ORF_ID e_value Gene_name EC_number CAZy COGs Description
HGMOLFCO_00001 5.1e-136 E GDSL-like Lipase/Acylhydrolase family
HGMOLFCO_00002 7.4e-123 C nitroreductase
HGMOLFCO_00003 1.9e-175 rihA 3.2.2.1 F Inosine-uridine preferring nucleoside hydrolase
HGMOLFCO_00004 1.2e-11 sucD 6.2.1.5 C CoA-ligase
HGMOLFCO_00005 4.1e-203 allD 1.1.1.350 C Belongs to the LDH2 MDH2 oxidoreductase family
HGMOLFCO_00006 1.7e-98 allC 3.5.1.6, 3.5.1.87, 3.5.3.9 E Peptidase family M20/M25/M40
HGMOLFCO_00007 8.3e-135 allB 3.5.2.5 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
HGMOLFCO_00008 2e-64 pucR QT Purine catabolism regulatory protein-like family
HGMOLFCO_00009 1.2e-21 pucG 2.6.1.112, 2.6.1.44, 2.6.1.45, 2.6.1.51 E Aminotransferase class-V
HGMOLFCO_00010 1.1e-59 pucG 2.6.1.112, 2.6.1.44, 2.6.1.45, 2.6.1.51 E Aminotransferase class-V
HGMOLFCO_00011 2.6e-26 pucG 2.6.1.112, 2.6.1.44, 2.6.1.45, 2.6.1.51 E Aminotransferase class-V
HGMOLFCO_00012 1.7e-179 1.1.1.26 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HGMOLFCO_00013 5.2e-102 S membrane transporter protein
HGMOLFCO_00014 1.4e-89 pgpA 3.1.3.27 I Phosphatidylglycerophosphatase A
HGMOLFCO_00015 1.7e-193 V Beta-lactamase
HGMOLFCO_00016 9.2e-228
HGMOLFCO_00018 6.3e-154 S Alpha/beta hydrolase of unknown function (DUF915)
HGMOLFCO_00019 0.0 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HGMOLFCO_00020 6e-15 S ABC-type transport system involved in multi-copper enzyme maturation permease component
HGMOLFCO_00021 5.1e-08 S ABC-2 family transporter protein
HGMOLFCO_00022 7.8e-52 T Transcriptional regulatory protein, C terminal
HGMOLFCO_00023 1.6e-63 T His Kinase A (phosphoacceptor) domain
HGMOLFCO_00024 2.5e-54 C FMN binding
HGMOLFCO_00025 3.4e-202 ribD 1.1.1.193, 3.5.4.26 H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HGMOLFCO_00026 9.1e-107 ribE 2.5.1.9, 3.5.4.25, 4.1.99.12 H Riboflavin synthase
HGMOLFCO_00027 9.2e-228 ribBA 3.5.4.25, 4.1.99.12 H Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate
HGMOLFCO_00028 1.9e-80 ribH 2.5.1.78 H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
HGMOLFCO_00029 2.1e-79 K 2 iron, 2 sulfur cluster binding
HGMOLFCO_00030 7.1e-269 K COG COG0846 NAD-dependent protein deacetylases, SIR2 family
HGMOLFCO_00031 5.3e-220 serA 1.1.1.399, 1.1.1.95 EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HGMOLFCO_00032 8.3e-204 serC 2.6.1.52 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HGMOLFCO_00033 9.3e-112 C aldo keto reductase
HGMOLFCO_00034 1.9e-112 3.1.3.73 G phosphoglycerate mutase
HGMOLFCO_00035 3.3e-09
HGMOLFCO_00036 0.0 lepA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
HGMOLFCO_00037 1.5e-200 hisC 2.6.1.9 E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HGMOLFCO_00038 9.9e-52 hisE 3.5.4.19, 3.6.1.31, 5.3.1.16 E phosphoribosyl-ATP diphosphatase activity
HGMOLFCO_00039 9.7e-39 ykuJ S Protein of unknown function (DUF1797)
HGMOLFCO_00040 1.9e-181 mprF I Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HGMOLFCO_00041 7.7e-199 cpoA GT4 M Glycosyltransferase, group 1 family protein
HGMOLFCO_00042 1.3e-229 mgs 2.4.1.337 GT4 M Glycosyltransferase, group 1 family protein
HGMOLFCO_00043 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HGMOLFCO_00044 1.4e-38 ptsH G phosphocarrier protein HPR
HGMOLFCO_00046 0.0 clpE O Belongs to the ClpA ClpB family
HGMOLFCO_00047 2.4e-127 3.6.1.13, 3.6.1.55 F NUDIX domain
HGMOLFCO_00048 3.7e-110 pncA Q Isochorismatase family
HGMOLFCO_00049 6.6e-265 pncB 6.3.4.21 F Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HGMOLFCO_00050 1.7e-97 S Pfam:DUF3816
HGMOLFCO_00051 1e-141 manA 1.14.13.81, 5.3.1.8, 5.4.2.8 G MucBP domain
HGMOLFCO_00052 1.9e-136 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HGMOLFCO_00053 6.5e-162 EG EamA-like transporter family
HGMOLFCO_00054 6e-246 yxbA 6.3.1.12 S ATP-grasp enzyme
HGMOLFCO_00055 4.7e-61 L Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
HGMOLFCO_00056 8.5e-21 gshF 6.3.2.2 H Belongs to the glutamate--cysteine ligase type 1 family
HGMOLFCO_00057 3.9e-226 gshF 6.3.2.2 H Belongs to the glutamate--cysteine ligase type 1 family
HGMOLFCO_00059 1.3e-36 ywnB S NAD(P)H-binding
HGMOLFCO_00060 7.2e-66 yjcE P Sodium proton antiporter
HGMOLFCO_00061 5.9e-76
HGMOLFCO_00062 1.3e-184
HGMOLFCO_00063 9e-127 narI 1.7.5.1 C Nitrate reductase
HGMOLFCO_00064 1.2e-101 narJ C Nitrate reductase delta subunit
HGMOLFCO_00065 0.0 narH 1.7.5.1 C Respiratory nitrate reductase beta C-terminal
HGMOLFCO_00066 0.0 narG 1.7.5.1 C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HGMOLFCO_00067 1.4e-189 moeB 2.7.7.73, 2.7.7.80 H ThiF family
HGMOLFCO_00068 1.9e-86 moaB 2.7.7.75 H May be involved in the biosynthesis of molybdopterin
HGMOLFCO_00069 1.2e-230 moeA 2.10.1.1 H MoeA N-terminal region (domain I and II)
HGMOLFCO_00070 9.3e-85 moaC 4.6.1.17 H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)
HGMOLFCO_00071 1.1e-98 mobA 2.7.7.77 H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
HGMOLFCO_00072 4.2e-40
HGMOLFCO_00073 1.4e-77 nreA T GAF domain
HGMOLFCO_00074 1.6e-183 comP 2.7.13.3 F Sensor histidine kinase
HGMOLFCO_00075 4e-116 nreC K PFAM regulatory protein LuxR
HGMOLFCO_00076 6e-39
HGMOLFCO_00077 8.8e-184
HGMOLFCO_00078 9.7e-169 hepT 2.5.1.30, 2.5.1.90 H geranyltranstransferase activity
HGMOLFCO_00080 6.7e-133 menG 2.1.1.163, 2.1.1.201 H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)
HGMOLFCO_00081 2.9e-162 hipB K Helix-turn-helix
HGMOLFCO_00082 1.5e-58 yitW S Iron-sulfur cluster assembly protein
HGMOLFCO_00083 3.6e-216 narK P Major Facilitator Superfamily
HGMOLFCO_00084 7.8e-196 moaA 4.1.99.22 H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HGMOLFCO_00085 6.4e-35 moaD 2.8.1.12 H ThiS family
HGMOLFCO_00086 2.2e-72 moaE 2.8.1.12 H MoaE protein
HGMOLFCO_00087 1.5e-170 fecD P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HGMOLFCO_00088 1e-142 fecE 3.6.3.34 HP AAA domain, putative AbiEii toxin, Type IV TA system
HGMOLFCO_00089 4.2e-228 ndh 1.6.99.3 C NADH dehydrogenase
HGMOLFCO_00090 8e-54 yitW S Iron-sulfur cluster assembly protein
HGMOLFCO_00091 4.7e-19 M1-755 S Domain of unknown function (DUF1858)
HGMOLFCO_00092 9.5e-258 XK27_04775 S PAS domain
HGMOLFCO_00093 2.4e-142 EG EamA-like transporter family
HGMOLFCO_00094 4e-68 paiA 2.3.1.57 K Acetyltransferase (GNAT) domain
HGMOLFCO_00095 4.2e-74 O OsmC-like protein
HGMOLFCO_00096 1.6e-76 K Transcriptional regulator
HGMOLFCO_00097 3e-162 proX M ABC transporter, substrate-binding protein, QAT family
HGMOLFCO_00098 1.8e-108 proWZ P ABC transporter permease
HGMOLFCO_00099 9.3e-141 proV E ABC transporter, ATP-binding protein
HGMOLFCO_00100 3.1e-102 proW P ABC transporter, permease protein
HGMOLFCO_00101 7.2e-183 C Zinc-binding dehydrogenase
HGMOLFCO_00102 6.3e-196 bdhA 1.1.1.303, 1.1.1.4 C Zinc-binding dehydrogenase
HGMOLFCO_00103 2.1e-224 4.4.1.8 E Aminotransferase, class I
HGMOLFCO_00104 3.6e-179 pva3 3.5.1.24 M Linear amide C-N hydrolase, choloylglycine hydrolase family protein
HGMOLFCO_00105 7.8e-202 xerS L Belongs to the 'phage' integrase family
HGMOLFCO_00106 9e-62 ywkB S Membrane transport protein
HGMOLFCO_00107 2.8e-235 icd 1.1.1.42 C Isocitrate/isopropylmalate dehydrogenase
HGMOLFCO_00108 1.7e-151 pdxK 2.7.1.35 H Phosphomethylpyrimidine kinase
HGMOLFCO_00109 2.6e-80 hmpT S ECF-type riboflavin transporter, S component
HGMOLFCO_00110 4.7e-165 1.1.1.346 C Aldo keto reductase
HGMOLFCO_00111 7.5e-161 S DUF218 domain
HGMOLFCO_00114 6.3e-96 K Acetyltransferase (GNAT) domain
HGMOLFCO_00115 4.8e-162 I alpha/beta hydrolase fold
HGMOLFCO_00116 2.2e-125 S Phage minor capsid protein 2
HGMOLFCO_00118 1.3e-148 2.6.1.1 E Aminotransferase
HGMOLFCO_00119 5.3e-17 mleP3 S Membrane transport protein
HGMOLFCO_00121 2.6e-166 rbsK 2.7.1.15 H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HGMOLFCO_00122 2.5e-161 glxR 1.1.1.31, 1.1.1.60 I Dehydrogenase
HGMOLFCO_00123 2.5e-183 fruR3 K Transcriptional regulator, LacI family
HGMOLFCO_00124 1.1e-103 wecD3 K Acetyltransferase (GNAT) family
HGMOLFCO_00125 1.9e-68 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HGMOLFCO_00126 2.2e-55 crcB D Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HGMOLFCO_00127 2.9e-54 crcB U Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HGMOLFCO_00128 2.6e-280 arlS 2.7.13.3 T Histidine kinase
HGMOLFCO_00129 5.6e-121 K response regulator
HGMOLFCO_00130 7.2e-28 rpmF J Belongs to the bacterial ribosomal protein bL32 family
HGMOLFCO_00131 3.5e-97 yceD S Uncharacterized ACR, COG1399
HGMOLFCO_00132 6.4e-215 ylbM S Belongs to the UPF0348 family
HGMOLFCO_00133 5.4e-141 yqeM Q Methyltransferase
HGMOLFCO_00134 1.6e-58 rsfS J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
HGMOLFCO_00135 7.3e-112 nadD 2.7.6.3, 2.7.7.18 H Hydrolase, HD family
HGMOLFCO_00136 4.1e-94 nadD 2.7.7.18, 3.6.1.55 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HGMOLFCO_00137 1.3e-48 yhbY J RNA-binding protein
HGMOLFCO_00138 2.6e-216 yqeH S Ribosome biogenesis GTPase YqeH
HGMOLFCO_00139 2.2e-96 yqeG S HAD phosphatase, family IIIA
HGMOLFCO_00141 4.2e-19 yoaK S Protein of unknown function (DUF1275)
HGMOLFCO_00142 6.6e-57 rplT J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HGMOLFCO_00143 1.5e-26 rpmI J Belongs to the bacterial ribosomal protein bL35 family
HGMOLFCO_00144 1.7e-85 infC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HGMOLFCO_00145 2.5e-172 dnaI L Primosomal protein DnaI
HGMOLFCO_00146 3.6e-252 dnaB L replication initiation and membrane attachment
HGMOLFCO_00147 8.5e-81 nrdR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HGMOLFCO_00148 3.5e-106 coaE 2.7.1.24 F Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HGMOLFCO_00149 2.1e-162 fpg 3.2.2.23, 4.2.99.18 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
HGMOLFCO_00150 0.0 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HGMOLFCO_00151 2.9e-139 aroD S Serine hydrolase (FSH1)
HGMOLFCO_00152 1.8e-114 ybhL S Belongs to the BI1 family
HGMOLFCO_00153 1.4e-250 mpl 6.3.2.4, 6.3.2.45, 6.3.2.8 M Belongs to the MurCDEF family
HGMOLFCO_00154 2e-117 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HGMOLFCO_00155 6.5e-56 ytpP 2.7.1.180, 5.3.4.1 CO Thioredoxin
HGMOLFCO_00156 5.1e-59 ytzB S Small secreted protein
HGMOLFCO_00157 1.8e-124 trmB 2.1.1.297, 2.1.1.33 J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
HGMOLFCO_00158 1.3e-210 ecsB U ABC transporter
HGMOLFCO_00159 3e-133 ecsA V ABC transporter, ATP-binding protein
HGMOLFCO_00160 4.1e-77 hit FG histidine triad
HGMOLFCO_00162 3.1e-149 prsA 5.2.1.8 M Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins
HGMOLFCO_00163 9.7e-180 yhaM S Metal dependent phosphohydrolases with conserved 'HD' motif.
