ORF_ID e_value Gene_name EC_number CAZy COGs Description
MEDLAEOO_00001 9.7e-46 oppA E ABC transporter substrate-binding protein
MEDLAEOO_00002 5.6e-132 oppC P Binding-protein-dependent transport system inner membrane component
MEDLAEOO_00003 2.6e-172 oppB P ABC transporter permease
MEDLAEOO_00004 1.5e-170 oppF P Belongs to the ABC transporter superfamily
MEDLAEOO_00005 1.1e-192 oppD P Belongs to the ABC transporter superfamily
MEDLAEOO_00006 4.9e-35 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
MEDLAEOO_00007 3.7e-182 plsX 2.3.1.15 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
MEDLAEOO_00008 0.0 recG 3.6.4.12 L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MEDLAEOO_00009 7.6e-305 yloV S DAK2 domain fusion protein YloV
MEDLAEOO_00010 4e-57 asp S Asp23 family, cell envelope-related function
MEDLAEOO_00011 1.4e-26 rpmB J Belongs to the bacterial ribosomal protein bL28 family
MEDLAEOO_00012 2.6e-91 S N-acetylmuramoyl-L-alanine amidase activity
MEDLAEOO_00013 4.5e-30 S Bacteriophage holin of superfamily 6 (Holin_LLH)
MEDLAEOO_00019 1e-06 S Domain of unknown function (DUF2479)
MEDLAEOO_00021 1.8e-135 S Phage minor structural protein
MEDLAEOO_00022 6.3e-36 S phage tail
MEDLAEOO_00023 3.9e-131 M Phage tail tape measure protein TP901
MEDLAEOO_00026 2.4e-13 S Pfam:Phage_TTP_1
MEDLAEOO_00028 8.6e-14 S Bacteriophage HK97-gp10, putative tail-component
MEDLAEOO_00030 5.2e-17 S Phage gp6-like head-tail connector protein
MEDLAEOO_00031 3.8e-54 S Phage capsid family
MEDLAEOO_00032 1.8e-85 clpP 3.4.21.92 OU Belongs to the peptidase S14 family
MEDLAEOO_00033 4.5e-134 S Phage portal protein
MEDLAEOO_00035 6.2e-279 S Phage Terminase
MEDLAEOO_00038 9.9e-58 S Phage terminase, small subunit
MEDLAEOO_00039 3.5e-49 L HNH nucleases
MEDLAEOO_00041 3.1e-14 arpU S Phage transcriptional regulator, ArpU family
MEDLAEOO_00042 9.8e-12
MEDLAEOO_00044 3.3e-37 S VRR_NUC
MEDLAEOO_00055 2.7e-268 S Phage plasmid primase, P4
MEDLAEOO_00056 1.9e-29 S Protein of unknown function (DUF669)
MEDLAEOO_00057 1.1e-147 res L Helicase C-terminal domain protein
MEDLAEOO_00059 1.6e-70 S AAA domain
MEDLAEOO_00065 3.5e-46
MEDLAEOO_00066 4.4e-79 S Phage antirepressor protein KilAC domain
MEDLAEOO_00067 4.7e-18 K Helix-turn-helix XRE-family like proteins
MEDLAEOO_00069 2.2e-15 E Pfam:DUF955
MEDLAEOO_00071 9.9e-118 L Belongs to the 'phage' integrase family
MEDLAEOO_00072 1.4e-30
MEDLAEOO_00073 4.1e-124 thiN 2.7.6.2 H thiamine pyrophosphokinase
MEDLAEOO_00074 2.9e-119 rpe 5.1.3.1 G Belongs to the ribulose-phosphate 3-epimerase family
MEDLAEOO_00075 4.5e-163 rsgA 3.1.3.100 S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
MEDLAEOO_00076 0.0 prkC 2.7.11.1 KLT serine threonine protein kinase
MEDLAEOO_00077 1.1e-138 stp 3.1.3.16 T phosphatase
MEDLAEOO_00078 1.6e-244 sun 2.1.1.176 J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MEDLAEOO_00079 5.7e-172 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MEDLAEOO_00080 0.0 priA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MEDLAEOO_00081 1.1e-33 rpoZ 2.7.7.6 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
MEDLAEOO_00082 2.1e-111 gmk 2.7.4.8, 4.1.1.23 F Essential for recycling GMP and indirectly, cGMP
MEDLAEOO_00083 1.1e-77 6.3.3.2 S ASCH
MEDLAEOO_00084 2.6e-300 recN L May be involved in recombinational repair of damaged DNA
MEDLAEOO_00085 2.3e-153 rrmJ 2.1.1.226, 2.1.1.227 J Ribosomal RNA large subunit methyltransferase J
MEDLAEOO_00086 1e-159 ispA 2.5.1.1, 2.5.1.10, 2.5.1.29, 2.5.1.90 H Belongs to the FPP GGPP synthase family
MEDLAEOO_00087 3.7e-35 xseB 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
MEDLAEOO_00088 2.9e-193 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
MEDLAEOO_00089 6.7e-156 folD 1.5.1.5, 3.5.4.9 F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MEDLAEOO_00090 1.1e-63 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MEDLAEOO_00091 3.4e-71 yqhY S Asp23 family, cell envelope-related function
MEDLAEOO_00092 4.9e-102 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MEDLAEOO_00093 3e-196 pepP 3.4.11.9, 3.4.13.9 E Creatinase/Prolidase N-terminal domain
MEDLAEOO_00094 1.3e-47 rpmA J Belongs to the bacterial ribosomal protein bL27 family
MEDLAEOO_00095 5.8e-49 rplU J This protein binds to 23S rRNA in the presence of protein L20
MEDLAEOO_00096 3.7e-151 S Uncharacterised 5xTM membrane BCR, YitT family COG1284
MEDLAEOO_00097 7.8e-255 S Uncharacterized protein conserved in bacteria (DUF2325)
MEDLAEOO_00099 1.6e-27 dmpI 5.3.2.6 G Belongs to the 4-oxalocrotonate tautomerase family
MEDLAEOO_00100 4.3e-298 S Predicted membrane protein (DUF2207)
MEDLAEOO_00101 1.2e-155 cinI S Serine hydrolase (FSH1)
MEDLAEOO_00102 1.9e-204 M Glycosyl hydrolases family 25
MEDLAEOO_00104 8.5e-178 I Carboxylesterase family
MEDLAEOO_00105 1.5e-64 arsC 1.20.4.1 P Belongs to the ArsC family
MEDLAEOO_00106 2.9e-277 V ABC-type multidrug transport system, ATPase and permease components
MEDLAEOO_00107 4.5e-291 V ABC-type multidrug transport system, ATPase and permease components
MEDLAEOO_00108 1.3e-122 S haloacid dehalogenase-like hydrolase
MEDLAEOO_00111 6.7e-172 M Glycosyl hydrolases family 25
MEDLAEOO_00112 5e-29
MEDLAEOO_00113 7.9e-19
MEDLAEOO_00115 1.1e-07
MEDLAEOO_00116 1.1e-18 S Phage uncharacterised protein (Phage_XkdX)
MEDLAEOO_00117 1.3e-22
MEDLAEOO_00123 3.4e-35
MEDLAEOO_00124 8.5e-10
MEDLAEOO_00125 1.4e-114 Z012_12235 S Baseplate J-like protein
MEDLAEOO_00126 1.4e-30
MEDLAEOO_00127 9.2e-38
MEDLAEOO_00128 9.6e-102
MEDLAEOO_00129 2.3e-45
MEDLAEOO_00130 1.3e-59 M LysM domain
MEDLAEOO_00131 1.4e-195 M Phage tail tape measure protein TP901
MEDLAEOO_00132 1.1e-11
MEDLAEOO_00133 2.3e-11
MEDLAEOO_00134 2.9e-133 Z012_02110 S Protein of unknown function (DUF3383)
MEDLAEOO_00135 1.6e-27
MEDLAEOO_00136 1.5e-08
MEDLAEOO_00137 2e-42
MEDLAEOO_00138 1.9e-28 S Protein of unknown function (DUF4054)
MEDLAEOO_00139 2.6e-37 Z012_11565 S Uncharacterized protein conserved in bacteria (DUF2184)
MEDLAEOO_00140 1e-22
MEDLAEOO_00141 2.4e-50 S Uncharacterized protein conserved in bacteria (DUF2213)
MEDLAEOO_00142 1.6e-20 S Lysin motif
MEDLAEOO_00143 1.1e-54 S Phage Mu protein F like protein
MEDLAEOO_00144 2.5e-91 S Protein of unknown function (DUF1073)
MEDLAEOO_00145 9.6e-187 S Terminase-like family
MEDLAEOO_00148 1.1e-20 S N-methyltransferase activity
MEDLAEOO_00156 1e-10 S VRR_NUC
MEDLAEOO_00158 4e-69 S ORF6C domain
MEDLAEOO_00163 1.5e-21 radC L DNA repair protein
MEDLAEOO_00165 7.1e-29 K Helix-turn-helix domain
MEDLAEOO_00166 1.3e-43 S ERF superfamily
MEDLAEOO_00167 1.3e-53 S Protein of unknown function (DUF1351)
MEDLAEOO_00171 3.2e-10
MEDLAEOO_00174 6.6e-11 K Helix-turn-helix XRE-family like proteins
MEDLAEOO_00175 4.8e-17 S protein disulfide oxidoreductase activity
MEDLAEOO_00178 1.4e-95 sip L Belongs to the 'phage' integrase family
MEDLAEOO_00179 5.1e-12 S haloacid dehalogenase-like hydrolase
MEDLAEOO_00180 7e-50
MEDLAEOO_00181 1.9e-37
MEDLAEOO_00182 1.2e-63 S Alpha beta hydrolase
MEDLAEOO_00183 3.7e-19 S Alpha beta hydrolase
MEDLAEOO_00184 0.0 pepX 3.4.14.11 E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline
MEDLAEOO_00185 2.8e-81 msrB 1.8.4.11, 1.8.4.12 O peptide methionine sulfoxide reductase
MEDLAEOO_00186 7.1e-46
MEDLAEOO_00187 3.1e-148 glcU U sugar transport
MEDLAEOO_00188 1.9e-249 lctP C L-lactate permease
MEDLAEOO_00189 0.0 carB 6.3.5.5 F Carbamoyl-phosphate synthase
MEDLAEOO_00190 6.4e-212 carA 6.3.5.5 F Carbamoyl-phosphate synthetase glutamine chain
MEDLAEOO_00191 8.8e-245 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
MEDLAEOO_00192 1e-181 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
MEDLAEOO_00193 7.2e-95 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MEDLAEOO_00194 9.1e-167 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
MEDLAEOO_00195 1.6e-126 pyrF 4.1.1.23 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
MEDLAEOO_00196 1.9e-118 pyrE 2.4.2.10, 4.1.1.23 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MEDLAEOO_00197 1.5e-102 GM NmrA-like family
MEDLAEOO_00198 5.4e-68 L Transposase
MEDLAEOO_00199 3.7e-162 S SLAP domain
MEDLAEOO_00200 5.4e-121 ung2 3.2.2.27 L Uracil-DNA glycosylase
MEDLAEOO_00201 9.8e-146 E GDSL-like Lipase/Acylhydrolase family
MEDLAEOO_00202 2e-112 lexA 3.4.21.88 K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MEDLAEOO_00203 3e-38 ynzC S UPF0291 protein
MEDLAEOO_00204 5.5e-30 yneF S Uncharacterised protein family (UPF0154)
MEDLAEOO_00205 0.0 mdlA V ABC transporter
MEDLAEOO_00206 0.0 mdlB V ABC transporter
MEDLAEOO_00207 0.0 pepO 3.4.24.71 O Peptidase family M13
MEDLAEOO_00208 5.7e-222 cfa 2.1.1.317, 2.1.1.79 M cyclopropane-fatty-acyl-phospholipid synthase
MEDLAEOO_00209 2.9e-116 plsC 2.3.1.51 I Acyltransferase
MEDLAEOO_00210 3e-195 yabB 2.1.1.223 L Methyltransferase small domain
MEDLAEOO_00211 3.7e-137 rpsB J Belongs to the universal ribosomal protein uS2 family
MEDLAEOO_00212 3.1e-184 tsf J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MEDLAEOO_00213 1.4e-130 pyrH 2.7.4.22 F Catalyzes the reversible phosphorylation of UMP to UDP
MEDLAEOO_00214 5.3e-93 frr J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
MEDLAEOO_00215 5.4e-138 uppS 2.5.1.31 H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MEDLAEOO_00216 8.4e-140 cdsA 2.7.7.41 I Belongs to the CDS family
MEDLAEOO_00217 5.7e-196 rseP 3.4.21.107, 3.4.21.116 M zinc metalloprotease
MEDLAEOO_00218 0.0 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
MEDLAEOO_00219 0.0 polC 2.7.7.7 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MEDLAEOO_00220 2.5e-83 rimP J Required for maturation of 30S ribosomal subunits
MEDLAEOO_00221 1.4e-196 nusA K Participates in both transcription termination and antitermination
MEDLAEOO_00222 8.8e-47 ylxR K Protein of unknown function (DUF448)
MEDLAEOO_00223 3.2e-47 rplGA J ribosomal protein
MEDLAEOO_00224 0.0 infB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MEDLAEOO_00225 1.1e-59 rbfA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MEDLAEOO_00226 1.6e-155 truB 5.4.99.25 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MEDLAEOO_00227 3.2e-175 ribF 2.7.1.26, 2.7.7.2 H Belongs to the ribF family
MEDLAEOO_00228 4.9e-193 hrcA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
MEDLAEOO_00229 8e-68 grpE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MEDLAEOO_00230 0.0 dnaK O Heat shock 70 kDa protein
MEDLAEOO_00231 2.2e-202 dnaJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
MEDLAEOO_00232 0.0 lepA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
MEDLAEOO_00233 1.5e-102 srtA 3.4.22.70 M sortase family
MEDLAEOO_00234 0.0 recJ L Single-stranded-DNA-specific exonuclease RecJ
MEDLAEOO_00235 1.2e-94 apt 2.4.2.22, 2.4.2.7 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MEDLAEOO_00236 0.0 L PLD-like domain
MEDLAEOO_00237 4.8e-42 S SnoaL-like domain
MEDLAEOO_00238 5.4e-53 hipB K sequence-specific DNA binding
MEDLAEOO_00239 8e-22 rpiB 5.3.1.6 G Ribose/Galactose Isomerase
MEDLAEOO_00240 3.4e-27
MEDLAEOO_00241 1.7e-09 3.6.3.2, 3.6.3.6 P cation transport ATPase
MEDLAEOO_00242 1.2e-35 3.6.3.2, 3.6.3.6 P cation transport ATPase
MEDLAEOO_00243 2.5e-264 3.6.3.6 P Cation transporter/ATPase, N-terminus
MEDLAEOO_00244 1.9e-19
MEDLAEOO_00245 9.2e-262 emrY EGP Major facilitator Superfamily
MEDLAEOO_00246 8.8e-90 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MEDLAEOO_00247 7.6e-239 pyrP F Permease
MEDLAEOO_00248 1.9e-22 K Putative DNA-binding domain
MEDLAEOO_00249 1.9e-253 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
MEDLAEOO_00250 5.7e-69 rplI J Binds to the 23S rRNA
MEDLAEOO_00251 0.0 yybT T signaling protein consisting of a modified GGDEF domain and a DHH domain
MEDLAEOO_00252 7.4e-128 citG 2.4.2.52, 2.7.7.61 H 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase
MEDLAEOO_00253 4.5e-192 I transferase activity, transferring acyl groups other than amino-acyl groups
MEDLAEOO_00254 5.6e-179 S PFAM Archaeal ATPase
MEDLAEOO_00255 2.4e-73 S cog cog1373
MEDLAEOO_00256 8.6e-136 V ABC transporter transmembrane region
MEDLAEOO_00257 5.2e-170 degV S DegV family
MEDLAEOO_00258 3.3e-164 phnD P ABC transporter, phosphonate, periplasmic substrate-binding protein
MEDLAEOO_00259 2.3e-137 L transposase, IS605 OrfB family
MEDLAEOO_00260 2.1e-28 S Peptidase propeptide and YPEB domain
MEDLAEOO_00261 2.4e-60 ypaA S Protein of unknown function (DUF1304)
MEDLAEOO_00262 2.3e-309 oppA3 E ABC transporter, substratebinding protein
MEDLAEOO_00263 6.1e-269 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
MEDLAEOO_00264 1.2e-127 K LytTr DNA-binding domain
MEDLAEOO_00265 1.6e-132 2.7.13.3 T GHKL domain
MEDLAEOO_00266 1.8e-81 cas9 L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
MEDLAEOO_00267 3.7e-92 cas9 L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
MEDLAEOO_00268 3e-130 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MEDLAEOO_00269 8.3e-40 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MEDLAEOO_00270 4e-40 S CRISPR-associated protein (Cas_Csn2)
MEDLAEOO_00271 4e-08
MEDLAEOO_00272 6.6e-56
MEDLAEOO_00273 2.7e-57
MEDLAEOO_00274 1.6e-11
MEDLAEOO_00275 8.1e-126 S PAS domain
MEDLAEOO_00276 2e-310 E Amino acid permease
MEDLAEOO_00278 8.8e-82 M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MEDLAEOO_00279 2.2e-90 2.7.7.65 T GGDEF domain
MEDLAEOO_00280 8.2e-36
MEDLAEOO_00281 5.2e-112 ica2 GT2 M Glycosyl transferase family group 2
MEDLAEOO_00282 3.7e-26 queD 4.1.2.50, 4.2.3.12 H 6-pyruvoyl tetrahydropterin synthase
MEDLAEOO_00283 1.2e-92 yhjH 3.1.4.52 T Putative diguanylate phosphodiesterase
MEDLAEOO_00284 1e-149 D Alpha beta
MEDLAEOO_00285 1e-297 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
MEDLAEOO_00286 0.0 bglP 2.7.1.208, 2.7.1.211 G phosphotransferase system
MEDLAEOO_00287 1.8e-142 licT K CAT RNA binding domain
MEDLAEOO_00288 3.8e-207 glxK 2.7.1.165 G Belongs to the glycerate kinase type-1 family
MEDLAEOO_00289 7.4e-85 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MEDLAEOO_00290 1.6e-118
MEDLAEOO_00291 1.8e-75 K Penicillinase repressor
MEDLAEOO_00292 1.4e-147 S hydrolase
MEDLAEOO_00293 3.1e-256 glmM 5.4.2.10 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MEDLAEOO_00294 7.5e-172 ybbR S YbbR-like protein
MEDLAEOO_00295 6.4e-151 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MEDLAEOO_00296 7.3e-208 potD P ABC transporter
MEDLAEOO_00297 4.8e-127 potC P ABC transporter permease
MEDLAEOO_00298 1.3e-129 potB P ABC transporter permease
MEDLAEOO_00299 1.8e-206 potA 3.6.3.30, 3.6.3.31 P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
MEDLAEOO_00300 2e-163 murB 1.3.1.98 M Cell wall formation
MEDLAEOO_00301 4e-98 dnaQ 2.7.7.7 L DNA polymerase III
MEDLAEOO_00302 7e-86 ydiB 2.7.1.221, 5.1.1.1 O Hydrolase, P-loop family
MEDLAEOO_00303 4.1e-181 pta 2.3.1.8, 3.6.3.21 C phosphate acetyltransferase
MEDLAEOO_00304 9.7e-137 ung 3.2.2.27 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MEDLAEOO_00305 3.4e-155 ycsE S Sucrose-6F-phosphate phosphohydrolase
MEDLAEOO_00306 1.2e-94
MEDLAEOO_00307 6e-199 L COG2826 Transposase and inactivated derivatives, IS30 family
MEDLAEOO_00308 1.7e-142 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
MEDLAEOO_00309 1e-226 pgk 2.7.2.3, 5.3.1.1 F Belongs to the phosphoglycerate kinase family
MEDLAEOO_00310 6.5e-190 gap 1.2.1.12 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
MEDLAEOO_00311 3.3e-189 cggR K Putative sugar-binding domain
MEDLAEOO_00313 2.8e-290
MEDLAEOO_00314 4.6e-274 ycaM E amino acid
MEDLAEOO_00315 3.1e-48 S Domain of unknown function (DUF4811)
MEDLAEOO_00316 1.3e-224 lmrB EGP Major facilitator Superfamily
MEDLAEOO_00317 9.5e-22 lmrB EGP Major facilitator Superfamily
MEDLAEOO_00318 4.2e-77 K MerR HTH family regulatory protein
MEDLAEOO_00319 3.1e-139 S Cysteine-rich secretory protein family
MEDLAEOO_00320 7.5e-231 pbuG S permease
MEDLAEOO_00321 2.5e-119 K helix_turn_helix, mercury resistance
MEDLAEOO_00322 3.3e-37
MEDLAEOO_00323 9.6e-110 papP P ABC transporter, permease protein
MEDLAEOO_00324 2e-110 P ABC transporter permease
MEDLAEOO_00325 1.8e-133 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
MEDLAEOO_00326 3e-53 cjaA ET ABC transporter substrate-binding protein
MEDLAEOO_00327 8.1e-91 cjaA ET ABC transporter substrate-binding protein
MEDLAEOO_00331 2.6e-11 ssb L Single-strand binding protein family
MEDLAEOO_00333 4.8e-181 lacX 5.1.3.3 G Aldose 1-epimerase
MEDLAEOO_00334 1.4e-86 C Aldo keto reductase
MEDLAEOO_00335 3.8e-48 M LysM domain protein
MEDLAEOO_00336 2.9e-15 M LysM domain protein
