ORF_ID e_value Gene_name EC_number CAZy COGs Description
CMALGNEG_00001 1.3e-257 dnaA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CMALGNEG_00002 8.5e-134 parB K Belongs to the ParB family
CMALGNEG_00003 2.6e-193 htrA 3.4.21.107 O Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain'
CMALGNEG_00004 1.1e-86 rlmH 2.1.1.177 J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CMALGNEG_00005 6.2e-120 yoaK S Psort location CytoplasmicMembrane, score
CMALGNEG_00009 0.0 XK27_10405 S Bacterial membrane protein YfhO
CMALGNEG_00010 6.7e-306 ybiT S abc transporter atp-binding protein
CMALGNEG_00011 4.2e-153 yvjA S membrane
CMALGNEG_00012 3.1e-192 trpS 6.1.1.2 J Tryptophanyl-tRNA synthetase
CMALGNEG_00013 4.3e-275 guaB 1.1.1.205 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
CMALGNEG_00014 5.9e-205 recF L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CMALGNEG_00015 1.6e-45 yaaA S S4 domain protein YaaA
CMALGNEG_00016 1.7e-66 ymfF S Peptidase M16
CMALGNEG_00017 1.3e-156 ymfF S Peptidase M16
CMALGNEG_00018 1.2e-241 ymfH S Peptidase M16
CMALGNEG_00019 6.3e-138 ymfM S sequence-specific DNA binding
CMALGNEG_00020 3.1e-90 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CMALGNEG_00021 1.5e-152 ecfA1 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CMALGNEG_00022 2e-152 ecfA2 3.6.3.55 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CMALGNEG_00023 2e-138 ecfT P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CMALGNEG_00024 5.3e-85 lytE M LysM domain protein
CMALGNEG_00025 1.7e-63 isaA GH23 M Immunodominant staphylococcal antigen A
CMALGNEG_00026 0.0 S Bacterial membrane protein, YfhO
CMALGNEG_00027 8.6e-220 mnmA 2.8.1.13 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
CMALGNEG_00028 1.5e-77 F NUDIX domain
CMALGNEG_00029 0.0 gidA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
CMALGNEG_00030 0.0 yybT T signaling protein consisting of a modified GGDEF domain and a DHH domain
CMALGNEG_00031 3.9e-70 rplI J binds to the 23S rRNA
CMALGNEG_00032 1.5e-245 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
CMALGNEG_00033 8.2e-48 veg S Biofilm formation stimulator VEG
CMALGNEG_00034 9.8e-109 rpsD J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CMALGNEG_00035 2.7e-08
CMALGNEG_00036 4.8e-55 ypaA M Membrane
CMALGNEG_00037 6.4e-96 XK27_06935 K transcriptional regulator
CMALGNEG_00038 3.9e-161 XK27_06930 V domain protein
CMALGNEG_00039 1.2e-87 S Putative adhesin
CMALGNEG_00040 1.8e-19 XK27_06920 S Protein of unknown function (DUF1700)
CMALGNEG_00042 1.7e-23 K negative regulation of transcription, DNA-templated
CMALGNEG_00043 4e-19 K negative regulation of transcription, DNA-templated
CMALGNEG_00044 3.4e-13 nudL L hydrolase
CMALGNEG_00045 1.1e-11 K CsbD-like
CMALGNEG_00046 3.1e-85 M Protein conserved in bacteria
CMALGNEG_00047 1.8e-23 S Small integral membrane protein
CMALGNEG_00048 9.1e-101
CMALGNEG_00049 3.7e-27 S Membrane
CMALGNEG_00051 2.7e-95 S Hydrophobic domain protein
CMALGNEG_00052 1.5e-49 yegS 2.7.1.107 I lipid kinase activity
CMALGNEG_00055 5.1e-184 sip L Belongs to the 'phage' integrase family
CMALGNEG_00056 5.9e-20 S MerR HTH family regulatory protein
CMALGNEG_00057 2.1e-82 S Plasmid replication protein
CMALGNEG_00058 2e-20
CMALGNEG_00059 1.5e-160 D COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins
CMALGNEG_00060 1.7e-35
CMALGNEG_00061 3.2e-10 S Sigma-70, region 4
CMALGNEG_00062 0.0 V Type II restriction enzyme, methylase subunits
CMALGNEG_00063 2.4e-28
CMALGNEG_00064 6.7e-19 rpmG J Belongs to the bacterial ribosomal protein bL33 family
CMALGNEG_00065 1e-24 rpmF J Belongs to the bacterial ribosomal protein bL32 family
CMALGNEG_00066 1.4e-36 metE 2.1.1.14 E Methionine synthase
CMALGNEG_00067 5.2e-55 metE 2.1.1.14 E Methionine synthase
CMALGNEG_00068 1.4e-53 metE 2.1.1.14 E Methionine synthase
CMALGNEG_00069 1.6e-241 hisS 6.1.1.21 J histidyl-tRNA synthetase
CMALGNEG_00071 0.0 aspS 6.1.1.12 J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
CMALGNEG_00072 9.3e-167 XK27_01785 S cog cog1284
CMALGNEG_00073 1.8e-147 yaaA S Belongs to the UPF0246 family
CMALGNEG_00074 3.7e-116 nrdG 1.97.1.4 O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CMALGNEG_00075 2.6e-91 XK27_10930 K acetyltransferase
CMALGNEG_00076 7.5e-14
CMALGNEG_00077 0.0 nrdD 1.1.98.6 F Ribonucleoside-triphosphate reductase
CMALGNEG_00078 2.8e-299 ccs S the current gene model (or a revised gene model) may contain a frame shift
CMALGNEG_00079 4.2e-44 yrzB S Belongs to the UPF0473 family
CMALGNEG_00080 1.2e-70 yqgF L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CMALGNEG_00081 2.8e-44 yrzL S Belongs to the UPF0297 family
CMALGNEG_00082 8.4e-27 rpmB J Belongs to the bacterial ribosomal protein bL28 family
CMALGNEG_00083 5.2e-237 rarA L ATPase related to the helicase subunit of the Holliday junction resolvase
CMALGNEG_00085 1.7e-215 int L Belongs to the 'phage' integrase family
CMALGNEG_00086 1.9e-18 S Domain of unknown function (DUF3173)
CMALGNEG_00087 1e-155 L Replication initiation factor
CMALGNEG_00088 3.9e-287 V ABC transporter transmembrane region
CMALGNEG_00089 3e-104 C Radical SAM
CMALGNEG_00090 7.5e-109 C Radical SAM
CMALGNEG_00092 1.4e-59 Z012_04635 K sequence-specific DNA binding
CMALGNEG_00093 3.2e-56 Z012_04635 K sequence-specific DNA binding
CMALGNEG_00094 2.4e-13 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
CMALGNEG_00095 9.7e-30 S Domain of unknown function (DUF4649)
CMALGNEG_00096 7.6e-130 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
CMALGNEG_00097 1.8e-50 adk 2.7.4.3 F topology modulation protein
CMALGNEG_00098 4.1e-250 purA 6.3.4.4 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CMALGNEG_00099 1.8e-80 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CMALGNEG_00100 1.7e-35 XK27_09805 S MORN repeat protein
CMALGNEG_00101 0.0 XK27_09800 I Acyltransferase
CMALGNEG_00102 7.8e-188 ruvB 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
CMALGNEG_00103 1.3e-48 rpsJ J Involved in the binding of tRNA to the ribosomes
CMALGNEG_00104 1.1e-110 rplC J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CMALGNEG_00105 5.7e-104 rplD J Forms part of the polypeptide exit tunnel
CMALGNEG_00106 2.4e-44 rplW J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
CMALGNEG_00107 8.8e-153 rplB J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CMALGNEG_00108 4.9e-47 rpsS J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CMALGNEG_00109 7.3e-53 rplV J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CMALGNEG_00110 2.1e-117 rpsC J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CMALGNEG_00111 7.2e-71 rplP J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CMALGNEG_00112 2.7e-26 rpmC J Belongs to the universal ribosomal protein uL29 family
CMALGNEG_00113 6e-39 rpsQ J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CMALGNEG_00114 1.1e-59 rplN J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CMALGNEG_00115 1.4e-47 rplX J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CMALGNEG_00116 1.6e-94 rplE J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CMALGNEG_00117 1.5e-28 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CMALGNEG_00118 1.2e-67 rpsH J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CMALGNEG_00119 2.3e-93 rplF J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CMALGNEG_00120 1.9e-56 rplR J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CMALGNEG_00121 1.7e-79 rpsE J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CMALGNEG_00122 2.5e-23 rpmD J ribosomal protein l30
CMALGNEG_00123 4.4e-58 rplO J binds to the 23S rRNA
CMALGNEG_00124 2.1e-230 secY U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
CMALGNEG_00125 9.2e-121 adk 2.7.4.3 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
CMALGNEG_00126 2.7e-32 infA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CMALGNEG_00127 6e-15 rpmJ J Belongs to the bacterial ribosomal protein bL36 family
CMALGNEG_00128 4e-57 rpsM J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CMALGNEG_00129 9.6e-62 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CMALGNEG_00130 4.8e-171 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CMALGNEG_00131 3.3e-62 rplQ J ribosomal protein l17
CMALGNEG_00132 1.8e-111 L PFAM Integrase, catalytic core
CMALGNEG_00133 3.3e-09 L PFAM Integrase, catalytic core
CMALGNEG_00134 3.2e-12 6.3.2.2 H gamma-glutamylcysteine synthetase
CMALGNEG_00135 1.5e-65 6.3.2.2 H gamma-glutamylcysteine synthetase
CMALGNEG_00136 6.7e-110 6.3.2.2 H ergothioneine biosynthetic process
CMALGNEG_00138 9e-164 fba 4.1.2.13, 4.1.2.29 G aldolase
CMALGNEG_00139 2.2e-282 dcm 2.1.1.37 H C-5 cytosine-specific DNA methylase
CMALGNEG_00141 5.7e-217 S MvaI/BcnI restriction endonuclease family
CMALGNEG_00143 7.7e-13
CMALGNEG_00144 5e-31 S Hypothetical protein (DUF2513)
CMALGNEG_00145 6.5e-31
CMALGNEG_00146 1e-39
CMALGNEG_00151 6.4e-136 HJ the current gene model (or a revised gene model) may contain a frame shift
CMALGNEG_00152 1.2e-126 gltT C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
CMALGNEG_00153 2.5e-13 2.3.1.82 M Acetyltransferase GNAT Family
CMALGNEG_00154 3.3e-46 K Putative DNA-binding domain
CMALGNEG_00155 2e-94 L PFAM Integrase, catalytic core
CMALGNEG_00156 2e-35 L PFAM Integrase, catalytic core
CMALGNEG_00159 3.3e-95 ywlG S Belongs to the UPF0340 family
CMALGNEG_00160 1.2e-85 treR K trehalose operon
CMALGNEG_00161 5.8e-21 treR K DNA-binding transcription factor activity
CMALGNEG_00162 1.4e-54 treB 2.7.1.201 G PTS System
CMALGNEG_00163 5.9e-66 treC 3.2.1.93 GH13 G COG0366 Glycosidases
CMALGNEG_00164 1.5e-69 treC 3.2.1.93 GH13 G COG0366 Glycosidases
CMALGNEG_00165 0.0 pepO 3.4.24.71 O Peptidase family M13
CMALGNEG_00166 2.1e-52 adhE 1.1.1.1, 1.2.1.10 C Dehydrogenase
CMALGNEG_00167 1.2e-133 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
CMALGNEG_00168 7.3e-74 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
CMALGNEG_00169 4.1e-22 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
CMALGNEG_00170 6.1e-64 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
CMALGNEG_00171 1.2e-277 thrC 4.2.3.1 E Threonine synthase
CMALGNEG_00172 3.2e-226 norN V Mate efflux family protein
CMALGNEG_00173 1.8e-57 asp S cog cog1302
CMALGNEG_00174 7.6e-305 yloV S kinase related to dihydroxyacetone kinase
CMALGNEG_00175 0.0 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
CMALGNEG_00176 0.0 ilvB 2.2.1.6 EH Acetolactate synthase
CMALGNEG_00177 7.7e-77 ilvN 2.2.1.6 E Acetolactate synthase
CMALGNEG_00178 1.5e-194 ilvC 1.1.1.86 H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CMALGNEG_00179 2.1e-238 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CMALGNEG_00180 0.0 pbp1B 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
CMALGNEG_00181 0.0 rpoB 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CMALGNEG_00182 0.0 rpoC 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CMALGNEG_00183 1e-68 S cog cog4699
CMALGNEG_00184 2.1e-174 comGA NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CMALGNEG_00185 9.1e-156 cglB U protein transport across the cell outer membrane
CMALGNEG_00186 8.5e-43 comGC U Required for transformation and DNA binding
CMALGNEG_00187 1.8e-57 cglD NU Competence protein
CMALGNEG_00188 1.4e-15 NU Type II secretory pathway pseudopilin
CMALGNEG_00189 1.5e-71 comGF U Competence protein ComGF
CMALGNEG_00190 2e-12 comGF U Putative Competence protein ComGF
CMALGNEG_00191 1.9e-175 ytxK 2.1.1.72 L DNA methylase
CMALGNEG_00192 2.9e-221 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CMALGNEG_00193 2.6e-26 lanR K sequence-specific DNA binding
CMALGNEG_00194 1.1e-66 V CAAX protease self-immunity
CMALGNEG_00196 8.7e-111 S CAAX amino terminal protease family protein
CMALGNEG_00197 1.6e-249 L Transposase
CMALGNEG_00198 4.4e-130 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CMALGNEG_00199 2e-205 pepA 3.4.11.7 G COG1363 Cellulase M and related proteins
CMALGNEG_00200 4.1e-09 S Domain of unknown function (DUF4651)
CMALGNEG_00201 2.1e-54 ytpP 2.7.1.180, 5.3.4.1 CO Thioredoxin
CMALGNEG_00202 7.9e-114 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
CMALGNEG_00203 2.6e-68 yeeE S Sulphur transport
CMALGNEG_00204 2e-109 yeeE S Sulphur transport
CMALGNEG_00205 1.9e-36 yeeD O sulfur carrier activity
CMALGNEG_00206 5.1e-66 ssb_2 L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
CMALGNEG_00207 1e-90 tadA 3.5.4.1, 3.5.4.33 FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
CMALGNEG_00210 4.1e-158 rrmA 2.1.1.187 Q methyltransferase
CMALGNEG_00211 1.5e-64 S phosphatase activity
CMALGNEG_00212 1.9e-46 S glycolate biosynthetic process
CMALGNEG_00213 8.1e-59 dapD 2.3.1.117, 2.3.1.89 E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
CMALGNEG_00214 1.3e-220 hipO 3.5.1.47 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
CMALGNEG_00215 8.5e-93 ygfA 6.3.3.2 H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CMALGNEG_00216 7.5e-118 gluP 3.4.21.105 O membrane protein (homolog of Drosophila rhomboid)
CMALGNEG_00217 1.6e-168 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
CMALGNEG_00218 4.4e-186 gpsA 1.1.1.94 I Glycerol-3-phosphate dehydrogenase
CMALGNEG_00219 1.3e-83 XK27_08585 S Psort location CytoplasmicMembrane, score
CMALGNEG_00220 2.5e-116 fnt P Formate nitrite transporter
CMALGNEG_00221 1.5e-220 XK27_09615 C reductase
CMALGNEG_00222 6.2e-76 XK27_09620 S reductase
CMALGNEG_00223 4.7e-20 XK27_09620 S FMN reductase (NADPH) activity
CMALGNEG_00224 1.1e-80 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
CMALGNEG_00225 1.8e-226 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CMALGNEG_00226 6.2e-12 WQ51_05710 S Mitochondrial biogenesis AIM24
CMALGNEG_00227 7.3e-59 WQ51_05710 S Mitochondrial biogenesis AIM24
CMALGNEG_00228 2e-88 cah 4.2.1.1 P Reversible hydration of carbon dioxide
CMALGNEG_00229 3.9e-122 L Transposase
CMALGNEG_00230 1.2e-165 L integrase core domain
CMALGNEG_00231 9.2e-51 S Protein of unknown function (DUF3397)
CMALGNEG_00232 3.7e-70 rplK J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CMALGNEG_00233 4.8e-120 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
CMALGNEG_00234 7.3e-69 amiA E transmembrane transport
CMALGNEG_00235 6.7e-81 amiA E transmembrane transport
CMALGNEG_00236 2.1e-282 gltX 6.1.1.17, 6.1.1.24 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CMALGNEG_00237 2e-230 argG 6.3.4.5 E Belongs to the argininosuccinate synthase family. Type 1 subfamily
CMALGNEG_00238 4.1e-264 argH 4.3.2.1 E Argininosuccinate lyase
CMALGNEG_00239 5.9e-55 rnpA 3.1.26.5 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
CMALGNEG_00240 7.5e-141 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
CMALGNEG_00241 2e-186 jag S RNA-binding protein
CMALGNEG_00242 1e-13 rpmH J Ribosomal protein L34
CMALGNEG_00243 1.1e-83 L Transposase
CMALGNEG_00244 6.3e-226 tgt 2.4.2.29 F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
CMALGNEG_00247 2.2e-54 bta 1.8.1.8 CO cell redox homeostasis
CMALGNEG_00248 2e-09 L thioesterase
CMALGNEG_00249 1.9e-141 S Macro domain protein
CMALGNEG_00250 1.1e-50 trxA O Belongs to the thioredoxin family
CMALGNEG_00251 1.6e-143 tatD L Hydrolase, tatd
CMALGNEG_00252 1.1e-98 rnmV 3.1.26.8 J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CMALGNEG_00253 6.2e-157 ksgA 2.1.1.182 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
CMALGNEG_00255 4.1e-161 rsgA 3.1.3.100 G One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
CMALGNEG_00256 3e-119 rpe 5.1.3.1 G Belongs to the ribulose-phosphate 3-epimerase family
CMALGNEG_00257 2.4e-118 thiN 2.7.6.2 H thiamine pyrophosphokinase
CMALGNEG_00258 6.9e-173 rmuC S RmuC domain protein
CMALGNEG_00259 1.2e-177 cbf S 3'-5' exoribonuclease yhaM
CMALGNEG_00260 5.3e-142 purR 2.4.2.7 F operon repressor
CMALGNEG_00261 2.3e-69 rpsL J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CMALGNEG_00262 6.7e-81 rpsG J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