HGMOLFCO_00164 9.8e-56 yheA S Belongs to the UPF0342 family
HGMOLFCO_00165 0.0 pbp2A 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
HGMOLFCO_00166 0.0 argS 6.1.1.19 J Arginyl-tRNA synthetase
HGMOLFCO_00168 1.7e-36
HGMOLFCO_00170 1.8e-201 folP 2.5.1.15 H dihydropteroate synthase
HGMOLFCO_00171 2.6e-106 xtp 2.5.1.15, 3.6.1.66 F Ham1 family
HGMOLFCO_00172 2.2e-243 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
HGMOLFCO_00173 3.1e-104 folE 2.7.6.3, 3.5.4.16 F GTP cyclohydrolase 1
HGMOLFCO_00174 1.5e-94 folK 1.13.11.81, 2.5.1.15, 2.7.6.3, 3.5.4.16, 4.1.2.25, 5.1.99.8 H 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)
HGMOLFCO_00175 1.9e-62 folB 1.13.11.81, 2.5.1.15, 2.7.6.3, 4.1.2.25, 5.1.99.8 H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HGMOLFCO_00176 6.9e-119 S CAAX protease self-immunity
HGMOLFCO_00177 9.9e-183 rbsR K Periplasmic binding proteins and sugar binding domain of LacI family
HGMOLFCO_00178 3.6e-111
HGMOLFCO_00179 8.6e-116 dck 2.7.1.74 F deoxynucleoside kinase
HGMOLFCO_00180 9.7e-163 3.2.1.17 NU Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
HGMOLFCO_00181 4.2e-256 S Putative peptidoglycan binding domain
HGMOLFCO_00182 3.3e-86 uspA T Belongs to the universal stress protein A family
HGMOLFCO_00183 2.9e-273 pepV 3.5.1.18 E dipeptidase PepV
HGMOLFCO_00184 9.8e-155 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HGMOLFCO_00185 2.8e-61 3.2.1.23 S Domain of unknown function DUF302
HGMOLFCO_00186 1.4e-298 ytgP S Polysaccharide biosynthesis protein
HGMOLFCO_00187 2.6e-42
HGMOLFCO_00188 0.0 leuS 6.1.1.4 J Belongs to the class-I aminoacyl-tRNA synthetase family
HGMOLFCO_00189 1e-125 3.1.3.2, 3.1.3.27, 3.1.3.4, 3.1.3.81, 3.6.1.27 I Acid phosphatase homologues
HGMOLFCO_00190 3.4e-225 proA 1.2.1.41 E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HGMOLFCO_00191 3.7e-140 proB 2.7.2.11 F Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HGMOLFCO_00192 1.1e-209 metK 2.5.1.6 H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HGMOLFCO_00193 8.5e-51
HGMOLFCO_00194 6.8e-98 tag 3.2.2.20 L glycosylase
HGMOLFCO_00195 5.8e-253 EGP Major facilitator Superfamily
HGMOLFCO_00196 2.8e-84 perR P Belongs to the Fur family
HGMOLFCO_00197 4.5e-247 cycA E Amino acid permease
HGMOLFCO_00198 4e-22
HGMOLFCO_00200 6.3e-07 tlpA2 L Transposase IS200 like
HGMOLFCO_00201 4.6e-42 rpsO J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HGMOLFCO_00202 2.3e-35 rpsT J Binds directly to 16S ribosomal RNA
HGMOLFCO_00203 1.8e-184 holA 2.7.7.7 L DNA polymerase III delta subunit
HGMOLFCO_00204 0.0 comEC S Competence protein ComEC
HGMOLFCO_00205 3.4e-88 comEB 3.5.4.12 F ComE operon protein 2
HGMOLFCO_00206 3.8e-90 comEA L Competence protein ComEA
HGMOLFCO_00207 4.3e-197 ylbL T Belongs to the peptidase S16 family
HGMOLFCO_00208 9.6e-89 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HGMOLFCO_00209 1.3e-99 rsmD 2.1.1.171 L RNA methyltransferase, RsmD family
HGMOLFCO_00210 1.4e-47 ylbG S Uncharacterized protein conserved in bacteria (DUF2129)
HGMOLFCO_00211 1.5e-214 ftsW D Belongs to the SEDS family
HGMOLFCO_00212 0.0 typA T GTP-binding protein TypA
HGMOLFCO_00213 1.1e-136 suhB 3.1.3.25 G Belongs to the inositol monophosphatase superfamily
HGMOLFCO_00214 2.4e-49 yktA S Belongs to the UPF0223 family
HGMOLFCO_00215 7.5e-103 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
HGMOLFCO_00216 1.2e-74
HGMOLFCO_00217 2.2e-31 ykzG S Belongs to the UPF0356 family
HGMOLFCO_00218 5.8e-188 ytlR 2.7.1.91 I Diacylglycerol kinase catalytic
HGMOLFCO_00219 4.2e-74 spx4 1.20.4.1 P ArsC family
HGMOLFCO_00220 9.4e-178 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HGMOLFCO_00221 0.0 recD 3.1.11.5 L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
HGMOLFCO_00222 1.6e-123 S Repeat protein
HGMOLFCO_00223 4.1e-121 pgm6 5.4.2.11, 5.4.2.12 G phosphoglycerate mutase
HGMOLFCO_00224 4e-170 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
HGMOLFCO_00225 1.3e-306 S amidohydrolase
HGMOLFCO_00226 5.8e-224 mnmA 2.8.1.13 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
HGMOLFCO_00227 3.4e-58 XK27_04120 S Putative amino acid metabolism
HGMOLFCO_00228 1.3e-125 mtnN 3.2.2.9 E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HGMOLFCO_00230 3.8e-96 nudF 3.6.1.13 L ADP-ribose pyrophosphatase
HGMOLFCO_00231 1.2e-32 cspB K Cold shock protein
HGMOLFCO_00232 0.0 ileS 6.1.1.5 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HGMOLFCO_00234 4.8e-112 divIVA D DivIVA domain protein
HGMOLFCO_00235 1.9e-144 ylmH S S4 domain protein
HGMOLFCO_00236 6.8e-41 yggT S YGGT family
HGMOLFCO_00237 2.5e-75 sepF D Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
HGMOLFCO_00238 9e-221 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HGMOLFCO_00239 3.2e-224 ftsA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
HGMOLFCO_00240 8.4e-151 divIB D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
HGMOLFCO_00241 2.8e-202 murG 2.4.1.227, 6.3.2.8 GT28 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HGMOLFCO_00242 9.5e-261 murD 6.3.2.9 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HGMOLFCO_00243 9.1e-178 mraY 2.7.8.13 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HGMOLFCO_00244 0.0 ftsI 3.4.16.4 M Penicillin-binding Protein
HGMOLFCO_00245 7e-09 ftsL D Cell division protein FtsL
HGMOLFCO_00246 1.1e-172 rsmH 2.1.1.199 J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
HGMOLFCO_00247 5.6e-79 mraZ K Belongs to the MraZ family
HGMOLFCO_00248 5.8e-58
HGMOLFCO_00249 1.2e-07 S Protein of unknown function (DUF4044)
HGMOLFCO_00250 0.0 ftsK D Belongs to the FtsK SpoIIIE SftA family
HGMOLFCO_00251 1.5e-94 trmL 2.1.1.207 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
HGMOLFCO_00252 3.3e-163 rrmA 2.1.1.187 H Methyltransferase
HGMOLFCO_00253 1.5e-194 pgl 3.1.1.31 G Lactonase, 7-bladed beta-propeller
HGMOLFCO_00254 8.2e-173 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 G Responsible for synthesis of pseudouridine from uracil
HGMOLFCO_00255 1e-153 nadK 2.7.1.23 F Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HGMOLFCO_00256 6e-123 yjbM 2.7.6.5 S RelA SpoT domain protein
HGMOLFCO_00257 1.8e-113 yjbH Q Thioredoxin
HGMOLFCO_00258 9.4e-205 coiA 3.6.4.12 S Competence protein
HGMOLFCO_00259 4.5e-113 mecA NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
HGMOLFCO_00260 1.7e-69 spxA 1.20.4.1 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
HGMOLFCO_00261 2.8e-16 traP 1.14.99.57, 6.2.1.3 S enzyme involved in biosynthesis of extracellular polysaccharides
HGMOLFCO_00262 2.3e-157 odh 1.5.1.28 C NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain
HGMOLFCO_00263 1.2e-119 5.1.1.13 M racemase activity, acting on amino acids and derivatives
HGMOLFCO_00264 7.8e-261 arcD E Amino acid permease
HGMOLFCO_00265 4.5e-199 ilvE 2.6.1.42 E Branched-chain amino acid aminotransferase
HGMOLFCO_00266 1.3e-55 lacA 2.3.1.18, 2.3.1.79 S Maltose acetyltransferase
HGMOLFCO_00267 4.3e-36 lacA 2.3.1.18, 2.3.1.79 S Maltose acetyltransferase
HGMOLFCO_00268 6.2e-77 yncA 2.3.1.18, 2.3.1.79 S Maltose acetyltransferase
HGMOLFCO_00269 2.4e-84 S Fic/DOC family
HGMOLFCO_00270 1.8e-96 apt 2.4.2.22, 2.4.2.7 F Phosphoribosyl transferase domain
HGMOLFCO_00271 1e-246 EGP Sugar (and other) transporter
HGMOLFCO_00272 3.1e-69 1.4.1.1, 4.3.1.12 E Ornithine cyclodeaminase/mu-crystallin family
HGMOLFCO_00273 1.1e-72 1.4.1.1, 4.3.1.12 E Ornithine cyclodeaminase/mu-crystallin family
HGMOLFCO_00274 7.4e-77 K AsnC family
HGMOLFCO_00275 1e-81 uspA T universal stress protein
HGMOLFCO_00276 2.3e-273 gnd 1.1.1.343, 1.1.1.44 H Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HGMOLFCO_00277 2.6e-288 zwf 1.1.1.363, 1.1.1.49 G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HGMOLFCO_00278 8.8e-207 yeaN P Transporter, major facilitator family protein
HGMOLFCO_00279 1.5e-74 S 3-demethylubiquinone-9 3-methyltransferase
HGMOLFCO_00280 2.4e-83 nrdI F Belongs to the NrdI family
HGMOLFCO_00281 3.6e-252 yhdP S Transporter associated domain
HGMOLFCO_00282 5.2e-90 GM epimerase
HGMOLFCO_00283 5.8e-86 M1-874 K Domain of unknown function (DUF1836)
HGMOLFCO_00284 8.3e-156 3.2.1.52 GH20 G Xylose isomerase domain protein TIM barrel
HGMOLFCO_00285 1.6e-266 pipD E Dipeptidase
HGMOLFCO_00286 3.2e-130
HGMOLFCO_00287 2.1e-88 ybaK J Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HGMOLFCO_00288 6.4e-131 gntR K UbiC transcription regulator-associated domain protein
HGMOLFCO_00289 1.1e-149 ybjI 3.1.3.102, 3.1.3.104, 3.1.3.23 S haloacid dehalogenase-like hydrolase
HGMOLFCO_00290 0.0 xfp 4.1.2.22, 4.1.2.9 G Phosphoketolase
HGMOLFCO_00291 2.9e-22 S Enoyl-(Acyl carrier protein) reductase
HGMOLFCO_00292 1.9e-172 K Bacterial regulatory helix-turn-helix protein, lysR family
HGMOLFCO_00293 1.7e-119 cah 4.2.1.1 P Eukaryotic-type carbonic anhydrase
HGMOLFCO_00294 0.0 carB 6.3.5.5 F Carbamoyl-phosphate synthase
HGMOLFCO_00295 6.9e-206 carA 6.3.5.5 F Belongs to the CarA family
HGMOLFCO_00296 7.6e-174 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
HGMOLFCO_00297 1.2e-73 lspA 3.4.23.36 MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HGMOLFCO_00298 1.4e-69 esbA S Family of unknown function (DUF5322)
HGMOLFCO_00299 3.1e-71 rnhA 3.1.26.4 L Ribonuclease HI
HGMOLFCO_00300 8.2e-108 XK27_02070 S Nitroreductase family
HGMOLFCO_00301 4e-156 yckB ET Belongs to the bacterial solute-binding protein 3 family
HGMOLFCO_00302 1.2e-118 yecS E ABC transporter permease
HGMOLFCO_00303 7.8e-36 L Integrase core domain
HGMOLFCO_00304 5.8e-129 atpB C it plays a direct role in the translocation of protons across the membrane
HGMOLFCO_00305 1.2e-16 atpE C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HGMOLFCO_00306 3.7e-53 atpF C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HGMOLFCO_00307 7.4e-92 atpH C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HGMOLFCO_00308 2.1e-285 atpA 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HGMOLFCO_00309 6.6e-165 atpG C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HGMOLFCO_00310 4.4e-253 atpD 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HGMOLFCO_00311 4.4e-68 atpC C Produces ATP from ADP in the presence of a proton gradient across the membrane
HGMOLFCO_00312 8.1e-29 S Protein of unknown function (DUF1146)
HGMOLFCO_00313 2.7e-219 murA 2.5.1.7 M EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
HGMOLFCO_00314 7.7e-183 mbl D Cell shape determining protein MreB Mrl
HGMOLFCO_00315 7.9e-32 S Protein of unknown function (DUF2969)
HGMOLFCO_00316 2.2e-221 rodA D Belongs to the SEDS family
HGMOLFCO_00318 1.5e-180 S Protein of unknown function (DUF2785)
HGMOLFCO_00319 7.7e-216 ddl 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
HGMOLFCO_00320 2.9e-151 2.3.1.19 K Helix-turn-helix XRE-family like proteins
HGMOLFCO_00321 2.3e-81 usp6 T universal stress protein
HGMOLFCO_00323 1.3e-235 rarA L recombination factor protein RarA
HGMOLFCO_00324 1.5e-85 yueI S Protein of unknown function (DUF1694)
HGMOLFCO_00325 3.3e-76 4.4.1.5 E Glyoxalase
HGMOLFCO_00326 5.3e-133 S Membrane
HGMOLFCO_00327 4.6e-149 S Uncharacterised 5xTM membrane BCR, YitT family COG1284
HGMOLFCO_00328 4.8e-269 guaA 2.3.1.128, 6.3.5.2 F Catalyzes the synthesis of GMP from XMP
HGMOLFCO_00329 2e-114 2.7.6.5 T Region found in RelA / SpoT proteins
HGMOLFCO_00330 1.8e-79 K response regulator
HGMOLFCO_00331 1.9e-130 sptS 2.7.13.3 T Histidine kinase
HGMOLFCO_00332 2e-174 coaA 2.7.1.33 F Pantothenic acid kinase
HGMOLFCO_00333 1.1e-103 2.3.1.128 K acetyltransferase
HGMOLFCO_00334 3.4e-135 IQ Dehydrogenase reductase
HGMOLFCO_00335 0.0 ltaS 2.7.8.20 M Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
HGMOLFCO_00336 2.5e-161 EG EamA-like transporter family
HGMOLFCO_00337 0.0 helD 3.6.4.12 L DNA helicase
HGMOLFCO_00338 4.3e-118 dedA S SNARE associated Golgi protein
HGMOLFCO_00339 4e-121 pgm7 5.4.2.11, 5.4.2.12 G phosphoglycerate mutase
HGMOLFCO_00340 5e-232 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HGMOLFCO_00341 1.4e-206 menC 4.2.1.113 H Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)
HGMOLFCO_00342 1.2e-134 pnuC H nicotinamide mononucleotide transporter
HGMOLFCO_00343 3.5e-299 ybeC E amino acid
HGMOLFCO_00344 1e-142 aroA 1.3.1.12, 1.3.1.43, 2.5.1.19 E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
HGMOLFCO_00345 2e-197 tyrA 1.3.1.12, 1.3.1.43 E prephenate dehydrogenase
HGMOLFCO_00346 2.5e-89 aroK 1.1.1.25, 2.7.1.71, 4.2.1.10, 4.2.3.4 F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HGMOLFCO_00347 9.3e-217 aspB E DegT/DnrJ/EryC1/StrS aminotransferase family
HGMOLFCO_00348 2.5e-183 1.1.1.28 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HGMOLFCO_00349 1.6e-177 hepT 2.5.1.30, 2.5.1.90 H Belongs to the FPP GGPP synthase family
HGMOLFCO_00350 2.4e-156 menA 2.5.1.74 H 1,4-dihydroxy-2-naphthoate
HGMOLFCO_00351 6.7e-23 S Virus attachment protein p12 family
HGMOLFCO_00352 0.0 feoB P transporter of a GTP-driven Fe(2 ) uptake system
HGMOLFCO_00353 1.4e-33 feoA P FeoA domain
HGMOLFCO_00354 8.5e-145 sufC O FeS assembly ATPase SufC
HGMOLFCO_00355 4.5e-244 sufD O FeS assembly protein SufD
HGMOLFCO_00356 1.8e-234 sufS 2.8.1.7, 4.4.1.16 E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HGMOLFCO_00357 3.2e-83 nifU C SUF system FeS assembly protein, NifU family
HGMOLFCO_00358 4.2e-272 sufB O assembly protein SufB
HGMOLFCO_00359 6.1e-183 fecB P Periplasmic binding protein
HGMOLFCO_00360 1.2e-52 yaaQ S Cyclic-di-AMP receptor
HGMOLFCO_00361 6e-117 tmk 2.7.4.9 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HGMOLFCO_00362 2.4e-21 S Protein of unknown function (DUF2508)
HGMOLFCO_00363 1.1e-109 recR L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HGMOLFCO_00364 4.9e-40 yaaK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HGMOLFCO_00365 0.0 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HGMOLFCO_00367 6.3e-80 tadA 3.5.4.33 F Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
HGMOLFCO_00368 2e-35 nrdH O Glutaredoxin
HGMOLFCO_00369 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HGMOLFCO_00370 1.9e-194 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HGMOLFCO_00371 6e-247 brnQ U Component of the transport system for branched-chain amino acids
HGMOLFCO_00372 0.0 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
HGMOLFCO_00373 0.0 cydD CO ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HGMOLFCO_00374 0.0 cydD CO ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydD
HGMOLFCO_00375 1.5e-175 cydB 1.10.3.14 C Cytochrome d ubiquinol oxidase subunit II
HGMOLFCO_00376 1.1e-272 cydA 1.10.3.14 C ubiquinol oxidase
