ORF_ID e_value Gene_name EC_number CAZy COGs Description
HAFHEPHE_00002 2e-25 K Transcriptional regulator, TetR family
HAFHEPHE_00003 1.8e-37 L hmm pf00665
HAFHEPHE_00007 5.2e-89 L hmm pf00665
HAFHEPHE_00008 2.1e-134 L hmm pf00665
HAFHEPHE_00009 3.3e-64 XK27_01125 L PFAM IS66 Orf2 family protein
HAFHEPHE_00011 5e-72 L Helix-turn-helix domain
HAFHEPHE_00012 7.7e-100 L Helix-turn-helix domain
HAFHEPHE_00013 9.3e-19
HAFHEPHE_00015 1.8e-154 csd1 3.5.1.28 G domain, Protein
HAFHEPHE_00016 7.7e-33 L Helix-turn-helix domain
HAFHEPHE_00017 1.6e-39 L Transposase
HAFHEPHE_00018 8.8e-95 L 4.5 Transposon and IS
HAFHEPHE_00019 8.5e-173 L Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
HAFHEPHE_00020 2.3e-259 S Uncharacterised protein family (UPF0236)
HAFHEPHE_00024 1.7e-246 yifK E Amino acid permease
HAFHEPHE_00025 1.5e-180 L transposase, IS605 OrfB family
HAFHEPHE_00026 5.1e-09 L transposase, IS605 OrfB family
HAFHEPHE_00027 2.1e-60 L PFAM transposase IS200-family protein
HAFHEPHE_00028 2.4e-77 K LytTr DNA-binding domain
HAFHEPHE_00029 1e-67 S Protein of unknown function (DUF3021)
HAFHEPHE_00030 8e-155 3.2.1.96, 3.5.1.28 GH73 M N-acetylmuramoyl-L-alanine amidase
HAFHEPHE_00031 1.5e-277 O Arylsulfotransferase (ASST)
HAFHEPHE_00032 4e-213 acm2 3.2.1.17 NU Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
HAFHEPHE_00034 7e-209 yxjG_1 E methionine synthase, vitamin-B12 independent
HAFHEPHE_00035 7.8e-41 S Cytochrome B5
HAFHEPHE_00036 2.5e-176 iolT EGP Major facilitator Superfamily
HAFHEPHE_00037 9.4e-24 S PFAM Archaeal ATPase
HAFHEPHE_00038 0.0 kup P Transport of potassium into the cell
HAFHEPHE_00039 2.1e-08 tnp L MULE transposase domain
HAFHEPHE_00040 9.1e-212 3.6.4.12 L DnaB-like helicase C terminal domain
HAFHEPHE_00041 2.2e-164 L PFAM Integrase, catalytic core
HAFHEPHE_00042 3.8e-83 L Bacterial dnaA protein
HAFHEPHE_00043 3.3e-22 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
HAFHEPHE_00044 1.9e-29 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
HAFHEPHE_00045 8.8e-164 S reductase
HAFHEPHE_00046 2e-36 L PFAM transposase, IS204 IS1001 IS1096 IS1165 family protein
HAFHEPHE_00047 3.1e-114 L PFAM transposase, IS204 IS1001 IS1096 IS1165 family protein
HAFHEPHE_00048 7.2e-153 glcU U sugar transport
HAFHEPHE_00049 0.0 uvrA2 L ABC transporter
HAFHEPHE_00050 3.5e-160
HAFHEPHE_00051 1e-72 K Transcriptional regulator
HAFHEPHE_00052 1.2e-188 D Alpha beta
HAFHEPHE_00053 4.9e-52 ypaA S Protein of unknown function (DUF1304)
HAFHEPHE_00054 0.0 poxB 1.2.3.3, 1.2.5.1 EH Belongs to the TPP enzyme family
HAFHEPHE_00055 3.5e-33 cinA 3.5.1.42 S Competence-damaged protein
HAFHEPHE_00056 2.1e-70 repA S Replication initiator protein A
HAFHEPHE_00057 3.4e-109 nanH 4.1.3.3, 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HAFHEPHE_00058 7.8e-260 gor 1.8.1.7 C Glutathione reductase
HAFHEPHE_00059 2.2e-168
HAFHEPHE_00060 5.4e-98 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HAFHEPHE_00061 2.8e-178 S Phosphotransferase system, EIIC
HAFHEPHE_00062 2.6e-85 dps P Belongs to the Dps family
HAFHEPHE_00063 1.1e-74 pacL 3.6.3.8 P P-type ATPase
HAFHEPHE_00064 0.0 pacL 3.6.3.8 P P-type ATPase
HAFHEPHE_00065 9.2e-172 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 G Responsible for synthesis of pseudouridine from uracil
HAFHEPHE_00066 7.3e-152 nadK 2.7.1.23 F Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HAFHEPHE_00067 5.2e-116 yjbM 2.7.6.5 S RelA SpoT domain protein
HAFHEPHE_00068 1.2e-112 yjbH Q Thioredoxin
HAFHEPHE_00069 4.5e-234 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
HAFHEPHE_00070 4.4e-74 rplI J Binds to the 23S rRNA
HAFHEPHE_00071 0.0 yybT T signaling protein consisting of a modified GGDEF domain and a DHH domain
HAFHEPHE_00072 0.0 fusA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HAFHEPHE_00073 2.4e-83 rpsG J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
HAFHEPHE_00074 3.9e-72 rpsL J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HAFHEPHE_00075 4.1e-116 pilD 3.4.23.43 NOU Bacterial Peptidase A24 N-terminal domain
HAFHEPHE_00076 1.4e-264 npr 1.11.1.1 C NADH oxidase
HAFHEPHE_00077 4.1e-68 S pyridoxamine 5-phosphate
HAFHEPHE_00078 1.3e-53 tnp2PF3 L Putative transposase of IS4/5 family (DUF4096)
HAFHEPHE_00081 3.8e-159 metQ_4 P Belongs to the nlpA lipoprotein family
HAFHEPHE_00082 2.6e-88 luxS 4.4.1.21 H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
HAFHEPHE_00083 2.7e-123 O Zinc-dependent metalloprotease
HAFHEPHE_00084 8.1e-111 S Membrane
HAFHEPHE_00085 2.5e-95 adh 1.1.1.1, 1.1.1.14 E alcohol dehydrogenase
HAFHEPHE_00086 1.7e-44 adh 1.1.1.1, 1.1.1.14 E alcohol dehydrogenase
HAFHEPHE_00087 4.1e-29 adh 1.1.1.1, 1.1.1.14 E alcohol dehydrogenase
HAFHEPHE_00091 1e-225 yhdG E C-terminus of AA_permease
HAFHEPHE_00092 3e-20 uspA T Universal stress protein family
HAFHEPHE_00093 1.6e-117 L Integrase
HAFHEPHE_00094 3.6e-157 rssA S Phospholipase, patatin family
HAFHEPHE_00095 2.7e-206 sacB 2.4.1.10, 2.4.1.9, 3.2.1.26 GH32,GH68 M Levansucrase/Invertase
HAFHEPHE_00096 1.7e-201 xerS L Belongs to the 'phage' integrase family
HAFHEPHE_00098 3.6e-249 serS 6.1.1.11 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HAFHEPHE_00099 5.2e-265 glnP P ABC transporter
HAFHEPHE_00100 1.4e-138 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
HAFHEPHE_00101 2.5e-39 nox C NADH oxidase
HAFHEPHE_00102 1.9e-142 nox C NADH oxidase
HAFHEPHE_00103 4e-26 nox C NADH oxidase
HAFHEPHE_00104 8.1e-171 nox C NADH oxidase
HAFHEPHE_00105 8.6e-159 EG EamA-like transporter family
HAFHEPHE_00106 0.0 ltaS 2.7.8.20 M Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
HAFHEPHE_00107 5.4e-275 gnd 1.1.1.343, 1.1.1.44 H Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HAFHEPHE_00108 8.3e-287 zwf 1.1.1.363, 1.1.1.49 G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HAFHEPHE_00109 1.7e-191 yeaN P Transporter, major facilitator family protein
HAFHEPHE_00110 1.3e-72 S 3-demethylubiquinone-9 3-methyltransferase
HAFHEPHE_00111 9.9e-85 nrdI F Belongs to the NrdI family
HAFHEPHE_00113 3.1e-130 K response regulator
HAFHEPHE_00114 0.0 vicK 2.7.13.3 T Histidine kinase
HAFHEPHE_00115 2.5e-247 yycH S YycH protein
HAFHEPHE_00116 9.3e-150 yycI S YycH protein
HAFHEPHE_00117 6.6e-153 vicX 3.1.26.11 S domain protein
HAFHEPHE_00118 0.0 helD 3.6.4.12 L DNA helicase
HAFHEPHE_00119 9.7e-115 dedA S SNARE associated Golgi protein
HAFHEPHE_00120 2.5e-126 3.1.3.73 G phosphoglycerate mutase
HAFHEPHE_00121 1.2e-228 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HAFHEPHE_00122 1.4e-10
HAFHEPHE_00123 4.1e-127 gntR1 K UbiC transcription regulator-associated domain protein
HAFHEPHE_00124 7.7e-285 pncB 6.3.4.21 F Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HAFHEPHE_00125 1.7e-151 nadE 6.3.1.5 F Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
HAFHEPHE_00126 0.0 yhgF K Tex-like protein N-terminal domain protein
HAFHEPHE_00127 9.6e-85 ydcK S Belongs to the SprT family
HAFHEPHE_00129 1.3e-87 dut S Protein conserved in bacteria
HAFHEPHE_00130 5e-182
HAFHEPHE_00131 8.8e-151
HAFHEPHE_00132 1.4e-50 S Iron-sulfur cluster assembly protein
HAFHEPHE_00133 2.1e-99 msrA 1.8.4.11, 1.8.4.12 C Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HAFHEPHE_00134 6.6e-151 P Belongs to the nlpA lipoprotein family
HAFHEPHE_00135 3.9e-12
HAFHEPHE_00136 5.5e-217 patA 2.6.1.1, 2.6.1.57 E Aminotransferase
HAFHEPHE_00137 6.6e-70 yqeY S YqeY-like protein
HAFHEPHE_00138 1.2e-23 rpsU J Belongs to the bacterial ribosomal protein bS21 family
HAFHEPHE_00139 5.3e-265 glnPH2 P ABC transporter permease
HAFHEPHE_00140 2.9e-131 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
HAFHEPHE_00141 0.0 aspS 6.1.1.12 J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
HAFHEPHE_00142 5.3e-169 yniA G Phosphotransferase enzyme family
HAFHEPHE_00143 3.7e-35 hxlR K regulation of RNA biosynthetic process
HAFHEPHE_00144 1.1e-164 G Belongs to the carbohydrate kinase PfkB family
HAFHEPHE_00145 1.4e-245 F Belongs to the purine-cytosine permease (2.A.39) family
HAFHEPHE_00146 2e-205 yegU O ADP-ribosylglycohydrolase
HAFHEPHE_00147 6.5e-47 pncA Q Isochorismatase family
HAFHEPHE_00148 1.6e-45 pncA Q Isochorismatase family
HAFHEPHE_00149 3.6e-271 pncB 6.3.4.21 F Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HAFHEPHE_00150 2.2e-131 3.6.1.13, 3.6.1.55 F NUDIX domain
HAFHEPHE_00151 5.1e-81 uspA T universal stress protein
HAFHEPHE_00152 0.0 tetP J elongation factor G
HAFHEPHE_00153 3.1e-16 tetP J elongation factor G
HAFHEPHE_00154 9.9e-166 GK ROK family
HAFHEPHE_00155 1.1e-234 brnQ U Component of the transport system for branched-chain amino acids
HAFHEPHE_00156 2.1e-137 aroD S Serine hydrolase (FSH1)
HAFHEPHE_00157 6.3e-241 yagE E amino acid
HAFHEPHE_00158 4.7e-35 rpsR J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HAFHEPHE_00159 3.1e-77 ssb L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
HAFHEPHE_00160 1.2e-48 rpsF J Binds together with S18 to 16S ribosomal RNA
HAFHEPHE_00161 0.0 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HAFHEPHE_00162 0.0 gyrB 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HAFHEPHE_00163 5.5e-206 recF L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HAFHEPHE_00164 1.7e-34 yaaA S S4 domain protein YaaA
HAFHEPHE_00165 1.7e-176 coaA 2.7.1.33 F Pantothenic acid kinase
HAFHEPHE_00166 1.7e-218 S cog cog1373
HAFHEPHE_00168 6.2e-301 guaA 2.3.1.128, 6.3.5.2 F Catalyzes the synthesis of GMP from XMP
HAFHEPHE_00169 4.1e-223 oxlT P Major Facilitator Superfamily
HAFHEPHE_00170 2.1e-160 spoU 2.1.1.185 J Methyltransferase
HAFHEPHE_00171 2.3e-87 ywlG S Belongs to the UPF0340 family
HAFHEPHE_00172 5.7e-172 scrR K Transcriptional regulator, LacI family
HAFHEPHE_00173 8.6e-24
HAFHEPHE_00174 9.6e-104
HAFHEPHE_00175 5.6e-217 yttB EGP Major facilitator Superfamily
HAFHEPHE_00176 5.7e-244 hisS 6.1.1.21 J histidyl-tRNA synthetase
HAFHEPHE_00177 3.1e-89
HAFHEPHE_00178 2.7e-109 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX
HAFHEPHE_00179 8.6e-176 S Putative peptidoglycan binding domain
HAFHEPHE_00180 1.7e-19 S Putative peptidoglycan binding domain
HAFHEPHE_00181 0.0 copA 3.6.3.54 P P-type ATPase
HAFHEPHE_00182 7e-49 silP 1.9.3.1, 3.6.3.54 S Cupredoxin-like domain
HAFHEPHE_00183 2.9e-55 silP 1.9.3.1, 3.6.3.54 S Cupredoxin-like domain
HAFHEPHE_00184 1.9e-101 XK27_08875 O PFAM peptidase M10A and M12B, matrixin and adamalysin
HAFHEPHE_00185 9.6e-161 EG EamA-like transporter family
HAFHEPHE_00186 2.1e-171 arcC 2.7.2.2 E Belongs to the carbamate kinase family
HAFHEPHE_00187 7.6e-191 argF 2.1.3.3 E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HAFHEPHE_00188 1.6e-154 KT YcbB domain
HAFHEPHE_00190 9.5e-242 yhdP S Transporter associated domain
HAFHEPHE_00191 1.3e-154 ypdB V (ABC) transporter
HAFHEPHE_00192 5.7e-89 GM epimerase
HAFHEPHE_00193 1.1e-89 M1-874 K Domain of unknown function (DUF1836)
HAFHEPHE_00194 2.3e-78 yybA 2.3.1.57 K Transcriptional regulator
HAFHEPHE_00195 5.5e-135 XK27_07210 6.1.1.6 S B3 4 domain
HAFHEPHE_00196 4.9e-167 S AI-2E family transporter
HAFHEPHE_00197 1.5e-155 3.2.1.52 GH20 G Xylose isomerase domain protein TIM barrel
HAFHEPHE_00198 1.3e-157
HAFHEPHE_00199 1.8e-130 glpF U Belongs to the MIP aquaporin (TC 1.A.8) family
HAFHEPHE_00200 9.9e-291 clcA P chloride
HAFHEPHE_00201 1.8e-34 secG U Preprotein translocase
HAFHEPHE_00202 3.7e-145 est 3.1.1.1 S Serine aminopeptidase, S33
HAFHEPHE_00203 0.0 rnr J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
HAFHEPHE_00204 1.4e-83 smpB J the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
HAFHEPHE_00205 1.7e-102 yxjI
HAFHEPHE_00206 2.4e-135 ung 3.2.2.27 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HAFHEPHE_00207 1.1e-178 pta 2.3.1.8, 3.6.3.21 C phosphate acetyltransferase
HAFHEPHE_00208 2.5e-80 ydiB 2.7.1.221, 5.1.1.1 O Hydrolase, P-loop family
HAFHEPHE_00209 1.1e-84 K Acetyltransferase (GNAT) domain
HAFHEPHE_00210 6e-149 2.3.1.19 K Helix-turn-helix XRE-family like proteins
HAFHEPHE_00211 6.5e-15 araP U Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family
HAFHEPHE_00212 4.7e-227 araP U Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family
HAFHEPHE_00213 2.2e-311 araB 2.7.1.16 G carbohydrate kinase FGGY
HAFHEPHE_00214 3.5e-134 araD 4.1.2.17, 5.1.3.4 G links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source
HAFHEPHE_00215 6.4e-273 araA 5.3.1.4 G Catalyzes the conversion of L-arabinose to L-ribulose
HAFHEPHE_00216 6.4e-94 maa 2.3.1.79 S Maltose O-acetyltransferase
HAFHEPHE_00217 2.4e-153 ytbE 1.1.1.346 S Aldo keto reductase
HAFHEPHE_00218 1e-204 araR K Transcriptional regulator
HAFHEPHE_00222 7.4e-66
HAFHEPHE_00224 1.3e-51
HAFHEPHE_00225 9.1e-34
HAFHEPHE_00226 1.6e-124 gp17a S Terminase-like family
HAFHEPHE_00227 1.4e-36 gp17a S Terminase-like family
HAFHEPHE_00228 7.2e-19
HAFHEPHE_00230 6.6e-09 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
HAFHEPHE_00231 2e-135 S Psort location CytoplasmicMembrane, score
HAFHEPHE_00232 8.3e-40 L PFAM Integrase catalytic region
HAFHEPHE_00234 0.0 3.2.1.17 NU Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
HAFHEPHE_00235 3.2e-161 rfbA 2.7.7.24 H Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HAFHEPHE_00236 2.7e-108 rfbC 5.1.3.13 M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
HAFHEPHE_00237 2.5e-197 rfbB 4.2.1.46 M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
HAFHEPHE_00238 4.7e-154 rfbD 1.1.1.133, 5.1.3.13 M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
HAFHEPHE_00239 0.0 xfp 4.1.2.22, 4.1.2.9 G Phosphoketolase
HAFHEPHE_00240 1.6e-134 gntR K UbiC transcription regulator-associated domain protein
HAFHEPHE_00241 1.5e-86 ybaK J Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HAFHEPHE_00242 1.3e-281 pipD E Dipeptidase
HAFHEPHE_00243 0.0 yfiC V ABC transporter
HAFHEPHE_00244 1e-307 lmrA V ABC transporter, ATP-binding protein
HAFHEPHE_00245 3.2e-189 ldhA 1.1.1.28 C Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HAFHEPHE_00246 0.0 yjcE P Sodium proton antiporter
HAFHEPHE_00247 4.7e-52 yvlA
HAFHEPHE_00248 2.9e-111 P Cobalt transport protein
HAFHEPHE_00249 1.2e-242 cbiO1 S ABC transporter, ATP-binding protein
HAFHEPHE_00250 1e-96 S ABC-type cobalt transport system, permease component
HAFHEPHE_00251 3.6e-132 S membrane transporter protein
HAFHEPHE_00252 4.3e-138 IQ KR domain
HAFHEPHE_00253 9.5e-183 iunH2 3.2.2.1 F nucleoside hydrolase
HAFHEPHE_00254 3e-179 yumC 1.18.1.2, 1.19.1.1, 1.8.1.9 C Ferredoxin--NADP reductase
HAFHEPHE_00255 8.4e-49 S Double zinc ribbon
HAFHEPHE_00256 3.3e-13 S Double zinc ribbon
HAFHEPHE_00257 5e-83 T GHKL domain
HAFHEPHE_00258 4.3e-83 usp6 T universal stress protein
HAFHEPHE_00259 5.7e-46
HAFHEPHE_00260 1.3e-240 rarA L recombination factor protein RarA
HAFHEPHE_00261 7.4e-75 yueI S Protein of unknown function (DUF1694)
HAFHEPHE_00262 1.6e-21
HAFHEPHE_00263 6.8e-74 4.4.1.5 E Glyoxalase
HAFHEPHE_00264 9.4e-138 S Membrane
HAFHEPHE_00265 2.5e-138 S Belongs to the UPF0246 family
HAFHEPHE_00266 0.0 oxc 4.1.1.8 EH Belongs to the TPP enzyme family
HAFHEPHE_00267 3.3e-258 frc 2.8.3.16 C Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate
HAFHEPHE_00268 1.8e-235 pbuG S permease
