yhdY M Mechanosensitive ion channel
NHFKFMEO_02649 2.3e-133 yhdW 3.1.4.46 C glycerophosphoryl diester phosphodiesterase
NHFKFMEO_02650 4.3e-65 crcB D Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NHFKFMEO_02651 4.9e-44 crcB D Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NHFKFMEO_02652 2.1e-244 corC1 P COG1253 Hemolysins and related proteins containing CBS domains
NHFKFMEO_02653 8.8e-223 yhdR 2.6.1.1 E Aminotransferase
NHFKFMEO_02654 4.1e-74 cueR K transcriptional
NHFKFMEO_02655 3.1e-240 corC1 S COG1253 Hemolysins and related proteins containing CBS domains
NHFKFMEO_02656 3e-110 plsC 2.3.1.51 I Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family
NHFKFMEO_02657 2.4e-189 yhdN C Aldo keto reductase
NHFKFMEO_02658 5.5e-86 sigM K Belongs to the sigma-70 factor family. ECF subfamily
NHFKFMEO_02659 6.6e-201 yhdL S Sigma factor regulator N-terminal
NHFKFMEO_02660 8.1e-45 yhdK S Sigma-M inhibitor protein
NHFKFMEO_02661 2e-76 BH1582 K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
NHFKFMEO_02662 7.2e-272 ydeL K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
NHFKFMEO_02663 1.3e-241 yhdH S Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
NHFKFMEO_02664 3.4e-250 yhdG E amino acid
NHFKFMEO_02665 2.7e-160 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
NHFKFMEO_02666 1.7e-204 citA 2.3.3.1 C Belongs to the citrate synthase family
NHFKFMEO_02667 3.8e-162 citR K Transcriptional regulator
NHFKFMEO_02668 9.4e-141 lytE 3.5.1.28 CBM50 M COG1388 FOG LysM repeat
NHFKFMEO_02669 6.4e-257 phoB 3.1.3.1 P Belongs to the alkaline phosphatase family
NHFKFMEO_02670 2.1e-276 ycgB S Stage V sporulation protein R
NHFKFMEO_02671 1.5e-238 ygxB M Conserved TM helix
NHFKFMEO_02672 1e-75 nsrR K Transcriptional regulator
NHFKFMEO_02673 1.3e-186 cwlS 3.5.1.28 CBM50 M COG1388 FOG LysM repeat
NHFKFMEO_02674 1.8e-53 yhdC S Protein of unknown function (DUF3889)
NHFKFMEO_02675 1.2e-38 yhdB S YhdB-like protein
NHFKFMEO_02676 1.9e-84 azr 1.7.1.6 S NADPH-dependent FMN reductase
NHFKFMEO_02677 2e-112 yhcZ K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
NHFKFMEO_02678 1.4e-212 yhcY 2.7.13.3 T Histidine kinase
NHFKFMEO_02679 0.0 pmmB 5.4.2.2, 5.4.2.8 G Phosphoglucomutase
NHFKFMEO_02680 0.0 glpD 1.1.5.3 C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NHFKFMEO_02681 4.6e-293 glpK 2.7.1.30 C Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NHFKFMEO_02682 1.9e-152 glpF G Belongs to the MIP aquaporin (TC 1.A.8) family
NHFKFMEO_02683 2e-103 glpP K Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
NHFKFMEO_02684 5.4e-261 yhxA E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NHFKFMEO_02685 4.6e-304 yhcX 3.5.1.3 K Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
NHFKFMEO_02686 1e-119 yhcW 5.4.2.6 S hydrolase
NHFKFMEO_02687 9.9e-68 yhcV S COG0517 FOG CBS domain
NHFKFMEO_02688 9.3e-68 yhcU S Family of unknown function (DUF5365)
NHFKFMEO_02689 1.3e-170 rluA 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
NHFKFMEO_02690 1.7e-100 yhcS 3.4.22.70 M COG3764 Sortase (surface protein transpeptidase)
NHFKFMEO_02691 0.0 yhcR 3.1.3.5, 3.1.31.1 F Belongs to the 5'-nucleotidase family
NHFKFMEO_02692 5.2e-100 yhcQ M Spore coat protein
NHFKFMEO_02693 7.3e-167 yhcP
NHFKFMEO_02694 1.3e-67 yhcN S Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
NHFKFMEO_02695 2e-41 yhcM
NHFKFMEO_02696 1.2e-49 K Transcriptional regulator PadR-like family
NHFKFMEO_02697 1.1e-77 S Protein of unknown function (DUF2812)
NHFKFMEO_02698 6.3e-220 ydjN U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
NHFKFMEO_02699 1.9e-195 yhcK 2.7.7.65 T COG2199 FOG GGDEF domain
NHFKFMEO_02700 5.2e-153 metQ M Belongs to the nlpA lipoprotein family
NHFKFMEO_02701 1e-30 cspB K Cold-shock protein
NHFKFMEO_02702 3.9e-165 yhcI S COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
NHFKFMEO_02703 6.5e-165 yhcH V ABC transporter, ATP-binding protein
NHFKFMEO_02704 4.4e-121 yhcG V ABC transporter, ATP-binding protein
NHFKFMEO_02705 1.5e-59 yhcF K Transcriptional regulator
NHFKFMEO_02706 3.5e-55
NHFKFMEO_02707 2.8e-37 yhcC
NHFKFMEO_02708 1e-98 yhcB 1.6.5.2 S Belongs to the WrbA family
NHFKFMEO_02709 3.1e-271 yhcA EGP Major facilitator Superfamily
NHFKFMEO_02710 3.1e-97 yhbJ V COG1566 Multidrug resistance efflux pump
NHFKFMEO_02711 2.2e-76 yhbI K DNA-binding transcription factor activity
NHFKFMEO_02712 2.5e-225 yhbH S Belongs to the UPF0229 family
NHFKFMEO_02713 0.0 prkA T Ser protein kinase
NHFKFMEO_02714 8.5e-72 yhbF M COG1664 Integral membrane protein CcmA involved in cell shape determination
NHFKFMEO_02715 6.6e-64 yhbE M COG1664 Integral membrane protein CcmA involved in cell shape determination
NHFKFMEO_02716 6e-109 yhbD K Protein of unknown function (DUF4004)
NHFKFMEO_02717 9e-86 trmL 2.1.1.207 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
NHFKFMEO_02718 2.4e-175 yhbB S Putative amidase domain
NHFKFMEO_02719 2.3e-223 queG 1.17.99.6 C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NHFKFMEO_02720 2.3e-113 yhzB S B3/4 domain
NHFKFMEO_02722 4.4e-29 K Transcriptional regulator
NHFKFMEO_02723 2.6e-77 ygaO
NHFKFMEO_02724 6e-42 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NHFKFMEO_02726 3.1e-217 ssuD 1.14.14.5 C Catalyzes the desulfonation of aliphatic sulfonates
NHFKFMEO_02727 1.5e-147 ssuC P COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component
NHFKFMEO_02728 4.3e-170 ssuA M Sulfonate ABC transporter
NHFKFMEO_02729 3.9e-146 ssuB P COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component
NHFKFMEO_02730 7.9e-290 katA 1.11.1.6 P serves to protect cells from the toxic effects of hydrogen peroxide
NHFKFMEO_02732 2.2e-262 ygaK C Berberine and berberine like
NHFKFMEO_02733 0.0 thiC 4.1.99.17 H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NHFKFMEO_02734 1.6e-131 pepE 3.4.11.2, 3.4.13.21 E Belongs to the peptidase S51 family
NHFKFMEO_02735 1.2e-26
NHFKFMEO_02736 2.7e-143 spo0M S COG4326 Sporulation control protein
NHFKFMEO_02740 2e-08
NHFKFMEO_02746 1.3e-63 hxlR K transcriptional
NHFKFMEO_02747 5.2e-105 hxlA 4.1.2.43 G 3-hexulose-6-phosphate synthase
NHFKFMEO_02748 3e-96 hxlB 4.1.2.43, 5.3.1.27 G SIS domain
NHFKFMEO_02749 1.5e-186 tlpC 2.7.13.3 NT chemotaxis protein
NHFKFMEO_02750 8.6e-70 nucA M Deoxyribonuclease NucA/NucB
NHFKFMEO_02751 6.5e-69 nin S Competence protein J (ComJ)
NHFKFMEO_02752 7.5e-293 yckE 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
NHFKFMEO_02753 6e-121 S AAA domain
NHFKFMEO_02754 9.3e-24
NHFKFMEO_02755 5.7e-39 K MarR family
NHFKFMEO_02756 7.8e-52 yckD S Protein of unknown function (DUF2680)
NHFKFMEO_02757 3.6e-47 yckC S membrane
NHFKFMEO_02758 5.2e-132 yckB ET COG0834 ABC-type amino acid transport signal transduction systems, periplasmic component domain
NHFKFMEO_02759 2.4e-116 yecS P COG0765 ABC-type amino acid transport system, permease component
NHFKFMEO_02760 2.8e-224 yciC S GTPases (G3E family)
NHFKFMEO_02761 7e-92 yciB M ErfK YbiS YcfS YnhG
NHFKFMEO_02762 4.2e-172 folE2 3.5.4.16 S Converts GTP to 7,8-dihydroneopterin triphosphate
NHFKFMEO_02763 1.4e-220 nasA P COG2223 Nitrate nitrite transporter
NHFKFMEO_02764 0.0 nirB 1.7.1.15 C Assimilatory nitrate reductase (electron transfer subunit)
NHFKFMEO_02765 0.0 nasC C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
NHFKFMEO_02766 0.0 nirB 1.7.1.15 C Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NHFKFMEO_02767 4.6e-57 nirD 1.7.1.15 P Nitrite reductase
NHFKFMEO_02768 6e-282 cobA 2.1.1.107, 4.2.1.75 H Belongs to the precorrin methyltransferase family
NHFKFMEO_02769 1.1e-192 ycgT 1.18.1.2, 1.19.1.1 C Ferredoxin--NADP reductase
NHFKFMEO_02770 5e-159 I alpha/beta hydrolase fold
NHFKFMEO_02771 1.2e-139 ycgR S permeases
NHFKFMEO_02772 2.2e-146 ycgQ S membrane
NHFKFMEO_02773 1.6e-227 ycgP QT COG2508 Regulator of polyketide synthase expression
NHFKFMEO_02774 9e-248 putP E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NHFKFMEO_02775 7.3e-294 rocA 1.2.1.88, 1.5.5.2 C Belongs to the aldehyde dehydrogenase family. RocA subfamily
NHFKFMEO_02776 5.1e-170 ycgM E Proline dehydrogenase
NHFKFMEO_02777 2.9e-145 ycgL S Predicted nucleotidyltransferase
NHFKFMEO_02778 3.6e-182 cah 3.1.1.41 Q Acetyl xylan esterase (AXE1)
NHFKFMEO_02779 5.1e-176 oxyR3 K LysR substrate binding domain
NHFKFMEO_02780 3.6e-145 yafE Q ubiE/COQ5 methyltransferase family
NHFKFMEO_02781 3e-104 aroK 2.7.1.71, 4.2.3.4 F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NHFKFMEO_02783 1.2e-106 tmrB S AAA domain
NHFKFMEO_02784 1.5e-149 nadE 6.3.1.5 H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
NHFKFMEO_02785 2.4e-112 ycgI S Domain of unknown function (DUF1989)
NHFKFMEO_02786 1.6e-249 ycgH E COG1113 Gamma-aminobutyrate permease and related permeases
NHFKFMEO_02787 1.3e-150 yqcI S YqcI/YcgG family
NHFKFMEO_02788 6.8e-113 ycgF E Lysine exporter protein LysE YggA
NHFKFMEO_02789 3.4e-77 emrR K helix_turn_helix multiple antibiotic resistance protein
NHFKFMEO_02790 3.6e-261 mdr EGP Major facilitator Superfamily
NHFKFMEO_02791 1.5e-289 lctP C L-lactate permease
NHFKFMEO_02792 1.2e-182 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
NHFKFMEO_02793 0.0 amyE 3.2.1.1 GH13 G alpha-amylase
NHFKFMEO_02794 1.2e-80 ycgB
NHFKFMEO_02795 8.7e-257 ycgA S Membrane
NHFKFMEO_02796 1.4e-217 amhX S amidohydrolase
NHFKFMEO_02797 5.3e-164 opuAC E glycine betaine
NHFKFMEO_02798 1.3e-127 opuAB P glycine betaine
NHFKFMEO_02799 4.3e-228 proV 3.6.3.32 E glycine betaine
NHFKFMEO_02800 6.1e-45 K helix_turn_helix, Arsenical Resistance Operon Repressor
NHFKFMEO_02801 7.9e-208 yceJ EGP Uncharacterised MFS-type transporter YbfB
NHFKFMEO_02802 1.4e-215 naiP P Uncharacterised MFS-type transporter YbfB
NHFKFMEO_02803 2e-192 yceH P Belongs to the TelA family
NHFKFMEO_02804 0.0 yceG S Putative component of 'biosynthetic module'
NHFKFMEO_02805 1.4e-136 terC P Protein of unknown function (DUF475)
NHFKFMEO_02806 4.6e-108 yceE T proteins involved in stress response, homologs of TerZ and
NHFKFMEO_02807 2.8e-105 yceD T proteins involved in stress response, homologs of TerZ and
NHFKFMEO_02808 5.6e-109 yceC 3.5.4.33 T proteins involved in stress response, homologs of TerZ and
NHFKFMEO_02809 6.1e-185 yceB C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NHFKFMEO_02810 1.7e-135 adcB P COG1108 ABC-type Mn2 Zn2 transport systems, permease components
NHFKFMEO_02811 2.5e-132 adcC P 'COG1121 ABC-type Mn Zn transport systems, ATPase component'
NHFKFMEO_02812 4.3e-167 adcA P Belongs to the bacterial solute-binding protein 9 family
NHFKFMEO_02813 0.0 ycdG 3.2.1.10 GH13 G COG0366 Glycosidases
NHFKFMEO_02814 1.2e-138 IQ Enoyl-(Acyl carrier protein) reductase
NHFKFMEO_02815 1.2e-173 S response regulator aspartate phosphatase
NHFKFMEO_02816 1.6e-93 cwlK M D-alanyl-D-alanine carboxypeptidase
NHFKFMEO_02817 1.5e-259 ycdC K Belongs to the sigma-70 factor family. ECF subfamily
NHFKFMEO_02818 7.2e-272 ycdB K Belongs to the sigma-70 factor family. ECF subfamily
NHFKFMEO_02819 6.6e-177 ycdA S Domain of unknown function (DUF5105)
NHFKFMEO_02820 1.6e-174 yccK C Aldo keto reductase
NHFKFMEO_02821 7.9e-200 natB CP ABC-2 family transporter protein
NHFKFMEO_02822 5.9e-132 natA 3.6.3.7 CP ATPases associated with a variety of cellular activities
NHFKFMEO_02823 1.2e-126 lytR_2 T LytTr DNA-binding domain
NHFKFMEO_02824 2.9e-160 2.7.13.3 T GHKL domain
NHFKFMEO_02825 3.6e-199 yccF K DNA-templated transcriptional preinitiation complex assembly
NHFKFMEO_02826 4.6e-56 S RDD family
NHFKFMEO_02827 5.6e-115 lip 3.1.1.3 S acetyltransferases and hydrolases with the alpha beta hydrolase fold
NHFKFMEO_02828 2.4e-201 ansB 3.5.1.1 EJ COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D
NHFKFMEO_02829 4.8e-102 yxaF K Transcriptional regulator
NHFKFMEO_02830 7.9e-226 lmrB EGP the major facilitator superfamily
NHFKFMEO_02831 6.6e-204 ycbU E Selenocysteine lyase
NHFKFMEO_02832 2.9e-119 pcp 3.4.19.3 O Removes 5-oxoproline from various penultimate amino acid residues except L-proline
