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ORF_ID	e_value	Gene_name	EC_number	COGs	Description
CNGDEHKH_00001	1.3e-254	dnaA		L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CNGDEHKH_00002	4.4e-203	dnaN	2.7.7.7	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
CNGDEHKH_00003	1.2e-32	yaaA		S	S4 domain
CNGDEHKH_00004	1.6e-205	recF		L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CNGDEHKH_00005	7.3e-11	yaaB		S	Domain of unknown function (DUF370)
CNGDEHKH_00006	0.0	gyrB	5.99.1.3	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CNGDEHKH_00007	0.0	gyrA	5.99.1.3	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CNGDEHKH_00008	1.7e-196	M1-161		T	HD domain
CNGDEHKH_00009	4.3e-42			S	COG NOG14552 non supervised orthologous group
CNGDEHKH_00012	1.7e-41
CNGDEHKH_00013	3.9e-36	csfB		S	Inhibitor of sigma-G Gin
CNGDEHKH_00014	1.8e-289	adiA	4.1.1.17, 4.1.1.18, 4.1.1.19	E	Orn Lys Arg decarboxylase
CNGDEHKH_00015	2e-120	tmk	2.7.4.9	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CNGDEHKH_00016	9.8e-55	yaaQ		S	protein conserved in bacteria
CNGDEHKH_00017	1.8e-72	yaaR		S	protein conserved in bacteria
CNGDEHKH_00018	4.3e-186	holB	2.7.7.7	L	DNA polymerase III
CNGDEHKH_00019	1.7e-148	yaaT		S	stage 0 sporulation protein
CNGDEHKH_00020	4.5e-67	yabA		L	Involved in initiation control of chromosome replication
CNGDEHKH_00021	3.8e-139	yabB	2.1.1.223	S	Conserved hypothetical protein 95
CNGDEHKH_00022	1e-47	yazA		L	endonuclease containing a URI domain
CNGDEHKH_00023	2.7e-152	rsmI	2.1.1.198	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CNGDEHKH_00024	1.2e-56	abrB		K	COG2002 Regulators of stationary sporulation gene expression
CNGDEHKH_00025	0.0	metG	6.1.1.10	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CNGDEHKH_00026	3e-147	tatD		L	hydrolase, TatD
CNGDEHKH_00027	8.5e-105	rnmV	3.1.26.8	J	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CNGDEHKH_00028	2.3e-159	ksgA	2.1.1.182	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
CNGDEHKH_00029	8.7e-167	yabG		S	peptidase
CNGDEHKH_00030	2.4e-37	veg		S	protein conserved in bacteria
CNGDEHKH_00031	1.9e-33	sspF		S	DNA topological change
CNGDEHKH_00032	3.2e-161	ispE	2.1.1.182, 2.7.1.148	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CNGDEHKH_00033	6.4e-154	purR	2.4.2.22, 2.4.2.7	F	pur operon repressor
CNGDEHKH_00034	2.7e-61	yabJ	3.5.99.10	J	translation initiation inhibitor, yjgF family
CNGDEHKH_00035	3.6e-48	spoVG		D	Essential for sporulation. Interferes with or is a negative regulator of the pathway leading to asymmetric septation
CNGDEHKH_00037	3.7e-135			S	Psort location CytoplasmicMembrane, score
CNGDEHKH_00038	2.7e-82			L	Transposase
CNGDEHKH_00039	7.3e-45			L	Transposase, IS4 family protein
CNGDEHKH_00040	1.3e-21			S	Psort location CytoplasmicMembrane, score
CNGDEHKH_00041	2.9e-63			V	ABC transporter
CNGDEHKH_00042	2.9e-81
CNGDEHKH_00043	3.5e-247	glmU	2.3.1.157, 2.7.7.23	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CNGDEHKH_00044	4.3e-175	prs	2.7.6.1	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CNGDEHKH_00045	6.3e-111	ctc		J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CNGDEHKH_00046	9.3e-106	pth	3.1.1.29	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
CNGDEHKH_00047	1.7e-37	yabK		S	Peptide ABC transporter permease
CNGDEHKH_00048	0.0	mfd		L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CNGDEHKH_00049	1.8e-90	spoVT		K	stage V sporulation protein
CNGDEHKH_00050	3.1e-287	yabM		S	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
CNGDEHKH_00051	3.7e-196	mazG	3.6.1.66, 3.6.1.9	S	COG3956 Protein containing tetrapyrrole methyltransferase domain and MazG-like
CNGDEHKH_00052	1.1e-41	yabO		J	COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
CNGDEHKH_00053	4.7e-51	yabP		S	Sporulation protein YabP
CNGDEHKH_00054	3.7e-111	yabQ		S	spore cortex biosynthesis protein