HAFHEPHE_00269 4.2e-118 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HAFHEPHE_00270 1.3e-251 mpl 6.3.2.4, 6.3.2.45, 6.3.2.8 M Belongs to the MurCDEF family
HAFHEPHE_00271 1.4e-119 ybhL S Belongs to the BI1 family
HAFHEPHE_00272 3.1e-72 yoaK S Protein of unknown function (DUF1275)
HAFHEPHE_00273 1e-15 yoaK S Protein of unknown function (DUF1275)
HAFHEPHE_00274 0.0 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HAFHEPHE_00275 2.2e-156 fpg 3.2.2.23, 4.2.99.18 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
HAFHEPHE_00276 1.3e-97 coaE 2.7.1.24 F Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HAFHEPHE_00277 1.1e-80 nrdR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HAFHEPHE_00278 1.4e-224 dnaB L replication initiation and membrane attachment
HAFHEPHE_00279 2.8e-171 dnaI L Primosomal protein DnaI
HAFHEPHE_00280 3.7e-85 infC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HAFHEPHE_00281 2.3e-27 rpmI J Belongs to the bacterial ribosomal protein bL35 family
HAFHEPHE_00282 3.3e-56 rplT J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HAFHEPHE_00283 8.8e-35 yphJ 4.1.1.44 S decarboxylase
HAFHEPHE_00284 1.9e-83 C Flavodoxin
HAFHEPHE_00285 2.1e-149 K Transcriptional regulator
HAFHEPHE_00286 2.3e-53 lacA S transferase hexapeptide repeat
HAFHEPHE_00288 1.5e-142 S Alpha beta hydrolase
HAFHEPHE_00289 2.3e-153 tesE Q hydratase
HAFHEPHE_00290 3.8e-176 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
HAFHEPHE_00291 2.7e-227 aadAT EK Aminotransferase, class I
HAFHEPHE_00292 1.1e-154 ypuA S Protein of unknown function (DUF1002)
HAFHEPHE_00293 4.8e-182 ansA 3.5.1.1 EJ L-asparaginase, type I
HAFHEPHE_00294 3.7e-88 K Transcriptional regulator
HAFHEPHE_00295 3.4e-36 K Transcriptional regulator
HAFHEPHE_00296 2.1e-160 akr5f 1.1.1.346 S reductase
HAFHEPHE_00297 2.2e-63 yneR
HAFHEPHE_00298 1.1e-124 yfeJ 6.3.5.2 F glutamine amidotransferase
HAFHEPHE_00299 2.7e-293 lysS 6.1.1.6 J Belongs to the class-II aminoacyl-tRNA synthetase family
HAFHEPHE_00300 5.4e-189 dus J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HAFHEPHE_00301 5.2e-170 hslO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HAFHEPHE_00302 0.0 ftsH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HAFHEPHE_00303 1.7e-96 hpt 2.4.2.8 F Belongs to the purine pyrimidine phosphoribosyltransferase family
HAFHEPHE_00304 4.8e-252 tilS 2.4.2.8, 6.3.4.19 J Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
HAFHEPHE_00305 9.8e-67 yabR J RNA binding
HAFHEPHE_00306 2.3e-57 divIC D Septum formation initiator
HAFHEPHE_00307 8.1e-39 yabO J S4 domain protein
HAFHEPHE_00308 0.0 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HAFHEPHE_00309 4.3e-103 pth 3.1.1.29 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
HAFHEPHE_00310 1.1e-113 S (CBS) domain
HAFHEPHE_00311 9.6e-118 L HNH endonuclease
HAFHEPHE_00312 2.9e-103 2.1.1.72 S Adenine-specific methyltransferase EcoRI
HAFHEPHE_00313 7.8e-147 GT89 M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HAFHEPHE_00314 2e-17 S Bacterial membrane protein, YfhO
HAFHEPHE_00315 7e-40
HAFHEPHE_00317 6.9e-63 S Homeodomain-like domain
HAFHEPHE_00319 7.7e-98 D Cellulose biosynthesis protein BcsQ
HAFHEPHE_00320 1.8e-96 xerC L Phage integrase, N-terminal SAM-like domain
HAFHEPHE_00321 5.8e-30 L Replication protein
HAFHEPHE_00322 1.7e-16 L Replication protein
HAFHEPHE_00323 2.5e-104 pre D plasmid recombination enzyme
HAFHEPHE_00326 6.7e-75 3.6.4.12 L DnaB-like helicase C terminal domain
HAFHEPHE_00327 3.4e-106 L Phage integrase family
HAFHEPHE_00328 8e-42 S RelB antitoxin
HAFHEPHE_00329 1.6e-51 S Bacterial toxin of type II toxin-antitoxin system, YafQ
HAFHEPHE_00330 3.9e-157 S Abortive infection C-terminus
HAFHEPHE_00331 0.0 res_1 3.1.21.5 L Type III restriction enzyme, res subunit
HAFHEPHE_00332 6.8e-225 sthIM 2.1.1.72 L DNA methylase
HAFHEPHE_00333 8.5e-67 S Protein of unknown function, DUF536
HAFHEPHE_00335 2.5e-158 L Lactococcus lactis RepB C-terminus
HAFHEPHE_00337 1.8e-19 XK27_09990 D Fic/DOC family
HAFHEPHE_00338 2.8e-29 XK27_09990 D Fic/DOC family
HAFHEPHE_00339 6.9e-110
HAFHEPHE_00340 1.2e-198 D Relaxase/Mobilisation nuclease domain
HAFHEPHE_00341 6.2e-58 mobC S Bacterial mobilisation protein (MobC)
HAFHEPHE_00342 9.8e-106 L Phage integrase family
HAFHEPHE_00343 8.5e-21 S Plasmid replication protein
HAFHEPHE_00345 3.8e-08 L Initiator Replication protein
HAFHEPHE_00346 3.2e-17 S Replication initiator protein A (RepA) N-terminus
HAFHEPHE_00347 5.4e-70 D CobQ CobB MinD ParA nucleotide binding domain protein
HAFHEPHE_00349 8e-38
HAFHEPHE_00353 9.6e-12 ard S Antirestriction protein (ArdA)
HAFHEPHE_00367 5.5e-21 2.3.1.15 D Antitoxin component of a toxin-antitoxin (TA) module
HAFHEPHE_00368 3e-22 S YoeB-like toxin of bacterial type II toxin-antitoxin system
HAFHEPHE_00369 8.5e-11
HAFHEPHE_00370 7.7e-41 doc S Fic/DOC family
HAFHEPHE_00371 3.5e-108 yvrI K sigma factor activity
HAFHEPHE_00372 1.3e-197 G Transporter, major facilitator family protein
HAFHEPHE_00373 0.0 S Bacterial membrane protein YfhO
HAFHEPHE_00374 3.6e-102 T Ion transport 2 domain protein
HAFHEPHE_00375 7.4e-77 ribH 2.5.1.78 H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
HAFHEPHE_00376 5.7e-222 ribBA 3.5.4.25, 4.1.99.12 H Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate
HAFHEPHE_00377 3.9e-94 ribE 2.5.1.9, 3.5.4.25, 4.1.99.12 H Riboflavin synthase
HAFHEPHE_00378 2.2e-180 ribD 1.1.1.193, 3.5.4.26 H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HAFHEPHE_00379 2.4e-178 rihA 3.2.2.1 F Inosine-uridine preferring nucleoside hydrolase
HAFHEPHE_00381 0.0 L PLD-like domain
HAFHEPHE_00382 5.9e-35 L PLD-like domain
HAFHEPHE_00383 1.1e-95 mrr L restriction endonuclease
HAFHEPHE_00384 3.4e-167 L restriction endonuclease
HAFHEPHE_00385 1.4e-162 rbsK 2.7.1.15 H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HAFHEPHE_00386 5.3e-184 rbsR K Periplasmic binding proteins and sugar binding domain of LacI family
HAFHEPHE_00387 9.4e-112
HAFHEPHE_00388 5e-116 dck 2.7.1.74 F deoxynucleoside kinase
HAFHEPHE_00389 2.7e-105 lmrB EGP Major facilitator Superfamily
HAFHEPHE_00390 2.9e-19 K Transcriptional regulator
HAFHEPHE_00391 6.9e-19 NU Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
HAFHEPHE_00392 2.6e-104 NU Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
HAFHEPHE_00393 7.3e-86 uspA T Belongs to the universal stress protein A family
HAFHEPHE_00394 4e-275 pepV 3.5.1.18 E dipeptidase PepV
HAFHEPHE_00395 4.5e-152 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HAFHEPHE_00396 3.3e-300 ytgP S Polysaccharide biosynthesis protein
HAFHEPHE_00397 7.6e-42
HAFHEPHE_00398 0.0 leuS 6.1.1.4 J Belongs to the class-I aminoacyl-tRNA synthetase family
HAFHEPHE_00399 1.9e-217 metK 2.5.1.6 H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HAFHEPHE_00400 1.8e-93 tag 3.2.2.20 L glycosylase
HAFHEPHE_00401 7.1e-80 XK27_00940 1.2.1.70, 3.5.1.9 S Putative cyclase
HAFHEPHE_00402 7e-153 yxjG 2.1.1.14 E methionine synthase, vitamin-B12 independent
HAFHEPHE_00403 1.4e-253 asnS 6.1.1.22 J Asparaginyl-tRNA synthetase
HAFHEPHE_00404 1.9e-197 asnA 6.3.1.1 F aspartate--ammonia ligase
HAFHEPHE_00405 1.5e-30 yjaB_1 K Acetyltransferase (GNAT) domain
HAFHEPHE_00406 1.8e-88 folT S ECF transporter, substrate-specific component
HAFHEPHE_00407 0.0 pepN 3.4.11.2 E aminopeptidase
HAFHEPHE_00408 4.2e-110 ylbE GM NAD dependent epimerase dehydratase family protein
HAFHEPHE_00409 9.8e-255 pepC 3.4.22.40 E aminopeptidase
HAFHEPHE_00410 8e-208 EGP Major facilitator Superfamily
HAFHEPHE_00411 4.7e-233
HAFHEPHE_00412 1.1e-71 K Transcriptional regulator, HxlR family
HAFHEPHE_00413 1.8e-107 XK27_02070 S Nitroreductase family
HAFHEPHE_00414 8.1e-51 hxlR K Transcriptional regulator, HxlR family
HAFHEPHE_00415 1e-119 GM NmrA-like family
HAFHEPHE_00416 1.3e-73 elaA S Gnat family
HAFHEPHE_00417 7e-39 S Cytochrome B5
HAFHEPHE_00418 7e-175 apbE 2.7.1.180 H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
HAFHEPHE_00419 2.3e-197 XK27_09615 S reductase
HAFHEPHE_00420 6e-100 nqr 1.5.1.36 S reductase
HAFHEPHE_00421 5.9e-266 rumA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HAFHEPHE_00422 5.6e-178 K Transcriptional regulator, LacI family
HAFHEPHE_00423 1e-259 G Major Facilitator
HAFHEPHE_00424 5.8e-205 carA 6.3.5.5 F Carbamoyl-phosphate synthetase glutamine chain
HAFHEPHE_00425 2.3e-310 carB 6.3.5.5 F Carbamoyl-phosphate synthase
HAFHEPHE_00426 6.7e-240 carB 6.3.5.5 F Carbamoyl-phosphate synthase
HAFHEPHE_00427 8.2e-243 G Major Facilitator
HAFHEPHE_00428 9.7e-08 G Major Facilitator
HAFHEPHE_00429 1.8e-161 malL 3.2.1.10 GH13 G Alpha amylase, catalytic domain protein
HAFHEPHE_00430 1.3e-156 malL 3.2.1.10 GH13 G Alpha amylase, catalytic domain protein
HAFHEPHE_00431 9.2e-278 M domain protein
HAFHEPHE_00432 8.8e-61 tagE2 2.4.1.52 GT4 M Poly(Glycerol-phosphate) alpha-glucosyltransferase
HAFHEPHE_00433 7.5e-195 tagE2 2.4.1.52 GT4 M Poly(Glycerol-phosphate) alpha-glucosyltransferase
HAFHEPHE_00434 6.2e-269 tagE3 2.4.1.52 GT4 M Glycosyl transferases group 1
HAFHEPHE_00435 2.2e-72
HAFHEPHE_00436 7.9e-166 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
HAFHEPHE_00437 1.2e-149 thiD 2.5.1.3, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Phosphomethylpyrimidine kinase
HAFHEPHE_00438 0.0 argS 6.1.1.19 J Arginyl-tRNA synthetase
HAFHEPHE_00439 0.0 pbp2A 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
HAFHEPHE_00440 9.4e-38 yheA S Belongs to the UPF0342 family
HAFHEPHE_00441 1.3e-221 yhaO L Ser Thr phosphatase family protein
HAFHEPHE_00442 0.0 L AAA domain
HAFHEPHE_00443 8.5e-128 prsA 5.2.1.8 M Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins
HAFHEPHE_00445 1.2e-76 hit FG histidine triad
HAFHEPHE_00446 3.9e-136 ecsA V ABC transporter, ATP-binding protein
HAFHEPHE_00447 1.1e-217 ecsB U ABC transporter
HAFHEPHE_00448 3.1e-121 trmB 2.1.1.297, 2.1.1.33 J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
HAFHEPHE_00449 2.4e-22 S YSIRK type signal peptide
HAFHEPHE_00450 1.1e-107 2.1.1.72, 3.1.21.3 AA10,CBM73 L Belongs to the N(4) N(6)-methyltransferase family
HAFHEPHE_00451 5.9e-166 2.7.7.7, 3.4.21.110 D Leucine-rich repeat (LRR) protein
HAFHEPHE_00452 1.3e-07 D nuclear chromosome segregation
HAFHEPHE_00453 4.8e-266 tagE 2.4.1.52 GT4 M Glycosyl transferases group 1
HAFHEPHE_00454 3.4e-180 iolS C Aldo keto reductase
HAFHEPHE_00455 1.4e-116 glsA 3.5.1.2 E Belongs to the glutaminase family
HAFHEPHE_00456 7.6e-11 glsA 3.5.1.2 E Belongs to the glutaminase family
HAFHEPHE_00457 2.2e-57 ytzB S Small secreted protein
HAFHEPHE_00458 1.6e-54 ytpP 2.7.1.180, 5.3.4.1 CO Thioredoxin
HAFHEPHE_00461 1.3e-105 wecD3 K PFAM GCN5-related N-acetyltransferase
HAFHEPHE_00462 1.9e-283 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HAFHEPHE_00463 0.0 rexB 3.1.21.3, 3.6.4.12 L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' - 3' nuclease activity
HAFHEPHE_00464 0.0 addA 3.6.4.12 L ATP-dependent helicase nuclease subunit A
HAFHEPHE_00465 1.2e-171 malR K Transcriptional regulator, LacI family
HAFHEPHE_00466 3.6e-208 phbA 2.3.1.9 I Belongs to the thiolase family
HAFHEPHE_00467 6.9e-256 malT G Major Facilitator
HAFHEPHE_00468 0.0 mapA 2.4.1.8 GH65 G hydrolase, family 65, central catalytic
HAFHEPHE_00469 9.3e-121 pgmB 2.4.1.64, 3.1.3.12, 3.2.1.28, 5.4.2.6 GH37,GH65 S beta-phosphoglucomutase
HAFHEPHE_00470 1.7e-71
HAFHEPHE_00471 7.4e-88 2.7.6.5 T Region found in RelA / SpoT proteins
HAFHEPHE_00472 5.8e-115 K response regulator
HAFHEPHE_00473 7.4e-220 sptS 2.7.13.3 T Histidine kinase
HAFHEPHE_00474 4.1e-212 yfeO P Voltage gated chloride channel
HAFHEPHE_00475 2.4e-256 gshF 6.3.2.2 H Belongs to the glutamate--cysteine ligase type 1 family
HAFHEPHE_00476 1.1e-135 puuD S peptidase C26
HAFHEPHE_00477 1.9e-166 yvgN C Aldo keto reductase
HAFHEPHE_00478 1.2e-181 glpQ 3.1.4.46 C Membrane domain of glycerophosphoryl diester phosphodiesterase
HAFHEPHE_00479 2.6e-129 glpQ 3.1.4.46 C Membrane domain of glycerophosphoryl diester phosphodiesterase
HAFHEPHE_00480 7.3e-86 hmpT S ECF-type riboflavin transporter, S component
HAFHEPHE_00481 3.4e-53 L Recombinase
HAFHEPHE_00482 3.2e-204
HAFHEPHE_00483 9.5e-261 rumA 2.1.1.190 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HAFHEPHE_00484 5.6e-186 yegS 2.7.1.107 G Lipid kinase
HAFHEPHE_00485 1.8e-275 gatB 6.1.1.12, 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HAFHEPHE_00486 5.9e-277 gatA 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
HAFHEPHE_00487 1.6e-49 gatC 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HAFHEPHE_00488 3.6e-202 camS S sex pheromone
HAFHEPHE_00489 0.0 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HAFHEPHE_00490 0.0 pcrA 3.6.4.12 L ATP-dependent DNA helicase
HAFHEPHE_00491 9.4e-214 purK2 6.3.4.18 F Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HAFHEPHE_00492 4.6e-100 xpt 2.4.2.22, 2.4.2.7 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
HAFHEPHE_00493 2.3e-113 acmC 3.2.1.96 NU mannosyl-glycoprotein
HAFHEPHE_00494 3.6e-140 IQ reductase
HAFHEPHE_00495 5.6e-65 rpsI J Belongs to the universal ribosomal protein uS9 family
HAFHEPHE_00496 4.5e-79 rplM J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HAFHEPHE_00497 1.2e-140 truA 5.4.99.12 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
HAFHEPHE_00498 1.2e-138 ecfT U Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HAFHEPHE_00499 2.5e-150 ecfA2 3.6.3.55 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HAFHEPHE_00500 5.2e-145 ecfA1 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HAFHEPHE_00501 1.1e-62 rplQ J Ribosomal protein L17
HAFHEPHE_00502 2.8e-171 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HAFHEPHE_00503 1.2e-62 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HAFHEPHE_00504 4.7e-58 rpsM J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HAFHEPHE_00505 1.4e-14 rpmJ J Belongs to the bacterial ribosomal protein bL36 family
HAFHEPHE_00506 1.2e-32 infA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HAFHEPHE_00507 2.3e-124 adk 2.7.4.3 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
HAFHEPHE_00508 8.8e-240 secY U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
HAFHEPHE_00509 8.9e-64 rplO J Binds to the 23S rRNA
HAFHEPHE_00510 2.9e-24 rpmD J Ribosomal protein L30
HAFHEPHE_00511 2.2e-85 rpsE J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HAFHEPHE_00512 6.6e-57 rplR J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HAFHEPHE_00513 2.1e-94 rplF J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HAFHEPHE_00514 1.3e-66 rpsH J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HAFHEPHE_00515 4e-29 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HAFHEPHE_00516 1.4e-95 rplE J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HAFHEPHE_00517 2.6e-49 rplX J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HAFHEPHE_00518 1.1e-59 rplN J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HAFHEPHE_00519 5e-41 rpsQ J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HAFHEPHE_00520 8.4e-28 rpmC J Belongs to the universal ribosomal protein uL29 family
