ORF_ID e_value Gene_name EC_number CAZy COGs Description
CCEKOFMD_00001 1.3e-137 L Transposase
CCEKOFMD_00002 0.0 ftsH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CCEKOFMD_00003 3.4e-97 hpt 2.4.2.8, 6.3.4.19 F Belongs to the purine pyrimidine phosphoribosyltransferase family
CCEKOFMD_00004 5e-240 tilS 2.4.2.8, 6.3.4.19 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
CCEKOFMD_00005 1.3e-240 XK27_09285 3.5.2.6 V Beta-lactamase enzyme family
CCEKOFMD_00007 2.7e-61 divIC D Septum formation initiator
CCEKOFMD_00008 1.7e-39 yabO J Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
CCEKOFMD_00009 0.0 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CCEKOFMD_00010 1.4e-104 pth 3.1.1.29 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
CCEKOFMD_00011 1.6e-202 ychF J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
CCEKOFMD_00012 1.1e-29 yyzM S Protein conserved in bacteria
CCEKOFMD_00013 6.3e-202 dnaN 2.7.7.7 L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
CCEKOFMD_00014 1.3e-257 dnaA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CCEKOFMD_00015 8.5e-134 parB K Belongs to the ParB family
CCEKOFMD_00016 1.1e-196 htrA 3.4.21.107 O Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain'
CCEKOFMD_00017 1.1e-86 rlmH 2.1.1.177 J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CCEKOFMD_00018 6.2e-120 yoaK S Psort location CytoplasmicMembrane, score
CCEKOFMD_00022 0.0 XK27_10405 S Bacterial membrane protein YfhO
CCEKOFMD_00023 3.3e-305 ybiT S abc transporter atp-binding protein
CCEKOFMD_00024 4.2e-153 yvjA S membrane
CCEKOFMD_00025 3.1e-192 trpS 6.1.1.2 J Tryptophanyl-tRNA synthetase
CCEKOFMD_00026 4.3e-275 guaB 1.1.1.205 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
CCEKOFMD_00027 5.9e-205 recF L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CCEKOFMD_00028 1.6e-45 yaaA S S4 domain protein YaaA
CCEKOFMD_00029 4.8e-235 ymfF S Peptidase M16
CCEKOFMD_00030 3.1e-242 ymfH S Peptidase M16
CCEKOFMD_00031 6.3e-138 ymfM S sequence-specific DNA binding
CCEKOFMD_00032 3.1e-90 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CCEKOFMD_00033 1.5e-152 ecfA1 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CCEKOFMD_00034 5.2e-153 ecfA2 3.6.3.55 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CCEKOFMD_00035 1e-137 ecfT P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CCEKOFMD_00036 1.7e-91 lytE M LysM domain protein
CCEKOFMD_00037 9.9e-64 isaA GH23 M Immunodominant staphylococcal antigen A
CCEKOFMD_00038 0.0 S Bacterial membrane protein, YfhO
CCEKOFMD_00039 4.3e-219 mnmA 2.8.1.13 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
CCEKOFMD_00040 1.5e-77 F NUDIX domain
CCEKOFMD_00041 0.0 gidA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
CCEKOFMD_00042 0.0 yybT T signaling protein consisting of a modified GGDEF domain and a DHH domain
CCEKOFMD_00043 3.9e-70 rplI J binds to the 23S rRNA
CCEKOFMD_00044 1.5e-245 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
CCEKOFMD_00045 8.2e-48 veg S Biofilm formation stimulator VEG
CCEKOFMD_00046 2.9e-108 rpsD J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CCEKOFMD_00047 6.4e-141 sip L Phage integrase, N-terminal SAM-like domain
CCEKOFMD_00048 1.4e-12 K sequence-specific DNA binding
CCEKOFMD_00049 3.4e-12 K Helix-turn-helix
CCEKOFMD_00050 6.7e-17
CCEKOFMD_00051 3.8e-13
CCEKOFMD_00052 6.5e-266
CCEKOFMD_00058 2.8e-27 S Transcriptional regulator, RinA family
CCEKOFMD_00059 4.4e-18 yjgN S membrane
CCEKOFMD_00062 2e-53 ypaA S membrane
CCEKOFMD_00063 6.4e-96 XK27_06935 K transcriptional regulator
CCEKOFMD_00064 3.9e-161 XK27_06930 V domain protein
CCEKOFMD_00065 1.8e-88 S Putative adhesin
CCEKOFMD_00066 1.8e-19 XK27_06920 S Protein of unknown function (DUF1700)
CCEKOFMD_00068 1.7e-23 K negative regulation of transcription, DNA-templated
CCEKOFMD_00069 4e-19 K negative regulation of transcription, DNA-templated
CCEKOFMD_00070 3.4e-13 nudL L hydrolase
CCEKOFMD_00071 1.1e-11 K CsbD-like
CCEKOFMD_00072 3.1e-85 M Protein conserved in bacteria
CCEKOFMD_00073 1.8e-23 S Small integral membrane protein
CCEKOFMD_00074 9.1e-101
CCEKOFMD_00075 1e-29 S Membrane
CCEKOFMD_00077 2.5e-96 S Hydrophobic domain protein
CCEKOFMD_00078 1.5e-49 yegS 2.7.1.107 I lipid kinase activity
CCEKOFMD_00081 1.4e-221 sip L Belongs to the 'phage' integrase family
CCEKOFMD_00082 1.4e-21 S MerR HTH family regulatory protein
CCEKOFMD_00083 2.8e-111 S Plasmid replication protein
CCEKOFMD_00084 1.2e-40
CCEKOFMD_00085 7.4e-184 D COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins
CCEKOFMD_00086 6.8e-45
CCEKOFMD_00087 1.9e-30
CCEKOFMD_00088 5.4e-121
CCEKOFMD_00089 7.4e-87 2.7.11.1 K nucleotide-binding Protein
CCEKOFMD_00090 4.6e-64 V Restriction endonuclease
CCEKOFMD_00091 8e-191 L DNA restriction-modification system
CCEKOFMD_00092 1.1e-236 L Helix-turn-helix domain of transposase family ISL3
CCEKOFMD_00093 6.7e-19 rpmG J Belongs to the bacterial ribosomal protein bL33 family
CCEKOFMD_00094 1e-24 rpmF J Belongs to the bacterial ribosomal protein bL32 family
CCEKOFMD_00095 1.4e-36 metE 2.1.1.14 E Methionine synthase
CCEKOFMD_00096 5.2e-55 metE 2.1.1.14 E Methionine synthase
CCEKOFMD_00097 1.4e-53 metE 2.1.1.14 E Methionine synthase
CCEKOFMD_00098 1.6e-241 hisS 6.1.1.21 J histidyl-tRNA synthetase
CCEKOFMD_00100 0.0 aspS 6.1.1.12 J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
CCEKOFMD_00101 9.3e-167 XK27_01785 S cog cog1284
CCEKOFMD_00102 7e-147 yaaA S Belongs to the UPF0246 family
CCEKOFMD_00103 3.7e-116 nrdG 1.97.1.4 O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CCEKOFMD_00104 1.7e-90 XK27_10930 K acetyltransferase
CCEKOFMD_00105 7.5e-14
CCEKOFMD_00106 0.0 nrdD 1.1.98.6 F Ribonucleoside-triphosphate reductase
CCEKOFMD_00107 2.8e-299 ccs S the current gene model (or a revised gene model) may contain a frame shift
CCEKOFMD_00108 4.2e-44 yrzB S Belongs to the UPF0473 family
CCEKOFMD_00109 1.2e-70 yqgF L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CCEKOFMD_00110 2.2e-44 yrzL S Belongs to the UPF0297 family
CCEKOFMD_00111 5.5e-26 rpmB J Belongs to the bacterial ribosomal protein bL28 family
CCEKOFMD_00112 7.5e-236 rarA L ATPase related to the helicase subunit of the Holliday junction resolvase
CCEKOFMD_00114 2.2e-132 int L Belongs to the 'phage' integrase family
CCEKOFMD_00115 2.5e-89 K sequence-specific DNA binding
CCEKOFMD_00116 1.1e-286 V ABC transporter transmembrane region
CCEKOFMD_00117 6.3e-159 C Radical SAM
CCEKOFMD_00118 3.6e-61 C Radical SAM
CCEKOFMD_00120 1.4e-59 Z012_04635 K sequence-specific DNA binding
CCEKOFMD_00121 3.2e-56 Z012_04635 K sequence-specific DNA binding
CCEKOFMD_00122 2.4e-13 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
CCEKOFMD_00123 3.7e-29 S Domain of unknown function (DUF4649)
CCEKOFMD_00124 6.9e-131 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
CCEKOFMD_00125 9e-59 XK27_04120 S Putative amino acid metabolism
CCEKOFMD_00126 1.2e-205 iscS 2.8.1.7 E Cysteine desulfurase
CCEKOFMD_00127 1.2e-177 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CCEKOFMD_00128 1.5e-103 yjbK S Adenylate cyclase
CCEKOFMD_00129 5.5e-121 yjbM 2.7.6.5 S Gtp pyrophosphokinase
CCEKOFMD_00130 5.4e-150 nadK 2.7.1.23 H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CCEKOFMD_00131 9.8e-174 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 J Responsible for synthesis of pseudouridine from uracil
CCEKOFMD_00132 1.4e-181 pta 2.3.1.8, 3.6.3.21 C phosphate acetyltransferase
CCEKOFMD_00133 8.9e-18 L transposase activity
CCEKOFMD_00134 1.1e-23 L transposase activity
CCEKOFMD_00135 1e-110 L Integrase core domain protein
CCEKOFMD_00136 6.7e-218 oxlT P COG0477 Permeases of the major facilitator superfamily
CCEKOFMD_00137 1.4e-40 tatD L Hydrolase, tatd
CCEKOFMD_00138 3.8e-45 oppF P Belongs to the ABC transporter superfamily
CCEKOFMD_00139 1.2e-24 oppF P Belongs to the ABC transporter superfamily
CCEKOFMD_00140 4.1e-158 L COG2801 Transposase and inactivated derivatives
CCEKOFMD_00141 8.1e-45 L Transposase
CCEKOFMD_00142 4.1e-237 amiA E ABC transporter, substrate-binding protein, family 5
CCEKOFMD_00143 2.1e-277 amiC P ABC transporter (Permease
CCEKOFMD_00144 4.9e-168 amiD P ABC transporter (Permease
CCEKOFMD_00145 2.2e-204 oppD P Belongs to the ABC transporter superfamily
CCEKOFMD_00146 4.3e-172 oppF P Belongs to the ABC transporter superfamily
CCEKOFMD_00147 3.3e-133 V ATPase activity
CCEKOFMD_00148 1.1e-119 skfE V abc transporter atp-binding protein
CCEKOFMD_00149 8.6e-63 yvoA_1 K Transcriptional
CCEKOFMD_00150 8.5e-145 supH S overlaps another CDS with the same product name
CCEKOFMD_00151 3.4e-149 XK27_02985 S overlaps another CDS with the same product name
CCEKOFMD_00152 2.8e-212 ftsY U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
CCEKOFMD_00153 9.8e-112 gmk 2.7.4.8 F Essential for recycling GMP and indirectly, cGMP
CCEKOFMD_00154 2.7e-46 rpoZ 2.7.7.6 K DNA-directed 5'-3' RNA polymerase activity
CCEKOFMD_00155 0.0 priA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CCEKOFMD_00156 3.5e-174 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CCEKOFMD_00157 4.4e-247 sun 2.1.1.176 J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CCEKOFMD_00158 2e-132 stp 3.1.3.16 T phosphatase
CCEKOFMD_00159 0.0 prkC 2.7.11.1 KLT serine threonine protein kinase
CCEKOFMD_00160 3.7e-120 yvqF KT membrane
CCEKOFMD_00161 5.8e-175 vraS 2.7.13.3 T Histidine kinase
CCEKOFMD_00162 2.2e-114 vraR K Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
CCEKOFMD_00165 5.8e-94 rimM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CCEKOFMD_00166 2.1e-134 trmD 2.1.1.228, 4.6.1.12 J Belongs to the RNA methyltransferase TrmD family
CCEKOFMD_00167 1.6e-188 trxB1 1.18.1.2, 1.19.1.1 C Ferredoxin--NADP reductase
CCEKOFMD_00168 0.0 ftsK D Belongs to the FtsK SpoIIIE SftA family
CCEKOFMD_00169 7e-119 pulA 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
CCEKOFMD_00170 1.8e-33 pulA 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
CCEKOFMD_00171 7e-150 pulA 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
CCEKOFMD_00172 6.4e-62 L Transposase
CCEKOFMD_00173 0.0 gshF 6.3.2.2, 6.3.2.29, 6.3.2.30, 6.3.2.4 H Belongs to the glutamate--cysteine ligase type 1 family
CCEKOFMD_00174 4.3e-40 V abc transporter atp-binding protein
CCEKOFMD_00175 2.5e-101 V abc transporter atp-binding protein
CCEKOFMD_00176 6.7e-17 rtxA M M26 IgA1-specific Metallo-endopeptidase C-terminal region
CCEKOFMD_00177 3.5e-228 zmpB M M26 IgA1-specific Metallo-endopeptidase C-terminal region
CCEKOFMD_00178 1.2e-25 L transposition
CCEKOFMD_00179 2.7e-08 L Integrase core domain protein
CCEKOFMD_00180 2.3e-184 galR K Transcriptional regulator
CCEKOFMD_00181 8.1e-221 galK 2.7.1.6 G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CCEKOFMD_00182 2.1e-293 galT 2.7.7.12 G UDPglucose--hexose-1-phosphate uridylyltransferase
CCEKOFMD_00183 6.6e-195 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
CCEKOFMD_00184 6.4e-201 galM 5.1.3.3 G Catalyzes the interconversion of alpha and beta anomers of maltose
CCEKOFMD_00185 0.0 lacS G transporter
CCEKOFMD_00186 0.0 lacL 3.2.1.23 G -beta-galactosidase
CCEKOFMD_00187 1.5e-230 sbcD L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
CCEKOFMD_00188 0.0 sbcC L ATPase involved in DNA repair
CCEKOFMD_00189 2.8e-85
CCEKOFMD_00191 1.8e-87 L transposase activity
CCEKOFMD_00192 1.4e-150 L Integrase core domain protein
CCEKOFMD_00193 6.5e-159 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
CCEKOFMD_00195 1.6e-257 I radical SAM domain protein
CCEKOFMD_00196 1.2e-176 EGP Major Facilitator Superfamily
CCEKOFMD_00197 3.9e-110 C Fe-S oxidoreductases
CCEKOFMD_00199 1.1e-151 V MatE
CCEKOFMD_00200 3.1e-116 devA 3.6.3.25 V abc transporter atp-binding protein
CCEKOFMD_00201 6.5e-161 hrtB V MacB-like periplasmic core domain
CCEKOFMD_00203 0.0 M family 8
CCEKOFMD_00204 2.7e-09
CCEKOFMD_00205 5.6e-08
CCEKOFMD_00206 5.8e-109 MA20_06410 E LysE type translocator
CCEKOFMD_00207 2.7e-12 IQ PFAM AMP-dependent synthetase and ligase
CCEKOFMD_00208 5.3e-12 IQ PFAM AMP-dependent synthetase and ligase
CCEKOFMD_00209 1e-137
CCEKOFMD_00210 1.8e-270 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CCEKOFMD_00211 4.5e-61
CCEKOFMD_00212 9.3e-72 S Signal peptide protein, YSIRK family
CCEKOFMD_00213 1.4e-54 K response regulator
CCEKOFMD_00214 1.1e-37 BP1961 P nitric oxide dioxygenase activity
CCEKOFMD_00216 3.6e-282 XK27_07020 S Belongs to the UPF0371 family
CCEKOFMD_00217 1.7e-179 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
CCEKOFMD_00218 6.8e-161 yvgN C reductase
CCEKOFMD_00220 3e-102 yoaK S Protein of unknown function (DUF1275)
CCEKOFMD_00221 1.4e-110 drgA C Nitroreductase
CCEKOFMD_00222 5.6e-231 pts13C G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
CCEKOFMD_00223 8.6e-159 E Alpha/beta hydrolase of unknown function (DUF915)
CCEKOFMD_00224 4.7e-76 ywnA K Transcriptional regulator
CCEKOFMD_00225 9.5e-150 1.13.11.2 S glyoxalase
CCEKOFMD_00226 5.1e-110 XK27_02070 S nitroreductase
CCEKOFMD_00228 2.1e-71 ydhF S Aldo keto reductase
CCEKOFMD_00229 1.1e-59 ydhF S Aldo keto reductase
CCEKOFMD_00230 3.9e-82 K WHG domain
CCEKOFMD_00231 3.2e-91 V abc transporter atp-binding protein
CCEKOFMD_00232 5.9e-23 P FtsX-like permease family
CCEKOFMD_00233 2.4e-40 S Sugar efflux transporter for intercellular exchange
CCEKOFMD_00234 1.1e-83 btuE 1.11.1.9 O Belongs to the glutathione peroxidase family
CCEKOFMD_00235 8.1e-161 4.1.1.37 H Uroporphyrinogen decarboxylase (URO-D)
CCEKOFMD_00236 1.8e-161 ET ABC transporter substrate-binding protein
CCEKOFMD_00237 6.1e-107 ytmL P ABC transporter (Permease
CCEKOFMD_00238 3e-114 yxeN P ABC transporter, permease protein
CCEKOFMD_00239 6.9e-136 tcyC2 3.6.3.21 E abc transporter atp-binding protein
CCEKOFMD_00242 1.6e-21 L Integrase core domain protein
CCEKOFMD_00243 1.1e-139 S dextransucrase activity
CCEKOFMD_00244 4.9e-228 S dextransucrase activity
CCEKOFMD_00245 6.2e-228 yfnA E amino acid
CCEKOFMD_00247 9.6e-26 csbD K CsbD-like
CCEKOFMD_00248 8.2e-57 manA 5.3.1.8 G mannose-6-phosphate isomerase
CCEKOFMD_00249 9.4e-65 manA 5.3.1.8 G mannose-6-phosphate isomerase
CCEKOFMD_00250 5.6e-234 brnQ E Component of the transport system for branched-chain amino acids
CCEKOFMD_00251 6.7e-129 hipO E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
CCEKOFMD_00252 6.7e-35 hipO E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
CCEKOFMD_00253 3.2e-07 gldA 1.1.1.1, 1.1.1.6 C glycerol dehydrogenase
CCEKOFMD_00254 1.5e-78 gldA 1.1.1.1, 1.1.1.6 C glycerol dehydrogenase
CCEKOFMD_00255 5.6e-145 ykrV3 2.6.1.83 E mutations do not affect methionine salvage in vivo however
CCEKOFMD_00256 3e-115 yxeQ S MmgE/PrpD family
CCEKOFMD_00257 4.1e-58 yxeL K Acetyltransferase (GNAT) domain
CCEKOFMD_00258 4.1e-63 yxeN U ABC transporter, permease protein
CCEKOFMD_00259 7.3e-93 yxeO 3.6.3.21 E abc transporter atp-binding protein
CCEKOFMD_00260 2.9e-198 pcaB 4.3.2.2 F Adenylosuccinate lyase
CCEKOFMD_00261 3.5e-85 yxeM ET Belongs to the bacterial solute-binding protein 3 family
CCEKOFMD_00262 6.3e-187 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CCEKOFMD_00263 3.4e-247 norM V Multidrug efflux pump
CCEKOFMD_00264 1.2e-198 pbuX F xanthine permease
CCEKOFMD_00266 3.2e-78 xpt 2.4.2.22, 2.4.2.7 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
CCEKOFMD_00267 4.6e-123 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
CCEKOFMD_00268 6.2e-166 T Histidine kinase
CCEKOFMD_00269 3.2e-133 macB2 V ABC transporter, ATP-binding protein
CCEKOFMD_00270 0.0 V ABC transporter (permease)
CCEKOFMD_00271 6.1e-93 XK27_05000 S metal cluster binding
CCEKOFMD_00272 2.6e-30 liaI KT membrane
CCEKOFMD_00273 1.4e-15 liaI KT membrane
CCEKOFMD_00274 6.1e-26 XK27_09825 V 'abc transporter, ATP-binding protein
CCEKOFMD_00275 3.7e-122 S An automated process has identified a potential problem with this gene model
CCEKOFMD_00277 4.6e-95 L Transposase