CNGDEHKH_00055	1.9e-60	divIC		D	Septum formation initiator
CNGDEHKH_00056	2.8e-54	yabR		J	RNA binding protein (contains ribosomal protein S1 domain)
CNGDEHKH_00058	0.0	spoIIE	3.1.3.16, 3.1.3.3	KT	stage II sporulation protein E
CNGDEHKH_00059	4.3e-119	yabS		S	protein containing a von Willebrand factor type A (vWA) domain
CNGDEHKH_00060	2e-167			KLT	serine threonine protein kinase
CNGDEHKH_00061	3.1e-278	tilS	2.4.2.8, 6.3.4.19	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
CNGDEHKH_00062	1.1e-95	hpt	2.4.2.8, 6.3.4.19	F	Belongs to the purine pyrimidine phosphoribosyltransferase family
CNGDEHKH_00063	0.0	ftsH		O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CNGDEHKH_00064	1.7e-159	coaX	2.7.1.33	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CNGDEHKH_00065	3e-159	hslO		O	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CNGDEHKH_00066	2.6e-169	cysK	2.5.1.47	E	Belongs to the cysteine synthase cystathionine beta- synthase family
CNGDEHKH_00067	8.3e-159	folP	2.5.1.15, 2.7.6.3	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CNGDEHKH_00068	3.5e-61	folB	1.13.11.81, 2.5.1.15, 2.7.6.3, 4.1.2.25, 5.1.99.8	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CNGDEHKH_00069	2.1e-96	folK	1.13.11.81, 2.5.1.15, 2.7.6.3, 3.5.4.16, 4.1.2.25, 5.1.99.8	H	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CNGDEHKH_00070	3.5e-285	lysS	6.1.1.6	J	Belongs to the class-II aminoacyl-tRNA synthetase family
CNGDEHKH_00071	4.3e-42			S	COG NOG14552 non supervised orthologous group
CNGDEHKH_00072	5.3e-43
CNGDEHKH_00075	1.6e-08
CNGDEHKH_00076	4e-08
CNGDEHKH_00080	4.3e-42			S	COG NOG14552 non supervised orthologous group
CNGDEHKH_00081	1.6e-42
CNGDEHKH_00082	1.3e-181	yaaC		S	YaaC-like Protein
CNGDEHKH_00083	1.5e-272	guaB	1.1.1.205	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
CNGDEHKH_00084	6.5e-251	dacA	3.4.16.4	M	Belongs to the peptidase S11 family
CNGDEHKH_00085	1.6e-157	pdxS	4.3.3.6	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CNGDEHKH_00086	1.3e-102	pdxT	4.3.3.6	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CNGDEHKH_00087	2.9e-211	serS	6.1.1.11	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CNGDEHKH_00088	3e-248			L	PFAM Transposase, IS4-like
CNGDEHKH_00089	2.9e-09
CNGDEHKH_00090	3.3e-126	dck	2.7.1.113, 2.7.1.74, 2.7.1.76	F	Deoxycytidine kinase
CNGDEHKH_00091	2.9e-119	dgk	2.7.1.113, 2.7.1.74, 2.7.1.76	F	Deoxyguanosine kinase
CNGDEHKH_00092	8.5e-229	yaaH		M	Glycoside Hydrolase Family
CNGDEHKH_00093	2.1e-88	tadA	3.5.4.1, 3.5.4.33	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
CNGDEHKH_00094	5.3e-306	dnaX	2.7.7.7	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CNGDEHKH_00095	5e-35	yaaK		S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CNGDEHKH_00096	1.5e-109	recR		L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CNGDEHKH_00097	3.4e-08	yaaL		S	Protein of unknown function (DUF2508)
CNGDEHKH_00098	4.8e-36	bofA		S	Sigma-K factor-processing regulatory protein BofA
CNGDEHKH_00100	1.6e-210			L	Transposase
CNGDEHKH_00101	4.3e-42			S	COG NOG14552 non supervised orthologous group
CNGDEHKH_00104	5.3e-43
CNGDEHKH_00105	5.4e-75	ctsR		K	Belongs to the CtsR family
CNGDEHKH_00106	1.3e-99	mcsA	2.7.14.1	S	protein with conserved CXXC pairs
CNGDEHKH_00107	2.1e-191	mcsB	2.7.14.1, 2.7.3.2, 2.7.3.3	E	Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity
CNGDEHKH_00108	0.0	clpC		O	Belongs to the ClpA ClpB family
CNGDEHKH_00109	2.9e-254	radA		O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CNGDEHKH_00110	6.9e-198	yacL		S	COG4956 Integral membrane protein (PIN domain superfamily)
CNGDEHKH_00111	7.5e-118	ispD	2.7.7.60, 4.6.1.12	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)
CNGDEHKH_00112	2.1e-82	ispF	2.1.1.228, 2.7.7.60, 4.6.1.12	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)

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