HAFHEPHE_00521 3.5e-76 rplP J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HAFHEPHE_00522 6.1e-112 rpsC J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HAFHEPHE_00523 2.8e-52 rplV J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HAFHEPHE_00524 1.4e-46 rpsS J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HAFHEPHE_00525 2.1e-149 rplB J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HAFHEPHE_00526 1.7e-45 rplW J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
HAFHEPHE_00527 5.5e-107 rplD J Forms part of the polypeptide exit tunnel
HAFHEPHE_00528 1.5e-118 rplC J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HAFHEPHE_00529 3.4e-49 rpsJ J Involved in the binding of tRNA to the ribosomes
HAFHEPHE_00530 2e-31 S Transglycosylase associated protein
HAFHEPHE_00532 2e-180 1.1.1.28 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HAFHEPHE_00533 4.2e-218 V domain protein
HAFHEPHE_00534 3.5e-94 K Transcriptional regulator (TetR family)
HAFHEPHE_00535 4.4e-39 pspC KT PspC domain protein
HAFHEPHE_00536 5.8e-152
HAFHEPHE_00537 4.1e-17 3.2.1.14 GH18
HAFHEPHE_00538 8.1e-81 zur P Belongs to the Fur family
HAFHEPHE_00539 2.8e-97 gmk2 2.7.4.8 F Guanylate kinase
HAFHEPHE_00540 9e-74 apfA 2.7.7.72, 3.6.1.61 F Nudix hydrolase
HAFHEPHE_00541 1.5e-253 yfnA E Amino Acid
HAFHEPHE_00542 5.3e-229 EGP Sugar (and other) transporter
HAFHEPHE_00543 4.9e-38
HAFHEPHE_00544 3.9e-48
HAFHEPHE_00545 2.4e-50
HAFHEPHE_00546 1.6e-207 potD P ABC transporter
HAFHEPHE_00547 7.4e-136 potC P ABC transporter permease
HAFHEPHE_00548 4.3e-144 potB P ABC transporter permease
HAFHEPHE_00549 7.6e-205 potA 3.6.3.30, 3.6.3.31 P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
HAFHEPHE_00550 0.0 pepX 3.4.14.11 E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline
HAFHEPHE_00551 2.3e-178 pip 3.4.11.5 E Releases the N-terminal proline from various substrates
HAFHEPHE_00552 8e-88 rlmH 2.1.1.177 J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HAFHEPHE_00553 6.3e-73 ABC-SBP S ABC transporter
HAFHEPHE_00554 2.5e-57 ABC-SBP S ABC transporter
HAFHEPHE_00555 1.6e-88 pgpA 3.1.3.27 I Phosphatidylglycerophosphatase A
HAFHEPHE_00556 1.6e-217 htrA 3.4.21.107 O serine protease
HAFHEPHE_00557 1.2e-86 G Major Facilitator Superfamily
HAFHEPHE_00558 5.2e-47 G Major Facilitator Superfamily
HAFHEPHE_00559 1.3e-49 G Major Facilitator Superfamily
HAFHEPHE_00560 3.2e-54 rplL J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
HAFHEPHE_00561 1.7e-82 rplJ J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HAFHEPHE_00562 1.8e-209 mnaA 5.1.3.14 G Belongs to the UDP-N-acetylglucosamine 2-epimerase family
HAFHEPHE_00563 1.2e-241 M Glycosyl transferase family group 2
HAFHEPHE_00565 7e-228 aadAT EK Aminotransferase, class I
HAFHEPHE_00566 3e-122 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
HAFHEPHE_00567 1.4e-69 rplK J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HAFHEPHE_00568 3.4e-97 nusG K Participates in transcription elongation, termination and antitermination
HAFHEPHE_00569 1.4e-15 secE U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
HAFHEPHE_00570 1.4e-21 rpmG J Belongs to the bacterial ribosomal protein bL33 family
HAFHEPHE_00571 1.8e-136 rlmB 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HAFHEPHE_00572 7.2e-71 mrnC J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HAFHEPHE_00573 3.8e-273 cysS 6.1.1.16, 6.3.1.13 J Belongs to the class-I aminoacyl-tRNA synthetase family
HAFHEPHE_00574 6.5e-207 yacL S domain protein
HAFHEPHE_00575 7.8e-255 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HAFHEPHE_00576 6.2e-99 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F dUTP diphosphatase
HAFHEPHE_00577 3.8e-50 HA62_12640 S GCN5-related N-acetyl-transferase
HAFHEPHE_00578 2.6e-126 rpiA 2.7.1.12, 5.3.1.6 G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HAFHEPHE_00579 1.5e-266 pepC 3.4.22.40 E Peptidase C1-like family
HAFHEPHE_00580 8.2e-140 tcyA ET Belongs to the bacterial solute-binding protein 3 family
HAFHEPHE_00581 1.4e-133 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
HAFHEPHE_00582 1.1e-119 tcyB E ABC transporter
HAFHEPHE_00583 1.2e-213 metC 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
HAFHEPHE_00584 3.5e-168 I alpha/beta hydrolase fold
HAFHEPHE_00585 1.2e-134 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HAFHEPHE_00586 0.0 S Bacterial membrane protein, YfhO
HAFHEPHE_00587 8.5e-184 lacM 3.2.1.23, 3.2.1.35, 3.2.1.51, 3.2.1.97 GH101,GH29 G beta-galactosidase
HAFHEPHE_00588 0.0 lacL 3.2.1.23 G Belongs to the glycosyl hydrolase 2 family
HAFHEPHE_00589 8.8e-176 pipD E Dipeptidase
HAFHEPHE_00590 6e-76 pipD E Dipeptidase
HAFHEPHE_00591 2.6e-197 mdh 1.1.1.350 C Belongs to the LDH2 MDH2 oxidoreductase family
HAFHEPHE_00593 5.2e-173 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
HAFHEPHE_00595 7.5e-58
HAFHEPHE_00596 6.3e-131 prmA J Ribosomal protein L11 methyltransferase
HAFHEPHE_00597 5.7e-127 rsmE 2.1.1.193 J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
HAFHEPHE_00598 1.8e-51
HAFHEPHE_00599 0.0 relA 2.7.6.5 KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HAFHEPHE_00600 1.3e-75 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
HAFHEPHE_00601 1.9e-46 L Transposase
HAFHEPHE_00605 3e-22 T PemK-like, MazF-like toxin of type II toxin-antitoxin system
HAFHEPHE_00606 4.2e-104 L Belongs to the 'phage' integrase family
HAFHEPHE_00608 5.1e-169 hsdR 3.1.21.3 V Subunit R is required for both nuclease and ATPase activities, but not for modification
HAFHEPHE_00609 4e-125 hsdR 3.1.21.3 V Subunit R is required for both nuclease and ATPase activities, but not for modification
HAFHEPHE_00613 5.9e-08 mrr L Restriction endonuclease
HAFHEPHE_00614 7.3e-95 mrr L restriction endonuclease
HAFHEPHE_00616 3.7e-197 EGP Major facilitator Superfamily
HAFHEPHE_00617 2.5e-120 M Lysin motif
HAFHEPHE_00618 8e-79
HAFHEPHE_00619 1.2e-94 wecD3 K PFAM GCN5-related N-acetyltransferase
HAFHEPHE_00620 3.4e-99 ltrA S Bacterial low temperature requirement A protein (LtrA)
HAFHEPHE_00621 6.9e-204 cytX U Belongs to the purine-cytosine permease (2.A.39) family
HAFHEPHE_00622 4.3e-13
HAFHEPHE_00623 2.8e-66 S Domain of unknown function (DUF4767)
HAFHEPHE_00624 1.3e-136 L Transposase
HAFHEPHE_00625 9.7e-101 L Transposase
HAFHEPHE_00626 0.0 lepA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
HAFHEPHE_00627 7.6e-195 dnaJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
HAFHEPHE_00628 0.0 dnaK O Heat shock 70 kDa protein
HAFHEPHE_00629 3.9e-75 grpE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HAFHEPHE_00630 5.9e-194 hrcA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
HAFHEPHE_00631 5.8e-64
HAFHEPHE_00632 5e-176 ribF 2.7.1.26, 2.7.7.2 H Belongs to the ribF family
HAFHEPHE_00633 2e-166 truB 5.4.99.25 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HAFHEPHE_00634 2.1e-58 rbfA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HAFHEPHE_00635 0.0 infB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HAFHEPHE_00636 1.3e-48 ylxQ J ribosomal protein
HAFHEPHE_00637 1e-44 ylxR K Protein of unknown function (DUF448)
HAFHEPHE_00638 1.8e-215 nusA K Participates in both transcription termination and antitermination
HAFHEPHE_00639 9.4e-83 rimP J Required for maturation of 30S ribosomal subunits
HAFHEPHE_00640 0.0 polC 2.7.7.7 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HAFHEPHE_00641 0.0 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
HAFHEPHE_00642 8.3e-235 rseP 3.4.21.107, 3.4.21.116 M zinc metalloprotease
HAFHEPHE_00643 3.4e-138 cdsA 2.7.7.41 I Belongs to the CDS family
HAFHEPHE_00644 6e-140 uppS 2.5.1.31 H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HAFHEPHE_00645 4.8e-94 frr J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
HAFHEPHE_00646 2e-129 pyrH 2.7.4.22 F Catalyzes the reversible phosphorylation of UMP to UDP
HAFHEPHE_00647 2.1e-152 tsf J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HAFHEPHE_00648 1.2e-143 rpsB J Belongs to the universal ribosomal protein uS2 family
HAFHEPHE_00649 8.6e-179 ldhD 1.1.1.28 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HAFHEPHE_00650 1.6e-48 yazA L GIY-YIG catalytic domain protein
HAFHEPHE_00651 3.5e-140 yabB 2.1.1.223 L Methyltransferase small domain
HAFHEPHE_00652 2.3e-116 plsC 2.3.1.51 I Acyltransferase
HAFHEPHE_00653 4.8e-29 yneF S Uncharacterised protein family (UPF0154)
HAFHEPHE_00654 1.3e-35 ynzC S UPF0291 protein
HAFHEPHE_00655 5.5e-115 lexA 3.4.21.88 K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HAFHEPHE_00656 2.9e-210 mvaS 2.3.3.10 I Hydroxymethylglutaryl-CoA synthase
HAFHEPHE_00657 7.9e-128 rnhA 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HAFHEPHE_00659 1.2e-79 E IrrE N-terminal-like domain
HAFHEPHE_00660 8.8e-45
HAFHEPHE_00661 2e-17
HAFHEPHE_00662 3.3e-09
HAFHEPHE_00664 1.4e-108 L Belongs to the 'phage' integrase family
HAFHEPHE_00674 5.8e-177 hemH 4.99.1.1, 4.99.1.9 H Catalyzes the ferrous insertion into protoporphyrin IX
HAFHEPHE_00675 1.3e-230 mntH P H( )-stimulated, divalent metal cation uptake system
HAFHEPHE_00676 8.1e-144 L PFAM Integrase catalytic region
HAFHEPHE_00677 7.3e-84 L Helix-turn-helix domain
HAFHEPHE_00678 2.1e-78 Q Methyltransferase
HAFHEPHE_00679 3.4e-115 ktrA P domain protein
HAFHEPHE_00680 5e-100 ktrB P Potassium uptake protein
HAFHEPHE_00681 4.5e-60 ktrB P Potassium uptake protein
HAFHEPHE_00682 0.0 mycA 4.2.1.53 S Myosin-crossreactive antigen
HAFHEPHE_00683 6.9e-136 nfrA 1.5.1.38, 1.5.1.39 C nitroreductase
HAFHEPHE_00684 8.8e-212 G Glycosyl hydrolases family 8
HAFHEPHE_00685 2.9e-235 ydaM M Glycosyl transferase
HAFHEPHE_00686 1.4e-56
HAFHEPHE_00687 1.6e-123 phoU P Plays a role in the regulation of phosphate uptake
HAFHEPHE_00688 3.1e-136 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
HAFHEPHE_00689 2.2e-154 pstA P Phosphate transport system permease protein PstA
HAFHEPHE_00690 7.3e-153 pstC P probably responsible for the translocation of the substrate across the membrane
HAFHEPHE_00691 2.5e-158 pstS P Phosphate
HAFHEPHE_00692 2.5e-74 K Transcriptional regulatory protein, C-terminal domain protein
HAFHEPHE_00693 4.7e-134 cbiO P ABC transporter
HAFHEPHE_00694 3.8e-135 P Cobalt transport protein
HAFHEPHE_00695 5.7e-178 nikMN P PDGLE domain
HAFHEPHE_00696 1.3e-159 ureD O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
HAFHEPHE_00697 3.9e-113 ureG KO Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HAFHEPHE_00698 1.7e-125 ureF O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
HAFHEPHE_00699 8.6e-78 ureE O Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HAFHEPHE_00700 0.0 ureC 3.5.1.5 E Amidohydrolase family
HAFHEPHE_00701 1e-60 ureB 3.5.1.5 E Urease beta subunit
HAFHEPHE_00702 1e-41 ureA 3.5.1.5 E Urease, gamma subunit
HAFHEPHE_00703 1.6e-96 ureI S AmiS/UreI family transporter
HAFHEPHE_00704 1.8e-38 P ammonium transporter
HAFHEPHE_00705 1.4e-122 P ammonium transporter
HAFHEPHE_00706 1.6e-31 P ammonium transporter
HAFHEPHE_00708 1.1e-186
HAFHEPHE_00709 9.8e-97 2.3.1.128 K acetyltransferase
HAFHEPHE_00710 4e-83 manA 5.3.1.8 G mannose-6-phosphate isomerase
HAFHEPHE_00711 5.7e-158 K LysR substrate binding domain
HAFHEPHE_00712 1.5e-203 1.1.1.90 C Zn-dependent alcohol dehydrogenases, class III
HAFHEPHE_00713 2.5e-64 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HAFHEPHE_00714 4.6e-26
HAFHEPHE_00715 2.2e-262 pgi 5.3.1.9 G Belongs to the GPI family
HAFHEPHE_00716 1.7e-100 lacA 2.3.1.79 S Transferase hexapeptide repeat
HAFHEPHE_00717 3.1e-153 glcU U sugar transport
HAFHEPHE_00718 6e-269 yclK 2.7.13.3 T Histidine kinase
HAFHEPHE_00719 2.6e-132 K response regulator
HAFHEPHE_00720 2.8e-53 sip L Belongs to the 'phage' integrase family
HAFHEPHE_00721 4.6e-13 K Helix-turn-helix XRE-family like proteins
HAFHEPHE_00722 5.9e-10 S Helix-turn-helix domain
HAFHEPHE_00726 1e-96 S DNA primase
HAFHEPHE_00729 4.3e-16 S Phage head-tail joining protein
HAFHEPHE_00730 1.2e-31 L HNH endonuclease
HAFHEPHE_00731 1.3e-26 terS L Phage terminase, small subunit
HAFHEPHE_00732 3.6e-201 terL S overlaps another CDS with the same product name
HAFHEPHE_00733 7.1e-137 S Phage portal protein
HAFHEPHE_00734 5.2e-186 S Caudovirus prohead serine protease
HAFHEPHE_00735 2.5e-17 S Phage gp6-like head-tail connector protein
HAFHEPHE_00736 1.4e-23
HAFHEPHE_00737 1.5e-08 arpU S Phage transcriptional regulator, ArpU family
HAFHEPHE_00739 1.9e-46
HAFHEPHE_00740 8e-45 L hmm pf00665
HAFHEPHE_00741 4.5e-128 T Calcineurin-like phosphoesterase superfamily domain
HAFHEPHE_00742 4.2e-25
HAFHEPHE_00743 1.4e-61 tnp2PF3 L Putative transposase of IS4/5 family (DUF4096)
HAFHEPHE_00744 1.6e-73 K Copper transport repressor CopY TcrY
HAFHEPHE_00745 0.0 copB 3.6.3.4 P P-type ATPase
HAFHEPHE_00746 1e-38 mdt(A) EGP Major facilitator Superfamily
HAFHEPHE_00748 2.1e-152 D CobQ CobB MinD ParA nucleotide binding domain protein
HAFHEPHE_00749 4.7e-45
HAFHEPHE_00750 5.4e-54 dam 2.1.1.72 L D12 class N6 adenine-specific DNA methyltransferase
HAFHEPHE_00751 9.1e-131 racD 5.1.1.13 M Belongs to the aspartate glutamate racemases family
HAFHEPHE_00752 1.5e-300 aspT P Predicted Permease Membrane Region
HAFHEPHE_00753 2.5e-248 EGP Major facilitator Superfamily
HAFHEPHE_00754 8.5e-111
HAFHEPHE_00757 2.3e-34 yjjH S Calcineurin-like phosphoesterase
HAFHEPHE_00758 4.8e-92 yjjH S Calcineurin-like phosphoesterase
HAFHEPHE_00759 1.8e-154 dtpT U amino acid peptide transporter
HAFHEPHE_00760 8.5e-82 dtpT U amino acid peptide transporter
HAFHEPHE_00761 8.3e-19
HAFHEPHE_00763 1.1e-13 K Cro/C1-type HTH DNA-binding domain
HAFHEPHE_00767 4.4e-09 S head-tail joining protein
HAFHEPHE_00768 4.4e-13 terS L Phage terminase, small subunit
HAFHEPHE_00769 1.9e-65 S Phage portal protein
HAFHEPHE_00770 9.9e-115 S Phage capsid family
HAFHEPHE_00771 1e-09 S Phage gp6-like head-tail connector protein
HAFHEPHE_00772 1.2e-67 yqkB S Belongs to the HesB IscA family
HAFHEPHE_00773 2.3e-173 ppaC 3.6.1.1 C inorganic pyrophosphatase
HAFHEPHE_00774 3.5e-82 F NUDIX domain
HAFHEPHE_00775 0.0 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HAFHEPHE_00776 1.2e-103 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HAFHEPHE_00777 0.0 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HAFHEPHE_00778 1.5e-107 plsY 2.3.1.15, 3.5.1.104 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
HAFHEPHE_00779 1.6e-168 lacX 5.1.3.3 G Aldose 1-epimerase
HAFHEPHE_00780 0.0 topA 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HAFHEPHE_00781 7.1e-161 dprA LU DNA protecting protein DprA
HAFHEPHE_00782 3.6e-140 rnhB 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HAFHEPHE_00783 8.4e-162 ylqF S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HAFHEPHE_00784 4.4e-35 yozE S Belongs to the UPF0346 family
HAFHEPHE_00785 2.2e-108 ypmS S Uncharacterized protein conserved in bacteria (DUF2140)
HAFHEPHE_00786 8.3e-168 ypmR E lipolytic protein G-D-S-L family
HAFHEPHE_00787 2.2e-151 DegV S EDD domain protein, DegV family
HAFHEPHE_00788 4.5e-112 hlyIII S protein, hemolysin III
HAFHEPHE_00789 1.2e-88 folA 1.5.1.3 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HAFHEPHE_00790 7.2e-191 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HAFHEPHE_00791 0.0 yfmR S ABC transporter, ATP-binding protein
