ORF_ID e_value Gene_name EC_number CAZy COGs Description
HPPHLOHB_00001 1.3e-235 dnaA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HPPHLOHB_00002 6.1e-205 dnaN 2.7.7.7 L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
HPPHLOHB_00003 2.4e-33 yaaA S S4 domain
HPPHLOHB_00004 1.4e-206 recF L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HPPHLOHB_00005 1.8e-37 yaaB S Domain of unknown function (DUF370)
HPPHLOHB_00006 0.0 gyrB 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPPHLOHB_00007 0.0 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPPHLOHB_00008 3.4e-39 S COG NOG14552 non supervised orthologous group
HPPHLOHB_00011 2.7e-182 yaaC S YaaC-like Protein
HPPHLOHB_00012 1.8e-273 guaB 1.1.1.205 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
HPPHLOHB_00013 5.2e-248 dacA 3.4.16.4 M Belongs to the peptidase S11 family
HPPHLOHB_00014 2.2e-157 pdxS 4.3.3.6 H Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HPPHLOHB_00015 8e-108 pdxT 4.3.3.6 H Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HPPHLOHB_00016 4.3e-207 serS 6.1.1.11 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPPHLOHB_00017 1.3e-09
HPPHLOHB_00018 2.2e-122 dck 2.7.1.113, 2.7.1.74, 2.7.1.76 F Deoxycytidine kinase
HPPHLOHB_00019 3.2e-115 dgk 2.7.1.113, 2.7.1.74, 2.7.1.76 F Deoxyguanosine kinase
HPPHLOHB_00020 5.6e-215 yaaH M Glycoside Hydrolase Family
HPPHLOHB_00021 2.4e-98 yaaI Q COG1335 Amidases related to nicotinamidase
HPPHLOHB_00022 1e-84 tadA 3.5.4.1, 3.5.4.3, 3.5.4.33 FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
HPPHLOHB_00023 0.0 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPPHLOHB_00024 5.3e-37 yaaK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HPPHLOHB_00025 3.9e-110 recR L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HPPHLOHB_00026 7.9e-32 yaaL S Protein of unknown function (DUF2508)
HPPHLOHB_00027 3.7e-36 bofA S Sigma-K factor-processing regulatory protein BofA
HPPHLOHB_00028 3.4e-39 S COG NOG14552 non supervised orthologous group
HPPHLOHB_00031 3.4e-31 csfB S Inhibitor of sigma-G Gin
HPPHLOHB_00032 4.7e-103 xpaC S 5-bromo-4-chloroindolyl phosphate hydrolysis protein
HPPHLOHB_00033 4.5e-203 yaaN P Belongs to the TelA family
HPPHLOHB_00034 1.1e-275 adiA 4.1.1.17, 4.1.1.18, 4.1.1.19 E Orn Lys Arg decarboxylase
HPPHLOHB_00035 3.6e-114 tmk 2.7.4.9 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPPHLOHB_00036 2.2e-54 yaaQ S protein conserved in bacteria
HPPHLOHB_00037 1.5e-71 yaaR S protein conserved in bacteria
HPPHLOHB_00038 2.2e-182 holB 2.7.7.7 L DNA polymerase III
HPPHLOHB_00039 2.1e-146 yaaT S stage 0 sporulation protein
HPPHLOHB_00040 4.8e-31 yabA L Involved in initiation control of chromosome replication
HPPHLOHB_00041 2.5e-138 yabB 2.1.1.223 S Conserved hypothetical protein 95
HPPHLOHB_00042 1.5e-49 yazA L endonuclease containing a URI domain
HPPHLOHB_00043 4.3e-158 rsmI 2.1.1.198 H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPPHLOHB_00044 8.8e-44 abrB K COG2002 Regulators of stationary sporulation gene expression
HPPHLOHB_00045 0.0 metG 6.1.1.10, 6.1.1.20 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPPHLOHB_00046 1.8e-144 tatD L hydrolase, TatD
HPPHLOHB_00047 4.3e-194 rpfB GH23 T protein conserved in bacteria
HPPHLOHB_00048 8.4e-99 rnmV 3.1.26.8 J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HPPHLOHB_00049 2.4e-156 ksgA 2.1.1.182 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
HPPHLOHB_00050 3.3e-137 yabG S peptidase
HPPHLOHB_00051 7.8e-39 veg S protein conserved in bacteria
HPPHLOHB_00052 8.3e-27 sspF S DNA topological change
HPPHLOHB_00053 4.1e-161 ispE 2.1.1.182, 2.7.1.148 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HPPHLOHB_00054 2.6e-152 purR 2.4.2.22, 2.4.2.7 F pur operon repressor
HPPHLOHB_00055 3.8e-63 yabJ 3.5.99.10 J translation initiation inhibitor, yjgF family
HPPHLOHB_00056 4.6e-48 spoVG D Essential for sporulation. Interferes with or is a negative regulator of the pathway leading to asymmetric septation
HPPHLOHB_00057 6.6e-230 glmU 2.3.1.157, 2.7.7.23 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPPHLOHB_00058 9.4e-175 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPPHLOHB_00059 3.9e-97 ctc J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HPPHLOHB_00060 8e-105 pth 3.1.1.29 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
HPPHLOHB_00061 2.4e-39 yabK S Peptide ABC transporter permease
HPPHLOHB_00062 0.0 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPPHLOHB_00063 1.5e-92 spoVT K stage V sporulation protein
HPPHLOHB_00064 2.4e-287 yabM S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
HPPHLOHB_00065 2.7e-245 mazG 3.6.1.66, 3.6.1.9 S COG3956 Protein containing tetrapyrrole methyltransferase domain and MazG-like
HPPHLOHB_00066 1.1e-37 yabO J COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
HPPHLOHB_00067 1.5e-49 yabP S Sporulation protein YabP
HPPHLOHB_00068 3.9e-108 yabQ S spore cortex biosynthesis protein
HPPHLOHB_00069 1.1e-44 divIC D Septum formation initiator
HPPHLOHB_00070 8.5e-58 yabR J RNA binding protein (contains ribosomal protein S1 domain)
HPPHLOHB_00073 0.0 spoIIE 3.1.3.16, 3.1.3.3 KT stage II sporulation protein E
HPPHLOHB_00074 1.5e-124 yabS S protein containing a von Willebrand factor type A (vWA) domain
HPPHLOHB_00075 6.7e-187 KLT serine threonine protein kinase
HPPHLOHB_00076 3.5e-274 tilS 2.4.2.8, 6.3.4.19 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
HPPHLOHB_00077 7.9e-94 hpt 2.4.2.8, 6.3.4.19 F Belongs to the purine pyrimidine phosphoribosyltransferase family
HPPHLOHB_00078 0.0 ftsH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPPHLOHB_00079 1.5e-146 coaX 2.7.1.33 F Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HPPHLOHB_00080 2.9e-162 hslO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HPPHLOHB_00081 3.1e-153 yacD 5.2.1.8 O peptidyl-prolyl isomerase
HPPHLOHB_00082 8.9e-170 cysK 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
HPPHLOHB_00083 4.7e-271 pabB 2.6.1.85 EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPPHLOHB_00084 1.5e-106 pabA 2.6.1.85, 4.1.3.27 EH Anthranilate synthase
HPPHLOHB_00085 1.6e-168 pabC 2.6.1.42, 4.1.3.38 EH 4-amino-4-deoxychorismate lyase
HPPHLOHB_00086 2.6e-160 folP 2.5.1.15, 2.7.6.3 H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPPHLOHB_00087 8.2e-63 folB 1.13.11.81, 2.5.1.15, 2.7.6.3, 4.1.2.25, 5.1.99.8 H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPPHLOHB_00088 2.7e-88 folK 1.13.11.81, 2.5.1.15, 2.7.6.3, 3.5.4.16, 4.1.2.25, 5.1.99.8 H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPPHLOHB_00089 4.1e-30 yazB K transcriptional
HPPHLOHB_00090 3.7e-190 dus J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPPHLOHB_00091 1.3e-287 lysS 6.1.1.6 J Belongs to the class-II aminoacyl-tRNA synthetase family
HPPHLOHB_00092 3.4e-39 S COG NOG14552 non supervised orthologous group
HPPHLOHB_00097 2e-08
HPPHLOHB_00102 3.4e-39 S COG NOG14552 non supervised orthologous group
HPPHLOHB_00103 2.9e-76 ctsR K Belongs to the CtsR family
HPPHLOHB_00104 4.7e-47 mcsA 2.7.14.1 S protein with conserved CXXC pairs
HPPHLOHB_00105 6.1e-202 mcsB 2.7.14.1, 2.7.3.2, 2.7.3.3 E Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity
HPPHLOHB_00106 0.0 clpC O Belongs to the ClpA ClpB family
HPPHLOHB_00107 9.6e-256 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPPHLOHB_00108 1.3e-196 disA 2.7.7.85 L Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HPPHLOHB_00109 2.7e-197 yacL S COG4956 Integral membrane protein (PIN domain superfamily)
HPPHLOHB_00110 3.8e-125 ispD 2.7.7.60, 4.6.1.12 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)
HPPHLOHB_00111 3.1e-86 ispF 2.1.1.228, 2.7.7.60, 4.6.1.12 I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)
HPPHLOHB_00112 1.9e-280 gltX 6.1.1.17, 6.1.1.24 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPPHLOHB_00113 7.2e-118 cysE 2.3.1.30 E Serine acetyltransferase
HPPHLOHB_00114 4.9e-273 cysS 6.1.1.16, 6.3.1.13 J Belongs to the class-I aminoacyl-tRNA synthetase family
HPPHLOHB_00115 1e-72 mrnC J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HPPHLOHB_00116 1.2e-135 trmH 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPPHLOHB_00117 1.2e-88 yacP S RNA-binding protein containing a PIN domain
HPPHLOHB_00118 4.4e-115 sigH K Belongs to the sigma-70 factor family
HPPHLOHB_00119 1e-21 secE U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
HPPHLOHB_00120 5.2e-96 nusG K Participates in transcription elongation, termination and antitermination
HPPHLOHB_00121 2.8e-70 rplK J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPPHLOHB_00122 1.1e-124 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
HPPHLOHB_00123 5.1e-79 rplJ J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HPPHLOHB_00124 1.3e-42 rplL J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
HPPHLOHB_00125 8.2e-108 rsmC 2.1.1.172 J Methyltransferase
HPPHLOHB_00126 0.0 rpoB 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HPPHLOHB_00127 0.0 rpoC 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HPPHLOHB_00128 8e-33 ybxF J Belongs to the eukaryotic ribosomal protein eL8 family
HPPHLOHB_00129 8.5e-72 rpsL J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HPPHLOHB_00130 6e-82 rpsG J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
HPPHLOHB_00131 0.0 fusA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPPHLOHB_00132 2.5e-225 tuf J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPPHLOHB_00133 9.1e-186 ybaC 3.4.11.5 S Alpha/beta hydrolase family
HPPHLOHB_00134 7.5e-49 rpsJ J Involved in the binding of tRNA to the ribosomes
HPPHLOHB_00135 6.3e-111 rplC J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPPHLOHB_00136 3e-105 rplD J Forms part of the polypeptide exit tunnel
HPPHLOHB_00137 1.2e-43 rplW J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
HPPHLOHB_00138 1.5e-155 rplB J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPPHLOHB_00139 3.7e-47 rpsS J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HPPHLOHB_00140 4.3e-53 rplV J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPPHLOHB_00141 6.2e-117 rpsC J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HPPHLOHB_00142 1.3e-75 rplP J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HPPHLOHB_00143 1.7e-25 rpmC J Belongs to the universal ribosomal protein uL29 family
HPPHLOHB_00144 3.5e-39 rpsQ J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HPPHLOHB_00145 3.9e-60 rplN J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HPPHLOHB_00146 6.2e-51 rplX J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HPPHLOHB_00147 4.6e-94 rplE J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPPHLOHB_00148 3.4e-28 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPPHLOHB_00149 3.9e-66 rpsH J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HPPHLOHB_00150 1.3e-93 rplF J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HPPHLOHB_00151 4e-57 rplR J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HPPHLOHB_00152 3.1e-84 rpsE J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HPPHLOHB_00153 1.9e-23 rpmD J Ribosomal protein L30
HPPHLOHB_00154 1.8e-72 rplO J binds to the 23S rRNA
HPPHLOHB_00155 4.2e-234 secY U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
HPPHLOHB_00156 5.7e-123 adk 2.7.4.3 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
HPPHLOHB_00157 3.7e-142 map 3.4.11.18 E Methionine aminopeptidase
HPPHLOHB_00158 1.1e-33 infA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPPHLOHB_00159 4.2e-13 rpmJ J Belongs to the bacterial ribosomal protein bL36 family
HPPHLOHB_00160 3.1e-57 rpsM J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPPHLOHB_00161 2.1e-64 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HPPHLOHB_00162 3.1e-170 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HPPHLOHB_00163 3.6e-58 rplQ J Ribosomal protein L17
HPPHLOHB_00164 5.1e-156 cbiO P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HPPHLOHB_00165 1.7e-154 ecfA2 3.6.3.55 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HPPHLOHB_00166 4.7e-119 ecfT P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HPPHLOHB_00167 2.8e-142 truA 5.4.99.12 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
HPPHLOHB_00168 6.4e-78 rplM J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HPPHLOHB_00169 4.7e-64 rpsI J Belongs to the universal ribosomal protein uS9 family
HPPHLOHB_00170 8.2e-145 ybaJ Q Methyltransferase domain
HPPHLOHB_00171 9.7e-66 ybaK S Protein of unknown function (DUF2521)
HPPHLOHB_00172 1.1e-132 cwlD 3.5.1.28 M n-acetylmuramoyl-L-alanine amidase
HPPHLOHB_00173 1.4e-198 mrp D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP
HPPHLOHB_00174 1.2e-84 gerD
HPPHLOHB_00175 1.3e-102 kbaA 2.7.8.43 S Involved in the activation of the KinB signaling pathway of sporulation
HPPHLOHB_00176 1.2e-140 pdaB 3.5.1.104 G Polysaccharide deacetylase
HPPHLOHB_00177 3.4e-39 S COG NOG14552 non supervised orthologous group
HPPHLOHB_00180 2e-08
HPPHLOHB_00184 3.4e-39 S COG NOG14552 non supervised orthologous group
HPPHLOHB_00185 3.4e-39 S COG NOG14552 non supervised orthologous group
HPPHLOHB_00186 4.6e-250 ybaR P COG0659 Sulfate permease and related transporters (MFS superfamily)
HPPHLOHB_00188 1.2e-161 ybaS 1.1.1.58 S Na -dependent transporter
HPPHLOHB_00189 2.2e-142 ybbA S Putative esterase
HPPHLOHB_00190 3e-179 feuC P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPPHLOHB_00191 1.1e-176 feuB P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPPHLOHB_00192 7.2e-167 feuA P Iron-uptake system-binding protein
HPPHLOHB_00193 5.4e-308 ybbB K COG2207 AraC-type DNA-binding domain-containing proteins
HPPHLOHB_00194 4.4e-241 ybbC 3.2.1.52 S protein conserved in bacteria
HPPHLOHB_00195 0.0 ybbD 3.2.1.52 G Belongs to the glycosyl hydrolase 3 family
HPPHLOHB_00196 4e-256 yfeW 3.4.16.4 V Belongs to the UPF0214 family
HPPHLOHB_00197 9.8e-234 ybbF 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
HPPHLOHB_00198 1.1e-150 ybbH K transcriptional
HPPHLOHB_00199 2.1e-163 murQ 4.2.1.126 G Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPPHLOHB_00200 6.4e-87 ybbJ J acetyltransferase
HPPHLOHB_00201 3.9e-78 ybbK 2.4.2.1, 6.3.2.4 S Protein of unknown function (DUF523)
HPPHLOHB_00207 8.5e-99 sigW K Belongs to the sigma-70 factor family. ECF subfamily
HPPHLOHB_00208 1.7e-103 rsiW K Is the anti-sigma factor for SigW. The presence of RsiW leads to the inactivation of SigW, and its proteolytic destruction to sigma-W activation
HPPHLOHB_00209 2.7e-146 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HPPHLOHB_00210 3e-225 ybbR S protein conserved in bacteria
HPPHLOHB_00211 9.3e-253 glmM 5.4.2.10 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPPHLOHB_00212 0.0 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
HPPHLOHB_00213 2.1e-176 alkA 3.2.2.21 L COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPPHLOHB_00214 1.4e-121 adaA 3.2.2.21 K Transcriptional regulator
HPPHLOHB_00215 5.1e-101 ogt 2.1.1.63, 3.2.2.21 L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPPHLOHB_00216 1.5e-278 ndhF 1.6.5.3 CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit
HPPHLOHB_00217 0.0 ybcC S Belongs to the UPF0753 family
HPPHLOHB_00218 3.7e-96 can 4.2.1.1 P carbonic anhydrase
HPPHLOHB_00219 3.9e-47
HPPHLOHB_00220 4.7e-61 ybcI S Uncharacterized conserved protein (DUF2294)
HPPHLOHB_00221 5.1e-50 ybzH K Helix-turn-helix domain
HPPHLOHB_00222 2e-203 ybcL EGP Major facilitator Superfamily
HPPHLOHB_00224 9.1e-239 J 4Fe-4S single cluster domain
HPPHLOHB_00225 1.6e-277 V CAAX protease self-immunity
HPPHLOHB_00226 1.9e-135 skfE V ABC transporter
HPPHLOHB_00227 4e-248 skfF S ABC transporter
HPPHLOHB_00228 7.8e-91 C HEAT repeats
HPPHLOHB_00229 9.6e-79 txn CO Thioredoxin-like
HPPHLOHB_00230 6.2e-182 S hydrolases or acyltransferases (alpha beta hydrolase superfamily)
HPPHLOHB_00231 1.5e-123 T Transcriptional regulatory protein, C terminal
HPPHLOHB_00232 1.8e-173 T His Kinase A (phospho-acceptor) domain
HPPHLOHB_00234 1.6e-140 KLT Protein tyrosine kinase
HPPHLOHB_00235 4.8e-154 ybdN
HPPHLOHB_00236 1.5e-217 ybdO S Domain of unknown function (DUF4885)
HPPHLOHB_00237 2.4e-259 yifK E COG1113 Gamma-aminobutyrate permease and related permeases
HPPHLOHB_00238 3.7e-38 csgA S Sigma-G-dependent sporulation-specific SASP protein
HPPHLOHB_00239 4.9e-30 ybxH S Family of unknown function (DUF5370)
HPPHLOHB_00240 7.2e-152 ybxI 3.5.2.6 V beta-lactamase
HPPHLOHB_00241 1.4e-247 cypC 1.11.2.4, 1.14.14.1 Q Cytochrome P450
HPPHLOHB_00242 4.9e-41 ybyB
HPPHLOHB_00243 1.8e-290 ybeC E amino acid
HPPHLOHB_00244 5.6e-166 glpQ 3.1.4.46 C glycerophosphoryl diester phosphodiesterase
HPPHLOHB_00245 7.3e-258 glpT G -transporter
HPPHLOHB_00246 2.9e-35 S Protein of unknown function (DUF2651)
HPPHLOHB_00247 1.6e-171 ybfA 3.4.15.5 K FR47-like protein
HPPHLOHB_00248 2.2e-224 ybfB G COG0477 Permeases of the major facilitator superfamily
HPPHLOHB_00250 0.0 ybfG 3.2.1.132 M Domain of unknown function (DUF1906)
HPPHLOHB_00251 8.8e-162 ybfH EG EamA-like transporter family
HPPHLOHB_00252 2.3e-145 msmR K AraC-like ligand binding domain
HPPHLOHB_00253 1.9e-214 purT 2.1.2.2 F Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HPPHLOHB_00254 6.9e-178 mpr 3.4.21.19 M Belongs to the peptidase S1B family
HPPHLOHB_00256 2.5e-169 S Alpha/beta hydrolase family
HPPHLOHB_00257 3.2e-95 pssA 2.7.8.8 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPPHLOHB_00258 2.7e-85 ybfM S SNARE associated Golgi protein
HPPHLOHB_00259 5.6e-149 psd 4.1.1.65 I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)
HPPHLOHB_00260 3.2e-46 ybfN
HPPHLOHB_00261 4.3e-258 S Erythromycin esterase
HPPHLOHB_00262 6.7e-167 ybfP K Transcriptional regulator
HPPHLOHB_00263 3.9e-192 yceA S Belongs to the UPF0176 family
HPPHLOHB_00264 4.9e-216 gltP C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
HPPHLOHB_00265 0.0 ptsG 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
HPPHLOHB_00266 2.1e-137 nagB 3.1.1.31, 3.5.99.6 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
HPPHLOHB_00267 4.9e-128 K UTRA
HPPHLOHB_00269 5.4e-203 ilvE 2.6.1.42 E Branched-chain amino acid aminotransferase
HPPHLOHB_00270 6.7e-262 mmuP E amino acid
HPPHLOHB_00271 9.3e-183 mmuM 1.5.1.20, 2.1.1.10 H homocysteine
HPPHLOHB_00272 2.3e-257 agcS E Sodium alanine symporter
HPPHLOHB_00273 1.5e-188 glsA 3.5.1.2 E Belongs to the glutaminase family
HPPHLOHB_00274 1.5e-229 phoQ 2.7.13.3 T Histidine kinase
HPPHLOHB_00275 9e-170 glnL T Regulator
HPPHLOHB_00276 2.7e-174 kdgD 4.2.1.41 EM 5-dehydro-4-deoxyglucarate dehydratase activity
HPPHLOHB_00277 3.7e-274 ycbD C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
HPPHLOHB_00278 1.2e-255 gudP G COG0477 Permeases of the major facilitator superfamily
HPPHLOHB_00279 2.2e-270 gudD 4.2.1.40 M Belongs to the mandelate racemase muconate lactonizing enzyme family
HPPHLOHB_00280 1.5e-124 ycbG K FCD
HPPHLOHB_00281 3.7e-298 garD 4.2.1.42, 4.2.1.7 G Altronate
HPPHLOHB_00282 1.8e-178 ycbJ S Macrolide 2'-phosphotransferase
HPPHLOHB_00283 4.4e-24 rtpA K Tryptophan RNA-binding attenuator protein inhibitory protein
HPPHLOHB_00284 7.3e-172 eamA1 EG spore germination
HPPHLOHB_00285 1.7e-125 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HPPHLOHB_00286 2.4e-170 T PhoQ Sensor
HPPHLOHB_00287 4.8e-168 ycbN V ABC transporter, ATP-binding protein
HPPHLOHB_00288 2.1e-115 S ABC-2 family transporter protein
HPPHLOHB_00289 8.2e-53 ycbP S Protein of unknown function (DUF2512)
HPPHLOHB_00290 1.3e-78 sleB 3.5.1.28 M Cell wall
HPPHLOHB_00291 6.6e-136 ycbR T vWA found in TerF C terminus
HPPHLOHB_00292 0.0 phoD 3.1.3.1 P COG3540 Phosphodiesterase alkaline phosphatase D
HPPHLOHB_00293 5e-28 tatA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
HPPHLOHB_00294 1.2e-124 tatC U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPPHLOHB_00295 1.4e-121 pcp 3.4.19.3 O Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HPPHLOHB_00296 6.2e-210 ycbU E Selenocysteine lyase
HPPHLOHB_00297 5.8e-229 lmrB EGP the major facilitator superfamily
HPPHLOHB_00298 4.8e-102 yxaF K Transcriptional regulator
HPPHLOHB_00299 2.2e-202 ansB 3.5.1.1 EJ COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D
HPPHLOHB_00300 5.6e-115 lip 3.1.1.3 S acetyltransferases and hydrolases with the alpha beta hydrolase fold
HPPHLOHB_00301 2e-59 S RDD family
HPPHLOHB_00302 9.5e-200 yccF K DNA-templated transcriptional preinitiation complex assembly
HPPHLOHB_00303 2e-161 2.7.13.3 T GHKL domain
HPPHLOHB_00304 1.2e-126 lytR_2 T LytTr DNA-binding domain
HPPHLOHB_00305 4.1e-133 natA 3.6.3.7 CP ATPases associated with a variety of cellular activities
HPPHLOHB_00306 4.5e-203 natB CP ABC-2 family transporter protein
HPPHLOHB_00307 1.6e-174 yccK C Aldo keto reductase
HPPHLOHB_00308 6.6e-177 ycdA S Domain of unknown function (DUF5105)
HPPHLOHB_00309 5.9e-282 ycdB K Belongs to the sigma-70 factor family. ECF subfamily
HPPHLOHB_00310 6.7e-268 ycdC K Belongs to the sigma-70 factor family. ECF subfamily
HPPHLOHB_00311 1.7e-95 cwlK M D-alanyl-D-alanine carboxypeptidase
HPPHLOHB_00312 5.5e-174 S response regulator aspartate phosphatase
HPPHLOHB_00313 1.6e-140 IQ Enoyl-(Acyl carrier protein) reductase
HPPHLOHB_00314 0.0 ycdG 3.2.1.10 GH13 G COG0366 Glycosidases
HPPHLOHB_00315 6.6e-168 adcA P Belongs to the bacterial solute-binding protein 9 family
HPPHLOHB_00316 2.5e-132 adcC P 'COG1121 ABC-type Mn Zn transport systems, ATPase component'
HPPHLOHB_00317 1.7e-135 adcB P COG1108 ABC-type Mn2 Zn2 transport systems, permease components
HPPHLOHB_00318 5.4e-189 yceB C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPPHLOHB_00319 3.9e-110 yceC 3.5.4.33 T proteins involved in stress response, homologs of TerZ and
HPPHLOHB_00320 2.8e-105 yceD T proteins involved in stress response, homologs of TerZ and
HPPHLOHB_00321 4.6e-108 yceE T proteins involved in stress response, homologs of TerZ and
HPPHLOHB_00322 6.3e-137 terC P Protein of unknown function (DUF475)
HPPHLOHB_00323 0.0 yceG S Putative component of 'biosynthetic module'
HPPHLOHB_00324 2e-192 yceH P Belongs to the TelA family
HPPHLOHB_00325 1e-218 naiP P Uncharacterised MFS-type transporter YbfB
HPPHLOHB_00326 1.9e-209 yceJ EGP Uncharacterised MFS-type transporter YbfB
HPPHLOHB_00327 1.6e-45 K helix_turn_helix, Arsenical Resistance Operon Repressor
HPPHLOHB_00328 5.1e-229 proV 3.6.3.32 E glycine betaine
HPPHLOHB_00329 1.3e-127 opuAB P glycine betaine
HPPHLOHB_00330 5.3e-164 opuAC E glycine betaine
HPPHLOHB_00331 1.2e-219 amhX S amidohydrolase
HPPHLOHB_00332 1e-257 ycgA S Membrane
HPPHLOHB_00333 1.1e-98 ycgB
HPPHLOHB_00334 0.0 amyE 3.2.1.1 GH13 G alpha-amylase
HPPHLOHB_00335 3.3e-183 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
HPPHLOHB_00336 6.5e-293 lctP C L-lactate permease
HPPHLOHB_00337 6.2e-269 mdr EGP Major facilitator Superfamily
HPPHLOHB_00338 3.4e-77 emrR K helix_turn_helix multiple antibiotic resistance protein
HPPHLOHB_00339 6.8e-113 ycgF E Lysine exporter protein LysE YggA
HPPHLOHB_00340 1.2e-151 yqcI S YqcI/YcgG family
HPPHLOHB_00341 5.6e-250 ycgH E COG1113 Gamma-aminobutyrate permease and related permeases
HPPHLOHB_00342 2.4e-112 ycgI S Domain of unknown function (DUF1989)
HPPHLOHB_00343 1.5e-149 nadE 6.3.1.5 H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
HPPHLOHB_00344 2.5e-109 tmrB S AAA domain
HPPHLOHB_00345 3e-104 aroK 2.7.1.71, 4.2.3.4 F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPPHLOHB_00346 3.6e-145 yafE Q ubiE/COQ5 methyltransferase family
HPPHLOHB_00347 2.2e-179 oxyR3 K LysR substrate binding domain
HPPHLOHB_00348 2.9e-184 cah 3.1.1.41 Q Acetyl xylan esterase (AXE1)
HPPHLOHB_00349 2.9e-145 ycgL S Predicted nucleotidyltransferase
HPPHLOHB_00350 5.1e-170 ycgM E Proline dehydrogenase
HPPHLOHB_00351 7.3e-294 rocA 1.2.1.88, 1.5.5.2 C Belongs to the aldehyde dehydrogenase family. RocA subfamily
HPPHLOHB_00352 5.1e-149 putP E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPPHLOHB_00353 1.3e-76 putP E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPPHLOHB_00354 1.6e-227 ycgP QT COG2508 Regulator of polyketide synthase expression
HPPHLOHB_00355 2.6e-147 ycgQ S membrane
HPPHLOHB_00356 1.2e-139 ycgR S permeases
HPPHLOHB_00357 5.7e-163 I alpha/beta hydrolase fold
HPPHLOHB_00358 1.3e-193 ycgT 1.18.1.2, 1.19.1.1 C Ferredoxin--NADP reductase
HPPHLOHB_00359 9.3e-283 cobA 2.1.1.107, 4.2.1.75 H Belongs to the precorrin methyltransferase family
HPPHLOHB_00360 4.6e-57 nirD 1.7.1.15 P Nitrite reductase
HPPHLOHB_00361 0.0 nirB 1.7.1.15 C Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPPHLOHB_00362 0.0 nasC C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HPPHLOHB_00363 0.0 nirB 1.7.1.15 C Assimilatory nitrate reductase (electron transfer subunit)
HPPHLOHB_00364 7.6e-222 nasA P COG2223 Nitrate nitrite transporter
HPPHLOHB_00365 1.4e-172 folE2 3.5.4.16 S Converts GTP to 7,8-dihydroneopterin triphosphate
HPPHLOHB_00366 5.5e-109 yciB M ErfK YbiS YcfS YnhG
HPPHLOHB_00367 1.4e-228 yciC S GTPases (G3E family)
HPPHLOHB_00368 2.4e-116 yecS P COG0765 ABC-type amino acid transport system, permease component
HPPHLOHB_00369 1.1e-132 yckB ET COG0834 ABC-type amino acid transport signal transduction systems, periplasmic component domain
HPPHLOHB_00372 3.3e-77 yckC S membrane
HPPHLOHB_00373 3.5e-52 yckD S Protein of unknown function (DUF2680)
HPPHLOHB_00374 1.2e-298 yckE 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
HPPHLOHB_00375 3.4e-70 nin S Competence protein J (ComJ)
HPPHLOHB_00376 3.2e-72 nucA M Deoxyribonuclease NucA/NucB
HPPHLOHB_00377 3e-187 tlpC 2.7.13.3 NT chemotaxis protein
HPPHLOHB_00378 4.6e-97 hxlB 4.1.2.43, 5.3.1.27 G SIS domain
HPPHLOHB_00379 3.3e-107 hxlA 4.1.2.43 G 3-hexulose-6-phosphate synthase
HPPHLOHB_00380 1.3e-63 hxlR K transcriptional
HPPHLOHB_00381 0.0 srfAA Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HPPHLOHB_00382 0.0 srfAB Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HPPHLOHB_00383 0.0 srfAC Q COG1020 Non-ribosomal peptide synthetase modules and related proteins
HPPHLOHB_00384 5.7e-140 srfAD Q thioesterase
HPPHLOHB_00385 4.2e-228 EGP Major Facilitator Superfamily
HPPHLOHB_00386 4.9e-91 S YcxB-like protein
HPPHLOHB_00387 7.4e-164 ycxC EG EamA-like transporter family
HPPHLOHB_00388 4.4e-255 ycxD K GntR family transcriptional regulator
HPPHLOHB_00389 5.5e-113 acpT 2.7.8.7 H Belongs to the P-Pant transferase superfamily
HPPHLOHB_00390 4.4e-115 yczE S membrane
HPPHLOHB_00391 2.8e-134 tcyC 3.6.3.21 E COG1126 ABC-type polar amino acid transport system, ATPase component
HPPHLOHB_00392 6.2e-123 tcyB P COG0765 ABC-type amino acid transport system, permease component
HPPHLOHB_00393 1.5e-141 tcyA ET Belongs to the bacterial solute-binding protein 3 family
HPPHLOHB_00394 4.9e-162 bsdA K LysR substrate binding domain
HPPHLOHB_00395 2e-109 ubiX 2.5.1.129 H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN
HPPHLOHB_00396 1.8e-283 yclC 4.1.1.61 H Decarboxylase involved in the decarboxylation and detoxification of phenolic derivatives under both aerobic and anaerobic conditions. It is able to catalyze the reversible decarboxylation of 4-hydroxybenzoate
HPPHLOHB_00397 4e-39 bsdD 4.1.1.61 S response to toxic substance
HPPHLOHB_00398 1.1e-83 yclD
HPPHLOHB_00399 6.2e-162 yclE 3.4.11.5 S Alpha beta hydrolase
HPPHLOHB_00400 1.5e-267 dtpT E amino acid peptide transporter
HPPHLOHB_00401 2.9e-310 yclG M Pectate lyase superfamily protein
HPPHLOHB_00403 6.8e-282 gerKA EG Spore germination protein
HPPHLOHB_00404 1.3e-232 gerKC S spore germination
HPPHLOHB_00405 9.9e-200 gerKB F Spore germination protein
HPPHLOHB_00406 3.9e-122 yclH P ABC transporter
HPPHLOHB_00407 1.7e-204 yclI V ABC transporter (permease) YclI
HPPHLOHB_00408 1.4e-127 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HPPHLOHB_00409 1.8e-262 yclK 2.7.13.3 T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain
HPPHLOHB_00410 5.2e-71 S aspartate phosphatase
HPPHLOHB_00413 7.5e-242 lysC 2.7.2.4 E Belongs to the aspartokinase family
HPPHLOHB_00414 1.6e-161 yclN P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPPHLOHB_00415 2.6e-164 fatC P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPPHLOHB_00416 4.7e-137 yclP 3.6.3.34 P ABC transporter, ATP-binding protein
HPPHLOHB_00417 5.5e-175 yclQ P COG4607 ABC-type enterochelin transport system, periplasmic component
HPPHLOHB_00418 1.4e-251 ycnB EGP Major facilitator Superfamily
HPPHLOHB_00419 6.5e-154 ycnC K Transcriptional regulator
HPPHLOHB_00420 4.4e-135 nfrA2 1.5.1.38, 1.5.1.39 C Oxidoreductase
HPPHLOHB_00421 1.6e-45 ycnE S Monooxygenase
HPPHLOHB_00422 2.2e-51 yczG K helix_turn_helix, Arsenical Resistance Operon Repressor
HPPHLOHB_00423 1.3e-273 gabR K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
HPPHLOHB_00424 4.4e-247 gabT 2.6.1.19, 2.6.1.22 E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPPHLOHB_00425 3.4e-266 gabD 1.2.1.16, 1.2.1.20, 1.2.1.79 C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
HPPHLOHB_00426 6.1e-149 glcU U Glucose uptake
HPPHLOHB_00427 9.9e-146 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HPPHLOHB_00428 1.3e-100 ycnI S protein conserved in bacteria
HPPHLOHB_00429 1.4e-308 ycnJ P protein, homolog of Cu resistance protein CopC
HPPHLOHB_00430 1.7e-107 ycnK K COG1349 Transcriptional regulators of sugar metabolism
HPPHLOHB_00431 7.3e-56
HPPHLOHB_00432 5.6e-240 mtlA 2.7.1.197 G COG2213 Phosphotransferase system, mannitol-specific IIBC component
HPPHLOHB_00433 2e-71 mtlF 2.7.1.197 G COG4668 Mannitol fructose-specific phosphotransferase system, IIA domain
HPPHLOHB_00434 7.3e-211 mtlD 1.1.1.17 G COG0246 Mannitol-1-phosphate altronate dehydrogenases
HPPHLOHB_00435 3.8e-201 ycsA 1.1.1.83, 1.1.1.93, 4.1.1.73 CE Tartrate dehydrogenase
HPPHLOHB_00436 3.2e-10 sipT 3.4.21.89 U Belongs to the peptidase S26 family
HPPHLOHB_00437 7.6e-76 sipT 3.4.21.89 U Belongs to the peptidase S26 family
HPPHLOHB_00438 5e-113 M1-673 3.1.1.45 Q COG0412 Dienelactone hydrolase and related enzymes
HPPHLOHB_00439 5.4e-68 fabZ 3.5.1.108, 4.2.1.59 I FabA-like domain
HPPHLOHB_00441 8e-137 ycsE 3.1.3.104 S Sucrose-6F-phosphate phosphohydrolase
HPPHLOHB_00442 1.2e-140 ycsF S Belongs to the UPF0271 (lamB) family
HPPHLOHB_00443 6.5e-213 ycsG P COG1914 Mn2 and Fe2 transporters of the NRAMP family
HPPHLOHB_00444 9.6e-149 ycsI S Belongs to the D-glutamate cyclase family
HPPHLOHB_00445 1.9e-135 kipI 3.5.1.54 E Allophanate hydrolase subunit 1
HPPHLOHB_00446 5.1e-187 kipA 6.3.4.6 E Allophanate hydrolase subunit 2
HPPHLOHB_00447 1.2e-132 kipR K Transcriptional regulator
HPPHLOHB_00448 9.9e-120 ycsK E anatomical structure formation involved in morphogenesis
HPPHLOHB_00450 1.4e-49 yczJ S biosynthesis
HPPHLOHB_00451 0.0 pbpC 3.4.16.4 M Penicillin-binding Protein
HPPHLOHB_00452 2.8e-176 ydhF S Oxidoreductase
HPPHLOHB_00453 0.0 mtlR K transcriptional regulator, MtlR
HPPHLOHB_00454 1.4e-294 ydaB IQ acyl-CoA ligase
HPPHLOHB_00455 1.1e-99 ydaC Q Methyltransferase domain
HPPHLOHB_00456 1.4e-161 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HPPHLOHB_00457 1.2e-96 MA20_27600 5.3.1.15 S Cupin 2, conserved barrel domain protein
HPPHLOHB_00458 5e-104 rimL 1.1.1.25 J COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
HPPHLOHB_00459 6.8e-77 ydaG 1.4.3.5 S general stress protein
HPPHLOHB_00460 4.1e-139 amj U Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane
HPPHLOHB_00461 5.1e-47 ydzA EGP Major facilitator Superfamily
HPPHLOHB_00462 2.5e-74 lrpC K Transcriptional regulator
HPPHLOHB_00463 0.0 topB 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPPHLOHB_00464 1.9e-208 ydaJ M Belongs to the glycosyl hydrolase 8 (cellulase D) family
HPPHLOHB_00465 2e-152 ydaK T Diguanylate cyclase, GGDEF domain
HPPHLOHB_00466 0.0 ydaL S Uncharacterized protein conserved in bacteria (DUF2334)
HPPHLOHB_00467 4.5e-233 ydaM M Glycosyl transferase family group 2
HPPHLOHB_00468 0.0 ydaN S Bacterial cellulose synthase subunit
HPPHLOHB_00469 0.0 ydaO E amino acid
HPPHLOHB_00470 4.6e-79 mutT 3.6.1.13, 3.6.1.55 L Belongs to the Nudix hydrolase family
HPPHLOHB_00471 0.0 poxB 1.2.3.3, 1.2.5.1 EH Belongs to the TPP enzyme family
HPPHLOHB_00472 9.4e-40
HPPHLOHB_00473 1e-224 mntH P H( )-stimulated, divalent metal cation uptake system
HPPHLOHB_00475 3.3e-77 ydaT S Uncharacterized protein conserved in bacteria (DUF2188)
HPPHLOHB_00476 3.8e-148 ydbA 3.6.3.4, 3.6.3.54 P EcsC protein family
HPPHLOHB_00478 8.9e-59 ydbB G Cupin domain
HPPHLOHB_00479 2.8e-63 ydbC S Domain of unknown function (DUF4937
HPPHLOHB_00480 3.2e-155 ydbD P Catalase
HPPHLOHB_00481 2.7e-199 dctB G COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component
HPPHLOHB_00482 2.5e-297 dctS 2.7.13.3 T Signal transduction histidine kinase regulating citrate malate metabolism
HPPHLOHB_00483 8.1e-120 dctR T COG4565 Response regulator of citrate malate metabolism
HPPHLOHB_00484 6.3e-227 dctA U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
HPPHLOHB_00485 4.4e-181 ydbI S AI-2E family transporter
HPPHLOHB_00486 3.6e-171 ydbJ V ABC transporter, ATP-binding protein
HPPHLOHB_00487 5.5e-125 ydbK S COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
HPPHLOHB_00488 2.7e-52 ydbL
HPPHLOHB_00489 3e-220 ydbM 1.3.8.1 I acyl-CoA dehydrogenase
HPPHLOHB_00490 1.1e-18 S Fur-regulated basic protein B
HPPHLOHB_00491 2.2e-07 S Fur-regulated basic protein A
HPPHLOHB_00492 1.9e-150 yeaB P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPPHLOHB_00493 2.3e-56 ydbP 2.7.1.180, 5.3.4.1 CO Thioredoxin
HPPHLOHB_00494 4.6e-202 ddl 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
HPPHLOHB_00495 1.9e-259 murF 6.3.2.10 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
HPPHLOHB_00496 9e-249 cshA 3.6.4.13 JKL DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
HPPHLOHB_00497 2.1e-82 ydbS S Bacterial PH domain
HPPHLOHB_00498 2.2e-263 ydbT S Membrane
HPPHLOHB_00499 1.8e-107 ydcA 3.4.21.105 S membrane protein (homolog of Drosophila rhomboid)
HPPHLOHB_00500 2.5e-59 acpS 2.7.6.3, 2.7.8.7, 5.1.1.1 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
HPPHLOHB_00501 2.9e-183 ydcC M COG2834 Outer membrane lipoprotein-sorting protein
HPPHLOHB_00502 2.3e-223 alr 5.1.1.1, 5.1.1.5 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPPHLOHB_00503 4.8e-42 ndoAI K transcriptional regulators containing the CopG Arc MetJ DNA-binding domain and a metal-binding domain
HPPHLOHB_00504 2.5e-56 ndoA L Toxic component of a toxin-antitoxin (TA) module
HPPHLOHB_00505 1.3e-143 rsbR T Positive regulator of sigma-B
HPPHLOHB_00506 5.2e-57 rsbS T antagonist
HPPHLOHB_00507 1.3e-69 rsbT 2.7.11.1 T COG2172 Anti-sigma regulatory factor (Ser Thr protein kinase)
HPPHLOHB_00508 7.1e-189 rsbU 3.1.3.3 KT phosphatase
HPPHLOHB_00509 7e-53 rsbV T Belongs to the anti-sigma-factor antagonist family
HPPHLOHB_00510 2.4e-86 rsbW 2.7.11.1 F Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B)
HPPHLOHB_00511 3.4e-138 sigB K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPPHLOHB_00512 4.8e-108 rsbX 3.1.3.16, 3.1.3.3 KT Sigma factor PP2C-like phosphatases
HPPHLOHB_00516 1.5e-82 ydcG S EVE domain
HPPHLOHB_00517 1.6e-76 ydcH K helix_turn_helix multiple antibiotic resistance protein
HPPHLOHB_00518 0.0 yhgF K COG2183 Transcriptional accessory protein
HPPHLOHB_00519 1.6e-84 ydcK S Belongs to the SprT family
HPPHLOHB_00527 1.9e-211 L Belongs to the 'phage' integrase family
HPPHLOHB_00528 1.3e-90 immA E IrrE N-terminal-like domain
HPPHLOHB_00529 4.3e-62 yvaO K Transcriptional
HPPHLOHB_00530 1.1e-16
HPPHLOHB_00531 8.3e-41
HPPHLOHB_00533 5.1e-63 S Bacterial protein of unknown function (DUF961)
HPPHLOHB_00534 1e-273 ydcQ D Ftsk spoiiie family protein
HPPHLOHB_00535 1.5e-205 nicK L Replication initiation factor
HPPHLOHB_00538 1.2e-32 yddA
HPPHLOHB_00539 1.5e-173 yddB S Conjugative transposon protein TcpC
HPPHLOHB_00540 3e-40 yddC
HPPHLOHB_00541 2.4e-95 yddD S TcpE family
HPPHLOHB_00542 0.0 yddE S AAA-like domain
HPPHLOHB_00543 2e-55 S Domain of unknown function (DUF1874)
HPPHLOHB_00544 0.0 yddG S maturation of SSU-rRNA
HPPHLOHB_00545 2.4e-189 yddH CBM50 M Lysozyme-like
HPPHLOHB_00546 8.7e-87 yddI
HPPHLOHB_00547 4.1e-65 S Domain of unknown function with cystatin-like fold (DUF4467)
HPPHLOHB_00548 9.5e-128 S TIR domain
HPPHLOHB_00549 1.4e-74 S response regulator aspartate phosphatase
HPPHLOHB_00551 3.4e-161
HPPHLOHB_00552 2.7e-188 luxA C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPPHLOHB_00553 2.4e-71 lrpA K transcriptional
HPPHLOHB_00554 3.9e-78 lrpB K transcriptional
HPPHLOHB_00555 9.6e-100 yddQ 3.5.1.19 Q Isochorismatase family
HPPHLOHB_00556 1.5e-143 yddR S Zn-dependent hydrolases of the beta-lactamase fold
HPPHLOHB_00557 5e-227 ydeG EGP Major facilitator Superfamily
HPPHLOHB_00562 1.4e-112 ydeA 1.11.1.6, 3.5.1.124 S DJ-1/PfpI family
HPPHLOHB_00563 8.7e-30 cspL K Cold shock
HPPHLOHB_00564 6.1e-79 carD K Transcription factor
HPPHLOHB_00565 4.6e-35 ydzE EG spore germination
HPPHLOHB_00566 1.1e-166 rhaS5 K AraC-like ligand binding domain
HPPHLOHB_00567 2.3e-173 yicL EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
HPPHLOHB_00568 2.5e-166 ydeE K AraC family transcriptional regulator
HPPHLOHB_00569 2.2e-265 K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
HPPHLOHB_00570 3.4e-220 ydeG EGP Major facilitator superfamily
HPPHLOHB_00571 2.9e-47 ydeH
HPPHLOHB_00572 8.9e-107 ydeI S Bacteriocin-protection, YdeI or OmpD-Associated
HPPHLOHB_00573 4e-116
HPPHLOHB_00574 1.8e-153 ydeK EG -transporter
HPPHLOHB_00575 1.5e-274 ydeL K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
HPPHLOHB_00576 4.2e-74 maoC I N-terminal half of MaoC dehydratase
HPPHLOHB_00577 8.6e-107 ydeN S Serine hydrolase
HPPHLOHB_00578 1.1e-58 K HxlR-like helix-turn-helix
HPPHLOHB_00579 1.9e-153 yqfU S Uncharacterized protein conserved in bacteria (DUF2179)
HPPHLOHB_00580 4.8e-69 ydeP K Transcriptional regulator
HPPHLOHB_00581 1.6e-108 ydeQ S NADPH-quinone reductase (modulator of drug activity B)
HPPHLOHB_00582 1.2e-195 ydeR EGP Major facilitator Superfamily
HPPHLOHB_00583 8.4e-105 ydeS K Transcriptional regulator
HPPHLOHB_00584 1.3e-57 arsR K transcriptional
HPPHLOHB_00585 5.2e-232 arsB P Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPPHLOHB_00586 7.2e-149 ydfB J GNAT acetyltransferase
HPPHLOHB_00587 1e-162 ydfC EG EamA-like transporter family
HPPHLOHB_00588 1.9e-275 ydfD K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
HPPHLOHB_00589 5.9e-117 ydfE S Flavin reductase like domain
HPPHLOHB_00590 2.7e-123 ydfF K helix_turn_helix, Arsenical Resistance Operon Repressor
HPPHLOHB_00591 1.5e-79 ydfG S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPPHLOHB_00593 5.3e-180 ydfH 2.7.13.3 T Histidine kinase
HPPHLOHB_00594 1.4e-110 ydfI K Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HPPHLOHB_00595 0.0 ydfJ S drug exporters of the RND superfamily
HPPHLOHB_00596 1.9e-177 S Alpha/beta hydrolase family
HPPHLOHB_00597 5.9e-118 S Protein of unknown function (DUF554)
HPPHLOHB_00598 3.2e-147 K Bacterial transcription activator, effector binding domain
HPPHLOHB_00599 1.6e-155 fieF P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPPHLOHB_00600 9.6e-112 ydfN C nitroreductase
HPPHLOHB_00601 3.6e-187 ydfO E COG0346 Lactoylglutathione lyase and related lyases
HPPHLOHB_00602 8.8e-63 mhqP S DoxX
HPPHLOHB_00603 1.3e-57 traF CO Thioredoxin
HPPHLOHB_00604 7.1e-15 ydgA S Spore germination protein gerPA/gerPF
HPPHLOHB_00605 6.3e-29
HPPHLOHB_00607 4.4e-118 ydfR S Protein of unknown function (DUF421)
HPPHLOHB_00608 5.2e-122 ydfS S Protein of unknown function (DUF421)
HPPHLOHB_00609 1.7e-75 cotP O Belongs to the small heat shock protein (HSP20) family
HPPHLOHB_00610 1.4e-37 ydgA S Spore germination protein gerPA/gerPF
HPPHLOHB_00611 1.3e-41 ydgB S Spore germination protein gerPA/gerPF
HPPHLOHB_00612 1.5e-101 K Bacterial regulatory proteins, tetR family
HPPHLOHB_00613 1.9e-53 S DoxX-like family
HPPHLOHB_00614 2.4e-86 yycN 2.3.1.128 K Acetyltransferase
HPPHLOHB_00615 4.2e-308 expZ S ABC transporter
HPPHLOHB_00616 4e-251 cycA E COG1113 Gamma-aminobutyrate permease and related permeases
HPPHLOHB_00617 4.6e-91 dinB S DinB family
HPPHLOHB_00618 4.7e-80 K helix_turn_helix multiple antibiotic resistance protein
HPPHLOHB_00619 0.0 ydgH S drug exporters of the RND superfamily
HPPHLOHB_00620 1e-113 drgA C nitroreductase
HPPHLOHB_00621 1.1e-69 ydgJ K Winged helix DNA-binding domain
HPPHLOHB_00622 2.5e-209 tcaB EGP Major facilitator Superfamily
HPPHLOHB_00623 1.2e-121 ydhB S membrane transporter protein
HPPHLOHB_00624 6.5e-122 ydhC K FCD
HPPHLOHB_00625 3.3e-244 ydhD M Glycosyl hydrolase
HPPHLOHB_00626 7e-228 ydhE CG COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase
HPPHLOHB_00627 1.9e-127
HPPHLOHB_00628 1.4e-259 phoB 3.1.3.1 P Belongs to the alkaline phosphatase family
HPPHLOHB_00629 4.6e-69 frataxin S Domain of unknown function (DU1801)
HPPHLOHB_00631 4.1e-86 K Acetyltransferase (GNAT) domain
HPPHLOHB_00632 1.8e-184 ydhJ S Metal dependent phosphohydrolases with conserved 'HD' motif.