CMALGNEG_00263 0.0 fusA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CMALGNEG_00264 1.8e-187 gap 1.2.1.12 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
CMALGNEG_00265 2.9e-87 L Integrase core domain protein
CMALGNEG_00266 1.1e-53 L transposition
CMALGNEG_00267 5e-17 L Transposase
CMALGNEG_00268 5.7e-43 L transposase activity
CMALGNEG_00269 2e-222 pgk 2.7.2.3, 5.3.1.1 F Belongs to the phosphoglycerate kinase family
CMALGNEG_00270 3.1e-30
CMALGNEG_00271 1.5e-12
CMALGNEG_00272 1.3e-87 S Fusaric acid resistance protein-like
CMALGNEG_00273 8.5e-63 glnR K Transcriptional regulator
CMALGNEG_00274 1.5e-263 glnA 6.3.1.2 E glutamine synthetase
CMALGNEG_00275 2.7e-40 pscB M CHAP domain protein
CMALGNEG_00276 0.0 rnjA S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CMALGNEG_00277 2.5e-33 ykzG S Belongs to the UPF0356 family
CMALGNEG_00278 5.6e-121 yeaZ 2.3.1.234 O COG1214, inactive homolog of metal-dependent proteases
CMALGNEG_00279 1.3e-73 rimI 2.3.1.128 K This enzyme acetylates the N-terminal alanine of ribosomal protein S18
CMALGNEG_00280 1.9e-186 tsaD 2.3.1.234 O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CMALGNEG_00281 1.8e-114 azlC E AzlC protein
CMALGNEG_00282 8.8e-48 azlD E branched-chain amino acid
CMALGNEG_00283 0.0 recD2 3.1.11.5 L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
CMALGNEG_00284 1.3e-113 lepB 3.4.21.89 U Belongs to the peptidase S26 family
CMALGNEG_00285 4.7e-160 rnhC 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CMALGNEG_00286 2.3e-13 zapA D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CMALGNEG_00287 1e-93 cvpA S toxin biosynthetic process
CMALGNEG_00288 0.0 mutS2 L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
CMALGNEG_00289 0.0 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CMALGNEG_00294 2.5e-230 mutY L A G-specific adenine glycosylase
CMALGNEG_00295 3.6e-41 XK27_05745
CMALGNEG_00296 3.9e-47 rpsF J Binds together with S18 to 16S ribosomal RNA
CMALGNEG_00297 2.7e-91 ssb L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
CMALGNEG_00298 9.7e-36 rpsR J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CMALGNEG_00300 3.1e-124 XK27_01040 S Pfam PF06570
CMALGNEG_00301 2e-169 corA P COG0598 Mg2 and Co2 transporters
CMALGNEG_00302 0.0 uvrA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CMALGNEG_00305 1.1e-21 V 'abc transporter, ATP-binding protein
CMALGNEG_00306 7.7e-11 V 'abc transporter, ATP-binding protein
CMALGNEG_00309 7.2e-192 pepP 3.4.11.9, 3.4.13.9 E Belongs to the peptidase M24B family
CMALGNEG_00310 1.1e-83 comEB 3.5.4.12 F ComE operon protein 2
CMALGNEG_00311 9.3e-98 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CMALGNEG_00312 3.4e-62 yqhY S protein conserved in bacteria
CMALGNEG_00313 2.1e-73 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CMALGNEG_00314 1.7e-179 scrR K Transcriptional
CMALGNEG_00315 4.1e-291 scrB 3.2.1.26 GH32 G invertase
CMALGNEG_00316 0.0 scrA 2.7.1.211 G pts system
CMALGNEG_00317 4.1e-172 scrK 2.7.1.2, 2.7.1.4 GK Fructokinase
CMALGNEG_00318 3e-189 manA 5.3.1.8 G mannose-6-phosphate isomerase
CMALGNEG_00320 0.0 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
CMALGNEG_00321 2.9e-198 aroF 2.5.1.54 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CMALGNEG_00322 1.1e-197 aroF 2.5.1.54 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CMALGNEG_00323 4.1e-62 acpS 2.7.6.3, 2.7.8.7, 5.1.1.1 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
CMALGNEG_00324 1.5e-184 alr 5.1.1.1, 5.1.1.5 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CMALGNEG_00325 0.0 recG 3.6.4.12 L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CMALGNEG_00326 1.5e-172 ansA 3.5.1.1 EJ COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D
CMALGNEG_00327 2.5e-261 XK27_03190 5.2.1.8 S hydrolases of the HAD superfamily
CMALGNEG_00328 2.9e-18 yebC M Membrane
CMALGNEG_00329 1.6e-79 yebC M Membrane
CMALGNEG_00330 3.5e-17 KT response to antibiotic
CMALGNEG_00331 8.5e-68 KT response to antibiotic
CMALGNEG_00332 5.4e-10 XK27_02470 K LytTr DNA-binding domain protein
CMALGNEG_00333 3.4e-57 liaI S membrane
CMALGNEG_00334 0.0 rexB 3.1.21.3, 3.6.4.12 L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CMALGNEG_00335 0.0 addA 3.6.4.12 L ATP-dependent helicase nuclease subunit A
CMALGNEG_00336 9.3e-122 S Protein of unknown function (DUF554)
CMALGNEG_00337 2.1e-129 ecsA_2 V abc transporter atp-binding protein
CMALGNEG_00338 9.2e-284 XK27_00765
CMALGNEG_00339 4.4e-141 proB 2.7.2.11 E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CMALGNEG_00340 6.9e-210 proA 1.2.1.41 E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CMALGNEG_00341 4.5e-18 D nuclear chromosome segregation
CMALGNEG_00342 2.8e-21 yhaI J Protein of unknown function (DUF805)
CMALGNEG_00343 3.4e-58
CMALGNEG_00344 2.2e-85
CMALGNEG_00345 3.9e-173 rsmH 2.1.1.199 J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
CMALGNEG_00346 8.1e-46 ftsL D cell division protein FtsL
CMALGNEG_00347 0.0 ftsI 3.4.16.4 M penicillin-binding protein
CMALGNEG_00348 6.3e-185 mraY 2.7.8.13 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CMALGNEG_00349 3.2e-221 cshB 3.6.4.13 JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
CMALGNEG_00350 1.1e-250 L Transposase
CMALGNEG_00352 4.8e-268 yunD 3.1.3.5 F Belongs to the 5'-nucleotidase family
CMALGNEG_00353 2.4e-66 yutD J protein conserved in bacteria
CMALGNEG_00354 7.9e-224 rlmN 2.1.1.192 J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
CMALGNEG_00355 1.7e-93 XK27_09885 V Glycopeptide antibiotics resistance protein
CMALGNEG_00357 0.0 mdlA V abc transporter atp-binding protein
CMALGNEG_00358 0.0 mdlB V abc transporter atp-binding protein
CMALGNEG_00359 0.0 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
CMALGNEG_00360 4e-235 mesE M Transport protein ComB
CMALGNEG_00362 1.4e-237 blpH 2.7.13.3 T protein histidine kinase activity
CMALGNEG_00363 4.4e-132 agrA KT phosphorelay signal transduction system
CMALGNEG_00366 4.3e-25 S Bacteriocin class II with double-glycine leader peptide
CMALGNEG_00371 1.2e-165 L integrase core domain
CMALGNEG_00372 3.9e-122 L Transposase
CMALGNEG_00373 6.7e-98 blpT
CMALGNEG_00374 2.9e-28 blpT
CMALGNEG_00375 3e-47 spiA K sequence-specific DNA binding
CMALGNEG_00378 0.0 pepX 3.4.14.11 E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline
CMALGNEG_00379 2.3e-164 gla U Belongs to the MIP aquaporin (TC 1.A.8) family
CMALGNEG_00380 5e-44 V CAAX protease self-immunity
CMALGNEG_00381 4.6e-140 cppA E CppA N-terminal
CMALGNEG_00382 4.5e-185 ampC V COG1680 Beta-lactamase class C and other penicillin binding proteins
CMALGNEG_00383 4.4e-115 ybbL S abc transporter atp-binding protein
CMALGNEG_00384 1.5e-127 ybbM S transport system, permease component
CMALGNEG_00385 1.4e-33 D nuclear chromosome segregation
CMALGNEG_00386 7.2e-46 hsdS_1 3.1.21.3 V type I restriction modification DNA specificity domain
CMALGNEG_00387 2.1e-85 yjcF S COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
CMALGNEG_00388 1.8e-147 cah 4.2.1.1 P carbonic anhydrase
CMALGNEG_00389 0.0 pflB 2.3.1.54 C formate acetyltransferase'
CMALGNEG_00390 1.3e-204 dinB 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CMALGNEG_00392 8.8e-153 yxeM ET ABC-type amino acid transport signal transduction systems, periplasmic component domain
CMALGNEG_00393 1.4e-159 yxeN P ABC transporter (Permease
CMALGNEG_00394 1.3e-131 tcyN 3.6.3.21 E abc transporter atp-binding protein
CMALGNEG_00395 6.1e-08 S Protein of unknown function (DUF4059)
CMALGNEG_00396 1.9e-172 trxB 1.8.1.9 C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
CMALGNEG_00397 5.1e-93 rsmD 2.1.1.171 L Methyltransferase
CMALGNEG_00398 2e-88 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CMALGNEG_00399 8.4e-196 ylbL T Belongs to the peptidase S16 family
CMALGNEG_00400 1.3e-184 yhcC S radical SAM protein
CMALGNEG_00401 1.4e-98 ytqB 2.1.1.176 J (SAM)-dependent
CMALGNEG_00403 0.0 yjcE P NhaP-type Na H and K H antiporters
CMALGNEG_00404 2.4e-144 modF 3.6.3.21, 3.6.3.34 P abc transporter atp-binding protein
CMALGNEG_00405 2e-239 hlyX S COG1253 Hemolysins and related proteins containing CBS domains
CMALGNEG_00406 2e-157 pflA 1.97.1.4 C Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CMALGNEG_00409 2.4e-75 XK27_03180 T universal stress protein
CMALGNEG_00410 6.2e-240 alaA 2.6.1.2, 2.6.1.66 E Aminotransferase
CMALGNEG_00411 1.2e-140 codY K DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CMALGNEG_00412 3.4e-100 pncA Q isochorismatase
CMALGNEG_00413 2.1e-154 hlpA M Belongs to the NlpA lipoprotein family
CMALGNEG_00414 3.6e-96 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CMALGNEG_00415 5.1e-77 ascB 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
CMALGNEG_00416 1e-148 ascB 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
CMALGNEG_00417 6.3e-31 M lipopolysaccharide 3-alpha-galactosyltransferase activity
CMALGNEG_00418 9.8e-25 2.4.1.52 GT4 M transferase activity, transferring glycosyl groups
CMALGNEG_00419 1.4e-47 gatC 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CMALGNEG_00420 1.6e-269 gatA 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
CMALGNEG_00421 8.7e-273 gatB 6.1.1.12, 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CMALGNEG_00422 4e-59
CMALGNEG_00423 6.7e-154 yicL EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
CMALGNEG_00424 1.8e-98 yqeG S hydrolase of the HAD superfamily
CMALGNEG_00425 2.4e-214 yqeH S in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis
CMALGNEG_00426 3.5e-49 yhbY J RNA-binding protein
CMALGNEG_00427 3.1e-118 nadD 2.7.7.18, 3.6.1.55 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CMALGNEG_00428 1.4e-107 nadD 2.7.6.3, 2.7.7.18 H HD superfamily hydrolase involved in NAD metabolism
CMALGNEG_00429 6e-58 rsfS J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
CMALGNEG_00430 2e-140 yqeM Q Methyltransferase domain protein
CMALGNEG_00431 1.2e-202 ylbM S Belongs to the UPF0348 family
CMALGNEG_00432 0.0 clpL O ATP-dependent Clp protease ATP-binding subunit
CMALGNEG_00433 6.5e-55
CMALGNEG_00434 4.8e-11
CMALGNEG_00435 5e-72 hit FG Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
CMALGNEG_00436 2.3e-133 ecsA V abc transporter atp-binding protein
CMALGNEG_00437 1.6e-183 ecsB U ABC transporter
CMALGNEG_00438 1.2e-151 ytmP 2.7.1.89 M Phosphotransferase
CMALGNEG_00439 3.1e-121 trmB 2.1.1.297, 2.1.1.33 J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
CMALGNEG_00441 7.7e-227 ytfP S Flavoprotein
CMALGNEG_00442 0.0 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
CMALGNEG_00443 7.4e-64 XK27_02560 S cog cog2151
CMALGNEG_00444 9.1e-42 WQ51_02910 S Protein of unknown function, DUF536
CMALGNEG_00445 1.3e-105 dnaQ 2.7.7.7 L DNA polymerase III
CMALGNEG_00446 5.3e-119 K transcriptional regulator, MerR family
CMALGNEG_00447 5.1e-47 L transposase activity
CMALGNEG_00448 1.2e-43 yaaK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CMALGNEG_00449 6.1e-27
CMALGNEG_00450 0.0 ctpE P E1-E2 ATPase
CMALGNEG_00451 1.6e-55
CMALGNEG_00452 1.5e-255 trpE 4.1.3.27 EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CMALGNEG_00453 2.3e-104 trpG 2.4.2.18, 2.6.1.85, 4.1.3.27 EH anthranilate
CMALGNEG_00454 1.5e-178 trpD 2.4.2.18, 4.1.3.27 F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CMALGNEG_00455 1.9e-133 trpC 4.1.1.48, 5.3.1.24 E Belongs to the TrpC family
CMALGNEG_00456 3e-99 trpF 4.1.1.48, 4.2.1.160, 4.2.1.20, 5.3.1.24 E belongs to the TrpF family
CMALGNEG_00457 2.1e-227 trpB 4.2.1.20, 5.3.1.24 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
CMALGNEG_00458 2.1e-143 trpA 4.2.1.20 E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
CMALGNEG_00459 2.7e-73 copY K Copper transport repressor, CopY TcrY family
CMALGNEG_00460 0.0 copA 3.6.3.54 P P-type ATPase
CMALGNEG_00461 4.7e-31 copZ 2.7.7.77 P Heavy metal-associated domain protein
CMALGNEG_00462 1.7e-193 ddl 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
CMALGNEG_00463 6e-115 papP P ABC transporter (Permease
CMALGNEG_00464 3e-106 P ABC transporter (Permease
CMALGNEG_00465 1.7e-134 glnQ 3.6.3.21 E abc transporter atp-binding protein
CMALGNEG_00466 1.1e-155 cjaA ET ABC transporter substrate-binding protein
CMALGNEG_00470 1.5e-258 murF 6.3.2.10 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
CMALGNEG_00471 7.9e-120 ywaF S Integral membrane protein (intg_mem_TP0381)
CMALGNEG_00472 3.1e-300 prfC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CMALGNEG_00473 1.6e-200 yjbB G Permeases of the major facilitator superfamily
CMALGNEG_00474 2.1e-157 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
CMALGNEG_00475 7.8e-100 thiT S Thiamine transporter
CMALGNEG_00476 1.9e-62 yjqA S Bacterial PH domain
CMALGNEG_00477 2.3e-154 corA P CorA-like protein
CMALGNEG_00478 3.2e-252 cshA 3.6.4.13 JKL DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
CMALGNEG_00480 1e-41 yazA L endonuclease containing a URI domain
CMALGNEG_00481 2.3e-139 yabB 2.1.1.223 L Methyltransferase
CMALGNEG_00482 1.7e-77 nodB3 G polysaccharide deacetylase
CMALGNEG_00483 8.3e-142 plsC 2.3.1.51 I Acyltransferase
CMALGNEG_00484 2.2e-96 comEA L COG1555 DNA uptake protein and related DNA-binding proteins
CMALGNEG_00485 0.0 comEC S Competence protein ComEC
CMALGNEG_00486 1e-232 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CMALGNEG_00487 2.4e-98 XK27_07830 2.3.1.128 J Acetyltransferase GNAT Family
CMALGNEG_00488 3.3e-231 ytoI K transcriptional regulator containing CBS domains
CMALGNEG_00489 1.5e-166 map 3.4.11.18 E Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed
CMALGNEG_00490 7.4e-164 rbn E Belongs to the UPF0761 family
CMALGNEG_00491 3.7e-85 ccl S cog cog4708
CMALGNEG_00492 0.0 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CMALGNEG_00493 5.7e-186 yegS 2.7.1.107 I Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
CMALGNEG_00494 1.9e-55 L Transposase
CMALGNEG_00495 2.1e-74 S QueT transporter
CMALGNEG_00496 8.2e-159 xth 3.1.11.2 L exodeoxyribonuclease III
CMALGNEG_00497 6.9e-172 tehB 2.1.1.265 PQ tellurite resistance protein tehb
CMALGNEG_00498 2.4e-43 rpsP J Belongs to the bacterial ribosomal protein bS16 family
CMALGNEG_00499 4.1e-37 ylqC L Belongs to the UPF0109 family
CMALGNEG_00500 1.1e-239 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
CMALGNEG_00501 0.0 ydaO E amino acid
CMALGNEG_00502 1e-99 folE 3.5.4.16 F gtp cyclohydrolase
CMALGNEG_00503 1.2e-146 folP 2.5.1.15, 2.7.6.3 H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CMALGNEG_00504 1.2e-298 amy 3.2.1.1 GH13 G Belongs to the glycosyl hydrolase 13 family
CMALGNEG_00505 1.2e-61 folB 1.13.11.81, 2.5.1.15, 2.7.6.3, 4.1.2.25, 5.1.99.8 H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CMALGNEG_00506 2.9e-87 folK 2.7.6.3, 4.1.2.25 H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CMALGNEG_00507 7.8e-171 murB 1.3.1.98 M cell wall formation
CMALGNEG_00508 6.2e-213 potA 3.6.3.30, 3.6.3.31 P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
CMALGNEG_00509 3.7e-140 potB P ABC-type spermidine putrescine transport system, permease component I
CMALGNEG_00510 3e-134 potC P ABC-type spermidine putrescine transport system, permease component II
CMALGNEG_00511 2.3e-206 potD P spermidine putrescine ABC transporter
CMALGNEG_00512 1.3e-19 XK27_08050 O HflC and HflK could regulate a protease
CMALGNEG_00513 1.7e-47 XK27_08050 O stress-induced mitochondrial fusion
CMALGNEG_00514 8.1e-72 gloA 4.4.1.5 E Lactoylglutathione lyase
CMALGNEG_00515 2.6e-95 GK ROK family
CMALGNEG_00516 1.3e-209 serC 2.6.1.52 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CMALGNEG_00517 3.9e-104 wecD M Acetyltransferase GNAT family
CMALGNEG_00518 7e-220 serA 1.1.1.399, 1.1.1.95 EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CMALGNEG_00519 1.5e-52 ogt 2.1.1.63, 3.2.2.20 L methylated-DNA-[protein]-cysteine S-methyltransferase activity
