ORF_ID e_value Gene_name EC_number CAZy COGs Description
KFHDONED_00001 1.3e-257 dnaA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KFHDONED_00002 2e-200 dnaN 2.7.7.7 L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
KFHDONED_00003 1.1e-29 yyzM S Protein conserved in bacteria
KFHDONED_00004 8.6e-204 ychF J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
KFHDONED_00005 1.4e-104 pth 3.1.1.29 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
KFHDONED_00006 0.0 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KFHDONED_00007 1.7e-39 yabO J Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
KFHDONED_00008 2.7e-61 divIC D Septum formation initiator
KFHDONED_00010 1.3e-240 XK27_09285 3.5.2.6 V Beta-lactamase enzyme family
KFHDONED_00011 5.5e-239 tilS 2.4.2.8, 6.3.4.19 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
KFHDONED_00012 3.4e-97 hpt 2.4.2.8, 6.3.4.19 F Belongs to the purine pyrimidine phosphoribosyltransferase family
KFHDONED_00013 0.0 ftsH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KFHDONED_00014 7.1e-152 L Transposase
KFHDONED_00015 1.4e-87 L Transposase
KFHDONED_00016 4.2e-29 L transposition
KFHDONED_00017 6.5e-87 L Integrase core domain protein
KFHDONED_00030 5.3e-11
KFHDONED_00036 2.1e-138 mreC M Involved in formation and maintenance of cell shape
KFHDONED_00037 8.2e-88 mreD M Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
KFHDONED_00038 3.5e-93 usp 3.5.1.28 CBM50 S CHAP domain
KFHDONED_00039 1.2e-174 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KFHDONED_00040 2.5e-26
KFHDONED_00041 5.9e-219 araT 2.6.1.1 E Aminotransferase
KFHDONED_00042 2.6e-143 recO L Involved in DNA repair and RecF pathway recombination
KFHDONED_00043 2.5e-178 plsX 2.3.1.15 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
KFHDONED_00044 4.2e-34 acpP1 IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
KFHDONED_00045 2e-129 purC 4.1.1.21, 4.3.2.2, 6.3.2.6 F Belongs to the SAICAR synthetase family
KFHDONED_00046 0.0 purL 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KFHDONED_00047 1.3e-276 purF 2.4.2.14 F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KFHDONED_00048 4.8e-185 purM 6.3.3.1, 6.3.4.13 F Phosphoribosylformylglycinamidine cyclo-ligase
KFHDONED_00049 8.9e-101 purN 2.1.2.2 F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KFHDONED_00050 4.4e-291 purH 2.1.2.3, 3.5.4.10 F Bifunctional purine biosynthesis protein PurH
KFHDONED_00051 4.7e-24 L transposase activity
KFHDONED_00052 5.5e-10 L transposase activity
KFHDONED_00053 1.5e-30 L transposition
KFHDONED_00054 1.4e-33 L Integrase core domain protein
KFHDONED_00055 1.2e-160 S CHAP domain
KFHDONED_00056 2.6e-241 purD 6.3.4.13 F Belongs to the GARS family
KFHDONED_00057 4.9e-76 purE 5.4.99.18 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KFHDONED_00058 2.2e-204 purK 6.3.4.18 F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KFHDONED_00059 9.4e-124 1.1.1.169 H Ketopantoate reductase
KFHDONED_00060 1.6e-32
KFHDONED_00061 8.7e-248 purB 4.3.2.2 F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KFHDONED_00062 0.0 argS 6.1.1.19 J Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
KFHDONED_00063 1.2e-68 argR K Regulates arginine biosynthesis genes
KFHDONED_00064 2.3e-57 ymcA 3.6.3.21 S Belongs to the UPF0342 family
KFHDONED_00065 0.0 mutS L that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KFHDONED_00066 3.9e-78 S Protein of unknown function (DUF3021)
KFHDONED_00068 0.0 mutL L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KFHDONED_00070 7.8e-103 ruvA 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
KFHDONED_00071 5.4e-106 tag 3.2.2.20 L 3-methyladenine DNA glycosylase
KFHDONED_00072 2.9e-232 cinA 3.5.1.42 S Belongs to the CinA family
KFHDONED_00073 4.7e-205 recA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KFHDONED_00074 2.3e-66 spxA_2 1.20.4.1 P Belongs to the ArsC family
KFHDONED_00077 7.6e-10
KFHDONED_00080 1.9e-07
KFHDONED_00085 0.0 polC 2.7.7.7 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KFHDONED_00086 3.3e-236 pepS E COG2309 Leucyl aminopeptidase (aminopeptidase T)
KFHDONED_00087 5.5e-36 XK27_02060 S Transglycosylase associated protein
KFHDONED_00088 1.8e-26 badR K DNA-binding transcription factor activity
KFHDONED_00089 7.8e-97 S reductase
KFHDONED_00090 4.5e-32 L Integrase core domain protein
KFHDONED_00091 7.7e-38 L Integrase core domain protein
KFHDONED_00092 6.4e-41 L transposition
KFHDONED_00094 1.8e-75 yocD 3.4.17.13 V carboxypeptidase activity
KFHDONED_00095 4.6e-91 yocD 3.4.17.13 V proteins, homologs of microcin C7 resistance protein MccF
KFHDONED_00097 1.3e-137 rpsB J Belongs to the universal ribosomal protein uS2 family
KFHDONED_00098 1.7e-182 tsf J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KFHDONED_00099 1.1e-83 S Putative small multi-drug export protein
KFHDONED_00100 6.2e-76 ctsR K Belongs to the CtsR family
KFHDONED_00101 0.0 clpC O Belongs to the ClpA ClpB family
KFHDONED_00102 6.6e-125 dacA 3.4.16.4 M Belongs to the peptidase S11 family
KFHDONED_00103 9.3e-52 dacA 3.4.16.4 M Belongs to the peptidase S11 family
KFHDONED_00104 1.4e-231 dacA 3.4.16.4 M Belongs to the peptidase S11 family
KFHDONED_00105 0.0 pnp 2.7.7.8 J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
KFHDONED_00106 2e-143 S SseB protein N-terminal domain
KFHDONED_00107 1.1e-112 cysE 2.3.1.30 E serine acetyltransferase
KFHDONED_00108 1.7e-259 cysS 6.1.1.16, 6.3.1.13 J Belongs to the class-I aminoacyl-tRNA synthetase family
KFHDONED_00109 4.2e-68 mrnC J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
KFHDONED_00112 5.7e-135 trmH 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KFHDONED_00113 7e-92 yacP S RNA-binding protein containing a PIN domain
KFHDONED_00114 3.7e-154 degV S DegV family
KFHDONED_00117 2.5e-18 K helix-turn-helix
KFHDONED_00118 3.6e-182 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KFHDONED_00119 2e-79 rplM J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KFHDONED_00120 9.5e-65 rpsI J Belongs to the universal ribosomal protein uS9 family
KFHDONED_00121 4.1e-36 K sequence-specific DNA binding
KFHDONED_00123 6.8e-78 S Lantibiotic dehydratase, C terminus
KFHDONED_00124 0.0 S Lantibiotic dehydratase, C terminus
KFHDONED_00125 9.5e-231 spaC2 V Lanthionine synthetase C family protein
KFHDONED_00126 7.3e-183 EGP Major facilitator Superfamily
KFHDONED_00127 1.6e-91 3.6.4.12 K Divergent AAA domain protein
KFHDONED_00128 1.4e-50 int L Belongs to the 'phage' integrase family
KFHDONED_00129 1.3e-27 int L Belongs to the 'phage' integrase family
KFHDONED_00130 3.9e-41 S Helix-turn-helix domain
KFHDONED_00131 2.1e-120
KFHDONED_00132 1.9e-26 isp2 S pathogenesis
KFHDONED_00133 5.7e-91 tnp L Transposase
KFHDONED_00134 6.9e-143 capA M Bacterial capsule synthesis protein
KFHDONED_00135 2.5e-58 capA M Bacterial capsule synthesis protein
KFHDONED_00136 3.6e-39 gcvR T UPF0237 protein
KFHDONED_00137 1.7e-243 XK27_08635 S UPF0210 protein
KFHDONED_00138 3e-133 ais G Phosphoglycerate mutase
KFHDONED_00139 1.3e-140 vanY 3.4.17.14 M D-alanyl-D-alanine carboxypeptidase
KFHDONED_00140 1.2e-100 acmA 3.2.1.17 NU amidase activity
KFHDONED_00141 5.3e-198 hrcA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
KFHDONED_00142 1.3e-71 grpE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KFHDONED_00143 4.9e-297 dnaK O Heat shock 70 kDa protein
KFHDONED_00144 4.2e-190 dnaJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
KFHDONED_00145 7.7e-140 truA 5.4.99.12 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
KFHDONED_00146 3.6e-137 thiD 2.7.1.35, 2.7.1.49, 2.7.4.7 H phosphomethylpyrimidine kinase
KFHDONED_00147 1e-71 hmpT S cog cog4720
KFHDONED_00160 0.0 amiA E ABC transporter, substrate-binding protein, family 5
KFHDONED_00161 9e-23 L Transposase
KFHDONED_00162 2.6e-43 L Transposase
KFHDONED_00163 3e-214 gadB 4.1.1.15 E Belongs to the group II decarboxylase family
KFHDONED_00164 1.7e-175 gadC E Psort location CytoplasmicMembrane, score 10.00
KFHDONED_00166 4.4e-25 L Transposase and inactivated derivatives, TnpA family
KFHDONED_00167 4.6e-31 tnp L Transposase
KFHDONED_00168 5.1e-63 L Transposase
KFHDONED_00169 3.3e-12
KFHDONED_00170 3e-63 tdcF 3.5.99.10 J endoribonuclease L-PSP
KFHDONED_00171 2.2e-122 queC 6.3.4.20 F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KFHDONED_00172 2e-82 queD 4.1.2.50, 4.2.3.12 H synthase
KFHDONED_00173 2.9e-136 queE 1.97.1.4, 4.3.99.3 H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
KFHDONED_00174 6.5e-95 queF 1.7.1.13 S Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily
KFHDONED_00175 1.6e-19 D nuclear chromosome segregation
KFHDONED_00176 2.8e-137 yejC S cyclic nucleotide-binding protein
KFHDONED_00177 1.2e-163 rapZ S Displays ATPase and GTPase activities
KFHDONED_00178 3.6e-182 ybhK S Required for morphogenesis under gluconeogenic growth conditions
KFHDONED_00179 8.7e-162 whiA K May be required for sporulation
KFHDONED_00180 2.9e-139 pepD E Dipeptidase
KFHDONED_00181 5.4e-32 cspD K Cold shock protein domain
KFHDONED_00182 2.7e-42 K Cold-Shock Protein
KFHDONED_00183 6.7e-223 L Transposase
KFHDONED_00184 0.0 copB 3.6.3.4 P P-type ATPase
KFHDONED_00185 6.3e-44 L Transposase
KFHDONED_00186 4e-156 L Transposase, Mutator family
KFHDONED_00187 4.2e-189 3.1.21.3 L Subunit R is required for both nuclease and ATPase activities, but not for modification
KFHDONED_00188 2.3e-170 mccA 2.5.1.134, 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
KFHDONED_00189 9.1e-220 metC 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
KFHDONED_00190 3.7e-97 cysE 2.3.1.30 E serine acetyltransferase
KFHDONED_00191 5.9e-194 L Transposase
KFHDONED_00192 1.6e-57 hsdS 2.1.1.72, 3.1.21.3 V type I restriction modification DNA specificity domain
KFHDONED_00193 5.8e-112 hsdM 2.1.1.72 V type I restriction-modification system
KFHDONED_00194 2.2e-157 glcU U Glucose uptake
KFHDONED_00195 1.1e-08 mycA 4.2.1.53 S Myosin-crossreactive antigen
KFHDONED_00196 3.4e-79 hsdM 2.1.1.72 V HsdM N-terminal domain
KFHDONED_00197 7.7e-86 XK27_10720 D peptidase activity
KFHDONED_00198 1.4e-292 adcA P Belongs to the bacterial solute-binding protein 9 family
KFHDONED_00199 5.8e-09
KFHDONED_00200 8.7e-171 yeiH S Membrane
KFHDONED_00201 7.2e-119 mur1 NU muramidase
KFHDONED_00202 4.1e-86 L overlaps another CDS with the same product name
KFHDONED_00203 2.6e-166 cpsY K Transcriptional regulator
KFHDONED_00204 0.0 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
KFHDONED_00205 2.5e-58 phnA P Alkylphosphonate utilization operon protein PhnA
KFHDONED_00206 2e-104 artQ P ABC transporter (Permease
KFHDONED_00207 1.8e-113 glnQ 3.6.3.21 E abc transporter atp-binding protein
KFHDONED_00208 1.1e-158 aatB ET ABC transporter substrate-binding protein
KFHDONED_00209 4.9e-140 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KFHDONED_00210 2.1e-07
KFHDONED_00211 2.7e-42 adhP 1.1.1.1 C alcohol dehydrogenase
KFHDONED_00212 2.5e-46 adhP 1.1.1.1 C alcohol dehydrogenase
KFHDONED_00214 5.7e-50 sthIM 2.1.1.72 L Adenine specific DNA methylase Mod
KFHDONED_00215 3.9e-303 guaA 2.3.1.128, 6.3.5.2 F Catalyzes the synthesis of GMP from XMP
KFHDONED_00216 1.6e-126 gntR1 K transcriptional
KFHDONED_00217 1.1e-53 ylxM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
KFHDONED_00218 6.5e-274 ffh 3.6.5.4 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KFHDONED_00219 2e-86 niaX
KFHDONED_00220 6e-91 niaR S small molecule binding protein (contains 3H domain)
KFHDONED_00221 1.8e-127 K DNA-binding helix-turn-helix protein
KFHDONED_00222 1.1e-158 ylqF S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KFHDONED_00223 1.4e-136 rnhB 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KFHDONED_00224 4.8e-168 GK ROK family
KFHDONED_00225 8.3e-159 dprA LU DNA protecting protein DprA
KFHDONED_00226 0.0 topA 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KFHDONED_00227 6.7e-153 S TraX protein
KFHDONED_00228 2.2e-122 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
KFHDONED_00229 8.7e-254 T PhoQ Sensor
KFHDONED_00230 6.6e-259 trmFO 2.1.1.74 J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
KFHDONED_00231 4.8e-102 XK27_05470 E Methionine synthase
KFHDONED_00232 4.8e-37 XK27_05470 E Methionine synthase
KFHDONED_00233 1.7e-75 ndk 2.7.4.6 F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
KFHDONED_00234 1e-47 pspE P Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KFHDONED_00235 6.6e-54 IQ Acetoin reductase
KFHDONED_00236 3.9e-19 IQ Acetoin reductase
KFHDONED_00237 0.0 lepA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
KFHDONED_00240 1.1e-53 K peptidyl-tyrosine sulfation
KFHDONED_00241 6.1e-157 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
KFHDONED_00244 1.3e-212 pqqE C radical SAM domain protein
KFHDONED_00245 3.9e-136 speB 3.5.3.11 E hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
KFHDONED_00246 6.6e-61 EGP Major facilitator Superfamily
KFHDONED_00247 0.0 alsS 2.2.1.6 EH Belongs to the TPP enzyme family
KFHDONED_00248 3e-133 budA 4.1.1.5 H Belongs to the alpha-acetolactate decarboxylase family
KFHDONED_00249 5.3e-226 L Helix-turn-helix domain of transposase family ISL3
KFHDONED_00250 1.4e-14 lytN 3.5.1.104 M LysM domain
KFHDONED_00251 1.7e-224 L Transposase
KFHDONED_00252 1.2e-97 K Transcriptional regulator, TetR family
KFHDONED_00253 8.9e-159 czcD P cation diffusion facilitator family transporter
KFHDONED_00254 1.5e-208 hemH 4.99.1.1, 4.99.1.9 H Catalyzes the ferrous insertion into protoporphyrin IX
KFHDONED_00255 1e-54 adhB 1.1.1.1, 1.1.1.14 E Dehydrogenase
KFHDONED_00256 1e-105 adhB 1.1.1.1, 1.1.1.14 E Dehydrogenase
KFHDONED_00257 6e-08 S Hydrolases of the alpha beta superfamily
KFHDONED_00258 7.9e-17 S Alpha/beta hydrolase of unknown function (DUF915)
KFHDONED_00259 1.7e-78 S Alpha/beta hydrolase of unknown function (DUF915)
KFHDONED_00262 2.6e-143 2.4.2.3 F Phosphorylase superfamily
KFHDONED_00263 3.5e-117 gph 3.1.3.18 S HAD hydrolase, family IA, variant 1
KFHDONED_00264 3.6e-14 yclQ P ABC-type enterochelin transport system, periplasmic component
KFHDONED_00265 1.2e-18 yclQ P ABC-type enterochelin transport system, periplasmic component
KFHDONED_00266 1.1e-72 dinF V Mate efflux family protein
KFHDONED_00268 1.3e-309 FbpA K RNA-binding protein homologous to eukaryotic snRNP
KFHDONED_00270 2.4e-111 S TraX protein
KFHDONED_00271 1.7e-96 thiJ 2.7.11.1, 3.5.1.124 S DJ-1 family
KFHDONED_00272 2.2e-148 pyrK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )
KFHDONED_00273 5.5e-175 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
KFHDONED_00274 2.7e-29 cas1 L maintenance of DNA repeat elements
KFHDONED_00275 6e-137 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
KFHDONED_00276 1.3e-34 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
KFHDONED_00277 1.2e-132 cas6 S Pfam:DUF2276
KFHDONED_00278 0.0 csm1 S CRISPR-associated protein Csm1 family
KFHDONED_00279 5.6e-62 csm2 L Pfam:DUF310
KFHDONED_00280 1.1e-116 csm3 L RAMP superfamily
KFHDONED_00281 5.2e-167 csm4 L CRISPR-associated RAMP protein, Csm4 family
KFHDONED_00282 2e-205 csm5 L CRISPR-associated RAMP protein, Csm5 family
KFHDONED_00283 3.4e-61 csm6 S Psort location Cytoplasmic, score
KFHDONED_00284 7e-127 pyrF 4.1.1.23 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
KFHDONED_00285 5.7e-112 pyrE 2.4.2.10, 4.1.1.23 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KFHDONED_00287 3.6e-48 nylA 3.5.1.4 J Belongs to the amidase family
KFHDONED_00288 1.8e-265 dtpT E transporter
KFHDONED_00289 1.7e-103 nylA 3.5.1.4 J Belongs to the amidase family
KFHDONED_00290 1.2e-98 yckB ET Belongs to the bacterial solute-binding protein 3 family
KFHDONED_00291 7.9e-12 artJ_1 ET Belongs to the bacterial solute-binding protein 3 family
KFHDONED_00292 9.2e-22 yecS P amino acid transport
KFHDONED_00294 6.7e-227 sasH 3.1.3.5, 3.6.1.45 F Belongs to the 5'-nucleotidase family