HGMOLFCO_00377 4.6e-53 rplL J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
HGMOLFCO_00378 8.4e-82 rplJ J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HGMOLFCO_00379 4.6e-244 steT E amino acid
HGMOLFCO_00380 2.2e-120 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
HGMOLFCO_00381 2.2e-51 rplK J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HGMOLFCO_00382 5.9e-97 nusG K Participates in transcription elongation, termination and antitermination
HGMOLFCO_00383 2.4e-23 secE U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
HGMOLFCO_00384 7e-21 rpmG J Belongs to the bacterial ribosomal protein bL33 family
HGMOLFCO_00385 1.1e-104 sigH K Belongs to the sigma-70 factor family
HGMOLFCO_00386 2.6e-135 rlmB 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HGMOLFCO_00387 9.4e-71 mrnC J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HGMOLFCO_00388 6.5e-273 cysS 6.1.1.16, 6.3.1.13 J Belongs to the class-I aminoacyl-tRNA synthetase family
HGMOLFCO_00389 3.8e-99 ywlG S Belongs to the UPF0340 family
HGMOLFCO_00390 9.6e-291 gltX 6.1.1.17, 6.1.1.24 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HGMOLFCO_00391 1.4e-204 yacL S domain protein
HGMOLFCO_00392 5.6e-253 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HGMOLFCO_00393 1.4e-98 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F dUTP diphosphatase
HGMOLFCO_00394 4.2e-55 HA62_12640 S GCN5-related N-acetyl-transferase
HGMOLFCO_00395 4.3e-104 rpiA 2.7.1.12, 5.3.1.6 G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HGMOLFCO_00396 1.1e-94 maa 2.3.1.18, 2.3.1.79 S Transferase hexapeptide repeat
HGMOLFCO_00397 4e-264 pepC 3.4.22.40 E Peptidase C1-like family
HGMOLFCO_00398 3e-167 I alpha/beta hydrolase fold
HGMOLFCO_00399 5.2e-127 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HGMOLFCO_00400 2.3e-168 mleP2 S Sodium Bile acid symporter family
HGMOLFCO_00401 1.8e-189 lacM 3.2.1.23, 3.2.1.35, 3.2.1.51, 3.2.1.97 GH101,GH29 G beta-galactosidase
HGMOLFCO_00402 0.0 lacL 3.2.1.23 G Belongs to the glycosyl hydrolase 2 family
HGMOLFCO_00404 1.1e-83 ydcK S Belongs to the SprT family
HGMOLFCO_00405 0.0 yhgF K Tex-like protein N-terminal domain protein
HGMOLFCO_00406 8.8e-153 nadE 6.3.1.5 F Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
HGMOLFCO_00407 1.1e-283 pncB 6.3.4.21 F Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HGMOLFCO_00408 1.4e-127 gntR1 K UbiC transcription regulator-associated domain protein
HGMOLFCO_00409 4.3e-132 racD 5.1.1.13 M Belongs to the aspartate glutamate racemases family
HGMOLFCO_00410 3.3e-115
HGMOLFCO_00413 4.6e-165 yjjH S Calcineurin-like phosphoesterase
HGMOLFCO_00414 1.9e-254 dtpT U amino acid peptide transporter
HGMOLFCO_00415 1.3e-163 D nuclear chromosome segregation
HGMOLFCO_00416 9.7e-274 rsmF 2.1.1.176, 2.1.1.178 J NOL1 NOP2 sun family protein
HGMOLFCO_00417 1.3e-153 yitU 3.1.3.104 S hydrolase
HGMOLFCO_00418 1.4e-167 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
HGMOLFCO_00419 0.0 carB 6.3.5.5 F Carbamoyl-phosphate synthase
HGMOLFCO_00420 5.6e-208 carA 6.3.5.5 F Carbamoyl-phosphate synthetase glutamine chain
HGMOLFCO_00421 1.5e-244 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
HGMOLFCO_00422 3.4e-180 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
HGMOLFCO_00423 1.3e-56 ycsI S Protein of unknown function (DUF1445)
HGMOLFCO_00425 0.0 norZ 1.7.2.5 P Cytochrome C and Quinol oxidase polypeptide I
HGMOLFCO_00426 4e-102 norZ 1.7.2.5 P Cytochrome C and Quinol oxidase polypeptide I
HGMOLFCO_00427 1.2e-290 lysS 6.1.1.6 J Belongs to the class-II aminoacyl-tRNA synthetase family
HGMOLFCO_00428 1.9e-189 dus J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HGMOLFCO_00429 2.6e-163 hslO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HGMOLFCO_00430 0.0 ftsH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HGMOLFCO_00431 4.1e-98 hpt 2.4.2.8 F Belongs to the purine pyrimidine phosphoribosyltransferase family
HGMOLFCO_00432 2.8e-257 tilS 2.4.2.8, 6.3.4.19 J Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
HGMOLFCO_00433 3e-87 yabR J RNA binding
HGMOLFCO_00434 1.5e-56 divIC D Septum formation initiator
HGMOLFCO_00435 4.8e-39 yabO J S4 domain protein
HGMOLFCO_00436 0.0 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HGMOLFCO_00437 9.6e-103 pth 3.1.1.29 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
HGMOLFCO_00438 8.1e-114 S (CBS) domain
HGMOLFCO_00439 8.6e-57 L Toxic component of a toxin-antitoxin (TA) module
HGMOLFCO_00440 9.6e-211 alr 5.1.1.1 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HGMOLFCO_00441 2.9e-60 acpS 2.7.6.3, 2.7.8.7, 5.1.1.1 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
HGMOLFCO_00442 1.9e-254 cshA 3.6.4.13 F DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
HGMOLFCO_00443 2.1e-260 murF 6.3.2.10, 6.3.2.13 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
HGMOLFCO_00444 2.9e-157 htpX O Belongs to the peptidase M48B family
HGMOLFCO_00445 2.5e-87 lemA S LemA family
HGMOLFCO_00446 4.8e-47 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HGMOLFCO_00447 4.7e-123 srtA 3.4.22.70 M sortase family
HGMOLFCO_00448 4.6e-117 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
HGMOLFCO_00449 9.2e-231 cinA 3.5.1.42 S Belongs to the CinA family
HGMOLFCO_00450 8.5e-102 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HGMOLFCO_00451 1.8e-96 ymfM S Helix-turn-helix domain
HGMOLFCO_00452 1.7e-251 ymfH S Peptidase M16
HGMOLFCO_00453 3.3e-231 ymfF S Peptidase M16 inactive domain protein
HGMOLFCO_00454 2.4e-161 aatB ET ABC transporter substrate-binding protein
HGMOLFCO_00455 2.2e-114 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
HGMOLFCO_00456 1.4e-108 glnP P ABC transporter permease
HGMOLFCO_00457 4.3e-92 mreD M rod shape-determining protein MreD
HGMOLFCO_00458 3.7e-146 mreC M Involved in formation and maintenance of cell shape
HGMOLFCO_00459 1.9e-181 mreB D cell shape determining protein MreB
HGMOLFCO_00460 9.4e-115 radC L DNA repair protein
HGMOLFCO_00461 4.7e-249 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
HGMOLFCO_00462 0.0 valS 6.1.1.9 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
HGMOLFCO_00463 1.6e-88 tpx 1.11.1.15 O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HGMOLFCO_00466 1.4e-204 glxK 2.7.1.165 G Belongs to the glycerate kinase type-1 family
HGMOLFCO_00467 2.9e-211 EG GntP family permease
HGMOLFCO_00468 7.2e-228 thiI 2.8.1.4 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HGMOLFCO_00469 2.9e-215 iscS2 2.8.1.7 E Aminotransferase class V
HGMOLFCO_00470 7e-306 ezrA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HGMOLFCO_00471 1.7e-108 rpsD J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HGMOLFCO_00472 7.6e-188 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HGMOLFCO_00473 2.9e-226 mtnE 2.6.1.83 E Aminotransferase
HGMOLFCO_00474 5.7e-146 mtnU 3.5.1.3 S Carbon-nitrogen hydrolase
HGMOLFCO_00475 2.1e-171 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
HGMOLFCO_00476 5.3e-184 gpsA 1.1.1.94 I Glycerol-3-phosphate dehydrogenase
HGMOLFCO_00477 9.6e-163 lgt 2.1.1.199 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HGMOLFCO_00478 3.9e-176 hprK F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HGMOLFCO_00479 1.2e-47 yvlD S Mycobacterial 4 TMS phage holin, superfamily IV
HGMOLFCO_00480 4.1e-53 KT PspC domain protein
HGMOLFCO_00481 4.5e-202 prfB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HGMOLFCO_00482 0.0 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
HGMOLFCO_00483 6.5e-96 hpf J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HGMOLFCO_00484 6.1e-128 comFC S Competence protein
HGMOLFCO_00485 2e-252 comFA L Helicase C-terminal domain protein
HGMOLFCO_00486 9e-113 yvyE 3.4.13.9 S YigZ family
HGMOLFCO_00487 6.4e-38
HGMOLFCO_00488 0.0 ydaO E amino acid
HGMOLFCO_00489 5.7e-289 groL O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
HGMOLFCO_00490 7.4e-43 groS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HGMOLFCO_00491 4.4e-115 rex K Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HGMOLFCO_00492 0.0 uup S ABC transporter, ATP-binding protein
HGMOLFCO_00493 1.4e-173 birA 6.3.4.15 H Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
HGMOLFCO_00494 9.7e-92 bioY S BioY family
HGMOLFCO_00495 1e-134 fabI 1.3.1.10, 1.3.1.9 I Enoyl- acyl-carrier-protein reductase NADH
HGMOLFCO_00496 1e-139 accA 2.1.3.15, 6.4.1.2 I alpha subunit
HGMOLFCO_00497 1.5e-160 accD 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HGMOLFCO_00498 7.1e-264 accC 6.3.4.14, 6.4.1.2 I Acetyl-CoA carboxylase biotin carboxylase subunit
HGMOLFCO_00499 1.3e-75 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
HGMOLFCO_00500 1.6e-63 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
HGMOLFCO_00501 1.7e-229 fabF 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
HGMOLFCO_00502 2.7e-129 IQ reductase
HGMOLFCO_00503 2.8e-171 fabD 2.3.1.39 I Malonyl CoA-acyl carrier protein transacylase
HGMOLFCO_00504 4.2e-34 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
HGMOLFCO_00505 4.4e-172 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HGMOLFCO_00506 1.4e-68 marR K Transcriptional regulator, MarR family
HGMOLFCO_00507 2.7e-76 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
HGMOLFCO_00509 1.2e-194 tsaD 2.3.1.234 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HGMOLFCO_00510 1.3e-110 rimI 2.3.1.128 K Ribosomal-protein-alanine acetyltransferase
HGMOLFCO_00511 8.4e-131 yeaZ 2.3.1.234 O Universal bacterial protein YeaZ
HGMOLFCO_00512 1.2e-114 pyrE 2.4.2.10, 4.1.1.23 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HGMOLFCO_00513 2.4e-130 pyrF 4.1.1.23 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
HGMOLFCO_00514 1.9e-95 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HGMOLFCO_00515 6.4e-257 gabD 1.2.1.16, 1.2.1.20, 1.2.1.79 C Belongs to the aldehyde dehydrogenase family
HGMOLFCO_00516 3e-248 purA 6.3.4.4 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HGMOLFCO_00517 7.4e-167 guaC 1.1.1.205, 1.7.1.7 F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
HGMOLFCO_00518 2.4e-93 K transcriptional regulator
HGMOLFCO_00519 6.6e-128 ybhF_2 V AAA domain, putative AbiEii toxin, Type IV TA system
HGMOLFCO_00520 6e-189 ybhR V ABC transporter
HGMOLFCO_00521 1.7e-65 arsC 1.20.4.1 P Belongs to the ArsC family
HGMOLFCO_00522 2.2e-288 glpQ 3.1.4.46 C phosphodiesterase
HGMOLFCO_00523 6.8e-164 yvgN C Aldo keto reductase
HGMOLFCO_00524 0.0 addA 3.6.4.12 L ATP-dependent helicase nuclease subunit A
HGMOLFCO_00525 0.0 rexB 3.1.21.3, 3.6.4.12 L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' - 3' nuclease activity
HGMOLFCO_00526 3.7e-279 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HGMOLFCO_00527 0.0 clpL O associated with various cellular activities
HGMOLFCO_00528 2.7e-35
HGMOLFCO_00529 1.2e-214 patA 2.6.1.1 E Aminotransferase
HGMOLFCO_00530 1.4e-183 D Alpha beta
HGMOLFCO_00531 1.8e-189 pacA 3.5.1.24 M Linear amide C-N hydrolase, choloylglycine hydrolase family protein
HGMOLFCO_00532 1.1e-110 ysdA CP transmembrane transport
HGMOLFCO_00533 1.4e-116 pgmB 2.4.1.64, 3.1.3.12, 3.2.1.28, 5.4.2.6 GH37,GH65 S beta-phosphoglucomutase
HGMOLFCO_00534 0.0 mapA 2.4.1.8 GH65 G hydrolase, family 65, central catalytic
HGMOLFCO_00535 7.4e-250 malT G Major Facilitator
HGMOLFCO_00536 3.7e-176 malR K Transcriptional regulator, LacI family
HGMOLFCO_00537 5.7e-71 K Transcriptional regulator
HGMOLFCO_00538 3e-81 rlmH 2.1.1.177 J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HGMOLFCO_00539 3e-208 htrA 3.4.21.107 O serine protease
HGMOLFCO_00540 6e-154 vicX 3.1.26.11 S domain protein
HGMOLFCO_00541 8e-143 yycI S YycH protein
HGMOLFCO_00542 1.1e-239 yycH S YycH protein
HGMOLFCO_00543 0.0 vicK 2.7.13.3 T Histidine kinase
HGMOLFCO_00544 6.8e-130 K response regulator
HGMOLFCO_00547 1.3e-40 rpmE2 J Ribosomal protein L31
HGMOLFCO_00548 2.3e-237 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HGMOLFCO_00549 4.4e-311 pyrG 6.3.4.2 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
HGMOLFCO_00550 1.6e-47 rpoE K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
HGMOLFCO_00551 3.2e-74 ywiB S Domain of unknown function (DUF1934)
HGMOLFCO_00552 1.5e-266 ywfO S HD domain protein
HGMOLFCO_00553 6.4e-143 yxeH S hydrolase
HGMOLFCO_00554 4.5e-206 V domain protein
HGMOLFCO_00555 1.9e-92 K Transcriptional regulator (TetR family)
HGMOLFCO_00556 3.1e-187 galM 5.1.3.3 G Catalyzes the interconversion of alpha and beta anomers of maltose
HGMOLFCO_00557 2.2e-168
HGMOLFCO_00559 4e-83 zur P Belongs to the Fur family
HGMOLFCO_00560 1.7e-105 gmk2 2.7.4.8 F Guanylate kinase
HGMOLFCO_00561 1.3e-72 apfA 2.7.7.72, 3.6.1.61 F Nudix hydrolase
HGMOLFCO_00562 2.6e-205 yfnA E Amino Acid
HGMOLFCO_00563 0.0 pepX 3.4.14.11 E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline
HGMOLFCO_00564 1.1e-243 ganB 3.2.1.89 G arabinogalactan
HGMOLFCO_00565 7.8e-64 gntR1 K Transcriptional regulator, GntR family
HGMOLFCO_00566 6.8e-156 V ABC transporter, ATP-binding protein
HGMOLFCO_00567 1.2e-14
HGMOLFCO_00568 2.8e-157 recA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HGMOLFCO_00569 1e-202 rny S Endoribonuclease that initiates mRNA decay
HGMOLFCO_00570 0.0 mutS L that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HGMOLFCO_00571 0.0 mutL L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HGMOLFCO_00572 1.1e-104 ruvA 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
HGMOLFCO_00573 1.1e-189 ruvB 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
HGMOLFCO_00574 2.9e-176 2.4.2.29 F queuine tRNA-ribosyltransferase activity
HGMOLFCO_00575 5.5e-42 yajC U Preprotein translocase
HGMOLFCO_00576 6.8e-181 nrnA 3.1.13.3, 3.1.3.7 S DHHA1 domain protein
HGMOLFCO_00577 6.4e-233 cshB 3.6.4.13 JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
HGMOLFCO_00578 0.0 alaS 6.1.1.7 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HGMOLFCO_00579 1.2e-42 yrzL S Belongs to the UPF0297 family
HGMOLFCO_00580 9.6e-74 yqgF J Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HGMOLFCO_00581 1.6e-38 yrzB S Belongs to the UPF0473 family
HGMOLFCO_00582 4.6e-163 rnhC 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HGMOLFCO_00583 4.7e-91 cvpA S Colicin V production protein
HGMOLFCO_00584 0.0 mutS2 L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
HGMOLFCO_00585 8.5e-198 ilvE 2.6.1.42 E Branched-chain amino acid aminotransferase
HGMOLFCO_00586 6.2e-171 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
HGMOLFCO_00587 2.8e-137 cof S haloacid dehalogenase-like hydrolase
HGMOLFCO_00588 0.0 pgm 5.4.2.2, 5.4.2.8 G Phosphoglucomutase phosphomannomutase, alpha beta alpha domain