CMALGNEG_00520 5.4e-59 arsC 1.20.4.1 P Belongs to the ArsC family
CMALGNEG_00522 2.2e-58 lrgA S Effector of murein hydrolase LrgA
CMALGNEG_00523 2.2e-117 lrgB M effector of murein hydrolase
CMALGNEG_00524 2.6e-109 3.1.3.18 S IA, variant 1
CMALGNEG_00525 0.0 gyrB 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CMALGNEG_00526 2.8e-302 ezrA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CMALGNEG_00527 7.4e-115 serB 3.1.3.3 E phosphoserine phosphatase
CMALGNEG_00528 0.0 cas9 L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
CMALGNEG_00529 1.5e-163 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CMALGNEG_00530 2.6e-55 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CMALGNEG_00531 1.6e-112 csn2 S CRISPR-associated protein (Cas_Csn2)
CMALGNEG_00533 1.9e-153 EG Permeases of the drug metabolite transporter (DMT) superfamily
CMALGNEG_00534 6.6e-30 ycaO O OsmC-like protein
CMALGNEG_00535 5.5e-65 paaI Q protein possibly involved in aromatic compounds catabolism
CMALGNEG_00538 3.6e-134 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
CMALGNEG_00540 1.4e-248 obg S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CMALGNEG_00541 2.4e-16 XK27_00735
CMALGNEG_00542 1e-136 glnQ 3.6.3.21 E abc transporter atp-binding protein
CMALGNEG_00543 0.0 glnP P ABC-type amino acid transport signal transduction systems periplasmic component domain
CMALGNEG_00544 2.6e-32 S CAAX amino terminal protease family protein
CMALGNEG_00545 1.2e-55 V CAAX protease self-immunity
CMALGNEG_00547 0.0 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
CMALGNEG_00548 2.9e-84 mutT 3.6.1.55 F Nudix family
CMALGNEG_00549 3.7e-143 ET Belongs to the bacterial solute-binding protein 3 family
CMALGNEG_00550 7.2e-136 ET ABC transporter
CMALGNEG_00551 3.4e-200 arcT 2.6.1.1 E Aminotransferase
CMALGNEG_00552 7.9e-135 gltS ET Belongs to the bacterial solute-binding protein 3 family
CMALGNEG_00553 1.2e-19 rpsU J Belongs to the bacterial ribosomal protein bS21 family
CMALGNEG_00554 1.1e-46 mscL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
CMALGNEG_00555 0.0 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
CMALGNEG_00556 8e-202 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
CMALGNEG_00557 3.4e-55 yitW K metal-sulfur cluster biosynthetic enzyme
CMALGNEG_00558 5.4e-251 M Psort location CytoplasmicMembrane, score
CMALGNEG_00559 1.6e-171 yfdH GT2 M COG0463, glycosyltransferases involved in cell wall biogenesis
CMALGNEG_00560 1.2e-231
CMALGNEG_00561 1.2e-160 rfbD 1.1.1.133, 5.1.3.13 M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
CMALGNEG_00562 7.6e-126 ycbB S Glycosyl transferase family 2
CMALGNEG_00563 5.3e-48 XK27_09090 S Uncharacterized conserved protein (DUF2304)
CMALGNEG_00564 2.6e-220 amrA S polysaccharide biosynthetic process
CMALGNEG_00565 5.1e-195 tagF 2.7.8.12 M Glycosyl transferase, family 2
CMALGNEG_00566 1.3e-226 rgpA GT4 M Domain of unknown function (DUF1972)
CMALGNEG_00567 2.2e-179 rgpB GT2 M Glycosyltransferase, group 2 family protein
CMALGNEG_00568 1.1e-142 rgpC GM Transport permease protein
CMALGNEG_00569 8.7e-226 rgpD 3.6.3.38 P Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system
CMALGNEG_00570 8.2e-196 rgpEc GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
CMALGNEG_00571 0.0 rgpF M Rhamnan synthesis protein F
CMALGNEG_00572 6.2e-120 radC E Belongs to the UPF0758 family
CMALGNEG_00573 1.6e-131 puuD T peptidase C26
CMALGNEG_00574 5.7e-118 rex K Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CMALGNEG_00575 9e-59 XK27_04120 S Putative amino acid metabolism
CMALGNEG_00576 3.2e-206 iscS 2.8.1.7 E Cysteine desulfurase
CMALGNEG_00577 2.1e-177 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CMALGNEG_00578 5.8e-103 yjbK S Adenylate cyclase
CMALGNEG_00579 1.5e-121 yjbM 2.7.6.5 S Gtp pyrophosphokinase
CMALGNEG_00580 1.5e-152 nadK 2.7.1.23 H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CMALGNEG_00581 9.8e-174 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 J Responsible for synthesis of pseudouridine from uracil
CMALGNEG_00582 1.4e-181 pta 2.3.1.8, 3.6.3.21 C phosphate acetyltransferase
CMALGNEG_00583 3.7e-38 L transposase activity
CMALGNEG_00584 1.4e-38 L transposase activity
CMALGNEG_00585 9.3e-29 L transposition
CMALGNEG_00586 4e-110 L PFAM Integrase catalytic region
CMALGNEG_00587 6.7e-218 oxlT P COG0477 Permeases of the major facilitator superfamily
CMALGNEG_00588 2e-21 tatD L hydrolase, TatD family'
CMALGNEG_00589 5.5e-23 oppF P Belongs to the ABC transporter superfamily
CMALGNEG_00590 1.2e-24 oppF P Belongs to the ABC transporter superfamily
CMALGNEG_00591 4.1e-158 L COG2801 Transposase and inactivated derivatives
CMALGNEG_00592 8.1e-45 L Transposase
CMALGNEG_00593 0.0 amiA E ABC transporter, substrate-binding protein, family 5
CMALGNEG_00594 1.1e-270 amiC P ABC transporter (Permease
CMALGNEG_00595 2.4e-167 amiD P ABC transporter (Permease
CMALGNEG_00596 2.2e-204 oppD P Belongs to the ABC transporter superfamily
CMALGNEG_00597 4.3e-172 oppF P Belongs to the ABC transporter superfamily
CMALGNEG_00598 9e-131 V ATPase activity
CMALGNEG_00599 9.8e-121 skfE V abc transporter atp-binding protein
CMALGNEG_00600 8.6e-63 yvoA_1 K Transcriptional
CMALGNEG_00601 5.3e-147 supH S overlaps another CDS with the same product name
CMALGNEG_00602 1.8e-150 XK27_02985 S overlaps another CDS with the same product name
CMALGNEG_00603 9.7e-213 ftsY U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
CMALGNEG_00604 9.8e-112 gmk 2.7.4.8 F Essential for recycling GMP and indirectly, cGMP
CMALGNEG_00605 2.7e-46 rpoZ 2.7.7.6 K DNA-directed 5'-3' RNA polymerase activity
CMALGNEG_00606 0.0 priA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CMALGNEG_00607 1e-173 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CMALGNEG_00608 1.7e-246 sun 2.1.1.176 J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CMALGNEG_00609 9e-133 stp 3.1.3.16 T phosphatase
CMALGNEG_00610 1.7e-305 prkC 2.7.11.1 KLT serine threonine protein kinase
CMALGNEG_00611 9.1e-119 yvqF KT membrane
CMALGNEG_00612 1.9e-173 vraS 2.7.13.3 T Histidine kinase
CMALGNEG_00613 8.2e-114 vraR K Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
CMALGNEG_00616 5.8e-94 rimM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CMALGNEG_00617 1.9e-135 trmD 2.1.1.228, 4.6.1.12 J Belongs to the RNA methyltransferase TrmD family
CMALGNEG_00618 8.6e-187 trxB1 1.18.1.2, 1.19.1.1 C Ferredoxin--NADP reductase
CMALGNEG_00619 0.0 ftsK D Belongs to the FtsK SpoIIIE SftA family
CMALGNEG_00620 1.7e-120 pulA 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
CMALGNEG_00621 1.8e-33 pulA 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
CMALGNEG_00622 7e-150 pulA 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
CMALGNEG_00623 6.4e-62 L Transposase
CMALGNEG_00624 0.0 gshF 6.3.2.2, 6.3.2.29, 6.3.2.30, 6.3.2.4 H Belongs to the glutamate--cysteine ligase type 1 family
CMALGNEG_00625 4.3e-40 V abc transporter atp-binding protein
CMALGNEG_00626 2.5e-101 V abc transporter atp-binding protein
CMALGNEG_00627 5.1e-17 rtxA M M26 IgA1-specific Metallo-endopeptidase C-terminal region
CMALGNEG_00628 3.5e-228 zmpB M M26 IgA1-specific Metallo-endopeptidase C-terminal region
CMALGNEG_00629 1.2e-25 L transposition
CMALGNEG_00630 2.7e-08 L Integrase core domain protein
CMALGNEG_00631 2.3e-184 galR K Transcriptional regulator
CMALGNEG_00632 3.7e-221 galK 2.7.1.6 G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CMALGNEG_00633 1.3e-287 galT 2.7.7.12 G UDPglucose--hexose-1-phosphate uridylyltransferase
CMALGNEG_00634 1.1e-194 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
CMALGNEG_00635 2.4e-200 galM 5.1.3.3 G Catalyzes the interconversion of alpha and beta anomers of maltose
CMALGNEG_00636 0.0 lacS G transporter
CMALGNEG_00637 0.0 lacL 3.2.1.23 G -beta-galactosidase
CMALGNEG_00638 1.3e-229 sbcD L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
CMALGNEG_00639 0.0 sbcC L ATPase involved in DNA repair
CMALGNEG_00640 1.4e-84
CMALGNEG_00642 1.8e-87 L transposase activity
CMALGNEG_00643 1.4e-150 L Integrase core domain protein
CMALGNEG_00644 6.5e-159 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
CMALGNEG_00646 5.5e-258 I radical SAM domain protein
CMALGNEG_00647 1.2e-176 EGP Major Facilitator Superfamily
CMALGNEG_00648 3.9e-110 C Fe-S oxidoreductases
CMALGNEG_00650 1.1e-151 V MatE
CMALGNEG_00651 1.1e-116 devA 3.6.3.25 V abc transporter atp-binding protein
CMALGNEG_00652 5e-161 hrtB V MacB-like periplasmic core domain
CMALGNEG_00654 0.0 M family 8
CMALGNEG_00655 2.7e-09
CMALGNEG_00656 5.6e-08
CMALGNEG_00657 5.8e-109 MA20_06410 E LysE type translocator
CMALGNEG_00658 2.7e-12 IQ PFAM AMP-dependent synthetase and ligase
CMALGNEG_00659 5.3e-12 IQ PFAM AMP-dependent synthetase and ligase
CMALGNEG_00660 1e-137
CMALGNEG_00661 1.8e-270 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CMALGNEG_00662 4.5e-61
CMALGNEG_00664 9.3e-72 S Signal peptide protein, YSIRK family
CMALGNEG_00665 1.4e-54 K response regulator
CMALGNEG_00666 1.1e-37 BP1961 P nitric oxide dioxygenase activity
CMALGNEG_00668 3.6e-282 XK27_07020 S Belongs to the UPF0371 family
CMALGNEG_00669 1.7e-179 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
CMALGNEG_00670 6.8e-161 yvgN C reductase
CMALGNEG_00671 3e-102 yoaK S Protein of unknown function (DUF1275)
CMALGNEG_00672 1.4e-110 drgA C Nitroreductase
CMALGNEG_00673 1.9e-231 pts13C G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
CMALGNEG_00674 9.5e-158 E Alpha/beta hydrolase of unknown function (DUF915)
CMALGNEG_00675 5.6e-77 ywnA K Transcriptional regulator
CMALGNEG_00676 9.5e-150 1.13.11.2 S glyoxalase
CMALGNEG_00677 5.1e-110 XK27_02070 S nitroreductase
CMALGNEG_00678 4e-227 yfnA E amino acid
CMALGNEG_00680 4.8e-25 csbD K CsbD-like
CMALGNEG_00681 8.2e-57 manA 5.3.1.8 G mannose-6-phosphate isomerase
CMALGNEG_00682 9.4e-65 manA 5.3.1.8 G mannose-6-phosphate isomerase
CMALGNEG_00683 1.7e-235 brnQ E Component of the transport system for branched-chain amino acids
CMALGNEG_00684 2.2e-187 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CMALGNEG_00685 4.5e-247 norM V Multidrug efflux pump
CMALGNEG_00686 2.1e-192 pbuX F xanthine permease
CMALGNEG_00688 3.2e-78 xpt 2.4.2.22, 2.4.2.7 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
CMALGNEG_00689 4.6e-123 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
CMALGNEG_00690 6.2e-166 T Histidine kinase
CMALGNEG_00691 1.9e-133 macB2 V ABC transporter, ATP-binding protein
CMALGNEG_00692 0.0 V ABC transporter (permease)
CMALGNEG_00693 6.1e-93 XK27_05000 S metal cluster binding
CMALGNEG_00694 2.6e-30 liaI KT membrane
CMALGNEG_00695 1.4e-15 liaI KT membrane
CMALGNEG_00696 6.1e-26 XK27_09825 V 'abc transporter, ATP-binding protein
CMALGNEG_00697 3.7e-122 S An automated process has identified a potential problem with this gene model
CMALGNEG_00699 1.4e-220 L Transposase
CMALGNEG_00700 4.6e-42 3.6.1.55 F NUDIX domain
CMALGNEG_00701 4.6e-152 mutR K Transcriptional activator, Rgg GadR MutR family
CMALGNEG_00702 1.6e-140 2.7.7.73, 2.7.7.80 E metalloendopeptidase activity
CMALGNEG_00703 7.2e-286 2.7.7.73, 2.7.7.80 E metalloendopeptidase activity
CMALGNEG_00704 6.6e-213 EGP Major facilitator Superfamily
CMALGNEG_00708 8.7e-159 XK27_09825 V abc transporter atp-binding protein
CMALGNEG_00709 1.4e-133 yvfS V ABC-2 type transporter
CMALGNEG_00710 1.5e-192 desK 2.7.13.3 T Histidine kinase
CMALGNEG_00711 4.4e-101 desR K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
CMALGNEG_00712 1.6e-59 sdaAB 4.3.1.17 E L-serine dehydratase
CMALGNEG_00713 1.3e-309 hutU 4.2.1.49 E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CMALGNEG_00714 1.2e-48 S Protein of unknown function (DUF917)
CMALGNEG_00715 1.4e-133 S Protein of unknown function (DUF917)
CMALGNEG_00716 1.2e-280 hutH 4.3.1.3 E Histidine ammonia-lyase
CMALGNEG_00717 3e-111 proWZ P ABC transporter (Permease
CMALGNEG_00718 7.4e-169 proX M ABC transporter, substrate-binding protein, QAT family
CMALGNEG_00719 1.5e-138 proV E abc transporter atp-binding protein
CMALGNEG_00720 9.8e-88 proW P Binding-protein-dependent transport system inner membrane component
CMALGNEG_00721 1.2e-62 bioY S biotin transmembrane transporter activity
CMALGNEG_00722 3.1e-127 yjjG 3.1.3.102, 3.1.3.104, 3.1.3.5, 3.8.1.2 E hydrolase
CMALGNEG_00723 0.0 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
CMALGNEG_00724 9e-278 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CMALGNEG_00725 6.3e-23
CMALGNEG_00726 3e-13
CMALGNEG_00727 5.5e-63 pat 2.3.1.183 M acetyltransferase
CMALGNEG_00728 7.3e-200 asd 1.2.1.11 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CMALGNEG_00729 6.6e-173 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CMALGNEG_00730 8.4e-125 rnc 3.1.26.3 J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
CMALGNEG_00731 0.0 smc D Required for chromosome condensation and partitioning
CMALGNEG_00732 1.2e-196 pheS 6.1.1.20 J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CMALGNEG_00733 4.6e-91 paiA 2.3.1.57 K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
CMALGNEG_00734 0.0 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
CMALGNEG_00737 2e-55 nrdD_1 1.1.98.6, 1.17.4.1 F Ribonucleoside-triphosphate reductase
CMALGNEG_00738 5e-240 XK27_08130 K Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
CMALGNEG_00740 2e-86 S ECF-type riboflavin transporter, S component
CMALGNEG_00741 4.5e-44 pdxK 2.7.1.35 H Belongs to the pyridoxine kinase family
CMALGNEG_00742 8.7e-85 pdxK 2.7.1.35 H Belongs to the pyridoxine kinase family
CMALGNEG_00743 3.3e-82 XK27_01265 S ECF-type riboflavin transporter, S component
CMALGNEG_00744 1.9e-294 yfmM S abc transporter atp-binding protein
CMALGNEG_00745 3.4e-258 noxE P NADH oxidase
CMALGNEG_00746 1.1e-181 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
CMALGNEG_00747 0.0 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CMALGNEG_00748 1.7e-134 srtA 3.4.22.70 M Sortase (surface protein transpeptidase)
CMALGNEG_00749 1.4e-71 yaeR E COG0346 Lactoylglutathione lyase and related lyases
CMALGNEG_00750 5.3e-165 ypuA S secreted protein
CMALGNEG_00751 8.8e-60 L Transposase (IS116 IS110 IS902 family)
CMALGNEG_00752 4.2e-71 L Transposase (IS116 IS110 IS902 family)
CMALGNEG_00754 8.6e-184 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CMALGNEG_00755 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CMALGNEG_00756 2.2e-34 nrdH O Glutaredoxin
CMALGNEG_00757 0.0 acnA 4.2.1.3 C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CMALGNEG_00758 5.1e-212 citZ 2.3.3.1 C Belongs to the citrate synthase family
CMALGNEG_00759 1.5e-222 icd 1.1.1.42 C Isocitrate dehydrogenase
CMALGNEG_00760 7.9e-39 ptsH G phosphocarrier protein Hpr
CMALGNEG_00761 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CMALGNEG_00762 1.6e-249 L Transposase
CMALGNEG_00763 8.6e-265 gapN 1.2.1.9 C Belongs to the aldehyde dehydrogenase family
CMALGNEG_00764 2.1e-28 6.3.2.2, 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
CMALGNEG_00765 2.1e-178 yfmL 3.6.4.13 L DEAD DEAH box helicase
CMALGNEG_00766 2.1e-114 udk 2.7.1.48 F Cytidine monophosphokinase
CMALGNEG_00767 0.0 uup S abc transporter atp-binding protein
CMALGNEG_00769 6.3e-13 MA20_06245 S yiaA/B two helix domain
CMALGNEG_00770 2.2e-131 pip 1.11.1.10 S Alpha beta hydrolase
CMALGNEG_00771 0.0 mprF 2.3.2.3 J Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CMALGNEG_00772 8.7e-150 cobQ S glutamine amidotransferase
CMALGNEG_00773 1.1e-253 murD 3.4.21.10, 6.3.2.13, 6.3.2.9 M Mur ligase, middle domain protein
CMALGNEG_00774 1.2e-123 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CMALGNEG_00775 2.3e-168 ybbR S Protein conserved in bacteria
CMALGNEG_00776 1.5e-250 glmM 5.4.2.10 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CMALGNEG_00777 1.3e-70 gtrA S GtrA-like protein
CMALGNEG_00778 7.9e-123 trmK 2.1.1.217 S SAM-dependent methyltransferase