NHFKFMEO_02833 2.6e-124 tatC U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NHFKFMEO_02834 5e-28 tatA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
NHFKFMEO_02835 0.0 phoD 3.1.3.1 P COG3540 Phosphodiesterase alkaline phosphatase D
NHFKFMEO_02836 1.2e-134 ycbR T vWA found in TerF C terminus
NHFKFMEO_02837 1.3e-78 sleB 3.5.1.28 M Cell wall
NHFKFMEO_02838 4.1e-52 ycbP S Protein of unknown function (DUF2512)
NHFKFMEO_02839 1.5e-113 S ABC-2 family transporter protein
NHFKFMEO_02840 4.1e-167 ycbN V ABC transporter, ATP-binding protein
NHFKFMEO_02841 9.9e-169 T PhoQ Sensor
NHFKFMEO_02842 2.2e-125 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
NHFKFMEO_02843 7.5e-169 eamA1 EG spore germination
NHFKFMEO_02844 4.4e-24 rtpA K Tryptophan RNA-binding attenuator protein inhibitory protein
NHFKFMEO_02845 1.8e-178 ycbJ S Macrolide 2'-phosphotransferase
NHFKFMEO_02846 1.1e-297 garD 4.2.1.42, 4.2.1.7 G Altronate
NHFKFMEO_02847 1.9e-124 ycbG K FCD
NHFKFMEO_02848 1e-267 gudD 4.2.1.40 M Belongs to the mandelate racemase muconate lactonizing enzyme family
NHFKFMEO_02849 4.5e-255 gudP G COG0477 Permeases of the major facilitator superfamily
NHFKFMEO_02850 4.5e-272 ycbD C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
NHFKFMEO_02851 2.7e-174 kdgD 4.2.1.41 EM 5-dehydro-4-deoxyglucarate dehydratase activity
NHFKFMEO_02852 9e-170 glnL T Regulator
NHFKFMEO_02853 1.5e-229 phoQ 2.7.13.3 T Histidine kinase
NHFKFMEO_02854 3.8e-187 glsA 3.5.1.2 E Belongs to the glutaminase family
NHFKFMEO_02855 2.8e-255 agcS E Sodium alanine symporter
NHFKFMEO_02856 1e-181 mmuM 1.5.1.20, 2.1.1.10 H homocysteine
NHFKFMEO_02857 1.4e-259 mmuP E amino acid
NHFKFMEO_02858 4.6e-202 ilvE 2.6.1.42 E Branched-chain amino acid aminotransferase
NHFKFMEO_02860 4.9e-128 K UTRA
NHFKFMEO_02861 2e-135 nagB 3.1.1.31, 3.5.99.6 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
NHFKFMEO_02862 0.0 ptsG 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
NHFKFMEO_02863 6.4e-216 gltP C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
NHFKFMEO_02864 3.3e-191 yceA S Belongs to the UPF0176 family
NHFKFMEO_02865 6.4e-09 S Erythromycin esterase
NHFKFMEO_02866 2e-45 ybfN
NHFKFMEO_02867 6.9e-147 psd 4.1.1.65 I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)
NHFKFMEO_02868 2.7e-85 ybfM S SNARE associated Golgi protein
NHFKFMEO_02869 3.2e-95 pssA 2.7.8.8 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NHFKFMEO_02870 1e-167 S Alpha/beta hydrolase family
NHFKFMEO_02872 2e-177 mpr 3.4.21.19 M Belongs to the peptidase S1B family
NHFKFMEO_02873 1.7e-210 purT 2.1.2.2 F Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
NHFKFMEO_02874 2e-144 msmR K AraC-like ligand binding domain
NHFKFMEO_02875 1.1e-159 ybfH EG EamA-like transporter family
NHFKFMEO_02876 3e-240 ybfG 3.2.1.132 M Domain of unknown function (DUF1906)
NHFKFMEO_02877 4.1e-150 ybfG 3.2.1.132 M Domain of unknown function (DUF1906)
NHFKFMEO_02880 3.5e-222 ybfB G COG0477 Permeases of the major facilitator superfamily
NHFKFMEO_02881 2.2e-168 ybfA 3.4.15.5 K FR47-like protein
NHFKFMEO_02882 1.5e-34 S Protein of unknown function (DUF2651)
NHFKFMEO_02883 7.3e-258 glpT G -transporter
NHFKFMEO_02884 1.9e-161 glpQ 3.1.4.46 C glycerophosphoryl diester phosphodiesterase
NHFKFMEO_02885 4.1e-49 M PFAM Glycosyl transferase family 2
NHFKFMEO_02886 1.8e-290 ybeC E amino acid
NHFKFMEO_02887 4.9e-41 ybyB
NHFKFMEO_02888 2.7e-246 cypC 1.11.2.4, 1.14.14.1 Q Cytochrome P450
NHFKFMEO_02889 4.4e-149 ybxI 3.5.2.6 V beta-lactamase
NHFKFMEO_02890 4.9e-30 ybxH S Family of unknown function (DUF5370)
NHFKFMEO_02891 3.7e-38 csgA S Sigma-G-dependent sporulation-specific SASP protein
NHFKFMEO_02892 1.5e-258 yifK E COG1113 Gamma-aminobutyrate permease and related permeases
NHFKFMEO_02893 1.7e-213 ybdO S Domain of unknown function (DUF4885)
NHFKFMEO_02894 1.3e-151 ybdN
NHFKFMEO_02895 3.7e-137 KLT Protein tyrosine kinase
NHFKFMEO_02897 1.2e-167 T His Kinase A (phospho-acceptor) domain
NHFKFMEO_02898 2.9e-122 T Transcriptional regulatory protein, C terminal
NHFKFMEO_02899 1.3e-179 S hydrolases or acyltransferases (alpha beta hydrolase superfamily)
NHFKFMEO_02900 3.7e-78 txn CO Thioredoxin-like
NHFKFMEO_02901 7.8e-91 C HEAT repeats
NHFKFMEO_02902 8.4e-246 skfF S ABC transporter
NHFKFMEO_02903 8e-134 skfE V ABC transporter
NHFKFMEO_02904 4.6e-277 V CAAX protease self-immunity
NHFKFMEO_02905 9.1e-239 J 4Fe-4S single cluster domain
NHFKFMEO_02907 7.2e-201 ybcL EGP Major facilitator Superfamily
NHFKFMEO_02908 5.1e-50 ybzH K Helix-turn-helix domain
NHFKFMEO_02909 4.7e-61 ybcI S Uncharacterized conserved protein (DUF2294)
NHFKFMEO_02910 5.6e-46
NHFKFMEO_02912 4.7e-91 can 4.2.1.1 P carbonic anhydrase
NHFKFMEO_02913 0.0 ybcC S Belongs to the UPF0753 family
NHFKFMEO_02914 1.8e-276 ndhF 1.6.5.3 CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit
NHFKFMEO_02915 1.2e-97 ogt 2.1.1.63, 3.2.2.21 L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NHFKFMEO_02916 5.8e-120 adaA 3.2.2.21 K Transcriptional regulator
NHFKFMEO_02917 1.5e-174 alkA 3.2.2.21 L COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
NHFKFMEO_02918 0.0 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
NHFKFMEO_02919 3.5e-252 glmM 5.4.2.10 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NHFKFMEO_02920 1.5e-224 ybbR S protein conserved in bacteria
NHFKFMEO_02921 2.7e-146 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NHFKFMEO_02922 1.8e-102 rsiW K Is the anti-sigma factor for SigW. The presence of RsiW leads to the inactivation of SigW, and its proteolytic destruction to sigma-W activation
NHFKFMEO_02923 2.5e-98 sigW K Belongs to the sigma-70 factor family. ECF subfamily
NHFKFMEO_02924 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
NHFKFMEO_02925 0.0 6.3.2.14 Q amino acid activation for nonribosomal peptide biosynthetic process
NHFKFMEO_02926 1.1e-63 yngL S Protein of unknown function (DUF1360)
NHFKFMEO_02927 1.7e-303 yngK T Glycosyl hydrolase-like 10
NHFKFMEO_02928 1.2e-208 yngJ 1.3.8.1, 1.3.99.12 I acyl-CoA dehydrogenase
NHFKFMEO_02929 0.0 yngI IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
NHFKFMEO_02930 4.3e-250 yngH 6.3.4.14, 6.4.1.2, 6.4.1.3, 6.4.1.4 I Biotin carboxylase
NHFKFMEO_02931 1.5e-30 pycB 2.3.1.12, 6.4.1.1 I Biotin carboxyl carrier protein
NHFKFMEO_02932 1.3e-165 mvaB 4.1.3.4, 6.4.1.4 E Hydroxymethylglutaryl-CoA lyase
NHFKFMEO_02933 7.1e-136 yngF 4.2.1.17 I Belongs to the enoyl-CoA hydratase isomerase family
NHFKFMEO_02934 1.7e-287 yngE 2.1.3.15, 6.4.1.3 I COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
NHFKFMEO_02935 1.1e-231 nrnB S phosphohydrolase (DHH superfamily)
NHFKFMEO_02936 6.1e-103 yngC S membrane-associated protein
NHFKFMEO_02937 5.9e-163 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
NHFKFMEO_02938 6.5e-78 yngA S membrane
NHFKFMEO_02939 2.3e-295 xynD3 3.2.1.55 CBM6,GH43 G Belongs to the glycosyl hydrolase 43 family
NHFKFMEO_02940 1.8e-250 xynC 3.2.1.136 GH5 M Belongs to the glycosyl hydrolase 30 family
NHFKFMEO_02942 9.9e-296 bglC5 3.2.1.4 GH5,GH9 G PFAM glycoside hydrolase family 5
NHFKFMEO_02943 1.8e-251 agcS E Sodium alanine symporter
NHFKFMEO_02944 1.3e-57 ynfC
NHFKFMEO_02945 2.3e-12
NHFKFMEO_02946 0.0 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
NHFKFMEO_02947 0.0 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
NHFKFMEO_02948 8.6e-69 yccU S CoA-binding protein
NHFKFMEO_02949 5e-94 plsY 2.3.1.15, 3.5.1.104 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
NHFKFMEO_02950 4.1e-49 yneR S Belongs to the HesB IscA family
NHFKFMEO_02951 1.7e-53 yneQ
NHFKFMEO_02952 2e-73 yneP S Thioesterase-like superfamily
NHFKFMEO_02953 3.9e-35 tlp S Belongs to the Tlp family
NHFKFMEO_02954 3.1e-08 sspN S Small acid-soluble spore protein N family
NHFKFMEO_02956 2.7e-91 yneN CO alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NHFKFMEO_02957 0.0 acnA 4.2.1.3 C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NHFKFMEO_02958 2.2e-14 sspO S Belongs to the SspO family
NHFKFMEO_02959 3.9e-19 sspP S Belongs to the SspP family
NHFKFMEO_02960 1.2e-64 hspX O Spore coat protein
NHFKFMEO_02961 4.2e-74 yneK S Protein of unknown function (DUF2621)
NHFKFMEO_02962 5.1e-76 yneJ O COG4846 Membrane protein involved in cytochrome C biogenesis
NHFKFMEO_02963 7.2e-59 cheB 3.1.1.61, 3.5.1.44 T cheY-homologous receiver domain
NHFKFMEO_02964 7.1e-127 ccdA O cytochrome c biogenesis protein
NHFKFMEO_02965 7.5e-14 ynzD S Spo0E like sporulation regulatory protein
NHFKFMEO_02966 1.8e-28 yneF S UPF0154 protein
NHFKFMEO_02967 2.2e-81 yneE S Sporulation inhibitor of replication protein sirA
NHFKFMEO_02968 0.0 tkt 2.2.1.1 G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NHFKFMEO_02969 1.3e-32 ynzC S UPF0291 protein
NHFKFMEO_02970 4.5e-112 yneB L resolvase
NHFKFMEO_02971 9.9e-49 yneA D Inhibits cell division during the SOS response. Affects a later stage of the cell division protein assembly, after the assembly of the Z ring, by probably suppressing recruitment of FtsL and or DivIC to the division machinery
NHFKFMEO_02972 2.6e-109 lexA 3.4.21.88 K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NHFKFMEO_02973 2.4e-74 fosB 2.5.1.18 H Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor
NHFKFMEO_02974 5.8e-74 yndM S Protein of unknown function (DUF2512)
NHFKFMEO_02975 1.4e-136 yndL S Replication protein
NHFKFMEO_02977 0.0 yndJ S YndJ-like protein
NHFKFMEO_02978 2.6e-117 yndH S Domain of unknown function (DUF4166)
NHFKFMEO_02979 7.7e-154 yndG S DoxX-like family
NHFKFMEO_02980 4.2e-220 gerLC S Spore germination protein
NHFKFMEO_02981 4.5e-197 gerAB U Spore germination
NHFKFMEO_02982 5.8e-283 gerAA EG Spore germination protein
NHFKFMEO_02985 5.2e-80 yndB S Activator of Hsp90 ATPase homolog 1-like protein
NHFKFMEO_02986 1.8e-71
NHFKFMEO_02987 7.9e-25 tatA U protein secretion
NHFKFMEO_02990 1.3e-134 S Domain of unknown function, YrpD
NHFKFMEO_02992 9.5e-163 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NHFKFMEO_02995 5.2e-15
NHFKFMEO_02996 1.4e-77 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F Deoxyuridine 5'-triphosphate
NHFKFMEO_02998 4.5e-219 alr 5.1.1.1 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NHFKFMEO_02999 1.4e-254 iolT EGP Major facilitator Superfamily
NHFKFMEO_03000 1.7e-111 yokF 3.1.31.1 L RNA catabolic process
NHFKFMEO_03001 1.3e-290 xylB 2.7.1.12, 2.7.1.17, 2.7.1.5 G xylulose kinase
NHFKFMEO_03002 6.4e-262 xylA 5.3.1.5 G Belongs to the xylose isomerase family
NHFKFMEO_03003 1.2e-213 xylR GK ROK family
NHFKFMEO_03004 0.0 xynB 3.2.1.37 GH43 G Belongs to the glycosyl hydrolase 43 family
NHFKFMEO_03005 1e-254 xynT G MFS/sugar transport protein
NHFKFMEO_03006 8.7e-81 XK27_05370 5.3.1.24 E phosphoribosylanthranilate isomerase activity
NHFKFMEO_03008 8.6e-15 ynaF
NHFKFMEO_03009 6.4e-111 ynaE S Domain of unknown function (DUF3885)
NHFKFMEO_03010 5.5e-20 K Cro/C1-type HTH DNA-binding domain
NHFKFMEO_03011 4.7e-08 S Uncharacterised protein family (UPF0715)
NHFKFMEO_03012 3.6e-75 S CAAX protease self-immunity
NHFKFMEO_03014 2e-97 ynaD J Acetyltransferase (GNAT) domain
NHFKFMEO_03015 4.1e-11 S Protein of unknown function (DUF1433)
NHFKFMEO_03016 3.1e-113 ynaC
NHFKFMEO_03017 8.9e-90 G SMI1-KNR4 cell-wall
NHFKFMEO_03018 2.1e-16
NHFKFMEO_03019 1.6e-31
NHFKFMEO_03020 1.1e-09
NHFKFMEO_03021 7e-261 glnA 6.3.1.2 E glutamine synthetase
NHFKFMEO_03022 1.1e-68 glnR K transcriptional
NHFKFMEO_03023 4.8e-243 ynbB 4.4.1.1 P COG4100 Cystathionine beta-lyase family protein involved in aluminum resistance
NHFKFMEO_03024 7.9e-230 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NHFKFMEO_03025 1.7e-176 spoVK O stage V sporulation protein K
NHFKFMEO_03026 2e-114 cwlC 3.5.1.28 M n-acetylmuramoyl-L-alanine amidase
NHFKFMEO_03027 2e-109 ymaB
NHFKFMEO_03028 4.5e-188 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NHFKFMEO_03029 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NHFKFMEO_03030 1.9e-49 nrdI 1.17.4.1 F Probably involved in ribonucleotide reductase function
NHFKFMEO_03031 4.5e-22 ymzA
NHFKFMEO_03032 3.1e-22