KFHDONED_00295 1.9e-23 3.1.3.6, 3.1.4.16 F nucleotide catabolic process
KFHDONED_00296 1.1e-25 sasH 3.1.3.5, 3.6.1.45 F Belongs to the 5'-nucleotidase family
KFHDONED_00297 4e-38 yfiF3 K sequence-specific DNA binding
KFHDONED_00298 1.6e-247 mnmE S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KFHDONED_00299 1.8e-240 agcS E (Alanine) symporter
KFHDONED_00300 0.0 pcrA 3.6.4.12 L ATP-dependent DNA helicase
KFHDONED_00301 4.6e-241 metY 2.5.1.49 E o-acetylhomoserine
KFHDONED_00302 9.3e-62 S haloacid dehalogenase-like hydrolase
KFHDONED_00303 6.5e-87 tpx 1.11.1.15 O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KFHDONED_00304 3.1e-110 hsdS2 2.1.1.72 V Type I restriction modification DNA specificity domain
KFHDONED_00305 6.1e-139 XK27_04775 S hemerythrin HHE cation binding domain
KFHDONED_00306 5.2e-22 XK27_04775 P Hemerythrin HHE cation binding domain protein
KFHDONED_00307 8.4e-151 truB 5.4.99.25 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KFHDONED_00308 3.2e-172 ribF 2.7.1.26, 2.7.7.2 H Belongs to the ribF family
KFHDONED_00309 1.4e-71 spxA 1.20.4.1 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
KFHDONED_00310 2.3e-44 yktA S Belongs to the UPF0223 family
KFHDONED_00311 6.5e-142 suhB 3.1.3.25 G Belongs to the inositol monophosphatase superfamily
KFHDONED_00312 1.5e-255 rsmF 2.1.1.176, 2.1.1.178 J NOL1 NOP2 sun family protein
KFHDONED_00313 3.3e-158 pstS P phosphate
KFHDONED_00314 2.5e-156 pstC P probably responsible for the translocation of the substrate across the membrane
KFHDONED_00315 1.2e-155 pstA P phosphate transport system permease
KFHDONED_00316 1e-150 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
KFHDONED_00317 1.7e-139 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
KFHDONED_00318 2.4e-113 phoU P Plays a role in the regulation of phosphate uptake
KFHDONED_00319 0.0 pepN 3.4.11.2 E aminopeptidase
KFHDONED_00320 7e-195 xerS D Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division
KFHDONED_00322 1.3e-187 lplA 6.3.1.20 H Lipoate-protein ligase
KFHDONED_00324 3.2e-08
KFHDONED_00325 0.0 glgP 2.4.1.1 GT35 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
KFHDONED_00326 3.4e-304 malQ 2.4.1.25 GH77 G 4-alpha-glucanotransferase
KFHDONED_00327 5.6e-178 malR K Transcriptional regulator
KFHDONED_00328 2e-19 malX G ABC transporter
KFHDONED_00329 4.5e-17 malX G maltose binding
KFHDONED_00330 8.5e-50 malX G maltose binding
KFHDONED_00331 1.6e-113 malF P ABC transporter (Permease
KFHDONED_00332 4.6e-25 tatA U protein secretion
KFHDONED_00333 4.4e-121 tatC U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KFHDONED_00334 3e-301 ywbL P COG0672 High-affinity Fe2 Pb2 permease
KFHDONED_00335 1.5e-233 ycdB P peroxidase
KFHDONED_00336 2.1e-152 ycdO P periplasmic lipoprotein involved in iron transport
KFHDONED_00337 1.3e-177 fatB P ABC-type enterochelin transport system, periplasmic component
KFHDONED_00338 2e-135 yclP 3.6.3.34 P abc transporter atp-binding protein
KFHDONED_00339 1.5e-167 fatC P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KFHDONED_00340 8.8e-165 yclN P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KFHDONED_00341 1.2e-122 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
KFHDONED_00342 9.1e-60 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
KFHDONED_00343 9.3e-239 L Transposase
KFHDONED_00344 3.9e-144 EGP Transmembrane secretion effector
KFHDONED_00345 2e-26 P Ferroportin1 (FPN1)
KFHDONED_00346 1.6e-94 6.3.2.2, 6.3.2.4 M ATP-grasp domain
KFHDONED_00347 1.6e-119 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
KFHDONED_00350 8.7e-20 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KFHDONED_00351 4.4e-101 L nUDIX hydrolase
KFHDONED_00352 3.2e-172 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KFHDONED_00353 6.7e-156 K Transcriptional activator, Rgg GadR MutR family
KFHDONED_00354 1.8e-190 L Transposase
KFHDONED_00355 3.4e-30 L Transposase
KFHDONED_00356 9.9e-75 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
KFHDONED_00357 1e-20 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
KFHDONED_00358 0.0 lpdA 1.8.1.4 C Dehydrogenase
KFHDONED_00359 2.1e-199 acoC 2.3.1.12 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
KFHDONED_00360 1.1e-181 acoB 1.2.4.1, 1.2.4.4 C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
KFHDONED_00361 6e-185 acoA 1.2.4.1, 1.2.4.4 C Dehydrogenase E1 component
KFHDONED_00362 5.7e-33 S the current gene model (or a revised gene model) may contain a frame shift
KFHDONED_00363 7e-234 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
KFHDONED_00364 7.7e-128 ung 3.2.2.27 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KFHDONED_00365 3.3e-217 yeaB K Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KFHDONED_00366 3.8e-159 rssA S Phospholipase, patatin family
KFHDONED_00367 1.6e-76 estA E GDSL-like protein
KFHDONED_00368 7e-292 S unusual protein kinase
KFHDONED_00369 1.3e-39 S granule-associated protein
KFHDONED_00370 1.1e-36 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
KFHDONED_00371 3.8e-43 bglH 3.2.1.86 GT1 G beta-glucosidase activity
KFHDONED_00372 3.3e-100 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
KFHDONED_00373 8.5e-199 S hmm pf01594
KFHDONED_00374 8.9e-87 G Belongs to the phosphoglycerate mutase family
KFHDONED_00375 9.9e-70 supH 3.1.3.102, 3.1.3.104 Q phosphatase activity
KFHDONED_00376 2.4e-15 supH 3.1.3.102, 3.1.3.104 S Sucrose-6F-phosphate phosphohydrolase
KFHDONED_00377 7.9e-95 V VanZ like family
KFHDONED_00378 1.4e-201 L Transposase
KFHDONED_00379 8.8e-174 wbbI M transferase activity, transferring glycosyl groups
KFHDONED_00380 7.4e-172 sacB GT2,GT4 M Stealth protein CR2, conserved region 2
KFHDONED_00381 2.8e-215 glf 5.4.99.9 M UDP-galactopyranose mutase
KFHDONED_00382 1.3e-241 epsU S Polysaccharide biosynthesis protein
KFHDONED_00383 7.4e-83 cpsB 3.1.3.48 GM Capsular polysaccharide biosynthesis protein
KFHDONED_00384 9.4e-251 cps4A K Cell envelope-like function transcriptional attenuator common domain protein
KFHDONED_00385 1.7e-44 L Transposase
KFHDONED_00386 4.9e-145 L Transposase
KFHDONED_00387 3.8e-24
KFHDONED_00388 8.6e-26 2.3.1.157, 2.3.1.79, 2.7.7.23 S maltose O-acetyltransferase activity
KFHDONED_00389 1.1e-77
KFHDONED_00390 1.2e-70 S Glycosyltransferase like family 2
KFHDONED_00391 1.1e-46 M Glycosyl transferases group 1
KFHDONED_00392 7.1e-70 lsgF M transferase activity, transferring glycosyl groups
KFHDONED_00393 1.4e-40 L Transposase DDE domain
KFHDONED_00394 2.5e-61 rfbP 2.7.8.6 M sugar transferase
KFHDONED_00395 3e-90 rfbP 2.7.8.6 M Bacterial sugar transferase
KFHDONED_00396 1.3e-115 cpsD D COG0489 ATPases involved in chromosome partitioning
KFHDONED_00397 8.5e-109 cps4C M biosynthesis protein
KFHDONED_00398 3e-136 cpsB 3.1.3.48 GM Capsular polysaccharide biosynthesis protein
KFHDONED_00399 1.6e-250 cps4A K Cell envelope-like function transcriptional attenuator common domain protein
KFHDONED_00400 9e-130 deoD 2.4.2.1, 2.4.2.28 F purine nucleoside phosphorylase
KFHDONED_00401 4.3e-95 yfeJ 6.3.5.2 F glutamine amidotransferase
KFHDONED_00402 2.6e-10 yfeJ 6.3.5.2 F glutamine amidotransferase
KFHDONED_00403 3.3e-49 clcA_2 P chloride channel
KFHDONED_00404 6.8e-150 punA 2.4.2.1 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KFHDONED_00405 3.9e-80 S Protein of unknown function (DUF1697)
KFHDONED_00406 2.9e-237 deoB 5.4.2.7 G Phosphotransfer between the C1 and C5 carbon atoms of pentose
KFHDONED_00407 5e-122 rpiA 2.7.1.12, 2.7.1.15, 5.3.1.6 G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KFHDONED_00408 5.5e-22 V Glucan-binding protein C
KFHDONED_00409 9.1e-112 ung2 3.2.2.27 L Uracil-DNA glycosylase
KFHDONED_00410 2.4e-275 pepV 3.5.1.18 E Dipeptidase
KFHDONED_00411 6.4e-27 dmpI 5.3.2.6 G Belongs to the 4-oxalocrotonate tautomerase family
KFHDONED_00412 3.4e-48 XK27_03610 K Gnat family
KFHDONED_00413 4.8e-16 XK27_03610 K Gnat family
KFHDONED_00414 1.5e-56 rplT J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KFHDONED_00415 2.1e-28 rpmI J Belongs to the bacterial ribosomal protein bL35 family
KFHDONED_00416 9.8e-89 infC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KFHDONED_00417 1.1e-121 cmk 1.17.7.4, 2.5.1.19, 2.7.1.26, 2.7.4.25, 2.7.7.2, 6.3.2.1 F Belongs to the cytidylate kinase family. Type 1 subfamily
KFHDONED_00418 5e-23 M LysM domain
KFHDONED_00419 2.9e-90 ebsA S Family of unknown function (DUF5322)
KFHDONED_00420 2.2e-232 pepT 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
KFHDONED_00421 1.2e-97 lepB 3.4.21.89 U Belongs to the peptidase S26 family
KFHDONED_00422 3.7e-224 G COG0457 FOG TPR repeat
KFHDONED_00423 6.2e-176 yubA S permease
KFHDONED_00424 3.5e-93 mutX 3.6.1.55 F NTP pyrophosphohydrolases including oxidative damage repair enzymes
KFHDONED_00425 1.2e-161 ftsX D Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation
KFHDONED_00426 5.5e-124 ftsE D cell division ATP-binding protein FtsE
KFHDONED_00427 7.4e-183 prfB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KFHDONED_00428 2.7e-202 queG 1.17.99.6 C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KFHDONED_00429 1.7e-181 yjjH S Calcineurin-like phosphoesterase
KFHDONED_00430 6.7e-136 nfrA 1.5.1.38, 1.5.1.39 C nitroreductase
KFHDONED_00431 0.0 pacL 3.6.3.8 P cation transport ATPase
KFHDONED_00432 2.6e-67 ywiB S Domain of unknown function (DUF1934)
KFHDONED_00433 9.2e-147 yidA S hydrolases of the HAD superfamily
KFHDONED_00434 4.5e-230 murM 2.3.2.10, 2.3.2.16 V protein involved in methicillin resistance
KFHDONED_00435 2.1e-154 vicX 3.1.26.11 S Metal-dependent hydrolases of the beta-lactamase superfamily I
KFHDONED_00436 1.9e-229 vicK 2.7.13.3 T Histidine kinase
KFHDONED_00437 9.9e-129 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
KFHDONED_00438 1.9e-138 glnQ 3.6.3.21 E abc transporter atp-binding protein
KFHDONED_00439 4.5e-149 peb1A ET ABC-type amino acid transport signal transduction systems, periplasmic component domain
KFHDONED_00440 5e-117 gltJ P ABC transporter (Permease
KFHDONED_00441 1.7e-111 tcyB_2 P ABC transporter (permease)
KFHDONED_00442 5.5e-129 endA F DNA RNA non-specific endonuclease
KFHDONED_00443 1.2e-25 epuA S DNA-directed RNA polymerase subunit beta
KFHDONED_00444 1.1e-231 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KFHDONED_00446 6e-196 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
KFHDONED_00447 3.5e-24 G Domain of unknown function (DUF4832)
KFHDONED_00448 1.3e-202 metK 2.5.1.6 H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KFHDONED_00449 4.2e-175 birA 6.3.4.15 HK Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
KFHDONED_00450 9.2e-295 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KFHDONED_00451 6.1e-88 ytsP 1.8.4.14 T GAF domain-containing protein
KFHDONED_00452 5.4e-164 miaA 2.5.1.75 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KFHDONED_00453 1.2e-19 WQ51_02665 S Protein of unknown function (DUF3042)
KFHDONED_00456 8.5e-57 rplS J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
KFHDONED_00457 4e-218 XK27_05110 P chloride
KFHDONED_00458 8.7e-41 pheA 1.3.1.12, 2.3.1.79, 4.2.1.51, 5.4.99.5 E Chorismate mutase
KFHDONED_00459 1.3e-282 clcA P Chloride transporter, ClC family
KFHDONED_00460 5.1e-75 fld C Flavodoxin
KFHDONED_00461 2.5e-14 XK27_08880
KFHDONED_00462 4.7e-126 XK27_08875 O Zinc-dependent metalloprotease
KFHDONED_00463 1.6e-151 estA CE1 S Putative esterase
KFHDONED_00464 1.9e-308 rnjB S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KFHDONED_00465 1.2e-135 XK27_08845 S abc transporter atp-binding protein
KFHDONED_00466 1.5e-147 XK27_08840 S Belongs to the binding-protein-dependent transport system permease family
KFHDONED_00467 9.5e-178 XK27_08835 S ABC transporter substrate binding protein
KFHDONED_00468 3.2e-17 S Domain of unknown function (DUF4649)
KFHDONED_00470 1.4e-30 Q the current gene model (or a revised gene model) may contain a frame shift
KFHDONED_00471 5.4e-27 Q the current gene model (or a revised gene model) may contain a frame shift
KFHDONED_00473 1.9e-09 Q the current gene model (or a revised gene model) may contain a frame shift
KFHDONED_00475 3.5e-277 pyk 2.7.1.40, 2.7.7.4 G Belongs to the pyruvate kinase family
KFHDONED_00476 1.2e-188 pfkA 2.7.1.11 F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
KFHDONED_00477 0.0 dnaE 2.7.7.7 L DNA polymerase
KFHDONED_00478 1.4e-152 sua5 2.7.7.87 J Belongs to the SUA5 family
KFHDONED_00479 3.1e-112 leuD 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KFHDONED_00480 6.8e-275 leuC 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KFHDONED_00481 2.5e-43 ysdA L Membrane
KFHDONED_00482 6.6e-190 leuB 1.1.1.85 CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
KFHDONED_00483 7.6e-291 leuA 2.3.3.13 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KFHDONED_00484 4.6e-131 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KFHDONED_00485 2.5e-180 pyrD 1.3.1.14, 1.3.98.1 F Catalyzes the conversion of dihydroorotate to orotate
KFHDONED_00487 2.8e-39 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
KFHDONED_00488 2.6e-95 ypmS S Protein conserved in bacteria
KFHDONED_00489 1.7e-146 ypmR E lipolytic protein G-D-S-L family
KFHDONED_00490 1.1e-147 DegV S DegV family
KFHDONED_00491 7.6e-305 recN L May be involved in recombinational repair of damaged DNA
KFHDONED_00492 1.1e-72 argR K arginine binding
KFHDONED_00493 1.9e-158 rrmJ 2.1.1.226, 2.1.1.227 J Ribosomal RNA large subunit methyltransferase J
KFHDONED_00494 1.9e-158 ispA 2.5.1.1, 2.5.1.10, 2.5.1.29, 2.5.1.90 H Belongs to the FPP GGPP synthase family
KFHDONED_00495 1.8e-28 xseB 3.1.11.6 L exodeoxyribonuclease VII activity
KFHDONED_00496 3.4e-247 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
KFHDONED_00497 7.3e-07 KT response to antibiotic
KFHDONED_00499 1.7e-119 nth 4.2.99.18 L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KFHDONED_00500 2.9e-125 dnaD
KFHDONED_00501 3.9e-181 metA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KFHDONED_00502 2e-94 apt 2.4.2.22, 2.4.2.7 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KFHDONED_00503 0.0 recJ L Single-strand DNA-specific exonuclease, C terminal domain
KFHDONED_00504 1.1e-138 XK27_05435 1.1.1.100 S Belongs to the short-chain dehydrogenases reductases (SDR) family
KFHDONED_00505 2e-174 rnz 3.1.26.11 S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
KFHDONED_00506 4.2e-118 galT 2.7.7.12 G UDPglucose--hexose-1-phosphate uridylyltransferase
KFHDONED_00507 1.9e-223 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KFHDONED_00508 1.1e-238 rodA D Belongs to the SEDS family
KFHDONED_00509 8.1e-91 XK27_08080 3.1.1.53 G Exopolysaccharide biosynthesis protein
KFHDONED_00510 7.9e-10 XK27_08080 3.1.1.53 G Exopolysaccharide biosynthesis protein
KFHDONED_00511 2.7e-45 hisK 3.1.3.15 E Histidinol phosphatase and related hydrolases of the PHP family
KFHDONED_00512 1.4e-78 hisK 3.1.3.15 E Histidinol phosphatase and related hydrolases of the PHP family
KFHDONED_00513 1e-119 ylfI S tigr01906
KFHDONED_00514 5.9e-143 nagD 2.7.1.25, 3.1.3.41 G Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
KFHDONED_00515 1.5e-143 fat 3.1.2.21 I Acyl-ACP thioesterase
KFHDONED_00516 6.9e-217 hemN H Involved in the biosynthesis of porphyrin-containing compound
KFHDONED_00520 1.9e-205 rfbB 4.2.1.46 M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
KFHDONED_00521 8.3e-113 rmlC 1.1.1.133, 5.1.3.13 M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
KFHDONED_00522 2.4e-161 rfbA 2.7.7.24 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
KFHDONED_00523 1.3e-207 yurR 1.4.5.1 E oxidoreductase
KFHDONED_00524 5.2e-103 zupT P Mediates zinc uptake. May also transport other divalent cations
KFHDONED_00525 7e-22 zupT P Mediates zinc uptake. May also transport other divalent cations
KFHDONED_00526 1.6e-148 yqfO 3.5.4.16 S Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KFHDONED_00527 6e-123 trmK 2.1.1.217 S SAM-dependent methyltransferase
