ORF_ID e_value Gene_name EC_number CAZy COGs Description
HKFIFLAF_00001 5.8e-300 miaB 2.8.4.3 J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HKFIFLAF_00002 2.1e-49 ymcA 3.6.3.21 S Belongs to the UPF0342 family
HKFIFLAF_00003 6.2e-99 cotE S Outer spore coat protein E (CotE)
HKFIFLAF_00004 0.0 mutS L that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HKFIFLAF_00005 0.0 mutL L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HKFIFLAF_00006 1.3e-21 2.1.1.80, 3.1.1.61 S protein secretion by the type IV secretion system
HKFIFLAF_00009 8.1e-188 miaA 2.5.1.75 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HKFIFLAF_00010 1.2e-35 hfq J RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs
HKFIFLAF_00011 7.1e-175 spoVK O stage V sporulation protein K
HKFIFLAF_00012 2.1e-227 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HKFIFLAF_00013 7.2e-247 ynbB 4.4.1.1 P COG4100 Cystathionine beta-lyase family protein involved in aluminum resistance
HKFIFLAF_00014 4.6e-171 polA 2.7.7.7 L 5'3' exonuclease
HKFIFLAF_00015 3.6e-27 ypeQ S Zinc-finger
HKFIFLAF_00017 1.2e-31 cspD K Cold-shock protein
HKFIFLAF_00018 6e-73 mntR K Involved in manganese homeostasis. Might activate the transcription of the mntABCD operon
HKFIFLAF_00019 0.0 fhs 6.3.4.3 F Belongs to the formate--tetrahydrofolate ligase family
HKFIFLAF_00020 2.6e-83
HKFIFLAF_00021 0.0 yfmR S COG0488 ATPase components of ABC transporters with duplicated ATPase domains
HKFIFLAF_00022 1.1e-153 ypgR C COG0694 Thioredoxin-like proteins and domains
HKFIFLAF_00023 2.3e-75 yphP S Belongs to the UPF0403 family
HKFIFLAF_00024 3.3e-106 ypjP S YpjP-like protein
HKFIFLAF_00025 4.8e-156 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HKFIFLAF_00026 1.8e-92 folA 1.1.1.262, 1.5.1.3 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HKFIFLAF_00027 1.4e-110 hlyIII S protein, Hemolysin III
HKFIFLAF_00028 2.3e-139 ypmR E COG2755 Lysophospholipase L1 and related esterases
HKFIFLAF_00029 2.3e-96 ypmS S protein conserved in bacteria
HKFIFLAF_00030 8.8e-275 rsmF 2.1.1.176, 2.1.1.178 J RNA-binding PUA-like domain of methyltransferase RsmF
HKFIFLAF_00031 1.6e-99 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HKFIFLAF_00032 1.6e-78 msrB 1.8.4.11, 1.8.4.12 O peptide methionine sulfoxide reductase
HKFIFLAF_00033 6.9e-08 S Protein of unknown function (Tiny_TM_bacill)
HKFIFLAF_00034 6.5e-193 NT CHASE3 domain
HKFIFLAF_00035 6.3e-34 yozE S Belongs to the UPF0346 family
HKFIFLAF_00036 5.1e-116 yodN
HKFIFLAF_00037 7.5e-25 yozD S YozD-like protein
HKFIFLAF_00038 1.8e-142 vanY 3.4.17.14 M D-alanyl-D-alanine carboxypeptidase
HKFIFLAF_00039 6e-277 ctpA 3.4.21.102 M Belongs to the peptidase S41A family
HKFIFLAF_00040 8.7e-67 ypoP K transcriptional
HKFIFLAF_00042 3.8e-99 ykwD J protein with SCP PR1 domains
HKFIFLAF_00043 2.3e-243 norM V Multidrug efflux pump
HKFIFLAF_00045 2.9e-187 dapF 5.1.1.7 E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HKFIFLAF_00046 0.0 ligD 6.5.1.1 L ATP-dependent DNA ligase
HKFIFLAF_00047 5e-132 ku L With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HKFIFLAF_00048 3.5e-99 3.6.1.27 I COG0671 Membrane-associated phospholipid phosphatase
HKFIFLAF_00050 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
HKFIFLAF_00051 0.0 yyaL O COG1331 Highly conserved protein containing a thioredoxin domain
HKFIFLAF_00052 8e-222 ymfD EGP Major facilitator Superfamily
HKFIFLAF_00053 1.3e-122 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HKFIFLAF_00054 1.6e-250 arlS 2.7.13.3 T Histidine kinase
HKFIFLAF_00055 1.5e-74 yozR S COG0071 Molecular chaperone (small heat shock protein)
HKFIFLAF_00056 0.0 sucA 1.2.4.2, 4.1.1.71 C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)
HKFIFLAF_00057 8.9e-205 sucB 2.3.1.61 C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)
HKFIFLAF_00058 1.7e-287 dhaS 1.2.1.3, 1.2.1.39 C Belongs to the aldehyde dehydrogenase family
HKFIFLAF_00059 3.8e-83 rok S Repressor of ComK
HKFIFLAF_00060 2.5e-117 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HKFIFLAF_00062 3.2e-161 yqfU S Uncharacterized protein conserved in bacteria (DUF2179)
HKFIFLAF_00063 0.0 topB 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HKFIFLAF_00064 7.8e-193 yceA S Belongs to the UPF0176 family
HKFIFLAF_00065 5.7e-126 yoqW S Belongs to the SOS response-associated peptidase family
HKFIFLAF_00066 1.8e-104 thiT S Proton-coupled thiamine transporter YuaJ
HKFIFLAF_00067 4.2e-166 yflN S COG0491 Zn-dependent hydrolases, including glyoxylases
HKFIFLAF_00068 6.1e-79 S Domain in cystathionine beta-synthase and other proteins.
HKFIFLAF_00069 3.1e-121 yhfW CE COG0665 Glycine D-amino acid oxidases (deaminating)
HKFIFLAF_00070 9.1e-107 yocH CBM50 M COG1388 FOG LysM repeat
HKFIFLAF_00071 0.0 topB2 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HKFIFLAF_00072 4.1e-34 ycgH E COG1113 Gamma-aminobutyrate permease and related permeases
HKFIFLAF_00073 8.1e-194 ycgH E COG1113 Gamma-aminobutyrate permease and related permeases
HKFIFLAF_00074 1.2e-177 corA P Mg2 transporter protein
HKFIFLAF_00075 3.3e-69 S CHY zinc finger
HKFIFLAF_00076 3.8e-215 hisZ 2.4.2.17, 6.1.1.21 E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HKFIFLAF_00077 1.3e-108 hisG 2.4.2.17 E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
HKFIFLAF_00078 3.3e-231 hisD 1.1.1.23, 1.1.1.308 E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HKFIFLAF_00079 5.8e-106 hisB 1.1.1.23, 2.6.1.9, 3.1.3.15, 4.2.1.19 E imidazoleglycerol-phosphate dehydratase
HKFIFLAF_00080 2.1e-111 hisH E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HKFIFLAF_00081 9.2e-127 hisA 5.3.1.16 E 1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HKFIFLAF_00082 1.3e-134 hisF 3.5.4.19, 3.6.1.31 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
HKFIFLAF_00083 3.9e-119 hisE 3.5.4.19, 3.5.4.25, 3.6.1.31, 5.3.1.16 E belongs to the PRA-CH family
HKFIFLAF_00084 5.9e-41 yedF O Belongs to the sulfur carrier protein TusA family
HKFIFLAF_00085 6.3e-240 yedE S Sulphur transport
HKFIFLAF_00086 2.2e-171 rarD S -transporter
HKFIFLAF_00087 1e-219 ktrB P COG0168 Trk-type K transport systems, membrane components
HKFIFLAF_00088 1.9e-121 P COG0569 K transport systems, NAD-binding component
HKFIFLAF_00089 3e-136 ykrK S Domain of unknown function (DUF1836)
HKFIFLAF_00090 1e-17
HKFIFLAF_00091 3.6e-48 yxcD S Protein of unknown function (DUF2653)
HKFIFLAF_00092 8.6e-218 yeaN P COG2807 Cyanate permease
HKFIFLAF_00093 0.0 ubiB S ABC1 family
HKFIFLAF_00094 4.7e-24 S ATP synthase, subunit b
HKFIFLAF_00095 2.1e-99 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HKFIFLAF_00097 2.7e-31 cspB K Cold shock
HKFIFLAF_00098 6.3e-25 S Protein of unknown function (DUF3813)
HKFIFLAF_00099 3.6e-32 yitU 3.1.3.104 S hydrolases of the HAD superfamily
HKFIFLAF_00100 1.3e-104 yitU 3.1.3.104 S hydrolases of the HAD superfamily
HKFIFLAF_00101 9.5e-52 yitW S metal-sulfur cluster biosynthetic enzyme
HKFIFLAF_00102 4.4e-25 yjzC S YjzC-like protein
HKFIFLAF_00103 0.0 clpB O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
HKFIFLAF_00105 1e-147 5.1.3.2 GM ADP-glyceromanno-heptose 6-epimerase activity
HKFIFLAF_00107 3.3e-172 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HKFIFLAF_00108 8.9e-234 fabF 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
HKFIFLAF_00109 2.7e-151 yjaZ O Zn-dependent protease
HKFIFLAF_00110 1.9e-189 oppD P Belongs to the ABC transporter superfamily
HKFIFLAF_00111 1.3e-176 oppF P Belongs to the ABC transporter superfamily
HKFIFLAF_00112 1.3e-166 oppB P COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
HKFIFLAF_00113 3.4e-134 oppC EP binding-protein-dependent transport systems inner membrane component
HKFIFLAF_00114 0.0 oppA1 E COG0747 ABC-type dipeptide transport system, periplasmic component
HKFIFLAF_00115 2.3e-147 yjbA S Belongs to the UPF0736 family
HKFIFLAF_00116 1e-184 trpS 6.1.1.2 J Tryptophanyl-tRNA synthetase
HKFIFLAF_00117 2.4e-48 S Domain of unknown function (DUF3899)
HKFIFLAF_00118 1.2e-297 dppE_1 E ABC transporter substrate-binding protein
HKFIFLAF_00119 5.4e-143 oppB P COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
HKFIFLAF_00120 5.5e-181 oppC EP COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
HKFIFLAF_00121 3.7e-196 oppD P Belongs to the ABC transporter superfamily
HKFIFLAF_00122 4.3e-172 oppF E Belongs to the ABC transporter superfamily
HKFIFLAF_00123 1.6e-67 spxA 1.20.4.1 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
HKFIFLAF_00124 2.7e-120 mecA NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC
HKFIFLAF_00125 6.1e-227 yjbF S Competence protein
HKFIFLAF_00126 0.0 pepF E oligoendopeptidase F
HKFIFLAF_00128 9.1e-161 yjbH Q dithiol-disulfide isomerase involved in polyketide biosynthesis
HKFIFLAF_00129 1.4e-74 yjbI S COG2346 Truncated hemoglobins
HKFIFLAF_00130 1.1e-96 yjbJ M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)
HKFIFLAF_00131 7.2e-101 yjbK S protein conserved in bacteria
HKFIFLAF_00132 5.8e-67 yjbL S Belongs to the UPF0738 family
HKFIFLAF_00133 3.8e-122 yjbM 2.7.6.5 S GTP pyrophosphokinase
HKFIFLAF_00134 4.9e-153 nadK 2.7.1.23 G Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HKFIFLAF_00135 5.8e-163 yjbO 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
HKFIFLAF_00136 9e-138 prpE 3.6.1.41 T Asymmetrically hydrolyzes Ap4p to yield AMP and ATP
HKFIFLAF_00137 1.2e-140 fabI 1.3.1.10, 1.3.1.9 I Enoyl- acyl-carrier-protein reductase NADH
HKFIFLAF_00140 1.5e-82 cotY S Spore coat protein
HKFIFLAF_00141 8.4e-60 S Protein of unknown function (DUF1360)
HKFIFLAF_00143 7.3e-80 S Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
HKFIFLAF_00144 2.5e-83 spoVAC S stage V sporulation protein AC
HKFIFLAF_00145 8.4e-190 spoVAD I Stage V sporulation protein AD
HKFIFLAF_00146 1.1e-56 spoVAE S stage V sporulation protein
HKFIFLAF_00148 4.5e-39 spoVIF S Stage VI sporulation protein F
HKFIFLAF_00150 4.2e-74 yjcF S COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HKFIFLAF_00151 6.3e-93 yjcG J Belongs to the 2H phosphoesterase superfamily. YjcG family
HKFIFLAF_00152 1.7e-136 yjcH P COG2382 Enterochelin esterase and related enzymes
HKFIFLAF_00159 2e-33 ydhM 2.7.1.196, 2.7.1.205 G PTS system, Lactose/Cellobiose specific IIB subunit
HKFIFLAF_00160 3e-208 celB G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HKFIFLAF_00161 4.4e-36 celC 2.7.1.196, 2.7.1.205 G phosphotransferase system
HKFIFLAF_00162 3.8e-241 ydhP 3.2.1.21, 3.2.1.86 GT1 G Glycosyl hydrolase family 1
HKFIFLAF_00163 1.7e-91 ydhQ K UTRA
HKFIFLAF_00164 1.7e-159 gmuE 2.7.1.2, 2.7.1.4 GK COG1940 Transcriptional regulator sugar kinase
HKFIFLAF_00165 9.5e-09 S PD-(D/E)XK nuclease family transposase
HKFIFLAF_00166 8.7e-129 IQ Enoyl-(Acyl carrier protein) reductase
HKFIFLAF_00167 3.4e-166 yhaQ S ABC transporter, ATP-binding protein
HKFIFLAF_00168 4.1e-210 yhaP CP COG1668 ABC-type Na efflux pump, permease component
HKFIFLAF_00169 2.4e-261 pepC 3.4.22.40 E Papain family cysteine protease
HKFIFLAF_00170 8.7e-221 EGP Major facilitator Superfamily
HKFIFLAF_00171 0.0 pepF2 E COG1164 Oligoendopeptidase F
HKFIFLAF_00172 2.4e-12 sidE D nuclear chromosome segregation
HKFIFLAF_00173 5.7e-36 ykuS S Belongs to the UPF0180 family
HKFIFLAF_00174 2.1e-25
HKFIFLAF_00176 0.0 6.2.1.1, 6.2.1.16 I AMP-dependent synthetase
HKFIFLAF_00177 1.3e-93 ywrA P COG2059 Chromate transport protein ChrA
HKFIFLAF_00178 3.9e-102 chrA P Chromate transporter
HKFIFLAF_00179 1.2e-82 ywrC K Transcriptional regulator
HKFIFLAF_00180 1.4e-37 L Belongs to the 'phage' integrase family
HKFIFLAF_00182 1.7e-146 pocR K Sensory domain found in PocR
HKFIFLAF_00183 1.8e-223 ackA 2.7.2.1, 2.7.2.15 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HKFIFLAF_00184 1.6e-182 yxjG 2.1.1.14 E Methionine synthase
HKFIFLAF_00185 3.3e-49 esxA S Belongs to the WXG100 family
HKFIFLAF_00186 0.0 esaA S domain protein
HKFIFLAF_00187 1.7e-07 S WXG100 protein secretion system (Wss), protein EssA
HKFIFLAF_00188 9.5e-42 yukD S WXG100 protein secretion system (Wss), protein YukD
HKFIFLAF_00189 5e-222 essB S WXG100 protein secretion system (Wss), protein YukC
HKFIFLAF_00190 0.0 essC D COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins
HKFIFLAF_00191 4.6e-09 S Domain of unknown function (DUF5082)
HKFIFLAF_00192 5.3e-44
HKFIFLAF_00193 1.2e-168 yjdA S LXG domain of WXG superfamily
HKFIFLAF_00194 1.5e-106
HKFIFLAF_00195 5.4e-75 ctsR K Belongs to the CtsR family
HKFIFLAF_00196 1.3e-99 mcsA 2.7.14.1 S protein with conserved CXXC pairs
HKFIFLAF_00197 2.8e-191 mcsB 2.7.14.1, 2.7.3.2, 2.7.3.3 E Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity
HKFIFLAF_00198 0.0 clpC O Belongs to the ClpA ClpB family
HKFIFLAF_00199 1.1e-253 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HKFIFLAF_00200 7.6e-197 yacL S COG4956 Integral membrane protein (PIN domain superfamily)
HKFIFLAF_00201 7.5e-118 ispD 2.7.7.60, 4.6.1.12 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)
HKFIFLAF_00202 2.1e-82 ispF 2.1.1.228, 2.7.7.60, 4.6.1.12 I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)
HKFIFLAF_00203 3.2e-283 gltX 6.1.1.17, 6.1.1.24 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HKFIFLAF_00204 4.2e-113 cysE 2.3.1.30 E Serine acetyltransferase
HKFIFLAF_00205 6.4e-273 cysS 6.1.1.16, 6.3.1.13 J Belongs to the class-I aminoacyl-tRNA synthetase family
HKFIFLAF_00206 3e-69 mrnC J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HKFIFLAF_00207 1.3e-134 trmH 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HKFIFLAF_00208 8.7e-90 yacP S RNA-binding protein containing a PIN domain
HKFIFLAF_00209 7.2e-110 sigH K Belongs to the sigma-70 factor family
HKFIFLAF_00210 6.6e-24 secE U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
HKFIFLAF_00211 3.2e-95 nusG K Participates in transcription elongation, termination and antitermination
HKFIFLAF_00212 1.4e-69 rplK J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HKFIFLAF_00213 1.3e-125 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
HKFIFLAF_00214 1e-08 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
HKFIFLAF_00215 5.4e-81 rplJ J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HKFIFLAF_00216 3e-52 rplL J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
HKFIFLAF_00217 2.5e-112 rsmC 2.1.1.172 J Methyltransferase
HKFIFLAF_00218 0.0 rpoB 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HKFIFLAF_00219 0.0 rpoC 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HKFIFLAF_00220 1.2e-36 rplGB J Belongs to the eukaryotic ribosomal protein eL8 family
HKFIFLAF_00221 3.3e-71 rpsL J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HKFIFLAF_00222 2.1e-82 rpsG J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
HKFIFLAF_00223 0.0 fusA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HKFIFLAF_00224 1.8e-223 tuf J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HKFIFLAF_00225 3.4e-49 rpsJ J Involved in the binding of tRNA to the ribosomes
HKFIFLAF_00226 2.6e-112 rplC J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HKFIFLAF_00227 1.6e-106 rplD J Forms part of the polypeptide exit tunnel
HKFIFLAF_00228 1.8e-41 rplW J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
HKFIFLAF_00229 1.5e-155 rplB J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HKFIFLAF_00230 2.2e-47 rpsS J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HKFIFLAF_00231 6.6e-54 rplV J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HKFIFLAF_00232 2.3e-116 rpsC J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HKFIFLAF_00233 9.2e-77 rplP J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HKFIFLAF_00234 2.7e-26 rpmC J Belongs to the universal ribosomal protein uL29 family
HKFIFLAF_00235 6e-39 rpsQ J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HKFIFLAF_00236 1.5e-59 rplN J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HKFIFLAF_00237 9.6e-52 rplX J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HKFIFLAF_00238 1.6e-94 rplE J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HKFIFLAF_00239 5.8e-28 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HKFIFLAF_00240 1e-66 rpsH J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HKFIFLAF_00241 1e-93 rplF J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HKFIFLAF_00242 3e-57 rplR J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HKFIFLAF_00243 6.2e-85 rpsE J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HKFIFLAF_00244 4.1e-23 rpmD J Ribosomal protein L30
HKFIFLAF_00245 1.2e-71 rplO J binds to the 23S rRNA
HKFIFLAF_00246 1.5e-228 secY U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
HKFIFLAF_00247 9.7e-123 adk 2.7.4.3 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
HKFIFLAF_00248 2.4e-33 infA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HKFIFLAF_00249 1.8e-57 rpsM J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HKFIFLAF_00250 5.2e-63 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HKFIFLAF_00251 5.8e-169 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HKFIFLAF_00252 5.8e-65 rplQ J Ribosomal protein L17
HKFIFLAF_00253 4.1e-157 cbiO P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HKFIFLAF_00254 1.1e-161 ecfA2 3.6.3.55 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HKFIFLAF_00255 1.7e-137 ecfT P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HKFIFLAF_00256 4.6e-137 truA 5.4.99.12 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
HKFIFLAF_00257 3.8e-78 rplM J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HKFIFLAF_00258 1.6e-64 rpsI J Belongs to the universal ribosomal protein uS9 family
HKFIFLAF_00259 3.3e-09 S Protein conserved in bacteria
HKFIFLAF_00261 1.1e-225 sat 2.7.7.4 P Belongs to the sulfate adenylyltransferase family
HKFIFLAF_00262 2.5e-112 cysC 2.7.1.25, 2.7.7.4 P Catalyzes the synthesis of activated sulfate
HKFIFLAF_00263 3.6e-274 lysP E amino acid
HKFIFLAF_00264 2.5e-82 ybaK S Protein of unknown function (DUF2521)
HKFIFLAF_00265 2.4e-130 cwlD 3.5.1.28 M n-acetylmuramoyl-L-alanine amidase
HKFIFLAF_00266 1.6e-196 mrp D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP
HKFIFLAF_00268 1.4e-61 gerD S Spore gernimation protein
HKFIFLAF_00269 1.6e-101 kbaA 2.7.8.43 S Involved in the activation of the KinB signaling pathway of sporulation
HKFIFLAF_00270 1.4e-211 S Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase
HKFIFLAF_00271 5.8e-174 K Transcriptional regulator
HKFIFLAF_00272 2.7e-137 pdaB 3.5.1.104 G xylanase chitin deacetylase
HKFIFLAF_00273 1.2e-30
HKFIFLAF_00274 1.9e-261 cydA 1.10.3.14 C oxidase, subunit
HKFIFLAF_00275 1.9e-181 cydB 1.10.3.14 C Cytochrome d ubiquinol oxidase, subunit II
HKFIFLAF_00276 0.0 cydD V ATP-binding
HKFIFLAF_00277 0.0 cydD V ATP-binding protein
HKFIFLAF_00278 3.3e-26
HKFIFLAF_00279 1.1e-192 ysxE S A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HKFIFLAF_00280 1.2e-198 spoVID M stage VI sporulation protein D
HKFIFLAF_00281 3.5e-249 hemL 5.4.3.8 H Glutamate-1-semialdehyde aminotransferase
HKFIFLAF_00282 7.1e-186 hemB 4.2.1.24 H Belongs to the ALAD family
HKFIFLAF_00283 1.5e-146 hemD 2.1.1.107, 4.2.1.75 H Uroporphyrinogen-III synthase
HKFIFLAF_00284 2.7e-166 hemC 2.1.1.107, 2.5.1.61, 4.2.1.75 H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
HKFIFLAF_00285 3.8e-148 hemX O cytochrome C
HKFIFLAF_00286 1.6e-241 hemA 1.2.1.70 H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HKFIFLAF_00287 4.5e-88 ysxD
HKFIFLAF_00288 4.4e-106 engB D Necessary for normal cell division and for the maintenance of normal septation
HKFIFLAF_00289 0.0 lon 3.4.21.53 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HKFIFLAF_00290 7.2e-308 lonB 3.4.21.53 LO Belongs to the peptidase S16 family
HKFIFLAF_00291 6.3e-235 clpX O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HKFIFLAF_00292 8.4e-211 tig D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
HKFIFLAF_00293 5.7e-183 trxA2 O COG0457 FOG TPR repeat
HKFIFLAF_00294 5.3e-72 S Protein of unknown function (DUF2512)
HKFIFLAF_00295 2.8e-45
HKFIFLAF_00297 2.8e-93 ysnB S Phosphoesterase
HKFIFLAF_00298 5.9e-106 rdgB 3.6.1.66 F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HKFIFLAF_00299 1.3e-190 gerM S COG5401 Spore germination protein
HKFIFLAF_00300 5.4e-71 adhB 1.1.1.1, 1.1.1.14, 1.1.1.284 E COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
HKFIFLAF_00301 1e-60 yraF M Spore coat protein
HKFIFLAF_00302 8.4e-31 yraG S Spore Coat Protein
HKFIFLAF_00303 6.2e-151 murI 3.6.1.66, 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
HKFIFLAF_00304 3.9e-78 ysmB 2.4.2.28 K transcriptional
HKFIFLAF_00305 4.2e-84 S GDYXXLXY protein
HKFIFLAF_00306 1.4e-185 S Predicted membrane protein (DUF2157)
HKFIFLAF_00308 2.3e-31 gerE K Transcriptional regulator
HKFIFLAF_00309 9.7e-88 ysmA S thioesterase
HKFIFLAF_00310 1.9e-149 sdhB 1.3.5.1, 1.3.5.4 C succinate dehydrogenase
HKFIFLAF_00311 0.0 sdhA 1.3.5.1, 1.3.5.4 C succinate dehydrogenase
HKFIFLAF_00312 5e-105 sdhC C succinate dehydrogenase
HKFIFLAF_00313 1.6e-79 yslB S Protein of unknown function (DUF2507)
HKFIFLAF_00314 1.6e-222 lysC 1.1.1.3, 2.7.2.4 E Belongs to the aspartokinase family
HKFIFLAF_00315 0.0 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
HKFIFLAF_00316 1.5e-52 trxA O Belongs to the thioredoxin family
HKFIFLAF_00317 1.1e-175 etfA C Electron transfer flavoprotein
HKFIFLAF_00318 2.4e-128 etfB C Electron transfer flavoprotein
HKFIFLAF_00319 6.3e-137 fadB 4.2.1.17 I Belongs to the enoyl-CoA hydratase isomerase family
HKFIFLAF_00320 1.6e-103 fadR K Transcriptional regulator
HKFIFLAF_00321 0.0 lcfA 6.2.1.3 IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
HKFIFLAF_00322 0.0 mutS2 L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
HKFIFLAF_00323 0.0 polX L COG1796 DNA polymerase IV (family X)
HKFIFLAF_00324 1.1e-87 cvpA S membrane protein, required for colicin V production
HKFIFLAF_00325 7.3e-46 zapA D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HKFIFLAF_00326 2.6e-169 rnhC 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HKFIFLAF_00327 2.3e-170 S Nuclease-related domain
HKFIFLAF_00328 0.0 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HKFIFLAF_00329 1.6e-180 pheS 6.1.1.20 J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HKFIFLAF_00331 3.1e-136 spoU 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HKFIFLAF_00332 7.5e-32 sspI S Belongs to the SspI family
HKFIFLAF_00333 2.6e-135
HKFIFLAF_00334 1.6e-29 sidE D nuclear chromosome segregation
HKFIFLAF_00335 1.3e-120 M1-1017 S Protein of unknown function (DUF1129)
HKFIFLAF_00336 1.8e-56 K Transcriptional regulator
HKFIFLAF_00337 2.3e-11 S NADPH-dependent FMN reductase
HKFIFLAF_00338 2.5e-126 queC 6.3.4.20 F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HKFIFLAF_00339 1.2e-174 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HKFIFLAF_00340 1.1e-101 yieF S NAD(P)H-dependent FMN reductase
HKFIFLAF_00341 7.3e-97 ypdE 4.4.1.5 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HKFIFLAF_00342 3.3e-80 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
HKFIFLAF_00344 3.3e-56 rplT J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HKFIFLAF_00345 4.4e-26 rpmI J Belongs to the bacterial ribosomal protein bL35 family
HKFIFLAF_00346 1.8e-108 infC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HKFIFLAF_00347 2.2e-219 G Transmembrane secretion effector
HKFIFLAF_00348 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HKFIFLAF_00349 4.3e-209 nupG F Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HKFIFLAF_00350 4.9e-128 deoD 2.4.2.1, 2.4.2.28 F Purine nucleoside phosphorylase
HKFIFLAF_00351 3e-173 deoR K COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain
HKFIFLAF_00352 1.1e-233 deoB 5.4.2.7 G Phosphotransfer between the C1 and C5 carbon atoms of pentose
HKFIFLAF_00353 4.2e-234 pdp 2.4.2.2, 2.4.2.4 F phosphorylase
HKFIFLAF_00354 1.7e-111 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HKFIFLAF_00355 4e-71 cdd 2.4.2.2, 3.5.4.5 F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
HKFIFLAF_00356 0.0 metE 2.1.1.14 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HKFIFLAF_00357 5.8e-85 S SMI1-KNR4 cell-wall
HKFIFLAF_00358 5e-187 guaC 1.1.1.205, 1.7.1.7 F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
HKFIFLAF_00359 6.3e-166 P ABC transporter substrate-binding protein
HKFIFLAF_00360 7.7e-216 ssuD 1.14.14.5 C Catalyzes the desulfonation of aliphatic sulfonates
HKFIFLAF_00361 4.4e-135 ssuC P COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component
HKFIFLAF_00362 2.5e-138 ssuB P Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import. Responsible for energy coupling to the transport system
HKFIFLAF_00363 3.5e-94 ssuE 1.5.1.38 S FMN reductase
HKFIFLAF_00364 7e-23 S Uncharacterized small protein (DUF2292)