NHFKFMEO_03033 1.9e-33 hfq J RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs
NHFKFMEO_03034 2.1e-174 miaA 2.5.1.75 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NHFKFMEO_03035 2.1e-46 ymaF S YmaF family
NHFKFMEO_03037 2.1e-49 ebrA P Small Multidrug Resistance protein
NHFKFMEO_03038 1.4e-54 ebrB P COG2076 Membrane transporters of cations and cationic drugs
NHFKFMEO_03039 1.6e-79 ymaD O redox protein, regulator of disulfide bond formation
NHFKFMEO_03040 2.1e-126 ymaC S Replication protein
NHFKFMEO_03041 1.9e-07 K Transcriptional regulator
NHFKFMEO_03042 4.6e-252 aprX O Belongs to the peptidase S8 family
NHFKFMEO_03043 2.1e-162 ymaE S Metallo-beta-lactamase superfamily
NHFKFMEO_03044 1.2e-61 ymzB
NHFKFMEO_03045 3.7e-232 cypA C Cytochrome P450
NHFKFMEO_03046 0.0 pks13 HQ Beta-ketoacyl synthase
NHFKFMEO_03047 0.0 dhbF IQ polyketide synthase
NHFKFMEO_03048 0.0 pfaA 4.1.1.35 GT4 IQ polyketide synthase
NHFKFMEO_03049 0.0 pfaA Q Polyketide synthase of type I
NHFKFMEO_03050 0.0 rhiB IQ polyketide synthase
NHFKFMEO_03051 3e-136 pksI I Belongs to the enoyl-CoA hydratase isomerase family
NHFKFMEO_03052 7.7e-143 pksH 4.2.1.18 I enoyl-CoA hydratase
NHFKFMEO_03053 3.9e-245 pksG 2.3.3.10 I synthase
NHFKFMEO_03054 1.7e-237 pksF 2.3.1.179, 2.3.1.41 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
NHFKFMEO_03055 1.4e-37 acpK IQ Phosphopantetheine attachment site
NHFKFMEO_03056 0.0 fabD 1.13.12.16, 2.3.1.39 I malonyl CoA-acyl carrier protein transacylase
NHFKFMEO_03057 2.7e-185 pksD Q Acyl transferase domain
NHFKFMEO_03058 4.1e-161 fabD 2.3.1.39 I malonyl CoA-acyl carrier protein transacylase
NHFKFMEO_03059 4.2e-129 pksB 3.1.2.6 S Polyketide biosynthesis
NHFKFMEO_03060 1.3e-108 pksA K Transcriptional regulator
NHFKFMEO_03061 3.5e-97 ymcC S Membrane
NHFKFMEO_03063 5.1e-70 S Regulatory protein YrvL
NHFKFMEO_03064 0.0 mutL L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NHFKFMEO_03065 0.0 mutS L that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NHFKFMEO_03066 2.2e-88 cotE S Spore coat protein
NHFKFMEO_03067 9.2e-69 ymcA 3.6.3.21 S Belongs to the UPF0342 family
NHFKFMEO_03068 1.7e-295 miaB 2.8.4.3 J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NHFKFMEO_03069 2.5e-217 kbl 2.3.1.29, 2.3.1.47 H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide
NHFKFMEO_03070 3.9e-198 tdh 1.1.1.103 C Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate
NHFKFMEO_03071 1.2e-36 spoVS S Stage V sporulation protein S
NHFKFMEO_03072 1.9e-152 ymdB S protein conserved in bacteria
NHFKFMEO_03073 2.1e-224 rny S Endoribonuclease that initiates mRNA decay
NHFKFMEO_03074 3.9e-215 pbpX V Beta-lactamase
NHFKFMEO_03075 8.1e-188 recA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NHFKFMEO_03076 1.3e-235 cinA 3.5.1.42 S Belongs to the CinA family
NHFKFMEO_03077 2.5e-101 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NHFKFMEO_03078 7.3e-116 ymfM S protein conserved in bacteria
NHFKFMEO_03079 2.7e-143 ymfK S Protein of unknown function (DUF3388)
NHFKFMEO_03080 4.8e-41 ymfJ S Protein of unknown function (DUF3243)
NHFKFMEO_03081 7.8e-129 ymfI 1.1.1.100, 1.3.1.28 S Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
NHFKFMEO_03082 1.4e-242 ymfH S zinc protease
NHFKFMEO_03083 2e-233 ymfF S Peptidase M16
NHFKFMEO_03084 3.8e-205 ymfD EGP Major facilitator Superfamily
NHFKFMEO_03085 1.4e-133 ymfC K Transcriptional regulator
NHFKFMEO_03086 0.0 ftsK D Belongs to the FtsK SpoIIIE SftA family
NHFKFMEO_03087 4.4e-32 S YlzJ-like protein
NHFKFMEO_03088 5.3e-133 tepA 3.4.21.92 OU COG0740 Protease subunit of ATP-dependent Clp proteases
NHFKFMEO_03089 1.9e-308 rnjB S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NHFKFMEO_03090 1.4e-156 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NHFKFMEO_03091 1.7e-221 dapG 1.1.1.3, 2.7.2.4 E Belongs to the aspartokinase family
NHFKFMEO_03092 1.2e-191 asd 1.2.1.11 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NHFKFMEO_03093 6.3e-108 spoVFB H Together with DpaA, catalyzes the conversion of dihydrodipicolinate to dipicolinate (DPA)
NHFKFMEO_03094 2.9e-162 spoVFA 1.1.1.29, 1.1.1.399, 1.1.1.95 CH Dipicolinate synthase subunit A
NHFKFMEO_03095 2.6e-42 ymxH S YlmC YmxH family
NHFKFMEO_03096 4.4e-233 pepR S Belongs to the peptidase M16 family
NHFKFMEO_03097 6.1e-182 ylxY 3.5.1.104 G Sporulation protein, polysaccharide deacetylase
NHFKFMEO_03098 0.0 pnp 2.7.7.8 J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
NHFKFMEO_03099 6e-42 rpsO J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NHFKFMEO_03100 1.1e-180 ribF 2.7.1.26, 2.7.7.2 H Belongs to the ribF family
NHFKFMEO_03101 1.5e-172 truB 5.4.99.25 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NHFKFMEO_03102 5e-57 rbfA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NHFKFMEO_03103 3e-44 ylxP S protein conserved in bacteria
NHFKFMEO_03104 0.0 infB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NHFKFMEO_03105 3.1e-47 ylxQ J ribosomal protein
NHFKFMEO_03106 3.4e-32 ylxR K nucleic-acid-binding protein implicated in transcription termination
NHFKFMEO_03107 1.1e-203 nusA K Participates in both transcription termination and antitermination
NHFKFMEO_03108 3.3e-80 rimP S Required for maturation of 30S ribosomal subunits
NHFKFMEO_03109 0.0 polC 2.7.7.7 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NHFKFMEO_03110 0.0 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
NHFKFMEO_03111 7.7e-233 rasP M zinc metalloprotease
NHFKFMEO_03112 4.6e-216 dxr 1.1.1.267 I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
NHFKFMEO_03113 7.7e-138 cdsA 2.7.7.41 S Belongs to the CDS family
NHFKFMEO_03114 8.3e-145 uppS 2.5.1.31 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NHFKFMEO_03115 6.4e-91 frr J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
NHFKFMEO_03116 2.7e-126 pyrH 2.7.4.22 F Catalyzes the reversible phosphorylation of UMP to UDP
NHFKFMEO_03117 6.3e-157 tsf J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NHFKFMEO_03118 1e-131 rpsB J Belongs to the universal ribosomal protein uS2 family
NHFKFMEO_03119 3.1e-76 ylxL
NHFKFMEO_03120 5.6e-138 sigD K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NHFKFMEO_03121 1.1e-86 cheD 3.5.1.44 NT Deamidates glutamine residues to glutamate on methyl- accepting chemotaxis receptors (MCPs). CheD-mediated MCP deamidation is required for productive communication of the conformational signals of the chemoreceptors to the CheA kinase
NHFKFMEO_03122 1.3e-111 cheC NT COG1776 Chemotaxis protein CheC, inhibitor of MCP methylation
NHFKFMEO_03123 2.8e-79 cheW NT COG0835 Chemotaxis signal transduction protein
NHFKFMEO_03124 0.0 cheA 2.7.13.3 NT COG0643 Chemotaxis protein histidine kinase and related kinases
NHFKFMEO_03125 7.5e-197 cheB 3.1.1.61, 3.5.1.44 NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR
NHFKFMEO_03126 4.1e-156 flhG D Belongs to the ParA family
NHFKFMEO_03127 5.2e-201 flhF N Flagellar biosynthesis regulator FlhF
NHFKFMEO_03128 0.0 flhA N Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NHFKFMEO_03129 1.4e-190 flhB N Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NHFKFMEO_03130 3.6e-132 fliR N Flagellar biosynthetic protein FliR
NHFKFMEO_03131 2.2e-36 fliQ N Role in flagellar biosynthesis
NHFKFMEO_03132 1.6e-109 fliP N Plays a role in the flagellum-specific transport system
NHFKFMEO_03133 2.7e-96 fliZ N Flagellar biosynthesis protein, FliO
NHFKFMEO_03134 6.1e-58 cheB 3.1.1.61, 3.5.1.44 T response regulator
NHFKFMEO_03135 4.5e-184 fliN N FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NHFKFMEO_03136 1.9e-181 fliM N One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation
NHFKFMEO_03137 4.6e-49 fliL N Controls the rotational direction of flagella during chemotaxis
NHFKFMEO_03138 8.2e-140 flgG N Flagellar basal body rod
NHFKFMEO_03139 2.3e-72 flgD N Flagellar basal body rod modification protein
NHFKFMEO_03140 5.1e-220 fliK N Flagellar hook-length control protein
NHFKFMEO_03141 2.2e-36 ylxF S MgtE intracellular N domain
NHFKFMEO_03142 1.5e-69 fliJ N Flagellar biosynthesis chaperone
NHFKFMEO_03143 7.2e-242 fliI 3.6.3.14 NU COG1157 Flagellar biosynthesis type III secretory pathway ATPase
NHFKFMEO_03144 2.5e-106 fliH NU COG1317 Flagellar biosynthesis type III secretory pathway protein
NHFKFMEO_03145 2e-178 fliG N One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation
NHFKFMEO_03146 1.6e-254 fliF N The M ring may be actively involved in energy transduction
NHFKFMEO_03147 1.9e-31 fliE N Flagellar hook-basal body
NHFKFMEO_03148 6.9e-75 flgC N Belongs to the flagella basal body rod proteins family
NHFKFMEO_03149 2.3e-63 flgB N Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body
NHFKFMEO_03150 9.2e-136 codY K DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
NHFKFMEO_03151 4.5e-250 hslU O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
NHFKFMEO_03152 4.4e-92 hslV 3.4.25.2 O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
NHFKFMEO_03153 2.5e-169 xerC L tyrosine recombinase XerC
NHFKFMEO_03154 7.4e-247 trmFO 2.1.1.74 J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
NHFKFMEO_03155 0.0 topA 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NHFKFMEO_03156 5e-170 dprA LU Rossmann fold nucleotide-binding protein involved in DNA uptake
NHFKFMEO_03157 1.1e-167 sucD 6.2.1.5 C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NHFKFMEO_03158 3.4e-211 sucC 6.2.1.5 C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
NHFKFMEO_03159 3e-44 ylqH S homolog of the cytoplasmic domain of flagellar protein FhlB
NHFKFMEO_03160 4.3e-287 ylqG
NHFKFMEO_03161 9e-136 rnhB 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NHFKFMEO_03162 2.3e-156 ylqF S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NHFKFMEO_03163 1.4e-56 rplS J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
NHFKFMEO_03164 7.8e-137 trmD 2.1.1.228, 4.6.1.12 J Belongs to the RNA methyltransferase TrmD family
NHFKFMEO_03165 5.3e-95 rimM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NHFKFMEO_03166 6.3e-61 ylqD S YlqD protein
NHFKFMEO_03167 4.5e-36 ylqC S Belongs to the UPF0109 family
NHFKFMEO_03168 1.1e-43 rpsP J Belongs to the bacterial ribosomal protein bS16 family
NHFKFMEO_03169 1e-235 ffh 3.6.5.4 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NHFKFMEO_03170 1.6e-49 ylxM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
NHFKFMEO_03171 3.5e-85
NHFKFMEO_03172 8.8e-176 ftsY U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
NHFKFMEO_03173 0.0 smc D Required for chromosome condensation and partitioning
NHFKFMEO_03174 1.2e-135 rnc 3.1.26.3 J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
NHFKFMEO_03175 2.8e-32 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
NHFKFMEO_03176 1.1e-127 IQ reductase
NHFKFMEO_03177 2.7e-169 fabD 2.3.1.39 I malonyl CoA-acyl carrier protein transacylase
NHFKFMEO_03178 4.3e-178 plsX 2.3.1.15 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
NHFKFMEO_03179 4e-80 fapR 5.3.1.23 K Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism
NHFKFMEO_03180 0.0 recG 3.6.4.12 L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NHFKFMEO_03181 9.3e-156 sdaAA 4.3.1.17 E L-serine dehydratase
NHFKFMEO_03182 1.9e-118 sdaAB 4.3.1.17 E L-serine dehydratase
NHFKFMEO_03183 1.2e-297 yloV S kinase related to dihydroxyacetone kinase
NHFKFMEO_03184 5.5e-59 asp S protein conserved in bacteria
NHFKFMEO_03185 4.2e-26 rpmB J Belongs to the bacterial ribosomal protein bL28 family
NHFKFMEO_03186 6.9e-121 thiN 2.7.6.2 H thiamine pyrophosphokinase
NHFKFMEO_03187 4.2e-118 rpe 5.1.3.1 G Belongs to the ribulose-phosphate 3-epimerase family
NHFKFMEO_03188 3.3e-169 rsgA 3.1.3.100 S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
NHFKFMEO_03189 0.0 prkC 2.7.11.1 KLT serine threonine protein kinase
NHFKFMEO_03190 1.6e-140 stp 3.1.3.16 T phosphatase
NHFKFMEO_03191 5.3e-206 rlmN 2.1.1.192 J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