KFHDONED_00528 1.3e-70 gtrA S GtrA-like protein
KFHDONED_00529 1.5e-250 glmM 5.4.2.10 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KFHDONED_00530 6e-169 ybbR S Protein conserved in bacteria
KFHDONED_00531 5.6e-124 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KFHDONED_00532 8.3e-254 murD 3.4.21.10, 6.3.2.13, 6.3.2.9 M Mur ligase, middle domain protein
KFHDONED_00533 8.7e-150 cobQ S glutamine amidotransferase
KFHDONED_00534 0.0 mprF 2.3.2.3 J Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KFHDONED_00535 2.2e-131 pip 1.11.1.10 S Alpha beta hydrolase
KFHDONED_00536 6.3e-13 MA20_06245 S yiaA/B two helix domain
KFHDONED_00538 0.0 uup S abc transporter atp-binding protein
KFHDONED_00539 6.2e-114 udk 2.7.1.48 F Cytidine monophosphokinase
KFHDONED_00540 1.3e-177 yfmL 3.6.4.13 L DEAD DEAH box helicase
KFHDONED_00541 4.8e-28 6.3.2.2, 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
KFHDONED_00542 8.6e-265 gapN 1.2.1.9 C Belongs to the aldehyde dehydrogenase family
KFHDONED_00543 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KFHDONED_00544 7.9e-39 ptsH G phosphocarrier protein Hpr
KFHDONED_00545 2.8e-221 icd 1.1.1.42 C Isocitrate dehydrogenase
KFHDONED_00546 1.5e-211 citZ 2.3.3.1 C Belongs to the citrate synthase family
KFHDONED_00547 0.0 acnA 4.2.1.3 C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KFHDONED_00548 2.2e-34 nrdH O Glutaredoxin
KFHDONED_00549 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KFHDONED_00550 1.7e-184 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KFHDONED_00552 4.2e-71 L Transposase (IS116 IS110 IS902 family)
KFHDONED_00553 1.6e-61 L Transposase (IS116 IS110 IS902 family)
KFHDONED_00554 4.9e-163 ypuA S secreted protein
KFHDONED_00555 1.8e-53 yaeR E COG0346 LactoylglutaTHIone lyase and related lyases
KFHDONED_00556 6.7e-131 srtA 3.4.22.70 M Sortase (surface protein transpeptidase)
KFHDONED_00557 0.0 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KFHDONED_00558 1.1e-181 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
KFHDONED_00559 2.8e-257 noxE P NADH oxidase
KFHDONED_00560 2.5e-294 yfmM S abc transporter atp-binding protein
KFHDONED_00561 2.6e-85 pdxK 2.7.1.35 H Belongs to the pyridoxine kinase family
KFHDONED_00562 4.7e-41 pdxK 2.7.1.35 H Belongs to the pyridoxine kinase family
KFHDONED_00563 2e-86 S ECF-type riboflavin transporter, S component
KFHDONED_00565 8.5e-240 XK27_08130 K Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
KFHDONED_00566 7e-56 nrdD_1 1.1.98.6, 1.17.4.1 F Ribonucleoside-triphosphate reductase
KFHDONED_00569 0.0 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
KFHDONED_00570 9.9e-94 paiA 2.3.1.57 K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
KFHDONED_00571 9.6e-197 pheS 6.1.1.20 J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KFHDONED_00572 0.0 smc D Required for chromosome condensation and partitioning
KFHDONED_00573 1.9e-124 rnc 3.1.26.3 J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
KFHDONED_00574 2.3e-173 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KFHDONED_00575 2.3e-198 asd 1.2.1.11 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KFHDONED_00576 2.4e-92 pat 2.3.1.183 M acetyltransferase
KFHDONED_00577 2.1e-11 L Transposase
KFHDONED_00578 9.6e-280 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KFHDONED_00579 0.0 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
KFHDONED_00580 3.1e-127 yjjG 3.1.3.102, 3.1.3.104, 3.1.3.5, 3.8.1.2 E hydrolase
KFHDONED_00581 8e-62 bioY S biotin transmembrane transporter activity
KFHDONED_00582 3.6e-90 proW P Binding-protein-dependent transport system inner membrane component
KFHDONED_00583 1.5e-138 proV E abc transporter atp-binding protein
KFHDONED_00584 2e-169 proX M ABC transporter, substrate-binding protein, QAT family
KFHDONED_00585 3e-111 proWZ P ABC transporter (Permease
KFHDONED_00586 1.4e-281 hutH 4.3.1.3 E Histidine ammonia-lyase
KFHDONED_00587 5.4e-206 S Protein of unknown function (DUF917)
KFHDONED_00588 0.0 hutU 4.2.1.49 E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
KFHDONED_00589 1.9e-121 sdaAB 4.3.1.17 E L-serine dehydratase
KFHDONED_00590 1.6e-149 sdaAA 4.3.1.17 E L-serine dehydratase
KFHDONED_00591 3.3e-26
KFHDONED_00592 2.5e-144 S ABC-2 family transporter protein
KFHDONED_00593 6.6e-99 S transport system, permease component
KFHDONED_00594 6.1e-103 desR K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
KFHDONED_00595 4.7e-194 desK 2.7.13.3 T Histidine kinase
KFHDONED_00596 1.8e-133 yvfS V ABC-2 type transporter
KFHDONED_00597 1e-154 XK27_09825 V abc transporter atp-binding protein
KFHDONED_00600 1.8e-165 yocS S Transporter
KFHDONED_00601 4.4e-82 cdd 2.4.2.4, 3.5.4.5 F cytidine deaminase activity
KFHDONED_00602 4.7e-22 P ABC transporter transmembrane region
KFHDONED_00603 4.1e-34 M translation initiation factor activity
KFHDONED_00604 6.2e-17
KFHDONED_00605 1.6e-60
KFHDONED_00606 8.9e-67 MA20_25245 K Acetyltransferase (GNAT) family
KFHDONED_00607 4.8e-46 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
KFHDONED_00608 2.8e-64 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
KFHDONED_00609 4.1e-66 XK27_01300 S ASCH
KFHDONED_00610 3.9e-08
KFHDONED_00611 1.4e-210 EGP Major facilitator Superfamily
KFHDONED_00612 0.0 2.7.7.73, 2.7.7.80 E metalloendopeptidase activity
KFHDONED_00613 1.8e-151 mutR K Transcriptional activator, Rgg GadR MutR family
KFHDONED_00614 4.4e-49 3.6.1.55 F NUDIX domain
KFHDONED_00616 3.7e-122 S An automated process has identified a potential problem with this gene model
KFHDONED_00617 1.2e-26 XK27_09825 V 'abc transporter, ATP-binding protein
KFHDONED_00618 2.4e-15 liaI KT membrane
KFHDONED_00619 4.4e-30 liaI KT membrane
KFHDONED_00620 1.4e-92 XK27_05000 S Fe-S-cluster oxidoreductase
KFHDONED_00621 0.0 V ABC transporter (permease)
KFHDONED_00622 1.9e-133 macB2 V ABC transporter, ATP-binding protein
KFHDONED_00623 3.1e-165 T Histidine kinase
KFHDONED_00624 7.8e-123 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
KFHDONED_00625 5.7e-66 xpt 2.4.2.22, 2.4.2.7 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
KFHDONED_00627 2.6e-82 pbuX F xanthine permease
KFHDONED_00628 6e-36 pbuX F xanthine permease
KFHDONED_00629 5e-246 norM V Multidrug efflux pump
KFHDONED_00630 2.6e-185 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KFHDONED_00631 2.6e-85 yxeM ET Belongs to the bacterial solute-binding protein 3 family
KFHDONED_00632 3.8e-198 pcaB 4.3.2.2 F Adenylosuccinate lyase
KFHDONED_00633 7.3e-93 yxeO 3.6.3.21 E abc transporter atp-binding protein
KFHDONED_00634 4.1e-63 yxeN U ABC transporter, permease protein
KFHDONED_00635 5.4e-58 yxeL K Acetyltransferase (GNAT) domain
KFHDONED_00636 3e-115 yxeQ S MmgE/PrpD family
KFHDONED_00637 1.6e-147 ykrV3 2.6.1.83 E mutations do not affect methionine salvage in vivo however
KFHDONED_00638 1.6e-101 gldA 1.1.1.1, 1.1.1.6 C glycerol dehydrogenase
KFHDONED_00639 3.2e-07 gldA 1.1.1.1, 1.1.1.6 C glycerol dehydrogenase
KFHDONED_00640 3.9e-183 hipO E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
KFHDONED_00641 5.1e-235 brnQ E Component of the transport system for branched-chain amino acids
KFHDONED_00642 6.5e-66 manA 5.3.1.8 G mannose-6-phosphate isomerase
KFHDONED_00643 2e-58 manA 5.3.1.8 G mannose-6-phosphate isomerase
KFHDONED_00644 6.2e-25 csbD K CsbD-like
KFHDONED_00645 6.2e-228 yfnA E amino acid
KFHDONED_00646 2.4e-107 XK27_02070 S nitroreductase
KFHDONED_00647 5e-15 1.13.11.2 S glyoxalase
KFHDONED_00648 1.2e-88 1.13.11.2 S glyoxalase
KFHDONED_00649 5.6e-77 ywnA K Transcriptional regulator
KFHDONED_00650 4.4e-155 E Alpha/beta hydrolase of unknown function (DUF915)
KFHDONED_00651 8.1e-230 pts13C G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
KFHDONED_00652 1.3e-111 drgA C Nitroreductase
KFHDONED_00653 1.1e-22 yoaK S Protein of unknown function (DUF1275)
KFHDONED_00654 1.7e-69 yoaK S Protein of unknown function (DUF1275)
KFHDONED_00656 3.4e-160 yvgN C reductase
KFHDONED_00657 1.5e-100 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
KFHDONED_00658 1.5e-52 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
KFHDONED_00659 3.3e-283 XK27_07020 S Belongs to the UPF0371 family
KFHDONED_00661 9.6e-37 BP1961 P nitric oxide dioxygenase activity
KFHDONED_00662 3.5e-53 K response regulator
KFHDONED_00663 5.5e-64 S Signal peptide protein, YSIRK family
KFHDONED_00665 6.1e-58
KFHDONED_00666 4.4e-269 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KFHDONED_00667 3.6e-127
KFHDONED_00668 5.3e-12 IQ PFAM AMP-dependent synthetase and ligase
KFHDONED_00669 2.7e-12 IQ PFAM AMP-dependent synthetase and ligase
KFHDONED_00670 5.8e-109 MA20_06410 E LysE type translocator
KFHDONED_00671 5.6e-08
KFHDONED_00672 2.7e-09
KFHDONED_00673 0.0 M family 8
KFHDONED_00674 2e-162 hrtB V MacB-like periplasmic core domain
KFHDONED_00675 1.1e-116 devA 3.6.3.25 V abc transporter atp-binding protein
KFHDONED_00676 1.1e-151 V MatE
KFHDONED_00678 3.9e-110 C Fe-S oxidoreductases
KFHDONED_00679 1.2e-176 EGP Major Facilitator Superfamily
KFHDONED_00680 5.5e-258 I radical SAM domain protein
KFHDONED_00682 6.5e-159 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
KFHDONED_00683 1.4e-150 L Integrase core domain protein
KFHDONED_00684 1.8e-87 L transposase activity
KFHDONED_00686 2.8e-85
KFHDONED_00687 0.0 sbcC L ATPase involved in DNA repair
KFHDONED_00688 2.6e-230 sbcD L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
KFHDONED_00689 0.0 lacL 3.2.1.23 G -beta-galactosidase
KFHDONED_00690 0.0 lacS G transporter
KFHDONED_00691 2.6e-202 galM 5.1.3.3 G Catalyzes the interconversion of alpha and beta anomers of maltose
KFHDONED_00692 1.1e-194 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
KFHDONED_00693 3e-289 galT 2.7.7.12 G UDPglucose--hexose-1-phosphate uridylyltransferase
KFHDONED_00694 4.8e-221 galK 2.7.1.6 G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KFHDONED_00695 1.2e-183 galR K Transcriptional regulator
KFHDONED_00696 7.1e-09 L Integrase core domain protein
KFHDONED_00697 1.2e-25 L transposition
KFHDONED_00698 1.1e-192 M translation initiation factor activity
KFHDONED_00699 2.8e-31 zmpB M M26 IgA1-specific Metallo-endopeptidase C-terminal region
KFHDONED_00700 2.1e-18 rtxA M M26 IgA1-specific Metallo-endopeptidase C-terminal region
KFHDONED_00701 8.5e-102 V abc transporter atp-binding protein
KFHDONED_00702 0.0 gshF 6.3.2.2, 6.3.2.29, 6.3.2.30, 6.3.2.4 H Belongs to the glutamate--cysteine ligase type 1 family
KFHDONED_00703 2.3e-87 L Transposase
KFHDONED_00704 4.1e-181 L Transposase
KFHDONED_00705 6.4e-262 asnS 6.1.1.22 J Catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
KFHDONED_00706 6.5e-218 aspB 2.6.1.1, 2.6.1.14 E Aminotransferase
KFHDONED_00707 2.6e-80 ypmB S Protein conserved in bacteria
KFHDONED_00708 0.0 dinG 2.7.7.7, 3.6.4.12 L helicase involved in DNA repair and perhaps also replication
KFHDONED_00709 3.4e-120 ycbL 3.1.2.6 S COG0491 Zn-dependent hydrolases, including glyoxylases
KFHDONED_00710 6.3e-171 yufQ S Belongs to the binding-protein-dependent transport system permease family
KFHDONED_00711 4e-190 yufP S Belongs to the binding-protein-dependent transport system permease family
KFHDONED_00712 1.1e-281 xylG 3.6.3.17 S ABC transporter, ATP-binding protein
KFHDONED_00713 4e-190 tcsA S ABC-type transport system, periplasmic component surface lipoprotein
KFHDONED_00714 2.9e-66 cdd 2.4.2.2, 3.5.4.5 F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
KFHDONED_00715 1.1e-63 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KFHDONED_00716 6e-21 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KFHDONED_00717 4.6e-98 pdp 2.4.2.2, 2.4.2.4 F Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate
KFHDONED_00718 1e-23 pdp 2.4.2.2, 2.4.2.4 F phosphorylase activity
KFHDONED_00719 2.3e-107 rsmC 2.1.1.172 J Methyltransferase small domain protein
KFHDONED_00720 1.1e-172 coaA 2.7.1.33 F Pantothenic acid kinase
KFHDONED_00721 2.1e-30 rpsT J rRNA binding
KFHDONED_00722 3.9e-122 L Transposase
KFHDONED_00723 1.2e-165 L integrase core domain
KFHDONED_00724 8.3e-78 T PhoQ Sensor
KFHDONED_00725 1.7e-43 T PhoQ Sensor
KFHDONED_00726 2.8e-40 T PhoQ Sensor
KFHDONED_00727 1.5e-89 T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
KFHDONED_00728 0.0 fhs 6.3.4.3 F Belongs to the formate--tetrahydrofolate ligase family
KFHDONED_00729 1.2e-120 coaB 4.1.1.36, 6.3.2.5 H Phosphopantothenate-cysteine ligase
KFHDONED_00730 4.8e-91 coaBC 4.1.1.36, 6.3.2.5 H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KFHDONED_00731 1.1e-93 panT S ECF transporter, substrate-specific component
KFHDONED_00732 0.0 pgm 5.4.2.2, 5.4.2.8 G Phosphoglucomutase
KFHDONED_00733 1.3e-165 metF 1.5.1.20 C reductase
KFHDONED_00734 0.0 metE 2.1.1.14 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KFHDONED_00736 0.0 pabB 2.6.1.85, 4.1.3.27, 4.1.3.38 EH component I
KFHDONED_00737 0.0 3.6.3.8 P cation transport ATPase
KFHDONED_00738 1.6e-19 L transposase activity
KFHDONED_00739 5.5e-10 L transposase activity
KFHDONED_00740 4.8e-49 L transposition
KFHDONED_00741 1.2e-33 L Transposase and inactivated derivatives
KFHDONED_00742 1.2e-32 L Integrase core domain protein
KFHDONED_00743 6.8e-229 dltD M Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
KFHDONED_00744 1.7e-35 dltC 6.1.1.13 IQ Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
KFHDONED_00745 4.6e-238 dltB M Membrane protein involved in D-alanine export
KFHDONED_00746 4.2e-297 dltA 6.1.1.13 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
KFHDONED_00747 0.0 XK27_10035 V abc transporter atp-binding protein
KFHDONED_00748 0.0 yfiB1 V abc transporter atp-binding protein
KFHDONED_00749 6.5e-99 pvaA M lytic transglycosylase activity
KFHDONED_00750 1.2e-177 ndpA S 37-kD nucleoid-associated bacterial protein
KFHDONED_00751 4e-234 glyA 2.1.2.1 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KFHDONED_00752 9.7e-109 ywlC 2.7.7.87, 3.1.3.48 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
KFHDONED_00753 1e-153 prmB 2.1.1.297, 2.1.1.298 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
KFHDONED_00754 3e-193 prfA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KFHDONED_00755 9.3e-112 tdk 2.7.1.21 F thymidine kinase
KFHDONED_00756 4.6e-188 add 3.5.4.4 F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KFHDONED_00757 5.1e-144 gst O Glutathione S-transferase
KFHDONED_00758 1.5e-177 nrnA 3.1.13.3, 3.1.3.7 S domain protein
KFHDONED_00759 2e-177 apbE 2.7.1.180 H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
KFHDONED_00760 2e-45 rpmE2 J 50S ribosomal protein L31
KFHDONED_00761 3e-229 mntH P Mn2 and Fe2 transporters of the NRAMP family
KFHDONED_00762 8.4e-10
KFHDONED_00763 3.8e-16
KFHDONED_00764 0.0 ileS 6.1.1.5 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KFHDONED_00765 7.9e-136 divIVA D Cell division protein DivIVA
KFHDONED_00766 1.2e-143 ylmH T S4 RNA-binding domain
KFHDONED_00767 2.6e-34 yggT D integral membrane protein
KFHDONED_00768 9.8e-95 sepF D Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
KFHDONED_00769 2.7e-123 ylmE S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KFHDONED_00770 5.4e-237 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KFHDONED_00771 8e-252 ftsA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
KFHDONED_00772 3.8e-175 divIB D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
KFHDONED_00773 1.3e-201 murG 2.4.1.227 GT28 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KFHDONED_00774 1.6e-252 murD 6.3.2.9 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KFHDONED_00776 0.0 typA T GTP-binding protein TypA
KFHDONED_00777 2.9e-179 glk 2.7.1.2 G Glucokinase
KFHDONED_00778 8.4e-28 yqgQ S protein conserved in bacteria
KFHDONED_00779 4e-80 perR P Belongs to the Fur family
KFHDONED_00780 1.6e-91 dps P Belongs to the Dps family
KFHDONED_00781 8.8e-116 pilD 3.4.23.43 NOU Bacterial Peptidase A24 N-terminal domain