MEDLAEOO_00337 3.9e-136 L Transposase and inactivated derivatives
MEDLAEOO_00339 7.7e-50 L PFAM IS66 Orf2 family protein
MEDLAEOO_00341 4.3e-24 S SLAP domain
MEDLAEOO_00342 7.6e-25 S SLAP domain
MEDLAEOO_00343 6.2e-76 S ABC-2 family transporter protein
MEDLAEOO_00344 4.7e-60 S ABC-2 family transporter protein
MEDLAEOO_00345 2.4e-92 V ABC transporter, ATP-binding protein
MEDLAEOO_00346 4.4e-151 S Metal-independent alpha-mannosidase (GH125)
MEDLAEOO_00347 3.8e-184 manA 5.3.1.8 G mannose-6-phosphate isomerase
MEDLAEOO_00348 1.4e-46
MEDLAEOO_00349 1.8e-131 sagD S YcaO cyclodehydratase, ATP-ad Mg2+-binding
MEDLAEOO_00351 5.6e-36
MEDLAEOO_00352 3.3e-183 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MEDLAEOO_00353 8.4e-125 luxT K Bacterial regulatory proteins, tetR family
MEDLAEOO_00354 2.8e-135
MEDLAEOO_00355 1.3e-258 glnPH2 P ABC transporter permease
MEDLAEOO_00356 2.6e-132 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
MEDLAEOO_00357 6.4e-224 S Cysteine-rich secretory protein family
MEDLAEOO_00358 1.2e-205 ddl 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
MEDLAEOO_00359 1.4e-112
MEDLAEOO_00360 2.2e-202 yibE S overlaps another CDS with the same product name
MEDLAEOO_00361 1.7e-129 yibF S overlaps another CDS with the same product name
MEDLAEOO_00362 1.1e-144 I alpha/beta hydrolase fold
MEDLAEOO_00363 0.0 G Belongs to the glycosyl hydrolase 31 family
MEDLAEOO_00364 1e-215 nagA 3.5.1.25 G Belongs to the metallo-dependent hydrolases superfamily. NagA family
MEDLAEOO_00365 1.5e-274 S Archaea bacterial proteins of unknown function
MEDLAEOO_00367 3.6e-90 ntd 2.4.2.6 F Nucleoside
MEDLAEOO_00368 3.9e-87 2.7.1.200, 2.7.1.202, 2.7.1.204 G Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
MEDLAEOO_00369 3.4e-149 ptp3 3.1.3.48 T Tyrosine phosphatase family
MEDLAEOO_00370 5.2e-84 uspA T universal stress protein
MEDLAEOO_00371 1e-149 phnD P Phosphonate ABC transporter
MEDLAEOO_00372 4.1e-136 phnC 3.6.3.28 P Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
MEDLAEOO_00373 1.2e-111 phnE 3.6.1.63 P Binding-protein-dependent transport system inner membrane component
MEDLAEOO_00374 2.2e-148 phnE 3.6.1.63 P Binding-protein-dependent transport system inner membrane component
MEDLAEOO_00375 3.3e-106 tag 3.2.2.20 L glycosylase
MEDLAEOO_00376 3.9e-84
MEDLAEOO_00377 1.7e-273 S Calcineurin-like phosphoesterase
MEDLAEOO_00378 0.0 asnB 6.3.5.4 E Asparagine synthase
MEDLAEOO_00379 5.6e-255 yxbA 6.3.1.12 S ATP-grasp enzyme
MEDLAEOO_00380 0.0 nrdD 1.1.98.6 F Ribonucleoside-triphosphate reductase
MEDLAEOO_00381 8.7e-141 nrdG 1.97.1.4 O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MEDLAEOO_00382 2.1e-103 S Iron-sulfur cluster assembly protein
MEDLAEOO_00383 1.5e-230 XK27_04775 S PAS domain
MEDLAEOO_00384 5.8e-112 L COG3547 Transposase and inactivated derivatives
MEDLAEOO_00385 2.3e-43 ybhL S Belongs to the BI1 family
MEDLAEOO_00386 1.2e-210 S Bacterial protein of unknown function (DUF871)
MEDLAEOO_00387 8.5e-279 cas9 L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
MEDLAEOO_00388 1e-30 S cog cog1373
MEDLAEOO_00389 7.6e-91 F Nucleoside 2-deoxyribosyltransferase
MEDLAEOO_00390 3.3e-261 gabD 1.2.1.16, 1.2.1.20, 1.2.1.79 C Belongs to the aldehyde dehydrogenase family
MEDLAEOO_00391 2.3e-101 L An automated process has identified a potential problem with this gene model
MEDLAEOO_00392 8.7e-26 dnaQ 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MEDLAEOO_00393 4e-60 L Resolvase, N terminal domain
MEDLAEOO_00394 0.0 ppsA 2.7.9.2 H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate
MEDLAEOO_00395 1.3e-133 hxlA 6.2.1.3 H Aldolase/RraA
MEDLAEOO_00396 1.5e-261 P Sodium:sulfate symporter transmembrane region
MEDLAEOO_00397 2.2e-151
MEDLAEOO_00398 3e-24
MEDLAEOO_00399 3.3e-86 bcgIB 2.1.1.72, 3.1.21.3 V Type I restriction modification DNA specificity domain
MEDLAEOO_00400 6.2e-143 V N-6 DNA Methylase
MEDLAEOO_00401 5.8e-85 2.3.1.128 K Acetyltransferase (GNAT) domain
MEDLAEOO_00402 2e-157 S reductase
MEDLAEOO_00403 9.3e-35
MEDLAEOO_00404 3.5e-71 yjaB 2.3.1.181 K Acetyltransferase (GNAT) domain
MEDLAEOO_00405 5e-19 mepA V MATE efflux family protein
MEDLAEOO_00406 2.4e-179 mepA V MATE efflux family protein
MEDLAEOO_00407 4.1e-17 L transposase and inactivated derivatives, IS30 family
MEDLAEOO_00408 2.2e-165 L Transposase and inactivated derivatives, IS30 family
MEDLAEOO_00412 1.9e-19 L Replication initiation factor
MEDLAEOO_00413 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MEDLAEOO_00414 9.3e-74 nrdI F NrdI Flavodoxin like
MEDLAEOO_00415 3.6e-193 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MEDLAEOO_00416 1.1e-109 tnpR1 L Resolvase, N terminal domain
MEDLAEOO_00417 4.7e-70 L IS1381, transposase OrfA
MEDLAEOO_00418 1.1e-76 L PFAM transposase, IS204 IS1001 IS1096 IS1165 family protein
MEDLAEOO_00419 1.3e-28
MEDLAEOO_00420 1.7e-142 soj D AAA domain
MEDLAEOO_00421 1.9e-166 repA S Replication initiator protein A
MEDLAEOO_00422 8.5e-128 S Fic/DOC family
MEDLAEOO_00423 5.4e-60 L Resolvase, N-terminal
MEDLAEOO_00424 1.6e-166 L Putative transposase DNA-binding domain
MEDLAEOO_00425 3.8e-160 hepT 2.5.1.30, 2.5.1.90 H Belongs to the FPP GGPP synthase family
MEDLAEOO_00426 1.1e-161 menA 2.5.1.74 H 1,4-dihydroxy-2-naphthoate
MEDLAEOO_00427 2.4e-231 ndh 1.6.99.3 C NADH dehydrogenase
MEDLAEOO_00428 6.2e-43 1.3.5.4 C FAD binding domain
MEDLAEOO_00429 2.3e-84 3.6.4.12 S PD-(D/E)XK nuclease family transposase
MEDLAEOO_00430 2.8e-168 K LysR substrate binding domain
MEDLAEOO_00431 1.1e-121 3.6.1.27 I Acid phosphatase homologues
MEDLAEOO_00432 0.0 leuS 6.1.1.4 J Belongs to the class-I aminoacyl-tRNA synthetase family
MEDLAEOO_00433 2.4e-274 ytgP S Polysaccharide biosynthesis protein
MEDLAEOO_00434 6.3e-192 oppA E ABC transporter, substratebinding protein
MEDLAEOO_00435 1.3e-30
MEDLAEOO_00436 4.2e-145 pstS P Phosphate
MEDLAEOO_00437 1.1e-159 pstC P probably responsible for the translocation of the substrate across the membrane
MEDLAEOO_00438 1.2e-152 pstA P Phosphate transport system permease protein PstA
MEDLAEOO_00439 1.3e-139 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
MEDLAEOO_00440 1.4e-105 phoU P Plays a role in the regulation of phosphate uptake
MEDLAEOO_00441 9.5e-121 T Transcriptional regulatory protein, C terminal
MEDLAEOO_00442 1e-280 phoR 2.7.13.3 T Histidine kinase
MEDLAEOO_00443 0.0 pepO 3.4.24.71 O Peptidase family M13
MEDLAEOO_00444 1.3e-30
MEDLAEOO_00445 3.6e-69 T Toxin-antitoxin system, toxin component, MazF family
MEDLAEOO_00446 3.7e-102 L Integrase
MEDLAEOO_00447 3.9e-113 L PFAM Integrase catalytic
MEDLAEOO_00448 2e-57 clcA P chloride
MEDLAEOO_00450 5.2e-104
MEDLAEOO_00452 7.8e-140 glpF U Belongs to the MIP aquaporin (TC 1.A.8) family
MEDLAEOO_00453 7.5e-103 G Phosphoglycerate mutase family
MEDLAEOO_00454 7.8e-52 V ABC-type multidrug transport system, ATPase and permease components
MEDLAEOO_00455 2.6e-275 V ABC-type multidrug transport system, ATPase and permease components
MEDLAEOO_00456 2.9e-174 L Bifunctional protein
MEDLAEOO_00457 1.3e-149 oppA E ABC transporter substrate-binding protein
MEDLAEOO_00458 8.5e-54 oppA E ABC transporter substrate-binding protein
MEDLAEOO_00460 3.8e-139 pnuC H nicotinamide mononucleotide transporter
MEDLAEOO_00461 4.3e-75
MEDLAEOO_00462 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MEDLAEOO_00463 1.3e-168 dnaI L Primosomal protein DnaI
MEDLAEOO_00464 5.1e-251 dnaB L Replication initiation and membrane attachment
MEDLAEOO_00465 3.5e-82 nrdR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MEDLAEOO_00466 1.3e-105 coaE 2.7.1.24 F Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MEDLAEOO_00467 4.2e-155 fpg 3.2.2.23, 4.2.99.18 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
MEDLAEOO_00468 0.0 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MEDLAEOO_00469 3.5e-25 qmcA O prohibitin homologues
MEDLAEOO_00470 7.4e-105 qmcA O prohibitin homologues
MEDLAEOO_00471 8e-51 L RelB antitoxin
MEDLAEOO_00472 4.5e-188 S Bacteriocin helveticin-J
MEDLAEOO_00473 4.4e-283 M Peptidase family M1 domain
MEDLAEOO_00474 1.8e-176 S SLAP domain
MEDLAEOO_00475 6.9e-218 mepA V MATE efflux family protein
MEDLAEOO_00476 9.7e-247 mpl 6.3.2.4, 6.3.2.45, 6.3.2.8 M Belongs to the MurCDEF family
MEDLAEOO_00477 1.7e-122 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
MEDLAEOO_00478 2.8e-54 ytpP 2.7.1.180, 5.3.4.1 CO Thioredoxin
MEDLAEOO_00480 3.3e-126 trmB 2.1.1.297, 2.1.1.33 J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
MEDLAEOO_00481 6.5e-221 ecsB U ABC transporter
MEDLAEOO_00482 5.7e-135 ecsA V ABC transporter, ATP-binding protein
MEDLAEOO_00483 8.3e-78 hit FG Scavenger mRNA decapping enzyme C-term binding
MEDLAEOO_00484 3.9e-25
MEDLAEOO_00485 4.3e-153 prsA 5.2.1.8 M Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins
MEDLAEOO_00486 1.9e-72 eda 4.1.2.14, 4.1.3.42 G KDPG and KHG aldolase
MEDLAEOO_00487 1.1e-265
MEDLAEOO_00488 2.4e-51 S Domain of unknown function DUF1829
MEDLAEOO_00489 2.9e-23
MEDLAEOO_00490 1.9e-186 cbf S Metal dependent phosphohydrolases with conserved 'HD' motif.
MEDLAEOO_00491 0.0 L AAA domain
MEDLAEOO_00492 1e-226 yhaO L Ser Thr phosphatase family protein
MEDLAEOO_00493 7.2e-56 yheA S Belongs to the UPF0342 family
MEDLAEOO_00494 0.0 pbp2A 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
MEDLAEOO_00495 4.2e-150 rluA 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
MEDLAEOO_00496 1.4e-94
MEDLAEOO_00497 3e-112 L PFAM transposase IS116 IS110 IS902
MEDLAEOO_00498 1.3e-167 scrK 2.7.1.2, 2.7.1.4 GK ROK family
MEDLAEOO_00500 1.4e-16
MEDLAEOO_00501 2.6e-51 L PFAM RNA-directed DNA polymerase (Reverse transcriptase)
MEDLAEOO_00502 2.2e-113 S SLAP domain
MEDLAEOO_00503 3e-270 L Transposase DDE domain
MEDLAEOO_00504 9.7e-231 potE E amino acid
MEDLAEOO_00505 8.8e-41 clcA P chloride
MEDLAEOO_00506 1.6e-60 clcA P chloride
MEDLAEOO_00507 4.7e-26 K FCD
MEDLAEOO_00508 1.4e-98 L Helix-turn-helix domain
MEDLAEOO_00509 9.6e-184 L DDE superfamily endonuclease
MEDLAEOO_00510 1e-210 yttB EGP Major facilitator Superfamily
MEDLAEOO_00511 3.6e-88 nagA 3.5.1.25 G Belongs to the metallo-dependent hydrolases superfamily. NagA family
MEDLAEOO_00512 7.7e-10 nagA 3.5.1.25 G Belongs to the metallo-dependent hydrolases superfamily. NagA family
MEDLAEOO_00513 2.9e-109 nanE 5.1.3.9 G Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
MEDLAEOO_00514 4.8e-15 axe1 3.1.1.41 Q Acetyl xylan esterase (AXE1)
MEDLAEOO_00515 1.1e-59 axe1 3.1.1.41 Q Acetyl xylan esterase (AXE1)
MEDLAEOO_00516 1e-220 nanT E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MEDLAEOO_00517 1.9e-121 napA P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
MEDLAEOO_00518 2.3e-56 G Xylose isomerase domain protein TIM barrel
MEDLAEOO_00519 8.4e-90 nanK GK ROK family
MEDLAEOO_00520 2.9e-122 nanA 4.1.3.3, 4.3.3.7 EM Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate
MEDLAEOO_00521 3.7e-66 K Helix-turn-helix domain, rpiR family
MEDLAEOO_00522 7.1e-263 E ABC transporter, substratebinding protein
MEDLAEOO_00523 9.1e-10 K peptidyl-tyrosine sulfation
MEDLAEOO_00525 1.2e-128 S interspecies interaction between organisms
MEDLAEOO_00526 2.7e-34
MEDLAEOO_00529 1.9e-21
MEDLAEOO_00530 6e-148
MEDLAEOO_00531 6.7e-170
MEDLAEOO_00532 2e-263 glnA 6.3.1.2 E glutamine synthetase
MEDLAEOO_00533 7.6e-225 ynbB 4.4.1.1 P aluminum resistance
MEDLAEOO_00534 1.5e-167 miaA 2.5.1.75 F Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MEDLAEOO_00535 1.5e-65 yqhL P Rhodanese-like protein
MEDLAEOO_00536 9.7e-36 yqgQ S Bacterial protein of unknown function (DUF910)
MEDLAEOO_00537 4e-119 gluP 3.4.21.105 S Rhomboid family
MEDLAEOO_00538 2.7e-97 ygfA 6.3.3.2 H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MEDLAEOO_00539 1.2e-20 rpmG J Belongs to the bacterial ribosomal protein bL33 family
MEDLAEOO_00540 0.0 pbp2b 3.4.16.4 M Penicillin-binding Protein
MEDLAEOO_00541 0.0 S membrane
MEDLAEOO_00542 5.2e-170 2.7.1.59 G BadF/BadG/BcrA/BcrD ATPase family
MEDLAEOO_00543 1.3e-38 S RelB antitoxin
MEDLAEOO_00544 3.4e-51 S Bacterial toxin of type II toxin-antitoxin system, YafQ
MEDLAEOO_00545 6.7e-44 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
MEDLAEOO_00546 6.7e-139 fhuC 3.6.3.34 HP abc transporter atp-binding protein
MEDLAEOO_00547 9.5e-148 isdF U Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MEDLAEOO_00548 8.7e-159 isdE P Periplasmic binding protein
MEDLAEOO_00549 6.3e-123 M Iron Transport-associated domain
MEDLAEOO_00550 3e-09 isdH M Iron Transport-associated domain
MEDLAEOO_00551 2.2e-89
MEDLAEOO_00552 5.8e-100 L Helix-turn-helix domain
MEDLAEOO_00554 8.2e-179 yvdE K helix_turn _helix lactose operon repressor
MEDLAEOO_00555 4.1e-36 ptp2 3.1.3.48 T Tyrosine phosphatase family
MEDLAEOO_00556 4.1e-33 adh 1.1.1.1, 1.1.1.14 E alcohol dehydrogenase
MEDLAEOO_00557 7.4e-49 S Peptidase propeptide and YPEB domain
MEDLAEOO_00558 6.8e-226 I Protein of unknown function (DUF2974)
MEDLAEOO_00559 2.3e-184 S Uncharacterised protein family (UPF0236)
MEDLAEOO_00561 4.6e-88 ymdB S Macro domain protein
MEDLAEOO_00564 1.2e-47 L Transposase, IS116 IS110 IS902 family
MEDLAEOO_00565 2e-39 S Transglycosylase associated protein
MEDLAEOO_00566 3.1e-150 xerD L Phage integrase, N-terminal SAM-like domain
MEDLAEOO_00567 3e-66 crcB U Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MEDLAEOO_00568 1e-63 crcB U Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MEDLAEOO_00569 5e-13 mmuM 1.5.1.20, 2.1.1.10 H homocysteine S-methyltransferase
MEDLAEOO_00570 1.4e-115 mmuP E amino acid
MEDLAEOO_00571 1.4e-272 pepV 3.5.1.18 E dipeptidase PepV
MEDLAEOO_00572 6.3e-93 XK26_02160 C Pyridoxamine 5'-phosphate oxidase
MEDLAEOO_00573 1.7e-284 E Amino acid permease
MEDLAEOO_00574 0.0 yaaO 4.1.1.17, 4.1.1.19 E Orn/Lys/Arg decarboxylase, C-terminal domain
MEDLAEOO_00575 6.7e-245 ynbB 4.4.1.1 P aluminum resistance
MEDLAEOO_00576 0.0 recQ 3.6.4.12 L ATP-dependent DNA helicase RecQ
MEDLAEOO_00577 1.3e-81 C Flavodoxin
MEDLAEOO_00578 0.0 uvrA3 L excinuclease ABC, A subunit
MEDLAEOO_00579 4.1e-189 mmuM 1.5.1.20, 2.1.1.10 H homocysteine S-methyltransferase
MEDLAEOO_00580 4.7e-114 3.6.1.27 I Acid phosphatase homologues
MEDLAEOO_00581 4.1e-80 yvbK 3.1.3.25 K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
MEDLAEOO_00582 1.4e-115 lacA 2.3.1.79 S Transferase hexapeptide repeat
MEDLAEOO_00583 1.2e-203 pbpX1 V Beta-lactamase
MEDLAEOO_00584 1.1e-99 pdxK 2.7.1.35 H Phosphomethylpyrimidine kinase
MEDLAEOO_00585 7.5e-95 S ECF-type riboflavin transporter, S component
MEDLAEOO_00586 4.4e-230 S Putative peptidoglycan binding domain
MEDLAEOO_00587 1.1e-83 K Acetyltransferase (GNAT) domain
MEDLAEOO_00588 1.4e-209 pepT2 3.4.11.14, 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
MEDLAEOO_00589 1.6e-12 pepT2 3.4.11.14, 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
MEDLAEOO_00590 7.3e-191 yrvN L AAA C-terminal domain
MEDLAEOO_00591 2.8e-64 spxA_2 1.20.4.1 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
MEDLAEOO_00592 8.3e-167 treB G phosphotransferase system
MEDLAEOO_00593 4.5e-111 treB G phosphotransferase system
MEDLAEOO_00594 4.4e-100 treR K UTRA
MEDLAEOO_00595 2.9e-288 treC 3.2.1.93 GH13 G Alpha amylase, catalytic domain protein
MEDLAEOO_00596 1.3e-17
MEDLAEOO_00597 2.4e-49
MEDLAEOO_00598 6.4e-88 yoaK S Protein of unknown function (DUF1275)
MEDLAEOO_00599 5.3e-17 yoaK S Protein of unknown function (DUF1275)
MEDLAEOO_00600 3.6e-111 ltrA S Bacterial low temperature requirement A protein (LtrA)
MEDLAEOO_00601 3.8e-143 L Transposase DDE domain
MEDLAEOO_00602 2.7e-152 mdtG EGP Major facilitator Superfamily
MEDLAEOO_00603 3.5e-70 yebR 1.8.4.14 T GAF domain-containing protein
MEDLAEOO_00605 1.6e-08
MEDLAEOO_00606 7.8e-79 cpsF M Oligosaccharide biosynthesis protein Alg14 like
MEDLAEOO_00607 7.2e-158 M Glycosyltransferase
MEDLAEOO_00608 5.9e-120 rfbP M Bacterial sugar transferase
MEDLAEOO_00609 3.7e-145 ywqE 3.1.3.48 GM PHP domain protein
MEDLAEOO_00610 2.6e-122 ywqD 2.7.10.1 D Capsular exopolysaccharide family
MEDLAEOO_00611 3.6e-144 epsB M biosynthesis protein
MEDLAEOO_00612 3.8e-177 brpA K Cell envelope-like function transcriptional attenuator common domain protein
MEDLAEOO_00614 1.7e-29 S Predicted membrane protein (DUF2335)
MEDLAEOO_00616 5.5e-215 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MEDLAEOO_00617 3.5e-175 S Cysteine-rich secretory protein family
MEDLAEOO_00618 1.6e-41
MEDLAEOO_00619 2.6e-118 M NlpC/P60 family
MEDLAEOO_00620 1.4e-136 M NlpC P60 family protein
MEDLAEOO_00621 5e-88 M NlpC/P60 family
MEDLAEOO_00622 2.2e-88 gmk2 2.7.4.8 F Guanylate kinase homologues.