NHFKFMEO_03192 5.4e-253 sun 2.1.1.176 J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NHFKFMEO_03193 5.2e-173 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NHFKFMEO_03194 6.6e-84 def 2.1.2.9, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
NHFKFMEO_03195 0.0 priA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NHFKFMEO_03196 1.4e-223 coaBC 4.1.1.36, 6.3.2.5 H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NHFKFMEO_03197 2.2e-28 rpoZ 2.7.7.6 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
NHFKFMEO_03198 3.1e-110 gmk 2.7.4.8 F Essential for recycling GMP and indirectly, cGMP
NHFKFMEO_03199 1.5e-40 ylzA S Belongs to the UPF0296 family
NHFKFMEO_03200 3.1e-156 yloC S stress-induced protein
NHFKFMEO_03201 0.0 yloB 3.6.3.8 P COG0474 Cation transport ATPase
NHFKFMEO_03202 0.0 FbpA K RNA-binding protein homologous to eukaryotic snRNP
NHFKFMEO_03203 8.2e-82 cysG 1.3.1.76, 4.99.1.4 H Siroheme synthase
NHFKFMEO_03204 2e-146 cbiX 4.99.1.3, 4.99.1.4, 5.4.99.60, 5.4.99.61 S Sirohydrochlorin ferrochelatase
NHFKFMEO_03205 2.2e-145 hemD 2.1.1.107, 4.2.1.75 H Belongs to the precorrin methyltransferase family
NHFKFMEO_03206 1.6e-108 cysC 2.7.1.25 P Catalyzes the synthesis of activated sulfate
NHFKFMEO_03207 1.5e-222 sat 2.7.7.4 P Belongs to the sulfate adenylyltransferase family
NHFKFMEO_03208 1.2e-178 cysP P phosphate transporter
NHFKFMEO_03209 1.7e-141 cysH 1.8.4.10, 1.8.4.8, 2.7.1.25 EH Belongs to the PAPS reductase family. CysH subfamily
NHFKFMEO_03211 3.3e-115 pyrE 2.4.2.10, 4.1.1.23 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NHFKFMEO_03212 8e-126 pyrF 4.1.1.23 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
NHFKFMEO_03213 5.4e-175 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
NHFKFMEO_03214 5e-142 pyrK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )
NHFKFMEO_03215 0.0 carB 6.3.5.5 F Belongs to the CarB family
NHFKFMEO_03216 5e-212 carA 6.3.5.5 F Carbamoyl-phosphate synthetase glutamine chain
NHFKFMEO_03217 1.6e-249 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
NHFKFMEO_03218 3.4e-166 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
NHFKFMEO_03219 5.4e-229 pyrP F Xanthine uracil
NHFKFMEO_03220 2.7e-94 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NHFKFMEO_03221 1.8e-162 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
NHFKFMEO_03222 1.8e-78 lspA 3.4.23.36 MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NHFKFMEO_03223 3.8e-63 dksA T COG1734 DnaK suppressor protein
NHFKFMEO_03224 0.0 ileS 6.1.1.5 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NHFKFMEO_03225 7.5e-67 divIVA D Cell division initiation protein
NHFKFMEO_03226 2e-138 ylmH 5.4.99.23, 5.4.99.24 S conserved protein, contains S4-like domain
NHFKFMEO_03227 1.3e-39 yggT S membrane
NHFKFMEO_03228 1.5e-61 sepF D Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
NHFKFMEO_03229 6.5e-125 ylmE S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NHFKFMEO_03230 2.4e-158 yfiH S Belongs to the multicopper oxidase YfiH RL5 family
NHFKFMEO_03231 2.4e-37 ylmC S sporulation protein
NHFKFMEO_03232 6.8e-253 argE 3.5.1.16 E Acetylornithine deacetylase
NHFKFMEO_03233 1.4e-144 modF 3.6.3.21, 3.6.3.34 P COG1119 ABC-type molybdenum transport system, ATPase component photorepair protein PhrA
NHFKFMEO_03234 3.6e-140 sigG K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NHFKFMEO_03235 1.4e-125 sigE K sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NHFKFMEO_03236 1.2e-171 spoIIGA M aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR
NHFKFMEO_03238 0.0 bpr O COG1404 Subtilisin-like serine proteases
NHFKFMEO_03239 2e-203 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NHFKFMEO_03240 7e-229 ftsA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
NHFKFMEO_03241 6.2e-58 sbp S small basic protein
NHFKFMEO_03242 5.1e-102 ylxX S protein conserved in bacteria
NHFKFMEO_03243 3.1e-103 ylxW S protein conserved in bacteria
NHFKFMEO_03244 2.6e-138 divIB D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
NHFKFMEO_03245 5.3e-167 murB 1.3.1.98 M cell wall formation
NHFKFMEO_03246 4.3e-200 murG 2.4.1.227, 6.3.2.8 GT28 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NHFKFMEO_03247 5.7e-186 spoVE D Belongs to the SEDS family
NHFKFMEO_03248 6.5e-254 murD 6.3.2.9 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NHFKFMEO_03249 3.2e-170 mraY 2.7.8.13 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NHFKFMEO_03250 3.7e-279 murE 6.3.2.10, 6.3.2.13 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NHFKFMEO_03251 0.0 ftsI 3.4.16.4 M stage V sporulation protein D
NHFKFMEO_03252 0.0 ftsI 3.4.16.4 M Penicillin-binding Protein
NHFKFMEO_03253 1.4e-43 ftsL D Essential cell division protein
NHFKFMEO_03254 1.4e-170 rsmH 2.1.1.199 J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
NHFKFMEO_03255 2.9e-78 mraZ K Belongs to the MraZ family
NHFKFMEO_03256 4.6e-307 bshC S Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
NHFKFMEO_03257 3e-167 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NHFKFMEO_03258 4e-89 ylbP K n-acetyltransferase
NHFKFMEO_03259 6.8e-75 ylbO S SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
NHFKFMEO_03260 1.2e-27 rpmF J Belongs to the bacterial ribosomal protein bL32 family
NHFKFMEO_03261 2.3e-90 yceD S metal-binding, possibly nucleic acid-binding protein
NHFKFMEO_03263 4.8e-123 ylbM S Belongs to the UPF0348 family
NHFKFMEO_03264 9.8e-14 yqgA
NHFKFMEO_03265 7.4e-186 ylbL T Belongs to the peptidase S16 family
NHFKFMEO_03266 7.5e-138 ylbK S esterase of the alpha-beta hydrolase superfamily
NHFKFMEO_03267 3.6e-219 ylbJ S Sporulation integral membrane protein YlbJ
NHFKFMEO_03268 3.9e-84 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NHFKFMEO_03269 1.9e-95 rsmD 2.1.1.171 L Methyltransferase
NHFKFMEO_03270 7.5e-39 ylbG S UPF0298 protein
NHFKFMEO_03271 1.8e-75 ylbF S Belongs to the UPF0342 family
NHFKFMEO_03272 6.7e-37 ylbE S YlbE-like protein
NHFKFMEO_03273 2.6e-62 ylbD S Putative coat protein
NHFKFMEO_03274 4.8e-199 ylbC S protein with SCP PR1 domains
NHFKFMEO_03275 2.6e-74 ylbB T COG0517 FOG CBS domain
NHFKFMEO_03276 7e-62 ylbA S YugN-like family
NHFKFMEO_03277 3e-167 ctaG S cytochrome c oxidase
NHFKFMEO_03278 4.2e-53 ctaF 1.10.3.12, 1.9.3.1 C COG3125 Heme copper-type cytochrome quinol oxidase, subunit 4
NHFKFMEO_03279 3.3e-112 cyoC 1.10.3.12, 1.9.3.1 C COG1845 Heme copper-type cytochrome quinol oxidase, subunit 3
NHFKFMEO_03280 0.0 ctaD 1.10.3.12, 1.9.3.1 C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NHFKFMEO_03281 6.2e-191 ctaC 1.9.3.1 C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)
NHFKFMEO_03282 3.2e-164 ctaB 2.5.1.141 O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
NHFKFMEO_03283 3.2e-164 ctaA 2.5.1.141 O Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group
NHFKFMEO_03284 0.0 pyc 6.4.1.1 C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
NHFKFMEO_03285 2.7e-211 ftsW D Belongs to the SEDS family
NHFKFMEO_03286 8.7e-44 ylaN S Belongs to the UPF0358 family
NHFKFMEO_03287 1.6e-171 glsA 3.5.1.2 E Belongs to the glutaminase family
NHFKFMEO_03288 3.9e-84 ylaL S Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NHFKFMEO_03289 8e-249 phoH T ATPase related to phosphate starvation-inducible protein PhoH
NHFKFMEO_03290 4e-89 ylaJ S Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
NHFKFMEO_03291 2.5e-32 ylaI S protein conserved in bacteria
NHFKFMEO_03292 4.2e-47 ylaH S YlaH-like protein
NHFKFMEO_03293 0.0 typA T GTP-binding protein TypA
NHFKFMEO_03294 8.2e-22 S Family of unknown function (DUF5325)
NHFKFMEO_03295 2.6e-37 ylaE
NHFKFMEO_03296 3.5e-11 sigC S Putative zinc-finger
NHFKFMEO_03297 2.1e-26 ylaC K Belongs to the sigma-70 factor family. ECF subfamily
NHFKFMEO_03298 1.4e-53 ylaC K Belongs to the sigma-70 factor family. ECF subfamily
NHFKFMEO_03299 7.8e-42 ylaB
NHFKFMEO_03300 0.0 ylaA
NHFKFMEO_03301 2.2e-293 mpl 3.4.24.28, 3.4.24.29 E Peptidase M4
NHFKFMEO_03302 2.3e-170 Q Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
NHFKFMEO_03303 3.4e-77 ykzC S Acetyltransferase (GNAT) family
NHFKFMEO_03304 2e-149 suhB 3.1.3.25 G Inositol monophosphatase
NHFKFMEO_03305 7.1e-26 ykzI
NHFKFMEO_03306 2.1e-117 yktB S Belongs to the UPF0637 family
NHFKFMEO_03307 2e-42 yktA S Belongs to the UPF0223 family
NHFKFMEO_03308 1e-276 speA 4.1.1.19 E Arginine
NHFKFMEO_03309 1.3e-63 slp CO COG0526, thiol-disulfide isomerase and thioredoxins
NHFKFMEO_03310 2.4e-243 lpdA 1.8.1.4 C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
NHFKFMEO_03311 9.9e-231 pdhC 2.3.1.12 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
NHFKFMEO_03312 4.9e-179 pdhB 1.2.4.1 C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
NHFKFMEO_03313 9.9e-192 pdhA 1.2.4.1, 1.2.4.4 C COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
NHFKFMEO_03314 4.6e-109 recN L Putative cell-wall binding lipoprotein
NHFKFMEO_03316 2.6e-100 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
NHFKFMEO_03317 5.5e-147 ykrA S hydrolases of the HAD superfamily
NHFKFMEO_03318 8.2e-31 ykzG S Belongs to the UPF0356 family
NHFKFMEO_03319 0.0 rnjA S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NHFKFMEO_03320 0.0 ade 3.5.4.2 F Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NHFKFMEO_03321 4e-116 ktrA P COG0569 K transport systems, NAD-binding component
NHFKFMEO_03322 3.2e-155 ykqA P Gamma-glutamyl cyclotransferase, AIG2-like
NHFKFMEO_03323 2.7e-241 kinC 2.7.13.3 T COG0642 Signal transduction histidine kinase
NHFKFMEO_03324 1.5e-43 abrB K of stationary sporulation gene expression
NHFKFMEO_03325 7.7e-183 mreB D Rod-share determining protein MreBH
NHFKFMEO_03326 1.1e-12 S Uncharacterized protein YkpC
NHFKFMEO_03327 5.9e-238 ampS E COG2309 Leucyl aminopeptidase (aminopeptidase T)
NHFKFMEO_03328 1.4e-167 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NHFKFMEO_03329 5.8e-310 ybiT S COG0488 ATPase components of ABC transporters with duplicated ATPase domains
NHFKFMEO_03330 8.1e-39 ykoA
NHFKFMEO_03331 4.8e-105 sipT 3.4.21.89 U Belongs to the peptidase S26 family
NHFKFMEO_03332 0.0 fruA 2.7.1.202 GT COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type)
NHFKFMEO_03333 3.1e-167 fruK 2.7.1.11, 2.7.1.56 G Belongs to the carbohydrate kinase PfkB family
NHFKFMEO_03334 3.1e-136 fruR K Transcriptional regulator
NHFKFMEO_03335 2.1e-208 yknZ V COG0577 ABC-type antimicrobial peptide transport system, permease component
NHFKFMEO_03336 2.5e-124 macB V ABC transporter, ATP-binding protein
NHFKFMEO_03337 1.1e-158 acrA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NHFKFMEO_03338 1e-117 yknW S Yip1 domain
NHFKFMEO_03339 0.0 yknV V COG1132 ABC-type multidrug transport system, ATPase and permease components
NHFKFMEO_03340 0.0 yknU V COG1132 ABC-type multidrug transport system, ATPase and permease components
NHFKFMEO_03341 2.8e-32 moaD 2.8.1.12 H Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NHFKFMEO_03342 3.2e-83 moaE 2.8.1.12 H COG0314 Molybdopterin converting factor, large subunit
NHFKFMEO_03343 1.3e-93 mobB 2.10.1.1, 2.7.7.77 H molybdopterin-guanine dinucleotide biosynthesis protein
NHFKFMEO_03344 8.1e-246 moeA 2.10.1.1 H molybdopterin
NHFKFMEO_03345 6.5e-190 moeB 2.7.7.73, 2.7.7.80 H COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
NHFKFMEO_03346 3.3e-109 mobA 2.7.7.77 H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
NHFKFMEO_03347 4.2e-146 yknT
NHFKFMEO_03348 5.8e-95 rok K Repressor of ComK
NHFKFMEO_03349 7e-80 ykuV CO thiol-disulfide
NHFKFMEO_03350 3.9e-101 ykuU O Alkyl hydroperoxide reductase
NHFKFMEO_03351 8.8e-142 ykuT M Mechanosensitive ion channel
NHFKFMEO_03352 9e-37 ykuS S Belongs to the UPF0180 family
NHFKFMEO_03353 1.2e-213 hipO 3.5.1.47 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
NHFKFMEO_03354 1.1e-74 dapD 2.3.1.117, 2.3.1.89 E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
NHFKFMEO_03355 8.7e-78 fld C Flavodoxin
NHFKFMEO_03356 2.6e-174 ykuO
NHFKFMEO_03357 1.7e-84 fld C Flavodoxin domain
NHFKFMEO_03358 3.5e-168 ccpC K Transcriptional regulator
NHFKFMEO_03359 1.6e-76 ykuL S CBS domain