HGMOLFCO_00589 1.4e-113 yfbR S HD containing hydrolase-like enzyme
HGMOLFCO_00591 0.0 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
HGMOLFCO_00592 0.0 uvrA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
HGMOLFCO_00593 9.9e-205
HGMOLFCO_00594 3.2e-161 rapZ S Displays ATPase and GTPase activities
HGMOLFCO_00595 1.7e-187 ybhK S Required for morphogenesis under gluconeogenic growth conditions
HGMOLFCO_00596 4.2e-167 whiA K May be required for sporulation
HGMOLFCO_00597 1.5e-120 tenA 3.5.99.2 K Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HGMOLFCO_00598 1.3e-102 clpP 3.4.21.92 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
HGMOLFCO_00602 2.6e-91 pstS P Phosphate
HGMOLFCO_00603 1.2e-97 pstC P probably responsible for the translocation of the substrate across the membrane
HGMOLFCO_00604 1.3e-103 pstA P Phosphate transport system permease protein PstA
HGMOLFCO_00605 2.8e-95 pstB 3.6.3.27 L Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
HGMOLFCO_00606 1.5e-205 fni 1.1.1.88, 5.3.3.2 C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
HGMOLFCO_00607 1.5e-211 mvaK2 2.7.1.36, 2.7.1.43, 2.7.4.2 I phosphomevalonate kinase
HGMOLFCO_00608 8.2e-182 mvaD 4.1.1.33 I diphosphomevalonate decarboxylase
HGMOLFCO_00609 5.4e-167 mvk 1.1.1.88, 2.3.3.10, 2.7.1.36 I mevalonate kinase
HGMOLFCO_00610 0.0 dinG 2.7.7.7, 3.6.4.12 L helicase involved in DNA repair and perhaps also replication
HGMOLFCO_00611 1.6e-88 ypmB S Protein conserved in bacteria
HGMOLFCO_00612 2.1e-257 asnS 6.1.1.22 J Asparaginyl-tRNA synthetase
HGMOLFCO_00613 4.7e-134 dnaD L DnaD domain protein
HGMOLFCO_00614 1.3e-121 ypuA S Protein of unknown function (DUF1002)
HGMOLFCO_00615 3.7e-193 C Aldo keto reductase family protein
HGMOLFCO_00616 3.1e-159 EG EamA-like transporter family
HGMOLFCO_00617 0.0 ponA 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein 1A
HGMOLFCO_00618 3.9e-116 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
HGMOLFCO_00619 1.7e-110 ypsA S Belongs to the UPF0398 family
HGMOLFCO_00620 4.6e-58 gpsB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
HGMOLFCO_00621 0.0 tetP J elongation factor G
HGMOLFCO_00622 4e-212 S Type IV secretion-system coupling protein DNA-binding domain
HGMOLFCO_00623 8.9e-83 F Hydrolase, NUDIX family
HGMOLFCO_00624 8.5e-215 rlmL 2.1.1.173, 2.1.1.264 L Belongs to the methyltransferase superfamily
HGMOLFCO_00625 1.3e-88 arcD S C4-dicarboxylate anaerobic carrier
HGMOLFCO_00626 5.9e-28 arcD S C4-dicarboxylate anaerobic carrier
HGMOLFCO_00627 1.2e-272 nylA 3.5.1.4 J Belongs to the amidase family
HGMOLFCO_00629 3.9e-276 lacS G Transporter
HGMOLFCO_00630 0.0 rafA 3.2.1.22 G alpha-galactosidase
HGMOLFCO_00631 1.6e-180 galR K Transcriptional regulator
HGMOLFCO_00632 8.1e-287 galT 2.7.7.12 G UDP-glucose--hexose-1-phosphate uridylyltransferase
HGMOLFCO_00633 1e-223 galK 2.7.1.6 F Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HGMOLFCO_00634 7.7e-185 celE 3.2.1.4 GH5,GH9 E GDSL-like Lipase/Acylhydrolase family
HGMOLFCO_00635 1.6e-143 ptp3 3.1.3.48 T Tyrosine phosphatase family
HGMOLFCO_00636 2.7e-96 yxkA S Phosphatidylethanolamine-binding protein
HGMOLFCO_00637 2e-35
HGMOLFCO_00638 6.6e-136 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
HGMOLFCO_00639 5.3e-119 tcyB U Binding-protein-dependent transport system inner membrane component
HGMOLFCO_00640 1.7e-140 tcyA ET Belongs to the bacterial solute-binding protein 3 family
HGMOLFCO_00641 2e-52
HGMOLFCO_00642 9e-170 MA20_03535 1.1.1.399, 1.1.1.95 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HGMOLFCO_00643 1.7e-79 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
HGMOLFCO_00644 6.9e-147 pnuC H nicotinamide mononucleotide transporter
HGMOLFCO_00645 1.1e-92 ymdB S Macro domain protein
HGMOLFCO_00646 0.0 pepO 3.4.24.71 O Peptidase family M13
HGMOLFCO_00647 1.8e-229 pbuG S permease
HGMOLFCO_00648 2.1e-45
HGMOLFCO_00649 1.4e-212 S Putative metallopeptidase domain
HGMOLFCO_00650 2.6e-203 3.1.3.1 S associated with various cellular activities
HGMOLFCO_00651 6.5e-116 mpg 3.2.2.21 L Belongs to the DNA glycosylase MPG family
HGMOLFCO_00652 6.8e-65 yeaO S Protein of unknown function, DUF488
HGMOLFCO_00654 4.8e-125 yrkL S Flavodoxin-like fold
HGMOLFCO_00655 5.6e-55
HGMOLFCO_00656 2.2e-108 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX
HGMOLFCO_00657 1e-96 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HGMOLFCO_00658 2.4e-102
HGMOLFCO_00659 9.5e-26
HGMOLFCO_00660 2.6e-127 scrR K Transcriptional regulator, LacI family
HGMOLFCO_00661 5.5e-172 acm2 3.2.1.17 NU Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
HGMOLFCO_00662 2.6e-46 czrA K Transcriptional regulator, ArsR family
HGMOLFCO_00663 1.9e-103
HGMOLFCO_00664 1.3e-213 aroC 4.2.3.5 E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HGMOLFCO_00665 7.6e-13 pheA 1.3.1.12, 2.3.1.79, 4.2.1.51, 5.4.99.5 E Chorismate mutase type II
HGMOLFCO_00666 1.2e-211 ydiN G Major Facilitator Superfamily
HGMOLFCO_00668 6.9e-249 dtpT U amino acid peptide transporter
HGMOLFCO_00671 1.5e-152 S Sucrose-6F-phosphate phosphohydrolase
HGMOLFCO_00672 2.4e-44 1.6.5.2 GM NAD(P)H-binding
HGMOLFCO_00673 1e-90 1.6.5.2 GM NAD(P)H-binding
HGMOLFCO_00674 2.6e-42 S Alpha beta hydrolase
HGMOLFCO_00675 1.5e-36 S Alpha beta hydrolase
HGMOLFCO_00676 1.2e-34 S Alpha beta hydrolase
HGMOLFCO_00677 1.5e-235 lmrB EGP Major facilitator Superfamily
HGMOLFCO_00679 0.0 S Bacterial membrane protein YfhO
HGMOLFCO_00680 3.6e-41
HGMOLFCO_00681 1e-120 mleP3 S Membrane transport protein
HGMOLFCO_00682 1.1e-52 trxA O Belongs to the thioredoxin family
HGMOLFCO_00683 1.7e-254 gor 1.8.1.7 C pyridine nucleotide-disulfide oxidoreductase
HGMOLFCO_00684 1.6e-208 EGP Major facilitator Superfamily
HGMOLFCO_00685 4.6e-211 ycsG P Natural resistance-associated macrophage protein
HGMOLFCO_00686 1e-136 ycsF S LamB/YcsF family
HGMOLFCO_00687 7.6e-258 accC 6.3.4.14, 6.4.1.2 I Acetyl-CoA carboxylase biotin carboxylase subunit
HGMOLFCO_00688 3.2e-58 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
HGMOLFCO_00689 1.4e-189 kipA 6.3.4.6 E Allophanate hydrolase subunit 2
HGMOLFCO_00690 7.9e-134 ybgJ 3.5.1.54 E Allophanate hydrolase subunit 1
HGMOLFCO_00691 8.7e-72 K helix_turn_helix, mercury resistance
HGMOLFCO_00692 5.9e-82 S Psort location Cytoplasmic, score
HGMOLFCO_00693 1e-287 dinB 2.7.7.7 L impB/mucB/samB family C-terminal domain
HGMOLFCO_00694 1.1e-95 wecD K Acetyltransferase (GNAT) family
HGMOLFCO_00695 4.2e-104 3.2.1.17 NU mannosyl-glycoprotein
HGMOLFCO_00696 9.1e-121 asnA 6.3.1.1 F aspartate--ammonia ligase
HGMOLFCO_00697 1.9e-08 yjjG 3.1.3.102, 3.1.3.104, 3.1.3.5, 3.8.1.2 E hydrolase
HGMOLFCO_00698 4.5e-208 guaB 1.1.1.205 F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
HGMOLFCO_00699 5.9e-135 XK27_01040 S Protein of unknown function (DUF1129)
HGMOLFCO_00700 4.4e-200 ychF J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
HGMOLFCO_00701 7.9e-31 yyzM S Bacterial protein of unknown function (DUF951)
HGMOLFCO_00702 3.3e-147 spo0J K Belongs to the ParB family
HGMOLFCO_00703 1.1e-156 noc K Belongs to the ParB family
HGMOLFCO_00704 9e-133 rsmG 2.1.1.170 J Specifically methylates the N7 position of a guanine in 16S rRNA
HGMOLFCO_00705 2.2e-144 rihC 3.2.2.1 F Nucleoside
HGMOLFCO_00706 1.9e-212 nupG F Nucleoside transporter
HGMOLFCO_00707 1.4e-251 cycA E Amino acid permease
HGMOLFCO_00708 2.2e-134 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
HGMOLFCO_00709 1.2e-226 glnP P ABC transporter
HGMOLFCO_00711 1e-187 trpS 6.1.1.2 J Belongs to the class-I aminoacyl-tRNA synthetase family
HGMOLFCO_00713 1.2e-228 serS 6.1.1.11 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HGMOLFCO_00714 0.0 sbcC L Putative exonuclease SbcCD, C subunit
HGMOLFCO_00715 1.5e-219 sbcD L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
HGMOLFCO_00717 8.3e-298 dltA 6.1.1.13 H Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HGMOLFCO_00718 7e-239 dltB M MBOAT, membrane-bound O-acyltransferase family
HGMOLFCO_00719 1.2e-35 dltC 6.1.1.13 J Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HGMOLFCO_00720 7.1e-242 dltD M Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HGMOLFCO_00721 3.1e-122 iolS C Aldo keto reductase
HGMOLFCO_00722 7.3e-14 brnQ U Component of the transport system for branched-chain amino acids
HGMOLFCO_00723 6.8e-87 brnQ U Component of the transport system for branched-chain amino acids
HGMOLFCO_00724 9.9e-245 rumA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HGMOLFCO_00725 2.2e-218 argE 3.5.1.18 E succinyl-diaminopimelate desuccinylase
HGMOLFCO_00726 5.8e-97 metI P ABC transporter permease
HGMOLFCO_00727 1.6e-191 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HGMOLFCO_00728 2.7e-149 metQ1 P Belongs to the nlpA lipoprotein family
HGMOLFCO_00729 1.6e-261 tagE2 2.4.1.52 GT4 M Poly(Glycerol-phosphate) alpha-glucosyltransferase
HGMOLFCO_00730 3.2e-273 tagE3 2.4.1.52 GT4 M Glycosyl transferases group 1
HGMOLFCO_00731 6.9e-47
HGMOLFCO_00732 7.9e-11 gntT EG gluconate transmembrane transporter activity
HGMOLFCO_00733 0.0 kup P Transport of potassium into the cell
HGMOLFCO_00735 3.9e-284 glpK 2.7.1.30 F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HGMOLFCO_00736 5.4e-26 dmpI 5.3.2.6 G Belongs to the 4-oxalocrotonate tautomerase family
HGMOLFCO_00737 0.0 yjbQ P TrkA C-terminal domain protein
HGMOLFCO_00738 1.4e-275 pipD E Dipeptidase
HGMOLFCO_00739 3.4e-158 S Alpha/beta hydrolase of unknown function (DUF915)
HGMOLFCO_00740 8.8e-240 pts13C G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HGMOLFCO_00741 5.4e-43 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HGMOLFCO_00742 1.6e-168 T Calcineurin-like phosphoesterase superfamily domain
HGMOLFCO_00743 9.5e-160 EGP Major facilitator Superfamily
HGMOLFCO_00744 3.4e-201 mdtG EGP Major facilitator Superfamily
HGMOLFCO_00745 5.3e-251 yhdP S Transporter associated domain
HGMOLFCO_00746 3.3e-73 K LysR substrate binding domain protein
HGMOLFCO_00747 4.4e-14 K LysR substrate binding domain protein
HGMOLFCO_00748 3.4e-216 E GDSL-like Lipase/Acylhydrolase family
HGMOLFCO_00749 2.3e-195 lplA 6.3.1.20 H Lipoate-protein ligase
HGMOLFCO_00750 6.9e-259 lpdA 1.8.1.4 C Dehydrogenase
HGMOLFCO_00751 1.5e-204 pdhC 2.3.1.12 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
HGMOLFCO_00752 5.8e-180 pdhB 1.2.4.1 C Transketolase, C-terminal domain protein
HGMOLFCO_00753 4.8e-183 pdhA 1.2.4.1, 1.2.4.4 C Dehydrogenase E1 component
HGMOLFCO_00754 2.4e-160 brpA K Cell envelope-like function transcriptional attenuator common domain protein
HGMOLFCO_00755 4.5e-127 epsB M biosynthesis protein
HGMOLFCO_00756 1.4e-112 ywqD 2.7.10.1 D Capsular exopolysaccharide family
HGMOLFCO_00757 5.1e-139 ywqE 3.1.3.48 GM PHP domain protein
HGMOLFCO_00758 4e-89 capM M Bacterial sugar transferase
HGMOLFCO_00759 3.6e-69 M Glycosyl transferase 4-like
HGMOLFCO_00761 9.2e-86 L PFAM Integrase catalytic region
HGMOLFCO_00762 3.4e-147 ubiB S ABC1 family
HGMOLFCO_00763 1e-130 1.14.12.17 C Oxidoreductase NAD-binding domain
HGMOLFCO_00764 2.3e-170 GK ROK family
HGMOLFCO_00765 3.9e-41
HGMOLFCO_00766 4.2e-80 copY K Copper transport repressor CopY TcrY
HGMOLFCO_00768 1.6e-76 3.6.3.6 P ATPase, P-type transporting, HAD superfamily, subfamily IC
HGMOLFCO_00769 4.1e-12 traP 1.14.99.57, 6.2.1.3 S enzyme involved in biosynthesis of extracellular polysaccharides
HGMOLFCO_00770 5.3e-170 mutR K Transcriptional activator, Rgg GadR MutR family
HGMOLFCO_00771 2e-288 gntK 2.7.1.12, 2.7.1.17 G Belongs to the FGGY kinase family
HGMOLFCO_00772 3.2e-229 gntT EG Gluconate
HGMOLFCO_00773 3.2e-181 K Transcriptional regulator, LacI family
HGMOLFCO_00774 4.3e-61 yneR
HGMOLFCO_00775 9.2e-220 aspB 2.6.1.1, 2.6.1.14 E Aminotransferase
HGMOLFCO_00776 2.2e-96 V VanZ like family
HGMOLFCO_00777 7.3e-10 gshF 6.3.2.2 H Belongs to the glutamate--cysteine ligase type 1 family
HGMOLFCO_00778 1.9e-77 XK27_08315 M Sulfatase
HGMOLFCO_00779 3.8e-167 map 3.4.11.18 E Methionine Aminopeptidase
HGMOLFCO_00780 8.5e-78 fld C Flavodoxin
HGMOLFCO_00781 3e-75 gtcA S Teichoic acid glycosylation protein
HGMOLFCO_00783 2.6e-231 yfmL 3.6.4.13 L DEAD DEAH box helicase
HGMOLFCO_00784 1.3e-190 mocA S Oxidoreductase
HGMOLFCO_00785 4.9e-63 S Domain of unknown function (DUF4828)
HGMOLFCO_00786 2e-103 yvdD 3.2.2.10 S Belongs to the LOG family
HGMOLFCO_00787 2.5e-161 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
HGMOLFCO_00788 5e-287 gshF 6.3.2.2 H Belongs to the glutamate--cysteine ligase type 1 family
HGMOLFCO_00789 8.9e-139 S NADPH-dependent FMN reductase
HGMOLFCO_00790 3.9e-33 yneR S Belongs to the HesB IscA family
HGMOLFCO_00791 1.3e-304 ybiT S ABC transporter, ATP-binding protein
HGMOLFCO_00792 6.4e-84 dps P Belongs to the Dps family
HGMOLFCO_00793 1.6e-105
HGMOLFCO_00794 4.3e-183 brpA K Cell envelope-like function transcriptional attenuator common domain protein
HGMOLFCO_00795 1.4e-101 K helix_turn_helix multiple antibiotic resistance protein
HGMOLFCO_00796 6.6e-64 fsr EGP Major Facilitator Superfamily
HGMOLFCO_00797 2.8e-47 fsr EGP Major Facilitator Superfamily
HGMOLFCO_00798 2.1e-99 ogt 2.1.1.63, 3.2.2.20 L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HGMOLFCO_00799 1.7e-102 S CAAX protease self-immunity
HGMOLFCO_00801 4.1e-119 Q Methyltransferase domain
HGMOLFCO_00802 1.2e-60 1.5.1.40 S NADP oxidoreductase coenzyme F420-dependent
HGMOLFCO_00803 5.6e-20 1.5.1.40 S NADP oxidoreductase coenzyme F420-dependent
HGMOLFCO_00804 1.4e-50 K 2 iron, 2 sulfur cluster binding
HGMOLFCO_00805 0.0 mco Q Multicopper oxidase
HGMOLFCO_00806 7.1e-89 S Aminoacyl-tRNA editing domain
HGMOLFCO_00807 3.1e-75 ddaH 3.5.3.18 E Amidinotransferase
HGMOLFCO_00809 1e-193 nhaC C Na H antiporter NhaC
HGMOLFCO_00810 2.1e-143 S Oxidoreductase family, NAD-binding Rossmann fold
HGMOLFCO_00812 9.7e-179 S Phosphotransferase system, EIIC
HGMOLFCO_00813 4.6e-23 D mRNA cleavage
HGMOLFCO_00814 1.9e-21 2.3.1.15 D Antitoxin component of a toxin-antitoxin (TA) module
HGMOLFCO_00815 3.6e-48 rpsF J Binds together with S18 to 16S ribosomal RNA
HGMOLFCO_00816 6.4e-91 ssb L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
HGMOLFCO_00817 2.1e-35 rpsR J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HGMOLFCO_00818 0.0 yybT T signaling protein consisting of a modified GGDEF domain and a DHH domain
HGMOLFCO_00819 1.2e-74 rplI J Binds to the 23S rRNA
HGMOLFCO_00820 1.8e-243 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
HGMOLFCO_00821 6.7e-207 lmrP E Major Facilitator Superfamily
HGMOLFCO_00822 1.2e-48
HGMOLFCO_00823 1.2e-166 znuA P Belongs to the bacterial solute-binding protein 9 family