CCEKOFMD_00278 4.6e-42 3.6.1.55 F NUDIX domain
CCEKOFMD_00279 6e-152 mutR K Transcriptional activator, Rgg GadR MutR family
CCEKOFMD_00280 0.0 2.7.7.73, 2.7.7.80 E metalloendopeptidase activity
CCEKOFMD_00281 6.6e-213 EGP Major facilitator Superfamily
CCEKOFMD_00285 8.7e-159 XK27_09825 V abc transporter atp-binding protein
CCEKOFMD_00286 1.4e-133 yvfS V ABC-2 type transporter
CCEKOFMD_00287 1.5e-192 desK 2.7.13.3 T Histidine kinase
CCEKOFMD_00288 4.4e-101 desR K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
CCEKOFMD_00289 3.6e-97 S transport system, permease component
CCEKOFMD_00290 1.1e-144 S ABC-2 family transporter protein
CCEKOFMD_00291 7.4e-26
CCEKOFMD_00292 9.6e-150 sdaAA 4.3.1.17 E L-serine dehydratase
CCEKOFMD_00293 3.8e-122 sdaAB 4.3.1.17 E L-serine dehydratase
CCEKOFMD_00294 5.1e-130 yjjG 3.1.3.102, 3.1.3.104, 3.1.3.5, 3.8.1.2 E hydrolase
CCEKOFMD_00295 0.0 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
CCEKOFMD_00296 4e-278 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CCEKOFMD_00297 6.3e-23
CCEKOFMD_00298 3e-13
CCEKOFMD_00299 2.4e-92 pat 2.3.1.183 M acetyltransferase
CCEKOFMD_00300 1.1e-198 asd 1.2.1.11 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CCEKOFMD_00301 6.6e-173 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CCEKOFMD_00302 8.4e-125 rnc 3.1.26.3 J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
CCEKOFMD_00303 0.0 smc D Required for chromosome condensation and partitioning
CCEKOFMD_00304 9.6e-197 pheS 6.1.1.20 J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CCEKOFMD_00305 9.9e-94 paiA 2.3.1.57 K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
CCEKOFMD_00306 0.0 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
CCEKOFMD_00308 2e-55 nrdD_1 1.1.98.6, 1.17.4.1 F Ribonucleoside-triphosphate reductase
CCEKOFMD_00309 7.7e-241 XK27_08130 K Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
CCEKOFMD_00311 7.4e-86 S ECF-type riboflavin transporter, S component
CCEKOFMD_00312 4.5e-44 pdxK 2.7.1.35 H Belongs to the pyridoxine kinase family
CCEKOFMD_00313 8.7e-85 pdxK 2.7.1.35 H Belongs to the pyridoxine kinase family
CCEKOFMD_00314 3.3e-82 XK27_01265 S ECF-type riboflavin transporter, S component
CCEKOFMD_00315 1.9e-294 yfmM S abc transporter atp-binding protein
CCEKOFMD_00316 3.4e-258 noxE P NADH oxidase
CCEKOFMD_00317 1.1e-181 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
CCEKOFMD_00318 0.0 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CCEKOFMD_00319 1.7e-134 srtA 3.4.22.70 M Sortase (surface protein transpeptidase)
CCEKOFMD_00320 1.4e-71 yaeR E COG0346 Lactoylglutathione lyase and related lyases
CCEKOFMD_00321 9e-165 ypuA S secreted protein
CCEKOFMD_00322 8.8e-60 L Transposase (IS116 IS110 IS902 family)
CCEKOFMD_00323 3.6e-70 L Transposase (IS116 IS110 IS902 family)
CCEKOFMD_00325 1.7e-184 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CCEKOFMD_00326 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CCEKOFMD_00327 7.2e-33 nrdH O Glutaredoxin
CCEKOFMD_00328 0.0 acnA 4.2.1.3 C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CCEKOFMD_00329 4.3e-211 citZ 2.3.3.1 C Belongs to the citrate synthase family
CCEKOFMD_00330 9.7e-222 icd 1.1.1.42 C Isocitrate dehydrogenase
CCEKOFMD_00331 7.9e-39 ptsH G phosphocarrier protein Hpr
CCEKOFMD_00332 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CCEKOFMD_00333 5.6e-264 gapN 1.2.1.9 C Belongs to the aldehyde dehydrogenase family
CCEKOFMD_00334 9.6e-29 6.3.2.2, 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
CCEKOFMD_00335 2.5e-176 yfmL 3.6.4.13 L DEAD DEAH box helicase
CCEKOFMD_00336 2.1e-114 udk 2.7.1.48 F Cytidine monophosphokinase
CCEKOFMD_00337 0.0 uup S abc transporter atp-binding protein
CCEKOFMD_00338 2.2e-131 pip 1.11.1.10 S Alpha beta hydrolase
CCEKOFMD_00339 0.0 mprF 2.3.2.3 J Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CCEKOFMD_00340 8.7e-150 cobQ S glutamine amidotransferase
CCEKOFMD_00341 7.5e-255 murD 3.4.21.10, 6.3.2.13, 6.3.2.9 M Mur ligase, middle domain protein
CCEKOFMD_00342 5.6e-124 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CCEKOFMD_00343 6e-169 ybbR S Protein conserved in bacteria
CCEKOFMD_00344 1.6e-249 glmM 5.4.2.10 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CCEKOFMD_00345 1.7e-70 gtrA S GtrA-like protein
CCEKOFMD_00346 8.7e-122 trmK 2.1.1.217 S SAM-dependent methyltransferase
CCEKOFMD_00347 9.6e-149 yqfO 3.5.4.16 S Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CCEKOFMD_00348 5.7e-102 zupT P Mediates zinc uptake. May also transport other divalent cations
CCEKOFMD_00349 1.1e-206 yurR 1.4.5.1 E oxidoreductase
CCEKOFMD_00350 2.4e-161 rfbA 2.7.7.24 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CCEKOFMD_00351 2.1e-111 rmlC 1.1.1.133, 5.1.3.13 M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
CCEKOFMD_00352 1.9e-205 rfbB 4.2.1.46 M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
CCEKOFMD_00355 4.1e-217 hemN H Involved in the biosynthesis of porphyrin-containing compound
CCEKOFMD_00356 6.7e-144 fat 3.1.2.21 I Acyl-ACP thioesterase
CCEKOFMD_00357 5.9e-143 nagD 2.7.1.25, 3.1.3.41 G Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
CCEKOFMD_00358 5.3e-121 ylfI S tigr01906
CCEKOFMD_00359 2e-140 hisK 3.1.3.15 E Histidinol phosphatase and related hydrolases of the PHP family
CCEKOFMD_00360 2.3e-09 XK27_08080 3.1.1.53 G Exopolysaccharide biosynthesis protein
CCEKOFMD_00361 5.6e-92 XK27_08080 3.1.1.53 G Exopolysaccharide biosynthesis protein
CCEKOFMD_00362 1.3e-22 XK27_08085
CCEKOFMD_00363 5.2e-36 L transposase activity
CCEKOFMD_00365 2.1e-196 hisC 2.6.1.9 E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CCEKOFMD_00366 5.7e-183 hisZ 2.4.2.17, 6.1.1.21 E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CCEKOFMD_00367 2.3e-116 hisG 2.4.2.17 E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
CCEKOFMD_00368 1.1e-234 hisD 1.1.1.23, 1.1.1.308 E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CCEKOFMD_00369 1.5e-106 hisB 1.1.1.23, 2.6.1.9, 3.1.3.15, 4.2.1.19 E imidazoleglycerol-phosphate dehydratase
CCEKOFMD_00370 1.2e-109 hisH E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CCEKOFMD_00371 5e-128 hisA 5.3.1.16 E 1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CCEKOFMD_00372 1.9e-133 hisF 3.5.4.19, 3.6.1.31 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
CCEKOFMD_00373 5.5e-61 hisI 3.5.4.19, 3.5.4.25, 3.6.1.31, 5.3.1.16 E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CCEKOFMD_00374 4.5e-49 hisE 3.5.4.19, 3.6.1.31, 5.3.1.16 E phosphoribosyl-ATP diphosphatase activity
CCEKOFMD_00375 1.6e-239 rodA D Belongs to the SEDS family
CCEKOFMD_00376 7.1e-223 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CCEKOFMD_00377 1e-116 galT 2.7.7.12 G UDPglucose--hexose-1-phosphate uridylyltransferase
CCEKOFMD_00378 2e-174 rnz 3.1.26.11 S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
CCEKOFMD_00379 6.7e-139 XK27_05435 1.1.1.100 S Belongs to the short-chain dehydrogenases reductases (SDR) family
CCEKOFMD_00380 0.0 recJ L Single-strand DNA-specific exonuclease, C terminal domain
CCEKOFMD_00381 2e-94 apt 2.4.2.22, 2.4.2.7 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CCEKOFMD_00382 6e-182 metA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CCEKOFMD_00383 2.9e-125 dnaD
CCEKOFMD_00384 3.4e-120 nth 4.2.99.18 L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CCEKOFMD_00387 1.2e-247 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
CCEKOFMD_00388 3.5e-29 xseB 3.1.11.6 L exodeoxyribonuclease VII activity
CCEKOFMD_00389 3e-159 ispA 2.5.1.1, 2.5.1.10, 2.5.1.29, 2.5.1.90 H Belongs to the FPP GGPP synthase family
CCEKOFMD_00390 5e-159 rrmJ 2.1.1.226, 2.1.1.227 J Ribosomal RNA large subunit methyltransferase J
CCEKOFMD_00391 1.8e-72 argR K Regulates arginine biosynthesis genes
CCEKOFMD_00392 5.8e-305 recN L May be involved in recombinational repair of damaged DNA
CCEKOFMD_00393 1e-148 DegV S DegV family
CCEKOFMD_00394 3.9e-143 ypmR E lipolytic protein G-D-S-L family
CCEKOFMD_00395 1.7e-83 ypmS S Protein conserved in bacteria
CCEKOFMD_00396 2.8e-39 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
CCEKOFMD_00398 3.6e-179 pyrD 1.3.1.14, 1.3.98.1 F Catalyzes the conversion of dihydroorotate to orotate
CCEKOFMD_00399 4.6e-131 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CCEKOFMD_00400 3.4e-291 leuA 2.3.3.13 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CCEKOFMD_00401 6.6e-190 leuB 1.1.1.85 CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
CCEKOFMD_00402 2.5e-43 ysdA L Membrane
CCEKOFMD_00403 6.8e-275 leuC 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CCEKOFMD_00404 3.1e-112 leuD 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CCEKOFMD_00405 1.4e-152 sua5 2.7.7.87 J Belongs to the SUA5 family
CCEKOFMD_00406 0.0 dnaE 2.7.7.7 L DNA polymerase
CCEKOFMD_00407 1.2e-188 pfkA 2.7.1.11 F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
CCEKOFMD_00408 1.3e-276 pyk 2.7.1.40, 2.7.7.4 G Belongs to the pyruvate kinase family
CCEKOFMD_00409 3.2e-09 Q the current gene model (or a revised gene model) may contain a frame shift
CCEKOFMD_00410 3e-25 Q the current gene model (or a revised gene model) may contain a frame shift
CCEKOFMD_00411 8.1e-42 Q the current gene model (or a revised gene model) may contain a frame shift
CCEKOFMD_00413 3.3e-178 XK27_08835 S ABC transporter substrate binding protein
CCEKOFMD_00414 5.2e-148 XK27_08840 S Belongs to the binding-protein-dependent transport system permease family
CCEKOFMD_00415 4.4e-135 XK27_08845 S abc transporter atp-binding protein
CCEKOFMD_00416 3e-309 rnjB S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CCEKOFMD_00417 1.6e-151 estA CE1 S Putative esterase
CCEKOFMD_00418 6.1e-126 XK27_08875 O Zinc-dependent metalloprotease
CCEKOFMD_00419 5.5e-14 XK27_08880
CCEKOFMD_00420 2.3e-75 fld C Flavodoxin
CCEKOFMD_00421 1.3e-282 clcA P Chloride transporter, ClC family
CCEKOFMD_00422 8.7e-41 pheA 1.3.1.12, 2.3.1.79, 4.2.1.51, 5.4.99.5 E Chorismate mutase
CCEKOFMD_00423 2.1e-219 XK27_05110 P chloride
CCEKOFMD_00424 8.5e-57 rplS J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
CCEKOFMD_00427 2.1e-19 WQ51_02665 S Protein of unknown function (DUF3042)
CCEKOFMD_00428 4.9e-165 miaA 2.5.1.75 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CCEKOFMD_00429 1.6e-88 ytsP 1.8.4.14 T GAF domain-containing protein
CCEKOFMD_00430 3.2e-295 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CCEKOFMD_00431 4.2e-175 birA 6.3.4.15 HK Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
CCEKOFMD_00432 2.1e-203 metK 2.5.1.6 H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CCEKOFMD_00433 1.3e-25 G Domain of unknown function (DUF4832)
CCEKOFMD_00434 2.7e-196 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
CCEKOFMD_00436 7.2e-231 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CCEKOFMD_00437 1.2e-25 epuA S DNA-directed RNA polymerase subunit beta
CCEKOFMD_00438 2.4e-124 endA F DNA RNA non-specific endonuclease
CCEKOFMD_00439 1.7e-111 tcyB_2 P ABC transporter (permease)
CCEKOFMD_00440 5.9e-118 gltJ P ABC transporter (Permease
CCEKOFMD_00441 3.1e-150 peb1A ET ABC-type amino acid transport signal transduction systems, periplasmic component domain
CCEKOFMD_00442 2.1e-140 glnQ 3.6.3.21 E abc transporter atp-binding protein
CCEKOFMD_00443 9.9e-129 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
CCEKOFMD_00444 1.5e-247 vicK 2.7.13.3 T Histidine kinase
CCEKOFMD_00445 2.1e-154 vicX 3.1.26.11 S Metal-dependent hydrolases of the beta-lactamase superfamily I
CCEKOFMD_00446 9e-231 murM 2.3.2.10, 2.3.2.16 V protein involved in methicillin resistance
CCEKOFMD_00447 9.2e-147 yidA S hydrolases of the HAD superfamily
CCEKOFMD_00448 6.3e-51 XK27_00115 2.3.1.128 K acetyltransferase
CCEKOFMD_00449 2.6e-67 ywiB S Domain of unknown function (DUF1934)
CCEKOFMD_00450 0.0 pacL 3.6.3.8 P cation transport ATPase
CCEKOFMD_00451 5.2e-136 nfrA 1.5.1.38, 1.5.1.39 C nitroreductase
CCEKOFMD_00452 4.3e-180 yjjH S Calcineurin-like phosphoesterase
CCEKOFMD_00453 2.7e-202 queG 1.17.99.6 C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CCEKOFMD_00454 1.6e-182 prfB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CCEKOFMD_00455 2.5e-124 ftsE D cell division ATP-binding protein FtsE
CCEKOFMD_00456 3.6e-163 ftsX D Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation
CCEKOFMD_00457 3.5e-93 mutX 3.6.1.55 F NTP pyrophosphohydrolases including oxidative damage repair enzymes
CCEKOFMD_00458 4e-175 yubA S permease
CCEKOFMD_00459 8.3e-224 G COG0457 FOG TPR repeat
CCEKOFMD_00460 4.2e-98 lepB 3.4.21.89 U Belongs to the peptidase S26 family
CCEKOFMD_00461 1.8e-234 pepT 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
CCEKOFMD_00462 2.9e-90 ebsA S Family of unknown function (DUF5322)
CCEKOFMD_00463 1.4e-22 M LysM domain
CCEKOFMD_00464 2.5e-121 cmk 1.17.7.4, 2.5.1.19, 2.7.1.26, 2.7.4.25, 2.7.7.2, 6.3.2.1 F Belongs to the cytidylate kinase family. Type 1 subfamily
CCEKOFMD_00465 3.5e-86 infC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CCEKOFMD_00466 2.1e-28 rpmI J Belongs to the bacterial ribosomal protein bL35 family
CCEKOFMD_00467 1.5e-56 rplT J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CCEKOFMD_00468 7.2e-83 L Transposase
CCEKOFMD_00469 2e-41 XK27_03610 K Gnat family
CCEKOFMD_00470 6.4e-27 dmpI 5.3.2.6 G Belongs to the 4-oxalocrotonate tautomerase family
CCEKOFMD_00471 2.4e-275 pepV 3.5.1.18 E Dipeptidase
CCEKOFMD_00472 1e-110 ung2 3.2.2.27 L Uracil-DNA glycosylase
CCEKOFMD_00473 4e-21 V Glucan-binding protein C
CCEKOFMD_00475 1.7e-122 rpiA 2.7.1.12, 2.7.1.15, 5.3.1.6 G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CCEKOFMD_00476 2.9e-237 deoB 5.4.2.7 G Phosphotransfer between the C1 and C5 carbon atoms of pentose
CCEKOFMD_00477 2.3e-66 S Protein of unknown function (DUF1697)
CCEKOFMD_00478 4.4e-149 punA 2.4.2.1 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CCEKOFMD_00479 4.9e-80 clcA_2 P chloride
CCEKOFMD_00480 6.3e-13 yfeJ 6.3.5.2 F glutamine amidotransferase
CCEKOFMD_00481 9.8e-96 yfeJ 6.3.5.2 F glutamine amidotransferase
CCEKOFMD_00482 3.4e-129 deoD 2.4.2.1, 2.4.2.28 F purine nucleoside phosphorylase
CCEKOFMD_00483 5.9e-253 cps4A K Cell envelope-like function transcriptional attenuator common domain protein
CCEKOFMD_00484 2.8e-134 cpsB 3.1.3.48 GM Capsular polysaccharide biosynthesis protein
CCEKOFMD_00485 4.4e-105 cps4C M biosynthesis protein
CCEKOFMD_00486 2.8e-113 cpsD D COG0489 ATPases involved in chromosome partitioning
CCEKOFMD_00487 1.7e-249 cpsE M Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
CCEKOFMD_00488 9.7e-23 rgpAc GT4 M group 1 family protein
CCEKOFMD_00489 5.8e-28 tnp L DDE domain
CCEKOFMD_00490 2.2e-22 L Transposase
CCEKOFMD_00491 4.7e-140 L Integrase core domain
CCEKOFMD_00492 6.9e-96 2.7.8.12 GT2 S Glycosyltransferase like family 2
CCEKOFMD_00493 1.3e-23 L Transposase
CCEKOFMD_00494 6.4e-236 cps1C S Polysaccharide biosynthesis protein
CCEKOFMD_00495 4.1e-59 L COG2801 Transposase and inactivated derivatives
CCEKOFMD_00496 1.2e-70 rfbP 2.7.8.6 M Bacterial sugar transferase
CCEKOFMD_00497 7e-66 cpsF M Oligosaccharide biosynthesis protein Alg14 like
CCEKOFMD_00498 1.5e-41 pssE S Glycosyltransferase family 28 C-terminal domain
CCEKOFMD_00499 6.5e-72 M Glycosyltransferase sugar-binding region containing DXD motif
CCEKOFMD_00500 1.6e-16
CCEKOFMD_00501 3.2e-32 cpsJ S Glycosyltransferase like family 2
CCEKOFMD_00502 4.9e-94 V VanZ like family
CCEKOFMD_00503 1.1e-15 supH 3.1.3.102, 3.1.3.104 S Sucrose-6F-phosphate phosphohydrolase
CCEKOFMD_00504 2.4e-68 supH 3.1.3.102, 3.1.3.104 Q phosphatase activity
CCEKOFMD_00505 5.6e-101 G Belongs to the phosphoglycerate mutase family
CCEKOFMD_00506 1.3e-199 S hmm pf01594
CCEKOFMD_00507 1.8e-98 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
CCEKOFMD_00508 3.8e-43 bglH 3.2.1.86 GT1 G beta-glucosidase activity