NHFKFMEO_03360 3.9e-27 ykzF S Antirepressor AbbA
NHFKFMEO_03361 4.4e-94 ykuK S Ribonuclease H-like
NHFKFMEO_03362 3.9e-37 ykuJ S protein conserved in bacteria
NHFKFMEO_03363 5.2e-234 ykuI T Diguanylate phosphodiesterase
NHFKFMEO_03364 2.2e-142 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
NHFKFMEO_03365 9.4e-166 ykuE S Metallophosphoesterase
NHFKFMEO_03366 1.8e-87 ykuD S protein conserved in bacteria
NHFKFMEO_03367 9.9e-236 ykuC EGP Major facilitator Superfamily
NHFKFMEO_03368 1.7e-84 ykyB S YkyB-like protein
NHFKFMEO_03369 6.2e-168 cheV 2.7.13.3 T Chemotaxis protein CheV
NHFKFMEO_03370 2.2e-15
NHFKFMEO_03371 8.8e-223 patA 2.6.1.1 E Aminotransferase
NHFKFMEO_03372 0.0 pilS 2.7.13.3 T Histidine kinase
NHFKFMEO_03373 0.0 mrdA 3.4.16.4 M Penicillin-binding Protein
NHFKFMEO_03374 8e-124 ykwD J protein with SCP PR1 domains
NHFKFMEO_03375 8.6e-159 glxR 1.1.1.31, 1.1.1.60 I COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases
NHFKFMEO_03376 1.4e-257 mcpC NT chemotaxis protein
NHFKFMEO_03377 1.7e-130 ykwB 2.3.1.1 K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
NHFKFMEO_03378 2.6e-202 splB 4.1.99.14 L Spore photoproduct lyase
NHFKFMEO_03379 7.2e-39 splA S Transcriptional regulator
NHFKFMEO_03380 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NHFKFMEO_03381 2.1e-39 ptsH G phosphocarrier protein HPr
NHFKFMEO_03382 0.0 ptsG 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
NHFKFMEO_03383 1.7e-127 glcT K antiterminator
NHFKFMEO_03385 2.4e-178 ykvZ 5.1.1.1 K Transcriptional regulator
NHFKFMEO_03386 4.3e-208 pepQ 3.4.13.9 E COG0006 Xaa-Pro aminopeptidase
NHFKFMEO_03387 1e-09
NHFKFMEO_03388 0.0 cadA 3.6.3.3, 3.6.3.5 P COG2217 Cation transport ATPase
NHFKFMEO_03389 1.6e-88 stoA CO thiol-disulfide
NHFKFMEO_03390 2.9e-238 ykvU S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
NHFKFMEO_03391 2.8e-90 ykvT 3.5.1.28 M Cell Wall Hydrolase
NHFKFMEO_03392 2.8e-28
NHFKFMEO_03393 6e-25 ykvS S protein conserved in bacteria
NHFKFMEO_03394 6.9e-40 ykvR S Protein of unknown function (DUF3219)
NHFKFMEO_03395 7.7e-144 G Glycosyl hydrolases family 18
NHFKFMEO_03396 3.5e-35 3.5.1.104 M LysM domain
NHFKFMEO_03397 2.4e-214 ykvP 3.5.1.28 M Glycosyl transferases group 1
NHFKFMEO_03398 8.2e-134 IQ Enoyl-(Acyl carrier protein) reductase
NHFKFMEO_03399 3.4e-61 ykvN K Transcriptional regulator
NHFKFMEO_03400 2e-96 queF 1.7.1.13 S Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NHFKFMEO_03401 1.3e-139 queE 1.97.1.4, 4.3.99.3 H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
NHFKFMEO_03402 2.8e-81 queD 4.1.2.50, 4.2.3.12 H synthase
NHFKFMEO_03403 7.3e-126 queC 6.3.4.20 F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NHFKFMEO_03404 1.8e-179 ykvI S membrane
NHFKFMEO_03405 0.0 clpE O Belongs to the ClpA ClpB family
NHFKFMEO_03406 1e-137 motA N flagellar motor
NHFKFMEO_03407 2.5e-125 motB N Flagellar motor protein
NHFKFMEO_03408 1.3e-75 ykvE K transcriptional
NHFKFMEO_03409 1.4e-273 kinD 2.7.13.3 T COG0642 Signal transduction histidine kinase
NHFKFMEO_03410 1.8e-64 eag
NHFKFMEO_03411 6.4e-09 S Spo0E like sporulation regulatory protein
NHFKFMEO_03412 2.9e-51 XK27_09985 S Protein of unknown function (DUF1232)
NHFKFMEO_03413 8.4e-96 mtnD 1.13.11.53, 1.13.11.54 S Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
NHFKFMEO_03414 1.6e-114 mtnB 3.1.3.87, 4.1.2.17, 4.2.1.109, 5.1.3.4 E Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P)
NHFKFMEO_03415 1.1e-135 mtnX 3.1.3.87, 4.2.1.109 E Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
NHFKFMEO_03416 3.4e-230 mtnW 5.3.2.5 G Catalyzes the enolization of 2,3-diketo-5- methylthiopentyl-1-phosphate (DK-MTP-1-P) into 2-hydroxy-3-keto-5- methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P)
NHFKFMEO_03417 1.1e-228 mtnE 2.6.1.83 E Aminotransferase
NHFKFMEO_03418 1.5e-149 mtnU 3.5.1.3 S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
NHFKFMEO_03419 2.9e-76 ctsR K Belongs to the CtsR family
NHFKFMEO_03420 1.6e-47 mcsA 2.7.14.1 S protein with conserved CXXC pairs
NHFKFMEO_03421 6.1e-202 mcsB 2.7.14.1, 2.7.3.2, 2.7.3.3 E Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity
NHFKFMEO_03422 0.0 clpC O Belongs to the ClpA ClpB family
NHFKFMEO_03423 9.6e-256 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NHFKFMEO_03424 1.3e-196 disA 2.7.7.85 L Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
NHFKFMEO_03425 2.7e-197 yacL S COG4956 Integral membrane protein (PIN domain superfamily)
NHFKFMEO_03426 3.8e-125 ispD 2.7.7.60, 4.6.1.12 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)
NHFKFMEO_03427 1.2e-85 ispF 2.1.1.228, 2.7.7.60, 4.6.1.12 I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)
NHFKFMEO_03428 2.5e-280 gltX 6.1.1.17, 6.1.1.24 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NHFKFMEO_03429 7.2e-118 cysE 2.3.1.30 E Serine acetyltransferase
NHFKFMEO_03430 3.2e-272 cysS 6.1.1.16, 6.3.1.13 J Belongs to the class-I aminoacyl-tRNA synthetase family
NHFKFMEO_03431 3e-72 mrnC J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
NHFKFMEO_03432 1.3e-134 trmH 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NHFKFMEO_03433 1.2e-88 yacP S RNA-binding protein containing a PIN domain
NHFKFMEO_03434 4.4e-115 sigH K Belongs to the sigma-70 factor family
NHFKFMEO_03435 1e-21 secE U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
NHFKFMEO_03436 8.9e-96 nusG K Participates in transcription elongation, termination and antitermination
NHFKFMEO_03437 2.8e-70 rplK J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NHFKFMEO_03438 1.1e-124 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
NHFKFMEO_03439 5.1e-79 rplJ J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NHFKFMEO_03440 1.3e-42 rplL J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
NHFKFMEO_03441 8.2e-108 rsmC 2.1.1.172 J Methyltransferase
NHFKFMEO_03442 0.0 rpoB 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NHFKFMEO_03443 0.0 rpoC 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NHFKFMEO_03444 8e-33 ybxF J Belongs to the eukaryotic ribosomal protein eL8 family
NHFKFMEO_03445 8.5e-72 rpsL J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NHFKFMEO_03446 6e-82 rpsG J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
NHFKFMEO_03447 0.0 fusA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NHFKFMEO_03448 2.5e-225 tuf J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NHFKFMEO_03449 1.3e-179 ybaC 3.4.11.5 S Alpha/beta hydrolase family
NHFKFMEO_03450 7.5e-49 rpsJ J Involved in the binding of tRNA to the ribosomes
NHFKFMEO_03451 6.3e-111 rplC J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NHFKFMEO_03452 3e-105 rplD J Forms part of the polypeptide exit tunnel
NHFKFMEO_03453 1.2e-43 rplW J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
NHFKFMEO_03454 1.5e-155 rplB J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NHFKFMEO_03455 3.7e-47 rpsS J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NHFKFMEO_03456 4.3e-53 rplV J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NHFKFMEO_03457 8e-117 rpsC J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NHFKFMEO_03458 1.3e-75 rplP J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NHFKFMEO_03459 1.7e-25 rpmC J Belongs to the universal ribosomal protein uL29 family
NHFKFMEO_03460 3.5e-39 rpsQ J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NHFKFMEO_03461 3.9e-60 rplN J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NHFKFMEO_03462 6.2e-51 rplX J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NHFKFMEO_03463 4.6e-94 rplE J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NHFKFMEO_03464 3.4e-28 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NHFKFMEO_03465 3.9e-66 rpsH J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NHFKFMEO_03466 1.3e-93 rplF J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NHFKFMEO_03467 4e-57 rplR J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NHFKFMEO_03468 3.1e-84 rpsE J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NHFKFMEO_03469 1.9e-23 rpmD J Ribosomal protein L30
NHFKFMEO_03470 1.8e-72 rplO J binds to the 23S rRNA
NHFKFMEO_03471 4.2e-234 secY U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
NHFKFMEO_03472 1.3e-122 adk 2.7.4.3 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
NHFKFMEO_03473 3.7e-142 map 3.4.11.18 E Methionine aminopeptidase
NHFKFMEO_03474 1.1e-33 infA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NHFKFMEO_03475 4.2e-13 rpmJ J Belongs to the bacterial ribosomal protein bL36 family
NHFKFMEO_03476 3.1e-57 rpsM J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NHFKFMEO_03477 2.1e-64 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NHFKFMEO_03478 3.1e-170 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NHFKFMEO_03479 3.6e-58 rplQ J Ribosomal protein L17
NHFKFMEO_03480 2.5e-155 cbiO P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NHFKFMEO_03481 1.7e-154 ecfA2 3.6.3.55 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NHFKFMEO_03482 1e-118 ecfT P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NHFKFMEO_03483 8.2e-142 truA 5.4.99.12 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
NHFKFMEO_03484 6.4e-78 rplM J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NHFKFMEO_03485 4.7e-64 rpsI J Belongs to the universal ribosomal protein uS9 family
NHFKFMEO_03486 9e-144 ybaJ Q Methyltransferase domain
NHFKFMEO_03487 9.7e-66 ybaK S Protein of unknown function (DUF2521)
NHFKFMEO_03488 2.5e-132 cwlD 3.5.1.28 M n-acetylmuramoyl-L-alanine amidase
NHFKFMEO_03489 1.4e-198 mrp D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP
NHFKFMEO_03490 1.2e-84 gerD
NHFKFMEO_03491 1.3e-102 kbaA 2.7.8.43 S Involved in the activation of the KinB signaling pathway of sporulation
NHFKFMEO_03492 7.9e-140 pdaB 3.5.1.104 G Polysaccharide deacetylase
NHFKFMEO_03493 1.2e-77
NHFKFMEO_03494 7.5e-103 phzA Q Isochorismatase family
NHFKFMEO_03495 7e-240 ywoD EGP Major facilitator superfamily
NHFKFMEO_03496 3e-281 ybbW FH COG1953 Cytosine uracil thiamine allantoin permeases
NHFKFMEO_03497 2.8e-231 ywoF P Right handed beta helix region
NHFKFMEO_03498 3.9e-210 ywoG EGP Major facilitator Superfamily
NHFKFMEO_03499 2.1e-70 ywoH K COG1846 Transcriptional regulators
NHFKFMEO_03500 3e-44 spoIIID K Stage III sporulation protein D
NHFKFMEO_03501 3.5e-180 mbl D Rod shape-determining protein
NHFKFMEO_03502 9.9e-125 flhO N flagellar basal body
NHFKFMEO_03503 3.7e-140 flhP N flagellar basal body
NHFKFMEO_03504 8.8e-198 S aspartate phosphatase
NHFKFMEO_03505 4.6e-82 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
NHFKFMEO_03506 3.9e-50 mscL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
NHFKFMEO_03507 7e-153 ywpD T Histidine kinase
NHFKFMEO_03508 1.2e-49 srtA 3.4.22.70 M Sortase family
NHFKFMEO_03509 1.1e-66 ywpF S YwpF-like protein
NHFKFMEO_03510 3.8e-66 ywpG
NHFKFMEO_03511 3.7e-57 ssbB L Single-stranded DNA-binding protein
NHFKFMEO_03512 8.8e-139 glcR K COG1349 Transcriptional regulators of sugar metabolism
NHFKFMEO_03513 1.3e-154 ywpJ 3.1.3.104 S hydrolases of the HAD superfamily
NHFKFMEO_03514 0.0 ywqA L COG0553 Superfamily II DNA RNA helicases, SNF2 family
NHFKFMEO_03515 1.4e-308 ywqB S SWIM zinc finger
NHFKFMEO_03516 1.2e-17
NHFKFMEO_03517 3.5e-116 ywqC M biosynthesis protein
NHFKFMEO_03518 2.2e-117 ywqD 2.7.10.1 D COG0489 ATPases involved in chromosome partitioning
NHFKFMEO_03519 3e-139 ywqE 3.1.3.48 GM COG4464 Capsular polysaccharide biosynthesis protein
NHFKFMEO_03520 5.2e-248 ugd 1.1.1.22 M Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NHFKFMEO_03521 5.4e-152 ywqG S Domain of unknown function (DUF1963)
NHFKFMEO_03522 1.7e-19 S Domain of unknown function (DUF5082)
NHFKFMEO_03523 3.1e-38 ywqI S Family of unknown function (DUF5344)
NHFKFMEO_03524 4.8e-239 ywqJ S Pre-toxin TG
NHFKFMEO_03525 2.5e-75
NHFKFMEO_03526 5.6e-51
NHFKFMEO_03528 2.2e-98
NHFKFMEO_03529 3.1e-122 nfi 3.1.21.7 L DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA
NHFKFMEO_03530 1.4e-161 K Transcriptional regulator