HPPHLOHB_00633 1.7e-99 ydhK M Protein of unknown function (DUF1541)
HPPHLOHB_00634 4.6e-200 pbuE EGP Major facilitator Superfamily
HPPHLOHB_00635 1.1e-47 ydhM 2.7.1.196, 2.7.1.205 G phosphotransferase system
HPPHLOHB_00636 3.5e-52 ydhN3 2.7.1.196, 2.7.1.205 G phosphotransferase system
HPPHLOHB_00637 2e-239 celB G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HPPHLOHB_00638 2.4e-288 ydhP 3.2.1.21, 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
HPPHLOHB_00639 3.9e-133 ydhQ K UTRA
HPPHLOHB_00640 9.2e-172 gmuE 2.7.1.2, 2.7.1.4 GK COG1940 Transcriptional regulator sugar kinase
HPPHLOHB_00641 4.2e-191 manA 5.3.1.8 G mannose-6-phosphate isomerase
HPPHLOHB_00642 7.3e-216 gmuG 3.2.1.78 GH26 G Belongs to the glycosyl hydrolase 26 family
HPPHLOHB_00643 8.7e-78 ydhU P Catalase
HPPHLOHB_00644 1.1e-16 ydhU P Manganese containing catalase
HPPHLOHB_00647 3.4e-39 S COG NOG14552 non supervised orthologous group
HPPHLOHB_00648 7.8e-08
HPPHLOHB_00650 4.6e-185 thiL 2.7.4.16 H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HPPHLOHB_00651 9.1e-86 ydiB 2.7.1.221, 5.1.1.1 S ATPase or kinase
HPPHLOHB_00652 9e-127 yeaZ 2.3.1.234 O COG1214 Inactive homolog of metal-dependent proteases
HPPHLOHB_00653 1.3e-84 rimI 2.3.1.128 K This enzyme acetylates the N-terminal alanine of ribosomal protein S18
HPPHLOHB_00654 3.6e-188 tsaD 2.3.1.234 O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HPPHLOHB_00655 0.0 ydiF S ABC transporter
HPPHLOHB_00656 5.5e-89 moaC 4.6.1.17 H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)
HPPHLOHB_00657 8.8e-116 rex K Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HPPHLOHB_00658 7.5e-22 tatA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
HPPHLOHB_00659 8.4e-126 tatC U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPPHLOHB_00660 2.9e-27 ydiK S Domain of unknown function (DUF4305)
HPPHLOHB_00661 7.9e-129 ydiL S CAAX protease self-immunity
HPPHLOHB_00662 1.3e-42 groS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPPHLOHB_00663 1.2e-281 groL O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
HPPHLOHB_00665 6.4e-66 KL Phage plasmid primase P4 family
HPPHLOHB_00666 1.1e-250 2.1.1.37 L DNA (cytosine-5-)-methyltransferase activity
HPPHLOHB_00667 1.6e-232 ydiP 2.1.1.37 H Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family
HPPHLOHB_00669 1.2e-199 V AAA domain (dynein-related subfamily)
HPPHLOHB_00670 4.9e-257 J LlaJI restriction endonuclease
HPPHLOHB_00671 1.1e-08 ydjC S Abhydrolase domain containing 18
HPPHLOHB_00672 0.0 K NB-ARC domain
HPPHLOHB_00673 3.8e-201 gutB 1.1.1.14 E Dehydrogenase
HPPHLOHB_00674 7.1e-256 gutA G MFS/sugar transport protein
HPPHLOHB_00675 1.5e-175 ydjE 2.7.1.4 G pfkB family carbohydrate kinase
HPPHLOHB_00676 5.1e-114 pspA KT Phage shock protein A
HPPHLOHB_00677 3.4e-178 ydjG 3.6.4.12 L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPPHLOHB_00678 1.6e-137 ydjH S COG1512 Beta-propeller domains of methanol dehydrogenase type
HPPHLOHB_00679 1.4e-149 ydjI S virion core protein (lumpy skin disease virus)
HPPHLOHB_00680 4.7e-196 S Ion transport 2 domain protein
HPPHLOHB_00681 2.7e-258 iolT EGP Major facilitator Superfamily
HPPHLOHB_00682 5.2e-195 bdhA 1.1.1.303, 1.1.1.4 E Dehydrogenase
HPPHLOHB_00683 4.5e-64 ydjM M Lytic transglycolase
HPPHLOHB_00684 4.4e-157 ydjN U Involved in the tonB-independent uptake of proteins
HPPHLOHB_00686 1.4e-34 ydjO S Cold-inducible protein YdjO
HPPHLOHB_00687 9.5e-160 ydjP I Alpha/beta hydrolase family
HPPHLOHB_00688 2.4e-181 yeaA S Protein of unknown function (DUF4003)
HPPHLOHB_00689 0.0 cotA 1.10.3.4, 1.16.3.3 Q multicopper oxidases
HPPHLOHB_00690 2.6e-253 gabP E COG1113 Gamma-aminobutyrate permease and related permeases
HPPHLOHB_00691 7.6e-155 yeaB P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPPHLOHB_00692 1.6e-177 yeaC S COG0714 MoxR-like ATPases
HPPHLOHB_00693 9.5e-225 yeaD S conserved protein (some members contain a von Willebrand factor type A (vWA) domain)
HPPHLOHB_00694 0.0 yebA E COG1305 Transglutaminase-like enzymes
HPPHLOHB_00695 3.7e-306 guaA 2.3.1.128, 6.3.5.2 F Catalyzes the synthesis of GMP from XMP
HPPHLOHB_00696 6e-212 pbuG S permease
HPPHLOHB_00697 1.1e-118 yebC M Membrane
HPPHLOHB_00699 4e-93 yebE S UPF0316 protein
HPPHLOHB_00700 8e-28 yebG S NETI protein
HPPHLOHB_00701 2.5e-83 purE 5.4.99.18 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPPHLOHB_00702 7e-217 purK 6.3.4.18 F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPPHLOHB_00703 9.6e-247 purB 4.3.2.2 F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPPHLOHB_00704 1.2e-132 purC 4.1.1.21, 4.3.2.2, 6.3.2.6 F Belongs to the SAICAR synthetase family
HPPHLOHB_00705 2.9e-38 purS 6.3.2.6, 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPPHLOHB_00706 5.1e-130 purQ 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPPHLOHB_00707 0.0 purL 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPPHLOHB_00708 1.2e-271 purF 2.4.2.14 F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HPPHLOHB_00709 7.6e-178 purM 6.3.3.1, 6.3.4.13 F Phosphoribosylformylglycinamidine cyclo-ligase
HPPHLOHB_00710 1.3e-105 purN 2.1.2.2 F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPPHLOHB_00711 1.2e-288 purH 2.1.2.3, 3.5.4.10 F Bifunctional purine biosynthesis protein PurH
HPPHLOHB_00712 1.7e-235 purD 6.3.4.13 F Belongs to the GARS family
HPPHLOHB_00713 3.5e-73 K helix_turn_helix ASNC type
HPPHLOHB_00714 2.3e-232 yjeH E Amino acid permease
HPPHLOHB_00715 2.7e-27 S Protein of unknown function (DUF2892)
HPPHLOHB_00716 0.0 yerA 3.5.4.2 F adenine deaminase
HPPHLOHB_00717 3e-192 yerB S Protein of unknown function (DUF3048) C-terminal domain
HPPHLOHB_00718 4.8e-51 yerC S protein conserved in bacteria
HPPHLOHB_00719 3.2e-305 yerD 1.4.7.1 E Belongs to the glutamate synthase family
HPPHLOHB_00721 2.2e-125 pcrB I 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HPPHLOHB_00722 0.0 pcrA 3.6.4.12 L ATP-dependent DNA helicase
HPPHLOHB_00723 0.0 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPPHLOHB_00724 4.1e-220 camS S COG4851 Protein involved in sex pheromone biosynthesis
HPPHLOHB_00725 1.1e-197 yerI S homoserine kinase type II (protein kinase fold)
HPPHLOHB_00726 1.6e-123 sapB S MgtC SapB transporter
HPPHLOHB_00727 2e-264 putP E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPPHLOHB_00728 2.1e-45 gatC 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HPPHLOHB_00729 1.2e-274 gatA 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
HPPHLOHB_00730 3.1e-270 gatB 6.1.1.12, 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HPPHLOHB_00731 4e-156 yerO K Transcriptional regulator
HPPHLOHB_00732 0.0 swrC V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPPHLOHB_00733 3e-170 yegS 2.7.1.107 I COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
HPPHLOHB_00734 1.2e-255 rumA 2.1.1.190 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPPHLOHB_00735 3.2e-98 L Recombinase
HPPHLOHB_00736 3.2e-53 L Resolvase, N terminal domain
HPPHLOHB_00737 0.0 yeeA V Type II restriction enzyme, methylase subunits
HPPHLOHB_00738 0.0 yeeB L DEAD-like helicases superfamily
HPPHLOHB_00739 1.8e-212 pstS P T5orf172
HPPHLOHB_00741 6.2e-31 S Colicin immunity protein / pyocin immunity protein
HPPHLOHB_00742 5.5e-83 S Protein of unknown function, DUF600
HPPHLOHB_00743 0.0 L nucleic acid phosphodiester bond hydrolysis
HPPHLOHB_00744 1.8e-192 3.4.24.40 CO amine dehydrogenase activity
HPPHLOHB_00745 5.5e-214 S Tetratricopeptide repeat
HPPHLOHB_00747 9.4e-127 yeeN K transcriptional regulatory protein
HPPHLOHB_00749 1.2e-103 dhaR3 K Transcriptional regulator
HPPHLOHB_00750 9.7e-82 yesE S SnoaL-like domain
HPPHLOHB_00751 2.2e-159 yesF GM NAD(P)H-binding
HPPHLOHB_00752 5.3e-45 cotJA S Spore coat associated protein JA (CotJA)
HPPHLOHB_00753 1.5e-45 cotJB S CotJB protein
HPPHLOHB_00754 5.2e-104 cotJC P Spore Coat
HPPHLOHB_00755 4.2e-103 yesJ K Acetyltransferase (GNAT) family
HPPHLOHB_00757 4.4e-104 yesL S Protein of unknown function, DUF624
HPPHLOHB_00758 0.0 yesM 2.7.13.3 T Histidine kinase
HPPHLOHB_00759 2.9e-204 yesN K helix_turn_helix, arabinose operon control protein
HPPHLOHB_00760 5e-248 yesO G Bacterial extracellular solute-binding protein
HPPHLOHB_00761 2.8e-171 yesP G Binding-protein-dependent transport system inner membrane component
HPPHLOHB_00762 1.3e-165 yesQ P Binding-protein-dependent transport system inner membrane component
HPPHLOHB_00763 1.6e-199 3.2.1.172 GH105 S Glycosyl Hydrolase Family 88
HPPHLOHB_00764 0.0 yesS K Transcriptional regulator
HPPHLOHB_00765 3.8e-133 E GDSL-like Lipase/Acylhydrolase
HPPHLOHB_00766 8.9e-132 yesU S Domain of unknown function (DUF1961)
HPPHLOHB_00767 1e-113 yesV S Protein of unknown function, DUF624
HPPHLOHB_00768 0.0 yesX 4.2.2.23, 4.2.2.24 PL11 E cell wall organization
HPPHLOHB_00769 0.0 yesX 4.2.2.23, 4.2.2.24 PL11 E cell wall organization
HPPHLOHB_00770 3e-124 yesY E GDSL-like Lipase/Acylhydrolase
HPPHLOHB_00771 0.0 yesZ 3.2.1.23 G beta-galactosidase activity
HPPHLOHB_00772 0.0 yetA
HPPHLOHB_00773 9.6e-291 lplA G Bacterial extracellular solute-binding protein
HPPHLOHB_00774 1.3e-176 lplB G COG4209 ABC-type polysaccharide transport system, permease component
HPPHLOHB_00775 1.7e-162 lplC G Binding-protein-dependent transport system inner membrane component
HPPHLOHB_00776 3.3e-258 lplD 3.2.1.122, 3.2.1.22, 3.2.1.86 GH4,GT4 G Family 4 glycosyl hydrolase
HPPHLOHB_00777 6.1e-123 yetF S membrane
HPPHLOHB_00778 4.4e-55 isdI 1.14.99.48, 1.14.99.57 S Antibiotic biosynthesis monooxygenase
HPPHLOHB_00779 2e-64 yetH E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HPPHLOHB_00780 2.2e-34
HPPHLOHB_00781 2.2e-89 T COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
HPPHLOHB_00782 4.4e-43 T COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
HPPHLOHB_00783 8.9e-20 yezD S Uncharacterized small protein (DUF2292)
HPPHLOHB_00784 5.3e-105 yetJ S Belongs to the BI1 family
HPPHLOHB_00785 5.4e-159 yetK EG EamA-like transporter family
HPPHLOHB_00786 6.4e-90 yetL K helix_turn_helix multiple antibiotic resistance protein
HPPHLOHB_00787 7.8e-213 yetM CH FAD binding domain
HPPHLOHB_00788 3.6e-199 yetN S Protein of unknown function (DUF3900)
HPPHLOHB_00789 0.0 cypD 1.14.14.1, 1.6.2.4 C Belongs to the cytochrome P450 family
HPPHLOHB_00790 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
HPPHLOHB_00791 2.1e-148 rfbF 2.7.7.33 JM Nucleotidyl transferase
HPPHLOHB_00792 1.9e-172 yfnG 4.2.1.45 M dehydratase
HPPHLOHB_00793 3.8e-181 yfnF M Nucleotide-diphospho-sugar transferase
HPPHLOHB_00794 1.4e-225 yfnE 2.4.1.338 GT2 S Glycosyltransferase like family 2
HPPHLOHB_00795 3.5e-190 yfnD M Nucleotide-diphospho-sugar transferase
HPPHLOHB_00796 2e-206 fsr P COG0477 Permeases of the major facilitator superfamily
HPPHLOHB_00797 7.8e-134 yjjG 3.1.3.102, 3.1.3.104, 3.1.3.5, 3.8.1.2 S Haloacid dehalogenase-like hydrolase
HPPHLOHB_00798 1.3e-241 yfnA E amino acid
HPPHLOHB_00799 2.8e-279 yfmT 1.2.1.3, 1.2.1.67 C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
HPPHLOHB_00800 1.1e-113 yfmS NT chemotaxis protein
HPPHLOHB_00801 0.0 yfmR S COG0488 ATPase components of ABC transporters with duplicated ATPase domains
HPPHLOHB_00802 3e-75 yfmQ S Uncharacterised protein from bacillus cereus group
HPPHLOHB_00803 2.8e-70 yfmP K transcriptional
HPPHLOHB_00804 1.5e-209 yfmO EGP Major facilitator Superfamily
HPPHLOHB_00805 1.9e-297 yfmM S COG0488 ATPase components of ABC transporters with duplicated ATPase domains
HPPHLOHB_00806 6.3e-202 yfmL 3.6.4.13 L COG0513 Superfamily II DNA and RNA helicases
HPPHLOHB_00807 7.5e-82 yfmK 2.3.1.128 K acetyltransferase
HPPHLOHB_00808 8.5e-190 yfmJ S N-terminal domain of oxidoreductase
HPPHLOHB_00809 7.7e-214 G Major Facilitator Superfamily
HPPHLOHB_00810 3.3e-296 1.14.99.50 S Sulfatase-modifying factor enzyme 1
HPPHLOHB_00811 1.1e-149 yfmF 3.6.3.34 P ATPases associated with a variety of cellular activities
HPPHLOHB_00812 1.2e-169 fecD P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPPHLOHB_00813 4.3e-170 viuD P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPPHLOHB_00814 3.4e-169 fecB P COG4594 ABC-type Fe3 -citrate transport system, periplasmic component
HPPHLOHB_00815 2.9e-24 S Protein of unknown function (DUF3212)
HPPHLOHB_00816 7.6e-58 yflT S Heat induced stress protein YflT
HPPHLOHB_00817 3.8e-240 pel 4.2.2.10, 4.2.2.2 G Pectate lyase
HPPHLOHB_00818 3.2e-235 yflS P Sodium:sulfate symporter transmembrane region
HPPHLOHB_00819 1e-290 citS 2.7.13.3 T Signal transduction histidine kinase regulating citrate malate metabolism
HPPHLOHB_00820 8.9e-119 citT T response regulator
HPPHLOHB_00821 3e-181 yflP S Tripartite tricarboxylate transporter family receptor
HPPHLOHB_00823 8.5e-227 citM C Citrate transporter
HPPHLOHB_00824 5.5e-152 yflN S COG0491 Zn-dependent hydrolases, including glyoxylases
HPPHLOHB_00825 1.3e-217 nos 1.14.14.47 C Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HPPHLOHB_00826 2.9e-44 acyP 3.6.1.7 C Belongs to the acylphosphatase family
HPPHLOHB_00827 9e-124 yflK S protein conserved in bacteria
HPPHLOHB_00828 4e-18 yflJ S Protein of unknown function (DUF2639)
HPPHLOHB_00829 4.1e-19 yflI
HPPHLOHB_00830 2.4e-50 yflH S Protein of unknown function (DUF3243)
HPPHLOHB_00831 1.1e-138 map 3.4.11.18 E Methionine aminopeptidase
HPPHLOHB_00832 1.1e-250 nagE 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G COG1263 Phosphotransferase system IIC components, glucose maltose N-acetylglucosamine-specific
HPPHLOHB_00833 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
HPPHLOHB_00834 6e-67 yhdN S Domain of unknown function (DUF1992)
HPPHLOHB_00835 3.2e-256 agcS_1 E Sodium alanine symporter
HPPHLOHB_00836 1.6e-194 E Spore germination protein
HPPHLOHB_00838 5.1e-207 yfkR S spore germination
HPPHLOHB_00839 1.5e-283 yfkQ EG Spore germination protein
HPPHLOHB_00840 8.5e-257 treP 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
HPPHLOHB_00841 0.0 treC 3.2.1.93 GH13 G COG0366 Glycosidases
HPPHLOHB_00842 1.8e-133 treR K transcriptional
HPPHLOHB_00843 1.6e-125 yfkO C nitroreductase
HPPHLOHB_00844 0.0 cpdB 3.1.3.5, 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
HPPHLOHB_00845 1.6e-91 yfkM 1.11.1.6, 3.5.1.124 S protease
HPPHLOHB_00846 6.8e-207 ydiM EGP Major facilitator Superfamily
HPPHLOHB_00847 2.1e-29 yfkK S Belongs to the UPF0435 family
HPPHLOHB_00848 2.2e-84 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPPHLOHB_00849 8.4e-51 yfkI S gas vesicle protein
HPPHLOHB_00850 9.7e-144 yihY S Belongs to the UPF0761 family
HPPHLOHB_00851 5e-08
HPPHLOHB_00852 6.9e-220 ycaD EGP COG0477 Permeases of the major facilitator superfamily
HPPHLOHB_00853 6.1e-183 cax P COG0387 Ca2 H antiporter
HPPHLOHB_00854 1.2e-146 yfkD S YfkD-like protein
HPPHLOHB_00855 6e-149 yfkC M Mechanosensitive ion channel
HPPHLOHB_00856 5.4e-222 yfkA S YfkB-like domain
HPPHLOHB_00857 1.1e-26 yfjT
HPPHLOHB_00858 2.6e-154 pdaA G deacetylase
HPPHLOHB_00859 4.2e-150 yfjR 1.1.1.31 I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
HPPHLOHB_00860 1.7e-184 corA P Mediates influx of magnesium ions
HPPHLOHB_00861 1e-167 yfjP 3.2.2.21 L COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPPHLOHB_00862 1.1e-267 rumA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPPHLOHB_00863 1.6e-39 S YfzA-like protein
HPPHLOHB_00864 5.1e-192 yfjN J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPPHLOHB_00865 3.9e-86 yfjM S Psort location Cytoplasmic, score
HPPHLOHB_00866 3e-29 yfjL
HPPHLOHB_00867 1.2e-191 acoA C COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
HPPHLOHB_00868 1e-190 acoB C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
HPPHLOHB_00869 2.9e-197 acoC 2.3.1.12, 2.3.1.61 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
HPPHLOHB_00870 6.4e-257 acoL 1.8.1.4 C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
HPPHLOHB_00871 0.0 acoR KQ COG3284 Transcriptional activator of acetoin glycerol metabolism
HPPHLOHB_00872 1.2e-25 sspH S Belongs to the SspH family
HPPHLOHB_00873 4e-56 yfjF S UPF0060 membrane protein
HPPHLOHB_00874 1.3e-80 S Family of unknown function (DUF5381)
HPPHLOHB_00875 1.8e-101 yfjD S Family of unknown function (DUF5381)
HPPHLOHB_00876 4.1e-144 yfjC
HPPHLOHB_00877 9.2e-191 yfjB
HPPHLOHB_00878 1.1e-44 yfjA S Belongs to the WXG100 family
HPPHLOHB_00879 9.9e-263 aglB 3.2.1.122, 3.2.1.22, 3.2.1.86 GH4,GT4 G COG1486 Alpha-galactosidases 6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases
HPPHLOHB_00880 2.1e-140 glvR K Helix-turn-helix domain, rpiR family
HPPHLOHB_00881 4.7e-296 glvC 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
HPPHLOHB_00882 2.1e-310 yfiB3 V ABC transporter
HPPHLOHB_00883 0.0 yfiC V COG1132 ABC-type multidrug transport system, ATPase and permease components
HPPHLOHB_00884 9.8e-65 mhqP S DoxX
HPPHLOHB_00885 5.7e-163 yfiE 1.13.11.2 S glyoxalase
HPPHLOHB_00886 1.5e-177 K AraC-like ligand binding domain
HPPHLOHB_00887 1.8e-262 iolT EGP Major facilitator Superfamily
HPPHLOHB_00888 8.4e-184 G Xylose isomerase
HPPHLOHB_00889 1.1e-233 S Oxidoreductase
HPPHLOHB_00891 1.1e-214 yxjM T Histidine kinase
HPPHLOHB_00892 3.2e-113 KT LuxR family transcriptional regulator
HPPHLOHB_00893 6.2e-171 V ABC transporter, ATP-binding protein
HPPHLOHB_00894 9.8e-214 V ABC-2 family transporter protein
HPPHLOHB_00895 4.6e-208 V COG0842 ABC-type multidrug transport system, permease component
HPPHLOHB_00896 8.3e-99 padR K transcriptional
HPPHLOHB_00897 4.4e-80 estA 3.1.1.3 S acetyltransferases and hydrolases with the alpha beta hydrolase fold
HPPHLOHB_00898 9e-198 yfiQ G COG3936 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HPPHLOHB_00899 2e-109 yfiR K Transcriptional regulator
HPPHLOHB_00900 5.1e-221 yfiS EGP Major facilitator Superfamily
HPPHLOHB_00901 3.3e-100 yfiT S Belongs to the metal hydrolase YfiT family
HPPHLOHB_00902 8.7e-287 yfiU EGP Major facilitator Superfamily
HPPHLOHB_00903 3.1e-81 yfiV K transcriptional
HPPHLOHB_00904 0.0 mprF 2.3.2.3 S Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HPPHLOHB_00905 6.2e-182 yfiY P ABC transporter substrate-binding protein
HPPHLOHB_00906 3.1e-176 yfiZ P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPPHLOHB_00907 5.2e-171 yfhA P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPPHLOHB_00908 1.8e-167 yfhB 5.3.3.17 S PhzF family
HPPHLOHB_00909 3.9e-107 yfhC C nitroreductase
HPPHLOHB_00910 2.1e-25 yfhD S YfhD-like protein
HPPHLOHB_00912 4.9e-173 yfhF S nucleoside-diphosphate sugar epimerase
HPPHLOHB_00913 1.1e-141 recX 2.4.1.337 GT4 S Modulates RecA activity
HPPHLOHB_00914 9.7e-52 yfhH S Protein of unknown function (DUF1811)
HPPHLOHB_00916 1.1e-209 yfhI EGP Major facilitator Superfamily
HPPHLOHB_00917 6.2e-20 sspK S reproduction
HPPHLOHB_00918 1.3e-44 yfhJ S WVELL protein
HPPHLOHB_00919 9.2e-92 batE T Bacterial SH3 domain homologues
HPPHLOHB_00920 3.5e-51 yfhL S SdpI/YhfL protein family
HPPHLOHB_00921 6.7e-172 yfhM S Alpha beta hydrolase
HPPHLOHB_00922 2.7e-185 csbB GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
HPPHLOHB_00923 0.0 yfhO S Bacterial membrane protein YfhO
HPPHLOHB_00924 5.5e-186 yfhP S membrane-bound metal-dependent
HPPHLOHB_00925 7.8e-212 mutY L A G-specific
HPPHLOHB_00926 6.9e-36 yfhS
HPPHLOHB_00927 2.9e-134 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HPPHLOHB_00928 2.4e-08 sspE S Small, acid-soluble spore protein, gamma-type
HPPHLOHB_00929 1.5e-37 ygaB S YgaB-like protein
HPPHLOHB_00930 1.3e-104 ygaC J Belongs to the UPF0374 family
HPPHLOHB_00931 1.8e-301 ygaD V ABC transporter
HPPHLOHB_00932 8.7e-180 ygaE S Membrane
HPPHLOHB_00933 1.2e-246 gsaB 5.4.3.8 H Glutamate-1-semialdehyde aminotransferase
HPPHLOHB_00934 2.8e-87 bcp 1.11.1.15 O Peroxiredoxin
HPPHLOHB_00935 4e-80 perR P Belongs to the Fur family
HPPHLOHB_00936 1.5e-56 ygzB S UPF0295 protein
HPPHLOHB_00937 6.7e-167 ygxA S Nucleotidyltransferase-like
HPPHLOHB_00938 3.4e-39 S COG NOG14552 non supervised orthologous group
HPPHLOHB_00943 7.8e-08
HPPHLOHB_00951 2e-08
HPPHLOHB_00955 2.7e-143 spo0M S COG4326 Sporulation control protein
HPPHLOHB_00956 3e-27
HPPHLOHB_00957 5.9e-134 pepE 3.4.11.2, 3.4.13.21 E Belongs to the peptidase S51 family
HPPHLOHB_00958 0.0 thiC 4.1.99.17 H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HPPHLOHB_00959 1.9e-266 ygaK C Berberine and berberine like
HPPHLOHB_00961 3.2e-291 katA 1.11.1.6 P serves to protect cells from the toxic effects of hydrogen peroxide
HPPHLOHB_00962 1.1e-145 ssuB P COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component
HPPHLOHB_00963 1.7e-171 ssuA M Sulfonate ABC transporter
HPPHLOHB_00964 1.5e-147 ssuC P COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component
HPPHLOHB_00965 3.1e-217 ssuD 1.14.14.5 C Catalyzes the desulfonation of aliphatic sulfonates
HPPHLOHB_00967 6e-42 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPPHLOHB_00968 4.1e-78 ygaO
HPPHLOHB_00969 4.4e-29 K Transcriptional regulator
HPPHLOHB_00971 7.9e-114 yhzB S B3/4 domain
HPPHLOHB_00972 2.1e-224 queG 1.17.99.6 C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPPHLOHB_00973 4.4e-177 yhbB S Putative amidase domain
HPPHLOHB_00974 8.2e-87 trmL 2.1.1.207 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
HPPHLOHB_00975 1.2e-109 yhbD K Protein of unknown function (DUF4004)
HPPHLOHB_00976 1.6e-65 yhbE M COG1664 Integral membrane protein CcmA involved in cell shape determination
HPPHLOHB_00977 8.2e-75 yhbF M COG1664 Integral membrane protein CcmA involved in cell shape determination
HPPHLOHB_00978 0.0 prkA T Ser protein kinase
HPPHLOHB_00979 2.5e-225 yhbH S Belongs to the UPF0229 family
HPPHLOHB_00980 2.2e-76 yhbI K DNA-binding transcription factor activity
HPPHLOHB_00981 3.1e-97 yhbJ V COG1566 Multidrug resistance efflux pump
HPPHLOHB_00982 3.1e-271 yhcA EGP Major facilitator Superfamily
HPPHLOHB_00983 1e-98 yhcB 1.6.5.2 S Belongs to the WrbA family
HPPHLOHB_00984 2.8e-37 yhcC
HPPHLOHB_00985 7.8e-55
HPPHLOHB_00986 6.6e-60 yhcF K Transcriptional regulator
HPPHLOHB_00987 1.6e-123 yhcG V ABC transporter, ATP-binding protein
HPPHLOHB_00988 2.6e-166 yhcH V ABC transporter, ATP-binding protein
HPPHLOHB_00989 3.9e-165 yhcI S COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
HPPHLOHB_00990 1e-30 cspB K Cold-shock protein
HPPHLOHB_00991 5.2e-153 metQ M Belongs to the nlpA lipoprotein family
HPPHLOHB_00992 1.2e-197 yhcK 2.7.7.65 T COG2199 FOG GGDEF domain
HPPHLOHB_00993 6.3e-220 ydjN U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
HPPHLOHB_00994 3.7e-44 yhcM
HPPHLOHB_00995 2.1e-68 yhcN S Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
HPPHLOHB_00996 2.5e-167 yhcP
HPPHLOHB_00997 5.2e-100 yhcQ M Spore coat protein
HPPHLOHB_00998 0.0 yhcR 3.1.3.5, 3.1.31.1 F Belongs to the 5'-nucleotidase family
HPPHLOHB_00999 7.6e-106 yhcS 3.4.22.70 M COG3764 Sortase (surface protein transpeptidase)
HPPHLOHB_01000 7.9e-171 rluA 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
HPPHLOHB_01001 9.3e-68 yhcU S Family of unknown function (DUF5365)
HPPHLOHB_01002 9.9e-68 yhcV S COG0517 FOG CBS domain
HPPHLOHB_01003 4.6e-120 yhcW 5.4.2.6 S hydrolase
HPPHLOHB_01004 2.7e-304 yhcX 3.5.1.3 K Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
HPPHLOHB_01005 1.1e-261 yhxA E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPPHLOHB_01006 5.2e-104 glpP K Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HPPHLOHB_01007 1.9e-152 glpF G Belongs to the MIP aquaporin (TC 1.A.8) family
HPPHLOHB_01008 4.6e-293 glpK 2.7.1.30 C Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HPPHLOHB_01009 0.0 glpD 1.1.5.3 C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPPHLOHB_01010 0.0 pmmB 5.4.2.2, 5.4.2.8 G Phosphoglucomutase
HPPHLOHB_01011 5.5e-214 yhcY 2.7.13.3 T Histidine kinase
HPPHLOHB_01012 1.1e-113 yhcZ K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HPPHLOHB_01013 1.4e-84 azr 1.7.1.6 S NADPH-dependent FMN reductase
HPPHLOHB_01014 1.2e-38 yhdB S YhdB-like protein
HPPHLOHB_01015 4.8e-54 yhdC S Protein of unknown function (DUF3889)
HPPHLOHB_01016 7.9e-189 cwlS 3.5.1.28 CBM50 M COG1388 FOG LysM repeat
HPPHLOHB_01017 3.5e-76 nsrR K Transcriptional regulator
HPPHLOHB_01018 8.7e-239 ygxB M Conserved TM helix
HPPHLOHB_01019 2.1e-276 ycgB S Stage V sporulation protein R
HPPHLOHB_01020 5.8e-258 phoB 3.1.3.1 P Belongs to the alkaline phosphatase family
HPPHLOHB_01021 2.5e-141 lytE 3.5.1.28 CBM50 M COG1388 FOG LysM repeat
HPPHLOHB_01022 3.8e-162 citR K Transcriptional regulator
HPPHLOHB_01023 1.4e-206 citA 2.3.3.1 C Belongs to the citrate synthase family
HPPHLOHB_01024 4.9e-162 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HPPHLOHB_01025 3.4e-250 yhdG E amino acid
HPPHLOHB_01026 1.5e-242 yhdH S Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
HPPHLOHB_01027 3.7e-276 ydeL K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
HPPHLOHB_01028 6.9e-77 BH1582 K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HPPHLOHB_01029 8.1e-45 yhdK S Sigma-M inhibitor protein
HPPHLOHB_01030 6.6e-201 yhdL S Sigma factor regulator N-terminal
HPPHLOHB_01031 5.5e-86 sigM K Belongs to the sigma-70 factor family. ECF subfamily
HPPHLOHB_01032 1.5e-191 yhdN C Aldo keto reductase
HPPHLOHB_01033 3e-110 plsC 2.3.1.51 I Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family
HPPHLOHB_01034 3.1e-240 corC1 S COG1253 Hemolysins and related proteins containing CBS domains
HPPHLOHB_01035 4.1e-74 cueR K transcriptional
HPPHLOHB_01036 1.4e-223 yhdR 2.6.1.1 E Aminotransferase
HPPHLOHB_01037 1.1e-240 corC1 P COG1253 Hemolysins and related proteins containing CBS domains
HPPHLOHB_01038 2.8e-47 crcB D Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPPHLOHB_01039 5.1e-66 crcB D Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPPHLOHB_01040 3.3e-135 yhdW 3.1.4.46 C glycerophosphoryl diester phosphodiesterase
HPPHLOHB_01042 6.6e-204 yhdY M Mechanosensitive ion channel
HPPHLOHB_01043 1.2e-140 cobB K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form
HPPHLOHB_01044 1.7e-151 yheN G deacetylase
HPPHLOHB_01045 1.1e-153 dat 2.6.1.21 E Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha- keto acid in the first half-reaction
HPPHLOHB_01046 2.2e-233 nhaC C Na H antiporter
HPPHLOHB_01047 3.4e-84 nhaX T Belongs to the universal stress protein A family
HPPHLOHB_01048 0.0 yheI V COG1132 ABC-type multidrug transport system, ATPase and permease components
HPPHLOHB_01049 0.0 yheH V COG1132 ABC-type multidrug transport system, ATPase and permease components
HPPHLOHB_01050 3.7e-111 yheG GM NAD(P)H-binding
HPPHLOHB_01051 6.3e-28 sspB S spore protein
HPPHLOHB_01052 1.3e-36 yheE S Family of unknown function (DUF5342)
HPPHLOHB_01053 1.6e-268 gshB 6.3.2.2, 6.3.2.3 HJ YheC/D like ATP-grasp
HPPHLOHB_01054 4.3e-216 yheC HJ YheC/D like ATP-grasp
HPPHLOHB_01055 6.7e-204 yheB S Belongs to the UPF0754 family
HPPHLOHB_01056 9.5e-48 yheA S Belongs to the UPF0342 family
HPPHLOHB_01057 3.1e-206 yhaZ L DNA alkylation repair enzyme
HPPHLOHB_01058 4.3e-142 yhaX S haloacid dehalogenase-like hydrolase
HPPHLOHB_01059 7.1e-294 hemZ H coproporphyrinogen III oxidase
HPPHLOHB_01060 1.7e-208 yhaU P COG0475 Kef-type K transport systems, membrane components
HPPHLOHB_01061 7.8e-88 yhaT P regulatory, ligand-binding protein related to C-terminal domains of K channels
HPPHLOHB_01063 1.9e-133 yhaR 5.3.3.18 I enoyl-CoA hydratase
HPPHLOHB_01064 1.1e-26 S YhzD-like protein
HPPHLOHB_01065 1.8e-167 yhaQ S ABC transporter, ATP-binding protein
HPPHLOHB_01066 4.2e-215 yhaP CP COG1668 ABC-type Na efflux pump, permease component
HPPHLOHB_01067 3.6e-227 yhaO L DNA repair exonuclease
HPPHLOHB_01068 0.0 yhaN L AAA domain
HPPHLOHB_01069 1.5e-177 yhaM L Shows a 3'-5' exoribonuclease activity
HPPHLOHB_01070 1.6e-21 yhaL S Sporulation protein YhaL
HPPHLOHB_01071 1.9e-121 prsA 5.2.1.8 M plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins
HPPHLOHB_01072 8.7e-90 yhaK S Putative zincin peptidase
HPPHLOHB_01073 1.3e-54 yhaI S Protein of unknown function (DUF1878)
HPPHLOHB_01074 1e-113 hpr K Negative regulator of protease production and sporulation
HPPHLOHB_01075 7e-39 yhaH S YtxH-like protein
HPPHLOHB_01076 3.6e-80 trpP S Tryptophan transporter TrpP
HPPHLOHB_01077 9.9e-205 serC 2.6.1.52 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HPPHLOHB_01078 4.7e-81 hit FG COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
HPPHLOHB_01079 4.6e-137 ecsA V transporter (ATP-binding protein)
HPPHLOHB_01080 1.8e-215 ecsB U ABC transporter
HPPHLOHB_01081 4.8e-115 ecsC S EcsC protein family
HPPHLOHB_01082 2.3e-231 yhaA 3.5.1.47 E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
HPPHLOHB_01083 4.2e-248 yhfA C membrane
HPPHLOHB_01084 7.5e-17 1.15.1.2 C Rubrerythrin
HPPHLOHB_01085 1.3e-90 traP 1.14.99.57, 6.2.1.3 S enzyme involved in biosynthesis of extracellular polysaccharides
HPPHLOHB_01086 0.0 pbpF 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
HPPHLOHB_01087 1.7e-204 hemE 4.1.1.37 H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HPPHLOHB_01088 7.3e-180 hemH 4.99.1.1, 4.99.1.9 H Catalyzes the ferrous insertion into protoporphyrin IX
HPPHLOHB_01089 1.7e-268 hemG 1.14.19.9, 1.3.3.15, 1.3.3.4 H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HPPHLOHB_01090 1.4e-101 yhgD K Transcriptional regulator
HPPHLOHB_01091 1e-238 yhgE S YhgE Pip N-terminal domain protein
HPPHLOHB_01092 3e-184 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPPHLOHB_01093 9.8e-138 yhfC S Putative membrane peptidase family (DUF2324)
HPPHLOHB_01094 1.6e-199 yhfE 3.2.1.4 GH5,GH9 G peptidase M42
HPPHLOHB_01095 1.7e-72 3.4.13.21 S ASCH
HPPHLOHB_01096 3.8e-227 gltP C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
HPPHLOHB_01097 1.8e-141 yhfI S COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III
HPPHLOHB_01098 2e-191 lplJ 6.3.1.20 H Lipoate-protein ligase
HPPHLOHB_01099 2.6e-112 yhfK GM NmrA-like family
HPPHLOHB_01100 7.3e-302 fadD 6.2.1.3 IQ AMP-binding enzyme C-terminal domain
HPPHLOHB_01101 1.9e-65 yhfM
HPPHLOHB_01102 5.4e-242 yhfN 3.4.24.84 O Peptidase M48
HPPHLOHB_01103 2.3e-204 aprE 3.4.21.62 O Belongs to the peptidase S8 family
HPPHLOHB_01104 9.2e-80 VY92_01935 K acetyltransferase
HPPHLOHB_01105 8.3e-182 yhfP 1.1.1.1 C Quinone oxidoreductase
HPPHLOHB_01106 4.3e-159 yfmC M Periplasmic binding protein
HPPHLOHB_01107 1.9e-109 yhfR 3.1.3.73 G Belongs to the phosphoglycerate mutase family
HPPHLOHB_01108 2.3e-201 vraB 2.3.1.9 I Belongs to the thiolase family
HPPHLOHB_01109 1e-281 yhfT 6.2.1.3 IQ AMP-binding enzyme C-terminal domain
HPPHLOHB_01110 5e-91 bioY S BioY family
HPPHLOHB_01111 1.7e-182 hemAT NT chemotaxis protein
HPPHLOHB_01112 1.1e-302 yhfW CE COG0665 Glycine D-amino acid oxidases (deaminating)
HPPHLOHB_01113 1.6e-157 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HPPHLOHB_01114 1.3e-32 yhzC S IDEAL
HPPHLOHB_01115 4.2e-109 comK K Competence transcription factor
HPPHLOHB_01116 2.1e-168 IQ Enoyl-(Acyl carrier protein) reductase
HPPHLOHB_01117 7.8e-42 yhjA S Excalibur calcium-binding domain
HPPHLOHB_01118 6.1e-266 yhjB E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPPHLOHB_01119 6.9e-27 yhjC S Protein of unknown function (DUF3311)
HPPHLOHB_01120 5e-60 yhjD
HPPHLOHB_01121 9.1e-110 yhjE S SNARE associated Golgi protein
HPPHLOHB_01122 1.2e-91 sipV 3.4.21.89 U Belongs to the peptidase S26 family
HPPHLOHB_01123 1.1e-286 yhjG CH FAD binding domain
HPPHLOHB_01124 1.2e-94 yhjH K helix_turn_helix multiple antibiotic resistance protein
HPPHLOHB_01125 6.9e-215 glcP G Major Facilitator Superfamily
HPPHLOHB_01126 1.1e-200 thuB 1.1.1.361 S Oxidoreductase family, C-terminal alpha/beta domain
HPPHLOHB_01127 1.8e-161 ntdB 3.1.3.92 S Sucrose-6F-phosphate phosphohydrolase
HPPHLOHB_01128 4.4e-255 ntdA 2.6.1.104 E Belongs to the DegT DnrJ EryC1 family
HPPHLOHB_01129 7e-189 yhjM 5.1.1.1 K Transcriptional regulator
HPPHLOHB_01130 3.8e-202 abrB S membrane
HPPHLOHB_01131 3.1e-215 EGP Transmembrane secretion effector
HPPHLOHB_01132 0.0 S Sugar transport-related sRNA regulator N-term
HPPHLOHB_01133 2e-36 yhjQ C COG1145 Ferredoxin
HPPHLOHB_01134 2.2e-78 yhjR S Rubrerythrin
HPPHLOHB_01135 0.0 addB 3.1.21.3, 3.6.4.12 L ATP-dependent helicase deoxyribonuclease subunit B
HPPHLOHB_01136 0.0 addA 3.6.4.12 L ATP-dependent helicase nuclease subunit A
HPPHLOHB_01137 1.7e-221 sbcD L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
HPPHLOHB_01138 0.0 sbcC L COG0419 ATPase involved in DNA repair
HPPHLOHB_01139 6e-51 yisB V COG1403 Restriction endonuclease
HPPHLOHB_01140 4.5e-32 gerPF S Spore germination protein gerPA/gerPF
HPPHLOHB_01141 3e-66 gerPE S Spore germination protein GerPE
HPPHLOHB_01142 6.3e-24 gerPD S Spore germination protein
HPPHLOHB_01143 1.8e-54 gerPC S Spore germination protein
HPPHLOHB_01144 4e-34 gerPB S cell differentiation
HPPHLOHB_01145 1.9e-33 gerPA S Spore germination protein
HPPHLOHB_01146 1.5e-22 yisI S Spo0E like sporulation regulatory protein
HPPHLOHB_01147 1.7e-176 cotH M Spore Coat
HPPHLOHB_01148 3.2e-172 yisK Q COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)
HPPHLOHB_01149 3e-57 yisL S UPF0344 protein
HPPHLOHB_01150 0.0 wprA O Belongs to the peptidase S8 family
HPPHLOHB_01151 7.2e-106 yisN S Protein of unknown function (DUF2777)
HPPHLOHB_01152 0.0 asnO 6.3.5.4 E Asparagine synthase
HPPHLOHB_01153 2.1e-88 yizA S Damage-inducible protein DinB
HPPHLOHB_01154 6.8e-150 crtB 2.5.1.21, 2.5.1.32, 2.5.1.99 I phytoene
HPPHLOHB_01155 4e-243 yisQ V Mate efflux family protein
HPPHLOHB_01156 1.2e-160 yisR K Transcriptional regulator
HPPHLOHB_01157 2.4e-184 purR K helix_turn _helix lactose operon repressor
HPPHLOHB_01158 4.5e-199 yisS 1.1.1.370 S Oxidoreductase family, C-terminal alpha/beta domain
HPPHLOHB_01159 1.3e-93 yisT S DinB family
HPPHLOHB_01160 6.4e-108 argO S Lysine exporter protein LysE YggA
HPPHLOHB_01161 1.7e-281 yisV K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
HPPHLOHB_01162 4e-36 mcbG S Pentapeptide repeats (9 copies)
HPPHLOHB_01163 3.1e-155 yisY I hydrolases or acyltransferases (alpha beta hydrolase superfamily)
HPPHLOHB_01164 4.9e-113 cysC 1.8.4.10, 1.8.4.8, 2.7.1.25, 2.7.7.4 P Catalyzes the synthesis of activated sulfate
HPPHLOHB_01165 3.2e-233 sat 2.7.7.4 P Belongs to the sulfate adenylyltransferase family
HPPHLOHB_01166 9.2e-143 cysH 1.8.4.10, 1.8.4.8, 2.7.1.25 EH Belongs to the PAPS reductase family. CysH subfamily
HPPHLOHB_01167 4.9e-125 comB 3.1.3.71 H Belongs to the ComB family
HPPHLOHB_01168 1.9e-141 yitD 4.4.1.19 S synthase