HKFIFLAF_00365 3.5e-304 yhcX K Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
HKFIFLAF_00366 2.1e-80 XK27_04815 S Membrane transport protein
HKFIFLAF_00368 1.5e-30 S Domain of unknown function (DUF202)
HKFIFLAF_00369 4.6e-104 P Integral membrane protein TerC family
HKFIFLAF_00371 1.3e-92 cwlS 3.5.1.28 CBM50 M COG1388 FOG LysM repeat
HKFIFLAF_00372 2.5e-80 K helix_turn_helix multiple antibiotic resistance protein
HKFIFLAF_00373 0.0 yfiB V ABC transporter
HKFIFLAF_00374 0.0 yfiC V COG1132 ABC-type multidrug transport system, ATPase and permease components
HKFIFLAF_00375 4.1e-234 ybbC 3.2.1.52 S protein conserved in bacteria
HKFIFLAF_00376 0.0 ampC V Belongs to the UPF0214 family
HKFIFLAF_00377 0.0 nagA 3.2.1.52 G Belongs to the glycosyl hydrolase 3 family
HKFIFLAF_00378 6.7e-179 ydcZ S Putative inner membrane exporter, YdcZ
HKFIFLAF_00379 2.5e-29 cspL K Cold shock
HKFIFLAF_00380 8.3e-134 cpmA S AIR carboxylase
HKFIFLAF_00381 5.7e-136 larC 4.99.1.12 S Protein of unknown function DUF111
HKFIFLAF_00382 9e-86 larC 4.99.1.12 S Protein of unknown function DUF111
HKFIFLAF_00384 1.1e-234 yjhF EG COG2610 H gluconate symporter and related permeases
HKFIFLAF_00385 2e-149 S NAD synthase
HKFIFLAF_00386 0.0 K Propionate catabolism activator
HKFIFLAF_00387 5.4e-245 2.7.1.219, 2.7.1.220 S Putative nucleotide-binding of sugar-metabolising enzyme
HKFIFLAF_00388 4.4e-191 pdxA 1.1.1.262, 1.1.1.408, 1.1.1.409 H Belongs to the PdxA family
HKFIFLAF_00389 5.8e-233 C Domain of unknown function (DUF2088)
HKFIFLAF_00390 1.5e-118 ureH S PFAM Nickel cobalt transporter, high-affinity
HKFIFLAF_00391 3.9e-218 2.3.1.179 IQ Beta-ketoacyl synthase, C-terminal domain
HKFIFLAF_00392 1.6e-233 2.7.13.3 T His Kinase A (phosphoacceptor) domain
HKFIFLAF_00393 3.5e-09 2.7.13.3 T His Kinase A (phosphoacceptor) domain
HKFIFLAF_00394 1.7e-51
HKFIFLAF_00395 3e-257 G PTS system sugar-specific permease component
HKFIFLAF_00396 4.9e-182 rbsR K transcriptional
HKFIFLAF_00397 1.1e-121 5.1.3.1 G Ribulose-phosphate 3 epimerase family
HKFIFLAF_00398 4.7e-163 rbsK 2.7.1.15 H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKFIFLAF_00399 1.1e-290 ycnJ P protein, homolog of Cu resistance protein CopC
HKFIFLAF_00400 2e-101 ycnI S Domain of unkown function (DUF1775)
HKFIFLAF_00402 5.5e-143 S transposase or invertase
HKFIFLAF_00404 1.3e-23 ymbI L Transposase
HKFIFLAF_00405 1.8e-96 S HTH-like domain
HKFIFLAF_00406 2.9e-226 mtnE 2.6.1.83 E Aminotransferase
HKFIFLAF_00407 9.8e-146 mtnU 3.5.1.3 S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
HKFIFLAF_00408 1.2e-106 rsbX 3.1.3.16, 3.1.3.3 KT Sigma factor PP2C-like phosphatases
HKFIFLAF_00409 3.7e-137 sigB K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HKFIFLAF_00410 3.3e-80 rsbW 2.7.11.1 T Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B)
HKFIFLAF_00411 2.7e-52 rsbV T Belongs to the anti-sigma-factor antagonist family
HKFIFLAF_00412 5.6e-186 rsbU 3.1.3.3 KT phosphatase
HKFIFLAF_00413 2.9e-69 rsbT 2.7.11.1 T COG2172 Anti-sigma regulatory factor (Ser Thr protein kinase)
HKFIFLAF_00414 8.1e-55 rsbS T antagonist
HKFIFLAF_00415 7.4e-152 rsbR T Positive regulator of sigma-B
HKFIFLAF_00416 7.2e-56 ndoA L Toxic component of a toxin-antitoxin (TA) module
HKFIFLAF_00417 2e-40 ndoAI K transcriptional regulators containing the CopG Arc MetJ DNA-binding domain and a metal-binding domain
HKFIFLAF_00418 2.7e-216 alr 5.1.1.1, 5.1.1.5 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HKFIFLAF_00419 3e-187 ydcC M COG2834 Outer membrane lipoprotein-sorting protein
HKFIFLAF_00420 9.4e-56 acpS 2.7.6.3, 2.7.8.7, 5.1.1.1 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
HKFIFLAF_00421 4.6e-103 ydcA 3.4.21.105 S membrane protein (homolog of Drosophila rhomboid)
HKFIFLAF_00422 2.7e-255 cshA 3.6.4.13 JKL DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
HKFIFLAF_00424 3.2e-107 E Lysine exporter protein LysE YggA
HKFIFLAF_00425 9.6e-121 otsB2 2.4.1.64, 3.1.3.12, 3.2.1.28, 5.4.2.6 GH37,GH65 S Haloacid dehalogenase-like hydrolase
HKFIFLAF_00426 4.1e-170 yvdE K Transcriptional regulator
HKFIFLAF_00427 0.0 malL 3.2.1.10, 3.2.1.20 GH13,GH31 G COG0366 Glycosidases
HKFIFLAF_00428 0.0 nplT 3.2.1.133, 3.2.1.135, 3.2.1.54 GH13 G Alpha amylase, N-terminal ig-like domain
HKFIFLAF_00430 2.4e-218 mdxE G COG2182 Maltose-binding periplasmic proteins domains
HKFIFLAF_00431 2.3e-156 malD P transport
HKFIFLAF_00432 3.8e-143 malA S Protein of unknown function (DUF1189)
HKFIFLAF_00433 0.0 yvdK 2.4.1.8 GH65 G Glycoside hydrolase, family 65
HKFIFLAF_00434 0.0 malL 3.2.1.10 GH13 G COG0366 Glycosidases
HKFIFLAF_00435 2.1e-260 murF 6.3.2.10 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
HKFIFLAF_00436 5.7e-197 ddl 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
HKFIFLAF_00437 1.6e-148
HKFIFLAF_00438 2.9e-235 corC1 S COG1253 Hemolysins and related proteins containing CBS domains
HKFIFLAF_00439 4e-78 cueR K transcriptional
HKFIFLAF_00440 7.6e-242 corC1 S COG1253 Hemolysins and related proteins containing CBS domains
HKFIFLAF_00442 4.7e-304 ywqB S Zinc finger, swim domain protein
HKFIFLAF_00443 0.0 ywqA L COG0553 Superfamily II DNA RNA helicases, SNF2 family
HKFIFLAF_00445 1.9e-71 ywpF S YwpF-like protein
HKFIFLAF_00446 3.3e-64 ssbB L Single-stranded DNA-binding protein
HKFIFLAF_00448 8.7e-72 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
HKFIFLAF_00449 5.5e-139 flhP N flagellar basal body
HKFIFLAF_00450 1.1e-144 flhO N flagellar basal body
HKFIFLAF_00451 1.7e-179 mbl D Rod shape-determining protein
HKFIFLAF_00452 6.5e-41 spoIIID K Stage III sporulation protein D
HKFIFLAF_00453 4.1e-128 spoIIQ M COG0739 Membrane proteins related to metalloendopeptidases
HKFIFLAF_00454 2e-183 spoIID D Stage II sporulation protein D
HKFIFLAF_00455 4.5e-08 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HKFIFLAF_00456 1.1e-237 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HKFIFLAF_00457 3.9e-136 ywmB S TATA-box binding
HKFIFLAF_00458 1.8e-34 ywzB S membrane
HKFIFLAF_00459 2.1e-54 atpC C Produces ATP from ADP in the presence of a proton gradient across the membrane
HKFIFLAF_00460 4.4e-261 atpD 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HKFIFLAF_00461 1e-143 atpG C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HKFIFLAF_00462 5.9e-280 atpA 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HKFIFLAF_00463 4.9e-88 atpH C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HKFIFLAF_00464 1.3e-37 atpF C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HKFIFLAF_00465 1.3e-26 atpE C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HKFIFLAF_00466 8.2e-131 atpB C it plays a direct role in the translocation of protons across the membrane
HKFIFLAF_00467 4.1e-52 atpI S ATP synthase I chain
HKFIFLAF_00468 1e-113 upp 2.4.2.9 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HKFIFLAF_00469 3.5e-238 glyA 2.1.2.1 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HKFIFLAF_00470 4.4e-95 ywlG S Belongs to the UPF0340 family
HKFIFLAF_00471 3.1e-80 rpiB 5.3.1.6 G Ribose 5-phosphate isomerase
HKFIFLAF_00472 5.7e-175 mcpA NT Chemotaxis
HKFIFLAF_00473 5.4e-71 ywlE 3.1.3.48, 3.9.1.2, 5.3.1.6 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HKFIFLAF_00474 1.1e-149 L PFAM transposase, IS4 family protein
HKFIFLAF_00477 1.1e-15 S Ribbon-helix-helix protein, copG family
HKFIFLAF_00478 1.1e-129 ytkL S Belongs to the UPF0173 family
HKFIFLAF_00479 5.5e-179 pepQ 3.4.13.9 E COG0006 Xaa-Pro aminopeptidase
HKFIFLAF_00480 2.3e-196 ald 1.4.1.1 E Belongs to the AlaDH PNT family
HKFIFLAF_00481 3.1e-78 uspA T Belongs to the universal stress protein A family
HKFIFLAF_00482 1.2e-149 S EcsC protein family
HKFIFLAF_00483 9.2e-220 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HKFIFLAF_00484 9.9e-175 ytxK 2.1.1.72 L DNA methylase
HKFIFLAF_00485 2.2e-90 tpx 1.11.1.15 O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HKFIFLAF_00486 5.8e-69 ytfJ S Sporulation protein YtfJ
HKFIFLAF_00487 6.1e-120 ytfI S Protein of unknown function (DUF2953)
HKFIFLAF_00488 4.1e-87 yteJ S RDD family
HKFIFLAF_00489 1.6e-185 sppA OU signal peptide peptidase SppA
HKFIFLAF_00490 2.2e-311 acsA 6.2.1.1, 6.2.1.2 I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases
HKFIFLAF_00491 1.4e-27 sspB S spore protein
HKFIFLAF_00492 1.6e-224 thiI 2.8.1.4 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HKFIFLAF_00493 3.1e-212 iscS2 2.8.1.7 E Cysteine desulfurase
HKFIFLAF_00494 9.2e-306 ezrA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HKFIFLAF_00495 4.2e-118 yttP K Transcriptional regulator
HKFIFLAF_00496 5.4e-86 ytsP 1.8.4.14 T GAF domain-containing protein
HKFIFLAF_00497 0.0 ytrP 2.7.7.65 T COG2199 FOG GGDEF domain
HKFIFLAF_00498 1.9e-109 rpsD J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HKFIFLAF_00499 1.3e-145
HKFIFLAF_00500 2e-126
HKFIFLAF_00501 1.8e-181 putA E Proline dehydrogenase
HKFIFLAF_00502 3.3e-294 rocA 1.2.1.88, 1.5.5.2 C Belongs to the aldehyde dehydrogenase family. RocA subfamily
HKFIFLAF_00503 1.9e-253 prdR KT Transcriptional regulator
HKFIFLAF_00504 2.2e-240 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HKFIFLAF_00505 3.6e-151 fdhD C Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HKFIFLAF_00506 0.0 yjgC 1.17.1.10, 1.17.1.9 C formate dehydrogenase, alpha subunit
HKFIFLAF_00507 3.7e-88 yrhD S Protein of unknown function (DUF1641)
HKFIFLAF_00508 2.1e-193 moeB 2.7.7.80 H COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
HKFIFLAF_00509 2.7e-85 moaC 4.6.1.17 H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)
HKFIFLAF_00510 3e-34 moaD 2.8.1.12 H Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HKFIFLAF_00511 3.9e-78 moaE 2.8.1.12 H COG0314 Molybdopterin converting factor, large subunit
HKFIFLAF_00512 7.5e-88 mobB 2.10.1.1, 2.7.7.77 H molybdopterin-guanine dinucleotide biosynthesis protein
HKFIFLAF_00513 3.7e-235 moeA 2.10.1.1 H molybdopterin
HKFIFLAF_00514 2.6e-118 mobA 2.7.7.77 H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
HKFIFLAF_00515 1.7e-82 moaB 2.7.7.75 H May be involved in the biosynthesis of molybdopterin
HKFIFLAF_00516 3.5e-188 moaA 4.1.99.22, 4.6.1.17 H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HKFIFLAF_00517 1.5e-129 modC 3.6.3.29 P ATPases associated with a variety of cellular activities
HKFIFLAF_00518 7.4e-124 P COG4149 ABC-type molybdate transport system, permease component
HKFIFLAF_00519 5.2e-123 modA P Molybdenum ABC transporter
HKFIFLAF_00520 0.0 acsA 6.2.1.1 I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases
HKFIFLAF_00521 4.2e-123 acuA K Part of the acuABC operon, which is possibly involved in the breakdown of acetoin and butanediol. Acts as an acetyltransferase inactivating acetyl-CoA synthetase AcsA via acetylation at a Lys residue
HKFIFLAF_00522 3.8e-119 acuB S Acetoin utilization protein AcuB
HKFIFLAF_00523 1.6e-232 acuC BQ histone deacetylase
HKFIFLAF_00524 8.3e-182 ccpA K catabolite control protein A
HKFIFLAF_00525 1.9e-192 aroF 2.5.1.54, 5.4.99.5 E Catalyzes the formation of 3-deoxy-D-aribino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate and the formation of prephenate from chorismate
HKFIFLAF_00526 7.6e-35 XK27_07760 S COG4980 Gas vesicle protein
HKFIFLAF_00527 5.6e-52 ytxG S protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HKFIFLAF_00528 1.1e-255 mpl 6.3.2.4, 6.3.2.45, 6.3.2.8 M Belongs to the MurCDEF family
HKFIFLAF_00529 0.0 sftA D Belongs to the FtsK SpoIIIE SftA family
HKFIFLAF_00530 6.5e-63 yhcN S Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
HKFIFLAF_00531 6.7e-110 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HKFIFLAF_00532 1.7e-145 ytpQ S Belongs to the UPF0354 family
HKFIFLAF_00533 1.9e-55 ytpP 2.7.1.180, 5.3.4.1 CO Thioredoxin
HKFIFLAF_00534 3.6e-152 rsbU 3.1.3.3 T response regulator
HKFIFLAF_00535 4e-30 cheR 2.1.1.80 NT chemotaxis
HKFIFLAF_00536 1.8e-102 T PhoQ Sensor
HKFIFLAF_00537 1.5e-09 T PhoQ Sensor
HKFIFLAF_00538 3.6e-53 EGP Transmembrane secretion effector
HKFIFLAF_00539 6.1e-142 S transposase or invertase
HKFIFLAF_00540 5.1e-13 S transposase or invertase
HKFIFLAF_00541 1.3e-51 S Domain of unknown function (DUF3870)
HKFIFLAF_00542 1.6e-227 B4168_2380 1.3.99.32 I Acyl-CoA dehydrogenase, N-terminal domain
HKFIFLAF_00543 5e-51 C acyl-CoA transferases carnitine dehydratase
HKFIFLAF_00544 1.9e-144 C acyl-CoA transferases carnitine dehydratase
HKFIFLAF_00545 1.1e-181 yfmJ S N-terminal domain of oxidoreductase
HKFIFLAF_00546 1.1e-12 yfmJ S N-terminal domain of oxidoreductase
HKFIFLAF_00547 1.1e-212 EGP Major facilitator Superfamily
HKFIFLAF_00548 7e-114 2.7.1.202 K transcriptional regulator, MtlR
HKFIFLAF_00549 2.8e-213 licC G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HKFIFLAF_00550 4.8e-252 gph G MFS/sugar transport protein
HKFIFLAF_00551 2e-198 K helix_turn_helix, arabinose operon control protein
HKFIFLAF_00552 1e-193 ydjE EGP Major facilitator superfamily
HKFIFLAF_00553 4.2e-74 K transcriptional
HKFIFLAF_00554 8.7e-210 EGP Major facilitator Superfamily
HKFIFLAF_00555 2.2e-179 K Transcriptional regulator
HKFIFLAF_00556 0.0 bga2 3.2.1.23 G beta-galactosidase
HKFIFLAF_00557 4e-111 opuCD P COG1174 ABC-type proline glycine betaine transport systems, permease component
HKFIFLAF_00558 1.3e-170 opuCC M COG1732 Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
HKFIFLAF_00559 3.4e-115 opuCB P COG1174 ABC-type proline glycine betaine transport systems, permease component
HKFIFLAF_00560 1.7e-210 opuCA E COG1125 ABC-type proline glycine betaine transport systems, ATPase components
HKFIFLAF_00561 2.9e-96 yvbF K Belongs to the GbsR family
HKFIFLAF_00562 1.6e-97 maa 2.3.1.79 S COG0110 Acetyltransferase (isoleucine patch superfamily)
HKFIFLAF_00563 6.4e-188 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
HKFIFLAF_00564 4.6e-45
HKFIFLAF_00565 1.6e-108 yjlB S Cupin domain
HKFIFLAF_00566 2e-141 3.1.1.5 E GDSL-like Lipase/Acylhydrolase
HKFIFLAF_00567 6.3e-131 yflN_1 S Metallo-beta-lactamase superfamily
HKFIFLAF_00568 4e-273 pnbA CE10 I Belongs to the type-B carboxylesterase lipase family
HKFIFLAF_00569 1.8e-295 comM O Mg chelatase subunit ChlI
HKFIFLAF_00570 8.3e-139 S transposase or invertase
HKFIFLAF_00574 3e-20
HKFIFLAF_00575 2.8e-199 gldA 1.1.1.1, 1.1.1.6 C COG0371 Glycerol dehydrogenase and related enzymes
HKFIFLAF_00576 4.4e-208 nadA 2.5.1.72 H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HKFIFLAF_00577 7.6e-160 nadC 1.4.3.16, 2.4.2.19 H Belongs to the NadC ModD family
HKFIFLAF_00578 7.5e-294 nadB 1.3.5.4, 1.4.3.16 H Catalyzes the oxidation of L-aspartate to iminoaspartate
HKFIFLAF_00579 2.1e-205 nifS 2.8.1.7 E Cysteine desulfurase
HKFIFLAF_00580 1.8e-90 S NYN domain
HKFIFLAF_00581 3.7e-18 focA P Formate nitrite
HKFIFLAF_00582 2.8e-108 focA P Formate nitrite
HKFIFLAF_00583 1.6e-222 NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).
HKFIFLAF_00584 6.3e-29 S UPF0397 protein
HKFIFLAF_00585 1.5e-163 salL 2.5.1.63, 2.5.1.94 S S-adenosyl-l-methionine hydroxide adenosyltransferase
HKFIFLAF_00586 5.2e-123 IQ Catalyzes the formation of acetoacetate from 3-hydroxybutyrate
HKFIFLAF_00587 2e-253 EG COG2610 H gluconate symporter and related permeases
HKFIFLAF_00588 3.2e-283 iolA 1.2.1.18, 1.2.1.27 C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
HKFIFLAF_00589 1.7e-221 adhB 1.1.1.1, 1.1.1.202 C alcohol dehydrogenase
HKFIFLAF_00590 0.0 KT Transcriptional regulator
HKFIFLAF_00591 2.6e-21 xylS 3.2.1.20 GH31 G Belongs to the glycosyl hydrolase 31 family
HKFIFLAF_00592 1.5e-12 Otg1 S Predicted membrane protein (DUF2339)
HKFIFLAF_00593 4.7e-85 3.1.4.46, 5.4.2.11 C glycerophosphoryl diester phosphodiesterase
HKFIFLAF_00594 1.6e-86 mntP P Probably functions as a manganese efflux pump
HKFIFLAF_00595 2.7e-191 ywlC 2.7.7.87, 3.1.3.48 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
HKFIFLAF_00596 5.4e-133 spoIIR S Stage II sporulation protein R (spore_II_R)
HKFIFLAF_00597 4.1e-161 prmC 2.1.1.297 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
HKFIFLAF_00598 1.7e-193 prfA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HKFIFLAF_00600 1.3e-110 tdk 2.7.1.21 F thymidine kinase
HKFIFLAF_00601 2.2e-33 rpmE J Ribosomal protein L31
HKFIFLAF_00602 2.7e-230 rho K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HKFIFLAF_00603 7.8e-177 glpX 3.1.3.11, 3.1.3.37 G fructose-1,6-bisphosphatase
HKFIFLAF_00604 5.2e-237 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HKFIFLAF_00605 2.6e-115 tal 2.2.1.2 G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HKFIFLAF_00606 3.6e-157 fbaA 4.1.2.13, 4.1.2.29 G Aldolase
HKFIFLAF_00607 1.3e-60 spo0F T response regulator
HKFIFLAF_00608 3e-199
HKFIFLAF_00609 1.7e-143
HKFIFLAF_00610 8.4e-125 yhcG V ABC transporter, ATP-binding protein
HKFIFLAF_00611 2.3e-66 K helix_turn_helix gluconate operon transcriptional repressor
HKFIFLAF_00612 5.8e-310 pyrG 6.3.4.2 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
HKFIFLAF_00613 3.8e-46 rpoE K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
HKFIFLAF_00615 2.5e-26 V VanZ like family
HKFIFLAF_00617 4.9e-109 V ATPases associated with a variety of cellular activities
HKFIFLAF_00618 1.9e-62 S FtsX-like permease family
HKFIFLAF_00619 9.1e-105 S FtsX-like permease family
HKFIFLAF_00620 1.3e-153 S FtsX-like permease family
HKFIFLAF_00621 7.7e-14 icmF 5.4.99.13 EI Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HKFIFLAF_00622 8e-174 icmF 5.4.99.13 EI Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HKFIFLAF_00623 3.2e-110 kstR2_2 K Transcriptional regulator
HKFIFLAF_00624 3.2e-214 acdA 1.3.8.1, 1.3.8.7 I acyl-CoA dehydrogenase
HKFIFLAF_00625 5.3e-209 mmgC I acyl-CoA dehydrogenase
HKFIFLAF_00626 2.9e-218 mmgA 2.3.1.9 I Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
HKFIFLAF_00627 0.0 fadF C COG0247 Fe-S oxidoreductase
HKFIFLAF_00628 4.7e-216 cls I Belongs to the phospholipase D family. Cardiolipin synthase subfamily
HKFIFLAF_00629 0.0 argS 6.1.1.19 J Arginyl-tRNA synthetase
HKFIFLAF_00630 6.7e-75 ywiB S Domain of unknown function (DUF1934)
HKFIFLAF_00631 1.6e-168 speB 3.5.3.11 E Belongs to the arginase family
HKFIFLAF_00632 0.0 pbpG 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
HKFIFLAF_00633 1.7e-93 ywhD S YwhD family
HKFIFLAF_00634 7.8e-120 ywhC S Peptidase M50
HKFIFLAF_00635 2.7e-25 dmpI 5.3.2.6 G 4-oxalocrotonate tautomerase
HKFIFLAF_00636 6e-91 ywgA 2.1.1.72, 3.1.21.3
HKFIFLAF_00637 6.1e-257 ywfO S COG1078 HD superfamily phosphohydrolases
HKFIFLAF_00638 5.7e-100 rsfA S Transcriptional regulator
HKFIFLAF_00639 1.8e-153 lipL 2.3.1.200, 2.3.1.204 H Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes
HKFIFLAF_00640 8.7e-176 pta 2.3.1.8, 3.6.3.21 C In Salmonella this enzyme is required for ethanolamine catabolism
HKFIFLAF_00641 9.5e-146 ywfI C May function as heme-dependent peroxidase
HKFIFLAF_00642 2.2e-81 gerQ S Essential for the localization of CwlJ in the spore coat and for spore germination triggered by calcium and dipicolinic acid (DPA). Its assembly into the spore coat is dependent on the coat morphogenetic proteins CotE and SpoIVA
HKFIFLAF_00643 1.1e-57 ywdK S small membrane protein
HKFIFLAF_00644 7.2e-37 S Family of unknown function (DUF5327)
HKFIFLAF_00645 2.2e-133 ung 3.2.2.27 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HKFIFLAF_00646 7.9e-55 S Heat induced stress protein YflT
HKFIFLAF_00648 1.7e-274
HKFIFLAF_00649 2.5e-225 3.5.1.47 E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
HKFIFLAF_00650 1.3e-27 yhjC S Protein of unknown function (DUF3311)
HKFIFLAF_00651 7.2e-267 E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HKFIFLAF_00653 3.1e-33 S Protein of unknown function (DUF2933)
HKFIFLAF_00655 8.5e-249 T PhoQ Sensor
HKFIFLAF_00656 1.5e-126 KT COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HKFIFLAF_00657 4.9e-91 ydhK M Protein of unknown function (DUF1541)
HKFIFLAF_00658 1.6e-100 VY92_08700 S Enoyl-(Acyl carrier protein) reductase
HKFIFLAF_00659 7e-12 recN L Putative cell-wall binding lipoprotein
HKFIFLAF_00660 1e-173 nodB1 G deacetylase
HKFIFLAF_00663 3.1e-240 P Voltage gated chloride channel
HKFIFLAF_00664 7.2e-49 P Rhodanese domain protein
HKFIFLAF_00665 1.9e-37 yhjE S protein conserved in bacteria
HKFIFLAF_00666 7.5e-146 yokF 3.1.31.1 L RNA catabolic process
HKFIFLAF_00667 5.2e-71 2.7.1.199 G phosphoenolpyruvate-dependent sugar phosphotransferase system
HKFIFLAF_00668 3.2e-50 NT chemotaxis protein
HKFIFLAF_00669 1.8e-193 NT chemotaxis protein
HKFIFLAF_00670 8.1e-128 plsB 2.3.1.15 I Acyl-transferase
HKFIFLAF_00671 6.7e-201 2.4.1.83 GT2 M Glycosyl transferase family 2
HKFIFLAF_00672 4.7e-132 IQ Enoyl-(Acyl carrier protein) reductase
HKFIFLAF_00673 6e-74 yuiD S protein conserved in bacteria
HKFIFLAF_00674 7.8e-216 solA 1.5.3.1 E FAD dependent oxidoreductase
HKFIFLAF_00675 1.9e-222 FOXRED 1.5.3.1 E FAD dependent oxidoreductase
HKFIFLAF_00676 2e-277 ycbD 1.2.1.3 C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
HKFIFLAF_00677 3.4e-169 4.3.1.12 E ornithine cyclodeaminase
HKFIFLAF_00680 6e-180 yugO P COG1226 Kef-type K transport systems
HKFIFLAF_00681 1.3e-259 pgi 5.3.1.9 G Belongs to the GPI family
HKFIFLAF_00682 5.1e-34 yuzA S Domain of unknown function (DUF378)
HKFIFLAF_00683 3.4e-85 K Bacterial transcription activator, effector binding domain
HKFIFLAF_00684 1.2e-64 yugI 5.3.1.9 J RNA binding protein (contains ribosomal protein S1 domain)
HKFIFLAF_00685 5.9e-29 K Helix-turn-helix XRE-family like proteins
HKFIFLAF_00686 1.6e-196 namA C Catalyzes the reduction of the double bond of an array of alpha,beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes
HKFIFLAF_00687 1.2e-165 S reductase
HKFIFLAF_00688 2.4e-158 dkgB S Aldo/keto reductase family
HKFIFLAF_00689 2.1e-238 S protein conserved in bacteria
HKFIFLAF_00691 2.7e-111 ppiB 5.2.1.8 O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HKFIFLAF_00692 3.4e-67 kapB G Kinase associated protein B
HKFIFLAF_00693 8.8e-194 yuxJ EGP Major facilitator Superfamily
HKFIFLAF_00694 9.4e-65 ydiI Q protein, possibly involved in aromatic compounds catabolism
HKFIFLAF_00695 1.4e-57 yuzC
HKFIFLAF_00697 1.3e-194 E Spore germination protein
HKFIFLAF_00698 4.6e-227 gerKC S spore germination
HKFIFLAF_00699 1.4e-295 gerKA EG Spore germination protein
HKFIFLAF_00701 5.7e-300 pepA 3.4.11.1, 3.4.11.5 E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HKFIFLAF_00702 6.4e-108 yuiC S protein conserved in bacteria
HKFIFLAF_00703 1.2e-46 yuiB S Putative membrane protein
HKFIFLAF_00704 1.4e-228 yumB 1.6.99.3 C NADH dehydrogenase
HKFIFLAF_00705 4.7e-185 yumC 1.18.1.2, 1.19.1.1 C reductase
HKFIFLAF_00706 2.7e-91 S response to antibiotic
HKFIFLAF_00707 0.0 valS 6.1.1.9 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
HKFIFLAF_00708 8.6e-243 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
HKFIFLAF_00710 2.5e-81
HKFIFLAF_00711 2.1e-219 NU Pilus assembly protein PilX
HKFIFLAF_00712 8e-188
HKFIFLAF_00713 3.1e-125 S PRC-barrel domain
HKFIFLAF_00714 3.8e-196 V G5
HKFIFLAF_00715 5.3e-290 pilB NU COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HKFIFLAF_00716 5.3e-195 pilT NU twitching motility protein
HKFIFLAF_00717 6.9e-199 pilC NU type II secretion system
HKFIFLAF_00718 1.2e-44 NU cell adhesion
HKFIFLAF_00719 1.4e-181 NU COG4972 Tfp pilus assembly protein, ATPase PilM
HKFIFLAF_00720 1.6e-85 pilN NU PFAM Fimbrial assembly family protein
HKFIFLAF_00721 2.5e-48
HKFIFLAF_00722 3.8e-142 comC 3.4.23.43 NOU COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases
HKFIFLAF_00723 2.6e-164 spoIIB
HKFIFLAF_00725 1.3e-122 radC E Belongs to the UPF0758 family
HKFIFLAF_00726 1.4e-184 mreB D Rod shape-determining protein MreB
HKFIFLAF_00727 1.1e-140 mreC M Involved in formation and maintenance of cell shape
HKFIFLAF_00728 4e-87 mreD M shape-determining protein
HKFIFLAF_00729 9.7e-121 minC D Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization
HKFIFLAF_00730 9.5e-144 minD D Belongs to the ParA family
HKFIFLAF_00731 7e-133 spoIVFA M COG0739 Membrane proteins related to metalloendopeptidases
HKFIFLAF_00732 1.1e-158 spoIVFB S Stage IV sporulation protein
HKFIFLAF_00733 8.1e-261 rng J ribonuclease, Rne Rng family
HKFIFLAF_00734 1.7e-48 rplU J This protein binds to 23S rRNA in the presence of protein L20
HKFIFLAF_00735 7.8e-52 ysxB J ribosomal protein
HKFIFLAF_00736 1.1e-46 rpmA J Belongs to the bacterial ribosomal protein bL27 family
HKFIFLAF_00737 4.4e-97 spo0B T Sporulation initiation phospho-transferase B, C-terminal
HKFIFLAF_00738 9.9e-244 obg S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HKFIFLAF_00739 1.2e-74 pheB 5.4.99.5 S Belongs to the UPF0735 family
HKFIFLAF_00740 3.9e-156 pheA 4.2.1.51 E Prephenate dehydratase
HKFIFLAF_00741 8.1e-94 niaR S small molecule binding protein (contains 3H domain)