KFHDONED_00782 2.5e-197 3.5.2.6 V D-alanyl-D-alanine carboxypeptidase
KFHDONED_00783 8.5e-113 sodA 1.15.1.1 C radicals which are normally produced within the cells and which are toxic to biological systems
KFHDONED_00784 2.4e-184 holA 2.7.7.7 L DNA polymerase III delta subunit
KFHDONED_00785 0.0 ppc 4.1.1.31 H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
KFHDONED_00786 1.1e-55 S Domain of unknown function (DUF4430)
KFHDONED_00787 4.2e-75 S Psort location CytoplasmicMembrane, score
KFHDONED_00788 8.4e-141 htpX O Belongs to the peptidase M48B family
KFHDONED_00789 2.6e-92 lemA S LemA family
KFHDONED_00790 7.1e-173 spd F DNA RNA non-specific endonuclease
KFHDONED_00791 2.9e-16 S double-stranded DNA endodeoxyribonuclease activity
KFHDONED_00792 1.1e-303 hsdM 2.1.1.72 V type I restriction-modification system
KFHDONED_00793 6.1e-137 S Protein conserved in bacteria
KFHDONED_00794 6.3e-105
KFHDONED_00795 2.3e-133 hsdS 3.1.21.3 V type I restriction modification DNA specificity domain
KFHDONED_00796 1.9e-215 prrC S AAA domain
KFHDONED_00797 0.0 hsdR 3.1.21.3 L Subunit R is required for both nuclease and ATPase activities, but not for modification
KFHDONED_00798 3.6e-97 sdh 1.1.1.276, 1.1.1.313, 1.1.1.381 S Belongs to the short-chain dehydrogenases reductases (SDR) family
KFHDONED_00799 3.3e-18 sdh 1.1.1.276, 1.1.1.313, 1.1.1.381 S Belongs to the short-chain dehydrogenases reductases (SDR) family
KFHDONED_00800 4.7e-23 MA20_36090 S Protein of unknown function (DUF2974)
KFHDONED_00801 1.4e-23 MA20_36090 S Protein of unknown function (DUF2974)
KFHDONED_00802 2.6e-112 1.14.14.5 C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KFHDONED_00803 2.7e-27 P Hemerythrin HHE cation binding domain protein
KFHDONED_00804 1.6e-145 XK27_00880 3.5.1.28 M Glycosyl hydrolase, family 25
KFHDONED_00805 7.9e-82 ybaK S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KFHDONED_00806 1.5e-115 pgm6 5.4.2.11, 5.4.2.12 G Phosphoglycerate mutase
KFHDONED_00807 2.1e-175 S hydrolase
KFHDONED_00808 7.6e-16
KFHDONED_00809 1.6e-58 M LysM domain
KFHDONED_00810 4.7e-55 M LysM domain
KFHDONED_00811 3.2e-15 M LysM domain
KFHDONED_00812 1.7e-287 lysS 6.1.1.6 J Belongs to the class-II aminoacyl-tRNA synthetase family
KFHDONED_00813 1.6e-27
KFHDONED_00815 5.8e-233 S Domain of unknown function DUF87
KFHDONED_00816 2.4e-208 S SIR2-like domain
KFHDONED_00817 3.7e-226 mutH L DNA mismatch repair enzyme MutH
KFHDONED_00818 1.4e-210 dcm 2.1.1.37 H C-5 cytosine-specific DNA methylase
KFHDONED_00819 1.1e-10
KFHDONED_00820 2.7e-236 mntH P H( )-stimulated, divalent metal cation uptake system
KFHDONED_00821 1.1e-33 XK27_12190 S protein conserved in bacteria
KFHDONED_00823 1.6e-86 bioY S biotin synthase
KFHDONED_00824 3.4e-252 yegQ O Peptidase U32
KFHDONED_00825 3e-178 yegQ O Peptidase U32
KFHDONED_00827 4.6e-68 ytxH S General stress protein
KFHDONED_00829 3.1e-147 lgt 2.1.1.199 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KFHDONED_00830 3.4e-169 hprK F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
KFHDONED_00831 2.9e-41 pspC KT PspC domain
KFHDONED_00832 4.9e-86 ydcK S Belongs to the SprT family
KFHDONED_00833 0.0 yhgF K Transcriptional accessory protein
KFHDONED_00835 5.1e-154 XK27_03015 S permease
KFHDONED_00836 4.2e-147 ycgQ S TIGR03943 family
KFHDONED_00837 4.2e-184 S CRISPR-associated protein Csn2 subfamily St
KFHDONED_00838 3.1e-53 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
KFHDONED_00839 3.2e-172 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
KFHDONED_00840 0.0 cas9 L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
KFHDONED_00841 2.3e-94
KFHDONED_00842 1.2e-34 estA E GDSL-like Lipase/Acylhydrolase
KFHDONED_00843 2.1e-50 dam 2.1.1.72 L D12 class N6 adenine-specific DNA methyltransferase
KFHDONED_00844 1e-31 K Cro/C1-type HTH DNA-binding domain
KFHDONED_00845 2.5e-99
KFHDONED_00846 0.0 L Recombinase
KFHDONED_00847 3.6e-19 K Psort location Cytoplasmic, score
KFHDONED_00849 1.1e-76 S CAAX protease self-immunity
KFHDONED_00850 1.2e-47 blpT
KFHDONED_00851 1.6e-133 L Transposase and inactivated derivatives
KFHDONED_00852 1.7e-75 L transposase activity
KFHDONED_00854 1.6e-12 S Bacteriocin class II with double-glycine leader peptide
KFHDONED_00855 0.0 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
KFHDONED_00856 7.7e-146 mesE M HlyD family secretion protein
KFHDONED_00858 4.5e-122 blpH 2.7.13.3 T GHKL domain
KFHDONED_00859 5.7e-103 blpR KT LytTr DNA-binding domain
KFHDONED_00860 3.3e-21 blpS KT phosphorelay signal transduction system
KFHDONED_00861 5.5e-20
KFHDONED_00862 4.4e-293 U relaxase
KFHDONED_00863 2.1e-50 S Bacterial mobilisation protein (MobC)
KFHDONED_00864 5.9e-53
KFHDONED_00865 1.7e-100
KFHDONED_00866 1.1e-124 K DNA-binding helix-turn-helix protein
KFHDONED_00868 2.6e-56 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KFHDONED_00869 1.8e-195 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KFHDONED_00870 1.8e-57
KFHDONED_00871 1.2e-43
KFHDONED_00872 8e-37
KFHDONED_00873 3.3e-49
KFHDONED_00874 1.5e-17
KFHDONED_00875 1.3e-196 L Protein of unknown function (DUF3991)
KFHDONED_00876 9.3e-102
KFHDONED_00877 3.5e-113 S ABC-2 family transporter protein
KFHDONED_00878 3.7e-111 prrC V abc transporter atp-binding protein
KFHDONED_00880 1.7e-59 yydH S Peptidase M50
KFHDONED_00881 2.7e-126 S Radical SAM superfamily
KFHDONED_00882 3.3e-222 L Transposase
KFHDONED_00883 3.5e-72 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
KFHDONED_00884 1.5e-38
KFHDONED_00885 1.9e-41
KFHDONED_00886 0.0 XK27_00500 L SNF2 family N-terminal domain
KFHDONED_00887 1.7e-91 XK27_00505
KFHDONED_00888 4.9e-14 XK27_00510
KFHDONED_00889 0.0 XK27_00515 D Glucan-binding protein C
KFHDONED_00890 1.7e-153 V Abi-like protein
KFHDONED_00891 0.0 XK27_00530 S CHAP domain
KFHDONED_00892 0.0 U 'COG3451 Type IV secretory pathway, VirB4 components'
KFHDONED_00893 7.5e-61 XK27_00550 S PrgI family protein
KFHDONED_00894 2e-139
KFHDONED_00895 9.2e-34 XK27_00560
KFHDONED_00896 0.0 traG U Type IV secretory system Conjugative DNA transfer
KFHDONED_00897 2.9e-79 XK27_00570
KFHDONED_00898 1.2e-90 ypbD S CAAX protease self-immunity
KFHDONED_00899 5.9e-38 XK27_00580
KFHDONED_00900 4.2e-65 XK27_00585 P arsenate reductase (glutaredoxin) activity
KFHDONED_00901 6.3e-78 XK27_00590
KFHDONED_00902 3e-259 hpaIIM 2.1.1.37 H C-5 cytosine-specific DNA methylase
KFHDONED_00903 1.3e-137 repA S Replication initiator protein A (RepA) N-terminus
KFHDONED_00904 2.9e-21
KFHDONED_00905 8.8e-251 rumA 2.1.1.190 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KFHDONED_00906 1.5e-95 mip S hydroperoxide reductase activity
KFHDONED_00907 2.2e-201 I acyl-CoA dehydrogenase
KFHDONED_00908 2e-137 ydiA P C4-dicarboxylate transporter malic acid transport
KFHDONED_00909 2.4e-246 msrR K Transcriptional regulator
KFHDONED_00910 2.3e-153 pheA 4.2.1.51 E Prephenate dehydratase
KFHDONED_00911 2.2e-87 aroK 1.1.1.25, 2.7.1.71, 4.2.1.10, 4.2.3.4 F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KFHDONED_00912 8.3e-235 aroA 1.3.1.12, 1.3.1.43, 2.5.1.19 E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
KFHDONED_00913 2.5e-172 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
KFHDONED_00914 3.2e-53 yheA S Belongs to the UPF0342 family
KFHDONED_00915 8.3e-207 tyrA 1.3.1.12, 1.3.1.43 E prephenate dehydrogenase
KFHDONED_00916 4.5e-219 aroC 4.2.3.5 E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KFHDONED_00917 1e-201 aroB 2.7.1.71, 4.2.3.4 E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KFHDONED_00918 2.9e-162 aroE 1.1.1.25 E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KFHDONED_00919 8.6e-122 aroD 1.1.1.25, 4.2.1.10 E Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
KFHDONED_00920 2e-219 ywbD 2.1.1.191 J Methyltransferase
KFHDONED_00921 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
KFHDONED_00923 1.3e-246 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
KFHDONED_00924 1.3e-78 yueI S Protein of unknown function (DUF1694)
KFHDONED_00925 7.1e-206 glxK 2.7.1.165 G Belongs to the glycerate kinase type-1 family
KFHDONED_00926 2.2e-40 yyaQ V Protein conserved in bacteria
KFHDONED_00927 2.8e-28 yyaQ S YjbR
KFHDONED_00928 2.2e-182 ccpA K Catabolite control protein A
KFHDONED_00929 4.2e-211 pepQ 3.4.13.9 E Belongs to the peptidase M24B family
KFHDONED_00930 1.7e-63 yugI 5.3.1.9 J RNA binding protein, contains ribosomal protein S1 domain
KFHDONED_00931 9e-275 ppiB 5.2.1.8 G PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KFHDONED_00932 1.1e-80 smpB O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
KFHDONED_00933 0.0 rnr J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
KFHDONED_00934 2e-33 secG U Preprotein translocase subunit SecG
KFHDONED_00935 2.9e-221 mdtG EGP Major facilitator Superfamily
KFHDONED_00936 1.1e-104 coaE 2.7.1.24, 3.2.2.23, 4.2.99.18 GH23 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KFHDONED_00937 1.3e-153 fpg 3.2.2.23, 4.2.99.18 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
KFHDONED_00938 1.3e-165 era M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KFHDONED_00939 1.7e-64 dgkA 2.7.1.107, 2.7.1.66 M Diacylglycerol kinase
KFHDONED_00940 5.9e-88 ybeY 2.6.99.2, 3.5.4.5 S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KFHDONED_00941 5.8e-64 licT K transcriptional antiterminator
KFHDONED_00942 2.2e-105 recR L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KFHDONED_00943 0.0 pbp2b 3.4.16.4 M penicillin-binding protein
KFHDONED_00944 4.6e-149 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KFHDONED_00945 2.7e-157 folD 1.5.1.5, 3.5.4.9 F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KFHDONED_00946 1.5e-23 I Alpha/beta hydrolase family
KFHDONED_00947 1.8e-31 yugF I carboxylic ester hydrolase activity
KFHDONED_00948 6.3e-45 K sequence-specific DNA binding
KFHDONED_00949 2.4e-104 1.1.1.133, 5.1.3.13 M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
KFHDONED_00950 1.5e-07
KFHDONED_00951 0.0 feoB P transporter of a GTP-driven Fe(2 ) uptake system
KFHDONED_00952 1.1e-78 feoA P FeoA domain protein
KFHDONED_00953 1.1e-130 glnQ 3.6.3.21 E abc transporter atp-binding protein
KFHDONED_00954 7.5e-118 WQ51_01820 P Binding-protein-dependent transport system inner membrane component
KFHDONED_00955 1.3e-34 ykuJ S protein conserved in bacteria
KFHDONED_00956 2.1e-182 argF 2.1.3.3 E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KFHDONED_00957 0.0 clpE O Belongs to the ClpA ClpB family
KFHDONED_00958 1.8e-86 mutT 3.5.4.33, 3.6.1.13, 3.6.1.55 L Belongs to the Nudix hydrolase family
KFHDONED_00959 7.4e-49 XK27_09445 S Domain of unknown function (DUF1827)
KFHDONED_00960 2.7e-65 S oxidoreductase
KFHDONED_00961 7.8e-08 S oxidoreductase
KFHDONED_00962 3.2e-231 murN 2.3.2.10, 2.3.2.16 V FemAB family
KFHDONED_00963 5.2e-55 M Pfam SNARE associated Golgi protein
KFHDONED_00964 3.9e-31 S Domain of Unknown Function with PDB structure (DUF3862)
KFHDONED_00965 5.1e-29 S Domain of Unknown Function with PDB structure (DUF3862)
KFHDONED_00968 8.4e-205 rpsA 1.17.7.4 J ribosomal protein S1
KFHDONED_00971 4.8e-16 S Protein of unknown function (DUF2969)
KFHDONED_00972 2.4e-200 ilvE 2.6.1.42 E Aminotransferase
KFHDONED_00973 0.0 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
KFHDONED_00974 0.0 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
KFHDONED_00975 2.7e-101 plsY 2.3.1.15, 3.5.1.104 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
KFHDONED_00976 3.7e-15 L Helix-hairpin-helix DNA-binding motif class 1
KFHDONED_00977 1.4e-29 S Domain of unknown function (DUF1912)
KFHDONED_00978 2.9e-176 mmuM 1.5.1.20, 2.1.1.10 H Homocysteine
KFHDONED_00979 4.4e-250 mmuP E amino acid
KFHDONED_00980 3e-110 engB D Necessary for normal cell division and for the maintenance of normal septation
KFHDONED_00981 2.6e-225 clpX O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KFHDONED_00982 9.7e-22
KFHDONED_00983 1.2e-91 folA 1.5.1.3, 1.5.1.47, 2.1.1.45, 3.5.4.12 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KFHDONED_00984 2.2e-167 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KFHDONED_00985 1.7e-218 mvaS 2.3.3.10 I synthase
KFHDONED_00986 3.8e-232 mvaA 1.1.1.34, 1.1.1.88, 2.3.1.9 C Belongs to the HMG-CoA reductase family
KFHDONED_00987 1e-25 K hmm pf08876
KFHDONED_00988 5.8e-118 yqfA K protein, Hemolysin III
KFHDONED_00989 1.2e-22 S Protein of unknown function (DUF3114)
KFHDONED_00990 4.7e-165 S Protein of unknown function (DUF3114)
KFHDONED_00991 8.4e-168 S hydrolases or acyltransferases (alpha beta hydrolase superfamily)
KFHDONED_00992 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KFHDONED_00993 1.2e-49 XK27_13030
KFHDONED_00994 1.8e-248 mgs 2.4.1.337 GT4 M Glycosyltransferase, group 1 family protein
KFHDONED_00995 5.2e-192 dgs 2.4.1.208 GT4 M Glycosyltransferase, group 1 family protein
KFHDONED_00997 2.1e-50 U protein secretion
KFHDONED_01000 2e-118 mtnN 3.2.2.9 E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KFHDONED_01001 2.5e-21
KFHDONED_01002 1.1e-95 nudF 3.6.1.13 L AdP-ribose pyrophosphatase
KFHDONED_01003 5.6e-253 glmU 2.3.1.157, 2.7.7.23 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KFHDONED_01005 9.9e-191 fni 1.1.1.88, 5.3.3.2 C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
KFHDONED_01006 1.6e-177 mvaK2 2.7.1.36, 2.7.1.43, 2.7.4.2 I GHMP kinases N terminal domain
KFHDONED_01007 6e-174 mvaD 4.1.1.33 I diphosphomevalonate decarboxylase
KFHDONED_01008 5.1e-143 mvk 1.1.1.88, 2.3.3.10, 2.7.1.36 I mevalonate kinase
KFHDONED_01009 2e-94 GBS0088 J protein conserved in bacteria
KFHDONED_01010 2.3e-248 merA 1.16.1.1 C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KFHDONED_01011 1e-46 ald 1.4.1.1 C Belongs to the AlaDH PNT family
KFHDONED_01012 1.2e-17 ald 1.4.1.1 E alanine dehydrogenase activity
KFHDONED_01013 3e-220 hipO 3.5.1.47 E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
KFHDONED_01014 7.4e-132 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
KFHDONED_01015 7.3e-113 S VIT family
KFHDONED_01016 2e-143 deoD_1 2.4.2.3 F Phosphorylase superfamily
KFHDONED_01017 1.9e-22
KFHDONED_01018 1.4e-27 XK27_00085 K Transcriptional
KFHDONED_01019 1.5e-196 yceA S Belongs to the UPF0176 family
KFHDONED_01020 5.4e-122 sagI S ABC-2 type transporter
KFHDONED_01021 2.8e-168 V ABC transporter
KFHDONED_01022 5e-139 2.7.7.73, 2.7.7.80 H Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
KFHDONED_01023 3.2e-72 2.7.7.73, 2.7.7.80 H Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
KFHDONED_01024 1.9e-132 rr02 KT response regulator
KFHDONED_01025 3.3e-215 2.7.13.3 T signal transduction protein with a C-terminal ATPase domain
KFHDONED_01026 2.3e-125 nagB 3.1.1.31, 3.5.99.6 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
KFHDONED_01027 3e-198 queA 2.4.99.17 J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KFHDONED_01028 0.0 lmrA V abc transporter atp-binding protein
KFHDONED_01029 0.0 mdlB V abc transporter atp-binding protein
KFHDONED_01031 3.9e-52 rplL J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
KFHDONED_01032 5.6e-78 rplJ J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KFHDONED_01033 5e-25 ytrF V efflux transmembrane transporter activity
KFHDONED_01034 1.8e-56 V permease protein
KFHDONED_01035 2e-36 acrA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KFHDONED_01036 3.6e-17 acrA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KFHDONED_01037 3.8e-134 2.1.1.223 S Putative SAM-dependent methyltransferase
KFHDONED_01038 0.0 carB 6.3.5.5 F carbamoyl-phosphate synthetase ammonia chain
KFHDONED_01039 2.1e-210 carA 6.3.5.5 F carbamoyl-phosphate synthetase glutamine chain
KFHDONED_01040 1e-173 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
KFHDONED_01041 8.3e-227 pyrP F uracil Permease
KFHDONED_01042 3.7e-88 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
KFHDONED_01043 4.5e-163 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