CMALGNEG_00779 8.1e-148 yqfO 3.5.4.16 S Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CMALGNEG_00780 5.7e-102 zupT P Mediates zinc uptake. May also transport other divalent cations
CMALGNEG_00781 2.1e-207 yurR 1.4.5.1 E oxidoreductase
CMALGNEG_00782 1.9e-161 rfbA 2.7.7.24 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CMALGNEG_00783 8.3e-113 rmlC 1.1.1.133, 5.1.3.13 M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
CMALGNEG_00784 1.9e-205 rfbB 4.2.1.46 M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
CMALGNEG_00787 4.1e-217 hemN H Involved in the biosynthesis of porphyrin-containing compound
CMALGNEG_00788 1.5e-143 fat 3.1.2.21 I Acyl-ACP thioesterase
CMALGNEG_00789 5.9e-143 nagD 2.7.1.25, 3.1.3.41 G Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
CMALGNEG_00790 1.1e-121 ylfI S tigr01906
CMALGNEG_00791 2e-140 hisK 3.1.3.15 E Histidinol phosphatase and related hydrolases of the PHP family
CMALGNEG_00792 2.3e-09 XK27_08080 3.1.1.53 G Exopolysaccharide biosynthesis protein
CMALGNEG_00793 5.6e-92 XK27_08080 3.1.1.53 G Exopolysaccharide biosynthesis protein
CMALGNEG_00794 1.3e-22 XK27_08085
CMALGNEG_00795 5.2e-36 L transposase activity
CMALGNEG_00796 8.2e-22 L Transposase
CMALGNEG_00797 1.6e-55 L transposition
CMALGNEG_00798 8.2e-26 L Integrase core domain protein
CMALGNEG_00799 3.9e-223 L Transposase
CMALGNEG_00801 1.5e-29 hisC 2.6.1.9 E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CMALGNEG_00802 1.6e-154 hisC 2.6.1.9 E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CMALGNEG_00803 5.7e-183 hisZ 2.4.2.17, 6.1.1.21 E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CMALGNEG_00804 1.4e-116 hisG 2.4.2.17 E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
CMALGNEG_00805 2.6e-228 hisD 1.1.1.23, 1.1.1.308 E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CMALGNEG_00806 2.2e-105 hisB 1.1.1.23, 2.6.1.9, 3.1.3.15, 4.2.1.19 E imidazoleglycerol-phosphate dehydratase
CMALGNEG_00807 1.6e-111 hisH E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CMALGNEG_00808 1.7e-131 hisA 5.3.1.16 E 1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CMALGNEG_00809 8.3e-21 hisF 3.5.4.19, 3.6.1.31 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
CMALGNEG_00810 1e-108 hisF 3.5.4.19, 3.6.1.31 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
CMALGNEG_00811 1.2e-60 hisI 3.5.4.19, 3.5.4.25, 3.6.1.31, 5.3.1.16 E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CMALGNEG_00812 1.8e-50 hisE 3.5.4.19, 3.6.1.31, 5.3.1.16 E Phosphoribosyl-ATP
CMALGNEG_00813 5.6e-240 rodA D Belongs to the SEDS family
CMALGNEG_00814 7.8e-222 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CMALGNEG_00815 1e-116 galT 2.7.7.12 G UDPglucose--hexose-1-phosphate uridylyltransferase
CMALGNEG_00816 2e-174 rnz 3.1.26.11 S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
CMALGNEG_00817 6.7e-139 XK27_05435 1.1.1.100 S Belongs to the short-chain dehydrogenases reductases (SDR) family
CMALGNEG_00818 0.0 recJ L Single-strand DNA-specific exonuclease, C terminal domain
CMALGNEG_00819 2e-94 apt 2.4.2.22, 2.4.2.7 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CMALGNEG_00820 1.3e-181 metA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CMALGNEG_00821 2.9e-125 dnaD
CMALGNEG_00822 3.4e-120 nth 4.2.99.18 L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CMALGNEG_00825 1.2e-247 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
CMALGNEG_00826 3.5e-29 xseB 3.1.11.6 L exodeoxyribonuclease VII activity
CMALGNEG_00827 6.6e-159 ispA 2.5.1.1, 2.5.1.10, 2.5.1.29, 2.5.1.90 H Belongs to the FPP GGPP synthase family
CMALGNEG_00828 4.7e-157 rrmJ 2.1.1.226, 2.1.1.227 J Ribosomal RNA large subunit methyltransferase J
CMALGNEG_00829 3.7e-73 argR K Regulates arginine biosynthesis genes
CMALGNEG_00830 5.8e-305 recN L May be involved in recombinational repair of damaged DNA
CMALGNEG_00831 1e-148 DegV S DegV family
CMALGNEG_00832 3.9e-143 ypmR E lipolytic protein G-D-S-L family
CMALGNEG_00833 1.7e-83 ypmS S Protein conserved in bacteria
CMALGNEG_00834 2.8e-39 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
CMALGNEG_00836 1.1e-178 pyrD 1.3.1.14, 1.3.98.1 F Catalyzes the conversion of dihydroorotate to orotate
CMALGNEG_00837 4.6e-131 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CMALGNEG_00838 3.4e-291 leuA 2.3.3.13 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CMALGNEG_00839 7.3e-189 leuB 1.1.1.85 CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
CMALGNEG_00840 2.5e-43 ysdA L Membrane
CMALGNEG_00841 6.8e-275 leuC 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CMALGNEG_00842 3.1e-112 leuD 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CMALGNEG_00843 1.4e-152 sua5 2.7.7.87 J Belongs to the SUA5 family
CMALGNEG_00844 0.0 dnaE 2.7.7.7 L DNA polymerase
CMALGNEG_00845 1.2e-188 pfkA 2.7.1.11 F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
CMALGNEG_00846 1.3e-276 pyk 2.7.1.40, 2.7.7.4 G Belongs to the pyruvate kinase family
CMALGNEG_00849 6.1e-28 Q the current gene model (or a revised gene model) may contain a frame shift
CMALGNEG_00850 6.9e-30 Q the current gene model (or a revised gene model) may contain a frame shift
CMALGNEG_00851 9.5e-178 XK27_08835 S ABC transporter substrate binding protein
CMALGNEG_00852 2.2e-146 XK27_08840 S Belongs to the binding-protein-dependent transport system permease family
CMALGNEG_00853 4.4e-135 XK27_08845 S abc transporter atp-binding protein
CMALGNEG_00854 3e-309 rnjB S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CMALGNEG_00855 1.6e-151 estA CE1 S Putative esterase
CMALGNEG_00856 6.1e-126 XK27_08875 O Zinc-dependent metalloprotease
CMALGNEG_00857 3.3e-14 XK27_08880
CMALGNEG_00858 2.3e-75 fld C Flavodoxin
CMALGNEG_00859 1.3e-282 clcA P Chloride transporter, ClC family
CMALGNEG_00860 8.7e-41 pheA 1.3.1.12, 2.3.1.79, 4.2.1.51, 5.4.99.5 E Chorismate mutase
CMALGNEG_00861 3.5e-206 XK27_05110 P Chloride transporter ClC family
CMALGNEG_00862 1.1e-56 rplS J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
CMALGNEG_00864 5.8e-80
CMALGNEG_00865 2.7e-19 WQ51_02665 S Protein of unknown function (DUF3042)
CMALGNEG_00866 4.9e-165 miaA 2.5.1.75 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CMALGNEG_00867 1.6e-88 ytsP 1.8.4.14 T GAF domain-containing protein
CMALGNEG_00868 3.2e-295 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CMALGNEG_00869 1.6e-174 birA 6.3.4.15 HK Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
CMALGNEG_00870 2.1e-203 metK 2.5.1.6 H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CMALGNEG_00871 5.9e-26 G Domain of unknown function (DUF4832)
CMALGNEG_00872 2.7e-196 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
CMALGNEG_00874 7.2e-231 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CMALGNEG_00875 1.2e-25 epuA S DNA-directed RNA polymerase subunit beta
CMALGNEG_00876 2.4e-124 endA F DNA RNA non-specific endonuclease
CMALGNEG_00877 4.2e-110 tcyB_2 P ABC transporter (permease)
CMALGNEG_00878 8e-115 gltJ P ABC transporter (Permease
CMALGNEG_00879 3.5e-149 peb1A ET ABC-type amino acid transport signal transduction systems, periplasmic component domain
CMALGNEG_00880 2.1e-140 glnQ 3.6.3.21 E abc transporter atp-binding protein
CMALGNEG_00881 9.9e-129 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
CMALGNEG_00882 1.5e-247 vicK 2.7.13.3 T Histidine kinase
CMALGNEG_00883 2.1e-154 vicX 3.1.26.11 S Metal-dependent hydrolases of the beta-lactamase superfamily I
CMALGNEG_00884 5.3e-231 murM 2.3.2.10, 2.3.2.16 V protein involved in methicillin resistance
CMALGNEG_00885 4.6e-146 yidA S hydrolases of the HAD superfamily
CMALGNEG_00886 8.3e-51 XK27_00115 2.3.1.128 K acetyltransferase
CMALGNEG_00887 2.6e-67 ywiB S Domain of unknown function (DUF1934)
CMALGNEG_00888 0.0 pacL 3.6.3.8 P cation transport ATPase
CMALGNEG_00889 1.7e-134 nfrA 1.5.1.38, 1.5.1.39 C nitroreductase
CMALGNEG_00890 9.2e-183 yjjH S Calcineurin-like phosphoesterase
CMALGNEG_00891 2.7e-202 queG 1.17.99.6 C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CMALGNEG_00892 1.6e-182 prfB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CMALGNEG_00893 2.5e-124 ftsE D cell division ATP-binding protein FtsE
CMALGNEG_00894 4.7e-163 ftsX D Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation
CMALGNEG_00895 1.7e-92 mutX 3.6.1.55 F NTP pyrophosphohydrolases including oxidative damage repair enzymes
CMALGNEG_00896 1.3e-178 yubA S permease
CMALGNEG_00897 4.9e-224 G COG0457 FOG TPR repeat
CMALGNEG_00898 4.2e-98 lepB 3.4.21.89 U Belongs to the peptidase S26 family
CMALGNEG_00899 1.8e-234 pepT 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
CMALGNEG_00900 2.9e-90 ebsA S Family of unknown function (DUF5322)
CMALGNEG_00901 3.9e-15 M LysM domain
CMALGNEG_00902 2.5e-121 cmk 1.17.7.4, 2.5.1.19, 2.7.1.26, 2.7.4.25, 2.7.7.2, 6.3.2.1 F Belongs to the cytidylate kinase family. Type 1 subfamily
CMALGNEG_00903 3.5e-86 infC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CMALGNEG_00904 2.1e-28 rpmI J Belongs to the bacterial ribosomal protein bL35 family
CMALGNEG_00905 1.5e-56 rplT J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CMALGNEG_00906 1.6e-24 L Transposase
CMALGNEG_00907 1.7e-47 XK27_03610 K Gnat family
CMALGNEG_00908 6.4e-27 dmpI 5.3.2.6 G Belongs to the 4-oxalocrotonate tautomerase family
CMALGNEG_00909 2.4e-275 pepV 3.5.1.18 E Dipeptidase
CMALGNEG_00910 1.5e-111 ung2 3.2.2.27 L Uracil-DNA glycosylase
CMALGNEG_00912 1.7e-122 rpiA 2.7.1.12, 2.7.1.15, 5.3.1.6 G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CMALGNEG_00913 2.9e-237 deoB 5.4.2.7 G Phosphotransfer between the C1 and C5 carbon atoms of pentose
CMALGNEG_00914 9.6e-47 S Protein of unknown function (DUF1697)
CMALGNEG_00915 1.2e-149 punA 2.4.2.1 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CMALGNEG_00916 6.1e-36 clcA_2 P chloride channel
CMALGNEG_00917 2.2e-67 yfeJ 6.3.5.2 F glutamine amidotransferase
CMALGNEG_00918 4.1e-38 yfeJ 6.3.5.2 F glutamine amidotransferase
CMALGNEG_00919 1.2e-129 deoD 2.4.2.1, 2.4.2.28 F purine nucleoside phosphorylase
CMALGNEG_00920 4.2e-251 cps4A K Cell envelope-like function transcriptional attenuator common domain protein
CMALGNEG_00921 3e-136 cpsB 3.1.3.48 GM Capsular polysaccharide biosynthesis protein
CMALGNEG_00922 1.1e-103 cps4C M biosynthesis protein
CMALGNEG_00923 1.4e-112 cpsD D COG0489 ATPases involved in chromosome partitioning
CMALGNEG_00924 1.7e-249 cpsE M Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
CMALGNEG_00925 9.7e-23 rgpAc GT4 M group 1 family protein
CMALGNEG_00926 2.2e-22 L Transposase
CMALGNEG_00927 8.8e-139 L Integrase core domain
CMALGNEG_00928 6.9e-96 2.7.8.12 GT2 S Glycosyltransferase like family 2
CMALGNEG_00929 1.3e-199 L Transposase
CMALGNEG_00930 1.3e-23 L Transposase
CMALGNEG_00931 1.1e-235 cps1C S Polysaccharide biosynthesis protein
CMALGNEG_00932 3.2e-71 L COG2801 Transposase and inactivated derivatives
CMALGNEG_00933 1.1e-60 L Integrase core domain
CMALGNEG_00934 3.3e-37 L transposase activity
CMALGNEG_00935 1.2e-70 rfbP 2.7.8.6 M Bacterial sugar transferase
CMALGNEG_00936 1.4e-72 cpsF M Oligosaccharide biosynthesis protein Alg14 like
CMALGNEG_00937 1.9e-41 pssE S Glycosyltransferase family 28 C-terminal domain
CMALGNEG_00938 6.5e-72 M Glycosyltransferase sugar-binding region containing DXD motif
CMALGNEG_00939 7.8e-16
CMALGNEG_00940 6.4e-33 cpsJ S Glycosyltransferase like family 2
CMALGNEG_00941 6.2e-112 L the current gene model (or a revised gene model) may contain a frame shift
CMALGNEG_00942 3.1e-37 L Transposase
CMALGNEG_00943 2.2e-94 V VanZ like family
CMALGNEG_00944 5.4e-15 supH 3.1.3.102, 3.1.3.104 S Sucrose-6F-phosphate phosphohydrolase
CMALGNEG_00945 5.6e-65 supH 3.1.3.102, 3.1.3.104 Q phosphatase activity
CMALGNEG_00946 1.1e-95 pgm G Belongs to the phosphoglycerate mutase family
CMALGNEG_00947 7.2e-104 G Belongs to the phosphoglycerate mutase family
CMALGNEG_00948 2.5e-99 G Belongs to the phosphoglycerate mutase family
CMALGNEG_00949 1.1e-198 S hmm pf01594
CMALGNEG_00950 2e-18 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
CMALGNEG_00951 2.6e-97 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
CMALGNEG_00952 3.2e-36 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
CMALGNEG_00953 4.9e-39 S granule-associated protein
CMALGNEG_00954 8.5e-290 S unusual protein kinase
CMALGNEG_00955 5.5e-34 estA E Lysophospholipase L1 and related esterases
CMALGNEG_00956 1.9e-59 estA E GDSL-like protein
CMALGNEG_00957 1.1e-158 rssA S Phospholipase, patatin family
CMALGNEG_00958 4.3e-83 3.4.16.4 M Belongs to the peptidase S11 family
CMALGNEG_00959 2.3e-26 3.4.16.4 M Belongs to the peptidase S11 family
CMALGNEG_00960 3.9e-24 3.4.16.4 M Belongs to the peptidase S11 family
CMALGNEG_00961 2.9e-21 dacA1 3.4.16.4 M Belongs to the peptidase S11 family
CMALGNEG_00962 5.4e-19 dacA1 3.4.16.4 M Belongs to the peptidase S11 family
CMALGNEG_00963 4e-215 yeaB K Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CMALGNEG_00964 7.2e-126 ung 3.2.2.27 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CMALGNEG_00965 1.1e-234 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
CMALGNEG_00966 5.7e-66 S the current gene model (or a revised gene model) may contain a frame shift
CMALGNEG_00967 5e-38 P membrane protein (DUF2207)
CMALGNEG_00968 6e-185 acoA 1.2.4.1, 1.2.4.4 C Dehydrogenase E1 component
CMALGNEG_00969 3.7e-182 acoB 1.2.4.1, 1.2.4.4 C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
CMALGNEG_00970 1.8e-198 acoC 2.3.1.12 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
CMALGNEG_00971 0.0 lpdA 1.8.1.4 C Dehydrogenase
CMALGNEG_00972 2.6e-20 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
CMALGNEG_00973 3.6e-82 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
CMALGNEG_00974 8.5e-266 3.5.1.28 NU amidase activity
CMALGNEG_00975 1.9e-37 3.5.1.28 NU amidase activity
CMALGNEG_00976 2.4e-134 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
CMALGNEG_00977 7.6e-66 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
CMALGNEG_00978 3.8e-54 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
CMALGNEG_00979 2e-139 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
CMALGNEG_00980 4e-165 yclN P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CMALGNEG_00981 1.9e-167 fatC P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CMALGNEG_00982 6.8e-136 yclP 3.6.3.34 P abc transporter atp-binding protein
CMALGNEG_00983 6.5e-177 fatB P ABC-type enterochelin transport system, periplasmic component
CMALGNEG_00984 4.6e-152 ycdO P periplasmic lipoprotein involved in iron transport
CMALGNEG_00985 1.5e-233 ycdB P peroxidase
CMALGNEG_00986 3.9e-301 ywbL P COG0672 High-affinity Fe2 Pb2 permease
CMALGNEG_00987 5.8e-121 tatC U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CMALGNEG_00988 4.6e-25 tatA U protein secretion
CMALGNEG_00989 2.3e-23 L Transposase
CMALGNEG_00990 1.3e-48 malR K Transcriptional regulator
CMALGNEG_00991 3.4e-304 malQ 2.4.1.25 GH77 G 4-alpha-glucanotransferase
CMALGNEG_00992 0.0 glgP 2.4.1.1 GT35 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
CMALGNEG_00993 3.7e-09
CMALGNEG_00995 1.3e-187 lplA 6.3.1.20 H Lipoate-protein ligase
CMALGNEG_00996 1.6e-194 xerS D Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division
CMALGNEG_00997 0.0 pepN 3.4.11.2 E aminopeptidase
CMALGNEG_00998 2.4e-113 phoU P Plays a role in the regulation of phosphate uptake
CMALGNEG_00999 1.7e-139 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
CMALGNEG_01000 1e-150 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
CMALGNEG_01001 5.9e-155 pstA P phosphate transport system permease
CMALGNEG_01002 2.5e-156 pstC P probably responsible for the translocation of the substrate across the membrane
CMALGNEG_01003 4.3e-158 pstS P phosphate
CMALGNEG_01004 1.5e-255 rsmF 2.1.1.176, 2.1.1.178 J NOL1 NOP2 sun family protein