HPPHLOHB_01169 1.7e-108 yitE S Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPPHLOHB_01170 5.4e-222 yitF 5.5.1.27 M Belongs to the mandelate racemase muconate lactonizing enzyme family
HPPHLOHB_01171 4e-229 yitG EGP Major facilitator Superfamily
HPPHLOHB_01172 1.8e-161 yitH K Acetyltransferase (GNAT) domain
HPPHLOHB_01173 2e-82 yjcF S Acetyltransferase (GNAT) domain
HPPHLOHB_01174 0.0 yitJ 1.5.1.20, 2.1.1.10, 2.1.1.13 E Catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine
HPPHLOHB_01175 8.6e-55 yajQ S Belongs to the UPF0234 family
HPPHLOHB_01176 4e-161 cvfB S protein conserved in bacteria
HPPHLOHB_01177 8.5e-94
HPPHLOHB_01178 2.8e-171
HPPHLOHB_01179 1.5e-97 S Sporulation delaying protein SdpA
HPPHLOHB_01180 1.5e-58 K Transcriptional regulator PadR-like family
HPPHLOHB_01181 2e-95
HPPHLOHB_01182 1.4e-44 yitR S Domain of unknown function (DUF3784)
HPPHLOHB_01183 2.2e-311 nprB 3.4.24.28 E Peptidase M4
HPPHLOHB_01184 8.4e-159 yitS S protein conserved in bacteria
HPPHLOHB_01185 6.6e-148 yitT S Uncharacterized protein conserved in bacteria (DUF2179)
HPPHLOHB_01186 1.9e-72 ipi S Intracellular proteinase inhibitor
HPPHLOHB_01187 1.2e-17 S Protein of unknown function (DUF3813)
HPPHLOHB_01188 1.9e-155 yitU 3.1.3.104 S hydrolases of the HAD superfamily
HPPHLOHB_01189 4.5e-143 yjfP S COG1073 Hydrolases of the alpha beta superfamily
HPPHLOHB_01190 4.7e-51 yitW S metal-sulfur cluster biosynthetic enzyme
HPPHLOHB_01191 1.5e-22 pilT S Proteolipid membrane potential modulator
HPPHLOHB_01192 4.3e-272 yitY C D-arabinono-1,4-lactone oxidase
HPPHLOHB_01193 1.7e-88 norB G Major Facilitator Superfamily
HPPHLOHB_01194 5.4e-200 argC 1.2.1.38 E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPPHLOHB_01195 3.1e-231 argJ 2.3.1.1, 2.3.1.35, 2.7.2.8 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HPPHLOHB_01196 2.2e-137 argB 2.7.2.8 E Belongs to the acetylglutamate kinase family. ArgB subfamily
HPPHLOHB_01197 4.4e-219 argD 2.6.1.11, 2.6.1.17 E acetylornithine aminotransferase
HPPHLOHB_01198 3.9e-206 carA 6.3.5.5 F Carbamoyl-phosphate synthetase glutamine chain
HPPHLOHB_01199 0.0 carB 6.3.5.5 EF Carbamoyl-phosphate synthetase ammonia chain
HPPHLOHB_01200 3.8e-176 argF 2.1.3.3 E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HPPHLOHB_01201 9.5e-28 yjzC S YjzC-like protein
HPPHLOHB_01202 2.3e-16 yjzD S Protein of unknown function (DUF2929)
HPPHLOHB_01203 6.2e-142 yjaU I carboxylic ester hydrolase activity
HPPHLOHB_01204 7.3e-103 yjaV
HPPHLOHB_01205 1.1e-183 med S Transcriptional activator protein med
HPPHLOHB_01206 7.3e-26 comZ S ComZ
HPPHLOHB_01207 2.7e-22 yjzB
HPPHLOHB_01208 3.9e-173 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPPHLOHB_01209 1.8e-234 fabF 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
HPPHLOHB_01210 7.8e-151 yjaZ O Zn-dependent protease
HPPHLOHB_01211 1.8e-184 appD P Belongs to the ABC transporter superfamily
HPPHLOHB_01212 6.5e-187 appF E Belongs to the ABC transporter superfamily
HPPHLOHB_01213 1.6e-251 appA E COG0747 ABC-type dipeptide transport system, periplasmic component
HPPHLOHB_01214 1.3e-171 oppB P COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPPHLOHB_01215 7.9e-163 appC EP COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPPHLOHB_01216 5e-147 yjbA S Belongs to the UPF0736 family
HPPHLOHB_01217 6.1e-185 trpS 6.1.1.2 J Tryptophanyl-tRNA synthetase
HPPHLOHB_01218 0.0 oppA E ABC transporter substrate-binding protein
HPPHLOHB_01219 2.7e-166 oppB P COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPPHLOHB_01220 7.7e-166 oppC EP COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPPHLOHB_01221 3e-198 oppD P Belongs to the ABC transporter superfamily
HPPHLOHB_01222 5.5e-172 oppF E Belongs to the ABC transporter superfamily
HPPHLOHB_01223 8.6e-196 yjbB EGP Major Facilitator Superfamily
HPPHLOHB_01224 6.9e-104 yjbC K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HPPHLOHB_01225 2.1e-67 spxA 1.20.4.1 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
HPPHLOHB_01226 6e-112 yjbE P Integral membrane protein TerC family
HPPHLOHB_01227 2.3e-116 mecA NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC
HPPHLOHB_01228 2.3e-223 yjbF S Competence protein
HPPHLOHB_01229 0.0 pepF E oligoendopeptidase F
HPPHLOHB_01230 1.8e-20
HPPHLOHB_01232 3.3e-169 yjbH Q dithiol-disulfide isomerase involved in polyketide biosynthesis
HPPHLOHB_01233 3.7e-72 yjbI S Bacterial-like globin
HPPHLOHB_01234 1.5e-87 yjbJ M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)
HPPHLOHB_01235 2.4e-101 yjbK S protein conserved in bacteria
HPPHLOHB_01236 7.1e-62 yjbL S Belongs to the UPF0738 family
HPPHLOHB_01237 2.6e-112 yjbM 2.7.6.5 S GTP pyrophosphokinase
HPPHLOHB_01238 2.1e-151 nadK 2.7.1.23 G Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HPPHLOHB_01239 9.5e-161 yjbO 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
HPPHLOHB_01240 3e-128 prpE 3.1.3.16, 3.6.1.41 T Asymmetrically hydrolyzes Ap4p to yield AMP and ATP
HPPHLOHB_01241 0.0 yjbQ P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
HPPHLOHB_01242 3.4e-137 tenA 3.5.99.2 K Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HPPHLOHB_01243 3.8e-108 tenI 2.5.1.3, 5.3.99.10 H Transcriptional regulator TenI
HPPHLOHB_01244 7.2e-219 thiO 1.4.3.19 E Glycine oxidase
HPPHLOHB_01245 3e-30 thiS H thiamine diphosphate biosynthetic process
HPPHLOHB_01246 1.5e-135 thiG 2.8.1.10 H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S
HPPHLOHB_01247 6e-188 thiF 2.7.7.73, 2.7.7.80 H COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
HPPHLOHB_01248 5.3e-150 thiD 2.5.1.3, 2.7.1.35, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Phosphomethylpyrimidine kinase
HPPHLOHB_01249 3.2e-141 fabI 1.3.1.10, 1.3.1.9 I Enoyl- acyl-carrier-protein reductase NADH
HPPHLOHB_01250 5.9e-54 yjbX S Spore coat protein
HPPHLOHB_01251 5.2e-83 cotZ S Spore coat protein
HPPHLOHB_01252 3.4e-96 cotY S Spore coat protein Z
HPPHLOHB_01253 6.4e-77 cotX S Spore Coat Protein X and V domain
HPPHLOHB_01254 3e-32 cotW
HPPHLOHB_01255 2.3e-55 cotV S Spore Coat Protein X and V domain
HPPHLOHB_01256 8.7e-57 yjcA S Protein of unknown function (DUF1360)
HPPHLOHB_01259 2.9e-38 spoVIF S Stage VI sporulation protein F
HPPHLOHB_01260 0.0 yjcD 3.6.4.12 L DNA helicase
HPPHLOHB_01261 1.7e-38
HPPHLOHB_01262 3e-72 yjcF S COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HPPHLOHB_01263 2.9e-93 yjcG J Belongs to the 2H phosphoesterase superfamily. YjcG family
HPPHLOHB_01264 1.8e-138 yjcH P COG2382 Enterochelin esterase and related enzymes
HPPHLOHB_01265 3.8e-215 metB 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
HPPHLOHB_01266 2.9e-218 metC 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
HPPHLOHB_01267 3.7e-99 rimJ 2.3.1.128 J Alanine acetyltransferase
HPPHLOHB_01268 1.1e-212 yjcL S Protein of unknown function (DUF819)
HPPHLOHB_01271 2.1e-190 S Putative amidase domain
HPPHLOHB_01272 2.6e-44 yjcN
HPPHLOHB_01275 8.5e-81 L Transposase
HPPHLOHB_01276 1.6e-72 yjcP
HPPHLOHB_01277 4.1e-49 S YjcQ protein
HPPHLOHB_01278 1.1e-92 yqaS L DNA packaging
HPPHLOHB_01279 2.2e-47 yjcS S Antibiotic biosynthesis monooxygenase
HPPHLOHB_01280 2.4e-141 IQ Enoyl-(Acyl carrier protein) reductase
HPPHLOHB_01282 0.0 manR 2.7.1.200, 2.7.1.202 GKT transcriptional antiterminator
HPPHLOHB_01283 0.0 manP 2.7.1.191, 2.7.1.202 G phosphotransferase system
HPPHLOHB_01284 6.7e-189 manA 5.3.1.8 G mannose-6-phosphate isomerase
HPPHLOHB_01285 4.8e-51 yjdF S Protein of unknown function (DUF2992)
HPPHLOHB_01286 2.5e-94 yjdG 2.3.1.128 J Acetyltransferase (GNAT) domain
HPPHLOHB_01288 8e-82 ybaK S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPPHLOHB_01289 4.2e-29 S Domain of unknown function (DUF4177)
HPPHLOHB_01290 2.7e-52 yjdJ S Domain of unknown function (DUF4306)
HPPHLOHB_01291 3.3e-175 cyoE 2.5.1.141 O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
HPPHLOHB_01293 4.9e-265 xynD 3.5.1.104 G Polysaccharide deacetylase
HPPHLOHB_01294 5.5e-83 S Protein of unknown function (DUF2690)
HPPHLOHB_01295 3.6e-21 yjfB S Putative motility protein
HPPHLOHB_01296 1.6e-171 yjfC O Predicted Zn-dependent protease (DUF2268)
HPPHLOHB_01297 1.2e-45 T PhoQ Sensor
HPPHLOHB_01298 8.9e-104 yjgB S Domain of unknown function (DUF4309)
HPPHLOHB_01299 0.0 yjgC 1.17.1.10, 1.17.1.9 C formate dehydrogenase (NAD+) activity
HPPHLOHB_01300 4.3e-95 yjgD S Protein of unknown function (DUF1641)
HPPHLOHB_01301 8.7e-07 S Domain of unknown function (DUF4352)
HPPHLOHB_01302 2e-117 yjhB 3.6.1.13, 3.6.1.55 F ADP-ribose pyrophosphatase
HPPHLOHB_01304 3.8e-226 yjiB 1.14.13.154, 1.14.15.8 C Cytochrome P450
HPPHLOHB_01305 4.5e-219 oleD GT1 CG COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase
HPPHLOHB_01306 8.2e-30
HPPHLOHB_01307 1.2e-146 hemD 2.1.1.107, 4.2.1.75 H Uroporphyrinogen-III synthase
HPPHLOHB_01308 1.9e-122 ybbM S transport system, permease component
HPPHLOHB_01309 5.2e-136 pstB 3.6.3.27 P ATPases associated with a variety of cellular activities
HPPHLOHB_01310 1.8e-176 yjlA EG Putative multidrug resistance efflux transporter
HPPHLOHB_01311 2.8e-93 yjlB S Cupin domain
HPPHLOHB_01312 7.1e-66 yjlC S Protein of unknown function (DUF1641)
HPPHLOHB_01313 2.6e-219 yjlD 1.6.99.3 C NADH dehydrogenase
HPPHLOHB_01314 6.3e-284 uxaC 5.3.1.12 G glucuronate isomerase
HPPHLOHB_01315 5.8e-250 yjmB G symporter YjmB
HPPHLOHB_01316 3e-195 yjmC 1.1.1.350 C Belongs to the LDH2 MDH2 oxidoreductase family
HPPHLOHB_01317 1.6e-193 rspB 1.1.1.380 E Alcohol dehydrogenase GroES-like domain
HPPHLOHB_01318 4.7e-215 uxuA 4.2.1.8 G Catalyzes the dehydration of D-mannonate
HPPHLOHB_01319 2.3e-153 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
HPPHLOHB_01320 3.7e-227 exuT G Sugar (and other) transporter
HPPHLOHB_01321 2.3e-184 exuR K transcriptional
HPPHLOHB_01322 2.1e-287 uxaB 1.1.1.17, 1.1.1.58 G tagaturonate reductase activity
HPPHLOHB_01323 2e-288 uxaA 4.2.1.7, 4.4.1.24 G Altronate
HPPHLOHB_01324 4.3e-130 MA20_18170 S membrane transporter protein
HPPHLOHB_01325 3.3e-80 yjoA S DinB family
HPPHLOHB_01326 9.4e-247 ftsH2 3.4.21.53 O AAA domain (dynein-related subfamily)
HPPHLOHB_01327 2.1e-213 S response regulator aspartate phosphatase
HPPHLOHB_01329 6.3e-41 S YCII-related domain
HPPHLOHB_01330 9.1e-170 xlyA 3.5.1.28 CBM50 M N-acetylmuramoyl-L-alanine amidase
HPPHLOHB_01331 2.1e-61 yjqA S Bacterial PH domain
HPPHLOHB_01332 4.2e-112 yjqB S Pfam:DUF867
HPPHLOHB_01333 4.4e-160 ydbD P Catalase
HPPHLOHB_01334 1.6e-111 xkdA E IrrE N-terminal-like domain
HPPHLOHB_01335 3.2e-56 xre K Helix-turn-helix XRE-family like proteins
HPPHLOHB_01337 5.9e-157 xkdB K sequence-specific DNA binding
HPPHLOHB_01338 6.4e-119 xkdC L Bacterial dnaA protein
HPPHLOHB_01341 4.6e-10 yqaO S Phage-like element PBSX protein XtrA
HPPHLOHB_01342 4.4e-86 xpf K COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog
HPPHLOHB_01343 4.8e-140 xtmA L phage terminase small subunit
HPPHLOHB_01344 9.6e-255 xtmB S phage terminase, large subunit
HPPHLOHB_01345 5.4e-286 yqbA S portal protein
HPPHLOHB_01346 1.2e-133 yqbD 2.1.1.72 L Putative phage serine protease XkdF
HPPHLOHB_01347 5.8e-169 xkdG S Phage capsid family
HPPHLOHB_01348 5.5e-65 yqbG S Protein of unknown function (DUF3199)
HPPHLOHB_01349 8.7e-65 yqbH S Domain of unknown function (DUF3599)
HPPHLOHB_01350 4.4e-88 xkdI S Bacteriophage HK97-gp10, putative tail-component
HPPHLOHB_01351 1.9e-77 xkdJ
HPPHLOHB_01352 2.5e-256 xkdK S Phage tail sheath C-terminal domain
HPPHLOHB_01353 6.1e-76 xkdM S Phage tail tube protein
HPPHLOHB_01354 1.9e-77 S Phage XkdN-like tail assembly chaperone protein, TAC
HPPHLOHB_01355 0.0 xkdO L Transglycosylase SLT domain
HPPHLOHB_01356 3.7e-122 xkdP S Lysin motif
HPPHLOHB_01357 4.8e-182 yqbQ 3.2.1.96 G NLP P60 protein
HPPHLOHB_01358 2.1e-39 xkdR S Protein of unknown function (DUF2577)
HPPHLOHB_01359 9.6e-71 xkdS S Protein of unknown function (DUF2634)
HPPHLOHB_01360 6e-191 xkdT S Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
HPPHLOHB_01361 4e-104 xkdU S Uncharacterised protein conserved in bacteria (DUF2313)
HPPHLOHB_01362 6.7e-41
HPPHLOHB_01363 0.0
HPPHLOHB_01364 2.6e-55 xkdW S XkdW protein
HPPHLOHB_01365 1.7e-23 xkdX
HPPHLOHB_01366 1.2e-154 xepA
HPPHLOHB_01367 2.8e-39 xhlA S Haemolysin XhlA
HPPHLOHB_01368 9.3e-40 xhlB S SPP1 phage holin
HPPHLOHB_01369 1.2e-163 xlyA 3.5.1.28 M n-acetylmuramoyl-L-alanine amidase
HPPHLOHB_01370 6.7e-23 spoIISB S Stage II sporulation protein SB
HPPHLOHB_01371 1.8e-136 spoIISA S Toxin SpoIISA, type II toxin-antitoxin system
HPPHLOHB_01372 5.8e-175 pit P phosphate transporter
HPPHLOHB_01373 6.9e-110 ykaA P COG1392 Phosphate transport regulator (distant homolog of PhoU)
HPPHLOHB_01374 9.4e-242 steT E amino acid
HPPHLOHB_01375 7.2e-183 mhqA E COG0346 Lactoylglutathione lyase and related lyases
HPPHLOHB_01377 0.0 ykcB M COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HPPHLOHB_01378 1.3e-179 ykcC GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
HPPHLOHB_01380 8.5e-214 htrA 3.4.21.107 O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPPHLOHB_01381 1e-137 proG 1.5.1.2 E Pyrroline-5-carboxylate reductase
HPPHLOHB_01382 7.9e-154 dppA E D-aminopeptidase
HPPHLOHB_01383 1.1e-159 dppB P COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPPHLOHB_01384 3.9e-176 dppC EP COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPPHLOHB_01385 3.4e-191 dppD P Belongs to the ABC transporter superfamily
HPPHLOHB_01386 0.0 dppE E ABC transporter substrate-binding protein
HPPHLOHB_01388 8.1e-179 ykfA 3.4.17.13 V proteins, homologs of microcin C7 resistance protein MccF
HPPHLOHB_01389 3.2e-203 ykfB 5.1.1.20 M Belongs to the mandelate racemase muconate lactonizing enzyme family
HPPHLOHB_01390 5.3e-172 ykfC 3.4.14.13 M COG0791 Cell wall-associated hydrolases (invasion-associated proteins)
HPPHLOHB_01391 7.7e-188 ykfD E Belongs to the ABC transporter superfamily
HPPHLOHB_01392 7.4e-205 pgl 3.1.1.31 G 6-phosphogluconolactonase
HPPHLOHB_01393 5.3e-161 ykgA E Amidinotransferase
HPPHLOHB_01394 1.5e-92 ykhA 3.1.2.20 I Acyl-CoA hydrolase
HPPHLOHB_01395 1e-226 hmp 1.14.12.17 C Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPPHLOHB_01396 1e-07
HPPHLOHB_01397 5.4e-130 ykjA S Protein of unknown function (DUF421)
HPPHLOHB_01398 1e-98 ykkA S Protein of unknown function (DUF664)
HPPHLOHB_01399 1e-98 ykkB 2.3.1.128 J COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
HPPHLOHB_01400 3.5e-55 ykkC P Multidrug resistance protein
HPPHLOHB_01401 1.1e-50 ykkD P Multidrug resistance protein
HPPHLOHB_01402 3.9e-170 purU 2.7.7.72, 3.5.1.10 F Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)
HPPHLOHB_01403 1e-201 proB 2.7.2.11 E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPPHLOHB_01404 2.5e-228 proA 1.2.1.41, 1.2.1.81 E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HPPHLOHB_01405 1.3e-70 ohrA O Organic hydroperoxide resistance protein
HPPHLOHB_01406 3.9e-75 ohrR K COG1846 Transcriptional regulators
HPPHLOHB_01407 8.4e-72 ohrB O Organic hydroperoxide resistance protein
HPPHLOHB_01409 2.8e-87 guaD 3.5.4.12, 3.5.4.3, 3.5.4.33 FJ COG0590 Cytosine adenosine deaminases
HPPHLOHB_01410 0.0 metE 2.1.1.14 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HPPHLOHB_01411 1.7e-176 isp O Belongs to the peptidase S8 family
HPPHLOHB_01412 6.3e-151 T COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
HPPHLOHB_01413 1.8e-136 ykoC P Cobalt transport protein
HPPHLOHB_01414 4.6e-311 P ABC transporter, ATP-binding protein
HPPHLOHB_01415 6.9e-99 ykoE S ABC-type cobalt transport system, permease component
HPPHLOHB_01416 7.9e-111 ykoF S YKOF-related Family
HPPHLOHB_01417 2.4e-124 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HPPHLOHB_01418 9.4e-245 ykoH 2.7.13.3 T Histidine kinase
HPPHLOHB_01419 1.1e-113 ykoI S Peptidase propeptide and YPEB domain
HPPHLOHB_01420 4.4e-86 ykoJ S Peptidase propeptide and YPEB domain
HPPHLOHB_01423 2.2e-222 mgtE P Acts as a magnesium transporter
HPPHLOHB_01424 1.4e-53 tnrA K transcriptional
HPPHLOHB_01425 5.9e-18
HPPHLOHB_01426 6.9e-26 ykoL
HPPHLOHB_01427 1.3e-81 mhqR K transcriptional
HPPHLOHB_01428 2.3e-220 ugtP 2.4.1.315 GT28 M COG0707 UDP-N-acetylglucosamine LPS N-acetylglucosamine transferase
HPPHLOHB_01429 3.7e-99 ykoP G polysaccharide deacetylase
HPPHLOHB_01430 7.1e-155 ykoQ S Calcineurin-like phosphoesterase superfamily domain
HPPHLOHB_01431 0.0 ykoS
HPPHLOHB_01432 2.5e-186 ykoT GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
HPPHLOHB_01433 0.0 ligD 6.5.1.1 L ATP-dependent DNA ligase
HPPHLOHB_01434 3.2e-161 ku L With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HPPHLOHB_01435 0.0 ydcR 2.7.7.65 T Diguanylate cyclase
HPPHLOHB_01436 1.4e-116 ykoX S membrane-associated protein
HPPHLOHB_01437 2.1e-177 ykoY P COG0861 Membrane protein TerC, possibly involved in tellurium resistance
HPPHLOHB_01438 9.5e-130 sigI K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPPHLOHB_01439 8.2e-117 rsgI S Anti-sigma factor N-terminus
HPPHLOHB_01440 1.9e-26 sspD S small acid-soluble spore protein
HPPHLOHB_01441 1.5e-124 ykrK S Domain of unknown function (DUF1836)
HPPHLOHB_01442 7e-156 htpX O Belongs to the peptidase M48B family
HPPHLOHB_01443 1.7e-233 ktrB P COG0168 Trk-type K transport systems, membrane components
HPPHLOHB_01444 1.2e-10 ydfR S Protein of unknown function (DUF421)
HPPHLOHB_01445 4.5e-22 ykzE
HPPHLOHB_01446 6.5e-190 ykrP G COG3594 Fucose 4-O-acetylase and related acetyltransferases
HPPHLOHB_01447 0.0 kinE 2.7.13.3 T Histidine kinase
HPPHLOHB_01448 7e-89 ogt 2.1.1.63 L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPPHLOHB_01450 3.3e-197 mtnA 5.3.1.23 E Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HPPHLOHB_01451 7.5e-230 mtnK 2.7.1.100 F Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HPPHLOHB_01452 3.5e-151 mtnU 3.5.1.3 S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
HPPHLOHB_01453 8e-232 mtnE 2.6.1.83 E Aminotransferase
HPPHLOHB_01454 4.1e-231 mtnW 5.3.2.5 G Catalyzes the enolization of 2,3-diketo-5- methylthiopentyl-1-phosphate (DK-MTP-1-P) into 2-hydroxy-3-keto-5- methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P)
HPPHLOHB_01455 7.5e-137 mtnX 3.1.3.87, 4.2.1.109 E Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HPPHLOHB_01456 7.2e-115 mtnB 3.1.3.87, 4.1.2.17, 4.2.1.109, 5.1.3.4 E Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P)
HPPHLOHB_01457 1.3e-96 mtnD 1.13.11.53, 1.13.11.54 S Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HPPHLOHB_01458 1.3e-51 XK27_09985 S Protein of unknown function (DUF1232)
HPPHLOHB_01459 6.4e-09 S Spo0E like sporulation regulatory protein
HPPHLOHB_01460 1.4e-64 eag
HPPHLOHB_01461 2.5e-275 kinD 2.7.13.3 T COG0642 Signal transduction histidine kinase
HPPHLOHB_01462 1.3e-75 ykvE K transcriptional
HPPHLOHB_01463 2.5e-125 motB N Flagellar motor protein
HPPHLOHB_01464 2.7e-138 motA N flagellar motor
HPPHLOHB_01465 0.0 clpE O Belongs to the ClpA ClpB family
HPPHLOHB_01466 8.7e-182 ykvI S membrane
HPPHLOHB_01467 7.3e-126 queC 6.3.4.20 F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HPPHLOHB_01468 2.8e-81 queD 4.1.2.50, 4.2.3.12 H synthase
HPPHLOHB_01469 1.3e-139 queE 1.97.1.4, 4.3.99.3 H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
HPPHLOHB_01470 2e-96 queF 1.7.1.13 S Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPPHLOHB_01471 2e-61 ykvN K Transcriptional regulator
HPPHLOHB_01472 8.2e-134 IQ Enoyl-(Acyl carrier protein) reductase
HPPHLOHB_01473 3.1e-130 ykvP 3.5.1.28 M Glycosyl transferases group 1
HPPHLOHB_01474 2.7e-76 ykvP 3.5.1.28 M Glycosyl transferases group 1
HPPHLOHB_01475 1.2e-35 3.5.1.104 M LysM domain
HPPHLOHB_01476 8.5e-133 G Glycosyl hydrolases family 18
HPPHLOHB_01477 5.6e-46 ykvR S Protein of unknown function (DUF3219)
HPPHLOHB_01478 6e-25 ykvS S protein conserved in bacteria
HPPHLOHB_01479 2.8e-28
HPPHLOHB_01480 1.7e-103 ykvT 3.5.1.28 M Cell Wall Hydrolase
HPPHLOHB_01481 9.9e-239 ykvU S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
HPPHLOHB_01482 4.9e-90 stoA CO thiol-disulfide
HPPHLOHB_01483 0.0 cadA 3.6.3.3, 3.6.3.5 P COG2217 Cation transport ATPase
HPPHLOHB_01484 3.8e-09
HPPHLOHB_01485 8.7e-209 pepQ 3.4.13.9 E COG0006 Xaa-Pro aminopeptidase
HPPHLOHB_01487 9.8e-180 ykvZ 5.1.1.1 K Transcriptional regulator
HPPHLOHB_01489 4.5e-128 glcT K antiterminator
HPPHLOHB_01490 0.0 ptsG 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
HPPHLOHB_01491 2.1e-39 ptsH G phosphocarrier protein HPr
HPPHLOHB_01492 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPPHLOHB_01493 7.2e-39 splA S Transcriptional regulator
HPPHLOHB_01494 2.6e-202 splB 4.1.99.14 L Spore photoproduct lyase
HPPHLOHB_01495 1.2e-131 ykwB 2.3.1.1 K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HPPHLOHB_01496 2e-264 mcpC NT chemotaxis protein
HPPHLOHB_01497 5e-159 glxR 1.1.1.31, 1.1.1.60 I COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases
HPPHLOHB_01498 8e-124 ykwD J protein with SCP PR1 domains
HPPHLOHB_01499 0.0 mrdA 3.4.16.4 M Penicillin-binding Protein
HPPHLOHB_01500 0.0 pilS 2.7.13.3 T Histidine kinase
HPPHLOHB_01501 8e-224 patA 2.6.1.1 E Aminotransferase
HPPHLOHB_01502 2.2e-15
HPPHLOHB_01503 1.6e-168 cheV 2.7.13.3 T Chemotaxis protein CheV
HPPHLOHB_01504 1.7e-84 ykyB S YkyB-like protein
HPPHLOHB_01505 1.6e-238 ykuC EGP Major facilitator Superfamily
HPPHLOHB_01506 4.6e-88 ykuD S protein conserved in bacteria
HPPHLOHB_01507 9.4e-166 ykuE S Metallophosphoesterase
HPPHLOHB_01508 2.2e-142 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HPPHLOHB_01509 0.0 3.2.1.132 M Putative peptidoglycan binding domain
HPPHLOHB_01510 1.7e-93 M Peptidoglycan-binding domain 1 protein
HPPHLOHB_01512 5.2e-234 ykuI T Diguanylate phosphodiesterase
HPPHLOHB_01513 3.9e-37 ykuJ S protein conserved in bacteria
HPPHLOHB_01514 4.4e-94 ykuK S Ribonuclease H-like
HPPHLOHB_01515 3.9e-27 ykzF S Antirepressor AbbA
HPPHLOHB_01516 1.6e-76 ykuL S CBS domain
HPPHLOHB_01517 3.5e-168 ccpC K Transcriptional regulator
HPPHLOHB_01518 5.7e-88 fld C Flavodoxin domain
HPPHLOHB_01519 3.2e-177 ykuO
HPPHLOHB_01520 3.2e-80 fld C Flavodoxin
HPPHLOHB_01521 1.1e-74 dapD 2.3.1.117, 2.3.1.89 E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
HPPHLOHB_01522 5.8e-216 hipO 3.5.1.47 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
HPPHLOHB_01523 9e-37 ykuS S Belongs to the UPF0180 family
HPPHLOHB_01524 8.8e-142 ykuT M Mechanosensitive ion channel
HPPHLOHB_01525 3.9e-101 ykuU O Alkyl hydroperoxide reductase
HPPHLOHB_01526 4.4e-82 ykuV CO thiol-disulfide
HPPHLOHB_01527 5.8e-95 rok K Repressor of ComK
HPPHLOHB_01528 2.9e-147 yknT
HPPHLOHB_01529 3.9e-110 mobA 2.7.7.77 H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
HPPHLOHB_01530 5.3e-192 moeB 2.7.7.73, 2.7.7.80 H COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
HPPHLOHB_01531 8.1e-246 moeA 2.10.1.1 H molybdopterin
HPPHLOHB_01532 9.9e-94 mobB 2.10.1.1, 2.7.7.77 H molybdopterin-guanine dinucleotide biosynthesis protein
HPPHLOHB_01533 8.5e-84 moaE 2.8.1.12 H COG0314 Molybdopterin converting factor, large subunit
HPPHLOHB_01534 2.8e-32 moaD 2.8.1.12 H Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HPPHLOHB_01535 0.0 yknU V COG1132 ABC-type multidrug transport system, ATPase and permease components
HPPHLOHB_01536 0.0 yknV V COG1132 ABC-type multidrug transport system, ATPase and permease components
HPPHLOHB_01537 1e-117 yknW S Yip1 domain
HPPHLOHB_01538 3e-159 acrA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPPHLOHB_01539 2.5e-124 macB V ABC transporter, ATP-binding protein
HPPHLOHB_01540 2.1e-211 yknZ V COG0577 ABC-type antimicrobial peptide transport system, permease component
HPPHLOHB_01541 3.1e-136 fruR K Transcriptional regulator
HPPHLOHB_01542 6.2e-168 fruK 2.7.1.11, 2.7.1.56 G Belongs to the carbohydrate kinase PfkB family
HPPHLOHB_01543 0.0 fruA 2.7.1.202 GT COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type)
HPPHLOHB_01544 4.8e-105 sipT 3.4.21.89 U Belongs to the peptidase S26 family
HPPHLOHB_01545 8.1e-39 ykoA
HPPHLOHB_01546 5.8e-310 ybiT S COG0488 ATPase components of ABC transporters with duplicated ATPase domains
HPPHLOHB_01547 1.5e-169 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPPHLOHB_01548 2e-238 ampS E COG2309 Leucyl aminopeptidase (aminopeptidase T)
HPPHLOHB_01549 1.1e-12 S Uncharacterized protein YkpC
HPPHLOHB_01550 7.7e-183 mreB D Rod-share determining protein MreBH
HPPHLOHB_01551 1.5e-43 abrB K of stationary sporulation gene expression
HPPHLOHB_01552 2.7e-241 kinC 2.7.13.3 T COG0642 Signal transduction histidine kinase
HPPHLOHB_01553 1.6e-162 ykqA P Gamma-glutamyl cyclotransferase, AIG2-like
HPPHLOHB_01554 4e-116 ktrA P COG0569 K transport systems, NAD-binding component
HPPHLOHB_01555 0.0 ade 3.5.4.2 F Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HPPHLOHB_01556 0.0 rnjA S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HPPHLOHB_01557 8.2e-31 ykzG S Belongs to the UPF0356 family
HPPHLOHB_01558 1.4e-147 ykrA S hydrolases of the HAD superfamily
HPPHLOHB_01559 4e-101 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
HPPHLOHB_01561 2e-115 recN L Putative cell-wall binding lipoprotein
HPPHLOHB_01562 9.9e-192 pdhA 1.2.4.1, 1.2.4.4 C COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
HPPHLOHB_01563 2.9e-179 pdhB 1.2.4.1, 1.2.4.4 C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
HPPHLOHB_01564 9.9e-231 pdhC 2.3.1.12 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
HPPHLOHB_01565 2.4e-243 lpdA 1.8.1.4 C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
HPPHLOHB_01566 1.3e-63 slp CO COG0526, thiol-disulfide isomerase and thioredoxins
HPPHLOHB_01567 3.5e-277 speA 4.1.1.19 E Arginine
HPPHLOHB_01568 1.6e-42 yktA S Belongs to the UPF0223 family
HPPHLOHB_01569 7.1e-118 yktB S Belongs to the UPF0637 family
HPPHLOHB_01570 7.1e-26 ykzI
HPPHLOHB_01571 4.6e-151 suhB 3.1.3.25 G Inositol monophosphatase
HPPHLOHB_01572 6.9e-78 ykzC S Acetyltransferase (GNAT) family
HPPHLOHB_01573 6.5e-173 Q Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HPPHLOHB_01574 2.2e-293 mpl 3.4.24.28, 3.4.24.29 E Peptidase M4
HPPHLOHB_01575 0.0 ylaA
HPPHLOHB_01576 2.7e-42 ylaB
HPPHLOHB_01577 2.7e-91 ylaC K Belongs to the sigma-70 factor family. ECF subfamily
HPPHLOHB_01578 1.2e-11 sigC S Putative zinc-finger
HPPHLOHB_01579 1.8e-38 ylaE
HPPHLOHB_01580 8.2e-22 S Family of unknown function (DUF5325)
HPPHLOHB_01581 0.0 typA T GTP-binding protein TypA
HPPHLOHB_01582 4.2e-47 ylaH S YlaH-like protein
HPPHLOHB_01583 2.5e-32 ylaI S protein conserved in bacteria
HPPHLOHB_01584 1.1e-89 ylaJ S Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
HPPHLOHB_01585 8e-249 phoH T ATPase related to phosphate starvation-inducible protein PhoH
HPPHLOHB_01586 2.7e-85 ylaL S Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HPPHLOHB_01587 1.6e-171 glsA 3.5.1.2 E Belongs to the glutaminase family
HPPHLOHB_01588 8.7e-44 ylaN S Belongs to the UPF0358 family
HPPHLOHB_01589 4.5e-214 ftsW D Belongs to the SEDS family
HPPHLOHB_01590 0.0 pyc 6.4.1.1 C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HPPHLOHB_01591 2.6e-166 ctaA 2.5.1.141 O Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group
HPPHLOHB_01592 3.2e-164 ctaB 2.5.1.141 O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
HPPHLOHB_01593 6.2e-191 ctaC 1.9.3.1 C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)
HPPHLOHB_01594 0.0 ctaD 1.10.3.12, 1.9.3.1 C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPPHLOHB_01595 3.3e-112 cyoC 1.10.3.12, 1.9.3.1 C COG1845 Heme copper-type cytochrome quinol oxidase, subunit 3
HPPHLOHB_01596 4.2e-53 ctaF 1.10.3.12, 1.9.3.1 C COG3125 Heme copper-type cytochrome quinol oxidase, subunit 4
HPPHLOHB_01597 3e-167 ctaG S cytochrome c oxidase
HPPHLOHB_01598 7e-62 ylbA S YugN-like family
HPPHLOHB_01599 2.6e-74 ylbB T COG0517 FOG CBS domain
HPPHLOHB_01600 3e-201 ylbC S protein with SCP PR1 domains
HPPHLOHB_01601 4.1e-63 ylbD S Putative coat protein
HPPHLOHB_01602 6.7e-37 ylbE S YlbE-like protein
HPPHLOHB_01603 1.8e-75 ylbF S Belongs to the UPF0342 family
HPPHLOHB_01604 7.5e-39 ylbG S UPF0298 protein
HPPHLOHB_01605 1.9e-98 rsmD 2.1.1.171 L Methyltransferase
HPPHLOHB_01606 3.9e-84 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPPHLOHB_01607 3.8e-221 ylbJ S Sporulation integral membrane protein YlbJ
HPPHLOHB_01608 7.5e-138 ylbK S esterase of the alpha-beta hydrolase superfamily
HPPHLOHB_01609 6.8e-187 ylbL T Belongs to the peptidase S16 family
HPPHLOHB_01610 2.8e-235 ylbM S Belongs to the UPF0348 family
HPPHLOHB_01612 1.3e-90 yceD S metal-binding, possibly nucleic acid-binding protein
HPPHLOHB_01613 1.2e-27 rpmF J Belongs to the bacterial ribosomal protein bL32 family
HPPHLOHB_01614 6.8e-75 ylbO S SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
HPPHLOHB_01615 4e-89 ylbP K n-acetyltransferase
HPPHLOHB_01616 7.3e-169 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPPHLOHB_01617 2.9e-309 bshC S Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HPPHLOHB_01618 2.9e-78 mraZ K Belongs to the MraZ family
HPPHLOHB_01619 6.6e-173 rsmH 2.1.1.199 J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
HPPHLOHB_01620 3.7e-44 ftsL D Essential cell division protein
HPPHLOHB_01621 0.0 ftsI 3.4.16.4 M Penicillin-binding Protein
HPPHLOHB_01622 0.0 ftsI 3.4.16.4 M stage V sporulation protein D
HPPHLOHB_01623 5.2e-281 murE 6.3.2.10, 6.3.2.13 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPPHLOHB_01624 3.2e-170 mraY 2.7.8.13 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPPHLOHB_01625 2.6e-255 murD 6.3.2.9 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPPHLOHB_01626 5.7e-186 spoVE D Belongs to the SEDS family
HPPHLOHB_01627 2.3e-201 murG 2.4.1.227, 6.3.2.8 GT28 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPPHLOHB_01628 5.3e-167 murB 1.3.1.98 M cell wall formation
HPPHLOHB_01629 2.6e-138 divIB D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
HPPHLOHB_01630 2.4e-103 ylxW S protein conserved in bacteria
HPPHLOHB_01631 1e-102 ylxX S protein conserved in bacteria
HPPHLOHB_01632 6.2e-58 sbp S small basic protein
HPPHLOHB_01633 2.4e-229 ftsA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
HPPHLOHB_01634 2e-203 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPPHLOHB_01635 0.0 bpr O COG1404 Subtilisin-like serine proteases
HPPHLOHB_01636 4.4e-172 spoIIGA M aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR
HPPHLOHB_01637 1.4e-125 sigE K sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPPHLOHB_01638 3.6e-140 sigG K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPPHLOHB_01639 1.1e-147 modF 3.6.3.21, 3.6.3.34 P COG1119 ABC-type molybdenum transport system, ATPase component photorepair protein PhrA
HPPHLOHB_01640 1.3e-256 argE 3.5.1.16 E Acetylornithine deacetylase
HPPHLOHB_01641 2.4e-37 ylmC S sporulation protein
HPPHLOHB_01642 1.1e-158 yfiH S Belongs to the multicopper oxidase YfiH RL5 family
HPPHLOHB_01643 2.9e-125 ylmE S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPPHLOHB_01644 1.4e-62 sepF D Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
HPPHLOHB_01645 1.3e-39 yggT S membrane
HPPHLOHB_01646 6.7e-139 ylmH 5.4.99.23, 5.4.99.24 S conserved protein, contains S4-like domain
HPPHLOHB_01647 2.6e-67 divIVA D Cell division initiation protein
HPPHLOHB_01648 0.0 ileS 6.1.1.5 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HPPHLOHB_01649 1.3e-63 dksA T COG1734 DnaK suppressor protein
HPPHLOHB_01650 1.8e-78 lspA 3.4.23.36 MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPPHLOHB_01651 1.1e-164 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
HPPHLOHB_01652 2.7e-94 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HPPHLOHB_01653 9e-232 pyrP F Xanthine uracil
HPPHLOHB_01654 1.4e-167 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
HPPHLOHB_01655 1.7e-251 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
HPPHLOHB_01656 5e-212 carA 6.3.5.5 F Carbamoyl-phosphate synthetase glutamine chain
HPPHLOHB_01657 0.0 carB 6.3.5.5 F Belongs to the CarB family
HPPHLOHB_01658 4.8e-145 pyrK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )
HPPHLOHB_01659 2.9e-176 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
HPPHLOHB_01660 8e-126 pyrF 4.1.1.23 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
HPPHLOHB_01661 2.9e-116 pyrE 2.4.2.10, 4.1.1.23 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPPHLOHB_01663 3.5e-142 cysH 1.8.4.10, 1.8.4.8, 2.7.1.25 EH Belongs to the PAPS reductase family. CysH subfamily
HPPHLOHB_01664 1.1e-179 cysP P phosphate transporter
HPPHLOHB_01665 1.3e-223 sat 2.7.7.4 P Belongs to the sulfate adenylyltransferase family
HPPHLOHB_01666 7.3e-109 cysC 2.7.1.25 P Catalyzes the synthesis of activated sulfate
HPPHLOHB_01667 2.2e-145 hemD 2.1.1.107, 4.2.1.75 H Belongs to the precorrin methyltransferase family
HPPHLOHB_01668 2e-146 cbiX 4.99.1.3, 4.99.1.4, 5.4.99.60, 5.4.99.61 S Sirohydrochlorin ferrochelatase
HPPHLOHB_01669 4.3e-83 cysG 1.3.1.76, 4.99.1.4 H Siroheme synthase
HPPHLOHB_01670 0.0 FbpA K RNA-binding protein homologous to eukaryotic snRNP
HPPHLOHB_01671 0.0 yloB 3.6.3.8 P COG0474 Cation transport ATPase
HPPHLOHB_01672 2.4e-156 yloC S stress-induced protein
HPPHLOHB_01673 1.5e-40 ylzA S Belongs to the UPF0296 family
HPPHLOHB_01674 3.1e-110 gmk 2.7.4.8 F Essential for recycling GMP and indirectly, cGMP
HPPHLOHB_01675 2.2e-28 rpoZ 2.7.7.6 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
HPPHLOHB_01676 8.8e-226 coaBC 4.1.1.36, 6.3.2.5 H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPPHLOHB_01677 0.0 priA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPPHLOHB_01678 6e-85 def 2.1.2.9, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
HPPHLOHB_01679 3.8e-176 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPPHLOHB_01680 2.9e-254 sun 2.1.1.176 J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPPHLOHB_01681 4.8e-207 rlmN 2.1.1.192 J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HPPHLOHB_01682 2.4e-141 stp 3.1.3.16 T phosphatase
HPPHLOHB_01683 0.0 prkC 2.7.11.1 KLT serine threonine protein kinase
HPPHLOHB_01684 8.6e-170 rsgA 3.1.3.100 S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
HPPHLOHB_01685 4.2e-118 rpe 5.1.3.1 G Belongs to the ribulose-phosphate 3-epimerase family
HPPHLOHB_01686 3.1e-121 thiN 2.7.6.2 H thiamine pyrophosphokinase
HPPHLOHB_01687 4.2e-26 rpmB J Belongs to the bacterial ribosomal protein bL28 family
HPPHLOHB_01688 5.5e-59 asp S protein conserved in bacteria
HPPHLOHB_01689 2.7e-302 yloV S kinase related to dihydroxyacetone kinase