NHFKFMEO_03531 1.1e-100 ywqN S NAD(P)H-dependent
NHFKFMEO_03533 9.9e-89 ywrA P COG2059 Chromate transport protein ChrA
NHFKFMEO_03534 1.2e-103 ywrB P Chromate transporter
NHFKFMEO_03535 8e-82 ywrC K Transcriptional regulator
NHFKFMEO_03536 1.4e-308 ggt 2.3.2.2, 3.4.19.13 E gamma-glutamyltransferase
NHFKFMEO_03537 1.4e-53 S Domain of unknown function (DUF4181)
NHFKFMEO_03538 8.1e-111 ywrF S COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NHFKFMEO_03539 3.7e-12
NHFKFMEO_03540 3.5e-210 cotH M Spore Coat
NHFKFMEO_03541 7.1e-131 cotB
NHFKFMEO_03542 2.7e-123 ywrJ
NHFKFMEO_03543 7.2e-220 ywrK P Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NHFKFMEO_03544 1.1e-169 alsR K LysR substrate binding domain
NHFKFMEO_03545 0.0 alsS 2.2.1.6 EH Belongs to the TPP enzyme family
NHFKFMEO_03546 2.8e-145 budA 4.1.1.5 H Alpha-acetolactate decarboxylase
NHFKFMEO_03547 1.5e-97 ywrO S NADPH-quinone reductase (modulator of drug activity B)
NHFKFMEO_03548 8e-48 ywsA S Protein of unknown function (DUF3892)
NHFKFMEO_03549 8.7e-93 batE T Sh3 type 3 domain protein
NHFKFMEO_03550 1.1e-159 rbsB G COG1879 ABC-type sugar transport system, periplasmic component
NHFKFMEO_03551 2.1e-153 rbsC G Belongs to the binding-protein-dependent transport system permease family
NHFKFMEO_03552 6.2e-274 rbsA 3.6.3.17 G Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system
NHFKFMEO_03553 1.4e-63 rbsD 5.4.99.62 G Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose
NHFKFMEO_03554 2.1e-160 rbsK 2.7.1.15, 2.7.1.4 H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NHFKFMEO_03555 9.3e-178 rbsR K transcriptional
NHFKFMEO_03556 6.1e-224 murD 6.3.2.9 M COG0769 UDP-N-acetylmuramyl tripeptide synthase
NHFKFMEO_03557 8.6e-70 pgsC S biosynthesis protein
NHFKFMEO_03558 8.2e-218 capA M enzyme of poly-gamma-glutamate biosynthesis (capsule formation)
NHFKFMEO_03559 1.4e-20 ywtC
NHFKFMEO_03560 2e-239 pgdS CBM50 M COG0791 Cell wall-associated hydrolases (invasion-associated proteins)
NHFKFMEO_03561 2.9e-159 ywtE 3.1.3.104 S hydrolases of the HAD superfamily
NHFKFMEO_03562 4.2e-170 ywtF K Transcriptional regulator
NHFKFMEO_03563 1.3e-246 ywtG EGP Major facilitator Superfamily
NHFKFMEO_03564 9.9e-216 gerAC S Spore germination protein
NHFKFMEO_03565 4.9e-199 gerBB E Spore germination protein
NHFKFMEO_03566 4.6e-266 gerBA EG Spore germination protein
NHFKFMEO_03567 7.9e-190 pmi 5.3.1.8 G mannose-6-phosphate isomerase
NHFKFMEO_03568 3e-215 atl 3.2.1.96, 3.5.1.28 GH73 G Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
NHFKFMEO_03569 3.5e-260
NHFKFMEO_03570 1.5e-214 tagB 2.7.8.14, 2.7.8.44, 2.7.8.47 M glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NHFKFMEO_03571 4.5e-143 tagA 2.4.1.187 GT26 M Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid
NHFKFMEO_03572 5.7e-70 tagD 2.7.7.15, 2.7.7.39 IM Cytidylyltransferase
NHFKFMEO_03573 0.0 tagE 2.4.1.52 GT4 M Glycosyl transferase 1 domain A
NHFKFMEO_03574 0.0 tagF 2.7.8.12 M glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NHFKFMEO_03575 4.1e-150 tagG GM Transport permease protein
NHFKFMEO_03576 9.2e-268 tagH 3.6.3.38, 3.6.3.40 GM Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system
NHFKFMEO_03577 1.9e-36 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
NHFKFMEO_03578 1.9e-54 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
NHFKFMEO_03579 1.5e-11 2.7.8.12 M CDPglycerol
NHFKFMEO_03580 3e-39 tagF 2.7.8.12 M glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NHFKFMEO_03581 7.5e-93 ggaA M Glycosyltransferase like family 2
NHFKFMEO_03582 8.2e-208 ggaB GT2 M CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
NHFKFMEO_03583 6.5e-57
NHFKFMEO_03584 2.6e-163 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
NHFKFMEO_03585 5.3e-217 mnaA 5.1.3.14 M Belongs to the UDP-N-acetylglucosamine 2-epimerase family
NHFKFMEO_03586 4e-162 lytR K May catalyze the final step in cell wall teichoic acid biosynthesis, the transfer of the anionic cell wall polymers (APs) from their lipid-linked precursor to the cell wall peptidoglycan (PG)
NHFKFMEO_03587 6e-38
NHFKFMEO_03588 0.0 lytB 3.5.1.28 D Stage II sporulation protein
NHFKFMEO_03589 7.3e-267 lytC 3.5.1.28 M n-acetylmuramoyl-L-alanine amidase
NHFKFMEO_03590 4.6e-112 tuaA M COG2148 Sugar transferases involved in lipopolysaccharide synthesis
NHFKFMEO_03591 4.4e-248 wzxC S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
NHFKFMEO_03592 5.8e-219 tuaC 2.4.1.21, 3.2.1.1 GH13,GT4,GT5 GM Teichuronic acid
NHFKFMEO_03593 7.6e-258 tuaD 1.1.1.22 M Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NHFKFMEO_03594 1.6e-261 tuaE M Teichuronic acid biosynthesis protein
NHFKFMEO_03595 1.9e-113 tuaF M protein involved in exopolysaccharide biosynthesis
NHFKFMEO_03596 1.4e-144 tuaG GT2 M Glycosyltransferase like family 2
NHFKFMEO_03597 8.6e-234 tuaH M Teichuronic acid biosynthesis glycosyltransferase tuaH
NHFKFMEO_03598 2.6e-181 tagO 2.7.8.33, 2.7.8.35 M COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase UDP-N-acetylglucosamine-1-phosphate transferase
NHFKFMEO_03599 6e-163 yvhJ K Transcriptional regulator
NHFKFMEO_03600 2e-120 yvyE 3.4.13.9 S Domain of unknown function (DUF1949)
NHFKFMEO_03601 5.1e-183 degS 2.7.13.3 T Member of the two-component regulatory system DegS DegU, which plays an important role in the transition growth phase
NHFKFMEO_03602 2e-126 degU KT COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
NHFKFMEO_03603 1.1e-153 degV S protein conserved in bacteria
NHFKFMEO_03604 5.6e-269 comFA L COG4098 Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
NHFKFMEO_03605 5.7e-46 comFB S Late competence development protein ComFB
NHFKFMEO_03606 2.7e-129 comFC S Phosphoribosyl transferase domain
NHFKFMEO_03607 7e-74 yvyF S flagellar protein
NHFKFMEO_03608 8e-39 flgM KNU Negative regulator of flagellin synthesis
NHFKFMEO_03609 2.4e-78 flgN NOU FlgN protein
NHFKFMEO_03610 5.6e-262 flgK N flagellar hook-associated protein
NHFKFMEO_03611 7.8e-155 flgL N Belongs to the bacterial flagellin family
NHFKFMEO_03612 1.3e-49 yviE
NHFKFMEO_03613 2.7e-73 fliW S Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
NHFKFMEO_03614 5.7e-30 csrA T Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
NHFKFMEO_03615 1.4e-108 fliC N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NHFKFMEO_03616 1.2e-55 flaG N flagellar protein FlaG
NHFKFMEO_03617 2e-256 fliD N morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
NHFKFMEO_03618 6.5e-69 fliS N flagellar protein FliS
NHFKFMEO_03619 2.5e-08 fliT S bacterial-type flagellum organization
NHFKFMEO_03620 1.1e-49
NHFKFMEO_03621 2.2e-102 hpf J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NHFKFMEO_03622 0.0 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
NHFKFMEO_03623 6.1e-185 prfB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NHFKFMEO_03624 5.5e-142 yvjA S Uncharacterized protein conserved in bacteria (DUF2179)
NHFKFMEO_03625 5.3e-56 cccB C COG2010 Cytochrome c, mono- and diheme variants
NHFKFMEO_03626 1.6e-123 ftsE D cell division ATP-binding protein FtsE
NHFKFMEO_03627 1.6e-155 ftsX D Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation
NHFKFMEO_03628 2.6e-269 ctpB 3.4.21.102 M Belongs to the peptidase S41A family
NHFKFMEO_03629 5.3e-56 swrA S Swarming motility protein
NHFKFMEO_03630 1.9e-220 minJ O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NHFKFMEO_03631 1.8e-224 yvkA EGP Major facilitator Superfamily
NHFKFMEO_03632 1e-99 yvkB K Transcriptional regulator
NHFKFMEO_03633 0.0 yvkC 2.7.9.2 GT Phosphotransferase
NHFKFMEO_03634 1.2e-30 csbA S protein conserved in bacteria
NHFKFMEO_03635 0.0 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
NHFKFMEO_03636 0.0 uvrA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
NHFKFMEO_03637 9.2e-78 fliC N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NHFKFMEO_03638 7.4e-33 yvkN
NHFKFMEO_03639 8.8e-48 yvlA
NHFKFMEO_03640 9.8e-168 yvlB S Putative adhesin
NHFKFMEO_03641 2.6e-26 pspB KT PspC domain
NHFKFMEO_03642 1.2e-50 yvlD S Membrane
NHFKFMEO_03643 0.0 yvnB 3.1.4.53 Q Calcineurin-like phosphoesterase
NHFKFMEO_03644 1.8e-133 yvoA K transcriptional
NHFKFMEO_03645 4.3e-127 nagB 3.1.1.31, 3.5.99.6 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
NHFKFMEO_03646 2.4e-220 nagA 3.5.1.25 G Belongs to the metallo-dependent hydrolases superfamily. NagA family
NHFKFMEO_03647 1.7e-168 hprK F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
NHFKFMEO_03648 1.4e-147 lgt 2.1.1.199 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NHFKFMEO_03649 3.3e-164 yvoD P COG0370 Fe2 transport system protein B
NHFKFMEO_03650 6.5e-119 ppaX 3.1.3.18, 3.6.1.1 S Hydrolyzes pyrophosphate formed during P-Ser-HPr dephosphorylation by HPrK P. Might play a role in controlling the intracellular pyrophosphate pool
NHFKFMEO_03651 3e-82 yvoF S COG0110 Acetyltransferase (isoleucine patch superfamily)
NHFKFMEO_03652 5.5e-121 hrpW 4.2.2.10, 4.2.2.2 G Pectate lyase
NHFKFMEO_03653 4.5e-140 yvpB NU protein conserved in bacteria
NHFKFMEO_03654 4.8e-221 hisZ 2.4.2.17, 6.1.1.21 E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
NHFKFMEO_03655 1.5e-115 hisG 2.4.2.17 E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
NHFKFMEO_03656 5.8e-228 hisD 1.1.1.23, 1.1.1.308 E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NHFKFMEO_03657 2.1e-108 hisB 1.1.1.23, 2.6.1.9, 3.1.3.15, 4.2.1.19 E imidazoleglycerol-phosphate dehydratase
NHFKFMEO_03658 4.3e-115 hisH E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NHFKFMEO_03659 1.9e-130 hisA 5.3.1.16 E 1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NHFKFMEO_03660 3.1e-136 hisF E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
NHFKFMEO_03661 1.1e-110 hisE 3.5.4.19, 3.6.1.31, 5.3.1.16 E belongs to the PRA-CH family
NHFKFMEO_03662 2.1e-70
NHFKFMEO_03663 8.5e-252
NHFKFMEO_03665 0.0 msbA2 3.6.3.44 V ABC transporter
NHFKFMEO_03666 1.2e-277 S COG0457 FOG TPR repeat
NHFKFMEO_03667 7.3e-26 L COG3666 Transposase and inactivated derivatives
NHFKFMEO_03668 9.4e-16 L COG3666 Transposase and inactivated derivatives
NHFKFMEO_03669 1.1e-19 L COG3666 Transposase and inactivated derivatives
NHFKFMEO_03670 1e-59 L COG3666 Transposase and inactivated derivatives
NHFKFMEO_03672 1.6e-53 S Protein of unknown function (DUF3238)
NHFKFMEO_03673 5.4e-44 L Molecular Function DNA binding, Biological Process DNA recombination
NHFKFMEO_03674 4e-48 L COG2963 Transposase and inactivated derivatives
NHFKFMEO_03675 6.2e-90 usp CBM50 M protein conserved in bacteria
NHFKFMEO_03676 2.5e-175 trxB 1.8.1.9 C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
NHFKFMEO_03677 1.8e-89 yvcI 3.6.1.55 F COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
NHFKFMEO_03678 5.7e-166 rapZ S Displays ATPase and GTPase activities
NHFKFMEO_03679 7.3e-178 ybhK S Required for morphogenesis under gluconeogenic growth conditions
NHFKFMEO_03680 1.4e-170 whiA K May be required for sporulation
NHFKFMEO_03681 1.6e-36 crh G Phosphocarrier protein Chr
NHFKFMEO_03682 4.3e-138 nhoA 2.3.1.118 Q Belongs to the arylamine N-acetyltransferase family
NHFKFMEO_03683 1.8e-33
NHFKFMEO_03684 1.9e-132 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
NHFKFMEO_03685 1.7e-196 yvcQ 2.7.13.3 T His Kinase A (phosphoacceptor) domain
NHFKFMEO_03686 5.6e-141 yvcR V ABC transporter, ATP-binding protein
NHFKFMEO_03687 0.0 yxdM V ABC transporter (permease)
NHFKFMEO_03688 3.3e-183 ghrB 1.1.1.215, 1.1.1.26, 1.1.1.43, 1.1.1.79, 1.1.1.81 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NHFKFMEO_03689 5.7e-106 ytiB 4.2.1.1 P Reversible hydration of carbon dioxide
NHFKFMEO_03690 2.1e-288 sulP P COG0659 Sulfate permease and related transporters (MFS superfamily)
NHFKFMEO_03691 6.8e-53 yvdC S MazG nucleotide pyrophosphohydrolase domain
NHFKFMEO_03692 3.3e-106 yvdD 3.2.2.10 S Belongs to the LOG family
NHFKFMEO_03693 8.8e-173 yvdE K Transcriptional regulator
NHFKFMEO_03694 0.0 nplT 3.2.1.133, 3.2.1.135, 3.2.1.54 GH13 G Alpha amylase, N-terminal ig-like domain