CMALGNEG_01005 1.1e-141 suhB 3.1.3.25 G Belongs to the inositol monophosphatase superfamily
CMALGNEG_01006 1.9e-43 yktA S Belongs to the UPF0223 family
CMALGNEG_01007 4.2e-71 spxA 1.20.4.1 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
CMALGNEG_01008 2.6e-174 ribF 2.7.1.26, 2.7.7.2 H Belongs to the ribF family
CMALGNEG_01009 2.4e-150 truB 5.4.99.25 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CMALGNEG_01010 5.2e-22 XK27_04775 P Hemerythrin HHE cation binding domain protein
CMALGNEG_01011 3.6e-136 XK27_04775 S hemerythrin HHE cation binding domain
CMALGNEG_01012 1.1e-110 hsdS2 2.1.1.72 V Type I restriction modification DNA specificity domain
CMALGNEG_01013 3.5e-88 tpx 1.11.1.15 O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CMALGNEG_01014 9.3e-62 S haloacid dehalogenase-like hydrolase
CMALGNEG_01015 1.8e-59 Q phosphatase activity
CMALGNEG_01016 3.5e-241 metY 2.5.1.49 E o-acetylhomoserine
CMALGNEG_01017 0.0 pcrA 3.6.4.12 L ATP-dependent DNA helicase
CMALGNEG_01018 1.8e-240 agcS E (Alanine) symporter
CMALGNEG_01019 1.3e-246 mnmE S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CMALGNEG_01020 1.4e-104 yfiF3 K sequence-specific DNA binding
CMALGNEG_01021 9.8e-35 3.1.3.6, 3.1.4.16 F nucleotide catabolic process
CMALGNEG_01022 8.1e-114 sasH 3.1.3.5, 3.6.1.45 F Belongs to the 5'-nucleotidase family
CMALGNEG_01024 1.8e-67 yecS P ABC transporter (Permease
CMALGNEG_01025 8.8e-134 yckB ET Belongs to the bacterial solute-binding protein 3 family
CMALGNEG_01026 1e-103 nylA 3.5.1.4 J Belongs to the amidase family
CMALGNEG_01027 7.9e-266 dtpT E transporter
CMALGNEG_01029 1.2e-63 nylA 3.5.1.4 J Belongs to the amidase family
CMALGNEG_01030 7.5e-112 pyrE 2.4.2.10, 4.1.1.23 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CMALGNEG_01031 7e-127 pyrF 4.1.1.23 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
CMALGNEG_01032 3.4e-61 csm6 S Psort location Cytoplasmic, score
CMALGNEG_01033 1.9e-203 csm5 L CRISPR-associated RAMP protein, Csm5 family
CMALGNEG_01034 1.4e-164 csm4 L CRISPR-associated RAMP protein, Csm4 family
CMALGNEG_01035 1.1e-116 csm3 L RAMP superfamily
CMALGNEG_01036 5.6e-62 csm2 L Pfam:DUF310
CMALGNEG_01037 0.0 csm1 S CRISPR-associated protein Csm1 family
CMALGNEG_01038 1.3e-131 cas6 S CRISPR-associated endoribonuclease Cas6
CMALGNEG_01039 3.7e-54 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CMALGNEG_01040 1.8e-184 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CMALGNEG_01041 3.2e-175 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
CMALGNEG_01042 6.3e-148 pyrK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )
CMALGNEG_01043 3.2e-95 thiJ 2.7.11.1, 3.5.1.124 S DJ-1 family
CMALGNEG_01044 2.1e-98 S TraX protein
CMALGNEG_01046 1.7e-309 FbpA K RNA-binding protein homologous to eukaryotic snRNP
CMALGNEG_01047 6.5e-266 S Psort location CytoplasmicMembrane, score
CMALGNEG_01048 5.1e-26 dinF V drug transmembrane transporter activity
CMALGNEG_01049 9.6e-72 dinF V Mate efflux family protein
CMALGNEG_01050 3.6e-18 yclQ P ABC-type enterochelin transport system, periplasmic component
CMALGNEG_01051 1.8e-24 yclQ P ABC-type enterochelin transport system, periplasmic component
CMALGNEG_01052 4.1e-118 gph 3.1.3.18 S HAD hydrolase, family IA, variant 1
CMALGNEG_01053 2.6e-143 2.4.2.3 F Phosphorylase superfamily
CMALGNEG_01056 1.2e-79 S Alpha/beta hydrolase of unknown function (DUF915)
CMALGNEG_01057 1.8e-16 S Alpha/beta hydrolase of unknown function (DUF915)
CMALGNEG_01058 6e-08 S Hydrolases of the alpha beta superfamily
CMALGNEG_01059 2.7e-106 adhB 1.1.1.1, 1.1.1.14 E Dehydrogenase
CMALGNEG_01060 8.1e-52 adhB 1.1.1.1, 1.1.1.14 E Dehydrogenase
CMALGNEG_01061 1e-209 hemH 4.99.1.1, 4.99.1.9 H Catalyzes the ferrous insertion into protoporphyrin IX
CMALGNEG_01062 1.2e-158 czcD P cation diffusion facilitator family transporter
CMALGNEG_01063 1.2e-103 K Transcriptional regulator, TetR family
CMALGNEG_01065 6.1e-13 L Transposase
CMALGNEG_01066 1e-193 L Transposase
CMALGNEG_01067 3e-133 budA 4.1.1.5 H Belongs to the alpha-acetolactate decarboxylase family
CMALGNEG_01068 0.0 alsS 2.2.1.6 EH Belongs to the TPP enzyme family
CMALGNEG_01069 6.6e-61 EGP Major facilitator Superfamily
CMALGNEG_01070 3.9e-136 speB 3.5.3.11 E hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
CMALGNEG_01071 1.3e-212 pqqE C radical SAM domain protein
CMALGNEG_01074 1.8e-156 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
CMALGNEG_01075 4.1e-53 K peptidyl-tyrosine sulfation
CMALGNEG_01079 0.0 lepA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
CMALGNEG_01080 3.9e-19 IQ Acetoin reductase
CMALGNEG_01081 6.8e-51 IQ Acetoin reductase
CMALGNEG_01082 2.7e-48 pspE P Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CMALGNEG_01083 1.7e-75 ndk 2.7.4.6 F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
CMALGNEG_01084 1.9e-152 XK27_05470 E Methionine synthase
CMALGNEG_01085 6.6e-259 trmFO 2.1.1.74 J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CMALGNEG_01086 6.9e-251 T PhoQ Sensor
CMALGNEG_01087 2.2e-122 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
CMALGNEG_01088 5.1e-153 S TraX protein
CMALGNEG_01089 0.0 topA 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CMALGNEG_01090 2.4e-158 dprA LU DNA protecting protein DprA
CMALGNEG_01091 1.1e-167 GK ROK family
CMALGNEG_01092 1.5e-135 rnhB 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CMALGNEG_01093 1.4e-158 ylqF S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CMALGNEG_01094 6.9e-127 K DNA-binding helix-turn-helix protein
CMALGNEG_01095 8.6e-90 niaR S small molecule binding protein (contains 3H domain)
CMALGNEG_01096 2.4e-87 niaX
CMALGNEG_01097 1.3e-269 ffh 3.6.5.4 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CMALGNEG_01098 1.1e-53 ylxM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CMALGNEG_01099 2e-126 gntR1 K transcriptional
CMALGNEG_01100 1.1e-302 guaA 2.3.1.128, 6.3.5.2 F Catalyzes the synthesis of GMP from XMP
CMALGNEG_01101 0.0 sthIM 2.1.1.72 L Adenine specific DNA methylase Mod
CMALGNEG_01102 0.0 res_1 3.1.21.5 S Type III restriction
CMALGNEG_01103 1.1e-20
CMALGNEG_01105 7.4e-110 adhP 1.1.1.1 C alcohol dehydrogenase
CMALGNEG_01106 2.3e-62 adhP 1.1.1.1 C alcohol dehydrogenase
CMALGNEG_01107 3.1e-142 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CMALGNEG_01108 1.4e-158 aatB ET ABC transporter substrate-binding protein
CMALGNEG_01109 3.4e-112 glnQ 3.6.3.21 E abc transporter atp-binding protein
CMALGNEG_01110 5.3e-105 artQ P ABC transporter (Permease
CMALGNEG_01111 2.5e-58 phnA P Alkylphosphonate utilization operon protein PhnA
CMALGNEG_01112 0.0 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
CMALGNEG_01113 4.5e-166 cpsY K Transcriptional regulator
CMALGNEG_01114 6.6e-71 L transposition
CMALGNEG_01115 1.9e-119 mur1 NU muramidase
CMALGNEG_01116 1.5e-170 yeiH S Membrane
CMALGNEG_01117 1.7e-08
CMALGNEG_01118 2.1e-293 adcA P Belongs to the bacterial solute-binding protein 9 family
CMALGNEG_01119 3.7e-88 XK27_10720 D peptidase activity
CMALGNEG_01120 3.4e-79 hsdM 2.1.1.72 V HsdM N-terminal domain
CMALGNEG_01121 1.1e-08 mycA 4.2.1.53 S Myosin-crossreactive antigen
CMALGNEG_01122 2.9e-154 glcU U Glucose uptake
CMALGNEG_01123 5.2e-113 hsdM 2.1.1.72 V type I restriction-modification system
CMALGNEG_01124 5.2e-56 hsdS 2.1.1.72, 3.1.21.3 V type I restriction modification DNA specificity domain
CMALGNEG_01125 5.4e-104 L Transposase
CMALGNEG_01126 6.3e-54 L Transposase
CMALGNEG_01127 3.3e-98 cysE 2.3.1.30 E serine acetyltransferase
CMALGNEG_01128 3.5e-219 metC 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
CMALGNEG_01129 2.3e-170 mccA 2.5.1.134, 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
CMALGNEG_01130 4.4e-194 3.1.21.3 L Subunit R is required for both nuclease and ATPase activities, but not for modification
CMALGNEG_01131 8.6e-94 L Transposase
CMALGNEG_01132 1.6e-88 L Transposase
CMALGNEG_01133 0.0 copB 3.6.3.4 P P-type ATPase
CMALGNEG_01134 8e-59 L Transposase
CMALGNEG_01135 2.9e-131 L Transposase
CMALGNEG_01136 9.4e-43 K Cold-Shock Protein
CMALGNEG_01137 1.6e-249 L Transposase
CMALGNEG_01138 5.4e-32 cspD K Cold shock protein domain
CMALGNEG_01139 5.8e-41 pepD E dipeptidase activity
CMALGNEG_01140 8e-90 pepD E Dipeptidase
CMALGNEG_01141 8.7e-162 whiA K May be required for sporulation
CMALGNEG_01142 2.8e-182 ybhK S Required for morphogenesis under gluconeogenic growth conditions
CMALGNEG_01143 1.2e-163 rapZ S Displays ATPase and GTPase activities
CMALGNEG_01144 5.3e-136 yejC S cyclic nucleotide-binding protein
CMALGNEG_01145 4.2e-18 D nuclear chromosome segregation
CMALGNEG_01146 2.5e-94 queF 1.7.1.13 S Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily
CMALGNEG_01147 3.9e-133 queE 1.97.1.4, 4.3.99.3 H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
CMALGNEG_01148 2.2e-81 queD 4.1.2.50, 4.2.3.12 H synthase
CMALGNEG_01149 2e-123 queC 6.3.4.20 F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CMALGNEG_01150 3e-63 tdcF 3.5.99.10 J endoribonuclease L-PSP
CMALGNEG_01151 3e-13
CMALGNEG_01152 2.4e-30
CMALGNEG_01153 1.5e-07
CMALGNEG_01154 1.7e-262 asnS 6.1.1.22 J Catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
CMALGNEG_01155 6.5e-218 aspB 2.6.1.1, 2.6.1.14 E Aminotransferase
CMALGNEG_01156 3.1e-81 ypmB S Protein conserved in bacteria
CMALGNEG_01157 0.0 dinG 2.7.7.7, 3.6.4.12 L helicase involved in DNA repair and perhaps also replication
CMALGNEG_01158 4e-121 ycbL 3.1.2.6 S COG0491 Zn-dependent hydrolases, including glyoxylases
CMALGNEG_01159 4.8e-171 yufQ S Belongs to the binding-protein-dependent transport system permease family
CMALGNEG_01160 4.7e-191 yufP S Belongs to the binding-protein-dependent transport system permease family
CMALGNEG_01161 2.7e-280 xylG 3.6.3.17 S ABC transporter, ATP-binding protein
CMALGNEG_01162 1.5e-189 tcsA S ABC-type transport system, periplasmic component surface lipoprotein
CMALGNEG_01163 2.2e-47 cdd 2.4.2.2, 3.5.4.5 F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
CMALGNEG_01164 1.5e-62 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CMALGNEG_01165 5.5e-29 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CMALGNEG_01166 7.5e-101 pdp 2.4.2.2, 2.4.2.4 F Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate
CMALGNEG_01167 1.3e-24 pdp 2.4.2.2, 2.4.2.4 F phosphorylase activity
CMALGNEG_01168 1.8e-107 rsmC 2.1.1.172 J Methyltransferase small domain protein
CMALGNEG_01169 2.5e-172 coaA 2.7.1.33 F Pantothenic acid kinase
CMALGNEG_01170 2.1e-30 rpsT J rRNA binding
CMALGNEG_01171 3.9e-122 L Transposase
CMALGNEG_01172 1.2e-165 L integrase core domain
CMALGNEG_01173 9.2e-110 T PhoQ Sensor
CMALGNEG_01174 1.1e-13 T PhoQ Sensor
CMALGNEG_01175 4.3e-41 T PhoQ Sensor
CMALGNEG_01176 6.4e-66 T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
CMALGNEG_01177 0.0 fhs 6.3.4.3 F Belongs to the formate--tetrahydrofolate ligase family
CMALGNEG_01178 6.2e-120 coaB 4.1.1.36, 6.3.2.5 H Phosphopantothenate-cysteine ligase
CMALGNEG_01179 4.8e-94 coaBC 4.1.1.36, 6.3.2.5 H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CMALGNEG_01180 1.6e-92 panT S ECF transporter, substrate-specific component
CMALGNEG_01181 0.0 pgm 5.4.2.2, 5.4.2.8 G Phosphoglucomutase
CMALGNEG_01182 7.3e-166 metF 1.5.1.20 C reductase
CMALGNEG_01183 0.0 metE 2.1.1.14 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CMALGNEG_01185 7.1e-217 sip L Belongs to the 'phage' integrase family
CMALGNEG_01186 6e-39 K Helix-turn-helix
CMALGNEG_01187 5.5e-17 K TRANSCRIPTIONal
CMALGNEG_01192 6.9e-22
CMALGNEG_01193 3e-164 KL Phage plasmid primase P4 family
CMALGNEG_01194 2e-296 S DNA primase
CMALGNEG_01196 2.3e-12
CMALGNEG_01198 2e-103
CMALGNEG_01199 1.4e-66 S tRNA_anti-like
CMALGNEG_01200 4e-22 L Belongs to the 'phage' integrase family
CMALGNEG_01201 3e-44 ymbI L transposase activity
CMALGNEG_01202 2.6e-72 hpaIIR 3.1.21.4 L HpaII restriction endonuclease
CMALGNEG_01203 1.7e-146 2.1.1.37 H cytosine-specific methyltransferase
CMALGNEG_01204 5.1e-106 V Abi-like protein
CMALGNEG_01205 0.0 pabB 2.6.1.85, 4.1.3.27, 4.1.3.38 EH component I
CMALGNEG_01206 0.0 3.6.3.8 P cation transport ATPase
CMALGNEG_01207 8.9e-104 L Transposase
CMALGNEG_01208 1.2e-135 L Transposase
CMALGNEG_01209 5.2e-229 dltD M Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CMALGNEG_01210 1.7e-35 dltC 6.1.1.13 IQ Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
CMALGNEG_01211 4.6e-238 dltB M Membrane protein involved in D-alanine export
CMALGNEG_01212 9.3e-297 dltA 6.1.1.13 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
CMALGNEG_01213 1.7e-09 S D-Ala-teichoic acid biosynthesis protein
CMALGNEG_01214 0.0 XK27_10035 V abc transporter atp-binding protein
CMALGNEG_01215 0.0 yfiB1 V abc transporter atp-binding protein
CMALGNEG_01216 2.4e-107 pvaA M lytic transglycosylase activity
CMALGNEG_01217 6e-177 ndpA S 37-kD nucleoid-associated bacterial protein
CMALGNEG_01218 1.8e-234 glyA 2.1.2.1 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CMALGNEG_01219 9.7e-109 ywlC 2.7.7.87, 3.1.3.48 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
CMALGNEG_01220 1.2e-154 prmB 2.1.1.297, 2.1.1.298 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
CMALGNEG_01221 3e-193 prfA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CMALGNEG_01222 4.5e-111 tdk 2.7.1.21 F thymidine kinase
CMALGNEG_01223 4.6e-188 add 3.5.4.4 F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CMALGNEG_01224 8.9e-155 gst O Glutathione S-transferase
CMALGNEG_01225 1e-184 nrnA 3.1.13.3, 3.1.3.7 S domain protein
CMALGNEG_01226 1.9e-175 apbE 2.7.1.180 H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
CMALGNEG_01227 2e-45 rpmE2 J 50S ribosomal protein L31
CMALGNEG_01228 8.8e-229 mntH P Mn2 and Fe2 transporters of the NRAMP family
CMALGNEG_01230 3.2e-45 L Transposase
CMALGNEG_01231 0.0 ileS 6.1.1.5 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CMALGNEG_01232 3.3e-134 divIVA D Cell division protein DivIVA
CMALGNEG_01233 4.7e-143 ylmH T S4 RNA-binding domain
CMALGNEG_01234 8.8e-35 yggT D integral membrane protein
CMALGNEG_01235 2e-95 sepF D Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
CMALGNEG_01236 2.7e-123 ylmE S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CMALGNEG_01237 5.4e-237 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CMALGNEG_01238 1.1e-251 ftsA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
CMALGNEG_01239 6.9e-177 divIB D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
CMALGNEG_01240 1e-201 murG 2.4.1.227 GT28 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CMALGNEG_01241 1.6e-252 murD 6.3.2.9 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CMALGNEG_01243 0.0 typA T GTP-binding protein TypA
CMALGNEG_01244 1.6e-177 glk 2.7.1.2 G Glucokinase
CMALGNEG_01245 8.4e-28 yqgQ S protein conserved in bacteria
CMALGNEG_01246 1.1e-80 perR P Belongs to the Fur family
CMALGNEG_01247 1.6e-91 dps P Belongs to the Dps family
CMALGNEG_01248 1.5e-115 pilD 3.4.23.43 NOU Bacterial Peptidase A24 N-terminal domain
CMALGNEG_01249 1.4e-190 3.5.2.6 V D-alanyl-D-alanine carboxypeptidase
CMALGNEG_01250 8.5e-113 sodA 1.15.1.1 C radicals which are normally produced within the cells and which are toxic to biological systems
CMALGNEG_01251 2.4e-184 holA 2.7.7.7 L DNA polymerase III delta subunit
CMALGNEG_01252 0.0 ppc 4.1.1.31 H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CMALGNEG_01253 6.2e-56 S Domain of unknown function (DUF4430)
CMALGNEG_01254 5.1e-73 S Psort location CytoplasmicMembrane, score
CMALGNEG_01255 1.8e-135 htpX O Belongs to the peptidase M48B family
CMALGNEG_01256 1.5e-92 lemA S LemA family
CMALGNEG_01257 8.8e-157 spd F DNA RNA non-specific endonuclease
CMALGNEG_01258 3e-38
CMALGNEG_01259 2.5e-44
CMALGNEG_01261 9.3e-68 hsdS 3.1.21.3 L Type I restriction modification DNA specificity domain
CMALGNEG_01262 7.3e-289 hsdM 2.1.1.72 V N-6 DNA Methylase