KFHDONED_01044 7.5e-77 lspA 3.4.23.36 MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KFHDONED_01045 1.4e-167 fhuR K transcriptional regulator (lysR family)
KFHDONED_01048 1.6e-140 ppiA 5.2.1.8 O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KFHDONED_01049 4e-77 pts33BCA G pts system
KFHDONED_01050 1e-94 pts33BCA G pts system
KFHDONED_01051 2.9e-21 pts33BCA G pts system
KFHDONED_01052 2e-40 pts33BCA G pts system
KFHDONED_01053 9.1e-23 pts33BCA G pts system
KFHDONED_01054 1.9e-09 uvrX 2.7.7.7 L impB/mucB/samB family
KFHDONED_01055 2.5e-253 cycA E permease
KFHDONED_01056 4.5e-39 ynzC S UPF0291 protein
KFHDONED_01057 0.0 glyS 6.1.1.14 J Glycyl-tRNA synthetase beta subunit
KFHDONED_01058 4.8e-176 glyQ 6.1.1.14 J glycyl-tRNA synthetase alpha subunit
KFHDONED_01059 7.8e-61
KFHDONED_01060 4.4e-26
KFHDONED_01061 2e-52
KFHDONED_01062 4.4e-219 nagA 3.5.1.25 G Belongs to the metallo-dependent hydrolases superfamily. NagA family
KFHDONED_01063 7.5e-114 nptA P COG1283 Na phosphate symporter
KFHDONED_01064 5.8e-149 XK27_04800 S Sucrose-6F-phosphate phosphohydrolase
KFHDONED_01065 3.2e-105 mur1 NU mannosyl-glycoprotein
KFHDONED_01066 4.3e-53 glnB K Belongs to the P(II) protein family
KFHDONED_01067 5.8e-233 amt P Ammonium Transporter
KFHDONED_01068 2.7e-160 rsmI 2.1.1.198 H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KFHDONED_01069 9.5e-55 yabA L Involved in initiation control of chromosome replication
KFHDONED_01070 2.1e-135 yaaT S stage 0 sporulation protein
KFHDONED_01071 1.9e-161 holB 2.7.7.7 L dna polymerase iii
KFHDONED_01072 1.7e-111 tmk 2.7.4.9 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KFHDONED_01073 8.9e-136 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
KFHDONED_01074 9.5e-225 tuf J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KFHDONED_01075 2.8e-230 ftsW D Belongs to the SEDS family
KFHDONED_01076 5.2e-67 atpC C Produces ATP from ADP in the presence of a proton gradient across the membrane
KFHDONED_01077 2.7e-263 atpD 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KFHDONED_01078 2.5e-158 atpG C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KFHDONED_01079 5e-279 atpA 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KFHDONED_01080 9.3e-87 atpH C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KFHDONED_01081 3.3e-78 atpF C ATP synthase F(0) sector subunit b
KFHDONED_01082 4.3e-124 atpB C it plays a direct role in the translocation of protons across the membrane
KFHDONED_01083 3.2e-16 atpE C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KFHDONED_01084 0.0 valS 6.1.1.9 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
KFHDONED_01085 1.9e-46 2.3.1.128, 5.2.1.8 J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KFHDONED_01086 5.2e-107 S COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KFHDONED_01087 8.9e-14 coiA 3.6.4.12 S Competence protein
KFHDONED_01088 6.4e-15 T peptidase
KFHDONED_01089 2.1e-152 rarD S Transporter
KFHDONED_01090 1.4e-153 thrB 2.7.1.39 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
KFHDONED_01091 1.8e-237 hom 1.1.1.3, 2.7.2.4 E homoserine dehydrogenase
KFHDONED_01092 1.7e-55 yxkH G deacetylase
KFHDONED_01093 5.4e-53 yxkH G deacetylase
KFHDONED_01094 1.1e-209 argD 2.6.1.11, 2.6.1.17 E acetylornithine aminotransferase
KFHDONED_01095 7.1e-130 argB 2.7.2.8 E Belongs to the acetylglutamate kinase family. ArgB subfamily
KFHDONED_01096 1.5e-222 argJ 2.3.1.1, 2.3.1.35, 2.7.2.8 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KFHDONED_01097 1.5e-191 argC 1.2.1.38 E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KFHDONED_01098 1.5e-227 mtnE 2.6.1.83 E mutations do not affect methionine salvage in vivo however
KFHDONED_01099 2.6e-146 cnhA 3.5.1.3 S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
KFHDONED_01100 4.9e-106 3.4.17.14, 3.5.1.28 NU amidase activity
KFHDONED_01101 2e-172 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
KFHDONED_01102 4.6e-24 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
KFHDONED_01103 0.0 alaS 6.1.1.7 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KFHDONED_01104 1.2e-176 prsA 3.1.3.16, 5.2.1.8 O peptidyl-prolyl cis-trans isomerase activity
KFHDONED_01105 1.4e-127 yrrM 2.1.1.104 S O-Methyltransferase
KFHDONED_01106 0.0 pepF E oligoendopeptidase F
KFHDONED_01107 1.6e-185 coiA 3.6.4.12 S Competence protein
KFHDONED_01108 1.2e-166 K transcriptional regulator (lysR family)
KFHDONED_01109 0.0 metG 6.1.1.10, 6.1.1.20 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KFHDONED_01113 8e-191 phoH T phosphate starvation-inducible protein PhoH
KFHDONED_01114 7.5e-60 rlpA M LysM domain protein
KFHDONED_01115 1.3e-103 usp 3.5.1.104, 3.5.1.28 CBM50 S pathogenesis
KFHDONED_01116 7.4e-35 yozE S Belongs to the UPF0346 family
KFHDONED_01117 1.7e-159 cvfB S Protein conserved in bacteria
KFHDONED_01118 9.9e-92 frr J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
KFHDONED_01119 4.9e-131 pyrH 2.7.4.22 F Catalyzes the reversible phosphorylation of UMP to UDP
KFHDONED_01120 8.5e-105 sptS 2.7.13.3 T Histidine kinase
KFHDONED_01121 1.2e-36 K Acetyltransferase (GNAT) family
KFHDONED_01122 0.0 lmrA2 V abc transporter atp-binding protein
KFHDONED_01123 0.0 lmrA1 V abc transporter atp-binding protein
KFHDONED_01124 1.9e-77 K DNA-binding transcription factor activity
KFHDONED_01125 1e-69 def_1 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins
KFHDONED_01126 1.8e-256 gdhA 1.4.1.4 E Belongs to the Glu Leu Phe Val dehydrogenases family
KFHDONED_01127 2.1e-85 nadD 2.7.1.22, 2.7.7.1, 2.7.7.18, 3.6.1.55 H adenylyltransferase
KFHDONED_01128 2.2e-81 nadD 2.7.1.22, 2.7.7.1, 2.7.7.18, 3.6.1.55 H adenylyltransferase
KFHDONED_01129 5.5e-76 3.6.1.13, 3.6.1.55 F AdP-ribose pyrophosphatase
KFHDONED_01130 1.6e-24 U response to pH
KFHDONED_01131 0.0 yfmR S abc transporter atp-binding protein
KFHDONED_01132 1.6e-224 cca 2.7.7.19, 2.7.7.72 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
KFHDONED_01133 5.1e-139 dapB 1.17.1.8 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
KFHDONED_01134 2.9e-54 XK27_08360 T EDD domain protein, DegV family
KFHDONED_01135 2.9e-31 XK27_08360 S lipid binding
KFHDONED_01136 2.6e-64 WQ51_03320 S cog cog4835
KFHDONED_01137 7.7e-126 ydaF_2 J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KFHDONED_01138 1.5e-46 rpmA J Belongs to the bacterial ribosomal protein bL27 family
KFHDONED_01139 4.5e-49 rplU J This protein binds to 23S rRNA in the presence of protein L20
KFHDONED_01140 2.9e-26 2.3.1.128 K acetyltransferase
KFHDONED_01141 1.3e-38 2.3.1.128 K acetyltransferase
KFHDONED_01142 2.1e-257 gtf2 M A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1
KFHDONED_01143 4.9e-295 gtf1 2.4.1.52 GT4 M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
KFHDONED_01144 2.9e-229 thiI 2.8.1.4 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KFHDONED_01145 6.1e-213 iscS2 2.8.1.7 E Cysteine sulfinate desulfinase cysteine desulfurase and related enzymes
KFHDONED_01147 3.1e-242 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
KFHDONED_01148 1.4e-261 gor 1.8.1.7 C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KFHDONED_01149 3.3e-47 fruA 2.7.1.202 G phosphotransferase system
KFHDONED_01150 8.1e-139 fruA 2.7.1.202 G phosphotransferase system
KFHDONED_01151 7.8e-22 fruA 2.7.1.202 GT PTS system, Lactose/Cellobiose specific IIB subunit
KFHDONED_01152 2.1e-52 fruA 2.7.1.202 GT PTS system, Lactose/Cellobiose specific IIB subunit
KFHDONED_01153 7.1e-164 pfkB 2.7.1.11, 2.7.1.56 H Belongs to the carbohydrate kinase PfkB family. LacC subfamily
KFHDONED_01154 5.6e-114 fruR K transcriptional
KFHDONED_01155 7.6e-83 L Transposase
KFHDONED_01156 1.6e-206 rny D Endoribonuclease that initiates mRNA decay
KFHDONED_01157 5.8e-126 tnp L Transposase
KFHDONED_01158 4.7e-90 luxS 4.4.1.21 H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
KFHDONED_01159 3e-139 accA 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
KFHDONED_01160 3.5e-160 accD 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KFHDONED_01161 4.8e-257 accC 6.3.4.14, 6.4.1.2 I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
KFHDONED_01162 1.5e-71 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
KFHDONED_01163 2.9e-55 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
KFHDONED_01164 2.6e-233 fabF 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
KFHDONED_01165 1.3e-126 IQ reductase
KFHDONED_01166 8.5e-165 fabD 2.3.1.39 I Malonyl CoA-acyl carrier protein transacylase
KFHDONED_01167 3.4e-172 fabK 1.3.1.9 S 2-Nitropropane dioxygenase
KFHDONED_01168 3.3e-30 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
KFHDONED_01169 6.8e-173 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KFHDONED_01170 4e-72 marR K Transcriptional regulator, MarR family
KFHDONED_01171 2.4e-139 phaB 5.3.3.14, 5.3.3.18 I Belongs to the enoyl-CoA hydratase isomerase family
KFHDONED_01172 1.1e-113 S Haloacid dehalogenase-like hydrolase
KFHDONED_01173 2.4e-256 lysC 2.7.2.4 E Belongs to the aspartokinase family
KFHDONED_01174 2.3e-192 asnA 6.3.1.1 E aspartate--ammonia ligase
KFHDONED_01175 6.7e-259 rumA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KFHDONED_01176 7.3e-133 recX 2.4.1.337 GT4 S Regulatory protein RecX
KFHDONED_01177 7.8e-102 ygaC J Belongs to the UPF0374 family
KFHDONED_01178 2e-106 S Domain of unknown function (DUF1803)
KFHDONED_01179 1.3e-165 ppaC 3.6.1.1 C inorganic pyrophosphatase
KFHDONED_01187 2.3e-93 hpf J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KFHDONED_01188 3.4e-123 comFC S Competence protein
KFHDONED_01189 8.2e-254 comFA L Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
KFHDONED_01190 2.4e-110 yvyE 3.4.13.9 S YigZ family
KFHDONED_01191 2.8e-168 cysK 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
KFHDONED_01192 7.7e-13 acuB S IMP dehydrogenase activity
KFHDONED_01193 2.5e-63 acuB S CBS domain
KFHDONED_01194 2.1e-123 livF E COG0410 ABC-type branched-chain amino acid transport systems, ATPase component
KFHDONED_01195 8.2e-137 livG E COG0411 ABC-type branched-chain amino acid transport systems, ATPase component
KFHDONED_01196 1.8e-138 livM E Belongs to the binding-protein-dependent transport system permease family
KFHDONED_01197 1.9e-145 livH E Belongs to the binding-protein-dependent transport system permease family
KFHDONED_01198 1.1e-212 livJ E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component
KFHDONED_01199 7.1e-46 ylbG S UPF0298 protein
KFHDONED_01200 4.4e-74 ylbF S Belongs to the UPF0342 family
KFHDONED_01201 2.9e-105 clpP 3.4.21.92 OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
KFHDONED_01202 4.4e-112 upp 2.4.2.9 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KFHDONED_01203 4e-09 sacB 2.4.1.10, 2.4.1.9, 3.2.1.26 GH32,GH68 G Belongs to the glycosyl hydrolase 68 family
KFHDONED_01204 4.3e-222 malY 4.4.1.8 E COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
KFHDONED_01205 1.5e-200 metB 2.5.1.48, 4.4.1.8 E cystathionine
KFHDONED_01206 6e-89 pacL 3.6.3.8, 3.6.3.9 P cation transport ATPase
KFHDONED_01207 1.3e-282 ytgP S Membrane protein involved in the export of O-antigen and teichoic acid
KFHDONED_01208 1.4e-275 murE 6.3.2.13, 6.3.2.7 M to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KFHDONED_01209 1.4e-65 femA 2.3.2.10, 2.3.2.16, 2.3.2.17, 2.3.2.18 V protein involved in methicillin resistance
KFHDONED_01210 6.8e-159 femA 2.3.2.10, 2.3.2.16, 2.3.2.17, 2.3.2.18 V protein involved in methicillin resistance
KFHDONED_01212 3.4e-37 yvdD 3.2.2.10 L Belongs to the LOG family
KFHDONED_01213 3.6e-10 yvdD 3.2.2.10 S Belongs to the LOG family
KFHDONED_01214 1.7e-57 rbfA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KFHDONED_01215 0.0 infB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KFHDONED_01216 1.4e-41 ylxQ J ribosomal protein
KFHDONED_01217 1e-47 ylxR K Nucleic-acid-binding protein implicated in transcription termination
KFHDONED_01218 4.1e-212 nusA K Participates in both transcription termination and antitermination
KFHDONED_01219 3.9e-81 rimP S Required for maturation of 30S ribosomal subunits
KFHDONED_01220 2.8e-219 brpA K Transcriptional
KFHDONED_01221 3.2e-92 XK27_05885 2.3.1.82 M Acetyltransferase GNAT Family
KFHDONED_01222 1.4e-77 ydiB 2.7.1.221, 5.1.1.1 M ATPase or kinase
KFHDONED_01223 4.3e-248 pbuO S permease
KFHDONED_01224 1e-153 yitU 3.1.3.104 S hydrolases of the HAD superfamily
KFHDONED_01225 2.6e-140 XK27_00940 1.2.1.70, 3.5.1.9 S Metal-dependent hydrolase
KFHDONED_01226 1.1e-181 manL 2.7.1.191 G pts system
KFHDONED_01227 7.8e-117 manM G pts system
KFHDONED_01228 5.6e-169 manN G PTS system mannose fructose sorbose family IID component
KFHDONED_01229 6.5e-63 manO S protein conserved in bacteria
KFHDONED_01230 1.3e-232 serS 6.1.1.11 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KFHDONED_01231 4.1e-30 L Integrase core domain protein
KFHDONED_01232 1.6e-12 yrdC 3.5.1.19 Q isochorismatase
KFHDONED_01234 2e-247 der 1.1.1.399, 1.1.1.95 S GTPase that plays an essential role in the late steps of ribosome biogenesis
KFHDONED_01235 4e-167 dnaI L Primosomal protein DnaI
KFHDONED_01236 5e-218 dnaB L Replication initiation and membrane attachment
KFHDONED_01237 2.8e-82 nrdR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KFHDONED_01238 9.1e-281 T PhoQ Sensor
KFHDONED_01239 1.8e-122 T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
KFHDONED_01240 4.7e-91 yceD K metal-binding, possibly nucleic acid-binding protein
KFHDONED_01241 1.1e-130 rsmG 2.1.1.170 J Ribosomal RNA small subunit methyltransferase G
KFHDONED_01242 1.4e-243 P COG0168 Trk-type K transport systems, membrane components
KFHDONED_01243 1.4e-121 ktrA P COG0569 K transport systems, NAD-binding component
KFHDONED_01244 1.8e-11 ulaG S L-ascorbate 6-phosphate lactonase
KFHDONED_01245 0.0 tkt 2.2.1.1 G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KFHDONED_01246 7.2e-147 cbiQ P cobalt transport
KFHDONED_01247 0.0 ykoD P abc transporter atp-binding protein
KFHDONED_01248 8e-94 S UPF0397 protein
KFHDONED_01249 8.8e-110 salL 2.5.1.63, 2.5.1.94 S S-adenosyl-l-methionine hydroxide adenosyltransferase
KFHDONED_01250 1.5e-32 salL 2.5.1.63, 2.5.1.94 F Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
KFHDONED_01251 1.3e-210 sstT E Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
KFHDONED_01252 3e-98 metI P ABC transporter (Permease
KFHDONED_01253 1.5e-189 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KFHDONED_01254 2.6e-64 dapE 3.5.1.18 E succinyl-diaminopimelate desuccinylase activity
KFHDONED_01255 1.4e-62 dapE 3.5.1.18 E succinyl-diaminopimelate desuccinylase activity
KFHDONED_01256 3.7e-87 dapE 3.5.1.18 E COG0624, acetylornithine deacetylase succinyl-diaminopimelate desuccinylase and related deacylases
KFHDONED_01257 3.7e-165 metQ M Belongs to the NlpA lipoprotein family
KFHDONED_01258 5.8e-152 ET amino acid transport
KFHDONED_01259 1.6e-131 cbiO P ABC transporter
KFHDONED_01260 1.7e-137 P cobalt transport protein
KFHDONED_01261 3.5e-177 cbiM P PDGLE domain
KFHDONED_01262 8.9e-161 ureD O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
KFHDONED_01263 9.5e-112 ureG KO Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
KFHDONED_01264 5.3e-130 ureF O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
KFHDONED_01265 6.6e-78 ureE O enzyme active site formation
KFHDONED_01266 0.0 ureC 3.5.1.5 E Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family
KFHDONED_01267 7.8e-54 ureB 3.5.1.5 E Belongs to the urease beta subunit family
KFHDONED_01268 7.6e-46 ureA 3.5.1.5 E Belongs to the urease gamma subunit family
KFHDONED_01269 6.8e-95 ureI S AmiS/UreI family transporter
KFHDONED_01270 3.5e-131 S Domain of unknown function (DUF4173)
KFHDONED_01271 7.4e-44 yhaI L Membrane
KFHDONED_01272 3.4e-68 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
KFHDONED_01273 1.8e-27 comA V protein secretion by the type I secretion system
KFHDONED_01274 5.3e-34 V protein secretion by the type I secretion system