HKFIFLAF_00742 2.3e-136 safA M spore coat assembly protein SafA
HKFIFLAF_00743 2.3e-184 1.1.1.34, 2.7.1.89 M choline kinase involved in LPS biosynthesis
HKFIFLAF_00744 5e-128 yebC K transcriptional regulatory protein
HKFIFLAF_00745 2e-101 ruvA 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
HKFIFLAF_00746 6.8e-184 ruvB 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
HKFIFLAF_00747 3.2e-27 yrzS S Protein of unknown function (DUF2905)
HKFIFLAF_00748 1.8e-192 queA 2.4.99.17 J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HKFIFLAF_00749 5e-223 tgt 2.4.2.29 F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
HKFIFLAF_00750 7.4e-42 yajC U Preprotein translocase subunit YajC
HKFIFLAF_00751 1.9e-60 yrzE S Protein of unknown function (DUF3792)
HKFIFLAF_00752 1.4e-105 yrbG S membrane
HKFIFLAF_00753 6e-272 spoVB S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
HKFIFLAF_00754 4.3e-55 yrzD S Post-transcriptional regulator
HKFIFLAF_00755 0.0 secF U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HKFIFLAF_00756 0.0 recJ L Single-stranded-DNA-specific exonuclease RecJ
HKFIFLAF_00757 1.2e-94 apt 2.4.2.22, 2.4.2.7 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HKFIFLAF_00758 0.0 relA 2.7.6.5 KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HKFIFLAF_00759 8.7e-75 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
HKFIFLAF_00760 9.3e-69 K helix_turn_helix multiple antibiotic resistance protein
HKFIFLAF_00761 7.5e-107 emrA V COG1566 Multidrug resistance efflux pump
HKFIFLAF_00762 8.3e-305 yhcA5 EGP Major facilitator Superfamily
HKFIFLAF_00763 7e-270 lytH 3.5.1.28, 6.1.1.12 M COG3103 SH3 domain protein
HKFIFLAF_00765 7.8e-249 hisS 6.1.1.21 J histidyl-tRNA synthetase
HKFIFLAF_00766 0.0 aspS 6.1.1.12 J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HKFIFLAF_00768 6.5e-163 ybaS 1.1.1.58 S Na -dependent transporter
HKFIFLAF_00769 1.2e-135 yrvM H COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1
HKFIFLAF_00770 2.8e-238 cshA L COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase
HKFIFLAF_00771 8.8e-136 IQ Short-chain dehydrogenase reductase sdr
HKFIFLAF_00772 2.3e-72 cymR K Transcriptional regulator
HKFIFLAF_00773 1.2e-208 iscS 2.8.1.7 E Cysteine desulfurase
HKFIFLAF_00774 3.7e-223 mnmA 2.8.1.13 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
HKFIFLAF_00775 1.3e-125 S COG0457 FOG TPR repeat
HKFIFLAF_00776 0.0 recD2 3.1.11.5 L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
HKFIFLAF_00777 8.2e-73 yndM S Protein of unknown function (DUF2512)
HKFIFLAF_00778 4e-29 yrzR
HKFIFLAF_00780 1.3e-175 yrrI S AI-2E family transporter
HKFIFLAF_00781 0.0 alaS 6.1.1.7 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HKFIFLAF_00782 1.1e-43 yrzL S Belongs to the UPF0297 family
HKFIFLAF_00783 6.8e-69 yqgF L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HKFIFLAF_00784 1.5e-41 yrzB S Belongs to the UPF0473 family
HKFIFLAF_00785 4.2e-203 mltG S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HKFIFLAF_00786 2.8e-114 yrrM 2.1.1.104 S O-methyltransferase
HKFIFLAF_00787 2.6e-112 udk 2.7.1.48 F Cytidine monophosphokinase
HKFIFLAF_00788 1.2e-77 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
HKFIFLAF_00789 7.9e-58 yrrS S Protein of unknown function (DUF1510)
HKFIFLAF_00790 5.8e-29 yrzA S Protein of unknown function (DUF2536)
HKFIFLAF_00791 7.2e-124 mtnN 3.2.2.9 E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HKFIFLAF_00792 1.7e-10 S YrhC-like protein
HKFIFLAF_00794 3.8e-107 ahpC 1.11.1.15 O Alkyl hydroperoxide reductase
HKFIFLAF_00795 2.4e-292 ahpF O Alkyl hydroperoxide reductase
HKFIFLAF_00796 2.8e-126 sigK K sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HKFIFLAF_00797 3e-93 pssA 2.7.8.8 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HKFIFLAF_00798 1.2e-14 sda S Sporulation inhibitor A
HKFIFLAF_00799 5.1e-154 czcD P COG1230 Co Zn Cd efflux system component
HKFIFLAF_00800 1.6e-118 S VIT family
HKFIFLAF_00801 1.2e-57 crcB D Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HKFIFLAF_00802 2e-56 crcB D Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HKFIFLAF_00803 6.5e-78 lemA S LemA family
HKFIFLAF_00804 1.1e-115 S TPM domain
HKFIFLAF_00805 3.4e-106 CO alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HKFIFLAF_00806 2.7e-22 S Short C-terminal domain
HKFIFLAF_00807 3.9e-75 hsp18 O Belongs to the small heat shock protein (HSP20) family
HKFIFLAF_00808 1.3e-225 mco 1.16.3.3 Q multicopper oxidases
HKFIFLAF_00809 4.6e-205 ysfB KT regulator
HKFIFLAF_00810 8.2e-260 glcD 1.1.3.15 C Glycolate oxidase subunit
HKFIFLAF_00811 5.1e-259 glcF C Glycolate oxidase
HKFIFLAF_00812 2.9e-93 yqeG S hydrolase of the HAD superfamily
HKFIFLAF_00813 3.5e-213 yqeH S In Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis
HKFIFLAF_00814 2.3e-161 aroE 1.1.1.25 E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HKFIFLAF_00815 8.1e-45 yhbY J RNA-binding protein containing KH domain, possibly ribosomal protein
HKFIFLAF_00816 1.5e-106 nadD 2.7.7.18, 3.6.1.55 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HKFIFLAF_00817 3.1e-101 nadD 2.7.6.3, 2.7.7.18 H HD superfamily hydrolase involved in NAD metabolism
HKFIFLAF_00818 1.1e-59 rsfS J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
HKFIFLAF_00819 3.6e-145 cmoA S Methyltransferase domain
HKFIFLAF_00820 1.4e-147 comER E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HKFIFLAF_00821 1.2e-92 comEA L COG1555 DNA uptake protein and related DNA-binding proteins
HKFIFLAF_00822 2.1e-111 comEB 3.5.4.12 F COG2131 Deoxycytidylate deaminase
HKFIFLAF_00823 0.0 comEC S Competence protein ComEC
HKFIFLAF_00824 1.1e-07 S YqzM-like protein
HKFIFLAF_00825 2.2e-185 holA 2.7.7.7 L DNA polymerase III delta subunit
HKFIFLAF_00826 7.5e-34 rpsT J Binds directly to 16S ribosomal RNA
HKFIFLAF_00827 1.4e-201 gpr 3.4.24.78 C Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HKFIFLAF_00828 2.4e-220 spoIIP M stage II sporulation protein P
HKFIFLAF_00829 0.0 lepA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
HKFIFLAF_00830 9.7e-219 hemN H Involved in the biosynthesis of porphyrin-containing compound
HKFIFLAF_00831 7e-184 hrcA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
HKFIFLAF_00832 4.2e-89 grpE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HKFIFLAF_00833 2.1e-308 dnaK O Heat shock 70 kDa protein
HKFIFLAF_00834 3.8e-207 dnaJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
HKFIFLAF_00835 2.5e-172 prmA J Methylates ribosomal protein L11
HKFIFLAF_00836 2.7e-140 rsmE 2.1.1.193 J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
HKFIFLAF_00837 4.2e-261 yqeV 2.8.4.5 J ribosomal protein S12 methylthiotransferase
HKFIFLAF_00838 4.3e-156 yqeW P COG1283 Na phosphate symporter
HKFIFLAF_00839 2.9e-47 acyP 3.6.1.7 C Belongs to the acylphosphatase family
HKFIFLAF_00840 1.2e-19 rpsU J Belongs to the bacterial ribosomal protein bS21 family
HKFIFLAF_00841 6.6e-70 yqeY S Yqey-like protein
HKFIFLAF_00842 3.2e-46 yqfC S sporulation protein YqfC
HKFIFLAF_00843 1.2e-224 yqfD 3.1.3.102, 3.1.3.104 S Stage IV sporulation
HKFIFLAF_00844 6.1e-174 phoH T Phosphate starvation-inducible protein PhoH
HKFIFLAF_00845 0.0 yqfF S membrane-associated HD superfamily hydrolase
HKFIFLAF_00846 4.2e-83 ybeY 2.6.99.2, 3.5.4.5 S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HKFIFLAF_00847 7.9e-67 dgkA 2.7.1.107, 2.7.1.66 M Diacylglycerol kinase
HKFIFLAF_00848 1.9e-169 era S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HKFIFLAF_00849 6.7e-08 S YqzL-like protein
HKFIFLAF_00850 1.1e-144 recO L Involved in DNA repair and RecF pathway recombination
HKFIFLAF_00851 3.4e-112 ccpN K CBS domain
HKFIFLAF_00852 1.3e-145 yqfL 2.7.11.33, 2.7.4.28 S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation
HKFIFLAF_00853 0.0 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
HKFIFLAF_00854 2.8e-202 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
HKFIFLAF_00855 5.8e-89
HKFIFLAF_00856 1.5e-64 cccA C Cytochrome C oxidase, cbb3-type, subunit III
HKFIFLAF_00857 1.7e-114 trmK 2.1.1.217 S SAM-dependent methyltransferase
HKFIFLAF_00858 2.6e-208 yqfO 3.5.4.16 S Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HKFIFLAF_00859 8.3e-179 ispH 1.17.7.4, 2.7.4.25 IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HKFIFLAF_00862 1.7e-238 cshB 3.6.4.13 JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
HKFIFLAF_00863 3.9e-170 nfo 3.1.21.2 L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HKFIFLAF_00864 4.9e-124 usp CBM50 M protein conserved in bacteria
HKFIFLAF_00865 1.3e-19 yqfT S Protein of unknown function (DUF2624)
HKFIFLAF_00866 6.4e-142 zurA P 'COG1121 ABC-type Mn Zn transport systems, ATPase component'
HKFIFLAF_00867 5.7e-139 znuB P COG1108 ABC-type Mn2 Zn2 transport systems, permease components
HKFIFLAF_00868 2.2e-75 zur P Belongs to the Fur family
HKFIFLAF_00869 1.2e-111 yqfW S Belongs to the 5'(3')-deoxyribonucleotidase family
HKFIFLAF_00870 5.2e-201 ispG 1.17.7.1, 1.17.7.3 I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HKFIFLAF_00871 3.4e-55 fimV NU Tfp pilus assembly protein FimV
HKFIFLAF_00872 6.3e-116 sodA 1.15.1.1 P radicals which are normally produced within the cells and which are toxic to biological systems
HKFIFLAF_00873 1.4e-218 yqgE EGP Major facilitator superfamily
HKFIFLAF_00874 0.0 mrdA 3.4.16.4 M penicillin-binding protein
HKFIFLAF_00875 4.1e-54 yqzD
HKFIFLAF_00876 1.6e-20 rpmG J Belongs to the bacterial ribosomal protein bL33 family
HKFIFLAF_00878 4.6e-200 gluP 3.4.21.105 O membrane protein (homolog of Drosophila rhomboid)
HKFIFLAF_00879 3.3e-30 yqgQ S protein conserved in bacteria
HKFIFLAF_00880 2.1e-169 glcK 2.7.1.2 G Glucokinase
HKFIFLAF_00881 1.7e-21 yqgW S Protein of unknown function (DUF2759)
HKFIFLAF_00882 9.4e-123 ycbL 3.1.2.6 S COG0491 Zn-dependent hydrolases, including glyoxylases
HKFIFLAF_00883 5.7e-36 yqgY S Protein of unknown function (DUF2626)
HKFIFLAF_00884 3.1e-130 K Helix-turn-helix domain
HKFIFLAF_00885 7.4e-211 comGA NU COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HKFIFLAF_00886 4.3e-175 comGB NU COG1459 Type II secretory pathway, component PulF
HKFIFLAF_00887 5.3e-50 comGC U Required for transformation and DNA binding
HKFIFLAF_00888 7.9e-76 gspH NU COG2165 Type II secretory pathway, pseudopilin PulG
HKFIFLAF_00890 3.6e-82 comGF U COG4940 Competence protein ComGF
HKFIFLAF_00891 3.6e-58 S ComG operon protein 7
HKFIFLAF_00892 1.3e-99 aroK 2.7.1.71, 4.2.3.4 F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HKFIFLAF_00893 1.1e-09 yqzE S YqzE-like protein
HKFIFLAF_00894 1.2e-154 yqhG S Bacterial protein YqhG of unknown function
HKFIFLAF_00895 0.0 yqhH L COG0553 Superfamily II DNA RNA helicases, SNF2 family
HKFIFLAF_00896 5.4e-214 gcvT 1.4.4.2, 2.1.2.10 E The glycine cleavage system catalyzes the degradation of glycine
HKFIFLAF_00897 5.3e-256 gcvPA 1.4.4.2 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HKFIFLAF_00898 3.7e-287 gcvPB 1.4.4.2 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HKFIFLAF_00899 4.5e-67 yqhL P COG0607 Rhodanese-related sulfurtransferase
HKFIFLAF_00900 1.7e-159 lipM 6.3.1.20 H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation
HKFIFLAF_00901 0.0 nrdA 1.17.4.1 F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen
HKFIFLAF_00902 2.3e-71 bktB 2.3.1.9 I Belongs to the thiolase family
HKFIFLAF_00903 4.3e-166 yqhO S esterase of the alpha-beta hydrolase superfamily
HKFIFLAF_00904 6.7e-12 yqhP
HKFIFLAF_00905 1.5e-164 yqhQ S Protein of unknown function (DUF1385)
HKFIFLAF_00906 9.1e-86 yqhR S Conserved membrane protein YqhR
HKFIFLAF_00907 9.6e-77 aroQ 4.2.1.10 E Catalyzes a trans-dehydration via an enolate intermediate
HKFIFLAF_00908 1.4e-155 yqhT 3.4.11.9, 3.4.13.9 E COG0006 Xaa-Pro aminopeptidase
HKFIFLAF_00909 1.1e-98 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HKFIFLAF_00910 2.1e-171 spoIIIAA S stage III sporulation protein AA
HKFIFLAF_00911 1.2e-83 spoIIIAB S Stage III sporulation protein
HKFIFLAF_00912 1.4e-27 spoIIIAC S stage III sporulation protein AC
HKFIFLAF_00913 2.3e-58 spoIIIAD S Stage III sporulation protein AD
HKFIFLAF_00914 1.3e-173 spoIIIAE S stage III sporulation protein AE
HKFIFLAF_00915 1.8e-105 spoIIIAF S Stage III sporulation protein AF (Spore_III_AF)
HKFIFLAF_00916 6.6e-111 spoIIIAG S stage III sporulation protein AG
HKFIFLAF_00917 8.2e-67 spoIIIAH S SpoIIIAH-like protein
HKFIFLAF_00918 5.2e-81 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
HKFIFLAF_00919 8.1e-257 accC 6.3.4.14, 6.3.4.6, 6.4.1.2 I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
HKFIFLAF_00920 1.1e-68 yqhY S protein conserved in bacteria
HKFIFLAF_00921 1.6e-64 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HKFIFLAF_00922 3.3e-155 folD 1.5.1.5, 3.5.4.9 F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HKFIFLAF_00923 1.1e-224 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HKFIFLAF_00924 3.1e-31 xseB 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HKFIFLAF_00925 5.4e-153 ispA 2.5.1.1, 2.5.1.10, 2.5.1.29, 2.5.1.90 H Belongs to the FPP GGPP synthase family
HKFIFLAF_00926 0.0 dxs 2.2.1.7 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HKFIFLAF_00927 2.9e-148 rrmJ 2.1.1.226, 2.1.1.227 J rRNA methylase
HKFIFLAF_00928 5.4e-80 argR K Regulates arginine biosynthesis genes
HKFIFLAF_00929 5e-296 recN L May be involved in recombinational repair of damaged DNA
HKFIFLAF_00930 4e-237 rseP 3.4.21.116 M Stage IV sporulation protein B
HKFIFLAF_00931 1.5e-138 KT May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process
HKFIFLAF_00932 4.4e-135 yqiK 3.1.4.46 C glycerophosphoryl diester phosphodiesterase
HKFIFLAF_00933 1.3e-35 yqzF S Protein of unknown function (DUF2627)
HKFIFLAF_00934 1.2e-65 bkdR 2.7.13.3 KT Transcriptional regulator
HKFIFLAF_00935 4.4e-18 T transcription factor binding
HKFIFLAF_00936 1.5e-208 ldh 1.4.1.9 E Belongs to the Glu Leu Phe Val dehydrogenases family
HKFIFLAF_00937 2.3e-262 lpdA 1.8.1.4 C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
HKFIFLAF_00938 5.9e-188 bfmBAA 1.2.4.4 C COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
HKFIFLAF_00939 3.9e-184 bfmBAB 1.2.4.1, 1.2.4.4 C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
HKFIFLAF_00940 1.3e-213 bfmBB 2.3.1.168, 2.3.1.61 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
HKFIFLAF_00941 2.9e-165 fruK 2.7.1.11, 2.7.1.56 G Belongs to the carbohydrate kinase PfkB family
HKFIFLAF_00942 2.1e-76 yqiW S Belongs to the UPF0403 family
HKFIFLAF_00943 7.3e-94 yqjB S protein conserved in bacteria
HKFIFLAF_00944 9.6e-203 yqjE 3.4.11.4 E COG2195 Di- and tripeptidases
HKFIFLAF_00945 2e-77 cheW NT COG0835 Chemotaxis signal transduction protein
HKFIFLAF_00946 1e-226 dinB 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HKFIFLAF_00947 6.4e-295 zwf 1.1.1.363, 1.1.1.49 G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HKFIFLAF_00948 2.5e-172 rnz 3.1.26.11 S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
HKFIFLAF_00949 4.8e-143 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HKFIFLAF_00950 4.5e-146 yqjQ S Belongs to the short-chain dehydrogenases reductases (SDR) family
HKFIFLAF_00951 1.3e-240 polYB 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HKFIFLAF_00952 2.7e-55 S YolD-like protein
HKFIFLAF_00953 2.4e-235 yaaH_2 M Glycoside Hydrolase Family
HKFIFLAF_00954 1.7e-176 yqkD S COG1073 Hydrolases of the alpha beta superfamily
HKFIFLAF_00955 1.3e-213 yaaN P Belongs to the TelA family
HKFIFLAF_00956 2.1e-109 xpaC S 5-bromo-4-chloroindolyl phosphate hydrolysis protein
HKFIFLAF_00957 7.8e-09 S Protein of unknown function (DUF3886)
HKFIFLAF_00958 2.5e-164 yqkF C oxidoreductases (related to aryl-alcohol dehydrogenases)
HKFIFLAF_00960 1.6e-97 nudF 3.6.1.13 L Belongs to the Nudix hydrolase family
HKFIFLAF_00961 2e-227 yqxK 3.6.4.12 L DNA helicase
HKFIFLAF_00962 3.4e-104 spoIIM S Required for complete septum migration and engulfment of the forespore compartment during sporulation. Required for stabilizing and recruiting of SpoIIP to the septal membrane
HKFIFLAF_00963 1.6e-85 fur P Belongs to the Fur family
HKFIFLAF_00964 1.7e-34 S Protein of unknown function (DUF4227)
HKFIFLAF_00965 8e-168 xerD L recombinase XerD
HKFIFLAF_00967 4.9e-210 dacF 3.4.16.4 M Belongs to the peptidase S11 family
HKFIFLAF_00968 2.5e-56 spoIIAA T Belongs to the anti-sigma-factor antagonist family
HKFIFLAF_00969 1.8e-75 spoIIAB 2.7.11.1 F Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition
HKFIFLAF_00970 4.2e-133 sigF K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HKFIFLAF_00971 6.5e-108 spoVAA S Stage V sporulation protein AA
HKFIFLAF_00972 2.7e-65 spoVAB S Stage V sporulation protein AB
HKFIFLAF_00973 2.3e-104 spoVAEA S Stage V sporulation protein AE
HKFIFLAF_00974 7e-270 spoVAF EG Stage V sporulation protein AF
HKFIFLAF_00975 1.9e-251 lysA 4.1.1.19, 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
HKFIFLAF_00976 2.2e-60 ribT K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HKFIFLAF_00978 7.2e-130 scpA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HKFIFLAF_00979 1.2e-106 scpB D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HKFIFLAF_00980 8.1e-202 dacB 3.4.16.4 M Belongs to the peptidase S11 family
HKFIFLAF_00981 8.8e-96 spmA S Spore maturation protein
HKFIFLAF_00982 1.9e-87 spmB S Spore maturation protein
HKFIFLAF_00983 2.9e-131 rluB 5.4.99.19, 5.4.99.21, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
HKFIFLAF_00984 2.8e-99 resA CO Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c
HKFIFLAF_00985 0.0 ccs1 O COG1333 ResB protein required for cytochrome c biosynthesis
HKFIFLAF_00986 2.2e-229 ccsA O 'COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component'
HKFIFLAF_00987 3.3e-132 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HKFIFLAF_00988 0.0 resE 2.7.13.3 T Histidine kinase
HKFIFLAF_00989 2.5e-132 M COG0739 Membrane proteins related to metalloendopeptidases
HKFIFLAF_00990 1.6e-97 fmnP U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HKFIFLAF_00991 7.8e-41 fer C Ferredoxin
HKFIFLAF_00992 3.6e-207 ypbB 5.1.3.1 S protein conserved in bacteria
HKFIFLAF_00993 3.7e-279 recQ 3.6.4.12 L DNA helicase
HKFIFLAF_00994 1.1e-101 ypbD S metal-dependent membrane protease
HKFIFLAF_00996 1.2e-79 ypbF S Protein of unknown function (DUF2663)
HKFIFLAF_00997 1.5e-103 cotJC P Spore Coat
HKFIFLAF_00998 1.2e-44 cotJB S CotJB protein
HKFIFLAF_00999 1.4e-31 cotJA S Spore coat associated protein JA (CotJA)
HKFIFLAF_01000 3.4e-146 ypbG S Calcineurin-like phosphoesterase superfamily domain
HKFIFLAF_01001 8.5e-96 mecB NOT Negative regulator of genetic competence (MecA)
HKFIFLAF_01002 1.2e-244 gudB 1.4.1.2, 1.4.1.3 E Belongs to the Glu Leu Phe Val dehydrogenases family
HKFIFLAF_01003 4.3e-191 ypdA 1.18.1.2, 1.19.1.1, 1.8.1.9 O COG0492 Thioredoxin reductase
HKFIFLAF_01004 1.5e-126 prsW S Involved in the degradation of specific anti-sigma factors
HKFIFLAF_01005 3.7e-148 sleB 3.5.1.28 M Spore cortex-lytic enzyme
HKFIFLAF_01006 8.1e-257 hemX 2.1.1.107, 4.2.1.75 H sporulation protein
HKFIFLAF_01007 1e-116 ypfA M Flagellar protein YcgR
HKFIFLAF_01008 1.1e-119 cmk 1.17.7.4, 2.5.1.19, 2.7.1.26, 2.7.4.25, 2.7.7.2, 6.3.2.1 F Belongs to the cytidylate kinase family. Type 1 subfamily
HKFIFLAF_01009 3.6e-205 rpsA 1.17.7.4 J Ribosomal protein S1
HKFIFLAF_01010 7.3e-14 S YpzI-like protein
HKFIFLAF_01011 8.3e-20 yphA
HKFIFLAF_01012 5.5e-250 der 1.1.1.399, 1.1.1.95 S GTPase that plays an essential role in the late steps of ribosome biogenesis
HKFIFLAF_01013 2.3e-190 gpsA 1.1.1.94 I Glycerol-3-phosphate dehydrogenase
HKFIFLAF_01014 3.2e-08 yphE S Protein of unknown function (DUF2768)
HKFIFLAF_01015 7.6e-137 yphF
HKFIFLAF_01016 3.2e-278 spoIVA S ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HKFIFLAF_01017 3.9e-41 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
HKFIFLAF_01018 8.7e-34 mtrB K Required for transcription attenuation control in the Trp operon. This trans-acting factor seems to recognize a 10 bases nucleotide sequence in the Trp leader transcript causing transcription termination. Binds the leader RNA only in presence of L-tryptophan
HKFIFLAF_01019 3.5e-146 hepS 2.5.1.30 H Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1
HKFIFLAF_01020 6.2e-131 menG 2.1.1.163, 2.1.1.201 H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)
HKFIFLAF_01021 5.2e-173 hepT 2.5.1.30, 2.5.1.83, 2.5.1.90 H Belongs to the FPP GGPP synthase family
HKFIFLAF_01022 4.2e-77 ndk 2.7.4.6 F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
HKFIFLAF_01023 1.7e-145 cheR 2.1.1.80 NT COG1352 Methylase of chemotaxis methyl-accepting proteins
HKFIFLAF_01024 5.3e-220 aroC 4.2.3.5 E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HKFIFLAF_01025 2.1e-207 aroB 2.7.1.71, 4.2.3.4 E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HKFIFLAF_01026 3.8e-60 aroH 2.7.4.25, 5.4.99.5 E Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis
HKFIFLAF_01027 8.8e-209 hisC 2.6.1.9 E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HKFIFLAF_01028 2.6e-205 tyrA 1.3.1.12, 1.3.1.43 E prephenate dehydrogenase
HKFIFLAF_01029 1.1e-237 aroA 1.3.1.12, 1.3.1.43, 2.5.1.19 E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
HKFIFLAF_01030 5e-240 S COG0457 FOG TPR repeat
HKFIFLAF_01031 3.5e-97 ypiB S Belongs to the UPF0302 family
HKFIFLAF_01032 1.1e-80 ypiF S Protein of unknown function (DUF2487)
HKFIFLAF_01033 1e-98 qcrA C Menaquinol-cytochrome c reductase
HKFIFLAF_01034 1.2e-126 petB C COG1290 Cytochrome b subunit of the bc complex
HKFIFLAF_01035 3.3e-146 qcrC C Menaquinol-cytochrome c reductase cytochrome b c subunit
HKFIFLAF_01036 4.9e-37 ypjA S membrane
HKFIFLAF_01037 5.9e-61 ypjA S membrane
HKFIFLAF_01038 6e-143 ypjB S sporulation protein
HKFIFLAF_01039 2.4e-103 yugP S Zn-dependent protease
HKFIFLAF_01040 3.1e-81 queT S QueT transporter
HKFIFLAF_01041 2.4e-161 ypjC S Uncharacterized protein conserved in bacteria (DUF2179)
HKFIFLAF_01042 9.9e-58 ypjD 2.5.1.19 S Nucleotide pyrophosphohydrolase
HKFIFLAF_01043 1.5e-149 dapB 1.17.1.8 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
HKFIFLAF_01044 5.6e-132 bshB1 S proteins, LmbE homologs
HKFIFLAF_01045 1.3e-213 bshA GT4 M N-acetyl-alpha-D-glucosaminyl L-malate synthase
HKFIFLAF_01046 2.8e-224 cca 2.7.7.19, 2.7.7.72 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HKFIFLAF_01047 5.3e-181 birA 6.3.4.15 K Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
HKFIFLAF_01048 7.1e-150 panB 2.1.2.11 H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
HKFIFLAF_01049 6.6e-159 panC 2.7.4.25, 6.3.2.1 H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HKFIFLAF_01050 7.9e-64 panD 4.1.1.11 H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HKFIFLAF_01051 0.0 dinG 2.7.7.7, 3.6.4.12 L helicase involved in DNA repair and perhaps also replication
HKFIFLAF_01052 8.7e-78 ypmB S protein conserved in bacteria
HKFIFLAF_01053 1.4e-215 aspB 2.6.1.1, 2.6.1.14 E Aminotransferase
HKFIFLAF_01054 2.4e-261 asnS 6.1.1.22 J asparaginyl-tRNA
HKFIFLAF_01055 1.5e-129 dnaD L DNA replication protein DnaD
HKFIFLAF_01056 2.9e-122 nth 4.2.99.18 L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HKFIFLAF_01057 0.0 ponA 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
HKFIFLAF_01058 5.5e-112 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
HKFIFLAF_01061 1.1e-62 yppE S Bacterial domain of unknown function (DUF1798)
HKFIFLAF_01062 9.2e-57 yppG S YppG-like protein
HKFIFLAF_01064 5.7e-74 hspX O Belongs to the small heat shock protein (HSP20) family
HKFIFLAF_01065 0.0 yprA L COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster
HKFIFLAF_01066 3.3e-255 yprB L RNase_H superfamily
HKFIFLAF_01068 5.4e-45 cotD S Inner spore coat protein D
HKFIFLAF_01069 1.2e-100 ypsA S Belongs to the UPF0398 family
HKFIFLAF_01070 9e-47 gpsB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
HKFIFLAF_01071 4.5e-224 rlmL 2.1.1.173, 2.1.1.264 L Belongs to the methyltransferase superfamily
HKFIFLAF_01072 4.4e-299 ypwA 3.4.17.19 E Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HKFIFLAF_01073 5.5e-101 xpt 2.4.2.22, 2.4.2.7 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
HKFIFLAF_01074 8e-233 pbuX F xanthine
HKFIFLAF_01075 5.4e-142 f42a O prohibitin homologues
HKFIFLAF_01076 4.2e-32
HKFIFLAF_01077 0.0 S Dynamin family
HKFIFLAF_01078 6.1e-64 glnR K transcriptional
HKFIFLAF_01079 2.2e-262 glnA 6.3.1.2 E glutamine synthetase
HKFIFLAF_01082 4e-74 ligA 2.7.7.7, 6.5.1.2 L PFAM BRCA1 C Terminus (BRCT) domain
HKFIFLAF_01083 9.4e-11 S Protein of unknown function (DUF4064)
HKFIFLAF_01084 3.3e-33 K transcriptional
HKFIFLAF_01085 6.1e-27 K Helix-turn-helix XRE-family like proteins
HKFIFLAF_01086 8.8e-270 gabD 1.2.1.16, 1.2.1.20, 1.2.1.79 C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