HPPHLOHB_01690 1.9e-118 sdaAB 4.3.1.17 E L-serine dehydratase
HPPHLOHB_01691 9.3e-156 sdaAA 4.3.1.17 E L-serine dehydratase
HPPHLOHB_01692 0.0 recG 3.6.4.12 L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPPHLOHB_01693 4e-80 fapR 5.3.1.23 K Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism
HPPHLOHB_01694 4.3e-178 plsX 2.3.1.15 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
HPPHLOHB_01695 9.1e-170 fabD 2.3.1.39 I malonyl CoA-acyl carrier protein transacylase
HPPHLOHB_01696 6.1e-129 IQ reductase
HPPHLOHB_01697 2.8e-32 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPPHLOHB_01698 1.2e-135 rnc 3.1.26.3 J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
HPPHLOHB_01699 0.0 smc D Required for chromosome condensation and partitioning
HPPHLOHB_01700 8.8e-176 ftsY U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HPPHLOHB_01701 2.9e-87
HPPHLOHB_01702 1.6e-49 ylxM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HPPHLOHB_01703 6e-236 ffh 3.6.5.4 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPPHLOHB_01704 1.1e-43 rpsP J Belongs to the bacterial ribosomal protein bS16 family
HPPHLOHB_01705 1.2e-36 ylqC S Belongs to the UPF0109 family
HPPHLOHB_01706 1.3e-61 ylqD S YlqD protein
HPPHLOHB_01707 5.3e-95 rimM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HPPHLOHB_01708 9.2e-138 trmD 2.1.1.228, 4.6.1.12 J Belongs to the RNA methyltransferase TrmD family
HPPHLOHB_01709 1.4e-56 rplS J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
HPPHLOHB_01710 4.2e-158 ylqF S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HPPHLOHB_01711 4.1e-136 rnhB 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPPHLOHB_01712 8.5e-291 ylqG
HPPHLOHB_01713 3e-44 ylqH S homolog of the cytoplasmic domain of flagellar protein FhlB
HPPHLOHB_01714 3.4e-211 sucC 6.2.1.5 C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
HPPHLOHB_01715 1.1e-167 sucD 6.2.1.5 C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HPPHLOHB_01716 1.7e-170 dprA LU Rossmann fold nucleotide-binding protein involved in DNA uptake
HPPHLOHB_01717 0.0 topA 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPPHLOHB_01718 7.4e-247 trmFO 2.1.1.74 J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HPPHLOHB_01719 2.5e-169 xerC L tyrosine recombinase XerC
HPPHLOHB_01720 4.4e-92 hslV 3.4.25.2 O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HPPHLOHB_01721 1.5e-250 hslU O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HPPHLOHB_01722 9.2e-136 codY K DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HPPHLOHB_01723 2.3e-63 flgB N Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body
HPPHLOHB_01724 6.9e-75 flgC N Belongs to the flagella basal body rod proteins family
HPPHLOHB_01725 1.9e-31 fliE N Flagellar hook-basal body
HPPHLOHB_01726 7.2e-29 fliF N The M ring may be actively involved in energy transduction
HPPHLOHB_01727 8.5e-217 fliF N The M ring may be actively involved in energy transduction
HPPHLOHB_01728 2e-178 fliG N One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation
HPPHLOHB_01729 2.5e-106 fliH NU COG1317 Flagellar biosynthesis type III secretory pathway protein
HPPHLOHB_01730 2.5e-242 fliI 3.6.3.14 NU COG1157 Flagellar biosynthesis type III secretory pathway ATPase
HPPHLOHB_01731 1.5e-69 fliJ N Flagellar biosynthesis chaperone
HPPHLOHB_01732 7.7e-37 ylxF S MgtE intracellular N domain
HPPHLOHB_01733 1.2e-221 fliK N Flagellar hook-length control protein
HPPHLOHB_01734 1.7e-72 flgD N Flagellar basal body rod modification protein
HPPHLOHB_01735 8.2e-140 flgG N Flagellar basal body rod
HPPHLOHB_01736 4.6e-49 fliL N Controls the rotational direction of flagella during chemotaxis
HPPHLOHB_01737 1.9e-181 fliM N One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation
HPPHLOHB_01738 4.5e-184 fliN N FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPPHLOHB_01739 1.6e-58 cheB 3.1.1.61, 3.5.1.44 T response regulator
HPPHLOHB_01740 9.3e-97 fliZ N Flagellar biosynthesis protein, FliO
HPPHLOHB_01741 1.6e-109 fliP N Plays a role in the flagellum-specific transport system
HPPHLOHB_01742 2.2e-36 fliQ N Role in flagellar biosynthesis
HPPHLOHB_01743 3.6e-132 fliR N Flagellar biosynthetic protein FliR
HPPHLOHB_01744 1.4e-190 flhB N Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPPHLOHB_01745 0.0 flhA N Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPPHLOHB_01746 5.2e-201 flhF N Flagellar biosynthesis regulator FlhF
HPPHLOHB_01747 7.5e-158 flhG D Belongs to the ParA family
HPPHLOHB_01748 5.8e-197 cheB 3.1.1.61, 3.5.1.44 NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR
HPPHLOHB_01749 0.0 cheA 2.7.13.3 NT COG0643 Chemotaxis protein histidine kinase and related kinases
HPPHLOHB_01750 2.8e-79 cheW NT COG0835 Chemotaxis signal transduction protein
HPPHLOHB_01751 1.3e-111 cheC NT COG1776 Chemotaxis protein CheC, inhibitor of MCP methylation
HPPHLOHB_01752 1.1e-86 cheD 3.5.1.44 NT Deamidates glutamine residues to glutamate on methyl- accepting chemotaxis receptors (MCPs). CheD-mediated MCP deamidation is required for productive communication of the conformational signals of the chemoreceptors to the CheA kinase
HPPHLOHB_01753 5.6e-138 sigD K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPPHLOHB_01754 4.3e-78 ylxL
HPPHLOHB_01755 1e-131 rpsB J Belongs to the universal ribosomal protein uS2 family
HPPHLOHB_01756 6.3e-157 tsf J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HPPHLOHB_01757 2.7e-126 pyrH 2.7.4.22 F Catalyzes the reversible phosphorylation of UMP to UDP
HPPHLOHB_01758 6.4e-91 frr J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
HPPHLOHB_01759 8.3e-145 uppS 2.5.1.31 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPPHLOHB_01760 1.2e-138 cdsA 2.7.7.41 S Belongs to the CDS family
HPPHLOHB_01761 4.6e-216 dxr 1.1.1.267 I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
HPPHLOHB_01762 7.7e-233 rasP M zinc metalloprotease
HPPHLOHB_01763 0.0 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
HPPHLOHB_01764 0.0 polC 2.7.7.7 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPPHLOHB_01765 3.3e-80 rimP S Required for maturation of 30S ribosomal subunits
HPPHLOHB_01766 1.1e-203 nusA K Participates in both transcription termination and antitermination
HPPHLOHB_01767 3.4e-32 ylxR K nucleic-acid-binding protein implicated in transcription termination
HPPHLOHB_01768 3.1e-47 ylxQ J ribosomal protein
HPPHLOHB_01769 0.0 infB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPPHLOHB_01770 3e-44 ylxP S protein conserved in bacteria
HPPHLOHB_01771 5e-57 rbfA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HPPHLOHB_01772 1.3e-173 truB 5.4.99.25 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HPPHLOHB_01773 6.1e-182 ribF 2.7.1.26, 2.7.7.2 H Belongs to the ribF family
HPPHLOHB_01774 6e-42 rpsO J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HPPHLOHB_01775 0.0 pnp 2.7.7.8 J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
HPPHLOHB_01776 4.2e-183 ylxY 3.5.1.104 G Sporulation protein, polysaccharide deacetylase
HPPHLOHB_01777 4.4e-233 pepR S Belongs to the peptidase M16 family
HPPHLOHB_01778 2.6e-42 ymxH S YlmC YmxH family
HPPHLOHB_01779 2.9e-162 spoVFA 1.1.1.29, 1.1.1.399, 1.1.1.95 CH Dipicolinate synthase subunit A
HPPHLOHB_01780 4.3e-109 spoVFB H Together with DpaA, catalyzes the conversion of dihydrodipicolinate to dipicolinate (DPA)
HPPHLOHB_01781 1.4e-192 asd 1.2.1.11 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPPHLOHB_01782 5.9e-222 dapG 1.1.1.3, 2.7.2.4 E Belongs to the aspartokinase family
HPPHLOHB_01783 1.4e-156 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPPHLOHB_01784 1.9e-308 rnjB S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HPPHLOHB_01785 5.3e-133 tepA 3.4.21.92 OU COG0740 Protease subunit of ATP-dependent Clp proteases
HPPHLOHB_01786 4.4e-32 S YlzJ-like protein
HPPHLOHB_01787 0.0 ftsK D Belongs to the FtsK SpoIIIE SftA family
HPPHLOHB_01788 1.4e-133 ymfC K Transcriptional regulator
HPPHLOHB_01789 1.5e-206 ymfD EGP Major facilitator Superfamily
HPPHLOHB_01790 2.6e-236 ymfF S Peptidase M16
HPPHLOHB_01791 1.4e-242 ymfH S zinc protease
HPPHLOHB_01792 9.2e-130 ymfI 1.1.1.100, 1.3.1.28 S Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
HPPHLOHB_01793 4.8e-41 ymfJ S Protein of unknown function (DUF3243)
HPPHLOHB_01794 1.8e-142 ymfK S Protein of unknown function (DUF3388)
HPPHLOHB_01795 1.9e-124 ymfM S protein conserved in bacteria
HPPHLOHB_01796 2.5e-101 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPPHLOHB_01797 1.9e-236 cinA 3.5.1.42 S Belongs to the CinA family
HPPHLOHB_01798 8.1e-188 recA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HPPHLOHB_01799 1e-215 pbpX V Beta-lactamase
HPPHLOHB_01800 2.1e-224 rny S Endoribonuclease that initiates mRNA decay
HPPHLOHB_01801 1.9e-152 ymdB S protein conserved in bacteria
HPPHLOHB_01802 1.2e-36 spoVS S Stage V sporulation protein S
HPPHLOHB_01803 2.7e-199 tdh 1.1.1.103 C Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate
HPPHLOHB_01804 6.5e-218 kbl 2.3.1.29, 2.3.1.47 H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide
HPPHLOHB_01805 2.7e-296 miaB 2.8.4.3 J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPPHLOHB_01806 9.2e-69 ymcA 3.6.3.21 S Belongs to the UPF0342 family
HPPHLOHB_01807 2.2e-88 cotE S Spore coat protein
HPPHLOHB_01808 0.0 mutS L that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HPPHLOHB_01809 0.0 mutL L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HPPHLOHB_01810 2.3e-70 S Regulatory protein YrvL
HPPHLOHB_01812 1.2e-97 ymcC S Membrane
HPPHLOHB_01813 4.4e-109 pksA K Transcriptional regulator
HPPHLOHB_01814 2.5e-129 pksB 3.1.2.6 S Polyketide biosynthesis
HPPHLOHB_01815 2.6e-163 fabD 2.3.1.39 I malonyl CoA-acyl carrier protein transacylase
HPPHLOHB_01817 2.4e-186 pksD Q Acyl transferase domain
HPPHLOHB_01818 0.0 fabD 1.13.12.16, 2.3.1.39 I malonyl CoA-acyl carrier protein transacylase
HPPHLOHB_01819 1.4e-37 acpK IQ Phosphopantetheine attachment site
HPPHLOHB_01820 2.7e-238 pksF 2.3.1.179, 2.3.1.41 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
HPPHLOHB_01821 1.3e-245 pksG 2.3.3.10 I synthase
HPPHLOHB_01822 2.6e-143 pksH 4.2.1.18 I enoyl-CoA hydratase
HPPHLOHB_01823 2.7e-137 pksI I Belongs to the enoyl-CoA hydratase isomerase family
HPPHLOHB_01824 0.0 rhiB IQ polyketide synthase
HPPHLOHB_01825 0.0 pfaA Q Polyketide synthase of type I
HPPHLOHB_01826 0.0 pfaA 4.1.1.35 GT4 IQ polyketide synthase
HPPHLOHB_01827 0.0 dhbF IQ polyketide synthase
HPPHLOHB_01828 0.0 pks13 HQ Beta-ketoacyl synthase
HPPHLOHB_01829 2.5e-233 cypA C Cytochrome P450
HPPHLOHB_01830 1.2e-61 ymzB
HPPHLOHB_01831 6.6e-164 ymaE S Metallo-beta-lactamase superfamily
HPPHLOHB_01832 4.6e-252 aprX O Belongs to the peptidase S8 family
HPPHLOHB_01833 2.1e-126 ymaC S Replication protein
HPPHLOHB_01834 5.4e-80 ymaD O redox protein, regulator of disulfide bond formation
HPPHLOHB_01835 4.7e-55 ebrB P COG2076 Membrane transporters of cations and cationic drugs
HPPHLOHB_01836 4.9e-51 ebrA P Small Multidrug Resistance protein
HPPHLOHB_01838 2.1e-46 ymaF S YmaF family
HPPHLOHB_01839 9.3e-175 miaA 2.5.1.75 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HPPHLOHB_01840 1.9e-33 hfq J RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs
HPPHLOHB_01841 6.3e-23
HPPHLOHB_01842 4.5e-22 ymzA
HPPHLOHB_01843 1.9e-49 nrdI 1.17.4.1 F Probably involved in ribonucleotide reductase function
HPPHLOHB_01844 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPPHLOHB_01845 4.5e-188 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPPHLOHB_01846 2e-109 ymaB
HPPHLOHB_01847 8e-116 cwlC 3.5.1.28 M n-acetylmuramoyl-L-alanine amidase
HPPHLOHB_01848 1.7e-176 spoVK O stage V sporulation protein K
HPPHLOHB_01849 5.5e-231 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPPHLOHB_01850 3.3e-244 ynbB 4.4.1.1 P COG4100 Cystathionine beta-lyase family protein involved in aluminum resistance
HPPHLOHB_01851 1.1e-68 glnR K transcriptional
HPPHLOHB_01852 7e-261 glnA 6.3.1.2 E glutamine synthetase
HPPHLOHB_01853 5e-10
HPPHLOHB_01854 2.5e-32
HPPHLOHB_01855 5.8e-39
HPPHLOHB_01856 6.8e-80 G regulation of fungal-type cell wall biogenesis
HPPHLOHB_01857 4.9e-145 ynaC
HPPHLOHB_01858 2e-99 ynaD J Acetyltransferase (GNAT) domain
HPPHLOHB_01859 1.9e-123 ynaE S Domain of unknown function (DUF3885)
HPPHLOHB_01860 6.4e-60 ynaF
HPPHLOHB_01863 1.1e-83 XK27_05370 5.3.1.24 E phosphoribosylanthranilate isomerase activity
HPPHLOHB_01864 2.7e-255 xynT G MFS/sugar transport protein
HPPHLOHB_01865 0.0 xynB 3.2.1.37 GH43 G Belongs to the glycosyl hydrolase 43 family
HPPHLOHB_01866 1e-215 xylR GK ROK family
HPPHLOHB_01867 4e-264 xylA 5.3.1.5 G Belongs to the xylose isomerase family
HPPHLOHB_01868 6e-293 xylB 2.7.1.12, 2.7.1.17, 2.7.1.5 G xylulose kinase
HPPHLOHB_01869 1.4e-113 yokF 3.1.31.1 L RNA catabolic process
HPPHLOHB_01870 3.5e-247 iolT EGP Major facilitator Superfamily
HPPHLOHB_01871 2.7e-219 alr 5.1.1.1 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPPHLOHB_01872 6.3e-84 yncE S Protein of unknown function (DUF2691)
HPPHLOHB_01873 4.9e-78 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F Deoxyuridine 5'-triphosphate
HPPHLOHB_01874 5.2e-15
HPPHLOHB_01877 1.2e-165 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HPPHLOHB_01879 1.3e-134 S Domain of unknown function, YrpD
HPPHLOHB_01882 7.9e-25 tatA U protein secretion
HPPHLOHB_01883 1.8e-71
HPPHLOHB_01884 5.2e-80 yndB S Activator of Hsp90 ATPase homolog 1-like protein
HPPHLOHB_01887 5.7e-286 gerAA EG Spore germination protein
HPPHLOHB_01888 4.5e-197 gerAB U Spore germination
HPPHLOHB_01889 4.2e-220 gerLC S Spore germination protein
HPPHLOHB_01890 7.7e-154 yndG S DoxX-like family
HPPHLOHB_01891 2.6e-117 yndH S Domain of unknown function (DUF4166)
HPPHLOHB_01892 0.0 yndJ S YndJ-like protein
HPPHLOHB_01894 8.6e-139 yndL S Replication protein
HPPHLOHB_01895 5.8e-74 yndM S Protein of unknown function (DUF2512)
HPPHLOHB_01896 2e-79 fosB 2.5.1.18 H Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor
HPPHLOHB_01898 2.6e-109 lexA 3.4.21.88 K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPPHLOHB_01899 3.4e-49 yneA D Inhibits cell division during the SOS response. Affects a later stage of the cell division protein assembly, after the assembly of the Z ring, by probably suppressing recruitment of FtsL and or DivIC to the division machinery
HPPHLOHB_01900 9.2e-113 yneB L resolvase
HPPHLOHB_01901 1.3e-32 ynzC S UPF0291 protein
HPPHLOHB_01902 0.0 tkt 2.2.1.1 G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPPHLOHB_01903 2.2e-81 yneE S Sporulation inhibitor of replication protein sirA
HPPHLOHB_01904 1.8e-28 yneF S UPF0154 protein
HPPHLOHB_01905 7.5e-14 ynzD S Spo0E like sporulation regulatory protein
HPPHLOHB_01906 7.1e-127 ccdA O cytochrome c biogenesis protein
HPPHLOHB_01907 7.2e-59 cheB 3.1.1.61, 3.5.1.44 T cheY-homologous receiver domain
HPPHLOHB_01908 5.1e-76 yneJ O COG4846 Membrane protein involved in cytochrome C biogenesis
HPPHLOHB_01909 4.2e-74 yneK S Protein of unknown function (DUF2621)
HPPHLOHB_01910 4.1e-65 hspX O Spore coat protein
HPPHLOHB_01911 3.9e-19 sspP S Belongs to the SspP family
HPPHLOHB_01912 2.2e-14 sspO S Belongs to the SspO family
HPPHLOHB_01913 0.0 acnA 4.2.1.3 C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HPPHLOHB_01914 4.1e-92 yneN CO alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPPHLOHB_01916 3.1e-08 sspN S Small acid-soluble spore protein N family
HPPHLOHB_01917 3.9e-35 tlp S Belongs to the Tlp family
HPPHLOHB_01918 1.2e-73 yneP S Thioesterase-like superfamily
HPPHLOHB_01919 1.3e-53 yneQ
HPPHLOHB_01920 4.1e-49 yneR S Belongs to the HesB IscA family
HPPHLOHB_01921 5e-94 plsY 2.3.1.15, 3.5.1.104 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
HPPHLOHB_01922 6.6e-69 yccU S CoA-binding protein
HPPHLOHB_01923 0.0 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HPPHLOHB_01924 0.0 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HPPHLOHB_01925 2.3e-12
HPPHLOHB_01926 1.3e-57 ynfC
HPPHLOHB_01927 8.2e-252 agcS E Sodium alanine symporter
HPPHLOHB_01928 2.4e-297 bglC5 3.2.1.4 GH5,GH9 G PFAM glycoside hydrolase family 5
HPPHLOHB_01930 3.7e-251 xynC 3.2.1.136 GH5 M Belongs to the glycosyl hydrolase 30 family
HPPHLOHB_01931 4.4e-299 xynD3 3.2.1.55 CBM6,GH43 G Belongs to the glycosyl hydrolase 43 family
HPPHLOHB_01932 2.4e-80 yngA S membrane
HPPHLOHB_01933 4.1e-164 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
HPPHLOHB_01934 5.5e-104 yngC S membrane-associated protein
HPPHLOHB_01935 1.9e-233 nrnB S phosphohydrolase (DHH superfamily)
HPPHLOHB_01936 6.3e-290 yngE 2.1.3.15, 6.4.1.3 I COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
HPPHLOHB_01937 2.2e-137 yngF 4.2.1.17 I Belongs to the enoyl-CoA hydratase isomerase family
HPPHLOHB_01938 8e-168 mvaB 4.1.3.4, 6.4.1.4 E Hydroxymethylglutaryl-CoA lyase
HPPHLOHB_01939 6e-32 pycB 2.3.1.12, 6.4.1.1 I Biotin carboxyl carrier protein
HPPHLOHB_01940 3e-251 yngH 6.3.4.14, 6.4.1.2, 6.4.1.3, 6.4.1.4 I Biotin carboxylase
HPPHLOHB_01941 0.0 yngI IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
HPPHLOHB_01942 4.4e-211 yngJ 1.3.8.1, 1.3.99.12 I acyl-CoA dehydrogenase
HPPHLOHB_01943 1.8e-31 S Family of unknown function (DUF5367)
HPPHLOHB_01944 1.3e-306 yngK T Glycosyl hydrolase-like 10
HPPHLOHB_01945 2.8e-64 yngL S Protein of unknown function (DUF1360)
HPPHLOHB_01946 0.0 6.3.2.14 Q amino acid activation for nonribosomal peptide biosynthetic process
HPPHLOHB_01947 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HPPHLOHB_01948 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HPPHLOHB_01949 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HPPHLOHB_01950 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HPPHLOHB_01951 4.3e-275 dacC 3.4.16.4 M D-alanyl-D-alanine carboxypeptidase
HPPHLOHB_01952 6e-193 yoxA 5.1.3.3 G Aldose 1-epimerase
HPPHLOHB_01953 2.3e-246 yoeA V MATE efflux family protein
HPPHLOHB_01954 1.1e-98 yoeB S IseA DL-endopeptidase inhibitor
HPPHLOHB_01956 2.2e-96 L Integrase
HPPHLOHB_01957 3e-34 yoeD G Helix-turn-helix domain
HPPHLOHB_01958 0.0 ggt 2.3.2.2, 3.4.19.13 E gamma-glutamyltransferase
HPPHLOHB_01959 2.5e-158 gltR1 K Transcriptional regulator
HPPHLOHB_01960 5e-187 yogA C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases
HPPHLOHB_01961 2.7e-293 gltD 1.4.1.13, 1.4.1.14 E COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases
HPPHLOHB_01962 0.0 gltB 1.4.1.13, 1.4.1.14, 1.4.7.1 E glutamate synthase
HPPHLOHB_01963 7.8e-155 gltC K Transcriptional regulator
HPPHLOHB_01964 4.1e-206 proB 2.7.2.11 E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPPHLOHB_01965 2.5e-144 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPPHLOHB_01966 1.9e-59 rtp K Plays a role in DNA replication and termination (fork arrest mechanism). Two dimers of rtp bind to the two inverted repeat regions (IRI and IRII) present in the termination site. The binding of each dimer is centered on an 8 bp direct repeat
HPPHLOHB_01967 2.2e-123 fabG 1.1.1.100 S Belongs to the short-chain dehydrogenases reductases (SDR) family
HPPHLOHB_01968 3e-42 yoxC S Bacterial protein of unknown function (DUF948)
HPPHLOHB_01969 3.1e-144 yoxB
HPPHLOHB_01970 7.5e-97 yoaA 2.3.1.128 J COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
HPPHLOHB_01971 6.2e-235 yoaB EGP Major facilitator Superfamily
HPPHLOHB_01972 1e-284 yoaC 2.7.1.12, 2.7.1.17, 2.7.1.189, 2.7.1.5 G FGGY family of carbohydrate kinases, C-terminal domain
HPPHLOHB_01973 1.7e-190 yoaD 1.1.1.399, 1.1.1.95 EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPPHLOHB_01974 0.0 yoaE C belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HPPHLOHB_01975 1.9e-33 yoaF
HPPHLOHB_01976 2.2e-08 ywlA S Uncharacterised protein family (UPF0715)
HPPHLOHB_01977 7e-14
HPPHLOHB_01978 1.5e-38 S Protein of unknown function (DUF4025)
HPPHLOHB_01979 1.7e-187 mcpU NT methyl-accepting chemotaxis protein
HPPHLOHB_01980 8.7e-281 hpaB 1.14.14.9 Q COG2368 Aromatic ring hydroxylase
HPPHLOHB_01981 3.8e-133 yoaJ G Endoglucanase C-terminal domain subunit and related proteins
HPPHLOHB_01982 2.3e-111 yoaK S Membrane
HPPHLOHB_01983 2.3e-198 pelB 4.2.2.10, 4.2.2.2 G Amb_all
HPPHLOHB_01984 1.1e-132 yoqW S Belongs to the SOS response-associated peptidase family
HPPHLOHB_01986 3.8e-234 oxdC 4.1.1.2 G Oxalate decarboxylase
HPPHLOHB_01988 1.5e-146 yoaP 3.1.3.18 K YoaP-like
HPPHLOHB_01989 1.2e-66 yoaQ S Evidence 4 Homologs of previously reported genes of
HPPHLOHB_01990 4.1e-89
HPPHLOHB_01991 2.4e-172 yoaR V vancomycin resistance protein
HPPHLOHB_01992 4.3e-75 yoaS S Protein of unknown function (DUF2975)
HPPHLOHB_01993 4.2e-37 yozG K Transcriptional regulator
HPPHLOHB_01994 1.1e-149 yoaT S Protein of unknown function (DUF817)
HPPHLOHB_01995 8.6e-159 yoaU K LysR substrate binding domain
HPPHLOHB_01996 6e-160 yijE EG EamA-like transporter family
HPPHLOHB_01997 3.7e-78 yoaW
HPPHLOHB_01998 1.1e-118 yoaZ 1.11.1.6, 3.5.1.124 S DJ-1/PfpI family
HPPHLOHB_01999 2.3e-170 bla 3.5.2.6 V beta-lactamase
HPPHLOHB_02003 0.0 pps 2.7.9.2 GT phosphoenolpyruvate synthase
HPPHLOHB_02004 1.8e-121 xlnB 3.2.1.8 G Glycosyl hydrolases family 11
HPPHLOHB_02005 1.4e-37 S TM2 domain
HPPHLOHB_02006 5.7e-58 K Helix-turn-helix
HPPHLOHB_02008 1.6e-69 yoaQ S Evidence 4 Homologs of previously reported genes of
HPPHLOHB_02009 6.6e-127 yoqW S Belongs to the SOS response-associated peptidase family
HPPHLOHB_02010 1.8e-178 yobF
HPPHLOHB_02015 1.7e-207 S aspartate phosphatase
HPPHLOHB_02017 1.2e-123 dinB2 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HPPHLOHB_02018 1.4e-59 dinB2 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HPPHLOHB_02019 2.6e-38 S YolD-like protein
HPPHLOHB_02020 1.2e-49
HPPHLOHB_02021 0.0 K Psort location Cytoplasmic, score
HPPHLOHB_02022 2.7e-157 yobJ
HPPHLOHB_02023 3e-86 S SMI1-KNR4 cell-wall
HPPHLOHB_02024 0.0 L A nuclease of the HNH/ENDO VII superfamily with conserved LHH
HPPHLOHB_02025 7.9e-105 yokH G SMI1 / KNR4 family
HPPHLOHB_02026 9.5e-280 iaaM 1.4.3.4 E COG1231 Monoamine oxidase
HPPHLOHB_02027 0.0 yobO M Pectate lyase superfamily protein
HPPHLOHB_02028 9.9e-55 csaA 6.1.1.10, 6.1.1.20, 6.1.1.6 J tRNA-binding protein
HPPHLOHB_02029 1e-136 yobQ K helix_turn_helix, arabinose operon control protein
HPPHLOHB_02030 2.5e-143 yobR 2.3.1.1 J FR47-like protein
HPPHLOHB_02031 3e-99 yobS K Transcriptional regulator
HPPHLOHB_02032 4.2e-132 yobT S COG0491 Zn-dependent hydrolases, including glyoxylases
HPPHLOHB_02033 1.5e-88 yobU K Bacterial transcription activator, effector binding domain
HPPHLOHB_02034 9e-178 yobV K WYL domain
HPPHLOHB_02035 2.5e-95 yobW
HPPHLOHB_02036 1e-51 czrA K transcriptional
HPPHLOHB_02037 4.4e-118 pvaA M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)
HPPHLOHB_02038 1.5e-92 yozB S membrane
HPPHLOHB_02039 2.2e-145
HPPHLOHB_02040 1.9e-94 yocC
HPPHLOHB_02041 6.9e-189 yocD 3.4.17.13 V peptidase S66
HPPHLOHB_02042 4.1e-203 des 1.14.19.23, 1.14.19.45 I fatty acid desaturase
HPPHLOHB_02043 3.2e-198 desK 2.7.13.3 T Histidine kinase
HPPHLOHB_02044 1e-105 desR T COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HPPHLOHB_02045 7.1e-113 yocH CBM50 M COG1388 FOG LysM repeat
HPPHLOHB_02046 0.0 recQ 3.6.4.12 L DNA helicase
HPPHLOHB_02047 7.9e-114 azoR I Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HPPHLOHB_02048 3.3e-83 dksA T general stress protein
HPPHLOHB_02049 6.4e-54 yocL
HPPHLOHB_02050 6.6e-34
HPPHLOHB_02051 1.3e-87 yocM O Belongs to the small heat shock protein (HSP20) family
HPPHLOHB_02052 1.1e-40 yozN
HPPHLOHB_02053 1.9e-36 yocN
HPPHLOHB_02054 4.2e-56 yozO S Bacterial PH domain
HPPHLOHB_02055 2.7e-31 yozC
HPPHLOHB_02056 4e-289 dhaS 1.2.1.3, 1.2.1.39 C Belongs to the aldehyde dehydrogenase family
HPPHLOHB_02057 0.0 sqhC 4.2.1.137, 5.4.99.7 I COG1657 Squalene cyclase
HPPHLOHB_02058 5.4e-166 sodA 1.15.1.1 P Superoxide dismutase
HPPHLOHB_02059 3.4e-231 yocR S Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
HPPHLOHB_02060 5.1e-168 yocS S -transporter
HPPHLOHB_02061 1.8e-194 sucB 2.3.1.61 C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)
HPPHLOHB_02062 0.0 sucA 1.2.4.2, 4.1.1.71 C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)
HPPHLOHB_02063 0.0 yojO P Von Willebrand factor
HPPHLOHB_02064 1.1e-161 yojN S ATPase family associated with various cellular activities (AAA)
HPPHLOHB_02065 1e-110 sodC 1.15.1.1 P Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HPPHLOHB_02066 1.6e-198 sle1 3.5.1.28 CBM50 M COG1388 FOG LysM repeat
HPPHLOHB_02067 1.8e-231 yojK CG UDP-glucoronosyl and UDP-glucosyl transferase
HPPHLOHB_02068 1.2e-109 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HPPHLOHB_02070 4.2e-245 norM V Multidrug efflux pump
HPPHLOHB_02071 8.4e-151 T COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
HPPHLOHB_02072 2.1e-125 yojG S deacetylase
HPPHLOHB_02073 2.2e-60 yojF S Protein of unknown function (DUF1806)
HPPHLOHB_02074 1.5e-43
HPPHLOHB_02075 3.5e-163 rarD S -transporter
HPPHLOHB_02076 2.6e-61 yozR S COG0071 Molecular chaperone (small heat shock protein)
HPPHLOHB_02077 3.4e-09
HPPHLOHB_02078 8.2e-209 gntP EG COG2610 H gluconate symporter and related permeases
HPPHLOHB_02079 3.8e-66 yodA S tautomerase
HPPHLOHB_02080 1.7e-57 yodB K transcriptional
HPPHLOHB_02081 4.8e-108 yodC C nitroreductase
HPPHLOHB_02082 3.8e-113 mhqD S Carboxylesterase
HPPHLOHB_02083 5.8e-174 yodE E COG0346 Lactoylglutathione lyase and related lyases
HPPHLOHB_02084 6.2e-28 S Protein of unknown function (DUF3311)
HPPHLOHB_02085 4.2e-270 yodF E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPPHLOHB_02086 1.9e-253 ctpA 3.4.21.102 M Belongs to the peptidase S41A family
HPPHLOHB_02087 1.7e-128 yodH Q Methyltransferase
HPPHLOHB_02088 5.2e-24 yodI
HPPHLOHB_02089 2.5e-139 vanY 3.4.17.14 M D-alanyl-D-alanine carboxypeptidase
HPPHLOHB_02090 3.2e-127 deoD 2.4.2.1, 2.4.2.28 F Purine nucleoside phosphorylase
HPPHLOHB_02091 5.3e-09
HPPHLOHB_02092 3.6e-54 yodL S YodL-like
HPPHLOHB_02093 5.4e-107 yodM 3.6.1.27 I Acid phosphatase homologues
HPPHLOHB_02094 2.8e-24 yozD S YozD-like protein
HPPHLOHB_02096 1.4e-124 yodN
HPPHLOHB_02097 1.4e-36 yozE S Belongs to the UPF0346 family
HPPHLOHB_02098 2.9e-47 yokU S YokU-like protein, putative antitoxin
HPPHLOHB_02099 1.4e-278 kamA 5.4.3.2 E lysine 2,3-aminomutase
HPPHLOHB_02100 2.5e-155 yodP 2.3.1.264 K Acetyltransferase (GNAT) family
HPPHLOHB_02101 1.4e-258 yodQ 3.5.1.16 E Acetylornithine deacetylase
HPPHLOHB_02102 1.6e-117 scoB 2.8.3.5, 2.8.3.8, 2.8.3.9 I COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit
HPPHLOHB_02103 8.1e-10 yodS 2.8.3.8, 2.8.3.9 I COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HPPHLOHB_02104 1.6e-249 yodT H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPPHLOHB_02107 2.9e-145 yiiD K acetyltransferase
HPPHLOHB_02108 1e-256 cgeD M maturation of the outermost layer of the spore
HPPHLOHB_02109 3.5e-38 cgeC
HPPHLOHB_02110 1.2e-65 cgeA
HPPHLOHB_02111 3.3e-188 cgeB S Spore maturation protein
HPPHLOHB_02112 3.6e-213 phy 3.1.3.8 I Myo-inositol-hexaphosphate 3-phosphohydrolase
HPPHLOHB_02113 2.5e-63 4.2.1.115 GM Polysaccharide biosynthesis protein
HPPHLOHB_02115 3.6e-108 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
HPPHLOHB_02116 1.4e-10 K Cro/C1-type HTH DNA-binding domain
HPPHLOHB_02124 1.9e-168 S Calcineurin-like phosphoesterase
HPPHLOHB_02125 2.5e-30 sspB S spore protein
HPPHLOHB_02130 8.9e-83 yosT L Bacterial transcription activator, effector binding domain
HPPHLOHB_02131 2.4e-77 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F Deoxyuridine 5'-triphosphate
HPPHLOHB_02132 6.1e-38 O Glutaredoxin
HPPHLOHB_02133 2.8e-66 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPPHLOHB_02134 3.3e-97 L HNH endonuclease
HPPHLOHB_02135 1e-107 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPPHLOHB_02136 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPPHLOHB_02137 2.3e-117 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPPHLOHB_02138 5.1e-66 nrdI 1.17.4.1 F Probably involved in ribonucleotide reductase function
HPPHLOHB_02155 1.5e-255 dcm 2.1.1.37 L DNA (cytosine-5-)-methyltransferase activity
HPPHLOHB_02157 1.2e-96 yorS 3.1.3.5 S 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
HPPHLOHB_02158 5.9e-88 tmk 2.1.1.45, 2.7.4.9 F dTDP biosynthetic process
HPPHLOHB_02163 9.9e-115 DR0488 S protein conserved in bacteria
HPPHLOHB_02164 0.0 2.7.7.7 L DNA polymerase
HPPHLOHB_02165 0.0 recJ L Single-stranded-DNA-specific exonuclease RecJ
HPPHLOHB_02166 1.2e-224 L DNA primase activity
HPPHLOHB_02167 3.6e-285 3.6.4.12 J DnaB-like helicase C terminal domain
HPPHLOHB_02168 1.4e-86
HPPHLOHB_02169 7.6e-180 L AAA domain
HPPHLOHB_02170 1.3e-170
HPPHLOHB_02175 0.0 M Parallel beta-helix repeats
HPPHLOHB_02176 7.7e-149 S Pfam:DUF867
HPPHLOHB_02179 1e-130 yoqW S Belongs to the SOS response-associated peptidase family
HPPHLOHB_02180 2.4e-155 ligB 6.5.1.1, 6.5.1.6, 6.5.1.7 L ATP-dependent DNA ligase
HPPHLOHB_02181 2.3e-77
HPPHLOHB_02188 1e-44
HPPHLOHB_02190 1.5e-97 S Protein of unknown function (DUF1273)
HPPHLOHB_02192 3e-78 yoqH M LysM domain
HPPHLOHB_02195 8.8e-12 S Protein of unknown function (DUF2815)
HPPHLOHB_02196 6.2e-137 kilA S Phage regulatory protein Rha (Phage_pRha)
HPPHLOHB_02207 1.1e-33 K Transcriptional regulator
HPPHLOHB_02208 2.1e-177
HPPHLOHB_02209 6e-263 S DNA-sulfur modification-associated
HPPHLOHB_02210 6.8e-198 L Belongs to the 'phage' integrase family
HPPHLOHB_02215 6.6e-106
HPPHLOHB_02217 1.2e-86
HPPHLOHB_02218 1.1e-96 S Super-infection exclusion protein B
HPPHLOHB_02223 1.1e-07 ywlA S Uncharacterised protein family (UPF0715)
HPPHLOHB_02224 3.8e-259
HPPHLOHB_02225 4.6e-35 K Cro/C1-type HTH DNA-binding domain
HPPHLOHB_02226 1.4e-256
HPPHLOHB_02228 5.9e-238
HPPHLOHB_02230 4e-17
HPPHLOHB_02231 5.7e-55 bldD K domain, Protein
HPPHLOHB_02234 0.0
HPPHLOHB_02235 1.8e-41 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
HPPHLOHB_02237 2.6e-230
HPPHLOHB_02240 1.8e-175
HPPHLOHB_02241 0.0 gp17a S Terminase-like family
HPPHLOHB_02242 6.3e-282
HPPHLOHB_02243 2.1e-266
HPPHLOHB_02244 1.6e-94
HPPHLOHB_02245 5.7e-186
HPPHLOHB_02246 5.1e-81
HPPHLOHB_02247 1.1e-68
HPPHLOHB_02249 1.4e-121
HPPHLOHB_02250 2.6e-91
HPPHLOHB_02251 8.1e-131
HPPHLOHB_02252 1.6e-90
HPPHLOHB_02255 1e-57
HPPHLOHB_02256 1.1e-172
HPPHLOHB_02257 8.1e-07
HPPHLOHB_02258 2.5e-10 xkdX
HPPHLOHB_02259 2.5e-86
HPPHLOHB_02260 6.3e-70
HPPHLOHB_02261 2.1e-193 xerH A Belongs to the 'phage' integrase family
HPPHLOHB_02266 9.3e-116
HPPHLOHB_02267 0.0 XK26_06135 M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)
HPPHLOHB_02268 6.2e-145 S Phage tail protein
HPPHLOHB_02269 0.0 S Pfam Transposase IS66
HPPHLOHB_02270 6.4e-115
HPPHLOHB_02271 0.0 G Exopolysaccharide biosynthesis protein
HPPHLOHB_02272 6.5e-164
HPPHLOHB_02274 1.6e-186 3.5.1.28 M Ami_2
HPPHLOHB_02275 4.4e-32 bhlA S BhlA holin family
HPPHLOHB_02276 5.5e-40 S SPP1 phage holin
HPPHLOHB_02277 3.4e-74 O protein disulfide oxidoreductase activity
HPPHLOHB_02278 4.1e-242 M COG0463 Glycosyltransferases involved in cell wall biogenesis
HPPHLOHB_02279 1.2e-70 CO cell redox homeostasis
HPPHLOHB_02280 0.0 V Peptidase C39 family
HPPHLOHB_02283 1.9e-239 S impB/mucB/samB family C-terminal domain
HPPHLOHB_02284 5.8e-55 S YolD-like protein
HPPHLOHB_02285 1.3e-37
HPPHLOHB_02287 6.8e-09 S Domain of unknown function (DUF4879)
HPPHLOHB_02289 2.8e-99 J Acetyltransferase (GNAT) domain
HPPHLOHB_02290 3.2e-109 yokK S SMI1 / KNR4 family
HPPHLOHB_02291 1.9e-94 yokJ S SMI1 / KNR4 family (SUKH-1)
HPPHLOHB_02292 1.2e-302 UW nuclease activity
HPPHLOHB_02293 6.7e-92 yokH G SMI1 / KNR4 family
HPPHLOHB_02294 4.1e-203
HPPHLOHB_02295 3.3e-113 yokF 3.1.31.1 L RNA catabolic process
HPPHLOHB_02296 1.1e-83 S Bacterial PH domain
HPPHLOHB_02297 8.4e-156 aacC 2.3.1.81 V aminoglycoside
HPPHLOHB_02300 8.9e-95
HPPHLOHB_02301 1.6e-107
HPPHLOHB_02302 2.7e-307 yokA L Recombinase
HPPHLOHB_02303 1.4e-96 4.2.1.115 GM Polysaccharide biosynthesis protein
HPPHLOHB_02304 1.4e-80 msrB 1.8.4.11, 1.8.4.12 O peptide methionine sulfoxide reductase
HPPHLOHB_02305 7e-103 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPPHLOHB_02306 1.6e-70 ypoP K transcriptional
HPPHLOHB_02307 2.6e-223 mepA V MATE efflux family protein
HPPHLOHB_02308 5.5e-29 ypmT S Uncharacterized ympT
HPPHLOHB_02309 5e-99 ypmS S protein conserved in bacteria
HPPHLOHB_02310 1.3e-137 ypmR E GDSL-like Lipase/Acylhydrolase
HPPHLOHB_02311 3.2e-109 ypmQ S protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems
HPPHLOHB_02312 3.1e-40 ypmP S Protein of unknown function (DUF2535)
HPPHLOHB_02313 4.4e-244 ilvA 4.3.1.19 E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HPPHLOHB_02314 1.6e-185 pspF K Transcriptional regulator
HPPHLOHB_02315 4.2e-110 hlyIII S protein, Hemolysin III
HPPHLOHB_02316 7.4e-112 ypkP 2.3.1.51 I Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family
HPPHLOHB_02317 7.9e-96 folA 1.1.1.262, 1.5.1.3 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HPPHLOHB_02318 4.3e-157 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HPPHLOHB_02319 3.3e-92 pgpA 3.1.3.27 I COG1267 Phosphatidylglycerophosphatase A and related proteins
HPPHLOHB_02320 7.8e-114 ypjP S YpjP-like protein
HPPHLOHB_02321 1.3e-145 ypiP 2.1.1.242 AJ Putative SAM-dependent methyltransferase
HPPHLOHB_02322 1.7e-75 yphP S Belongs to the UPF0403 family
HPPHLOHB_02323 0.0 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
HPPHLOHB_02324 1.8e-156 ypgR C COG0694 Thioredoxin-like proteins and domains
HPPHLOHB_02325 3.1e-110 ypgQ S phosphohydrolase
HPPHLOHB_02326 2.3e-89 btuE 1.11.1.9 O Belongs to the glutathione peroxidase family
HPPHLOHB_02327 7.3e-177 metAA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HPPHLOHB_02328 2e-216 ugtP 2.4.1.315 GT28 M Processive glucosyltransferase involved in the biosynthesis of both the bilayer- and non-bilayer-forming membrane glucolipids. Is able to successively transfer up to three glucosyl residues to diacylglycerol (DAG), thereby catalyzing the formation of beta-monoglucosyl-DAG (3-O-(beta-D-glucopyranosyl)-1,2-diacyl- sn-glycerol), beta-diglucosyl-DAG (3-O-(beta-D-glucopyranosyl- beta-(1- 6)-D-glucopyranosyl)-1,2-diacyl-sn-glycerol) and beta- triglucosyl-DAG (3-O-(beta-D-glucopyranosyl-beta-(1- 6)-D- glucopyranosyl-beta-(1- 6)-D-glucopyranosyl)-1,2-diacyl-sn- glycerol). Beta-diglucosyl-DAG is the predominant glycolipid found in Bacillales and is also used as a membrane anchor for lipoteichoic acid (LTA)