CCEKOFMD_00509 7.1e-36 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
CCEKOFMD_00510 4.9e-39 S granule-associated protein
CCEKOFMD_00511 7.7e-291 S unusual protein kinase
CCEKOFMD_00512 2.6e-15 estA E Lysophospholipase L1 and related esterases
CCEKOFMD_00513 3.9e-78 estA E GDSL-like protein
CCEKOFMD_00514 1.2e-157 rssA S Phospholipase, patatin family
CCEKOFMD_00515 1.1e-215 yeaB K Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CCEKOFMD_00516 7.7e-128 ung 3.2.2.27 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CCEKOFMD_00517 1.1e-234 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
CCEKOFMD_00518 4.4e-66 S the current gene model (or a revised gene model) may contain a frame shift
CCEKOFMD_00519 6e-185 acoA 1.2.4.1, 1.2.4.4 C Dehydrogenase E1 component
CCEKOFMD_00520 3.7e-182 acoB 1.2.4.1, 1.2.4.4 C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
CCEKOFMD_00521 1.8e-198 acoC 2.3.1.12 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
CCEKOFMD_00522 0.0 lpdA 1.8.1.4 C Dehydrogenase
CCEKOFMD_00523 2.6e-20 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
CCEKOFMD_00524 3.6e-82 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
CCEKOFMD_00525 8.5e-266 3.5.1.28 NU amidase activity
CCEKOFMD_00526 1.9e-37 3.5.1.28 NU amidase activity
CCEKOFMD_00527 2.4e-134 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
CCEKOFMD_00528 3.9e-65 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
CCEKOFMD_00529 1.1e-53 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
CCEKOFMD_00530 2e-139 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
CCEKOFMD_00531 4e-165 yclN P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CCEKOFMD_00532 2.5e-167 fatC P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CCEKOFMD_00533 6.8e-136 yclP 3.6.3.34 P abc transporter atp-binding protein
CCEKOFMD_00534 2.2e-177 fatB P ABC-type enterochelin transport system, periplasmic component
CCEKOFMD_00535 2.1e-152 ycdO P periplasmic lipoprotein involved in iron transport
CCEKOFMD_00536 1.5e-233 ycdB P peroxidase
CCEKOFMD_00537 3e-301 ywbL P COG0672 High-affinity Fe2 Pb2 permease
CCEKOFMD_00538 1.7e-120 tatC U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CCEKOFMD_00539 4.6e-25 tatA U protein secretion
CCEKOFMD_00540 2.4e-111 malF P ABC transporter (Permease
CCEKOFMD_00541 1.9e-93 malX G ABC transporter
CCEKOFMD_00542 4.2e-17 malX G ABC transporter
CCEKOFMD_00543 4.2e-27 malR K Transcriptional regulator
CCEKOFMD_00544 2.4e-63 malR K Transcriptional regulator
CCEKOFMD_00545 1.9e-302 malQ 2.4.1.25 GH77 G 4-alpha-glucanotransferase
CCEKOFMD_00546 0.0 glgP 2.4.1.1 GT35 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
CCEKOFMD_00547 3.7e-09
CCEKOFMD_00548 1.1e-17
CCEKOFMD_00549 1.3e-187 lplA 6.3.1.20 H Lipoate-protein ligase
CCEKOFMD_00550 7e-195 xerS D Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division
CCEKOFMD_00551 0.0 pepN 3.4.11.2 E aminopeptidase
CCEKOFMD_00552 2.4e-113 phoU P Plays a role in the regulation of phosphate uptake
CCEKOFMD_00553 1.7e-139 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
CCEKOFMD_00554 5.2e-150 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
CCEKOFMD_00555 1.2e-155 pstA P phosphate transport system permease
CCEKOFMD_00556 1.8e-154 pstC P probably responsible for the translocation of the substrate across the membrane
CCEKOFMD_00557 3.3e-158 pstS P phosphate
CCEKOFMD_00558 3e-256 rsmF 2.1.1.176, 2.1.1.178 J NOL1 NOP2 sun family protein
CCEKOFMD_00559 5e-142 suhB 3.1.3.25 G Belongs to the inositol monophosphatase superfamily
CCEKOFMD_00560 1.9e-43 yktA S Belongs to the UPF0223 family
CCEKOFMD_00561 6.1e-70 spxA 1.20.4.1 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
CCEKOFMD_00562 1.3e-173 ribF 2.7.1.26, 2.7.7.2 H Belongs to the ribF family
CCEKOFMD_00563 2.4e-150 truB 5.4.99.25 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CCEKOFMD_00564 3.6e-136 XK27_04775 S hemerythrin HHE cation binding domain
CCEKOFMD_00565 1.1e-110 hsdS2 2.1.1.72 V Type I restriction modification DNA specificity domain
CCEKOFMD_00566 3.5e-88 tpx 1.11.1.15 O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CCEKOFMD_00567 9.3e-62 S haloacid dehalogenase-like hydrolase
CCEKOFMD_00568 1.8e-59 Q phosphatase activity
CCEKOFMD_00569 3.5e-241 metY 2.5.1.49 E o-acetylhomoserine
CCEKOFMD_00570 0.0 pcrA 3.6.4.12 L ATP-dependent DNA helicase
CCEKOFMD_00571 1.8e-240 agcS E (Alanine) symporter
CCEKOFMD_00572 1.6e-247 mnmE S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CCEKOFMD_00573 7.6e-64 yfiF3 K sequence-specific DNA binding
CCEKOFMD_00574 3.7e-60 sasH 3.1.3.5, 3.6.1.45 F Belongs to the 5'-nucleotidase family
CCEKOFMD_00575 8.1e-114 sasH 3.1.3.5, 3.6.1.45 F Belongs to the 5'-nucleotidase family
CCEKOFMD_00577 3.5e-68 yecS P ABC transporter (Permease
CCEKOFMD_00578 8.2e-132 yckB ET Belongs to the bacterial solute-binding protein 3 family
CCEKOFMD_00579 1e-103 nylA 3.5.1.4 J Belongs to the amidase family
CCEKOFMD_00580 9.3e-267 dtpT E transporter
CCEKOFMD_00581 7.5e-112 pyrE 2.4.2.10, 4.1.1.23 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CCEKOFMD_00582 2e-126 pyrF 4.1.1.23 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
CCEKOFMD_00583 5.2e-74 csm6 S Psort location Cytoplasmic, score
CCEKOFMD_00584 2.1e-14 csm6 S Psort location Cytoplasmic, score
CCEKOFMD_00585 1e-193 csm5 L CRISPR-associated RAMP protein, Csm5 family
CCEKOFMD_00586 1.4e-164 csm4 L CRISPR-associated RAMP protein, Csm4 family
CCEKOFMD_00587 1.1e-116 csm3 L RAMP superfamily
CCEKOFMD_00588 5.6e-62 csm2 L Pfam:DUF310
CCEKOFMD_00589 0.0 csm1 S CRISPR-associated protein Csm1 family
CCEKOFMD_00590 1.3e-131 cas6 S CRISPR-associated endoribonuclease Cas6
CCEKOFMD_00591 3.7e-54 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CCEKOFMD_00592 1.8e-184 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CCEKOFMD_00593 3.2e-175 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
CCEKOFMD_00594 2.4e-147 pyrK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )
CCEKOFMD_00595 3.2e-95 thiJ 2.7.11.1, 3.5.1.124 S DJ-1 family
CCEKOFMD_00596 2.1e-98 S TraX protein
CCEKOFMD_00597 6.4e-24 L Transposase
CCEKOFMD_00599 1.1e-12
CCEKOFMD_00600 4.1e-250 purA 6.3.4.4 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CCEKOFMD_00601 1e-80 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CCEKOFMD_00602 1.7e-35 XK27_09805 S MORN repeat protein
CCEKOFMD_00603 0.0 XK27_09800 I Acyltransferase
CCEKOFMD_00604 7.8e-188 ruvB 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
CCEKOFMD_00605 1.3e-48 rpsJ J Involved in the binding of tRNA to the ribosomes
CCEKOFMD_00606 1.1e-110 rplC J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CCEKOFMD_00607 5.7e-104 rplD J Forms part of the polypeptide exit tunnel
CCEKOFMD_00608 2.4e-44 rplW J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
CCEKOFMD_00609 8.8e-153 rplB J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CCEKOFMD_00610 4.9e-47 rpsS J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CCEKOFMD_00611 7.3e-53 rplV J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CCEKOFMD_00612 2.1e-117 rpsC J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CCEKOFMD_00613 7.2e-71 rplP J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CCEKOFMD_00614 2.7e-26 rpmC J Belongs to the universal ribosomal protein uL29 family
CCEKOFMD_00615 6e-39 rpsQ J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CCEKOFMD_00616 1.1e-59 rplN J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CCEKOFMD_00617 1.4e-47 rplX J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CCEKOFMD_00618 1.6e-94 rplE J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CCEKOFMD_00619 1.5e-28 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CCEKOFMD_00620 1.2e-67 rpsH J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CCEKOFMD_00621 2.3e-93 rplF J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CCEKOFMD_00622 1.9e-56 rplR J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CCEKOFMD_00623 1.7e-79 rpsE J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CCEKOFMD_00624 2.5e-23 rpmD J ribosomal protein l30
CCEKOFMD_00625 4.4e-58 rplO J binds to the 23S rRNA
CCEKOFMD_00626 1.4e-229 secY U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
CCEKOFMD_00627 9.2e-121 adk 2.7.4.3 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
CCEKOFMD_00628 2.7e-32 infA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CCEKOFMD_00629 6e-15 rpmJ J Belongs to the bacterial ribosomal protein bL36 family
CCEKOFMD_00630 4e-57 rpsM J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CCEKOFMD_00631 9.6e-62 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CCEKOFMD_00632 1.1e-170 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CCEKOFMD_00633 3.3e-62 rplQ J ribosomal protein l17
CCEKOFMD_00634 3.3e-113 L PFAM Integrase, catalytic core
CCEKOFMD_00635 3.3e-09 L PFAM Integrase, catalytic core
CCEKOFMD_00636 3.2e-12 6.3.2.2 H gamma-glutamylcysteine synthetase
CCEKOFMD_00637 8.1e-64 6.3.2.2 H gamma-glutamylcysteine synthetase
CCEKOFMD_00638 6.7e-110 6.3.2.2 H ergothioneine biosynthetic process
CCEKOFMD_00640 9e-164 fba 4.1.2.13, 4.1.2.29 G aldolase
CCEKOFMD_00641 2.2e-282 dcm 2.1.1.37 H C-5 cytosine-specific DNA methylase
CCEKOFMD_00643 5.7e-217 S MvaI/BcnI restriction endonuclease family
CCEKOFMD_00645 7.7e-13
CCEKOFMD_00646 5e-31 S Hypothetical protein (DUF2513)
CCEKOFMD_00647 6.5e-31
CCEKOFMD_00648 1e-39
CCEKOFMD_00653 6.4e-136 HJ the current gene model (or a revised gene model) may contain a frame shift
CCEKOFMD_00654 1.2e-126 gltT C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
CCEKOFMD_00655 2.5e-13 2.3.1.82 M Acetyltransferase GNAT Family
CCEKOFMD_00656 2.5e-29 K Putative DNA-binding domain
CCEKOFMD_00657 3.3e-113 L PFAM Integrase, catalytic core
CCEKOFMD_00658 3.3e-09 L PFAM Integrase, catalytic core
CCEKOFMD_00661 3.3e-95 ywlG S Belongs to the UPF0340 family
CCEKOFMD_00662 1.2e-85 treR K trehalose operon
CCEKOFMD_00663 5.8e-21 treR K DNA-binding transcription factor activity
CCEKOFMD_00664 1.4e-54 treB 2.7.1.201 G PTS System
CCEKOFMD_00665 2.3e-65 treC 3.2.1.93 GH13 G COG0366 Glycosidases
CCEKOFMD_00666 1.2e-69 treC 3.2.1.93 GH13 G COG0366 Glycosidases
CCEKOFMD_00667 1.8e-37 treC 3.2.1.93 GH13 G COG0366 Glycosidases
CCEKOFMD_00668 0.0 pepO 3.4.24.71 O Peptidase family M13
CCEKOFMD_00669 1.4e-63 adhE 1.1.1.1, 1.2.1.10 C Dehydrogenase
CCEKOFMD_00670 1.3e-135 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
CCEKOFMD_00671 3.5e-76 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
CCEKOFMD_00672 1.2e-35 adhE 1.1.1.1, 1.2.1.10 C hydroxyacid-oxoacid transhydrogenase activity
CCEKOFMD_00673 3.2e-65 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
CCEKOFMD_00674 8.3e-279 thrC 4.2.3.1 E Threonine synthase
CCEKOFMD_00675 9.3e-226 norN V Mate efflux family protein
CCEKOFMD_00676 1.4e-57 asp S cog cog1302
CCEKOFMD_00677 6.4e-304 yloV S kinase related to dihydroxyacetone kinase
CCEKOFMD_00678 8.4e-09 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
CCEKOFMD_00679 2.6e-277 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
CCEKOFMD_00680 3.1e-08 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
CCEKOFMD_00681 0.0 ilvB 2.2.1.6 EH Acetolactate synthase
CCEKOFMD_00682 7.7e-77 ilvN 2.2.1.6 E Acetolactate synthase
CCEKOFMD_00683 1.6e-196 ilvC 1.1.1.86 H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CCEKOFMD_00684 1.2e-238 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CCEKOFMD_00685 0.0 pbp1B 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
CCEKOFMD_00686 0.0 rpoB 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CCEKOFMD_00687 0.0 rpoC 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CCEKOFMD_00688 2.9e-68 S cog cog4699
CCEKOFMD_00689 1.9e-175 comGA NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CCEKOFMD_00690 9.2e-153 cglB NU type II secretion system
CCEKOFMD_00691 8.5e-43 comGC U Required for transformation and DNA binding
CCEKOFMD_00692 1.8e-57 cglD NU Competence protein
CCEKOFMD_00693 1.4e-15 NU Type II secretory pathway pseudopilin
CCEKOFMD_00694 4e-72 comGF U Competence protein ComGF
CCEKOFMD_00695 6.8e-13 comGF U Putative Competence protein ComGF
CCEKOFMD_00696 5.9e-177 ytxK 2.1.1.72 L DNA methylase
CCEKOFMD_00697 2.9e-221 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CCEKOFMD_00698 8.8e-27 lanR K sequence-specific DNA binding
CCEKOFMD_00699 1.4e-33 V CAAX protease self-immunity
CCEKOFMD_00700 5e-67 V CAAX protease self-immunity
CCEKOFMD_00702 1.8e-111 S CAAX amino terminal protease family protein
CCEKOFMD_00703 3.9e-131 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CCEKOFMD_00704 2e-205 pepA 3.4.11.7 G COG1363 Cellulase M and related proteins
CCEKOFMD_00705 4.1e-09 S Domain of unknown function (DUF4651)
CCEKOFMD_00706 4.2e-55 ytpP 2.7.1.180, 5.3.4.1 CO Thioredoxin
CCEKOFMD_00707 7.9e-114 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
CCEKOFMD_00708 1.8e-187 yeeE S Sulphur transport
CCEKOFMD_00709 6.4e-37 yeeD O sulfur carrier activity
CCEKOFMD_00710 5.1e-66 ssb_2 L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
CCEKOFMD_00711 2.7e-91 tadA 3.5.4.1, 3.5.4.33 FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
CCEKOFMD_00714 1.3e-156 rrmA 2.1.1.187 Q methyltransferase
CCEKOFMD_00715 3.4e-64 S phosphatase activity
CCEKOFMD_00716 2.7e-48 S glycolate biosynthetic process
CCEKOFMD_00717 8.1e-59 dapD 2.3.1.117, 2.3.1.89 E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
CCEKOFMD_00718 1.8e-220 hipO 3.5.1.47 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
CCEKOFMD_00719 9.1e-95 ygfA 6.3.3.2 H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CCEKOFMD_00720 5.2e-119 gluP 3.4.21.105 O membrane protein (homolog of Drosophila rhomboid)
CCEKOFMD_00721 1.4e-189
CCEKOFMD_00722 6e-310 FbpA K RNA-binding protein homologous to eukaryotic snRNP
CCEKOFMD_00724 6.3e-12 dinF V Mate efflux family protein
CCEKOFMD_00725 8.8e-55 dinF V Mate efflux family protein
CCEKOFMD_00726 1.2e-18 yclQ P ABC-type enterochelin transport system, periplasmic component
CCEKOFMD_00727 3.6e-14 yclQ P ABC-type enterochelin transport system, periplasmic component
CCEKOFMD_00728 4.1e-118 gph 3.1.3.18 S HAD hydrolase, family IA, variant 1
CCEKOFMD_00729 2.6e-143 2.4.2.3 F Phosphorylase superfamily
CCEKOFMD_00732 3.8e-78 S Alpha/beta hydrolase of unknown function (DUF915)
CCEKOFMD_00733 7.9e-17 S Alpha/beta hydrolase of unknown function (DUF915)
CCEKOFMD_00734 6e-08 S Hydrolases of the alpha beta superfamily
CCEKOFMD_00735 6.2e-196 adhB 1.1.1.1, 1.1.1.14 E Dehydrogenase
CCEKOFMD_00736 2.7e-210 hemH 4.99.1.1, 4.99.1.9 H Catalyzes the ferrous insertion into protoporphyrin IX
CCEKOFMD_00737 1.8e-159 czcD P cation diffusion facilitator family transporter
CCEKOFMD_00738 9e-98 K Transcriptional regulator, TetR family
CCEKOFMD_00739 1.6e-10
CCEKOFMD_00740 2.8e-115 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
CCEKOFMD_00741 3e-14 V ABC transporter (Permease
CCEKOFMD_00742 4.1e-88 V ABC transporter (Permease
CCEKOFMD_00743 3e-133 budA 4.1.1.5 H Belongs to the alpha-acetolactate decarboxylase family
CCEKOFMD_00744 0.0 alsS 2.2.1.6 EH Belongs to the TPP enzyme family
CCEKOFMD_00745 8.6e-61 EGP Major facilitator Superfamily
CCEKOFMD_00746 3.9e-136 speB 3.5.3.11 E hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
CCEKOFMD_00747 7.2e-212 pqqE C radical SAM domain protein
CCEKOFMD_00750 6.7e-156 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
CCEKOFMD_00751 0.0 lepA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
CCEKOFMD_00752 3.9e-19 IQ Acetoin reductase
CCEKOFMD_00753 2.2e-49 IQ Acetoin reductase
CCEKOFMD_00754 1e-47 pspE P Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CCEKOFMD_00755 1.7e-75 ndk 2.7.4.6 F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
CCEKOFMD_00756 7.5e-21 XK27_05470 E Methionine synthase