NHFKFMEO_03695 2.6e-233 mdxE G COG2182 Maltose-binding periplasmic proteins domains
NHFKFMEO_03696 1e-243 malC P COG1175 ABC-type sugar transport systems, permease components
NHFKFMEO_03697 3.9e-148 malD P transport
NHFKFMEO_03698 7.7e-155 malA S Protein of unknown function (DUF1189)
NHFKFMEO_03699 0.0 yvdK 2.4.1.8 GH65 G Glycoside hydrolase, family 65
NHFKFMEO_03700 0.0 malL 3.2.1.10 GH13 G COG0366 Glycosidases
NHFKFMEO_03701 6.1e-120 pgmB 2.4.1.64, 3.1.3.12, 3.2.1.28, 5.4.2.6 GH37,GH65 S Haloacid dehalogenase-like hydrolase
NHFKFMEO_03702 1.2e-103 clpP 3.4.21.92 OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
NHFKFMEO_03704 3.3e-183 S Patatin-like phospholipase
NHFKFMEO_03705 8.4e-270 ygaK C COG0277 FAD FMN-containing dehydrogenases
NHFKFMEO_03706 1.4e-92 yvdQ S Protein of unknown function (DUF3231)
NHFKFMEO_03707 4.1e-50 sugE P Small Multidrug Resistance protein
NHFKFMEO_03708 6.7e-51 ykkC P Small Multidrug Resistance protein
NHFKFMEO_03709 2.6e-106 yvdT K Transcriptional regulator
NHFKFMEO_03710 1.8e-295 yveA E amino acid
NHFKFMEO_03711 0.0 levB 3.2.1.26, 3.2.1.64, 3.2.1.65, 3.2.1.80 GH32 G Belongs to the glycosyl hydrolase 32 family
NHFKFMEO_03712 1.2e-274 sacB 2.4.1.10 GH68 M levansucrase activity
NHFKFMEO_03713 1.1e-261 pbpE V Beta-lactamase
NHFKFMEO_03714 5.4e-124 racX 5.1.1.13 M Belongs to the aspartate glutamate racemases family
NHFKFMEO_03715 8.8e-34 MA20_18690 S Protein of unknown function (DUF3237)
NHFKFMEO_03716 1.7e-92 padC Q Phenolic acid decarboxylase
NHFKFMEO_03718 1.2e-282 pnbA CE10 I Belongs to the type-B carboxylesterase lipase family
NHFKFMEO_03719 6.3e-76 slr K transcriptional
NHFKFMEO_03720 5.2e-122 ywqC M biosynthesis protein
NHFKFMEO_03721 1e-114 epsB 2.7.10.2 D COG0489 ATPases involved in chromosome partitioning
NHFKFMEO_03722 0.0 pglF 4.2.1.115, 4.2.1.135, 4.2.1.46 GM Polysaccharide biosynthesis protein
NHFKFMEO_03723 2.7e-221 epsD GT4 M Glycosyl transferase 4-like
NHFKFMEO_03724 4.1e-158 epsE GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
NHFKFMEO_03725 3.3e-214 epsF GT4 M Glycosyl transferases group 1
NHFKFMEO_03726 3.1e-206 epsG S EpsG family
NHFKFMEO_03727 2e-194 epsH GT2 S Glycosyltransferase like family 2
NHFKFMEO_03728 1.2e-202 epsI GM pyruvyl transferase
NHFKFMEO_03729 2.7e-191 epsJ GT2 S COG0463 Glycosyltransferases involved in cell wall biogenesis
NHFKFMEO_03730 1.4e-257 pglK S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
NHFKFMEO_03731 2.4e-107 epsL M COG2148 Sugar transferases involved in lipopolysaccharide synthesis
NHFKFMEO_03732 1.2e-56 epsM GM COG0110 Acetyltransferase (isoleucine patch superfamily)
NHFKFMEO_03733 1.2e-219 epsN 2.6.1.102 E Belongs to the DegT DnrJ EryC1 family
NHFKFMEO_03734 7.8e-185 yvfF GM Exopolysaccharide biosynthesis protein
NHFKFMEO_03735 1e-31 yvfG S YvfG protein
NHFKFMEO_03736 6.7e-240 rpoN K COG1508 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog
NHFKFMEO_03737 1.8e-306 yvfH C L-lactate permease
NHFKFMEO_03738 1e-112 yvfI K COG2186 Transcriptional regulators
NHFKFMEO_03739 1.8e-184 lacR K Transcriptional regulator
NHFKFMEO_03740 4.4e-228 cycB G COG2182 Maltose-binding periplasmic proteins domains
NHFKFMEO_03741 2.9e-232 malC P COG1175 ABC-type sugar transport systems, permease components
NHFKFMEO_03742 7.2e-150 ganQ P transport
NHFKFMEO_03743 0.0 lacA 3.2.1.23 G beta-galactosidase
NHFKFMEO_03744 2.3e-248 galA 3.2.1.89 G arabinogalactan
NHFKFMEO_03745 3.2e-196 rsbU 3.1.3.3 T response regulator
NHFKFMEO_03746 6.4e-156 rsbQ S Alpha/beta hydrolase family
NHFKFMEO_03747 1.7e-157 yvfR V COG1131 ABC-type multidrug transport system, ATPase component
NHFKFMEO_03748 6.9e-133 yvfS V COG0842 ABC-type multidrug transport system, permease component
NHFKFMEO_03749 1.6e-194 desK 2.7.13.3 T Histidine kinase
NHFKFMEO_03750 1e-105 desR T COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
NHFKFMEO_03751 1e-136 lutA C Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source
NHFKFMEO_03752 2.7e-274 lutB C Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source. Has probably a role as an electron transporter during oxidation of L-lactate
NHFKFMEO_03753 6.7e-133 lutC S Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source
NHFKFMEO_03754 1.3e-193 yvbX S Glycosyl hydrolase
NHFKFMEO_03755 2.8e-241 yvbW E COG1113 Gamma-aminobutyrate permease and related permeases
NHFKFMEO_03756 7.2e-156 yvbV EG EamA-like transporter family
NHFKFMEO_03757 5.1e-159 yvbU K Transcriptional regulator
NHFKFMEO_03758 1.7e-190 yvbT C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NHFKFMEO_03759 2.1e-202 araR K transcriptional
NHFKFMEO_03760 1.6e-252 araE EGP Major facilitator Superfamily
NHFKFMEO_03761 9.1e-184 cggR K COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain
NHFKFMEO_03762 6.2e-185 gapA 1.2.1.12 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
NHFKFMEO_03763 1e-218 pgk 2.7.2.3, 5.3.1.1 F Belongs to the phosphoglycerate kinase family
NHFKFMEO_03764 4.3e-138 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
NHFKFMEO_03765 3.7e-298 gpmI 5.4.2.12 G Catalyzes the interconversion of 2-phosphoglycerate and
NHFKFMEO_03766 8.4e-243 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
NHFKFMEO_03767 3.1e-75 yvbK 3.1.3.25 K acetyltransferase
NHFKFMEO_03768 0.0 tcaA S response to antibiotic
NHFKFMEO_03769 1.3e-120 exoY M Membrane
NHFKFMEO_03770 8.6e-113 yvbH S YvbH-like oligomerisation region
NHFKFMEO_03771 2.7e-101 yvbG U UPF0056 membrane protein
NHFKFMEO_03772 3.5e-97 yvbF K Belongs to the GbsR family
NHFKFMEO_03773 8.8e-212 opuCA 3.6.3.32 E COG1125 ABC-type proline glycine betaine transport systems, ATPase components
NHFKFMEO_03774 4.5e-112 opuCB P COG1174 ABC-type proline glycine betaine transport systems, permease component
NHFKFMEO_03775 9.4e-172 opuCC M COG1732 Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
NHFKFMEO_03776 1.9e-105 opuCD P COG1174 ABC-type proline glycine betaine transport systems, permease component
NHFKFMEO_03777 3.3e-60 yvbF K Belongs to the GbsR family
NHFKFMEO_03778 2.8e-210 opuCA 3.6.3.32 E COG1125 ABC-type proline glycine betaine transport systems, ATPase components
NHFKFMEO_03779 5.6e-110 opuCB P COG1174 ABC-type proline glycine betaine transport systems, permease component
NHFKFMEO_03780 8e-171 opuCC M COG1732 Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
NHFKFMEO_03781 8.1e-112 opuCD P COG1174 ABC-type proline glycine betaine transport systems, permease component
NHFKFMEO_03782 1.1e-213 NT chemotaxis protein
NHFKFMEO_03783 2.2e-54 yodB K transcriptional
NHFKFMEO_03784 5.2e-69 yvaO K Cro/C1-type HTH DNA-binding domain
NHFKFMEO_03785 9.9e-68 K transcriptional
NHFKFMEO_03786 7.5e-36 yvzC K Transcriptional
NHFKFMEO_03787 2.2e-150 yvaM S Serine aminopeptidase, S33
NHFKFMEO_03788 2.4e-23 secG U Preprotein translocase subunit SecG
NHFKFMEO_03789 5.6e-143 est 3.1.1.1 S Carboxylesterase
NHFKFMEO_03790 0.0 rnr K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
NHFKFMEO_03791 1.6e-82 smpB O Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NHFKFMEO_03793 1.3e-129 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
NHFKFMEO_03794 5.6e-95 K Bacterial regulatory proteins, tetR family
NHFKFMEO_03795 1.8e-54 yvaE P Small Multidrug Resistance protein
NHFKFMEO_03796 1.3e-72 yvaD S Family of unknown function (DUF5360)
NHFKFMEO_03797 0.0 yvaC S Fusaric acid resistance protein-like
NHFKFMEO_03798 2.4e-118 azoR I Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NHFKFMEO_03799 3.1e-195 yvaA 1.1.1.371 S Oxidoreductase
NHFKFMEO_03800 2.2e-48 csoR S transcriptional
NHFKFMEO_03801 1.5e-29 copZ P Copper resistance protein CopZ
NHFKFMEO_03802 0.0 copA 3.6.3.54 P P-type ATPase
NHFKFMEO_03803 0.0 cadA 3.6.3.3, 3.6.3.5 P COG2217 Cation transport ATPase
NHFKFMEO_03804 2.7e-104 bdbD O Thioredoxin
NHFKFMEO_03805 7.2e-71 bdbC O Required for disulfide bond formation in some proteins
NHFKFMEO_03806 4.1e-107 yvgT S membrane
NHFKFMEO_03807 0.0 helD 3.6.4.12 L DNA helicase
NHFKFMEO_03808 0.0 cysJ 1.8.1.2 P Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NHFKFMEO_03809 0.0 cysI 1.7.7.1, 1.8.1.2, 1.8.7.1 P Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate
NHFKFMEO_03810 0.0 yjcE P COG0025 NhaP-type Na H and K H antiporters
NHFKFMEO_03811 5.4e-86 yvgO
NHFKFMEO_03812 1.1e-155 yvgN S reductase
NHFKFMEO_03813 4e-119 modB P COG4149 ABC-type molybdate transport system, permease component
NHFKFMEO_03814 3e-134 modA P COG0725 ABC-type molybdate transport system, periplasmic component
NHFKFMEO_03815 1.3e-168 yvgK P COG1910 Periplasmic molybdate-binding protein domain
NHFKFMEO_03816 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
NHFKFMEO_03817 1.7e-84 yvsG S LexA-binding, inner membrane-associated putative hydrolase
NHFKFMEO_03818 6.5e-16 S Small spore protein J (Spore_SspJ)
NHFKFMEO_03819 4.9e-236 yvsH E Arginine ornithine antiporter
NHFKFMEO_03820 6.9e-178 fhuD P ABC transporter
NHFKFMEO_03821 4.6e-183 fhuB P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NHFKFMEO_03822 1.2e-175 fhuG P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NHFKFMEO_03823 4.4e-149 fhuC 3.6.3.34 HP ABC transporter
NHFKFMEO_03824 2e-174 M Efflux transporter rnd family, mfp subunit
NHFKFMEO_03825 1.6e-123 macB V ABC transporter, ATP-binding protein
NHFKFMEO_03826 3.4e-209 yvrN V COG0577 ABC-type antimicrobial peptide transport system, permease component
NHFKFMEO_03827 1.3e-64 yvrL S Regulatory protein YrvL
NHFKFMEO_03828 2.8e-187 oxdC 4.1.1.2 G Oxalate decarboxylase
NHFKFMEO_03829 7e-27 oxdC 4.1.1.2 G Oxalate decarboxylase
NHFKFMEO_03830 2.4e-19 S YvrJ protein family
NHFKFMEO_03831 1.9e-98 yvrI K RNA polymerase
NHFKFMEO_03832 9.4e-23
NHFKFMEO_03833 2.8e-131 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
NHFKFMEO_03834 0.0 T PhoQ Sensor
NHFKFMEO_03835 1.3e-170 yvrE G SMP-30/Gluconolaconase/LRE-like region
NHFKFMEO_03836 9e-139 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
NHFKFMEO_03837 7.6e-169 yvrC P COG0614 ABC-type Fe3 -hydroxamate transport system, periplasmic component
NHFKFMEO_03838 1.7e-185 btuC P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NHFKFMEO_03839 6.4e-246 yvrA 3.6.3.34 HP COG1120 ABC-type cobalamin Fe3 -siderophores transport systems, ATPase components
NHFKFMEO_03840 6.1e-100 yvqK 2.5.1.17 S Adenosyltransferase
NHFKFMEO_03841 1.4e-226 yvqJ EGP Major facilitator Superfamily
NHFKFMEO_03842 5.6e-62 liaI S membrane
NHFKFMEO_03843 2.5e-105 liaH KT COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription
NHFKFMEO_03844 2.5e-121 liaG S Putative adhesin
NHFKFMEO_03845 9.5e-127 yvqF S Cell wall-active antibiotics response 4TMS YvqF
NHFKFMEO_03846 1.6e-186 vraS 2.7.13.3 T Histidine kinase
NHFKFMEO_03847 5.4e-94 vraR KT COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
NHFKFMEO_03848 3e-172 gerAC S Spore germination B3/ GerAC like, C-terminal
NHFKFMEO_03849 2.7e-189 gerAB E Spore germination protein
NHFKFMEO_03850 1.2e-245 gerAA EG Spore germination protein
NHFKFMEO_03851 2.3e-24 S Protein of unknown function (DUF3970)
NHFKFMEO_03852 2.5e-261 fumC 1.1.1.38, 4.2.1.2 C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
NHFKFMEO_03853 4.3e-158 yuxN K Transcriptional regulator
NHFKFMEO_03854 4.3e-250 cssS 2.7.13.3 T PhoQ Sensor
NHFKFMEO_03855 3.4e-126 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
NHFKFMEO_03856 6.8e-235 htrA 3.4.21.107 O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NHFKFMEO_03857 1.2e-79 dps P Ferritin-like domain
NHFKFMEO_03858 8.9e-153 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
NHFKFMEO_03859 3e-299 pepF2 E COG1164 Oligoendopeptidase F
NHFKFMEO_03860 2.5e-66 S YusW-like protein
NHFKFMEO_03861 1e-153 yusV 3.6.3.34 HP ABC transporter
NHFKFMEO_03862 3.8e-47 yusU S Protein of unknown function (DUF2573)
NHFKFMEO_03863 9.7e-158 yusT K LysR substrate binding domain
NHFKFMEO_03864 1.2e-108 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
NHFKFMEO_03865 2.7e-64 yusQ S Tautomerase enzyme
NHFKFMEO_03866 3.8e-293 yusP P Major facilitator superfamily