HPPHLOHB_02329 7.9e-31 cspD K Cold-shock protein
HPPHLOHB_02330 3.8e-16 degR
HPPHLOHB_02331 8.1e-31 S Protein of unknown function (DUF2564)
HPPHLOHB_02332 2.6e-27 ypeQ S Zinc-finger
HPPHLOHB_02333 8.9e-127 ypeP 3.1.26.4 L COG0328 Ribonuclease HI
HPPHLOHB_02334 5.4e-107 ypdP S Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HPPHLOHB_02335 8.5e-69 rnhA 3.1.26.4 L Ribonuclease
HPPHLOHB_02337 1.5e-166 polA 2.7.7.7 L 5'3' exonuclease
HPPHLOHB_02338 2e-07
HPPHLOHB_02339 1e-38 ypbS S Protein of unknown function (DUF2533)
HPPHLOHB_02340 0.0 ypbR S Dynamin family
HPPHLOHB_02341 5.1e-87 ypbQ S protein conserved in bacteria
HPPHLOHB_02342 4.4e-208 bcsA Q Naringenin-chalcone synthase
HPPHLOHB_02343 1.6e-228 pbuX F xanthine
HPPHLOHB_02344 8.8e-99 xpt 2.4.2.22, 2.4.2.7 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
HPPHLOHB_02345 4.2e-294 ypwA 3.4.17.19 E Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HPPHLOHB_02346 5e-171 kdgT P The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system
HPPHLOHB_02347 7e-104 eda 2.7.1.45, 4.1.2.14, 4.1.3.42 G 2-dehydro-3-deoxy-phosphogluconate aldolase
HPPHLOHB_02348 2.9e-187 kdgK 2.7.1.45 G COG0524 Sugar kinases, ribokinase family
HPPHLOHB_02349 3.9e-187 ptxS K transcriptional
HPPHLOHB_02350 1.7e-159 kduI 5.3.1.17 G Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HPPHLOHB_02351 7.1e-133 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HPPHLOHB_02352 0.0 ypvA 3.6.4.12 KL COG1199 Rad3-related DNA helicases
HPPHLOHB_02354 5.4e-225 rlmL 2.1.1.173, 2.1.1.264 L Belongs to the methyltransferase superfamily
HPPHLOHB_02355 2.8e-45 gpsB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
HPPHLOHB_02356 3.3e-92 ypsA S Belongs to the UPF0398 family
HPPHLOHB_02357 1.3e-237 yprB L RNase_H superfamily
HPPHLOHB_02358 0.0 yprA L COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster
HPPHLOHB_02359 1.9e-81 ypqE 2.7.1.199 G COG2190 Phosphotransferase system IIA components
HPPHLOHB_02360 8.6e-72 hspX O Belongs to the small heat shock protein (HSP20) family
HPPHLOHB_02361 1.2e-48 yppG S YppG-like protein
HPPHLOHB_02363 2e-11 yppE S Bacterial domain of unknown function (DUF1798)
HPPHLOHB_02366 2.6e-188 yppC S Protein of unknown function (DUF2515)
HPPHLOHB_02367 1.2e-114 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
HPPHLOHB_02368 0.0 ponA 2.4.1.129, 2.7.7.7, 3.4.16.4 GT51 M penicillin-binding protein
HPPHLOHB_02369 4.7e-93 ypoC
HPPHLOHB_02370 2.2e-122 nth 4.2.99.18 L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPPHLOHB_02371 5.7e-129 dnaD L DNA replication protein DnaD
HPPHLOHB_02372 5.8e-252 asnS 6.1.1.22 J asparaginyl-tRNA
HPPHLOHB_02373 1.5e-222 aspB 2.6.1.1, 2.6.1.14 E Aminotransferase
HPPHLOHB_02374 3.4e-80 ypmB S protein conserved in bacteria
HPPHLOHB_02375 6.7e-23 ypmA S Protein of unknown function (DUF4264)
HPPHLOHB_02376 0.0 dinG 2.7.7.7, 3.6.4.12 L helicase involved in DNA repair and perhaps also replication
HPPHLOHB_02377 3.5e-64 panD 4.1.1.11 H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HPPHLOHB_02378 1.2e-157 panC 2.7.4.25, 6.3.2.1 H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HPPHLOHB_02379 1.4e-150 panB 2.1.2.11 H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
HPPHLOHB_02380 8.7e-184 birA 6.3.4.15 K Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
HPPHLOHB_02381 4.4e-222 cca 2.7.7.19, 2.7.7.72 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HPPHLOHB_02382 3.7e-210 bshA GT4 M N-acetyl-alpha-D-glucosaminyl L-malate synthase
HPPHLOHB_02383 6.9e-130 bshB1 S proteins, LmbE homologs
HPPHLOHB_02384 6.5e-72 mgsA 2.7.1.24, 4.2.3.3 G methylglyoxal synthase
HPPHLOHB_02385 6.3e-148 dapB 1.17.1.8 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
HPPHLOHB_02386 3.1e-56 ypjD 2.5.1.19 S Nucleotide pyrophosphohydrolase
HPPHLOHB_02387 8.1e-157 ypjC S Uncharacterized protein conserved in bacteria (DUF2179)
HPPHLOHB_02388 6.1e-143 ypjB S sporulation protein
HPPHLOHB_02389 4.4e-98 ypjA S membrane
HPPHLOHB_02390 1.5e-146 qcrC C Menaquinol-cytochrome c reductase cytochrome b c subunit
HPPHLOHB_02391 5.2e-127 petB C COG1290 Cytochrome b subunit of the bc complex
HPPHLOHB_02392 9.3e-97 qcrA C Menaquinol-cytochrome c reductase
HPPHLOHB_02393 8.5e-78 ypiF S Protein of unknown function (DUF2487)
HPPHLOHB_02394 2.8e-99 ypiB S Belongs to the UPF0302 family
HPPHLOHB_02395 4.1e-234 S COG0457 FOG TPR repeat
HPPHLOHB_02396 8.9e-237 aroA 1.3.1.12, 1.3.1.43, 2.5.1.19 E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
HPPHLOHB_02397 1.2e-208 tyrA 1.3.1.12, 1.3.1.43 E prephenate dehydrogenase
HPPHLOHB_02398 2.9e-204 hisC 2.6.1.9 E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPPHLOHB_02399 5.5e-144 trpA 4.2.1.20 E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
HPPHLOHB_02400 4e-231 trpB 4.2.1.20, 5.3.1.24 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HPPHLOHB_02401 6.5e-119 trpF 4.1.1.48, 4.2.1.160, 4.2.1.20, 5.3.1.24 E Belongs to the TrpF family
HPPHLOHB_02402 4.7e-113 trpC 4.1.1.48, 5.3.1.24 E Belongs to the TrpC family
HPPHLOHB_02403 1.2e-180 trpD 2.4.2.18, 4.1.3.27 E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPPHLOHB_02404 6.6e-295 trpE 4.1.3.27 EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPPHLOHB_02405 1e-63 aroH 2.7.4.25, 5.4.99.5 E Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis
HPPHLOHB_02406 8.1e-207 aroB 2.7.1.71, 4.2.3.4 E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HPPHLOHB_02407 5.5e-217 aroC 4.2.3.5 E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HPPHLOHB_02408 2.9e-142 cheR 2.1.1.80 NT COG1352 Methylase of chemotaxis methyl-accepting proteins
HPPHLOHB_02409 9.1e-80 ndk 2.7.4.6 F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
HPPHLOHB_02410 4.5e-194 hepT 2.5.1.30, 2.5.1.83, 2.5.1.90 H Belongs to the FPP GGPP synthase family
HPPHLOHB_02411 8.6e-133 menG 2.1.1.163, 2.1.1.201 H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)
HPPHLOHB_02412 5.6e-138 hepS 2.5.1.30 H Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1
HPPHLOHB_02413 2.3e-34 mtrB K Required for transcription attenuation control in the Trp operon. This trans-acting factor seems to recognize a 10 bases nucleotide sequence in the Trp leader transcript causing transcription termination. Binds the leader RNA only in presence of L-tryptophan
HPPHLOHB_02414 7.1e-101 folE 3.5.4.16 H GTP cyclohydrolase
HPPHLOHB_02415 4.7e-42 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
HPPHLOHB_02416 3.7e-279 spoIVA S ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HPPHLOHB_02417 5.4e-138 yphF
HPPHLOHB_02418 1.6e-18 yphE S Protein of unknown function (DUF2768)
HPPHLOHB_02419 2.3e-190 gpsA 1.1.1.94 I Glycerol-3-phosphate dehydrogenase
HPPHLOHB_02420 3.9e-248 der 1.1.1.399, 1.1.1.95 S GTPase that plays an essential role in the late steps of ribosome biogenesis
HPPHLOHB_02421 1.6e-28 ypzH
HPPHLOHB_02422 2.5e-161 seaA S YIEGIA protein
HPPHLOHB_02423 1.3e-102 yphA
HPPHLOHB_02424 1e-07 S YpzI-like protein
HPPHLOHB_02425 4.1e-187 fni 1.1.1.88, 5.3.3.2 C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
HPPHLOHB_02426 4.3e-206 rpsA 1.17.7.4 J Ribosomal protein S1
HPPHLOHB_02427 1.9e-113 cmk 1.17.7.4, 2.5.1.19, 2.7.1.26, 2.7.4.25, 2.7.7.2, 6.3.2.1 F Belongs to the cytidylate kinase family. Type 1 subfamily
HPPHLOHB_02428 1.8e-23 S Family of unknown function (DUF5359)
HPPHLOHB_02429 9.2e-113 ypfA M Flagellar protein YcgR
HPPHLOHB_02430 6.5e-254 hemX 2.1.1.107, 4.2.1.75 H sporulation protein
HPPHLOHB_02431 4.7e-155 sleB 3.5.1.28 M Spore cortex-lytic enzyme
HPPHLOHB_02432 1e-119 prsW S Involved in the degradation of specific anti-sigma factors
HPPHLOHB_02433 1.6e-174 ypdA 1.18.1.2, 1.19.1.1, 1.8.1.9 O COG0492 Thioredoxin reductase
HPPHLOHB_02434 2.6e-244 gudB 1.4.1.2, 1.4.1.3 E Belongs to the Glu Leu Phe Val dehydrogenases family
HPPHLOHB_02435 2.4e-104 mecB NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC
HPPHLOHB_02436 1.8e-147 ypbG S Calcineurin-like phosphoesterase superfamily domain
HPPHLOHB_02437 2.8e-81 ypbF S Protein of unknown function (DUF2663)
HPPHLOHB_02438 4.6e-81 ypbE M Lysin motif
HPPHLOHB_02439 2.2e-100 ypbD S metal-dependent membrane protease
HPPHLOHB_02440 3.2e-286 recQ 3.6.4.12 L DNA helicase
HPPHLOHB_02441 3.8e-201 ypbB 5.1.3.1 S protein conserved in bacteria
HPPHLOHB_02442 4.7e-41 fer C Ferredoxin
HPPHLOHB_02443 5.8e-87 fmnP U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HPPHLOHB_02444 1.5e-294 serA 1.1.1.399, 1.1.1.95 E Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPPHLOHB_02445 9e-136 aroD 1.1.1.25, 4.2.1.10 E Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
HPPHLOHB_02446 6.8e-201 rsiX
HPPHLOHB_02447 2.6e-103 sigX K Belongs to the sigma-70 factor family. ECF subfamily
HPPHLOHB_02448 0.0 resE 2.7.13.3 T Histidine kinase
HPPHLOHB_02449 2.3e-133 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HPPHLOHB_02450 3.9e-215 ccsA O 'COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component'
HPPHLOHB_02451 0.0 ccs1 O COG1333 ResB protein required for cytochrome c biosynthesis
HPPHLOHB_02452 1.3e-99 resA CO Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c
HPPHLOHB_02453 6.9e-133 rluB 5.4.99.19, 5.4.99.21, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
HPPHLOHB_02454 1.9e-87 spmB S Spore maturation protein
HPPHLOHB_02455 3.5e-103 spmA S Spore maturation protein
HPPHLOHB_02456 1.2e-213 dacB 3.4.16.4 M Belongs to the peptidase S11 family
HPPHLOHB_02457 4e-98 ypuI S Protein of unknown function (DUF3907)
HPPHLOHB_02458 1.9e-104 scpB D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HPPHLOHB_02459 4.5e-130 scpA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HPPHLOHB_02460 4.1e-70 ypuF S Domain of unknown function (DUF309)
HPPHLOHB_02461 4.5e-64 ribT K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HPPHLOHB_02462 3.9e-81 ribH 2.5.1.78 H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
HPPHLOHB_02463 9.8e-230 ribBA 3.5.4.25, 4.1.99.12 H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPPHLOHB_02464 1.5e-115 ribE 2.5.1.9 H Riboflavin synthase
HPPHLOHB_02465 1.3e-204 ribD 1.1.1.193, 3.5.4.26 H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPPHLOHB_02466 6e-55 ypuD
HPPHLOHB_02467 5.2e-101 sipT 3.4.21.89 U Belongs to the peptidase S26 family
HPPHLOHB_02468 2.3e-33 yhcC S nucleic-acid-binding protein containing a Zn-ribbon domain
HPPHLOHB_02469 1.5e-17 S SNARE associated Golgi protein
HPPHLOHB_02472 8e-81 ppiB 5.2.1.8 O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPPHLOHB_02473 1.3e-149 ypuA S Secreted protein
HPPHLOHB_02474 5.2e-256 lysA 4.1.1.19, 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
HPPHLOHB_02475 1.4e-273 spoVAF EG Stage V sporulation protein AF
HPPHLOHB_02476 1.4e-110 spoVAEA S stage V sporulation protein
HPPHLOHB_02477 2.2e-57 spoVAEB S stage V sporulation protein
HPPHLOHB_02478 9e-192 spoVAD I Stage V sporulation protein AD
HPPHLOHB_02479 2.3e-78 spoVAC S stage V sporulation protein AC
HPPHLOHB_02480 1e-67 spoVAB S Stage V sporulation protein AB
HPPHLOHB_02481 7.4e-112 spoVAA S Stage V sporulation protein AA
HPPHLOHB_02482 2.4e-136 sigF K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPPHLOHB_02483 1.8e-75 spoIIAB 2.7.11.1 F Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition
HPPHLOHB_02484 3.9e-57 spoIIAA T Belongs to the anti-sigma-factor antagonist family
HPPHLOHB_02485 2.8e-213 dacF 3.4.16.4 M Belongs to the peptidase S11 family
HPPHLOHB_02486 1.7e-148 punA 2.4.2.1 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HPPHLOHB_02487 1.2e-232 deoB 5.4.2.7 G Phosphotransfer between the C1 and C5 carbon atoms of pentose
HPPHLOHB_02488 2.6e-166 xerD L recombinase XerD
HPPHLOHB_02489 3.7e-37 S Protein of unknown function (DUF4227)
HPPHLOHB_02490 2.4e-80 fur P Belongs to the Fur family
HPPHLOHB_02491 2.3e-108 spoIIM S Required for complete septum migration and engulfment of the forespore compartment during sporulation. Required for stabilizing and recruiting of SpoIIP to the septal membrane
HPPHLOHB_02492 2e-32 yqkK
HPPHLOHB_02493 5.5e-242 mleA 1.1.1.38 C malic enzyme
HPPHLOHB_02494 3.1e-235 mleN C Na H antiporter
HPPHLOHB_02495 2.9e-268 aspA 4.2.1.2, 4.3.1.1 E Aspartate ammonia-lyase
HPPHLOHB_02496 3.6e-185 ansA 3.5.1.1 EJ L-asparaginase
HPPHLOHB_02497 4.5e-58 ansR K Transcriptional regulator
HPPHLOHB_02498 3e-223 yqxK 3.6.4.12 L DNA helicase
HPPHLOHB_02499 1.2e-92 nudF 3.6.1.13 L Belongs to the Nudix hydrolase family
HPPHLOHB_02501 4.4e-169 yqkF C oxidoreductases (related to aryl-alcohol dehydrogenases)
HPPHLOHB_02502 4e-14 yqkE S Protein of unknown function (DUF3886)
HPPHLOHB_02503 2.4e-175 yqkD S COG1073 Hydrolases of the alpha beta superfamily
HPPHLOHB_02504 9.4e-39 yqkC S Protein of unknown function (DUF2552)
HPPHLOHB_02505 2.8e-54 yqkB S Belongs to the HesB IscA family
HPPHLOHB_02506 4.7e-196 yqkA K GrpB protein
HPPHLOHB_02507 8e-60 yqjZ 2.3.1.128, 2.5.1.18 S enzyme involved in biosynthesis of extracellular polysaccharides
HPPHLOHB_02508 3.6e-87 yqjY K acetyltransferase
HPPHLOHB_02509 2.2e-49 S YolD-like protein
HPPHLOHB_02510 3.1e-239 polYB 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HPPHLOHB_02512 5.2e-226 yqjV G Major Facilitator Superfamily
HPPHLOHB_02514 7.2e-73 yqjT 3.1.26.4 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HPPHLOHB_02515 2.4e-178 coaA 2.7.1.33 F Pantothenic acid kinase
HPPHLOHB_02516 2.4e-264 dsdA 4.3.1.18 E Belongs to the serine threonine dehydratase family. DsdA subfamily
HPPHLOHB_02517 3.5e-143 yqjQ S Belongs to the short-chain dehydrogenases reductases (SDR) family
HPPHLOHB_02518 3.4e-180 yqjP S COG0491 Zn-dependent hydrolases, including glyoxylases
HPPHLOHB_02519 8.6e-148 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPPHLOHB_02520 0.0 rocB E arginine degradation protein
HPPHLOHB_02521 1.4e-192 namA 1.6.99.1 C Catalyzes the reduction of the double bond of an array of alpha,beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes
HPPHLOHB_02522 9.6e-146 yqjL S hydrolases or acyltransferases (alpha beta hydrolase superfamily)
HPPHLOHB_02523 2.9e-173 rnz 3.1.26.11 S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
HPPHLOHB_02524 1.6e-290 zwf 1.1.1.363, 1.1.1.49 G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPPHLOHB_02525 6.9e-267 gnd 1.1.1.343, 1.1.1.44 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPPHLOHB_02526 7.3e-236 dinB 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HPPHLOHB_02527 4.5e-24 yqzJ
HPPHLOHB_02528 5.7e-144 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HPPHLOHB_02529 3.6e-142 yqjF S Uncharacterized conserved protein (COG2071)
HPPHLOHB_02530 1.6e-202 yqjE 3.4.11.4 E COG2195 Di- and tripeptidases
HPPHLOHB_02531 4.4e-291 mmdA 2.1.3.15, 6.4.1.3 I COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
HPPHLOHB_02532 2.2e-75 mce 4.4.1.5, 5.1.99.1, 5.4.99.2 E COG0346 Lactoylglutathione lyase and related lyases
HPPHLOHB_02534 1.4e-98 yqjB S protein conserved in bacteria
HPPHLOHB_02535 1.1e-175 yqjA S Putative aromatic acid exporter C-terminal domain
HPPHLOHB_02536 2e-129 artM 3.6.3.21 E COG1126 ABC-type polar amino acid transport system, ATPase component
HPPHLOHB_02537 6.2e-109 artQ E COG0765 ABC-type amino acid transport system, permease component
HPPHLOHB_02538 6.3e-137 artP ET Belongs to the bacterial solute-binding protein 3 family
HPPHLOHB_02539 9.3e-77 yqiW S Belongs to the UPF0403 family
HPPHLOHB_02540 8.8e-167 yegS 2.7.1.107 I COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
HPPHLOHB_02541 7.9e-208 norA EGP Major facilitator Superfamily
HPPHLOHB_02542 2.6e-152 bmrR K helix_turn_helix, mercury resistance
HPPHLOHB_02543 3.5e-233 bfmBB 2.3.1.168, 2.3.1.61 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
HPPHLOHB_02544 1.8e-184 bfmBAB 1.2.4.1, 1.2.4.4 C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
HPPHLOHB_02545 1.9e-186 bfmBAA 1.2.4.4 C COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
HPPHLOHB_02546 3.4e-269 lpdA 1.8.1.4 C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
HPPHLOHB_02547 1.2e-202 buk 2.7.2.7 C Belongs to the acetokinase family
HPPHLOHB_02548 2.2e-207 ldh 1.4.1.9 E Belongs to the Glu Leu Phe Val dehydrogenases family
HPPHLOHB_02549 7.1e-156 pta 2.3.1.19, 2.3.1.8 C phosphate butyryltransferase
HPPHLOHB_02550 0.0 bkdR 2.7.13.3 KT Transcriptional regulator
HPPHLOHB_02551 4e-34 yqzF S Protein of unknown function (DUF2627)
HPPHLOHB_02552 7.1e-164 prpB 4.1.3.30 G Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HPPHLOHB_02553 5.7e-277 prpD 4.2.1.79 S 2-methylcitrate dehydratase
HPPHLOHB_02554 8.1e-210 prpC 2.3.3.1, 2.3.3.5 C Belongs to the citrate synthase family
HPPHLOHB_02555 1.8e-212 mmgC I acyl-CoA dehydrogenase
HPPHLOHB_02556 4.7e-157 hbdA 1.1.1.157 I Dehydrogenase
HPPHLOHB_02557 1.2e-219 mmgA 2.3.1.9 I Belongs to the thiolase family
HPPHLOHB_02558 1.8e-133 yqiK 3.1.4.46 C glycerophosphoryl diester phosphodiesterase
HPPHLOHB_02559 5.4e-107 amiC 3.5.1.28 M Cell wall hydrolase autolysin
HPPHLOHB_02560 5.9e-27
HPPHLOHB_02561 1.3e-215 yqiG C COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family
HPPHLOHB_02563 3.2e-144 KT May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process
HPPHLOHB_02564 1.2e-238 rseP 3.4.21.116 M Stage IV sporulation protein B
HPPHLOHB_02565 0.0 recN L May be involved in recombinational repair of damaged DNA
HPPHLOHB_02566 1.7e-78 argR K Regulates arginine biosynthesis genes
HPPHLOHB_02567 6.6e-156 rrmJ 2.1.1.226, 2.1.1.227 J rRNA methylase
HPPHLOHB_02568 0.0 dxs 2.2.1.7 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HPPHLOHB_02569 7.7e-163 ispA 2.5.1.1, 2.5.1.10, 2.5.1.29, 2.5.1.90 H Belongs to the FPP GGPP synthase family
HPPHLOHB_02570 5.8e-39 xseB 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HPPHLOHB_02571 2.2e-246 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HPPHLOHB_02572 1e-156 folD 1.5.1.5, 3.5.4.9 F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HPPHLOHB_02573 1.9e-65 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPPHLOHB_02574 2.1e-67 yqhY S protein conserved in bacteria
HPPHLOHB_02575 1.5e-255 accC 6.3.4.14, 6.4.1.2 I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
HPPHLOHB_02576 1.5e-64 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
HPPHLOHB_02577 9.9e-91 spoIIIAH S SpoIIIAH-like protein
HPPHLOHB_02578 6.9e-103 spoIIIAG S stage III sporulation protein AG
HPPHLOHB_02579 3.1e-102 spoIIIAF S Stage III sporulation protein AF (Spore_III_AF)
HPPHLOHB_02580 1.3e-197 spoIIIAE S stage III sporulation protein AE
HPPHLOHB_02581 2.3e-58 spoIIIAD S Stage III sporulation protein AD
HPPHLOHB_02582 7.6e-29 spoIIIAC S stage III sporulation protein AC
HPPHLOHB_02583 2.9e-85 spoIIIAB S Stage III sporulation protein
HPPHLOHB_02584 1.2e-171 spoIIIAA S stage III sporulation protein AA
HPPHLOHB_02585 7.9e-37 yqhV S Protein of unknown function (DUF2619)
HPPHLOHB_02586 5.4e-98 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPPHLOHB_02587 8.9e-174 yqhT 3.4.11.9, 3.4.13.9 E COG0006 Xaa-Pro aminopeptidase
HPPHLOHB_02588 1.5e-77 aroQ 4.2.1.10 E Catalyzes a trans-dehydration via an enolate intermediate
HPPHLOHB_02589 2.3e-93 yqhR S Conserved membrane protein YqhR
HPPHLOHB_02590 9.4e-175 yqhQ S Protein of unknown function (DUF1385)
HPPHLOHB_02591 2.2e-61 yqhP
HPPHLOHB_02592 8.1e-165 yqhO S esterase of the alpha-beta hydrolase superfamily
HPPHLOHB_02593 9.4e-74 mntR K Involved in manganese homeostasis. Might activate the transcription of the mntABCD operon
HPPHLOHB_02594 5.2e-161 lipM 6.3.1.20 H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation
HPPHLOHB_02595 2.3e-63 yqhL P COG0607 Rhodanese-related sulfurtransferase
HPPHLOHB_02596 2.8e-287 gcvPB 1.4.4.2 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPPHLOHB_02597 3.4e-255 gcvPA 1.4.4.2 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPPHLOHB_02598 9.6e-208 gcvT 1.4.4.2, 2.1.2.10 E The glycine cleavage system catalyzes the degradation of glycine
HPPHLOHB_02599 0.0 yqhH L COG0553 Superfamily II DNA RNA helicases, SNF2 family
HPPHLOHB_02600 2.5e-152 yqhG S Bacterial protein YqhG of unknown function
HPPHLOHB_02601 1.2e-24 sinI S Anti-repressor SinI
HPPHLOHB_02602 8.6e-54 sinR K transcriptional
HPPHLOHB_02603 2.3e-142 tasA S Cell division protein FtsN
HPPHLOHB_02604 6.7e-59 sipW 3.4.21.89 U Signal peptidase
HPPHLOHB_02605 2.1e-116 yqxM
HPPHLOHB_02606 7.3e-54 yqzG S Protein of unknown function (DUF3889)
HPPHLOHB_02607 1.4e-26 yqzE S YqzE-like protein
HPPHLOHB_02608 3.7e-42 S ComG operon protein 7
HPPHLOHB_02609 5.5e-49 comGF U Putative Competence protein ComGF
HPPHLOHB_02610 1.1e-59 comGE
HPPHLOHB_02611 4.4e-71 gspH NU protein transport across the cell outer membrane
HPPHLOHB_02612 1.4e-47 comGC U Required for transformation and DNA binding
HPPHLOHB_02613 1.6e-175 comGB NU COG1459 Type II secretory pathway, component PulF
HPPHLOHB_02614 3.9e-201 comGA NU COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPPHLOHB_02616 7.2e-175 corA P Mg2 transporter protein
HPPHLOHB_02617 5.2e-240 corC1 S COG1253 Hemolysins and related proteins containing CBS domains
HPPHLOHB_02618 1.7e-151 yqhA T COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
HPPHLOHB_02620 2.7e-64 yqgZ 1.20.4.1 P Belongs to the ArsC family
HPPHLOHB_02621 1.8e-37 yqgY S Protein of unknown function (DUF2626)
HPPHLOHB_02622 1.9e-123 ycbL 3.1.2.6 S COG0491 Zn-dependent hydrolases, including glyoxylases
HPPHLOHB_02623 8.9e-23 yqgW S Protein of unknown function (DUF2759)
HPPHLOHB_02624 6.9e-50 yqgV S Thiamine-binding protein
HPPHLOHB_02625 2.7e-199 yqgU
HPPHLOHB_02626 1.4e-222 yqgT 3.4.19.11 E Gamma-D-glutamyl-L-diamino acid endopeptidase
HPPHLOHB_02627 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
HPPHLOHB_02628 5.2e-181 glcK 2.7.1.2 G Glucokinase
HPPHLOHB_02629 3.1e-33 yqgQ S Protein conserved in bacteria
HPPHLOHB_02630 1.4e-268 gluP 3.4.21.105 O membrane protein (homolog of Drosophila rhomboid)
HPPHLOHB_02631 2.5e-09 yqgO
HPPHLOHB_02632 2.7e-105 ygfA 6.3.3.2 H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPPHLOHB_02633 9.4e-21 rpmG J Belongs to the bacterial ribosomal protein bL33 family
HPPHLOHB_02634 3.2e-203 yqgM 2.4.1.11, 2.4.1.18 GH57,GT4 M Glycosyl transferases group 1
HPPHLOHB_02636 9.2e-51 yqzD
HPPHLOHB_02637 1.9e-75 yqzC S YceG-like family
HPPHLOHB_02638 9.8e-146 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
HPPHLOHB_02639 6.4e-148 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
HPPHLOHB_02640 4.4e-158 pstA P Phosphate transport system permease
HPPHLOHB_02641 1.3e-160 pstC P probably responsible for the translocation of the substrate across the membrane
HPPHLOHB_02642 5.3e-151 pstS P Phosphate
HPPHLOHB_02643 0.0 pbpA 3.4.16.4 M penicillin-binding protein
HPPHLOHB_02644 2.5e-231 yqgE EGP Major facilitator superfamily
HPPHLOHB_02645 6.3e-116 sodA 1.15.1.1 P radicals which are normally produced within the cells and which are toxic to biological systems
HPPHLOHB_02646 4e-73 yqgC S protein conserved in bacteria
HPPHLOHB_02647 8.5e-134 yqgB S Protein of unknown function (DUF1189)
HPPHLOHB_02648 2.2e-75 yqgA
HPPHLOHB_02649 5.2e-47 yqfZ M LysM domain
HPPHLOHB_02650 2.8e-202 ispG 1.17.7.1, 1.17.7.3 I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HPPHLOHB_02651 4.3e-62 yqfX S membrane
HPPHLOHB_02652 1.2e-108 yqfW S Belongs to the 5'(3')-deoxyribonucleotidase family
HPPHLOHB_02653 1.9e-77 zur P Belongs to the Fur family
HPPHLOHB_02654 1.6e-157 yqfU S Uncharacterized protein conserved in bacteria (DUF2179)
HPPHLOHB_02655 2.1e-36 yqfT S Protein of unknown function (DUF2624)
HPPHLOHB_02656 8.8e-167 nfo 3.1.21.2 L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HPPHLOHB_02657 1.7e-243 cshB 3.6.4.13 JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
HPPHLOHB_02658 2.9e-14 yqfQ S YqfQ-like protein
HPPHLOHB_02659 2.6e-177 ispH 1.17.7.4, 2.7.4.25 IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HPPHLOHB_02660 5.1e-212 yqfO 3.5.4.16 S Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPPHLOHB_02661 6.1e-117 trmK 2.1.1.217 S SAM-dependent methyltransferase
HPPHLOHB_02662 1.6e-61 cccA C COG2010 Cytochrome c, mono- and diheme variants
HPPHLOHB_02663 1.2e-200 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
HPPHLOHB_02664 0.0 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
HPPHLOHB_02665 4.5e-88 yaiI S Belongs to the UPF0178 family
HPPHLOHB_02666 5.8e-149 yqfL 2.7.11.33, 2.7.4.28 S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation
HPPHLOHB_02667 4.5e-112 ccpN K CBS domain
HPPHLOHB_02668 0.0 glyS 6.1.1.14 J Glycyl-tRNA synthetase beta subunit
HPPHLOHB_02669 3.3e-174 glyQ 6.1.1.14 J glycyl-tRNA synthetase alpha subunit
HPPHLOHB_02670 4.8e-145 recO L Involved in DNA repair and RecF pathway recombination
HPPHLOHB_02671 8.4e-19 S YqzL-like protein
HPPHLOHB_02672 3.1e-167 era S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPPHLOHB_02673 7.1e-71 cdd 2.4.2.2, 3.5.4.5 F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
HPPHLOHB_02674 1.6e-61 dgkA 2.7.1.107, 2.7.1.66 M Diacylglycerol kinase
HPPHLOHB_02675 5.1e-81 ybeY 2.6.99.2, 3.5.4.5 S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HPPHLOHB_02676 0.0 yqfF S membrane-associated HD superfamily hydrolase
HPPHLOHB_02678 1.1e-175 phoH T Phosphate starvation-inducible protein PhoH
HPPHLOHB_02679 1.5e-185 yqfD 3.1.3.102, 3.1.3.104 S Stage IV sporulation
HPPHLOHB_02680 2.7e-45 yqfC S sporulation protein YqfC
HPPHLOHB_02681 6e-25 yqfB
HPPHLOHB_02682 4.3e-122 yqfA S UPF0365 protein
HPPHLOHB_02683 5.4e-229 yqeZ O COG1030 Membrane-bound serine protease (ClpP class)
HPPHLOHB_02684 2.5e-61 yqeY S Yqey-like protein
HPPHLOHB_02685 1.2e-19 rpsU J Belongs to the bacterial ribosomal protein bS21 family
HPPHLOHB_02686 1.6e-158 yqeW P COG1283 Na phosphate symporter
HPPHLOHB_02687 2.1e-260 yqeV 2.8.4.5 J ribosomal protein S12 methylthiotransferase
HPPHLOHB_02688 1.4e-141 rsmE 2.1.1.193 J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
HPPHLOHB_02689 5.4e-175 prmA J Methylates ribosomal protein L11
HPPHLOHB_02690 4.2e-182 dnaJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
HPPHLOHB_02691 0.0 dnaK O Heat shock 70 kDa protein
HPPHLOHB_02692 3.8e-75 grpE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPPHLOHB_02693 4.7e-188 hrcA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
HPPHLOHB_02694 4.8e-218 hemN H Involved in the biosynthesis of porphyrin-containing compound
HPPHLOHB_02695 0.0 lepA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
HPPHLOHB_02696 1e-54 yqxA S Protein of unknown function (DUF3679)
HPPHLOHB_02697 6.9e-223 spoIIP M stage II sporulation protein P
HPPHLOHB_02698 1.3e-204 gpr 3.4.24.78 C Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HPPHLOHB_02699 9.7e-37 rpsT J Binds directly to 16S ribosomal RNA
HPPHLOHB_02700 1.1e-189 holA 2.7.7.7 L DNA polymerase III delta subunit
HPPHLOHB_02701 4.1e-15 S YqzM-like protein
HPPHLOHB_02702 0.0 comEC S Competence protein ComEC
HPPHLOHB_02703 2.1e-105 comEB 3.5.4.12 F ComE operon protein 2
HPPHLOHB_02704 3e-105 wza L COG1555 DNA uptake protein and related DNA-binding proteins
HPPHLOHB_02705 8.4e-148 comER E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPPHLOHB_02706 2.9e-139 yqeM Q Methyltransferase
HPPHLOHB_02707 6.9e-62 rsfS J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
HPPHLOHB_02708 7.4e-103 nadD 2.7.6.3, 2.7.7.18 H HD superfamily hydrolase involved in NAD metabolism
HPPHLOHB_02709 2.7e-108 nadD 2.7.7.18, 3.6.1.55 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HPPHLOHB_02710 2.1e-45 yhbY J RNA-binding protein containing KH domain, possibly ribosomal protein
HPPHLOHB_02711 2.7e-157 aroE 1.1.1.25 E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPPHLOHB_02712 9.1e-214 yqeH S In Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis
HPPHLOHB_02713 5.3e-95 yqeG S hydrolase of the HAD superfamily
HPPHLOHB_02715 6.2e-142 yqeF E GDSL-like Lipase/Acylhydrolase
HPPHLOHB_02716 2.1e-137 xlyA 3.5.1.28 M n-acetylmuramoyl-L-alanine amidase
HPPHLOHB_02717 4.7e-106 yqeD S SNARE associated Golgi protein
HPPHLOHB_02718 1.2e-171 gnd 1.1.1.343, 1.1.1.44 G 6-phosphogluconate dehydrogenase
HPPHLOHB_02719 2.3e-133 yqeB
HPPHLOHB_02720 1.1e-74 nucB M Deoxyribonuclease NucA/NucB
HPPHLOHB_02721 3.3e-56 sigK K sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPPHLOHB_02722 1.4e-281 cisA2 L Recombinase
HPPHLOHB_02723 1.8e-77 arsC 1.20.4.1 T Catalyzes the reduction of arsenate As(V) to arsenite As(III)
HPPHLOHB_02724 6e-183 arsB 1.20.4.1 P Arsenic resistance protein
HPPHLOHB_02725 2.8e-73 cadI 4.4.1.5 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HPPHLOHB_02726 1.6e-54 arsR K ArsR family transcriptional regulator
HPPHLOHB_02727 1.1e-152 yqcI S YqcI/YcgG family
HPPHLOHB_02728 1.6e-96 S Tetratricopeptide repeat
HPPHLOHB_02731 3.8e-277 A Pre-toxin TG
HPPHLOHB_02732 1.1e-104 S Suppressor of fused protein (SUFU)
HPPHLOHB_02734 5e-60
HPPHLOHB_02736 1.1e-144 xlyA 3.5.1.28 M N-acetylmuramoyl-L-alanine amidase
HPPHLOHB_02737 2.6e-68 S Bacteriophage holin family
HPPHLOHB_02738 4.8e-165 xepA
HPPHLOHB_02739 1.3e-23
HPPHLOHB_02740 4.1e-56 xkdW S XkdW protein
HPPHLOHB_02741 2e-221
HPPHLOHB_02742 9.6e-40
HPPHLOHB_02743 9.9e-103 xkdU S Uncharacterised protein conserved in bacteria (DUF2313)
HPPHLOHB_02744 6e-191 xkdT S Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
HPPHLOHB_02745 9.6e-71 xkdS S Protein of unknown function (DUF2634)
HPPHLOHB_02746 1.8e-38 xkdR S Protein of unknown function (DUF2577)
HPPHLOHB_02747 2.4e-181 yqbQ 3.2.1.96 G NLP P60 protein
HPPHLOHB_02748 9e-114 xkdP S Lysin motif
HPPHLOHB_02749 0.0 xkdO L Transglycosylase SLT domain
HPPHLOHB_02750 1.8e-67 S Phage XkdN-like tail assembly chaperone protein, TAC
HPPHLOHB_02752 3.6e-76 xkdM S Phage tail tube protein
HPPHLOHB_02753 5.5e-256 xkdK S Phage tail sheath C-terminal domain
HPPHLOHB_02754 3.2e-26
HPPHLOHB_02755 1.4e-77
HPPHLOHB_02756 4.3e-94 S Bacteriophage HK97-gp10, putative tail-component
HPPHLOHB_02757 6.7e-65 yqbH S Domain of unknown function (DUF3599)
HPPHLOHB_02758 2.1e-67 S Protein of unknown function (DUF3199)
HPPHLOHB_02759 3.6e-51 S YqbF, hypothetical protein domain
HPPHLOHB_02760 1.9e-167 xkdG S Phage capsid family
HPPHLOHB_02761 5.1e-128 yqbD 2.1.1.72 L Putative phage serine protease XkdF
HPPHLOHB_02762 2e-115
HPPHLOHB_02763 5.7e-169 S Phage Mu protein F like protein
HPPHLOHB_02764 5.9e-296 yqbA S portal protein
HPPHLOHB_02765 2.4e-253 S phage terminase, large subunit
HPPHLOHB_02766 6.3e-107 yqaS L DNA packaging
HPPHLOHB_02768 6.5e-81 L Transposase
HPPHLOHB_02769 1.6e-166
HPPHLOHB_02770 2.1e-31 yqaO S Phage-like element PBSX protein XtrA
HPPHLOHB_02771 7.2e-74 rusA L Endodeoxyribonuclease RusA
HPPHLOHB_02773 5.9e-168 xkdC L IstB-like ATP binding protein
HPPHLOHB_02774 4.7e-123 3.1.3.16 L DnaD domain protein
HPPHLOHB_02775 2.5e-155 recT L RecT family
HPPHLOHB_02776 1.5e-180 yqaJ L YqaJ-like viral recombinase domain
HPPHLOHB_02780 1.2e-103
HPPHLOHB_02782 6.5e-37 K Helix-turn-helix XRE-family like proteins
HPPHLOHB_02783 1.1e-56 K sequence-specific DNA binding
HPPHLOHB_02785 1e-101 adk 2.7.4.3 F adenylate kinase activity
HPPHLOHB_02786 1.4e-100 yqaB E IrrE N-terminal-like domain
HPPHLOHB_02787 2.2e-61 sigK K sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPPHLOHB_02788 2e-68 psiE S Protein PsiE homolog
HPPHLOHB_02789 9e-237 yrkQ T Histidine kinase
HPPHLOHB_02790 1.1e-127 T Transcriptional regulator
HPPHLOHB_02791 8.2e-224 yrkO P Protein of unknown function (DUF418)
HPPHLOHB_02792 6e-105 yrkN K Acetyltransferase (GNAT) family
HPPHLOHB_02793 1.5e-97 ywrO S Flavodoxin-like fold
HPPHLOHB_02794 2.8e-79 S Protein of unknown function with HXXEE motif
HPPHLOHB_02795 4.3e-117 yrkJ S membrane transporter protein
HPPHLOHB_02796 2.4e-36 yrkI O Belongs to the sulfur carrier protein TusA family
HPPHLOHB_02797 2.3e-212 yrkH P Rhodanese Homology Domain
HPPHLOHB_02798 1.7e-99 yrkF OP Belongs to the sulfur carrier protein TusA family
HPPHLOHB_02799 5.1e-84 yrkE O DsrE/DsrF/DrsH-like family
HPPHLOHB_02800 7.8e-39 yrkD S protein conserved in bacteria
HPPHLOHB_02801 2.6e-108 yrkC G Cupin domain
HPPHLOHB_02803 4.8e-151 bltR K helix_turn_helix, mercury resistance
HPPHLOHB_02804 3.5e-211 blt EGP Major facilitator Superfamily
HPPHLOHB_02805 1.4e-83 bltD 2.3.1.57 K FR47-like protein
HPPHLOHB_02806 4.5e-236 corC1 S COG1253 Hemolysins and related proteins containing CBS domains
HPPHLOHB_02807 2.1e-17 S YrzO-like protein
HPPHLOHB_02808 1.7e-171 yrdR EG EamA-like transporter family
HPPHLOHB_02809 5.9e-160 yrdQ K Transcriptional regulator
HPPHLOHB_02810 2e-199 trkA P Oxidoreductase
HPPHLOHB_02811 3.5e-158 czcD P COG1230 Co Zn Cd efflux system component
HPPHLOHB_02812 1.3e-66 yodA S tautomerase
HPPHLOHB_02813 7.7e-163 gltR K LysR substrate binding domain
HPPHLOHB_02815 1.5e-231 brnQ E Component of the transport system for branched-chain amino acids
HPPHLOHB_02816 2.5e-50 azlD E Branched-chain amino acid transport protein (AzlD)
HPPHLOHB_02817 3.3e-138 azlC E AzlC protein
HPPHLOHB_02818 2.2e-79 bkdR K helix_turn_helix ASNC type
HPPHLOHB_02819 4.1e-46 yrdF K ribonuclease inhibitor
HPPHLOHB_02820 4.1e-231 cypA C Cytochrome P450
HPPHLOHB_02822 3.1e-101 yrdC 3.5.1.19 Q Isochorismatase family
HPPHLOHB_02823 1.9e-57 S Protein of unknown function (DUF2568)
HPPHLOHB_02824 1.2e-91 yrdA S DinB family
HPPHLOHB_02825 7.6e-168 aadK G Streptomycin adenylyltransferase
HPPHLOHB_02826 1.5e-194 yrpB 1.13.12.16 S COG2070 Dioxygenases related to 2-nitropropane dioxygenase
HPPHLOHB_02827 7.4e-149 murI 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
HPPHLOHB_02828 3e-125 yrpD S Domain of unknown function, YrpD
HPPHLOHB_02830 5.4e-117 adcA S ZinT (YodA) periplasmic lipocalin-like zinc-recruitment
HPPHLOHB_02831 6.3e-96 sigZ K Belongs to the sigma-70 factor family. ECF subfamily
HPPHLOHB_02832 4.5e-188 yrpG C Aldo/keto reductase family
HPPHLOHB_02833 9.5e-226 yraO C Citrate transporter
HPPHLOHB_02834 1.2e-163 yraN K Transcriptional regulator
HPPHLOHB_02835 2.4e-206 yraM S PrpF protein
HPPHLOHB_02837 2.7e-157 csn 3.2.1.132 M Aids in the defense against invading fungal pathogens by degrading their cell wall chitosan
HPPHLOHB_02838 7.6e-42 yraL S COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HPPHLOHB_02839 3.2e-155 S Alpha beta hydrolase
HPPHLOHB_02840 1.7e-60 T sh3 domain protein
HPPHLOHB_02841 2.4e-61 T sh3 domain protein
HPPHLOHB_02842 1.3e-66 E Glyoxalase-like domain