CMALGNEG_01263 0.0 hsdR 3.1.21.3 V Type I restriction enzyme R protein N terminus (HSDR_N)
CMALGNEG_01264 1.4e-44 sdh 1.1.1.276, 1.1.1.313, 1.1.1.381 S Belongs to the short-chain dehydrogenases reductases (SDR) family
CMALGNEG_01265 8.3e-76 sdh 1.1.1.276, 1.1.1.313, 1.1.1.381 S Belongs to the short-chain dehydrogenases reductases (SDR) family
CMALGNEG_01266 8e-18 MA20_36090 S Protein of unknown function (DUF2974)
CMALGNEG_01267 1.7e-10 MA20_36090 S Protein of unknown function (DUF2974)
CMALGNEG_01268 1.4e-113 1.14.14.5 C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CMALGNEG_01269 2.1e-27 P Hemerythrin HHE cation binding domain protein
CMALGNEG_01270 2.2e-144 XK27_00880 3.5.1.28 M Glycosyl hydrolase, family 25
CMALGNEG_01271 7.9e-82 ybaK S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CMALGNEG_01272 5.1e-116 pgm6 5.4.2.11, 5.4.2.12 G Phosphoglycerate mutase
CMALGNEG_01273 9.8e-174 S hydrolase
CMALGNEG_01274 5.9e-16
CMALGNEG_01275 1.5e-154 M LysM domain
CMALGNEG_01276 1.9e-286 lysS 6.1.1.6 J Belongs to the class-II aminoacyl-tRNA synthetase family
CMALGNEG_01277 1.2e-33 S SIR2-like domain
CMALGNEG_01278 5.2e-29 S SIR2-like domain
CMALGNEG_01279 1.2e-224 mutH L DNA mismatch repair enzyme MutH
CMALGNEG_01280 6e-209 dcm 2.1.1.37 H C-5 cytosine-specific DNA methylase
CMALGNEG_01281 4.8e-11
CMALGNEG_01282 7.3e-234 mntH P H( )-stimulated, divalent metal cation uptake system
CMALGNEG_01283 1.1e-33 XK27_12190 S protein conserved in bacteria
CMALGNEG_01285 8.4e-88 bioY S biotin synthase
CMALGNEG_01286 8.1e-46 S CHY zinc finger
CMALGNEG_01287 3.4e-252 yegQ O Peptidase U32
CMALGNEG_01288 2e-177 yegQ O Peptidase U32
CMALGNEG_01290 5.5e-69 ytxH S General stress protein
CMALGNEG_01292 4e-147 lgt 2.1.1.199 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CMALGNEG_01293 1.7e-168 hprK F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CMALGNEG_01294 9.9e-42 pspC KT PspC domain
CMALGNEG_01295 0.0 yhgF K Transcriptional accessory protein
CMALGNEG_01297 1.2e-155 XK27_03015 S permease
CMALGNEG_01298 2.3e-145 ycgQ S TIGR03943 family
CMALGNEG_01299 9e-195 S CRISPR-associated protein Csn2 subfamily St
CMALGNEG_01300 1.8e-53 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CMALGNEG_01301 4.2e-172 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CMALGNEG_01302 0.0 cas9 L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
CMALGNEG_01303 1.1e-94
CMALGNEG_01304 4.8e-33 estA E GDSL-like Lipase/Acylhydrolase
CMALGNEG_01305 7.8e-50 dam 2.1.1.72 L D12 class N6 adenine-specific DNA methyltransferase
CMALGNEG_01306 1e-31 K Cro/C1-type HTH DNA-binding domain
CMALGNEG_01307 3.2e-46
CMALGNEG_01308 8.9e-20
CMALGNEG_01309 1.7e-257 rumA 2.1.1.190 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CMALGNEG_01310 4.5e-97 mip S hydroperoxide reductase activity
CMALGNEG_01311 7e-203 I acyl-CoA dehydrogenase
CMALGNEG_01312 2.2e-149 ydiA P C4-dicarboxylate transporter malic acid transport protein
CMALGNEG_01313 6.4e-252 msrR K Transcriptional regulator
CMALGNEG_01314 6.7e-153 pheA 4.2.1.51 E Prephenate dehydratase
CMALGNEG_01315 1.7e-87 aroK 1.1.1.25, 2.7.1.71, 4.2.1.10, 4.2.3.4 F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CMALGNEG_01316 2.6e-236 aroA 1.3.1.12, 1.3.1.43, 2.5.1.19 E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
CMALGNEG_01317 3e-173 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
CMALGNEG_01318 3.2e-53 yheA S Belongs to the UPF0342 family
CMALGNEG_01319 2.2e-207 tyrA 1.3.1.12, 1.3.1.43 E prephenate dehydrogenase
CMALGNEG_01320 4.5e-219 aroC 4.2.3.5 E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CMALGNEG_01321 4.8e-174 aroB 2.7.1.71, 4.2.3.4 E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CMALGNEG_01322 1.7e-162 aroE 1.1.1.25 E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CMALGNEG_01323 8.6e-122 aroD 1.1.1.25, 4.2.1.10 E Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
CMALGNEG_01324 2e-219 ywbD 2.1.1.191 J Methyltransferase
CMALGNEG_01325 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
CMALGNEG_01326 2e-25 WQ51_00785
CMALGNEG_01327 9.6e-247 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
CMALGNEG_01328 1e-78 yueI S Protein of unknown function (DUF1694)
CMALGNEG_01329 1.3e-207 glxK 2.7.1.165 G Belongs to the glycerate kinase type-1 family
CMALGNEG_01330 6.6e-101 yyaQ V Protein conserved in bacteria
CMALGNEG_01331 2.8e-28 yyaQ S YjbR
CMALGNEG_01332 4.4e-183 ccpA K Catabolite control protein A
CMALGNEG_01333 4.2e-211 pepQ 3.4.13.9 E Belongs to the peptidase M24B family
CMALGNEG_01334 1.7e-63 yugI 5.3.1.9 J RNA binding protein, contains ribosomal protein S1 domain
CMALGNEG_01335 9.6e-277 ppiB 5.2.1.8 G PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CMALGNEG_01336 1.1e-80 smpB O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
CMALGNEG_01337 0.0 rnr J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
CMALGNEG_01338 2e-33 secG U Preprotein translocase subunit SecG
CMALGNEG_01339 2.5e-220 mdtG EGP Major facilitator Superfamily
CMALGNEG_01340 1.1e-104 coaE 2.7.1.24, 3.2.2.23, 4.2.99.18 GH23 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CMALGNEG_01341 7.1e-155 fpg 3.2.2.23, 4.2.99.18 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
CMALGNEG_01342 8.3e-165 era M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CMALGNEG_01343 1.7e-64 dgkA 2.7.1.107, 2.7.1.66 M Diacylglycerol kinase
CMALGNEG_01344 5.9e-88 ybeY 2.6.99.2, 3.5.4.5 S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CMALGNEG_01345 6.8e-53 licT K transcriptional antiterminator
CMALGNEG_01346 5.8e-64 licT K transcriptional antiterminator
CMALGNEG_01347 4.9e-105 recR L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CMALGNEG_01348 0.0 pbp2b 3.4.16.4 M penicillin-binding protein
CMALGNEG_01349 7.8e-149 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CMALGNEG_01350 3.9e-156 folD 1.5.1.5, 3.5.4.9 F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CMALGNEG_01351 7.5e-23 I Alpha/beta hydrolase family
CMALGNEG_01352 1.5e-35 yugF I carboxylic ester hydrolase activity
CMALGNEG_01353 2.2e-45 K sequence-specific DNA binding
CMALGNEG_01354 2.4e-104 1.1.1.133, 5.1.3.13 M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
CMALGNEG_01356 0.0 feoB P transporter of a GTP-driven Fe(2 ) uptake system
CMALGNEG_01357 3.1e-78 feoA P FeoA domain protein
CMALGNEG_01358 2.2e-131 glnQ 3.6.3.21 E abc transporter atp-binding protein
CMALGNEG_01359 3.7e-117 WQ51_01820 P Binding-protein-dependent transport system inner membrane component
CMALGNEG_01360 1.3e-34 ykuJ S protein conserved in bacteria
CMALGNEG_01361 1.2e-180 argF 2.1.3.3 E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CMALGNEG_01362 0.0 clpE O Belongs to the ClpA ClpB family
CMALGNEG_01363 1.8e-86 mutT 3.5.4.33, 3.6.1.13, 3.6.1.55 L Belongs to the Nudix hydrolase family
CMALGNEG_01364 3.7e-48 XK27_09445 S Domain of unknown function (DUF1827)
CMALGNEG_01365 1.2e-65 S oxidoreductase
CMALGNEG_01366 3.4e-233 murN 2.3.2.10, 2.3.2.16 V FemAB family
CMALGNEG_01367 3.7e-70 M Pfam SNARE associated Golgi protein
CMALGNEG_01368 1.3e-29 S Domain of Unknown Function with PDB structure (DUF3862)
CMALGNEG_01369 1.1e-44 S Domain of Unknown Function with PDB structure (DUF3862)
CMALGNEG_01372 8.4e-205 rpsA 1.17.7.4 J ribosomal protein S1
CMALGNEG_01375 4.8e-16 S Protein of unknown function (DUF2969)
CMALGNEG_01376 2.4e-200 ilvE 2.6.1.42 E Aminotransferase
CMALGNEG_01377 0.0 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
CMALGNEG_01378 0.0 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
CMALGNEG_01379 7.1e-102 plsY 2.3.1.15, 3.5.1.104 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
CMALGNEG_01380 4.9e-15 L Helix-hairpin-helix DNA-binding motif class 1
CMALGNEG_01381 1.4e-29 S Domain of unknown function (DUF1912)
CMALGNEG_01382 1.2e-177 mmuM 1.5.1.20, 2.1.1.10 H Homocysteine
CMALGNEG_01383 1.5e-250 mmuP E amino acid
CMALGNEG_01384 3e-110 engB D Necessary for normal cell division and for the maintenance of normal septation
CMALGNEG_01385 2e-225 clpX O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CMALGNEG_01386 9.7e-22
CMALGNEG_01387 3.4e-91 folA 1.5.1.3, 1.5.1.47, 2.1.1.45, 3.5.4.12 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CMALGNEG_01388 2.2e-167 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CMALGNEG_01389 1.7e-218 mvaS 2.3.3.10 I synthase
CMALGNEG_01390 2.7e-233 mvaA 1.1.1.34, 1.1.1.88, 2.3.1.9 C Belongs to the HMG-CoA reductase family
CMALGNEG_01391 1e-25 K hmm pf08876
CMALGNEG_01392 1.1e-116 yqfA K protein, Hemolysin III
CMALGNEG_01393 1.6e-22 S Protein of unknown function (DUF3114)
CMALGNEG_01394 1.1e-161 S Protein of unknown function (DUF3114)
CMALGNEG_01395 1.6e-70 S hydrolases or acyltransferases (alpha beta hydrolase superfamily)
CMALGNEG_01396 2.3e-57 S hydrolases or acyltransferases (alpha beta hydrolase superfamily)
CMALGNEG_01397 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CMALGNEG_01398 5.5e-49 XK27_13030
CMALGNEG_01399 1.2e-247 mgs 2.4.1.337 GT4 M Glycosyltransferase, group 1 family protein
CMALGNEG_01400 4.4e-191 dgs 2.4.1.208 GT4 M Glycosyltransferase, group 1 family protein
CMALGNEG_01401 4.2e-68 U protein secretion
CMALGNEG_01402 3e-29 U protein secretion
CMALGNEG_01404 1.7e-117 mtnN 3.2.2.9 E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CMALGNEG_01405 2.5e-21
CMALGNEG_01406 1e-96 nudF 3.6.1.13 L AdP-ribose pyrophosphatase
CMALGNEG_01407 1.8e-251 glmU 2.3.1.157, 2.7.7.23 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CMALGNEG_01408 2.4e-184 fni 1.1.1.88, 5.3.3.2 C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
CMALGNEG_01409 1e-176 mvaK2 2.7.1.36, 2.7.1.43, 2.7.4.2 I GHMP kinases N terminal domain
CMALGNEG_01410 1.4e-170 mvaD 4.1.1.33 I diphosphomevalonate decarboxylase
CMALGNEG_01411 7.9e-136 mvk 1.1.1.88, 2.3.3.10, 2.7.1.36 I mevalonate kinase
CMALGNEG_01412 8.8e-104 GBS0088 J protein conserved in bacteria
CMALGNEG_01413 7.5e-247 merA 1.16.1.1 C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CMALGNEG_01414 1.3e-46 ald 1.4.1.1 C Belongs to the AlaDH PNT family
CMALGNEG_01415 3.4e-17 ald 1.4.1.1 E alanine dehydrogenase activity
CMALGNEG_01416 7e-217 hipO 3.5.1.47 E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
CMALGNEG_01417 4.8e-131 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
CMALGNEG_01418 2.5e-113 S VIT family
CMALGNEG_01419 6.5e-142 deoD_1 2.4.2.3 F Phosphorylase superfamily
CMALGNEG_01420 1.9e-22
CMALGNEG_01421 8e-28 XK27_00085 K Transcriptional
CMALGNEG_01422 6.9e-197 yceA S Belongs to the UPF0176 family
CMALGNEG_01423 5.4e-122 sagI S ABC-2 type transporter
CMALGNEG_01424 2.8e-168 V ABC transporter
CMALGNEG_01425 2.5e-219 2.7.7.73, 2.7.7.80 H Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
CMALGNEG_01426 2.5e-132 rr02 KT response regulator
CMALGNEG_01427 3.3e-215 2.7.13.3 T signal transduction protein with a C-terminal ATPase domain
CMALGNEG_01428 5e-125 nagB 3.1.1.31, 3.5.99.6 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
CMALGNEG_01429 1.3e-198 queA 2.4.99.17 J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CMALGNEG_01430 0.0 lmrA V abc transporter atp-binding protein
CMALGNEG_01431 0.0 mdlB V abc transporter atp-binding protein
CMALGNEG_01433 3.9e-52 rplL J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
CMALGNEG_01434 5.6e-78 rplJ J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CMALGNEG_01435 7.2e-24 ytrF V efflux transmembrane transporter activity
CMALGNEG_01436 4.6e-43 V efflux transmembrane transporter activity
CMALGNEG_01437 1.7e-59 V permease protein
CMALGNEG_01438 6.9e-37 acrA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CMALGNEG_01439 7.6e-21 acrA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CMALGNEG_01440 5.1e-131 2.1.1.223 S Putative SAM-dependent methyltransferase
CMALGNEG_01441 0.0 carB 6.3.5.5 F carbamoyl-phosphate synthetase ammonia chain
CMALGNEG_01442 5.5e-211 carA 6.3.5.5 F carbamoyl-phosphate synthetase glutamine chain
CMALGNEG_01443 1e-173 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
CMALGNEG_01444 3.7e-227 pyrP F uracil Permease
CMALGNEG_01445 3.7e-88 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CMALGNEG_01446 2.9e-162 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
CMALGNEG_01447 1.5e-77 lspA 3.4.23.36 MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CMALGNEG_01448 1.4e-167 fhuR K transcriptional regulator (lysR family)
CMALGNEG_01454 3.2e-141 ppiA 5.2.1.8 O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CMALGNEG_01455 1.4e-75 2.7.1.199, 2.7.1.211 G PTS glucose transporter subunit IIA
CMALGNEG_01456 9.4e-119 pts33BCA G pts system
CMALGNEG_01457 5.8e-71 pts33BCA G pts system
CMALGNEG_01458 4.8e-24 pts33BCA G pts system
CMALGNEG_01459 2.4e-09 uvrX 2.7.7.7 L impB/mucB/samB family
CMALGNEG_01460 1.8e-254 cycA E permease
CMALGNEG_01461 4.5e-39 ynzC S UPF0291 protein
CMALGNEG_01462 0.0 glyS 6.1.1.14 J Glycyl-tRNA synthetase beta subunit
CMALGNEG_01463 4.8e-176 glyQ 6.1.1.14 J glycyl-tRNA synthetase alpha subunit
CMALGNEG_01464 1.7e-32 S membrane
CMALGNEG_01465 1.2e-61
CMALGNEG_01466 4.4e-26
CMALGNEG_01467 7.4e-55
CMALGNEG_01468 4e-220 nagA 3.5.1.25 G Belongs to the metallo-dependent hydrolases superfamily. NagA family
CMALGNEG_01469 1.5e-114 nptA P COG1283 Na phosphate symporter
CMALGNEG_01470 2.9e-148 XK27_04800 S Sucrose-6F-phosphate phosphohydrolase
CMALGNEG_01471 9.2e-105 mur1 NU mannosyl-glycoprotein
CMALGNEG_01472 1.2e-52 glnB K Belongs to the P(II) protein family
CMALGNEG_01473 2.9e-232 amt P Ammonium Transporter
CMALGNEG_01474 4.6e-160 rsmI 2.1.1.198 H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CMALGNEG_01475 9.5e-55 yabA L Involved in initiation control of chromosome replication
CMALGNEG_01476 1.2e-135 yaaT S stage 0 sporulation protein
CMALGNEG_01477 6.4e-162 holB 2.7.7.7 L dna polymerase iii
CMALGNEG_01478 1.7e-111 tmk 2.7.4.9 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CMALGNEG_01479 1.4e-136 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
CMALGNEG_01480 9.5e-225 tuf J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CMALGNEG_01481 2.8e-230 ftsW D Belongs to the SEDS family
CMALGNEG_01482 5.2e-67 atpC C Produces ATP from ADP in the presence of a proton gradient across the membrane
CMALGNEG_01483 2.7e-263 atpD 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CMALGNEG_01484 2.5e-158 atpG C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CMALGNEG_01485 3.8e-279 atpA 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CMALGNEG_01486 3.5e-86 atpH C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CMALGNEG_01487 3.3e-78 atpF C ATP synthase F(0) sector subunit b
CMALGNEG_01488 2.4e-114 atpB C it plays a direct role in the translocation of protons across the membrane
CMALGNEG_01489 3.2e-16 atpE C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CMALGNEG_01490 1.1e-250 L Transposase
CMALGNEG_01491 0.0 valS 6.1.1.9 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
CMALGNEG_01492 5.9e-54 2.3.1.128, 5.2.1.8 J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CMALGNEG_01493 8e-51 S COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CMALGNEG_01494 8.9e-14 coiA 3.6.4.12 S Competence protein
CMALGNEG_01495 2.9e-15 T peptidase
CMALGNEG_01496 1.4e-151 rarD S Transporter
CMALGNEG_01497 6.3e-154 thrB 2.7.1.39 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
CMALGNEG_01498 2.3e-237 hom 1.1.1.3, 2.7.2.4 E homoserine dehydrogenase
CMALGNEG_01499 2.2e-130 yxkH G deacetylase
CMALGNEG_01500 1.4e-209 argD 2.6.1.11, 2.6.1.17 E acetylornithine aminotransferase
CMALGNEG_01501 7.9e-129 argB 2.7.2.8 E Belongs to the acetylglutamate kinase family. ArgB subfamily
CMALGNEG_01502 1.5e-222 argJ 2.3.1.1, 2.3.1.35, 2.7.2.8 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CMALGNEG_01503 1.4e-189 argC 1.2.1.38 E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CMALGNEG_01504 1.7e-226 mtnE 2.6.1.83 E mutations do not affect methionine salvage in vivo however