CCEKOFMD_00757 2.7e-151 XK27_05470 E Methionine synthase
CCEKOFMD_00758 2.1e-257 trmFO 2.1.1.74 J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CCEKOFMD_00759 7.6e-250 T PhoQ Sensor
CCEKOFMD_00760 2.2e-122 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
CCEKOFMD_00761 3.6e-154 S TraX protein
CCEKOFMD_00762 0.0 topA 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CCEKOFMD_00763 8.3e-159 dprA LU DNA protecting protein DprA
CCEKOFMD_00764 1.6e-166 GK ROK family
CCEKOFMD_00765 1.4e-136 rnhB 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CCEKOFMD_00766 3.2e-158 ylqF S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CCEKOFMD_00767 9.8e-88 K DNA-binding helix-turn-helix protein
CCEKOFMD_00768 3e-90 niaR S small molecule binding protein (contains 3H domain)
CCEKOFMD_00769 3.1e-87 niaX
CCEKOFMD_00770 1.6e-272 ffh 3.6.5.4 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CCEKOFMD_00771 1.1e-53 ylxM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CCEKOFMD_00772 2e-126 gntR1 K transcriptional
CCEKOFMD_00773 1.1e-302 guaA 2.3.1.128, 6.3.5.2 F Catalyzes the synthesis of GMP from XMP
CCEKOFMD_00774 0.0 sthIM 2.1.1.72 L Adenine specific DNA methylase Mod
CCEKOFMD_00775 0.0 res_1 3.1.21.5 S Type III restriction
CCEKOFMD_00776 1.1e-20
CCEKOFMD_00778 7.4e-110 adhP 1.1.1.1 C alcohol dehydrogenase
CCEKOFMD_00779 2.3e-62 adhP 1.1.1.1 C alcohol dehydrogenase
CCEKOFMD_00780 2.1e-07
CCEKOFMD_00781 7.3e-110 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CCEKOFMD_00782 2.4e-72 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CCEKOFMD_00783 2.1e-157 aatB ET ABC transporter substrate-binding protein
CCEKOFMD_00784 1.5e-112 glnQ 3.6.3.21 E abc transporter atp-binding protein
CCEKOFMD_00785 4e-105 artQ P ABC transporter (Permease
CCEKOFMD_00786 7.3e-58 phnA P Alkylphosphonate utilization operon protein PhnA
CCEKOFMD_00787 0.0 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
CCEKOFMD_00788 4.5e-166 cpsY K Transcriptional regulator
CCEKOFMD_00789 1.6e-19 L transposase activity
CCEKOFMD_00790 1.6e-118 mur1 NU muramidase
CCEKOFMD_00791 1e-171 yeiH S Membrane
CCEKOFMD_00792 5.8e-09
CCEKOFMD_00793 5.6e-294 adcA P Belongs to the bacterial solute-binding protein 9 family
CCEKOFMD_00794 2.6e-86 XK27_10720 D peptidase activity
CCEKOFMD_00795 3.4e-79 hsdM 2.1.1.72 V HsdM N-terminal domain
CCEKOFMD_00796 1.1e-08 mycA 4.2.1.53 S Myosin-crossreactive antigen
CCEKOFMD_00797 2.3e-151 glcU U Glucose uptake
CCEKOFMD_00798 2.3e-113 hsdM 2.1.1.72 V type I restriction-modification system
CCEKOFMD_00799 8.8e-56 hsdS 2.1.1.72, 3.1.21.3 V type I restriction modification DNA specificity domain
CCEKOFMD_00800 0.0 copB 3.6.3.4 P P-type ATPase
CCEKOFMD_00801 9.4e-43 K Cold-Shock Protein
CCEKOFMD_00802 7.4e-32 cspD K Cold shock protein domain
CCEKOFMD_00803 6.7e-40 pepD E dipeptidase activity
CCEKOFMD_00804 1.5e-138 pepD E Dipeptidase
CCEKOFMD_00805 2.5e-161 whiA K May be required for sporulation
CCEKOFMD_00806 3.6e-182 ybhK S Required for morphogenesis under gluconeogenic growth conditions
CCEKOFMD_00807 2e-163 rapZ S Displays ATPase and GTPase activities
CCEKOFMD_00808 1.2e-135 yejC S cyclic nucleotide-binding protein
CCEKOFMD_00809 2.2e-19 D nuclear chromosome segregation
CCEKOFMD_00810 1.9e-94 queF 1.7.1.13 S Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily
CCEKOFMD_00811 2.5e-135 queE 1.97.1.4, 4.3.99.3 H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
CCEKOFMD_00812 5.7e-82 queD 4.1.2.50, 4.2.3.12 H synthase
CCEKOFMD_00813 9.8e-123 queC 6.3.4.20 F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CCEKOFMD_00814 3e-63 tdcF 3.5.99.10 J endoribonuclease L-PSP
CCEKOFMD_00815 2.7e-31 L Transposase
CCEKOFMD_00816 6.8e-54 L Transposase
CCEKOFMD_00817 2.5e-15
CCEKOFMD_00818 4.2e-261 asnS 6.1.1.22 J Catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
CCEKOFMD_00819 6.5e-218 aspB 2.6.1.1, 2.6.1.14 E Aminotransferase
CCEKOFMD_00820 3.1e-81 ypmB S Protein conserved in bacteria
CCEKOFMD_00821 0.0 dinG 2.7.7.7, 3.6.4.12 L helicase involved in DNA repair and perhaps also replication
CCEKOFMD_00822 4e-121 ycbL 3.1.2.6 S COG0491 Zn-dependent hydrolases, including glyoxylases
CCEKOFMD_00823 4.8e-171 yufQ S Belongs to the binding-protein-dependent transport system permease family
CCEKOFMD_00824 4.7e-191 yufP S Belongs to the binding-protein-dependent transport system permease family
CCEKOFMD_00825 2.7e-280 xylG 3.6.3.17 S ABC transporter, ATP-binding protein
CCEKOFMD_00826 1.5e-189 tcsA S ABC-type transport system, periplasmic component surface lipoprotein
CCEKOFMD_00827 2.2e-47 cdd 2.4.2.2, 3.5.4.5 F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
CCEKOFMD_00828 1.5e-62 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CCEKOFMD_00829 5.5e-29 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CCEKOFMD_00830 7.5e-101 pdp 2.4.2.2, 2.4.2.4 F Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate
CCEKOFMD_00831 1.3e-24 pdp 2.4.2.2, 2.4.2.4 F phosphorylase activity
CCEKOFMD_00832 1.8e-107 rsmC 2.1.1.172 J Methyltransferase small domain protein
CCEKOFMD_00833 2.5e-172 coaA 2.7.1.33 F Pantothenic acid kinase
CCEKOFMD_00834 2.1e-30 rpsT J rRNA binding
CCEKOFMD_00835 5.8e-79 T PhoQ Sensor
CCEKOFMD_00836 1.7e-43 T PhoQ Sensor
CCEKOFMD_00837 2.8e-40 T PhoQ Sensor
CCEKOFMD_00838 6.4e-66 T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
CCEKOFMD_00839 0.0 fhs 6.3.4.3 F Belongs to the formate--tetrahydrofolate ligase family
CCEKOFMD_00840 1.2e-120 coaB 4.1.1.36, 6.3.2.5 H Phosphopantothenate-cysteine ligase
CCEKOFMD_00841 4.8e-94 coaBC 4.1.1.36, 6.3.2.5 H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CCEKOFMD_00842 1.4e-93 panT S ECF transporter, substrate-specific component
CCEKOFMD_00843 0.0 pgm 5.4.2.2, 5.4.2.8 G Phosphoglucomutase
CCEKOFMD_00844 7.3e-166 metF 1.5.1.20 E reductase
CCEKOFMD_00845 0.0 metE 2.1.1.14 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CCEKOFMD_00847 0.0 pabB 2.6.1.85, 4.1.3.27, 4.1.3.38 EH component I
CCEKOFMD_00848 0.0 3.6.3.8 P cation transport ATPase
CCEKOFMD_00849 7.7e-19 L transposase activity
CCEKOFMD_00850 1.1e-156 ugd 1.1.1.22 M Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CCEKOFMD_00851 8.8e-48 ugd 1.1.1.22 M Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CCEKOFMD_00852 8.4e-205 nodC 2.4.1.212 GT2 M Chitin synthase
CCEKOFMD_00853 4.7e-230 dltD M Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CCEKOFMD_00854 1.7e-35 dltC 6.1.1.13 IQ Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
CCEKOFMD_00855 4.6e-238 dltB M Membrane protein involved in D-alanine export
CCEKOFMD_00856 1.6e-296 dltA 6.1.1.13 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
CCEKOFMD_00857 1.7e-09 S D-Ala-teichoic acid biosynthesis protein
CCEKOFMD_00858 0.0 XK27_10035 V abc transporter atp-binding protein
CCEKOFMD_00859 0.0 yfiB1 V abc transporter atp-binding protein
CCEKOFMD_00860 8e-100 pvaA M lytic transglycosylase activity
CCEKOFMD_00861 1.2e-177 ndpA S 37-kD nucleoid-associated bacterial protein
CCEKOFMD_00862 1.8e-234 glyA 2.1.2.1 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CCEKOFMD_00863 2.5e-109 ywlC 2.7.7.87, 3.1.3.48 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
CCEKOFMD_00864 1.2e-154 prmB 2.1.1.297, 2.1.1.298 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
CCEKOFMD_00865 3e-193 prfA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CCEKOFMD_00866 4.5e-111 tdk 2.7.1.21 F thymidine kinase
CCEKOFMD_00867 1.6e-188 add 3.5.4.4 F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CCEKOFMD_00868 1.5e-154 gst O Glutathione S-transferase
CCEKOFMD_00869 3e-184 nrnA 3.1.13.3, 3.1.3.7 S domain protein
CCEKOFMD_00870 9.8e-177 apbE 2.7.1.180 H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
CCEKOFMD_00871 2e-45 rpmE2 J 50S ribosomal protein L31
CCEKOFMD_00872 3.2e-231 mntH P Mn2 and Fe2 transporters of the NRAMP family
CCEKOFMD_00873 8.4e-10
CCEKOFMD_00874 5.5e-30
CCEKOFMD_00875 0.0 ileS 6.1.1.5 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CCEKOFMD_00876 6.7e-135 divIVA D Cell division protein DivIVA
CCEKOFMD_00877 1.2e-143 ylmH T S4 RNA-binding domain
CCEKOFMD_00878 1.2e-34 yggT D integral membrane protein
CCEKOFMD_00879 2e-95 sepF D Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
CCEKOFMD_00880 7.8e-123 ylmE S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CCEKOFMD_00881 5.4e-237 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CCEKOFMD_00882 4.4e-250 ftsA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
CCEKOFMD_00883 8.2e-170 divIB D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
CCEKOFMD_00884 1.3e-201 murG 2.4.1.227 GT28 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CCEKOFMD_00885 1.6e-252 murD 6.3.2.9 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CCEKOFMD_00887 0.0 typA T GTP-binding protein TypA
CCEKOFMD_00888 2.2e-179 glk 2.7.1.2 G Glucokinase
CCEKOFMD_00889 8.4e-28 yqgQ S protein conserved in bacteria
CCEKOFMD_00890 1.1e-80 perR P Belongs to the Fur family
CCEKOFMD_00891 3.5e-91 dps P Belongs to the Dps family
CCEKOFMD_00892 1.5e-115 pilD 3.4.23.43 NOU Bacterial Peptidase A24 N-terminal domain
CCEKOFMD_00893 1.4e-190 3.5.2.6 V D-alanyl-D-alanine carboxypeptidase
CCEKOFMD_00894 1.9e-23 L Transposase
CCEKOFMD_00895 8.5e-113 sodA 1.15.1.1 C radicals which are normally produced within the cells and which are toxic to biological systems
CCEKOFMD_00896 1.2e-183 holA 2.7.7.7 L DNA polymerase III delta subunit
CCEKOFMD_00897 0.0 ppc 4.1.1.31 H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CCEKOFMD_00898 6.2e-56 S Domain of unknown function (DUF4430)
CCEKOFMD_00899 1.8e-73 S Psort location CytoplasmicMembrane, score
CCEKOFMD_00900 1.8e-135 htpX O Belongs to the peptidase M48B family
CCEKOFMD_00901 1.5e-92 lemA S LemA family
CCEKOFMD_00902 4.4e-148 spd F DNA RNA non-specific endonuclease
CCEKOFMD_00903 6.9e-90 S double-stranded DNA endodeoxyribonuclease activity
CCEKOFMD_00904 3.4e-49 S PD-(D/E)XK nuclease family transposase
CCEKOFMD_00905 1.4e-36 prrC S AAA domain
CCEKOFMD_00906 5e-27 prrC S AAA domain
CCEKOFMD_00907 3.1e-53 prrC S AAA domain
CCEKOFMD_00908 2.5e-11 prrC S AAA domain
CCEKOFMD_00909 2.3e-85 3.1.21.3 V type I restriction modification DNA specificity domain
CCEKOFMD_00910 7.3e-289 hsdM 2.1.1.72 V N-6 DNA Methylase
CCEKOFMD_00911 0.0 hsdR 3.1.21.3 V Type I restriction enzyme R protein N terminus (HSDR_N)
CCEKOFMD_00912 1.4e-44 sdh 1.1.1.276, 1.1.1.313, 1.1.1.381 S Belongs to the short-chain dehydrogenases reductases (SDR) family
CCEKOFMD_00913 8.3e-76 sdh 1.1.1.276, 1.1.1.313, 1.1.1.381 S Belongs to the short-chain dehydrogenases reductases (SDR) family
CCEKOFMD_00914 8e-18 MA20_36090 S Protein of unknown function (DUF2974)
CCEKOFMD_00915 1.7e-10 MA20_36090 S Protein of unknown function (DUF2974)
CCEKOFMD_00916 1.4e-113 1.14.14.5 C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CCEKOFMD_00917 2.1e-27 P Hemerythrin HHE cation binding domain protein
CCEKOFMD_00918 5.9e-145 XK27_00880 3.5.1.28 M Glycosyl hydrolase, family 25
CCEKOFMD_00919 7.9e-82 ybaK S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CCEKOFMD_00920 1.5e-115 pgm6 5.4.2.11, 5.4.2.12 G Phosphoglycerate mutase
CCEKOFMD_00921 5.4e-172 S hydrolase
CCEKOFMD_00922 3.1e-20
CCEKOFMD_00923 2.4e-58 M LysM domain
CCEKOFMD_00924 1.9e-15 M LysM domain
CCEKOFMD_00925 9.2e-286 lysS 6.1.1.6 J Belongs to the class-II aminoacyl-tRNA synthetase family
CCEKOFMD_00926 1.2e-33 S SIR2-like domain
CCEKOFMD_00927 5.2e-29 S SIR2-like domain
CCEKOFMD_00928 4.1e-225 mutH L DNA mismatch repair enzyme MutH
CCEKOFMD_00929 6e-209 dcm 2.1.1.37 H C-5 cytosine-specific DNA methylase
CCEKOFMD_00930 4.8e-11
CCEKOFMD_00931 5.1e-235 mntH P H( )-stimulated, divalent metal cation uptake system
CCEKOFMD_00932 1.1e-33 XK27_12190 S protein conserved in bacteria
CCEKOFMD_00934 8.4e-88 bioY S biotin synthase
CCEKOFMD_00935 8.1e-46 S CHY zinc finger
CCEKOFMD_00936 3.4e-252 yegQ O Peptidase U32
CCEKOFMD_00937 2e-177 yegQ O Peptidase U32
CCEKOFMD_00939 5.5e-69 ytxH S General stress protein
CCEKOFMD_00941 4e-147 lgt 2.1.1.199 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CCEKOFMD_00942 1e-170 hprK F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CCEKOFMD_00943 2.2e-41 pspC KT PspC domain
CCEKOFMD_00944 0.0 yhgF K Transcriptional accessory protein
CCEKOFMD_00946 7.1e-156 XK27_03015 S permease
CCEKOFMD_00947 7.8e-146 ycgQ S TIGR03943 family
CCEKOFMD_00948 2.6e-194 S CRISPR-associated protein Csn2 subfamily St
CCEKOFMD_00949 3.1e-53 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CCEKOFMD_00950 4.2e-172 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CCEKOFMD_00951 0.0 cas9 L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
CCEKOFMD_00952 1.4e-94
CCEKOFMD_00953 5.7e-34 estA E GDSL-like Lipase/Acylhydrolase
CCEKOFMD_00954 7.8e-50 dam 2.1.1.72 L D12 class N6 adenine-specific DNA methyltransferase
CCEKOFMD_00955 1e-31 K Cro/C1-type HTH DNA-binding domain
CCEKOFMD_00956 3.2e-46
CCEKOFMD_00957 8.9e-20
CCEKOFMD_00958 3.7e-257 rumA 2.1.1.190 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CCEKOFMD_00959 4.5e-97 mip S hydroperoxide reductase activity
CCEKOFMD_00960 2.4e-203 I acyl-CoA dehydrogenase
CCEKOFMD_00961 2.2e-149 ydiA P C4-dicarboxylate transporter malic acid transport protein
CCEKOFMD_00962 6.4e-252 msrR K Transcriptional regulator
CCEKOFMD_00963 6.7e-153 pheA 4.2.1.51 E Prephenate dehydratase
CCEKOFMD_00964 1.7e-87 aroK 1.1.1.25, 2.7.1.71, 4.2.1.10, 4.2.3.4 F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CCEKOFMD_00965 2.6e-236 aroA 1.3.1.12, 1.3.1.43, 2.5.1.19 E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
CCEKOFMD_00966 3e-173 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
CCEKOFMD_00967 3.2e-53 yheA S Belongs to the UPF0342 family
CCEKOFMD_00968 8.3e-207 tyrA 1.3.1.12, 1.3.1.43 E prephenate dehydrogenase
CCEKOFMD_00969 4.5e-219 aroC 4.2.3.5 E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CCEKOFMD_00970 3.5e-202 aroB 2.7.1.71, 4.2.3.4 E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CCEKOFMD_00971 1.7e-162 aroE 1.1.1.25 E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CCEKOFMD_00972 8.6e-122 aroD 1.1.1.25, 4.2.1.10 E Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
CCEKOFMD_00973 2e-219 ywbD 2.1.1.191 J Methyltransferase
CCEKOFMD_00974 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
CCEKOFMD_00975 2e-25 WQ51_00785
CCEKOFMD_00976 2.8e-246 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
CCEKOFMD_00977 1e-78 yueI S Protein of unknown function (DUF1694)
CCEKOFMD_00978 1.3e-207 glxK 2.7.1.165 G Belongs to the glycerate kinase type-1 family
CCEKOFMD_00979 6.6e-101 yyaQ V Protein conserved in bacteria
CCEKOFMD_00980 2.8e-28 yyaQ S YjbR
CCEKOFMD_00981 4.4e-183 ccpA K Catabolite control protein A
CCEKOFMD_00982 4.2e-211 pepQ 3.4.13.9 E Belongs to the peptidase M24B family
CCEKOFMD_00983 1.7e-63 yugI 5.3.1.9 J RNA binding protein, contains ribosomal protein S1 domain
CCEKOFMD_00984 9.6e-277 ppiB 5.2.1.8 G PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CCEKOFMD_00985 1.1e-80 smpB O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
CCEKOFMD_00986 0.0 rnr J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
CCEKOFMD_00987 2e-33 secG U Preprotein translocase subunit SecG
CCEKOFMD_00988 3.6e-219 mdtG EGP Major facilitator Superfamily
CCEKOFMD_00989 1.3e-105 coaE 2.7.1.24, 3.2.2.23, 4.2.99.18 GH23 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CCEKOFMD_00990 1.9e-155 fpg 3.2.2.23, 4.2.99.18 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
CCEKOFMD_00991 1.3e-165 era M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CCEKOFMD_00992 1.1e-63 dgkA 2.7.1.107, 2.7.1.66 M Diacylglycerol kinase
CCEKOFMD_00993 5.9e-88 ybeY 2.6.99.2, 3.5.4.5 S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CCEKOFMD_00994 6.8e-53 licT K transcriptional antiterminator