HPPHLOHB_02843 5.3e-37 yraG
HPPHLOHB_02844 6.4e-63 yraF M Spore coat protein
HPPHLOHB_02845 2.9e-223 adhB 1.1.1.1, 1.1.1.14, 1.1.1.284, 1.2.1.46 E COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
HPPHLOHB_02846 2.6e-26 yraE
HPPHLOHB_02847 1.1e-49 yraD M Spore coat protein
HPPHLOHB_02848 4.3e-47 yraB K helix_turn_helix, mercury resistance
HPPHLOHB_02849 3.2e-29 yphJ 4.1.1.44 S peroxiredoxin activity
HPPHLOHB_02850 1.9e-200 adhA 1.1.1.1 C alcohol dehydrogenase
HPPHLOHB_02851 5e-90 yhbO 1.11.1.6, 3.5.1.124 S protease
HPPHLOHB_02852 0.0 sacC 3.2.1.26, 3.2.1.65, 3.2.1.80 GH32 G Belongs to the glycosyl hydrolase 32 family
HPPHLOHB_02853 1.5e-152 manZ G COG3716 Phosphotransferase system, mannose fructose N-acetylgalactosamine-specific component IID
HPPHLOHB_02854 4.9e-116 manY G COG3715 Phosphotransferase system, mannose fructose N-acetylgalactosamine-specific component IIC
HPPHLOHB_02855 6.3e-82 levE 2.7.1.202 G PTS system mannose fructose sorbose family
HPPHLOHB_02856 3.9e-75 levD 2.7.1.202 G PTS system fructose IIA component
HPPHLOHB_02857 0.0 levR K PTS system fructose IIA component
HPPHLOHB_02858 1.6e-255 cycA E COG1113 Gamma-aminobutyrate permease and related permeases
HPPHLOHB_02859 3.6e-106 yrhP E LysE type translocator
HPPHLOHB_02860 1.1e-150 yrhO K Archaeal transcriptional regulator TrmB
HPPHLOHB_02861 4.3e-86 sigV K Belongs to the sigma-70 factor family. ECF subfamily
HPPHLOHB_02862 1.7e-151 rsiV S Protein of unknown function (DUF3298)
HPPHLOHB_02863 0.0 yrhL I Acyltransferase family
HPPHLOHB_02864 1.5e-46 yrhK S YrhK-like protein
HPPHLOHB_02865 0.0 cypD 1.14.14.1, 1.6.2.4 C Belongs to the cytochrome P450 family
HPPHLOHB_02866 4.8e-105 Z012_03230 K Tetracycline repressor, C-terminal all-alpha domain
HPPHLOHB_02867 4.5e-97 yrhH Q methyltransferase
HPPHLOHB_02870 1.8e-142 focA P Formate nitrite
HPPHLOHB_02871 7.8e-61 yrhF S Uncharacterized conserved protein (DUF2294)
HPPHLOHB_02872 0.0 fdhA 1.17.1.10, 1.17.1.9 C formate dehydrogenase (NAD+) activity
HPPHLOHB_02873 1.4e-78 yrhD S Protein of unknown function (DUF1641)
HPPHLOHB_02874 4.6e-35 yrhC S YrhC-like protein
HPPHLOHB_02875 2.6e-211 mccB 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
HPPHLOHB_02876 1.2e-171 mccA 2.5.1.134, 2.5.1.47 E Cysteine synthase
HPPHLOHB_02877 4.2e-124 mtnN 3.2.2.9 E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPPHLOHB_02878 1.2e-120 yrrT 4.4.1.21 Q Could be a S-adenosyl-L-methionine-dependent methyltransferase
HPPHLOHB_02879 7e-27 yrzA S Protein of unknown function (DUF2536)
HPPHLOHB_02880 4.2e-63 yrrS S Protein of unknown function (DUF1510)
HPPHLOHB_02881 0.0 pbpI 3.4.16.4 M Penicillin-binding Protein
HPPHLOHB_02882 2.4e-78 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
HPPHLOHB_02883 4.7e-114 udk 2.7.1.48 F Cytidine monophosphokinase
HPPHLOHB_02884 2.7e-246 yegQ O COG0826 Collagenase and related proteases
HPPHLOHB_02885 7.8e-174 yegQ O Peptidase U32
HPPHLOHB_02886 5.9e-120 yrrM 2.1.1.104 S O-methyltransferase
HPPHLOHB_02887 1.6e-183 mltG S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPPHLOHB_02888 1.2e-45 yrzB S Belongs to the UPF0473 family
HPPHLOHB_02889 2.1e-70 yqgF L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HPPHLOHB_02890 1.7e-41 yrzL S Belongs to the UPF0297 family
HPPHLOHB_02891 0.0 alaS 6.1.1.7 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPPHLOHB_02892 2.7e-170 yrrI S AI-2E family transporter
HPPHLOHB_02893 1.3e-131 glnQ 3.6.3.21 E COG1126 ABC-type polar amino acid transport system, ATPase component
HPPHLOHB_02894 5.1e-145 glnH ET Belongs to the bacterial solute-binding protein 3 family
HPPHLOHB_02895 3.6e-109 gluC P ABC transporter
HPPHLOHB_02896 7.6e-107 glnP P ABC transporter
HPPHLOHB_02897 8e-08 S Protein of unknown function (DUF3918)
HPPHLOHB_02898 9.8e-31 yrzR
HPPHLOHB_02899 1.8e-83 yrrD S protein conserved in bacteria
HPPHLOHB_02900 0.0 recD2 3.1.11.5 L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
HPPHLOHB_02901 1.4e-15 S COG0457 FOG TPR repeat
HPPHLOHB_02902 2.3e-220 mnmA 2.8.1.13 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
HPPHLOHB_02903 4.7e-213 iscS 2.8.1.7 E Cysteine desulfurase
HPPHLOHB_02904 1.2e-70 cymR K Transcriptional regulator
HPPHLOHB_02905 2e-236 rarA L COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase
HPPHLOHB_02906 2.8e-137 yrvM H COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1
HPPHLOHB_02907 0.0 aspS 6.1.1.12 J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HPPHLOHB_02908 5.2e-245 hisS 6.1.1.21 J histidyl-tRNA synthetase
HPPHLOHB_02910 3.9e-263 lytH 3.5.1.28 M COG3103 SH3 domain protein
HPPHLOHB_02911 1.9e-68 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
HPPHLOHB_02912 0.0 relA 2.7.6.5 KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPPHLOHB_02913 5.9e-91 apt 2.4.2.22, 2.4.2.7 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPPHLOHB_02914 0.0 recJ L Single-stranded-DNA-specific exonuclease RecJ
HPPHLOHB_02915 1.3e-48 yrvD S Lipopolysaccharide assembly protein A domain
HPPHLOHB_02916 1.7e-87 yrvC P regulatory, ligand-binding protein related to C-terminal domains of K channels
HPPHLOHB_02917 0.0 secF U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPPHLOHB_02918 9.4e-49 yrzD S Post-transcriptional regulator
HPPHLOHB_02919 5.7e-270 spoVB S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
HPPHLOHB_02920 2.2e-114 yrbG S membrane
HPPHLOHB_02921 1.2e-74 yrzE S Protein of unknown function (DUF3792)
HPPHLOHB_02922 1.1e-38 yajC U Preprotein translocase subunit YajC
HPPHLOHB_02923 5.2e-228 tgt 2.4.2.29 F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
HPPHLOHB_02924 2e-194 queA 2.4.99.17 J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HPPHLOHB_02925 2.6e-18 yrzS S Protein of unknown function (DUF2905)
HPPHLOHB_02926 6.6e-187 ruvB 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
HPPHLOHB_02927 1.6e-106 ruvA 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
HPPHLOHB_02928 4.8e-93 bofC S BofC C-terminal domain
HPPHLOHB_02929 5.3e-253 csbX EGP Major facilitator Superfamily
HPPHLOHB_02930 1.3e-193 iolG 1.1.1.18, 1.1.1.369 S Oxidoreductase family, NAD-binding Rossmann fold
HPPHLOHB_02931 6.5e-119 yrzF T serine threonine protein kinase
HPPHLOHB_02933 2.6e-35 S Family of unknown function (DUF5412)
HPPHLOHB_02934 1.8e-262 alsT E Sodium alanine symporter
HPPHLOHB_02935 1.9e-127 yebC K transcriptional regulatory protein
HPPHLOHB_02936 3.8e-49 S Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
HPPHLOHB_02937 9.8e-158 safA M spore coat assembly protein SafA
HPPHLOHB_02938 2.8e-215 nadA 2.5.1.72 H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HPPHLOHB_02939 5.4e-161 nadC 1.4.3.16, 2.4.2.19 H Belongs to the NadC ModD family
HPPHLOHB_02940 2.7e-307 nadB 1.3.5.4, 1.4.3.16 H Catalyzes the oxidation of L-aspartate to iminoaspartate
HPPHLOHB_02941 1.2e-230 nifS 2.8.1.7 E Cysteine desulfurase
HPPHLOHB_02942 3.6e-94 niaR S small molecule binding protein (contains 3H domain)
HPPHLOHB_02943 3.4e-163 pheA 4.2.1.51 E Prephenate dehydratase
HPPHLOHB_02944 2.2e-73 pheB 5.4.99.5 S Belongs to the UPF0735 family
HPPHLOHB_02945 1.5e-231 obg S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPPHLOHB_02946 1.5e-106 spo0B T Sporulation initiation phospho-transferase B, C-terminal
HPPHLOHB_02947 2.5e-46 rpmA J Belongs to the bacterial ribosomal protein bL27 family
HPPHLOHB_02948 4.1e-56 ysxB J ribosomal protein
HPPHLOHB_02949 5.8e-49 rplU J This protein binds to 23S rRNA in the presence of protein L20
HPPHLOHB_02950 9.2e-161 spoIVFB S Stage IV sporulation protein
HPPHLOHB_02951 3.8e-145 spoIVFA M COG0739 Membrane proteins related to metalloendopeptidases
HPPHLOHB_02952 2.5e-144 minD D Belongs to the ParA family
HPPHLOHB_02953 1.4e-108 minC D Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization
HPPHLOHB_02954 1.4e-84 mreD M shape-determining protein
HPPHLOHB_02955 2.8e-157 mreC M Involved in formation and maintenance of cell shape
HPPHLOHB_02956 1.8e-184 mreB D Rod shape-determining protein MreB
HPPHLOHB_02957 5.9e-126 radC E Belongs to the UPF0758 family
HPPHLOHB_02958 2.8e-102 maf D septum formation protein Maf
HPPHLOHB_02959 1.1e-168 spoIIB S Sporulation related domain
HPPHLOHB_02960 6.6e-85 comC 3.4.23.43 NOU COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases
HPPHLOHB_02961 4.3e-247 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
HPPHLOHB_02962 0.0 valS 6.1.1.9 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
HPPHLOHB_02963 1.6e-25
HPPHLOHB_02964 1.6e-199 ysxE S A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPPHLOHB_02965 1.9e-226 spoVID M stage VI sporulation protein D
HPPHLOHB_02966 4.6e-249 hemL 5.4.3.8 H Glutamate-1-semialdehyde aminotransferase
HPPHLOHB_02967 5.6e-183 hemB 4.2.1.24 H Belongs to the ALAD family
HPPHLOHB_02968 4.4e-146 hemD 2.1.1.107, 4.2.1.75 H Uroporphyrinogen-III synthase
HPPHLOHB_02969 3e-173 hemC 2.1.1.107, 2.5.1.61, 4.2.1.75 H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
HPPHLOHB_02970 3.6e-146 hemX O cytochrome C
HPPHLOHB_02971 3.5e-247 hemA 1.2.1.70 H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HPPHLOHB_02972 1.4e-89 ysxD
HPPHLOHB_02973 1.2e-106 engB D Necessary for normal cell division and for the maintenance of normal septation
HPPHLOHB_02974 0.0 lon 3.4.21.53 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPPHLOHB_02975 2.3e-311 lonB 2.7.7.7, 3.4.21.53 LO Belongs to the peptidase S16 family
HPPHLOHB_02976 3.4e-233 clpX O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPPHLOHB_02977 8.3e-227 tig D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
HPPHLOHB_02978 2.3e-187 ysoA H Tetratricopeptide repeat
HPPHLOHB_02979 8.1e-116 leuD 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HPPHLOHB_02980 1.7e-276 leuC 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HPPHLOHB_02981 3.3e-200 leuB 1.1.1.85 CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
HPPHLOHB_02982 4e-292 leuA 2.3.3.13 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPPHLOHB_02983 3.1e-192 ilvC 1.1.1.86 EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HPPHLOHB_02984 3.2e-84 ilvN 2.2.1.6 E Acetolactate synthase
HPPHLOHB_02985 0.0 ilvB 2.2.1.6 E Acetolactate synthase
HPPHLOHB_02987 7.6e-82 ysnE K acetyltransferase
HPPHLOHB_02988 9.1e-134 ysnF S protein conserved in bacteria
HPPHLOHB_02990 1.4e-92 ysnB S Phosphoesterase
HPPHLOHB_02991 4.5e-103 rdgB 3.6.1.66 F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPPHLOHB_02992 1.8e-133 rph 2.7.7.56, 3.6.1.66 J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HPPHLOHB_02993 2.9e-196 gerM S COG5401 Spore germination protein
HPPHLOHB_02994 2.1e-154 murI 3.6.1.66, 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
HPPHLOHB_02995 2.3e-75 ysmB 2.4.2.28 K helix_turn_helix multiple antibiotic resistance protein
HPPHLOHB_02996 3.3e-30 gerE K Transcriptional regulator
HPPHLOHB_02997 7.7e-79 ybgC 3.1.2.23, 3.1.2.28 S thioesterase
HPPHLOHB_02998 4.6e-148 sdhB 1.3.5.1, 1.3.5.4 C succinate dehydrogenase
HPPHLOHB_02999 0.0 sdhA 1.3.5.1, 1.3.5.4 C succinate dehydrogenase
HPPHLOHB_03000 2.4e-107 sdhC C succinate dehydrogenase
HPPHLOHB_03001 1.2e-79 yslB S Protein of unknown function (DUF2507)
HPPHLOHB_03002 1.3e-216 lysC 1.1.1.3, 2.7.2.4 E Belongs to the aspartokinase family
HPPHLOHB_03003 0.0 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
HPPHLOHB_03004 2e-52 trxA O Belongs to the thioredoxin family
HPPHLOHB_03005 4e-305 xsa 3.2.1.55 GH51 G Alpha-L-arabinofuranosidase C-terminus
HPPHLOHB_03007 4.2e-178 etfA C Electron transfer flavoprotein
HPPHLOHB_03008 1.2e-135 etfB C Electron transfer flavoprotein
HPPHLOHB_03009 3.1e-136 fadB 4.2.1.17 I Belongs to the enoyl-CoA hydratase isomerase family
HPPHLOHB_03010 2.7e-100 fadR K Transcriptional regulator
HPPHLOHB_03011 0.0 lcfA 6.2.1.3 IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
HPPHLOHB_03012 7.3e-68 yshE S membrane
HPPHLOHB_03013 0.0 mutS2 L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
HPPHLOHB_03014 0.0 polX L COG1796 DNA polymerase IV (family X)
HPPHLOHB_03015 1.3e-85 cvpA S membrane protein, required for colicin V production
HPPHLOHB_03016 2.4e-40 zapA D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HPPHLOHB_03017 4e-170 rnhC 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPPHLOHB_03018 0.0 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HPPHLOHB_03019 2.8e-196 pheS 6.1.1.20 J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HPPHLOHB_03020 3.1e-133 spoU 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPPHLOHB_03021 2.6e-32 sspI S Belongs to the SspI family
HPPHLOHB_03022 4.4e-208 ysfB KT regulator
HPPHLOHB_03023 7.2e-264 glcD 1.1.3.15 C Glycolate oxidase subunit
HPPHLOHB_03024 5.6e-258 glcF C Glycolate oxidase
HPPHLOHB_03025 3.6e-38 ysfE 4.4.1.5 E lactoylglutathione lyase activity
HPPHLOHB_03027 0.0 cstA T Carbon starvation protein
HPPHLOHB_03028 4.6e-301 abfA 3.2.1.55 GH51 G alpha-L-arabinofuranosidase activity
HPPHLOHB_03029 3.4e-144 araQ G transport system permease
HPPHLOHB_03030 1.4e-167 araP G carbohydrate transport
HPPHLOHB_03031 2.8e-254 araN G carbohydrate transport
HPPHLOHB_03032 5e-226 egsA 1.1.1.261 I Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is probably used for the synthesis of phosphoglycerolipids in Gram-positive bacterial species
HPPHLOHB_03033 4.1e-147 araL 3.1.3.41 G Haloacid dehalogenase-like hydrolase
HPPHLOHB_03034 8.4e-133 araD 4.1.2.17, 4.2.1.109, 5.1.3.4 G COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases
HPPHLOHB_03035 0.0 araB 2.7.1.16 C Belongs to the ribulokinase family
HPPHLOHB_03036 1.9e-294 araA 5.3.1.4 G Catalyzes the conversion of L-arabinose to L-ribulose
HPPHLOHB_03037 2.1e-190 abnA 3.2.1.99 GH43 G Belongs to the glycosyl hydrolase 43 family
HPPHLOHB_03038 4.5e-205 ysdC G COG1363 Cellulase M and related proteins
HPPHLOHB_03039 9.2e-68 ysdB S Sigma-w pathway protein YsdB
HPPHLOHB_03040 7.5e-45 ysdA S Membrane
HPPHLOHB_03041 3.6e-58 rplT J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HPPHLOHB_03042 9e-27 rpmI J Belongs to the bacterial ribosomal protein bL35 family
HPPHLOHB_03043 3.3e-86 infC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HPPHLOHB_03045 2.4e-111 lrgB M Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses
HPPHLOHB_03046 2.2e-49 lrgA S Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses
HPPHLOHB_03047 6.3e-131 lytT T COG3279 Response regulator of the LytR AlgR family
HPPHLOHB_03048 0.0 lytS 2.7.13.3 T Histidine kinase
HPPHLOHB_03049 1.5e-149 ysaA S HAD-hyrolase-like
HPPHLOHB_03050 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HPPHLOHB_03051 3.8e-159 ytxC S YtxC-like family
HPPHLOHB_03052 4.9e-111 ytxB S SNARE associated Golgi protein
HPPHLOHB_03053 3e-173 dnaI L Primosomal protein DnaI
HPPHLOHB_03054 3.5e-266 dnaB L Membrane attachment protein
HPPHLOHB_03055 1.1e-80 nrdR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HPPHLOHB_03056 2e-67 speH 4.1.1.50 E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HPPHLOHB_03057 2.8e-193 gapB 1.2.1.12, 1.2.1.59 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
HPPHLOHB_03058 9.9e-67 ytcD K Transcriptional regulator
HPPHLOHB_03059 4.9e-205 ytbD EGP Major facilitator Superfamily
HPPHLOHB_03060 8.9e-161 ytbE S reductase
HPPHLOHB_03061 7.6e-98 coaE 2.7.1.24 F Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPPHLOHB_03062 1.1e-107 ytaF P Probably functions as a manganese efflux pump
HPPHLOHB_03063 2e-157 fpg 3.2.2.23, 4.2.99.18 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
HPPHLOHB_03064 0.0 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPPHLOHB_03065 0.0 phoR 2.7.13.3 T Signal transduction histidine kinase
HPPHLOHB_03066 2.2e-131 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HPPHLOHB_03067 1.1e-170 mdh 1.1.1.37 C Catalyzes the reversible oxidation of malate to oxaloacetate
HPPHLOHB_03068 1.8e-242 icd 1.1.1.42 C isocitrate
HPPHLOHB_03069 4.7e-210 citZ 2.3.3.1 C Belongs to the citrate synthase family
HPPHLOHB_03070 4.7e-71 yeaL S membrane
HPPHLOHB_03071 2.6e-192 ytvI S sporulation integral membrane protein YtvI
HPPHLOHB_03072 1.8e-63 fxsA S COG3030 Protein affecting phage T7 exclusion by the F plasmid
HPPHLOHB_03073 0.0 pyk 2.7.1.40, 2.7.7.4 G Belongs to the pyruvate kinase family
HPPHLOHB_03074 3.4e-180 pfkA 2.7.1.11 F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
HPPHLOHB_03075 4.3e-183 accA 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
HPPHLOHB_03076 8.4e-162 accD 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPPHLOHB_03077 1.5e-225 ytsJ 1.1.1.38 C Malate dehydrogenase
HPPHLOHB_03078 0.0 dnaE 2.7.7.7 L DNA polymerase
HPPHLOHB_03079 3.2e-56 ytrH S Sporulation protein YtrH
HPPHLOHB_03080 8.2e-69 ytrI
HPPHLOHB_03081 9.2e-29
HPPHLOHB_03082 7.8e-182 nrnA 3.1.13.3, 3.1.3.7 S COG0618 Exopolyphosphatase-related proteins
HPPHLOHB_03083 2.4e-47 ytpI S YtpI-like protein
HPPHLOHB_03084 8e-241 ytoI K transcriptional regulator containing CBS domains
HPPHLOHB_03085 1.2e-158 ytnM S membrane transporter protein
HPPHLOHB_03086 4.9e-240 ytnL 3.5.1.47 E hydrolase activity
HPPHLOHB_03087 6.3e-128 ribF 2.7.1.26, 2.7.7.2 H Riboflavin kinase
HPPHLOHB_03088 1e-256 moxC C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPPHLOHB_03089 2.9e-47 ytnI O COG0695 Glutaredoxin and related proteins
HPPHLOHB_03090 1.2e-185 ytmO C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPPHLOHB_03091 1e-142 tcyN 3.6.3.21 E COG1126 ABC-type polar amino acid transport system, ATPase component
HPPHLOHB_03092 7.6e-121 tcyM U Binding-protein-dependent transport system inner membrane component
HPPHLOHB_03093 3.7e-123 tcyL P Binding-protein-dependent transport system inner membrane component
HPPHLOHB_03094 1.5e-149 tcyK M Bacterial periplasmic substrate-binding proteins
HPPHLOHB_03095 9.5e-152 tcyK ET Bacterial periplasmic substrate-binding proteins
HPPHLOHB_03096 1.5e-100 ytmI K Acetyltransferase (GNAT) domain
HPPHLOHB_03097 2.9e-173 ytlI K LysR substrate binding domain
HPPHLOHB_03098 1.7e-130 ytkL S Belongs to the UPF0173 family
HPPHLOHB_03099 1.1e-141 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HPPHLOHB_03101 3.1e-267 argH 4.3.2.1 E argininosuccinate lyase
HPPHLOHB_03102 2.3e-234 argG 6.3.4.5 E Belongs to the argininosuccinate synthase family. Type 1 subfamily
HPPHLOHB_03103 3.6e-88 moaB 2.7.7.75 H May be involved in the biosynthesis of molybdopterin
HPPHLOHB_03104 3.7e-221 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPPHLOHB_03105 7e-165 ytxK 2.1.1.72 L DNA methylase
HPPHLOHB_03106 2.4e-89 tpx 1.11.1.15 O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HPPHLOHB_03107 8.7e-70 ytfJ S Sporulation protein YtfJ
HPPHLOHB_03108 5.6e-116 ytfI S Protein of unknown function (DUF2953)
HPPHLOHB_03109 1.3e-87 yteJ S RDD family
HPPHLOHB_03110 2.4e-181 sppA OU signal peptide peptidase SppA
HPPHLOHB_03111 2.2e-148 nadK 2.7.1.23 G Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HPPHLOHB_03112 0.0 ytcJ S amidohydrolase
HPPHLOHB_03113 2e-307 acsA 6.2.1.1, 6.2.1.2 I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases
HPPHLOHB_03114 2e-29 sspB S spore protein
HPPHLOHB_03115 3.5e-227 thiI 2.8.1.4 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPPHLOHB_03116 2.2e-210 iscS2 2.8.1.7 E Cysteine desulfurase
HPPHLOHB_03117 4.9e-238 brnQ E Component of the transport system for branched-chain amino acids
HPPHLOHB_03118 4.1e-274 ezrA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HPPHLOHB_03119 1.6e-154 hisK 3.1.3.15 E COG1387 Histidinol phosphatase and related hydrolases of the PHP family
HPPHLOHB_03120 3.4e-109 yttP K Transcriptional regulator
HPPHLOHB_03121 1.2e-88 ytsP 1.8.4.14 T GAF domain-containing protein
HPPHLOHB_03122 0.0 ytrP 2.7.7.65 T COG2199 FOG GGDEF domain
HPPHLOHB_03123 2.5e-109 rpsD J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPPHLOHB_03125 3.6e-238 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPPHLOHB_03126 0.0 acsA 6.2.1.1 I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases
HPPHLOHB_03127 3.6e-122 acuA K Part of the acuABC operon, which is possibly involved in the breakdown of acetoin and butanediol. Acts as an acetyltransferase inactivating acetyl-CoA synthetase AcsA via acetylation at a Lys residue
HPPHLOHB_03128 1.6e-117 acuB S Domain in cystathionine beta-synthase and other proteins.
HPPHLOHB_03129 1.9e-225 acuC BQ histone deacetylase
HPPHLOHB_03130 1.4e-125 motS N Flagellar motor protein
HPPHLOHB_03131 7.1e-147 motA N flagellar motor
HPPHLOHB_03132 1.7e-182 ccpA K catabolite control protein A
HPPHLOHB_03133 4.9e-196 aroF 2.5.1.54, 5.4.99.5 E Catalyzes the formation of 3-deoxy-D-aribino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate and the formation of prephenate from chorismate
HPPHLOHB_03134 4.4e-55 ytxJ O Protein of unknown function (DUF2847)
HPPHLOHB_03135 6.6e-17 ytxH S COG4980 Gas vesicle protein
HPPHLOHB_03136 2.1e-17 ytxG S protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HPPHLOHB_03137 1.6e-254 mpl 6.3.2.4, 6.3.2.45, 6.3.2.8 M Belongs to the MurCDEF family
HPPHLOHB_03138 0.0 sftA D Belongs to the FtsK SpoIIIE SftA family
HPPHLOHB_03139 9.7e-109 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HPPHLOHB_03140 9.8e-149 ytpQ S Belongs to the UPF0354 family
HPPHLOHB_03141 2.1e-57 ytpP 2.7.1.180, 5.3.4.1 CO Thioredoxin
HPPHLOHB_03142 5.9e-79 ytoQ S Nucleoside 2-deoxyribosyltransferase YtoQ
HPPHLOHB_03143 4.7e-207 pepA 3.4.11.7 G COG1363 Cellulase M and related proteins
HPPHLOHB_03144 9.8e-52 ytzB S small secreted protein
HPPHLOHB_03145 0.0 sfcA 1.1.1.38 C Malate dehydrogenase
HPPHLOHB_03146 6.4e-151 ytnP S COG0491 Zn-dependent hydrolases, including glyoxylases
HPPHLOHB_03147 1.4e-121 trmB 2.1.1.297, 2.1.1.33 J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
HPPHLOHB_03148 2e-45 ytzH S YtzH-like protein
HPPHLOHB_03149 6.1e-151 ytmP 2.7.1.89 M Phosphotransferase
HPPHLOHB_03150 0.0 pulA 3.2.1.41 CBM48,GH13 G Belongs to the glycosyl hydrolase 13 family
HPPHLOHB_03151 2.9e-181 ytlR 2.7.1.91 I Diacylglycerol kinase catalytic domain
HPPHLOHB_03152 1.3e-165 ytlQ
HPPHLOHB_03153 4.3e-103 ligT 3.1.4.58, 3.5.1.42 J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HPPHLOHB_03154 8.6e-173 ytkP 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
HPPHLOHB_03155 7.1e-272 pepV 3.5.1.18 E Dipeptidase
HPPHLOHB_03156 7.2e-226 pbuO S permease
HPPHLOHB_03157 3.9e-207 ythQ U Bacterial ABC transporter protein EcsB
HPPHLOHB_03158 4.3e-132 ythP V ABC transporter
HPPHLOHB_03159 2.4e-33 ytzE K COG1349 Transcriptional regulators of sugar metabolism
HPPHLOHB_03160 2.6e-132 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
HPPHLOHB_03161 1.9e-281 ytgP S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
HPPHLOHB_03162 8.2e-232 ytfP S HI0933-like protein
HPPHLOHB_03163 3.4e-283 opuD M Belongs to the BCCT transporter (TC 2.A.15) family
HPPHLOHB_03164 3.1e-26 yteV S Sporulation protein Cse60
HPPHLOHB_03165 4.8e-117 yteU S Integral membrane protein
HPPHLOHB_03166 9.2e-258 yteT S Oxidoreductase family, C-terminal alpha/beta domain
HPPHLOHB_03167 4.6e-73 yteS G transport
HPPHLOHB_03168 4.7e-226 yteR 3.2.1.172 GH105 G unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins
HPPHLOHB_03169 2e-172 lplB G COG4209 ABC-type polysaccharide transport system, permease component
HPPHLOHB_03170 0.0 ytdP K Transcriptional regulator
HPPHLOHB_03171 1.2e-290 ytcQ G COG1653 ABC-type sugar transport system, periplasmic component
HPPHLOHB_03172 1.5e-150 ytcP G COG0395 ABC-type sugar transport system, permease component
HPPHLOHB_03173 9.6e-138 udh 1.1.1.203, 1.1.1.388 GM NAD dependent epimerase/dehydratase family
HPPHLOHB_03174 1.9e-225 bioI 1.14.14.46 C Cytochrome P450
HPPHLOHB_03175 2.2e-190 bioB 2.8.1.6 H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPPHLOHB_03176 3.7e-128 bioD 6.3.3.3 H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPPHLOHB_03177 1.4e-220 bioF 2.3.1.29, 2.3.1.47, 6.2.1.14 H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide
HPPHLOHB_03178 2.4e-261 bioA 2.6.1.105, 2.6.1.62 H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor
HPPHLOHB_03179 1.6e-142 bioW 2.3.1.47, 6.2.1.14 H Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
HPPHLOHB_03180 1.3e-173 ytaP S Acetyl xylan esterase (AXE1)
HPPHLOHB_03181 2.3e-190 msmR K Transcriptional regulator
HPPHLOHB_03182 2.3e-248 msmE G Bacterial extracellular solute-binding protein
HPPHLOHB_03183 3.7e-168 amyD P ABC transporter
HPPHLOHB_03184 1.5e-144 amyC P ABC transporter (permease)
HPPHLOHB_03185 4e-253 melA 3.2.1.122, 3.2.1.22, 3.2.1.86 GH4,GT4 G Family 4 glycosyl hydrolase
HPPHLOHB_03186 2.1e-51 ytwF P Sulfurtransferase
HPPHLOHB_03187 0.0 leuS 6.1.1.4 J Belongs to the class-I aminoacyl-tRNA synthetase family
HPPHLOHB_03188 7.7e-55 ytvB S Protein of unknown function (DUF4257)
HPPHLOHB_03189 6e-143 pfyP T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)
HPPHLOHB_03190 2.1e-211 yttB EGP Major facilitator Superfamily
HPPHLOHB_03191 1.8e-43 yttA 2.7.13.3 S Pfam Transposase IS66
HPPHLOHB_03192 0.0 bceB V ABC transporter (permease)
HPPHLOHB_03193 1.1e-138 bceA V ABC transporter, ATP-binding protein
HPPHLOHB_03194 5.6e-186 T PhoQ Sensor
HPPHLOHB_03195 5.2e-130 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HPPHLOHB_03196 8.5e-235 ytrF V COG0577 ABC-type antimicrobial peptide transport system, permease component
HPPHLOHB_03197 3.1e-127 ytrE V ABC transporter, ATP-binding protein
HPPHLOHB_03198 5.9e-148
HPPHLOHB_03199 6.1e-169 P ABC-2 family transporter protein
HPPHLOHB_03200 1.1e-161 ytrB P abc transporter atp-binding protein
HPPHLOHB_03201 5.1e-66 ytrA K GntR family transcriptional regulator
HPPHLOHB_03203 6.7e-41 ytzC S Protein of unknown function (DUF2524)
HPPHLOHB_03204 2.1e-190 yhcC S Fe-S oxidoreductase
HPPHLOHB_03205 3.3e-106 ytqB J Putative rRNA methylase
HPPHLOHB_03206 5.7e-216 ytpB 4.2.3.130 S Tetraprenyl-beta-curcumene synthase
HPPHLOHB_03207 3.3e-149 ytpA 3.1.1.5 I Alpha beta hydrolase
HPPHLOHB_03208 1.6e-59 ytoA S COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPPHLOHB_03209 8.4e-257 ytnA E COG1113 Gamma-aminobutyrate permease and related permeases
HPPHLOHB_03210 0.0 asnB 6.3.5.4 E Asparagine synthase
HPPHLOHB_03211 4.3e-225 metK 2.5.1.6 H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HPPHLOHB_03212 2.2e-311 pckA 4.1.1.49 C Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HPPHLOHB_03213 1.2e-38 ytmB S Protein of unknown function (DUF2584)
HPPHLOHB_03214 5.5e-149 ytmA E COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases
HPPHLOHB_03215 5e-190 ytlA P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components
HPPHLOHB_03216 1.4e-144 ytlC P ABC transporter
HPPHLOHB_03217 1.8e-142 ytlD P COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component
HPPHLOHB_03218 2.8e-87 ytkD 3.6.1.55 L Belongs to the Nudix hydrolase family
HPPHLOHB_03219 5.4e-63 ytkC S Bacteriophage holin family
HPPHLOHB_03220 2.1e-76 dps P Belongs to the Dps family
HPPHLOHB_03222 3.6e-73 ytkA S YtkA-like
HPPHLOHB_03223 1.6e-87 luxS 4.4.1.21 T Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
HPPHLOHB_03224 5.7e-103 ytiB 4.2.1.1 P Reversible hydration of carbon dioxide
HPPHLOHB_03225 3.6e-41 rpmE2 J Ribosomal protein L31
HPPHLOHB_03226 4.7e-249 cydA 1.10.3.14 C oxidase, subunit
HPPHLOHB_03227 7.3e-189 cydB 1.10.3.14 C COG1294 Cytochrome bd-type quinol oxidase, subunit 2
HPPHLOHB_03228 1.1e-24 S Domain of Unknown Function (DUF1540)
HPPHLOHB_03229 1.4e-151 troD P 'COG1108 ABC-type Mn2 Zn2 transport systems, permease components'
HPPHLOHB_03230 3.2e-234 mntC P COG1108 ABC-type Mn2 Zn2 transport systems, permease components
HPPHLOHB_03231 1.2e-140 mntB P 'COG1121 ABC-type Mn Zn transport systems, ATPase component'
HPPHLOHB_03232 1.8e-170 troA P Belongs to the bacterial solute-binding protein 9 family
HPPHLOHB_03233 1.4e-214 menC 4.2.1.113 H Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)
HPPHLOHB_03234 2.4e-278 menE 6.2.1.26 H Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily
HPPHLOHB_03235 4.2e-155 menB 4.1.3.36 H Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HPPHLOHB_03236 3.8e-156 menH 4.2.99.20 S Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC)
HPPHLOHB_03237 0.0 menD 2.2.1.9 H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HPPHLOHB_03238 8.5e-273 menF 5.4.4.2 HQ Isochorismate synthase
HPPHLOHB_03239 2.6e-132 dksA T COG1734 DnaK suppressor protein
HPPHLOHB_03240 1e-153 galU 2.7.7.9 M Nucleotidyl transferase
HPPHLOHB_03241 1.5e-244 ugd 1.1.1.22 M Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HPPHLOHB_03242 3.9e-181 ytcB 5.1.3.2 M NAD-dependent epimerase dehydratase
HPPHLOHB_03243 3.6e-235 ytcC M Glycosyltransferase Family 4
HPPHLOHB_03245 2.3e-206 cotS S Seems to be required for the assembly of the CotSA protein in spores
HPPHLOHB_03246 1.8e-217 cotSA M Glycosyl transferases group 1
HPPHLOHB_03247 1.8e-206 cotI S Spore coat protein
HPPHLOHB_03248 9.9e-77 tspO T membrane
HPPHLOHB_03249 0.0 glgP 2.4.1.1 GT35 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
HPPHLOHB_03250 4.3e-288 glgA 2.4.1.21 GT5 G Synthesizes alpha-1,4-glucan chains using ADP-glucose
HPPHLOHB_03251 1.3e-177 glgD 2.4.1.21, 2.7.7.27 GT5 G Glucose-1-phosphate adenylyltransferase, GlgD subunit
HPPHLOHB_03252 3.6e-197 glgC 2.7.7.27 G Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPPHLOHB_03253 0.0 glgB 2.4.1.18, 3.2.1.141, 3.2.1.20 CBM48,GH13,GH31 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HPPHLOHB_03262 7.8e-08
HPPHLOHB_03263 1.3e-09
HPPHLOHB_03270 2e-08
HPPHLOHB_03275 3.4e-39 S COG NOG14552 non supervised orthologous group
HPPHLOHB_03276 4.3e-90 thiT S Thiamine transporter protein (Thia_YuaJ)
HPPHLOHB_03277 3.4e-94 M1-753 M FR47-like protein
HPPHLOHB_03278 4.1e-188 yuaG 3.4.21.72 S protein conserved in bacteria
HPPHLOHB_03279 1.4e-77 yuaF OU Membrane protein implicated in regulation of membrane protease activity
HPPHLOHB_03280 3.9e-84 yuaE S DinB superfamily
HPPHLOHB_03281 7.9e-108 yuaD
HPPHLOHB_03282 2.9e-229 gbsB 1.1.1.1 C alcohol dehydrogenase
HPPHLOHB_03283 8e-282 gbsA 1.2.1.8 C Belongs to the aldehyde dehydrogenase family
HPPHLOHB_03284 1.1e-95 yuaC K Belongs to the GbsR family
HPPHLOHB_03285 2.2e-91 yuaB
HPPHLOHB_03286 5e-122 ktrA P COG0569 K transport systems, NAD-binding component
HPPHLOHB_03287 5.4e-237 ktrB P Potassium
HPPHLOHB_03288 1e-38 yiaA S yiaA/B two helix domain
HPPHLOHB_03289 6.4e-153 NU Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
HPPHLOHB_03290 6.2e-277 yubD P Major Facilitator Superfamily
HPPHLOHB_03291 2.6e-88 cdoA 1.13.11.20 S Cysteine dioxygenase type I
HPPHLOHB_03293 1.2e-133 uppP 3.6.1.27 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
HPPHLOHB_03294 6.3e-197 yubA S transporter activity
HPPHLOHB_03295 3.3e-183 ygjR S Oxidoreductase
HPPHLOHB_03296 1.4e-253 rhaA 2.7.1.5, 5.3.1.14 G Belongs to the rhamnose isomerase family
HPPHLOHB_03297 2.5e-55 rhaM 5.1.3.32 G Involved in the anomeric conversion of L-rhamnose
HPPHLOHB_03298 1.3e-281 rhaB 2.7.1.12, 2.7.1.17, 2.7.1.5, 5.3.1.14 G Involved in the catabolism of L-rhamnose (6-deoxy-L- mannose). Catalyzes the transfer of the gamma-phosphate group from ATP to the 1-hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate
HPPHLOHB_03299 1e-134 fucR K COG1349 Transcriptional regulators of sugar metabolism
HPPHLOHB_03300 0.0 rhaD 1.1.1.1, 4.1.2.19 IQ Class II Aldolase and Adducin N-terminal domain
HPPHLOHB_03301 5.1e-239 mcpA NT chemotaxis protein
HPPHLOHB_03302 2.2e-295 mcpA NT chemotaxis protein
HPPHLOHB_03303 1.5e-222 mcpA NT chemotaxis protein
HPPHLOHB_03304 3.2e-225 mcpA NT chemotaxis protein
HPPHLOHB_03305 2.6e-140 tgl 2.3.2.13 S protein-glutamine gamma-glutamyltransferase activity
HPPHLOHB_03306 1e-35
HPPHLOHB_03307 2.1e-72 yugU S Uncharacterised protein family UPF0047
HPPHLOHB_03308 0.0 yugT 3.2.1.10, 3.2.1.20 GH13,GH31 G COG0366 Glycosidases
HPPHLOHB_03309 2.6e-236 yugS S COG1253 Hemolysins and related proteins containing CBS domains
HPPHLOHB_03310 1.4e-116 yugP S Zn-dependent protease
HPPHLOHB_03311 4.6e-39
HPPHLOHB_03312 1.1e-53 mstX S Membrane-integrating protein Mistic
HPPHLOHB_03313 1.7e-182 yugO P COG1226 Kef-type K transport systems
HPPHLOHB_03314 1.3e-72 yugN S YugN-like family
HPPHLOHB_03316 4.2e-261 pgi 5.3.1.9 G Belongs to the GPI family
HPPHLOHB_03317 2.8e-229 yugK C Dehydrogenase
HPPHLOHB_03318 8.9e-228 yugJ C oxidoreductases, Fe-dependent alcohol dehydrogenase family
HPPHLOHB_03319 1.1e-34 yuzA S Domain of unknown function (DUF378)
HPPHLOHB_03320 8.9e-63 yugI 5.3.1.9 J RNA binding protein (contains ribosomal protein S1 domain)
HPPHLOHB_03321 4.3e-200 yugH 2.6.1.1 E Aminotransferase
HPPHLOHB_03322 1.6e-85 alaR K Transcriptional regulator
HPPHLOHB_03323 1e-156 yugF I Hydrolase
HPPHLOHB_03324 9.8e-42 yugE S Domain of unknown function (DUF1871)
HPPHLOHB_03325 1.8e-228 patB 4.4.1.8 E COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
HPPHLOHB_03326 4.6e-233 T PhoQ Sensor
HPPHLOHB_03327 2e-70 kapB G Kinase associated protein B
HPPHLOHB_03328 1.9e-115 kapD L the KinA pathway to sporulation
HPPHLOHB_03330 3.5e-186 yuxJ EGP Major facilitator Superfamily
HPPHLOHB_03331 0.0 mrcB 2.4.1.129, 3.4.16.4 GT51 M Penicillin-binding Protein
HPPHLOHB_03332 6.3e-75 yuxK S protein conserved in bacteria
HPPHLOHB_03333 6.3e-78 yufK S Family of unknown function (DUF5366)
HPPHLOHB_03334 9.9e-294 dcuS 2.7.13.3 T Signal transduction histidine kinase regulating citrate malate metabolism
HPPHLOHB_03335 2.3e-125 dcuR T COG4565 Response regulator of citrate malate metabolism
HPPHLOHB_03336 3.4e-197 tcsA S ABC-type transport system, periplasmic component surface lipoprotein
HPPHLOHB_03337 1.1e-273 xylG 3.6.3.17 S ABC transporter, ATP-binding protein
HPPHLOHB_03338 6.5e-185 yufP S Belongs to the binding-protein-dependent transport system permease family
HPPHLOHB_03339 4.5e-169 yufQ S Belongs to the binding-protein-dependent transport system permease family
HPPHLOHB_03340 1.3e-233 maeN C COG3493 Na citrate symporter
HPPHLOHB_03341 1.9e-14
HPPHLOHB_03342 0.0 phaA 1.6.5.3 CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit
HPPHLOHB_03343 5.4e-69 mrpB P Subunit B of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
HPPHLOHB_03344 1.5e-50 phaC 1.6.5.3 P Subunit C of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
HPPHLOHB_03345 3.8e-263 mrpD CP Subunit D of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