HAFHEPHE_00792 6.9e-223 cca 2.7.7.19, 2.7.7.72 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HAFHEPHE_00793 1.5e-236 S Tetratricopeptide repeat protein
HAFHEPHE_00794 2.6e-40 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
HAFHEPHE_00795 4.9e-246 der 1.1.1.399, 1.1.1.95 S GTPase that plays an essential role in the late steps of ribosome biogenesis
HAFHEPHE_00796 1.4e-205 rpsA 1.17.7.4 J Ribosomal protein S1
HAFHEPHE_00797 7.6e-118 cmk 1.17.7.4, 2.5.1.19, 2.7.1.26, 2.7.4.25, 2.7.7.2, 6.3.2.1 F Belongs to the cytidylate kinase family. Type 1 subfamily
HAFHEPHE_00798 7.2e-13 M Lysin motif
HAFHEPHE_00799 1e-265 recQ1 3.6.4.12 L ATP-dependent DNA helicase RecQ
HAFHEPHE_00800 7.7e-191 ypbB 5.1.3.1 S Helix-turn-helix domain
HAFHEPHE_00801 2.6e-103 U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HAFHEPHE_00802 8.4e-128 rluB 5.4.99.19, 5.4.99.21, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
HAFHEPHE_00803 1.7e-105 scpB D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HAFHEPHE_00804 2.2e-137 scpA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HAFHEPHE_00805 1.5e-64 ribT K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HAFHEPHE_00806 7e-164 xerD D recombinase XerD
HAFHEPHE_00807 1.6e-168 cvfB S S1 domain
HAFHEPHE_00808 3.6e-271 pyk 2.7.1.40, 2.7.7.4 G Belongs to the pyruvate kinase family
HAFHEPHE_00809 0.0 dnaE 2.7.7.7 L DNA polymerase
HAFHEPHE_00810 2.3e-30 S Protein of unknown function (DUF2929)
HAFHEPHE_00811 2.8e-235 pepT 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
HAFHEPHE_00812 2.9e-156 yqfO 3.5.4.16 S Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HAFHEPHE_00813 1.1e-127 trmK 2.1.1.217 S SAM-dependent methyltransferase
HAFHEPHE_00814 1.1e-220 patA 2.6.1.1 E Aminotransferase
HAFHEPHE_00815 4.2e-206 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
HAFHEPHE_00816 0.0 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
HAFHEPHE_00817 0.0 glyS 6.1.1.14 J Glycyl-tRNA synthetase beta subunit
HAFHEPHE_00818 1.7e-179 glyQ 6.1.1.14 J glycyl-tRNA synthetase alpha subunit
HAFHEPHE_00819 3.8e-145 recO L Involved in DNA repair and RecF pathway recombination
HAFHEPHE_00820 5.1e-170 era S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HAFHEPHE_00821 2.1e-59 dgkA 2.7.1.107, 2.7.1.66 M Diacylglycerol kinase
HAFHEPHE_00822 6.1e-82 ybeY 2.6.99.2, 3.5.4.5 S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HAFHEPHE_00823 1.7e-182 phoH T phosphate starvation-inducible protein PhoH
HAFHEPHE_00824 1.2e-172 birA 6.3.4.15 H Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
HAFHEPHE_00825 3.2e-82 bioY S BioY family
HAFHEPHE_00826 4.6e-263 argH 4.3.2.1 E argininosuccinate lyase
HAFHEPHE_00827 3.5e-238 argG 6.3.4.5 E Belongs to the argininosuccinate synthase family. Type 1 subfamily
HAFHEPHE_00828 2.7e-82 cbh 3.5.1.24 M Linear amide C-N hydrolase, choloylglycine hydrolase family protein
HAFHEPHE_00829 6.9e-92 cbh 3.5.1.24 M Linear amide C-N hydrolase, choloylglycine hydrolase family protein
HAFHEPHE_00830 5e-16
HAFHEPHE_00831 1.3e-11 S Transglycosylase associated protein
HAFHEPHE_00832 4.7e-22 S Small integral membrane protein (DUF2273)
HAFHEPHE_00833 1.8e-93
HAFHEPHE_00834 2.3e-99 isp2 L PFAM transposase, IS204 IS1001 IS1096 IS1165 family protein
HAFHEPHE_00835 1.2e-123 L PFAM Transposase, IS204 IS1001 IS1096 IS1165
HAFHEPHE_00836 2.3e-76 traP 1.14.99.57, 6.2.1.3 S enzyme involved in biosynthesis of extracellular polysaccharides
HAFHEPHE_00837 1.2e-65 spxA 1.20.4.1 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
HAFHEPHE_00838 1.2e-120 mecA NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
HAFHEPHE_00839 7.5e-202 coiA 3.6.4.12 S Competence protein
HAFHEPHE_00840 7.3e-183 pipD E Dipeptidase
HAFHEPHE_00841 3.1e-139 L Replication initiation factor
HAFHEPHE_00842 1.7e-25 L Single-strand binding protein family
HAFHEPHE_00843 3.6e-109 L Phage integrase, N-terminal SAM-like domain
HAFHEPHE_00844 3e-98 L Transposase
HAFHEPHE_00847 5.3e-92 snf 2.7.11.1 KL domain protein
HAFHEPHE_00848 0.0 snf 2.7.11.1 KL domain protein
HAFHEPHE_00849 3.5e-143 ywqE 3.1.3.48 GM PHP domain protein
HAFHEPHE_00850 6.6e-178 M Glycosyl hydrolases family 25
HAFHEPHE_00851 1.3e-207 sbcD L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
HAFHEPHE_00852 0.0 sbcC L Putative exonuclease SbcCD, C subunit
HAFHEPHE_00853 3.1e-188 bacI V MacB-like periplasmic core domain
HAFHEPHE_00854 3.7e-128 V ABC transporter
HAFHEPHE_00855 5e-140 bacG M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HAFHEPHE_00856 4.4e-258 gabD 1.2.1.16, 1.2.1.20, 1.2.1.79 C Belongs to the aldehyde dehydrogenase family
HAFHEPHE_00857 1.6e-146 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HAFHEPHE_00858 1.5e-146 E Glyoxalase-like domain
HAFHEPHE_00859 2.1e-224 dhaT 1.1.1.1, 1.1.1.202 C Dehydrogenase
HAFHEPHE_00860 2.2e-96 S reductase
HAFHEPHE_00861 1.9e-23 D CobQ CobB MinD ParA nucleotide binding domain protein
HAFHEPHE_00862 1.3e-25
HAFHEPHE_00863 1.8e-10 K Cro/C1-type HTH DNA-binding domain
HAFHEPHE_00864 1.3e-270 pipD E Dipeptidase
HAFHEPHE_00865 3.8e-310 yjbQ P TrkA C-terminal domain protein
HAFHEPHE_00866 1e-24 dmpI 5.3.2.6 G Belongs to the 4-oxalocrotonate tautomerase family
HAFHEPHE_00867 1.4e-289 glpK 2.7.1.30 F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HAFHEPHE_00868 4.2e-89
HAFHEPHE_00869 3.6e-35
HAFHEPHE_00870 1.7e-99 K DNA-templated transcription, initiation
HAFHEPHE_00871 1e-125
HAFHEPHE_00872 4.8e-64 K Transcriptional regulator, HxlR family
HAFHEPHE_00873 5.2e-163 brpA K Cell envelope-like function transcriptional attenuator common domain protein
HAFHEPHE_00874 8.2e-141 epsB M biosynthesis protein
HAFHEPHE_00875 2.6e-116 ywqD 2.7.10.1 D Capsular exopolysaccharide family
HAFHEPHE_00876 2.1e-53 rfbP M Bacterial sugar transferase
HAFHEPHE_00877 1.8e-37 rfbP M Bacterial sugar transferase
HAFHEPHE_00878 1.1e-16 M Glycosyl transferase 4-like
HAFHEPHE_00879 5.2e-75 M Glycosyl transferases group 1
HAFHEPHE_00880 6.1e-42
HAFHEPHE_00881 2.4e-17 epsH M Hexapeptide repeat of succinyl-transferase
HAFHEPHE_00882 6.1e-44 M Glycosyltransferase like family 2
HAFHEPHE_00883 2.9e-91 rfbX S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
HAFHEPHE_00886 5e-57
HAFHEPHE_00887 1.2e-10 S Protein of unknown function (DUF4044)
HAFHEPHE_00888 1.2e-56 ftsK D Belongs to the FtsK SpoIIIE SftA family
HAFHEPHE_00889 0.0 ftsK D Belongs to the FtsK SpoIIIE SftA family
HAFHEPHE_00890 1.4e-95 trmL 2.1.1.207 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
HAFHEPHE_00891 4.2e-158 rrmA 2.1.1.187 H Methyltransferase
HAFHEPHE_00892 2.8e-180 pgl 3.1.1.31 G Lactonase, 7-bladed beta-propeller
HAFHEPHE_00893 1.7e-14 L Transposase
HAFHEPHE_00894 7.7e-287 L Transposase IS66 family
HAFHEPHE_00895 9.6e-64 XK27_01125 L PFAM IS66 Orf2 family protein
HAFHEPHE_00898 2.8e-13 E Pfam:DUF955
HAFHEPHE_00899 2e-77 2.3.1.128 K Acetyltransferase (GNAT) domain
HAFHEPHE_00900 2.1e-203 lmrB EGP Major facilitator Superfamily
HAFHEPHE_00901 0.0 nrdD 1.1.98.6 F Ribonucleoside-triphosphate reductase
HAFHEPHE_00902 5.8e-111 nrdG 1.97.1.4 O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HAFHEPHE_00903 4.4e-158 sufD O Uncharacterized protein family (UPF0051)
HAFHEPHE_00904 6.1e-42 lytE M LysM domain protein
HAFHEPHE_00905 0.0 oppD EP Psort location Cytoplasmic, score
HAFHEPHE_00906 3.9e-93 lytE M LysM domain protein
HAFHEPHE_00907 7.1e-149 xth 3.1.11.2 L exodeoxyribonuclease III
HAFHEPHE_00908 8.3e-122 preT 1.3.1.1 E Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
HAFHEPHE_00909 2.2e-102 preT 1.3.1.1 E Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
HAFHEPHE_00910 3.8e-235 preA 1.3.1.1 C 4Fe-4S dicluster domain
HAFHEPHE_00911 3.8e-151 yeaE S Aldo keto
HAFHEPHE_00912 3.5e-76 hsp O Belongs to the small heat shock protein (HSP20) family
HAFHEPHE_00913 7.9e-277 dinB 2.7.7.7 L impB/mucB/samB family C-terminal domain
HAFHEPHE_00914 5.5e-65 S Psort location Cytoplasmic, score
HAFHEPHE_00915 2.7e-83 S Short repeat of unknown function (DUF308)
HAFHEPHE_00916 1e-23
HAFHEPHE_00917 4.4e-103 V VanZ like family
HAFHEPHE_00918 9.9e-226 cycA E Amino acid permease
HAFHEPHE_00919 4.3e-85 perR P Belongs to the Fur family
HAFHEPHE_00920 9.6e-256 EGP Major facilitator Superfamily
HAFHEPHE_00921 2.9e-11 S HTH domain
HAFHEPHE_00922 4.4e-80 L Initiator Replication protein
HAFHEPHE_00923 9.6e-09 tnp L Lactococcus lactis RepB C-terminus
HAFHEPHE_00926 6.3e-28 L Phage integrase family
HAFHEPHE_00927 1e-19
HAFHEPHE_00928 2.2e-116 L COG2963 Transposase and inactivated derivatives
HAFHEPHE_00930 8.9e-51 vsr L DNA mismatch endonuclease Vsr
HAFHEPHE_00931 1.3e-40 nlaXM 2.1.1.37 H Cytosine-specific methyltransferase
HAFHEPHE_00932 2.7e-85 S Protein of unknown function (DUF1440)
HAFHEPHE_00933 9.3e-192 fni 1.1.1.88, 5.3.3.2 C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
HAFHEPHE_00934 1.8e-212 mvaK2 2.7.1.36, 2.7.1.43, 2.7.4.2 I phosphomevalonate kinase
HAFHEPHE_00935 2.7e-161 mvaD 4.1.1.33 I diphosphomevalonate decarboxylase
HAFHEPHE_00936 2.4e-170 mvk 1.1.1.88, 2.3.3.10, 2.7.1.36 I mevalonate kinase
HAFHEPHE_00937 0.0 dinG 2.7.7.7, 3.6.4.12 L helicase involved in DNA repair and perhaps also replication
HAFHEPHE_00938 1.3e-85 ypmB S Protein conserved in bacteria
HAFHEPHE_00939 5.2e-122 dnaD L DnaD domain protein
HAFHEPHE_00940 1.4e-162 EG EamA-like transporter family
HAFHEPHE_00941 0.0 ponA 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein 1A
HAFHEPHE_00942 4.4e-117 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
HAFHEPHE_00943 1.3e-99 ypsA S Belongs to the UPF0398 family
HAFHEPHE_00944 1.7e-44 gpsB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
HAFHEPHE_00945 1.1e-24 F Belongs to the NrdI family
HAFHEPHE_00946 2.4e-46 F Belongs to the NrdI family
HAFHEPHE_00947 3.6e-221 rlmL 2.1.1.173, 2.1.1.264 L Belongs to the methyltransferase superfamily
HAFHEPHE_00948 1.8e-71 rnhA 3.1.26.4 L Ribonuclease HI
HAFHEPHE_00949 2.8e-73 lspA 3.4.23.36 MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HAFHEPHE_00950 1.8e-175 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
HAFHEPHE_00951 1.4e-206 carA 6.3.5.5 F Belongs to the CarA family
HAFHEPHE_00952 2.5e-49 carB 6.3.5.5 F Carbamoyl-phosphate synthase
HAFHEPHE_00953 0.0 FbpA K Fibronectin-binding protein
HAFHEPHE_00954 6.6e-159 degV S EDD domain protein, DegV family
HAFHEPHE_00955 1.7e-93
HAFHEPHE_00956 9.5e-118 ypgQ S Metal dependent phosphohydrolases with conserved 'HD' motif.
HAFHEPHE_00957 1.2e-157 gspA M family 8
HAFHEPHE_00958 3.5e-157 S Alpha beta hydrolase
HAFHEPHE_00959 3.4e-94 K Acetyltransferase (GNAT) domain
HAFHEPHE_00960 4.9e-26 C Flavodoxin
HAFHEPHE_00961 1.6e-78 yphH S Cupin domain
HAFHEPHE_00962 2.9e-73 yeaL S UPF0756 membrane protein
HAFHEPHE_00963 2e-242 EGP Major facilitator Superfamily
HAFHEPHE_00964 3.9e-72 copY K Copper transport repressor CopY TcrY
HAFHEPHE_00965 8.5e-246 yhdP S Transporter associated domain
HAFHEPHE_00966 0.0 ubiB S ABC1 family
HAFHEPHE_00967 5.6e-144 S DUF218 domain
HAFHEPHE_00968 8.3e-69 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HAFHEPHE_00969 4.1e-57 crcB D Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HAFHEPHE_00970 0.0 uvrA3 L excinuclease ABC, A subunit
HAFHEPHE_00971 3.4e-81 S SNARE associated Golgi protein
HAFHEPHE_00972 7.7e-164 N Uncharacterized conserved protein (DUF2075)
HAFHEPHE_00973 0.0 dxs 2.2.1.7 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HAFHEPHE_00975 1.1e-84 yifK E Amino acid permease
HAFHEPHE_00976 5.1e-156 endA V DNA/RNA non-specific endonuclease
HAFHEPHE_00977 0.0 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HAFHEPHE_00978 1.3e-70 S Protein of unknown function (DUF3290)
HAFHEPHE_00979 8.1e-114 yviA S Protein of unknown function (DUF421)
HAFHEPHE_00980 2.6e-163 S Alpha/beta hydrolase of unknown function (DUF915)
HAFHEPHE_00981 1.8e-19
HAFHEPHE_00982 1.1e-89 ntd 2.4.2.6 F Nucleoside
HAFHEPHE_00983 1.4e-150 3.1.3.102, 3.1.3.104 S hydrolase
HAFHEPHE_00984 7.6e-42 yrvD S Pfam:DUF1049
HAFHEPHE_00986 1.1e-10 S Phage derived protein Gp49-like (DUF891)
HAFHEPHE_00989 2.3e-164 I alpha/beta hydrolase fold
HAFHEPHE_00990 1.2e-51 glsA 3.5.1.2 E Belongs to the glutaminase family
HAFHEPHE_00991 5.2e-253 dltD M Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HAFHEPHE_00992 8.2e-35 dltC 6.1.1.13 J Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HAFHEPHE_00993 8.7e-234 dltB M MBOAT, membrane-bound O-acyltransferase family
HAFHEPHE_00994 1.6e-293 dltA 6.1.1.13 H Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HAFHEPHE_00996 6.5e-60 acpS 2.7.6.3, 2.7.8.7, 5.1.1.1 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
HAFHEPHE_00997 2.8e-210 alr 5.1.1.1 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HAFHEPHE_00998 3.2e-62 L Toxic component of a toxin-antitoxin (TA) module
HAFHEPHE_00999 4.4e-250 U Belongs to the purine-cytosine permease (2.A.39) family
HAFHEPHE_01000 7.5e-241 codA 3.5.4.1 F cytosine deaminase
HAFHEPHE_01001 5.8e-146 tesE Q hydratase
HAFHEPHE_01005 3.9e-14
HAFHEPHE_01006 5.6e-08 gp17a S Terminase-like family
HAFHEPHE_01007 9e-23 1.1.98.6, 3.6.3.14, 3.6.3.15, 4.1.1.35 L Participates in initiation and elongation during chromosome replication
HAFHEPHE_01008 7.2e-103 L Transposase DDE domain group 1
HAFHEPHE_01009 1.4e-31 L Transposase DDE domain group 1
HAFHEPHE_01010 2.8e-51
HAFHEPHE_01011 8.1e-20
HAFHEPHE_01012 7.1e-92 apt 2.4.2.7 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HAFHEPHE_01013 0.0 recJ L Single-stranded-DNA-specific exonuclease RecJ
HAFHEPHE_01014 7.2e-155 XK27_05435 1.1.1.100 S Belongs to the short-chain dehydrogenases reductases (SDR) family
HAFHEPHE_01015 9.8e-177 rnz 3.1.26.11 J Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
HAFHEPHE_01016 1.5e-247 obg S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HAFHEPHE_01017 0.0 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
HAFHEPHE_01018 7.6e-09
HAFHEPHE_01019 6.1e-60 MA20_27270 S mazG nucleotide pyrophosphohydrolase
HAFHEPHE_01020 1.4e-107 engB D Necessary for normal cell division and for the maintenance of normal septation
HAFHEPHE_01021 1.8e-234 clpX O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HAFHEPHE_01022 3.1e-237 tig D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
HAFHEPHE_01023 3.8e-226 tuf J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HAFHEPHE_01024 3.9e-162 S Tetratricopeptide repeat
HAFHEPHE_01025 0.0 rnjB J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HAFHEPHE_01026 1.6e-42 rpsO J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HAFHEPHE_01027 5.1e-35 rpsT J Binds directly to 16S ribosomal RNA
HAFHEPHE_01028 5.6e-141 holA 2.7.7.7 L DNA polymerase III delta subunit
HAFHEPHE_01029 1.1e-138 comEC S Competence protein ComEC
HAFHEPHE_01030 3.2e-167 comEC S Competence protein ComEC
HAFHEPHE_01031 7.6e-88 comEB 3.5.4.12 F ComE operon protein 2
HAFHEPHE_01032 1.1e-78 comEA L Competence protein ComEA
HAFHEPHE_01033 2.5e-197 ylbL T Belongs to the peptidase S16 family
HAFHEPHE_01034 2.5e-89 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HAFHEPHE_01035 2e-43 ylbG S Uncharacterized protein conserved in bacteria (DUF2129)
HAFHEPHE_01036 2e-222 ftsW D Belongs to the SEDS family