CCEKOFMD_00995 5.8e-64 licT K transcriptional antiterminator
CCEKOFMD_00996 4.9e-105 recR L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CCEKOFMD_00997 0.0 pbp2b 3.4.16.4 M penicillin-binding protein
CCEKOFMD_00998 7.8e-149 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CCEKOFMD_00999 3.9e-156 folD 1.5.1.5, 3.5.4.9 F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CCEKOFMD_01000 7.5e-23 I Alpha/beta hydrolase family
CCEKOFMD_01001 1.5e-35 yugF I carboxylic ester hydrolase activity
CCEKOFMD_01002 2.2e-45 K sequence-specific DNA binding
CCEKOFMD_01003 2.4e-104 1.1.1.133, 5.1.3.13 M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
CCEKOFMD_01004 1.5e-07
CCEKOFMD_01005 0.0 feoB P transporter of a GTP-driven Fe(2 ) uptake system
CCEKOFMD_01006 1.1e-78 feoA P FeoA domain protein
CCEKOFMD_01007 2.2e-131 glnQ 3.6.3.21 E abc transporter atp-binding protein
CCEKOFMD_01008 7.5e-118 WQ51_01820 P Binding-protein-dependent transport system inner membrane component
CCEKOFMD_01009 1.3e-34 ykuJ S protein conserved in bacteria
CCEKOFMD_01010 1.2e-180 argF 2.1.3.3 E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CCEKOFMD_01011 0.0 clpE O Belongs to the ClpA ClpB family
CCEKOFMD_01012 1.8e-86 mutT 3.5.4.33, 3.6.1.13, 3.6.1.55 L Belongs to the Nudix hydrolase family
CCEKOFMD_01013 3.7e-48 XK27_09445 S Domain of unknown function (DUF1827)
CCEKOFMD_01014 9.7e-66 S oxidoreductase
CCEKOFMD_01015 9.3e-59 S oxidoreductase
CCEKOFMD_01016 1.3e-232 murN 2.3.2.10, 2.3.2.16 V FemAB family
CCEKOFMD_01017 6.1e-70 M Pfam SNARE associated Golgi protein
CCEKOFMD_01018 2.6e-101 S Domain of Unknown Function with PDB structure (DUF3862)
CCEKOFMD_01021 8.4e-205 rpsA 1.17.7.4 J ribosomal protein S1
CCEKOFMD_01024 4.8e-16 S Protein of unknown function (DUF2969)
CCEKOFMD_01025 2.4e-200 ilvE 2.6.1.42 E Aminotransferase
CCEKOFMD_01026 0.0 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
CCEKOFMD_01027 0.0 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
CCEKOFMD_01028 7.1e-102 plsY 2.3.1.15, 3.5.1.104 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
CCEKOFMD_01029 3.7e-15 L Helix-hairpin-helix DNA-binding motif class 1
CCEKOFMD_01030 1.4e-29 S Domain of unknown function (DUF1912)
CCEKOFMD_01031 4.5e-177 mmuM 1.5.1.20, 2.1.1.10 H Homocysteine
CCEKOFMD_01032 2.2e-249 mmuP E amino acid
CCEKOFMD_01033 3e-110 engB D Necessary for normal cell division and for the maintenance of normal septation
CCEKOFMD_01034 2e-225 clpX O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CCEKOFMD_01035 9.7e-22
CCEKOFMD_01036 3.4e-91 folA 1.5.1.3, 1.5.1.47, 2.1.1.45, 3.5.4.12 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CCEKOFMD_01037 1.5e-166 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CCEKOFMD_01038 1.7e-218 mvaS 2.3.3.10 I synthase
CCEKOFMD_01039 2.7e-233 mvaA 1.1.1.34, 1.1.1.88, 2.3.1.9 C Belongs to the HMG-CoA reductase family
CCEKOFMD_01040 1e-25 K hmm pf08876
CCEKOFMD_01041 1.5e-118 yqfA K protein, Hemolysin III
CCEKOFMD_01042 1.2e-22 S Protein of unknown function (DUF3114)
CCEKOFMD_01043 9.8e-163 S Protein of unknown function (DUF3114)
CCEKOFMD_01044 9.9e-169 S hydrolases or acyltransferases (alpha beta hydrolase superfamily)
CCEKOFMD_01045 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CCEKOFMD_01046 4.9e-21 XK27_13030
CCEKOFMD_01047 1.8e-248 mgs 2.4.1.337 GT4 M Glycosyltransferase, group 1 family protein
CCEKOFMD_01048 1.4e-192 dgs 2.4.1.208 GT4 M Glycosyltransferase, group 1 family protein
CCEKOFMD_01049 1.1e-11 U protein secretion
CCEKOFMD_01050 2.1e-50 U protein secretion
CCEKOFMD_01051 3.5e-07 U protein secretion
CCEKOFMD_01053 5.9e-118 mtnN 3.2.2.9 E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CCEKOFMD_01054 2.5e-21
CCEKOFMD_01055 1e-96 nudF 3.6.1.13 L AdP-ribose pyrophosphatase
CCEKOFMD_01056 5.1e-254 glmU 2.3.1.157, 2.7.7.23 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CCEKOFMD_01057 3.4e-191 fni 1.1.1.88, 5.3.3.2 C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
CCEKOFMD_01058 5e-179 mvaK2 2.7.1.36, 2.7.1.43, 2.7.4.2 I GHMP kinases N terminal domain
CCEKOFMD_01059 1.3e-173 mvaD 4.1.1.33 I diphosphomevalonate decarboxylase
CCEKOFMD_01060 6.9e-140 mvk 1.1.1.88, 2.3.3.10, 2.7.1.36 I mevalonate kinase
CCEKOFMD_01061 4.6e-105 GBS0088 J protein conserved in bacteria
CCEKOFMD_01062 5.7e-247 merA 1.16.1.1 C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CCEKOFMD_01063 5.9e-47 ald 1.4.1.1 C Belongs to the AlaDH PNT family
CCEKOFMD_01064 3.4e-17 ald 1.4.1.1 E alanine dehydrogenase activity
CCEKOFMD_01065 4e-220 hipO 3.5.1.47 E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
CCEKOFMD_01066 7.4e-132 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
CCEKOFMD_01067 9.6e-113 S VIT family
CCEKOFMD_01068 1.8e-144 deoD_1 2.4.2.3 F Phosphorylase superfamily
CCEKOFMD_01069 1.9e-22
CCEKOFMD_01070 8e-28 XK27_00085 K Transcriptional
CCEKOFMD_01071 6.9e-197 yceA S Belongs to the UPF0176 family
CCEKOFMD_01072 5.4e-122 sagI S ABC-2 type transporter
CCEKOFMD_01073 2.8e-168 V ABC transporter
CCEKOFMD_01074 2.5e-219 2.7.7.73, 2.7.7.80 H Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
CCEKOFMD_01075 2.5e-132 rr02 KT response regulator
CCEKOFMD_01076 3.3e-215 2.7.13.3 T signal transduction protein with a C-terminal ATPase domain
CCEKOFMD_01077 2.6e-121 nagB 3.1.1.31, 3.5.99.6 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
CCEKOFMD_01078 6e-199 queA 2.4.99.17 J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CCEKOFMD_01079 0.0 lmrA V abc transporter atp-binding protein
CCEKOFMD_01080 0.0 mdlB V abc transporter atp-binding protein
CCEKOFMD_01082 3.9e-52 rplL J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
CCEKOFMD_01083 5.6e-78 rplJ J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CCEKOFMD_01084 7.2e-24 ytrF V efflux transmembrane transporter activity
CCEKOFMD_01085 4.6e-43 V efflux transmembrane transporter activity
CCEKOFMD_01086 1.7e-59 V permease protein
CCEKOFMD_01087 6.9e-37 acrA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CCEKOFMD_01088 7.6e-21 acrA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CCEKOFMD_01089 5.1e-131 2.1.1.223 S Putative SAM-dependent methyltransferase
CCEKOFMD_01090 0.0 carB 6.3.5.5 F carbamoyl-phosphate synthetase ammonia chain
CCEKOFMD_01091 1.1e-211 carA 6.3.5.5 F carbamoyl-phosphate synthetase glutamine chain
CCEKOFMD_01092 1e-173 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
CCEKOFMD_01093 1.1e-226 pyrP F uracil Permease
CCEKOFMD_01094 3.7e-88 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CCEKOFMD_01095 4.5e-163 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
CCEKOFMD_01096 1.5e-77 lspA 3.4.23.36 MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CCEKOFMD_01097 1.4e-167 fhuR K transcriptional regulator (lysR family)
CCEKOFMD_01102 3.2e-141 ppiA 5.2.1.8 O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CCEKOFMD_01103 9.7e-77 2.7.1.199, 2.7.1.211 G PTS glucose transporter subunit IIA
CCEKOFMD_01104 2.5e-119 pts33BCA G pts system
CCEKOFMD_01105 1.7e-70 pts33BCA G pts system
CCEKOFMD_01106 2.4e-09 uvrX 2.7.7.7 L impB/mucB/samB family
CCEKOFMD_01107 1.8e-254 cycA E permease
CCEKOFMD_01108 4.5e-39 ynzC S UPF0291 protein
CCEKOFMD_01109 0.0 glyS 6.1.1.14 J Glycyl-tRNA synthetase beta subunit
CCEKOFMD_01110 4.8e-176 glyQ 6.1.1.14 J glycyl-tRNA synthetase alpha subunit
CCEKOFMD_01111 6.1e-63 S membrane
CCEKOFMD_01112 1.5e-59
CCEKOFMD_01113 7.5e-26
CCEKOFMD_01114 1.8e-53
CCEKOFMD_01115 2.1e-221 nagA 3.5.1.25 G Belongs to the metallo-dependent hydrolases superfamily. NagA family
CCEKOFMD_01116 2.9e-68 nptA P sodium-dependent phosphate transmembrane transporter activity
CCEKOFMD_01117 2.2e-148 XK27_04800 S Sucrose-6F-phosphate phosphohydrolase
CCEKOFMD_01118 3.2e-105 mur1 NU mannosyl-glycoprotein
CCEKOFMD_01119 6.6e-54 glnB K Belongs to the P(II) protein family
CCEKOFMD_01120 5.8e-233 amt P Ammonium Transporter
CCEKOFMD_01121 2.7e-160 rsmI 2.1.1.198 H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CCEKOFMD_01122 9.5e-55 yabA L Involved in initiation control of chromosome replication
CCEKOFMD_01123 1.2e-135 yaaT S stage 0 sporulation protein
CCEKOFMD_01124 6.4e-162 holB 2.7.7.7 L dna polymerase iii
CCEKOFMD_01125 1.7e-111 tmk 2.7.4.9 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CCEKOFMD_01126 1.4e-136 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
CCEKOFMD_01127 9.5e-225 tuf J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CCEKOFMD_01128 2.8e-230 ftsW D Belongs to the SEDS family
CCEKOFMD_01129 2e-66 atpC C Produces ATP from ADP in the presence of a proton gradient across the membrane
CCEKOFMD_01130 2.7e-263 atpD 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CCEKOFMD_01131 9.6e-158 atpG C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CCEKOFMD_01132 3.8e-279 atpA 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CCEKOFMD_01133 3.5e-86 atpH C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CCEKOFMD_01134 3.3e-78 atpF C ATP synthase F(0) sector subunit b
CCEKOFMD_01135 9e-122 atpB C it plays a direct role in the translocation of protons across the membrane
CCEKOFMD_01136 3.2e-16 atpE C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CCEKOFMD_01137 0.0 valS 6.1.1.9 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
CCEKOFMD_01138 1.9e-46 2.3.1.128, 5.2.1.8 J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CCEKOFMD_01139 1.1e-89 S COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CCEKOFMD_01140 8.9e-14 coiA 3.6.4.12 S Competence protein
CCEKOFMD_01141 2.2e-15 T peptidase
CCEKOFMD_01142 3e-151 rarD S Transporter
CCEKOFMD_01143 1.1e-153 thrB 2.7.1.39 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
CCEKOFMD_01144 1.8e-237 hom 1.1.1.3, 2.7.2.4 E homoserine dehydrogenase
CCEKOFMD_01145 7.9e-128 yxkH G deacetylase
CCEKOFMD_01146 1.2e-208 argD 2.6.1.11, 2.6.1.17 E acetylornithine aminotransferase
CCEKOFMD_01147 1.3e-128 argB 2.7.2.8 E Belongs to the acetylglutamate kinase family. ArgB subfamily
CCEKOFMD_01148 1.5e-222 argJ 2.3.1.1, 2.3.1.35, 2.7.2.8 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CCEKOFMD_01149 1.7e-190 argC 1.2.1.38 E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CCEKOFMD_01150 1.7e-226 mtnE 2.6.1.83 E mutations do not affect methionine salvage in vivo however
CCEKOFMD_01151 2.6e-146 cnhA 3.5.1.3 S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
CCEKOFMD_01152 6.4e-52 3.4.17.14, 3.5.1.28 NU amidase activity
CCEKOFMD_01153 1.5e-23 3.4.17.14, 3.5.1.28 NU amidase activity
CCEKOFMD_01154 2.7e-14 vanY 3.4.17.14, 3.5.1.28 M D-alanyl-D-alanine carboxypeptidase
CCEKOFMD_01155 3e-63 3.4.17.14, 3.5.1.28 NU amidase activity
CCEKOFMD_01156 6.2e-84 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
CCEKOFMD_01157 7.9e-24 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
CCEKOFMD_01158 0.0 alaS 6.1.1.7 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CCEKOFMD_01159 1.1e-166 prsA 3.1.3.16, 5.2.1.8 O peptidyl-prolyl cis-trans isomerase activity
CCEKOFMD_01160 5.4e-127 yrrM 2.1.1.104 S O-Methyltransferase
CCEKOFMD_01161 0.0 pepF E oligoendopeptidase F
CCEKOFMD_01162 1.4e-186 coiA 3.6.4.12 S Competence protein
CCEKOFMD_01163 1.8e-164 K transcriptional regulator (lysR family)
CCEKOFMD_01164 0.0 metG 6.1.1.10, 6.1.1.20 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CCEKOFMD_01168 1e-190 phoH T phosphate starvation-inducible protein PhoH
CCEKOFMD_01169 2.2e-118 sip M LysM domain protein
CCEKOFMD_01170 7.4e-35 yozE S Belongs to the UPF0346 family
CCEKOFMD_01171 5.3e-161 cvfB S Protein conserved in bacteria
CCEKOFMD_01172 1.3e-91 frr J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
CCEKOFMD_01173 4.9e-131 pyrH 2.7.4.22 F Catalyzes the reversible phosphorylation of UMP to UDP
CCEKOFMD_01174 4.5e-77 sptS 2.7.13.3 T Histidine kinase
CCEKOFMD_01175 7.1e-37 K Acetyltransferase (GNAT) family
CCEKOFMD_01176 0.0 lmrA2 V abc transporter atp-binding protein
CCEKOFMD_01177 0.0 lmrA1 V abc transporter atp-binding protein
CCEKOFMD_01178 1.9e-77 K DNA-binding transcription factor activity
CCEKOFMD_01179 1e-69 def_1 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins
CCEKOFMD_01180 1.8e-256 gdhA 1.4.1.4 E Belongs to the Glu Leu Phe Val dehydrogenases family
CCEKOFMD_01181 1.7e-212 nadD 2.7.1.22, 2.7.7.1, 2.7.7.18, 3.6.1.55 H adenylyltransferase
CCEKOFMD_01182 1.1e-141 3.6.1.13, 3.6.1.55 F AdP-ribose pyrophosphatase
CCEKOFMD_01183 1.6e-24 U response to pH
CCEKOFMD_01184 0.0 yfmR S abc transporter atp-binding protein
CCEKOFMD_01185 1.5e-225 cca 2.7.7.19, 2.7.7.72 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
CCEKOFMD_01186 3e-139 dapB 1.17.1.8 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
CCEKOFMD_01187 3.6e-74 XK27_08360 S EDD domain protein, DegV family
CCEKOFMD_01188 1.9e-60 XK27_08360 S EDD domain protein, DegV family
CCEKOFMD_01189 2.3e-60 WQ51_03320 S cog cog4835
CCEKOFMD_01190 3e-122 ydaF_2 J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CCEKOFMD_01191 1.5e-46 rpmA J Belongs to the bacterial ribosomal protein bL27 family
CCEKOFMD_01192 1.7e-48 rplU J This protein binds to 23S rRNA in the presence of protein L20
CCEKOFMD_01193 6.4e-29 2.3.1.128 K acetyltransferase
CCEKOFMD_01194 4.9e-39 2.3.1.128 K acetyltransferase
CCEKOFMD_01195 3e-256 gtf2 M A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1
CCEKOFMD_01196 1.4e-294 gtf1 2.4.1.52 GT4 M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
CCEKOFMD_01197 2.5e-228 thiI 2.8.1.4 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CCEKOFMD_01198 6.1e-213 iscS2 2.8.1.7 E Cysteine sulfinate desulfinase cysteine desulfurase and related enzymes
CCEKOFMD_01200 3.4e-241 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
CCEKOFMD_01201 3.2e-261 gor 1.8.1.7 C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CCEKOFMD_01202 2.7e-102 fruA 2.7.1.202 G phosphotransferase system
CCEKOFMD_01203 2.3e-25 fruA 2.7.1.202 G phosphotransferase system
CCEKOFMD_01204 7.8e-22 fruA 2.7.1.202 GT PTS system, Lactose/Cellobiose specific IIB subunit
CCEKOFMD_01205 1.6e-78 fruA 2.7.1.202 GT PTS system, Lactose/Cellobiose specific IIB subunit
CCEKOFMD_01206 4.6e-163 pfkB 2.7.1.11, 2.7.1.56 H Belongs to the carbohydrate kinase PfkB family. LacC subfamily
CCEKOFMD_01207 2.1e-113 fruR K transcriptional
CCEKOFMD_01208 1.8e-84 L Transposase
CCEKOFMD_01209 1.8e-170 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
CCEKOFMD_01210 7.4e-186 gpsA 1.1.1.94 I Glycerol-3-phosphate dehydrogenase
CCEKOFMD_01211 2.2e-27 XK27_08585 S Psort location CytoplasmicMembrane, score
CCEKOFMD_01212 1.2e-23 XK27_08585 S Psort location CytoplasmicMembrane, score
CCEKOFMD_01213 2.1e-115 fnt P Formate nitrite transporter
CCEKOFMD_01214 4.7e-213 XK27_09615 C reductase
CCEKOFMD_01215 6.2e-76 XK27_09620 S reductase
CCEKOFMD_01216 4.7e-20 XK27_09620 S FMN reductase (NADPH) activity
CCEKOFMD_01217 5.4e-80 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
CCEKOFMD_01218 1.4e-226 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CCEKOFMD_01219 6.2e-12 WQ51_05710 S Mitochondrial biogenesis AIM24
CCEKOFMD_01220 7.3e-59 WQ51_05710 S Mitochondrial biogenesis AIM24
CCEKOFMD_01221 2e-88 cah 4.2.1.1 P Reversible hydration of carbon dioxide
CCEKOFMD_01222 3.5e-50 S Protein of unknown function (DUF3397)
CCEKOFMD_01223 3.7e-70 rplK J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CCEKOFMD_01224 4.8e-120 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
CCEKOFMD_01225 4.2e-74 amiA E transmembrane transport
CCEKOFMD_01226 2.2e-79 amiA E transmembrane transport
CCEKOFMD_01227 1.8e-281 gltX 6.1.1.17, 6.1.1.24 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CCEKOFMD_01228 2e-230 argG 6.3.4.5 E Belongs to the argininosuccinate synthase family. Type 1 subfamily
CCEKOFMD_01229 1.9e-264 argH 4.3.2.1 E Argininosuccinate lyase