KFHDONED_01275 1.1e-108 V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
KFHDONED_01276 1.9e-33 V protein secretion by the type I secretion system
KFHDONED_01277 3.3e-161 K sequence-specific DNA binding
KFHDONED_01278 4.1e-113 bcrC 3.6.1.27 I Membrane-associated phospholipid phosphatase
KFHDONED_01279 3e-88 ribU U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
KFHDONED_01280 6.1e-96 trmL 2.1.1.207 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
KFHDONED_01281 1.5e-247 trkA P Potassium transporter peripheral membrane component
KFHDONED_01282 1.2e-258 trkH P Cation transport protein
KFHDONED_01283 2.3e-40 yidD S Could be involved in insertion of integral membrane proteins into the membrane
KFHDONED_01284 1.6e-140 rluB 5.4.99.19, 5.4.99.21, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
KFHDONED_01285 4.3e-98 scpB D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KFHDONED_01286 2e-121 scpA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KFHDONED_01287 7.5e-138 xerD L tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site
KFHDONED_01288 2.7e-85 ykuL S CBS domain
KFHDONED_01289 3.5e-99 XK27_09740 S Phosphoesterase
KFHDONED_01290 3.2e-186 rdgB 3.6.1.66, 5.1.1.3 F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KFHDONED_01291 3.8e-148 murI 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
KFHDONED_01292 7.6e-36 yneF S UPF0154 protein
KFHDONED_01293 9.6e-92 K transcriptional regulator
KFHDONED_01294 2.8e-243 lysA 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
KFHDONED_01297 3.3e-97 ybhL S Belongs to the BI1 family
KFHDONED_01298 2.3e-92 XK27_09705 6.1.1.14 S HD superfamily hydrolase
KFHDONED_01299 6.4e-131 spoU 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KFHDONED_01300 1.2e-45 acyP 3.6.1.7 C Belongs to the acylphosphatase family
KFHDONED_01301 2.9e-165 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
KFHDONED_01302 1e-84 L Integrase core domain protein
KFHDONED_01304 1.6e-77 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
KFHDONED_01305 0.0 mltG ADL Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KFHDONED_01306 6.4e-47 XK27_09675 K -acetyltransferase
KFHDONED_01307 2.1e-21 XK27_09675 K -acetyltransferase
KFHDONED_01308 1.5e-255 mpl 6.3.2.4, 6.3.2.45, 6.3.2.8 M Belongs to the MurCDEF family
KFHDONED_01309 2.5e-23
KFHDONED_01310 0.0 snf 2.7.11.1 L Superfamily II DNA RNA helicases, SNF2 family'
KFHDONED_01311 5e-297 mapZ D Early cell division protein that marks the future cell division site and supports proper FtsZ ring positioning
KFHDONED_01312 1.5e-222 rlmL 2.1.1.173, 2.1.1.264 L Belongs to the methyltransferase superfamily
KFHDONED_01313 2.5e-50 gpsB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
KFHDONED_01314 6.8e-95 ypsA S Belongs to the UPF0398 family
KFHDONED_01315 2.5e-109 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
KFHDONED_01316 0.0 ponA 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
KFHDONED_01317 6e-260 pepC 3.4.22.40 E aminopeptidase
KFHDONED_01318 3.2e-77 yhaI L Membrane
KFHDONED_01319 2.1e-151 nadE 6.3.1.5 H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
KFHDONED_01320 2.8e-279 pncB 6.3.4.21 H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KFHDONED_01321 2.2e-142 S COG1073 Hydrolases of the alpha beta superfamily
KFHDONED_01322 7.4e-89 S thiolester hydrolase activity
KFHDONED_01323 7.6e-41 K transcriptional
KFHDONED_01324 0.0 leuS 6.1.1.4 J Belongs to the class-I aminoacyl-tRNA synthetase family
KFHDONED_01325 3.1e-136 glcR K transcriptional regulator (DeoR family)
KFHDONED_01326 1.1e-34 cof Q phosphatase activity
KFHDONED_01327 6e-55 cof Q phosphatase activity
KFHDONED_01328 7.9e-85 3.1.3.27, 3.1.3.4, 3.1.3.81, 3.6.1.27 I phosphatidate phosphatase activity
KFHDONED_01329 8.4e-96 nusG K Participates in transcription elongation, termination and antitermination
KFHDONED_01330 1.6e-24 secE U Belongs to the SecE SEC61-gamma family
KFHDONED_01331 3.3e-21 rpmG J Belongs to the bacterial ribosomal protein bL33 family
KFHDONED_01332 0.0 pbp2A 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
KFHDONED_01333 2.1e-165 rluA 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
KFHDONED_01334 2.7e-28 J TM2 domain
KFHDONED_01335 9.4e-44
KFHDONED_01338 1.4e-33 L Integrase core domain protein
KFHDONED_01339 1.9e-50 L transposition
KFHDONED_01340 1.2e-09 L Transposase
KFHDONED_01341 4.2e-46 L transposase activity
KFHDONED_01342 4.1e-287 groL O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
KFHDONED_01343 1.3e-42 groS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KFHDONED_01344 5.2e-142 cmpC S abc transporter atp-binding protein
KFHDONED_01345 0.0 WQ51_06230 S ABC transporter substrate binding protein
KFHDONED_01346 0.0 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
KFHDONED_01347 2.5e-231 rseP 3.4.21.107, 3.4.21.116 M zinc metalloprotease
KFHDONED_01348 1.7e-145 cdsA 2.7.7.41 S Belongs to the CDS family
KFHDONED_01349 1.1e-141 uppS 2.5.1.31 H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KFHDONED_01350 9.8e-50 yajC U protein transport
KFHDONED_01351 1.9e-127 yeeN K transcriptional regulatory protein
KFHDONED_01352 2.8e-257 pgi 5.3.1.9 G Belongs to the GPI family
KFHDONED_01353 6.3e-96 rgfB 3.1.3.90 L Endonuclease/Exonuclease/phosphatase family
KFHDONED_01354 1.2e-48 rgfB 3.1.3.90 L Endonuclease/Exonuclease/phosphatase family
KFHDONED_01355 1.4e-155 ptsG 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G pts system
KFHDONED_01356 1.7e-94 ptsG 2.7.1.199, 2.7.1.208, 2.7.1.211 G pts system
KFHDONED_01357 1.1e-27 ptsG 2.7.1.199, 2.7.1.208 G pts system
KFHDONED_01358 8.1e-163 mleP2 S Transporter, auxin efflux carrier (AEC) family protein
KFHDONED_01359 4.6e-130 adcB P ABC transporter (Permease
KFHDONED_01360 2.2e-136 adcC P ABC transporter, ATP-binding protein
KFHDONED_01361 3.1e-72 adcR K transcriptional
KFHDONED_01362 4.2e-223 EGP Major facilitator Superfamily
KFHDONED_01363 0.0 KLT serine threonine protein kinase
KFHDONED_01365 6e-128 K sequence-specific DNA binding
KFHDONED_01366 7.4e-183 dus J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KFHDONED_01367 1.9e-158 hslO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KFHDONED_01368 1.1e-10
KFHDONED_01370 3.3e-164 oppF P Belongs to the ABC transporter superfamily
KFHDONED_01371 1.4e-43 oppD P Belongs to the ABC transporter superfamily
KFHDONED_01372 2.8e-67 oppD P Belongs to the ABC transporter superfamily
KFHDONED_01373 2.5e-32 oppD P Belongs to the ABC transporter superfamily
KFHDONED_01374 3e-27 oppD P Belongs to the ABC transporter superfamily
KFHDONED_01375 7.7e-59 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
KFHDONED_01376 7e-46 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
KFHDONED_01377 1.4e-139 oppA E ABC transporter substrate-binding protein
KFHDONED_01378 2.7e-18 oppA E ABC transporter substrate-binding protein
KFHDONED_01379 2.2e-273 sufB O assembly protein SufB
KFHDONED_01380 8.6e-75 nifU C SUF system FeS assembly protein, NifU family
KFHDONED_01381 2.9e-237 sufS 2.8.1.7, 4.4.1.16 E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KFHDONED_01382 1.4e-234 sufD O assembly protein SufD
KFHDONED_01383 9.5e-144 sufC O ABC-type transport system involved in Fe-S cluster assembly, ATPase component
KFHDONED_01384 3.8e-186 tagO 2.7.8.33, 2.7.8.35 M transferase
KFHDONED_01385 5.2e-136 mecA NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
KFHDONED_01386 3.1e-153 uppP 3.6.1.27 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
KFHDONED_01387 1.5e-275 glnP P ABC transporter
KFHDONED_01388 1e-123 glnQ E abc transporter atp-binding protein
KFHDONED_01390 2.1e-92 V VanZ like family
KFHDONED_01391 9.2e-43 rpsO J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KFHDONED_01392 4.6e-200 yhjX P Major Facilitator
KFHDONED_01393 2.9e-111 fnr5 K Catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
KFHDONED_01394 3.3e-112 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
KFHDONED_01395 1.7e-237 ilvA 4.3.1.19 E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KFHDONED_01396 5.7e-45 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
KFHDONED_01397 1.9e-65 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
KFHDONED_01398 8.8e-28 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
KFHDONED_01399 2.3e-75 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
KFHDONED_01400 0.0 relA 2.7.6.5 KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KFHDONED_01401 1.1e-80 nrdI F Belongs to the NrdI family
KFHDONED_01402 4.1e-185 cpdB 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
KFHDONED_01403 3.5e-138 cpdB 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
KFHDONED_01404 1.1e-45 F nucleotide catabolic process
KFHDONED_01405 2.2e-134 rsmE 2.1.1.193 J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
KFHDONED_01406 9.1e-178 prmA J Ribosomal protein L11 methyltransferase
KFHDONED_01407 3.7e-81 mutT3 3.6.1.13, 3.6.1.55 L NUDIX domain
KFHDONED_01408 2.9e-84 XK27_03960 S Protein of unknown function (DUF3013)
KFHDONED_01409 7.6e-310 pyrG 6.3.4.2 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
KFHDONED_01410 4.8e-73 rpoE K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
KFHDONED_01411 4.9e-219 tig D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
KFHDONED_01412 1e-148 ykuT M mechanosensitive ion channel
KFHDONED_01413 1.6e-77 sigH K DNA-templated transcription, initiation
KFHDONED_01414 1.5e-83
KFHDONED_01415 4.2e-233 cfa 2.1.1.317, 2.1.1.79 M cyclopropane-fatty-acyl-phospholipid synthase
KFHDONED_01416 1.8e-56 amd 3.5.1.47 E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
KFHDONED_01417 9.9e-19 S Domain of unknown function (DUF4649)
KFHDONED_01418 2e-71 L Transposase
KFHDONED_01419 0.0 ftsK D Belongs to the FtsK SpoIIIE SftA family
KFHDONED_01420 2e-188 trxB1 1.18.1.2, 1.19.1.1 C Ferredoxin--NADP reductase
KFHDONED_01421 9.4e-135 trmD 2.1.1.228, 4.6.1.12 J Belongs to the RNA methyltransferase TrmD family
KFHDONED_01422 5.8e-94 rimM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KFHDONED_01425 2.2e-114 vraR K Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
KFHDONED_01426 5.8e-175 vraS 2.7.13.3 T Histidine kinase
KFHDONED_01427 3.7e-120 yvqF KT membrane
KFHDONED_01428 0.0 prkC 2.7.11.1 KLT serine threonine protein kinase
KFHDONED_01429 2e-132 stp 3.1.3.16 T phosphatase
KFHDONED_01430 4.4e-247 sun 2.1.1.176 J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KFHDONED_01431 2.5e-172 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KFHDONED_01432 0.0 priA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KFHDONED_01433 2.7e-46 rpoZ 2.7.7.6 K DNA-directed 5'-3' RNA polymerase activity
KFHDONED_01434 1.7e-111 gmk 2.7.4.8 F Essential for recycling GMP and indirectly, cGMP
KFHDONED_01435 9.7e-213 ftsY U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
KFHDONED_01436 1.8e-150 XK27_02985 S overlaps another CDS with the same product name
KFHDONED_01437 2e-146 supH S overlaps another CDS with the same product name
KFHDONED_01438 1.9e-62 yvoA_1 K Transcriptional
KFHDONED_01439 2.2e-120 skfE V abc transporter atp-binding protein
KFHDONED_01440 7.3e-133 V ATPase activity
KFHDONED_01441 4.3e-172 oppF P Belongs to the ABC transporter superfamily
KFHDONED_01442 2.2e-204 oppD P Belongs to the ABC transporter superfamily
KFHDONED_01443 4.9e-168 amiD P ABC transporter (Permease
KFHDONED_01444 7.1e-278 amiC P ABC transporter (Permease
KFHDONED_01445 6.4e-140 amiA E ABC transporter, substrate-binding protein, family 5
KFHDONED_01446 1.2e-155 amiA E ABC transporter, substrate-binding protein, family 5
KFHDONED_01447 1.2e-24 oppF P Belongs to the ABC transporter superfamily
KFHDONED_01448 2e-46 oppF P Belongs to the ABC transporter superfamily
KFHDONED_01449 6.9e-22 tatD L hydrolase, TatD family'
KFHDONED_01450 2.8e-216 oxlT P COG0477 Permeases of the major facilitator superfamily
KFHDONED_01451 4.1e-33 L Integrase core domain protein
KFHDONED_01452 9.6e-32 L transposition
KFHDONED_01453 5.1e-27 L transposition
KFHDONED_01454 2.8e-22 L transposase activity
KFHDONED_01455 3.3e-39 L transposase activity
KFHDONED_01456 1.4e-181 pta 2.3.1.8, 3.6.3.21 C phosphate acetyltransferase
KFHDONED_01457 9.8e-174 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 J Responsible for synthesis of pseudouridine from uracil
KFHDONED_01458 4e-153 nadK 2.7.1.23 H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KFHDONED_01459 1.5e-121 yjbM 2.7.6.5 S Gtp pyrophosphokinase
KFHDONED_01460 1.5e-103 yjbK S Adenylate cyclase
KFHDONED_01461 1.3e-70 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KFHDONED_01462 9.5e-92 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KFHDONED_01463 3.2e-206 iscS 2.8.1.7 E Cysteine desulfurase
KFHDONED_01464 3.1e-59 XK27_04120 S Putative amino acid metabolism
KFHDONED_01465 6.3e-117 rex K Modulates transcription in response to changes in cellular NADH NAD( ) redox state
KFHDONED_01466 2.3e-130 puuD T peptidase C26
KFHDONED_01467 6.2e-120 radC E Belongs to the UPF0758 family
KFHDONED_01468 0.0 rgpF M Rhamnan synthesis protein F
KFHDONED_01469 8.2e-196 rgpEc GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
KFHDONED_01470 8.7e-226 rgpD 3.6.3.38 P Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system
KFHDONED_01471 2.3e-142 rgpC GM Transport permease protein
KFHDONED_01472 2.2e-179 rgpB GT2 M Glycosyltransferase, group 2 family protein
KFHDONED_01473 1.3e-226 rgpA GT4 M Domain of unknown function (DUF1972)
KFHDONED_01474 4.8e-193 tagF 2.7.8.12 M Glycosyl transferase, family 2
KFHDONED_01475 1.8e-221 amrA S polysaccharide biosynthetic process
KFHDONED_01476 5.3e-48 XK27_09090 S Uncharacterized conserved protein (DUF2304)
KFHDONED_01477 3.4e-126 ycbB S Glycosyl transferase family 2
KFHDONED_01478 1.5e-160 rfbD 1.1.1.133, 5.1.3.13 M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
KFHDONED_01479 3.9e-243
KFHDONED_01480 1.6e-171 yfdH GT2 M COG0463, glycosyltransferases involved in cell wall biogenesis
KFHDONED_01481 6.3e-252 M Psort location CytoplasmicMembrane, score
KFHDONED_01482 1e-54 yitW K metal-sulfur cluster biosynthetic enzyme
KFHDONED_01483 8e-202 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
KFHDONED_01484 0.0 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
KFHDONED_01485 1.2e-19 rpsU J Belongs to the bacterial ribosomal protein bS21 family
KFHDONED_01486 5.5e-136 gltS ET Belongs to the bacterial solute-binding protein 3 family
KFHDONED_01487 3.4e-200 arcT 2.6.1.1 E Aminotransferase
KFHDONED_01488 1.6e-135 ET ABC transporter
KFHDONED_01489 2.8e-143 ET Belongs to the bacterial solute-binding protein 3 family
KFHDONED_01490 2.9e-84 mutT 3.6.1.55 F Nudix family
KFHDONED_01491 0.0 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
KFHDONED_01493 2.5e-56 V CAAX protease self-immunity
KFHDONED_01494 3.8e-31 S CAAX amino terminal protease family protein
KFHDONED_01495 0.0 glnP P ABC-type amino acid transport signal transduction systems periplasmic component domain
KFHDONED_01496 6e-137 glnQ 3.6.3.21 E abc transporter atp-binding protein
KFHDONED_01497 1.1e-16 XK27_00735
KFHDONED_01498 1.4e-248 obg S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KFHDONED_01500 2.1e-134 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
KFHDONED_01503 5.5e-65 paaI Q protein possibly involved in aromatic compounds catabolism
KFHDONED_01504 3e-37 ycaO O OsmC-like protein
KFHDONED_01505 6.5e-154 EG Permeases of the drug metabolite transporter (DMT) superfamily
KFHDONED_01507 1.3e-109 csn2 S CRISPR-associated protein (Cas_Csn2)
KFHDONED_01508 2.2e-54 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
KFHDONED_01509 1.5e-163 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
KFHDONED_01510 0.0 cas9 L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
KFHDONED_01511 4.8e-114 serB 3.1.3.3 E phosphoserine phosphatase