HAFHEPHE_01037 0.0 typA T GTP-binding protein TypA
HAFHEPHE_01038 2.4e-136 suhB 3.1.3.25 G Belongs to the inositol monophosphatase superfamily
HAFHEPHE_01039 1.4e-47 yktA S Belongs to the UPF0223 family
HAFHEPHE_01040 2.7e-274 lpdA 1.8.1.4 C Dehydrogenase
HAFHEPHE_01041 1.3e-222 pdhC 2.3.1.12 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
HAFHEPHE_01042 2.4e-181 pdhB 1.2.4.1 C Transketolase, C-terminal domain protein
HAFHEPHE_01043 8.8e-209 pdhA 1.2.4.1, 1.2.4.4 C Dehydrogenase E1 component
HAFHEPHE_01044 1.3e-102 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
HAFHEPHE_01045 3e-81
HAFHEPHE_01046 9.8e-32 ykzG S Belongs to the UPF0356 family
HAFHEPHE_01047 9.3e-183 ytlR 2.7.1.91 I Diacylglycerol kinase catalytic
HAFHEPHE_01048 5.7e-29
HAFHEPHE_01049 1.1e-137 mltD CBM50 M NlpC P60 family protein
HAFHEPHE_01051 1.2e-55
HAFHEPHE_01052 1e-51 glxK 2.7.1.165 G Belongs to the glycerate kinase type-1 family
HAFHEPHE_01053 1.9e-124 glxK 2.7.1.165 G Belongs to the glycerate kinase type-1 family
HAFHEPHE_01054 2e-197 asd 1.2.1.11 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HAFHEPHE_01055 3.1e-139 dapB 1.17.1.8 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
HAFHEPHE_01056 4.7e-154 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HAFHEPHE_01057 1e-07 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HAFHEPHE_01058 6.5e-223 hipO 3.5.1.47 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
HAFHEPHE_01059 4.8e-75 dapD 2.3.1.117, 2.3.1.89 E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
HAFHEPHE_01060 2.6e-244 lysA 4.1.1.19, 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
HAFHEPHE_01061 4.6e-260 lysC 2.7.2.4 E Belongs to the aspartokinase family
HAFHEPHE_01062 1.3e-171 dapF 5.1.1.7 E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HAFHEPHE_01063 1.5e-29 UW LPXTG-motif cell wall anchor domain protein
HAFHEPHE_01064 3.3e-286 UW LPXTG-motif cell wall anchor domain protein
HAFHEPHE_01065 1.5e-172 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HAFHEPHE_01066 0.0 recD2 3.1.11.5 L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
HAFHEPHE_01067 2.2e-117 S Repeat protein
HAFHEPHE_01068 3.2e-121 pgm6 5.4.2.11, 5.4.2.12 G phosphoglycerate mutase
HAFHEPHE_01069 1.8e-225 mnmA 2.8.1.13 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
HAFHEPHE_01070 7.5e-58 XK27_04120 S Putative amino acid metabolism
HAFHEPHE_01071 1.5e-214 iscS 2.8.1.7 E Aminotransferase class V
HAFHEPHE_01072 8.5e-125 mtnN 3.2.2.9 E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HAFHEPHE_01074 1.1e-98 nudF 3.6.1.13 L ADP-ribose pyrophosphatase
HAFHEPHE_01075 4.7e-31 cspA K Cold shock protein
HAFHEPHE_01076 0.0 ileS 6.1.1.5 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HAFHEPHE_01077 1.9e-42 divIVA D DivIVA domain protein
HAFHEPHE_01078 1.7e-145 ylmH S S4 domain protein
HAFHEPHE_01079 3.2e-40 yggT S YGGT family
HAFHEPHE_01080 9.4e-71 sepF D Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
HAFHEPHE_01081 5.3e-226 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HAFHEPHE_01082 2.1e-252 ftsA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
HAFHEPHE_01083 3e-148 divIB D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
HAFHEPHE_01084 1.5e-203 murG 2.4.1.227, 6.3.2.8 GT28 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HAFHEPHE_01085 4.2e-261 murD 6.3.2.9 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HAFHEPHE_01086 1.7e-179 mraY 2.7.8.13 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HAFHEPHE_01087 0.0 ftsI 3.4.16.4 M Penicillin-binding Protein
HAFHEPHE_01088 1e-55 ftsL D Cell division protein FtsL
HAFHEPHE_01089 1.8e-173 rsmH 2.1.1.199 J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
HAFHEPHE_01090 3.1e-77 mraZ K Belongs to the MraZ family
HAFHEPHE_01109 3.5e-140 L Transposase DDE domain group 1
HAFHEPHE_01110 5.2e-78 lytE M Lysin motif
HAFHEPHE_01111 1e-142 XK27_02985 S Cof-like hydrolase
HAFHEPHE_01112 1e-78 K Transcriptional regulator
HAFHEPHE_01113 0.0 oatA I Acyltransferase
HAFHEPHE_01114 6.9e-50
HAFHEPHE_01115 0.0 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
HAFHEPHE_01116 1.2e-252 glmM 5.4.2.10 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HAFHEPHE_01117 2.9e-125 ybbR S YbbR-like protein
HAFHEPHE_01118 5e-151 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HAFHEPHE_01119 4.8e-249 fucP G Major Facilitator Superfamily
HAFHEPHE_01120 1e-66 rbsD 5.4.99.62 G Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose
HAFHEPHE_01121 2.9e-165 rbsK 2.7.1.15 H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HAFHEPHE_01122 6.1e-168 murB 1.3.1.98 M Cell wall formation
HAFHEPHE_01123 1.7e-101 dnaQ 2.7.7.7 L DNA polymerase III
HAFHEPHE_01124 8.9e-77 S PAS domain
HAFHEPHE_01125 3.9e-29 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
HAFHEPHE_01127 7.1e-41 azlC E azaleucine resistance protein AzlC
HAFHEPHE_01128 8.9e-60 azlC E azaleucine resistance protein AzlC
HAFHEPHE_01129 4.2e-43 azlD E Branched-chain amino acid transport
HAFHEPHE_01130 6.2e-88 S Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)
HAFHEPHE_01132 1.5e-97 S GyrI-like small molecule binding domain
HAFHEPHE_01133 2.7e-123 yhiD S MgtC family
HAFHEPHE_01134 1.3e-93 hpt 2.4.2.8 F Belongs to the purine pyrimidine phosphoribosyltransferase family
HAFHEPHE_01135 1.8e-87 V Beta-lactamase
HAFHEPHE_01136 4.8e-37 V Beta-lactamase
HAFHEPHE_01137 4.1e-36 V Beta-lactamase
HAFHEPHE_01138 8.2e-54 yphI 1.14.99.57 S Antibiotic biosynthesis monooxygenase
HAFHEPHE_01139 7.7e-88 XK27_08850 J Aminoacyl-tRNA editing domain
HAFHEPHE_01140 5.2e-19 relB L Addiction module antitoxin, RelB DinJ family
HAFHEPHE_01141 2.6e-23
HAFHEPHE_01142 2.4e-93 1.1.1.193, 3.5.4.26 H RibD C-terminal domain
HAFHEPHE_01143 1.9e-113 T Transcriptional regulatory protein, C terminal
HAFHEPHE_01144 3.8e-214 T GHKL domain
HAFHEPHE_01145 2.8e-106 S Peptidase propeptide and YPEB domain
HAFHEPHE_01146 1.9e-76 P nitric oxide dioxygenase activity
HAFHEPHE_01147 1.7e-22 P FAD-binding domain
HAFHEPHE_01148 5.8e-09 1.1.1.100 S Enoyl-(Acyl carrier protein) reductase
HAFHEPHE_01149 1e-38 comGC U competence protein ComGC
HAFHEPHE_01150 9.9e-36 NU general secretion pathway protein
HAFHEPHE_01151 4.2e-41
HAFHEPHE_01152 3.4e-71
HAFHEPHE_01154 1.9e-144 ytxK 2.1.1.72 L N-6 DNA Methylase
HAFHEPHE_01155 5.9e-45 L PFAM transposase IS116 IS110 IS902
HAFHEPHE_01156 3.9e-27 L PFAM transposase IS116 IS110 IS902
HAFHEPHE_01157 1.5e-222 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HAFHEPHE_01158 1.7e-113 S Calcineurin-like phosphoesterase
HAFHEPHE_01159 1.7e-93 yutD S Protein of unknown function (DUF1027)
HAFHEPHE_01160 5.2e-131 nagD 2.7.1.25, 3.1.3.41 G Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
HAFHEPHE_01161 1e-103 S Protein of unknown function (DUF1461)
HAFHEPHE_01162 5.5e-110 dedA S SNARE-like domain protein
HAFHEPHE_01163 4.5e-277 hsdR 3.1.21.3 V Subunit R is required for both nuclease and ATPase activities, but not for modification
HAFHEPHE_01164 2.4e-139 IQ reductase
HAFHEPHE_01165 4e-52 yhaI S Protein of unknown function (DUF805)
HAFHEPHE_01166 2.2e-44
HAFHEPHE_01167 1.1e-209 nylA 3.5.1.4 J Belongs to the amidase family
HAFHEPHE_01168 9.3e-47
HAFHEPHE_01169 1.9e-95 K Acetyltransferase (GNAT) domain
HAFHEPHE_01170 1e-295 gntK 2.7.1.12, 2.7.1.17 G Belongs to the FGGY kinase family
HAFHEPHE_01171 2e-40 gntT EG Gluconate
HAFHEPHE_01172 8.5e-24 gntT EG Gluconate
HAFHEPHE_01173 5.6e-133 gntT EG Gluconate
HAFHEPHE_01174 2.1e-180 K Transcriptional regulator, LacI family
HAFHEPHE_01175 8.5e-265 gntK 2.7.1.12, 2.7.1.17 G Belongs to the FGGY kinase family
HAFHEPHE_01176 3.6e-94
HAFHEPHE_01177 2.1e-25
HAFHEPHE_01178 1.1e-62 asp S Asp23 family, cell envelope-related function
HAFHEPHE_01179 3.2e-86 ywnH 2.3.1.183 M Acetyltransferase (GNAT) domain
HAFHEPHE_01181 1.1e-124 rafA 3.2.1.22 G alpha-galactosidase
HAFHEPHE_01182 1.1e-292 rafA 3.2.1.22 G alpha-galactosidase
HAFHEPHE_01183 7.7e-183 galR K Periplasmic binding protein-like domain
HAFHEPHE_01184 3.7e-46
HAFHEPHE_01185 1.3e-87 3.6.4.12 S PD-(D/E)XK nuclease family transposase
HAFHEPHE_01186 1.3e-205 amtB P ammonium transporter
HAFHEPHE_01187 6.4e-246 gor 1.8.1.7 C pyridine nucleotide-disulfide oxidoreductase
HAFHEPHE_01188 2.9e-20 S B3 4 domain
HAFHEPHE_01189 1.1e-90
HAFHEPHE_01190 1.2e-123 pnb C nitroreductase
HAFHEPHE_01191 3.1e-68 XK27_00915 C Luciferase-like monooxygenase
HAFHEPHE_01192 1.6e-55 S Iron-sulphur cluster biosynthesis
HAFHEPHE_01193 5.2e-106 I Carboxylesterase family
HAFHEPHE_01194 9.5e-92 L Helix-turn-helix domain
HAFHEPHE_01195 2.9e-117 hoxN U High-affinity nickel-transport protein
HAFHEPHE_01196 2.6e-132 glpF U Belongs to the MIP aquaporin (TC 1.A.8) family
HAFHEPHE_01197 1.8e-145 larE S NAD synthase
HAFHEPHE_01198 7.3e-228 larC 4.99.1.12 S Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HAFHEPHE_01199 5.1e-131 cpmA S AIR carboxylase
HAFHEPHE_01200 6.4e-235 larA 5.1.2.1 S Domain of unknown function (DUF2088)
HAFHEPHE_01201 7.9e-123 K Crp-like helix-turn-helix domain
HAFHEPHE_01207 6.4e-13 N Bacterial Ig-like domain 2
HAFHEPHE_01208 4e-41 S Calcineurin-like phosphoesterase
HAFHEPHE_01210 1.5e-191 S Peptidase family M23
HAFHEPHE_01211 7e-98 S Phage tail protein
HAFHEPHE_01212 1e-195 D NLP P60 protein
HAFHEPHE_01213 1.9e-79 S Phage tail assembly chaperone protein, TAC
HAFHEPHE_01214 5.3e-105
HAFHEPHE_01215 1.3e-67
HAFHEPHE_01216 2e-84
HAFHEPHE_01217 2.5e-52
HAFHEPHE_01218 1.5e-59 S Phage gp6-like head-tail connector protein
HAFHEPHE_01219 7.3e-200 gpG
HAFHEPHE_01220 2e-78 S Domain of unknown function (DUF4355)
HAFHEPHE_01221 3e-173 S Phage Mu protein F like protein
HAFHEPHE_01222 1.9e-300 S Phage portal protein, SPP1 Gp6-like
HAFHEPHE_01223 1.6e-254 S Phage terminase, large subunit
HAFHEPHE_01224 7.9e-22
HAFHEPHE_01225 3.4e-59 S HicB_like antitoxin of bacterial toxin-antitoxin system
HAFHEPHE_01227 1.6e-56 S Predicted membrane protein (DUF2335)
HAFHEPHE_01229 9.7e-33
HAFHEPHE_01233 1.1e-52 S ORF6C domain
HAFHEPHE_01234 3.2e-52 S Protein of unknown function (DUF1064)
HAFHEPHE_01237 9.2e-57 dnaC 3.4.21.53 L IstB-like ATP binding protein
HAFHEPHE_01238 9.8e-27 ybl78 L DnaD domain protein
HAFHEPHE_01239 8.5e-24 L Psort location Cytoplasmic, score
HAFHEPHE_01240 1.7e-64 S Putative HNHc nuclease
HAFHEPHE_01241 1.5e-42 S Protein of unknown function (DUF669)
HAFHEPHE_01242 1.4e-116 S AAA domain
HAFHEPHE_01243 7.1e-63 S Bacteriophage Mu Gam like protein
HAFHEPHE_01245 6.7e-13 S Domain of unknown function (DUF1508)
HAFHEPHE_01248 9.7e-13 S Domain of unknown function (DUF771)
HAFHEPHE_01249 7.8e-68 S DNA binding
HAFHEPHE_01250 1.5e-13
HAFHEPHE_01251 1.9e-47 ps115 K Helix-turn-helix XRE-family like proteins
HAFHEPHE_01252 2.7e-20 E Zn peptidase
HAFHEPHE_01253 3.3e-18
HAFHEPHE_01254 6.6e-15
HAFHEPHE_01256 6e-132
HAFHEPHE_01258 2.3e-47 L Belongs to the 'phage' integrase family
HAFHEPHE_01259 3.7e-41 L Belongs to the 'phage' integrase family
HAFHEPHE_01261 5.6e-43
HAFHEPHE_01262 4.1e-116 S CAAX protease self-immunity
HAFHEPHE_01263 1.8e-31
HAFHEPHE_01264 6.1e-91 L nuclease
HAFHEPHE_01265 0.0 XK27_00340 3.1.3.5 F Belongs to the 5'-nucleotidase family
HAFHEPHE_01266 5.6e-71
HAFHEPHE_01267 8.2e-102 fic D Fic/DOC family
HAFHEPHE_01268 6.8e-122 nagB 3.1.1.31, 3.5.99.6 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
HAFHEPHE_01269 1e-177
HAFHEPHE_01270 0.0
HAFHEPHE_01271 6e-242
HAFHEPHE_01272 5.6e-84
HAFHEPHE_01273 7.1e-25
HAFHEPHE_01274 7.3e-110 IQ Enoyl-(Acyl carrier protein) reductase
HAFHEPHE_01275 4.2e-154 P CorA-like Mg2+ transporter protein
HAFHEPHE_01276 4.6e-85 L COG2801 Transposase and inactivated derivatives
HAFHEPHE_01277 0.0 trePP 2.4.1.216, 2.4.1.8, 3.1.3.12, 3.2.1.28 GH37,GH65 G Glycosyl hydrolase family 65 central catalytic domain
HAFHEPHE_01278 1.1e-35 pgmB 2.4.1.64, 3.1.3.12, 3.2.1.28, 5.4.2.6 GH37,GH65 S beta-phosphoglucomutase
HAFHEPHE_01279 9.4e-63 pgmB 2.4.1.64, 3.1.3.12, 3.2.1.28, 5.4.2.6 GH37,GH65 S beta-phosphoglucomutase
HAFHEPHE_01280 6.7e-131 S haloacid dehalogenase-like hydrolase
HAFHEPHE_01281 3.4e-82 L Integrase
HAFHEPHE_01282 5.3e-174 3.1.21.3 L N-6 DNA Methylase
HAFHEPHE_01283 2.3e-195 L Transposase and inactivated derivatives, IS30 family
HAFHEPHE_01284 2.8e-87 L PFAM transposase, IS4 family protein
HAFHEPHE_01285 1.1e-152 L PFAM transposase, IS4 family protein
HAFHEPHE_01286 3.9e-195 lplA 6.3.1.20 H Lipoate-protein ligase
HAFHEPHE_01287 7.1e-63
HAFHEPHE_01288 5.2e-14
HAFHEPHE_01289 3.9e-96
HAFHEPHE_01290 5.2e-135 V ABC transporter
HAFHEPHE_01291 1.5e-211 EGP Major facilitator Superfamily
HAFHEPHE_01292 1e-254 G PTS system Galactitol-specific IIC component
HAFHEPHE_01293 7.2e-33 1.6.5.5 C Zinc-binding dehydrogenase
HAFHEPHE_01294 4.4e-33 1.6.5.5 C Zinc-binding dehydrogenase
HAFHEPHE_01295 5e-113 lepB 3.4.21.89 U Belongs to the peptidase S26 family
HAFHEPHE_01296 5.4e-247 yxbA 6.3.1.12 S ATP-grasp enzyme
HAFHEPHE_01297 9.6e-294 murE 6.3.2.13, 6.3.2.7 M Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HAFHEPHE_01298 0.0 asnB 6.3.5.4 E Asparagine synthase
HAFHEPHE_01299 0.0 gidA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
HAFHEPHE_01300 8.1e-252 mnmE S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HAFHEPHE_01301 8.2e-129 jag S R3H domain protein
HAFHEPHE_01302 4.5e-130 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HAFHEPHE_01303 2e-58 rnpA 3.1.26.5 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
HAFHEPHE_01304 3.4e-14 rpmH J Belongs to the bacterial ribosomal protein bL34 family
HAFHEPHE_01305 2.2e-251 dnaA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HAFHEPHE_01306 5.5e-206 dnaN 2.7.7.7 L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
HAFHEPHE_01307 1.1e-86 dps P Ferritin-like domain
HAFHEPHE_01308 1.4e-151 L PFAM Integrase catalytic region
HAFHEPHE_01309 0.0 S SEC-C Motif Domain Protein
HAFHEPHE_01310 1.2e-51
HAFHEPHE_01311 2.6e-141 thiM 2.7.1.50 H Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HAFHEPHE_01312 1.1e-08 thiD 2.5.1.3, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Phosphomethylpyrimidine kinase
HAFHEPHE_01313 1.9e-116 thiD 2.5.1.3, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Phosphomethylpyrimidine kinase
HAFHEPHE_01314 3.9e-116 thiE 2.5.1.3 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
HAFHEPHE_01315 1.1e-228 clcA_2 P Chloride transporter, ClC family
HAFHEPHE_01316 1.3e-101 malZ 3.2.1.20 GH31 G Belongs to the glycosyl hydrolase 31 family
HAFHEPHE_01317 4.9e-111 lssY 3.6.1.27 I Acid phosphatase homologues
HAFHEPHE_01320 6.4e-111 K Transcriptional regulator
HAFHEPHE_01321 3e-34 rplU J This protein binds to 23S rRNA in the presence of protein L20
HAFHEPHE_01322 2.4e-53 ysxB J Cysteine protease Prp
HAFHEPHE_01323 2.1e-45 rpmA J Belongs to the bacterial ribosomal protein bL27 family
HAFHEPHE_01324 1.8e-130 yggS S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HAFHEPHE_01325 1.6e-199 pepP 3.4.11.9, 3.4.13.9 E Creatinase/Prolidase N-terminal domain
HAFHEPHE_01326 9.7e-10 J 2'-5' RNA ligase superfamily
HAFHEPHE_01327 2.4e-90 J 2'-5' RNA ligase superfamily
HAFHEPHE_01328 2.2e-70 yqhY S Asp23 family, cell envelope-related function