MEDLAEOO_00623 4.2e-28
MEDLAEOO_00624 2.9e-279 S O-antigen ligase like membrane protein
MEDLAEOO_00625 3.3e-112
MEDLAEOO_00626 4.7e-221 tnpB L Putative transposase DNA-binding domain
MEDLAEOO_00627 5.5e-77 nrdI F NrdI Flavodoxin like
MEDLAEOO_00628 9.9e-177 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MEDLAEOO_00629 2.5e-68
MEDLAEOO_00630 9.1e-112 yvpB S Peptidase_C39 like family
MEDLAEOO_00631 1.1e-83 S Threonine/Serine exporter, ThrE
MEDLAEOO_00632 2.4e-136 thrE S Putative threonine/serine exporter
MEDLAEOO_00633 8.9e-292 S ABC transporter
MEDLAEOO_00634 8.3e-58
MEDLAEOO_00635 5e-72 rimL J Acetyltransferase (GNAT) domain
MEDLAEOO_00636 1.4e-34
MEDLAEOO_00637 1.2e-30
MEDLAEOO_00638 1.8e-111 S Protein of unknown function (DUF554)
MEDLAEOO_00639 8.7e-197 brpA K Cell envelope-like function transcriptional attenuator common domain protein
MEDLAEOO_00640 0.0 pepF E oligoendopeptidase F
MEDLAEOO_00641 2.9e-31
MEDLAEOO_00642 1.3e-69 doc S Prophage maintenance system killer protein
MEDLAEOO_00645 4.6e-27 S Enterocin A Immunity
MEDLAEOO_00646 1.7e-22 blpT
MEDLAEOO_00652 5e-78 K Putative DNA-binding domain
MEDLAEOO_00653 1.1e-183 scrR K helix_turn _helix lactose operon repressor
MEDLAEOO_00654 3.7e-295 scrB 3.2.1.26 GH32 G invertase
MEDLAEOO_00655 0.0 scrA 2.7.1.208, 2.7.1.211, 5.3.1.1 G phosphotransferase system
MEDLAEOO_00656 2.3e-181 M CHAP domain
MEDLAEOO_00657 3.5e-75
MEDLAEOO_00658 1.4e-41 groS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MEDLAEOO_00659 5.9e-294 groL O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
MEDLAEOO_00660 0.0 mutS L that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MEDLAEOO_00661 0.0 mutL L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MEDLAEOO_00662 1.7e-102 ruvA 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
MEDLAEOO_00663 1.5e-186 ruvB 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
MEDLAEOO_00664 9.6e-41 yajC U Preprotein translocase
MEDLAEOO_00665 9.6e-288 zwf 1.1.1.363, 1.1.1.49 G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MEDLAEOO_00666 1.7e-215 dinB 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MEDLAEOO_00667 1.4e-181 nrnA 3.1.13.3, 3.1.3.7 S DHHA1 domain protein
MEDLAEOO_00668 2e-226 cshB 3.6.4.13 JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
MEDLAEOO_00669 0.0 alaS 6.1.1.7 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MEDLAEOO_00670 2e-42 yrzL S Belongs to the UPF0297 family
MEDLAEOO_00671 6.1e-73 yqgF J Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MEDLAEOO_00672 1.1e-50 yrzB S Belongs to the UPF0473 family
MEDLAEOO_00673 0.0 mutS2 L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
MEDLAEOO_00674 3.5e-54 trxA O Belongs to the thioredoxin family
MEDLAEOO_00675 9.7e-59 mscL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
MEDLAEOO_00676 1.7e-69 yslB S Protein of unknown function (DUF2507)
MEDLAEOO_00677 2.5e-144 murI 3.6.1.66, 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
MEDLAEOO_00678 1.1e-110 rdgB 3.6.1.66, 5.1.1.3 F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MEDLAEOO_00679 7.7e-30 ropB K Helix-turn-helix domain
MEDLAEOO_00680 1.2e-57 L Transposase
MEDLAEOO_00682 1.1e-59 L An automated process has identified a potential problem with this gene model
MEDLAEOO_00683 1.6e-08
MEDLAEOO_00684 1.4e-83 K FR47-like protein
MEDLAEOO_00685 1.1e-297 lysS 6.1.1.6 J Belongs to the class-II aminoacyl-tRNA synthetase family
MEDLAEOO_00686 2e-194 dus J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MEDLAEOO_00687 3.3e-166 hslO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MEDLAEOO_00688 0.0 ftsH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MEDLAEOO_00689 3.4e-241 tilS 2.4.2.8, 6.3.4.19 J Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
MEDLAEOO_00690 6.3e-63 yabR J S1 RNA binding domain
MEDLAEOO_00691 6.8e-60 divIC D Septum formation initiator
MEDLAEOO_00692 1.6e-33 yabO J S4 domain protein
MEDLAEOO_00693 0.0 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MEDLAEOO_00694 5.1e-104 pth 3.1.1.29 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
MEDLAEOO_00695 1.5e-183 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
MEDLAEOO_00696 9.9e-129 S (CBS) domain
MEDLAEOO_00697 1.7e-215 alr 5.1.1.1 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MEDLAEOO_00698 1.7e-60 acpS 2.7.6.3, 2.7.8.7, 5.1.1.1 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
MEDLAEOO_00699 4.8e-250 cshA 3.6.4.13 F DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
MEDLAEOO_00700 8e-260 murF 6.3.2.10, 6.3.2.13 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
MEDLAEOO_00701 2.5e-39 rpmE2 J Ribosomal protein L31
MEDLAEOO_00702 0.0 dexB 3.2.1.10, 3.2.1.70 GH13 G Alpha amylase, catalytic domain protein
MEDLAEOO_00703 3.8e-156 S Sucrose-6F-phosphate phosphohydrolase
MEDLAEOO_00704 1.3e-298 ybeC E amino acid
MEDLAEOO_00705 7e-231 glyA 2.1.2.1 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MEDLAEOO_00706 3.8e-42
MEDLAEOO_00707 2.8e-52
MEDLAEOO_00708 1.4e-184 5.3.3.2 C FMN-dependent dehydrogenase
MEDLAEOO_00709 1.2e-141 yfeO P Voltage gated chloride channel
MEDLAEOO_00710 1.9e-53 L Transposase and inactivated derivatives
MEDLAEOO_00712 3.7e-27 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MEDLAEOO_00713 4.4e-101 ylbE GM NAD(P)H-binding
MEDLAEOO_00714 7.6e-94 S VanZ like family
MEDLAEOO_00715 8.9e-133 yebC K Transcriptional regulatory protein
MEDLAEOO_00716 1.7e-179 comGA NU Type II IV secretion system protein
MEDLAEOO_00717 1.7e-171 comGB NU type II secretion system
MEDLAEOO_00718 3.1e-43 comGC U competence protein ComGC
MEDLAEOO_00719 1.8e-69
MEDLAEOO_00720 2.3e-41
MEDLAEOO_00721 3.8e-77 comGF U Putative Competence protein ComGF
MEDLAEOO_00722 1.6e-21
MEDLAEOO_00723 1.9e-186 ytxK 2.1.1.72 L N-6 DNA Methylase
MEDLAEOO_00724 6.3e-221 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MEDLAEOO_00726 2.5e-89 M Protein of unknown function (DUF3737)
MEDLAEOO_00727 9.9e-227 patB 4.4.1.8 E Aminotransferase, class I
MEDLAEOO_00728 7.2e-191 manA 5.3.1.8 G mannose-6-phosphate isomerase
MEDLAEOO_00729 7.7e-67 S SdpI/YhfL protein family
MEDLAEOO_00730 7.5e-132 K Transcriptional regulatory protein, C terminal
MEDLAEOO_00731 7.2e-267 yclK 2.7.13.3, 4.6.1.1 T Histidine kinase
MEDLAEOO_00732 0.0 ltaS 2.7.8.20 M Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
MEDLAEOO_00733 1.1e-104 vanZ V VanZ like family
MEDLAEOO_00734 3.2e-253 pgi 5.3.1.9 G Belongs to the GPI family
MEDLAEOO_00735 4.9e-217 EGP Major facilitator Superfamily
MEDLAEOO_00736 1.7e-195 ampC V Beta-lactamase
MEDLAEOO_00739 1.7e-262 murF 6.3.2.10, 6.3.2.13 M Domain of unknown function (DUF1727)
MEDLAEOO_00740 1.7e-113 tdk 2.7.1.21 F thymidine kinase
MEDLAEOO_00741 3.1e-182 prfA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MEDLAEOO_00742 7.3e-155 prmB 2.1.1.297, 2.1.1.298 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
MEDLAEOO_00743 1.9e-189 ywlC 2.7.7.87, 3.1.3.48 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
MEDLAEOO_00744 6.8e-113 upp 2.4.2.9 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MEDLAEOO_00745 1e-128 atpB C it plays a direct role in the translocation of protons across the membrane
MEDLAEOO_00746 3.5e-27 atpE C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MEDLAEOO_00747 4.4e-46 atpF C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MEDLAEOO_00748 1.3e-91 atpH C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MEDLAEOO_00749 2.5e-283 atpA 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MEDLAEOO_00750 8.9e-173 atpG C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MEDLAEOO_00751 3.3e-240 atpD 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MEDLAEOO_00752 9e-72 atpC C Produces ATP from ADP in the presence of a proton gradient across the membrane
MEDLAEOO_00753 2e-30 ywzB S Protein of unknown function (DUF1146)
MEDLAEOO_00754 1.2e-177 mbl D Cell shape determining protein MreB Mrl
MEDLAEOO_00755 1e-50 yidD S Could be involved in insertion of integral membrane proteins into the membrane
MEDLAEOO_00756 3.3e-33 S Protein of unknown function (DUF2969)
MEDLAEOO_00757 4.7e-216 rodA D Belongs to the SEDS family
MEDLAEOO_00758 1.8e-78 usp6 T universal stress protein
MEDLAEOO_00759 8.4e-39
MEDLAEOO_00760 6.3e-238 rarA L recombination factor protein RarA
MEDLAEOO_00761 1.3e-84 yueI S Protein of unknown function (DUF1694)
MEDLAEOO_00762 1.4e-110 rpsD J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MEDLAEOO_00763 2.1e-294 ezrA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
MEDLAEOO_00764 6.2e-213 iscS2 2.8.1.7 E Aminotransferase class V
MEDLAEOO_00765 2e-225 thiI 2.8.1.4 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MEDLAEOO_00766 1.7e-184 3.6.4.12 K Putative ATP-dependent DNA helicase recG C-terminal
MEDLAEOO_00767 3.2e-119 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
MEDLAEOO_00768 5.5e-44 3.6.4.12 S PD-(D/E)XK nuclease family transposase
MEDLAEOO_00769 2.1e-65 2.4.1.83 GT2 S GtrA-like protein
MEDLAEOO_00770 5.2e-170 yfdH 2.4.2.53 GT2 M Glycosyltransferase, group 2 family protein
MEDLAEOO_00771 1.5e-94 S Protein of unknown function (DUF3990)
MEDLAEOO_00772 6.5e-44
MEDLAEOO_00774 0.0 3.6.3.8 P P-type ATPase
MEDLAEOO_00775 1.1e-132 S AAA domain, putative AbiEii toxin, Type IV TA system
MEDLAEOO_00776 2.5e-52
MEDLAEOO_00777 0.0 valS 6.1.1.9 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
MEDLAEOO_00778 1.5e-239 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
MEDLAEOO_00779 5.7e-126 S Haloacid dehalogenase-like hydrolase
MEDLAEOO_00780 2.3e-108 radC L DNA repair protein
MEDLAEOO_00781 2.4e-176 mreB D cell shape determining protein MreB
MEDLAEOO_00782 2e-147 mreC M Involved in formation and maintenance of cell shape
MEDLAEOO_00783 2.7e-94 mreD
MEDLAEOO_00785 6.4e-54 S Protein of unknown function (DUF3397)
MEDLAEOO_00786 6.3e-78 mraZ K Belongs to the MraZ family
MEDLAEOO_00787 7.2e-175 rsmH 2.1.1.199 J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
MEDLAEOO_00788 1.8e-54 ftsL D Cell division protein FtsL
MEDLAEOO_00789 0.0 ftsI 3.4.16.4 M Penicillin-binding Protein
MEDLAEOO_00790 1.5e-175 mraY 2.7.8.13 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MEDLAEOO_00791 5e-262 murD 6.3.2.9 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MEDLAEOO_00792 3.7e-207 murG 2.4.1.227, 6.3.2.8 GT28 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MEDLAEOO_00793 4.5e-152 divIB D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
MEDLAEOO_00794 1.3e-246 ftsA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
MEDLAEOO_00795 1.7e-206 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MEDLAEOO_00796 7.3e-74 sepF D Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
MEDLAEOO_00797 1.7e-45 yggT S YGGT family
MEDLAEOO_00798 5.7e-149 ylmH S S4 domain protein
MEDLAEOO_00799 2.8e-74 gpsB D DivIVA domain protein
MEDLAEOO_00800 0.0 ileS 6.1.1.5 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MEDLAEOO_00801 3.6e-31 cspA K 'Cold-shock' DNA-binding domain
MEDLAEOO_00802 2.8e-102 nudF 3.6.1.13 L ADP-ribose pyrophosphatase
MEDLAEOO_00803 6.7e-37
MEDLAEOO_00804 1.2e-126 mtnN 3.2.2.9 E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MEDLAEOO_00805 3.2e-217 iscS 2.8.1.7 E Aminotransferase class V
MEDLAEOO_00806 5.4e-56 XK27_04120 S Putative amino acid metabolism
MEDLAEOO_00807 5.1e-220 mnmA 2.8.1.13 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
MEDLAEOO_00808 3.9e-127 pgm6 5.4.2.11, 5.4.2.12 G Phosphoglycerate mutase family
MEDLAEOO_00809 8.3e-106 S Repeat protein
MEDLAEOO_00810 0.0 recD2 3.1.11.5 L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
MEDLAEOO_00811 1e-293 L Nuclease-related domain
MEDLAEOO_00812 2.3e-164 ytlR 2.7.1.91 I Diacylglycerol kinase catalytic domain
MEDLAEOO_00813 1.1e-223 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MEDLAEOO_00814 3.3e-275 yjeM E Amino Acid
MEDLAEOO_00815 5.8e-83 S Fic/DOC family
MEDLAEOO_00816 3.1e-278
MEDLAEOO_00817 3.2e-77
MEDLAEOO_00818 2.3e-87 S Protein of unknown function (DUF805)
MEDLAEOO_00819 5.6e-68 O OsmC-like protein
MEDLAEOO_00820 9.4e-209 EGP Major facilitator Superfamily
MEDLAEOO_00821 2.5e-215 sptS 2.7.13.3 T Histidine kinase
MEDLAEOO_00822 1.3e-139 L Transposase and inactivated derivatives, IS30 family
MEDLAEOO_00823 3.7e-32 L Transposase and inactivated derivatives, IS30 family
MEDLAEOO_00824 6.4e-71 scrR K Periplasmic binding protein domain
MEDLAEOO_00825 5.5e-36
MEDLAEOO_00826 2e-196 galM 5.1.3.3 G Catalyzes the interconversion of alpha and beta anomers of maltose
MEDLAEOO_00827 1.1e-288 galT 2.7.7.12 G UDP-glucose--hexose-1-phosphate uridylyltransferase
MEDLAEOO_00828 2.1e-221 galK 2.7.1.6 F Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MEDLAEOO_00829 0.0 lacZ 3.2.1.23 G -beta-galactosidase
MEDLAEOO_00830 0.0 lacS G Transporter
MEDLAEOO_00831 3.2e-165 lacR K Transcriptional regulator
MEDLAEOO_00832 0.0 lacL 3.2.1.23 G Belongs to the glycosyl hydrolase 2 family
MEDLAEOO_00833 7e-146 lacM 3.2.1.23, 3.2.1.35, 3.2.1.51, 3.2.1.97 GH101,GH29 G beta-galactosidase
MEDLAEOO_00834 5.3e-189 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
MEDLAEOO_00835 7.6e-163 S Nucleotidyl transferase AbiEii toxin, Type IV TA system
MEDLAEOO_00836 2e-106 K Transcriptional regulator, AbiEi antitoxin
MEDLAEOO_00837 1.2e-188 K Periplasmic binding protein-like domain
MEDLAEOO_00841 2.5e-186 manL 2.7.1.191 G PTS system sorbose subfamily IIB component
MEDLAEOO_00842 1.7e-129 manY G PTS system
MEDLAEOO_00843 1e-173 manN G system, mannose fructose sorbose family IID component
MEDLAEOO_00844 1.1e-62 manO S Domain of unknown function (DUF956)
MEDLAEOO_00845 3.3e-158 K Transcriptional regulator
MEDLAEOO_00846 1.3e-85 maa S transferase hexapeptide repeat
MEDLAEOO_00847 2.6e-242 cycA E Amino acid permease
MEDLAEOO_00848 7.6e-49 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
MEDLAEOO_00849 0.0 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
MEDLAEOO_00850 0.0 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
MEDLAEOO_00851 0.0 mtlR K Mga helix-turn-helix domain
MEDLAEOO_00852 0.0 mtlA 2.7.1.197 G PTS system, Lactose/Cellobiose specific IIB subunit
MEDLAEOO_00853 2.1e-79 mtlF 2.7.1.197 G catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
MEDLAEOO_00854 1e-218 mtlD 1.1.1.17 C mannitol-1-phosphate 5-dehydrogenase activity
MEDLAEOO_00855 3.2e-28 4.1.1.44 S Carboxymuconolactone decarboxylase family
MEDLAEOO_00856 2.3e-78 4.1.1.44 S Carboxymuconolactone decarboxylase family
MEDLAEOO_00857 2.1e-32
MEDLAEOO_00858 3.7e-59 apfA 2.7.7.72, 3.6.1.61 F Nudix hydrolase
MEDLAEOO_00859 2.3e-156 K Helix-turn-helix XRE-family like proteins
MEDLAEOO_00860 3.9e-298 V ABC transporter transmembrane region
MEDLAEOO_00861 0.0 pckA 4.1.1.49 H Phosphoenolpyruvate carboxykinase
MEDLAEOO_00862 1.7e-193 S TerB-C domain
MEDLAEOO_00863 8.4e-25 G Peptidase_C39 like family
MEDLAEOO_00864 2.8e-162 M NlpC/P60 family
MEDLAEOO_00865 6.5e-91 G Peptidase_C39 like family
MEDLAEOO_00866 1.8e-175 pepI 3.4.11.5, 3.5.1.101 E Releases the N-terminal proline from various substrates
MEDLAEOO_00867 2.8e-77 P Cobalt transport protein
MEDLAEOO_00868 4.8e-249 cbiO1 S ABC transporter, ATP-binding protein
MEDLAEOO_00869 7.9e-174 K helix_turn_helix, arabinose operon control protein
MEDLAEOO_00870 8.3e-157 htpX O Belongs to the peptidase M48B family
MEDLAEOO_00871 5.1e-96 lemA S LemA family
MEDLAEOO_00872 7.5e-192 ybiR P Citrate transporter
MEDLAEOO_00873 2e-70 S Iron-sulphur cluster biosynthesis
MEDLAEOO_00874 1.9e-309 glpQ 3.1.4.46 C Membrane domain of glycerophosphoryl diester phosphodiesterase
MEDLAEOO_00875 1.2e-17
MEDLAEOO_00876 1.1e-07 S Uncharacterised protein family (UPF0236)