HPPHLOHB_03346 4.8e-79 mrpE P Subunit E of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
HPPHLOHB_03347 7.2e-38 phaF P Subunit F of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
HPPHLOHB_03348 5.2e-60 phaG P COG1320 Multisubunit Na H antiporter, MnhG subunit
HPPHLOHB_03349 9.2e-65 ydiI Q protein, possibly involved in aromatic compounds catabolism
HPPHLOHB_03350 5.1e-116 comA K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HPPHLOHB_03351 8.2e-221 comP 2.7.13.3 T Histidine kinase
HPPHLOHB_03352 1.9e-193 comP 2.7.13.3 T Histidine kinase
HPPHLOHB_03354 2.5e-162 comQ H Polyprenyl synthetase
HPPHLOHB_03356 1.1e-22 yuzC
HPPHLOHB_03357 2.2e-232 yuxH 3.1.4.52 T signal transduction protein containing EAL and modified HD-GYP domains
HPPHLOHB_03358 3.6e-266 pncB 6.3.4.21 H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPPHLOHB_03359 2.9e-104 pncA Q COG1335 Amidases related to nicotinamidase
HPPHLOHB_03360 1.6e-67 yueI S Protein of unknown function (DUF1694)
HPPHLOHB_03361 7.4e-39 yueH S YueH-like protein
HPPHLOHB_03362 2.1e-32 yueG S Spore germination protein gerPA/gerPF
HPPHLOHB_03363 1.9e-190 yueF S transporter activity
HPPHLOHB_03364 6.1e-72 S Protein of unknown function (DUF2283)
HPPHLOHB_03365 2.9e-24 S Protein of unknown function (DUF2642)
HPPHLOHB_03366 4.8e-96 yueE S phosphohydrolase
HPPHLOHB_03367 4.4e-132 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HPPHLOHB_03368 6.6e-65 yueC S Family of unknown function (DUF5383)
HPPHLOHB_03369 0.0 esaA S type VII secretion protein EsaA
HPPHLOHB_03370 0.0 essC D COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins
HPPHLOHB_03371 2.3e-211 essB S WXG100 protein secretion system (Wss), protein YukC
HPPHLOHB_03372 7.7e-41 yukD S WXG100 protein secretion system (Wss), protein YukD
HPPHLOHB_03373 2.8e-45 esxA S Belongs to the WXG100 family
HPPHLOHB_03374 6.5e-229 yukF QT Transcriptional regulator
HPPHLOHB_03375 1.2e-205 ald 1.4.1.1 E Belongs to the AlaDH PNT family
HPPHLOHB_03376 1.1e-132 yukJ S Uncharacterized conserved protein (DUF2278)
HPPHLOHB_03377 3.8e-36 mbtH S MbtH-like protein
HPPHLOHB_03378 0.0 dhbF Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HPPHLOHB_03379 1.4e-178 entB 3.3.2.1, 6.3.2.14 Q Isochorismatase family
HPPHLOHB_03380 0.0 entE 2.7.7.58, 6.3.2.14 Q 2,3-dihydroxybenzoate-AMP ligase
HPPHLOHB_03381 2.3e-226 entC 5.4.4.2 HQ Isochorismate synthase
HPPHLOHB_03382 7.3e-141 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
HPPHLOHB_03383 1.3e-167 besA S Putative esterase
HPPHLOHB_03384 5.8e-122 yuiH S Oxidoreductase molybdopterin binding domain
HPPHLOHB_03385 1.1e-93 bioY S Biotin biosynthesis protein
HPPHLOHB_03386 3.9e-211 yuiF S antiporter
HPPHLOHB_03387 1.5e-280 pepA 3.4.11.1, 3.4.11.5 E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPPHLOHB_03388 1.2e-77 yuiD S protein conserved in bacteria
HPPHLOHB_03389 9.5e-118 yuiC S protein conserved in bacteria
HPPHLOHB_03390 8.4e-27 yuiB S Putative membrane protein
HPPHLOHB_03391 2.5e-236 yumB 1.6.99.3 C NADH dehydrogenase
HPPHLOHB_03392 3.5e-188 yumC 1.18.1.2, 1.19.1.1 C reductase
HPPHLOHB_03394 4.9e-187 guaC 1.1.1.205, 1.7.1.7 F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
HPPHLOHB_03395 9e-118 paiB K Putative FMN-binding domain
HPPHLOHB_03396 4.7e-72 paiA 2.3.1.57 K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HPPHLOHB_03397 3.7e-63 erpA S Belongs to the HesB IscA family
HPPHLOHB_03398 2.2e-162 dapF 5.1.1.7 E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HPPHLOHB_03399 2.4e-199 yutK F Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPPHLOHB_03400 3.2e-39 yuzB S Belongs to the UPF0349 family
HPPHLOHB_03401 1.2e-199 yutJ 1.6.99.3 C NADH dehydrogenase
HPPHLOHB_03402 3.5e-57 yuzD S protein conserved in bacteria
HPPHLOHB_03403 1.2e-35 yutI O COG0694 Thioredoxin-like proteins and domains
HPPHLOHB_03404 0.0 yuxL 3.4.14.5, 3.4.19.1 EU peptidase
HPPHLOHB_03405 8.6e-173 thrB 2.7.1.39 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
HPPHLOHB_03406 2.3e-198 thrC 4.2.3.1 E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HPPHLOHB_03407 2.7e-241 hom 1.1.1.3 E homoserine dehydrogenase
HPPHLOHB_03408 2e-199 yutH S Spore coat protein
HPPHLOHB_03409 2.5e-77 pgpA 3.1.3.27 I COG1267 Phosphatidylglycerophosphatase A and related proteins
HPPHLOHB_03410 6.5e-142 nagD 2.7.1.25, 3.1.3.41 G Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
HPPHLOHB_03411 1e-75 yutE S Protein of unknown function DUF86
HPPHLOHB_03412 9.7e-48 yutD S protein conserved in bacteria
HPPHLOHB_03413 4.9e-111 yutC S Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
HPPHLOHB_03414 1e-167 lipA 2.8.1.8 H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HPPHLOHB_03415 4.5e-196 lytH M Peptidase, M23
HPPHLOHB_03416 8.4e-134 yunB S Sporulation protein YunB (Spo_YunB)
HPPHLOHB_03417 4.8e-48 yunC S Domain of unknown function (DUF1805)
HPPHLOHB_03418 5.8e-266 yunD 3.1.3.5 F Belongs to the 5'-nucleotidase family
HPPHLOHB_03419 2e-141 yunE S membrane transporter protein
HPPHLOHB_03420 4.3e-171 yunF S Protein of unknown function DUF72
HPPHLOHB_03421 3e-62 yunG
HPPHLOHB_03422 1e-259 allB 3.5.2.5 F Catalyzes the conversion of allantoin (5- ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring
HPPHLOHB_03423 1.2e-302 pucR QT COG2508 Regulator of polyketide synthase expression
HPPHLOHB_03424 2.1e-236 pbuX F Permease family
HPPHLOHB_03425 1.3e-224 pbuX F xanthine
HPPHLOHB_03426 6.6e-284 uraD 1.7.3.3, 3.5.1.41, 4.1.1.97 Q Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin
HPPHLOHB_03427 7.3e-61 uraH 3.5.2.17, 4.1.1.97 S Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily
HPPHLOHB_03428 7.9e-99 1.17.1.4, 1.2.5.3, 1.3.99.16 C COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs
HPPHLOHB_03429 0.0 xdhA 1.17.1.4 C COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs
HPPHLOHB_03430 3.4e-152 ygfM 1.17.1.4, 1.2.5.3 C COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM CutM homologs
HPPHLOHB_03431 3.6e-111 pucB 1.1.1.328, 1.17.1.4, 2.7.7.76 S MobA-like NTP transferase domain
HPPHLOHB_03432 1.7e-190 pucA 1.17.1.4 O COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HPPHLOHB_03434 1.9e-239 pucG 2.6.1.112, 2.6.1.44, 2.6.1.45, 2.6.1.51 E COG0075 Serine-pyruvate aminotransferase archaeal aspartate aminotransferase
HPPHLOHB_03435 1.6e-238 pucF 3.5.1.6, 3.5.1.87, 3.5.3.9 E COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases
HPPHLOHB_03436 2.4e-169 bsn L Ribonuclease
HPPHLOHB_03437 1.2e-205 msmX P Belongs to the ABC transporter superfamily
HPPHLOHB_03438 1.1e-135 yurK K UTRA
HPPHLOHB_03439 1.5e-163 yurL 2.7.1.218 G pfkB family carbohydrate kinase
HPPHLOHB_03440 7.3e-169 yurM P COG0395 ABC-type sugar transport system, permease component
HPPHLOHB_03441 1.4e-156 yurN G Binding-protein-dependent transport system inner membrane component
HPPHLOHB_03442 1.3e-240 yurO G COG1653 ABC-type sugar transport system, periplasmic component
HPPHLOHB_03443 1.8e-184 frlB M Catalyzes the conversion of a range of fructosamine 6- phosphates to glucose 6-phosphate and a free amino acid
HPPHLOHB_03444 2.8e-66 yurQ 2.7.7.7 L COG0322 Nuclease subunit of the excinuclease complex
HPPHLOHB_03445 1.8e-209 yurR 1.4.5.1 E COG0665 Glycine D-amino acid oxidases (deaminating)
HPPHLOHB_03447 1e-41
HPPHLOHB_03448 7.6e-67 yurT E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HPPHLOHB_03449 3.5e-271 sufB O FeS cluster assembly
HPPHLOHB_03450 1.4e-77 nifU C COG0822 NifU homolog involved in Fe-S cluster formation
HPPHLOHB_03451 9.4e-236 sufS 2.8.1.7, 4.4.1.16 E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPPHLOHB_03452 1.4e-245 sufD O assembly protein SufD
HPPHLOHB_03453 2.3e-142 sufC O COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component
HPPHLOHB_03454 1.1e-62 yurZ 2.3.1.12, 4.1.1.44 S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPPHLOHB_03455 1.9e-147 metQ P Belongs to the NlpA lipoprotein family
HPPHLOHB_03456 1.4e-95 metI P COG2011 ABC-type metal ion transport system, permease component
HPPHLOHB_03457 4.8e-185 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPPHLOHB_03458 2.4e-56 yusD S SCP-2 sterol transfer family
HPPHLOHB_03459 5.6e-55 traF CO Thioredoxin
HPPHLOHB_03460 3.3e-74 rnmV 3.1.26.8 L COG1658 Small primase-like proteins (Toprim domain)
HPPHLOHB_03461 1.1e-39 yusG S Protein of unknown function (DUF2553)
HPPHLOHB_03462 9.3e-65 gcvH E Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate
HPPHLOHB_03463 2.8e-63 arsC 1.20.4.1 P Belongs to the ArsC family
HPPHLOHB_03464 0.0 fadE 1.3.8.1 I acyl-CoA dehydrogenase
HPPHLOHB_03465 1.4e-217 fadA 2.3.1.16 I Belongs to the thiolase family
HPPHLOHB_03466 0.0 fadB 1.1.1.35, 4.2.1.17, 5.1.2.3 I 3-hydroxyacyl-CoA dehydrogenase
HPPHLOHB_03467 4.7e-09 S YuzL-like protein
HPPHLOHB_03468 2.2e-165 fadM E Proline dehydrogenase
HPPHLOHB_03469 5.1e-40
HPPHLOHB_03470 3.2e-53 yusN M Coat F domain
HPPHLOHB_03471 5.4e-75 yusO K Iron dependent repressor, N-terminal DNA binding domain
HPPHLOHB_03472 3.8e-293 yusP P Major facilitator superfamily
HPPHLOHB_03473 8.4e-66 yusQ S Tautomerase enzyme
HPPHLOHB_03474 2.5e-62 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
HPPHLOHB_03475 2.5e-50 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
HPPHLOHB_03476 2.7e-160 yusT K LysR substrate binding domain
HPPHLOHB_03477 3.8e-47 yusU S Protein of unknown function (DUF2573)
HPPHLOHB_03478 1e-153 yusV 3.6.3.34 HP ABC transporter
HPPHLOHB_03479 5.6e-66 S YusW-like protein
HPPHLOHB_03480 6.3e-258 pepF2 E COG1164 Oligoendopeptidase F
HPPHLOHB_03481 3.9e-34 pepF2 E COG1164 Oligoendopeptidase F
HPPHLOHB_03482 4.7e-154 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
HPPHLOHB_03483 1.2e-79 dps P Ferritin-like domain
HPPHLOHB_03484 9.6e-237 htrA 3.4.21.107 O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPPHLOHB_03485 3.4e-126 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HPPHLOHB_03486 4.3e-250 cssS 2.7.13.3 T PhoQ Sensor
HPPHLOHB_03487 4.3e-158 yuxN K Transcriptional regulator
HPPHLOHB_03488 2.5e-261 fumC 1.1.1.38, 4.2.1.2 C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
HPPHLOHB_03489 2.3e-24 S Protein of unknown function (DUF3970)
HPPHLOHB_03490 2.2e-247 gerAA EG Spore germination protein
HPPHLOHB_03491 9.1e-198 gerAB E Spore germination protein
HPPHLOHB_03492 4.6e-189 gerAC S Spore germination B3/ GerAC like, C-terminal
HPPHLOHB_03493 1.3e-108 vraR KT COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HPPHLOHB_03494 5.5e-187 vraS 2.7.13.3 T Histidine kinase
HPPHLOHB_03495 5.6e-127 yvqF S Cell wall-active antibiotics response 4TMS YvqF
HPPHLOHB_03496 9.3e-129 liaG S Putative adhesin
HPPHLOHB_03497 2.5e-105 liaH KT COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription
HPPHLOHB_03498 5.6e-62 liaI S membrane
HPPHLOHB_03499 4.8e-227 yvqJ EGP Major facilitator Superfamily
HPPHLOHB_03500 6.5e-102 yvqK 2.5.1.17 S Adenosyltransferase
HPPHLOHB_03501 2.8e-249 yvrA 3.6.3.34 HP COG1120 ABC-type cobalamin Fe3 -siderophores transport systems, ATPase components
HPPHLOHB_03502 7.7e-186 btuC P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPPHLOHB_03503 1.8e-170 yvrC P COG0614 ABC-type Fe3 -hydroxamate transport system, periplasmic component
HPPHLOHB_03504 6.2e-140 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
HPPHLOHB_03505 1.5e-171 yvrE G SMP-30/Gluconolaconase/LRE-like region
HPPHLOHB_03506 0.0 T PhoQ Sensor
HPPHLOHB_03507 3.2e-131 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HPPHLOHB_03508 3.6e-22
HPPHLOHB_03509 1.8e-96 yvrI K RNA polymerase
HPPHLOHB_03510 2.4e-19 S YvrJ protein family
HPPHLOHB_03511 7.3e-230 oxdC 4.1.1.2 G Oxalate decarboxylase
HPPHLOHB_03512 1.3e-64 yvrL S Regulatory protein YrvL
HPPHLOHB_03513 1.8e-210 yvrN V COG0577 ABC-type antimicrobial peptide transport system, permease component
HPPHLOHB_03514 7.1e-124 macB V ABC transporter, ATP-binding protein
HPPHLOHB_03515 4.8e-176 M Efflux transporter rnd family, mfp subunit
HPPHLOHB_03516 4.4e-149 fhuC 3.6.3.34 HP ABC transporter
HPPHLOHB_03517 5.3e-176 fhuG P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPPHLOHB_03518 9.3e-184 fhuB P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPPHLOHB_03519 2.1e-179 fhuD P ABC transporter
HPPHLOHB_03521 2.6e-237 yvsH E Arginine ornithine antiporter
HPPHLOHB_03522 6.5e-16 S Small spore protein J (Spore_SspJ)
HPPHLOHB_03523 1e-84 yvsG S LexA-binding, inner membrane-associated putative hydrolase
HPPHLOHB_03524 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
HPPHLOHB_03525 8e-171 yvgK P COG1910 Periplasmic molybdate-binding protein domain
HPPHLOHB_03526 5.8e-138 modA P COG0725 ABC-type molybdate transport system, periplasmic component
HPPHLOHB_03527 4.7e-120 modB P COG4149 ABC-type molybdate transport system, permease component
HPPHLOHB_03528 9.1e-158 yvgN S reductase
HPPHLOHB_03529 5.4e-86 yvgO
HPPHLOHB_03530 0.0 yjcE P COG0025 NhaP-type Na H and K H antiporters
HPPHLOHB_03531 0.0 cysI 1.7.7.1, 1.8.1.2, 1.8.7.1 P Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate
HPPHLOHB_03532 0.0 cysJ 1.8.1.2 P Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPPHLOHB_03533 0.0 helD 3.6.4.12 L DNA helicase
HPPHLOHB_03534 4.1e-107 yvgT S membrane
HPPHLOHB_03535 2.2e-72 bdbC O Required for disulfide bond formation in some proteins
HPPHLOHB_03536 1.6e-104 bdbD O Thioredoxin
HPPHLOHB_03537 0.0 cadA 3.6.3.3, 3.6.3.5 P COG2217 Cation transport ATPase
HPPHLOHB_03538 0.0 copA 3.6.3.54 P P-type ATPase
HPPHLOHB_03539 1.5e-29 copZ P Copper resistance protein CopZ
HPPHLOHB_03540 2.2e-48 csoR S transcriptional
HPPHLOHB_03541 2.1e-199 yvaA 1.1.1.371 S Oxidoreductase
HPPHLOHB_03542 2.4e-118 azoR I Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HPPHLOHB_03543 0.0 yvaC S Fusaric acid resistance protein-like
HPPHLOHB_03544 5.7e-73 yvaD S Family of unknown function (DUF5360)
HPPHLOHB_03545 2.8e-55 yvaE P Small Multidrug Resistance protein
HPPHLOHB_03546 4.1e-101 K Bacterial regulatory proteins, tetR family
HPPHLOHB_03547 9.1e-131 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
HPPHLOHB_03549 1.6e-82 smpB O Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HPPHLOHB_03550 0.0 rnr K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
HPPHLOHB_03551 5.6e-143 est 3.1.1.1 S Carboxylesterase
HPPHLOHB_03552 2.4e-23 secG U Preprotein translocase subunit SecG
HPPHLOHB_03553 3.7e-153 yvaM S Serine aminopeptidase, S33
HPPHLOHB_03554 7.5e-36 yvzC K Transcriptional
HPPHLOHB_03555 4e-69 K transcriptional
HPPHLOHB_03556 8e-70 yvaO K Cro/C1-type HTH DNA-binding domain
HPPHLOHB_03557 2.2e-54 yodB K transcriptional
HPPHLOHB_03558 4.2e-226 NT chemotaxis protein
HPPHLOHB_03559 8.1e-112 opuCD P COG1174 ABC-type proline glycine betaine transport systems, permease component
HPPHLOHB_03560 1.1e-172 opuCC M COG1732 Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
HPPHLOHB_03561 2.5e-110 opuCB P COG1174 ABC-type proline glycine betaine transport systems, permease component
HPPHLOHB_03562 3e-212 opuCA 3.6.3.32 E COG1125 ABC-type proline glycine betaine transport systems, ATPase components
HPPHLOHB_03563 8.7e-61 yvbF K Belongs to the GbsR family
HPPHLOHB_03564 7.9e-13 S Sporulation delaying protein SdpA
HPPHLOHB_03565 7.6e-172
HPPHLOHB_03566 4.4e-08
HPPHLOHB_03567 3.3e-96 sdpI S Immunity protein that provides protection for the cell against the toxic effects of SDP, its own SdpC-derived killing factor, and that functions as a receptor signal transduction protein as well. Once SDP accumulates in the extracellular milieu, SdpI binds to SDP, causing sequestration of SdpR at the bacterial membrane
HPPHLOHB_03568 4.5e-45 sdpR K transcriptional
HPPHLOHB_03569 8.7e-114 opuCD P COG1174 ABC-type proline glycine betaine transport systems, permease component
HPPHLOHB_03570 2.5e-172 opuCC M COG1732 Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
HPPHLOHB_03571 4.5e-112 opuCB P COG1174 ABC-type proline glycine betaine transport systems, permease component
HPPHLOHB_03572 8.8e-212 opuCA 3.6.3.32 E COG1125 ABC-type proline glycine betaine transport systems, ATPase components
HPPHLOHB_03573 1.4e-98 yvbF K Belongs to the GbsR family
HPPHLOHB_03574 6.4e-103 yvbG U UPF0056 membrane protein
HPPHLOHB_03575 8.6e-113 yvbH S YvbH-like oligomerisation region
HPPHLOHB_03576 4.2e-124 exoY M Membrane
HPPHLOHB_03577 0.0 tcaA S response to antibiotic
HPPHLOHB_03578 7.7e-82 yvbK 3.1.3.25 K acetyltransferase
HPPHLOHB_03579 8.4e-243 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
HPPHLOHB_03580 1.3e-298 gpmI 5.4.2.12 G Catalyzes the interconversion of 2-phosphoglycerate and
HPPHLOHB_03581 4.3e-138 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
HPPHLOHB_03582 1e-218 pgk 2.7.2.3, 5.3.1.1 F Belongs to the phosphoglycerate kinase family
HPPHLOHB_03583 6.2e-185 gapA 1.2.1.12 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
HPPHLOHB_03584 6.3e-185 cggR K COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain
HPPHLOHB_03585 1.6e-252 araE EGP Major facilitator Superfamily
HPPHLOHB_03586 5.5e-203 araR K transcriptional
HPPHLOHB_03587 1.5e-191 yvbT C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPPHLOHB_03588 3.9e-159 yvbU K Transcriptional regulator
HPPHLOHB_03589 8.5e-157 yvbV EG EamA-like transporter family
HPPHLOHB_03590 2.8e-241 yvbW E COG1113 Gamma-aminobutyrate permease and related permeases
HPPHLOHB_03591 4.3e-197 yvbX S Glycosyl hydrolase
HPPHLOHB_03592 2.3e-133 lutC S Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source
HPPHLOHB_03593 1.2e-274 lutB C Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source. Has probably a role as an electron transporter during oxidation of L-lactate
HPPHLOHB_03594 1.5e-137 lutA C Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source
HPPHLOHB_03595 2.6e-106 desR T COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HPPHLOHB_03596 8.9e-201 desK 2.7.13.3 T Histidine kinase
HPPHLOHB_03597 6.2e-134 yvfS V COG0842 ABC-type multidrug transport system, permease component
HPPHLOHB_03598 3e-162 yvfR V COG1131 ABC-type multidrug transport system, ATPase component
HPPHLOHB_03599 2.6e-157 rsbQ S Alpha/beta hydrolase family
HPPHLOHB_03600 1.4e-199 rsbU 3.1.3.3 T response regulator
HPPHLOHB_03601 2.6e-252 galA 3.2.1.89 G arabinogalactan
HPPHLOHB_03602 0.0 lacA 3.2.1.23 G beta-galactosidase
HPPHLOHB_03603 3.2e-150 ganQ P transport
HPPHLOHB_03604 1.1e-231 malC P COG1175 ABC-type sugar transport systems, permease components
HPPHLOHB_03605 2.9e-232 cycB G COG2182 Maltose-binding periplasmic proteins domains
HPPHLOHB_03606 1.8e-184 lacR K Transcriptional regulator
HPPHLOHB_03607 6.6e-111 yvfI K COG2186 Transcriptional regulators
HPPHLOHB_03608 1.4e-309 yvfH C L-lactate permease
HPPHLOHB_03609 6.5e-243 rpoN K COG1508 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog
HPPHLOHB_03610 1e-31 yvfG S YvfG protein
HPPHLOHB_03611 5.8e-188 yvfF GM Exopolysaccharide biosynthesis protein
HPPHLOHB_03612 1.2e-224 epsN 2.6.1.102 E Belongs to the DegT DnrJ EryC1 family
HPPHLOHB_03613 2.2e-58 epsM GM COG0110 Acetyltransferase (isoleucine patch superfamily)
HPPHLOHB_03614 2.6e-109 epsL M COG2148 Sugar transferases involved in lipopolysaccharide synthesis
HPPHLOHB_03615 8.9e-260 pglK S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
HPPHLOHB_03616 1.9e-197 epsJ GT2 S COG0463 Glycosyltransferases involved in cell wall biogenesis
HPPHLOHB_03617 3.6e-207 epsI GM pyruvyl transferase
HPPHLOHB_03618 3.6e-196 epsH GT2 S Glycosyltransferase like family 2
HPPHLOHB_03619 4.8e-207 epsG S EpsG family
HPPHLOHB_03620 5.3e-220 epsF GT4 M Glycosyl transferases group 1
HPPHLOHB_03621 4.1e-158 epsE GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
HPPHLOHB_03622 2e-224 epsD GT4 M Glycosyl transferase 4-like
HPPHLOHB_03623 0.0 pglF 4.2.1.115, 4.2.1.135, 4.2.1.46 GM Polysaccharide biosynthesis protein
HPPHLOHB_03624 1e-114 epsB 2.7.10.2 D COG0489 ATPases involved in chromosome partitioning
HPPHLOHB_03625 4e-122 ywqC M biosynthesis protein
HPPHLOHB_03626 5.7e-77 slr K transcriptional
HPPHLOHB_03627 4.8e-287 pnbA CE10 I Belongs to the type-B carboxylesterase lipase family
HPPHLOHB_03629 4.6e-93 padC Q Phenolic acid decarboxylase
HPPHLOHB_03630 1.3e-48 MA20_18690 S Protein of unknown function (DUF3237)
HPPHLOHB_03631 3.1e-127 racX 5.1.1.13 M Belongs to the aspartate glutamate racemases family
HPPHLOHB_03632 9.6e-266 pbpE V Beta-lactamase
HPPHLOHB_03633 1.2e-274 sacB 2.4.1.10 GH68 M levansucrase activity
HPPHLOHB_03634 0.0 levB 3.2.1.26, 3.2.1.64, 3.2.1.65, 3.2.1.80 GH32 G Belongs to the glycosyl hydrolase 32 family
HPPHLOHB_03635 1.8e-295 yveA E amino acid
HPPHLOHB_03636 2.6e-106 yvdT K Transcriptional regulator
HPPHLOHB_03637 6.7e-51 ykkC P Small Multidrug Resistance protein
HPPHLOHB_03638 4.1e-50 sugE P Small Multidrug Resistance protein
HPPHLOHB_03639 2.2e-93 yvdQ S Protein of unknown function (DUF3231)
HPPHLOHB_03640 9.2e-269 ygaK C COG0277 FAD FMN-containing dehydrogenases
HPPHLOHB_03641 1.5e-183 S Patatin-like phospholipase
HPPHLOHB_03643 1.2e-103 clpP 3.4.21.92 OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
HPPHLOHB_03644 1.3e-122 pgmB 2.4.1.64, 3.1.3.12, 3.2.1.28, 5.4.2.6 GH37,GH65 S Haloacid dehalogenase-like hydrolase
HPPHLOHB_03645 0.0 malL 3.2.1.10 GH13 G COG0366 Glycosidases
HPPHLOHB_03646 0.0 yvdK 2.4.1.8 GH65 G Glycoside hydrolase, family 65
HPPHLOHB_03647 1.2e-158 malA S Protein of unknown function (DUF1189)
HPPHLOHB_03648 7.8e-149 malD P transport
HPPHLOHB_03649 5.3e-245 malC P COG1175 ABC-type sugar transport systems, permease components
HPPHLOHB_03650 1.3e-235 mdxE G COG2182 Maltose-binding periplasmic proteins domains
HPPHLOHB_03651 0.0 nplT 3.2.1.133, 3.2.1.135, 3.2.1.54 GH13 G Alpha amylase, N-terminal ig-like domain
HPPHLOHB_03652 3.6e-174 yvdE K Transcriptional regulator
HPPHLOHB_03653 3.3e-106 yvdD 3.2.2.10 S Belongs to the LOG family
HPPHLOHB_03654 6.8e-53 yvdC S MazG nucleotide pyrophosphohydrolase domain
HPPHLOHB_03655 2.1e-288 sulP P COG0659 Sulfate permease and related transporters (MFS superfamily)
HPPHLOHB_03656 5.7e-106 ytiB 4.2.1.1 P Reversible hydration of carbon dioxide
HPPHLOHB_03657 1.3e-184 ghrB 1.1.1.215, 1.1.1.26, 1.1.1.43, 1.1.1.79, 1.1.1.81 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPPHLOHB_03658 0.0 yxdM V ABC transporter (permease)
HPPHLOHB_03659 5.6e-141 yvcR V ABC transporter, ATP-binding protein
HPPHLOHB_03660 2.3e-198 yvcQ 2.7.13.3 T His Kinase A (phosphoacceptor) domain
HPPHLOHB_03661 3.9e-133 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HPPHLOHB_03662 1.8e-33
HPPHLOHB_03663 8.6e-147 nhoA 2.3.1.118 Q Belongs to the arylamine N-acetyltransferase family
HPPHLOHB_03664 1.6e-36 crh G Phosphocarrier protein Chr
HPPHLOHB_03665 1.4e-170 whiA K May be required for sporulation
HPPHLOHB_03666 7.3e-178 ybhK S Required for morphogenesis under gluconeogenic growth conditions
HPPHLOHB_03667 5.7e-166 rapZ S Displays ATPase and GTPase activities
HPPHLOHB_03668 1.8e-89 yvcI 3.6.1.55 F COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
HPPHLOHB_03669 1.4e-175 trxB 1.8.1.9 C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
HPPHLOHB_03670 1.4e-102 usp CBM50 M protein conserved in bacteria
HPPHLOHB_03671 2.4e-278 S COG0457 FOG TPR repeat
HPPHLOHB_03672 0.0 msbA2 3.6.3.44 V ABC transporter
HPPHLOHB_03674 0.0
HPPHLOHB_03675 4.6e-121
HPPHLOHB_03676 8e-114 hisE 3.5.4.19, 3.6.1.31, 5.3.1.16 E belongs to the PRA-CH family
HPPHLOHB_03677 2.8e-137 hisF E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
HPPHLOHB_03678 3.1e-133 hisA 5.3.1.16 E 1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPPHLOHB_03679 1.7e-116 hisH E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPPHLOHB_03680 2.1e-108 hisB 1.1.1.23, 2.6.1.9, 3.1.3.15, 4.2.1.19 E imidazoleglycerol-phosphate dehydratase
HPPHLOHB_03681 6.6e-232 hisD 1.1.1.23, 1.1.1.308 E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPPHLOHB_03682 1.5e-115 hisG 2.4.2.17 E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
HPPHLOHB_03683 4.8e-221 hisZ 2.4.2.17, 6.1.1.21 E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HPPHLOHB_03684 4.5e-140 yvpB NU protein conserved in bacteria
HPPHLOHB_03685 5.5e-121 hrpW 4.2.2.10, 4.2.2.2 G Pectate lyase
HPPHLOHB_03686 3e-82 yvoF S COG0110 Acetyltransferase (isoleucine patch superfamily)
HPPHLOHB_03687 1.3e-119 ppaX 3.1.3.18, 3.6.1.1 S Hydrolyzes pyrophosphate formed during P-Ser-HPr dephosphorylation by HPrK P. Might play a role in controlling the intracellular pyrophosphate pool
HPPHLOHB_03688 1.5e-164 yvoD P COG0370 Fe2 transport system protein B
HPPHLOHB_03689 4.9e-148 lgt 2.1.1.199 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HPPHLOHB_03690 1.7e-168 hprK F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HPPHLOHB_03691 6.8e-223 nagA 3.5.1.25 G Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPPHLOHB_03692 8.9e-133 nagB 3.1.1.31, 3.5.99.6 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
HPPHLOHB_03693 3.6e-134 yvoA K transcriptional
HPPHLOHB_03694 0.0 yvnB 3.1.4.53 Q Calcineurin-like phosphoesterase
HPPHLOHB_03695 8.5e-84 adcR K helix_turn_helix multiple antibiotic resistance protein
HPPHLOHB_03696 8.2e-232 cypX 1.14.15.13 C Cytochrome P450
HPPHLOHB_03697 1.6e-137 yvmC 2.3.2.22 S Involved in the biosynthesis of pulcherrimin, a red extracellular pigment. It uses activated amino acids in the form of aminoacyl-tRNAs (aa-tRNAs) as substrates to catalyze the ATP- independent formation of cyclodipeptides which are intermediates in diketopiperazine (DKP) biosynthetic pathways. Catalyzes the formation of cyclo(L-Leu-L-Leu) (cLL) from L-leucyl-tRNA(Leu). Can also incorporate various nonpolar residues, such as L- phenylalanine, L-leucine and methionine, into cyclodipeptides
HPPHLOHB_03698 3e-87 yvmB K helix_turn_helix multiple antibiotic resistance protein
HPPHLOHB_03699 2.7e-203 yvmA EGP Major facilitator Superfamily
HPPHLOHB_03700 1.2e-50 yvlD S Membrane
HPPHLOHB_03701 2.6e-26 pspB KT PspC domain
HPPHLOHB_03702 3.4e-168 yvlB S Putative adhesin
HPPHLOHB_03703 8e-49 yvlA
HPPHLOHB_03704 6.7e-34 yvkN
HPPHLOHB_03705 2.9e-79 fliC N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPPHLOHB_03706 0.0 uvrA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
HPPHLOHB_03707 0.0 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
HPPHLOHB_03708 1.2e-30 csbA S protein conserved in bacteria
HPPHLOHB_03709 0.0 yvkC 2.7.9.2 GT Phosphotransferase
HPPHLOHB_03710 7e-101 yvkB K Transcriptional regulator
HPPHLOHB_03711 7.9e-228 yvkA EGP Major facilitator Superfamily
HPPHLOHB_03712 4.9e-221 minJ O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPPHLOHB_03713 5.3e-56 swrA S Swarming motility protein
HPPHLOHB_03714 6.9e-270 ctpB 3.4.21.102 M Belongs to the peptidase S41A family
HPPHLOHB_03715 1.6e-155 ftsX D Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation
HPPHLOHB_03716 1.6e-123 ftsE D cell division ATP-binding protein FtsE
HPPHLOHB_03717 5.3e-56 cccB C COG2010 Cytochrome c, mono- and diheme variants
HPPHLOHB_03718 5.5e-142 yvjA S Uncharacterized protein conserved in bacteria (DUF2179)
HPPHLOHB_03719 6.1e-185 prfB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HPPHLOHB_03720 0.0 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
HPPHLOHB_03721 2.2e-102 hpf J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPPHLOHB_03722 2.8e-66
HPPHLOHB_03723 1.9e-08 fliT S bacterial-type flagellum organization
HPPHLOHB_03724 2.9e-69 fliS N flagellar protein FliS
HPPHLOHB_03725 1.3e-266 fliD N morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPPHLOHB_03726 6.1e-57 flaG N flagellar protein FlaG
HPPHLOHB_03727 1.9e-156 fliC N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPPHLOHB_03728 2e-30 csrA T Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HPPHLOHB_03729 2.7e-73 fliW S Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HPPHLOHB_03730 2.6e-50 yviE
HPPHLOHB_03731 1.1e-156 flgL N Belongs to the bacterial flagellin family
HPPHLOHB_03732 1.2e-264 flgK N flagellar hook-associated protein
HPPHLOHB_03733 2.4e-78 flgN NOU FlgN protein
HPPHLOHB_03734 7e-74 yvyF S flagellar protein
HPPHLOHB_03735 2.7e-129 comFC S Phosphoribosyl transferase domain
HPPHLOHB_03736 5.7e-46 comFB S Late competence development protein ComFB
HPPHLOHB_03737 5.6e-269 comFA L COG4098 Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HPPHLOHB_03738 7.3e-155 degV S protein conserved in bacteria
HPPHLOHB_03739 2e-126 degU KT COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HPPHLOHB_03740 5.1e-183 degS 2.7.13.3 T Member of the two-component regulatory system DegS DegU, which plays an important role in the transition growth phase
HPPHLOHB_03741 2e-120 yvyE 3.4.13.9 S Domain of unknown function (DUF1949)
HPPHLOHB_03742 6e-163 yvhJ K Transcriptional regulator
HPPHLOHB_03743 2.6e-181 tagO 2.7.8.33, 2.7.8.35 M COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase UDP-N-acetylglucosamine-1-phosphate transferase
HPPHLOHB_03744 4.4e-238 tuaH M Teichuronic acid biosynthesis glycosyltransferase tuaH
HPPHLOHB_03745 2.1e-145 tuaG GT2 M Glycosyltransferase like family 2
HPPHLOHB_03746 6e-115 tuaF M protein involved in exopolysaccharide biosynthesis
HPPHLOHB_03747 1.7e-263 tuaE M Teichuronic acid biosynthesis protein
HPPHLOHB_03748 2.4e-259 tuaD 1.1.1.22 M Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HPPHLOHB_03749 7.4e-222 tuaC 2.4.1.21, 3.2.1.1 GH13,GT4,GT5 GM Teichuronic acid
HPPHLOHB_03750 3.3e-248 wzxC S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
HPPHLOHB_03751 4.6e-112 tuaA M COG2148 Sugar transferases involved in lipopolysaccharide synthesis
HPPHLOHB_03752 3e-268 lytC 3.5.1.28 M n-acetylmuramoyl-L-alanine amidase
HPPHLOHB_03753 0.0 lytB 3.5.1.28 D Stage II sporulation protein
HPPHLOHB_03754 6e-38
HPPHLOHB_03755 6.1e-163 lytR K May catalyze the final step in cell wall teichoic acid biosynthesis, the transfer of the anionic cell wall polymers (APs) from their lipid-linked precursor to the cell wall peptidoglycan (PG)
HPPHLOHB_03756 8.2e-218 mnaA 5.1.3.14 M Belongs to the UDP-N-acetylglucosamine 2-epimerase family
HPPHLOHB_03757 9e-164 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
HPPHLOHB_03758 0.0 ggaB GT2 M CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
HPPHLOHB_03759 8.1e-257 ggaA M Glycosyltransferase like family 2
HPPHLOHB_03761 1.6e-100 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
HPPHLOHB_03762 1.8e-279 tagH 3.6.3.38, 3.6.3.40 GM Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system
HPPHLOHB_03763 1.1e-150 tagG GM Transport permease protein
HPPHLOHB_03764 0.0 tagF 2.7.8.12 M glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HPPHLOHB_03765 0.0 tagE 2.4.1.52 GT4 M Glycosyl transferase 1 domain A
HPPHLOHB_03766 5.7e-70 tagD 2.7.7.15, 2.7.7.39 IM Cytidylyltransferase
HPPHLOHB_03767 1.8e-144 tagA 2.4.1.187 GT26 M Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid
HPPHLOHB_03768 5e-215 tagB 2.7.8.14, 2.7.8.44, 2.7.8.47 M glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HPPHLOHB_03769 1.2e-260
HPPHLOHB_03770 7.2e-217 atl 3.2.1.96, 3.5.1.28 GH73 G Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
HPPHLOHB_03771 7.1e-191 pmi 5.3.1.8 G mannose-6-phosphate isomerase
HPPHLOHB_03772 3.5e-266 gerBA EG Spore germination protein
HPPHLOHB_03773 7.5e-200 gerBB E Spore germination protein
HPPHLOHB_03774 7.6e-216 gerAC S Spore germination protein
HPPHLOHB_03775 1.9e-248 ywtG EGP Major facilitator Superfamily
HPPHLOHB_03776 8.4e-171 ywtF K Transcriptional regulator
HPPHLOHB_03777 7e-161 ywtE 3.1.3.104 S hydrolases of the HAD superfamily
HPPHLOHB_03778 5.4e-240 pgdS CBM50 M COG0791 Cell wall-associated hydrolases (invasion-associated proteins)
HPPHLOHB_03779 3.6e-21 ywtC
HPPHLOHB_03780 1.7e-218 capA M enzyme of poly-gamma-glutamate biosynthesis (capsule formation)
HPPHLOHB_03781 8.6e-70 pgsC S biosynthesis protein
HPPHLOHB_03782 6.1e-224 murD 6.3.2.9 M COG0769 UDP-N-acetylmuramyl tripeptide synthase
HPPHLOHB_03783 1.9e-178 rbsR K transcriptional
HPPHLOHB_03784 2.9e-162 rbsK 2.7.1.15, 2.7.1.4 H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPPHLOHB_03785 2.8e-64 rbsD 5.4.99.62 G Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose
HPPHLOHB_03786 2.3e-276 rbsA 3.6.3.17 G Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system
HPPHLOHB_03787 1.4e-154 rbsC G Belongs to the binding-protein-dependent transport system permease family
HPPHLOHB_03788 4.4e-161 rbsB G COG1879 ABC-type sugar transport system, periplasmic component
HPPHLOHB_03789 4.6e-94 batE T Sh3 type 3 domain protein
HPPHLOHB_03790 3.6e-48 ywsA S Protein of unknown function (DUF3892)
HPPHLOHB_03791 1.5e-97 ywrO S NADPH-quinone reductase (modulator of drug activity B)
HPPHLOHB_03792 1.3e-145 budA 4.1.1.5 H Alpha-acetolactate decarboxylase
HPPHLOHB_03793 0.0 alsS 2.2.1.6 EH Belongs to the TPP enzyme family
HPPHLOHB_03794 1.1e-169 alsR K LysR substrate binding domain
HPPHLOHB_03795 1.9e-220 ywrK P Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPPHLOHB_03796 7.5e-126 ywrJ
HPPHLOHB_03797 7.6e-131 cotB
HPPHLOHB_03798 1.2e-210 cotH M Spore Coat
HPPHLOHB_03799 3.7e-12
HPPHLOHB_03800 8.1e-111 ywrF S COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HPPHLOHB_03801 2.9e-54 S Domain of unknown function (DUF4181)
HPPHLOHB_03802 9.6e-310 ggt 2.3.2.2, 3.4.19.13 E gamma-glutamyltransferase
HPPHLOHB_03803 2.1e-82 ywrC K Transcriptional regulator
HPPHLOHB_03804 2.4e-104 ywrB P Chromate transporter
HPPHLOHB_03805 6.9e-90 ywrA P COG2059 Chromate transport protein ChrA
HPPHLOHB_03807 2.7e-102 ywqN S NAD(P)H-dependent
HPPHLOHB_03808 2.9e-162 K Transcriptional regulator
HPPHLOHB_03809 4.5e-137 nfi 3.1.21.7 L DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA
HPPHLOHB_03810 1.7e-52 S MORN repeat variant
HPPHLOHB_03811 0.0 ywqJ L nucleic acid phosphodiester bond hydrolysis
HPPHLOHB_03812 1.3e-38 ywqI S Family of unknown function (DUF5344)
HPPHLOHB_03813 3.3e-15 S Domain of unknown function (DUF5082)
HPPHLOHB_03814 3.4e-154 ywqG S Domain of unknown function (DUF1963)
HPPHLOHB_03815 3e-248 ugd 1.1.1.22 M Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HPPHLOHB_03816 1.4e-141 ywqE 3.1.3.48 GM COG4464 Capsular polysaccharide biosynthesis protein
HPPHLOHB_03817 1.1e-119 ywqD 2.7.10.1 D COG0489 ATPases involved in chromosome partitioning
HPPHLOHB_03818 2e-116 ywqC M biosynthesis protein
HPPHLOHB_03819 1.2e-17
HPPHLOHB_03820 3.8e-309 ywqB S SWIM zinc finger