HAFHEPHE_01329 1.2e-70 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HAFHEPHE_01330 3.2e-150 folD 1.5.1.5, 3.5.4.9 F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HAFHEPHE_01331 2.5e-234 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HAFHEPHE_01332 9.6e-43 xseB 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HAFHEPHE_01333 2.5e-158 ispA 2.5.1.1, 2.5.1.10, 2.5.1.29, 2.5.1.90 H Belongs to the FPP GGPP synthase family
HAFHEPHE_01334 4.1e-150 rrmJ 2.1.1.226, 2.1.1.227 J Ribosomal RNA large subunit methyltransferase J
HAFHEPHE_01335 1.1e-77 argR K Regulates arginine biosynthesis genes
HAFHEPHE_01336 2e-260 recN L May be involved in recombinational repair of damaged DNA
HAFHEPHE_01337 5.4e-53
HAFHEPHE_01338 4.2e-115 gmk 2.7.4.8 F Essential for recycling GMP and indirectly, cGMP
HAFHEPHE_01339 1e-31 rpoZ 2.7.7.6 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
HAFHEPHE_01340 3.2e-212 coaBC 4.1.1.36, 6.3.2.5 H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HAFHEPHE_01341 0.0 priA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HAFHEPHE_01342 4.8e-171 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HAFHEPHE_01343 8.2e-249 sun 2.1.1.176 J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HAFHEPHE_01344 7.2e-130 stp 3.1.3.16 T phosphatase
HAFHEPHE_01345 0.0 KLT serine threonine protein kinase
HAFHEPHE_01346 9.4e-161 rsgA 3.1.3.100 S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
HAFHEPHE_01347 4.2e-118 rpe 5.1.3.1 G Belongs to the ribulose-phosphate 3-epimerase family
HAFHEPHE_01348 1.4e-121 thiN 2.7.6.2 H thiamine pyrophosphokinase
HAFHEPHE_01349 7e-26 rpmB J Belongs to the bacterial ribosomal protein bL28 family
HAFHEPHE_01350 0.0 yloV S DAK2 domain fusion protein YloV
HAFHEPHE_01351 0.0 recG 3.6.4.12 L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HAFHEPHE_01352 6.8e-187 plsX 2.3.1.15 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
HAFHEPHE_01353 2.9e-38 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
HAFHEPHE_01354 9.5e-132 rnc 3.1.26.3 J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
HAFHEPHE_01355 0.0 smc D Required for chromosome condensation and partitioning
HAFHEPHE_01356 2.5e-177 ftsY U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HAFHEPHE_01357 1.3e-57 ylxM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HAFHEPHE_01358 1.8e-249 ffh 3.6.5.4 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HAFHEPHE_01359 2.2e-44 rpsP J Belongs to the bacterial ribosomal protein bS16 family
HAFHEPHE_01360 4.1e-40 ylqC S Belongs to the UPF0109 family
HAFHEPHE_01361 6.9e-92 rimM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HAFHEPHE_01362 2.9e-142 trmD 2.1.1.228, 4.6.1.12 J Belongs to the RNA methyltransferase TrmD family
HAFHEPHE_01363 1.5e-261 yfnA E amino acid
HAFHEPHE_01364 3.6e-64 rplS J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
HAFHEPHE_01365 7.1e-53 S Mazg nucleotide pyrophosphohydrolase
HAFHEPHE_01366 4.8e-159 xth 3.1.11.2 L exodeoxyribonuclease III
HAFHEPHE_01367 6.5e-45
HAFHEPHE_01368 4.4e-186 lacR K Transcriptional regulator
HAFHEPHE_01369 0.0 lacS G Transporter
HAFHEPHE_01370 2.6e-70 lacZ 3.2.1.23 G -beta-galactosidase
HAFHEPHE_01371 7.3e-77 lacZ 3.2.1.23 G -beta-galactosidase
HAFHEPHE_01372 7.3e-189 lacZ 3.2.1.23 G -beta-galactosidase
HAFHEPHE_01373 3.9e-176 hepT 2.5.1.30, 2.5.1.90 H Belongs to the FPP GGPP synthase family
HAFHEPHE_01374 4.4e-158 menA 2.5.1.74 H 1,4-dihydroxy-2-naphthoate
HAFHEPHE_01375 4.8e-114 frnE Q DSBA-like thioredoxin domain
HAFHEPHE_01376 1.2e-53
HAFHEPHE_01385 2e-127 fabI 1.3.1.10, 1.3.1.9 I Enoyl- acyl-carrier-protein reductase NADH
HAFHEPHE_01386 8.2e-48 accA 2.1.3.15, 6.4.1.2 I alpha subunit
HAFHEPHE_01387 7.9e-141 accD 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HAFHEPHE_01388 4.2e-256 accC 6.3.4.14, 6.4.1.2 I Acetyl-CoA carboxylase biotin carboxylase subunit
HAFHEPHE_01389 3.9e-75 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
HAFHEPHE_01390 5.8e-74 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
HAFHEPHE_01391 9.9e-155 fabF 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
HAFHEPHE_01392 3.4e-48 fabF 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
HAFHEPHE_01393 3.6e-126 IQ reductase
HAFHEPHE_01394 1.5e-159 fabD 2.3.1.39 I Malonyl CoA-acyl carrier protein transacylase
HAFHEPHE_01395 6.5e-35 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
HAFHEPHE_01396 5.8e-172 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HAFHEPHE_01397 4.2e-77 marR K Transcriptional regulator, MarR family
HAFHEPHE_01398 6.6e-72 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
HAFHEPHE_01399 2.4e-167 mccA 2.5.1.134, 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
HAFHEPHE_01400 3.1e-50 S NADPH-dependent FMN reductase
HAFHEPHE_01401 2.5e-21 S NADPH-dependent FMN reductase
HAFHEPHE_01402 4e-179 MA20_14895 S Conserved hypothetical protein 698
HAFHEPHE_01403 1.3e-133 I alpha/beta hydrolase fold
HAFHEPHE_01404 1.5e-156 lsa S ABC transporter
HAFHEPHE_01405 2e-91 lsa S ABC transporter
HAFHEPHE_01406 3e-181 yfeX P Peroxidase
HAFHEPHE_01407 8.2e-274 arcD S C4-dicarboxylate anaerobic carrier
HAFHEPHE_01408 3.9e-259 ytjP 3.5.1.18 E Dipeptidase
HAFHEPHE_01409 2.2e-216 uhpT EGP Major facilitator Superfamily
HAFHEPHE_01410 1.7e-284 gtfA 2.4.1.7 GH13 G Sucrose glucosyltransferase
HAFHEPHE_01411 5e-129 ponA V Beta-lactamase enzyme family
HAFHEPHE_01412 3.6e-219 dacA 3.4.16.4 M Belongs to the peptidase S11 family
HAFHEPHE_01413 6.7e-75
HAFHEPHE_01414 3.7e-201 galM 5.1.3.3 G Catalyzes the interconversion of alpha and beta anomers of maltose
HAFHEPHE_01415 5.8e-22
HAFHEPHE_01418 4.6e-263 S Uncharacterized protein conserved in bacteria (DUF2252)
HAFHEPHE_01419 1.5e-294 L PFAM plasmid pRiA4b ORF-3 family protein
HAFHEPHE_01420 9.6e-205 adhA 1.1.1.1 C Zinc-binding alcohol dehydrogenase family protein
HAFHEPHE_01421 1e-110 ppiB 5.2.1.8 G PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HAFHEPHE_01422 6.5e-154 mleR K LysR family
HAFHEPHE_01423 3.7e-304 sfcA 1.1.1.38, 4.1.1.101 C Malic enzyme
HAFHEPHE_01424 3.8e-257 fumC 4.2.1.2 C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
HAFHEPHE_01425 1.7e-265 frdC 1.3.5.4 C FAD binding domain
HAFHEPHE_01426 3.1e-130 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
HAFHEPHE_01427 1e-164 citP P Sodium:sulfate symporter transmembrane region
HAFHEPHE_01428 4e-125 citR K sugar-binding domain protein
HAFHEPHE_01429 2.5e-177 mez_1 1.1.1.38 C Malic enzyme, NAD binding domain
HAFHEPHE_01430 7e-147 citC 6.2.1.22 H Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HAFHEPHE_01431 8.5e-42 citD C Covalent carrier of the coenzyme of citrate lyase
HAFHEPHE_01432 3.6e-160 citE 4.1.3.25, 4.1.3.34 G Belongs to the HpcH HpaI aldolase family
HAFHEPHE_01433 2.7e-272 citF 2.8.3.10 H Citrate (pro-3S)-lyase alpha chain
HAFHEPHE_01434 1e-153 citG 2.4.2.52, 2.7.7.61 H 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase
HAFHEPHE_01435 9.4e-112 ydjP I Alpha/beta hydrolase family
HAFHEPHE_01436 2.2e-157 mleR K LysR family
HAFHEPHE_01437 5.7e-250 yjjP S Putative threonine/serine exporter
HAFHEPHE_01438 1.8e-116 ung2 3.2.2.27 L Uracil-DNA glycosylase
HAFHEPHE_01439 2.1e-175 emrY EGP Major facilitator Superfamily
HAFHEPHE_01440 6.3e-16 I Alpha beta
HAFHEPHE_01441 9.7e-149 I Alpha beta
HAFHEPHE_01442 5.8e-103 thiJ 2.7.11.1, 3.5.1.124 S DJ-1/PfpI family
HAFHEPHE_01443 0.0 mprF 2.3.2.3 S Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HAFHEPHE_01445 3.3e-158 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 J Responsible for synthesis of pseudouridine from uracil
HAFHEPHE_01446 0.0 trxB2 1.8.1.9 C Thioredoxin domain
HAFHEPHE_01447 7.9e-105 ahpC 1.11.1.15 O Peroxiredoxin
HAFHEPHE_01448 8.8e-143 sdaAA 4.3.1.17 E L-serine dehydratase, iron-sulfur-dependent, alpha subunit
HAFHEPHE_01449 2.9e-122 sdaAB 4.3.1.17 E Serine dehydratase beta chain
HAFHEPHE_01451 7e-43 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HAFHEPHE_01452 3.2e-166 T Calcineurin-like phosphoesterase superfamily domain
HAFHEPHE_01453 2.4e-223 mdtG EGP Major facilitator Superfamily
HAFHEPHE_01454 2.2e-128 menG 2.1.1.163, 2.1.1.201 H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)
HAFHEPHE_01455 9.1e-50 czrA K Transcriptional regulator, ArsR family
HAFHEPHE_01456 1.6e-35
HAFHEPHE_01457 3.3e-273 yhcA V ABC transporter, ATP-binding protein
HAFHEPHE_01458 4.5e-46 yhcA V ABC transporter, ATP-binding protein
HAFHEPHE_01459 3.2e-116 devA 3.6.3.25 V ABC transporter, ATP-binding protein
HAFHEPHE_01460 1.1e-163 hrtB V ABC transporter permease
HAFHEPHE_01461 2e-83 ygfC K transcriptional regulator (TetR family)
HAFHEPHE_01462 2.9e-190 tdh 1.1.1.14 E Alcohol dehydrogenase GroES-like domain
HAFHEPHE_01463 3.7e-285 mntH P H( )-stimulated, divalent metal cation uptake system
HAFHEPHE_01464 1.9e-31
HAFHEPHE_01465 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HAFHEPHE_01467 7e-93 yxiO S Vacuole effluxer Atg22 like
HAFHEPHE_01468 8.9e-30 yxiO S Vacuole effluxer Atg22 like
HAFHEPHE_01469 1.8e-214 npp S type I phosphodiesterase nucleotide pyrophosphatase
HAFHEPHE_01470 7.6e-10 npp S type I phosphodiesterase nucleotide pyrophosphatase
HAFHEPHE_01471 2.9e-241 E amino acid
HAFHEPHE_01472 9.7e-180 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HAFHEPHE_01473 8.9e-309 lmrA 3.6.3.44 V ABC transporter
HAFHEPHE_01474 3.6e-73 K helix_turn_helix multiple antibiotic resistance protein
HAFHEPHE_01476 1.2e-97 K DNA-binding helix-turn-helix protein
HAFHEPHE_01477 1.6e-157 S Polyphosphate nucleotide phosphotransferase, PPK2 family
HAFHEPHE_01478 8.5e-59
HAFHEPHE_01479 3.4e-206 yttB EGP Major facilitator Superfamily
HAFHEPHE_01480 4.3e-29 cspA K Cold shock protein
HAFHEPHE_01481 2.5e-225 L Transposase
HAFHEPHE_01482 2.2e-46 3.2.1.4 GH5,GH9 M domain protein
HAFHEPHE_01484 7.5e-27 4.6.1.1 T Pfam Adenylate and Guanylate cyclase catalytic domain
HAFHEPHE_01486 3.1e-56 tnp2PF3 L Transposase DDE domain
HAFHEPHE_01487 2.3e-53 tnp2PF3 L Putative transposase of IS4/5 family (DUF4096)
HAFHEPHE_01488 1.1e-113 uvrX 2.7.7.7 L Belongs to the DNA polymerase type-Y family
HAFHEPHE_01489 4.2e-97 citG 2.4.2.52, 2.7.7.61 H 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase
HAFHEPHE_01490 2.1e-46 citX 2.4.2.52, 2.7.7.61 HI Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
HAFHEPHE_01491 5.1e-12 citC 6.2.1.22 H Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HAFHEPHE_01492 2e-135 mleP S Membrane transport protein
HAFHEPHE_01493 1.2e-59 mez_1 1.1.1.38 C Malic enzyme, NAD binding domain
HAFHEPHE_01494 4.2e-78 mez_1 1.1.1.38 C Malic enzyme, NAD binding domain
HAFHEPHE_01495 3e-57 K Transcriptional regulator, TetR family
HAFHEPHE_01497 1.7e-93 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HAFHEPHE_01498 1.3e-58
HAFHEPHE_01499 1.4e-253 purA 6.3.4.4 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HAFHEPHE_01500 2.1e-185 guaC 1.1.1.205, 1.7.1.7 F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
HAFHEPHE_01501 6e-260 nox C NADH oxidase
HAFHEPHE_01502 5.3e-86
HAFHEPHE_01504 3.6e-57
HAFHEPHE_01505 1.5e-29 yjcE P Sodium proton antiporter
HAFHEPHE_01507 6.4e-90
HAFHEPHE_01508 0.0 M domain protein
HAFHEPHE_01509 4e-80 M domain protein
HAFHEPHE_01510 6.6e-33
HAFHEPHE_01511 3.7e-177 ampC V Beta-lactamase
HAFHEPHE_01512 4.5e-238 arcA 3.5.3.6 E Arginine
HAFHEPHE_01513 8e-79 argR K Regulates arginine biosynthesis genes
HAFHEPHE_01514 2.2e-260 E Arginine ornithine antiporter
HAFHEPHE_01515 6.1e-223 arcD U Amino acid permease
HAFHEPHE_01516 1.2e-134 cobQ S CobB/CobQ-like glutamine amidotransferase domain
HAFHEPHE_01517 2e-263 murD 3.4.21.10, 6.3.2.13, 6.3.2.9 M Mur ligase, middle domain
HAFHEPHE_01518 6e-108 tdk 2.7.1.21 F thymidine kinase
HAFHEPHE_01519 1.2e-194 prfA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HAFHEPHE_01520 1.5e-163 prmB 2.1.1.297, 2.1.1.298 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
HAFHEPHE_01521 1.5e-194 ywlC 2.7.7.87, 3.1.3.48 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
HAFHEPHE_01522 6e-230 glyA 2.1.2.1 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HAFHEPHE_01523 4.3e-115 upp 2.4.2.9 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HAFHEPHE_01524 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HAFHEPHE_01525 6.6e-188 yibE S overlaps another CDS with the same product name
HAFHEPHE_01526 6.3e-129 yibF S overlaps another CDS with the same product name
HAFHEPHE_01527 2.5e-231 pyrP F Permease
HAFHEPHE_01528 7.3e-124 atpB C it plays a direct role in the translocation of protons across the membrane
HAFHEPHE_01529 1.5e-14 atpE C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HAFHEPHE_01530 1.4e-55 atpF C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HAFHEPHE_01531 4.3e-92 atpH C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HAFHEPHE_01532 6.8e-284 atpA 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HAFHEPHE_01533 1.9e-164 atpG C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HAFHEPHE_01534 1.1e-267 atpD 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HAFHEPHE_01535 2e-68 atpC C Produces ATP from ADP in the presence of a proton gradient across the membrane
HAFHEPHE_01536 1.3e-33 ywzB S Protein of unknown function (DUF1146)
HAFHEPHE_01537 8e-241 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HAFHEPHE_01538 5.5e-178 mbl D Cell shape determining protein MreB Mrl
HAFHEPHE_01539 4.4e-41 yidD S Could be involved in insertion of integral membrane proteins into the membrane
HAFHEPHE_01540 1.1e-30 S Protein of unknown function (DUF2969)
HAFHEPHE_01541 2.4e-220 rodA D Belongs to the SEDS family
HAFHEPHE_01542 2.5e-46 gcvH E glycine cleavage
HAFHEPHE_01543 1.2e-216 ddl 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
HAFHEPHE_01544 1.2e-12
HAFHEPHE_01545 9.1e-73 S Domain of unknown function (DUF4355)
HAFHEPHE_01546 1e-162 gpG
HAFHEPHE_01547 2.9e-101 L Transposase and inactivated derivatives, IS30 family
HAFHEPHE_01548 1.4e-189 yxaB GM Polysaccharide pyruvyl transferase
HAFHEPHE_01549 2.9e-12 L Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
HAFHEPHE_01550 5.8e-291 mco Q Multicopper oxidase
HAFHEPHE_01551 2.2e-240 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HAFHEPHE_01552 4.3e-173
HAFHEPHE_01553 1e-130 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HAFHEPHE_01554 4.1e-242 purD 6.3.4.13 F Belongs to the GARS family
HAFHEPHE_01555 2.6e-291 purH 2.1.2.3, 3.5.4.10 F Bifunctional purine biosynthesis protein PurH
HAFHEPHE_01556 3.1e-104 purN 2.1.2.2 F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HAFHEPHE_01557 4.3e-189 purM 6.3.3.1, 6.3.4.13 F Phosphoribosylformylglycinamidine cyclo-ligase
HAFHEPHE_01558 5e-276 purF 2.4.2.14 F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HAFHEPHE_01559 0.0 purL 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HAFHEPHE_01560 2e-126 purQ 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HAFHEPHE_01561 7e-37 purS 6.3.2.6, 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HAFHEPHE_01562 3.5e-129 purC 4.1.1.21, 4.3.2.2, 6.3.2.6 F Belongs to the SAICAR synthetase family