HGMOLFCO_00824 5.4e-95 fhuC P ABC transporter
HGMOLFCO_00825 4.2e-128 znuB U ABC 3 transport family
HGMOLFCO_00826 7.5e-152 purR 2.4.2.22, 2.4.2.7 F pur operon repressor
HGMOLFCO_00827 7.3e-205 glmU 2.3.1.157, 2.7.7.23 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HGMOLFCO_00828 1.4e-176 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HGMOLFCO_00829 3e-32
HGMOLFCO_00831 1.6e-85 K GNAT family
HGMOLFCO_00832 5.2e-122 XK27_08875 O PFAM peptidase M10A and M12B, matrixin and adamalysin
HGMOLFCO_00833 4e-161 ytbE 1.1.1.346 S Aldo keto reductase
HGMOLFCO_00834 6.3e-145 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
HGMOLFCO_00835 3.7e-131 budA 4.1.1.5 H Belongs to the alpha-acetolactate decarboxylase family
HGMOLFCO_00837 1e-56
HGMOLFCO_00840 1.8e-78 K Winged helix DNA-binding domain
HGMOLFCO_00841 0.0 lmrA V ABC transporter, ATP-binding protein
HGMOLFCO_00842 0.0 yfiC V ABC transporter
HGMOLFCO_00843 2.8e-193 ampC V Beta-lactamase
HGMOLFCO_00844 6.4e-287 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HGMOLFCO_00845 2.8e-48
HGMOLFCO_00846 3.4e-140 cobQ S CobB/CobQ-like glutamine amidotransferase domain
HGMOLFCO_00847 7.5e-263 murF 6.3.2.10, 6.3.2.13 M Domain of unknown function (DUF1727)
HGMOLFCO_00848 3.2e-109 tdk 2.7.1.21 F thymidine kinase
HGMOLFCO_00849 4.2e-155 prfA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HGMOLFCO_00850 1.6e-157 prmB 2.1.1.297, 2.1.1.298 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
HGMOLFCO_00851 2.3e-195 ywlC 2.7.7.87, 3.1.3.48 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
HGMOLFCO_00852 4.6e-230 glyA 2.1.2.1 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HGMOLFCO_00853 1.2e-114 upp 2.4.2.9 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HGMOLFCO_00854 2.9e-183 yibE S overlaps another CDS with the same product name
HGMOLFCO_00855 1.5e-125 yibF S overlaps another CDS with the same product name
HGMOLFCO_00856 5.4e-218 pyrP F Permease
HGMOLFCO_00860 1.1e-09 C Aldo keto reductase
HGMOLFCO_00861 7.3e-25 C Aldo keto reductase
HGMOLFCO_00862 2.1e-07 K Bacterial regulatory helix-turn-helix protein, lysR family
HGMOLFCO_00864 1.5e-45 S Alpha/beta hydrolase family
HGMOLFCO_00865 6.4e-44 S Alpha/beta hydrolase family
HGMOLFCO_00866 3e-119 pnb C nitroreductase
HGMOLFCO_00867 1.2e-32 flpA 4.1.99.16, 4.2.3.22, 4.2.3.75 K helix_turn_helix, cAMP Regulatory protein
HGMOLFCO_00868 2.4e-44 S Tautomerase enzyme
HGMOLFCO_00869 3.6e-29 S Domain of unknown function (DUF4767)
HGMOLFCO_00870 3.1e-178 3.4.11.5 E Releases the N-terminal proline from various substrates
HGMOLFCO_00871 6.6e-116 gph 3.1.3.18 S HAD hydrolase, family IA, variant
HGMOLFCO_00872 1e-272 S Uncharacterized protein conserved in bacteria (DUF2325)
HGMOLFCO_00873 1.2e-182 1.17.4.1 F Ribonucleotide reductase, small chain
HGMOLFCO_00874 4.4e-169 nrdF 1.17.4.1 F Ribonucleotide reductase, small chain
HGMOLFCO_00875 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HGMOLFCO_00876 1.4e-83 nrdI F NrdI Flavodoxin like
HGMOLFCO_00877 5.1e-110 M ErfK YbiS YcfS YnhG
HGMOLFCO_00879 1.3e-204 nrnB S DHHA1 domain
HGMOLFCO_00880 3.4e-291 S ABC transporter, ATP-binding protein
HGMOLFCO_00881 1.7e-179 ABC-SBP S ABC transporter
HGMOLFCO_00882 1e-138 XK27_08840 U Belongs to the binding-protein-dependent transport system permease family
HGMOLFCO_00883 1.4e-133 XK27_08845 S ABC transporter, ATP-binding protein
HGMOLFCO_00885 3.3e-225 amtB P ammonium transporter
HGMOLFCO_00886 4.3e-234 mepA V MATE efflux family protein
HGMOLFCO_00887 2.9e-170 scrK 2.7.1.2, 2.7.1.4 GK ROK family
HGMOLFCO_00888 5.2e-170 cysK 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
HGMOLFCO_00889 1.3e-153 metAA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to
HGMOLFCO_00890 1.7e-131 trxB 1.8.1.9 C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
HGMOLFCO_00891 1.5e-76 yphH S Cupin domain
HGMOLFCO_00892 1.8e-75 argR K Regulates arginine biosynthesis genes
HGMOLFCO_00893 5.5e-124 devA 3.6.3.25 V ABC transporter, ATP-binding protein
HGMOLFCO_00894 8.6e-158 hrtB V ABC transporter permease
HGMOLFCO_00895 1.1e-107 ygfC K Bacterial regulatory proteins, tetR family
HGMOLFCO_00896 2.4e-189 tdh 1.1.1.14 E Alcohol dehydrogenase GroES-like domain
HGMOLFCO_00897 1.4e-281 mntH P H( )-stimulated, divalent metal cation uptake system
HGMOLFCO_00898 2.2e-22
HGMOLFCO_00899 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HGMOLFCO_00900 1.2e-69 L nuclease
HGMOLFCO_00901 8.4e-162 F DNA/RNA non-specific endonuclease
HGMOLFCO_00902 6.6e-113 lepB 3.4.21.89 U Belongs to the peptidase S26 family
HGMOLFCO_00903 1.4e-292 murE 6.3.2.13, 6.3.2.7 M Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HGMOLFCO_00904 4.4e-291 murE 6.3.2.13, 6.3.2.7 M Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HGMOLFCO_00905 0.0 asnB 6.3.5.4 E Asparagine synthase
HGMOLFCO_00906 6.6e-220 lysP E amino acid
HGMOLFCO_00907 7e-49 mscL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
HGMOLFCO_00908 0.0 gidA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
HGMOLFCO_00909 1.1e-253 mnmE S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HGMOLFCO_00910 1.2e-152 jag S R3H domain protein
HGMOLFCO_00911 3.4e-144 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HGMOLFCO_00912 1.4e-56 rnpA 3.1.26.5 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
HGMOLFCO_00913 2.6e-14 rpmH J Belongs to the bacterial ribosomal protein bL34 family
HGMOLFCO_00914 1.4e-248 dnaA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HGMOLFCO_00915 3.8e-207 dnaN 2.7.7.7 L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
HGMOLFCO_00916 2.2e-34 yaaA S S4 domain protein YaaA
HGMOLFCO_00917 1.5e-203 recF L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HGMOLFCO_00918 0.0 gyrB 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HGMOLFCO_00919 0.0 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HGMOLFCO_00920 2.9e-159 ispE 2.1.1.182, 2.7.1.148 F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HGMOLFCO_00921 1.2e-160 ksgA 2.1.1.182 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
HGMOLFCO_00922 5.6e-98 rnmV 3.1.26.8 J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HGMOLFCO_00923 1.8e-147 tatD L hydrolase, TatD family
HGMOLFCO_00924 0.0 metG 6.1.1.10 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HGMOLFCO_00925 9.5e-163 yunF F Protein of unknown function DUF72
HGMOLFCO_00926 5.3e-212 norA EGP Major facilitator Superfamily
HGMOLFCO_00927 4.4e-129 cobB K SIR2 family
HGMOLFCO_00928 2.2e-187
HGMOLFCO_00929 6.8e-221 mvaA 1.1.1.34, 1.1.1.88, 2.3.1.9 C Belongs to the HMG-CoA reductase family
HGMOLFCO_00930 6.6e-173 ppx 3.6.1.11, 3.6.1.40 FP exopolyphosphatase
HGMOLFCO_00931 0.0 helD 3.6.4.12 L DNA helicase
HGMOLFCO_00932 1.2e-203 napA P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
HGMOLFCO_00933 3.7e-154 metQ_4 P Belongs to the nlpA lipoprotein family
HGMOLFCO_00935 6e-140 nfrA 1.5.1.38, 1.5.1.39 C nitroreductase
HGMOLFCO_00936 3e-24 phaG GT1 I carboxylic ester hydrolase activity
HGMOLFCO_00937 1.8e-51 K Transcriptional regulator
HGMOLFCO_00938 0.0 pepN 3.4.11.2 E aminopeptidase
HGMOLFCO_00939 8.1e-196 1.1.1.1, 1.1.1.14 E alcohol dehydrogenase
HGMOLFCO_00940 2.1e-48 S Mazg nucleotide pyrophosphohydrolase
HGMOLFCO_00941 9.9e-49 rplR J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HGMOLFCO_00942 2.6e-86 rpsE J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HGMOLFCO_00943 6.5e-24 rpmD J Ribosomal protein L30
HGMOLFCO_00944 5.6e-66 rplO J Binds to the 23S rRNA
HGMOLFCO_00945 2.6e-236 secY U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
HGMOLFCO_00946 2.4e-121 adk 2.7.4.3 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
HGMOLFCO_00947 2e-32 infA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HGMOLFCO_00948 1.1e-13 rpmJ J Belongs to the bacterial ribosomal protein bL36 family
HGMOLFCO_00949 9.5e-59 rpsM J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HGMOLFCO_00950 1e-63 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HGMOLFCO_00951 2e-169 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HGMOLFCO_00952 2.8e-61 rplQ J Ribosomal protein L17
HGMOLFCO_00953 4.6e-149 cbiO P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HGMOLFCO_00954 4.4e-155 ecfA2 3.6.3.55 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HGMOLFCO_00955 4.1e-139 ecfT U Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HGMOLFCO_00956 2.2e-145 truA 5.4.99.12 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
HGMOLFCO_00957 2.6e-79 rplM J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HGMOLFCO_00958 1.5e-65 rpsI J Belongs to the universal ribosomal protein uS9 family
HGMOLFCO_00959 3e-188 S interspecies interaction between organisms
HGMOLFCO_00960 1.2e-138 IQ reductase
HGMOLFCO_00961 5.8e-109 acmC 3.2.1.17, 3.2.1.96 NU mannosyl-glycoprotein
HGMOLFCO_00962 3.2e-101 xpt 2.4.2.22, 2.4.2.7 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
HGMOLFCO_00963 1.4e-220 purK2 6.3.4.18 F Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HGMOLFCO_00964 0.0 pcrA 3.6.4.12 L ATP-dependent DNA helicase
HGMOLFCO_00965 0.0 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HGMOLFCO_00966 2.2e-167 camS S sex pheromone
HGMOLFCO_00967 1e-48 gatC 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HGMOLFCO_00968 3e-273 gatA 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
HGMOLFCO_00969 5e-273 gatB 6.1.1.12, 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HGMOLFCO_00970 1.9e-186 yegS 2.7.1.107 G Lipid kinase
HGMOLFCO_00971 6.3e-265 rumA 2.1.1.190 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HGMOLFCO_00972 1.1e-49 K TRANSCRIPTIONal
HGMOLFCO_00980 3e-07 K Bacterial regulatory proteins, tetR family
HGMOLFCO_00982 3.8e-11 qacC P COG2076 Membrane transporters of cations and cationic drugs
HGMOLFCO_00983 9e-142 ET Bacterial periplasmic substrate-binding proteins
HGMOLFCO_00984 2e-110 XK27_05795 P ABC transporter permease
HGMOLFCO_00985 0.0 nrdD 1.1.98.6 F Ribonucleoside-triphosphate reductase
HGMOLFCO_00986 2.4e-112 nrdG 1.97.1.4 O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HGMOLFCO_00987 5.4e-161 sufD O Uncharacterized protein family (UPF0051)
HGMOLFCO_00988 5.1e-235 F Permease
HGMOLFCO_00989 1.1e-200 adh 1.1.1.1, 1.1.1.14 C Zinc-binding dehydrogenase
HGMOLFCO_00990 1.1e-62 lytE M LysM domain protein
HGMOLFCO_00991 4.8e-85 ykhA 3.1.2.20 I Thioesterase superfamily
HGMOLFCO_00992 1.4e-77 hsp O Belongs to the small heat shock protein (HSP20) family
HGMOLFCO_00993 0.0 pacL 3.6.3.8, 3.6.3.9 P Cation transporter/ATPase, N-terminus
HGMOLFCO_00995 3.1e-114
HGMOLFCO_00996 4.7e-105 S Domain of unknown function (DUF4767)
HGMOLFCO_00997 4.7e-54 K Helix-turn-helix domain
HGMOLFCO_00998 1.8e-173 1.3.1.9 S Nitronate monooxygenase
HGMOLFCO_01000 1.5e-76 rocF 3.5.3.1, 3.5.3.11 E Arginase family
HGMOLFCO_01001 1.4e-50 ybjQ S Belongs to the UPF0145 family
HGMOLFCO_01002 5.3e-281 yjeM E Amino Acid
HGMOLFCO_01003 4e-43 K helix_turn _helix lactose operon repressor
HGMOLFCO_01004 3.1e-125 K helix_turn _helix lactose operon repressor
HGMOLFCO_01005 9.8e-261 G PTS system Galactitol-specific IIC component
HGMOLFCO_01006 9.3e-175 rbsK 2.7.1.15 H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HGMOLFCO_01007 1.5e-199 S Domain of unknown function (DUF4432)
HGMOLFCO_01008 2.8e-114 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HGMOLFCO_01009 3.7e-171 deoR K sugar-binding domain protein
HGMOLFCO_01010 2.2e-165 rbsK 2.7.1.15 H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HGMOLFCO_01011 2.1e-67 rbsD 5.4.99.62 G Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose
HGMOLFCO_01012 2.7e-244 fucP G Major Facilitator Superfamily
HGMOLFCO_01013 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HGMOLFCO_01014 1e-11 L PFAM transposase, IS4 family protein
HGMOLFCO_01015 3.3e-90 L PFAM transposase, IS4 family protein
HGMOLFCO_01016 2.1e-123 K Crp-like helix-turn-helix domain
HGMOLFCO_01017 6.8e-237 larA 5.1.2.1 S Domain of unknown function (DUF2088)
HGMOLFCO_01018 7.9e-132 cpmA S AIR carboxylase
HGMOLFCO_01019 7.3e-228 larC 4.99.1.12 S Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HGMOLFCO_01020 3.3e-147 larE S NAD synthase
HGMOLFCO_01021 1.7e-122 glpF U Belongs to the MIP aquaporin (TC 1.A.8) family
HGMOLFCO_01022 4.1e-173 hoxN U High-affinity nickel-transport protein
HGMOLFCO_01023 0.0 polC 2.7.7.7 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HGMOLFCO_01024 4.1e-217 argD 2.6.1.11, 2.6.1.17 E acetylornithine
HGMOLFCO_01025 1e-136 argB 2.7.2.8 F Belongs to the acetylglutamate kinase family. ArgB subfamily
HGMOLFCO_01026 6.2e-208 argJ 2.3.1.1, 2.3.1.35, 2.7.2.8 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HGMOLFCO_01027 4.2e-197 argC 1.2.1.38 E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HGMOLFCO_01028 2.3e-206 carA 6.3.5.5 F Carbamoyl-phosphate synthetase glutamine chain
HGMOLFCO_01029 0.0 carB 6.3.5.5 F Carbamoyl-phosphate synthase
HGMOLFCO_01030 3.3e-83 rimP J Required for maturation of 30S ribosomal subunits
HGMOLFCO_01031 8.3e-224 nusA K Participates in both transcription termination and antitermination
HGMOLFCO_01032 1.4e-47 ylxR K Protein of unknown function (DUF448)
HGMOLFCO_01033 9.3e-50 ylxQ J ribosomal protein
HGMOLFCO_01034 0.0 infB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HGMOLFCO_01035 4.2e-59 rbfA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HGMOLFCO_01036 5.7e-166 truB 5.4.99.25 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HGMOLFCO_01037 2.3e-184 ribF 2.7.1.26, 2.7.7.2 H Belongs to the ribF family
HGMOLFCO_01038 9.3e-248 EGP Major facilitator Superfamily
HGMOLFCO_01039 7.3e-141 hisF 3.5.4.19, 3.6.1.31 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
HGMOLFCO_01040 1.3e-128 hisA 5.3.1.16 E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HGMOLFCO_01041 1.2e-111 hisH E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HGMOLFCO_01042 1.3e-102 hisB 1.1.1.23, 2.6.1.9, 3.1.3.15, 4.2.1.19 E imidazoleglycerol-phosphate dehydratase
HGMOLFCO_01043 2.6e-228 hisD 1.1.1.23, 1.1.1.308 E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HGMOLFCO_01044 5.8e-109 hisG 2.4.2.17 F Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
HGMOLFCO_01045 3.8e-218 hisZ 2.4.2.17, 6.1.1.21 E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HGMOLFCO_01046 1.3e-167 hisK 3.1.3.15 E Histidinol phosphate phosphatase, HisJ
HGMOLFCO_01047 8.5e-51 hisF 3.5.4.19, 3.6.1.31 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
HGMOLFCO_01048 1.6e-08 hisF 3.5.4.19, 3.6.1.31 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