NHFKFMEO_03867 4.6e-74 yusO K Iron dependent repressor, N-terminal DNA binding domain
NHFKFMEO_03868 7.1e-53 yusN M Coat F domain
NHFKFMEO_03869 5.1e-40
NHFKFMEO_03870 2.2e-165 fadM E Proline dehydrogenase
NHFKFMEO_03871 8.1e-09 S YuzL-like protein
NHFKFMEO_03872 0.0 fadB 1.1.1.35, 4.2.1.17, 5.1.2.3 I 3-hydroxyacyl-CoA dehydrogenase
NHFKFMEO_03873 9.4e-217 fadA 2.3.1.16 I Belongs to the thiolase family
NHFKFMEO_03874 0.0 fadE 1.3.8.1 I acyl-CoA dehydrogenase
NHFKFMEO_03875 2.8e-63 arsC 1.20.4.1 P Belongs to the ArsC family
NHFKFMEO_03876 9.3e-65 gcvH E Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate
NHFKFMEO_03877 4.1e-39 yusG S Protein of unknown function (DUF2553)
NHFKFMEO_03878 1.1e-72 rnmV 3.1.26.8 L COG1658 Small primase-like proteins (Toprim domain)
NHFKFMEO_03879 5.6e-55 traF CO Thioredoxin
NHFKFMEO_03880 3.2e-56 yusD S SCP-2 sterol transfer family
NHFKFMEO_03881 4.8e-185 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NHFKFMEO_03882 1.4e-95 metI P COG2011 ABC-type metal ion transport system, permease component
NHFKFMEO_03883 1.9e-147 metQ P Belongs to the NlpA lipoprotein family
NHFKFMEO_03884 7e-62 yurZ 2.3.1.12, 4.1.1.44 S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NHFKFMEO_03885 8.6e-142 sufC O COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component
NHFKFMEO_03886 9.1e-245 sufD O assembly protein SufD
NHFKFMEO_03887 9.4e-236 sufS 2.8.1.7, 4.4.1.16 E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NHFKFMEO_03888 3.2e-77 nifU C COG0822 NifU homolog involved in Fe-S cluster formation
NHFKFMEO_03889 4.6e-271 sufB O FeS cluster assembly
NHFKFMEO_03890 7.6e-67 yurT E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
NHFKFMEO_03891 1e-41
NHFKFMEO_03893 5.2e-209 yurR 1.4.5.1 E COG0665 Glycine D-amino acid oxidases (deaminating)
NHFKFMEO_03894 2.8e-66 yurQ 2.7.7.7 L COG0322 Nuclease subunit of the excinuclease complex
NHFKFMEO_03895 1.8e-184 frlB M Catalyzes the conversion of a range of fructosamine 6- phosphates to glucose 6-phosphate and a free amino acid
NHFKFMEO_03896 1.3e-240 yurO G COG1653 ABC-type sugar transport system, periplasmic component
NHFKFMEO_03897 5.3e-156 yurN G Binding-protein-dependent transport system inner membrane component
NHFKFMEO_03898 7.3e-169 yurM P COG0395 ABC-type sugar transport system, permease component
NHFKFMEO_03899 3.3e-163 yurL 2.7.1.218 G pfkB family carbohydrate kinase
NHFKFMEO_03900 3.3e-135 yurK K UTRA
NHFKFMEO_03901 4.5e-205 msmX P Belongs to the ABC transporter superfamily
NHFKFMEO_03902 2.4e-169 bsn L Ribonuclease
NHFKFMEO_03903 3.9e-237 pucF 3.5.1.6, 3.5.1.87, 3.5.3.9 E COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases
NHFKFMEO_03904 1.9e-239 pucG 2.6.1.112, 2.6.1.44, 2.6.1.45, 2.6.1.51 E COG0075 Serine-pyruvate aminotransferase archaeal aspartate aminotransferase
NHFKFMEO_03906 4.1e-189 pucA 1.17.1.4 O COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NHFKFMEO_03907 3.4e-109 pucB 1.1.1.328, 1.17.1.4, 2.7.7.76 S MobA-like NTP transferase domain
NHFKFMEO_03908 1.4e-145 ygfM 1.17.1.4, 1.2.5.3 C COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM CutM homologs
NHFKFMEO_03909 0.0 xdhA 1.17.1.4 C COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs
NHFKFMEO_03910 1.4e-95 1.17.1.4, 1.2.5.3, 1.3.99.16 C COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs
NHFKFMEO_03911 2.1e-55 uraH 3.5.2.17, 4.1.1.97 S Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily
NHFKFMEO_03912 1.8e-281 uraD 1.7.3.3, 3.5.1.41, 4.1.1.97 Q Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin
NHFKFMEO_03913 3.3e-223 pbuX F xanthine
NHFKFMEO_03914 3.1e-232 pbuX F Permease family
NHFKFMEO_03915 8.3e-301 pucR QT COG2508 Regulator of polyketide synthase expression
NHFKFMEO_03916 4.3e-258 allB 3.5.2.5 F Catalyzes the conversion of allantoin (5- ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring
NHFKFMEO_03917 2.8e-60 yunG
NHFKFMEO_03918 4.3e-171 yunF S Protein of unknown function DUF72
NHFKFMEO_03919 5.9e-141 yunE S membrane transporter protein
NHFKFMEO_03920 4.1e-264 yunD 3.1.3.5 F Belongs to the 5'-nucleotidase family
NHFKFMEO_03921 1.1e-47 yunC S Domain of unknown function (DUF1805)
NHFKFMEO_03922 8.4e-134 yunB S Sporulation protein YunB (Spo_YunB)
NHFKFMEO_03923 4.5e-196 lytH M Peptidase, M23
NHFKFMEO_03924 1e-167 lipA 2.8.1.8 H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NHFKFMEO_03925 4.1e-110 yutC S Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
NHFKFMEO_03926 9.7e-48 yutD S protein conserved in bacteria
NHFKFMEO_03927 1e-75 yutE S Protein of unknown function DUF86
NHFKFMEO_03928 7.2e-141 nagD 2.7.1.25, 3.1.3.41 G Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
NHFKFMEO_03929 2.5e-77 pgpA 3.1.3.27 I COG1267 Phosphatidylglycerophosphatase A and related proteins
NHFKFMEO_03930 2.9e-198 yutH S Spore coat protein
NHFKFMEO_03931 2.7e-241 hom 1.1.1.3 E homoserine dehydrogenase
NHFKFMEO_03932 2.8e-196 thrC 4.2.3.1 E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NHFKFMEO_03933 4.3e-172 thrB 2.7.1.39 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
NHFKFMEO_03934 0.0 yuxL 3.4.14.5, 3.4.19.1 EU peptidase
NHFKFMEO_03935 1.2e-35 yutI O COG0694 Thioredoxin-like proteins and domains
NHFKFMEO_03936 8.7e-56 yuzD S protein conserved in bacteria
NHFKFMEO_03937 2e-199 yutJ 1.6.99.3 C NADH dehydrogenase
NHFKFMEO_03938 3.2e-39 yuzB S Belongs to the UPF0349 family
NHFKFMEO_03939 5.3e-199 yutK F Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NHFKFMEO_03940 2.2e-162 dapF 5.1.1.7 E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NHFKFMEO_03941 3.7e-63 erpA S Belongs to the HesB IscA family
NHFKFMEO_03942 5.2e-71 paiA 2.3.1.57 K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
NHFKFMEO_03943 2.5e-115 paiB K Putative FMN-binding domain
NHFKFMEO_03944 2.5e-186 guaC 1.1.1.205, 1.7.1.7 F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
NHFKFMEO_03946 1.7e-187 yumC 1.18.1.2, 1.19.1.1 C reductase
NHFKFMEO_03947 2.5e-236 yumB 1.6.99.3 C NADH dehydrogenase
NHFKFMEO_03948 8.4e-27 yuiB S Putative membrane protein
NHFKFMEO_03949 4e-116 yuiC S protein conserved in bacteria
NHFKFMEO_03950 1.2e-77 yuiD S protein conserved in bacteria
NHFKFMEO_03951 7.6e-280 pepA 3.4.11.1, 3.4.11.5 E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NHFKFMEO_03952 3.9e-211 yuiF S antiporter
NHFKFMEO_03953 4.4e-93 bioY S Biotin biosynthesis protein
NHFKFMEO_03954 5.8e-122 yuiH S Oxidoreductase molybdopterin binding domain
NHFKFMEO_03955 1.9e-166 besA S Putative esterase
NHFKFMEO_03956 3.6e-140 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
NHFKFMEO_03957 5.6e-225 entC 5.4.4.2 HQ Isochorismate synthase
NHFKFMEO_03958 0.0 entE 2.7.7.58, 6.3.2.14 Q 2,3-dihydroxybenzoate-AMP ligase
NHFKFMEO_03959 3.1e-178 entB 3.3.2.1, 6.3.2.14 Q Isochorismatase family
NHFKFMEO_03960 0.0 dhbF Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
NHFKFMEO_03961 3.8e-36 mbtH S MbtH-like protein
NHFKFMEO_03962 1.1e-132 yukJ S Uncharacterized conserved protein (DUF2278)
NHFKFMEO_03963 3e-204 ald 1.4.1.1 E Belongs to the AlaDH PNT family
NHFKFMEO_03964 1.9e-228 yukF QT Transcriptional regulator
NHFKFMEO_03965 2.8e-45 esxA S Belongs to the WXG100 family
NHFKFMEO_03966 1.3e-40 yukD S WXG100 protein secretion system (Wss), protein YukD
NHFKFMEO_03967 2.3e-211 essB S WXG100 protein secretion system (Wss), protein YukC
NHFKFMEO_03968 0.0 essC D COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins
NHFKFMEO_03969 0.0 esaA S type VII secretion protein EsaA
NHFKFMEO_03970 3.2e-59 yueC S Family of unknown function (DUF5383)
NHFKFMEO_03971 1.7e-131 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
NHFKFMEO_03972 4.8e-96 yueE S phosphohydrolase
NHFKFMEO_03973 2.9e-24 S Protein of unknown function (DUF2642)
NHFKFMEO_03974 2.9e-66 S Protein of unknown function (DUF2283)
NHFKFMEO_03975 3.2e-190 yueF S transporter activity
NHFKFMEO_03976 2.1e-32 yueG S Spore germination protein gerPA/gerPF
NHFKFMEO_03977 7.4e-39 yueH S YueH-like protein
NHFKFMEO_03978 2.5e-65 yueI S Protein of unknown function (DUF1694)
NHFKFMEO_03979 1.5e-103 pncA Q COG1335 Amidases related to nicotinamidase
NHFKFMEO_03980 3.6e-266 pncB 6.3.4.21 H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NHFKFMEO_03981 2.2e-232 yuxH 3.1.4.52 T signal transduction protein containing EAL and modified HD-GYP domains
NHFKFMEO_03982 1.1e-22 yuzC
NHFKFMEO_03984 5.5e-127 comQ H Belongs to the FPP GGPP synthase family
NHFKFMEO_03986 3.3e-250 comP 2.7.13.3 T Histidine kinase
NHFKFMEO_03987 5.1e-116 comA K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
NHFKFMEO_03988 1.8e-63 ydiI Q protein, possibly involved in aromatic compounds catabolism
NHFKFMEO_03989 5.2e-60 phaG P COG1320 Multisubunit Na H antiporter, MnhG subunit
NHFKFMEO_03990 7.2e-38 phaF P Subunit F of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
NHFKFMEO_03991 1.1e-78 mrpE P Subunit E of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
NHFKFMEO_03992 4.2e-262 mrpD CP Subunit D of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
NHFKFMEO_03993 1.5e-50 phaC 1.6.5.3 P Subunit C of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
NHFKFMEO_03994 1.2e-68 mrpB P Subunit B of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
NHFKFMEO_03995 0.0 phaA 1.6.5.3 CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit
NHFKFMEO_03996 3.2e-14
NHFKFMEO_03997 1.3e-233 maeN C COG3493 Na citrate symporter
NHFKFMEO_03998 1.2e-166 yufQ S Belongs to the binding-protein-dependent transport system permease family
NHFKFMEO_03999 1.9e-184 yufP S Belongs to the binding-protein-dependent transport system permease family
NHFKFMEO_04000 1.6e-272 xylG 3.6.3.17 S ABC transporter, ATP-binding protein
NHFKFMEO_04001 5.8e-197 tcsA S ABC-type transport system, periplasmic component surface lipoprotein
NHFKFMEO_04002 3.9e-125 dcuR T COG4565 Response regulator of citrate malate metabolism
NHFKFMEO_04003 3.8e-293 dcuS 2.7.13.3 T Signal transduction histidine kinase regulating citrate malate metabolism
NHFKFMEO_04004 6.3e-78 yufK S Family of unknown function (DUF5366)
NHFKFMEO_04005 6.3e-75 yuxK S protein conserved in bacteria
NHFKFMEO_04006 0.0 mrcB 2.4.1.129, 3.4.16.4 GT51 M Penicillin-binding Protein
NHFKFMEO_04007 2.1e-183 yuxJ EGP Major facilitator Superfamily
NHFKFMEO_04009 1.9e-115 kapD L the KinA pathway to sporulation
NHFKFMEO_04010 7.4e-70 kapB G Kinase associated protein B
NHFKFMEO_04011 3.9e-232 T PhoQ Sensor
NHFKFMEO_04012 2.1e-224 patB 4.4.1.8 E COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
NHFKFMEO_04013 4.6e-39 yugE S Domain of unknown function (DUF1871)
NHFKFMEO_04014 4.9e-156 yugF I Hydrolase
NHFKFMEO_04015 1.6e-85 alaR K Transcriptional regulator
NHFKFMEO_04016 2.1e-199 yugH 2.6.1.1 E Aminotransferase
NHFKFMEO_04017 8.9e-63 yugI 5.3.1.9 J RNA binding protein (contains ribosomal protein S1 domain)
NHFKFMEO_04018 1.1e-34 yuzA S Domain of unknown function (DUF378)
NHFKFMEO_04019 8.9e-228 yugJ C oxidoreductases, Fe-dependent alcohol dehydrogenase family
NHFKFMEO_04020 2.8e-229 yugK C Dehydrogenase
NHFKFMEO_04021 4.2e-261 pgi 5.3.1.9 G Belongs to the GPI family
NHFKFMEO_04023 1.4e-71 yugN S YugN-like family
NHFKFMEO_04024 1.6e-180 yugO P COG1226 Kef-type K transport systems
NHFKFMEO_04025 1.2e-52 mstX S Membrane-integrating protein Mistic
NHFKFMEO_04026 3.7e-36
NHFKFMEO_04027 1.4e-116 yugP S Zn-dependent protease
NHFKFMEO_04028 1.1e-234 yugS S COG1253 Hemolysins and related proteins containing CBS domains
NHFKFMEO_04029 0.0 yugT 3.2.1.10, 3.2.1.20 GH13,GH31 G COG0366 Glycosidases
NHFKFMEO_04030 2.1e-72 yugU S Uncharacterised protein family UPF0047
NHFKFMEO_04031 6.7e-35
NHFKFMEO_04032 9.9e-140 tgl 2.3.2.13 S protein-glutamine gamma-glutamyltransferase activity
NHFKFMEO_04033 3.2e-225 mcpA NT chemotaxis protein
NHFKFMEO_04034 6.9e-220 mcpA NT chemotaxis protein
NHFKFMEO_04035 3.2e-294 mcpA NT chemotaxis protein
NHFKFMEO_04036 7.3e-238 mcpA NT chemotaxis protein

eggNOG-mapper v2 (Database: eggNOG v5.0, Jul. 2018 release)