HAFHEPHE_01563 2e-252 purB 4.3.2.2 F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HAFHEPHE_01564 2.6e-211 purK 6.3.4.18 F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HAFHEPHE_01565 2.5e-83 purE 5.4.99.18 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HAFHEPHE_01566 1.4e-130 budA 4.1.1.5 H Belongs to the alpha-acetolactate decarboxylase family
HAFHEPHE_01567 0.0 alsS 2.2.1.6 EH Belongs to the TPP enzyme family
HAFHEPHE_01568 0.0 fhs 6.3.4.3 F Belongs to the formate--tetrahydrofolate ligase family
HAFHEPHE_01569 1.1e-173 K AI-2E family transporter
HAFHEPHE_01570 7.2e-225 cfa 2.1.1.317, 2.1.1.79 M cyclopropane-fatty-acyl-phospholipid synthase
HAFHEPHE_01571 1.5e-94 ribA 3.5.4.25, 4.1.99.12 H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HAFHEPHE_01572 2.1e-114 thiE 2.5.1.3, 2.7.6.2, 5.4.2.6 S Haloacid dehalogenase-like hydrolase
HAFHEPHE_01573 1.9e-115 pyrE 2.4.2.10, 4.1.1.23 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HAFHEPHE_01574 6e-129 pyrF 4.1.1.23 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
HAFHEPHE_01575 4e-170 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
HAFHEPHE_01576 9.3e-242 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
HAFHEPHE_01577 3.3e-172 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
HAFHEPHE_01578 1.7e-125 K LysR substrate binding domain
HAFHEPHE_01579 6.2e-52 azlD S branched-chain amino acid
HAFHEPHE_01580 3e-138 azlC E AzlC protein
HAFHEPHE_01581 3.2e-201 hpk31 2.7.13.3 T Histidine kinase
HAFHEPHE_01582 3.8e-125 K response regulator
HAFHEPHE_01583 1.6e-208 guaB 1.1.1.205 F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
HAFHEPHE_01584 6.9e-170 deoR K sugar-binding domain protein
HAFHEPHE_01585 5.3e-130 deoD 2.4.2.1, 2.4.2.28 F Purine nucleoside phosphorylase
HAFHEPHE_01586 1.2e-233 pdp 2.4.2.2, 2.4.2.4 F pyrimidine-nucleoside phosphorylase
HAFHEPHE_01587 7e-236 deoB 5.4.2.7 G Phosphotransfer between the C1 and C5 carbon atoms of pentose
HAFHEPHE_01588 5.7e-118 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HAFHEPHE_01589 1.2e-132 XK27_01040 S Protein of unknown function (DUF1129)
HAFHEPHE_01590 2e-200 ychF J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
HAFHEPHE_01591 5.4e-32 yyzM S Bacterial protein of unknown function (DUF951)
HAFHEPHE_01592 4.2e-153 spo0J K Belongs to the ParB family
HAFHEPHE_01593 3.9e-139 soj D Sporulation initiation inhibitor
HAFHEPHE_01594 2.7e-145 noc K Belongs to the ParB family
HAFHEPHE_01595 1.5e-124 rsmG 2.1.1.170 J Specifically methylates the N7 position of a guanine in 16S rRNA
HAFHEPHE_01596 7.7e-163 fadB4 1.1.1.157 I 3-hydroxyacyl-CoA dehydrogenase
HAFHEPHE_01597 6e-171 rihC 3.2.2.1 F Nucleoside
HAFHEPHE_01598 6.7e-218 nupG F Nucleoside transporter
HAFHEPHE_01599 6.5e-222 cycA E Amino acid permease
HAFHEPHE_01600 3.6e-129 yebC K Transcriptional regulatory protein
HAFHEPHE_01601 1.6e-130
HAFHEPHE_01602 2.7e-180 ccpA K catabolite control protein A
HAFHEPHE_01603 4.4e-208 pepQ 3.4.13.9 E Creatinase/Prolidase N-terminal domain
HAFHEPHE_01604 4.6e-26
HAFHEPHE_01605 1e-35 WQ51_05790 S protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HAFHEPHE_01606 8.4e-146 ykuT M mechanosensitive ion channel
HAFHEPHE_01607 4.4e-152 3.1.3.102, 3.1.3.104, 3.1.3.23 S haloacid dehalogenase-like hydrolase
HAFHEPHE_01608 1.1e-74 ykuL S (CBS) domain
HAFHEPHE_01609 3.2e-92 S Phosphoesterase
HAFHEPHE_01610 3.6e-100 rdgB 3.6.1.66, 5.1.1.3 F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HAFHEPHE_01611 4.6e-107 murI 3.6.1.66, 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
HAFHEPHE_01612 4.6e-97 yslB S Protein of unknown function (DUF2507)
HAFHEPHE_01613 1.4e-53 trxA O Belongs to the thioredoxin family
HAFHEPHE_01614 0.0 mutS2 L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
HAFHEPHE_01615 1.7e-85 cvpA S Colicin V production protein
HAFHEPHE_01616 2.3e-47 yrzB S Belongs to the UPF0473 family
HAFHEPHE_01617 4.7e-76 yqgF J Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HAFHEPHE_01618 1.6e-42 yrzL S Belongs to the UPF0297 family
HAFHEPHE_01619 0.0 alaS 6.1.1.7 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HAFHEPHE_01620 1.4e-232 cshB 3.6.4.13 JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
HAFHEPHE_01621 4.2e-183 nrnA 3.1.13.3, 3.1.3.7 S DHHA1 domain protein
HAFHEPHE_01622 1.4e-30 yajC U Preprotein translocase
HAFHEPHE_01623 3.6e-186 tgt_1 2.4.2.29 F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
HAFHEPHE_01624 1e-190 ruvB 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
HAFHEPHE_01625 4.3e-101 ruvA 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
HAFHEPHE_01626 0.0 mutL L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HAFHEPHE_01627 0.0 mutS L that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HAFHEPHE_01628 1.4e-207 rny S Endoribonuclease that initiates mRNA decay
HAFHEPHE_01629 2.9e-196 recA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HAFHEPHE_01630 6.9e-226 cinA 3.5.1.42 S Belongs to the CinA family
HAFHEPHE_01631 3.2e-101 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HAFHEPHE_01632 2.3e-142 ymfM S Helix-turn-helix domain
HAFHEPHE_01633 9.2e-179 ymfH S Peptidase M16
HAFHEPHE_01634 1.1e-228 ymfF S Peptidase M16 inactive domain protein
HAFHEPHE_01635 1e-159 aatB ET ABC transporter substrate-binding protein
HAFHEPHE_01636 2.1e-117 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
HAFHEPHE_01637 1.2e-101 glnP P ABC transporter permease
HAFHEPHE_01638 8.7e-93 mreD M rod shape-determining protein MreD
HAFHEPHE_01639 3.8e-151 mreC M Involved in formation and maintenance of cell shape
HAFHEPHE_01640 5.1e-179 mreB D cell shape determining protein MreB
HAFHEPHE_01641 1.5e-120 radC L DNA repair protein
HAFHEPHE_01642 4.7e-241 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
HAFHEPHE_01643 3.8e-229 ndh 1.6.99.3 C NADH dehydrogenase
HAFHEPHE_01644 0.0 cydD CO ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HAFHEPHE_01645 2e-308 cydD CO ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydD
HAFHEPHE_01646 2e-183 cydB 1.10.3.14 C Cytochrome d ubiquinol oxidase subunit II
HAFHEPHE_01647 1.2e-271 cydA 1.10.3.14 C ubiquinol oxidase
HAFHEPHE_01648 0.0 valS 6.1.1.9 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
HAFHEPHE_01649 5.5e-228 thiI 2.8.1.4 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HAFHEPHE_01650 7.3e-214 iscS2 2.8.1.7 E Aminotransferase class V
HAFHEPHE_01651 6.5e-251 ezrA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HAFHEPHE_01652 3.7e-108 rpsD J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HAFHEPHE_01653 3.6e-39
HAFHEPHE_01654 1.6e-285 lacS G Transporter
HAFHEPHE_01655 1.6e-128 ltrA S Bacterial low temperature requirement A protein (LtrA)
HAFHEPHE_01656 3.3e-80 uspA T universal stress protein
HAFHEPHE_01657 5.6e-80 K AsnC family
HAFHEPHE_01658 4.4e-231 gltP U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
HAFHEPHE_01659 1.9e-96 dedA 3.1.3.1 S SNARE associated Golgi protein
HAFHEPHE_01660 3.8e-179 galR K Transcriptional regulator
HAFHEPHE_01661 2.5e-280 galT 2.7.7.12 G UDP-glucose--hexose-1-phosphate uridylyltransferase
HAFHEPHE_01662 9.4e-225 galK 2.7.1.6 F Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HAFHEPHE_01663 8.4e-179 celE 3.2.1.4 GH5,GH9 E GDSL-like Lipase/Acylhydrolase family
HAFHEPHE_01664 1.3e-145 ptp3 3.1.3.48 T Tyrosine phosphatase family
HAFHEPHE_01665 1.1e-92 yxkA S Phosphatidylethanolamine-binding protein
HAFHEPHE_01666 2.6e-35
HAFHEPHE_01667 2.8e-37
HAFHEPHE_01668 2.9e-265 S Putative peptidoglycan binding domain
HAFHEPHE_01670 1.5e-11 2.7.13.3 T GHKL domain
HAFHEPHE_01671 9.9e-117 2.7.13.3 T GHKL domain
HAFHEPHE_01672 8.3e-104 K LytTr DNA-binding domain
HAFHEPHE_01673 4.2e-74 osmC O OsmC-like protein
HAFHEPHE_01674 2e-175 ldhD 1.1.1.28 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HAFHEPHE_01675 3.1e-215 patA 2.6.1.1 E Aminotransferase
HAFHEPHE_01676 7.8e-32
HAFHEPHE_01677 0.0 clpL O associated with various cellular activities
HAFHEPHE_01678 1.8e-206 menC 4.2.1.113 H Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)
HAFHEPHE_01680 1.1e-116 yrkL S Flavodoxin-like fold
HAFHEPHE_01681 3.6e-54
HAFHEPHE_01682 8.7e-19 S Domain of unknown function (DUF4767)
HAFHEPHE_01683 1.4e-29 3.6.4.12 S PD-(D/E)XK nuclease family transposase
HAFHEPHE_01684 1.1e-49
HAFHEPHE_01686 9.2e-203 nrnB S DHHA1 domain
HAFHEPHE_01687 3e-229 S Uncharacterized protein conserved in bacteria (DUF2325)
HAFHEPHE_01688 1.2e-247 brnQ U Component of the transport system for branched-chain amino acids
HAFHEPHE_01689 8.3e-105 NU mannosyl-glycoprotein
HAFHEPHE_01690 1.8e-139 S Putative ABC-transporter type IV
HAFHEPHE_01691 2.7e-272 S ABC transporter, ATP-binding protein
HAFHEPHE_01692 1.3e-73 M PFAM NLP P60 protein
HAFHEPHE_01693 2.4e-181 ABC-SBP S ABC transporter
HAFHEPHE_01694 1.1e-153 XK27_08840 U Belongs to the binding-protein-dependent transport system permease family
HAFHEPHE_01695 3.2e-133 XK27_08845 S ABC transporter, ATP-binding protein
HAFHEPHE_01696 2.9e-91 P Cadmium resistance transporter
HAFHEPHE_01697 6.8e-56 K Transcriptional regulator, ArsR family
HAFHEPHE_01698 2.7e-236 mepA V MATE efflux family protein
HAFHEPHE_01699 2.7e-54 trxA O Belongs to the thioredoxin family
HAFHEPHE_01700 3e-131 terC P membrane
HAFHEPHE_01701 9.7e-169 rluA 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
HAFHEPHE_01702 6.5e-165 corA P CorA-like Mg2+ transporter protein
HAFHEPHE_01703 2e-97 pipD E Dipeptidase
HAFHEPHE_01704 2.5e-155 pipD E Dipeptidase
HAFHEPHE_01705 1.6e-241 pbuX F xanthine permease
HAFHEPHE_01706 8.5e-249 nhaC C Na H antiporter NhaC
HAFHEPHE_01707 1.4e-284 S C4-dicarboxylate anaerobic carrier
HAFHEPHE_01708 1.9e-126 pgm3 3.1.3.73 G phosphoglycerate mutase family
HAFHEPHE_01709 3.8e-41
HAFHEPHE_01710 0.0 ltaS 2.7.8.20 M Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
HAFHEPHE_01711 1.9e-206 gldA 1.1.1.6 C dehydrogenase
HAFHEPHE_01712 6.8e-124 S Alpha beta hydrolase
HAFHEPHE_01713 7.6e-94 dacA 3.4.16.4 M Belongs to the peptidase S11 family
HAFHEPHE_01714 2.1e-112 dacA 3.4.16.4 M Belongs to the peptidase S11 family
HAFHEPHE_01715 7.2e-101
HAFHEPHE_01717 2e-123 yciB M ErfK YbiS YcfS YnhG
HAFHEPHE_01718 1.6e-64 ydiI Q Thioesterase superfamily
HAFHEPHE_01719 1.6e-154 menB 4.1.3.36 H Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HAFHEPHE_01720 1.7e-268 menE 6.2.1.26 H Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily
HAFHEPHE_01721 0.0 feoB P transporter of a GTP-driven Fe(2 ) uptake system
HAFHEPHE_01722 9.6e-32 feoA P FeoA domain
HAFHEPHE_01723 6.5e-145 sufC O FeS assembly ATPase SufC
HAFHEPHE_01724 5.8e-236 sufD O FeS assembly protein SufD
HAFHEPHE_01725 4.1e-231 sufS 2.8.1.7, 4.4.1.16 E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HAFHEPHE_01726 6.5e-81 nifU C SUF system FeS assembly protein, NifU family
HAFHEPHE_01727 1.8e-270 sufB O assembly protein SufB
HAFHEPHE_01728 2.8e-57 yitW S Iron-sulfur cluster assembly protein
HAFHEPHE_01729 4.8e-157 hipB K Helix-turn-helix
HAFHEPHE_01730 2e-112 nreC K PFAM regulatory protein LuxR
HAFHEPHE_01731 9.2e-39 S Cytochrome B5
HAFHEPHE_01732 8.6e-153 yitU 3.1.3.104 S hydrolase
HAFHEPHE_01733 2.2e-262 rsmF 2.1.1.176, 2.1.1.178 J NOL1 NOP2 sun family protein
HAFHEPHE_01734 6.8e-148 f42a O Band 7 protein
HAFHEPHE_01735 0.0 lytS 2.7.13.3 T LytS YhcK-type transmembrane receptor domain protein
HAFHEPHE_01736 4e-125 lytT K response regulator receiver
HAFHEPHE_01737 1.9e-66 lrgA S LrgA family
HAFHEPHE_01738 1.7e-123 lrgB M LrgB-like family
HAFHEPHE_01739 3.9e-176 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
HAFHEPHE_01740 2.4e-169 scrK 2.7.1.2, 2.7.1.4 GK ROK family
HAFHEPHE_01741 2.5e-33
HAFHEPHE_01742 4.4e-48 S Bacteriophage holin of superfamily 6 (Holin_LLH)
HAFHEPHE_01743 1.9e-180 M Glycosyl hydrolases family 25
HAFHEPHE_01744 4.4e-240 bcgIA 2.1.1.72 V Type I restriction-modification system methyltransferase subunit()
HAFHEPHE_01745 6.9e-129 3.1.21.3 V Type I restriction modification DNA specificity domain
HAFHEPHE_01746 2.4e-68
HAFHEPHE_01747 5.3e-56 folB 1.13.11.81, 2.5.1.15, 2.7.6.3, 4.1.2.25, 5.1.99.8 H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HAFHEPHE_01748 4.1e-92 folK 1.13.11.81, 2.5.1.15, 2.7.6.3, 3.5.4.16, 4.1.2.25, 5.1.99.8 H 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)
HAFHEPHE_01749 6.9e-104 folE 2.7.6.3, 3.5.4.16 F GTP cyclohydrolase 1
HAFHEPHE_01750 4.7e-222 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
HAFHEPHE_01751 7.2e-101 xtp 2.5.1.15, 3.6.1.66 F Ham1 family
HAFHEPHE_01752 2.4e-209 folP 2.5.1.15 H dihydropteroate synthase
HAFHEPHE_01753 5.1e-43
HAFHEPHE_01754 5.1e-31
HAFHEPHE_01756 6.5e-51
HAFHEPHE_01757 4.8e-202
HAFHEPHE_01758 1.7e-82 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
HAFHEPHE_01759 5.2e-136 pnuC H nicotinamide mononucleotide transporter
HAFHEPHE_01760 3.8e-24 ytbE 1.1.1.346 S Aldo keto reductase
HAFHEPHE_01762 2.2e-191 ysaB V FtsX-like permease family
HAFHEPHE_01763 4.5e-157 metAA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to
HAFHEPHE_01764 6.3e-168 cysK 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
HAFHEPHE_01765 6e-285 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HAFHEPHE_01766 5.2e-61 EGP Major facilitator Superfamily
HAFHEPHE_01767 1.2e-80 EGP Major facilitator Superfamily
HAFHEPHE_01768 1.7e-25 EGP Major facilitator Superfamily
HAFHEPHE_01769 8.7e-87 ymdB S Macro domain protein
HAFHEPHE_01770 2.7e-109 K Helix-turn-helix domain
HAFHEPHE_01771 0.0 pepO 3.4.24.71 O Peptidase family M13
HAFHEPHE_01772 3.6e-48
HAFHEPHE_01773 7.9e-233 S Putative metallopeptidase domain
HAFHEPHE_01774 2.2e-202 3.1.3.1 S associated with various cellular activities
HAFHEPHE_01775 2.2e-119 mpg 3.2.2.21 L Belongs to the DNA glycosylase MPG family
HAFHEPHE_01776 5.8e-64 yeaO S Protein of unknown function, DUF488
HAFHEPHE_01777 1.8e-95 yqeG S HAD phosphatase, family IIIA
HAFHEPHE_01778 2.1e-218 yqeH S Ribosome biogenesis GTPase YqeH
HAFHEPHE_01779 5.4e-47 yhbY J RNA-binding protein
HAFHEPHE_01780 7.6e-120 nadD 2.7.7.18, 3.6.1.55 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HAFHEPHE_01781 2.3e-110 nadD 2.7.6.3, 2.7.7.18 H Hydrolase, HD family
HAFHEPHE_01782 4.9e-60 rsfS J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
HAFHEPHE_01783 5.1e-136 yqeM Q Methyltransferase
HAFHEPHE_01784 3.4e-208 ylbM S Belongs to the UPF0348 family
HAFHEPHE_01785 5.4e-98 yceD S Uncharacterized ACR, COG1399
HAFHEPHE_01786 1.1e-28 rpmF J Belongs to the bacterial ribosomal protein bL32 family
HAFHEPHE_01787 1.5e-121 K response regulator
HAFHEPHE_01788 3.7e-279 arlS 2.7.13.3 T Histidine kinase
HAFHEPHE_01789 3.2e-62 yjeM E Amino Acid
HAFHEPHE_01790 2.2e-182 yjeM E Amino Acid
HAFHEPHE_01791 6.4e-230 V MatE
HAFHEPHE_01792 1e-69 def_1 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins
HAFHEPHE_01793 5.9e-169 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HAFHEPHE_01794 1.6e-42 acyP 3.6.1.7 C Belongs to the acylphosphatase family
HAFHEPHE_01795 8.3e-145 spoU 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HAFHEPHE_01796 5.3e-92 XK27_09705 6.1.1.14 S Metal dependent phosphohydrolases with conserved 'HD' motif.