HKFIFLAF_01087 8.4e-100 glnH ET COG0834 ABC-type amino acid transport signal transduction systems, periplasmic component domain
HKFIFLAF_01088 9.9e-83 yecS_2 E COG0765 ABC-type amino acid transport system, permease component
HKFIFLAF_01089 9.5e-111 artM_2 3.6.3.21 E ABC transporter
HKFIFLAF_01090 1.2e-277 yobO M Pectate lyase superfamily protein
HKFIFLAF_01091 1.3e-08
HKFIFLAF_01092 2.3e-141 cysH 1.8.4.10, 1.8.4.8, 2.7.1.25 EH Belongs to the PAPS reductase family. CysH subfamily
HKFIFLAF_01093 8.4e-142 hemD 2.1.1.107, 4.2.1.75 H Belongs to the precorrin methyltransferase family
HKFIFLAF_01094 3.7e-126 cbiX 4.99.1.3, 4.99.1.4, 5.4.99.60, 5.4.99.61 S Sirohydrochlorin ferrochelatase
HKFIFLAF_01095 5.2e-105 cysG 1.3.1.76, 4.99.1.4 H Siroheme synthase
HKFIFLAF_01096 3.1e-95 ywhH S Aminoacyl-tRNA editing domain
HKFIFLAF_01097 1.7e-204 gldA 1.1.1.6 C COG0371 Glycerol dehydrogenase and related enzymes
HKFIFLAF_01098 5.4e-308 IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
HKFIFLAF_01100 9.2e-167 EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
HKFIFLAF_01102 7.3e-177 S Nuclease-related domain
HKFIFLAF_01103 3.1e-89
HKFIFLAF_01104 4.8e-171 czcD P COG1230 Co Zn Cd efflux system component
HKFIFLAF_01105 0.0 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
HKFIFLAF_01106 7.1e-144 M Glycosyltransferase like family 2
HKFIFLAF_01107 5.3e-29 M Glycosyltransferase like family 2
HKFIFLAF_01108 1.8e-56 M Glycosyltransferase like family 2
HKFIFLAF_01109 4.8e-171 mvk 1.1.1.88, 2.3.3.10, 2.7.1.36 I GHMP kinases C terminal
HKFIFLAF_01110 2.6e-180 mvaD 4.1.1.33 I GHMP kinases N terminal domain
HKFIFLAF_01111 5.5e-203 mvaK2 2.7.1.36, 2.7.1.43, 2.7.4.2 I GHMP kinases C terminal
HKFIFLAF_01114 9e-113 yhfK GM NmrA-like family
HKFIFLAF_01115 2.5e-28 K PTS system fructose IIA component
HKFIFLAF_01116 4.9e-64 KT Sigma-54 interaction domain
HKFIFLAF_01117 4.8e-229 patB 4.4.1.8 E COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
HKFIFLAF_01118 3.9e-108 4.1.1.44 S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HKFIFLAF_01119 2.3e-38 gcvR T Belongs to the UPF0237 family
HKFIFLAF_01120 4.8e-249 XK27_08635 S UPF0210 protein
HKFIFLAF_01121 2.8e-94 hxlB 4.1.2.14, 4.1.2.43, 4.1.3.42, 5.3.1.27 M SIS domain
HKFIFLAF_01122 3.4e-83 cotF M Spore coat protein
HKFIFLAF_01123 1.9e-175 iolS C Aldo keto reductase
HKFIFLAF_01124 3.8e-99 ydjA C Nitroreductase family
HKFIFLAF_01125 1.2e-252 E COG1113 Gamma-aminobutyrate permease and related permeases
HKFIFLAF_01126 1.7e-17
HKFIFLAF_01127 4.5e-272 dtpT E amino acid peptide transporter
HKFIFLAF_01128 3.2e-278 lysP E amino acid
HKFIFLAF_01130 4.3e-98 puuR K Cupin domain
HKFIFLAF_01131 1.2e-210 potA 3.6.3.30, 3.6.3.31 P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
HKFIFLAF_01132 1.1e-139 potB E COG1176 ABC-type spermidine putrescine transport system, permease component I
HKFIFLAF_01133 5.4e-139 potC E COG1177 ABC-type spermidine putrescine transport system, permease component II
HKFIFLAF_01134 4.1e-203 potD E COG0687 Spermidine putrescine-binding periplasmic protein
HKFIFLAF_01136 4.5e-250 H HemY protein
HKFIFLAF_01137 5.8e-132 frnE Q dithiol-disulfide isomerase involved in polyketide biosynthesis
HKFIFLAF_01138 3.7e-91 yebE S UPF0316 protein
HKFIFLAF_01139 3e-28 yebG S NETI protein
HKFIFLAF_01140 1.1e-81 purE 5.4.99.18 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HKFIFLAF_01141 1.9e-217 purK 6.3.4.18 F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HKFIFLAF_01142 5.6e-247 purB 4.3.2.2 F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HKFIFLAF_01143 7.9e-126 purC 4.1.1.21, 4.3.2.2, 6.3.2.6 F Belongs to the SAICAR synthetase family
HKFIFLAF_01144 9e-40 purS 6.3.2.6, 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HKFIFLAF_01145 2e-126 purQ 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HKFIFLAF_01146 0.0 purL 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HKFIFLAF_01147 2.1e-271 purF 2.4.2.14 F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HKFIFLAF_01148 1.6e-191 purM 6.3.3.1, 6.3.4.13 F Phosphoribosylformylglycinamidine cyclo-ligase
HKFIFLAF_01149 9.2e-104 purN 2.1.2.2 F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HKFIFLAF_01150 5e-287 purH 2.1.2.3, 3.5.4.10 F Bifunctional purine biosynthesis protein PurH
HKFIFLAF_01151 1e-229 purD 6.3.4.13 F Belongs to the GARS family
HKFIFLAF_01152 1.2e-35 S Protein of unknown function (DUF2892)
HKFIFLAF_01153 0.0 yerA 3.5.4.2 F adenine deaminase
HKFIFLAF_01154 2.4e-189 yerB S Protein of unknown function (DUF3048) C-terminal domain
HKFIFLAF_01155 2.4e-53 yerC S protein conserved in bacteria
HKFIFLAF_01156 1.7e-128 pcrB I 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HKFIFLAF_01157 7.7e-126 pcrA 3.6.4.12 L AAA domain
HKFIFLAF_01158 1.9e-211 L RNA-directed DNA polymerase (reverse transcriptase)
HKFIFLAF_01159 1.2e-283 pcrA 3.6.4.12 L ATP-dependent DNA helicase
HKFIFLAF_01160 0.0 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HKFIFLAF_01161 7.9e-216 camS S COG4851 Protein involved in sex pheromone biosynthesis
HKFIFLAF_01162 0.0 aceB 2.3.3.9 C Belongs to the malate synthase family
HKFIFLAF_01163 8.8e-245 aceA 4.1.3.1 C Isocitrate lyase
HKFIFLAF_01164 4.3e-46 gatC 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HKFIFLAF_01165 4.6e-274 gatA 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
HKFIFLAF_01166 3.3e-272 gatB 6.1.1.12, 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HKFIFLAF_01169 1.7e-148 Q N-acetyltransferase
HKFIFLAF_01170 9.3e-172 yegS 2.7.1.107 I COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
HKFIFLAF_01171 2.3e-268 putP E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HKFIFLAF_01172 2.3e-259 rumA 2.1.1.190 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HKFIFLAF_01173 1.5e-57 K Transcriptional regulator
HKFIFLAF_01174 9.7e-246 1.2.1.3 C Belongs to the aldehyde dehydrogenase family
HKFIFLAF_01175 8.5e-181 1.1.1.1 C Iron-containing alcohol dehydrogenase
HKFIFLAF_01176 5.8e-235 MA20_02535 IP Flavin-binding monooxygenase-like
HKFIFLAF_01177 1.2e-15 yxjI S LURP-one-related
HKFIFLAF_01178 5.2e-122 L PFAM Transposase, IS4-like
HKFIFLAF_01179 1.8e-50 L PFAM Transposase, IS4-like
HKFIFLAF_01180 7.5e-12 L PFAM Transposase, IS4-like
HKFIFLAF_01181 1.4e-160 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
HKFIFLAF_01182 9.9e-157 spsE 2.5.1.56 M acid synthase
HKFIFLAF_01183 1.4e-234 spsG 2.7.7.43 M Cytidylyltransferase
HKFIFLAF_01184 8e-113 S polysaccharide biosynthetic process
HKFIFLAF_01186 3.5e-85 M Glycosyltransferase, group 2 family protein
HKFIFLAF_01187 1.5e-91 M Core-2/I-Branching enzyme
HKFIFLAF_01189 1.4e-79 tuaA M COG2148 Sugar transferases involved in lipopolysaccharide synthesis
HKFIFLAF_01190 2.9e-149 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
HKFIFLAF_01191 2.1e-137 ywqE 3.1.3.48 GM COG4464 Capsular polysaccharide biosynthesis protein
HKFIFLAF_01192 1e-109 ywqD 2.7.10.1 D COG0489 ATPases involved in chromosome partitioning
HKFIFLAF_01193 2.4e-117 ywqC M biosynthesis protein
HKFIFLAF_01194 1.2e-143 E lipolytic protein G-D-S-L family
HKFIFLAF_01195 1.6e-95 sigS 2.7.7.6 K Belongs to the sigma-70 factor family. ECF subfamily
HKFIFLAF_01196 2.5e-88 K ComK protein
HKFIFLAF_01198 3.5e-09 csbD S Belongs to the UPF0337 (CsbD) family
HKFIFLAF_01200 0.0 metH 2.1.1.13 E Methionine synthase
HKFIFLAF_01201 8.6e-159 yitJ 1.5.1.20, 2.1.1.10, 2.1.1.13 E Catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine
HKFIFLAF_01202 1.1e-173 yitJ 1.5.1.20, 2.1.1.10, 2.1.1.13 E Catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine
HKFIFLAF_01204 1.9e-151 msrR K COG1316 Transcriptional regulator
HKFIFLAF_01205 5.3e-99 yngC S membrane-associated protein
HKFIFLAF_01206 5e-232 S SNARE associated Golgi protein
HKFIFLAF_01207 3.3e-55 yodB K transcriptional
HKFIFLAF_01208 1.5e-192 S Protein of unknown function (DUF1648)
HKFIFLAF_01209 6.5e-69 K helix_turn_helix gluconate operon transcriptional repressor
HKFIFLAF_01210 4.8e-115 glnP P ABC transporter
HKFIFLAF_01211 6.1e-109 gluC P ABC transporter
HKFIFLAF_01212 2.1e-135 glnH ET Belongs to the bacterial solute-binding protein 3 family
HKFIFLAF_01213 3.4e-132 glnQ 3.6.3.21 E COG1126 ABC-type polar amino acid transport system, ATPase component
HKFIFLAF_01214 1.2e-172 ydbI S AI-2E family transporter
HKFIFLAF_01215 3e-24 tatA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
HKFIFLAF_01216 8e-146 uppP 3.6.1.27 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
HKFIFLAF_01217 0.0 ydaO E amino acid
HKFIFLAF_01218 1.5e-277 glyQS 6.1.1.14 J Catalyzes the attachment of glycine to tRNA(Gly)
HKFIFLAF_01219 8.5e-190 T HD domain
HKFIFLAF_01221 1.4e-214 yqiG C COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family
HKFIFLAF_01222 4e-90 S Belongs to the UPF0312 family
HKFIFLAF_01223 1.6e-65 ric D Di-iron-containing protein involved in the repair of iron-sulfur clusters
HKFIFLAF_01225 6.2e-32
HKFIFLAF_01226 1e-142 ypmR1 E G-D-S-L family
HKFIFLAF_01227 1.1e-169 bcrA V ABC transporter, ATP-binding protein
HKFIFLAF_01228 4.8e-174 bcrB S ABC transporter (permease)
HKFIFLAF_01229 6.4e-88
HKFIFLAF_01230 3.3e-95 1.5.1.38 S FMN reductase
HKFIFLAF_01232 1.6e-145 pflA 1.97.1.4 C Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HKFIFLAF_01233 0.0 pflB 2.3.1.54 C formate acetyltransferase
HKFIFLAF_01236 1.2e-149 focA P Formate/nitrite transporter
HKFIFLAF_01237 2.8e-138 L Archaeal putative transposase ISC1217
HKFIFLAF_01238 1.8e-34 L DDE superfamily endonuclease
HKFIFLAF_01240 3.6e-164 L COG3547 Transposase and inactivated derivatives
HKFIFLAF_01241 2.5e-20 C 4Fe-4S single cluster domain
HKFIFLAF_01242 4e-71 C radical SAM
HKFIFLAF_01243 1e-50 6.1.1.12 J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
HKFIFLAF_01245 7.7e-81 P PFAM major facilitator superfamily MFS_1
HKFIFLAF_01246 6.9e-37 E aminopeptidase activity
HKFIFLAF_01247 1.1e-31 3.4.11.2 E peptide catabolic process
HKFIFLAF_01248 7.4e-60 I radical SAM domain protein
HKFIFLAF_01249 3.2e-86 L Reverse transcriptase
HKFIFLAF_01250 2.4e-181 L Mu transposase, C-terminal
HKFIFLAF_01252 2.9e-08 L Reverse transcriptase
HKFIFLAF_01253 1.3e-131 tcyC 3.6.3.21 E COG1126 ABC-type polar amino acid transport system, ATPase component
HKFIFLAF_01254 3.2e-116 tcyB P COG0765 ABC-type amino acid transport system, permease component
HKFIFLAF_01255 5.1e-142 tcyA ET Belongs to the bacterial solute-binding protein 3 family
HKFIFLAF_01256 2.9e-167 pip 3.4.11.5, 3.5.1.101 S Releases the N-terminal proline from various substrates
HKFIFLAF_01257 1.1e-83 S Rubrerythrin
HKFIFLAF_01258 1.5e-164 ppaC 3.6.1.1 C Inorganic pyrophosphatase
HKFIFLAF_01259 3.7e-103 yvbG U UPF0056 membrane protein
HKFIFLAF_01260 1.2e-221 queG 1.17.99.6 C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HKFIFLAF_01261 3.2e-161 yhbB S Putative amidase domain
HKFIFLAF_01262 2e-88 trmL 2.1.1.207 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
HKFIFLAF_01263 0.0 prkA T Ser protein kinase
HKFIFLAF_01264 9.6e-222 yhbH S Belongs to the UPF0229 family
HKFIFLAF_01266 2.5e-98 2.3.1.128 J Acetyltransferase (GNAT) domain
HKFIFLAF_01267 8.1e-177 pit P phosphate transporter
HKFIFLAF_01268 5.6e-112 ykaA P COG1392 Phosphate transport regulator (distant homolog of PhoU)
HKFIFLAF_01269 2.7e-77 rlmH 2.1.1.177 J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HKFIFLAF_01270 1.2e-182 htrA 3.4.21.107 O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HKFIFLAF_01271 1.3e-145 vicX 3.1.26.11 S COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I
HKFIFLAF_01272 2.3e-139 yycI S protein conserved in bacteria
HKFIFLAF_01273 4.1e-242 yycH S protein conserved in bacteria
HKFIFLAF_01274 0.0 vicK 2.7.13.3 T Histidine kinase
HKFIFLAF_01275 8.7e-133 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HKFIFLAF_01279 3.6e-246 purA 6.3.4.4 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HKFIFLAF_01280 2.2e-249 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
HKFIFLAF_01281 1.2e-71 rplI J binds to the 23S rRNA
HKFIFLAF_01282 0.0 yybT T signaling protein consisting of a modified GGDEF domain and a DHH domain
HKFIFLAF_01283 6.7e-157 yybS S membrane
HKFIFLAF_01284 3e-37 rpsR J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HKFIFLAF_01285 3.2e-81 ssb L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
HKFIFLAF_01286 5e-47 rpsF J Binds together with S18 to 16S ribosomal RNA
HKFIFLAF_01287 1.6e-79 ribH 2.5.1.78 H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
HKFIFLAF_01288 1.5e-222 ribBA 3.5.4.25, 4.1.99.12 H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HKFIFLAF_01289 1.6e-117 ribE 2.5.1.9 H Riboflavin synthase
HKFIFLAF_01290 6.8e-209 ribD 1.1.1.193, 3.5.4.26 H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HKFIFLAF_01291 1e-204 ychF J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
HKFIFLAF_01292 1.1e-32 yyzM S protein conserved in bacteria
HKFIFLAF_01293 2e-150 ykuT M Mechanosensitive ion channel
HKFIFLAF_01294 1.3e-113 yyaC S Sporulation protein YyaC
HKFIFLAF_01295 5.5e-119 ydfK S Protein of unknown function (DUF554)
HKFIFLAF_01296 3.8e-151 spo0J K Belongs to the ParB family
HKFIFLAF_01297 6.9e-136 soj D COG1192 ATPases involved in chromosome partitioning
HKFIFLAF_01298 9.1e-153 noc D Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage
HKFIFLAF_01299 8.7e-133 rsmG 2.1.1.170 J Specifically methylates the N7 position of guanine in position 535 of 16S rRNA
HKFIFLAF_01300 0.0 gidA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
HKFIFLAF_01301 6.9e-251 mnmE S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HKFIFLAF_01302 4.5e-109 jag S single-stranded nucleic acid binding R3H
HKFIFLAF_01303 3.2e-128 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HKFIFLAF_01304 4.2e-56 rnpA 3.1.26.5 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
HKFIFLAF_01305 9e-256 dnaA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HKFIFLAF_01306 1.6e-208 dnaN 2.7.7.7 L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
HKFIFLAF_01307 2.4e-33 yaaA S S4 domain
HKFIFLAF_01308 3.5e-205 recF L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HKFIFLAF_01309 6.2e-10 yaaB S Domain of unknown function (DUF370)
HKFIFLAF_01310 0.0 gyrB 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HKFIFLAF_01311 0.0 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HKFIFLAF_01312 2.6e-197 M1-161 T HD domain
HKFIFLAF_01313 8.8e-90 sipT 3.4.21.89 U Belongs to the peptidase S26 family
HKFIFLAF_01314 4.1e-198 yrpB 1.13.12.16 S COG2070 Dioxygenases related to 2-nitropropane dioxygenase
HKFIFLAF_01315 1.4e-35 XK27_04860 K Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HKFIFLAF_01318 1.6e-55 E Glyoxalase
HKFIFLAF_01319 0.0 ppdK 2.7.3.13, 2.7.9.1 G Belongs to the PEP-utilizing enzyme family
HKFIFLAF_01320 1.1e-147 yqfL 2.7.11.33, 2.7.4.28 S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation
HKFIFLAF_01321 8.2e-45 yjjL G Major facilitator superfamily
HKFIFLAF_01322 6.3e-145
HKFIFLAF_01323 0.0 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HKFIFLAF_01324 0.0 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HKFIFLAF_01325 1.9e-71 yccU S CoA-binding protein
HKFIFLAF_01326 2.2e-97 plsY 2.3.1.15, 3.5.1.104 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
HKFIFLAF_01327 3.7e-53 yneR S Belongs to the HesB IscA family
HKFIFLAF_01328 1.1e-52 yneQ
HKFIFLAF_01329 2.9e-75 yneP S thioesterase
HKFIFLAF_01330 4.1e-31 tlp S Belongs to the Tlp family
HKFIFLAF_01331 1.9e-18 sspN S Small acid-soluble spore protein N family
HKFIFLAF_01333 0.0 acnA 4.2.1.3 C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HKFIFLAF_01334 9.2e-239 pepS E COG2309 Leucyl aminopeptidase (aminopeptidase T)
HKFIFLAF_01335 2.6e-39
HKFIFLAF_01336 8.6e-19 sspP S Belongs to the SspP family
HKFIFLAF_01337 1.4e-08 S membrane
HKFIFLAF_01338 8.6e-113 M lytic transglycosylase activity
HKFIFLAF_01339 0.0 alkK IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
HKFIFLAF_01340 1.1e-111 M effector of murein hydrolase
HKFIFLAF_01341 7.6e-62 S Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein. When a cell is stressed by the addition of antibiotics or by other factors in the environment, CidA possibly oligomerizes within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are also hypothesized to regulate the subsequent cell lysis by either allowing the murein hydrolases access to the cell wall substrate and or regulating their activity by a
HKFIFLAF_01342 3.2e-43 S Small, acid-soluble spore proteins, alpha/beta type
HKFIFLAF_01343 0.0 yheH V COG1132 ABC-type multidrug transport system, ATPase and permease components
HKFIFLAF_01344 0.0 yheI V COG1132 ABC-type multidrug transport system, ATPase and permease components
HKFIFLAF_01345 8.5e-48 iscA S Heme biosynthesis protein HemY
HKFIFLAF_01346 3e-235 ywoD EGP Major facilitator superfamily
HKFIFLAF_01347 4.5e-197 yetN S Protein of unknown function (DUF3900)
HKFIFLAF_01348 3.6e-231 yifK E COG1113 Gamma-aminobutyrate permease and related permeases
HKFIFLAF_01349 1.4e-15
HKFIFLAF_01350 3.3e-189 yxaB GM Polysaccharide pyruvyl transferase
HKFIFLAF_01351 7.4e-129 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HKFIFLAF_01352 1.1e-184 bceS 2.7.13.3 T Signal transduction histidine kinase
HKFIFLAF_01353 4e-136 bceA V ABC transporter, ATP-binding protein
HKFIFLAF_01354 0.0 bceB V ABC transporter (permease)
HKFIFLAF_01355 5.2e-47 yxiS
HKFIFLAF_01356 1.6e-45 S Protein of unknown function (DUF1292)
HKFIFLAF_01357 2.2e-176 trxB_2 1.8.1.9 C FAD dependent oxidoreductase
HKFIFLAF_01358 1.3e-119 folE 3.5.4.16 H GTP cyclohydrolase
HKFIFLAF_01359 3.6e-48 ykvR S Protein of unknown function (DUF3219)
HKFIFLAF_01360 4.4e-175 yceB C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKFIFLAF_01362 3.4e-236 mvaA 1.1.1.34, 1.1.1.88, 2.3.1.9 I Hydroxymethylglutaryl-coenzyme A reductase
HKFIFLAF_01363 3.3e-222 mvaS 2.3.3.10 I synthase
HKFIFLAF_01364 1e-207 atoB 1.1.1.88, 2.3.1.9 I Belongs to the thiolase family
HKFIFLAF_01365 4.2e-53 S DsrE/DsrF-like family
HKFIFLAF_01366 8.5e-73
HKFIFLAF_01367 4.2e-178 ghrB 1.1.1.215, 1.1.1.26, 1.1.1.43, 1.1.1.79, 1.1.1.81 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HKFIFLAF_01369 1.4e-178 proV E COG1125 ABC-type proline glycine betaine transport systems, ATPase components
HKFIFLAF_01370 8.6e-271 proWX EM COG1174 ABC-type proline glycine betaine transport systems, permease component
HKFIFLAF_01372 0.0 treC 3.2.1.93 GH13 G COG0366 Glycosidases
HKFIFLAF_01373 2.8e-131 treR K transcriptional
HKFIFLAF_01374 4.2e-32 S PFAM Uncharacterised protein family UPF0236
HKFIFLAF_01375 1e-17 S PFAM Uncharacterised protein family UPF0236
HKFIFLAF_01376 7.7e-82 fld C Flavodoxin
HKFIFLAF_01377 9.8e-74 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
HKFIFLAF_01378 3.1e-41 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
HKFIFLAF_01379 8.9e-136 4.1.99.16, 4.2.3.22, 4.2.3.75 T COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
HKFIFLAF_01380 0.0 3.6.3.3, 3.6.3.5 P E1-E2 ATPase
HKFIFLAF_01381 1.3e-29 P Heavy-metal-associated domain
HKFIFLAF_01383 0.0 nrdA 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HKFIFLAF_01384 5.6e-88 fld C Flavodoxin
HKFIFLAF_01385 1.9e-192 nrdB 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HKFIFLAF_01386 9.6e-104 plsY 2.3.1.15 I Belongs to the PlsY family
HKFIFLAF_01387 1.2e-202 crtQ M Glycosyl transferase family 21
HKFIFLAF_01388 2.6e-18 S transposase or invertase
HKFIFLAF_01389 5.2e-92 Q Thioesterase superfamily
HKFIFLAF_01390 5e-48 sugE P Multidrug resistance protein
HKFIFLAF_01391 4.7e-52 ykkC P Multidrug resistance protein
HKFIFLAF_01392 9.2e-136 yfcA S membrane transporter protein
HKFIFLAF_01393 1.9e-173 fhuG P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKFIFLAF_01394 2.8e-180 fhuB P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKFIFLAF_01395 5.8e-172 fhuD P Periplasmic binding protein
HKFIFLAF_01396 1.1e-150 fhuC 3.6.3.34 HP ABC transporter
HKFIFLAF_01397 7.2e-197 ycgT 1.18.1.2, 1.19.1.1 C Ferredoxin--NADP reductase
HKFIFLAF_01398 1.6e-92
HKFIFLAF_01399 5.3e-101
HKFIFLAF_01400 1.2e-126 yeeN K transcriptional regulatory protein
HKFIFLAF_01401 2.1e-188 T Anti-anti-sigma regulatory factor (Antagonist of anti-sigma factor)
HKFIFLAF_01402 8.5e-62 isp O Subtilase family
HKFIFLAF_01403 1.1e-66 L Transposase, IS4 family protein
HKFIFLAF_01404 3e-65 L Transposase, IS4 family protein
HKFIFLAF_01405 5.6e-27 L Transposase, IS4 family protein
HKFIFLAF_01406 3.8e-51 L Transposase, IS4 family protein
HKFIFLAF_01407 4.5e-272 EGP Major facilitator Superfamily
HKFIFLAF_01408 3.7e-232 pepT 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
HKFIFLAF_01409 4.5e-154 M Glycosyl transferase family 8
HKFIFLAF_01410 7.7e-239 yisQ V Mate efflux family protein
HKFIFLAF_01411 1.8e-220 pilM NU Pilus assembly protein
HKFIFLAF_01412 3.7e-94
HKFIFLAF_01413 4.7e-140 modF 3.6.3.21, 3.6.3.34 P COG1119 ABC-type molybdenum transport system, ATPase component photorepair protein PhrA
HKFIFLAF_01414 3.3e-189 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HKFIFLAF_01415 2.9e-98 metI P COG2011 ABC-type metal ion transport system, permease component
HKFIFLAF_01416 4.7e-154 metQ M Belongs to the nlpA lipoprotein family
HKFIFLAF_01417 0.0 cstA T Carbon starvation protein
HKFIFLAF_01418 1.6e-207 ilvE 2.6.1.42 E Branched-chain amino acid aminotransferase
HKFIFLAF_01419 3e-128 thrE S Putative threonine/serine exporter
HKFIFLAF_01420 1.8e-72 S Threonine/Serine exporter, ThrE
HKFIFLAF_01421 1e-126 S Protein of unknown function (DUF1646)
HKFIFLAF_01422 0.0 asnO 6.3.5.4 E Asparagine synthase
HKFIFLAF_01423 9.9e-177 ywbI K Transcriptional regulator
HKFIFLAF_01424 6e-56 ywbH S LrgA family
HKFIFLAF_01425 1.3e-117 ywbG M effector of murein hydrolase
HKFIFLAF_01427 3.3e-115 ybaK S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HKFIFLAF_01428 1.4e-77
HKFIFLAF_01429 4.4e-126 T Two component transcriptional regulator, winged helix family
HKFIFLAF_01430 4.2e-231 T His Kinase A (phosphoacceptor) domain
HKFIFLAF_01431 7.7e-14
HKFIFLAF_01432 4.6e-160 S Alpha/beta hydrolase of unknown function (DUF915)
HKFIFLAF_01433 2.2e-151 ybbH_2 K Transcriptional regulator
HKFIFLAF_01434 6.8e-229 phoA 3.1.3.1 P Belongs to the alkaline phosphatase family
HKFIFLAF_01435 0.0 recQ 3.6.4.12 L DNA helicase
HKFIFLAF_01436 9.8e-163 ycsE S hydrolases of the HAD superfamily
HKFIFLAF_01437 1.1e-129 bshB2 S deacetylase
HKFIFLAF_01438 5.7e-61 yojF S Protein of unknown function (DUF1806)
HKFIFLAF_01439 5.8e-149 thiD 2.5.1.3, 2.7.1.35, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Phosphomethylpyrimidine kinase
HKFIFLAF_01441 1.2e-109 V ATPases associated with a variety of cellular activities
HKFIFLAF_01442 2.7e-54 3.5.1.19 Q Isochorismatase family
HKFIFLAF_01443 4.7e-146 S Protein of unknown function
HKFIFLAF_01444 1.5e-141 IQ Enoyl-(Acyl carrier protein) reductase
HKFIFLAF_01445 1.3e-112 EGP Major facilitator Superfamily
HKFIFLAF_01446 3.1e-26 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
HKFIFLAF_01447 2.7e-40 S Protein of unknown function (DUF2750)
HKFIFLAF_01448 1.3e-84 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HKFIFLAF_01450 7.7e-191 adhP 1.1.1.1 C alcohol dehydrogenase
HKFIFLAF_01451 1.8e-41 S Nucleotidyltransferase domain
HKFIFLAF_01452 4e-35 S Protein of unknown function DUF86
HKFIFLAF_01453 2.4e-206 yurR 1.4.5.1 E COG0665 Glycine D-amino acid oxidases (deaminating)
HKFIFLAF_01454 8.5e-113 crtF 2.1.1.210, 2.1.1.281, 2.1.1.79 M Methyltransferase
HKFIFLAF_01455 2.3e-63
HKFIFLAF_01456 1.5e-91 E Zn peptidase
HKFIFLAF_01457 3.6e-29
HKFIFLAF_01458 1.1e-15 hsdM 2.1.1.72 V Type I restriction-modification
HKFIFLAF_01460 3.5e-92 S Psort location CytoplasmicMembrane, score
HKFIFLAF_01461 1.2e-55 I Domain of unknown function (DUF4430)
HKFIFLAF_01462 4.8e-188 M FFAT motif binding
HKFIFLAF_01463 0.0 htpG O Molecular chaperone. Has ATPase activity
HKFIFLAF_01464 1.3e-213 hipO3 3.5.1.47 S amidohydrolase
HKFIFLAF_01465 7.9e-132 artP ET COG0834 ABC-type amino acid transport signal transduction systems, periplasmic component domain
HKFIFLAF_01466 6.4e-114 artQ E COG0765 ABC-type amino acid transport system, permease component
HKFIFLAF_01467 8.3e-131 artM 3.6.3.21 E COG1126 ABC-type polar amino acid transport system, ATPase component
HKFIFLAF_01468 1.5e-77 ymaD O redox protein, regulator of disulfide bond formation
HKFIFLAF_01469 4.6e-211 EGP Major facilitator Superfamily
HKFIFLAF_01470 1.9e-132 kipI 3.5.1.54 E Allophanate hydrolase subunit 1
HKFIFLAF_01471 4.4e-183 kipA 6.3.4.6 E Allophanate hydrolase subunit 2
HKFIFLAF_01472 1.4e-136 ycsF S Belongs to the UPF0271 (lamB) family
HKFIFLAF_01473 7.6e-118 S Protein of unknown function (DUF969)