MEDLAEOO_00877 4.5e-189 ydaM M Glycosyl transferase
MEDLAEOO_00878 4e-177 G Glycosyl hydrolases family 8
MEDLAEOO_00879 1e-119 yfbR S HD containing hydrolase-like enzyme
MEDLAEOO_00880 6.4e-159 L HNH nucleases
MEDLAEOO_00881 7.3e-148 S Protein of unknown function (DUF805)
MEDLAEOO_00882 3.4e-135 glnQ E ABC transporter, ATP-binding protein
MEDLAEOO_00883 6.7e-290 glnP P ABC transporter permease
MEDLAEOO_00884 4e-121 mpg 3.2.2.21 L Belongs to the DNA glycosylase MPG family
MEDLAEOO_00885 5.8e-64 yeaO S Protein of unknown function, DUF488
MEDLAEOO_00886 1.3e-124 terC P Integral membrane protein TerC family
MEDLAEOO_00887 9.2e-92 ogt 2.1.1.63 L 6-O-methylguanine DNA methyltransferase, DNA binding domain
MEDLAEOO_00888 8.5e-133 cobB K SIR2 family
MEDLAEOO_00889 1.4e-69 def2 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins
MEDLAEOO_00890 5.1e-226 N Uncharacterized conserved protein (DUF2075)
MEDLAEOO_00891 4.8e-205 pbpX1 V Beta-lactamase
MEDLAEOO_00892 0.0 L Helicase C-terminal domain protein
MEDLAEOO_00893 3.8e-221 L Helicase C-terminal domain protein
MEDLAEOO_00894 1.3e-273 E amino acid
MEDLAEOO_00895 1.8e-158 xth 3.1.11.2 L exodeoxyribonuclease III
MEDLAEOO_00898 1.2e-191 ldhA 1.1.1.28 C Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MEDLAEOO_00899 3e-80 birA 6.3.4.15 H Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
MEDLAEOO_00900 1.9e-122 fabI 1.3.1.10, 1.3.1.9 I Enoyl- acyl-carrier-protein reductase NADH
MEDLAEOO_00901 1.1e-128 accA 2.1.3.15, 6.4.1.2 I alpha subunit
MEDLAEOO_00902 3.3e-139 accD 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MEDLAEOO_00903 9.6e-237 accC 6.3.4.14, 6.4.1.2 I Acetyl-CoA carboxylase biotin carboxylase subunit
MEDLAEOO_00904 9.2e-61 fabZ 3.5.1.108, 4.2.1.59 I FabA-like domain
MEDLAEOO_00905 2.2e-49 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
MEDLAEOO_00906 4e-210 fabF 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
MEDLAEOO_00907 2.9e-107 IQ reductase
MEDLAEOO_00908 1.7e-139 fabD 2.3.1.39 I Malonyl CoA-acyl carrier protein transacylase
MEDLAEOO_00909 2.1e-30 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
MEDLAEOO_00910 2.9e-38 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MEDLAEOO_00911 1.1e-86 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MEDLAEOO_00912 1.3e-48 4.2.1.59 I 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MEDLAEOO_00913 1.6e-73 marR K Transcriptional regulator, MarR family
MEDLAEOO_00914 1.5e-80
MEDLAEOO_00915 1.1e-163 L An automated process has identified a potential problem with this gene model
MEDLAEOO_00917 1.6e-25 K Helix-turn-helix XRE-family like proteins
MEDLAEOO_00918 1.2e-11
MEDLAEOO_00919 1.5e-216 2.1.1.14 E methionine synthase, vitamin-B12 independent
MEDLAEOO_00920 6.7e-89 luxS 4.4.1.21 H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
MEDLAEOO_00921 2e-264 lctP C L-lactate permease
MEDLAEOO_00922 5e-129 znuB U ABC 3 transport family
MEDLAEOO_00923 1.6e-117 fhuC P ABC transporter
MEDLAEOO_00924 1.6e-147 psaA P Belongs to the bacterial solute-binding protein 9 family
MEDLAEOO_00925 5.4e-41 K helix_turn_helix, Arsenical Resistance Operon Repressor
MEDLAEOO_00926 0.0 fruA 2.7.1.202, 2.7.1.204 GT Phosphotransferase System
MEDLAEOO_00927 2.2e-168 pfkB 2.7.1.11, 2.7.1.56 H Belongs to the carbohydrate kinase PfkB family. LacC subfamily
MEDLAEOO_00928 1.8e-136 fruR K DeoR C terminal sensor domain
MEDLAEOO_00929 1.8e-218 natB CP ABC-2 family transporter protein
MEDLAEOO_00930 1.1e-164 natA S ABC transporter, ATP-binding protein
MEDLAEOO_00931 1.7e-67
MEDLAEOO_00932 2e-23
MEDLAEOO_00933 8.2e-31 yozG K Transcriptional regulator
MEDLAEOO_00934 1.6e-49
MEDLAEOO_00935 7.5e-24
MEDLAEOO_00936 3e-21
MEDLAEOO_00940 2.2e-129 blpT
MEDLAEOO_00941 1.4e-107 M Transport protein ComB
MEDLAEOO_00942 9.3e-116 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
MEDLAEOO_00943 4.1e-101 ptp2 3.1.3.48 T Tyrosine phosphatase family
MEDLAEOO_00944 5.1e-292 glpK 2.7.1.30 F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MEDLAEOO_00945 1.5e-144 thiD 2.5.1.3, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Phosphomethylpyrimidine kinase
MEDLAEOO_00946 1.7e-184 G Transmembrane secretion effector
MEDLAEOO_00947 6.1e-136 V ABC transporter transmembrane region
MEDLAEOO_00948 2.9e-224 L transposase, IS605 OrfB family
MEDLAEOO_00949 1.1e-75 V ABC transporter transmembrane region
MEDLAEOO_00950 6.5e-64 L RelB antitoxin
MEDLAEOO_00951 2.1e-131 cobQ S glutamine amidotransferase
MEDLAEOO_00952 1.8e-81 M NlpC/P60 family
MEDLAEOO_00955 2.6e-155
MEDLAEOO_00956 7.8e-38
MEDLAEOO_00957 2e-32
MEDLAEOO_00958 6.2e-163 EG EamA-like transporter family
MEDLAEOO_00959 5e-165 EG EamA-like transporter family
MEDLAEOO_00960 4.6e-139 yicL EG EamA-like transporter family
MEDLAEOO_00961 4.3e-107
MEDLAEOO_00962 1.1e-110
MEDLAEOO_00963 5.8e-186 XK27_05540 S DUF218 domain
MEDLAEOO_00964 9.3e-264 yheS_2 S ATPases associated with a variety of cellular activities
MEDLAEOO_00965 4.7e-85
MEDLAEOO_00966 3.9e-57
MEDLAEOO_00967 4.7e-25 S Protein conserved in bacteria
MEDLAEOO_00968 1.3e-54 S protein encoded in hypervariable junctions of pilus gene clusters
MEDLAEOO_00969 7.7e-29 hicA S HicA toxin of bacterial toxin-antitoxin,
MEDLAEOO_00970 1.2e-40 ftsZ M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
MEDLAEOO_00971 1.2e-232 oppA E ABC transporter substrate-binding protein
MEDLAEOO_00972 2.1e-95 oppA E ABC transporter substrate-binding protein
MEDLAEOO_00973 3.2e-176 K AI-2E family transporter
MEDLAEOO_00974 2.6e-103 3.1.1.5 E GDSL-like Lipase/Acylhydrolase
MEDLAEOO_00975 4.1e-18
MEDLAEOO_00976 4.1e-245 G Major Facilitator
MEDLAEOO_00977 1.3e-79 E Zn peptidase
MEDLAEOO_00978 1e-41 ps115 K Helix-turn-helix XRE-family like proteins
MEDLAEOO_00979 5.6e-45
MEDLAEOO_00980 4.5e-66 S Bacteriocin helveticin-J
MEDLAEOO_00981 1.7e-66 S SLAP domain
MEDLAEOO_00982 5.8e-45
MEDLAEOO_00983 2.4e-136 XK27_08845 S ABC transporter, ATP-binding protein
MEDLAEOO_00984 5.6e-121 XK27_08840 U Belongs to the binding-protein-dependent transport system permease family
MEDLAEOO_00985 1.7e-174 ABC-SBP S ABC transporter
MEDLAEOO_00986 5.6e-132 yjjG 3.1.3.102, 3.1.3.104, 3.1.3.5, 3.8.1.2 S Haloacid dehalogenase-like hydrolase
MEDLAEOO_00987 1.6e-48 P CorA-like Mg2+ transporter protein
MEDLAEOO_00988 5.2e-75 P CorA-like Mg2+ transporter protein
MEDLAEOO_00989 3.5e-160 yvgN C Aldo keto reductase
MEDLAEOO_00990 0.0 tetP J elongation factor G
MEDLAEOO_00991 4e-150 3.1.3.102, 3.1.3.104 S haloacid dehalogenase-like hydrolase
MEDLAEOO_00992 1.2e-134 EGP Major facilitator Superfamily
MEDLAEOO_00994 0.0 fhaB M Rib/alpha-like repeat
MEDLAEOO_00995 0.0 malL 3.2.1.10, 3.2.1.20 GH13,GH31 G Alpha amylase, catalytic domain
MEDLAEOO_00996 0.0 nplT 3.2.1.133, 3.2.1.135, 3.2.1.54 GH13 G Belongs to the glycosyl hydrolase 13 family
MEDLAEOO_00997 0.0 map2 2.4.1.8 GH65 G hydrolase, family 65, central catalytic
MEDLAEOO_00998 9e-116 pgmB 2.4.1.64, 3.1.3.12, 3.2.1.28, 5.4.2.6 GH37,GH65 S beta-phosphoglucomutase
MEDLAEOO_00999 1.2e-208 msmX P Belongs to the ABC transporter superfamily
MEDLAEOO_01000 1.3e-213 malE G Bacterial extracellular solute-binding protein
MEDLAEOO_01001 1.1e-250 malF P Binding-protein-dependent transport system inner membrane component
MEDLAEOO_01002 3.3e-147 malG P ABC transporter permease
MEDLAEOO_01003 4.3e-67 K Helix-turn-helix XRE-family like proteins
MEDLAEOO_01006 4.8e-28
MEDLAEOO_01008 1.5e-36
MEDLAEOO_01009 9.5e-289 P ABC transporter
MEDLAEOO_01010 2.4e-284 V ABC-type multidrug transport system, ATPase and permease components
MEDLAEOO_01011 1.9e-248 yifK E Amino acid permease
MEDLAEOO_01012 9.1e-178 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MEDLAEOO_01013 8.5e-90 folA 1.5.1.3 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MEDLAEOO_01014 0.0 aha1 P E1-E2 ATPase
MEDLAEOO_01015 1.9e-175 F DNA/RNA non-specific endonuclease
MEDLAEOO_01016 2e-160 metQ2 P Belongs to the nlpA lipoprotein family
MEDLAEOO_01017 1e-190 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MEDLAEOO_01018 2e-73 metI P ABC transporter permease
MEDLAEOO_01019 9e-267 fumC 4.2.1.2 C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
MEDLAEOO_01020 1.9e-261 frdC 1.3.5.4 C FAD binding domain
MEDLAEOO_01021 3.1e-170 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
MEDLAEOO_01022 3.5e-252 pepC 3.4.22.40 E Peptidase C1-like family
MEDLAEOO_01023 6.2e-276 gnd 1.1.1.343, 1.1.1.44 H Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MEDLAEOO_01024 9.5e-31
MEDLAEOO_01025 0.0 poxB 1.2.3.3, 1.2.5.1 EH Belongs to the TPP enzyme family
MEDLAEOO_01026 0.0 gidA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
MEDLAEOO_01027 2.1e-252 mnmE S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MEDLAEOO_01028 1.2e-144 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
MEDLAEOO_01029 2.7e-61 rnpA 3.1.26.5 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
MEDLAEOO_01030 1.1e-15 rpmH J Belongs to the bacterial ribosomal protein bL34 family
MEDLAEOO_01031 1.6e-244 dnaA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MEDLAEOO_01032 4.2e-182 dnaN 2.7.7.7 L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
MEDLAEOO_01033 2.6e-35 yaaA S S4 domain protein YaaA
MEDLAEOO_01034 1.1e-209 recF L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MEDLAEOO_01035 0.0 gyrB 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MEDLAEOO_01036 0.0 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MEDLAEOO_01037 9.4e-49 rpsF J Binds together with S18 to 16S ribosomal RNA
MEDLAEOO_01038 4.5e-78 ssb L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
MEDLAEOO_01039 1.2e-35 rpsR J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MEDLAEOO_01040 8.2e-230 pbuG S permease
MEDLAEOO_01041 8.2e-140 cof S haloacid dehalogenase-like hydrolase
MEDLAEOO_01042 9.4e-72
MEDLAEOO_01043 9.3e-124 dgk 2.7.1.74, 2.7.1.76 F deoxynucleoside kinase
MEDLAEOO_01044 8.5e-119 dak 2.7.1.74, 2.7.1.76 F deoxynucleoside kinase
MEDLAEOO_01045 2.1e-134 nagB 3.1.1.31, 3.5.99.6 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
MEDLAEOO_01046 3.7e-159 yeaE S Aldo/keto reductase family
MEDLAEOO_01047 4.4e-172 yufQ S Belongs to the binding-protein-dependent transport system permease family
MEDLAEOO_01048 1.9e-198 yufP S Belongs to the binding-protein-dependent transport system permease family
MEDLAEOO_01049 1.3e-282 xylG 3.6.3.17 S ABC transporter
MEDLAEOO_01050 6.9e-181 tcsA S ABC transporter substrate-binding protein PnrA-like
MEDLAEOO_01051 3.9e-201 tcsA S ABC transporter substrate-binding protein PnrA-like
MEDLAEOO_01052 2.8e-100 S ECF transporter, substrate-specific component
MEDLAEOO_01053 0.0 ppc 4.1.1.31 H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MEDLAEOO_01054 0.0 macB_3 V ABC transporter, ATP-binding protein
MEDLAEOO_01055 1.6e-194 S DUF218 domain
MEDLAEOO_01056 2.7e-120 S CAAX protease self-immunity
MEDLAEOO_01057 3e-111 ropB K Transcriptional regulator
MEDLAEOO_01058 4.2e-154 EGP Major facilitator Superfamily
MEDLAEOO_01059 5.4e-51
MEDLAEOO_01060 2.6e-155 mutR K Helix-turn-helix XRE-family like proteins
MEDLAEOO_01061 4.1e-276 V ABC transporter transmembrane region
MEDLAEOO_01062 2.3e-41 S YoeB-like toxin of bacterial type II toxin-antitoxin system
MEDLAEOO_01063 1.9e-47 yefM 2.3.1.15 D Antitoxin component of a toxin-antitoxin (TA) module
MEDLAEOO_01064 2.8e-205 napA P Sodium/hydrogen exchanger family
MEDLAEOO_01065 0.0 cadA P P-type ATPase
MEDLAEOO_01066 1.5e-80 ykuL S (CBS) domain
MEDLAEOO_01067 1e-207 ywhK S Membrane
MEDLAEOO_01068 4.1e-44
MEDLAEOO_01069 5.2e-19 S D-Ala-teichoic acid biosynthesis protein
MEDLAEOO_01070 2.2e-287 dltA 6.1.1.13 H Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MEDLAEOO_01071 4.6e-238 dltB M MBOAT, membrane-bound O-acyltransferase family
MEDLAEOO_01072 1.7e-35 dltC 6.1.1.13 J Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MEDLAEOO_01073 1.5e-247 dltD M Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MEDLAEOO_01074 7.6e-177 pbpX2 V Beta-lactamase
MEDLAEOO_01075 2.3e-133 S Protein of unknown function (DUF975)
MEDLAEOO_01076 2.7e-137 lysA2 M Glycosyl hydrolases family 25
MEDLAEOO_01077 7.9e-291 ytgP S Polysaccharide biosynthesis protein
MEDLAEOO_01078 1.9e-36
MEDLAEOO_01079 0.0 XK27_06780 V ABC transporter permease
MEDLAEOO_01080 5.1e-125 XK27_06785 V ABC transporter, ATP-binding protein
MEDLAEOO_01081 2.2e-238 pts13C G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
MEDLAEOO_01082 2.2e-165 S Alpha/beta hydrolase of unknown function (DUF915)
MEDLAEOO_01083 0.0 clpE O AAA domain (Cdc48 subfamily)
MEDLAEOO_01084 4.3e-115 lepB 3.4.21.89 U Belongs to the peptidase S26 family
MEDLAEOO_01085 9.7e-234 cycA E Amino acid permease
MEDLAEOO_01086 9.2e-248 yifK E Amino acid permease
MEDLAEOO_01087 6.4e-135 S PFAM Archaeal ATPase
MEDLAEOO_01088 2.4e-172 V HNH endonuclease
MEDLAEOO_01090 2.2e-139 puuD S peptidase C26
MEDLAEOO_01091 1.8e-230 steT_1 E amino acid
MEDLAEOO_01092 3.2e-189 asnA 6.3.1.1 F aspartate--ammonia ligase
MEDLAEOO_01093 3.9e-206 4.2.1.126 S Bacterial protein of unknown function (DUF871)
MEDLAEOO_01096 7.7e-188 guaC 1.1.1.205, 1.7.1.7 F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
MEDLAEOO_01097 6.4e-251 purA 6.3.4.4 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MEDLAEOO_01098 6.2e-246 purB 4.3.2.2 F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MEDLAEOO_01099 3.5e-80 S AAA domain
MEDLAEOO_01100 1.2e-40 3.6.1.55 F NUDIX domain
MEDLAEOO_01101 1.6e-145 2.4.2.3 F Phosphorylase superfamily
MEDLAEOO_01102 2.2e-149 aacC 2.3.1.81 V Aminoglycoside 3-N-acetyltransferase
MEDLAEOO_01103 7.6e-100 yagE E Amino acid permease
MEDLAEOO_01104 5.6e-34 yagE E Amino acid permease
MEDLAEOO_01105 7.3e-86 3.4.21.96 S SLAP domain
MEDLAEOO_01106 7.9e-160 ypjC S Uncharacterised 5xTM membrane BCR, YitT family COG1284
MEDLAEOO_01107 1.2e-224 cca 2.7.7.19, 2.7.7.72 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
MEDLAEOO_01108 1.2e-107 hlyIII S protein, hemolysin III
MEDLAEOO_01109 2e-144 DegV S Uncharacterised protein, DegV family COG1307
MEDLAEOO_01110 7.1e-36 yozE S Belongs to the UPF0346 family
MEDLAEOO_01111 1e-67 yjcE P NhaP-type Na H and K H
MEDLAEOO_01112 4.4e-68 yjcE P Sodium proton antiporter
MEDLAEOO_01113 2.6e-76 yjcE P Sodium proton antiporter
MEDLAEOO_01114 2.8e-154 ylqF S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MEDLAEOO_01115 4.6e-132 rnhB 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MEDLAEOO_01116 5.8e-152 dprA LU DNA protecting protein DprA
MEDLAEOO_01117 0.0 topA 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MEDLAEOO_01118 1.4e-248 trmFO 2.1.1.74 J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
MEDLAEOO_01119 5e-141 xerC D Phage integrase, N-terminal SAM-like domain
MEDLAEOO_01120 1.9e-89 hslV 3.4.25.2 O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MEDLAEOO_01121 8.2e-236 hslU O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MEDLAEOO_01122 2.3e-159 degV S EDD domain protein, DegV family
MEDLAEOO_01123 1.1e-66
MEDLAEOO_01124 0.0 FbpA K Fibronectin-binding protein
MEDLAEOO_01125 0.0 carB1 6.3.5.5 F Carbamoyl-phosphate synthase
MEDLAEOO_01126 7.9e-199 carA 6.3.5.5 F Carbamoyl-phosphate synthetase glutamine chain
MEDLAEOO_01127 4.3e-169 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
MEDLAEOO_01128 2.8e-79 lspA 3.4.23.36 MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MEDLAEOO_01129 2.6e-281 fhs 6.3.4.3 F Belongs to the formate--tetrahydrofolate ligase family
MEDLAEOO_01130 5.5e-53
MEDLAEOO_01131 2.6e-105 psd 4.1.1.65 I Belongs to the phosphatidylserine decarboxylase family
MEDLAEOO_01133 1.4e-67 S Sel1-like repeats.