CCEKOFMD_01230 1.2e-55 rnpA 3.1.26.5 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
CCEKOFMD_01231 2.8e-124 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
CCEKOFMD_01232 2.5e-59 L COG2801 Transposase and inactivated derivatives
CCEKOFMD_01233 3.2e-113 K sequence-specific DNA binding
CCEKOFMD_01234 6.4e-85 C Arylsulfatase regulator (Fe-S oxidoreductase)
CCEKOFMD_01235 1.4e-74 C Arylsulfatase regulator (Fe-S oxidoreductase)
CCEKOFMD_01236 5.1e-113 V (ABC) transporter
CCEKOFMD_01237 7.3e-55 V (ABC) transporter
CCEKOFMD_01238 1.7e-51 2.3.1.128 K Acetyltransferase GNAT Family
CCEKOFMD_01239 8e-277 S Protein of unknown function (DUF3114)
CCEKOFMD_01241 3.4e-35 tnp L Transposase
CCEKOFMD_01242 1.3e-07 L Transposase and inactivated derivatives, TnpA family
CCEKOFMD_01243 4.4e-176 gadC E Psort location CytoplasmicMembrane, score 10.00
CCEKOFMD_01244 2.3e-214 gadB 4.1.1.15 E Belongs to the group II decarboxylase family
CCEKOFMD_01245 1.1e-65 tnp L Transposase
CCEKOFMD_01246 4.7e-90 luxS 4.4.1.21 H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
CCEKOFMD_01247 1.1e-138 accA 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
CCEKOFMD_01248 1.6e-160 accD 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CCEKOFMD_01249 1.7e-257 accC 6.3.4.14, 6.4.1.2 I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
CCEKOFMD_01250 1.5e-71 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
CCEKOFMD_01251 7.7e-56 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
CCEKOFMD_01252 2.6e-233 fabF 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
CCEKOFMD_01253 1.6e-126 IQ reductase
CCEKOFMD_01254 8.5e-165 fabD 2.3.1.39 I Malonyl CoA-acyl carrier protein transacylase
CCEKOFMD_01255 5.8e-172 fabK 1.3.1.9 S 2-Nitropropane dioxygenase
CCEKOFMD_01256 3.3e-30 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
CCEKOFMD_01257 2.3e-173 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CCEKOFMD_01258 4e-72 marR K Transcriptional regulator, MarR family
CCEKOFMD_01259 2.4e-139 phaB 5.3.3.14, 5.3.3.18 I Belongs to the enoyl-CoA hydratase isomerase family
CCEKOFMD_01260 1.9e-115 S Haloacid dehalogenase-like hydrolase
CCEKOFMD_01261 2.4e-256 lysC 2.7.2.4 E Belongs to the aspartokinase family
CCEKOFMD_01262 8e-193 asnA 6.3.1.1 E aspartate--ammonia ligase
CCEKOFMD_01263 6.7e-259 rumA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CCEKOFMD_01264 1.2e-130 recX 2.4.1.337 GT4 S Regulatory protein RecX
CCEKOFMD_01265 7.8e-102 ygaC J Belongs to the UPF0374 family
CCEKOFMD_01266 6.4e-108 S Domain of unknown function (DUF1803)
CCEKOFMD_01267 2.1e-166 ppaC 3.6.1.1 C inorganic pyrophosphatase
CCEKOFMD_01274 2.1e-94 hpf J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CCEKOFMD_01275 1.7e-122 comFC S Competence protein
CCEKOFMD_01276 4.5e-252 comFA L Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CCEKOFMD_01277 1.1e-110 yvyE 3.4.13.9 S YigZ family
CCEKOFMD_01278 3.7e-168 cysK 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
CCEKOFMD_01279 8.9e-41 acuB S IMP dehydrogenase activity
CCEKOFMD_01280 6.8e-69 acuB S IMP dehydrogenase activity
CCEKOFMD_01281 4.8e-123 livF E COG0410 ABC-type branched-chain amino acid transport systems, ATPase component
CCEKOFMD_01282 9.6e-138 livG E COG0411 ABC-type branched-chain amino acid transport systems, ATPase component
CCEKOFMD_01283 1.4e-138 livM E Belongs to the binding-protein-dependent transport system permease family
CCEKOFMD_01284 1.9e-145 livH E Belongs to the binding-protein-dependent transport system permease family
CCEKOFMD_01285 1.8e-212 livJ E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component
CCEKOFMD_01286 7.1e-46 ylbG S UPF0298 protein
CCEKOFMD_01287 1.2e-74 ylbF S Belongs to the UPF0342 family
CCEKOFMD_01288 2.9e-105 clpP 3.4.21.92 OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
CCEKOFMD_01289 5.7e-112 upp 2.4.2.9 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CCEKOFMD_01292 1e-223 malY 4.4.1.8 E COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
CCEKOFMD_01293 4.7e-202 metB 2.5.1.48, 4.4.1.8 E cystathionine
CCEKOFMD_01294 3.3e-96 pacL 3.6.3.8, 3.6.3.9 P cation transport ATPase
CCEKOFMD_01295 4.5e-283 ytgP S Membrane protein involved in the export of O-antigen and teichoic acid
CCEKOFMD_01296 4.9e-276 murE 6.3.2.13, 6.3.2.7 M to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CCEKOFMD_01297 6e-157 femA 2.3.2.10, 2.3.2.16, 2.3.2.17, 2.3.2.18 V protein involved in methicillin resistance
CCEKOFMD_01298 8.7e-41 femA 2.3.2.10, 2.3.2.16, 2.3.2.17, 2.3.2.18 V protein involved in methicillin resistance
CCEKOFMD_01299 3.4e-37 yvdD 3.2.2.10 L Belongs to the LOG family
CCEKOFMD_01300 2e-22 yvdD 3.2.2.10 S Belongs to the LOG family
CCEKOFMD_01301 1.7e-57 rbfA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CCEKOFMD_01302 0.0 infB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CCEKOFMD_01303 1.4e-41 ylxQ J ribosomal protein
CCEKOFMD_01304 1e-47 ylxR K Nucleic-acid-binding protein implicated in transcription termination
CCEKOFMD_01305 3.1e-212 nusA K Participates in both transcription termination and antitermination
CCEKOFMD_01306 3.9e-81 rimP S Required for maturation of 30S ribosomal subunits
CCEKOFMD_01307 2.8e-219 brpA K Transcriptional
CCEKOFMD_01308 3.2e-92 XK27_05885 2.3.1.82 M Acetyltransferase GNAT Family
CCEKOFMD_01309 1.4e-77 ydiB 2.7.1.221, 5.1.1.1 M ATPase or kinase
CCEKOFMD_01310 1.9e-248 pbuO S permease
CCEKOFMD_01311 1e-153 yitU 3.1.3.104 S hydrolases of the HAD superfamily
CCEKOFMD_01312 1.5e-140 XK27_00940 1.2.1.70, 3.5.1.9 S Metal-dependent hydrolase
CCEKOFMD_01313 1.1e-181 manL 2.7.1.191 G pts system
CCEKOFMD_01314 2.3e-116 manM G pts system
CCEKOFMD_01315 6.2e-168 manN G PTS system mannose fructose sorbose family IID component
CCEKOFMD_01316 4.2e-62 manO S protein conserved in bacteria
CCEKOFMD_01317 8.6e-232 serS 6.1.1.11 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CCEKOFMD_01318 7.8e-28 L transposase activity
CCEKOFMD_01319 2.5e-23 L Transposase
CCEKOFMD_01320 3.4e-50 L transposition
CCEKOFMD_01321 3e-27 L Integrase core domain protein
CCEKOFMD_01322 6.7e-14 yrdC 3.5.1.19 Q isochorismatase
CCEKOFMD_01323 1.2e-34
CCEKOFMD_01325 2.6e-247 der 1.1.1.399, 1.1.1.95 S GTPase that plays an essential role in the late steps of ribosome biogenesis
CCEKOFMD_01326 4.4e-166 dnaI L Primosomal protein DnaI
CCEKOFMD_01327 6.5e-218 dnaB L Replication initiation and membrane attachment
CCEKOFMD_01328 4.7e-82 nrdR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CCEKOFMD_01329 2.8e-282 T PhoQ Sensor
CCEKOFMD_01330 1.8e-122 T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
CCEKOFMD_01331 2.1e-91 yceD K metal-binding, possibly nucleic acid-binding protein
CCEKOFMD_01332 1.2e-129 rsmG 2.1.1.170 J Ribosomal RNA small subunit methyltransferase G
CCEKOFMD_01333 2.7e-244 P COG0168 Trk-type K transport systems, membrane components
CCEKOFMD_01334 1.4e-121 ktrA P COG0569 K transport systems, NAD-binding component
CCEKOFMD_01335 6.9e-11 ulaG S L-ascorbate 6-phosphate lactonase
CCEKOFMD_01336 0.0 tkt 2.2.1.1 G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CCEKOFMD_01337 4.7e-146 cbiQ P cobalt transport
CCEKOFMD_01338 0.0 ykoD P abc transporter atp-binding protein
CCEKOFMD_01339 9.4e-95 S UPF0397 protein
CCEKOFMD_01340 4.7e-157 salL 2.5.1.63, 2.5.1.94 S S-adenosyl-l-methionine hydroxide adenosyltransferase
CCEKOFMD_01341 6.1e-211 sstT E Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CCEKOFMD_01342 8.8e-98 metI P ABC transporter (Permease
CCEKOFMD_01343 7.5e-189 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CCEKOFMD_01344 1e-63 dapE 3.5.1.18 E succinyl-diaminopimelate desuccinylase activity
CCEKOFMD_01345 1.4e-62 dapE 3.5.1.18 E succinyl-diaminopimelate desuccinylase activity
CCEKOFMD_01346 7.1e-86 dapE 3.5.1.18 E COG0624, acetylornithine deacetylase succinyl-diaminopimelate desuccinylase and related deacylases
CCEKOFMD_01347 3.7e-165 metQ M Belongs to the NlpA lipoprotein family
CCEKOFMD_01348 4e-153 ET amino acid transport
CCEKOFMD_01349 3.8e-205 EGP Transmembrane secretion effector
CCEKOFMD_01350 0.0 3.3.1.1, 3.6.1.55, 3.6.1.67 F NUDIX domain
CCEKOFMD_01351 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
CCEKOFMD_01352 3.8e-151 ET amino acid transport
CCEKOFMD_01353 1.6e-131 cbiO P ABC transporter
CCEKOFMD_01354 1.1e-136 P cobalt transport protein
CCEKOFMD_01355 4.3e-175 cbiM P PDGLE domain
CCEKOFMD_01356 8.9e-161 ureD O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
CCEKOFMD_01357 9.5e-112 ureG KO Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CCEKOFMD_01358 5.3e-130 ureF O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
CCEKOFMD_01359 6.6e-78 ureE O enzyme active site formation
CCEKOFMD_01360 0.0 ureC 3.5.1.5 E Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family
CCEKOFMD_01361 7.8e-54 ureB 3.5.1.5 E Belongs to the urease beta subunit family
CCEKOFMD_01362 7.6e-46 ureA 3.5.1.5 E Belongs to the urease gamma subunit family
CCEKOFMD_01363 6.8e-95 ureI S AmiS/UreI family transporter
CCEKOFMD_01364 9.2e-132 S Domain of unknown function (DUF4173)
CCEKOFMD_01365 3.7e-51 yhaI L Membrane
CCEKOFMD_01366 3.4e-68 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
CCEKOFMD_01367 1.8e-27 comA V protein secretion by the type I secretion system
CCEKOFMD_01368 1.1e-34 V protein secretion by the type I secretion system
CCEKOFMD_01369 4.3e-57 V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
CCEKOFMD_01370 7.4e-36 V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
CCEKOFMD_01371 1.2e-32 V protein secretion by the type I secretion system
CCEKOFMD_01372 5.6e-161 K sequence-specific DNA binding
CCEKOFMD_01373 4.8e-114 bcrC 3.6.1.27 I Membrane-associated phospholipid phosphatase
CCEKOFMD_01374 3.2e-90 ribU U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CCEKOFMD_01375 7.9e-96 trmL 2.1.1.207 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
CCEKOFMD_01376 1.5e-247 trkA P Potassium transporter peripheral membrane component
CCEKOFMD_01377 1.2e-258 trkH P Cation transport protein
CCEKOFMD_01378 1.8e-40 yidD S Could be involved in insertion of integral membrane proteins into the membrane
CCEKOFMD_01379 6.1e-140 rluB 5.4.99.19, 5.4.99.21, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
CCEKOFMD_01380 3e-99 scpB D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CCEKOFMD_01381 3.1e-122 scpA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CCEKOFMD_01382 3.7e-137 xerD L tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site
CCEKOFMD_01383 2.1e-85 ykuL S CBS domain
CCEKOFMD_01384 3.5e-99 XK27_09740 S Phosphoesterase
CCEKOFMD_01385 6e-185 rdgB 3.6.1.66, 5.1.1.3 F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CCEKOFMD_01386 4.2e-147 murI 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
CCEKOFMD_01387 7.6e-36 yneF S UPF0154 protein
CCEKOFMD_01388 1.4e-90 K transcriptional regulator
CCEKOFMD_01389 9.6e-244 lysA 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
CCEKOFMD_01392 8.8e-98 ybhL S Belongs to the BI1 family
CCEKOFMD_01393 6.1e-93 XK27_09705 6.1.1.14 S HD superfamily hydrolase
CCEKOFMD_01394 6.4e-131 spoU 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CCEKOFMD_01395 7e-46 acyP 3.6.1.7 C Belongs to the acylphosphatase family
CCEKOFMD_01396 8.5e-165 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
CCEKOFMD_01397 5.2e-59 L Integrase core domain protein
CCEKOFMD_01398 1.6e-77 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
CCEKOFMD_01399 0.0 mltG ADL Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CCEKOFMD_01400 9.3e-46 XK27_09675 K -acetyltransferase
CCEKOFMD_01401 2.6e-255 mpl 6.3.2.4, 6.3.2.45, 6.3.2.8 M Belongs to the MurCDEF family
CCEKOFMD_01402 2.5e-23
CCEKOFMD_01403 0.0 snf 2.7.11.1 L Superfamily II DNA RNA helicases, SNF2 family'
CCEKOFMD_01404 2.5e-296 mapZ D Early cell division protein that marks the future cell division site and supports proper FtsZ ring positioning
CCEKOFMD_01405 1.5e-222 rlmL 2.1.1.173, 2.1.1.264 L Belongs to the methyltransferase superfamily
CCEKOFMD_01406 2.5e-50 gpsB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
CCEKOFMD_01407 3.1e-95 ypsA S Belongs to the UPF0398 family
CCEKOFMD_01408 2.5e-109 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
CCEKOFMD_01409 0.0 ponA 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
CCEKOFMD_01410 1.5e-258 pepC 3.4.22.40 E aminopeptidase
CCEKOFMD_01411 1.9e-77 yhaI L Membrane
CCEKOFMD_01412 2.1e-151 nadE 6.3.1.5 H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
CCEKOFMD_01413 5.7e-280 pncB 6.3.4.21 H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CCEKOFMD_01414 1e-139 S COG1073 Hydrolases of the alpha beta superfamily
CCEKOFMD_01415 2.6e-76 S thiolester hydrolase activity
CCEKOFMD_01417 3.8e-40 K transcriptional
CCEKOFMD_01419 0.0 leuS 6.1.1.4 J Belongs to the class-I aminoacyl-tRNA synthetase family
CCEKOFMD_01420 3.9e-21 glcR K transcriptional regulator (DeoR family)
CCEKOFMD_01421 4.7e-79 glcR K transcriptional regulator (DeoR family)
CCEKOFMD_01422 1.1e-34 cof Q phosphatase activity
CCEKOFMD_01423 6e-55 cof Q phosphatase activity
CCEKOFMD_01424 4.6e-85 3.1.3.27, 3.1.3.4, 3.1.3.81, 3.6.1.27 I phosphatidate phosphatase activity
CCEKOFMD_01425 8.4e-96 nusG K Participates in transcription elongation, termination and antitermination
CCEKOFMD_01426 5.7e-25 secE U Belongs to the SecE SEC61-gamma family
CCEKOFMD_01427 0.0 pbp2A 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
CCEKOFMD_01428 1.2e-165 rluA 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
CCEKOFMD_01429 6.8e-56 S TM2 domain
CCEKOFMD_01430 4.7e-43
CCEKOFMD_01433 2.1e-82 L Integrase core domain protein
CCEKOFMD_01434 8.7e-31 L transposition
CCEKOFMD_01435 6.4e-18 L transposase activity
CCEKOFMD_01436 4.4e-37 L Transposase
CCEKOFMD_01437 4.1e-287 groL O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
CCEKOFMD_01438 1.3e-42 groS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CCEKOFMD_01439 5.2e-142 cmpC S abc transporter atp-binding protein
CCEKOFMD_01440 0.0 WQ51_06230 S ABC transporter substrate binding protein
CCEKOFMD_01441 0.0 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
CCEKOFMD_01442 1.4e-231 rseP 3.4.21.107, 3.4.21.116 M zinc metalloprotease
CCEKOFMD_01443 2.2e-145 cdsA 2.7.7.41 S Belongs to the CDS family
CCEKOFMD_01444 1.1e-141 uppS 2.5.1.31 H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CCEKOFMD_01445 9.8e-50 yajC U protein transport
CCEKOFMD_01446 1.9e-127 yeeN K transcriptional regulatory protein
CCEKOFMD_01447 8.1e-257 pgi 5.3.1.9 G Belongs to the GPI family
CCEKOFMD_01448 6.8e-158 rgfB 3.1.3.90 L Endonuclease/Exonuclease/phosphatase family
CCEKOFMD_01449 1.5e-104 ptsG 2.7.1.199, 2.7.1.208, 2.7.1.211 G phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1
CCEKOFMD_01450 5.1e-149 ptsG 2.7.1.199, 2.7.1.208, 2.7.1.211 G pts system
CCEKOFMD_01451 5.6e-65 ptsG 2.7.1.199, 2.7.1.208 G pts system
CCEKOFMD_01452 1.4e-162 mleP2 S Transporter, auxin efflux carrier (AEC) family protein
CCEKOFMD_01453 2.5e-128 adcB P ABC transporter (Permease
CCEKOFMD_01454 6.4e-136 adcC P ABC transporter, ATP-binding protein
CCEKOFMD_01455 3.1e-72 adcR K transcriptional
CCEKOFMD_01456 1.9e-223 EGP Major facilitator Superfamily
CCEKOFMD_01457 0.0 KLT serine threonine protein kinase
CCEKOFMD_01459 6e-128 K sequence-specific DNA binding
CCEKOFMD_01460 7.4e-183 dus J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CCEKOFMD_01461 2.1e-157 hslO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CCEKOFMD_01462 2.7e-21
CCEKOFMD_01463 9.8e-62 oppF P Belongs to the ABC transporter superfamily
CCEKOFMD_01464 7.5e-62 oppF P Belongs to the ABC transporter superfamily
CCEKOFMD_01465 3.1e-43 oppD P Belongs to the ABC transporter superfamily
CCEKOFMD_01466 1.2e-62 oppD P Belongs to the ABC transporter superfamily
CCEKOFMD_01467 1.7e-62 oppD P Belongs to the ABC transporter superfamily