HPPHLOHB_03821 0.0 ywqA L COG0553 Superfamily II DNA RNA helicases, SNF2 family
HPPHLOHB_03822 3.6e-157 ywpJ 3.1.3.104 S hydrolases of the HAD superfamily
HPPHLOHB_03823 8.8e-139 glcR K COG1349 Transcriptional regulators of sugar metabolism
HPPHLOHB_03824 9.8e-58 ssbB L Single-stranded DNA-binding protein
HPPHLOHB_03825 1.3e-66 ywpG
HPPHLOHB_03826 1.1e-66 ywpF S YwpF-like protein
HPPHLOHB_03827 8e-51 srtA 3.4.22.70 M Sortase family
HPPHLOHB_03828 1.9e-153 ywpD T Histidine kinase
HPPHLOHB_03829 1.5e-54 mscL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
HPPHLOHB_03830 4.6e-82 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
HPPHLOHB_03831 2.1e-199 S aspartate phosphatase
HPPHLOHB_03832 1.5e-141 flhP N flagellar basal body
HPPHLOHB_03833 6.9e-126 flhO N flagellar basal body
HPPHLOHB_03834 3.5e-180 mbl D Rod shape-determining protein
HPPHLOHB_03835 3e-44 spoIIID K Stage III sporulation protein D
HPPHLOHB_03836 2.1e-70 ywoH K COG1846 Transcriptional regulators
HPPHLOHB_03837 2.7e-211 ywoG EGP Major facilitator Superfamily
HPPHLOHB_03838 1.2e-231 ywoF P Right handed beta helix region
HPPHLOHB_03839 3e-281 ybbW FH COG1953 Cytosine uracil thiamine allantoin permeases
HPPHLOHB_03840 4.4e-242 ywoD EGP Major facilitator superfamily
HPPHLOHB_03841 4e-104 phzA Q Isochorismatase family
HPPHLOHB_03842 1.2e-77
HPPHLOHB_03843 2.5e-225 amt P Ammonium transporter
HPPHLOHB_03844 1.6e-58 nrgB K Belongs to the P(II) protein family
HPPHLOHB_03845 3.4e-103 bcrC 3.6.1.27 I COG0671 Membrane-associated phospholipid phosphatase
HPPHLOHB_03846 3.5e-73 ywnJ S VanZ like family
HPPHLOHB_03847 5.5e-126 spoIIQ M COG0739 Membrane proteins related to metalloendopeptidases
HPPHLOHB_03848 6.4e-90 ywnH 2.3.1.183 M COG1247 Sortase and related acyltransferases
HPPHLOHB_03849 2.7e-14 ywnC S Family of unknown function (DUF5362)
HPPHLOHB_03850 2.2e-70 ywnF S Family of unknown function (DUF5392)
HPPHLOHB_03851 1.2e-277 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPPHLOHB_03852 4.1e-144 mta K transcriptional
HPPHLOHB_03853 2.6e-59 ywnC S Family of unknown function (DUF5362)
HPPHLOHB_03854 1.6e-114 ywnB S NAD(P)H-binding
HPPHLOHB_03855 1.7e-64 ywnA K Transcriptional regulator
HPPHLOHB_03856 0.0 ureC 3.5.1.5 E Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family
HPPHLOHB_03857 5.9e-64 ureB 3.5.1.5 E Belongs to the urease beta subunit family
HPPHLOHB_03858 6.3e-51 ureA 3.5.1.5 E Belongs to the urease gamma subunit family
HPPHLOHB_03860 3.8e-11 csbD K CsbD-like
HPPHLOHB_03861 3e-84 ywmF S Peptidase M50
HPPHLOHB_03862 1.3e-103 S response regulator aspartate phosphatase
HPPHLOHB_03863 7e-192 moaA 4.1.99.22, 4.6.1.17 H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPPHLOHB_03864 2.6e-146 fdhD C Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPPHLOHB_03866 7.2e-121 ywmD S protein containing a von Willebrand factor type A (vWA) domain
HPPHLOHB_03867 1.7e-122 ywmC S protein containing a von Willebrand factor type A (vWA) domain
HPPHLOHB_03868 2e-178 spoIID D Stage II sporulation protein D
HPPHLOHB_03869 1.2e-241 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPPHLOHB_03870 1.6e-134 ywmB S TATA-box binding
HPPHLOHB_03871 1.3e-32 ywzB S membrane
HPPHLOHB_03872 4.3e-88 ywmA
HPPHLOHB_03873 5.9e-54 atpC C Produces ATP from ADP in the presence of a proton gradient across the membrane
HPPHLOHB_03874 1.2e-266 atpD 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HPPHLOHB_03875 1.1e-150 atpG C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HPPHLOHB_03876 6.9e-281 atpA 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HPPHLOHB_03877 1.1e-90 atpH C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPPHLOHB_03878 3.8e-45 atpF C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HPPHLOHB_03879 1.6e-26 atpE C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPPHLOHB_03880 4.6e-129 atpB C it plays a direct role in the translocation of protons across the membrane
HPPHLOHB_03881 2.5e-62 atpI S ATP synthase
HPPHLOHB_03882 4.7e-114 upp 2.4.2.9 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HPPHLOHB_03883 2.1e-238 glyA 2.1.2.1 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPPHLOHB_03884 7.2e-95 ywlG S Belongs to the UPF0340 family
HPPHLOHB_03885 1.7e-81 rpiB 5.3.1.6 G Ribose 5-phosphate isomerase
HPPHLOHB_03886 1.7e-78 ywlE 3.1.3.48, 3.9.1.2, 5.3.1.6 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPPHLOHB_03887 1.7e-91 mntP P Probably functions as a manganese efflux pump
HPPHLOHB_03888 1.2e-196 ywlC 2.7.7.87, 3.1.3.48 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
HPPHLOHB_03889 1.2e-76 ywlB 1.20.4.1, 2.3.1.1 E Belongs to the acetyltransferase family. ArgA subfamily
HPPHLOHB_03890 6.1e-112 spoIIR S stage II sporulation protein R
HPPHLOHB_03891 3.4e-56 ywlA S Uncharacterised protein family (UPF0715)
HPPHLOHB_03893 2.3e-159 prmC 2.1.1.297 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
HPPHLOHB_03894 9.5e-192 prfA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPPHLOHB_03895 8.2e-69 yaeR E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HPPHLOHB_03896 1.7e-91 racA K Required for the formation of axial filaments and for anchoring the origin regions at the cell poles in sporulating cells, thus ensuring proper chromosome segregation in the prespore. Binds in a dispersed manner throughout the chromosome but preferentially to sites clustered in the origin portion of the chromosome, causing condensation of the chromosome and its remodeling into an elongated, anchored structure
HPPHLOHB_03897 8.6e-160 ywkB S Membrane transport protein
HPPHLOHB_03898 0.0 sfcA 1.1.1.38 C malic enzyme
HPPHLOHB_03899 2.4e-104 tdk 2.7.1.21 F thymidine kinase
HPPHLOHB_03900 1.1e-32 rpmE J Binds the 23S rRNA
HPPHLOHB_03901 2.8e-238 rho K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HPPHLOHB_03902 1.9e-175 glpX 3.1.3.11, 3.1.3.37 G fructose-1,6-bisphosphatase
HPPHLOHB_03903 8.6e-240 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPPHLOHB_03904 1.5e-112 tal 2.2.1.2 G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HPPHLOHB_03905 7.2e-158 fbaA 4.1.2.13, 4.1.2.29 G Aldolase
HPPHLOHB_03906 1.1e-62 spo0F T COG0784 FOG CheY-like receiver
HPPHLOHB_03907 2.4e-92 ywjG S Domain of unknown function (DUF2529)
HPPHLOHB_03908 0.0 pyrG 6.3.4.2 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
HPPHLOHB_03909 1.5e-49 rpoE K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
HPPHLOHB_03910 2.6e-211 acdA 1.3.8.1, 1.3.8.7 I acyl-CoA dehydrogenase
HPPHLOHB_03911 0.0 fadF C COG0247 Fe-S oxidoreductase
HPPHLOHB_03912 2.3e-223 clsB I Belongs to the phospholipase D family. Cardiolipin synthase subfamily
HPPHLOHB_03913 6.6e-184 uvsE L Component in a DNA repair pathway. Removal of UV-light damaged nucleotides. Recognizes pyrimidine dimers and cleave a phosphodiester bond immediately 5' to the lesion
HPPHLOHB_03914 2.7e-42 ywjC
HPPHLOHB_03915 4.8e-96 ywjB H RibD C-terminal domain
HPPHLOHB_03916 0.0 ywjA V ABC transporter
HPPHLOHB_03917 6.4e-287 ywiE I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPPHLOHB_03918 1.8e-124 narI 1.7.5.1 C nitrate reductase, gamma
HPPHLOHB_03919 2.4e-98 narJ 1.7.5.1 C nitrate reductase
HPPHLOHB_03920 1e-297 narH 1.7.5.1 C Nitrate reductase, beta
HPPHLOHB_03921 0.0 narG 1.7.5.1 C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HPPHLOHB_03922 7e-86 arfM T cyclic nucleotide binding
HPPHLOHB_03923 4.3e-140 ywiC S YwiC-like protein
HPPHLOHB_03924 5.3e-130 fnr K helix_turn_helix, cAMP Regulatory protein
HPPHLOHB_03925 9.8e-214 narK P COG2223 Nitrate nitrite transporter
HPPHLOHB_03926 0.0 argS 6.1.1.19 J Arginyl-tRNA synthetase
HPPHLOHB_03927 4.7e-73 ywiB S protein conserved in bacteria
HPPHLOHB_03928 1e-07 S Bacteriocin subtilosin A
HPPHLOHB_03929 2.6e-271 C Fe-S oxidoreductases
HPPHLOHB_03931 3.3e-132 cbiO V ABC transporter
HPPHLOHB_03932 3.1e-237 mgtA 3.6.3.2 P ATPase, P-type transporting, HAD superfamily, subfamily IC
HPPHLOHB_03933 2.7e-219 2.7.1.26, 2.7.7.2 L Peptidase, M16
HPPHLOHB_03934 1.2e-249 L Peptidase, M16
HPPHLOHB_03936 2.9e-249 ywhL CO amine dehydrogenase activity
HPPHLOHB_03937 2.5e-205 ywhK CO amine dehydrogenase activity
HPPHLOHB_03938 2.3e-79 S aspartate phosphatase
HPPHLOHB_03940 1e-84 ywhH S Aminoacyl-tRNA editing domain
HPPHLOHB_03941 9.2e-169 speB 3.5.3.11 E Belongs to the arginase family
HPPHLOHB_03942 1.4e-158 speE 2.5.1.16 E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HPPHLOHB_03943 0.0 pbpG 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
HPPHLOHB_03944 5.2e-95 ywhD S YwhD family
HPPHLOHB_03945 5.1e-119 ywhC S Peptidase family M50
HPPHLOHB_03946 2.7e-25 dmpI 5.3.2.6 G 4-oxalocrotonate tautomerase
HPPHLOHB_03947 3.3e-71 ywhA K Transcriptional regulator
HPPHLOHB_03948 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HPPHLOHB_03950 2.6e-242 mmr U Major Facilitator Superfamily
HPPHLOHB_03951 2.8e-79 yffB K Transcriptional regulator
HPPHLOHB_03952 5.4e-89 ywgA 2.1.1.72, 3.1.21.3
HPPHLOHB_03953 1.8e-256 ywfO S COG1078 HD superfamily phosphohydrolases
HPPHLOHB_03954 3.1e-36 ywzC S Belongs to the UPF0741 family
HPPHLOHB_03955 1.6e-111 rsfA_1
HPPHLOHB_03956 5.2e-159 ywfM EG EamA-like transporter family
HPPHLOHB_03957 6.6e-156 lipL 2.3.1.200, 2.3.1.204 H Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes
HPPHLOHB_03958 9.2e-164 cysL K Transcriptional regulator
HPPHLOHB_03959 6.6e-176 pta 2.3.1.19, 2.3.1.8, 3.6.3.21 C In Salmonella this enzyme is required for ethanolamine catabolism
HPPHLOHB_03960 1.1e-146 ywfI C May function as heme-dependent peroxidase
HPPHLOHB_03961 4e-139 IQ Enoyl-(Acyl carrier protein) reductase
HPPHLOHB_03962 2.7e-235 ywfG 2.6.1.83 E Aminotransferase class I and II
HPPHLOHB_03963 2.9e-210 bacE EGP Major facilitator Superfamily
HPPHLOHB_03964 3.6e-271 purD 6.3.2.49, 6.3.4.13 F Part of the bacABCDEFG operon responsible for the biosynthesis of bacilysin, an irreversible inactivator of the glutaminase domain of glucosamine synthetase. Catalyzes the formation of alpha-dipeptides from various L-amino acids in the presence of ATP. In vivo catalyzes the ligation of L-alanine and L-anticapsin (epoxycyclohexanonyl-Ala) to produce the final bacilysin antibiotic (L-Ala-L-4S-cyclohexenonyl-Ala dipeptide)
HPPHLOHB_03965 1.3e-139 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HPPHLOHB_03966 1.3e-136 bacB 5.3.3.19, 5.4.99.5 S Part of the bacABCDEF operon responsible for the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase. BacB catalyzes the allylic isomerization of the
HPPHLOHB_03967 8.6e-113 pheA 1.1.1.3, 1.3.1.12, 4.1.1.100, 4.2.1.51, 5.4.99.5 E Part of the bacABCDEF operon responsible for the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase. BacA is an unusual prephenate decarboxylase that avoids the typical aromatization of the cyclohexadienol ring of prephenate. BacA catalyzes the protonation of prephenate (1-carboxy-4-hydroxy-alpha-oxo-2,5-cyclohexadiene-1- propanoic acid) at C6 position, followed by a decarboxylation to produce the endocyclic-delta(4),delta(8)-7R-dihydro- hydroxyphenylpyruvate (en-H2HPP). En-H2HPP is able to undergo a slow nonenzymatic isomerization to produce the exocyclic- delta(3),delta(5)-dihydro-hydroxyphenylpyruvate (ex-H2HPP). BacA isomerizes only the pro-R double bond in prephenate
HPPHLOHB_03968 4.6e-206 ywfA EGP Major facilitator Superfamily
HPPHLOHB_03969 4e-262 lysP E amino acid
HPPHLOHB_03970 0.0 rocB E arginine degradation protein
HPPHLOHB_03971 1.4e-297 putA 1.2.1.88, 1.5.5.2 C Belongs to the aldehyde dehydrogenase family. RocA subfamily
HPPHLOHB_03972 7.5e-244 rocG 1.4.1.2, 1.4.1.3 E Belongs to the Glu Leu Phe Val dehydrogenases family
HPPHLOHB_03973 1.8e-78
HPPHLOHB_03974 3.5e-87 spsL 5.1.3.13 M Spore Coat
HPPHLOHB_03975 5.3e-161 spsK 1.1.1.133 M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
HPPHLOHB_03976 1e-181 rfbB 4.2.1.46 M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
HPPHLOHB_03977 1.9e-138 spsI 2.7.7.24 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HPPHLOHB_03978 1.7e-190 spsG M Spore Coat
HPPHLOHB_03979 9.7e-132 spsF M Spore Coat
HPPHLOHB_03980 3.2e-214 spsE 2.5.1.56 M acid synthase
HPPHLOHB_03981 4e-164 spsD 2.3.1.210 K Spore Coat
HPPHLOHB_03982 1.6e-224 spsC E Belongs to the DegT DnrJ EryC1 family
HPPHLOHB_03983 1.5e-269 spsB M Capsule polysaccharide biosynthesis protein
HPPHLOHB_03984 2.8e-145 spsA M Spore Coat
HPPHLOHB_03985 4.8e-75 gerQ S Essential for the localization of CwlJ in the spore coat and for spore germination triggered by calcium and dipicolinic acid (DPA). Its assembly into the spore coat is dependent on the coat morphogenetic proteins CotE and SpoIVA
HPPHLOHB_03986 4.3e-59 ywdK S small membrane protein
HPPHLOHB_03987 1.3e-238 ywdJ F Xanthine uracil
HPPHLOHB_03988 7.7e-49 ywdI S Family of unknown function (DUF5327)
HPPHLOHB_03989 5.9e-263 ywdH 1.2.1.3 C Belongs to the aldehyde dehydrogenase family
HPPHLOHB_03990 5e-130 ung 3.2.2.27 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HPPHLOHB_03991 1.1e-152 ywdF GT2,GT4 S Glycosyltransferase like family 2
HPPHLOHB_03993 1.4e-113 ywdD
HPPHLOHB_03994 1.3e-57 pex K Transcriptional regulator PadR-like family
HPPHLOHB_03995 9.3e-147 thiD 2.5.1.3, 2.7.1.35, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Phosphomethylpyrimidine kinase
HPPHLOHB_03996 2e-28 ywdA
HPPHLOHB_03997 9.5e-296 scrB 3.2.1.26, 3.2.1.65, 3.2.1.80 GH32 G invertase
HPPHLOHB_03998 3.9e-254 scrA 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
HPPHLOHB_03999 1e-139 focA P Formate/nitrite transporter
HPPHLOHB_04000 2.4e-150 sacT K transcriptional antiterminator
HPPHLOHB_04002 0.0 vpr O Belongs to the peptidase S8 family
HPPHLOHB_04003 5.1e-187 ywcH C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPPHLOHB_04004 7.2e-138 nfrA 1.5.1.38, 1.5.1.39 C Oxidoreductase
HPPHLOHB_04005 2.9e-202 rodA D Belongs to the SEDS family
HPPHLOHB_04006 6e-39 ywcE S Required for proper spore morphogenesis. Important for spore germination
HPPHLOHB_04007 2.6e-64 qoxD 1.10.3.12, 1.9.3.1 C quinol oxidase, subunit
HPPHLOHB_04008 1.2e-111 qoxC 1.10.3.12, 1.9.3.1 C quinol oxidase, subunit
HPPHLOHB_04009 0.0 qoxB 1.10.3.12, 1.9.3.1 C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPPHLOHB_04010 2.1e-177 cyoA 1.10.3.10, 1.10.3.12 C Catalyzes quinol oxidation with the concomitant reduction of oxygen to water. Subunit II transfers the electrons from a quinol to the binuclear center of the catalytic subunit I
HPPHLOHB_04011 1e-35 ywzA S membrane
HPPHLOHB_04012 3.7e-306 galT 2.7.7.12 G UDP-glucose--hexose-1-phosphate uridylyltransferase
HPPHLOHB_04013 6.2e-229 galK 2.7.1.6 G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HPPHLOHB_04014 9.5e-60 gtcA S GtrA-like protein
HPPHLOHB_04015 2.2e-122 ywcC K transcriptional regulator
HPPHLOHB_04017 9.8e-49 ywcB S Protein of unknown function, DUF485
HPPHLOHB_04018 1.4e-268 ywcA S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPPHLOHB_04019 1.9e-112 ywbO Q dithiol-disulfide isomerase involved in polyketide biosynthesis
HPPHLOHB_04020 2.6e-225 ywbN P Dyp-type peroxidase family protein
HPPHLOHB_04021 2e-187 ycdO P periplasmic lipoprotein involved in iron transport
HPPHLOHB_04022 8.2e-255 P COG0672 High-affinity Fe2 Pb2 permease
HPPHLOHB_04023 4.1e-116 thiE 2.5.1.3, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
HPPHLOHB_04024 2.8e-143 thiM 2.7.1.50 H Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HPPHLOHB_04025 4.3e-153 ywbI K Transcriptional regulator
HPPHLOHB_04026 6.5e-58 ywbH S Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein. When a cell is stressed by the addition of antibiotics or by other factors in the environment, CidA possibly oligomerizes within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are also hypothesized to regulate the subsequent cell lysis by either allowing the murein hydrolases access to the cell wall substrate and or regulating their activity by a
HPPHLOHB_04027 2.3e-111 ywbG M effector of murein hydrolase
HPPHLOHB_04028 1.9e-209 ywbF EGP Major facilitator Superfamily
HPPHLOHB_04029 1.2e-28 ywbE S Uncharacterized conserved protein (DUF2196)
HPPHLOHB_04030 8.9e-223 ywbD 2.1.1.191 J Methyltransferase
HPPHLOHB_04031 4.4e-67 ywbC 4.4.1.5 E glyoxalase
HPPHLOHB_04032 1.8e-127 ywbB S Protein of unknown function (DUF2711)
HPPHLOHB_04033 5.8e-247 celB G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HPPHLOHB_04034 1.6e-277 epr 3.4.21.62 O Belongs to the peptidase S8 family
HPPHLOHB_04035 5.2e-243 scrA 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
HPPHLOHB_04036 4e-153 sacY K transcriptional antiterminator
HPPHLOHB_04037 7e-169 gspA M General stress
HPPHLOHB_04038 1.7e-128 ywaF S Integral membrane protein
HPPHLOHB_04039 8.1e-88 ywaE K Transcriptional regulator
HPPHLOHB_04040 4.4e-233 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPPHLOHB_04041 1.4e-251 ywaD 3.4.11.10, 3.4.11.6 S PA domain
HPPHLOHB_04042 5e-116 ywaC 2.7.6.5 S protein conserved in bacteria
HPPHLOHB_04043 5.4e-167 menA 2.5.1.74 H Belongs to the MenA family. Type 1 subfamily
HPPHLOHB_04044 5e-14 S D-Ala-teichoic acid biosynthesis protein
HPPHLOHB_04045 7.9e-293 dltA 6.1.1.13 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HPPHLOHB_04046 1.2e-232 dltB M membrane protein involved in D-alanine export
HPPHLOHB_04047 1.5e-36 dltC 6.1.1.13 IQ Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HPPHLOHB_04048 2.3e-231 dltD M COG3966 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HPPHLOHB_04049 6.6e-139 dltE M Belongs to the short-chain dehydrogenases reductases (SDR) family
HPPHLOHB_04050 3.1e-206 ilvE 2.6.1.42 E Branched-chain amino acid aminotransferase
HPPHLOHB_04051 1.1e-253 licH 3.2.1.86 GT4 G COG1486 Alpha-galactosidases 6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases
HPPHLOHB_04052 6.7e-38 licA 2.7.1.196, 2.7.1.205 G phosphotransferase system
HPPHLOHB_04053 7.4e-250 licC G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HPPHLOHB_04054 2.3e-50 licB 2.7.1.196, 2.7.1.205 G transporter subunit IIB
HPPHLOHB_04055 0.0 licR 2.7.1.202 GKT Mga helix-turn-helix domain
HPPHLOHB_04056 1.1e-19 yxzF
HPPHLOHB_04057 1e-110 mpg 3.2.2.21 L Belongs to the DNA glycosylase MPG family
HPPHLOHB_04058 0.0 katX 1.11.1.6 P serves to protect cells from the toxic effects of hydrogen peroxide
HPPHLOHB_04059 2.1e-216 yxlH EGP Major facilitator Superfamily
HPPHLOHB_04060 1.8e-139 yxlG S COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
HPPHLOHB_04061 5.1e-167 yxlF V ABC transporter, ATP-binding protein
HPPHLOHB_04062 7.6e-28 yxlE S Phospholipase_D-nuclease N-terminal
HPPHLOHB_04063 1.2e-31
HPPHLOHB_04064 3.9e-48 yxlC S Family of unknown function (DUF5345)
HPPHLOHB_04065 4.7e-91 sigY K Belongs to the sigma-70 factor family. ECF subfamily
HPPHLOHB_04066 2.3e-254 yxlA F Belongs to the purine-cytosine permease (2.A.39) family
HPPHLOHB_04067 8e-162 nnrD 4.2.1.136, 5.1.99.6 G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPPHLOHB_04068 0.0 cydD V ATP-binding protein
HPPHLOHB_04069 0.0 cydD V ATP-binding
HPPHLOHB_04070 2.9e-190 cydB 1.10.3.14 C Cytochrome d ubiquinol oxidase, subunit II
HPPHLOHB_04071 1.3e-268 cydA 1.10.3.14 C oxidase, subunit
HPPHLOHB_04072 1.5e-229 cimH C COG3493 Na citrate symporter
HPPHLOHB_04073 0.0 3.4.24.84 O Peptidase family M48
HPPHLOHB_04075 3e-156 yxkH G Polysaccharide deacetylase
HPPHLOHB_04076 5.9e-205 msmK P Belongs to the ABC transporter superfamily
HPPHLOHB_04077 4.8e-165 lrp QT PucR C-terminal helix-turn-helix domain
HPPHLOHB_04078 2.5e-275 aldY 1.2.1.3 C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
HPPHLOHB_04079 1.9e-147 yxkD S Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPPHLOHB_04080 4.1e-73 yxkC S Domain of unknown function (DUF4352)
HPPHLOHB_04081 4.6e-196 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
HPPHLOHB_04082 1.3e-95 yxkA S Phosphatidylethanolamine-binding protein
HPPHLOHB_04083 1.9e-166 yxjO K LysR substrate binding domain
HPPHLOHB_04084 2.4e-78 S Protein of unknown function (DUF1453)
HPPHLOHB_04085 1.5e-193 yxjM T Signal transduction histidine kinase
HPPHLOHB_04086 8.9e-116 K helix_turn_helix, Lux Regulon
HPPHLOHB_04087 3.6e-235 pepT 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
HPPHLOHB_04090 1e-87 yxjI S LURP-one-related
HPPHLOHB_04091 5.5e-222 yxjG 2.1.1.14 E Methionine synthase
HPPHLOHB_04092 1e-220 yxjG 2.1.1.14 E Methionine synthase
HPPHLOHB_04093 1.3e-137 IQ Catalyzes the formation of acetoacetate from 3-hydroxybutyrate
HPPHLOHB_04094 5.2e-116 scoB 2.8.3.5 I COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit
HPPHLOHB_04095 1.4e-130 scoA 2.8.3.5 I COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HPPHLOHB_04096 2.6e-253 yxjC EG COG2610 H gluconate symporter and related permeases
HPPHLOHB_04097 3.1e-161 rlmA 2.1.1.187 Q Methyltransferase domain
HPPHLOHB_04098 1.9e-212 nupG F Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPPHLOHB_04099 1.2e-22 T Domain of unknown function (DUF4163)
HPPHLOHB_04100 2.7e-48 yxiS
HPPHLOHB_04101 0.0 katE 1.11.1.6, 3.5.1.124 P serves to protect cells from the toxic effects of hydrogen peroxide
HPPHLOHB_04102 6.6e-224 citH C Citrate transporter
HPPHLOHB_04103 5e-144 exoK GH16 M licheninase activity
HPPHLOHB_04104 8.3e-151 licT K transcriptional antiterminator
HPPHLOHB_04105 6.6e-114
HPPHLOHB_04106 3e-232 yxiO S COG2270 Permeases of the major facilitator superfamily
HPPHLOHB_04107 1e-265 dbpA 3.6.4.13 JKL DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes
HPPHLOHB_04108 7.5e-219 3.2.1.14 GH18 E GDSL-like Lipase/Acylhydrolase
HPPHLOHB_04111 1.6e-48 yxiJ S YxiJ-like protein
HPPHLOHB_04112 1.2e-96 yxiI S Protein of unknown function (DUF2716)
HPPHLOHB_04113 3.8e-81
HPPHLOHB_04114 4.9e-46
HPPHLOHB_04115 3.7e-75 yxiG
HPPHLOHB_04116 6.4e-63
HPPHLOHB_04117 1.7e-84
HPPHLOHB_04118 1.5e-71 yxxG
HPPHLOHB_04119 0.0 wapA M COG3209 Rhs family protein
HPPHLOHB_04120 2.9e-168 yxxF EG EamA-like transporter family
HPPHLOHB_04121 1.1e-72 yxiE T Belongs to the universal stress protein A family
HPPHLOHB_04122 6.6e-281 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
HPPHLOHB_04123 0.0 bglF 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
HPPHLOHB_04124 3.6e-51
HPPHLOHB_04125 2.2e-78 S SMI1 / KNR4 family
HPPHLOHB_04126 0.0 S nuclease activity
HPPHLOHB_04127 3.6e-39 yxiC S Family of unknown function (DUF5344)
HPPHLOHB_04128 2.1e-21 S Domain of unknown function (DUF5082)
HPPHLOHB_04129 6.3e-284 yxiA 3.2.1.99 GH43 G Belongs to the glycosyl hydrolase 43 family
HPPHLOHB_04130 5e-78 hutP K Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization
HPPHLOHB_04131 2.3e-284 hutH 4.3.1.3 E Histidine ammonia-lyase
HPPHLOHB_04132 0.0 hutU 4.2.1.49 E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HPPHLOHB_04133 1.2e-238 hutI 3.5.2.7 Q Imidazolone-5-propionate hydrolase
HPPHLOHB_04134 8e-182 hutG 3.5.3.11, 3.5.3.8 E Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide
HPPHLOHB_04135 6.1e-252 lysP E amino acid
HPPHLOHB_04136 4.2e-234 pdp 2.4.2.2, 2.4.2.4 F phosphorylase
HPPHLOHB_04137 9.8e-206 nupC F Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPPHLOHB_04138 7e-116 deoC 4.1.2.4 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HPPHLOHB_04139 3.5e-174 deoR K COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain
HPPHLOHB_04140 3e-153 yxxB S Domain of Unknown Function (DUF1206)
HPPHLOHB_04141 6.8e-201 eutH E Ethanolamine utilisation protein, EutH
HPPHLOHB_04142 2e-255 yxeQ S MmgE/PrpD family
HPPHLOHB_04143 3.8e-215 yxeP 3.5.1.47 E hydrolase activity
HPPHLOHB_04144 5.4e-133 yxeO 3.6.3.21 P ABC transporter, ATP-binding protein
HPPHLOHB_04145 5.4e-108 yxeN P COG0765 ABC-type amino acid transport system, permease component
HPPHLOHB_04146 2.5e-144 yxeM M Belongs to the bacterial solute-binding protein 3 family
HPPHLOHB_04147 7.3e-94 yxeL K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HPPHLOHB_04148 2.2e-254 yxeK C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPPHLOHB_04150 8.8e-192 yxeI 3.5.1.24 M Linear amide C-N hydrolases, choloylglycine hydrolase family
HPPHLOHB_04151 6.2e-151 yidA S hydrolases of the HAD superfamily
HPPHLOHB_04154 1.3e-20 yxeE
HPPHLOHB_04155 1.9e-16 yxeD
HPPHLOHB_04156 8.5e-69
HPPHLOHB_04157 6e-177 fhuD P ABC transporter
HPPHLOHB_04158 1.5e-58 yxeA S Protein of unknown function (DUF1093)
HPPHLOHB_04159 0.0 yxdM V ABC transporter (permease)
HPPHLOHB_04160 9.4e-141 yxdL V ABC transporter, ATP-binding protein
HPPHLOHB_04161 1.3e-182 T PhoQ Sensor
HPPHLOHB_04162 4.2e-124 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HPPHLOHB_04163 5.4e-161 iolJ 4.1.2.13, 4.1.2.29 F Produces dihydroxyacetone phosphate (DHAP or glycerone phosphate) and malonic semialdehyde (MSA or 3-oxopropanoate) from 6-phospho-5-dehydro-2-deoxy-D-gluconate (DKGP)
HPPHLOHB_04164 1.9e-139 iolI 5.3.99.11 G Involved in the reversible interconverion of 2-keto-myo- inositol (2KMI, inosose or 2,4,6 3,5-pentahydroxycyclohexanone) to 1-keto-D-chiro-inositol (1KDCI or 2,3,5 4,6- pentahydroxycyclohexanone)
HPPHLOHB_04165 2.3e-167 iolH G Xylose isomerase-like TIM barrel
HPPHLOHB_04166 2.8e-196 iolG 1.1.1.18, 1.1.1.369 S Involved in the oxidation of myo-inositol (MI) and D- chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively
HPPHLOHB_04167 1.3e-235 iolF EGP Major facilitator Superfamily
HPPHLOHB_04168 2.1e-176 iolE 4.2.1.44 G Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol)
HPPHLOHB_04169 0.0 iolD 3.7.1.22 E Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG)
HPPHLOHB_04170 2.9e-179 iolC 2.7.1.92 G Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D- gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5- dehydro-2-deoxy-D-gluconate (DKGP)
HPPHLOHB_04171 1.1e-155 iolB 5.3.1.30 G Involved in the isomerization of 5-deoxy-glucuronate (5DG) to 5-dehydro-2-deoxy-D-gluconate (DKG or 2-deoxy-5-keto-D- gluconate)
HPPHLOHB_04172 1.4e-281 iolA 1.2.1.18, 1.2.1.27 C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
HPPHLOHB_04173 3.3e-138 iolR K COG1349 Transcriptional regulators of sugar metabolism
HPPHLOHB_04174 3.7e-176 iolS C Aldo keto reductase
HPPHLOHB_04176 8.3e-48 yxcD S Protein of unknown function (DUF2653)
HPPHLOHB_04177 2.3e-246 csbC EGP Major facilitator Superfamily
HPPHLOHB_04178 0.0 htpG O Molecular chaperone. Has ATPase activity
HPPHLOHB_04180 5.7e-152 IQ Enoyl-(Acyl carrier protein) reductase
HPPHLOHB_04181 2.2e-215 yxbF K Bacterial regulatory proteins, tetR family
HPPHLOHB_04182 1.4e-248 alkH 1.2.1.3 C Belongs to the aldehyde dehydrogenase family
HPPHLOHB_04183 1.6e-85 yxbD 3.2.2.20 K Acetyltransferase (GNAT) domain
HPPHLOHB_04184 2.2e-187 yxbC 1.14.11.47 S A domain family that is part of the cupin metalloenzyme superfamily.
HPPHLOHB_04185 3.3e-127 yxbB Q Met-10+ like-protein
HPPHLOHB_04186 4.9e-44 S Coenzyme PQQ synthesis protein D (PqqD)
HPPHLOHB_04187 1.1e-86 yxnB
HPPHLOHB_04188 0.0 asnB 6.3.5.4 E Asparagine synthase
HPPHLOHB_04189 7.6e-214 yxaM U MFS_1 like family
HPPHLOHB_04190 6.8e-93 S PQQ-like domain
HPPHLOHB_04191 3.5e-65 S Family of unknown function (DUF5391)
HPPHLOHB_04192 1.1e-75 yxaI S membrane protein domain
HPPHLOHB_04193 1.4e-228 P Protein of unknown function (DUF418)
HPPHLOHB_04194 1.5e-199 yxaG 1.13.11.24 S AraC-like ligand binding domain
HPPHLOHB_04195 7.1e-101 yxaF K Transcriptional regulator
HPPHLOHB_04196 2.3e-201 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
HPPHLOHB_04197 4.4e-71 yxaD K helix_turn_helix multiple antibiotic resistance protein
HPPHLOHB_04198 5.2e-50 S LrgA family
HPPHLOHB_04199 2.6e-118 yxaC M effector of murein hydrolase
HPPHLOHB_04200 1.3e-193 yxaB GM Polysaccharide pyruvyl transferase
HPPHLOHB_04201 7e-209 glxK 2.7.1.165 G Belongs to the glycerate kinase type-1 family
HPPHLOHB_04202 7.3e-127 gntR K transcriptional
HPPHLOHB_04203 4.6e-304 gntK 2.7.1.12, 2.7.1.17, 2.7.1.5 G Belongs to the FGGY kinase family
HPPHLOHB_04204 4.5e-231 gntP EG COG2610 H gluconate symporter and related permeases
HPPHLOHB_04205 3.8e-273 gnd 1.1.1.343, 1.1.1.44 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPPHLOHB_04206 2.1e-105 ahpC 1.11.1.15 O Alkyl hydroperoxide reductase
HPPHLOHB_04207 3.8e-287 ahpF O Alkyl hydroperoxide reductase
HPPHLOHB_04208 6.4e-292 bglA 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
HPPHLOHB_04209 2.5e-19 bglF G phosphotransferase system
HPPHLOHB_04210 1.3e-128 yydK K Transcriptional regulator
HPPHLOHB_04211 7.6e-13
HPPHLOHB_04212 3.3e-119 S ABC-2 family transporter protein
HPPHLOHB_04213 1.8e-110 prrC P ABC transporter
HPPHLOHB_04214 8.4e-134 yydH O Peptidase M50
HPPHLOHB_04215 7.7e-185 S Radical SAM superfamily
HPPHLOHB_04216 8e-12
HPPHLOHB_04217 0.0 fbp 3.1.3.11 G Firmicute fructose-1,6-bisphosphatase
HPPHLOHB_04218 0.0 S Uncharacterised protein conserved in bacteria (DUF2326)
HPPHLOHB_04219 3.5e-65
HPPHLOHB_04220 7.3e-280 S Calcineurin-like phosphoesterase
HPPHLOHB_04221 5.2e-81 rlmH 2.1.1.177 J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HPPHLOHB_04222 1.1e-09 S YyzF-like protein
HPPHLOHB_04223 4.2e-71
HPPHLOHB_04224 3e-234 fdhA 1.1.1.1, 1.1.1.14, 1.1.1.284, 1.2.1.46 E COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
HPPHLOHB_04226 2.1e-33 yycQ S Protein of unknown function (DUF2651)
HPPHLOHB_04227 1.6e-221 yycP
HPPHLOHB_04228 5.8e-132 yycO S Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HPPHLOHB_04229 3.1e-86 yycN 2.3.1.128 K Acetyltransferase
HPPHLOHB_04230 5e-188 S aspartate phosphatase
HPPHLOHB_04232 2.3e-167 rocF 3.5.3.1, 3.5.3.11 E Belongs to the arginase family
HPPHLOHB_04233 9.7e-261 rocE E amino acid
HPPHLOHB_04234 1.7e-234 rocD 2.6.1.11, 2.6.1.13, 2.6.1.17 E Catalyzes the interconversion of ornithine to glutamate semialdehyde
HPPHLOHB_04235 1.5e-258 rocR KT COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains
HPPHLOHB_04236 8.4e-221 htrA 3.4.21.107 O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPPHLOHB_04237 8.7e-150 vicX 3.1.26.11 S COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I
HPPHLOHB_04238 7.3e-155 yycI S protein conserved in bacteria
HPPHLOHB_04239 3.6e-260 yycH S protein conserved in bacteria
HPPHLOHB_04240 0.0 vicK 2.7.13.3 T Histidine kinase
HPPHLOHB_04241 1.1e-132 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HPPHLOHB_04246 1.7e-248 purA 6.3.4.4 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPPHLOHB_04247 8e-78 yycE 3.4.21.26, 5.3.1.24 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HPPHLOHB_04248 3e-251 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
HPPHLOHB_04249 1.9e-29 yycD S Uncharacterized protein conserved in bacteria (DUF2188)
HPPHLOHB_04251 1.9e-15 yycC K YycC-like protein
HPPHLOHB_04252 8.4e-221 yeaN P COG2807 Cyanate permease
HPPHLOHB_04253 0.0 yycA M COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HPPHLOHB_04254 2.2e-73 rplI J binds to the 23S rRNA
HPPHLOHB_04255 0.0 yybT T signaling protein consisting of a modified GGDEF domain and a DHH domain
HPPHLOHB_04256 2.9e-160 yybS S membrane
HPPHLOHB_04258 3.9e-84 cotF M Spore coat protein
HPPHLOHB_04259 1.4e-68 ydeP3 K Transcriptional regulator
HPPHLOHB_04260 1.1e-164 ppaC 3.6.1.1 C Inorganic pyrophosphatase
HPPHLOHB_04261 1.3e-70
HPPHLOHB_04263 2.3e-240 yybO G COG0477 Permeases of the major facilitator superfamily
HPPHLOHB_04264 1e-16
HPPHLOHB_04265 1.3e-78 yybN S Protein of unknown function (DUF2712)
HPPHLOHB_04266 4.1e-125
HPPHLOHB_04267 9e-122
HPPHLOHB_04268 2e-127 S Protein of unknown function (DUF2705)
HPPHLOHB_04269 2.6e-115 V ATPases associated with a variety of cellular activities
HPPHLOHB_04270 6.2e-132
HPPHLOHB_04271 5.9e-67 yybH S SnoaL-like domain
HPPHLOHB_04272 3e-124 yybG S Pentapeptide repeat-containing protein
HPPHLOHB_04273 3.2e-220 ynfM EGP Major facilitator Superfamily
HPPHLOHB_04274 2.1e-165 yybE K Transcriptional regulator
HPPHLOHB_04275 2e-79 yjcF S Acetyltransferase (GNAT) domain
HPPHLOHB_04276 2.7e-77 yybC
HPPHLOHB_04277 3e-127 S Metallo-beta-lactamase superfamily
HPPHLOHB_04278 5.6e-77 yybA 2.3.1.57 K transcriptional
HPPHLOHB_04279 5.9e-79 yjcF S Acetyltransferase (GNAT) domain
HPPHLOHB_04280 1.5e-101 yyaS S Membrane
HPPHLOHB_04281 5.4e-100 yyaR K Acetyltransferase (GNAT) domain
HPPHLOHB_04282 5.4e-67 yyaQ S YjbR
HPPHLOHB_04283 1.7e-107 yyaP 1.5.1.3 H RibD C-terminal domain
HPPHLOHB_04284 1.7e-249 tetL EGP Major facilitator Superfamily
HPPHLOHB_04285 9.7e-44 yyaL O Highly conserved protein containing a thioredoxin domain
HPPHLOHB_04286 5.1e-61 yyaN K MerR HTH family regulatory protein
HPPHLOHB_04287 3.3e-161 yyaM EG EamA-like transporter family
HPPHLOHB_04288 0.0 yyaL O COG1331 Highly conserved protein containing a thioredoxin domain
HPPHLOHB_04289 9.5e-169 yyaK S CAAX protease self-immunity
HPPHLOHB_04290 3.8e-246 EGP Major facilitator superfamily
HPPHLOHB_04291 5.1e-96 maa 2.3.1.79 S Bacterial transferase hexapeptide (six repeats)
HPPHLOHB_04292 4e-68 yyaH 4.4.1.5 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HPPHLOHB_04293 3.3e-180 ccpB 3.5.1.4, 5.1.1.1 K Transcriptional regulator
HPPHLOHB_04294 8.1e-145 xth 3.1.11.2 L exodeoxyribonuclease III
HPPHLOHB_04295 5.1e-37 rpsR J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HPPHLOHB_04296 2.9e-69 ssb L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
HPPHLOHB_04297 4.3e-46 rpsF J Binds together with S18 to 16S ribosomal RNA
HPPHLOHB_04298 4e-201 ychF J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
HPPHLOHB_04299 0.0 yyaE C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HPPHLOHB_04300 2.3e-33 yyzM S protein conserved in bacteria
HPPHLOHB_04301 8.1e-177 yyaD S Membrane
HPPHLOHB_04302 1.6e-111 yyaC S Sporulation protein YyaC
HPPHLOHB_04303 2.1e-149 spo0J K Belongs to the ParB family
HPPHLOHB_04304 2.2e-134 soj D COG1192 ATPases involved in chromosome partitioning
HPPHLOHB_04305 1.5e-74 S Bacterial PH domain
HPPHLOHB_04306 1.9e-150 noc D Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage
HPPHLOHB_04307 2.2e-131 rsmG 2.1.1.170 J Specifically methylates the N7 position of guanine in position 535 of 16S rRNA
HPPHLOHB_04308 0.0 gidA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
HPPHLOHB_04309 3.1e-251 mnmE S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPPHLOHB_04310 6.5e-108 jag S single-stranded nucleic acid binding R3H
HPPHLOHB_04311 1.7e-118 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HPPHLOHB_04312 3e-54 rnpA 3.1.26.5 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme

eggNOG-mapper v2 (Database: eggNOG v5.0, Jul. 2018 release)