MEDLAEOO_01134 1.6e-97 3.1.4.37 S AAA domain
MEDLAEOO_01135 6.6e-182
MEDLAEOO_01136 1.2e-32
MEDLAEOO_01137 8.5e-78 S HIRAN
MEDLAEOO_01138 1.6e-51 3.6.4.12 L DNA helicase
MEDLAEOO_01139 2.3e-120 S AAA domain, putative AbiEii toxin, Type IV TA system
MEDLAEOO_01140 3.6e-183 L Phage integrase family
MEDLAEOO_01141 1.5e-65 rpsI J Belongs to the universal ribosomal protein uS9 family
MEDLAEOO_01142 5.9e-79 rplM J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MEDLAEOO_01143 3e-150 truA 5.4.99.12 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
MEDLAEOO_01144 1.3e-137 ecfT U Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MEDLAEOO_01145 2.1e-157 ecfA 3.6.3.55 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MEDLAEOO_01146 3.7e-154 ecfA1 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MEDLAEOO_01147 5.3e-60 rplQ J Ribosomal protein L17
MEDLAEOO_01148 1.1e-170 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MEDLAEOO_01149 3e-63 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MEDLAEOO_01150 4.2e-56 rpsM J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MEDLAEOO_01151 7.8e-15 rpmJ J Belongs to the bacterial ribosomal protein bL36 family
MEDLAEOO_01152 8.4e-34 infA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MEDLAEOO_01153 3.5e-120 adk 2.7.4.3 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
MEDLAEOO_01154 1.4e-237 secY U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
MEDLAEOO_01155 1.3e-70 rplO J Binds to the 23S rRNA
MEDLAEOO_01156 2.3e-24 rpmD J Ribosomal protein L30
MEDLAEOO_01157 4.1e-84 rpsE J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MEDLAEOO_01158 3.6e-55 rplR J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MEDLAEOO_01159 3.3e-92 rplF J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MEDLAEOO_01160 3.2e-68 rpsH J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MEDLAEOO_01161 8.9e-29 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MEDLAEOO_01162 5.5e-95 rplE J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MEDLAEOO_01163 3.4e-33 rplX J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MEDLAEOO_01164 2.5e-59 rplN J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MEDLAEOO_01165 5e-41 rpsQ J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MEDLAEOO_01166 1.3e-25 rpmC J Belongs to the universal ribosomal protein uL29 family
MEDLAEOO_01167 2.1e-76 rplP J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MEDLAEOO_01168 2.7e-120 rpsC J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MEDLAEOO_01169 4e-54 rplV J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MEDLAEOO_01170 1.1e-46 rpsS J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MEDLAEOO_01171 3.6e-154 rplB J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MEDLAEOO_01172 3.1e-47 rplW J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
MEDLAEOO_01173 2.1e-106 rplD J Forms part of the polypeptide exit tunnel
MEDLAEOO_01174 9e-113 rplC J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MEDLAEOO_01175 4.4e-49 rpsJ J Involved in the binding of tRNA to the ribosomes
MEDLAEOO_01176 1.8e-163
MEDLAEOO_01177 7.8e-26 K Acetyltransferase (GNAT) domain
MEDLAEOO_01179 0.0 ydgH S MMPL family
MEDLAEOO_01180 6.6e-99 yobS K Bacterial regulatory proteins, tetR family
MEDLAEOO_01181 3.3e-148 3.5.2.6 V Beta-lactamase enzyme family
MEDLAEOO_01182 1.8e-154 corA P CorA-like Mg2+ transporter protein
MEDLAEOO_01183 6.7e-240 G Bacterial extracellular solute-binding protein
MEDLAEOO_01184 9.2e-258 YSH1 S Zn-dependent metallo-hydrolase RNA specificity domain
MEDLAEOO_01185 6.1e-146 gtsC P Binding-protein-dependent transport system inner membrane component
MEDLAEOO_01186 1.6e-157 gtsB P ABC-type sugar transport systems, permease components
MEDLAEOO_01187 1.9e-203 malK P ATPases associated with a variety of cellular activities
MEDLAEOO_01188 1.3e-281 pipD E Dipeptidase
MEDLAEOO_01189 1.9e-158 endA F DNA RNA non-specific endonuclease
MEDLAEOO_01190 8e-182 dnaQ 2.7.7.7 L EXOIII
MEDLAEOO_01191 9e-158 K NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MEDLAEOO_01192 3e-116 yviA S Protein of unknown function (DUF421)
MEDLAEOO_01193 1.1e-56 S Protein of unknown function (DUF3290)
MEDLAEOO_01194 3.3e-183 pfkA 2.7.1.11 F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
MEDLAEOO_01195 0.0 pyk 2.7.1.40, 2.7.7.4 G Belongs to the pyruvate kinase family
MEDLAEOO_01196 1e-167 cvfB S S1 domain
MEDLAEOO_01197 2.9e-165 xerD D recombinase XerD
MEDLAEOO_01198 2.6e-61 ribT K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
MEDLAEOO_01199 7.6e-132 scpA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MEDLAEOO_01200 4.1e-104 scpB D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MEDLAEOO_01201 3.1e-130 rluB 5.4.99.19, 5.4.99.21, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
MEDLAEOO_01202 8.7e-114 U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
MEDLAEOO_01203 2.7e-18 M Lysin motif
MEDLAEOO_01204 2.2e-114 cmk 1.17.7.4, 2.5.1.19, 2.7.1.26, 2.7.4.25, 2.7.7.2, 6.3.2.1 F Belongs to the cytidylate kinase family. Type 1 subfamily
MEDLAEOO_01205 5.5e-212 rpsA 1.17.7.4 J Ribosomal protein S1
MEDLAEOO_01206 1.9e-247 der 1.1.1.399, 1.1.1.95 S GTPase that plays an essential role in the late steps of ribosome biogenesis
MEDLAEOO_01207 3e-41 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
MEDLAEOO_01208 1e-229 S Tetratricopeptide repeat protein
MEDLAEOO_01209 5.8e-288 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MEDLAEOO_01210 1e-282 V ABC transporter transmembrane region
MEDLAEOO_01211 5.2e-91 speG J Acetyltransferase (GNAT) domain
MEDLAEOO_01212 5.8e-215 tig D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
MEDLAEOO_01213 2e-233 clpX O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MEDLAEOO_01214 1.4e-104 engB D Necessary for normal cell division and for the maintenance of normal septation
MEDLAEOO_01215 7.8e-39 yjeM E Amino Acid
MEDLAEOO_01216 3.4e-175 yjeM E Amino Acid
MEDLAEOO_01217 2.3e-192 dapF 5.1.1.7 E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MEDLAEOO_01218 1.9e-258 lysC 2.7.2.4 E Belongs to the aspartokinase family
MEDLAEOO_01219 1.3e-246 lysA 4.1.1.19, 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
MEDLAEOO_01220 2.8e-75 dapD 2.3.1.117, 2.3.1.89 E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
MEDLAEOO_01221 2e-219 hipO 3.5.1.47 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
MEDLAEOO_01222 9.8e-177 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MEDLAEOO_01223 7e-144 dapB 1.17.1.8 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
MEDLAEOO_01224 2.7e-216 aspC 2.6.1.1 E Aminotransferase
MEDLAEOO_01225 2.6e-197 asd 1.2.1.11 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MEDLAEOO_01226 2.1e-194 pbpX1 V Beta-lactamase
MEDLAEOO_01227 1.2e-299 I Protein of unknown function (DUF2974)
MEDLAEOO_01228 0.0 rnjA J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MEDLAEOO_01229 3.5e-32 ykzG S Belongs to the UPF0356 family
MEDLAEOO_01230 8.9e-101 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
MEDLAEOO_01231 0.0 typA T GTP-binding protein TypA
MEDLAEOO_01232 5.9e-211 ftsW D Belongs to the SEDS family
MEDLAEOO_01233 5.1e-54 ylbG S Uncharacterized protein conserved in bacteria (DUF2129)
MEDLAEOO_01234 4.5e-97 rsmD 2.1.1.171 L RNA methyltransferase, RsmD family
MEDLAEOO_01235 3.6e-82 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MEDLAEOO_01236 2.4e-187 ylbL T Belongs to the peptidase S16 family
MEDLAEOO_01237 3.1e-79 comEA L Competence protein ComEA
MEDLAEOO_01238 0.0 comEC S Competence protein ComEC
MEDLAEOO_01239 2.6e-175 holA 2.7.7.7 L DNA polymerase III delta subunit
MEDLAEOO_01240 2.6e-34 rpsT J Binds directly to 16S ribosomal RNA
MEDLAEOO_01241 1.6e-42 rpsO J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MEDLAEOO_01242 3e-310 rnjB J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MEDLAEOO_01243 1.3e-148
MEDLAEOO_01244 1.5e-225 tuf J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MEDLAEOO_01245 6.6e-34 L An automated process has identified a potential problem with this gene model
MEDLAEOO_01246 6.3e-132 S SLAP domain
MEDLAEOO_01248 5.4e-215 NU Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
MEDLAEOO_01249 7.7e-181 atl 3.2.1.96, 3.5.1.28 GH73 M N-acetylmuramoyl-L-alanine amidase
MEDLAEOO_01250 0.0 yjbQ P TrkA C-terminal domain protein
MEDLAEOO_01251 1.7e-106 pcp 3.4.19.3 O Removes 5-oxoproline from various penultimate amino acid residues except L-proline
MEDLAEOO_01252 2.1e-161 S Oxidoreductase family, NAD-binding Rossmann fold
MEDLAEOO_01253 2.1e-130
MEDLAEOO_01254 2.1e-116
MEDLAEOO_01255 5e-133 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MEDLAEOO_01256 1.4e-98 G Aldose 1-epimerase
MEDLAEOO_01257 2.7e-202 brpA K Cell envelope-like function transcriptional attenuator common domain protein
MEDLAEOO_01258 1.6e-111 plsY 2.3.1.15 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
MEDLAEOO_01259 0.0 XK27_08315 M Sulfatase
MEDLAEOO_01260 4e-57 K Helix-turn-helix domain
MEDLAEOO_01261 2.7e-111 ppiB 5.2.1.8 G PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MEDLAEOO_01262 2.1e-171 ppaC 3.6.1.1 C inorganic pyrophosphatase
MEDLAEOO_01263 5.6e-183 K Transcriptional regulator
MEDLAEOO_01264 0.0 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
MEDLAEOO_01265 0.0 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
MEDLAEOO_01266 3.5e-109 plsY 2.3.1.15, 3.5.1.104 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
MEDLAEOO_01267 0.0 snf 2.7.11.1 KL domain protein
MEDLAEOO_01268 2e-35
MEDLAEOO_01270 3.8e-104 pncA Q Isochorismatase family
MEDLAEOO_01271 4.9e-118
MEDLAEOO_01274 3.6e-63
MEDLAEOO_01275 1.4e-34
MEDLAEOO_01276 1.6e-92 ydiM G Major facilitator superfamily
MEDLAEOO_01277 7.1e-200 pheS 6.1.1.20 J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MEDLAEOO_01278 0.0 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
MEDLAEOO_01279 2.4e-62 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
MEDLAEOO_01280 4.3e-169 ldh 1.1.1.27 C lactate/malate dehydrogenase, alpha/beta C-terminal domain
MEDLAEOO_01281 1.9e-158 metQ1 P Belongs to the nlpA lipoprotein family
MEDLAEOO_01282 1.9e-25
MEDLAEOO_01283 0.0 mco Q Multicopper oxidase
MEDLAEOO_01284 1.2e-151 S Sucrose-6F-phosphate phosphohydrolase
MEDLAEOO_01285 0.0 oppA E ABC transporter
MEDLAEOO_01286 5.8e-230 Q Imidazolonepropionase and related amidohydrolases
MEDLAEOO_01287 4e-245 3.5.1.47 S Peptidase dimerisation domain
MEDLAEOO_01288 3e-137 S Protein of unknown function (DUF3100)
MEDLAEOO_01289 5.7e-46 S An automated process has identified a potential problem with this gene model
MEDLAEOO_01290 2.2e-22
MEDLAEOO_01291 3.3e-140 repB EP Plasmid replication protein
MEDLAEOO_01292 1e-78 S helix_turn_helix, Deoxyribose operon repressor
MEDLAEOO_01293 2.4e-174 ulaG S Beta-lactamase superfamily domain
MEDLAEOO_01294 1.5e-61 cmtB 2.7.1.194, 2.7.1.197, 2.7.1.200, 2.7.1.202 G Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
MEDLAEOO_01295 5.3e-233 ulaA S PTS system sugar-specific permease component
MEDLAEOO_01296 4.5e-30 sgaB 2.7.1.194 G PTS system, Lactose/Cellobiose specific IIB subunit
MEDLAEOO_01297 2.8e-90 ulaD 4.1.1.85, 4.1.2.43 G Orotidine 5'-phosphate decarboxylase / HUMPS family
MEDLAEOO_01298 7.2e-129 ulaE 5.1.3.22 G Xylose isomerase-like TIM barrel
MEDLAEOO_01299 4.9e-123 araD 4.1.2.17, 5.1.3.4 G links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source
MEDLAEOO_01300 5.2e-68 L haloacid dehalogenase-like hydrolase
MEDLAEOO_01301 0.0 xfp 4.1.2.22, 4.1.2.9 G Phosphoketolase
MEDLAEOO_01302 1.4e-16 L Transposase
MEDLAEOO_01303 1.9e-12 L Transposase
MEDLAEOO_01304 2.6e-56 K Acetyltransferase (GNAT) domain
MEDLAEOO_01305 1.2e-10
MEDLAEOO_01306 2.8e-65 K LytTr DNA-binding domain
MEDLAEOO_01307 1.2e-49 S Protein of unknown function (DUF3021)
MEDLAEOO_01308 2.4e-104 thiJ 2.7.11.1, 3.5.1.124 S DJ-1/PfpI family
MEDLAEOO_01309 5.1e-119 3.1.3.18, 3.8.1.2 S Haloacid dehalogenase-like hydrolase
MEDLAEOO_01310 6.4e-134 S membrane transporter protein
MEDLAEOO_01311 3.4e-126 gpmB G Belongs to the phosphoglycerate mutase family
MEDLAEOO_01312 5.1e-162 czcD P cation diffusion facilitator family transporter
MEDLAEOO_01313 1.4e-23
MEDLAEOO_01314 2.6e-126 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MEDLAEOO_01315 5.4e-183 S AAA domain
MEDLAEOO_01316 3.3e-44
MEDLAEOO_01317 4.3e-266 pepC 3.4.22.40 E Peptidase C1-like family
MEDLAEOO_01318 2.7e-51
MEDLAEOO_01319 1.8e-101 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F dUTP diphosphatase
MEDLAEOO_01320 2.7e-255 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MEDLAEOO_01321 1.6e-290 gltX 6.1.1.17, 6.1.1.24 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MEDLAEOO_01322 7.5e-277 cysS 6.1.1.16, 6.3.1.13 J Belongs to the class-I aminoacyl-tRNA synthetase family
MEDLAEOO_01323 5.1e-75 mrnC J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MEDLAEOO_01324 1.7e-139 rlmB 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MEDLAEOO_01325 1.2e-94 sigH K Belongs to the sigma-70 factor family
MEDLAEOO_01326 1.7e-34
MEDLAEOO_01327 8.4e-287 gntK 2.7.1.12, 2.7.1.17 G Belongs to the FGGY kinase family
MEDLAEOO_01328 0.0 dxs 2.2.1.7 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MEDLAEOO_01329 3.6e-24 secE U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
MEDLAEOO_01330 1.2e-100 nusG K Participates in transcription elongation, termination and antitermination
MEDLAEOO_01331 1.2e-68 rplK J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MEDLAEOO_01332 3.2e-124 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
MEDLAEOO_01333 2.8e-157 pstS P Phosphate
MEDLAEOO_01334 1.9e-162 pstC P probably responsible for the translocation of the substrate across the membrane
MEDLAEOO_01335 6.5e-154 pstA P Phosphate transport system permease protein PstA
MEDLAEOO_01336 5e-145 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
MEDLAEOO_01337 3.9e-139 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
MEDLAEOO_01338 2.2e-117 phoU P Plays a role in the regulation of phosphate uptake
MEDLAEOO_01339 4.8e-90 L An automated process has identified a potential problem with this gene model
MEDLAEOO_01340 1.5e-11 GT2,GT4 M family 8
MEDLAEOO_01341 7e-84 rplJ J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MEDLAEOO_01342 1.8e-54 rplL J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
MEDLAEOO_01343 1.9e-139 potC 2.1.1.172, 2.1.1.80, 3.1.1.61 J Ion channel
MEDLAEOO_01344 1.3e-116 rsmC 2.1.1.172 J Methyltransferase
MEDLAEOO_01345 9e-26
MEDLAEOO_01346 2.2e-90 tadA 3.5.4.33 F Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
MEDLAEOO_01347 0.0 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MEDLAEOO_01348 5.1e-84 2.4.1.58 GT8 M family 8
MEDLAEOO_01349 8.2e-41 yaaK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MEDLAEOO_01350 1.6e-108 recR L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MEDLAEOO_01351 1.1e-34 S Protein of unknown function (DUF2508)
MEDLAEOO_01352 1.6e-114 tmk 2.7.4.9 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MEDLAEOO_01353 8.9e-53 yaaQ S Cyclic-di-AMP receptor
MEDLAEOO_01354 1.5e-155 holB 2.7.7.7 L DNA polymerase III
MEDLAEOO_01355 1.8e-59 yabA L Involved in initiation control of chromosome replication
MEDLAEOO_01356 5.1e-156 rsmI 2.1.1.198 H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MEDLAEOO_01357 1.4e-130 fat 3.1.2.21 I Acyl-ACP thioesterase
MEDLAEOO_01358 2.2e-85 S ECF transporter, substrate-specific component
MEDLAEOO_01359 2.4e-133 yeaZ 2.3.1.234 O Universal bacterial protein YeaZ
MEDLAEOO_01360 7.4e-97 rimI 2.3.1.128 K Ribosomal-protein-alanine acetyltransferase
MEDLAEOO_01361 3.8e-193 tsaD 2.3.1.234 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MEDLAEOO_01362 2.1e-106 L Transposase IS66 family
MEDLAEOO_01363 2.4e-127 L Transposase and inactivated derivatives
MEDLAEOO_01364 8.7e-34 S Transposase C of IS166 homeodomain
MEDLAEOO_01365 9.3e-64 L PFAM IS66 Orf2 family protein
MEDLAEOO_01366 7.7e-22
MEDLAEOO_01367 7e-43 yfdE 2.8.3.16, 2.8.3.19 C Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate
MEDLAEOO_01368 6.6e-182 frc 2.8.3.16, 2.8.3.19 C Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate
MEDLAEOO_01369 3.4e-284 oxc 4.1.1.8 EH Belongs to the TPP enzyme family
MEDLAEOO_01370 0.0 uup S ABC transporter, ATP-binding protein
MEDLAEOO_01371 5.8e-112 rex K Modulates transcription in response to changes in cellular NADH NAD( ) redox state
MEDLAEOO_01372 1.2e-16
MEDLAEOO_01373 2.1e-255 S Archaea bacterial proteins of unknown function
MEDLAEOO_01374 0.0 malZ 3.2.1.20 GH31 G Belongs to the glycosyl hydrolase 31 family
MEDLAEOO_01375 3e-270 glcD2 1.1.3.15 C FAD linked oxidases, C-terminal domain
MEDLAEOO_01376 1e-24
MEDLAEOO_01377 9.5e-26
MEDLAEOO_01378 2.5e-33
MEDLAEOO_01379 1.4e-53 S Enterocin A Immunity
MEDLAEOO_01380 8e-145 racD 5.1.1.13 M Belongs to the aspartate glutamate racemases family
MEDLAEOO_01381 5.5e-305 murE 6.3.2.13, 6.3.2.7 M Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MEDLAEOO_01382 6.6e-207 hpk31 2.7.13.3 T His Kinase A (phospho-acceptor) domain
MEDLAEOO_01383 9.6e-121 K response regulator
MEDLAEOO_01385 0.0 V ABC transporter
MEDLAEOO_01386 4.2e-144 V ABC transporter, ATP-binding protein
MEDLAEOO_01387 1.2e-145 V ABC transporter, ATP-binding protein
MEDLAEOO_01389 2e-10 isp2 L PFAM transposase, IS204 IS1001 IS1096 IS1165 family protein
MEDLAEOO_01390 9.5e-82 XK27_04435 3.5.4.5 J FR47-like protein
MEDLAEOO_01391 1.4e-36 S Cytochrome B5
MEDLAEOO_01392 6e-168 arbZ I Phosphate acyltransferases