CMALGNEG_01505 4.9e-145 cnhA 3.5.1.3 S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
CMALGNEG_01506 3.9e-120 3.4.17.14, 3.5.1.28 NU amidase activity
CMALGNEG_01507 6.9e-179 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
CMALGNEG_01508 7.9e-24 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
CMALGNEG_01509 0.0 alaS 6.1.1.7 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CMALGNEG_01510 1.3e-167 prsA 3.1.3.16, 5.2.1.8 O peptidyl-prolyl cis-trans isomerase activity
CMALGNEG_01511 5.4e-127 yrrM 2.1.1.104 S O-Methyltransferase
CMALGNEG_01512 0.0 pepF E oligoendopeptidase F
CMALGNEG_01513 1.4e-186 coiA 3.6.4.12 S Competence protein
CMALGNEG_01514 1.8e-164 K transcriptional regulator (lysR family)
CMALGNEG_01515 0.0 metG 6.1.1.10, 6.1.1.20 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CMALGNEG_01519 8e-191 phoH T phosphate starvation-inducible protein PhoH
CMALGNEG_01520 2.3e-61 rlpA M LysM domain protein
CMALGNEG_01521 1.5e-123 usp 3.5.1.104, 3.5.1.28 CBM50 S pathogenesis
CMALGNEG_01522 7.4e-35 yozE S Belongs to the UPF0346 family
CMALGNEG_01523 1.7e-159 cvfB S Protein conserved in bacteria
CMALGNEG_01524 9.9e-92 frr J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
CMALGNEG_01525 4.9e-131 pyrH 2.7.4.22 F Catalyzes the reversible phosphorylation of UMP to UDP
CMALGNEG_01526 1.3e-120 sptS 2.7.13.3 T Histidine kinase
CMALGNEG_01527 1.4e-45 K Acetyltransferase (GNAT) family
CMALGNEG_01528 0.0 lmrA2 V abc transporter atp-binding protein
CMALGNEG_01529 0.0 lmrA1 V abc transporter atp-binding protein
CMALGNEG_01530 1.9e-77 K DNA-binding transcription factor activity
CMALGNEG_01531 1e-69 def_1 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins
CMALGNEG_01532 1.8e-256 gdhA 1.4.1.4 E Belongs to the Glu Leu Phe Val dehydrogenases family
CMALGNEG_01533 1.7e-212 nadD 2.7.1.22, 2.7.7.1, 2.7.7.18, 3.6.1.55 H adenylyltransferase
CMALGNEG_01534 6.5e-77 3.6.1.13, 3.6.1.55 F AdP-ribose pyrophosphatase
CMALGNEG_01535 7.2e-25 U response to pH
CMALGNEG_01536 0.0 yfmR S abc transporter atp-binding protein
CMALGNEG_01537 9.6e-225 cca 2.7.7.19, 2.7.7.72 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
CMALGNEG_01538 3e-139 dapB 1.17.1.8 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
CMALGNEG_01539 9.8e-91 XK27_08360 S EDD domain protein, DegV family
CMALGNEG_01540 2.6e-64 WQ51_03320 S cog cog4835
CMALGNEG_01541 7.7e-134 ydaF_2 J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CMALGNEG_01542 1.5e-46 rpmA J Belongs to the bacterial ribosomal protein bL27 family
CMALGNEG_01543 4.5e-49 rplU J This protein binds to 23S rRNA in the presence of protein L20
CMALGNEG_01544 6.4e-29 2.3.1.128 K acetyltransferase
CMALGNEG_01545 7.2e-258 gtf2 M A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1
CMALGNEG_01546 4.9e-295 gtf1 2.4.1.52 GT4 M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
CMALGNEG_01547 6.5e-229 thiI 2.8.1.4 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CMALGNEG_01548 6.1e-213 iscS2 2.8.1.7 E Cysteine sulfinate desulfinase cysteine desulfurase and related enzymes
CMALGNEG_01550 2.6e-241 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
CMALGNEG_01551 2.7e-260 gor 1.8.1.7 C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CMALGNEG_01552 0.0 fruA 2.7.1.202 G phosphotransferase system
CMALGNEG_01553 3.8e-165 pfkB 2.7.1.11, 2.7.1.56 H Belongs to the carbohydrate kinase PfkB family. LacC subfamily
CMALGNEG_01554 5.5e-122 fruR K transcriptional
CMALGNEG_01555 8.9e-84 L Transposase
CMALGNEG_01556 1.3e-205 rny D Endoribonuclease that initiates mRNA decay
CMALGNEG_01557 6.6e-38 L transposase activity
CMALGNEG_01558 8.4e-155 L COG2801 Transposase and inactivated derivatives
CMALGNEG_01559 1.1e-113 K sequence-specific DNA binding
CMALGNEG_01560 6.4e-85 C Arylsulfatase regulator (Fe-S oxidoreductase)
CMALGNEG_01561 1.4e-74 C Arylsulfatase regulator (Fe-S oxidoreductase)
CMALGNEG_01562 7.7e-198 V (ABC) transporter
CMALGNEG_01563 1.7e-51 2.3.1.128 K Acetyltransferase GNAT Family
CMALGNEG_01564 1.1e-176 S Protein of unknown function (DUF3114)
CMALGNEG_01565 2.7e-82 S Protein of unknown function (DUF3114)
CMALGNEG_01567 1.1e-65 tnp L Transposase
CMALGNEG_01568 4.7e-27 L Transposase and inactivated derivatives, TnpA family
CMALGNEG_01569 9.8e-176 gadC E Psort location CytoplasmicMembrane, score 10.00
CMALGNEG_01570 2.3e-214 gadB 4.1.1.15 E Belongs to the group II decarboxylase family
CMALGNEG_01571 1.1e-65 tnp L Transposase
CMALGNEG_01572 4.7e-90 luxS 4.4.1.21 H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
CMALGNEG_01573 1.1e-138 accA 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
CMALGNEG_01574 1.6e-160 accD 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CMALGNEG_01575 1.7e-257 accC 6.3.4.14, 6.4.1.2 I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
CMALGNEG_01576 1.5e-71 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
CMALGNEG_01577 7.7e-56 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
CMALGNEG_01578 2.6e-233 fabF 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
CMALGNEG_01579 1.6e-126 IQ reductase
CMALGNEG_01580 8.5e-165 fabD 2.3.1.39 I Malonyl CoA-acyl carrier protein transacylase
CMALGNEG_01581 1.2e-172 fabK 1.3.1.9 S 2-Nitropropane dioxygenase
CMALGNEG_01582 3.3e-30 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
CMALGNEG_01583 2.3e-173 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CMALGNEG_01584 4e-72 marR K Transcriptional regulator, MarR family
CMALGNEG_01585 6.9e-139 phaB 5.3.3.14, 5.3.3.18 I Belongs to the enoyl-CoA hydratase isomerase family
CMALGNEG_01586 1.6e-114 S Haloacid dehalogenase-like hydrolase
CMALGNEG_01587 2.4e-256 lysC 2.7.2.4 E Belongs to the aspartokinase family
CMALGNEG_01588 8e-193 asnA 6.3.1.1 E aspartate--ammonia ligase
CMALGNEG_01589 6.7e-259 rumA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CMALGNEG_01590 1.2e-130 recX 2.4.1.337 GT4 S Regulatory protein RecX
CMALGNEG_01591 1.3e-101 ygaC J Belongs to the UPF0374 family
CMALGNEG_01592 6.4e-108 S Domain of unknown function (DUF1803)
CMALGNEG_01593 3.5e-166 ppaC 3.6.1.1 C inorganic pyrophosphatase
CMALGNEG_01601 3e-11
CMALGNEG_01602 2.1e-94 hpf J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CMALGNEG_01603 1.7e-122 comFC S Competence protein
CMALGNEG_01604 5.9e-252 comFA L Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CMALGNEG_01605 1.1e-110 yvyE 3.4.13.9 S YigZ family
CMALGNEG_01606 3.7e-168 cysK 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
CMALGNEG_01607 8.9e-41 acuB S IMP dehydrogenase activity
CMALGNEG_01608 6.8e-69 acuB S IMP dehydrogenase activity
CMALGNEG_01609 4.8e-123 livF E COG0410 ABC-type branched-chain amino acid transport systems, ATPase component
CMALGNEG_01610 9.6e-138 livG E COG0411 ABC-type branched-chain amino acid transport systems, ATPase component
CMALGNEG_01611 1.4e-138 livM E Belongs to the binding-protein-dependent transport system permease family
CMALGNEG_01612 1.9e-145 livH E Belongs to the binding-protein-dependent transport system permease family
CMALGNEG_01613 1.3e-210 livJ E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component
CMALGNEG_01614 7.1e-46 ylbG S UPF0298 protein
CMALGNEG_01615 1.2e-74 ylbF S Belongs to the UPF0342 family
CMALGNEG_01616 2.9e-105 clpP 3.4.21.92 OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
CMALGNEG_01617 4.4e-112 upp 2.4.2.9 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CMALGNEG_01619 1e-223 malY 4.4.1.8 E COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
CMALGNEG_01620 4.7e-202 metB 2.5.1.48, 4.4.1.8 E cystathionine
CMALGNEG_01621 3.3e-96 pacL 3.6.3.8, 3.6.3.9 P cation transport ATPase
CMALGNEG_01622 4.5e-283 ytgP S Membrane protein involved in the export of O-antigen and teichoic acid
CMALGNEG_01623 4.9e-276 murE 6.3.2.13, 6.3.2.7 M to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CMALGNEG_01624 6e-157 femA 2.3.2.10, 2.3.2.16, 2.3.2.17, 2.3.2.18 V protein involved in methicillin resistance
CMALGNEG_01625 3.6e-48 femA 2.3.2.10, 2.3.2.16, 2.3.2.17, 2.3.2.18 V protein involved in methicillin resistance
CMALGNEG_01626 1.5e-25 yvdD 3.2.2.10 S cytokinin biosynthetic process
CMALGNEG_01627 2e-22 yvdD 3.2.2.10 S Belongs to the LOG family
CMALGNEG_01628 1.7e-57 rbfA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CMALGNEG_01629 0.0 infB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CMALGNEG_01630 1.4e-41 ylxQ J ribosomal protein
CMALGNEG_01631 1e-47 ylxR K Nucleic-acid-binding protein implicated in transcription termination
CMALGNEG_01632 3.1e-212 nusA K Participates in both transcription termination and antitermination
CMALGNEG_01633 3.9e-81 rimP S Required for maturation of 30S ribosomal subunits
CMALGNEG_01634 2.5e-220 brpA K Transcriptional
CMALGNEG_01635 2.4e-92 XK27_05885 2.3.1.82 M Acetyltransferase GNAT Family
CMALGNEG_01636 1.4e-77 ydiB 2.7.1.221, 5.1.1.1 M ATPase or kinase
CMALGNEG_01637 2.5e-248 pbuO S permease
CMALGNEG_01638 1e-153 yitU 3.1.3.104 S hydrolases of the HAD superfamily
CMALGNEG_01639 1.5e-140 XK27_00940 1.2.1.70, 3.5.1.9 S Metal-dependent hydrolase
CMALGNEG_01640 1.1e-181 manL 2.7.1.191 G pts system
CMALGNEG_01641 5e-108 manM G pts system
CMALGNEG_01642 1.1e-169 manN G PTS system mannose fructose sorbose family IID component
CMALGNEG_01643 4.2e-62 manO S protein conserved in bacteria
CMALGNEG_01644 8e-230 serS 6.1.1.11 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CMALGNEG_01645 1.3e-221 L Transposase
CMALGNEG_01646 2.6e-94 L Integrase core domain
CMALGNEG_01647 1.4e-36 L Integrase core domain
CMALGNEG_01648 1.8e-165 M domain protein
CMALGNEG_01649 0.0 M domain protein
CMALGNEG_01650 2.1e-12 G gluconolactonase activity
CMALGNEG_01651 1.3e-125 tnp L DDE domain
CMALGNEG_01652 9.5e-17 lytN 3.5.1.104 M LysM domain
CMALGNEG_01653 2.8e-160 L Transposase DDE domain
CMALGNEG_01654 4.3e-41 L Protein of unknown function (DUF3991)
CMALGNEG_01656 6.9e-150 L Transposase
CMALGNEG_01657 7.6e-55 L Transposase
CMALGNEG_01658 2.3e-42 L transposase activity
CMALGNEG_01659 5e-23 L Transposase
CMALGNEG_01660 1.7e-54 L transposition
CMALGNEG_01661 3.4e-80 L PFAM Integrase catalytic region
CMALGNEG_01662 9e-88 yrdC 3.5.1.19 Q isochorismatase
CMALGNEG_01663 1.3e-246 der 1.1.1.399, 1.1.1.95 S GTPase that plays an essential role in the late steps of ribosome biogenesis
CMALGNEG_01664 4e-167 dnaI L Primosomal protein DnaI
CMALGNEG_01665 5e-218 dnaB L Replication initiation and membrane attachment
CMALGNEG_01666 2.8e-82 nrdR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CMALGNEG_01667 3.3e-275 T PhoQ Sensor
CMALGNEG_01668 1.8e-122 T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
CMALGNEG_01669 2.1e-91 yceD K metal-binding, possibly nucleic acid-binding protein
CMALGNEG_01670 1.1e-130 rsmG 2.1.1.170 J Ribosomal RNA small subunit methyltransferase G
CMALGNEG_01671 1.4e-243 P COG0168 Trk-type K transport systems, membrane components
CMALGNEG_01672 1.4e-121 ktrA P COG0569 K transport systems, NAD-binding component
CMALGNEG_01673 1.4e-11 ulaG S L-ascorbate 6-phosphate lactonase
CMALGNEG_01674 0.0 tkt 2.2.1.1 G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CMALGNEG_01675 1.2e-146 cbiQ P cobalt transport
CMALGNEG_01676 0.0 ykoD P abc transporter atp-binding protein
CMALGNEG_01677 8e-94 S UPF0397 protein
CMALGNEG_01678 5.5e-158 salL 2.5.1.63, 2.5.1.94 S S-adenosyl-l-methionine hydroxide adenosyltransferase
CMALGNEG_01679 3.9e-210 sstT E Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CMALGNEG_01680 5.2e-98 metI P ABC transporter (Permease
CMALGNEG_01681 1.2e-189 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CMALGNEG_01682 1.4e-62 dapE 3.5.1.18 E succinyl-diaminopimelate desuccinylase activity
CMALGNEG_01683 1.2e-61 dapE 3.5.1.18 E succinyl-diaminopimelate desuccinylase activity
CMALGNEG_01684 4.9e-87 dapE 3.5.1.18 E COG0624, acetylornithine deacetylase succinyl-diaminopimelate desuccinylase and related deacylases
CMALGNEG_01685 7.1e-164 metQ M Belongs to the NlpA lipoprotein family
CMALGNEG_01686 1.8e-153 ET amino acid transport
CMALGNEG_01687 3.8e-205 EGP Transmembrane secretion effector
CMALGNEG_01688 0.0 3.3.1.1, 3.6.1.55, 3.6.1.67 F NUDIX domain
CMALGNEG_01689 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
CMALGNEG_01690 5.3e-153 ET amino acid transport
CMALGNEG_01691 1.6e-131 cbiO P ABC transporter
CMALGNEG_01692 1.1e-136 P cobalt transport protein
CMALGNEG_01693 4.3e-175 cbiM P PDGLE domain
CMALGNEG_01694 3.4e-160 ureD O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
CMALGNEG_01695 9.5e-112 ureG KO Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CMALGNEG_01696 5.3e-130 ureF O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
CMALGNEG_01697 6.6e-78 ureE O enzyme active site formation
CMALGNEG_01698 0.0 ureC 3.5.1.5 E Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family
CMALGNEG_01699 7.8e-54 ureB 3.5.1.5 E Belongs to the urease beta subunit family
CMALGNEG_01700 7.6e-46 ureA 3.5.1.5 E Belongs to the urease gamma subunit family
CMALGNEG_01701 6.8e-95 ureI S AmiS/UreI family transporter
CMALGNEG_01702 5e-84 S Domain of unknown function (DUF4173)
CMALGNEG_01703 1.8e-50 yhaI L Membrane
CMALGNEG_01704 2.3e-129 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
CMALGNEG_01705 1.8e-34 V protein secretion by the type I secretion system
CMALGNEG_01706 1.2e-54 V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
CMALGNEG_01707 7.4e-36 V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
CMALGNEG_01708 1.2e-32 V protein secretion by the type I secretion system
CMALGNEG_01709 5.6e-161 K sequence-specific DNA binding
CMALGNEG_01710 4.8e-114 bcrC 3.6.1.27 I Membrane-associated phospholipid phosphatase
CMALGNEG_01711 3.2e-90 ribU U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CMALGNEG_01712 7.9e-96 trmL 2.1.1.207 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
CMALGNEG_01713 1.3e-246 trkA P Potassium transporter peripheral membrane component
CMALGNEG_01714 1.2e-258 trkH P Cation transport protein
CMALGNEG_01715 1.2e-39 yidD S Could be involved in insertion of integral membrane proteins into the membrane
CMALGNEG_01716 6.1e-140 rluB 5.4.99.19, 5.4.99.21, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
CMALGNEG_01717 3e-99 scpB D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CMALGNEG_01718 3.8e-120 scpA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CMALGNEG_01719 4.5e-135 xerD L tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site
CMALGNEG_01720 7.8e-85 ykuL S CBS domain
CMALGNEG_01721 3.5e-99 XK27_09740 S Phosphoesterase
CMALGNEG_01722 7.1e-186 rdgB 3.6.1.66, 5.1.1.3 F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CMALGNEG_01723 3.8e-148 murI 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
CMALGNEG_01724 7.6e-36 yneF S UPF0154 protein
CMALGNEG_01725 3.7e-91 K transcriptional regulator
CMALGNEG_01726 9.6e-244 lysA 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
CMALGNEG_01729 8.8e-98 ybhL S Belongs to the BI1 family
CMALGNEG_01730 6.1e-93 XK27_09705 6.1.1.14 S HD superfamily hydrolase
CMALGNEG_01731 6.4e-131 spoU 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CMALGNEG_01732 7e-46 acyP 3.6.1.7 C Belongs to the acylphosphatase family
CMALGNEG_01733 8.5e-165 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
CMALGNEG_01734 5.2e-59 L Integrase core domain protein
CMALGNEG_01735 1.6e-77 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
CMALGNEG_01736 0.0 mltG ADL Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CMALGNEG_01737 2.1e-82 XK27_09675 K -acetyltransferase
CMALGNEG_01738 5.7e-255 mpl 6.3.2.4, 6.3.2.45, 6.3.2.8 M Belongs to the MurCDEF family
CMALGNEG_01739 2.5e-23
CMALGNEG_01740 0.0 snf 2.7.11.1 L Superfamily II DNA RNA helicases, SNF2 family'