HKFIFLAF_01474 4.2e-167 S Protein of unknown function (DUF979)
HKFIFLAF_01475 6.7e-116 pcp 3.4.19.3 O Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HKFIFLAF_01476 2.3e-224 pbuO_1 S permease
HKFIFLAF_01477 1.6e-17
HKFIFLAF_01478 3.7e-44 S Leucine-rich repeat (LRR) protein
HKFIFLAF_01479 3.5e-225 uraA F Xanthine uracil
HKFIFLAF_01480 0.0 poxB 1.2.3.3, 1.2.5.1 EH Belongs to the TPP enzyme family
HKFIFLAF_01481 1.5e-124 deoC 4.1.2.4 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HKFIFLAF_01482 4.5e-300 msbA2 3.6.3.44 V ABC transporter
HKFIFLAF_01483 1.6e-109 yhhQ_2 S Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HKFIFLAF_01484 1.9e-97 queF 1.7.1.13 S Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HKFIFLAF_01485 0.0 S MMPL domain protein
HKFIFLAF_01486 1.9e-291 amy 3.2.1.1 GH13 G Belongs to the glycosyl hydrolase 13 family
HKFIFLAF_01487 2.4e-43 xfp 4.1.2.22, 4.1.2.9 G D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase
HKFIFLAF_01488 7.8e-146 T COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
HKFIFLAF_01489 1.4e-107 fliY ET Belongs to the bacterial solute-binding protein 3 family
HKFIFLAF_01490 1.5e-91 artQ_1 E amino acid transport system, permease
HKFIFLAF_01491 9.4e-106 glnQ2 3.6.3.21 E COG1126 ABC-type polar amino acid transport system, ATPase component
HKFIFLAF_01492 8.9e-239 LYS1 1.5.1.7 E Saccharopine dehydrogenase
HKFIFLAF_01493 1.2e-224 nspC 4.1.1.96 E Pyridoxal-dependent decarboxylase, C-terminal sheet domain
HKFIFLAF_01494 5.6e-208 S Domain of unknown function (DUF1611_N) Rossmann-like domain
HKFIFLAF_01495 8.7e-215 5.1.1.12 E Alanine racemase, N-terminal domain
HKFIFLAF_01496 1.1e-137 cjaA ET Belongs to the bacterial solute-binding protein 3 family
HKFIFLAF_01497 1.6e-129 glnQ 3.6.3.21 E ATPases associated with a variety of cellular activities
HKFIFLAF_01498 1.4e-103 E amino acid ABC transporter
HKFIFLAF_01499 3.4e-115 papP E amino acid ABC transporter
HKFIFLAF_01500 1.7e-292 mqo 1.1.5.4 S malate quinone oxidoreductase
HKFIFLAF_01501 2.3e-243 kgtP EGP -transporter
HKFIFLAF_01502 5.2e-167 yvfR V COG1131 ABC-type multidrug transport system, ATPase component
HKFIFLAF_01503 2.7e-137 yvfS V COG0842 ABC-type multidrug transport system, permease component
HKFIFLAF_01504 4.3e-206 desK 2.7.13.3 T Histidine kinase
HKFIFLAF_01505 1.1e-104 desR T COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HKFIFLAF_01506 2.8e-94 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HKFIFLAF_01507 1.1e-103 yisN S Protein of unknown function (DUF2777)
HKFIFLAF_01508 2.5e-59 yisL S UPF0344 protein
HKFIFLAF_01509 2.3e-167 yisK Q COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)
HKFIFLAF_01510 4.6e-224 P Protein of unknown function (DUF418)
HKFIFLAF_01511 8.7e-31 gerPA S Spore germination protein
HKFIFLAF_01512 1.4e-97 gerPC S Spore germination protein
HKFIFLAF_01513 2e-25 gerPD S Spore germination protein
HKFIFLAF_01514 4.9e-70 gerPE S Spore germination protein GerPE
HKFIFLAF_01515 4.7e-29 gerPF S Spore germination protein gerPA/gerPF
HKFIFLAF_01516 0.0 addA 3.6.4.12 L ATP-dependent helicase nuclease subunit A
HKFIFLAF_01517 0.0 addB 3.1.21.3, 3.6.4.12 L ATP-dependent helicase deoxyribonuclease subunit B
HKFIFLAF_01518 1.9e-144 S Mitochondrial biogenesis AIM24
HKFIFLAF_01519 1.7e-96 comK K Competence transcription factor
HKFIFLAF_01520 1.7e-08 S IDEAL
HKFIFLAF_01521 3.9e-213 yhfN 3.4.24.84 O Peptidase M48
HKFIFLAF_01522 1.5e-41 azlD S branched-chain amino acid
HKFIFLAF_01523 7.2e-119 azlC E AzlC protein
HKFIFLAF_01524 1.5e-294 fadD 6.2.1.3 IQ Activates fatty acids by binding to coenzyme A
HKFIFLAF_01525 9.4e-186 lplJ 6.3.1.20 H Lipoate-protein ligase
HKFIFLAF_01526 3e-21 yhfH S YhfH-like protein
HKFIFLAF_01527 2.3e-63 ytkA S YtkA-like
HKFIFLAF_01528 4.3e-103 ypmQ S protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems
HKFIFLAF_01529 7.3e-65 aldA 1.2.1.21, 1.2.1.22 C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
HKFIFLAF_01530 7.1e-162 EG EamA-like transporter family
HKFIFLAF_01531 3.3e-71 EGP Major facilitator Superfamily
HKFIFLAF_01532 3.1e-14 ydjF K DeoR C terminal sensor domain
HKFIFLAF_01533 6.1e-187 yhgE S YhgE Pip N-terminal domain protein
HKFIFLAF_01534 1.2e-100 yhgD K Transcriptional regulator
HKFIFLAF_01535 2.6e-269 hemG 1.14.19.9, 1.3.3.15, 1.3.3.4 H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HKFIFLAF_01536 1.2e-182 hemH 4.99.1.1, 4.99.1.9 H Catalyzes the ferrous insertion into protoporphyrin IX
HKFIFLAF_01537 2.7e-199 hemE 4.1.1.37 H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HKFIFLAF_01538 1.4e-95 traP 1.14.99.57 S enzyme involved in biosynthesis of extracellular polysaccharides
HKFIFLAF_01539 2.7e-239 yhfA C membrane
HKFIFLAF_01540 4.4e-230 yhaA 3.5.1.47 E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
HKFIFLAF_01541 2.5e-220 ecsB U ABC transporter
HKFIFLAF_01542 2.5e-138 ecsA V transporter (ATP-binding protein)
HKFIFLAF_01543 6.3e-75 hit FG COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
HKFIFLAF_01544 6.5e-85 trpP S Tryptophan transporter TrpP
HKFIFLAF_01545 1.6e-18 yhaH S YtxH-like protein
HKFIFLAF_01546 1.5e-103 hpr K Negative regulator of protease production and sporulation
HKFIFLAF_01547 3.7e-54 yhaI S Protein of unknown function (DUF1878)
HKFIFLAF_01549 9.6e-150 prsA 5.2.1.8 M plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins
HKFIFLAF_01550 3e-27 yhaL S Sporulation protein YhaL
HKFIFLAF_01551 1.1e-178 yhaM L Shows a 3'-5' exoribonuclease activity
HKFIFLAF_01552 0.0 L AAA domain
HKFIFLAF_01553 1e-248 yhaO L DNA repair exonuclease
HKFIFLAF_01554 6.9e-153 ycgQ S membrane
HKFIFLAF_01555 6.1e-152 ycgR S permeases
HKFIFLAF_01557 6.7e-123 P Integral membrane protein TerC family
HKFIFLAF_01558 1.7e-27 S YhzD-like protein
HKFIFLAF_01559 3.4e-138 yhaR 5.3.3.18 I enoyl-CoA hydratase
HKFIFLAF_01560 1.3e-159 yhaX S hydrolases of the HAD superfamily
HKFIFLAF_01561 6.1e-55 yheA S Belongs to the UPF0342 family
HKFIFLAF_01562 4e-204 yheB S Belongs to the UPF0754 family
HKFIFLAF_01563 7.8e-260 gshB 6.3.2.2, 6.3.2.3 HJ YheC/D like ATP-grasp
HKFIFLAF_01564 4.9e-212 yheC HJ YheC/D like ATP-grasp
HKFIFLAF_01565 3.6e-11 yheC HJ YheC/D like ATP-grasp
HKFIFLAF_01566 7.2e-269 gshB 6.3.2.2, 6.3.2.3 HJ YheC/D like ATP-grasp
HKFIFLAF_01567 4.8e-229 HJ COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase)
HKFIFLAF_01568 1.1e-169 lrp QT PucR C-terminal helix-turn-helix domain
HKFIFLAF_01569 3.8e-204 msmK P Belongs to the ABC transporter superfamily
HKFIFLAF_01570 3.4e-29 sspB S spore protein
HKFIFLAF_01571 1.6e-263 fumC 1.1.1.38, 4.2.1.2 C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
HKFIFLAF_01572 1.2e-17 S transposase or invertase
HKFIFLAF_01573 1.9e-16 S transposase or invertase
HKFIFLAF_01574 2.9e-144 S transposase or invertase
HKFIFLAF_01576 8.3e-105 clpP 3.4.21.92 OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
HKFIFLAF_01577 4.3e-40 crh G Phosphocarrier protein Chr
HKFIFLAF_01578 4e-173 whiA K May be required for sporulation
HKFIFLAF_01579 3.4e-180 ybhK S Required for morphogenesis under gluconeogenic growth conditions
HKFIFLAF_01580 1.8e-167 rapZ S Displays ATPase and GTPase activities
HKFIFLAF_01581 3e-86 yvcI 3.6.1.55 F Nudix hydrolase
HKFIFLAF_01582 3.1e-178 trxB 1.8.1.9 C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
HKFIFLAF_01583 2.7e-253 S COG0457 FOG TPR repeat
HKFIFLAF_01584 1.6e-72 yvoF S COG0110 Acetyltransferase (isoleucine patch superfamily)
HKFIFLAF_01585 2.8e-117 ppaX 3.1.3.18, 3.6.1.1 S Hydrolyzes pyrophosphate formed during P-Ser-HPr dephosphorylation by HPrK P. Might play a role in controlling the intracellular pyrophosphate pool
HKFIFLAF_01586 3.5e-154 lgt 2.1.1.199 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HKFIFLAF_01587 2.7e-174 hprK F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HKFIFLAF_01588 4.9e-33 yvlD S Membrane
HKFIFLAF_01589 2.4e-169 yvlB S Putative adhesin
HKFIFLAF_01590 0.0 2.7.8.12 M CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
HKFIFLAF_01591 4.5e-146 tagG GM Transport permease protein
HKFIFLAF_01592 5.2e-231 tagF 2.7.8.12 M glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HKFIFLAF_01593 4.2e-183 tagB 2.7.8.14, 2.7.8.44, 2.7.8.47 M glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HKFIFLAF_01594 3.7e-19 tagD 2.7.7.15, 2.7.7.39 IM Cytidylyltransferase
HKFIFLAF_01595 4.2e-164 M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HKFIFLAF_01596 3.6e-145 ykoT GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
HKFIFLAF_01597 1.8e-223 tagB 2.7.8.14, 2.7.8.44, 2.7.8.47 M glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HKFIFLAF_01598 2.8e-72 tagD 2.7.7.15, 2.7.7.39 IM Cytidylyltransferase
HKFIFLAF_01599 0.0 uvrA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
HKFIFLAF_01600 0.0 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
HKFIFLAF_01601 5.5e-10 S Uncharacterized conserved protein (DUF2164)
HKFIFLAF_01602 2.4e-34 csbA S protein conserved in bacteria
HKFIFLAF_01603 1.4e-118 yfbR S HD containing hydrolase-like enzyme
HKFIFLAF_01604 1.5e-50 S EamA-like transporter family
HKFIFLAF_01605 3.3e-56 P EamA-like transporter family
HKFIFLAF_01606 0.0
HKFIFLAF_01607 3.9e-173 M Glycosyltransferase like family 2
HKFIFLAF_01608 4.4e-146 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
HKFIFLAF_01609 4.9e-151 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
HKFIFLAF_01610 1.1e-156 pstA P Phosphate transport system permease
HKFIFLAF_01611 4.2e-159 pstC P probably responsible for the translocation of the substrate across the membrane
HKFIFLAF_01612 1.8e-159 pstS P Phosphate
HKFIFLAF_01613 4.5e-258 hemY2 1.3.3.15, 1.3.3.4 H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HKFIFLAF_01614 1.2e-20 phoR 2.7.13.3 T Signal transduction histidine kinase
HKFIFLAF_01615 0.0 phoR 2.7.13.3 T Signal transduction histidine kinase
HKFIFLAF_01616 3.6e-123 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HKFIFLAF_01617 4.1e-48 S Family of unknown function (DUF5316)
HKFIFLAF_01618 2.1e-41 fdxA C 4Fe-4S binding domain
HKFIFLAF_01619 1.6e-174 yclQ P COG4607 ABC-type enterochelin transport system, periplasmic component
HKFIFLAF_01620 6.2e-137 yclP 3.6.3.34 P ABC transporter, ATP-binding protein
HKFIFLAF_01621 9.7e-164 fatC P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKFIFLAF_01622 3e-165 yclN P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKFIFLAF_01623 5.6e-217 minJ O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HKFIFLAF_01625 3.2e-267 ctpB 3.4.21.102 M Belongs to the peptidase S41A family
HKFIFLAF_01626 8.2e-182 1.1.1.3 E homoserine dehydrogenase
HKFIFLAF_01627 1.3e-248 metY 2.5.1.49 E O-acetylhomoserine
HKFIFLAF_01628 2.4e-270 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HKFIFLAF_01629 3.6e-95 D peptidase
HKFIFLAF_01630 4.5e-155 ftsX D Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation
HKFIFLAF_01631 9.3e-124 ftsE D cell division ATP-binding protein FtsE
HKFIFLAF_01632 7.6e-52 cccB C COG2010 Cytochrome c, mono- and diheme variants
HKFIFLAF_01633 1.8e-156 yvjA S Uncharacterized protein conserved in bacteria (DUF2179)
HKFIFLAF_01634 3.2e-170 prfB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HKFIFLAF_01635 0.0 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
HKFIFLAF_01636 1.1e-306 ggtA 2.3.2.2, 3.4.19.13 E gamma-glutamyltransferase
HKFIFLAF_01637 2.3e-96 hpf J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HKFIFLAF_01638 7.9e-55 fliT S bacterial-type flagellum organization
HKFIFLAF_01639 1.1e-68 fliS N flagellar protein FliS
HKFIFLAF_01640 0.0 fliD N morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HKFIFLAF_01641 3e-60 flaG N flagellar protein FlaG
HKFIFLAF_01643 1.8e-107 mpg 3.2.2.21 L Belongs to the DNA glycosylase MPG family
HKFIFLAF_01645 0.0 ycbZ 3.4.21.53 O AAA domain
HKFIFLAF_01647 2.7e-85 fliC N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HKFIFLAF_01648 1.1e-79 secA U SEC-C motif
HKFIFLAF_01649 1.3e-22 S Nucleotidyltransferase domain
HKFIFLAF_01650 1.6e-33 csrA T Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HKFIFLAF_01651 3.6e-76 fliW S Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HKFIFLAF_01652 1.6e-152 flgL N Belongs to the bacterial flagellin family
HKFIFLAF_01653 3.3e-289 flgK N flagellar hook-associated protein
HKFIFLAF_01654 2.2e-68 flgN NOU FlgN protein
HKFIFLAF_01655 1e-38 flgM KNU Negative regulator of flagellin synthesis
HKFIFLAF_01656 6.4e-69 yvyF S flagellar protein
HKFIFLAF_01657 8.6e-133 comFC S Phosphoribosyl transferase domain
HKFIFLAF_01658 2.1e-255 comFA L COG4098 Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HKFIFLAF_01660 3.8e-151 degV S protein conserved in bacteria
HKFIFLAF_01661 1.2e-258 yfnA E amino acid
HKFIFLAF_01662 2.4e-124 degU KT COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HKFIFLAF_01663 4.3e-206 degS 2.7.13.3 T Member of the two-component regulatory system DegS DegU, which plays an important role in the transition growth phase
HKFIFLAF_01664 3.1e-113 yvyE 3.4.13.9 S Domain of unknown function (DUF1949)
HKFIFLAF_01665 3.2e-168 tagO 2.7.8.33, 2.7.8.35 M COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase UDP-N-acetylglucosamine-1-phosphate transferase
HKFIFLAF_01666 0.0 pbpC 3.4.16.4 M Penicillin-binding Protein
HKFIFLAF_01667 1e-231 NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).
HKFIFLAF_01668 9.4e-175 sle1 3.5.1.28 CBM50 M COG1388 FOG LysM repeat
HKFIFLAF_01669 4.3e-124 gntR1 K transcriptional
HKFIFLAF_01670 2.3e-133 nagB 3.1.1.31, 3.5.99.6 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
HKFIFLAF_01671 2.1e-213 nagA 3.5.1.25 G Belongs to the metallo-dependent hydrolases superfamily. NagA family
HKFIFLAF_01672 4e-273 yusP P Major facilitator superfamily
HKFIFLAF_01673 2.8e-176 metAA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HKFIFLAF_01674 3.9e-189 manA 5.3.1.8 G mannose-6-phosphate isomerase
HKFIFLAF_01675 1.5e-70 yaeR E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HKFIFLAF_01676 1.6e-165 cvfB S protein conserved in bacteria
HKFIFLAF_01678 5.7e-14
HKFIFLAF_01679 5.1e-32 S Cold-inducible protein YdjO
HKFIFLAF_01680 4.1e-181 K Transcriptional regulator
HKFIFLAF_01681 1.1e-195 galM 2.7.1.6, 5.1.3.3 G Converts alpha-aldose to the beta-anomer
HKFIFLAF_01682 1.6e-282 galT 2.7.7.12 G UDP-glucose--hexose-1-phosphate uridylyltransferase
HKFIFLAF_01683 2.8e-190 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
HKFIFLAF_01684 3.6e-224 galK 2.7.1.6 G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HKFIFLAF_01685 1.3e-32 K ArsR family transcriptional regulator
HKFIFLAF_01686 1.3e-210 ydbM 1.3.8.1 I acyl-CoA dehydrogenase
HKFIFLAF_01689 1.8e-139 hel M 5'-nucleotidase, lipoprotein e(P4)
HKFIFLAF_01690 3.5e-109 K Bacterial regulatory proteins, tetR family
HKFIFLAF_01691 1.6e-269 EGP Major facilitator Superfamily
HKFIFLAF_01692 2.2e-249 gabP E COG1113 Gamma-aminobutyrate permease and related permeases
HKFIFLAF_01693 6.6e-259 yhxA E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HKFIFLAF_01695 3.6e-79 yjhE S Phage tail protein
HKFIFLAF_01696 2.4e-262 pucI FH Permease for cytosine/purines, uracil, thiamine, allantoin
HKFIFLAF_01697 4.4e-241 allB 3.5.2.5 F Catalyzes the conversion of allantoin (5- ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring
HKFIFLAF_01698 6.5e-85 thiW S Thiamine-precursor transporter protein (ThiW)
HKFIFLAF_01699 4.2e-155 tenA 3.5.99.2 K Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HKFIFLAF_01700 1.6e-90 EGP Transmembrane secretion effector
HKFIFLAF_01702 3.8e-33
HKFIFLAF_01703 7.9e-36 S Membrane
HKFIFLAF_01704 1.6e-91 yjjX F Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HKFIFLAF_01705 4e-206 pepA 3.4.11.7 G COG1363 Cellulase M and related proteins
HKFIFLAF_01706 3.3e-52 ytzB S small secreted protein
HKFIFLAF_01707 5.7e-171 ytnP S COG0491 Zn-dependent hydrolases, including glyoxylases
HKFIFLAF_01708 3.3e-126 trmB 2.1.1.297, 2.1.1.33 J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
HKFIFLAF_01709 2e-58 ytzH S YtzH-like protein
HKFIFLAF_01710 9.9e-154 ytmP 2.7.1.89 M Phosphotransferase
HKFIFLAF_01711 1.5e-137 ytlQ
HKFIFLAF_01712 4.2e-106 ligT 3.1.4.58, 3.5.1.42 J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HKFIFLAF_01714 5.6e-158 dat 2.6.1.21 E Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha- keto acid in the first half-reaction
HKFIFLAF_01715 3.8e-273 pepV 3.5.1.18 E Dipeptidase
HKFIFLAF_01716 2.7e-32 ytzE K COG1349 Transcriptional regulators of sugar metabolism
HKFIFLAF_01717 2e-286 ytgP S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
HKFIFLAF_01718 6.4e-27 yteV S Sporulation protein Cse60
HKFIFLAF_01719 2.3e-10
HKFIFLAF_01721 0.0 leuS 6.1.1.4 J Belongs to the class-I aminoacyl-tRNA synthetase family
HKFIFLAF_01722 1.6e-187 yttB EGP Major facilitator Superfamily
HKFIFLAF_01723 9.4e-43 ytzC S Protein of unknown function (DUF2524)
HKFIFLAF_01725 3.2e-101 ytqB J Putative rRNA methylase
HKFIFLAF_01726 1.3e-207 ytpB 4.2.3.130 S Tetraprenyl-beta-curcumene synthase
HKFIFLAF_01727 1.2e-154 ytpA 3.1.1.5 I Alpha beta hydrolase
HKFIFLAF_01728 5.6e-73 ytoA S COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HKFIFLAF_01729 0.0 asnB 6.3.5.4 E Asparagine synthase
HKFIFLAF_01730 3.2e-220 metK 2.5.1.6 H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HKFIFLAF_01731 1.8e-308 pckA 4.1.1.49 C Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HKFIFLAF_01732 2e-67 3.6.1.55 F GDP-mannose mannosyl hydrolase activity
HKFIFLAF_01733 1.1e-15 S Ribbon-helix-helix protein, copG family
HKFIFLAF_01735 4e-83 ydiB 2.7.1.221, 5.1.1.1 S ATPase or kinase
HKFIFLAF_01736 2.8e-128 yeaZ 2.3.1.234 O COG1214 Inactive homolog of metal-dependent proteases
HKFIFLAF_01737 2.2e-81 rimI 2.3.1.128 K This enzyme acetylates the N-terminal alanine of ribosomal protein S18
HKFIFLAF_01738 8.1e-185 tsaD 2.3.1.234 O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HKFIFLAF_01739 0.0 ydiF S ABC transporter
HKFIFLAF_01740 1.1e-09 rex K Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HKFIFLAF_01741 4.6e-123 rex K Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HKFIFLAF_01742 1.5e-130 tatC U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HKFIFLAF_01743 4.7e-28 S Domain of unknown function (DUF4305)
HKFIFLAF_01744 2.9e-123 ydiL S CAAX protease self-immunity
HKFIFLAF_01745 5.7e-43 groS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HKFIFLAF_01746 4.5e-286 groL O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
HKFIFLAF_01747 4.1e-68 yngA S GtrA-like protein
HKFIFLAF_01748 6.6e-187 ykoT GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
HKFIFLAF_01749 0.0 ykoS
HKFIFLAF_01750 4.7e-199 ykfB 5.1.1.20 M Belongs to the mandelate racemase muconate lactonizing enzyme family
HKFIFLAF_01751 2.4e-106 pncA Q COG1335 Amidases related to nicotinamidase
HKFIFLAF_01752 4.7e-282 pncB 6.3.4.21 H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HKFIFLAF_01753 2e-152 nadE 6.3.1.5 H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
HKFIFLAF_01754 2.4e-305 guaA 2.3.1.128, 6.3.5.2 F Catalyzes the synthesis of GMP from XMP
HKFIFLAF_01755 7.7e-31 S Domain of unknown function (DUF4177)
HKFIFLAF_01756 4.7e-31
HKFIFLAF_01757 1.4e-27 K Helix-turn-helix domain
HKFIFLAF_01758 8.8e-63 EGP Major facilitator Superfamily
HKFIFLAF_01759 8.7e-148 emrB P Major facilitator superfamily
HKFIFLAF_01761 3.1e-93
HKFIFLAF_01762 7.4e-138 scrR K helix_turn _helix lactose operon repressor
HKFIFLAF_01763 4.8e-202 scrB 3.2.1.26 GH32 G invertase
HKFIFLAF_01764 7.6e-280 scrA 2.7.1.211, 5.3.1.1 G pts system
HKFIFLAF_01766 2.8e-227 ywdJ F Xanthine uracil
HKFIFLAF_01767 0.0 yjcD 3.6.4.12 L DNA helicase
HKFIFLAF_01768 8.9e-29 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HKFIFLAF_01769 7.2e-98 O HI0933-like protein
HKFIFLAF_01770 1.8e-80 K Acetyltransferase (GNAT) domain
HKFIFLAF_01771 8.1e-232 rocD 2.6.1.11, 2.6.1.13, 2.6.1.17 E Catalyzes the interconversion of ornithine to glutamate semialdehyde
HKFIFLAF_01772 9.3e-245 rocR KT COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains
HKFIFLAF_01773 8e-162 hsdS 3.1.21.3 V Type I restriction modification DNA specificity domain
HKFIFLAF_01774 2.2e-268 hsdM 2.1.1.72 V Type I restriction-modification system
HKFIFLAF_01776 0.0 hsdR 3.1.21.3 L COG4096 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases
HKFIFLAF_01777 5.6e-275 lysP E amino acid
HKFIFLAF_01778 1.5e-110 K Transcriptional regulator
HKFIFLAF_01779 2.2e-200 ybhR V COG0842 ABC-type multidrug transport system, permease component
HKFIFLAF_01781 1.3e-128 V COG1131 ABC-type multidrug transport system, ATPase component
HKFIFLAF_01782 1.3e-162 fda 4.1.2.13 G Belongs to the class I fructose-bisphosphate aldolase family
HKFIFLAF_01783 2e-26
HKFIFLAF_01784 4.1e-113 E LysE type translocator
HKFIFLAF_01785 6.5e-84 btuE 1.11.1.9 O Belongs to the glutathione peroxidase family
HKFIFLAF_01786 2e-80 2.7.1.199 G COG2190 Phosphotransferase system IIA components
HKFIFLAF_01787 5.1e-150 3.2.1.122, 3.2.1.86 GH4,GT4 G COG1486 Alpha-galactosidases 6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases
HKFIFLAF_01788 2.7e-257 L PFAM Transposase, IS4-like
HKFIFLAF_01789 8.8e-192 mccF 3.4.17.13 V peptidase S66
HKFIFLAF_01790 9.8e-152 ytxC S YtxC-like family
HKFIFLAF_01791 8.4e-176 dnaI L Primosomal protein DnaI
HKFIFLAF_01792 1.9e-261 dnaB L Membrane attachment protein
HKFIFLAF_01793 2.1e-79 nrdR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HKFIFLAF_01794 3.2e-192 gapB 1.2.1.12, 1.2.1.59 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
HKFIFLAF_01795 3.7e-100 coaE 2.7.1.24 F Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HKFIFLAF_01796 1.6e-109 ytaF P Probably functions as a manganese efflux pump
HKFIFLAF_01797 4.2e-155 fpg 3.2.2.23, 4.2.99.18 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
HKFIFLAF_01798 0.0 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HKFIFLAF_01799 1.4e-167 mdh 1.1.1.37 C Catalyzes the reversible oxidation of malate to oxaloacetate
HKFIFLAF_01800 1.5e-244 icd 1.1.1.42 C isocitrate
HKFIFLAF_01801 1.1e-206 citZ 2.3.3.1 C Belongs to the citrate synthase family
HKFIFLAF_01802 2.3e-73 yeaL S Membrane
HKFIFLAF_01803 1.4e-158 ytvI S sporulation integral membrane protein YtvI
HKFIFLAF_01804 0.0 pyk 2.7.1.40, 2.7.7.4 G Belongs to the pyruvate kinase family
HKFIFLAF_01805 3.2e-178 pfkA 2.7.1.11 F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
HKFIFLAF_01806 2.1e-177 accA 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
HKFIFLAF_01807 1.8e-164 accD 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HKFIFLAF_01808 1.3e-224 ytsJ 1.1.1.38 C Malate dehydrogenase
HKFIFLAF_01809 0.0 dnaE 2.7.7.7 L DNA polymerase
HKFIFLAF_01810 1.6e-41 ytrH S Sporulation protein YtrH
HKFIFLAF_01811 7.9e-88 ytrI
HKFIFLAF_01812 2.9e-176 nrnA 3.1.13.3, 3.1.3.7 S COG0618 Exopolyphosphatase-related proteins
HKFIFLAF_01813 5.4e-39 ytpI S YtpI-like protein
HKFIFLAF_01814 1.2e-239 ytoI K transcriptional regulator containing CBS domains
HKFIFLAF_01815 6.3e-252 E amino acid
HKFIFLAF_01816 2.7e-134 lutC S Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source
HKFIFLAF_01817 3e-273 lutB C Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source. Has probably a role as an electron transporter during oxidation of L-lactate
HKFIFLAF_01818 2.5e-135 lutA C Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source
HKFIFLAF_01819 6.9e-251 E Amino acid permease
HKFIFLAF_01820 5.1e-223 yugJ C oxidoreductases, Fe-dependent alcohol dehydrogenase family
HKFIFLAF_01821 3.4e-233 amt P Ammonium transporter
HKFIFLAF_01822 2.5e-297 citS 2.7.13.3 T Signal transduction histidine kinase regulating citrate malate metabolism
HKFIFLAF_01823 4.6e-123 citT T response regulator
HKFIFLAF_01824 6.2e-247 citH C Citrate transporter
HKFIFLAF_01825 4.9e-182 ykoT GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
HKFIFLAF_01826 0.0 helD 3.6.4.12 L DNA helicase
HKFIFLAF_01829 2.2e-19
HKFIFLAF_01831 2.2e-99 glpP K Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HKFIFLAF_01832 1.1e-152 glpF G Belongs to the MIP aquaporin (TC 1.A.8) family
HKFIFLAF_01833 5.8e-288 glpK 2.7.1.30 C Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HKFIFLAF_01834 0.0 glpD 1.1.5.3 C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HKFIFLAF_01835 1.4e-210 dctA U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
HKFIFLAF_01836 7.5e-197 glxK 2.7.1.165 G Belongs to the glycerate kinase type-1 family
HKFIFLAF_01837 7.2e-72 KT Sugar diacid utilization regulator
HKFIFLAF_01838 2.2e-193 bdhA 1.1.1.303, 1.1.1.4 E Dehydrogenase
HKFIFLAF_01839 4.4e-205 U protein localization to endoplasmic reticulum
HKFIFLAF_01840 0.0 nrdD 1.1.98.6 F Ribonucleoside-triphosphate reductase