HGMOLFCO_01049 2.8e-50 hisH E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HGMOLFCO_01050 7.2e-177 dnaJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
HGMOLFCO_01051 0.0 dnaK O Heat shock 70 kDa protein
HGMOLFCO_01052 5.6e-61 grpE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HGMOLFCO_01053 2.2e-193 hrcA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
HGMOLFCO_01054 1.1e-62
HGMOLFCO_01055 5e-56 arsC 1.20.4.1 T Low molecular weight phosphotyrosine protein phosphatase
HGMOLFCO_01057 9.2e-217 argE 3.5.1.18 E succinyl-diaminopimelate desuccinylase
HGMOLFCO_01058 3.9e-259 guaD 3.5.4.3 F Amidohydrolase family
HGMOLFCO_01059 7.7e-175 tdh 1.1.1.14 C Zinc-binding dehydrogenase
HGMOLFCO_01060 1.1e-30 S Sugar efflux transporter for intercellular exchange
HGMOLFCO_01061 8e-32 higA K Helix-turn-helix XRE-family like proteins
HGMOLFCO_01062 9.8e-136 E Amino acid permease
HGMOLFCO_01063 1e-238 gadB 4.1.1.15 E Belongs to the group II decarboxylase family
HGMOLFCO_01064 8.3e-16
HGMOLFCO_01065 2.9e-103 dedA S SNARE-like domain protein
HGMOLFCO_01066 5.7e-25 S Protein of unknown function (DUF1461)
HGMOLFCO_01067 6.6e-142 nagD 2.7.1.25, 3.1.3.41 G Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
HGMOLFCO_01068 1.2e-97 yutD S Protein of unknown function (DUF1027)
HGMOLFCO_01069 5.3e-110 S Calcineurin-like phosphoesterase
HGMOLFCO_01070 2.1e-224 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HGMOLFCO_01071 3.9e-159 ytxK 2.1.1.72 L N-6 DNA Methylase
HGMOLFCO_01073 1.7e-14
HGMOLFCO_01075 2.3e-15 NU general secretion pathway protein
HGMOLFCO_01076 1.1e-47 comGC U competence protein ComGC
HGMOLFCO_01077 1e-158 comGB NU type II secretion system
HGMOLFCO_01078 7e-178 comGA NU Type II IV secretion system protein
HGMOLFCO_01079 0.0 ykcB M Dolichyl-phosphate-mannose-protein mannosyltransferase
HGMOLFCO_01080 8.3e-84 mltD CBM50 M PFAM NLP P60 protein
HGMOLFCO_01081 3.7e-134 yebC K Transcriptional regulatory protein
HGMOLFCO_01082 3.6e-85
HGMOLFCO_01083 7.4e-186 ccpA K catabolite control protein A
HGMOLFCO_01084 9.1e-214 pepQ 3.4.13.9 E Creatinase/Prolidase N-terminal domain
HGMOLFCO_01085 8.5e-70
HGMOLFCO_01086 9.2e-26 WQ51_05790 S protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HGMOLFCO_01087 6.2e-157 ykuT M mechanosensitive ion channel
HGMOLFCO_01088 3.8e-151 3.1.3.102, 3.1.3.104, 3.1.3.23 S haloacid dehalogenase-like hydrolase
HGMOLFCO_01089 1.4e-95 S Phosphoesterase
HGMOLFCO_01090 3.6e-108 rdgB 3.6.1.66, 5.1.1.3 F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HGMOLFCO_01091 5.4e-147 murI 3.6.1.66, 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
HGMOLFCO_01092 1.3e-91 yslB S Protein of unknown function (DUF2507)
HGMOLFCO_01093 1e-224 clcA_2 P Chloride transporter, ClC family
HGMOLFCO_01094 1.4e-53 trxA O Belongs to the thioredoxin family
HGMOLFCO_01095 3e-187 argF 2.1.3.3 E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HGMOLFCO_01096 1e-165 arcC 2.7.2.2 E Belongs to the carbamate kinase family
HGMOLFCO_01097 9.1e-239 arcA 3.5.3.6 E Arginine
HGMOLFCO_01098 3.5e-258 E Arginine ornithine antiporter
HGMOLFCO_01099 2.7e-221 yxjG 2.1.1.14 E methionine synthase, vitamin-B12 independent
HGMOLFCO_01100 8.7e-215 arcT 2.6.1.1 E Aminotransferase
HGMOLFCO_01101 1.1e-169 apbE 2.7.1.180 H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
HGMOLFCO_01102 1.8e-179 dapF 5.1.1.7 E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HGMOLFCO_01103 7.7e-263 lysC 2.7.2.4 E Belongs to the aspartokinase family
HGMOLFCO_01104 2.4e-253 lysA 4.1.1.19, 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
HGMOLFCO_01105 2.9e-72 dapD 2.3.1.117, 2.3.1.89 E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
HGMOLFCO_01106 1.8e-220 hipO 3.5.1.47 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
HGMOLFCO_01107 9.2e-175 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HGMOLFCO_01108 2.8e-140 dapB 1.17.1.8 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
HGMOLFCO_01109 6.5e-218 patA 2.6.1.1 E Aminotransferase
HGMOLFCO_01110 1.5e-197 asd 1.2.1.11 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HGMOLFCO_01111 3e-227 ktrB P Potassium uptake protein
HGMOLFCO_01112 7.5e-118 ktrA P domain protein
HGMOLFCO_01113 1.7e-125 trmK 2.1.1.217 S SAM-dependent methyltransferase
HGMOLFCO_01114 1.7e-156 yqfO 3.5.4.16 S Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HGMOLFCO_01115 6.6e-237 pepT 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
HGMOLFCO_01117 0.0 dnaE 2.7.7.7 L DNA polymerase
HGMOLFCO_01118 8.3e-268 pyk 2.7.1.40, 2.7.7.4 G Belongs to the pyruvate kinase family
HGMOLFCO_01119 1.6e-168 cvfB S S1 domain
HGMOLFCO_01120 6e-160 xerD D recombinase XerD
HGMOLFCO_01121 3.1e-93 P Cadmium resistance transporter
HGMOLFCO_01122 4.6e-32 ydzE EG spore germination
HGMOLFCO_01123 6.5e-54 4.1.1.44 O Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HGMOLFCO_01124 4.9e-46
HGMOLFCO_01125 2.1e-255 isdH M Iron Transport-associated domain
HGMOLFCO_01126 1e-94 M Iron Transport-associated domain
HGMOLFCO_01127 2.8e-149 isdE P Periplasmic binding protein
HGMOLFCO_01128 7.5e-153 isdF U Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HGMOLFCO_01129 4.2e-141 fhuC 3.6.3.34 HP ABC transporter, ATP-binding protein
HGMOLFCO_01130 2.2e-235 kgtP EGP Sugar (and other) transporter
HGMOLFCO_01131 2.2e-57
HGMOLFCO_01132 4.9e-159 xth 3.1.11.2 L exodeoxyribonuclease III
HGMOLFCO_01133 4.3e-172 L PFAM Integrase, catalytic core
HGMOLFCO_01134 1.2e-219 iscS 2.8.1.7 E Aminotransferase class V
HGMOLFCO_01136 1.2e-71 tkt 2.2.1.1 H Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HGMOLFCO_01137 2.6e-18 tkt 2.2.1.1 H Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HGMOLFCO_01138 1.4e-12 tkt 2.2.1.1 H Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HGMOLFCO_01139 1.7e-125 rpiA 2.7.1.12, 5.3.1.6 G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HGMOLFCO_01140 2.3e-136 tal 2.2.1.2 H Transaldolase/Fructose-6-phosphate aldolase
HGMOLFCO_01141 0.0 tkt 2.2.1.1 H Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HGMOLFCO_01142 5.5e-245 glpT G Major Facilitator Superfamily
HGMOLFCO_01143 2.4e-128 qmcA O prohibitin homologues
HGMOLFCO_01145 3.1e-75 uspA T universal stress protein
HGMOLFCO_01146 2.1e-59
HGMOLFCO_01147 6.6e-20
HGMOLFCO_01148 1.7e-159
HGMOLFCO_01149 8.4e-75 K Transcriptional regulator
HGMOLFCO_01150 1.1e-186 D Alpha beta
HGMOLFCO_01151 1.6e-73 O OsmC-like protein
HGMOLFCO_01152 3.4e-191 lplA2 6.3.1.20 H Bacterial lipoate protein ligase C-terminus
HGMOLFCO_01153 0.0 yjcE P Sodium proton antiporter
HGMOLFCO_01154 1.2e-16 yvlA
HGMOLFCO_01155 1.4e-113 P Cobalt transport protein
HGMOLFCO_01156 3.7e-257 cbiO1 S ABC transporter, ATP-binding protein
HGMOLFCO_01157 1.6e-100 S ABC-type cobalt transport system, permease component
HGMOLFCO_01158 2e-180 iunH2 3.2.2.1 F nucleoside hydrolase
HGMOLFCO_01159 4.4e-183 yumC 1.18.1.2, 1.19.1.1, 1.8.1.9 C Ferredoxin--NADP reductase
HGMOLFCO_01160 0.0 cadA 3.6.3.3, 3.6.3.5 P P-type ATPase
HGMOLFCO_01161 2.8e-32 copZ P Heavy-metal-associated domain
HGMOLFCO_01162 3.4e-100 dps P Belongs to the Dps family
HGMOLFCO_01163 1.8e-108 rcfA 4.1.99.16, 4.2.3.22, 4.2.3.75 K helix_turn_helix, cAMP Regulatory protein
HGMOLFCO_01164 2e-85
HGMOLFCO_01165 0.0 ltaS 2.7.8.20 M Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
HGMOLFCO_01166 2.5e-126 pgm3 G phosphoglycerate mutase family
HGMOLFCO_01167 1.9e-150 qorB 1.6.5.2 GM NmrA-like family
HGMOLFCO_01168 9.3e-229 pbuX F xanthine permease
HGMOLFCO_01169 1e-170 corA P CorA-like Mg2+ transporter protein
HGMOLFCO_01170 9.3e-169 rluA 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
HGMOLFCO_01171 2.3e-142 terC P membrane
HGMOLFCO_01172 1e-56 trxA1 O Belongs to the thioredoxin family
HGMOLFCO_01173 9.1e-164 fadB4 1.1.1.157 I 3-hydroxyacyl-CoA dehydrogenase
HGMOLFCO_01174 2.6e-163 endA F DNA RNA non-specific endonuclease
HGMOLFCO_01175 4e-267 pipD E Dipeptidase
HGMOLFCO_01177 7.8e-255 yifK E Amino acid permease
HGMOLFCO_01179 0.0 dxs 2.2.1.7 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HGMOLFCO_01180 2.7e-238 N Uncharacterized conserved protein (DUF2075)
HGMOLFCO_01181 1.6e-12 S SNARE associated Golgi protein
HGMOLFCO_01182 2.7e-24 S SNARE associated Golgi protein
HGMOLFCO_01183 2.2e-78 ndk 2.7.4.6 F Belongs to the NDK family
HGMOLFCO_01184 1.8e-68 padR K Virulence activator alpha C-term
HGMOLFCO_01186 4.4e-216 I transferase activity, transferring acyl groups other than amino-acyl groups
HGMOLFCO_01188 1.6e-131 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HGMOLFCO_01189 1.8e-223 patA 2.6.1.1, 2.6.1.57 E Aminotransferase
HGMOLFCO_01190 1.9e-178
HGMOLFCO_01191 4.2e-46 silP 1.9.3.1, 3.6.3.54 S Cupredoxin-like domain
HGMOLFCO_01192 3.3e-52 silP 1.9.3.1, 3.6.3.54 S Cupredoxin-like domain
HGMOLFCO_01193 0.0 copA 3.6.3.54 P P-type ATPase
HGMOLFCO_01194 3.4e-18 EGP Major facilitator Superfamily
HGMOLFCO_01195 3.9e-89 2.4.2.6 F nucleoside 2-deoxyribosyltransferase
HGMOLFCO_01196 2.5e-147 KT YcbB domain
HGMOLFCO_01197 1e-192 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
HGMOLFCO_01198 2.3e-173 ppx 3.6.1.11, 3.6.1.40 FP exopolyphosphatase
HGMOLFCO_01199 0.0 ppk 2.7.4.1 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HGMOLFCO_01200 1.9e-283 ppx3 3.6.1.11, 3.6.1.40 FP exopolyphosphatase
HGMOLFCO_01201 7.3e-146 fat 3.1.2.21 I Acyl-ACP thioesterase
HGMOLFCO_01202 1.2e-157 rsmI 2.1.1.198 H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HGMOLFCO_01203 1.5e-55 yabA L Involved in initiation control of chromosome replication
HGMOLFCO_01204 6.2e-70 holB 2.7.7.7 L DNA polymerase III
HGMOLFCO_01205 5.6e-36 gshF 6.3.2.2 H Belongs to the glutamate--cysteine ligase type 1 family
HGMOLFCO_01206 0.0 rnjB J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HGMOLFCO_01207 3.5e-163 S Tetratricopeptide repeat
HGMOLFCO_01208 4.3e-225 tuf J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HGMOLFCO_01209 5.7e-215 tig D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
HGMOLFCO_01210 1.5e-233 clpX O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HGMOLFCO_01211 2.3e-107 engB D Necessary for normal cell division and for the maintenance of normal septation
HGMOLFCO_01212 8.3e-53 MA20_27270 S mazG nucleotide pyrophosphohydrolase
HGMOLFCO_01214 3.3e-135 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
HGMOLFCO_01215 0.0 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
HGMOLFCO_01216 6.7e-248 obg S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HGMOLFCO_01217 3.2e-175 rnz 3.1.26.11 J Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
HGMOLFCO_01218 1.9e-155 XK27_05435 1.1.1.100 S Belongs to the short-chain dehydrogenases reductases (SDR) family
HGMOLFCO_01219 0.0 recJ L Single-stranded-DNA-specific exonuclease RecJ
HGMOLFCO_01220 2.4e-95 apt 2.4.2.22, 2.4.2.7 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HGMOLFCO_01221 9.3e-59 S Domain of unknown function (DUF4440)
HGMOLFCO_01222 8.2e-100 P Cadmium resistance transporter
HGMOLFCO_01223 3.2e-116 S Protein of unknown function (DUF554)
HGMOLFCO_01224 8.4e-104 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HGMOLFCO_01225 5.5e-158 P Belongs to the nlpA lipoprotein family
HGMOLFCO_01226 3.9e-98 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HGMOLFCO_01227 6.4e-38 V CAAX protease self-immunity
HGMOLFCO_01228 2.3e-67 psiE S Phosphate-starvation-inducible E
HGMOLFCO_01229 1.5e-149 thiD 2.5.1.3, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Phosphomethylpyrimidine kinase
HGMOLFCO_01230 1.7e-111 thiE 2.5.1.3 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
HGMOLFCO_01231 7.2e-144 thiD 2.5.1.3, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Phosphomethylpyrimidine kinase
HGMOLFCO_01232 8.7e-139 thiM 2.7.1.50 H Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HGMOLFCO_01233 0.0 M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HGMOLFCO_01234 0.0 cas9 L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
HGMOLFCO_01235 2.5e-92 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HGMOLFCO_01236 3.2e-34 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HGMOLFCO_01237 1.9e-36 S CRISPR-associated protein (Cas_Csn2)
HGMOLFCO_01239 2.1e-33 aes I Hydrolase, alpha beta domain protein
HGMOLFCO_01240 6e-35 aes I Carboxylesterase family
HGMOLFCO_01242 7.1e-97 S integral membrane protein
HGMOLFCO_01243 1.5e-172 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
HGMOLFCO_01245 1.2e-54
HGMOLFCO_01246 4.9e-176 prmA J Ribosomal protein L11 methyltransferase
HGMOLFCO_01247 2e-135 rsmE 2.1.1.193 J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
HGMOLFCO_01248 4.4e-58
HGMOLFCO_01249 0.0 relA 2.7.6.5 KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HGMOLFCO_01250 2.4e-77 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
HGMOLFCO_01251 3.5e-85 slyA K Transcriptional regulator
HGMOLFCO_01252 2.3e-218 metC1 2.5.1.48, 4.4.1.8 E cystathionine
HGMOLFCO_01253 3.3e-211 metB 2.5.1.48, 4.4.1.8 E Cys/Met metabolism PLP-dependent enzyme
HGMOLFCO_01255 3.1e-67 yxeM ET Bacterial periplasmic substrate-binding proteins
HGMOLFCO_01256 9.2e-47 yxeL K acetyltransferase
HGMOLFCO_01257 2.2e-70 yxeN U ABC transporter, permease protein
HGMOLFCO_01258 1.2e-78 yxeO 3.6.3.21 E ATPases associated with a variety of cellular activities
HGMOLFCO_01259 1.7e-146 3.5.1.47 E Peptidase dimerisation domain
HGMOLFCO_01260 1.1e-171 pcaB 4.3.2.2 F Adenylosuccinate lyase C-terminus
HGMOLFCO_01261 3.9e-91 yxeQ S MmgE/PrpD family
HGMOLFCO_01263 4.2e-113 papP P ABC transporter, permease protein
HGMOLFCO_01264 2e-115 P ABC transporter permease
HGMOLFCO_01265 3.9e-136 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
HGMOLFCO_01266 3.1e-153 cjaA ET ABC transporter substrate-binding protein
HGMOLFCO_01267 6.1e-137 IQ KR domain
HGMOLFCO_01268 4e-212 hom1 1.1.1.3 E Homoserine dehydrogenase
HGMOLFCO_01269 2.4e-158 metAA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to
HGMOLFCO_01270 3.6e-54 yphJ 4.1.1.44 S decarboxylase
HGMOLFCO_01271 2.8e-54 azlD E Branched-chain amino acid transport
HGMOLFCO_01272 9.8e-121 azlC E azaleucine resistance protein AzlC
HGMOLFCO_01273 1.9e-286 thrC 4.2.3.1 E Threonine synthase
HGMOLFCO_01274 3.5e-233 hom 1.1.1.3, 2.7.2.4 E homoserine dehydrogenase
HGMOLFCO_01275 8e-157 thrB 2.7.1.39 F Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
HGMOLFCO_01276 3.5e-99 K Acetyltransferase (GNAT) domain
HGMOLFCO_01277 5.3e-113 ylbE GM NAD(P)H-binding
HGMOLFCO_01278 1.5e-118 ypgQ S Metal dependent phosphohydrolases with conserved 'HD' motif.