CMALGNEG_01741 2.5e-296 mapZ D Early cell division protein that marks the future cell division site and supports proper FtsZ ring positioning
CMALGNEG_01742 1.5e-222 rlmL 2.1.1.173, 2.1.1.264 L Belongs to the methyltransferase superfamily
CMALGNEG_01743 5.6e-50 gpsB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
CMALGNEG_01744 8.9e-95 ypsA S Belongs to the UPF0398 family
CMALGNEG_01745 2.5e-109 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
CMALGNEG_01746 0.0 ponA 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
CMALGNEG_01747 1.6e-249 L Transposase
CMALGNEG_01748 5.1e-259 pepC 3.4.22.40 E aminopeptidase
CMALGNEG_01749 1.9e-77 yhaI L Membrane
CMALGNEG_01750 2.1e-151 nadE 6.3.1.5 H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
CMALGNEG_01751 1.3e-279 pncB 6.3.4.21 H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CMALGNEG_01752 1e-139 S COG1073 Hydrolases of the alpha beta superfamily
CMALGNEG_01753 2.6e-76 S thiolester hydrolase activity
CMALGNEG_01755 3.8e-40 K transcriptional
CMALGNEG_01757 0.0 leuS 6.1.1.4 J Belongs to the class-I aminoacyl-tRNA synthetase family
CMALGNEG_01758 1.6e-137 glcR K transcriptional regulator (DeoR family)
CMALGNEG_01759 6.2e-35 cof Q phosphatase activity
CMALGNEG_01760 6e-55 cof Q phosphatase activity
CMALGNEG_01761 4.6e-85 3.1.3.27, 3.1.3.4, 3.1.3.81, 3.6.1.27 I phosphatidate phosphatase activity
CMALGNEG_01762 8.4e-96 nusG K Participates in transcription elongation, termination and antitermination
CMALGNEG_01763 5.7e-25 secE U Belongs to the SecE SEC61-gamma family
CMALGNEG_01764 3.3e-21 rpmG J Belongs to the bacterial ribosomal protein bL33 family
CMALGNEG_01765 0.0 pbp2A 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
CMALGNEG_01766 1.2e-165 rluA 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
CMALGNEG_01767 6.8e-56 S TM2 domain
CMALGNEG_01768 4.7e-43
CMALGNEG_01770 1.4e-33 L Integrase core domain protein
CMALGNEG_01771 1.7e-51 L transposition
CMALGNEG_01772 3.2e-10 L transposase activity
CMALGNEG_01773 4.4e-37 L Transposase
CMALGNEG_01774 4.1e-287 groL O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
CMALGNEG_01775 1.3e-42 groS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CMALGNEG_01776 5.2e-142 cmpC S abc transporter atp-binding protein
CMALGNEG_01777 0.0 WQ51_06230 S ABC transporter substrate binding protein
CMALGNEG_01778 0.0 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
CMALGNEG_01779 1.4e-231 rseP 3.4.21.107, 3.4.21.116 M zinc metalloprotease
CMALGNEG_01780 2.2e-145 cdsA 2.7.7.41 S Belongs to the CDS family
CMALGNEG_01781 1.1e-141 uppS 2.5.1.31 H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CMALGNEG_01782 9.8e-50 yajC U protein transport
CMALGNEG_01783 1.9e-127 yeeN K transcriptional regulatory protein
CMALGNEG_01784 1.1e-256 pgi 5.3.1.9 G Belongs to the GPI family
CMALGNEG_01785 6.6e-150 rgfB 3.1.3.90 L endonuclease exonuclease phosphatase family protein
CMALGNEG_01786 4.8e-106 ptsG 2.7.1.199, 2.7.1.208, 2.7.1.211 G phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1
CMALGNEG_01787 2.1e-150 ptsG 2.7.1.199, 2.7.1.208, 2.7.1.211 G pts system
CMALGNEG_01788 5.6e-65 ptsG 2.7.1.199, 2.7.1.208 G pts system
CMALGNEG_01789 1.4e-162 mleP2 S Transporter, auxin efflux carrier (AEC) family protein
CMALGNEG_01790 1.6e-127 adcB P ABC transporter (Permease
CMALGNEG_01791 8.3e-136 adcC P ABC transporter, ATP-binding protein
CMALGNEG_01792 3.1e-72 adcR K transcriptional
CMALGNEG_01793 9.4e-223 EGP Major facilitator Superfamily
CMALGNEG_01794 7.4e-183 dus J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CMALGNEG_01795 1.1e-161 hslO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CMALGNEG_01796 6.4e-23
CMALGNEG_01797 3.4e-62 oppF P Belongs to the ABC transporter superfamily
CMALGNEG_01798 7.5e-62 oppF P Belongs to the ABC transporter superfamily
CMALGNEG_01799 2.7e-41 oppD P Belongs to the ABC transporter superfamily
CMALGNEG_01800 1.2e-62 oppD P Belongs to the ABC transporter superfamily
CMALGNEG_01801 2.5e-32 oppD P Belongs to the ABC transporter superfamily
CMALGNEG_01802 3e-27 oppD P Belongs to the ABC transporter superfamily
CMALGNEG_01803 1.4e-38 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
CMALGNEG_01804 1.7e-33 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
CMALGNEG_01805 6.6e-11 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
CMALGNEG_01806 4.2e-27 oppB P ABC-type dipeptide oligopeptide nickel transport systems, permease components
CMALGNEG_01807 2e-138 oppA E ABC transporter substrate-binding protein
CMALGNEG_01808 7e-10 oppA E ABC transporter substrate-binding protein
CMALGNEG_01809 2.2e-273 sufB O assembly protein SufB
CMALGNEG_01810 2.5e-74 nifU C SUF system FeS assembly protein, NifU family
CMALGNEG_01811 7.7e-238 sufS 2.8.1.7, 4.4.1.16 E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CMALGNEG_01812 6.3e-235 sufD O assembly protein SufD
CMALGNEG_01813 9.5e-144 sufC O ABC-type transport system involved in Fe-S cluster assembly, ATPase component
CMALGNEG_01814 5.5e-185 tagO 2.7.8.33, 2.7.8.35 M transferase
CMALGNEG_01815 5.2e-136 mecA NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
CMALGNEG_01816 3.1e-153 uppP 3.6.1.27 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
CMALGNEG_01817 5.8e-275 glnP P ABC transporter
CMALGNEG_01818 1e-123 glnQ E abc transporter atp-binding protein
CMALGNEG_01819 5e-94 V VanZ like family
CMALGNEG_01820 9.2e-43 rpsO J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CMALGNEG_01821 6.5e-202 yhjX P Major Facilitator
CMALGNEG_01822 5.3e-113 fnr5 K Catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
CMALGNEG_01823 3.3e-112 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
CMALGNEG_01824 1.7e-237 ilvA 4.3.1.19 E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CMALGNEG_01825 3.9e-46 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
CMALGNEG_01826 2.1e-58 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
CMALGNEG_01827 2e-27 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
CMALGNEG_01828 1.4e-09 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
CMALGNEG_01829 3.3e-74 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
CMALGNEG_01830 0.0 relA 2.7.6.5 KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CMALGNEG_01831 3.8e-81 nrdI F Belongs to the NrdI family
CMALGNEG_01832 6.3e-186 cpdB 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
CMALGNEG_01833 5.4e-139 cpdB 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
CMALGNEG_01834 1.4e-42 F nucleotide catabolic process
CMALGNEG_01835 4.4e-135 rsmE 2.1.1.193 J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
CMALGNEG_01836 2e-177 prmA J Ribosomal protein L11 methyltransferase
CMALGNEG_01837 3.7e-81 mutT3 3.6.1.13, 3.6.1.55 L NUDIX domain
CMALGNEG_01838 1.1e-83 XK27_03960 S Protein of unknown function (DUF3013)
CMALGNEG_01839 7.6e-310 pyrG 6.3.4.2 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
CMALGNEG_01840 4.8e-73 rpoE K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
CMALGNEG_01841 6.4e-219 tig D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
CMALGNEG_01842 4.6e-149 ykuT M mechanosensitive ion channel
CMALGNEG_01843 1.6e-77 sigH K DNA-templated transcription, initiation
CMALGNEG_01844 6.5e-87
CMALGNEG_01845 1.5e-233 cfa 2.1.1.317, 2.1.1.79 M cyclopropane-fatty-acyl-phospholipid synthase
CMALGNEG_01846 1.8e-56 amd 3.5.1.47 E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
CMALGNEG_01847 9.9e-19 S Domain of unknown function (DUF4649)
CMALGNEG_01848 2.5e-169 L Transposase
CMALGNEG_01849 0.0 amiA E ABC transporter, substrate-binding protein, family 5
CMALGNEG_01852 2.5e-10
CMALGNEG_01863 1.7e-60 hmpT S membrane
CMALGNEG_01864 6.2e-137 thiD 2.7.1.35, 2.7.1.49, 2.7.4.7 H phosphomethylpyrimidine kinase
CMALGNEG_01865 2.5e-138 truA 5.4.99.12 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
CMALGNEG_01866 4.2e-190 dnaJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
CMALGNEG_01867 9.8e-298 dnaK O Heat shock 70 kDa protein
CMALGNEG_01868 1.3e-71 grpE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CMALGNEG_01869 5.3e-198 hrcA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
CMALGNEG_01870 1.3e-102 acmA 3.2.1.17 NU amidase activity
CMALGNEG_01871 1.6e-143 vanY 3.4.17.14 M D-alanyl-D-alanine carboxypeptidase
CMALGNEG_01872 2.2e-38 ais G alpha-ribazole phosphatase activity
CMALGNEG_01873 1.9e-242 XK27_08635 S UPF0210 protein
CMALGNEG_01874 3.6e-39 gcvR T UPF0237 protein
CMALGNEG_01875 3.3e-225 capA M Bacterial capsule synthesis protein
CMALGNEG_01876 5.7e-91 tnp L Transposase
CMALGNEG_01877 3.4e-75 isp2 S pathogenesis
CMALGNEG_01879 4.9e-173
CMALGNEG_01880 1.8e-38 S Helix-turn-helix domain
CMALGNEG_01881 2.2e-224 int L Belongs to the 'phage' integrase family
CMALGNEG_01883 0.0 res_1 3.1.21.5 S Type III restriction
CMALGNEG_01884 9.7e-227 sthIM 2.1.1.72 L DNA methylase
CMALGNEG_01887 5.3e-18 D FtsK/SpoIIIE family
CMALGNEG_01888 1.3e-134 D ftsk spoiiie
CMALGNEG_01890 1.3e-154
CMALGNEG_01891 1.7e-22
CMALGNEG_01892 9.3e-184 L Phage integrase family
CMALGNEG_01893 6.5e-90 3.6.4.12 K Divergent AAA domain protein
CMALGNEG_01894 5.9e-24 3.6.4.12
CMALGNEG_01895 2.5e-183 EGP Major facilitator Superfamily
CMALGNEG_01896 2.4e-231 spaC2 V Lanthionine synthetase C family protein
CMALGNEG_01897 0.0 S Lantibiotic dehydratase, C terminus
CMALGNEG_01899 1.5e-35 K sequence-specific DNA binding
CMALGNEG_01900 9.5e-65 rpsI J Belongs to the universal ribosomal protein uS9 family
CMALGNEG_01901 2e-79 rplM J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CMALGNEG_01902 3.6e-57 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CMALGNEG_01903 1.6e-94 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CMALGNEG_01904 2.3e-31 K helix-turn-helix
CMALGNEG_01906 3.4e-155 degV S DegV family
CMALGNEG_01907 3.5e-91 yacP S RNA-binding protein containing a PIN domain
CMALGNEG_01908 5.7e-135 trmH 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CMALGNEG_01911 4.2e-68 mrnC J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CMALGNEG_01912 1.7e-259 cysS 6.1.1.16, 6.3.1.13 J Belongs to the class-I aminoacyl-tRNA synthetase family
CMALGNEG_01913 1.1e-112 cysE 2.3.1.30 E serine acetyltransferase
CMALGNEG_01914 4.5e-143 S SseB protein N-terminal domain
CMALGNEG_01915 0.0 pnp 2.7.7.8 J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
CMALGNEG_01916 1.2e-230 dacA 3.4.16.4 M Belongs to the peptidase S11 family
CMALGNEG_01917 4.4e-53 dacA 3.4.16.4 M Belongs to the peptidase S11 family
CMALGNEG_01918 9.1e-127 dacA 3.4.16.4 M Belongs to the peptidase S11 family
CMALGNEG_01919 0.0 clpC O Belongs to the ClpA ClpB family
CMALGNEG_01920 2.4e-75 ctsR K Belongs to the CtsR family
CMALGNEG_01921 1.1e-83 S Putative small multi-drug export protein
CMALGNEG_01922 1.7e-182 tsf J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CMALGNEG_01923 6.3e-137 rpsB J Belongs to the universal ribosomal protein uS2 family
CMALGNEG_01926 1.9e-86 yocD 3.4.17.13 V proteins, homologs of microcin C7 resistance protein MccF
CMALGNEG_01927 7.3e-22 yocD 3.4.17.13 V carboxypeptidase activity
CMALGNEG_01928 3.2e-40 L transposition
CMALGNEG_01929 1e-87 L Integrase core domain protein
CMALGNEG_01930 1.7e-96 S reductase
CMALGNEG_01931 1.8e-26 badR K DNA-binding transcription factor activity
CMALGNEG_01932 5.5e-36 XK27_02060 S Transglycosylase associated protein
CMALGNEG_01933 5.7e-222 pepS E COG2309 Leucyl aminopeptidase (aminopeptidase T)
CMALGNEG_01934 0.0 polC 2.7.7.7 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CMALGNEG_01939 1.9e-07
CMALGNEG_01942 2.6e-10
CMALGNEG_01948 1.2e-12
CMALGNEG_01949 1.1e-65 spxA_2 1.20.4.1 P Belongs to the ArsC family
CMALGNEG_01950 2e-195 recA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CMALGNEG_01951 1e-232 cinA 3.5.1.42 S Belongs to the CinA family
CMALGNEG_01952 6.4e-107 tag 3.2.2.20 L 3-methyladenine DNA glycosylase
CMALGNEG_01953 7.8e-103 ruvA 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
CMALGNEG_01954 3.9e-122 L Transposase
CMALGNEG_01955 5.5e-135 L integrase core domain
CMALGNEG_01957 0.0 mutL L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CMALGNEG_01959 1.2e-61 KT phosphorelay signal transduction system
CMALGNEG_01960 7e-34 S Protein of unknown function (DUF3021)
CMALGNEG_01961 0.0 mutS L that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CMALGNEG_01962 1e-57 ymcA 3.6.3.21 S Belongs to the UPF0342 family
CMALGNEG_01963 8.2e-70 argR K Regulates arginine biosynthesis genes
CMALGNEG_01964 2.6e-09 L Transposase
CMALGNEG_01965 0.0 argS 6.1.1.19 J Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
CMALGNEG_01966 8.7e-248 purB 4.3.2.2 F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CMALGNEG_01967 9.2e-141 1.1.1.169 H Ketopantoate reductase
CMALGNEG_01968 2.2e-204 purK 6.3.4.18 F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CMALGNEG_01969 4.9e-76 purE 5.4.99.18 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CMALGNEG_01970 3.4e-241 purD 6.3.4.13 F Belongs to the GARS family
CMALGNEG_01971 2.3e-161 S CHAP domain
CMALGNEG_01972 1.4e-33 L Integrase core domain protein
CMALGNEG_01973 1.4e-48 L transposition
CMALGNEG_01974 4.8e-76 L transposase activity
CMALGNEG_01975 1.2e-293 purH 2.1.2.3, 3.5.4.10 F Bifunctional purine biosynthesis protein PurH
CMALGNEG_01976 1.4e-101 purN 2.1.2.2 F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CMALGNEG_01977 1.8e-184 purM 6.3.3.1, 6.3.4.13 F Phosphoribosylformylglycinamidine cyclo-ligase
CMALGNEG_01978 1.3e-276 purF 2.4.2.14 F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CMALGNEG_01979 0.0 purL 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CMALGNEG_01980 2e-129 purC 4.1.1.21, 4.3.2.2, 6.3.2.6 F Belongs to the SAICAR synthetase family
CMALGNEG_01981 4.2e-34 acpP1 IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
CMALGNEG_01982 1.3e-179 plsX 2.3.1.15 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
CMALGNEG_01983 7e-124 recO L Involved in DNA repair and RecF pathway recombination
CMALGNEG_01984 2.9e-218 araT 2.6.1.1 E Aminotransferase
CMALGNEG_01985 1.2e-174 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CMALGNEG_01986 1.7e-90 usp 3.5.1.28 CBM50 S CHAP domain
CMALGNEG_01987 6.3e-88 mreD M Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CMALGNEG_01988 5.5e-139 mreC M Involved in formation and maintenance of cell shape
CMALGNEG_01994 5.3e-11
CMALGNEG_02007 1.9e-86 L Integrase core domain protein
CMALGNEG_02008 1.6e-55 L transposition
CMALGNEG_02009 1.1e-92 L Transposase
CMALGNEG_02010 1.3e-137 L Transposase
CMALGNEG_02011 0.0 ftsH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CMALGNEG_02012 3.4e-97 hpt 2.4.2.8, 6.3.4.19 F Belongs to the purine pyrimidine phosphoribosyltransferase family
CMALGNEG_02013 5e-240 tilS 2.4.2.8, 6.3.4.19 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
CMALGNEG_02014 1.3e-240 XK27_09285 3.5.2.6 V Beta-lactamase enzyme family
CMALGNEG_02016 2.7e-61 divIC D Septum formation initiator
CMALGNEG_02017 1.7e-39 yabO J Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
CMALGNEG_02018 0.0 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CMALGNEG_02019 1.4e-104 pth 3.1.1.29 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
CMALGNEG_02020 1.1e-203 ychF J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
CMALGNEG_02021 1.1e-29 yyzM S Protein conserved in bacteria
CMALGNEG_02022 6.3e-202 dnaN 2.7.7.7 L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
CMALGNEG_02024 4.3e-26 3.1.21.4 L Recognizes the double-stranded unmethylated sequence GATC and cleaves before G-1
CMALGNEG_02030 3e-53
CMALGNEG_02031 5.7e-132 L Replication protein
CMALGNEG_02032 3.6e-96 dam 2.1.1.72 L Site-specific DNA-methyltransferase (Adenine-specific)
CMALGNEG_02033 9.1e-143 3.1.21.4 L Recognizes the double-stranded unmethylated sequence GATC and cleaves before G-1

eggNOG-mapper v2 (Database: eggNOG v5.0, Jul. 2018 release)