HAFHEPHE_01797 6.7e-59 yodB K Transcriptional regulator, HxlR family
HAFHEPHE_01798 1.5e-197 pheS 6.1.1.20 J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HAFHEPHE_01799 0.0 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HAFHEPHE_01800 4.7e-114 rlpA M PFAM NLP P60 protein
HAFHEPHE_01801 3.1e-116 udk 2.7.1.48 F Cytidine monophosphokinase
HAFHEPHE_01802 5.3e-78 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
HAFHEPHE_01803 3.1e-68 yneR S Belongs to the HesB IscA family
HAFHEPHE_01804 0.0 S membrane
HAFHEPHE_01805 0.0 pbp2b 3.4.16.4 M Penicillin-binding Protein
HAFHEPHE_01806 4.2e-21 rpmG J Belongs to the bacterial ribosomal protein bL33 family
HAFHEPHE_01807 4.9e-99 ygfA 6.3.3.2 H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HAFHEPHE_01808 8.4e-106 gluP 3.4.21.105 S Peptidase, S54 family
HAFHEPHE_01809 7.4e-36 yqgQ S Bacterial protein of unknown function (DUF910)
HAFHEPHE_01810 1.5e-183 glk 2.7.1.2 G Glucokinase
HAFHEPHE_01811 1.3e-66 yqhL P Rhodanese-like protein
HAFHEPHE_01812 5.9e-22 S Protein of unknown function (DUF3042)
HAFHEPHE_01813 1.2e-174 miaA 2.5.1.75 F Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HAFHEPHE_01814 2.2e-262 glnA 6.3.1.2 E glutamine synthetase
HAFHEPHE_01815 2.2e-295 gltX 6.1.1.17, 6.1.1.24 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HAFHEPHE_01816 0.0 csd1 3.5.1.28 G domain, Protein
HAFHEPHE_01817 2.2e-162 yueF S AI-2E family transporter
HAFHEPHE_01818 1.2e-213 brpA K Cell envelope-like function transcriptional attenuator common domain protein
HAFHEPHE_01819 1.7e-309 prfC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HAFHEPHE_01820 2.5e-12 M NlpC/P60 family
HAFHEPHE_01821 0.0 M NlpC/P60 family
HAFHEPHE_01822 4.9e-249 S Peptidase, M23
HAFHEPHE_01823 6e-255 S Peptidase, M23
HAFHEPHE_01824 1e-63 gntR1 K Transcriptional regulator, GntR family
HAFHEPHE_01825 9.5e-158 V ABC transporter, ATP-binding protein
HAFHEPHE_01826 1.6e-115
HAFHEPHE_01827 8e-142 manA 1.14.13.81, 5.3.1.8, 5.4.2.8 G MucBP domain
HAFHEPHE_01828 4.9e-100 S Pfam:DUF3816
HAFHEPHE_01829 0.0 clpE O Belongs to the ClpA ClpB family
HAFHEPHE_01830 8.3e-27
HAFHEPHE_01831 2.7e-39 ptsH G phosphocarrier protein HPR
HAFHEPHE_01832 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HAFHEPHE_01833 2.7e-227 mgs 2.4.1.337 GT4 M Glycosyltransferase, group 1 family protein
HAFHEPHE_01834 1.5e-197 cpoA GT4 M Glycosyltransferase, group 1 family protein
HAFHEPHE_01835 3.3e-178 mprF I Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HAFHEPHE_01836 1.5e-39 ykuJ S Protein of unknown function (DUF1797)
HAFHEPHE_01837 7.7e-48
HAFHEPHE_01839 3.2e-38 mscL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
HAFHEPHE_01840 2.4e-56 K transcriptional regulator PadR family
HAFHEPHE_01841 2.5e-80 XK27_06920 S Protein of unknown function (DUF1700)
HAFHEPHE_01842 5.4e-133 S Putative adhesin
HAFHEPHE_01843 0.0 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
HAFHEPHE_01844 2.2e-198 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HAFHEPHE_01845 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HAFHEPHE_01846 3.4e-35 nrdH O Glutaredoxin
HAFHEPHE_01847 3.8e-90 tadA 3.5.4.33 F Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
HAFHEPHE_01848 6.4e-281 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HAFHEPHE_01849 7.8e-46 yaaK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HAFHEPHE_01850 3.3e-109 recR L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HAFHEPHE_01851 9.7e-39 S Protein of unknown function (DUF2508)
HAFHEPHE_01852 9.6e-115 tmk 2.7.4.9 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HAFHEPHE_01853 7.6e-52 yaaQ S Cyclic-di-AMP receptor
HAFHEPHE_01854 5.5e-181 holB 2.7.7.7 L DNA polymerase III
HAFHEPHE_01855 5.9e-58 yabA L Involved in initiation control of chromosome replication
HAFHEPHE_01856 1e-156 rsmI 2.1.1.198 H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HAFHEPHE_01857 3.2e-133 fat 3.1.2.21 I Acyl-ACP thioesterase
HAFHEPHE_01858 9.7e-283 ppx3 3.6.1.11, 3.6.1.40 FP exopolyphosphatase
HAFHEPHE_01859 0.0 ppk 2.7.4.1 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HAFHEPHE_01860 1.9e-170 ppx 3.6.1.11, 3.6.1.40 FP exopolyphosphatase
HAFHEPHE_01861 5.7e-191 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
HAFHEPHE_01862 2.6e-124 yeaZ 2.3.1.234 O Universal bacterial protein YeaZ
HAFHEPHE_01863 4.7e-102 rimI 2.3.1.128 K Ribosomal-protein-alanine acetyltransferase
HAFHEPHE_01864 8.9e-195 tsaD 2.3.1.234 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HAFHEPHE_01865 4e-131 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HAFHEPHE_01866 3.8e-216 proA 1.2.1.41 E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HAFHEPHE_01867 4.2e-136 proB 2.7.2.11 F Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HAFHEPHE_01868 3.1e-139 mtnU 3.5.1.3 S Carbon-nitrogen hydrolase
HAFHEPHE_01869 1.2e-224 mtnE 2.6.1.83 E Aminotransferase
HAFHEPHE_01870 1.5e-183 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HAFHEPHE_01871 7e-310 uup S ABC transporter, ATP-binding protein
HAFHEPHE_01872 8.2e-114 rex K Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HAFHEPHE_01873 3.3e-43 groS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HAFHEPHE_01874 1.4e-290 groL O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
HAFHEPHE_01875 2.4e-81 S Aminoacyl-tRNA editing domain
HAFHEPHE_01876 2.4e-303 ybeC E amino acid
HAFHEPHE_01877 0.0 ydaO E amino acid
HAFHEPHE_01878 1.6e-39
HAFHEPHE_01879 1.8e-66 rmaI K Transcriptional regulator
HAFHEPHE_01880 4.2e-182 EGP Major facilitator Superfamily
HAFHEPHE_01881 8.1e-36 EGP Major facilitator Superfamily
HAFHEPHE_01882 2e-109 yvyE 3.4.13.9 S YigZ family
HAFHEPHE_01883 2.2e-254 comFA L Helicase C-terminal domain protein
HAFHEPHE_01884 7.2e-113 comFC S Competence protein
HAFHEPHE_01885 6.8e-93 hpf J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HAFHEPHE_01886 0.0 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
HAFHEPHE_01887 4.3e-186 prfB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HAFHEPHE_01888 3.5e-31 KT PspC domain protein
HAFHEPHE_01889 1.7e-52 yvlD S Mycobacterial 4 TMS phage holin, superfamily IV
HAFHEPHE_01890 3.9e-176 hprK F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HAFHEPHE_01891 9.1e-158 lgt 2.1.1.199 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HAFHEPHE_01892 1.2e-183 gpsA 1.1.1.94 I Glycerol-3-phosphate dehydrogenase
HAFHEPHE_01893 1.1e-169 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
HAFHEPHE_01894 3.6e-134 yrjD S LUD domain
HAFHEPHE_01895 2.4e-286 lutB C 4Fe-4S dicluster domain
HAFHEPHE_01896 5.2e-158 lutA C Cysteine-rich domain
HAFHEPHE_01897 8.6e-173 trxB 1.8.1.9 C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
HAFHEPHE_01898 4.1e-212 argE 3.5.1.18 E succinyl-diaminopimelate desuccinylase
HAFHEPHE_01899 5.5e-161 aatB ET PFAM extracellular solute-binding protein, family 3
HAFHEPHE_01900 1.1e-86 ykhA 3.1.2.20 I Thioesterase superfamily
HAFHEPHE_01901 0.0 pgm 5.4.2.2, 5.4.2.8 G Phosphoglucomutase phosphomannomutase, alpha beta alpha domain
HAFHEPHE_01902 2.5e-115 yfbR S HD containing hydrolase-like enzyme
HAFHEPHE_01903 1.5e-13
HAFHEPHE_01904 0.0 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
HAFHEPHE_01905 0.0 uvrA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
HAFHEPHE_01906 2.7e-244 steT E amino acid
HAFHEPHE_01907 1e-159 rapZ S Displays ATPase and GTPase activities
HAFHEPHE_01908 3.8e-182 ybhK S Required for morphogenesis under gluconeogenic growth conditions
HAFHEPHE_01909 3.4e-169 whiA K May be required for sporulation
HAFHEPHE_01911 1.5e-14
HAFHEPHE_01912 9.1e-240 glpT G Major Facilitator Superfamily
HAFHEPHE_01913 2.1e-103 clpP 3.4.21.92 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
HAFHEPHE_01915 1.1e-189 gap 1.2.1.12 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
HAFHEPHE_01916 2.4e-228 pgk 2.7.2.3, 5.3.1.1 F Belongs to the phosphoglycerate kinase family
HAFHEPHE_01917 4.8e-142 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
HAFHEPHE_01918 4.2e-250 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
HAFHEPHE_01919 7.6e-116 S Domain of unknown function (DUF4811)
HAFHEPHE_01920 6.1e-253 lmrB EGP Major facilitator Superfamily
HAFHEPHE_01921 1.3e-73 merR K MerR HTH family regulatory protein
HAFHEPHE_01922 3.3e-53
HAFHEPHE_01923 0.0 rnjA J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HAFHEPHE_01924 2.3e-215 S CAAX protease self-immunity
HAFHEPHE_01925 4e-108 glnP P ABC transporter permease
HAFHEPHE_01926 3.2e-110 gluC P ABC transporter permease
HAFHEPHE_01927 3.7e-151 glnH ET ABC transporter
HAFHEPHE_01928 5.3e-133 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
HAFHEPHE_01929 1.8e-81 usp1 T Belongs to the universal stress protein A family
HAFHEPHE_01930 1.1e-108 S VIT family
HAFHEPHE_01931 3e-114 S membrane
HAFHEPHE_01932 3.2e-164 czcD P cation diffusion facilitator family transporter
HAFHEPHE_01933 9.1e-124 sirR K iron dependent repressor
HAFHEPHE_01934 1.9e-29 cspC K Cold shock protein
HAFHEPHE_01935 7.6e-127 thrE S Putative threonine/serine exporter
HAFHEPHE_01936 2.5e-80 S Threonine/Serine exporter, ThrE
HAFHEPHE_01937 8.8e-119 lssY 3.6.1.27 I phosphatase
HAFHEPHE_01938 3.5e-10 2.3.1.128 J Acetyltransferase (GNAT) domain
HAFHEPHE_01939 2.3e-276 lysP E amino acid
HAFHEPHE_01940 4.8e-114 dak 2.7.1.74, 2.7.1.76 F deoxynucleoside kinase
HAFHEPHE_01946 2e-103 S Hydrolases of the alpha beta superfamily
HAFHEPHE_01947 5.3e-66 S Hydrolases of the alpha beta superfamily
HAFHEPHE_01948 2.1e-196 adhP 1.1.1.1 C alcohol dehydrogenase
HAFHEPHE_01949 3.4e-77 ctsR K Belongs to the CtsR family
HAFHEPHE_01950 0.0 clpC O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
HAFHEPHE_01951 1.8e-110 K Bacterial regulatory proteins, tetR family
HAFHEPHE_01952 0.0 rpoB 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HAFHEPHE_01953 0.0 rpoC 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HAFHEPHE_01954 1e-199 ykiI
HAFHEPHE_01955 8.8e-83 S Bacterial membrane protein, YfhO
HAFHEPHE_01956 3.9e-25
HAFHEPHE_01957 8.2e-89 S Glycosyltransferase like family
HAFHEPHE_01958 1e-86 M Domain of unknown function (DUF4422)
HAFHEPHE_01959 4.1e-41 M biosynthesis protein
HAFHEPHE_01960 5e-93 cps3F
HAFHEPHE_01961 3.2e-103 M Glycosyltransferase like family 2
HAFHEPHE_01962 2.6e-111 S Glycosyltransferase like family 2
HAFHEPHE_01963 1.1e-74 rgpB GT2 M Glycosyl transferase family 2
HAFHEPHE_01964 4.8e-215 rfbX S Membrane protein involved in the export of O-antigen and teichoic acid
HAFHEPHE_01965 2.3e-178 glf 5.4.99.9 M UDP-galactopyranose mutase
HAFHEPHE_01966 1.4e-47 ganB 3.2.1.89 G arabinogalactan
HAFHEPHE_01967 0.0 ganB 3.2.1.89 G arabinogalactan
HAFHEPHE_01968 1.1e-83 ganB 3.2.1.89 G arabinogalactan
HAFHEPHE_01969 1e-287 3.5.1.28 M Ami_3
HAFHEPHE_01971 2.1e-25
HAFHEPHE_01972 0.0 G Peptidase_C39 like family
HAFHEPHE_01973 0.0 2.7.7.6 M Peptidase family M23
HAFHEPHE_01974 2.9e-119 rfbP 2.7.8.6 M Bacterial sugar transferase
HAFHEPHE_01975 6.3e-176 yfdH 2.4.2.53 GT2 M Glycosyltransferase, group 2 family protein
HAFHEPHE_01976 2.7e-148 cps1D M Domain of unknown function (DUF4422)
HAFHEPHE_01977 9e-139 recX 2.4.1.337 GT4 S Regulatory protein RecX
HAFHEPHE_01978 2.2e-31
HAFHEPHE_01979 6.6e-34 S Protein of unknown function (DUF2922)
HAFHEPHE_01980 1.6e-152 yihY S Belongs to the UPF0761 family
HAFHEPHE_01981 6.9e-281 yjeM E Amino Acid
HAFHEPHE_01982 8.6e-257 E Arginine ornithine antiporter
HAFHEPHE_01983 1.3e-220 arcT 2.6.1.1 E Aminotransferase
HAFHEPHE_01984 5.5e-166 map 3.4.11.18 E Methionine Aminopeptidase
HAFHEPHE_01985 1.4e-78 fld C Flavodoxin
HAFHEPHE_01986 2.5e-74 gtcA S Teichoic acid glycosylation protein
HAFHEPHE_01987 7.9e-205 mnaA 5.1.3.14 G Belongs to the UDP-N-acetylglucosamine 2-epimerase family
HAFHEPHE_01989 2.4e-229 yfmL L DEAD DEAH box helicase
HAFHEPHE_01990 4.5e-191 mocA S Oxidoreductase
HAFHEPHE_01991 9.1e-62 S Domain of unknown function (DUF4828)
HAFHEPHE_01992 1.3e-107 yvdD 3.2.2.10 S Belongs to the LOG family
HAFHEPHE_01993 1.5e-164 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
HAFHEPHE_01994 3.1e-297 gshF 6.3.2.2 H Belongs to the glutamate--cysteine ligase type 1 family
HAFHEPHE_01995 3e-195 S Protein of unknown function (DUF3114)
HAFHEPHE_01996 2.7e-79 yjcF 3.5.4.33, 4.4.1.8 K protein acetylation
HAFHEPHE_01997 3.5e-118 ybhL S Belongs to the BI1 family
HAFHEPHE_01998 6.7e-78 yhjX P Major Facilitator Superfamily
HAFHEPHE_01999 7.1e-21
HAFHEPHE_02000 1.5e-248 cshA 3.6.4.13 F DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
HAFHEPHE_02001 2.3e-254 murF 6.3.2.10 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
HAFHEPHE_02002 5.8e-158 htpX O Belongs to the peptidase M48B family
HAFHEPHE_02003 7e-93 lemA S LemA family
HAFHEPHE_02004 1.8e-86 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HAFHEPHE_02005 3.5e-120 pgm3 G Belongs to the phosphoglycerate mutase family
HAFHEPHE_02006 3.7e-162 fba 4.1.2.13, 4.1.2.29 G Fructose-1,6-bisphosphate aldolase, class II
HAFHEPHE_02007 1.7e-137 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
HAFHEPHE_02008 6.3e-156 3.2.1.55 GH51 G Right handed beta helix region
HAFHEPHE_02009 0.0 ppsA 2.7.9.2 H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate
HAFHEPHE_02010 2.1e-123 srtA 3.4.22.70 M sortase family
HAFHEPHE_02011 2.7e-163 S Alpha/beta hydrolase of unknown function (DUF915)
HAFHEPHE_02012 1.9e-234 pts13C G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HAFHEPHE_02013 4.6e-41 rpmE2 J Ribosomal protein L31
HAFHEPHE_02014 2e-236 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HAFHEPHE_02015 0.0 pyrG 6.3.4.2 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
HAFHEPHE_02016 8.7e-51 rpoE K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
HAFHEPHE_02017 4.6e-67 ywiB S Domain of unknown function (DUF1934)
HAFHEPHE_02018 2.5e-152 lipL 2.3.1.200, 2.3.1.204 H biotin lipoate A B protein ligase
HAFHEPHE_02019 3.6e-268 ywfO S HD domain protein
HAFHEPHE_02020 2.3e-145 yxeH S hydrolase
HAFHEPHE_02021 4.4e-112 rarA L recombination factor protein RarA
HAFHEPHE_02022 3.3e-51 rarA L recombination factor protein RarA
HAFHEPHE_02023 7.3e-50
HAFHEPHE_02024 3.2e-178 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HAFHEPHE_02025 1.7e-241 glmU 2.3.1.157, 2.7.7.23 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HAFHEPHE_02026 6.9e-150 purR 2.4.2.22, 2.4.2.7 F pur operon repressor
HAFHEPHE_02027 1.2e-127 znuB U ABC 3 transport family
HAFHEPHE_02028 7.7e-123 fhuC P ABC transporter
HAFHEPHE_02029 7.6e-166 znuA P Belongs to the bacterial solute-binding protein 9 family
HAFHEPHE_02030 6.9e-161 ispE 2.1.1.182, 2.7.1.148 F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HAFHEPHE_02031 6.8e-37 veg S Biofilm formation stimulator VEG
HAFHEPHE_02032 6.8e-159 ksgA 2.1.1.182 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
HAFHEPHE_02033 5.5e-98 rnmV 3.1.26.8 J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HAFHEPHE_02034 3.9e-153 tatD L hydrolase, TatD family
HAFHEPHE_02035 0.0 metG 6.1.1.10 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HAFHEPHE_02036 2e-160 yunF F Protein of unknown function DUF72
HAFHEPHE_02038 5.2e-130 cobB K SIR2 family
HAFHEPHE_02039 1.9e-175
HAFHEPHE_02040 4.4e-228 mvaA 1.1.1.34, 1.1.1.88, 2.3.1.9 C Belongs to the HMG-CoA reductase family
HAFHEPHE_02041 1.8e-165 ppx 3.6.1.11, 3.6.1.40 FP exopolyphosphatase
HAFHEPHE_02042 1e-190 trpS 6.1.1.2 J Belongs to the class-I aminoacyl-tRNA synthetase family
HAFHEPHE_02043 1.5e-183 hpaIM 2.1.1.72 L Belongs to the N(4) N(6)-methyltransferase family
HAFHEPHE_02044 2.2e-81 ndk 2.7.4.6 F Belongs to the NDK family
HAFHEPHE_02045 0.0 helD 3.6.4.12 L DNA helicase
HAFHEPHE_02046 6.9e-204 napA P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
HAFHEPHE_02048 1.5e-255 gabT 2.6.1.19 E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HAFHEPHE_02049 2.8e-266 yfnA E amino acid
HAFHEPHE_02050 3.5e-117 nth 4.2.99.18 L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HAFHEPHE_02051 2.8e-45 1.3.5.4 S FMN binding
HAFHEPHE_02052 2.9e-221 norA EGP Major facilitator Superfamily
HAFHEPHE_02053 2e-169 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
HAFHEPHE_02054 3.3e-155 metQ1 P Belongs to the nlpA lipoprotein family
HAFHEPHE_02055 1.9e-192 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HAFHEPHE_02056 3.1e-103 metI P ABC transporter permease
HAFHEPHE_02057 5.7e-219 argE 3.5.1.18 E succinyl-diaminopimelate desuccinylase
HAFHEPHE_02058 1.2e-249 clcA P chloride
HAFHEPHE_02059 6.3e-78 msrB 1.8.4.11, 1.8.4.12 O peptide methionine sulfoxide reductase
HAFHEPHE_02060 1.4e-102 proW P ABC transporter, permease protein
HAFHEPHE_02061 8.8e-139 proV E ABC transporter, ATP-binding protein
HAFHEPHE_02062 1.4e-108 proWZ P ABC transporter permease
HAFHEPHE_02063 2.1e-160 proX M ABC transporter, substrate-binding protein, QAT family
HAFHEPHE_02064 1.8e-75 K Transcriptional regulator
HAFHEPHE_02065 4.8e-121 1.6.5.2 GM NAD(P)H-binding
HAFHEPHE_02066 1.8e-07
HAFHEPHE_02067 1.1e-204 5.4.2.7 G Metalloenzyme superfamily
HAFHEPHE_02068 0.0 cadA P P-type ATPase
HAFHEPHE_02069 1.4e-130 XK27_08875 O PFAM peptidase M10A and M12B, matrixin and adamalysin
HAFHEPHE_02070 1.2e-123
HAFHEPHE_02071 2.6e-52 S Sugar efflux transporter for intercellular exchange
HAFHEPHE_02072 2.9e-246 merA 1.16.1.1, 1.8.1.7 C Pyridine nucleotide-disulfide oxidoreductase
HAFHEPHE_02074 0.0 L Helicase C-terminal domain protein
HAFHEPHE_02075 7.1e-81 3.1.3.27, 3.1.3.4, 3.1.3.81, 3.6.1.27 I PAP2 superfamily
HAFHEPHE_02076 3.8e-176 S Aldo keto reductase

eggNOG-mapper v2 (Database: eggNOG v5.0, Jul. 2018 release)