MEDLAEOO_01393 1.6e-182 arbY M Glycosyl transferase family 8
MEDLAEOO_01394 5e-184 arbY M Glycosyl transferase family 8
MEDLAEOO_01395 5e-156 arbx M Glycosyl transferase family 8
MEDLAEOO_01396 1.6e-148 arbV 2.3.1.51 I Acyl-transferase
MEDLAEOO_01398 4.9e-34
MEDLAEOO_01400 4.8e-131 K response regulator
MEDLAEOO_01401 5e-305 vicK 2.7.13.3 T Histidine kinase
MEDLAEOO_01402 1.6e-257 yycH S YycH protein
MEDLAEOO_01403 3.4e-149 yycI S YycH protein
MEDLAEOO_01404 4.1e-147 vicX 3.1.26.11 S domain protein
MEDLAEOO_01405 1.6e-161 htrA 3.4.21.107 O serine protease
MEDLAEOO_01406 1e-81 rlmH 2.1.1.177 J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MEDLAEOO_01407 9.4e-261 L COG2963 Transposase and inactivated derivatives
MEDLAEOO_01408 1.5e-239 G Bacterial extracellular solute-binding protein
MEDLAEOO_01409 1e-60 pdxH S Pyridoxamine 5'-phosphate oxidase
MEDLAEOO_01410 7.7e-238 XK27_01810 S Calcineurin-like phosphoesterase
MEDLAEOO_01412 0.0 S SLAP domain
MEDLAEOO_01413 0.0 hsdR 3.1.21.3 L DEAD/DEAH box helicase
MEDLAEOO_01414 3.6e-216 S AAA domain, putative AbiEii toxin, Type IV TA system
MEDLAEOO_01415 1.4e-283 hsdM 2.1.1.72 V type I restriction-modification system
MEDLAEOO_01416 1.8e-129 hsdS 3.1.21.3 V Type I restriction modification DNA specificity domain
MEDLAEOO_01417 1.3e-74 pssE S Glycosyltransferase family 28 C-terminal domain
MEDLAEOO_01418 2e-104 GT4 M Glycosyl transferases group 1
MEDLAEOO_01419 2.4e-52 Z012_10770 M Domain of unknown function (DUF1919)
MEDLAEOO_01420 1.5e-88 fcbD 2.7.8.12 GT2 M Glycosyltransferase like family 2
MEDLAEOO_01421 2.9e-72 S Bacterial transferase hexapeptide (six repeats)
MEDLAEOO_01423 4.3e-74 epsJ_2 M Glycosyltransferase like family 2
MEDLAEOO_01424 6.5e-151 S Membrane protein involved in the export of O-antigen and teichoic acid
MEDLAEOO_01425 9.9e-67 rpe 5.1.3.1 G Belongs to the ribulose-phosphate 3-epimerase family
MEDLAEOO_01426 1.5e-40 2.7.1.200, 2.7.1.202 GT Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
MEDLAEOO_01427 7.9e-201 G PTS system sugar-specific permease component
MEDLAEOO_01428 7.6e-35 2.7.1.200 G PTS system, Lactose/Cellobiose specific IIB subunit
MEDLAEOO_01429 1.4e-76 S Uncharacterised protein family UPF0047
MEDLAEOO_01430 9.4e-64 kdsD 5.3.1.13 M SIS domain
MEDLAEOO_01431 2.9e-48 5.3.1.27 M SIS domain
MEDLAEOO_01432 4.9e-172 2.7.1.202 GKT Mga helix-turn-helix domain
MEDLAEOO_01433 0.0 fusA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MEDLAEOO_01434 2.7e-82 rpsG J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
MEDLAEOO_01435 7.8e-70 rpsL J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MEDLAEOO_01436 3.6e-120 pilD 3.4.23.43 NOU Bacterial Peptidase A24 N-terminal domain
MEDLAEOO_01437 0.0 rpoC 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MEDLAEOO_01438 0.0 rpoB 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MEDLAEOO_01439 0.0 clpC O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
MEDLAEOO_01440 1.3e-277 arlS 2.7.13.3 T Histidine kinase
MEDLAEOO_01441 1.2e-126 K response regulator
MEDLAEOO_01442 4.7e-97 yceD S Uncharacterized ACR, COG1399
MEDLAEOO_01443 1.7e-215 ylbM S Belongs to the UPF0348 family
MEDLAEOO_01444 5.3e-59 rsfS J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
MEDLAEOO_01445 4.3e-109 nadD 2.7.6.3, 2.7.7.18 H Hydrolase, HD family
MEDLAEOO_01446 1.3e-122 nadD 2.7.7.18, 3.6.1.55 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MEDLAEOO_01447 4.4e-200 yqeH S Ribosome biogenesis GTPase YqeH
MEDLAEOO_01448 4.2e-84 yqeG S HAD phosphatase, family IIIA
MEDLAEOO_01449 6e-200 tnpB L Putative transposase DNA-binding domain
MEDLAEOO_01450 6.9e-152 add 3.5.4.4 F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MEDLAEOO_01451 3e-57 rplT J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MEDLAEOO_01452 8.1e-28 rpmI J Belongs to the bacterial ribosomal protein bL35 family
MEDLAEOO_01453 3.2e-72 infC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MEDLAEOO_01454 4e-98 rihB 3.2.2.1 F Nucleoside
MEDLAEOO_01455 3.7e-101 potB E Binding-protein-dependent transport system inner membrane component
MEDLAEOO_01456 0.0 dnaE 2.7.7.7 L DNA polymerase
MEDLAEOO_01457 2.3e-23 S Protein of unknown function (DUF2929)
MEDLAEOO_01458 2.6e-310 cpdB 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
MEDLAEOO_01459 1.3e-27 rpmF J Belongs to the bacterial ribosomal protein bL32 family
MEDLAEOO_01460 1.5e-34 yrvD S Lipopolysaccharide assembly protein A domain
MEDLAEOO_01461 5.1e-142 XK27_05435 1.1.1.100 S Belongs to the short-chain dehydrogenases reductases (SDR) family
MEDLAEOO_01462 5.4e-175 rnz 3.1.26.11 J Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
MEDLAEOO_01463 2.2e-292 I Acyltransferase
MEDLAEOO_01464 1.7e-243 obg S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MEDLAEOO_01465 0.0 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
MEDLAEOO_01466 6.8e-110 dedA 3.1.3.1 S SNARE associated Golgi protein
MEDLAEOO_01467 8.8e-29
MEDLAEOO_01470 4.9e-111 K Helix-turn-helix XRE-family like proteins
MEDLAEOO_01471 2.5e-75 K Helix-turn-helix domain
MEDLAEOO_01472 1.5e-25 S CAAX protease self-immunity
MEDLAEOO_01473 1.4e-22 S CAAX protease self-immunity
MEDLAEOO_01474 7.6e-26 WQ51_00220 K Helix-turn-helix XRE-family like proteins
MEDLAEOO_01476 1.6e-96 ybaT E Amino acid permease
MEDLAEOO_01477 1.7e-07 S LPXTG cell wall anchor motif
MEDLAEOO_01478 4.4e-146 S Putative ABC-transporter type IV
MEDLAEOO_01480 9.6e-28 ftsZ M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
MEDLAEOO_01481 3.4e-226 L COG2963 Transposase and inactivated derivatives
MEDLAEOO_01482 9.5e-237 L COG2963 Transposase and inactivated derivatives
MEDLAEOO_01483 4.7e-46 pspC KT PspC domain
MEDLAEOO_01485 1.3e-240 dacA 3.4.16.4 M Belongs to the peptidase S11 family
MEDLAEOO_01486 2.8e-154 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MEDLAEOO_01487 6.7e-98 M ErfK YbiS YcfS YnhG
MEDLAEOO_01488 0.0 argS 6.1.1.19 J Arginyl-tRNA synthetase
MEDLAEOO_01489 4.6e-171 fba 4.1.2.13, 4.1.2.29 G Fructose-1,6-bisphosphate aldolase, class II
MEDLAEOO_01490 2.2e-85 S PFAM Archaeal ATPase
MEDLAEOO_01491 3.9e-36 S PFAM Archaeal ATPase
MEDLAEOO_01492 7.1e-34 S PFAM Archaeal ATPase
MEDLAEOO_01493 7.7e-26
MEDLAEOO_01494 1.2e-70 menA 2.5.1.74 H UbiA prenyltransferase family
MEDLAEOO_01495 6.9e-47 mdtG EGP Major facilitator Superfamily
MEDLAEOO_01496 5e-152 mdtG EGP Major facilitator Superfamily
MEDLAEOO_01497 1.3e-174
MEDLAEOO_01498 2.8e-47 lysM M LysM domain
MEDLAEOO_01499 0.0 pepN 3.4.11.2 E aminopeptidase
MEDLAEOO_01500 1.3e-250 dtpT U amino acid peptide transporter
MEDLAEOO_01501 1.2e-18 S Sugar efflux transporter for intercellular exchange
MEDLAEOO_01502 6.6e-70 XK27_02470 K LytTr DNA-binding domain
MEDLAEOO_01503 2.1e-92 liaI S membrane
MEDLAEOO_01504 4e-16
MEDLAEOO_01505 3.9e-186 S Putative peptidoglycan binding domain
MEDLAEOO_01506 1.9e-157 2.7.7.12 C Domain of unknown function (DUF4931)
MEDLAEOO_01507 9e-121
MEDLAEOO_01508 5.5e-148 S cog cog1373
MEDLAEOO_01509 0.0 4.2.1.53 S Myosin-crossreactive antigen
MEDLAEOO_01510 2e-91 yxdD K Bacterial regulatory proteins, tetR family
MEDLAEOO_01511 1.9e-259 emrY EGP Major facilitator Superfamily
MEDLAEOO_01516 1.1e-94 MA20_25245 K Acetyltransferase (GNAT) domain
MEDLAEOO_01517 4.9e-254 rumA 2.1.1.190 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MEDLAEOO_01518 6.3e-201 pbpX V Beta-lactamase
MEDLAEOO_01519 2.8e-244 nhaC C Na H antiporter NhaC
MEDLAEOO_01520 1.4e-147 I transferase activity, transferring acyl groups other than amino-acyl groups
MEDLAEOO_01521 2.6e-57
MEDLAEOO_01522 4.3e-108 ybhL S Belongs to the BI1 family
MEDLAEOO_01523 2.7e-171 yegS 2.7.1.107 G Lipid kinase
MEDLAEOO_01524 2.7e-274 gatB 6.1.1.12, 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MEDLAEOO_01525 2.9e-268 gatA 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
MEDLAEOO_01526 1.5e-49 gatC 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MEDLAEOO_01527 5.8e-203 camS S sex pheromone
MEDLAEOO_01528 0.0 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MEDLAEOO_01529 0.0 pcrA 3.6.4.12 L ATP-dependent DNA helicase
MEDLAEOO_01530 5.2e-84 acmC 3.2.1.17, 3.2.1.96 NU mannosyl-glycoprotein
MEDLAEOO_01532 4.1e-83 ydcK S Belongs to the SprT family
MEDLAEOO_01533 7.7e-134 M Glycosyltransferase sugar-binding region containing DXD motif
MEDLAEOO_01534 6e-258 epsU S Polysaccharide biosynthesis protein
MEDLAEOO_01535 7e-225 M CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
MEDLAEOO_01536 0.0 pacL 3.6.3.8 P P-type ATPase
MEDLAEOO_01537 1.4e-204 tnpB L Putative transposase DNA-binding domain
MEDLAEOO_01538 1.2e-152 nadE 6.3.1.5 F Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
MEDLAEOO_01539 2.4e-286 pncB 6.3.4.21 F Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MEDLAEOO_01540 1.7e-204 csaB M Glycosyl transferases group 1
MEDLAEOO_01541 2.1e-134 tagA 2.4.1.187 GT26 F Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid
MEDLAEOO_01542 5.1e-71 tagD 2.7.7.15, 2.7.7.39 IM Glycerol-3-phosphate cytidylyltransferase
MEDLAEOO_01543 4.6e-123 gntR1 K UTRA
MEDLAEOO_01544 3.3e-179
MEDLAEOO_01545 3.4e-45 oppA2 E ABC transporter, substratebinding protein
MEDLAEOO_01546 1.2e-238 oppA2 E ABC transporter, substratebinding protein
MEDLAEOO_01549 1.1e-240 npr 1.11.1.1 C NADH oxidase
MEDLAEOO_01550 7.7e-12
MEDLAEOO_01551 3.7e-22 3.6.4.12 S transposase or invertase
MEDLAEOO_01552 6.7e-228 slpX S SLAP domain
MEDLAEOO_01553 4.4e-144 K SIS domain
MEDLAEOO_01554 8.1e-120 rpiA 5.3.1.6 G Ribose 5-phosphate isomerase A (phosphoriboisomerase A)
MEDLAEOO_01555 2.7e-185 XK27_10475 S Oxidoreductase family, NAD-binding Rossmann fold
MEDLAEOO_01556 6.5e-210 patA 2.6.1.1, 2.6.1.57 E Aminotransferase
MEDLAEOO_01558 0.0 mgtA 3.6.3.2 P COG0474 Cation transport ATPase
MEDLAEOO_01560 1.2e-115 glpQ1 3.1.4.46 C glycerophosphoryl diester phosphodiesterase
MEDLAEOO_01561 6.6e-119 VY92_08690 5.3.1.32 G Antibiotic biosynthesis monooxygenase
MEDLAEOO_01562 2.6e-89 G Histidine phosphatase superfamily (branch 1)
MEDLAEOO_01563 1.2e-105 G Phosphoglycerate mutase family
MEDLAEOO_01564 4.7e-159 D nuclear chromosome segregation
MEDLAEOO_01565 5.8e-78 M LysM domain protein
MEDLAEOO_01566 2.8e-86 celB G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
MEDLAEOO_01567 4.1e-78 celB G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
MEDLAEOO_01568 1.5e-16 celB G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
MEDLAEOO_01569 6.2e-12
MEDLAEOO_01570 2.3e-172 pphA 3.1.3.16 T Calcineurin-like phosphoesterase
MEDLAEOO_01571 2.3e-30
MEDLAEOO_01573 2.9e-69 S Iron-sulphur cluster biosynthesis
MEDLAEOO_01601 7.9e-224 mgs 2.4.1.337 GT4 M Glycosyl transferase 4-like domain
MEDLAEOO_01602 1.4e-200 cpoA GT4 M Glycosyltransferase, group 1 family protein
MEDLAEOO_01603 1.4e-176 mprF S Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MEDLAEOO_01604 0.0 ltaS 2.7.8.20 M Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
MEDLAEOO_01605 1.7e-29 secG U Preprotein translocase
MEDLAEOO_01606 0.0 rnr J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
MEDLAEOO_01607 5.1e-78 smpB J the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
MEDLAEOO_01608 1.8e-73 C nitroreductase
MEDLAEOO_01609 1.9e-70 S Domain of unknown function (DUF4767)
MEDLAEOO_01610 5.8e-244 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
MEDLAEOO_01611 2.5e-147 yitS S Uncharacterised protein, DegV family COG1307
MEDLAEOO_01612 4.2e-101 3.6.1.27 I Acid phosphatase homologues
MEDLAEOO_01613 5.6e-191 cbh 3.5.1.24 M Linear amide C-N hydrolase, choloylglycine hydrolase family protein
MEDLAEOO_01615 2e-178 MA20_14895 S Conserved hypothetical protein 698
MEDLAEOO_01616 1.1e-83 dps P Belongs to the Dps family
MEDLAEOO_01617 3.8e-20 1.3.5.4 C FAD dependent oxidoreductase
MEDLAEOO_01618 5.6e-101 yihX 3.1.3.10, 3.8.1.2 S Haloacid dehalogenase-like hydrolase
MEDLAEOO_01619 1.8e-58 S Putative adhesin
MEDLAEOO_01620 5.6e-65 L PFAM transposase IS116 IS110 IS902
MEDLAEOO_01621 0.0 clpE O Belongs to the ClpA ClpB family
MEDLAEOO_01622 2.3e-44 XK27_09445 S Domain of unknown function (DUF1827)
MEDLAEOO_01623 9.4e-305 prfC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MEDLAEOO_01624 1.4e-140 hlyX S Transporter associated domain
MEDLAEOO_01625 2.7e-74
MEDLAEOO_01626 1.6e-85
MEDLAEOO_01627 1.5e-144 recX 2.4.1.337 GT4 S Regulatory protein RecX
MEDLAEOO_01628 3e-262 rumA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MEDLAEOO_01629 1.4e-118 D Alpha beta
MEDLAEOO_01630 1.8e-38 D Alpha beta
MEDLAEOO_01631 9.4e-46
MEDLAEOO_01632 7e-23 cydA 1.10.3.14 C ubiquinol oxidase
MEDLAEOO_01633 3.7e-130 ybbH_2 K rpiR family
MEDLAEOO_01634 3.4e-195 S Bacterial protein of unknown function (DUF871)
MEDLAEOO_01635 4.1e-214 2.7.1.208, 2.7.1.211 G phosphotransferase system
MEDLAEOO_01636 1.8e-119 S Putative esterase
MEDLAEOO_01637 3.6e-120 murQ 4.2.1.126 G Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
MEDLAEOO_01638 1.3e-79 ybbH_2 K Helix-turn-helix domain, rpiR family
MEDLAEOO_01640 8.5e-260 qacA EGP Major facilitator Superfamily
MEDLAEOO_01641 1.7e-221 metK 2.5.1.6 H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MEDLAEOO_01644 6.2e-165 psaA P Belongs to the bacterial solute-binding protein 9 family
MEDLAEOO_01647 7.5e-183 yumC 1.18.1.2, 1.19.1.1, 1.8.1.9 C Ferredoxin--NADP reductase
MEDLAEOO_01648 4.5e-112 dedA S SNARE-like domain protein
MEDLAEOO_01649 3.7e-100 S Protein of unknown function (DUF1461)
MEDLAEOO_01650 3.4e-143 nagD 2.7.1.25, 3.1.3.41 G Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
MEDLAEOO_01651 2.1e-92 yutD S Protein of unknown function (DUF1027)
MEDLAEOO_01652 5.8e-274 yunD 3.1.3.5 F Belongs to the 5'-nucleotidase family
MEDLAEOO_01653 4.3e-55
MEDLAEOO_01654 2.3e-267 ugpQ 3.1.4.46 C glycerophosphoryl diester phosphodiesterase
MEDLAEOO_01655 3.2e-181 ccpA K catabolite control protein A
MEDLAEOO_01656 7e-214 pepQ 3.4.13.9 E Creatinase/Prolidase N-terminal domain
MEDLAEOO_01657 3.4e-23
MEDLAEOO_01659 2.5e-288 pipD E Dipeptidase
MEDLAEOO_01660 3.6e-161 ftsY U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
MEDLAEOO_01661 0.0 smc D Required for chromosome condensation and partitioning
MEDLAEOO_01662 1.9e-124 rnc 3.1.26.3 J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
MEDLAEOO_01663 2.1e-308 oppA E ABC transporter substrate-binding protein
MEDLAEOO_01664 3.1e-240 oppA E ABC transporter substrate-binding protein
MEDLAEOO_01665 3e-37
MEDLAEOO_01666 2.4e-110 K WHG domain
MEDLAEOO_01667 6.4e-96 nqr 1.5.1.36 S NADPH-dependent FMN reductase
MEDLAEOO_01668 2e-97 azr 1.5.1.36 S NADPH-dependent FMN reductase
MEDLAEOO_01669 6e-151 3.1.3.48 T Tyrosine phosphatase family
MEDLAEOO_01670 2.5e-180 apbE 2.7.1.180 H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
MEDLAEOO_01671 3e-53 cvpA S Colicin V production protein
MEDLAEOO_01672 1.2e-129 rsmG 2.1.1.170 J Specifically methylates the N7 position of a guanine in 16S rRNA
MEDLAEOO_01673 1.5e-147 noc K Belongs to the ParB family
MEDLAEOO_01674 3.4e-138 soj D Sporulation initiation inhibitor
MEDLAEOO_01675 5.5e-153 spo0J K Belongs to the ParB family
MEDLAEOO_01676 9.6e-45 yyzM S Bacterial protein of unknown function (DUF951)
MEDLAEOO_01677 3.6e-202 ychF J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
MEDLAEOO_01678 3.8e-137 XK27_01040 S Protein of unknown function (DUF1129)
MEDLAEOO_01679 3e-119 VY92_08690 5.3.1.32 G Antibiotic biosynthesis monooxygenase
MEDLAEOO_01680 9e-98
MEDLAEOO_01681 4.9e-108 K LysR substrate binding domain
MEDLAEOO_01682 1e-20
MEDLAEOO_01683 2.3e-215 S Sterol carrier protein domain
MEDLAEOO_01684 9.2e-95 citX 2.4.2.52, 2.7.7.61 HI Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
MEDLAEOO_01685 2e-105 argF 2.1.3.3, 2.7.2.2 E Belongs to the carbamate kinase family
MEDLAEOO_01686 4.3e-66 argF 2.1.3.3, 2.7.2.2 E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MEDLAEOO_01687 5.7e-233 arcA 3.5.3.6 E Arginine
MEDLAEOO_01688 9e-137 lysR5 K LysR substrate binding domain
MEDLAEOO_01689 0.0 mgtA 3.6.3.2, 3.6.3.6 P Cation transporter/ATPase, N-terminus
MEDLAEOO_01690 1e-48 S Metal binding domain of Ada
MEDLAEOO_01691 1.4e-52 EGP Sugar (and other) transporter
MEDLAEOO_01692 1e-104
MEDLAEOO_01693 8.2e-114 flpA 4.1.99.16, 4.2.3.22, 4.2.3.75 K helix_turn_helix, cAMP Regulatory protein
MEDLAEOO_01694 0.0 copA 3.6.3.54 P P-type ATPase
MEDLAEOO_01695 3.1e-49 silP 1.9.3.1, 3.6.3.54 S Cupredoxin-like domain
MEDLAEOO_01696 4.9e-58 silP 1.9.3.1, 3.6.3.54 S Cupredoxin-like domain
MEDLAEOO_01697 2.4e-36
MEDLAEOO_01700 3.7e-20
MEDLAEOO_01701 1.1e-139
MEDLAEOO_01702 3.7e-261 V ABC transporter transmembrane region
MEDLAEOO_01703 1.4e-37 S Putative adhesin
MEDLAEOO_01704 1.3e-116 S Peptidase family M23
MEDLAEOO_01705 1.8e-104 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MEDLAEOO_01707 4.6e-160 yitT S Uncharacterised 5xTM membrane BCR, YitT family COG1284
MEDLAEOO_01708 9.4e-118
MEDLAEOO_01709 2.8e-157 thrB 2.7.1.39 F Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
MEDLAEOO_01710 6.6e-221 hom 1.1.1.3, 2.7.2.4 E homoserine dehydrogenase
MEDLAEOO_01711 2.6e-280 thrC 4.2.3.1 E Threonine synthase
MEDLAEOO_01712 4.4e-258 lysC 2.7.2.4 E Belongs to the aspartokinase family
MEDLAEOO_01713 9.6e-103 pgm3 5.4.2.11 G Histidine phosphatase superfamily (branch 1)
MEDLAEOO_01714 8.4e-265 S Fibronectin type III domain
MEDLAEOO_01715 1.3e-240 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MEDLAEOO_01716 3.4e-53
MEDLAEOO_01718 4.6e-257 pepC 3.4.22.40 E aminopeptidase
MEDLAEOO_01719 1.3e-122 ypgQ S Metal dependent phosphohydrolases with conserved 'HD' motif.