CCEKOFMD_01468 1.4e-38 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
CCEKOFMD_01469 2.5e-09 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
CCEKOFMD_01470 1.7e-33 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
CCEKOFMD_01471 6.6e-11 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
CCEKOFMD_01472 4.2e-27 oppB P ABC-type dipeptide oligopeptide nickel transport systems, permease components
CCEKOFMD_01473 2.3e-139 oppA E ABC transporter substrate-binding protein
CCEKOFMD_01474 7e-10 oppA E ABC transporter substrate-binding protein
CCEKOFMD_01475 2.2e-273 sufB O assembly protein SufB
CCEKOFMD_01476 1.2e-73 nifU C SUF system FeS assembly protein, NifU family
CCEKOFMD_01477 7.7e-238 sufS 2.8.1.7, 4.4.1.16 E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CCEKOFMD_01478 6.3e-235 sufD O assembly protein SufD
CCEKOFMD_01479 9.5e-144 sufC O ABC-type transport system involved in Fe-S cluster assembly, ATPase component
CCEKOFMD_01480 7.1e-185 tagO 2.7.8.33, 2.7.8.35 M transferase
CCEKOFMD_01481 5.2e-136 mecA NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
CCEKOFMD_01482 9.1e-153 uppP 3.6.1.27 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
CCEKOFMD_01483 5.8e-275 glnP P ABC transporter
CCEKOFMD_01484 1e-123 glnQ E abc transporter atp-binding protein
CCEKOFMD_01486 5e-94 V VanZ like family
CCEKOFMD_01487 9.2e-43 rpsO J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CCEKOFMD_01488 9.3e-201 yhjX P Major Facilitator
CCEKOFMD_01489 1.1e-113 fnr5 K Catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
CCEKOFMD_01490 3.3e-112 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
CCEKOFMD_01491 1.7e-237 ilvA 4.3.1.19 E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CCEKOFMD_01492 1.9e-45 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
CCEKOFMD_01493 5.6e-59 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
CCEKOFMD_01494 2e-27 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
CCEKOFMD_01495 1.4e-09 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
CCEKOFMD_01496 2.3e-75 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
CCEKOFMD_01497 0.0 relA 2.7.6.5 KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CCEKOFMD_01498 1.8e-83 nrdI F Belongs to the NrdI family
CCEKOFMD_01499 2.3e-51 cpdB 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
CCEKOFMD_01500 7.7e-140 cpdB 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
CCEKOFMD_01501 9.2e-139 cpdB 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
CCEKOFMD_01502 1.4e-42 F nucleotide catabolic process
CCEKOFMD_01503 4.4e-135 rsmE 2.1.1.193 J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
CCEKOFMD_01504 3.7e-179 prmA J Ribosomal protein L11 methyltransferase
CCEKOFMD_01505 3.7e-81 mutT3 3.6.1.13, 3.6.1.55 L NUDIX domain
CCEKOFMD_01506 1.3e-84 XK27_03960 S Protein of unknown function (DUF3013)
CCEKOFMD_01507 7.6e-310 pyrG 6.3.4.2 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
CCEKOFMD_01508 4.8e-73 rpoE K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
CCEKOFMD_01509 6.4e-219 tig D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
CCEKOFMD_01510 9.3e-150 ykuT M mechanosensitive ion channel
CCEKOFMD_01511 1.6e-77 sigH K DNA-templated transcription, initiation
CCEKOFMD_01512 1.3e-82
CCEKOFMD_01513 1.5e-233 cfa 2.1.1.317, 2.1.1.79 M cyclopropane-fatty-acyl-phospholipid synthase
CCEKOFMD_01514 1.8e-56 amd 3.5.1.47 E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
CCEKOFMD_01516 1.7e-60 hmpT S membrane
CCEKOFMD_01517 6.2e-137 thiD 2.7.1.35, 2.7.1.49, 2.7.4.7 H phosphomethylpyrimidine kinase
CCEKOFMD_01518 7.7e-140 truA 5.4.99.12 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
CCEKOFMD_01519 9.1e-185 dnaJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
CCEKOFMD_01520 2.8e-308 dnaK D Heat shock 70 kDa protein
CCEKOFMD_01521 1.3e-71 grpE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CCEKOFMD_01522 5.8e-197 hrcA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
CCEKOFMD_01523 1.3e-102 acmA 3.2.1.17 NU amidase activity
CCEKOFMD_01524 1.6e-143 vanY 3.4.17.14 M D-alanyl-D-alanine carboxypeptidase
CCEKOFMD_01525 2.2e-38 ais G alpha-ribazole phosphatase activity
CCEKOFMD_01526 1.9e-242 XK27_08635 S UPF0210 protein
CCEKOFMD_01527 3.6e-39 gcvR T UPF0237 protein
CCEKOFMD_01528 3.3e-225 capA M Bacterial capsule synthesis protein
CCEKOFMD_01529 5.7e-91 tnp L Transposase
CCEKOFMD_01530 3.4e-75 isp2 S pathogenesis
CCEKOFMD_01532 4.9e-173
CCEKOFMD_01533 2.8e-39 S Helix-turn-helix domain
CCEKOFMD_01534 5.9e-222 int L Belongs to the 'phage' integrase family
CCEKOFMD_01535 2.9e-90 3.6.4.12 K Divergent AAA domain protein
CCEKOFMD_01536 5.9e-24 3.6.4.12
CCEKOFMD_01537 2.5e-183 EGP Major facilitator Superfamily
CCEKOFMD_01538 9.1e-231 spaC2 V Lanthionine synthetase C family protein
CCEKOFMD_01539 0.0 S Lantibiotic dehydratase, C terminus
CCEKOFMD_01541 1.5e-35 K sequence-specific DNA binding
CCEKOFMD_01542 9.5e-65 rpsI J Belongs to the universal ribosomal protein uS9 family
CCEKOFMD_01543 2e-79 rplM J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CCEKOFMD_01544 1.6e-182 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CCEKOFMD_01545 1.8e-31 K helix-turn-helix
CCEKOFMD_01546 3.4e-155 degV S DegV family
CCEKOFMD_01547 3.5e-91 yacP S RNA-binding protein containing a PIN domain
CCEKOFMD_01548 5.7e-135 trmH 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CCEKOFMD_01551 4.2e-68 mrnC J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CCEKOFMD_01552 1.5e-258 cysS 6.1.1.16, 6.3.1.13 J Belongs to the class-I aminoacyl-tRNA synthetase family
CCEKOFMD_01553 1.1e-112 cysE 2.3.1.30 E serine acetyltransferase
CCEKOFMD_01554 7.9e-106 S SseB protein N-terminal domain
CCEKOFMD_01555 0.0 pnp 2.7.7.8 J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
CCEKOFMD_01556 4.2e-231 dacA 3.4.16.4 M Belongs to the peptidase S11 family
CCEKOFMD_01557 1.8e-32 dacA 3.4.16.4 M Belongs to the peptidase S11 family
CCEKOFMD_01558 3.2e-151 dacA 3.4.16.4 M Belongs to the peptidase S11 family
CCEKOFMD_01559 0.0 clpC O Belongs to the ClpA ClpB family
CCEKOFMD_01560 6.2e-76 ctsR K Belongs to the CtsR family
CCEKOFMD_01561 1.1e-83 S Putative small multi-drug export protein
CCEKOFMD_01562 3e-182 tsf J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CCEKOFMD_01563 3.7e-137 rpsB J Belongs to the universal ribosomal protein uS2 family
CCEKOFMD_01566 3.2e-68 yocD 3.4.17.13 V proteins, homologs of microcin C7 resistance protein MccF
CCEKOFMD_01567 7.9e-76 yocD 3.4.17.13 V carboxypeptidase activity
CCEKOFMD_01569 6.4e-41 L transposition
CCEKOFMD_01570 6.9e-89 L Integrase core domain protein
CCEKOFMD_01571 3.5e-97 S reductase
CCEKOFMD_01572 2.6e-55 badR K DNA-binding transcription factor activity
CCEKOFMD_01573 5.5e-36 XK27_02060 S Transglycosylase associated protein
CCEKOFMD_01574 1.2e-235 pepS E COG2309 Leucyl aminopeptidase (aminopeptidase T)
CCEKOFMD_01575 0.0 polC 2.7.7.7 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CCEKOFMD_01580 1.9e-07
CCEKOFMD_01582 2.3e-66 spxA_2 1.20.4.1 P Belongs to the ArsC family
CCEKOFMD_01583 4.7e-205 recA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CCEKOFMD_01584 6.5e-232 cinA 3.5.1.42 S Belongs to the CinA family
CCEKOFMD_01585 1.9e-106 tag 3.2.2.20 L 3-methyladenine DNA glycosylase
CCEKOFMD_01586 7.8e-103 ruvA 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
CCEKOFMD_01588 0.0 mutL L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CCEKOFMD_01590 6.5e-63 KT phosphorelay signal transduction system
CCEKOFMD_01591 1.9e-80 S Protein of unknown function (DUF3021)
CCEKOFMD_01592 0.0 mutS L that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CCEKOFMD_01593 1e-57 ymcA 3.6.3.21 S Belongs to the UPF0342 family
CCEKOFMD_01594 8.2e-70 argR K Regulates arginine biosynthesis genes
CCEKOFMD_01596 1.2e-57 T Toxic component of a toxin-antitoxin (TA) module
CCEKOFMD_01599 4.2e-35 amiA E ABC transporter, substrate-binding protein, family 5
CCEKOFMD_01600 1.2e-09 L Transposase
CCEKOFMD_01601 0.0 argS 6.1.1.19 J Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
CCEKOFMD_01602 8.7e-248 purB 4.3.2.2 F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CCEKOFMD_01603 2e-140 1.1.1.169 H Ketopantoate reductase
CCEKOFMD_01604 2.2e-204 purK 6.3.4.18 F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CCEKOFMD_01605 4.9e-76 purE 5.4.99.18 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CCEKOFMD_01606 3.4e-241 purD 6.3.4.13 F Belongs to the GARS family
CCEKOFMD_01607 2.3e-161 S CHAP domain
CCEKOFMD_01608 2e-32 L Integrase core domain protein
CCEKOFMD_01609 3.5e-50 L transposition
CCEKOFMD_01610 1e-90 L transposase activity
CCEKOFMD_01611 1.5e-294 purH 2.1.2.3, 3.5.4.10 F Bifunctional purine biosynthesis protein PurH
CCEKOFMD_01612 1.4e-101 purN 2.1.2.2 F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CCEKOFMD_01613 1.8e-184 purM 6.3.3.1, 6.3.4.13 F Phosphoribosylformylglycinamidine cyclo-ligase
CCEKOFMD_01614 1.3e-276 purF 2.4.2.14 F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CCEKOFMD_01615 0.0 purL 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CCEKOFMD_01616 9.9e-129 purC 4.1.1.21, 4.3.2.2, 6.3.2.6 F Belongs to the SAICAR synthetase family
CCEKOFMD_01617 9.3e-34 acpP1 IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
CCEKOFMD_01618 9.6e-178 plsX 2.3.1.15 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
CCEKOFMD_01619 7e-144 recO L Involved in DNA repair and RecF pathway recombination
CCEKOFMD_01620 2.9e-218 araT 2.6.1.1 E Aminotransferase
CCEKOFMD_01621 1.2e-174 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CCEKOFMD_01622 1.7e-90 usp 3.5.1.28 CBM50 S CHAP domain
CCEKOFMD_01623 9.1e-87 mreD M Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CCEKOFMD_01624 5.5e-139 mreC M Involved in formation and maintenance of cell shape
CCEKOFMD_01630 5.3e-11
CCEKOFMD_01639 2.3e-23 tmp1 S Domain of unknown function (DUF4391)
CCEKOFMD_01640 0.0 L helicase superfamily c-terminal domain
CCEKOFMD_01641 8.8e-30 S Protein of unknown function DUF262
CCEKOFMD_01642 2.4e-136
CCEKOFMD_01643 8.1e-157
CCEKOFMD_01644 3.5e-169 L T/G mismatch-specific endonuclease activity
CCEKOFMD_01645 0.0 L DNA helicase
CCEKOFMD_01646 0.0 hsdR 3.1.21.3 V Subunit R is required for both nuclease and ATPase activities, but not for modification
CCEKOFMD_01647 1.6e-272 hsdM 2.1.1.72 V type I restriction-modification system
CCEKOFMD_01648 1.3e-72 3.1.21.3 V Type I restriction modification DNA specificity domain
CCEKOFMD_01649 1e-125 L Belongs to the 'phage' integrase family
CCEKOFMD_01650 3.8e-54
CCEKOFMD_01651 0.0 res 3.1.21.5 L Type III restriction
CCEKOFMD_01652 2.4e-262 mod 2.1.1.72 L PFAM DNA methylase
CCEKOFMD_01653 8.7e-46 tmp1 S Domain of unknown function (DUF4391)
CCEKOFMD_01654 1.5e-07 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
CCEKOFMD_01655 5.5e-184 jag S RNA-binding protein
CCEKOFMD_01656 1e-13 rpmH J Ribosomal protein L34
CCEKOFMD_01657 7.7e-85 L Transposase
CCEKOFMD_01658 1.7e-226 tgt 2.4.2.29 F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
CCEKOFMD_01660 1.5e-135 4.1.1.86 E Pyridoxal-dependent decarboxylase conserved domain
CCEKOFMD_01661 2.7e-34 M Psort location Cytoplasmic, score
CCEKOFMD_01663 5.4e-48 M Glycosyltransferase, group 2 family protein
CCEKOFMD_01664 3.1e-37 pdxH S Pyridoxamine 5'-phosphate oxidase
CCEKOFMD_01665 1.3e-91 steT E amino acid
CCEKOFMD_01666 2.2e-229 amd 3.5.1.47 E Peptidase family M20/M25/M40
CCEKOFMD_01667 8.4e-242 M LPXTG cell wall anchor motif
CCEKOFMD_01668 1.5e-101 3.4.22.70 M Sortase family
CCEKOFMD_01669 4.8e-51 trxA O Belongs to the thioredoxin family
CCEKOFMD_01670 2.5e-74 yccU S CoA-binding protein
CCEKOFMD_01671 4.1e-144 tatD L Hydrolase, tatd
CCEKOFMD_01672 8.4e-99 rnmV 3.1.26.8 J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CCEKOFMD_01673 1.1e-156 ksgA 2.1.1.182 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
CCEKOFMD_01675 2.6e-163 rsgA 3.1.3.100 G One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
CCEKOFMD_01676 3e-119 rpe 5.1.3.1 G Belongs to the ribulose-phosphate 3-epimerase family
CCEKOFMD_01677 3.1e-118 thiN 2.7.6.2 H thiamine pyrophosphokinase
CCEKOFMD_01678 6.9e-173 rmuC S RmuC domain protein
CCEKOFMD_01679 3.6e-179 cbf S 3'-5' exoribonuclease yhaM
CCEKOFMD_01680 1.1e-142 purR 2.4.2.7 F operon repressor
CCEKOFMD_01681 2.3e-69 rpsL J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CCEKOFMD_01682 6.7e-81 rpsG J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
CCEKOFMD_01683 0.0 fusA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CCEKOFMD_01684 9.3e-189 gap 1.2.1.12 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
CCEKOFMD_01685 2.2e-185 L Transposase
CCEKOFMD_01686 1.9e-46 L transposase activity
CCEKOFMD_01687 3.2e-42 L Transposase
CCEKOFMD_01688 2e-222 pgk 2.7.2.3, 5.3.1.1 F Belongs to the phosphoglycerate kinase family
CCEKOFMD_01689 2.7e-31 L Transposase
CCEKOFMD_01690 1.3e-87 S Fusaric acid resistance protein-like
CCEKOFMD_01691 8.5e-63 glnR K Transcriptional regulator
CCEKOFMD_01692 1.5e-263 glnA 6.3.1.2 E glutamine synthetase
CCEKOFMD_01693 2.7e-40 pscB M CHAP domain protein
CCEKOFMD_01694 0.0 rnjA S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CCEKOFMD_01695 2.5e-33 ykzG S Belongs to the UPF0356 family
CCEKOFMD_01696 5.6e-121 yeaZ 2.3.1.234 O COG1214, inactive homolog of metal-dependent proteases
CCEKOFMD_01697 4.8e-73 rimI 2.3.1.128 K This enzyme acetylates the N-terminal alanine of ribosomal protein S18
CCEKOFMD_01698 1.9e-186 tsaD 2.3.1.234 O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CCEKOFMD_01699 1.8e-114 azlC E AzlC protein
CCEKOFMD_01700 5.7e-47 azlD E branched-chain amino acid
CCEKOFMD_01701 0.0 recD2 3.1.11.5 L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
CCEKOFMD_01702 1.8e-113 lepB 3.4.21.89 U Belongs to the peptidase S26 family
CCEKOFMD_01703 4.7e-160 rnhC 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CCEKOFMD_01704 2.3e-13 zapA D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CCEKOFMD_01705 1e-93 cvpA S toxin biosynthetic process
CCEKOFMD_01706 0.0 mutS2 L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
CCEKOFMD_01707 0.0 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CCEKOFMD_01713 6.1e-229 mutY L A G-specific adenine glycosylase
CCEKOFMD_01714 9.5e-42 XK27_05745
CCEKOFMD_01715 3.9e-47 rpsF J Binds together with S18 to 16S ribosomal RNA
CCEKOFMD_01716 2.7e-91 ssb L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
CCEKOFMD_01717 9.7e-36 rpsR J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CCEKOFMD_01719 3.1e-124 XK27_01040 S Pfam PF06570
CCEKOFMD_01720 2e-169 corA P COG0598 Mg2 and Co2 transporters
CCEKOFMD_01721 0.0 uvrA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CCEKOFMD_01724 1e-58 V 'abc transporter, ATP-binding protein
CCEKOFMD_01725 8e-44 V 'abc transporter, ATP-binding protein
CCEKOFMD_01727 5e-193 pepP 3.4.11.9, 3.4.13.9 E Belongs to the peptidase M24B family
CCEKOFMD_01728 3.7e-84 comEB 3.5.4.12 F ComE operon protein 2
CCEKOFMD_01729 1.2e-97 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CCEKOFMD_01730 3.4e-62 yqhY S protein conserved in bacteria
CCEKOFMD_01731 2.1e-73 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CCEKOFMD_01732 7.5e-180 scrR K Transcriptional
CCEKOFMD_01733 5.4e-291 scrB 3.2.1.26 GH32 G invertase
CCEKOFMD_01734 0.0 scrA 2.7.1.208, 2.7.1.211 G pts system
CCEKOFMD_01735 4.1e-172 scrK 2.7.1.2, 2.7.1.4 GK Fructokinase
CCEKOFMD_01736 6.7e-189 manA 5.3.1.8 G mannose-6-phosphate isomerase
CCEKOFMD_01738 0.0 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
CCEKOFMD_01739 3.8e-198 aroF 2.5.1.54 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CCEKOFMD_01740 7.2e-197 aroF 2.5.1.54 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CCEKOFMD_01741 3.1e-62 acpS 2.7.6.3, 2.7.8.7, 5.1.1.1 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