HGMOLFCO_01279 1.8e-133 S Belongs to the UPF0246 family
HGMOLFCO_01280 1.3e-97
HGMOLFCO_01281 5.5e-161 degV S EDD domain protein, DegV family
HGMOLFCO_01282 0.0 FbpA K Fibronectin-binding protein
HGMOLFCO_01284 5.1e-89
HGMOLFCO_01285 1.3e-78 F Nucleoside 2-deoxyribosyltransferase
HGMOLFCO_01286 6.7e-184 scrR3 K Transcriptional regulator, LacI family
HGMOLFCO_01287 2.8e-12
HGMOLFCO_01288 2.4e-16 hbd2 1.1.1.157 I 3-hydroxyacyl-CoA dehydrogenase
HGMOLFCO_01289 1.1e-06 M domain protein
HGMOLFCO_01291 4.1e-12 S CHY zinc finger
HGMOLFCO_01293 0.0 asnB 6.3.5.4 E Aluminium induced protein
HGMOLFCO_01295 1.4e-190 EGP Major facilitator Superfamily
HGMOLFCO_01298 1.1e-103 S Bacterial transferase hexapeptide (six repeats)
HGMOLFCO_01299 6e-120 IQ Enoyl-(Acyl carrier protein) reductase
HGMOLFCO_01300 3.7e-199 gldA 1.1.1.6 C dehydrogenase
HGMOLFCO_01301 2.3e-11 xre K Helix-turn-helix domain
HGMOLFCO_01302 2.1e-51 S Sugar efflux transporter for intercellular exchange
HGMOLFCO_01303 1.1e-179 S AI-2E family transporter
HGMOLFCO_01304 8.8e-215 phbA 2.3.1.9 I Belongs to the thiolase family
HGMOLFCO_01305 3.5e-160 rssA S Phospholipase, patatin family
HGMOLFCO_01306 7.5e-169 K LysR substrate binding domain
HGMOLFCO_01307 0.0 1.3.5.4 C FAD binding domain
HGMOLFCO_01308 1.3e-73 S Domain of unknown function (DUF4352)
HGMOLFCO_01309 6.8e-114 yicL EG EamA-like transporter family
HGMOLFCO_01310 6.3e-63
HGMOLFCO_01313 1.7e-35
HGMOLFCO_01314 4.1e-68 S pyridoxamine 5-phosphate
HGMOLFCO_01315 2.8e-179 yobV1 K WYL domain
HGMOLFCO_01316 7.9e-244 XK27_08635 S UPF0210 protein
HGMOLFCO_01317 2.5e-40 gcvR T Belongs to the UPF0237 family
HGMOLFCO_01318 1.3e-168 mccA 2.5.1.134, 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
HGMOLFCO_01319 7.5e-211 metC 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
HGMOLFCO_01320 1.9e-208 adh 1.1.1.1, 1.1.1.14 C Zinc-binding dehydrogenase
HGMOLFCO_01321 1.7e-218 G Transporter, major facilitator family protein
HGMOLFCO_01322 3.4e-277 menE 6.2.1.26 H Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily
HGMOLFCO_01323 5.3e-158 menB 4.1.3.36 H Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HGMOLFCO_01324 2.7e-56 ydiI Q Thioesterase superfamily
HGMOLFCO_01325 5.5e-61 birA 6.3.4.15 H Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
HGMOLFCO_01326 0.0 pyc 6.4.1.1 C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HGMOLFCO_01327 1.4e-162 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
HGMOLFCO_01329 2.6e-184 adhC 1.1.1.90 C Zn-dependent alcohol dehydrogenases, class III
HGMOLFCO_01330 4.3e-91 citR K sugar-binding domain protein
HGMOLFCO_01331 4.8e-138 citG 2.4.2.52, 2.7.7.61 H 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase
HGMOLFCO_01332 3.2e-42 ydjP I Alpha/beta hydrolase family
HGMOLFCO_01333 2.3e-107 L Integrase
HGMOLFCO_01334 3.3e-45 K transcriptional regulator
HGMOLFCO_01335 2.7e-109 GM NmrA-like family
HGMOLFCO_01336 1.1e-24 C Flavodoxin
HGMOLFCO_01337 9.9e-241 purD 6.3.4.13 F Belongs to the GARS family
HGMOLFCO_01338 3.8e-295 purH 2.1.2.3, 3.5.4.10 F Bifunctional purine biosynthesis protein PurH
HGMOLFCO_01339 2.3e-107 purN 2.1.2.2 F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HGMOLFCO_01340 1.1e-197 purM 6.3.3.1, 6.3.4.13 F Phosphoribosylformylglycinamidine cyclo-ligase
HGMOLFCO_01341 2.6e-280 purF 2.4.2.14 F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HGMOLFCO_01342 0.0 purL 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HGMOLFCO_01343 8e-128 purQ 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HGMOLFCO_01344 6.8e-37 purS 6.3.2.6, 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HGMOLFCO_01345 6.5e-136 purC 4.1.1.21, 4.3.2.2, 6.3.2.6 F Belongs to the SAICAR synthetase family
HGMOLFCO_01346 2.1e-13 nagZ 3.2.1.52 G Glycosyl hydrolase family 3 N terminal domain
HGMOLFCO_01347 6.3e-237 S response to antibiotic
HGMOLFCO_01348 2.1e-172 hrpQ 4.6.1.1 T histone H2A K63-linked ubiquitination
HGMOLFCO_01349 1.2e-254 purB 4.3.2.2 F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HGMOLFCO_01350 7.7e-216 purK 6.3.4.18 F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HGMOLFCO_01351 4e-81 purE 5.4.99.18 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HGMOLFCO_01352 0.0 fhs 6.3.4.3 F Belongs to the formate--tetrahydrofolate ligase family
HGMOLFCO_01353 4.8e-164 K AI-2E family transporter
HGMOLFCO_01354 3.1e-10 K transcriptional regulator
HGMOLFCO_01355 7.5e-39 S Sugar efflux transporter for intercellular exchange
HGMOLFCO_01356 4.1e-113 flp 4.1.99.16, 4.2.3.22, 4.2.3.75 K Transcriptional regulator, Crp Fnr family
HGMOLFCO_01357 5.4e-46 D Di-iron-containing protein involved in the repair of iron-sulfur clusters
HGMOLFCO_01358 5.6e-33 copZ P Heavy-metal-associated domain
HGMOLFCO_01359 0.0 cadA 3.6.3.3, 3.6.3.5 P E1-E2 ATPase
HGMOLFCO_01360 9.8e-82
HGMOLFCO_01361 0.0 alsS 2.2.1.6 EH Belongs to the TPP enzyme family
HGMOLFCO_01362 0.0 N Uncharacterized conserved protein (DUF2075)
HGMOLFCO_01364 6.9e-101 K DNA-templated transcription, initiation
HGMOLFCO_01365 1.1e-56 arsD S Arsenical resistance operon trans-acting repressor ArsD
HGMOLFCO_01366 2.7e-233 arsB U Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HGMOLFCO_01367 2.2e-216 S CAAX protease self-immunity
HGMOLFCO_01368 0.0 rnjA J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HGMOLFCO_01369 2e-58
HGMOLFCO_01370 1.9e-74 merR K MerR HTH family regulatory protein
HGMOLFCO_01371 6.6e-268 lmrB EGP Major facilitator Superfamily
HGMOLFCO_01372 2.4e-114 S Domain of unknown function (DUF4811)
HGMOLFCO_01373 8.5e-150 araA 5.3.1.4 G Catalyzes the conversion of L-arabinose to L-ribulose
HGMOLFCO_01374 2.3e-93 L Helix-turn-helix domain
HGMOLFCO_01375 1.9e-115 L PFAM Integrase catalytic region
HGMOLFCO_01376 1.7e-170 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 J Responsible for synthesis of pseudouridine from uracil
HGMOLFCO_01378 0.0 mprF 2.3.2.3 S Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HGMOLFCO_01379 2.7e-108 thiJ 2.7.11.1, 3.5.1.124 S DJ-1/PfpI family
HGMOLFCO_01380 2.4e-189 I Alpha beta
HGMOLFCO_01381 2.5e-121 ung2 3.2.2.27 L Uracil-DNA glycosylase
HGMOLFCO_01382 1.9e-253 yjjP S Putative threonine/serine exporter
HGMOLFCO_01383 3.8e-162 mleR K LysR family transcriptional regulator
HGMOLFCO_01384 1.9e-224 yflS P Sodium:sulfate symporter transmembrane region
HGMOLFCO_01385 8e-215 frdC 1.3.5.4 C FAD binding domain
HGMOLFCO_01386 6.1e-223 fumC 4.2.1.2 C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
HGMOLFCO_01387 1.9e-91 XK27_09620 S NADPH-dependent FMN reductase
HGMOLFCO_01388 1.9e-181 XK27_09615 S reductase
HGMOLFCO_01389 1.4e-229 sfcA 1.1.1.38, 4.1.1.101 C Malic enzyme
HGMOLFCO_01390 1.1e-79 mleR K LysR family
HGMOLFCO_01391 1.3e-52 nlhH_1 I Carboxylesterase family
HGMOLFCO_01392 1e-107 ppiB 5.2.1.8 G PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HGMOLFCO_01393 0.0 scrA 2.7.1.211, 5.3.1.1 G phosphotransferase system
HGMOLFCO_01394 1e-195 adhA 1.1.1.1 C Zinc-binding alcohol dehydrogenase family protein
HGMOLFCO_01395 4.5e-301 scrB 3.2.1.26 GH32 G invertase
HGMOLFCO_01396 7.3e-261 S Uncharacterized protein conserved in bacteria (DUF2252)
HGMOLFCO_01397 3.2e-164 K LysR substrate binding domain
HGMOLFCO_01398 6.8e-164 S Polyphosphate nucleotide phosphotransferase, PPK2 family
HGMOLFCO_01399 5.5e-112
HGMOLFCO_01401 9e-265 yjeM E Amino Acid
HGMOLFCO_01402 2.2e-148 ponA V Beta-lactamase enzyme family
HGMOLFCO_01403 1.7e-224 dacA 3.4.16.4 M Belongs to the peptidase S11 family
HGMOLFCO_01404 1.3e-96
HGMOLFCO_01405 5.9e-199 pgl 3.1.1.31 G Lactonase, 7-bladed beta-propeller
HGMOLFCO_01406 4.7e-108 lssY 3.6.1.27 I Acid phosphatase homologues
HGMOLFCO_01407 1.6e-54 S MazG-like family
HGMOLFCO_01408 0.0 L Helicase C-terminal domain protein
HGMOLFCO_01409 2.2e-72 nudG 3.6.1.55, 3.6.1.65 L NUDIX domain
HGMOLFCO_01410 7.7e-97 K transcriptional regulator
HGMOLFCO_01411 5.9e-137 lmrB EGP Major facilitator Superfamily
HGMOLFCO_01413 4.4e-12 yfjR K Psort location Cytoplasmic, score
HGMOLFCO_01414 1e-37 S Cytochrome B5
HGMOLFCO_01415 3e-89 luxS 4.4.1.21 H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
HGMOLFCO_01416 6.4e-215 2.1.1.14 E methionine synthase, vitamin-B12 independent
HGMOLFCO_01417 8.1e-33 elaA S GNAT family
HGMOLFCO_01418 4.5e-85 usp1 T Belongs to the universal stress protein A family
HGMOLFCO_01419 2.2e-109 S VIT family
HGMOLFCO_01420 7.2e-116 S membrane
HGMOLFCO_01421 1.6e-163 czcD P cation diffusion facilitator family transporter
HGMOLFCO_01422 4.4e-123 sirR K iron dependent repressor
HGMOLFCO_01423 8.7e-30 cspA K Cold shock protein
HGMOLFCO_01424 6.3e-126 thrE S Putative threonine/serine exporter
HGMOLFCO_01425 2.8e-82 S Threonine/Serine exporter, ThrE
HGMOLFCO_01426 1.3e-114 lssY 3.6.1.27 I phosphatase
HGMOLFCO_01427 1.3e-156 I alpha/beta hydrolase fold
HGMOLFCO_01429 3.9e-268 lysP E amino acid
HGMOLFCO_01430 7.9e-117 dak 2.7.1.74, 2.7.1.76 F deoxynucleoside kinase
HGMOLFCO_01436 2e-11 IQ Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HGMOLFCO_01437 1.3e-45 IQ reductase
HGMOLFCO_01438 9.4e-147 uppP 3.6.1.27 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
HGMOLFCO_01439 3.7e-42 S ABC-type cobalt transport system, permease component
HGMOLFCO_01441 2.7e-120 J 2'-5' RNA ligase superfamily
HGMOLFCO_01442 4.3e-132 XK27_07210 6.1.1.6 S B3 4 domain
HGMOLFCO_01443 9.7e-194 adhP 1.1.1.1 C alcohol dehydrogenase
HGMOLFCO_01444 4.8e-79 ctsR K Belongs to the CtsR family
HGMOLFCO_01445 0.0 clpC O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
HGMOLFCO_01446 5.8e-106 K Bacterial regulatory proteins, tetR family
HGMOLFCO_01447 0.0 rpoB 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HGMOLFCO_01448 0.0 rpoC 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HGMOLFCO_01449 5.6e-135 puuD S peptidase C26
HGMOLFCO_01450 2.2e-213 ykiI
HGMOLFCO_01451 1.6e-32 pilD 3.4.23.43 NOU aspartic-type endopeptidase activity
HGMOLFCO_01452 3.2e-71 rpsL J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HGMOLFCO_01453 7.1e-83 rpsG J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
HGMOLFCO_01454 0.0 fusA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HGMOLFCO_01455 2.6e-49 rpsJ J Involved in the binding of tRNA to the ribosomes
HGMOLFCO_01456 8.7e-119 rplC J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HGMOLFCO_01457 8.8e-105 rplD J Forms part of the polypeptide exit tunnel
HGMOLFCO_01458 4.8e-45 rplW J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
HGMOLFCO_01459 3.2e-150 rplB J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HGMOLFCO_01460 8.4e-47 rpsS J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HGMOLFCO_01461 2.2e-52 rplV J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HGMOLFCO_01462 6.2e-117 rpsC J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HGMOLFCO_01463 6e-76 rplP J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HGMOLFCO_01464 1.1e-27 rpmC J Belongs to the universal ribosomal protein uL29 family
HGMOLFCO_01465 6.5e-41 rpsQ J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HGMOLFCO_01466 6.6e-60 rplN J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HGMOLFCO_01467 5.2e-50 rplX J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HGMOLFCO_01468 4.2e-95 rplE J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HGMOLFCO_01469 5.2e-29 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HGMOLFCO_01470 1e-66 rpsH J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HGMOLFCO_01471 3e-93 rplF J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HGMOLFCO_01472 1.1e-141 scpA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HGMOLFCO_01473 5e-102 scpB D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HGMOLFCO_01474 1.1e-130 rluB 5.4.99.19, 5.4.99.21, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
HGMOLFCO_01475 3.7e-81 U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HGMOLFCO_01476 5e-198 ypbB 5.1.3.1 S Helix-turn-helix domain
HGMOLFCO_01477 3.1e-278 recQ1 3.6.4.12 L ATP-dependent DNA helicase RecQ
HGMOLFCO_01478 9.7e-31 M Lysin motif
HGMOLFCO_01479 5.8e-118 cmk 1.17.7.4, 2.5.1.19, 2.7.1.26, 2.7.4.25, 2.7.7.2, 6.3.2.1 F Belongs to the cytidylate kinase family. Type 1 subfamily
HGMOLFCO_01480 5.8e-209 rpsA 1.17.7.4 J Ribosomal protein S1
HGMOLFCO_01481 7.4e-247 der 1.1.1.399, 1.1.1.95 S GTPase that plays an essential role in the late steps of ribosome biogenesis
HGMOLFCO_01482 4.4e-40 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
HGMOLFCO_01483 1.8e-234 S Tetratricopeptide repeat protein
HGMOLFCO_01484 4.7e-165 xerD L Phage integrase, N-terminal SAM-like domain
HGMOLFCO_01485 2.6e-222 cca 2.7.7.19, 2.7.7.72 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HGMOLFCO_01486 0.0 yfmR S ABC transporter, ATP-binding protein
HGMOLFCO_01487 2.1e-190 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HGMOLFCO_01488 3.3e-94 folA 1.5.1.3 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HGMOLFCO_01489 1.2e-109 hlyIII S protein, hemolysin III
HGMOLFCO_01490 2.4e-153 DegV S EDD domain protein, DegV family
HGMOLFCO_01491 2.9e-218 1.1.1.399, 1.1.1.95 EH D-isomer specific 2-hydroxyacid dehydrogenase
HGMOLFCO_01492 1.1e-107 cat S Bacterial transferase hexapeptide (six repeats)
HGMOLFCO_01493 1.1e-167 ypmR E lipolytic protein G-D-S-L family
HGMOLFCO_01494 7.1e-104 ypmS S Uncharacterized protein conserved in bacteria (DUF2140)
HGMOLFCO_01495 3.1e-36 yozE S Belongs to the UPF0346 family
HGMOLFCO_01496 8.4e-162 ylqF S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HGMOLFCO_01497 3.9e-139 rnhB 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HGMOLFCO_01498 3.6e-165 dprA LU DNA protecting protein DprA