MEDLAEOO_01720 1.7e-301 oppA E ABC transporter, substratebinding protein
MEDLAEOO_01721 1.6e-310 oppA E ABC transporter, substratebinding protein
MEDLAEOO_01722 1.7e-210 guaB 1.1.1.205 F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
MEDLAEOO_01723 1.1e-146 oppB P ABC-type dipeptide oligopeptide nickel transport systems, permease components
MEDLAEOO_01724 6.8e-187 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
MEDLAEOO_01725 2.7e-199 oppD P Belongs to the ABC transporter superfamily
MEDLAEOO_01726 1.9e-175 oppF P Belongs to the ABC transporter superfamily
MEDLAEOO_01727 1.8e-256 pepC 3.4.22.40 E aminopeptidase
MEDLAEOO_01728 1.5e-71 hsp O Belongs to the small heat shock protein (HSP20) family
MEDLAEOO_01729 2.6e-77 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
MEDLAEOO_01730 1.2e-112
MEDLAEOO_01732 1.7e-110 E Belongs to the SOS response-associated peptidase family
MEDLAEOO_01733 3.7e-193 trpS 6.1.1.2 J Belongs to the class-I aminoacyl-tRNA synthetase family
MEDLAEOO_01734 4e-89 comEB 3.5.4.12 F MafB19-like deaminase
MEDLAEOO_01735 2e-103 S TPM domain
MEDLAEOO_01736 0.0 mgtA 3.6.3.2 P COG0474 Cation transport ATPase
MEDLAEOO_01737 0.0 metG 6.1.1.10 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MEDLAEOO_01738 3e-147 tatD L hydrolase, TatD family
MEDLAEOO_01739 1e-99 rnmV 3.1.26.8 J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MEDLAEOO_01740 8.2e-157 ksgA 2.1.1.182 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
MEDLAEOO_01741 1e-38 veg S Biofilm formation stimulator VEG
MEDLAEOO_01742 9.4e-147 purR 2.4.2.22, 2.4.2.7 F pur operon repressor
MEDLAEOO_01743 1.3e-172 glmU 2.3.1.157, 2.7.7.23 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MEDLAEOO_01744 5.3e-80
MEDLAEOO_01745 1.9e-293 S SLAP domain
MEDLAEOO_01746 6e-177 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MEDLAEOO_01747 4.2e-172 2.7.1.2 GK ROK family
MEDLAEOO_01748 5.6e-43
MEDLAEOO_01749 3.6e-268 ywfO S Metal dependent phosphohydrolases with conserved 'HD' motif.
MEDLAEOO_01750 6.9e-69 S Domain of unknown function (DUF1934)
MEDLAEOO_01751 1.5e-46 rpoE K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
MEDLAEOO_01752 6.7e-311 pyrG 6.3.4.2 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
MEDLAEOO_01753 9.6e-247 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MEDLAEOO_01754 1.8e-74 K acetyltransferase
MEDLAEOO_01755 5.7e-285 pipD E Dipeptidase
MEDLAEOO_01756 3.7e-156 msmR K AraC-like ligand binding domain
MEDLAEOO_01757 1.5e-223 pbuX F xanthine permease
MEDLAEOO_01758 9e-104 xpt 2.4.2.22, 2.4.2.7 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
MEDLAEOO_01759 2.4e-43 K Helix-turn-helix
MEDLAEOO_01760 7.8e-304 guaA 2.3.1.128, 6.3.5.2 F Catalyzes the synthesis of GMP from XMP
MEDLAEOO_01761 7.8e-168 sthIM 2.1.1.72 L DNA methylase
MEDLAEOO_01762 7.5e-246 res_1 3.1.21.5 L Type III restriction enzyme, res subunit
MEDLAEOO_01763 2.6e-40
MEDLAEOO_01764 1.1e-11
MEDLAEOO_01765 2.1e-93 D ftsk spoiiie
MEDLAEOO_01766 1.9e-18
MEDLAEOO_01767 5.6e-57
MEDLAEOO_01768 9.5e-12 S Domain of unknown function (DUF3173)
MEDLAEOO_01769 8.6e-09 L Belongs to the 'phage' integrase family
MEDLAEOO_01770 5.9e-37 M domain protein
MEDLAEOO_01772 6.5e-249 yjjP S Putative threonine/serine exporter
MEDLAEOO_01773 2.6e-177 citR K Putative sugar-binding domain
MEDLAEOO_01774 1.5e-50
MEDLAEOO_01775 5.5e-09
MEDLAEOO_01776 2.9e-66 S Domain of unknown function DUF1828
MEDLAEOO_01777 1.5e-95 S UPF0397 protein
MEDLAEOO_01778 0.0 ykoD P ABC transporter, ATP-binding protein
MEDLAEOO_01779 3.6e-146 cbiQ P cobalt transport
MEDLAEOO_01780 7e-22
MEDLAEOO_01781 9.3e-72 yeaL S Protein of unknown function (DUF441)
MEDLAEOO_01782 1.1e-66 L Transposase and inactivated derivatives, IS30 family
MEDLAEOO_01783 0.0 mngB 3.2.1.170, 3.2.1.24 GH38 G Glycosyl hydrolases family 38 N-terminal domain
MEDLAEOO_01784 1.4e-137 licR 2.7.1.200, 2.7.1.202 G Mga helix-turn-helix domain
MEDLAEOO_01785 5.5e-281 ybgG 3.2.1.170 GH38 G Glycosyl hydrolases family 38 N-terminal domain
MEDLAEOO_01786 1.4e-150 mngA 2.7.1.195, 2.7.1.202 U system, fructose-specific IIC component
MEDLAEOO_01787 5.3e-37 mngA 2.7.1.195, 2.7.1.202 G Psort location Cytoplasmic, score 9.98
MEDLAEOO_01788 2e-42 fryA 2.7.1.200, 2.7.1.202 G Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
MEDLAEOO_01789 1.9e-116 yhiD S MgtC family
MEDLAEOO_01791 1.4e-18 K Helix-turn-helix XRE-family like proteins
MEDLAEOO_01792 6.9e-64
MEDLAEOO_01793 2.6e-84
MEDLAEOO_01794 1.4e-134 D Ftsk spoiiie family protein
MEDLAEOO_01795 2.2e-140 S Replication initiation factor
MEDLAEOO_01796 3.9e-55
MEDLAEOO_01797 2.3e-26
MEDLAEOO_01798 9.5e-220 L Belongs to the 'phage' integrase family
MEDLAEOO_01800 2.5e-62 yfiL V ABC transporter
MEDLAEOO_01801 2.9e-46 V Transport permease protein
MEDLAEOO_01802 3.4e-09
MEDLAEOO_01803 1.1e-68 sagB C Nitroreductase family
MEDLAEOO_01804 1.2e-222 patA 2.6.1.1 E Aminotransferase
MEDLAEOO_01805 0.0 aspS 6.1.1.12 J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
MEDLAEOO_01806 5.8e-244 hisS 6.1.1.21 J histidyl-tRNA synthetase
MEDLAEOO_01807 6e-76 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
MEDLAEOO_01808 0.0 relA 2.7.6.5 KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MEDLAEOO_01809 8.5e-60
MEDLAEOO_01810 6.5e-176 prmA J Ribosomal protein L11 methyltransferase
MEDLAEOO_01811 8.2e-85 ybaK S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MEDLAEOO_01812 8.8e-58 S Peptidase propeptide and YPEB domain
MEDLAEOO_01813 1.3e-102 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MEDLAEOO_01814 2.5e-169 coaA 2.7.1.33 F Pantothenic acid kinase
MEDLAEOO_01815 7.1e-98 E GDSL-like Lipase/Acylhydrolase
MEDLAEOO_01816 7.5e-74 yjcF S Acetyltransferase (GNAT) domain
MEDLAEOO_01817 1.6e-143 aatB ET ABC transporter substrate-binding protein
MEDLAEOO_01818 1e-105 glnQ 3.6.3.21 E ABC transporter
MEDLAEOO_01819 1.5e-107 glnP P ABC transporter permease
MEDLAEOO_01820 0.0 helD 3.6.4.12 L DNA helicase
MEDLAEOO_01821 2.7e-124 XK27_08875 O PFAM peptidase M10A and M12B, matrixin and adamalysin
MEDLAEOO_01822 1.4e-126 pgm3 G Phosphoglycerate mutase family
MEDLAEOO_01823 5.9e-241 S response to antibiotic
MEDLAEOO_01824 4.9e-125
MEDLAEOO_01825 0.0 3.6.3.8 P P-type ATPase
MEDLAEOO_01826 8.7e-66 2.7.1.191 G PTS system fructose IIA component
MEDLAEOO_01827 4.4e-43
MEDLAEOO_01828 5.9e-09
MEDLAEOO_01829 9.4e-186 ansA 3.5.1.1 EJ L-asparaginase, type I
MEDLAEOO_01830 5.3e-136 glvR K Helix-turn-helix domain, rpiR family
MEDLAEOO_01831 2.7e-268 aglB 3.2.1.122, 3.2.1.86 GH4,GT4 G Family 4 glycosyl hydrolase C-terminal domain
MEDLAEOO_01832 3.9e-287 clcA P chloride
MEDLAEOO_01833 4e-32 E Zn peptidase
MEDLAEOO_01834 3.7e-58 ps115 K Helix-turn-helix XRE-family like proteins
MEDLAEOO_01835 1.2e-44
MEDLAEOO_01836 9.1e-106 S Bacteriocin helveticin-J
MEDLAEOO_01837 1.3e-117 S SLAP domain
MEDLAEOO_01838 3.5e-136 S SLAP domain
MEDLAEOO_01839 8e-210
MEDLAEOO_01840 1.2e-18
MEDLAEOO_01841 7.3e-175 EGP Sugar (and other) transporter
MEDLAEOO_01842 9e-161 V ABC transporter transmembrane region
MEDLAEOO_01843 7e-68 V ABC transporter transmembrane region
MEDLAEOO_01844 3.8e-65 yybA 2.3.1.57 K Transcriptional regulator
MEDLAEOO_01845 4.7e-83 paiA 2.3.1.57 K Acetyltransferase (GNAT) domain
MEDLAEOO_01846 2.5e-72 S Peptidase propeptide and YPEB domain
MEDLAEOO_01847 3.4e-76 S Peptidase propeptide and YPEB domain
MEDLAEOO_01848 5.2e-187 T GHKL domain
MEDLAEOO_01849 3.1e-130 T Transcriptional regulatory protein, C terminal
MEDLAEOO_01850 2.1e-179 pip 3.4.11.5 E Releases the N-terminal proline from various substrates
MEDLAEOO_01851 2.9e-277 V ABC transporter transmembrane region
MEDLAEOO_01852 2.1e-135 UW LPXTG-motif cell wall anchor domain protein
MEDLAEOO_01853 1.3e-161 UW LPXTG-motif cell wall anchor domain protein
MEDLAEOO_01854 3.3e-45 UW LPXTG-motif cell wall anchor domain protein
MEDLAEOO_01855 9.1e-10 UW LPXTG-motif cell wall anchor domain protein
MEDLAEOO_01856 1.3e-248 serS 6.1.1.11 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MEDLAEOO_01857 7.5e-100 J Acetyltransferase (GNAT) domain
MEDLAEOO_01858 1.4e-110 yjbF S SNARE associated Golgi protein
MEDLAEOO_01859 6e-151 I alpha/beta hydrolase fold
MEDLAEOO_01860 1.4e-156 hipB K Helix-turn-helix
MEDLAEOO_01861 1.4e-15 S cog cog1373
MEDLAEOO_01862 2.6e-138 S TerB-C domain
MEDLAEOO_01863 1.4e-245 P P-loop Domain of unknown function (DUF2791)
MEDLAEOO_01864 0.0 lhr L DEAD DEAH box helicase
MEDLAEOO_01865 1.4e-60
MEDLAEOO_01866 4.3e-228 amtB P ammonium transporter
MEDLAEOO_01867 4.4e-135 nfrA 1.5.1.38, 1.5.1.39 C nitroreductase
MEDLAEOO_01869 6.6e-61 psiE S Phosphate-starvation-inducible E
MEDLAEOO_01870 6.5e-113 yncA 2.3.1.79 S Maltose acetyltransferase
MEDLAEOO_01871 5.3e-26
MEDLAEOO_01872 8.5e-41 ptsH G phosphocarrier protein HPR
MEDLAEOO_01873 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MEDLAEOO_01874 3.9e-66 spxA 1.20.4.1 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
MEDLAEOO_01875 8.5e-139 mecA NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
MEDLAEOO_01876 1.4e-158 coiA 3.6.4.12 S Competence protein
MEDLAEOO_01877 4.6e-114 yjbH Q Thioredoxin
MEDLAEOO_01878 6.8e-110 yjbK S CYTH
MEDLAEOO_01879 1.2e-114 yjbM 2.7.6.5 S RelA SpoT domain protein
MEDLAEOO_01880 3.8e-153 nadK 2.7.1.23 F Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MEDLAEOO_01881 6.4e-173 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
MEDLAEOO_01882 0.0 mycA 4.2.1.53 S Myosin-crossreactive antigen
MEDLAEOO_01883 4.2e-92 S SNARE associated Golgi protein
MEDLAEOO_01884 1.8e-200 pgl 3.1.1.31 G Lactonase, 7-bladed beta-propeller
MEDLAEOO_01885 2.2e-66 srlB 2.7.1.198 G PTS system glucitol/sorbitol-specific IIA component
MEDLAEOO_01886 2.6e-214 yubA S AI-2E family transporter
MEDLAEOO_01887 4.2e-106 trmL 2.1.1.207 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
MEDLAEOO_01888 1.7e-69 WQ51_03320 S Protein of unknown function (DUF1149)
MEDLAEOO_01889 0.0 ftsK D Belongs to the FtsK SpoIIIE SftA family
MEDLAEOO_01890 9e-223 2.7.1.26, 2.7.7.2 S Peptidase M16 inactive domain protein
MEDLAEOO_01891 1.9e-236 S Peptidase M16
MEDLAEOO_01892 3.4e-132 IQ Enoyl-(Acyl carrier protein) reductase
MEDLAEOO_01893 5.2e-97 ymfM S Helix-turn-helix domain
MEDLAEOO_01894 1.1e-95 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MEDLAEOO_01895 4.2e-195 recA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MEDLAEOO_01896 7.4e-220 rny S Endoribonuclease that initiates mRNA decay
MEDLAEOO_01897 1.3e-210 tagO 2.7.8.33, 2.7.8.35 M transferase
MEDLAEOO_01898 5.1e-119 yvyE 3.4.13.9 S YigZ family
MEDLAEOO_01899 4.7e-246 comFA L Helicase C-terminal domain protein
MEDLAEOO_01900 9.4e-132 comFC S Competence protein
MEDLAEOO_01901 1.6e-94 hpf J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MEDLAEOO_01902 0.0 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
MEDLAEOO_01903 4.6e-188 prfB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MEDLAEOO_01904 5.1e-17
MEDLAEOO_01905 5.8e-180 hprK F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MEDLAEOO_01906 9.2e-158 lgt 2.1.1.199 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MEDLAEOO_01907 1.1e-186 gpsA 1.1.1.94 I Glycerol-3-phosphate dehydrogenase
MEDLAEOO_01908 3.9e-181 trxB 1.8.1.9 C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
MEDLAEOO_01909 0.0 pgm 5.4.2.2, 5.4.2.8 G Phosphoglucomutase phosphomannomutase, alpha beta alpha domain
MEDLAEOO_01910 0.0 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
MEDLAEOO_01911 0.0 uvrA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
MEDLAEOO_01912 4.1e-90 S Short repeat of unknown function (DUF308)
MEDLAEOO_01913 6.2e-165 rapZ S Displays ATPase and GTPase activities
MEDLAEOO_01914 1.8e-192 ybhK S Required for morphogenesis under gluconeogenic growth conditions
MEDLAEOO_01915 2.1e-171 whiA K May be required for sporulation
MEDLAEOO_01916 2.3e-99 clpP 3.4.21.92 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
MEDLAEOO_01917 0.0 S SH3-like domain
MEDLAEOO_01918 4.9e-111 ybbL S ABC transporter, ATP-binding protein
MEDLAEOO_01919 2.5e-130 ybbM S Uncharacterised protein family (UPF0014)
MEDLAEOO_01920 4.1e-133 cysA V ABC transporter, ATP-binding protein
MEDLAEOO_01921 0.0 V FtsX-like permease family
MEDLAEOO_01922 2.7e-258 yfnA E amino acid
MEDLAEOO_01923 6e-55 ylxM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
MEDLAEOO_01924 4.9e-228 ffh 3.6.5.4 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MEDLAEOO_01925 7.6e-45 rpsP J Belongs to the bacterial ribosomal protein bS16 family
MEDLAEOO_01926 3.4e-94 rimM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MEDLAEOO_01927 3.2e-135 trmD 2.1.1.228, 4.6.1.12 J Belongs to the RNA methyltransferase TrmD family
MEDLAEOO_01928 1.1e-56 rplS J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
MEDLAEOO_01929 2.9e-247 mntH P H( )-stimulated, divalent metal cation uptake system
MEDLAEOO_01930 2.4e-45 yitW S Iron-sulfur cluster assembly protein
MEDLAEOO_01931 2e-266 sufB O assembly protein SufB
MEDLAEOO_01932 2.4e-59 nifU C SUF system FeS assembly protein, NifU family
MEDLAEOO_01933 5.3e-178 sufS 2.8.1.7, 4.4.1.16 E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MEDLAEOO_01934 3.5e-174 sufD O FeS assembly protein SufD
MEDLAEOO_01935 2.8e-140 sufC O FeS assembly ATPase SufC
MEDLAEOO_01936 7.4e-42 C 2Fe-2S iron-sulfur cluster binding domain
MEDLAEOO_01937 7e-87 gtcA S Teichoic acid glycosylation protein
MEDLAEOO_01938 4.1e-80 fld C Flavodoxin
MEDLAEOO_01939 1.4e-163 map 3.4.11.18 E Methionine Aminopeptidase
MEDLAEOO_01940 8e-163 yihY S Belongs to the UPF0761 family
MEDLAEOO_01941 2.1e-168 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
MEDLAEOO_01942 5.6e-214 atoB 1.1.1.88, 2.3.1.9 I Belongs to the thiolase family
MEDLAEOO_01943 3.6e-215 mvaS 2.3.3.10 I Hydroxymethylglutaryl-CoA synthase
MEDLAEOO_01944 7.4e-120 3.6.1.55 F NUDIX domain
MEDLAEOO_01945 1.8e-243 brnQ U Component of the transport system for branched-chain amino acids
MEDLAEOO_01946 0.0 L Plasmid pRiA4b ORF-3-like protein
MEDLAEOO_01947 3.2e-65 K HxlR family
MEDLAEOO_01948 3.9e-47
MEDLAEOO_01949 1.4e-212 4.2.1.6, 5.1.2.2 M Mandelate racemase muconate lactonizing enzyme
MEDLAEOO_01950 2.8e-61 tpx 1.11.1.15 O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
MEDLAEOO_01951 1.3e-07 S Protein of unknown function (DUF3021)
MEDLAEOO_01952 3.9e-58
MEDLAEOO_01953 6.9e-136 K helix_turn _helix lactose operon repressor
MEDLAEOO_01954 3.8e-112 tal 2.2.1.2 H Transaldolase/Fructose-6-phosphate aldolase
MEDLAEOO_01955 1.4e-269 G PTS system mannose/fructose/sorbose family IID component
MEDLAEOO_01956 5.2e-53 2.7.1.191 G PTS system fructose IIA component
MEDLAEOO_01957 1.6e-77 2.7.1.191 G PTS system sorbose subfamily IIB component
MEDLAEOO_01959 5.3e-41
MEDLAEOO_01960 1.4e-76 K DNA-templated transcription, initiation
MEDLAEOO_01961 1.1e-25
MEDLAEOO_01962 2.1e-144 3.6.4.12 S PD-(D/E)XK nuclease family transposase
MEDLAEOO_01963 6.7e-19 3.6.4.12 S PD-(D/E)XK nuclease family transposase
MEDLAEOO_01964 1.7e-100 S SLAP domain
MEDLAEOO_01965 4.3e-40 S Protein of unknown function (DUF2922)
MEDLAEOO_01966 5.5e-30
MEDLAEOO_01967 1.5e-36 oppA E ABC transporter substrate-binding protein