KFHDONED_01512 2.1e-305 ezrA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
KFHDONED_01513 0.0 gyrB 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KFHDONED_01514 3.7e-108 3.1.3.18 S IA, variant 1
KFHDONED_01515 2.2e-117 lrgB M effector of murein hydrolase
KFHDONED_01516 2.2e-55 lrgA S Effector of murein hydrolase LrgA
KFHDONED_01518 6.4e-60 arsC 1.20.4.1 P Belongs to the ArsC family
KFHDONED_01519 5.2e-65 ogt 2.1.1.63, 3.2.2.20 L methylated-DNA-[protein]-cysteine S-methyltransferase activity
KFHDONED_01520 7e-220 serA 1.1.1.399, 1.1.1.95 EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KFHDONED_01521 1.3e-104 wecD M Acetyltransferase (GNAT) domain
KFHDONED_01522 1.3e-209 serC 2.6.1.52 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
KFHDONED_01523 1.4e-116 GK ROK family
KFHDONED_01524 3.1e-71 gloA 4.4.1.5 E Lactoylglutathione lyase
KFHDONED_01525 1e-115 XK27_08050 O HflC and HflK could regulate a protease
KFHDONED_01527 2.3e-206 potD P spermidine putrescine ABC transporter
KFHDONED_01528 9.5e-133 potC P ABC-type spermidine putrescine transport system, permease component II
KFHDONED_01529 3.7e-140 potB P ABC-type spermidine putrescine transport system, permease component I
KFHDONED_01530 1.2e-213 potA 3.6.3.30, 3.6.3.31 P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
KFHDONED_01531 4.6e-171 murB 1.3.1.98 M cell wall formation
KFHDONED_01532 1.9e-86 folK 2.7.6.3, 4.1.2.25 H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KFHDONED_01533 1.2e-61 folB 1.13.11.81, 2.5.1.15, 2.7.6.3, 4.1.2.25, 5.1.99.8 H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KFHDONED_01534 1.3e-297 amy 3.2.1.1 GH13 G Belongs to the glycosyl hydrolase 13 family
KFHDONED_01535 4.5e-146 folP 2.5.1.15, 2.7.6.3 H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KFHDONED_01536 1e-99 folE 3.5.4.16 F gtp cyclohydrolase
KFHDONED_01537 0.0 ydaO E amino acid
KFHDONED_01538 5.5e-239 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
KFHDONED_01539 4.1e-37 ylqC L Belongs to the UPF0109 family
KFHDONED_01540 2.4e-43 rpsP J Belongs to the bacterial ribosomal protein bS16 family
KFHDONED_01541 6.9e-172 tehB 2.1.1.265 Q Methyltransferase
KFHDONED_01542 1e-156 xth 3.1.11.2 L exodeoxyribonuclease III
KFHDONED_01543 2.1e-74 S QueT transporter
KFHDONED_01544 1.3e-185 yegS 2.7.1.107 I Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
KFHDONED_01545 0.0 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KFHDONED_01546 1.3e-85 ccl S cog cog4708
KFHDONED_01547 7.4e-164 rbn E Belongs to the UPF0761 family
KFHDONED_01548 1.5e-166 map 3.4.11.18 E Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed
KFHDONED_01549 7.3e-231 ytoI K transcriptional regulator containing CBS domains
KFHDONED_01550 1.8e-98 XK27_07830 2.3.1.128 J Acetyltransferase GNAT Family
KFHDONED_01551 3.1e-234 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KFHDONED_01552 0.0 comEC S Competence protein ComEC
KFHDONED_01553 1.2e-97 comEA L COG1555 DNA uptake protein and related DNA-binding proteins
KFHDONED_01554 1.3e-142 plsC 2.3.1.51 I Acyltransferase
KFHDONED_01555 6.4e-80 nodB3 G polysaccharide deacetylase
KFHDONED_01556 6.6e-47 nodB3 G polysaccharide deacetylase
KFHDONED_01557 1.2e-137 yabB 2.1.1.223 L Methyltransferase
KFHDONED_01558 1e-41 yazA L endonuclease containing a URI domain
KFHDONED_01559 4.6e-251 cshA 3.6.4.13 JKL DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
KFHDONED_01560 2.3e-154 corA P CorA-like protein
KFHDONED_01561 2.5e-62 yjqA S Bacterial PH domain
KFHDONED_01562 3.6e-97 thiT S Thiamine transporter
KFHDONED_01563 3.6e-157 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
KFHDONED_01564 4.4e-198 yjbB G Permeases of the major facilitator superfamily
KFHDONED_01565 3.1e-300 prfC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KFHDONED_01566 1.1e-121 ywaF S Integral membrane protein (intg_mem_TP0381)
KFHDONED_01567 1.5e-258 murF 6.3.2.10 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
KFHDONED_01569 1.1e-155 cjaA ET ABC transporter substrate-binding protein
KFHDONED_01570 4e-136 glnQ 3.6.3.21 E abc transporter atp-binding protein
KFHDONED_01571 3.5e-115 P ABC transporter (Permease
KFHDONED_01572 5.1e-114 papP P ABC transporter (Permease
KFHDONED_01573 6.4e-193 ddl 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
KFHDONED_01574 4.7e-31 copZ 2.7.7.77 P Heavy metal-associated domain protein
KFHDONED_01575 0.0 copA 3.6.3.54 P P-type ATPase
KFHDONED_01576 1.6e-73 copY K Copper transport repressor, CopY TcrY family
KFHDONED_01577 2.1e-143 trpA 4.2.1.20 E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
KFHDONED_01578 1.1e-228 trpB 4.2.1.20, 5.3.1.24 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
KFHDONED_01579 1.2e-100 trpF 4.1.1.48, 4.2.1.160, 4.2.1.20, 5.3.1.24 E belongs to the TrpF family
KFHDONED_01580 4.2e-133 trpC 4.1.1.48, 5.3.1.24 E Belongs to the TrpC family
KFHDONED_01581 9.6e-178 trpD 2.4.2.18, 4.1.3.27 F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KFHDONED_01582 2.3e-104 trpG 2.4.2.18, 2.6.1.85, 4.1.3.27 EH anthranilate
KFHDONED_01583 7.4e-258 trpE 4.1.3.27 EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KFHDONED_01584 6.2e-42 pchB 2.5.1.19, 4.2.1.10, 4.2.99.21, 5.4.99.5 E Chorismate mutase
KFHDONED_01585 3.2e-56
KFHDONED_01586 0.0 ctpE P E1-E2 ATPase
KFHDONED_01587 6.1e-27
KFHDONED_01588 1.2e-43 yaaK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KFHDONED_01589 5.1e-47 L transposase activity
KFHDONED_01590 3.7e-67 K transcriptional regulator, MerR family
KFHDONED_01591 1.3e-105 dnaQ 2.7.7.7 L DNA polymerase III
KFHDONED_01592 9.1e-42 WQ51_02910 S Protein of unknown function, DUF536
KFHDONED_01593 1.1e-62 XK27_02560 S cog cog2151
KFHDONED_01594 0.0 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
KFHDONED_01595 2.9e-226 ytfP S Flavoprotein
KFHDONED_01597 3.1e-121 trmB 2.1.1.297, 2.1.1.33 J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
KFHDONED_01598 1.2e-151 ytmP 2.7.1.89 M Phosphotransferase
KFHDONED_01599 1.9e-181 ecsB U ABC transporter
KFHDONED_01600 2.3e-133 ecsA V abc transporter atp-binding protein
KFHDONED_01601 1e-72 hit FG Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
KFHDONED_01602 1.3e-10
KFHDONED_01604 4.7e-106
KFHDONED_01606 5.2e-150 L Transposase
KFHDONED_01607 4.8e-54 L Transposase
KFHDONED_01608 0.0 clpL O ATP-dependent Clp protease ATP-binding subunit
KFHDONED_01609 4.5e-205 ylbM S Belongs to the UPF0348 family
KFHDONED_01610 2e-140 yqeM Q Methyltransferase domain protein
KFHDONED_01611 6e-58 rsfS J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
KFHDONED_01612 1.4e-107 nadD 2.7.6.3, 2.7.7.18 H HD superfamily hydrolase involved in NAD metabolism
KFHDONED_01613 4.1e-118 nadD 2.7.7.18, 3.6.1.55 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KFHDONED_01614 3.5e-49 yhbY J RNA-binding protein
KFHDONED_01615 1.7e-215 yqeH S in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis
KFHDONED_01616 1.8e-98 yqeG S hydrolase of the HAD superfamily
KFHDONED_01617 6.7e-154 yicL EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
KFHDONED_01618 1.4e-65
KFHDONED_01619 7.8e-274 gatB 6.1.1.12, 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KFHDONED_01620 4.5e-269 gatA 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
KFHDONED_01621 1.4e-47 gatC 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KFHDONED_01622 4.4e-25 2.4.1.52 GT4 M transferase activity, transferring glycosyl groups
KFHDONED_01623 7.4e-32 M lipopolysaccharide 3-alpha-galactosyltransferase activity
KFHDONED_01624 1.3e-254 ascB 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
KFHDONED_01625 7.9e-96 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KFHDONED_01626 8.1e-154 hlpA M Belongs to the NlpA lipoprotein family
KFHDONED_01627 3.4e-100 pncA Q isochorismatase
KFHDONED_01628 1.2e-140 codY K DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
KFHDONED_01629 6.2e-240 alaA 2.6.1.2, 2.6.1.66 E Aminotransferase
KFHDONED_01630 1.5e-74 XK27_03180 T universal stress protein
KFHDONED_01633 4.6e-238 L Transposase
KFHDONED_01634 2e-157 pflA 1.97.1.4 C Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KFHDONED_01635 9.9e-239 hlyX S COG1253 Hemolysins and related proteins containing CBS domains
KFHDONED_01636 2.4e-144 modF 3.6.3.21, 3.6.3.34 P abc transporter atp-binding protein
KFHDONED_01637 0.0 yjcE P NhaP-type Na H and K H antiporters
KFHDONED_01639 1.4e-98 ytqB 2.1.1.176 J (SAM)-dependent
KFHDONED_01640 8.4e-184 yhcC S radical SAM protein
KFHDONED_01641 8.4e-196 ylbL T Belongs to the peptidase S16 family
KFHDONED_01642 7.8e-88 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KFHDONED_01643 2.5e-92 rsmD 2.1.1.171 L Methyltransferase
KFHDONED_01644 1.9e-172 trxB 1.8.1.9 C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
KFHDONED_01645 6.1e-08 S Protein of unknown function (DUF4059)
KFHDONED_01646 3.4e-132 tcyN 3.6.3.21 E abc transporter atp-binding protein
KFHDONED_01647 1e-162 yxeN P ABC transporter (Permease
KFHDONED_01648 1.5e-152 yxeM ET ABC-type amino acid transport signal transduction systems, periplasmic component domain
KFHDONED_01650 1.7e-204 dinB 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KFHDONED_01651 0.0 pflB 2.3.1.54 C formate acetyltransferase'
KFHDONED_01652 2.2e-122 cah 4.2.1.1 P carbonic anhydrase
KFHDONED_01653 1.3e-84 yjcF S COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
KFHDONED_01654 5e-47 hsdS_1 3.1.21.3 V type I restriction modification DNA specificity domain
KFHDONED_01655 6.6e-47 D nuclear chromosome segregation
KFHDONED_01656 1.9e-35 D nuclear chromosome segregation
KFHDONED_01657 2.9e-81 L DNA integration
KFHDONED_01658 2.8e-120 XK27_05540 S Gram-negative-bacterium-type cell wall biogenesis
KFHDONED_01659 5.8e-127 ybbM S transport system, permease component
KFHDONED_01660 8e-117 ybbL S abc transporter atp-binding protein
KFHDONED_01661 4.5e-185 ampC V COG1680 Beta-lactamase class C and other penicillin binding proteins
KFHDONED_01662 4.6e-140 cppA E CppA N-terminal
KFHDONED_01663 1.1e-43 V CAAX protease self-immunity
KFHDONED_01664 6.8e-164 gla U Belongs to the MIP aquaporin (TC 1.A.8) family
KFHDONED_01665 0.0 pepX 3.4.14.11 E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline
KFHDONED_01667 2.4e-87 L Transposase
KFHDONED_01668 1.2e-165 L integrase core domain
KFHDONED_01671 1.5e-222 L Transposase
KFHDONED_01672 3.5e-152 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
KFHDONED_01674 0.0 mdlB V abc transporter atp-binding protein
KFHDONED_01675 0.0 mdlA V abc transporter atp-binding protein
KFHDONED_01677 5e-93 XK27_09885 V Glycopeptide antibiotics resistance protein
KFHDONED_01678 7.9e-224 rlmN 2.1.1.192 J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
KFHDONED_01679 2.4e-66 yutD J protein conserved in bacteria
KFHDONED_01680 9.6e-269 yunD 3.1.3.5 F Belongs to the 5'-nucleotidase family
KFHDONED_01682 3.2e-221 cshB 3.6.4.13 JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
KFHDONED_01683 6.3e-185 mraY 2.7.8.13 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KFHDONED_01684 0.0 ftsI 3.4.16.4 M penicillin-binding protein
KFHDONED_01685 4.3e-47 ftsL D cell division protein FtsL
KFHDONED_01686 3.9e-173 rsmH 2.1.1.199 J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
KFHDONED_01687 5.8e-159
KFHDONED_01688 5.8e-225 proA 1.2.1.41 E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KFHDONED_01689 4.4e-141 proB 2.7.2.11 E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KFHDONED_01690 6.7e-134 XK27_00765
KFHDONED_01691 1e-134 XK27_00765
KFHDONED_01692 7.1e-130 ecsA_2 V abc transporter atp-binding protein
KFHDONED_01693 2.1e-101 S Protein of unknown function (DUF554)
KFHDONED_01694 3.1e-10 S Protein of unknown function (DUF554)
KFHDONED_01695 1.4e-75 L transposase activity
KFHDONED_01696 1.6e-133 L Transposase and inactivated derivatives
KFHDONED_01697 0.0 addA 3.6.4.12 L ATP-dependent helicase nuclease subunit A
KFHDONED_01698 0.0 rexB 3.1.21.3, 3.6.4.12 L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
KFHDONED_01699 3.4e-57 liaI S membrane
KFHDONED_01700 5.4e-10 XK27_02470 K LytTr DNA-binding domain protein
KFHDONED_01701 8.5e-68 KT response to antibiotic
KFHDONED_01702 3.5e-17 KT response to antibiotic
KFHDONED_01703 1.6e-40 yebC M Membrane
KFHDONED_01704 2.4e-31 yebC M Membrane
KFHDONED_01705 2.9e-18 yebC M Membrane
KFHDONED_01706 3.6e-260 XK27_03190 5.2.1.8 S hydrolases of the HAD superfamily
KFHDONED_01707 3.2e-172 ansA 3.5.1.1 EJ COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D
KFHDONED_01708 0.0 recG 3.6.4.12 L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KFHDONED_01709 2e-184 alr 5.1.1.1, 5.1.1.5 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KFHDONED_01710 4.1e-62 acpS 2.7.6.3, 2.7.8.7, 5.1.1.1 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
KFHDONED_01711 1.1e-197 aroF 2.5.1.54 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KFHDONED_01712 2.9e-198 aroF 2.5.1.54 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KFHDONED_01713 0.0 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
KFHDONED_01715 6.7e-189 manA 5.3.1.8 G mannose-6-phosphate isomerase
KFHDONED_01716 4.1e-172 scrK 2.7.1.2, 2.7.1.4 GK Fructokinase
KFHDONED_01717 0.0 scrA 2.7.1.208, 2.7.1.211 G pts system
KFHDONED_01718 4.1e-291 scrB 3.2.1.26 GH32 G invertase
KFHDONED_01719 5.4e-178 scrR K Transcriptional
KFHDONED_01720 2.1e-73 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KFHDONED_01721 3.4e-62 yqhY S protein conserved in bacteria
KFHDONED_01722 1.2e-97 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KFHDONED_01723 3.7e-84 comEB 3.5.4.12 F ComE operon protein 2
KFHDONED_01724 2.5e-192 pepP 3.4.11.9, 3.4.13.9 E Belongs to the peptidase M24B family
KFHDONED_01727 1.1e-09 V 'abc transporter, ATP-binding protein
KFHDONED_01728 3.2e-20 V 'abc transporter, ATP-binding protein
KFHDONED_01729 2.4e-60 V 'abc transporter, ATP-binding protein
KFHDONED_01732 0.0 uvrA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KFHDONED_01733 2e-169 corA P COG0598 Mg2 and Co2 transporters
KFHDONED_01734 3.1e-124 XK27_01040 S Pfam PF06570
KFHDONED_01736 9.7e-36 rpsR J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KFHDONED_01737 2.7e-91 ssb L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
KFHDONED_01738 3.9e-47 rpsF J Binds together with S18 to 16S ribosomal RNA
KFHDONED_01739 2.8e-41 XK27_05745
KFHDONED_01740 4.2e-230 mutY L A G-specific adenine glycosylase
KFHDONED_01745 0.0 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KFHDONED_01746 0.0 mutS2 L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
KFHDONED_01747 1e-93 cvpA S toxin biosynthetic process
KFHDONED_01748 2.3e-13 zapA D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
KFHDONED_01749 4.7e-160 rnhC 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KFHDONED_01750 1.3e-113 lepB 3.4.21.89 U Belongs to the peptidase S26 family
KFHDONED_01751 0.0 recD2 3.1.11.5 L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
KFHDONED_01752 8.8e-48 azlD E branched-chain amino acid
KFHDONED_01753 1.2e-115 azlC E AzlC protein
KFHDONED_01754 5.7e-186 tsaD 2.3.1.234 O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KFHDONED_01755 1.3e-73 rimI 2.3.1.128 K This enzyme acetylates the N-terminal alanine of ribosomal protein S18
KFHDONED_01756 5.6e-121 yeaZ 2.3.1.234 O COG1214, inactive homolog of metal-dependent proteases
KFHDONED_01757 2.5e-33 ykzG S Belongs to the UPF0356 family
KFHDONED_01758 0.0 rnjA S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KFHDONED_01759 1.5e-263 glnA 6.3.1.2 E glutamine synthetase
KFHDONED_01760 8.5e-63 glnR K Transcriptional regulator
KFHDONED_01761 1.3e-87 S Fusaric acid resistance protein-like
KFHDONED_01762 2.5e-12
KFHDONED_01763 5e-20 L Transposase
KFHDONED_01764 3.4e-222 pgk 2.7.2.3, 5.3.1.1 F Belongs to the phosphoglycerate kinase family
KFHDONED_01765 7.9e-41 L Transposase