HKFIFLAF_01841 8.2e-87 nrdG 1.97.1.4 O 4Fe-4S single cluster domain
HKFIFLAF_01842 0.0 L Domain of unknown function (DUF4277)
HKFIFLAF_01844 7.2e-177 V AAA domain (dynein-related subfamily)
HKFIFLAF_01845 7.7e-72
HKFIFLAF_01846 2.3e-152 L Archaeal putative transposase ISC1217
HKFIFLAF_01847 2.7e-19 S Uncharacterized protein conserved in bacteria (DUF2247)
HKFIFLAF_01848 2.8e-39 S Uncharacterized protein conserved in bacteria (DUF2247)
HKFIFLAF_01850 3.7e-219 gltP C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
HKFIFLAF_01851 5.2e-292 hsdM 2.1.1.72 V Type I restriction-modification system
HKFIFLAF_01852 9.7e-108 hsdS 3.1.21.3 V Type I restriction modification DNA specificity domain
HKFIFLAF_01853 0.0 hsdR 3.1.21.3 L Subunit R is required for both nuclease and ATPase activities, but not for modification
HKFIFLAF_01854 6.3e-131 S WLM domain
HKFIFLAF_01855 2.8e-13 yabK S Peptide ABC transporter permease
HKFIFLAF_01856 5.7e-38 yabK S Peptide ABC transporter permease
HKFIFLAF_01857 0.0 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HKFIFLAF_01858 2.1e-91 spoVT K stage V sporulation protein
HKFIFLAF_01859 3.5e-275 yabM S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
HKFIFLAF_01860 8.1e-191 mazG 3.6.1.66, 3.6.1.9 S COG3956 Protein containing tetrapyrrole methyltransferase domain and MazG-like
HKFIFLAF_01861 2.4e-41 yabO J COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
HKFIFLAF_01862 3e-50 yabP S Sporulation protein YabP
HKFIFLAF_01863 8.9e-105 yabQ S spore cortex biosynthesis protein
HKFIFLAF_01864 1.9e-60 divIC D Septum formation initiator
HKFIFLAF_01865 1.1e-53 yabR J RNA binding protein (contains ribosomal protein S1 domain)
HKFIFLAF_01867 0.0 spoIIE 3.1.3.16, 3.1.3.3 KT stage II sporulation protein E
HKFIFLAF_01868 3.3e-119 yabS S protein containing a von Willebrand factor type A (vWA) domain
HKFIFLAF_01869 2.3e-163 KLT serine threonine protein kinase
HKFIFLAF_01870 1.4e-275 tilS 2.4.2.8, 6.3.4.19 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
HKFIFLAF_01871 2.9e-96 hpt 2.4.2.8, 6.3.4.19 F Belongs to the purine pyrimidine phosphoribosyltransferase family
HKFIFLAF_01872 0.0 ftsH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HKFIFLAF_01873 1.7e-159 coaX 2.7.1.33 F Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HKFIFLAF_01874 2.9e-162 hslO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HKFIFLAF_01875 1.3e-168 cysK 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
HKFIFLAF_01876 3.7e-159 folP 2.5.1.15, 2.7.6.3 H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HKFIFLAF_01877 3.2e-62 folB 1.13.11.81, 2.5.1.15, 2.7.6.3, 4.1.2.25, 5.1.99.8 H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HKFIFLAF_01878 1.1e-97 folK 1.13.11.81, 2.5.1.15, 2.7.6.3, 3.5.4.16, 4.1.2.25, 5.1.99.8 H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HKFIFLAF_01881 5.4e-286 lysS 6.1.1.6 J Belongs to the class-II aminoacyl-tRNA synthetase family
HKFIFLAF_01882 2.5e-169 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HKFIFLAF_01883 3.3e-241 yihS 5.1.3.11, 5.3.1.9 G N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)
HKFIFLAF_01884 7.2e-192 yeeE S Sulphur transport
HKFIFLAF_01885 6.9e-36 yeeD O Belongs to the sulfur carrier protein TusA family
HKFIFLAF_01886 1.3e-85 folT 2.7.13.3 T ECF transporter, substrate-specific component
HKFIFLAF_01887 1.8e-113 ywnB S NAD(P)H-binding
HKFIFLAF_01888 3.7e-42 padR K negative regulation of transcription, DNA-templated
HKFIFLAF_01889 3.6e-58 yhcF K Transcriptional regulator
HKFIFLAF_01890 9.2e-127 yhcG V ABC transporter, ATP-binding protein
HKFIFLAF_01891 3.3e-139
HKFIFLAF_01894 0.0 XK27_11280 S Psort location CytoplasmicMembrane, score
HKFIFLAF_01895 2.8e-86 endA 3.1.21.1 L Endonuclease I
HKFIFLAF_01896 3.8e-255 ybhI P Sodium:sulfate symporter transmembrane region
HKFIFLAF_01897 3.4e-13 S PFAM Uncharacterised protein family UPF0236
HKFIFLAF_01898 2.5e-13 S PFAM Uncharacterised protein family UPF0236
HKFIFLAF_01900 2.1e-211 ynfM EGP Major facilitator Superfamily
HKFIFLAF_01901 0.0 ywjA V ABC transporter
HKFIFLAF_01903 2.8e-233 pbuG S permease
HKFIFLAF_01904 2.8e-154 glcT K antiterminator
HKFIFLAF_01905 0.0 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
HKFIFLAF_01906 3.5e-222 gltT C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
HKFIFLAF_01907 5.8e-16 csfB S Inhibitor of sigma-G Gin
HKFIFLAF_01908 2.2e-279 adiA 4.1.1.17, 4.1.1.18, 4.1.1.19 E Orn Lys Arg decarboxylase
HKFIFLAF_01909 2.9e-119 tmk 2.7.4.9 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HKFIFLAF_01910 9.8e-55 yaaQ S protein conserved in bacteria
HKFIFLAF_01911 1.5e-71 yaaR S protein conserved in bacteria
HKFIFLAF_01912 4e-184 holB 2.7.7.7 L DNA polymerase III
HKFIFLAF_01913 1.7e-148 yaaT S stage 0 sporulation protein
HKFIFLAF_01914 3.3e-61 yabA L Involved in initiation control of chromosome replication
HKFIFLAF_01915 2.7e-137 yabB 2.1.1.223 S Conserved hypothetical protein 95
HKFIFLAF_01916 7.1e-49 yazA L endonuclease containing a URI domain
HKFIFLAF_01917 2.2e-162 rsmI 2.1.1.198 H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HKFIFLAF_01918 2.2e-55 abrB K COG2002 Regulators of stationary sporulation gene expression
HKFIFLAF_01919 0.0 metG 6.1.1.10 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HKFIFLAF_01920 8e-148 tatD L hydrolase, TatD
HKFIFLAF_01921 5e-105 rnmV 3.1.26.8 J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HKFIFLAF_01922 1.4e-159 ksgA 2.1.1.182 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
HKFIFLAF_01923 5.8e-163 yabG S peptidase
HKFIFLAF_01924 2.4e-37 veg S protein conserved in bacteria
HKFIFLAF_01925 1.9e-26 sspF S DNA topological change
HKFIFLAF_01926 7.3e-158 ispE 2.1.1.182, 2.7.1.148 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HKFIFLAF_01927 1.3e-152 purR 2.4.2.22, 2.4.2.7 F pur operon repressor
HKFIFLAF_01928 1.2e-61 yabJ 3.5.99.10 J translation initiation inhibitor, yjgF family
HKFIFLAF_01929 6.1e-48 spoVG D Essential for sporulation. Interferes with or is a negative regulator of the pathway leading to asymmetric septation
HKFIFLAF_01930 2.3e-243 glmU 2.3.1.157, 2.7.7.23 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HKFIFLAF_01931 1.2e-174 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HKFIFLAF_01932 2e-112 ctc J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HKFIFLAF_01933 1e-104 pth 3.1.1.29 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
HKFIFLAF_01934 0.0 atl 3.2.1.96, 3.5.1.28 GH73 G Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
HKFIFLAF_01939 1.2e-179 3.1.1.5 I Alpha beta hydrolase
HKFIFLAF_01940 1.5e-109 azoR I Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HKFIFLAF_01941 6.1e-221 adhB 1.1.1.1, 1.1.1.14, 1.1.1.284 E COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
HKFIFLAF_01943 9e-300 2.7.1.12, 2.7.1.17 G xylulose kinase
HKFIFLAF_01944 5.2e-240 yicJ G MFS/sugar transport protein
HKFIFLAF_01945 1.9e-38
HKFIFLAF_01946 7.8e-135 E IrrE N-terminal-like domain
HKFIFLAF_01947 3.2e-59 croE S Helix-turn-helix
HKFIFLAF_01948 0.0 M Peptidase M30
HKFIFLAF_01949 6e-285 xylB 2.7.1.12, 2.7.1.17 G xylulose kinase
HKFIFLAF_01950 9.3e-40 xylA 5.3.1.5 G Belongs to the xylose isomerase family
HKFIFLAF_01951 1.8e-65
HKFIFLAF_01954 1.7e-75 nsrR K Transcriptional regulator
HKFIFLAF_01955 3e-226 hmp 1.14.12.17 C Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HKFIFLAF_01956 1.6e-124 S membrane transporter protein
HKFIFLAF_01957 4e-75 dps P Ferritin-like domain
HKFIFLAF_01958 1.4e-181 mocA S Oxidoreductase
HKFIFLAF_01959 7.3e-208 kinC 2.7.13.3 T COG0642 Signal transduction histidine kinase
HKFIFLAF_01960 5.1e-303 prfC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HKFIFLAF_01961 1.6e-82
HKFIFLAF_01962 1.6e-130 ykoY P COG0861 Membrane protein TerC, possibly involved in tellurium resistance
HKFIFLAF_01963 2.8e-28 sspD S small acid-soluble spore protein
HKFIFLAF_01964 4.3e-19 S Stage 0 Sporulation Regulatory protein
HKFIFLAF_01966 2.2e-287 kinE 2.7.13.3 T Histidine kinase
HKFIFLAF_01967 1.8e-78 ogt 2.1.1.63 L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HKFIFLAF_01968 4.3e-71 XK27_09985 S Protein of unknown function (DUF1232)
HKFIFLAF_01970 0.0 clpE O Belongs to the ClpA ClpB family
HKFIFLAF_01971 6.2e-180 ykvI S membrane
HKFIFLAF_01972 6.2e-103 S Abortive infection protein
HKFIFLAF_01973 4.2e-26 ykvS S protein conserved in bacteria
HKFIFLAF_01974 1.8e-23
HKFIFLAF_01975 3.2e-40 ptsH G phosphocarrier protein HPr
HKFIFLAF_01976 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HKFIFLAF_01977 2.4e-139 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HKFIFLAF_01978 1.5e-158 glxR 1.1.1.31, 1.1.1.60 I COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases
HKFIFLAF_01979 2.3e-215 patA 2.6.1.1 E Aminotransferase
HKFIFLAF_01980 1e-162 cheV 2.7.13.3 T Chemotaxis protein CheV
HKFIFLAF_01981 3.1e-86 ykyB S YkyB-like protein
HKFIFLAF_01982 0.0 ydgH S drug exporters of the RND superfamily
HKFIFLAF_01983 2.1e-17 T Diguanylate cyclase
HKFIFLAF_01984 7.1e-34 T Diguanylate cyclase
HKFIFLAF_01985 2.6e-32
HKFIFLAF_01986 7.9e-140 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HKFIFLAF_01987 1e-162 3.5.1.4 C Acetamidase
HKFIFLAF_01988 5.8e-39 ykuJ S protein conserved in bacteria
HKFIFLAF_01989 6.5e-78 ykuL S CBS domain
HKFIFLAF_01990 4.1e-158 ccpC K Transcriptional regulator
HKFIFLAF_01991 2.1e-70 dapD 2.3.1.117, 2.3.1.89 E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
HKFIFLAF_01992 3.1e-217 hipO 3.5.1.47 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
HKFIFLAF_01993 1.8e-18 S YhfH-like protein
HKFIFLAF_01994 0.0 rnjA S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HKFIFLAF_01995 6.8e-30 ykzG S Belongs to the UPF0356 family
HKFIFLAF_01996 8.6e-204 pdhA 1.2.4.1, 1.2.4.4 C COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
HKFIFLAF_01997 1.3e-179 pdhB 1.2.4.1, 1.2.4.4 C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
HKFIFLAF_01998 3.7e-230 pdhC 2.3.1.12 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
HKFIFLAF_01999 1.7e-260 lpdA 1.8.1.4 C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
HKFIFLAF_02000 4.1e-34
HKFIFLAF_02002 3.2e-275 speA 4.1.1.19 E Arginine
HKFIFLAF_02003 4.5e-48 yktA S Belongs to the UPF0223 family
HKFIFLAF_02004 3.6e-119 yktB S Belongs to the UPF0637 family
HKFIFLAF_02005 1.4e-24
HKFIFLAF_02006 1.3e-150 suhB 3.1.3.25 G Inositol monophosphatase
HKFIFLAF_02007 1.3e-24 S Family of unknown function (DUF5325)
HKFIFLAF_02008 0.0 typA T GTP-binding protein TypA
HKFIFLAF_02009 2.7e-52 ylaH S YlaH-like protein
HKFIFLAF_02010 8e-249 phoH T ATPase related to phosphate starvation-inducible protein PhoH
HKFIFLAF_02011 2.6e-88 ylaL S Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HKFIFLAF_02012 1.5e-43 ylaN S Belongs to the UPF0358 family
HKFIFLAF_02013 1.8e-218 ftsW D Belongs to the SEDS family
HKFIFLAF_02014 5e-176 ctaA 2.5.1.141 O Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group
HKFIFLAF_02015 1.9e-164 ctaB 2.5.1.141 O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
HKFIFLAF_02016 4.9e-196 ctaC 1.9.3.1 C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)
HKFIFLAF_02017 0.0 ctaD 1.10.3.12, 1.9.3.1 C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HKFIFLAF_02018 2.1e-114 cyoC 1.10.3.12, 1.9.3.1 C COG1845 Heme copper-type cytochrome quinol oxidase, subunit 3
HKFIFLAF_02019 1.4e-53 ctaF 1.10.3.12, 1.9.3.1 C COG3125 Heme copper-type cytochrome quinol oxidase, subunit 4
HKFIFLAF_02020 1.7e-168 ctaG S cytochrome c oxidase
HKFIFLAF_02021 9.6e-64 ylbA S YugN-like family
HKFIFLAF_02022 8.6e-167 ylbC S protein with SCP PR1 domains
HKFIFLAF_02023 8.6e-84 yiiD Q protein, possibly involved in aromatic compounds catabolism
HKFIFLAF_02024 2e-70 ylbD S Putative coat protein
HKFIFLAF_02025 2e-36 ylbE S YlbE-like protein
HKFIFLAF_02026 1.6e-64
HKFIFLAF_02027 2.8e-73 ylbF S Belongs to the UPF0342 family
HKFIFLAF_02028 7e-45 ylbG S UPF0298 protein
HKFIFLAF_02029 2.3e-66 S Methylthioribose kinase
HKFIFLAF_02030 6.2e-108 rsmD 2.1.1.171 L Methyltransferase
HKFIFLAF_02031 1.7e-84 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HKFIFLAF_02032 4.2e-220 ylbJ S Sporulation integral membrane protein YlbJ
HKFIFLAF_02033 7.6e-138 ylbK S esterase of the alpha-beta hydrolase superfamily
HKFIFLAF_02034 1.3e-193 ylbL T Belongs to the peptidase S16 family
HKFIFLAF_02035 1.4e-223 ylbM S Belongs to the UPF0348 family
HKFIFLAF_02036 1.2e-93 yceD S metal-binding, possibly nucleic acid-binding protein
HKFIFLAF_02037 1.1e-25 rpmF J Belongs to the bacterial ribosomal protein bL32 family
HKFIFLAF_02038 1.5e-81 rsfA S SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
HKFIFLAF_02039 2.3e-92 ylbP K n-acetyltransferase
HKFIFLAF_02040 1e-159 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HKFIFLAF_02041 0.0 bshC S Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HKFIFLAF_02042 1.4e-77 mraZ K Belongs to the MraZ family
HKFIFLAF_02043 1.7e-173 rsmH 2.1.1.199 J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
HKFIFLAF_02044 1.7e-39 ftsL D Essential cell division protein
HKFIFLAF_02045 0.0 ftsI 3.4.16.4 M Penicillin-binding Protein
HKFIFLAF_02046 0.0 ftsI 3.4.16.4 M stage V sporulation protein D
HKFIFLAF_02047 1.3e-276 murE 6.3.2.10, 6.3.2.13 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HKFIFLAF_02048 1.7e-78 murF 6.3.2.10 M UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HKFIFLAF_02049 8.4e-171 mraY 2.7.8.13 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HKFIFLAF_02050 7.4e-258 murD 6.3.2.9 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HKFIFLAF_02051 1.2e-189 spoVE D Belongs to the SEDS family
HKFIFLAF_02052 9.4e-203 murG 2.4.1.227, 6.3.2.8 GT28 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HKFIFLAF_02053 6.9e-120 divIB D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
HKFIFLAF_02054 1.1e-221 ftsA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
HKFIFLAF_02055 1.2e-189 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HKFIFLAF_02056 8.3e-168 spoIIGA M aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR
HKFIFLAF_02057 3.5e-113 sigE K sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HKFIFLAF_02058 4.4e-138 sigG K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HKFIFLAF_02059 1.9e-43 ylmC S sporulation protein
HKFIFLAF_02060 2.6e-73 yocH CBM50 M 3D domain
HKFIFLAF_02061 2.6e-157 yfiH S Belongs to the multicopper oxidase YfiH RL5 family
HKFIFLAF_02062 3.8e-122 ylmE S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HKFIFLAF_02063 1.1e-64 sepF D Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
HKFIFLAF_02064 2.5e-40 yggT S membrane
HKFIFLAF_02065 3.2e-141 ylmH 5.4.99.23, 5.4.99.24 S conserved protein, contains S4-like domain
HKFIFLAF_02066 3.3e-65 divIVA D Cell division initiation protein
HKFIFLAF_02067 0.0 ileS 6.1.1.5 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HKFIFLAF_02069 1.3e-82 lspA 3.4.23.36 MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HKFIFLAF_02070 4.6e-179 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
HKFIFLAF_02071 2.5e-92 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HKFIFLAF_02072 2e-166 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
HKFIFLAF_02073 8.6e-248 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
HKFIFLAF_02074 1e-212 carA 6.3.5.5 F Carbamoyl-phosphate synthetase glutamine chain
HKFIFLAF_02075 0.0 carB 6.3.5.5 F Belongs to the CarB family
HKFIFLAF_02076 1.2e-140 pyrK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )
HKFIFLAF_02077 4e-181 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
HKFIFLAF_02078 1.1e-122 pyrF 4.1.1.23 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
HKFIFLAF_02079 1.7e-111 pyrE 2.4.2.10, 4.1.1.23 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HKFIFLAF_02080 2.6e-51 S Nuclease-related domain
HKFIFLAF_02081 5.2e-209 L Transposase IS4 family protein
HKFIFLAF_02082 2.2e-14 rhaD 4.1.2.17, 4.1.2.19, 5.1.3.4 G Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde
HKFIFLAF_02083 3.8e-75 mgsA 2.7.1.24, 4.2.3.3 G methylglyoxal synthase
HKFIFLAF_02085 1.1e-23 S double-stranded DNA endodeoxyribonuclease activity
HKFIFLAF_02086 1.1e-103 ygfA 6.3.3.2 H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HKFIFLAF_02087 2.5e-242 EGP Major facilitator Superfamily
HKFIFLAF_02088 1.7e-247 lmrB EGP the major facilitator superfamily
HKFIFLAF_02089 5.1e-96 yxaF_1 K Transcriptional regulator
HKFIFLAF_02090 8.4e-14 atsK 1.14.11.17 Q PFAM Taurine catabolism dioxygenase TauD TfdA
HKFIFLAF_02091 1.5e-24 yvaE U Small Multidrug Resistance protein
HKFIFLAF_02092 2.7e-45 3.6.3.36 P ATPases associated with a variety of cellular activities
HKFIFLAF_02093 8.7e-30 3.6.3.36 P ABC transporter
HKFIFLAF_02094 9.3e-193 S AI-2E family transporter
HKFIFLAF_02095 3e-143 S hydrolases of the HAD superfamily
HKFIFLAF_02096 1.1e-85 S FAD binding domain
HKFIFLAF_02097 5.5e-222 S FAD binding domain
HKFIFLAF_02098 2.5e-228 L PFAM Transposase, IS116 IS110 IS902
HKFIFLAF_02099 4.6e-263 yihP G MFS/sugar transport protein
HKFIFLAF_02101 1.8e-79 L DDE superfamily endonuclease
HKFIFLAF_02109 1.7e-07
HKFIFLAF_02110 8.7e-08
HKFIFLAF_02114 1.6e-08
HKFIFLAF_02117 8.3e-76 yetF3 K membrane
HKFIFLAF_02118 3.8e-190 C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKFIFLAF_02119 2.1e-263 S PFAM Uncharacterised protein family UPF0236
HKFIFLAF_02121 7e-15 M Host cell surface-exposed lipoprotein
HKFIFLAF_02122 4.2e-206 adhC 1.1.1.1 C Zinc-binding dehydrogenase
HKFIFLAF_02124 7.7e-155 yxxF EG EamA-like transporter family
HKFIFLAF_02125 4.2e-245 ydjE EGP Major facilitator superfamily
HKFIFLAF_02126 2.1e-126 tetV EGP Transmembrane secretion effector
HKFIFLAF_02127 1.6e-127
HKFIFLAF_02128 7.4e-67 V ATPases associated with a variety of cellular activities
HKFIFLAF_02129 1.5e-59 S Predicted membrane protein (DUF2243)
HKFIFLAF_02130 4.1e-78 S Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)
HKFIFLAF_02131 4.6e-58 K MarR family
HKFIFLAF_02132 2e-42 yqfU S Uncharacterized protein conserved in bacteria (DUF2179)
HKFIFLAF_02133 1.7e-54 gntK 2.7.1.12, 2.7.1.17 G FGGY family of carbohydrate kinases, N-terminal domain
HKFIFLAF_02134 1.6e-185 ytlA P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components
HKFIFLAF_02135 3.9e-139 ytlC P ABC transporter
HKFIFLAF_02136 3.1e-126 ytlD P COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component
HKFIFLAF_02137 2e-85 ytkD 3.6.1.55 L COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
HKFIFLAF_02138 7.4e-39
HKFIFLAF_02139 9.5e-77 dps P Belongs to the Dps family
HKFIFLAF_02140 6.4e-40 yidD S Could be involved in insertion of integral membrane proteins into the membrane
HKFIFLAF_02142 1.6e-160 adcA P Belongs to the bacterial solute-binding protein 9 family
HKFIFLAF_02143 2.1e-23 S Domain of Unknown Function (DUF1540)
HKFIFLAF_02144 2.2e-204 menC 4.2.1.113 H Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)
HKFIFLAF_02145 6.9e-270 menE 6.2.1.26 H Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily
HKFIFLAF_02146 1.9e-155 menB 4.1.3.36 H Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HKFIFLAF_02147 2.2e-153 menH 4.2.99.20 S Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC)
HKFIFLAF_02148 0.0 menD 2.2.1.9 H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HKFIFLAF_02149 1e-251 menF 5.4.4.2 HQ Isochorismate synthase
HKFIFLAF_02150 9.4e-164 menA 2.5.1.74 H Belongs to the MenA family. Type 1 subfamily
HKFIFLAF_02160 3e-09
HKFIFLAF_02166 5.1e-08
HKFIFLAF_02167 1.6e-08
HKFIFLAF_02175 1.7e-07
HKFIFLAF_02176 1.5e-07
HKFIFLAF_02180 1.1e-169 rocF 3.5.3.1, 3.5.3.11 E Belongs to the arginase family
HKFIFLAF_02182 7.2e-98 sigW K Belongs to the sigma-70 factor family. ECF subfamily
HKFIFLAF_02183 6.4e-116 rsiW K Is the anti-sigma factor for SigW. The presence of RsiW leads to the inactivation of SigW, and its proteolytic destruction to sigma-W activation
HKFIFLAF_02185 5.5e-147 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HKFIFLAF_02186 1.8e-221 ybbR S protein conserved in bacteria
HKFIFLAF_02187 5.5e-253 glmM 5.4.2.10 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HKFIFLAF_02188 0.0 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
HKFIFLAF_02191 3.6e-96 M1-431 S Protein of unknown function (DUF1706)
HKFIFLAF_02192 6.8e-144 3.1.2.21 I Acyl-ACP thioesterase
HKFIFLAF_02194 2.2e-216 G Major facilitator Superfamily
HKFIFLAF_02195 2.9e-199 EGP Major facilitator Superfamily
HKFIFLAF_02196 1e-151 K Bacterial regulatory helix-turn-helix protein, lysR family
HKFIFLAF_02197 9.2e-138 cobB K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form
HKFIFLAF_02198 6.4e-75 ganB 3.2.1.89 G arabinogalactan
HKFIFLAF_02199 2.8e-26 S Protein of unknown function (DUF3006)
HKFIFLAF_02200 2.1e-241 L Metallo-beta-lactamase superfamily
HKFIFLAF_02201 2e-49 S Protein of unknown function (DUF1648)
HKFIFLAF_02202 6.6e-65 yjbR S YjbR
HKFIFLAF_02203 7.9e-177 1.13.12.16, 1.3.1.9 S COG2070 Dioxygenases related to 2-nitropropane dioxygenase
HKFIFLAF_02204 9.6e-65 araD 4.1.2.17, 5.1.3.4 G Class II Aldolase and Adducin N-terminal domain
HKFIFLAF_02205 6.3e-142 S HIRAN domain
HKFIFLAF_02206 2.1e-162 S HipA-like C-terminal domain
HKFIFLAF_02207 0.0 gtfC 2.4.1.5 GH13 M KxYKxGKxW signal domain protein
HKFIFLAF_02208 3.8e-58 S PD-(D/E)XK nuclease family transposase
HKFIFLAF_02209 8.7e-57 S PD-(D/E)XK nuclease family transposase
HKFIFLAF_02210 3.6e-60 3.2.1.96 M cysteine-type peptidase activity
HKFIFLAF_02213 1.5e-85 dprA LU Rossmann fold nucleotide-binding protein involved in DNA uptake
HKFIFLAF_02214 2.4e-83 S Haloacid dehalogenase-like hydrolase
HKFIFLAF_02215 6e-257 L PFAM Transposase, IS4-like
HKFIFLAF_02216 1.7e-102
HKFIFLAF_02217 3.7e-298 hsdM 2.1.1.72 V Type I restriction-modification system
HKFIFLAF_02218 7.6e-148 hsdS 3.1.21.3 V Type I restriction modification DNA specificity domain
HKFIFLAF_02219 0.0 hsdR 3.1.21.3 L Subunit R is required for both nuclease and ATPase activities, but not for modification
HKFIFLAF_02220 1.5e-172 mcrB L Restriction endonuclease
HKFIFLAF_02221 2.5e-172 ydhF S Oxidoreductase
HKFIFLAF_02222 1.2e-48
HKFIFLAF_02223 4.7e-174 K cell envelope-related transcriptional attenuator
HKFIFLAF_02224 0.0 3.2.1.78 GH26 O cellulase activity
HKFIFLAF_02225 0.0 ybeC E amino acid
HKFIFLAF_02226 4.7e-19 csd2 L CRISPR-associated protein Cas7
HKFIFLAF_02227 1.6e-291 csd1 S CRISPR-associated protein (Cas_Csd1)
HKFIFLAF_02228 4.7e-163 L Transposase
HKFIFLAF_02229 2e-98 L Bacterial dnaA protein
HKFIFLAF_02230 7.6e-192 yjdA S LXG domain of WXG superfamily
HKFIFLAF_02231 6e-138
HKFIFLAF_02232 6.5e-76
HKFIFLAF_02233 2.6e-74
HKFIFLAF_02234 1e-81 S Domain of unknown function (DUF5085)
HKFIFLAF_02235 3.5e-140 tesE Q COG3971 2-keto-4-pentenoate hydratase
HKFIFLAF_02236 2.4e-259 proP EGP Transporter
HKFIFLAF_02237 1.6e-157 pdxS 4.3.3.6 H Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HKFIFLAF_02238 1.3e-102 pdxT 4.3.3.6 H Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HKFIFLAF_02239 1.1e-210 serS 6.1.1.11 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HKFIFLAF_02240 2.9e-09
HKFIFLAF_02241 3.3e-126 dck 2.7.1.113, 2.7.1.74, 2.7.1.76 F Deoxycytidine kinase
HKFIFLAF_02242 1.4e-118 dgk 2.7.1.113, 2.7.1.74, 2.7.1.76 F Deoxyguanosine kinase
HKFIFLAF_02243 2.9e-251 yaaH M Glycoside Hydrolase Family
HKFIFLAF_02244 2.1e-88 tadA 3.5.4.1, 3.5.4.33 FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
HKFIFLAF_02245 1.4e-306 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HKFIFLAF_02246 1.3e-35 yaaK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HKFIFLAF_02247 1.5e-109 recR L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HKFIFLAF_02248 3.4e-08 yaaL S Protein of unknown function (DUF2508)
HKFIFLAF_02249 7.5e-37 bofA S Sigma-K factor-processing regulatory protein BofA
HKFIFLAF_02250 2.4e-39 S PFAM Uncharacterised protein family UPF0236
HKFIFLAF_02251 1.8e-112 cah5 3.1.1.41 Q Acetyl xylan esterase (AXE1)
HKFIFLAF_02252 1.6e-302 rafA 3.2.1.22 G Alpha-galactosidase
HKFIFLAF_02253 1.7e-241 bgl2 3.2.1.21, 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
HKFIFLAF_02254 5.3e-108 bglK_1 2.7.1.2 GK ROK family
HKFIFLAF_02255 6.3e-104 rnbP 5.1.3.11 G Catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man)
HKFIFLAF_02256 5.2e-131 VP1224 V Polysaccharide biosynthesis C-terminal domain
HKFIFLAF_02257 1.7e-128 G 1,4-beta-xylanase
HKFIFLAF_02258 1.6e-19 S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HKFIFLAF_02259 2.5e-68 lrpC K Transcriptional regulator
HKFIFLAF_02261 1.2e-55 S protein conserved in bacteria
HKFIFLAF_02262 2.4e-30 P Copper resistance protein CopZ
HKFIFLAF_02263 0.0 copA 3.6.3.54 P P-type ATPase