HGMOLFCO_01499 0.0 topA 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HGMOLFCO_01500 2.6e-152 D DNA integration
HGMOLFCO_01501 5.3e-172 lacX 5.1.3.3 G Aldose 1-epimerase
HGMOLFCO_01502 1.1e-102 plsY 2.3.1.15, 3.5.1.104 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
HGMOLFCO_01503 0.0 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HGMOLFCO_01504 0.0 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HGMOLFCO_01505 5.2e-95 S Protein of unknown function (DUF1440)
HGMOLFCO_01506 7.3e-172 ppaC 3.6.1.1 C inorganic pyrophosphatase
HGMOLFCO_01507 2.3e-71 yqkB S Belongs to the HesB IscA family
HGMOLFCO_01508 3.4e-76 msrB 1.8.4.11, 1.8.4.12 O peptide methionine sulfoxide reductase
HGMOLFCO_01509 8.2e-93 ywnH 2.3.1.183 M Acetyltransferase (GNAT) domain
HGMOLFCO_01510 1.7e-81 yebR 1.8.4.14 T GAF domain-containing protein
HGMOLFCO_01511 4.7e-244 U Belongs to the purine-cytosine permease (2.A.39) family
HGMOLFCO_01512 8e-243 codA 3.5.4.1 F cytosine deaminase
HGMOLFCO_01513 0.0 oppD EP Psort location Cytoplasmic, score
HGMOLFCO_01515 1.8e-256 rarA L recombination factor protein RarA
HGMOLFCO_01516 4.7e-120 S Protein of unknown function (DUF554)
HGMOLFCO_01517 2.3e-243 yhjX P Major Facilitator Superfamily
HGMOLFCO_01519 2.5e-17 lmrB EGP Major facilitator Superfamily
HGMOLFCO_01520 2.6e-20 clcA P chloride
HGMOLFCO_01521 7.7e-30 clcA P chloride
HGMOLFCO_01522 1e-15
HGMOLFCO_01523 4.5e-191 gap 1.2.1.12 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
HGMOLFCO_01524 6.6e-226 pgk 2.7.2.3, 5.3.1.1 F Belongs to the phosphoglycerate kinase family
HGMOLFCO_01525 3.1e-144 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
HGMOLFCO_01526 1e-248 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
HGMOLFCO_01527 3.3e-253 yifK E Amino acid permease
HGMOLFCO_01528 2.2e-290 clcA P chloride
HGMOLFCO_01529 4.5e-33 secG U Preprotein translocase
HGMOLFCO_01530 0.0 rnr J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
HGMOLFCO_01531 2.9e-84 smpB J the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
HGMOLFCO_01532 5.5e-109 yxjI
HGMOLFCO_01533 2.8e-136 ung 3.2.2.27 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HGMOLFCO_01534 7.1e-178 pta 2.3.1.8, 3.6.3.21 C phosphate acetyltransferase
HGMOLFCO_01535 2.9e-81 ydiB 2.7.1.221, 5.1.1.1 O Hydrolase, P-loop family
HGMOLFCO_01536 7.3e-89 K Acetyltransferase (GNAT) domain
HGMOLFCO_01537 1.3e-101 dnaQ 2.7.7.7 L DNA polymerase III
HGMOLFCO_01538 5.7e-166 murB 1.3.1.98 M Cell wall formation
HGMOLFCO_01539 7.8e-149 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HGMOLFCO_01540 3.5e-115 ybbR S YbbR-like protein
HGMOLFCO_01541 3.2e-253 glmM 5.4.2.10 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HGMOLFCO_01542 0.0 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
HGMOLFCO_01543 3.3e-52
HGMOLFCO_01544 5.4e-211 oatA I Acyltransferase
HGMOLFCO_01545 4e-150 XK27_02985 S Sucrose-6F-phosphate phosphohydrolase
HGMOLFCO_01546 2.6e-69 lytE M Lysin motif
HGMOLFCO_01547 2.3e-158 MA20_14895 S Conserved hypothetical protein 698
HGMOLFCO_01548 9.6e-169 K LysR substrate binding domain
HGMOLFCO_01549 1.9e-130 manA 5.3.1.8 G mannose-6-phosphate isomerase
HGMOLFCO_01550 5.1e-148 yitS S EDD domain protein, DegV family
HGMOLFCO_01551 6.5e-90 racA K Domain of unknown function (DUF1836)
HGMOLFCO_01552 2.3e-181 yfeX P Peroxidase
HGMOLFCO_01553 5.3e-181 manL 2.7.1.191 G PTS system sorbose subfamily IIB component
HGMOLFCO_01554 3.5e-114 manY G PTS system
HGMOLFCO_01555 3e-170 manN G system, mannose fructose sorbose family IID component
HGMOLFCO_01556 1.6e-57 S Domain of unknown function (DUF956)
HGMOLFCO_01558 1.5e-133 L PFAM transposase, IS4 family protein
HGMOLFCO_01559 4.8e-131 K response regulator
HGMOLFCO_01560 1.3e-250 yclK 2.7.13.3 T Histidine kinase
HGMOLFCO_01561 5.9e-152 glcU U sugar transport
HGMOLFCO_01562 3.5e-216 xylR GK ROK family
HGMOLFCO_01563 2.1e-252 xylT EGP Major facilitator Superfamily
HGMOLFCO_01564 6.4e-270 xylA 5.3.1.5 G Belongs to the xylose isomerase family
HGMOLFCO_01565 1.8e-297 xylB 2.7.1.12, 2.7.1.17 G Xylulose kinase
HGMOLFCO_01566 2.3e-84 3.2.1.37 GH43 K helix_turn_helix, arabinose operon control protein
HGMOLFCO_01567 0.0 3.2.1.37 GH43 G Belongs to the glycosyl hydrolase 43 family
HGMOLFCO_01568 3.9e-221 G Major Facilitator
HGMOLFCO_01569 6.1e-105 ahpC 1.11.1.15 O Peroxiredoxin
HGMOLFCO_01570 0.0 trxB2 1.8.1.9 C Thioredoxin domain
HGMOLFCO_01571 9.7e-29 L Transposase
HGMOLFCO_01572 3.1e-124 S Membrane
HGMOLFCO_01573 3.2e-234 gltP U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
HGMOLFCO_01574 0.0 pepF E oligoendopeptidase F
HGMOLFCO_01575 5.1e-179 K helix_turn _helix lactose operon repressor
HGMOLFCO_01576 7.2e-141 IQ Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HGMOLFCO_01577 1.2e-233 V MatE
HGMOLFCO_01578 6.7e-69 def_1 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins
HGMOLFCO_01579 1e-141 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HGMOLFCO_01580 4.1e-46 acyP 3.6.1.7 C Belongs to the acylphosphatase family
HGMOLFCO_01581 1.2e-141 spoU 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HGMOLFCO_01582 7.8e-91 XK27_09705 6.1.1.14 S Metal dependent phosphohydrolases with conserved 'HD' motif.
HGMOLFCO_01583 7.8e-60 yodB K Transcriptional regulator, HxlR family
HGMOLFCO_01584 5.1e-198 pheS 6.1.1.20 J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HGMOLFCO_01585 0.0 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HGMOLFCO_01586 3e-116 udk 2.7.1.48 F Cytidine monophosphokinase
HGMOLFCO_01587 2.2e-79 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
HGMOLFCO_01588 0.0 S membrane
HGMOLFCO_01589 0.0 pbp2b 3.4.16.4 M Penicillin-binding Protein
HGMOLFCO_01590 3.2e-21 rpmG J Belongs to the bacterial ribosomal protein bL33 family
HGMOLFCO_01591 2.4e-98 ygfA 6.3.3.2 H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HGMOLFCO_01592 1.1e-116 gluP 3.4.21.105 S Peptidase, S54 family
HGMOLFCO_01593 9.6e-36 yqgQ S Bacterial protein of unknown function (DUF910)
HGMOLFCO_01594 3.7e-179 glk 2.7.1.2 G Glucokinase
HGMOLFCO_01595 1.5e-71 yqhL P Rhodanese-like protein
HGMOLFCO_01596 4.8e-24 WQ51_02665 S Protein of unknown function (DUF3042)
HGMOLFCO_01597 1.2e-171 miaA 2.5.1.75 F Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HGMOLFCO_01598 1.4e-261 glnA 6.3.1.2 E glutamine synthetase
HGMOLFCO_01599 4.7e-13
HGMOLFCO_01600 2.2e-149
HGMOLFCO_01601 3.9e-176
HGMOLFCO_01602 1.9e-92 dut S Protein conserved in bacteria
HGMOLFCO_01604 1.3e-114 K Transcriptional regulator
HGMOLFCO_01605 5.2e-50 rplU J This protein binds to 23S rRNA in the presence of protein L20
HGMOLFCO_01606 9e-53 ysxB J Cysteine protease Prp
HGMOLFCO_01607 7.1e-46 rpmA J Belongs to the bacterial ribosomal protein bL27 family
HGMOLFCO_01608 8.9e-206 pepP 3.4.11.9, 3.4.13.9 E Creatinase/Prolidase N-terminal domain
HGMOLFCO_01609 4.1e-72 yqhY S Asp23 family, cell envelope-related function
HGMOLFCO_01610 2e-68 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HGMOLFCO_01611 2.6e-160 folD 1.5.1.5, 3.5.4.9 F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HGMOLFCO_01612 2.3e-257 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HGMOLFCO_01613 1e-18 xseB 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HGMOLFCO_01614 2.1e-157 ispA 2.5.1.1, 2.5.1.10, 2.5.1.29, 2.5.1.90 H Belongs to the FPP GGPP synthase family
HGMOLFCO_01615 3.2e-147 rrmJ 2.1.1.226, 2.1.1.227 J Ribosomal RNA large subunit methyltransferase J
HGMOLFCO_01616 2.3e-75 argR K Regulates arginine biosynthesis genes
HGMOLFCO_01617 1.3e-307 recN L May be involved in recombinational repair of damaged DNA
HGMOLFCO_01618 2.5e-15
HGMOLFCO_01619 3.9e-113 gmk 2.7.4.8 F Essential for recycling GMP and indirectly, cGMP
HGMOLFCO_01620 9.4e-46 rpoZ 2.7.7.6 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
HGMOLFCO_01621 2.3e-221 coaBC 4.1.1.36, 6.3.2.5 H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HGMOLFCO_01622 0.0 priA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HGMOLFCO_01623 2.7e-174 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HGMOLFCO_01624 2e-247 sun 2.1.1.176 J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HGMOLFCO_01625 2.2e-131 stp 3.1.3.16 T phosphatase
HGMOLFCO_01626 0.0 KLT serine threonine protein kinase
HGMOLFCO_01627 4.1e-164 rsgA 3.1.3.100 S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
HGMOLFCO_01628 1.1e-118 rpe 5.1.3.1 G Belongs to the ribulose-phosphate 3-epimerase family
HGMOLFCO_01629 4e-124 thiN 2.7.6.2 H thiamine pyrophosphokinase
HGMOLFCO_01630 1.4e-26 rpmB J Belongs to the bacterial ribosomal protein bL28 family
HGMOLFCO_01631 3.6e-58 asp S Asp23 family, cell envelope-related function
HGMOLFCO_01632 5.8e-297 yloV S DAK2 domain fusion protein YloV
HGMOLFCO_01633 0.0 recG 3.6.4.12 L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HGMOLFCO_01634 3.1e-163 plsX 2.3.1.15 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
HGMOLFCO_01635 4.5e-36 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
HGMOLFCO_01636 4e-130 rnc 3.1.26.3 J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
HGMOLFCO_01637 0.0 smc D Required for chromosome condensation and partitioning
HGMOLFCO_01638 1.5e-198 ftsY U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HGMOLFCO_01639 3.7e-57 ylxM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HGMOLFCO_01640 7.6e-245 ffh 3.6.5.4 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HGMOLFCO_01642 4.3e-93
HGMOLFCO_01643 2.6e-129 K Transcriptional regulatory protein, C-terminal domain protein
HGMOLFCO_01644 5.1e-159 pstS P Phosphate
HGMOLFCO_01645 4.7e-152 pstC P probably responsible for the translocation of the substrate across the membrane
HGMOLFCO_01646 1.6e-152 pstA P Phosphate transport system permease protein PstA
HGMOLFCO_01647 6.8e-136 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
HGMOLFCO_01648 1.1e-122 phoU P Plays a role in the regulation of phosphate uptake
HGMOLFCO_01649 2.9e-44 rpsP J Belongs to the bacterial ribosomal protein bS16 family
HGMOLFCO_01650 5.4e-40 ylqC S Belongs to the UPF0109 family
HGMOLFCO_01651 2.1e-88 rimM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HGMOLFCO_01652 2.9e-142 trmD 2.1.1.228, 4.6.1.12 J Belongs to the RNA methyltransferase TrmD family
HGMOLFCO_01653 4.9e-260 yfnA E Amino Acid
HGMOLFCO_01654 1.3e-57 rplS J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
HGMOLFCO_01655 2.7e-291 cas3 L CRISPR-associated helicase cas3
HGMOLFCO_01656 5.9e-156 casA L the current gene model (or a revised gene model) may contain a frame shift
HGMOLFCO_01657 5.4e-40 casB S CRISPR-associated protein Cse2 (CRISPR_cse2)
HGMOLFCO_01658 9e-129 casC L CT1975-like protein
HGMOLFCO_01659 1.4e-66 casD S CRISPR-associated protein (Cas_Cas5)
HGMOLFCO_01660 2.6e-32 casE S CRISPR_assoc
HGMOLFCO_01661 3.2e-127 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HGMOLFCO_01662 1.4e-79 cas2 2.7.7.7 L CRISPR-associated protein (Cas_Cas2CT1978)
HGMOLFCO_01663 3.4e-17 lutA C Cysteine-rich domain
HGMOLFCO_01664 7.1e-217 mvaS 2.3.3.10 I Hydroxymethylglutaryl-CoA synthase
HGMOLFCO_01665 4.2e-115 lexA 3.4.21.88 K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HGMOLFCO_01666 2.4e-37 ynzC S UPF0291 protein
HGMOLFCO_01667 2.7e-27 yneF S Uncharacterised protein family (UPF0154)
HGMOLFCO_01668 2.1e-114 plsC 2.3.1.51 I Acyltransferase
HGMOLFCO_01669 8e-137 yabB 2.1.1.223 L Methyltransferase small domain
HGMOLFCO_01670 2.3e-47 yazA L GIY-YIG catalytic domain protein
HGMOLFCO_01671 5e-142 rpsB J Belongs to the universal ribosomal protein uS2 family
HGMOLFCO_01672 4.9e-154 tsf J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HGMOLFCO_01673 7e-130 pyrH 2.7.4.22 F Catalyzes the reversible phosphorylation of UMP to UDP
HGMOLFCO_01674 4.1e-93 frr J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
HGMOLFCO_01675 2.9e-142 uppS 2.5.1.31 H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HGMOLFCO_01676 2.3e-134 cdsA 2.7.7.41 I Belongs to the CDS family
HGMOLFCO_01677 1e-232 rseP 3.4.21.107, 3.4.21.116 M zinc metalloprotease
HGMOLFCO_01678 1.3e-11
HGMOLFCO_01679 2.7e-19
HGMOLFCO_01680 1.1e-197 S Psort location Cytoplasmic, score
HGMOLFCO_01681 3.9e-106 S RloB-like protein
HGMOLFCO_01682 3.8e-207 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
HGMOLFCO_01683 0.0 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
HGMOLFCO_01684 0.0 glyS 6.1.1.14 J Glycyl-tRNA synthetase beta subunit
HGMOLFCO_01685 4.9e-187 glyQ 6.1.1.14 J glycyl-tRNA synthetase alpha subunit
HGMOLFCO_01686 3.2e-155 recO L Involved in DNA repair and RecF pathway recombination
HGMOLFCO_01687 8.7e-170 era S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HGMOLFCO_01688 3.9e-66 dgkA 2.7.1.107, 2.7.1.66 M Diacylglycerol kinase
HGMOLFCO_01689 2.5e-80 ybeY 2.6.99.2, 3.5.4.5 S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HGMOLFCO_01690 1.1e-178 phoH T phosphate starvation-inducible protein PhoH
HGMOLFCO_01691 4.6e-71 yqeY S YqeY-like protein
HGMOLFCO_01692 5.7e-23 rpsU J Belongs to the bacterial ribosomal protein bS21 family
HGMOLFCO_01693 5.1e-130 yfeJ 6.3.5.2 F glutamine amidotransferase
HGMOLFCO_01694 0.0 aspS 6.1.1.12 J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
HGMOLFCO_01695 1e-248 hisS 6.1.1.21 J histidyl-tRNA synthetase
HGMOLFCO_01696 1e-195 6.3.1.20 H Lipoate-protein ligase
HGMOLFCO_01697 1.6e-174 lytH 3.5.1.28 M Ami_3
HGMOLFCO_01698 1.4e-169 yniA G Phosphotransferase enzyme family
HGMOLFCO_01699 5e-173 mmuM 1.5.1.20, 2.1.1.10 H homocysteine S-methyltransferase
HGMOLFCO_01700 1.4e-246 mmuP E amino acid
HGMOLFCO_01701 2.3e-83 lacR K Transcriptional regulator
HGMOLFCO_01702 4.1e-217 lacS G Transporter

eggNOG-mapper v2 (Database: eggNOG v5.0, Jul. 2018 release)