MEDLAEOO_01969 1.4e-31 O OsmC-like protein
MEDLAEOO_01970 3.8e-80 coaA 2.7.1.33 F Pantothenic acid kinase
MEDLAEOO_01971 3.2e-75 S ECF transporter, substrate-specific component
MEDLAEOO_01972 1.5e-54 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MEDLAEOO_01973 3.7e-144 gltC_1 3.1.3.48 K LysR substrate binding domain
MEDLAEOO_01974 5.8e-151 2.8.3.1 I Coenzyme A transferase
MEDLAEOO_01975 1.6e-82 2.8.3.1 I Coenzyme A transferase
MEDLAEOO_01976 5.1e-106 fabK 1.3.1.9 S Nitronate monooxygenase
MEDLAEOO_01978 8.8e-62 yodB K Transcriptional regulator, HxlR family
MEDLAEOO_01979 5e-134 spoU 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MEDLAEOO_01980 2.9e-44 acyP 3.6.1.7 C Belongs to the acylphosphatase family
MEDLAEOO_01981 2.2e-163 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
MEDLAEOO_01982 1.5e-72 S Aminoacyl-tRNA editing domain
MEDLAEOO_01983 1.2e-54 S Abi-like protein
MEDLAEOO_01984 8e-224 S SLAP domain
MEDLAEOO_01985 3.9e-128 S CAAX protease self-immunity
MEDLAEOO_01986 2.4e-128 S cog cog1373
MEDLAEOO_01987 1.4e-109 yniG EGP Major facilitator Superfamily
MEDLAEOO_01988 5.4e-237 L transposase, IS605 OrfB family
MEDLAEOO_01989 1.2e-76 yniG EGP Major facilitator Superfamily
MEDLAEOO_01990 4.9e-35
MEDLAEOO_01992 1.3e-42
MEDLAEOO_01993 1.9e-75 M LysM domain
MEDLAEOO_01994 1.2e-49 S Belongs to the short-chain dehydrogenases reductases (SDR) family
MEDLAEOO_01995 7e-135 adh 1.1.1.1, 1.1.1.14 E alcohol dehydrogenase
MEDLAEOO_01996 9.8e-69 GM NAD(P)H-binding
MEDLAEOO_01997 8.9e-34 S Domain of unknown function (DUF4440)
MEDLAEOO_01998 6.6e-90 K LysR substrate binding domain
MEDLAEOO_02000 3.3e-45 K Tetracycline repressor, C-terminal all-alpha domain
MEDLAEOO_02001 3.2e-79 S X-Pro dipeptidyl-peptidase (S15 family)
MEDLAEOO_02002 7.7e-10 C Flavodoxin
MEDLAEOO_02003 1.5e-18 S CRISPR-associated protein (Cas_Csn2)
MEDLAEOO_02004 1.2e-154 yqfL 2.7.11.33, 2.7.4.28 F Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation
MEDLAEOO_02005 2e-22 rpsU J Belongs to the bacterial ribosomal protein bS21 family
MEDLAEOO_02006 3.5e-71 yqeY S YqeY-like protein
MEDLAEOO_02007 1.1e-175 phoH T phosphate starvation-inducible protein PhoH
MEDLAEOO_02008 2.2e-93 ybeY 2.6.99.2, 3.5.4.5 S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MEDLAEOO_02009 2.1e-168 era S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MEDLAEOO_02010 4.4e-135 recO L Involved in DNA repair and RecF pathway recombination
MEDLAEOO_02011 4.6e-179 glyQ 6.1.1.14 J glycyl-tRNA synthetase alpha subunit
MEDLAEOO_02012 0.0 glyS 6.1.1.14 J Glycyl-tRNA synthetase beta subunit
MEDLAEOO_02013 0.0 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
MEDLAEOO_02014 9.9e-200 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
MEDLAEOO_02015 1.4e-127 S Peptidase family M23
MEDLAEOO_02016 4.8e-81 mutT 3.6.1.55 F NUDIX domain
MEDLAEOO_02017 3.5e-123 trmK 2.1.1.217 S SAM-dependent methyltransferase
MEDLAEOO_02018 1.4e-152 yqfO 3.5.4.16 S Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MEDLAEOO_02019 1.7e-240 pepT 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
MEDLAEOO_02020 1.4e-60 yvoA_1 K Transcriptional regulator, GntR family
MEDLAEOO_02021 9.6e-124 skfE V ATPases associated with a variety of cellular activities
MEDLAEOO_02022 4.5e-141
MEDLAEOO_02023 5.1e-137
MEDLAEOO_02024 6.7e-145
MEDLAEOO_02025 1.4e-26
MEDLAEOO_02026 3.9e-104 lepB 3.4.21.89 U Belongs to the peptidase S26 family
MEDLAEOO_02027 7.5e-143
MEDLAEOO_02028 9.7e-169
MEDLAEOO_02029 8.3e-265 rsmF 2.1.1.176 J NOL1 NOP2 sun family protein
MEDLAEOO_02030 1.3e-116 3.1.3.102, 3.1.3.104, 3.1.3.23 G Sucrose-6F-phosphate phosphohydrolase
MEDLAEOO_02031 6.9e-184 fni 1.1.1.88, 5.3.3.2 C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
MEDLAEOO_02032 2.1e-202 mvaK2 2.7.1.36, 2.7.1.43, 2.7.4.2 I phosphomevalonate kinase
MEDLAEOO_02033 1.4e-178 mvaD 4.1.1.33 I diphosphomevalonate decarboxylase
MEDLAEOO_02034 4.8e-136 mvk 1.1.1.88, 2.3.3.10, 2.7.1.36 I GHMP kinases N terminal domain
MEDLAEOO_02035 0.0 rexB 3.1.21.3, 3.6.4.12 L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' - 3' nuclease activity
MEDLAEOO_02036 0.0 addA 3.6.4.12 L ATP-dependent helicase nuclease subunit A
MEDLAEOO_02037 0.0 dinG 2.7.7.7, 3.6.4.12 L helicase involved in DNA repair and perhaps also replication
MEDLAEOO_02038 2.4e-89 ypmB S Protein conserved in bacteria
MEDLAEOO_02039 5.8e-260 asnS 6.1.1.22 J Asparaginyl-tRNA synthetase
MEDLAEOO_02040 1.3e-114 dnaD L DnaD domain protein
MEDLAEOO_02041 2.7e-114 nth 4.2.99.18 L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MEDLAEOO_02042 0.0 ponA 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein 1A
MEDLAEOO_02043 4.5e-117 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
MEDLAEOO_02044 1e-107 ypsA S Belongs to the UPF0398 family
MEDLAEOO_02045 1.1e-68 gpsB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
MEDLAEOO_02046 3.6e-218 rlmL 2.1.1.173, 2.1.1.264 L Belongs to the methyltransferase superfamily
MEDLAEOO_02047 1e-242 cpdA S Calcineurin-like phosphoesterase
MEDLAEOO_02048 3.4e-79
MEDLAEOO_02049 1.9e-115 rdgB 3.6.1.66, 5.1.1.3 F Ham1 family
MEDLAEOO_02050 1.3e-71 K Helix-turn-helix domain, rpiR family
MEDLAEOO_02051 4.1e-21 K Helix-turn-helix domain, rpiR family
MEDLAEOO_02052 4.9e-82 rarA L MgsA AAA+ ATPase C terminal
MEDLAEOO_02053 4.3e-226 2.7.1.207 G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
MEDLAEOO_02055 1.8e-104 3.2.2.20 K acetyltransferase
MEDLAEOO_02056 2.3e-93 hpt 2.4.2.8 F Belongs to the purine pyrimidine phosphoribosyltransferase family
MEDLAEOO_02057 6.4e-243 cydA 1.10.3.14 C ubiquinol oxidase
MEDLAEOO_02058 8.2e-177 cydB 1.10.3.14 C Cytochrome d ubiquinol oxidase subunit II
MEDLAEOO_02059 0.0 cydD CO ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydD
MEDLAEOO_02060 1.9e-269 cydD CO ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MEDLAEOO_02061 8.3e-128 menG 2.1.1.163, 2.1.1.201 H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)
MEDLAEOO_02062 1.5e-304 mutS2 L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
MEDLAEOO_02063 5.4e-203 xerS L Belongs to the 'phage' integrase family
MEDLAEOO_02064 4.1e-67
MEDLAEOO_02065 8e-111 XK27_00160 S Domain of unknown function (DUF5052)
MEDLAEOO_02066 5.8e-211 M Glycosyl hydrolases family 25
MEDLAEOO_02067 1.1e-126 S Alpha/beta hydrolase family
MEDLAEOO_02068 1.3e-156 epsV 2.7.8.12 S glycosyl transferase family 2
MEDLAEOO_02069 9.8e-140 ypuA S Protein of unknown function (DUF1002)
MEDLAEOO_02070 6.7e-147 rnhA 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MEDLAEOO_02071 1.6e-182 S Alpha/beta hydrolase of unknown function (DUF915)
MEDLAEOO_02072 1.2e-282 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MEDLAEOO_02073 9.3e-86
MEDLAEOO_02074 2.5e-226 pbuG S permease
MEDLAEOO_02075 9.7e-146 S haloacid dehalogenase-like hydrolase
MEDLAEOO_02076 2e-225 S cog cog1373
MEDLAEOO_02077 6.1e-61 K Transcriptional regulator
MEDLAEOO_02078 1.3e-94 K Transcriptional regulator
MEDLAEOO_02079 1.8e-48 1.1.1.100 S Enoyl-(Acyl carrier protein) reductase
MEDLAEOO_02080 3.1e-16 S PemK-like, MazF-like toxin of type II toxin-antitoxin system
MEDLAEOO_02081 2.5e-40 relB L Addiction module antitoxin, RelB DinJ family
MEDLAEOO_02083 1.9e-98 L Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
MEDLAEOO_02085 1.2e-60 L Putative transposase DNA-binding domain
MEDLAEOO_02086 2.3e-142 L Belongs to the 'phage' integrase family
MEDLAEOO_02087 1.3e-273 pipD E Dipeptidase
MEDLAEOO_02088 1.5e-102 devA 3.6.3.25 V ABC transporter, ATP-binding protein
MEDLAEOO_02089 3.3e-176 hrtB V ABC transporter permease
MEDLAEOO_02090 3.2e-92 ygfC K Bacterial regulatory proteins, tetR family
MEDLAEOO_02091 3.5e-111 G phosphoglycerate mutase
MEDLAEOO_02092 4.1e-141 aroD S Alpha/beta hydrolase family
MEDLAEOO_02093 2.2e-142 S Belongs to the UPF0246 family
MEDLAEOO_02094 2.8e-216 coaBC 4.1.1.36, 6.3.2.5 H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MEDLAEOO_02095 4.8e-34 S reductase
MEDLAEOO_02096 4.4e-39 S reductase
MEDLAEOO_02097 6e-32 S reductase
MEDLAEOO_02098 1.3e-148 yxeH S hydrolase
MEDLAEOO_02099 6.8e-181 gyaR 1.1.1.26, 2.7.1.165 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MEDLAEOO_02100 1.1e-243 yfnA E Amino Acid
MEDLAEOO_02101 2.1e-78 2.7.13.3 T GHKL domain
MEDLAEOO_02102 2.9e-79 K LytTr DNA-binding domain
MEDLAEOO_02103 0.0 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
MEDLAEOO_02104 5.7e-43 2.4.1.33 V HlyD family secretion protein
MEDLAEOO_02106 1e-20 S Enterocin A Immunity
MEDLAEOO_02107 5.4e-113
MEDLAEOO_02108 1.7e-139
MEDLAEOO_02109 6.9e-100 V ATPases associated with a variety of cellular activities
MEDLAEOO_02110 3.7e-146 ykuT M mechanosensitive ion channel
MEDLAEOO_02111 9.5e-10 WQ51_05790 S protein containing a divergent version of the methyl-accepting chemotaxis-like domain
MEDLAEOO_02112 1.3e-36
MEDLAEOO_02113 4.7e-182 pepA E M42 glutamyl aminopeptidase
MEDLAEOO_02114 2.2e-311 ybiT S ABC transporter, ATP-binding protein
MEDLAEOO_02115 5.9e-174 S Aldo keto reductase
MEDLAEOO_02116 2.7e-138
MEDLAEOO_02117 2.8e-202 steT E amino acid
MEDLAEOO_02118 2.4e-26 steT E amino acid
MEDLAEOO_02119 8.6e-243 steT E amino acid
MEDLAEOO_02120 1.9e-129 yfeJ 6.3.5.2 F glutamine amidotransferase
MEDLAEOO_02121 1.9e-147 glnH ET ABC transporter
MEDLAEOO_02122 1.4e-80 K Transcriptional regulator, MarR family
MEDLAEOO_02123 6.9e-309 XK27_09600 V ABC transporter, ATP-binding protein
MEDLAEOO_02124 0.0 V ABC transporter transmembrane region
MEDLAEOO_02125 1.6e-100 S ABC-type cobalt transport system, permease component
MEDLAEOO_02126 1e-246 G MFS/sugar transport protein
MEDLAEOO_02127 9.8e-39 udk 2.7.1.48 F Zeta toxin
MEDLAEOO_02128 3.8e-46 udk 2.7.1.48 F Zeta toxin
MEDLAEOO_02129 4.8e-134 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
MEDLAEOO_02130 1.2e-146 glnH ET ABC transporter substrate-binding protein
MEDLAEOO_02131 3.7e-90 gluC P ABC transporter permease
MEDLAEOO_02132 4.7e-109 glnP P ABC transporter permease
MEDLAEOO_02133 1.1e-164 S Protein of unknown function (DUF2974)
MEDLAEOO_02134 5.6e-86
MEDLAEOO_02135 6.3e-212 S Uncharacterized protein conserved in bacteria (DUF2325)
MEDLAEOO_02136 1.3e-235 G Bacterial extracellular solute-binding protein
MEDLAEOO_02137 7.7e-162 2.7.7.12 C Domain of unknown function (DUF4931)
MEDLAEOO_02138 3.5e-166 rbsK 2.7.1.15 H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MEDLAEOO_02139 1.3e-125 rpiA 2.7.1.12, 2.7.1.15, 5.3.1.6 G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MEDLAEOO_02140 0.0 kup P Transport of potassium into the cell
MEDLAEOO_02141 9.1e-175 rihB 3.2.2.1 F Nucleoside
MEDLAEOO_02142 2.8e-134 ydhQ K UbiC transcription regulator-associated domain protein
MEDLAEOO_02143 1.2e-154 S hydrolase
MEDLAEOO_02144 2.5e-59 S Enterocin A Immunity
MEDLAEOO_02145 3.1e-136 glcR K DeoR C terminal sensor domain
MEDLAEOO_02146 0.0 xfp 4.1.2.22, 4.1.2.9 G Phosphoketolase
MEDLAEOO_02147 2e-160 rssA S Phospholipase, patatin family
MEDLAEOO_02148 5.4e-147 S hydrolase
MEDLAEOO_02149 0.0 glvC 2.7.1.199, 2.7.1.208, 2.7.1.211 G phosphotransferase system, EIIB
MEDLAEOO_02150 4.1e-147 glvR K Helix-turn-helix domain, rpiR family
MEDLAEOO_02151 1.6e-80
MEDLAEOO_02152 2.9e-87 pts23A G phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1
MEDLAEOO_02153 2.1e-39
MEDLAEOO_02154 3.9e-119 C nitroreductase
MEDLAEOO_02155 1.7e-249 yhdP S Transporter associated domain
MEDLAEOO_02156 3.4e-103 hpt 2.4.2.8 F Belongs to the purine pyrimidine phosphoribosyltransferase family
MEDLAEOO_02157 0.0 1.3.5.4 C FAD binding domain
MEDLAEOO_02158 3.8e-88 L PFAM transposase, IS4 family protein
MEDLAEOO_02159 1.2e-49 L PFAM transposase, IS4 family protein
MEDLAEOO_02160 4.8e-213 1.3.5.4 C FAD binding domain
MEDLAEOO_02161 3.4e-126 1.3.5.4 C FAD binding domain
MEDLAEOO_02162 2.2e-10 S Bacteriophage abortive infection AbiH
MEDLAEOO_02163 3.5e-309 sacB 2.4.1.10, 2.4.1.9, 3.2.1.26 GH32,GH68 M Levansucrase/Invertase
MEDLAEOO_02167 2.5e-114 adh 1.1.1.1, 1.1.1.14 E alcohol dehydrogenase
MEDLAEOO_02168 7.2e-183 3.6.4.12 K Putative ATP-dependent DNA helicase recG C-terminal
MEDLAEOO_02169 4.3e-52 K helix_turn_helix gluconate operon transcriptional repressor
MEDLAEOO_02170 4.6e-155 crtI 1.3.99.23, 5.2.1.13 Q HI0933-like protein
MEDLAEOO_02171 2.6e-65 C 2Fe-2S iron-sulfur cluster binding domain
MEDLAEOO_02172 0.0 kup P Transport of potassium into the cell
MEDLAEOO_02173 7.3e-74
MEDLAEOO_02174 2.1e-45 S PFAM Archaeal ATPase
MEDLAEOO_02176 3.7e-58 T PemK-like, MazF-like toxin of type II toxin-antitoxin system
MEDLAEOO_02177 5.9e-45
MEDLAEOO_02182 3.2e-24 S Domain of unknown function (DUF771)
MEDLAEOO_02183 8.9e-32 K Helix-turn-helix domain
MEDLAEOO_02184 1.2e-21 XK27_07105 K Helix-turn-helix XRE-family like proteins
MEDLAEOO_02185 1.2e-23 K Helix-turn-helix domain
MEDLAEOO_02186 5e-08 S Pfam:DUF955
MEDLAEOO_02187 1.4e-153 L Belongs to the 'phage' integrase family
MEDLAEOO_02188 7e-108 S Protein of unknown function (DUF1211)
MEDLAEOO_02189 2.4e-273 lsa S ABC transporter
MEDLAEOO_02190 2.8e-24 S Alpha beta hydrolase
MEDLAEOO_02191 1.9e-237 brnQ U Component of the transport system for branched-chain amino acids
MEDLAEOO_02192 2.6e-61 M Glycosyl hydrolases family 25
MEDLAEOO_02193 1.3e-61 M Glycosyl hydrolases family 25
MEDLAEOO_02194 2.8e-211 yfmL 3.6.4.13 L DEAD DEAH box helicase
MEDLAEOO_02195 4.7e-249 celB G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
MEDLAEOO_02197 2e-216 mnaA 5.1.3.14 G Belongs to the UDP-N-acetylglucosamine 2-epimerase family
MEDLAEOO_02198 2.4e-289 citF 2.8.3.10 H Citrate (pro-3S)-lyase alpha chain
MEDLAEOO_02199 2.4e-167 citE 4.1.3.25, 4.1.3.34 G Belongs to the HpcH HpaI aldolase family
MEDLAEOO_02200 1.2e-43 citD C Covalent carrier of the coenzyme of citrate lyase
MEDLAEOO_02201 6.9e-195 citC 6.2.1.22 H Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
MEDLAEOO_02202 3.8e-153 ydjP I Alpha/beta hydrolase family
MEDLAEOO_02204 3.2e-139 ribD 1.1.1.193, 3.5.4.26 H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MEDLAEOO_02205 8.7e-86 ribE 2.5.1.9, 3.5.4.25, 4.1.99.12 H Riboflavin synthase
MEDLAEOO_02206 4.5e-227 ribBA 3.5.4.25, 4.1.99.12 H Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate
MEDLAEOO_02207 2.8e-79 ribH 2.5.1.78 H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
MEDLAEOO_02208 1.6e-77 ybhL S Belongs to the BI1 family
MEDLAEOO_02209 3.6e-39 C FMN_bind
MEDLAEOO_02210 1.5e-81
MEDLAEOO_02211 1.3e-176 iunH 3.2.2.1 F inosine-uridine preferring nucleoside hydrolase
MEDLAEOO_02212 2e-85 alkD L DNA alkylation repair enzyme
MEDLAEOO_02213 1.2e-293 celA 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
MEDLAEOO_02214 4.5e-73 K UTRA domain
MEDLAEOO_02215 1.3e-122 sdaAB 4.3.1.17 E Serine dehydratase beta chain
MEDLAEOO_02216 3.8e-154 sdaAA 4.3.1.17 E L-serine dehydratase, iron-sulfur-dependent, alpha subunit
MEDLAEOO_02217 9.7e-52 S Iron-sulfur cluster assembly protein
MEDLAEOO_02218 6.9e-116 dapE 3.5.1.18 E succinyl-diaminopimelate desuccinylase
MEDLAEOO_02219 5e-48 dapE 3.5.1.18 E succinyl-diaminopimelate desuccinylase
MEDLAEOO_02220 3.7e-243 lctO C L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

eggNOG-mapper v2 (Database: eggNOG v5.0, Jul. 2018 release)