HKFIFLAF_02264 1.7e-55 EGP Major facilitator Superfamily
HKFIFLAF_02265 3.1e-166 S Protein of unknown function (DUF1646)
HKFIFLAF_02266 2.1e-115 sapB S MgtC SapB transporter
HKFIFLAF_02267 1.7e-149 EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
HKFIFLAF_02268 1e-21
HKFIFLAF_02269 3.4e-194 yegQ O COG0826 Collagenase and related proteases
HKFIFLAF_02270 1.9e-169 yegQ O Peptidase U32
HKFIFLAF_02271 3.3e-37 spoVS S Stage V sporulation protein S
HKFIFLAF_02272 1.9e-152 ymdB S protein conserved in bacteria
HKFIFLAF_02273 5.6e-217 rny S Endoribonuclease that initiates mRNA decay
HKFIFLAF_02274 6.4e-188 recA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HKFIFLAF_02275 1e-226 cinA 3.5.1.42 S Belongs to the CinA family
HKFIFLAF_02276 1.3e-99 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HKFIFLAF_02277 1.5e-137 ymfM S protein conserved in bacteria
HKFIFLAF_02278 1e-142 ymfK S Protein of unknown function (DUF3388)
HKFIFLAF_02279 6.4e-41 ymfJ S Protein of unknown function (DUF3243)
HKFIFLAF_02280 4.5e-138 1.1.1.100 S Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
HKFIFLAF_02281 1.8e-245 ymfH S zinc protease
HKFIFLAF_02282 2.1e-238 ymfF S Peptidase M16
HKFIFLAF_02283 0.0 ftsK D Belongs to the FtsK SpoIIIE SftA family
HKFIFLAF_02284 4.3e-35 S YlzJ-like protein
HKFIFLAF_02285 5.8e-132 tepA 3.4.21.92 OU COG0740 Protease subunit of ATP-dependent Clp proteases
HKFIFLAF_02287 0.0 rnjB S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HKFIFLAF_02288 3.9e-159 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HKFIFLAF_02289 1.1e-228 dapG 1.1.1.3, 2.7.2.4 E Belongs to the aspartokinase family
HKFIFLAF_02290 9.9e-194 asd 1.2.1.11 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HKFIFLAF_02291 2.6e-109 spoVFB H Together with DpaA, catalyzes the conversion of dihydrodipicolinate to dipicolinate (DPA)
HKFIFLAF_02292 1.6e-185 dpaA 1.1.1.29, 1.1.1.399, 1.1.1.95 CH Dipicolinate synthase subunit A
HKFIFLAF_02293 1.4e-37 ymxH S YlmC YmxH family
HKFIFLAF_02294 1.1e-231 pepR S Belongs to the peptidase M16 family
HKFIFLAF_02295 1.2e-208 ylxY 3.5.1.104 G Sporulation protein, polysaccharide deacetylase
HKFIFLAF_02296 0.0 pnp 2.7.7.8 J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
HKFIFLAF_02297 1e-41 rpsO J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HKFIFLAF_02298 3.6e-182 ribF 2.7.1.26, 2.7.7.2 H Belongs to the ribF family
HKFIFLAF_02299 3.5e-171 truB 5.4.99.25 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HKFIFLAF_02300 3.2e-56 rbfA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HKFIFLAF_02301 8.6e-44 ylxP S protein conserved in bacteria
HKFIFLAF_02302 0.0 infB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HKFIFLAF_02303 2.9e-48 ylxQ J ribosomal protein
HKFIFLAF_02304 8.2e-45 ylxR K nucleic-acid-binding protein implicated in transcription termination
HKFIFLAF_02305 1.8e-223 nusA K Participates in both transcription termination and antitermination
HKFIFLAF_02306 7.1e-83 rimP S Required for maturation of 30S ribosomal subunits
HKFIFLAF_02307 0.0 polC 2.7.7.7 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HKFIFLAF_02308 0.0 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
HKFIFLAF_02309 3.3e-236 rasP M zinc metalloprotease
HKFIFLAF_02310 4.9e-194 dxr 1.1.1.267 I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
HKFIFLAF_02311 4.7e-143 cdsA 2.7.7.41 S Belongs to the CDS family
HKFIFLAF_02312 5e-145 uppS 2.5.1.31 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HKFIFLAF_02313 6.9e-93 frr J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
HKFIFLAF_02314 1.1e-127 pyrH 2.7.4.22 F Catalyzes the reversible phosphorylation of UMP to UDP
HKFIFLAF_02315 6.3e-157 tsf J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HKFIFLAF_02316 1.1e-136 rpsB J Belongs to the universal ribosomal protein uS2 family
HKFIFLAF_02317 4e-77 ylxL
HKFIFLAF_02318 1.6e-135 sigD K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HKFIFLAF_02319 8.9e-84 cheD 3.5.1.44 NT Deamidates glutamine residues to glutamate on methyl- accepting chemotaxis receptors (MCPs). CheD-mediated MCP deamidation is required for productive communication of the conformational signals of the chemoreceptors to the CheA kinase
HKFIFLAF_02320 1.1e-113 cheC NT COG1776 Chemotaxis protein CheC, inhibitor of MCP methylation
HKFIFLAF_02321 8.2e-70 cheW NT COG0835 Chemotaxis signal transduction protein
HKFIFLAF_02322 0.0 cheA 2.7.13.3 NT COG0643 Chemotaxis protein histidine kinase and related kinases
HKFIFLAF_02323 5.8e-115 cheB 3.1.1.61, 3.5.1.44 NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR
HKFIFLAF_02324 1.2e-144 flhG D Belongs to the ParA family
HKFIFLAF_02325 1.4e-196 flhF N Flagellar biosynthesis regulator FlhF
HKFIFLAF_02326 0.0 flhA N Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HKFIFLAF_02327 8.4e-188 flhB N Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HKFIFLAF_02328 4.3e-133 fliR N Flagellar biosynthetic protein FliR
HKFIFLAF_02329 1.5e-37 fliQ N Role in flagellar biosynthesis
HKFIFLAF_02330 2.6e-107 fliP N Plays a role in the flagellum-specific transport system
HKFIFLAF_02331 2.1e-115 fliZ N Flagellar biosynthesis protein, FliO
HKFIFLAF_02332 2.1e-58 cheB 3.1.1.61, 3.5.1.44 T response regulator
HKFIFLAF_02333 1.7e-175 fliN N FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HKFIFLAF_02334 6.4e-182 fliM N One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation
HKFIFLAF_02335 1.3e-64 fliL N Controls the rotational direction of flagella during chemotaxis
HKFIFLAF_02336 3e-131 flgG N Flagellar basal body rod
HKFIFLAF_02337 3.1e-75 flg N Putative flagellar
HKFIFLAF_02338 2.3e-108 flgD N Flagellar basal body rod modification protein
HKFIFLAF_02339 5.5e-281 fliK N Flagellar hook-length control
HKFIFLAF_02340 3.4e-40 ylxF S MgtE intracellular N domain
HKFIFLAF_02341 1.6e-68 fliJ N Flagellar biosynthesis chaperone
HKFIFLAF_02342 3.4e-247 fliI 3.6.3.14 NU COG1157 Flagellar biosynthesis type III secretory pathway ATPase
HKFIFLAF_02343 7.5e-127 fliH NU COG1317 Flagellar biosynthesis type III secretory pathway protein
HKFIFLAF_02344 2.7e-164 fliG N One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation
HKFIFLAF_02345 2.6e-246 fliF N The M ring may be actively involved in energy transduction
HKFIFLAF_02346 9.9e-41 fliE N Flagellar hook-basal body complex protein FliE
HKFIFLAF_02347 4e-75 flgC N Belongs to the flagella basal body rod proteins family
HKFIFLAF_02348 3.7e-61 flgB N Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body
HKFIFLAF_02349 8.6e-134 codY K DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HKFIFLAF_02350 2.5e-224 hslU O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HKFIFLAF_02351 7.4e-92 hslV 3.4.25.2 O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HKFIFLAF_02352 1.5e-169 xerC L tyrosine recombinase XerC
HKFIFLAF_02354 0.0 topA 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HKFIFLAF_02355 4.5e-163 dprA LU Rossmann fold nucleotide-binding protein involved in DNA uptake
HKFIFLAF_02356 5.8e-166 sucD 6.2.1.5 C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HKFIFLAF_02357 2.1e-213 sucC 6.2.1.5 C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
HKFIFLAF_02358 3.6e-45 ylqH S homolog of the cytoplasmic domain of flagellar protein FhlB
HKFIFLAF_02359 2.9e-232 CP_1081 D nuclear chromosome segregation
HKFIFLAF_02360 2.5e-133 rnhB 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HKFIFLAF_02361 3.5e-157 ylqF S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HKFIFLAF_02362 3.6e-102 lepB 3.4.21.89 U Belongs to the peptidase S26 family
HKFIFLAF_02363 1.9e-56 rplS J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
HKFIFLAF_02364 8.9e-141 trmD 2.1.1.228, 4.6.1.12 J Belongs to the RNA methyltransferase TrmD family
HKFIFLAF_02365 5.8e-94 rimM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HKFIFLAF_02366 3.2e-60 ylqD S YlqD protein
HKFIFLAF_02367 4.7e-35 ylqC S Belongs to the UPF0109 family
HKFIFLAF_02368 2.2e-44 rpsP J Belongs to the bacterial ribosomal protein bS16 family
HKFIFLAF_02369 5.1e-243 ffh 3.6.5.4 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HKFIFLAF_02370 2.6e-52 ylxM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HKFIFLAF_02371 1.7e-179 ftsY U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HKFIFLAF_02372 0.0 smc D Required for chromosome condensation and partitioning
HKFIFLAF_02373 4.5e-132 rnc 3.1.26.3 J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
HKFIFLAF_02374 3.7e-32 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
HKFIFLAF_02375 1.8e-128 IQ reductase
HKFIFLAF_02376 1.3e-163 fabD 2.3.1.39 I malonyl CoA-acyl carrier protein transacylase
HKFIFLAF_02377 1e-176 plsX 2.3.1.15 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
HKFIFLAF_02378 8.8e-99 fapR 5.3.1.23 Q Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism
HKFIFLAF_02379 0.0 recG 3.6.4.12 L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HKFIFLAF_02380 2.6e-155 sdaAA 4.3.1.17 E L-serine dehydratase
HKFIFLAF_02381 1.6e-120 sdaAB 4.3.1.17 E L-serine dehydratase
HKFIFLAF_02382 2.3e-311 yloV S kinase related to dihydroxyacetone kinase
HKFIFLAF_02383 6.5e-60 asp S protein conserved in bacteria
HKFIFLAF_02384 5e-27 rpmB J Belongs to the bacterial ribosomal protein bL28 family
HKFIFLAF_02385 2.6e-123 thiN 2.7.6.2 H thiamine pyrophosphokinase
HKFIFLAF_02386 5.9e-120 rpe 5.1.3.1 G Belongs to the ribulose-phosphate 3-epimerase family
HKFIFLAF_02387 5.1e-167 rsgA 3.1.3.100 S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
HKFIFLAF_02388 0.0 prkC 2.7.11.1 KLT serine threonine protein kinase
HKFIFLAF_02389 6.1e-137 stp 3.1.3.16 T phosphatase
HKFIFLAF_02390 3.2e-253 sun 2.1.1.176 J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HKFIFLAF_02391 3.5e-177 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HKFIFLAF_02392 5.1e-84 def 2.1.2.9, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
HKFIFLAF_02393 0.0 priA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HKFIFLAF_02394 3.8e-221 coaBC 4.1.1.36, 6.3.2.5 H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HKFIFLAF_02395 3.4e-29 rpoZ 2.7.7.6 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
HKFIFLAF_02396 3.7e-108 gmk 2.7.4.8 F Essential for recycling GMP and indirectly, cGMP
HKFIFLAF_02397 3.5e-46 ylzA S Belongs to the UPF0296 family
HKFIFLAF_02398 7.1e-153 yicC S stress-induced protein
HKFIFLAF_02399 0.0 yloB 3.6.3.8 P COG0474 Cation transport ATPase
HKFIFLAF_02400 0.0 FbpA K RNA-binding protein homologous to eukaryotic snRNP
HKFIFLAF_02401 5.3e-165 yocS S -transporter
HKFIFLAF_02402 9.1e-138 queE 1.97.1.4, 4.3.99.3 H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
HKFIFLAF_02403 1.8e-89 queD 4.1.2.50, 4.2.3.12 H 6-pyruvoyl tetrahydropterin synthase
HKFIFLAF_02405 1.3e-11 5.1.1.13 M Belongs to the aspartate glutamate racemases family
HKFIFLAF_02406 1.7e-51
HKFIFLAF_02407 1e-99 purD 6.3.4.13 F phosphoribosylamine-glycine ligase activity
HKFIFLAF_02408 5e-58 3.1.4.46, 5.4.2.11 C glycerophosphoryl diester phosphodiesterase
HKFIFLAF_02409 1.6e-25 6.2.1.3 IQ AMP-binding enzyme C-terminal domain
HKFIFLAF_02410 3.8e-195 S Metallo-beta-lactamase superfamily
HKFIFLAF_02411 1.8e-136 phnC 3.6.3.28 P Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HKFIFLAF_02412 3e-134 phnE 3.6.1.63 P ABC transporter
HKFIFLAF_02413 1.8e-142 phnE 3.6.1.63 P ABC transporter
HKFIFLAF_02414 7.2e-175 phnD P Phosphonate ABC transporter
HKFIFLAF_02415 0.0 cpdB 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
HKFIFLAF_02416 2.1e-207 ysdC G COG1363 Cellulase M and related proteins
HKFIFLAF_02420 4.2e-138 spoIISA S Toxin SpoIISA, type II toxin-antitoxin system
HKFIFLAF_02421 5e-87 yvbK 3.1.3.25 K acetyltransferase
HKFIFLAF_02422 1.7e-95 VPA1573 J acetyltransferase
HKFIFLAF_02423 6.5e-75 MA20_02285 2.3.1.57 K Acetyltransferase (GNAT) family
HKFIFLAF_02424 1.1e-136 IQ Enoyl-(Acyl carrier protein) reductase
HKFIFLAF_02425 9.3e-123 thiM 2.7.1.50 H Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HKFIFLAF_02426 7.8e-146 thiD 2.5.1.3, 2.7.1.35, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Phosphomethylpyrimidine kinase
HKFIFLAF_02427 1.4e-113 thiE 2.5.1.3, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
HKFIFLAF_02428 2.5e-08 ykyB S YkyB-like protein
HKFIFLAF_02429 2.5e-126 yflK S protein conserved in bacteria
HKFIFLAF_02430 1.2e-49
HKFIFLAF_02431 4.9e-13 S Double zinc ribbon
HKFIFLAF_02432 2.3e-92 tcaA S response to antibiotic
HKFIFLAF_02433 8.9e-120 nagZ 3.2.1.52 G Belongs to the glycosyl hydrolase 3 family
HKFIFLAF_02434 2.6e-158 L RNA-directed DNA polymerase (reverse transcriptase)
HKFIFLAF_02435 2e-178 C 4Fe-4S single cluster domain
HKFIFLAF_02436 2.8e-07 sodA 1.15.1.1 P Iron/manganese superoxide dismutases, alpha-hairpin domain
HKFIFLAF_02437 1.2e-109 lexA 3.4.21.88 K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HKFIFLAF_02438 1e-51 yneA D Inhibits cell division during the SOS response. Affects a later stage of the cell division protein assembly, after the assembly of the Z ring, by probably suppressing recruitment of FtsL and or DivIC to the division machinery
HKFIFLAF_02439 1.5e-115 yneB L resolvase
HKFIFLAF_02440 3.4e-33 ynzC S UPF0291 protein
HKFIFLAF_02441 0.0 tkt 2.2.1.1 G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HKFIFLAF_02442 4.2e-77 yneE S Sporulation inhibitor of replication protein sirA
HKFIFLAF_02443 6.8e-28 yneF S UPF0154 protein
HKFIFLAF_02444 1.9e-127 ccdA O cytochrome c biogenesis protein
HKFIFLAF_02445 1.6e-58 cheB 3.1.1.61, 3.5.1.44 T cheY-homologous receiver domain
HKFIFLAF_02446 9.8e-255 NT Chemoreceptor zinc-binding domain
HKFIFLAF_02447 1.2e-125 S Putative adhesin
HKFIFLAF_02448 2.3e-96 S Protein of unknown function (DUF1700)
HKFIFLAF_02449 1.4e-53 K PadR family transcriptional regulator
HKFIFLAF_02450 1e-187 NT chemotaxis protein
HKFIFLAF_02451 1.1e-77 S Transposase zinc-binding domain
HKFIFLAF_02452 3.4e-11 L Transposase IS200 like
HKFIFLAF_02453 3.3e-46 L COG2963 Transposase and inactivated derivatives
HKFIFLAF_02454 3.5e-154 L COG2801 Transposase and inactivated derivatives
HKFIFLAF_02456 5.7e-92 ydhQ K UTRA
HKFIFLAF_02461 1.6e-08
HKFIFLAF_02469 2.7e-93 ydcK S Belongs to the SprT family
HKFIFLAF_02470 0.0 yhgF K COG2183 Transcriptional accessory protein
HKFIFLAF_02471 6e-164 G Bacterial extracellular solute-binding protein
HKFIFLAF_02472 1.7e-82 G Binding-protein-dependent transport system inner membrane component
HKFIFLAF_02473 1.2e-104 malG G Binding-protein-dependent transport system inner membrane component
HKFIFLAF_02474 4.9e-85 K Transcriptional regulator
HKFIFLAF_02475 3.6e-179 yaaC S YaaC-like Protein
HKFIFLAF_02476 1.5e-272 guaB 1.1.1.205 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
HKFIFLAF_02477 8.5e-251 dacA 3.4.16.4 M Belongs to the peptidase S11 family
HKFIFLAF_02478 1.1e-73 K DNA-templated transcription, initiation
HKFIFLAF_02480 1.9e-250 L PFAM transposase IS4 family protein
HKFIFLAF_02484 6e-163 yfhF S nucleoside-diphosphate sugar epimerase
HKFIFLAF_02485 1.8e-209 M Glycosyl hydrolases family 25
HKFIFLAF_02486 8.9e-130 ubiE Q Methyltransferase type 11
HKFIFLAF_02487 0.0 S Protein of unknown function (DUF1524)
HKFIFLAF_02488 3.5e-249 S Protein of unknown function DUF262
HKFIFLAF_02489 3e-76 L Transposase, IS4 family protein
HKFIFLAF_02490 2.1e-268 rumA 2.1.1.190 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HKFIFLAF_02491 1.9e-50 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
HKFIFLAF_02492 0.0 rafA 3.2.1.22 G Alpha-galactosidase
HKFIFLAF_02493 5.8e-109 proA_2 H Methyltransferase
HKFIFLAF_02494 1.4e-225 yhdR 2.6.1.1 E Aminotransferase
HKFIFLAF_02495 6.3e-111 yhbD K Protein of unknown function (DUF4004)
HKFIFLAF_02497 4.6e-247 yeeO V Mate efflux family protein
HKFIFLAF_02498 3e-159 mmgB 1.1.1.157 I Dehydrogenase
HKFIFLAF_02499 0.0 L AAA domain
HKFIFLAF_02500 1.8e-242 yhaO L Calcineurin-like phosphoesterase superfamily domain
HKFIFLAF_02501 4.3e-32 K sequence-specific DNA binding
HKFIFLAF_02502 8.9e-96 1.5.1.38 S FMN reductase
HKFIFLAF_02503 7.4e-19 S Aldo/keto reductase family
HKFIFLAF_02504 7.7e-140 I alpha/beta hydrolase fold
HKFIFLAF_02505 2e-21 M Spore coat protein
HKFIFLAF_02506 1.1e-146 yvaK 3.1.1.1 S BAAT / Acyl-CoA thioester hydrolase C terminal
HKFIFLAF_02508 9.2e-144 ykrA S hydrolases of the HAD superfamily
HKFIFLAF_02509 1.7e-91 hxlB 4.1.2.43, 5.3.1.27 M arabinose-5-phosphate isomerase activity
HKFIFLAF_02510 4.1e-175 ykvZ 5.1.1.1 K Transcriptional regulator
HKFIFLAF_02511 1e-70 gutA G MFS/sugar transport protein
HKFIFLAF_02512 2.6e-227 yfkA S YfkB-like domain
HKFIFLAF_02513 9.1e-79
HKFIFLAF_02514 3.1e-27
HKFIFLAF_02515 9.6e-71 yxiE T Belongs to the universal stress protein A family
HKFIFLAF_02516 2e-223 ykvU S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
HKFIFLAF_02517 5.9e-149 aacC 2.3.1.81 V aminoglycoside
HKFIFLAF_02518 5.3e-181 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HKFIFLAF_02519 8e-100 bioY S Biotin biosynthesis protein
HKFIFLAF_02520 5e-139 map 3.4.11.18 E Methionine aminopeptidase
HKFIFLAF_02521 4.7e-76 lytE CBM50 M COG0791 Cell wall-associated hydrolases (invasion-associated proteins)
HKFIFLAF_02522 1.5e-78
HKFIFLAF_02523 9.4e-198 yfmL 3.6.4.13 L COG0513 Superfamily II DNA and RNA helicases
HKFIFLAF_02524 0.0 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
HKFIFLAF_02525 1.3e-171 corA P Mg2 transporter protein CorA family protein
HKFIFLAF_02528 6.1e-234 panF H Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HKFIFLAF_02529 9.6e-48 yhdT S Sodium pantothenate symporter
HKFIFLAF_02530 1.8e-164 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
HKFIFLAF_02531 1.9e-283 nnrD 4.2.1.136, 5.1.99.6 G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HKFIFLAF_02532 1.1e-18 S Protein of unknown function (DUF4064)
HKFIFLAF_02533 3.5e-143 3.5.3.1, 3.5.3.11 E Belongs to the arginase family
HKFIFLAF_02534 9.3e-242 hom 1.1.1.3 E homoserine dehydrogenase
HKFIFLAF_02535 6.3e-196 thrC 4.2.3.1 E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HKFIFLAF_02536 9.1e-159 thrB 2.7.1.39 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
HKFIFLAF_02537 8e-137 P ABC transporter, ATP-binding protein
HKFIFLAF_02538 7.5e-183 M1-596 P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components
HKFIFLAF_02539 1.1e-139 ssuC_1 P binding-protein-dependent transport systems inner membrane component
HKFIFLAF_02540 1.4e-50 M1-594 S Thiamine-binding protein
HKFIFLAF_02542 3.4e-272 nylA 3.5.1.4 J Belongs to the amidase family
HKFIFLAF_02543 9.7e-80 S Heat induced stress protein YflT
HKFIFLAF_02544 2.9e-160 prpB 4.1.3.30 G Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HKFIFLAF_02545 4.8e-279 prpD 4.2.1.79 S 2-methylcitrate dehydratase
HKFIFLAF_02546 6.2e-210 prpC 2.3.3.1, 2.3.3.5 C Belongs to the citrate synthase family
HKFIFLAF_02547 9.1e-65 manO S Domain of unknown function (DUF956)
HKFIFLAF_02548 3.1e-167 manN G COG3716 Phosphotransferase system, mannose fructose N-acetylgalactosamine-specific component IID
HKFIFLAF_02549 2e-117 manY G COG3715 Phosphotransferase system, mannose fructose N-acetylgalactosamine-specific component IIC
HKFIFLAF_02550 2.7e-177 manL 2.7.1.191 G PTS system mannose fructose sorbose family
HKFIFLAF_02551 1.2e-83 manX 2.7.1.191 G PTS system sorbose subfamily IIB component
HKFIFLAF_02552 0.0 levR K PTS system fructose IIA component
HKFIFLAF_02554 0.0 S ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HKFIFLAF_02555 1.6e-199 pgl 3.1.1.31 G 6-phosphogluconolactonase
HKFIFLAF_02556 4.9e-48 yqgV S Thiamine-binding protein
HKFIFLAF_02557 0.0 pip S YhgE Pip N-terminal domain protein
HKFIFLAF_02558 1.8e-33 relA_2 2.7.6.5, 3.1.7.2 KT HD domain
HKFIFLAF_02559 2e-73 yabE S 3D domain
HKFIFLAF_02560 2.9e-176 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
HKFIFLAF_02562 0.0 ppc 4.1.1.31 C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HKFIFLAF_02563 1.5e-20
HKFIFLAF_02564 2.7e-20 V COG0577 ABC-type antimicrobial peptide transport system, permease component
HKFIFLAF_02565 4.9e-165 lytR_1 K May catalyze the final step in cell wall teichoic acid biosynthesis, the transfer of the anionic cell wall polymers (APs) from their lipid-linked precursor to the cell wall peptidoglycan (PG)
HKFIFLAF_02566 4.4e-123 yhcW 5.4.2.6 S hydrolase
HKFIFLAF_02567 2.3e-157 cyoA 1.10.3.10, 1.10.3.12 C Catalyzes quinol oxidation with the concomitant reduction of oxygen to water. Subunit II transfers the electrons from a quinol to the binuclear center of the catalytic subunit I
HKFIFLAF_02568 0.0 qoxB 1.10.3.12, 1.9.3.1 C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HKFIFLAF_02569 5.2e-110 cyoC 1.10.3.12, 1.9.3.1 C quinol oxidase, subunit
HKFIFLAF_02570 3e-28 qoxD 1.10.3.12, 1.9.3.1 C quinol oxidase, subunit
HKFIFLAF_02571 4.5e-132 IQ Short-chain dehydrogenase reductase sdr
HKFIFLAF_02572 5.4e-147 tagH 3.6.3.38, 3.6.3.40 GM Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system
HKFIFLAF_02573 3e-84
HKFIFLAF_02574 4.5e-72 3.4.21.121 O Belongs to the peptidase S8 family
HKFIFLAF_02575 0.0 pmmB 5.4.2.2, 5.4.2.8 G Phosphoglucomutase
HKFIFLAF_02576 1.1e-161 yeaB P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HKFIFLAF_02577 5.7e-175 yhfP 1.1.1.1 C Quinone oxidoreductase
HKFIFLAF_02578 7.4e-52 S Iron-sulphur cluster biosynthesis
HKFIFLAF_02579 2.1e-134 gumM 2.4.1.187, 2.4.1.252 GT26,GT4 M Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid
HKFIFLAF_02580 8.3e-09
HKFIFLAF_02581 5.7e-63 S Region found in RelA / SpoT proteins
HKFIFLAF_02582 7.6e-115 K helix_turn_helix, arabinose operon control protein
HKFIFLAF_02583 6.6e-229 G Bacterial extracellular solute-binding protein
HKFIFLAF_02584 9.4e-220 sugA G Binding-protein-dependent transport system inner membrane component
HKFIFLAF_02585 1.9e-147 G Binding-protein-dependent transport system inner membrane component
HKFIFLAF_02586 0.0 treP 2.4.1.64 GH65 G Glycoside hydrolase, family 65
HKFIFLAF_02588 7.2e-217 metC 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
HKFIFLAF_02589 3.4e-216 metB 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
HKFIFLAF_02590 1.1e-175 kdsD 5.3.1.13 M Belongs to the SIS family. GutQ KpsF subfamily
HKFIFLAF_02591 5.6e-155 kdsA 2.5.1.55 M Belongs to the KdsA family
HKFIFLAF_02592 6.6e-69 S Protein of unknown function (DUF2512)
HKFIFLAF_02593 0.0 O Belongs to the peptidase S8 family
HKFIFLAF_02594 2.6e-11 S Protein of unknown function (DUF1659)
HKFIFLAF_02595 9.8e-11 S Protein of unknown function (DUF2922)
HKFIFLAF_02596 2.2e-16 S YvrJ protein family
HKFIFLAF_02597 7.5e-201 EGP Major facilitator Superfamily
HKFIFLAF_02598 6.3e-168 lytR_1 K May catalyze the final step in cell wall teichoic acid biosynthesis, the transfer of the anionic cell wall polymers (APs) from their lipid-linked precursor to the cell wall peptidoglycan (PG)
HKFIFLAF_02600 1.6e-61
HKFIFLAF_02601 1.1e-228 lysN EK COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
HKFIFLAF_02602 2e-121 yvfI K COG2186 Transcriptional regulators
HKFIFLAF_02603 3.5e-230 L PFAM Transposase, IS116 IS110 IS902
HKFIFLAF_02605 3.1e-298 yvfH C L-lactate permease
HKFIFLAF_02606 2.3e-21 S Zinc-ribbon containing domain
HKFIFLAF_02607 3.2e-224 puuP_1 E Amino acid permease
HKFIFLAF_02608 3.5e-163 3.5.1.4 C Acetamidase
HKFIFLAF_02609 6.3e-07 E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HKFIFLAF_02610 3.2e-127 T helix_turn_helix, arabinose operon control protein
HKFIFLAF_02611 1.5e-132 VVA0018 T Histidine kinase
HKFIFLAF_02612 6.7e-37 S double-stranded DNA endodeoxyribonuclease activity
HKFIFLAF_02613 4.9e-110
HKFIFLAF_02615 3.2e-256 rumA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HKFIFLAF_02616 8.5e-167 yfjP 3.2.2.21 L COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HKFIFLAF_02617 6.4e-30 ywqN S NAD(P)H-dependent
HKFIFLAF_02618 1.4e-208 ytmA E COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases
HKFIFLAF_02619 3.4e-42 lrpC K AsnC family transcriptional regulator
HKFIFLAF_02621 3.2e-32 C 4Fe-4S single cluster domain
HKFIFLAF_02622 2.2e-38 2.7.1.199, 2.7.1.208 G phosphotransferase system
HKFIFLAF_02626 4e-08
HKFIFLAF_02627 1.6e-08
HKFIFLAF_02630 4.3e-42 S COG NOG14552 non supervised orthologous group
HKFIFLAF_02632 6.7e-12 K Helix-turn-helix domain, rpiR family
HKFIFLAF_02633 2.3e-164 ygxA S Nucleotidyltransferase-like
HKFIFLAF_02634 7.8e-58 ygzB S UPF0295 protein
HKFIFLAF_02635 2.9e-139 budA 4.1.1.5 Q Alpha-acetolactate decarboxylase
HKFIFLAF_02636 0.0 alsS 2.2.1.6 EH Belongs to the TPP enzyme family
HKFIFLAF_02637 3.1e-164 alsR K LysR substrate binding domain
HKFIFLAF_02638 9.8e-82 perR P Belongs to the Fur family
HKFIFLAF_02639 1.3e-99 yvqK 1.2.1.88, 1.5.5.2, 2.5.1.17 S Adenosyltransferase