CCEKOFMD_01742 1.8e-185 alr 5.1.1.1, 5.1.1.5 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CCEKOFMD_01743 0.0 recG 3.6.4.12 L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CCEKOFMD_01744 8.5e-173 ansA 3.5.1.1 EJ COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D
CCEKOFMD_01745 4.3e-261 XK27_03190 5.2.1.8 S hydrolases of the HAD superfamily
CCEKOFMD_01746 2.9e-18 yebC M Membrane
CCEKOFMD_01747 5.2e-81 yebC M Membrane
CCEKOFMD_01748 1.8e-65 KT response to antibiotic
CCEKOFMD_01749 7e-10 XK27_02470 K LytTr DNA-binding domain protein
CCEKOFMD_01750 9.8e-57 liaI S membrane
CCEKOFMD_01751 0.0 rexB 3.1.21.3, 3.6.4.12 L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CCEKOFMD_01752 0.0 addA 3.6.4.12 L ATP-dependent helicase nuclease subunit A
CCEKOFMD_01753 5.2e-125 S Protein of unknown function (DUF554)
CCEKOFMD_01754 8.1e-134 ecsA_2 V abc transporter atp-binding protein
CCEKOFMD_01755 2.2e-285 XK27_00765
CCEKOFMD_01756 5.7e-141 proB 2.7.2.11 E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CCEKOFMD_01757 4.5e-225 proA 1.2.1.41 E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CCEKOFMD_01758 1.1e-12 D nuclear chromosome segregation
CCEKOFMD_01759 9.7e-32 yhaI J Protein of unknown function (DUF805)
CCEKOFMD_01760 3e-128
CCEKOFMD_01761 3.9e-173 rsmH 2.1.1.199 J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
CCEKOFMD_01762 8.1e-46 ftsL D cell division protein FtsL
CCEKOFMD_01763 0.0 ftsI 3.4.16.4 M penicillin-binding protein
CCEKOFMD_01764 6.3e-185 mraY 2.7.8.13 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CCEKOFMD_01765 7.2e-221 cshB 3.6.4.13 JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
CCEKOFMD_01767 4.3e-269 yunD 3.1.3.5 F Belongs to the 5'-nucleotidase family
CCEKOFMD_01768 2.3e-72 yutD J protein conserved in bacteria
CCEKOFMD_01769 7.9e-224 rlmN 2.1.1.192 J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
CCEKOFMD_01770 1.7e-93 XK27_09885 V Glycopeptide antibiotics resistance protein
CCEKOFMD_01772 0.0 mdlA V abc transporter atp-binding protein
CCEKOFMD_01773 0.0 mdlB V abc transporter atp-binding protein
CCEKOFMD_01774 2.8e-108 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
CCEKOFMD_01775 9.3e-281 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
CCEKOFMD_01776 7.3e-237 mesE M Transport protein ComB
CCEKOFMD_01778 9.9e-239 blpH 2.7.13.3 T protein histidine kinase activity
CCEKOFMD_01779 7.4e-135 agrA KT phosphorelay signal transduction system
CCEKOFMD_01782 4.3e-25 S Bacteriocin class II with double-glycine leader peptide
CCEKOFMD_01787 6.7e-98 blpT
CCEKOFMD_01788 2.9e-28 blpT
CCEKOFMD_01789 3e-47 spiA K sequence-specific DNA binding
CCEKOFMD_01792 0.0 pepX 3.4.14.11 E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline
CCEKOFMD_01793 2.3e-164 gla U Belongs to the MIP aquaporin (TC 1.A.8) family
CCEKOFMD_01794 5e-44 V CAAX protease self-immunity
CCEKOFMD_01795 4.6e-140 cppA E CppA N-terminal
CCEKOFMD_01796 4.5e-185 ampC V COG1680 Beta-lactamase class C and other penicillin binding proteins
CCEKOFMD_01797 1.2e-117 ybbL S abc transporter atp-binding protein
CCEKOFMD_01798 1.5e-127 ybbM S transport system, permease component
CCEKOFMD_01799 2.9e-87 D nuclear chromosome segregation
CCEKOFMD_01800 1e-44 hsdS_1 3.1.21.3 V type I restriction modification DNA specificity domain
CCEKOFMD_01801 2.1e-85 yjcF S COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
CCEKOFMD_01802 1.8e-147 cah 4.2.1.1 P carbonic anhydrase
CCEKOFMD_01803 0.0 pflB 2.3.1.54 C formate acetyltransferase'
CCEKOFMD_01804 3.1e-206 dinB 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CCEKOFMD_01806 1.5e-152 yxeM ET ABC-type amino acid transport signal transduction systems, periplasmic component domain
CCEKOFMD_01807 1e-162 yxeN P ABC transporter (Permease
CCEKOFMD_01808 4.5e-132 tcyN 3.6.3.21 E abc transporter atp-binding protein
CCEKOFMD_01809 1.9e-09 S Protein of unknown function (DUF4059)
CCEKOFMD_01810 3.2e-172 trxB 1.8.1.9 C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
CCEKOFMD_01811 5.1e-93 rsmD 2.1.1.171 L Methyltransferase
CCEKOFMD_01812 2.7e-88 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CCEKOFMD_01813 2.2e-196 ylbL T Belongs to the peptidase S16 family
CCEKOFMD_01814 3.8e-184 yhcC S radical SAM protein
CCEKOFMD_01815 1.4e-98 ytqB 2.1.1.176 J (SAM)-dependent
CCEKOFMD_01817 0.0 yjcE P NhaP-type Na H and K H antiporters
CCEKOFMD_01818 1.2e-143 modF 3.6.3.21, 3.6.3.34 P abc transporter atp-binding protein
CCEKOFMD_01819 7.6e-239 hlyX S COG1253 Hemolysins and related proteins containing CBS domains
CCEKOFMD_01820 6.3e-156 pflA 1.97.1.4 C Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CCEKOFMD_01823 2.4e-75 XK27_03180 T universal stress protein
CCEKOFMD_01824 3.7e-240 alaA 2.6.1.2, 2.6.1.66 E Aminotransferase
CCEKOFMD_01825 1.2e-140 codY K DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CCEKOFMD_01826 6.8e-101 pncA Q isochorismatase
CCEKOFMD_01827 1.5e-124 hlpA M Belongs to the NlpA lipoprotein family
CCEKOFMD_01828 3.6e-96 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CCEKOFMD_01829 5.1e-77 ascB 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
CCEKOFMD_01830 1e-148 ascB 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
CCEKOFMD_01831 1.4e-47 gatC 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CCEKOFMD_01832 3.5e-269 gatA 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
CCEKOFMD_01833 7.8e-274 gatB 6.1.1.12, 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CCEKOFMD_01834 1.2e-58
CCEKOFMD_01835 3.7e-152 yicL EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
CCEKOFMD_01836 1.8e-98 yqeG S hydrolase of the HAD superfamily
CCEKOFMD_01837 1.7e-215 yqeH S in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis
CCEKOFMD_01838 3.5e-49 yhbY J RNA-binding protein
CCEKOFMD_01839 3.1e-118 nadD 2.7.7.18, 3.6.1.55 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CCEKOFMD_01840 1.4e-107 nadD 2.7.6.3, 2.7.7.18 H HD superfamily hydrolase involved in NAD metabolism
CCEKOFMD_01841 6e-58 rsfS J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
CCEKOFMD_01842 2e-140 yqeM Q Methyltransferase domain protein
CCEKOFMD_01843 6.9e-206 ylbM S Belongs to the UPF0348 family
CCEKOFMD_01844 0.0 clpL O ATP-dependent Clp protease ATP-binding subunit
CCEKOFMD_01846 7.3e-107
CCEKOFMD_01847 2.6e-55 S CD20-like family
CCEKOFMD_01848 5.6e-12
CCEKOFMD_01849 3.9e-72 hit FG Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
CCEKOFMD_01850 2.3e-133 ecsA V abc transporter atp-binding protein
CCEKOFMD_01851 2.7e-183 ecsB U ABC transporter
CCEKOFMD_01852 1.2e-151 ytmP 2.7.1.89 M Phosphotransferase
CCEKOFMD_01853 3.1e-121 trmB 2.1.1.297, 2.1.1.33 J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
CCEKOFMD_01855 3.8e-226 ytfP S Flavoprotein
CCEKOFMD_01856 0.0 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
CCEKOFMD_01857 7.4e-64 XK27_02560 S cog cog2151
CCEKOFMD_01858 1.2e-41 WQ51_02910 S Protein of unknown function, DUF536
CCEKOFMD_01859 1.4e-104 dnaQ 2.7.7.7 L DNA polymerase III
CCEKOFMD_01860 2.7e-129 K transcriptional regulator, MerR family
CCEKOFMD_01861 9.7e-28 L transposase activity
CCEKOFMD_01862 1.2e-43 yaaK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CCEKOFMD_01863 3.9e-26
CCEKOFMD_01864 0.0 ctpE P E1-E2 ATPase
CCEKOFMD_01865 5.4e-53
CCEKOFMD_01866 3.7e-42 pchB 2.5.1.19, 4.2.1.10, 4.2.99.21, 5.4.99.5 E Chorismate mutase
CCEKOFMD_01867 2.8e-257 trpE 4.1.3.27 EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CCEKOFMD_01868 8e-105 trpG 2.4.2.18, 2.6.1.85, 4.1.3.27 EH anthranilate
CCEKOFMD_01869 7.8e-180 trpD 2.4.2.18, 4.1.3.27 F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CCEKOFMD_01870 2.5e-133 trpC 4.1.1.48, 5.3.1.24 E Belongs to the TrpC family
CCEKOFMD_01871 3.3e-98 trpF 4.1.1.48, 4.2.1.160, 4.2.1.20, 5.3.1.24 E belongs to the TrpF family
CCEKOFMD_01872 1.1e-228 trpB 4.2.1.20, 5.3.1.24 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
CCEKOFMD_01873 2.1e-143 trpA 4.2.1.20 E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
CCEKOFMD_01874 2.7e-73 copY K Copper transport repressor, CopY TcrY family
CCEKOFMD_01875 0.0 copA 3.6.3.54 P P-type ATPase
CCEKOFMD_01876 4.7e-31 copZ 2.7.7.77 P Heavy metal-associated domain protein
CCEKOFMD_01877 1.7e-193 ddl 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
CCEKOFMD_01878 6e-115 papP P ABC transporter (Permease
CCEKOFMD_01879 3e-106 P ABC transporter (Permease
CCEKOFMD_01880 7.6e-135 glnQ 3.6.3.21 E abc transporter atp-binding protein
CCEKOFMD_01881 1.1e-155 cjaA ET ABC transporter substrate-binding protein
CCEKOFMD_01885 1.5e-258 murF 6.3.2.10 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
CCEKOFMD_01886 1.4e-121 ywaF S Integral membrane protein (intg_mem_TP0381)
CCEKOFMD_01887 3.1e-300 prfC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CCEKOFMD_01888 1.9e-201 yjbB G Permeases of the major facilitator superfamily
CCEKOFMD_01889 2.1e-157 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
CCEKOFMD_01890 7.8e-100 thiT S Thiamine transporter
CCEKOFMD_01891 1.9e-62 yjqA S Bacterial PH domain
CCEKOFMD_01892 2.3e-154 corA P CorA-like protein
CCEKOFMD_01893 3.2e-252 cshA 3.6.4.13 JKL DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
CCEKOFMD_01894 1e-41 yazA L endonuclease containing a URI domain
CCEKOFMD_01895 2.3e-139 yabB 2.1.1.223 L Methyltransferase
CCEKOFMD_01896 4.1e-22 nodB3 G polysaccharide deacetylase
CCEKOFMD_01897 1.7e-77 nodB3 G polysaccharide deacetylase
CCEKOFMD_01898 1.3e-142 plsC 2.3.1.51 I Acyltransferase
CCEKOFMD_01899 2.2e-96 comEA L COG1555 DNA uptake protein and related DNA-binding proteins
CCEKOFMD_01900 0.0 comEC S Competence protein ComEC
CCEKOFMD_01901 1e-232 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CCEKOFMD_01902 7e-98 XK27_07830 2.3.1.128 J Acetyltransferase GNAT Family
CCEKOFMD_01903 3.6e-230 ytoI K transcriptional regulator containing CBS domains
CCEKOFMD_01904 2.1e-165 map 3.4.11.18 E Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed
CCEKOFMD_01905 7.4e-164 rbn E Belongs to the UPF0761 family
CCEKOFMD_01906 3.7e-85 ccl S cog cog4708
CCEKOFMD_01907 0.0 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CCEKOFMD_01908 5.7e-186 yegS 2.7.1.107 I Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
CCEKOFMD_01909 1.9e-55 L Transposase
CCEKOFMD_01910 2.1e-74 S QueT transporter
CCEKOFMD_01911 8.2e-159 xth 3.1.11.2 L exodeoxyribonuclease III
CCEKOFMD_01912 6.9e-172 tehB 2.1.1.265 PQ tellurite resistance protein tehb
CCEKOFMD_01913 2.4e-43 rpsP J Belongs to the bacterial ribosomal protein bS16 family
CCEKOFMD_01914 4.1e-37 ylqC L Belongs to the UPF0109 family
CCEKOFMD_01915 1.6e-238 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
CCEKOFMD_01916 0.0 ydaO E amino acid
CCEKOFMD_01917 1e-99 folE 3.5.4.16 F gtp cyclohydrolase
CCEKOFMD_01918 7e-147 folP 2.5.1.15, 2.7.6.3 H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CCEKOFMD_01919 3.5e-298 amy 3.2.1.1 GH13 G Belongs to the glycosyl hydrolase 13 family
CCEKOFMD_01920 1.2e-61 folB 1.13.11.81, 2.5.1.15, 2.7.6.3, 4.1.2.25, 5.1.99.8 H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CCEKOFMD_01921 2.9e-87 folK 2.7.6.3, 4.1.2.25 H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CCEKOFMD_01922 7.8e-171 murB 1.3.1.98 M cell wall formation
CCEKOFMD_01923 1.2e-213 potA 3.6.3.30, 3.6.3.31 P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
CCEKOFMD_01924 3.7e-140 potB P ABC-type spermidine putrescine transport system, permease component I
CCEKOFMD_01925 3e-134 potC P ABC-type spermidine putrescine transport system, permease component II
CCEKOFMD_01926 2.3e-206 potD P spermidine putrescine ABC transporter
CCEKOFMD_01927 1.3e-19 XK27_08050 O HflC and HflK could regulate a protease
CCEKOFMD_01928 1.7e-47 XK27_08050 O stress-induced mitochondrial fusion
CCEKOFMD_01929 8.1e-72 gloA 4.4.1.5 E Lactoylglutathione lyase
CCEKOFMD_01930 3.7e-62 GK ROK family
CCEKOFMD_01931 5.5e-46 GK ROK family
CCEKOFMD_01932 1.3e-209 serC 2.6.1.52 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CCEKOFMD_01933 3.9e-104 wecD M Acetyltransferase GNAT family
CCEKOFMD_01934 7e-220 serA 1.1.1.399, 1.1.1.95 EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CCEKOFMD_01935 1.5e-52 ogt 2.1.1.63, 3.2.2.20 L methylated-DNA-[protein]-cysteine S-methyltransferase activity
CCEKOFMD_01936 5.4e-59 arsC 1.20.4.1 P Belongs to the ArsC family
CCEKOFMD_01938 2.2e-58 lrgA S Effector of murein hydrolase LrgA
CCEKOFMD_01939 2.2e-117 lrgB M effector of murein hydrolase
CCEKOFMD_01940 2.6e-109 3.1.3.18 S IA, variant 1
CCEKOFMD_01941 0.0 gyrB 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CCEKOFMD_01942 3e-304 ezrA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CCEKOFMD_01943 2e-115 serB 3.1.3.3 E phosphoserine phosphatase
CCEKOFMD_01944 0.0 cas9 L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
CCEKOFMD_01945 7.5e-163 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CCEKOFMD_01946 1.4e-53 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CCEKOFMD_01947 5.6e-110 csn2 S CRISPR-associated protein (Cas_Csn2)
CCEKOFMD_01949 8.5e-154 EG Permeases of the drug metabolite transporter (DMT) superfamily
CCEKOFMD_01951 6.6e-30 ycaO O OsmC-like protein
CCEKOFMD_01952 5.5e-65 paaI Q protein possibly involved in aromatic compounds catabolism
CCEKOFMD_01955 3.6e-134 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
CCEKOFMD_01957 1.4e-248 obg S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CCEKOFMD_01958 1.1e-16 XK27_00735
CCEKOFMD_01959 1e-136 glnQ 3.6.3.21 E abc transporter atp-binding protein
CCEKOFMD_01960 0.0 glnP P ABC-type amino acid transport signal transduction systems periplasmic component domain
CCEKOFMD_01961 2.4e-33 S CAAX amino terminal protease family protein
CCEKOFMD_01962 4.3e-82 S CAAX amino terminal protease family protein
CCEKOFMD_01964 0.0 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
CCEKOFMD_01965 2.9e-84 mutT 3.6.1.55 F Nudix family
CCEKOFMD_01966 3.7e-143 ET Belongs to the bacterial solute-binding protein 3 family
CCEKOFMD_01967 9.4e-136 ET ABC transporter
CCEKOFMD_01968 2.1e-202 arcT 2.6.1.1 E Aminotransferase
CCEKOFMD_01969 1.1e-136 gltS ET Belongs to the bacterial solute-binding protein 3 family
CCEKOFMD_01970 5.5e-20 rpsU J Belongs to the bacterial ribosomal protein bS21 family
CCEKOFMD_01971 0.0 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
CCEKOFMD_01972 1.1e-201 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
CCEKOFMD_01973 3.4e-55 yitW K metal-sulfur cluster biosynthetic enzyme
CCEKOFMD_01974 1.4e-251 M Psort location CytoplasmicMembrane, score
CCEKOFMD_01975 1.6e-171 yfdH GT2 M COG0463, glycosyltransferases involved in cell wall biogenesis
CCEKOFMD_01976 3.2e-245
CCEKOFMD_01977 1.2e-160 rfbD 1.1.1.133, 5.1.3.13 M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
CCEKOFMD_01978 7.6e-126 ycbB S Glycosyl transferase family 2
CCEKOFMD_01979 5.3e-48 XK27_09090 S Uncharacterized conserved protein (DUF2304)
CCEKOFMD_01980 2.6e-220 amrA S polysaccharide biosynthetic process
CCEKOFMD_01981 5.1e-195 tagF 2.7.8.12 M Glycosyl transferase, family 2
CCEKOFMD_01982 1.3e-226 rgpA GT4 M Domain of unknown function (DUF1972)
CCEKOFMD_01983 2.2e-179 rgpB GT2 M Glycosyltransferase, group 2 family protein
CCEKOFMD_01984 2.8e-143 rgpC GM Transport permease protein
CCEKOFMD_01985 8.7e-226 rgpD 3.6.3.38 P Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system
CCEKOFMD_01986 8.2e-196 rgpEc GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
CCEKOFMD_01987 0.0 rgpF M Rhamnan synthesis protein F
CCEKOFMD_01988 2.4e-119 radC E Belongs to the UPF0758 family
CCEKOFMD_01989 7.2e-132 puuD T peptidase C26
CCEKOFMD_01990 3.3e-118 rex K Modulates transcription in response to changes in cellular NADH NAD( ) redox state

eggNOG-mapper v2 (Database: eggNOG v5.0, Jul. 2018 release)