KFHDONED_01766 5.7e-43 L transposase activity
KFHDONED_01767 1.3e-22 L Transposase
KFHDONED_01768 1e-54 L transposition
KFHDONED_01769 8.5e-88 L Integrase core domain protein
KFHDONED_01770 2.4e-189 gap 1.2.1.12 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
KFHDONED_01771 0.0 fusA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KFHDONED_01772 6.7e-81 rpsG J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
KFHDONED_01773 2.3e-69 rpsL J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KFHDONED_01774 1.1e-142 purR 2.4.2.7 F operon repressor
KFHDONED_01775 9e-178 cbf S 3'-5' exoribonuclease yhaM
KFHDONED_01776 6.9e-173 rmuC S RmuC domain protein
KFHDONED_01777 3.1e-118 thiN 2.7.6.2 H thiamine pyrophosphokinase
KFHDONED_01778 3e-119 rpe 5.1.3.1 G Belongs to the ribulose-phosphate 3-epimerase family
KFHDONED_01779 3.8e-162 rsgA 3.1.3.100 G One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
KFHDONED_01781 5.8e-155 ksgA 2.1.1.182 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
KFHDONED_01782 8.4e-99 rnmV 3.1.26.8 J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KFHDONED_01783 2.7e-143 tatD L Hydrolase, tatd
KFHDONED_01784 1.5e-74 yccU S CoA-binding protein
KFHDONED_01785 4.8e-51 trxA O Belongs to the thioredoxin family
KFHDONED_01786 1.9e-141 S Macro domain protein
KFHDONED_01787 9.1e-10 L thioesterase
KFHDONED_01788 3.2e-53 bta 1.8.1.8 CO cell redox homeostasis
KFHDONED_01792 1.7e-226 tgt 2.4.2.29 F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
KFHDONED_01793 1.1e-83 L Transposase
KFHDONED_01794 1e-13 rpmH J Ribosomal protein L34
KFHDONED_01795 8.2e-172 jag S RNA-binding protein
KFHDONED_01796 4.9e-140 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
KFHDONED_01797 1.2e-55 rnpA 3.1.26.5 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
KFHDONED_01798 3e-262 argH 4.3.2.1 E Argininosuccinate lyase
KFHDONED_01799 2e-230 argG 6.3.4.5 E Belongs to the argininosuccinate synthase family. Type 1 subfamily
KFHDONED_01800 2.1e-282 gltX 6.1.1.17, 6.1.1.24 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KFHDONED_01801 9.5e-63 amiA E transmembrane transport
KFHDONED_01802 4.2e-74 amiA E transmembrane transport
KFHDONED_01803 4.8e-120 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
KFHDONED_01804 3.7e-70 rplK J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KFHDONED_01805 9.2e-51 S Protein of unknown function (DUF3397)
KFHDONED_01806 2e-88 cah 4.2.1.1 P Reversible hydration of carbon dioxide
KFHDONED_01807 6.5e-37 WQ51_05710 S Mitochondrial biogenesis AIM24
KFHDONED_01808 8.1e-12 WQ51_05710 S Mitochondrial biogenesis AIM24
KFHDONED_01809 4.8e-227 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KFHDONED_01810 1.1e-80 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
KFHDONED_01811 4.7e-20 XK27_09620 S FMN reductase (NADPH) activity
KFHDONED_01812 6.8e-75 XK27_09620 S reductase
KFHDONED_01813 8.4e-60 XK27_09615 C reductase
KFHDONED_01814 1.5e-141 XK27_09615 C reductase
KFHDONED_01815 2.3e-52 fnt P Formate nitrite transporter
KFHDONED_01816 9.6e-49 fnt P Formate nitrite transporter
KFHDONED_01817 1.1e-48 XK27_08585 S Psort location CytoplasmicMembrane, score
KFHDONED_01818 7.6e-186 gpsA 1.1.1.94 I Glycerol-3-phosphate dehydrogenase
KFHDONED_01819 5.1e-170 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
KFHDONED_01820 5.2e-119 gluP 3.4.21.105 O membrane protein (homolog of Drosophila rhomboid)
KFHDONED_01821 3.5e-94 ygfA 6.3.3.2 H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KFHDONED_01822 1e-220 hipO 3.5.1.47 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
KFHDONED_01823 8.1e-59 dapD 2.3.1.117, 2.3.1.89 E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
KFHDONED_01824 2.7e-48 S glycolate biosynthetic process
KFHDONED_01825 2.6e-64 S phosphatase activity
KFHDONED_01826 2e-157 rrmA 2.1.1.187 Q methyltransferase
KFHDONED_01828 4.6e-91 tadA 3.5.4.1, 3.5.4.33 FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
KFHDONED_01829 5.1e-66 ssb_2 L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
KFHDONED_01830 6.4e-37 yeeD O sulfur carrier activity
KFHDONED_01831 1.5e-186 yeeE S Sulphur transport
KFHDONED_01832 7.9e-114 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
KFHDONED_01833 2.1e-54 ytpP 2.7.1.180, 5.3.4.1 CO Thioredoxin
KFHDONED_01834 1.8e-09 S Domain of unknown function (DUF4651)
KFHDONED_01835 2e-205 pepA 3.4.11.7 G COG1363 Cellulase M and related proteins
KFHDONED_01836 3.9e-131 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KFHDONED_01837 1.6e-109 S CAAX amino terminal protease family protein
KFHDONED_01839 9.4e-53 V CAAX protease self-immunity
KFHDONED_01840 8.8e-27 lanR K sequence-specific DNA binding
KFHDONED_01841 2.6e-222 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KFHDONED_01842 1.3e-176 ytxK 2.1.1.72 L DNA methylase
KFHDONED_01843 1.2e-12 comGF U Putative Competence protein ComGF
KFHDONED_01844 4.5e-71 comGF U Competence protein ComGF
KFHDONED_01845 1.4e-15 NU Type II secretory pathway pseudopilin
KFHDONED_01846 1.8e-57 cglD NU Competence protein
KFHDONED_01847 8.5e-43 comGC U Required for transformation and DNA binding
KFHDONED_01848 9.2e-153 cglB NU type II secretion system
KFHDONED_01849 2.2e-176 comGA NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KFHDONED_01850 1.1e-67 S cog cog4699
KFHDONED_01851 0.0 rpoC 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KFHDONED_01852 0.0 rpoB 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KFHDONED_01853 0.0 pbp1B 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
KFHDONED_01854 1.6e-238 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KFHDONED_01855 1.6e-196 ilvC 1.1.1.86 H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KFHDONED_01856 7.7e-77 ilvN 2.2.1.6 E Acetolactate synthase
KFHDONED_01857 0.0 ilvB 2.2.1.6 EH Acetolactate synthase
KFHDONED_01858 2.2e-246 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
KFHDONED_01859 5.5e-66 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
KFHDONED_01860 7.6e-305 yloV S kinase related to dihydroxyacetone kinase
KFHDONED_01861 1.8e-57 asp S cog cog1302
KFHDONED_01862 7.1e-226 norM V Mate efflux family protein
KFHDONED_01863 1.1e-278 thrC 4.2.3.1 E Threonine synthase
KFHDONED_01864 7.2e-65 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
KFHDONED_01865 8e-35 adhE 1.1.1.1, 1.2.1.10 C hydroxyacid-oxoacid transhydrogenase activity
KFHDONED_01866 4.6e-67 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
KFHDONED_01867 1.2e-133 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
KFHDONED_01868 2.1e-52 adhE 1.1.1.1, 1.2.1.10 C Dehydrogenase
KFHDONED_01869 0.0 pepO 3.4.24.71 O Peptidase family M13
KFHDONED_01870 3.3e-39 treC 3.2.1.93 GH13 G COG0366 Glycosidases
KFHDONED_01871 1.2e-69 treC 3.2.1.93 GH13 G COG0366 Glycosidases
KFHDONED_01872 1.7e-65 treC 3.2.1.93 GH13 G COG0366 Glycosidases
KFHDONED_01873 4.2e-11 treC 3.2.1.93 GH13 G COG0366 Glycosidases
KFHDONED_01874 8.3e-55 treB 2.7.1.201 G PTS System
KFHDONED_01875 5.8e-21 treR K DNA-binding transcription factor activity
KFHDONED_01876 2.5e-86 treR K trehalose operon
KFHDONED_01877 3.3e-95 ywlG S Belongs to the UPF0340 family
KFHDONED_01880 4.1e-33 L PFAM Integrase, catalytic core
KFHDONED_01881 3e-33 L PFAM Integrase, catalytic core
KFHDONED_01882 1.2e-71 L PFAM Integrase, catalytic core
KFHDONED_01883 5.3e-164 fba 4.1.2.13, 4.1.2.29 G aldolase
KFHDONED_01885 6e-58 6.3.2.2 H ergothioneine biosynthetic process
KFHDONED_01886 2.3e-18 6.3.2.2 H gamma-glutamylcysteine synthetase
KFHDONED_01887 1.2e-11 6.3.2.2 H gamma-glutamylcysteine synthetase
KFHDONED_01888 2.7e-13 L PFAM Integrase, catalytic core
KFHDONED_01889 1.5e-32 L PFAM Integrase, catalytic core
KFHDONED_01890 1.2e-71 L PFAM Integrase, catalytic core
KFHDONED_01891 3.3e-62 rplQ J ribosomal protein l17
KFHDONED_01892 4.8e-171 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KFHDONED_01893 9.6e-62 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KFHDONED_01894 4e-57 rpsM J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KFHDONED_01895 6e-15 rpmJ J Belongs to the bacterial ribosomal protein bL36 family
KFHDONED_01896 2.7e-32 infA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KFHDONED_01897 9.2e-121 adk 2.7.4.3 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
KFHDONED_01898 3.3e-231 secY U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
KFHDONED_01899 7.4e-58 rplO J binds to the 23S rRNA
KFHDONED_01900 2.5e-23 rpmD J ribosomal protein l30
KFHDONED_01901 1.7e-79 rpsE J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KFHDONED_01902 1.1e-56 rplR J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KFHDONED_01903 2.3e-93 rplF J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KFHDONED_01904 1.2e-67 rpsH J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KFHDONED_01905 1.5e-28 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KFHDONED_01906 1.2e-94 rplE J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KFHDONED_01907 1.1e-47 rplX J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KFHDONED_01908 1.1e-59 rplN J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KFHDONED_01909 2e-39 rpsQ J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KFHDONED_01910 2.7e-26 rpmC J Belongs to the universal ribosomal protein uL29 family
KFHDONED_01911 7.2e-71 rplP J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KFHDONED_01912 1e-116 rpsC J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KFHDONED_01913 7.3e-53 rplV J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KFHDONED_01914 8.3e-47 rpsS J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KFHDONED_01915 2.6e-152 rplB J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KFHDONED_01916 2.4e-44 rplW J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
KFHDONED_01917 5.7e-104 rplD J Forms part of the polypeptide exit tunnel
KFHDONED_01918 2.4e-110 rplC J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KFHDONED_01919 1.3e-48 rpsJ J Involved in the binding of tRNA to the ribosomes
KFHDONED_01920 3.9e-187 ruvB 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
KFHDONED_01921 0.0 XK27_09800 I Acyltransferase
KFHDONED_01922 1.7e-35 XK27_09805 S MORN repeat protein
KFHDONED_01923 1.8e-80 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KFHDONED_01924 4.1e-250 purA 6.3.4.4 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KFHDONED_01925 8.9e-95 adk 2.7.4.3 F topology modulation protein
KFHDONED_01927 2e-222 L Transposase
KFHDONED_01929 3.4e-155 Z012_04635 K sequence-specific DNA binding
KFHDONED_01930 0.0 KLT serine threonine protein kinase
KFHDONED_01931 2.1e-280 V ABC transporter
KFHDONED_01932 2.4e-13 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
KFHDONED_01933 3.7e-128 Z012_04635 K sequence-specific DNA binding
KFHDONED_01935 2.6e-109 C Radical SAM
KFHDONED_01936 3e-104 C Radical SAM
KFHDONED_01937 3.9e-287 V ABC transporter transmembrane region
KFHDONED_01938 1e-155 L Replication initiation factor
KFHDONED_01939 1.9e-18 S Domain of unknown function (DUF3173)
KFHDONED_01940 7.7e-216 int L Belongs to the 'phage' integrase family
KFHDONED_01942 2.6e-236 rarA L ATPase related to the helicase subunit of the Holliday junction resolvase
KFHDONED_01943 8.4e-27 rpmB J Belongs to the bacterial ribosomal protein bL28 family
KFHDONED_01944 2.2e-44 yrzL S Belongs to the UPF0297 family
KFHDONED_01945 9.5e-71 yqgF L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KFHDONED_01946 1.3e-45 yrzB S Belongs to the UPF0473 family
KFHDONED_01947 5.8e-297 ccs S the current gene model (or a revised gene model) may contain a frame shift
KFHDONED_01948 0.0 nrdD 1.1.98.6 F Ribonucleoside-triphosphate reductase
KFHDONED_01949 7.5e-14
KFHDONED_01950 3.4e-91 XK27_10930 K acetyltransferase
KFHDONED_01951 2.8e-116 nrdG 1.97.1.4 O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KFHDONED_01952 7.7e-146 yaaA S Belongs to the UPF0246 family
KFHDONED_01953 4.6e-166 XK27_01785 S cog cog1284
KFHDONED_01954 0.0 aspS 6.1.1.12 J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
KFHDONED_01956 1.2e-241 hisS 6.1.1.21 J histidyl-tRNA synthetase
KFHDONED_01957 1.8e-136 metE 2.1.1.14 E Methionine synthase
KFHDONED_01958 1.8e-30 metE 2.1.1.14 E Methionine synthase
KFHDONED_01959 2e-25 rpmF J Belongs to the bacterial ribosomal protein bL32 family
KFHDONED_01960 6.7e-19 rpmG J Belongs to the bacterial ribosomal protein bL33 family
KFHDONED_01961 1.4e-28
KFHDONED_01962 0.0 V Type II restriction enzyme, methylase subunits
KFHDONED_01963 1.8e-08 S Sigma-70, region 4
KFHDONED_01964 2.9e-35
KFHDONED_01965 1.6e-162 D COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins
KFHDONED_01966 2e-20
KFHDONED_01967 1.2e-82 S Plasmid replication protein
KFHDONED_01968 2.7e-20 S MerR HTH family regulatory protein
KFHDONED_01969 1.8e-184 sip L Belongs to the 'phage' integrase family
KFHDONED_01972 7.9e-47 yegS 2.7.1.107 I Diacylglycerol kinase
KFHDONED_01973 2.4e-52 yegS 2.7.1.107 I Diacylglycerol kinase
KFHDONED_01974 4.2e-96 S Hydrophobic domain protein
KFHDONED_01976 3.7e-27 S Membrane
KFHDONED_01977 1.2e-100
KFHDONED_01978 1.8e-23 S Small integral membrane protein
KFHDONED_01979 3.1e-85 M Protein conserved in bacteria
KFHDONED_01980 1.1e-11 K CsbD-like
KFHDONED_01981 2.4e-98 nudL L hydrolase
KFHDONED_01982 5.5e-08 nudL L hydrolase
KFHDONED_01983 4e-19 K negative regulation of transcription, DNA-templated
KFHDONED_01984 1.7e-23 K negative regulation of transcription, DNA-templated
KFHDONED_01986 1.2e-18 XK27_06920 S Protein of unknown function (DUF1700)
KFHDONED_01987 3.1e-108 S Putative adhesin
KFHDONED_01988 7.6e-157 XK27_06930 V domain protein
KFHDONED_01989 6.4e-96 XK27_06935 K transcriptional regulator
KFHDONED_01990 6.6e-52 ypaA S membrane
KFHDONED_01991 1.8e-08
KFHDONED_01992 9.8e-109 rpsD J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KFHDONED_01993 8.2e-48 veg S Biofilm formation stimulator VEG
KFHDONED_01994 1.5e-245 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
KFHDONED_01995 2e-69 rplI J binds to the 23S rRNA
KFHDONED_01996 0.0 yybT T signaling protein consisting of a modified GGDEF domain and a DHH domain
KFHDONED_01997 0.0 gidA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
KFHDONED_01998 1.5e-77 F NUDIX domain
KFHDONED_01999 1.1e-219 mnmA 2.8.1.13 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
KFHDONED_02000 0.0 S Bacterial membrane protein, YfhO
KFHDONED_02001 5e-61 isaA GH23 M Immunodominant staphylococcal antigen A
KFHDONED_02002 3.1e-93 lytE M LysM domain protein
KFHDONED_02003 2.2e-137 ecfT P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KFHDONED_02004 5.2e-153 ecfA2 3.6.3.55 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KFHDONED_02005 1.5e-152 ecfA1 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KFHDONED_02006 6.9e-90 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KFHDONED_02007 3.7e-138 ymfM S sequence-specific DNA binding
KFHDONED_02008 1.4e-242 ymfH S Peptidase M16
KFHDONED_02009 1.4e-234 ymfF S Peptidase M16
KFHDONED_02010 1.6e-45 yaaA S S4 domain protein YaaA
KFHDONED_02011 3.8e-204 recF L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KFHDONED_02012 3.3e-275 guaB 1.1.1.205 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
KFHDONED_02013 6.3e-193 trpS 6.1.1.2 J Tryptophanyl-tRNA synthetase
KFHDONED_02014 1.2e-152 yvjA S membrane
KFHDONED_02015 6.7e-306 ybiT S abc transporter atp-binding protein
KFHDONED_02016 0.0 XK27_10405 S Bacterial membrane protein YfhO
KFHDONED_02020 1.1e-119 yoaK S Psort location CytoplasmicMembrane, score
KFHDONED_02021 1.1e-86 rlmH 2.1.1.177 J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KFHDONED_02022 1.1e-196 htrA 3.4.21.107 O Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain'
KFHDONED_02023 8.5e-134 parB K Belongs to the ParB family

eggNOG-mapper v2 (Database: eggNOG v5.0, Jul. 2018 release)