HKFIFLAF_02641 3.4e-65 P Ion transport
HKFIFLAF_02642 3.3e-247 gsaB 5.4.3.8 H Glutamate-1-semialdehyde aminotransferase
HKFIFLAF_02643 2.4e-38 yqhV S Protein of unknown function (DUF2619)
HKFIFLAF_02644 8.4e-188 ygaE S Membrane
HKFIFLAF_02645 2.5e-150 K transcriptional
HKFIFLAF_02646 1.1e-249 sacX 2.7.1.201, 2.7.1.211 G phosphotransferase system
HKFIFLAF_02647 1.4e-151 murQ 4.2.1.126 G Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HKFIFLAF_02648 3.3e-208 yleB 4.2.1.126 S Bacterial protein of unknown function (DUF871)
HKFIFLAF_02649 0.0 ygaD V ABC transporter
HKFIFLAF_02650 4.1e-103 ygaC J Belongs to the UPF0374 family
HKFIFLAF_02651 2.3e-35 ygaB S YgaB-like protein
HKFIFLAF_02652 5.1e-10 sspE S Small, acid-soluble spore protein, gamma-type
HKFIFLAF_02653 7.7e-132 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HKFIFLAF_02654 3.8e-165 gltC K Transcriptional regulator
HKFIFLAF_02655 0.0 gltB 1.4.1.13, 1.4.1.14, 1.4.7.1 E glutamate synthase
HKFIFLAF_02656 2.9e-284 gltD 1.4.1.13, 1.4.1.14 E COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases
HKFIFLAF_02657 1.1e-46 S YfzA-like protein
HKFIFLAF_02658 3.5e-101 S ABC-2 family transporter protein
HKFIFLAF_02659 1.9e-158 V ABC transporter
HKFIFLAF_02661 3.1e-22 sspK S reproduction
HKFIFLAF_02662 9.3e-186 yfhP S membrane-bound metal-dependent
HKFIFLAF_02663 3.3e-211 mutY L A G-specific
HKFIFLAF_02664 6.3e-51 yfhH S Protein of unknown function (DUF1811)
HKFIFLAF_02665 2.9e-140 recX 2.4.1.337 GT4 S Modulates RecA activity
HKFIFLAF_02667 5e-24 yfhD S YfhD-like protein
HKFIFLAF_02668 3.4e-138 trpA 4.2.1.20 E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
HKFIFLAF_02670 4.6e-227 trpB 4.2.1.20, 5.3.1.24 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HKFIFLAF_02671 2.5e-248 trpF 4.1.1.48, 4.2.1.160, 4.2.1.20, 5.3.1.24 E Belongs to the TrpC family
HKFIFLAF_02672 5.5e-181 trpD 2.4.2.18, 4.1.3.27 E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HKFIFLAF_02673 3.3e-109 trpG 2.4.2.18, 2.6.1.85, 4.1.3.27 EH Anthranilate synthase
HKFIFLAF_02674 5.6e-261 trpE 4.1.3.27 EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HKFIFLAF_02675 1.3e-48 bacI V COG0577 ABC-type antimicrobial peptide transport system, permease component
HKFIFLAF_02676 0.0 glgP 2.4.1.1 GT35 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
HKFIFLAF_02679 4.6e-240 mcpA NT chemotaxis protein
HKFIFLAF_02680 4.3e-183 serA1 EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HKFIFLAF_02681 4e-220 dhsS 1.12.1.2 E COG0075 Serine-pyruvate aminotransferase archaeal aspartate aminotransferase
HKFIFLAF_02682 1e-301 serA 1.1.1.399, 1.1.1.95 E Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HKFIFLAF_02683 3e-179 S Phosphotransferase system, EIIC
HKFIFLAF_02684 2.4e-217 2.6.1.9 S HAD-hyrolase-like
HKFIFLAF_02685 5.7e-189 ilvA 4.3.1.19 E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HKFIFLAF_02686 2.3e-110 leuD 4.2.1.33, 4.2.1.35, 4.2.1.36 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HKFIFLAF_02687 4e-270 leuC 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HKFIFLAF_02688 2e-197 leuB 1.1.1.85 CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
HKFIFLAF_02689 1.7e-282 leuA 2.3.3.13 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HKFIFLAF_02690 2.6e-194 ilvC 1.1.1.86 EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HKFIFLAF_02691 1.1e-84 ilvN 2.2.1.6 E Acetolactate synthase
HKFIFLAF_02692 0.0 ilvB 2.2.1.6 E Acetolactate synthase
HKFIFLAF_02693 0.0 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
HKFIFLAF_02694 1.1e-242 braB E Component of the transport system for branched-chain amino acids
HKFIFLAF_02695 1.6e-152 T STAS domain
HKFIFLAF_02696 2.1e-246
HKFIFLAF_02697 1.6e-37 cypC 1.11.2.4, 1.14.14.1 Q Cytochrome P450
HKFIFLAF_02698 2.6e-104 yetJ S Belongs to the BI1 family
HKFIFLAF_02699 1.5e-216 yxjG 2.1.1.14 E Methionine synthase
HKFIFLAF_02700 9.5e-220 yhjX P Major facilitator superfamily
HKFIFLAF_02701 2.1e-137 ypdB KT LytTr DNA-binding domain
HKFIFLAF_02702 3.4e-308 ypdA 2.7.13.3 T Signal transduction histidine kinase
HKFIFLAF_02703 1.2e-191 ansA 3.5.1.1 EJ L-asparaginase
HKFIFLAF_02704 2.8e-261 cotA 1.10.3.4, 1.16.3.3 Q multicopper oxidases
HKFIFLAF_02705 6.8e-75 yhgD K Transcriptional regulator
HKFIFLAF_02706 3e-155 yhgE S YhgE Pip N-terminal domain protein
HKFIFLAF_02707 7.9e-225 S Protein of unknown function N-terminus (DUF3323)
HKFIFLAF_02708 0.0 D Putative exonuclease SbcCD, C subunit
HKFIFLAF_02709 8.6e-231 S Protein of unknown function (DUF2398)
HKFIFLAF_02711 4e-249 S Protein of unknown function (DUF2397)
HKFIFLAF_02712 2.4e-145 yoaT S Protein of unknown function (DUF817)
HKFIFLAF_02713 5.1e-28 yozG K Transcriptional regulator
HKFIFLAF_02714 9.3e-70 yoaS S Protein of unknown function (DUF2975)
HKFIFLAF_02715 2.1e-42
HKFIFLAF_02716 9.6e-237 ydjN U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
HKFIFLAF_02717 3.3e-75 yqgC S protein conserved in bacteria
HKFIFLAF_02718 8e-274 ydbT S Bacterial PH domain
HKFIFLAF_02719 2.7e-85 S Bacterial PH domain
HKFIFLAF_02720 4.3e-86 S AAA domain
HKFIFLAF_02721 6.2e-31 yhcC S nucleic-acid-binding protein containing a Zn-ribbon domain
HKFIFLAF_02722 3.4e-188 yfjN J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HKFIFLAF_02723 4.3e-64 argO S Lysine exporter protein LysE YggA
HKFIFLAF_02724 4.3e-298 lmrA 3.6.3.44 V ABC transporter
HKFIFLAF_02725 1.1e-99 K DNA-binding transcription factor activity
HKFIFLAF_02726 1.2e-169
HKFIFLAF_02727 2.7e-68
HKFIFLAF_02728 1.7e-219 S 50S ribosome-binding GTPase
HKFIFLAF_02729 8.3e-256 era S 50S ribosome-binding GTPase
HKFIFLAF_02730 5.9e-91
HKFIFLAF_02731 8.5e-100 sodA 1.15.1.1 P Superoxide dismutase
HKFIFLAF_02732 1.8e-61 L DDE superfamily endonuclease
HKFIFLAF_02735 2.9e-47 L Transposase
HKFIFLAF_02736 1.4e-61 tcaA S response to antibiotic
HKFIFLAF_02737 2.3e-20 ycdA S Domain of unknown function (DUF4352)
HKFIFLAF_02738 2.4e-36 ycdA S Domain of unknown function (DUF4352)
HKFIFLAF_02741 2.2e-63 erpA S Belongs to the HesB IscA family
HKFIFLAF_02742 1.1e-59 yuzD S protein conserved in bacteria
HKFIFLAF_02743 8.6e-37 nifU O COG0694 Thioredoxin-like proteins and domains
HKFIFLAF_02744 2.4e-200 yutH S Spore coat protein
HKFIFLAF_02745 4.8e-85 pgpA 3.1.3.27 I COG1267 Phosphatidylglycerophosphatase A and related proteins
HKFIFLAF_02746 3.3e-07 pgpA 3.1.3.27 I COG1267 Phosphatidylglycerophosphatase A and related proteins
HKFIFLAF_02747 9.6e-138 nagD 2.7.1.25, 3.1.3.41 G Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
HKFIFLAF_02748 4.3e-74 yutE S Protein of unknown function DUF86
HKFIFLAF_02749 1.5e-48 yutD S protein conserved in bacteria
HKFIFLAF_02750 1e-173 lipA 2.8.1.8 H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HKFIFLAF_02751 3.4e-196 lytH M Peptidase, M23
HKFIFLAF_02752 9.4e-127 yunB S Sporulation protein YunB (Spo_YunB)
HKFIFLAF_02753 3.7e-48 yunC S Domain of unknown function (DUF1805)
HKFIFLAF_02754 2.6e-277 yunD 3.1.3.5 F Belongs to the 5'-nucleotidase family
HKFIFLAF_02755 2.2e-273 sufB O FeS cluster assembly
HKFIFLAF_02756 3.2e-77 nifU C COG0822 NifU homolog involved in Fe-S cluster formation
HKFIFLAF_02757 5.9e-238 sufS 2.8.1.7, 4.4.1.16 E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HKFIFLAF_02758 8.8e-240 sufD O assembly protein SufD
HKFIFLAF_02759 5.1e-142 sufC O COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component
HKFIFLAF_02761 1.5e-49 traF CO Thioredoxin
HKFIFLAF_02762 5.1e-63 gcvH E Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate
HKFIFLAF_02763 7.4e-64 arsC 1.20.4.1 P Belongs to the ArsC family
HKFIFLAF_02764 0.0 fadE 1.3.8.1 I acyl-CoA dehydrogenase
HKFIFLAF_02765 1.1e-214 fadA 2.3.1.16 I Belongs to the thiolase family
HKFIFLAF_02766 0.0 fadB 1.1.1.35, 4.2.1.17, 5.1.2.3 I 3-hydroxyacyl-CoA dehydrogenase
HKFIFLAF_02767 2.6e-14 S YuzL-like protein
HKFIFLAF_02768 2.4e-40
HKFIFLAF_02769 1.3e-54 yusN M Coat F domain
HKFIFLAF_02770 2.9e-213 rodA D Belongs to the SEDS family
HKFIFLAF_02771 1.3e-69 ydbP 2.7.1.180, 5.3.4.1 CO Thioredoxin
HKFIFLAF_02772 2.8e-279 cls2 I PLD-like domain
HKFIFLAF_02774 0.0 swrC V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HKFIFLAF_02775 1.2e-191 M1-600 T Putative diguanylate phosphodiesterase
HKFIFLAF_02776 8.1e-298 katA 1.11.1.6 P serves to protect cells from the toxic effects of hydrogen peroxide
HKFIFLAF_02777 1.2e-100 bcrC 3.6.1.27 I COG0671 Membrane-associated phospholipid phosphatase
HKFIFLAF_02778 2.9e-139 pgdA 3.5.1.104, 3.5.1.41 G Polysaccharide deacetylase
HKFIFLAF_02779 5.2e-245 ugtP 2.4.1.315 GT28 M Monogalactosyldiacylglycerol (MGDG) synthase
HKFIFLAF_02780 3.4e-123
HKFIFLAF_02781 2.6e-83 S Putative zinc-finger
HKFIFLAF_02782 2.2e-88 K Belongs to the sigma-70 factor family. ECF subfamily
HKFIFLAF_02783 1.3e-221 ykoN 2.4.1.315 GT28 M COG0707 UDP-N-acetylglucosamine LPS N-acetylglucosamine transferase
HKFIFLAF_02784 0.0 M Dolichyl-phosphate-mannose-protein mannosyltransferase
HKFIFLAF_02785 4.1e-242 NU cell adhesion
HKFIFLAF_02787 3.9e-259 L Mu transposase, C-terminal
HKFIFLAF_02788 8e-151 U AAA domain
HKFIFLAF_02790 3.7e-182 bioB 2.8.1.6 H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HKFIFLAF_02791 3.7e-30 L helicase
HKFIFLAF_02792 0.0 L helicase
HKFIFLAF_02793 2.9e-95 L helicase
HKFIFLAF_02795 6.3e-18
HKFIFLAF_02796 1.2e-22
HKFIFLAF_02797 5.7e-10 S transposase or invertase
HKFIFLAF_02798 1.1e-80 smpB O Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HKFIFLAF_02799 0.0 rnr K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
HKFIFLAF_02800 1.3e-142 est 3.1.1.1 S Carboxylesterase
HKFIFLAF_02801 2.5e-28 secG U Preprotein translocase subunit SecG
HKFIFLAF_02802 5.4e-242 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
HKFIFLAF_02804 1.1e-302 gpmI 5.4.2.12 G Catalyzes the interconversion of 2-phosphoglycerate and
HKFIFLAF_02805 1.1e-122 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
HKFIFLAF_02806 1e-218 pgk 2.7.2.3, 5.3.1.1 F Belongs to the phosphoglycerate kinase family
HKFIFLAF_02807 6.9e-184 gapA 1.2.1.12 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
HKFIFLAF_02808 1.4e-184 cggR K COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain
HKFIFLAF_02809 9.5e-38 XAC3035 O Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HKFIFLAF_02810 7.1e-245 rpoN K COG1508 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog
HKFIFLAF_02812 1.3e-07 S Heavy-metal-associated domain
HKFIFLAF_02813 3.4e-83 S Protein of unknown function (DUF1641)
HKFIFLAF_02815 0.0 yjgC 1.17.1.10, 1.17.1.9 C formate dehydrogenase, alpha subunit
HKFIFLAF_02816 1.7e-31
HKFIFLAF_02818 1.5e-14 S transposase or invertase
HKFIFLAF_02819 0.0 pbp2A 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
HKFIFLAF_02820 1.4e-84 uspF T Universal stress protein
HKFIFLAF_02822 5.3e-192 ykfD E Belongs to the ABC transporter superfamily
HKFIFLAF_02823 1.5e-177 ykfC 3.4.14.13 M COG0791 Cell wall-associated hydrolases (invasion-associated proteins)
HKFIFLAF_02824 0.0 dppE E ABC transporter substrate-binding protein
HKFIFLAF_02825 1.6e-188 dppD P Belongs to the ABC transporter superfamily
HKFIFLAF_02826 1.5e-167 dppC EP COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
HKFIFLAF_02827 2.2e-160 dppB P COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
HKFIFLAF_02828 3.2e-127 S Peptidase C26
HKFIFLAF_02829 8.5e-184 corA P Mediates influx of magnesium ions
HKFIFLAF_02830 1.8e-46 yhdB S YhdB-like protein
HKFIFLAF_02832 6.7e-278 ycgB S Stage V sporulation protein R
HKFIFLAF_02833 3e-184 ykrP G COG3594 Fucose 4-O-acetylase and related acetyltransferases
HKFIFLAF_02834 9.1e-135 3.2.1.18 GH33 E GDSL-like Lipase/Acylhydrolase
HKFIFLAF_02835 1.9e-74 bdbC O Required for disulfide bond formation in some proteins
HKFIFLAF_02836 1.4e-86 bdbA CO Thioredoxin
HKFIFLAF_02837 1.3e-66 yhcU S Family of unknown function (DUF5365)
HKFIFLAF_02838 4.5e-35 S PFAM Uncharacterised protein family UPF0236
HKFIFLAF_02839 7.5e-85 2.3.1.57 K Acetyltransferase (GNAT) domain
HKFIFLAF_02841 2.6e-61 S Psort location CytoplasmicMembrane, score
HKFIFLAF_02842 4.1e-150 S Psort location CytoplasmicMembrane, score
HKFIFLAF_02843 5.9e-120 yfiR K Transcriptional regulator
HKFIFLAF_02844 4.5e-225 yfiS EGP Major facilitator Superfamily
HKFIFLAF_02845 9.6e-138 thiX 2.7.1.50 P binding-protein-dependent transport systems inner membrane component
HKFIFLAF_02846 5.5e-178 nrtA P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components
HKFIFLAF_02847 9.5e-18 S Glyoxalase bleomycin resistance protein dioxygenase
HKFIFLAF_02848 2.3e-74 S Glyoxalase bleomycin resistance protein dioxygenase
HKFIFLAF_02849 1.5e-113 yitD 4.4.1.19 S synthase
HKFIFLAF_02850 2.9e-125 comB 3.1.3.71 H Belongs to the ComB family
HKFIFLAF_02851 0.0 cysJ 1.8.1.2 P Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HKFIFLAF_02852 0.0 cysI 1.7.7.1, 1.8.1.2, 1.8.7.1 P Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate
HKFIFLAF_02853 1.9e-104
HKFIFLAF_02854 9.1e-81 mta K transcriptional
HKFIFLAF_02855 3.6e-09 mta K transcriptional
HKFIFLAF_02857 5e-14 dapE 3.5.1.16, 3.5.1.18 E Peptidase dimerisation domain
HKFIFLAF_02858 1.3e-248 dapE 3.5.1.16, 3.5.1.18 E Peptidase dimerisation domain
HKFIFLAF_02859 2.2e-179 yjlA EG Putative multidrug resistance efflux transporter
HKFIFLAF_02860 2.9e-187 acoA C COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
HKFIFLAF_02861 1.1e-189 acoB C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
HKFIFLAF_02862 6.1e-211 acoC 2.3.1.12, 2.3.1.61 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
HKFIFLAF_02863 2.1e-260 acoL 1.8.1.4 C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
HKFIFLAF_02864 0.0 acoR KQ COG3284 Transcriptional activator of acetoin glycerol metabolism
HKFIFLAF_02865 4.8e-180 kefA M Mechanosensitive ion channel
HKFIFLAF_02866 5.6e-191 S COG0491 Zn-dependent hydrolases, including glyoxylases
HKFIFLAF_02867 1e-54 I SCP-2 sterol transfer family
HKFIFLAF_02868 2.2e-102 S Appr-1'-p processing enzyme
HKFIFLAF_02869 4.4e-25 sspH S small acid-soluble spore protein
HKFIFLAF_02870 7.8e-132 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
HKFIFLAF_02871 6.6e-53 6.2.1.3 IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
HKFIFLAF_02872 4.3e-62 rtp K Plays a role in DNA replication and termination (fork arrest mechanism). Two dimers of rtp bind to the two inverted repeat regions (IRI and IRII) present in the termination site. The binding of each dimer is centered on an 8 bp direct repeat
HKFIFLAF_02873 6.1e-143 S Sucrose-6F-phosphate phosphohydrolase
HKFIFLAF_02874 1.3e-102 yozB S membrane
HKFIFLAF_02875 2e-59
HKFIFLAF_02876 9.5e-75 mltG S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HKFIFLAF_02877 4.5e-180 ldh1 1.1.1.27 C Belongs to the LDH MDH superfamily
HKFIFLAF_02878 1e-128 IQ Enoyl-(Acyl carrier protein) reductase
HKFIFLAF_02879 1.4e-215 fsr P COG0477 Permeases of the major facilitator superfamily
HKFIFLAF_02880 2.8e-78 sleB 3.5.1.28 M Cell wall
HKFIFLAF_02881 7.8e-148 xth 3.1.11.2 L exodeoxyribonuclease III
HKFIFLAF_02882 1.9e-153 1.1.1.31, 1.1.1.60 I COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases
HKFIFLAF_02883 5.9e-282 glgA 2.4.1.21 GT5 G Synthesizes alpha-1,4-glucan chains using ADP-glucose
HKFIFLAF_02884 7.5e-192 glgD 2.4.1.21, 2.7.7.27 GT5 G Glucose-1-phosphate adenylyltransferase, GlgD subunit
HKFIFLAF_02885 2.9e-210 glgC 2.7.7.27 G Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HKFIFLAF_02886 0.0 glgB 2.4.1.18, 3.2.1.141, 3.2.1.20 CBM48,GH13,GH31 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HKFIFLAF_02887 2.4e-197 G Glycosyl hydrolases family 15
HKFIFLAF_02888 1.1e-21 S YpzG-like protein
HKFIFLAF_02889 9.4e-81 Q protein disulfide oxidoreductase activity
HKFIFLAF_02890 2.1e-88 ywnH 2.3.1.183 M COG1247 Sortase and related acyltransferases
HKFIFLAF_02891 1.1e-118 nudL L COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
HKFIFLAF_02892 3e-224 mntH P H( )-stimulated, divalent metal cation uptake system
HKFIFLAF_02893 1.1e-75 dps P Ferritin-like domain
HKFIFLAF_02894 7.3e-80 V VanZ like family
HKFIFLAF_02895 1.5e-169 yhcI S ABC-2 family transporter protein
HKFIFLAF_02896 8.1e-171 ydbJ V ABC transporter, ATP-binding protein
HKFIFLAF_02897 6.3e-57
HKFIFLAF_02898 6.9e-167 murB 1.3.1.98 M cell wall formation
HKFIFLAF_02899 2.3e-87 S Protein of unknown function (DUF1189)
HKFIFLAF_02900 1.4e-37 S Protein of unknown function (DUF1450)
HKFIFLAF_02901 7.9e-271 gnd 1.1.1.343, 1.1.1.44 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HKFIFLAF_02902 1.3e-55 I MaoC like domain
HKFIFLAF_02904 7.8e-199 selU S tRNA 2-selenouridine synthase
HKFIFLAF_02905 7.6e-194 selD 2.7.9.3 E Synthesizes selenophosphate from selenide and ATP
HKFIFLAF_02906 1.4e-135 T Calcineurin-like phosphoesterase superfamily domain
HKFIFLAF_02907 9.6e-190 yraQ S Predicted permease
HKFIFLAF_02908 1.3e-229 proA 1.2.1.41, 1.2.1.81 E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HKFIFLAF_02909 5e-196 proB 2.7.2.11 E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HKFIFLAF_02910 6.4e-73 yjlC S Protein of unknown function (DUF1641)
HKFIFLAF_02911 2e-219 yjlD 1.6.99.3 C NADH dehydrogenase
HKFIFLAF_02912 3.1e-228 nrnB S phosphohydrolase (DHH superfamily)
HKFIFLAF_02913 9.9e-126 rpiA 2.7.1.12, 2.7.1.15, 5.3.1.6 G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HKFIFLAF_02914 8.8e-130 yvpB NU protein conserved in bacteria
HKFIFLAF_02915 2.4e-50 tnrA K transcriptional
HKFIFLAF_02916 4.2e-109 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
HKFIFLAF_02917 1.9e-23 S Virus attachment protein p12 family
HKFIFLAF_02918 0.0 feoB P transporter of a GTP-driven Fe(2 ) uptake system
HKFIFLAF_02919 2.4e-36 feoA P COG1918 Fe2 transport system protein A
HKFIFLAF_02920 3.6e-224 dapL 2.6.1.83 E Aminotransferase
HKFIFLAF_02921 1.2e-263 argH 4.3.2.1 E argininosuccinate lyase
HKFIFLAF_02922 6.2e-232 argG 6.3.4.5 E Belongs to the argininosuccinate synthase family. Type 1 subfamily
HKFIFLAF_02923 5.3e-178 argF 2.1.3.3 E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HKFIFLAF_02924 0.0 carB 6.3.5.5 EF Carbamoyl-phosphate synthetase ammonia chain
HKFIFLAF_02925 1.5e-205 carA 6.3.5.5 F Carbamoyl-phosphate synthetase glutamine chain
HKFIFLAF_02926 3.6e-224 argD 2.6.1.11, 2.6.1.17 E acetylornithine aminotransferase
HKFIFLAF_02927 1.3e-140 argB 2.7.2.8 E Belongs to the acetylglutamate kinase family. ArgB subfamily
HKFIFLAF_02928 4.9e-232 argJ 2.3.1.1, 2.3.1.35, 2.7.2.8 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HKFIFLAF_02929 3.9e-198 argC 1.2.1.38 E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HKFIFLAF_02931 1.3e-81
HKFIFLAF_02932 1.3e-30 P catalase activity
HKFIFLAF_02933 8.1e-210 L Transposase
HKFIFLAF_02934 8.2e-64 L Transposase IS200 like
HKFIFLAF_02935 4.3e-80
HKFIFLAF_02936 2.3e-30 cspD K Cold shock
HKFIFLAF_02938 3.2e-172 3.4.17.13 V proteins, homologs of microcin C7 resistance protein MccF
HKFIFLAF_02939 1.1e-278 dacC 3.4.16.4 M D-alanyl-D-alanine carboxypeptidase
HKFIFLAF_02940 6.3e-105 plsC 2.3.1.51 I Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family
HKFIFLAF_02941 6.2e-76 yneK S Protein of unknown function (DUF2621)
HKFIFLAF_02942 4.6e-77 yneJ O COG4846 Membrane protein involved in cytochrome C biogenesis
HKFIFLAF_02943 3.4e-164 ytnM S membrane transporter protein
HKFIFLAF_02945 2.2e-238 E COG1113 Gamma-aminobutyrate permease and related permeases
HKFIFLAF_02946 1.8e-136 nfrA 1.5.1.38, 1.5.1.39 C Oxidoreductase
HKFIFLAF_02948 3.7e-48 ureA 3.5.1.5 E Belongs to the urease gamma subunit family
HKFIFLAF_02949 6.7e-56 ureB 3.5.1.5 E Belongs to the urease beta subunit family
HKFIFLAF_02950 0.0 ureC 3.5.1.5 E Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family
HKFIFLAF_02951 6e-79 ureE O Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HKFIFLAF_02952 1.1e-103 ureF O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
HKFIFLAF_02953 2.8e-111 ureG KO Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HKFIFLAF_02954 1.5e-157 ureD O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
HKFIFLAF_02955 7.9e-112 ureH S PFAM Nickel cobalt transporter, high-affinity
HKFIFLAF_02956 3.9e-174 pfoS S Phosphotransferase system, EIIC
HKFIFLAF_02957 6.6e-190 dhaK 2.7.1.121, 2.7.1.28, 2.7.1.29, 4.6.1.15 G Dihydroxyacetone kinase DhaK, subunit
HKFIFLAF_02958 3.3e-101 dhaL 2.7.1.121 S Dak2
HKFIFLAF_02959 5.8e-59 dhaM 2.7.1.121 S PTS system fructose IIA component
HKFIFLAF_02960 9.7e-250 gabT 2.6.1.19, 2.6.1.22 E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HKFIFLAF_02961 6.8e-136 ywaC 2.7.6.5 S protein conserved in bacteria
HKFIFLAF_02962 7.6e-71 ywnF S Family of unknown function (DUF5392)
HKFIFLAF_02964 2.2e-204 rlmN 2.1.1.192 J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HKFIFLAF_02965 5.6e-254 iolT EGP Major facilitator Superfamily
HKFIFLAF_02966 2.3e-84 G phosphoenolpyruvate-dependent sugar phosphotransferase system
HKFIFLAF_02967 3.5e-57 ygbA S Nitrous oxide-stimulated promoter
HKFIFLAF_02968 2.5e-152 yidA S hydrolases of the HAD superfamily
HKFIFLAF_02969 8.2e-32
HKFIFLAF_02970 6.6e-93 D Hemerythrin HHE cation binding
HKFIFLAF_02971 1.1e-203 gldA 1.1.1.6 C COG0371 Glycerol dehydrogenase and related enzymes
HKFIFLAF_02972 3.5e-132 fruR K Transcriptional regulator
HKFIFLAF_02973 0.0 fruA 2.7.1.202 GT COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type)
HKFIFLAF_02974 0.0 yjcE P COG0025 NhaP-type Na H and K H antiporters
HKFIFLAF_02975 6e-35 yoeD G Helix-turn-helix domain
HKFIFLAF_02976 5.1e-119 nanE 5.1.3.9 G Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HKFIFLAF_02977 1.2e-210 fni 5.3.3.2 C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
HKFIFLAF_02979 1.2e-88 1.8.5.2 S DoxX
HKFIFLAF_02981 4e-107 C Nitroreductase family
HKFIFLAF_02982 0.0 snf 2.7.11.1 L COG0553 Superfamily II DNA RNA helicases, SNF2 family
HKFIFLAF_02983 5.8e-143 cas6 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA)
HKFIFLAF_02984 0.0
HKFIFLAF_02985 8.5e-184 cas7 L CRISPR-associated protein Cas7
HKFIFLAF_02986 4.3e-129 cas5 L TIGRFAM CRISPR-associated protein Cas5
HKFIFLAF_02987 0.0 L Metal dependent phosphohydrolases with conserved 'HD' motif.
HKFIFLAF_02988 5.7e-94 cas4 3.1.12.1 L TIGRFAM CRISPR-associated protein Cas4
HKFIFLAF_02989 3.3e-154 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HKFIFLAF_02990 5.8e-42 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HKFIFLAF_02991 2.1e-261 L Transposase, IS4 family protein
HKFIFLAF_02992 2.3e-72 K sequence-specific DNA binding
HKFIFLAF_02993 5.8e-117 cobC 3.1.3.3, 3.1.3.73, 5.4.2.12 G Histidine phosphatase superfamily (branch 1)
HKFIFLAF_02994 1.8e-224 gltP C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
HKFIFLAF_02995 3.2e-222 cpdB 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
HKFIFLAF_02996 3.1e-153 K RpiR family transcriptional regulator
HKFIFLAF_02997 1.8e-143 ypuA S Secreted protein
HKFIFLAF_02998 1.3e-104
HKFIFLAF_02999 3.1e-69 S response to pH
HKFIFLAF_03000 1e-105 che
HKFIFLAF_03001 5.6e-294 K helix_turn_helix, Lux Regulon
HKFIFLAF_03003 6.9e-119 3.5.1.28 M n-acetylmuramoyl-L-alanine amidase
HKFIFLAF_03004 2.8e-102 4.2.1.1 P Reversible hydration of carbon dioxide
HKFIFLAF_03005 1.6e-117 yrrT 4.4.1.21 Q Could be a S-adenosyl-L-methionine-dependent methyltransferase
HKFIFLAF_03006 6.2e-87 luxS 4.4.1.21 T Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
HKFIFLAF_03007 2.5e-169 mccA 2.5.1.134, 2.5.1.47 E Cysteine synthase
HKFIFLAF_03008 1e-212 mccB 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
HKFIFLAF_03009 2.5e-90 yuaF OU Membrane protein implicated in regulation of membrane protease activity
HKFIFLAF_03010 1.7e-170 yuaG S protein conserved in bacteria
HKFIFLAF_03011 2.2e-182 mreB D Rod-share determining protein MreBH
HKFIFLAF_03012 1.3e-85 ykhA 3.1.2.20 I Acyl-CoA hydrolase
HKFIFLAF_03013 1.3e-145 dksA T COG1734 DnaK suppressor protein
HKFIFLAF_03014 3.9e-229 EGP Major facilitator Superfamily
HKFIFLAF_03015 1.9e-49 yeaO S Protein of unknown function, DUF488
HKFIFLAF_03017 1.3e-57 yhdN S Domain of unknown function (DUF1992)
HKFIFLAF_03018 1.5e-136 motA N flagellar motor
HKFIFLAF_03019 1.9e-139 motB N Flagellar motor protein
HKFIFLAF_03020 1.6e-91 yfkM 3.5.1.124 S protease
HKFIFLAF_03021 1.7e-142 map 3.4.11.18 E Methionine aminopeptidase
HKFIFLAF_03022 7.3e-33 yfkK S Belongs to the UPF0435 family
HKFIFLAF_03023 3.9e-148 yihY S Belongs to the UPF0761 family
HKFIFLAF_03024 1.8e-220 yfkF EGP Major facilitator Superfamily
HKFIFLAF_03025 1.1e-171 cax P COG0387 Ca2 H antiporter
HKFIFLAF_03026 9e-147 yfkD S YfkD-like protein
HKFIFLAF_03027 4.4e-26 yfjT
HKFIFLAF_03028 2.8e-148 pdaA G deacetylase

eggNOG-mapper v2 (Database: eggNOG v5.0, Jul. 2018 release)