ORF_ID e_value Gene_name EC_number CAZy COGs Description
AAKFIGLK_00001 0.0 V abc transporter atp-binding protein
AAKFIGLK_00002 1.4e-296 V abc transporter atp-binding protein
AAKFIGLK_00003 0.0 gshF 6.3.2.2, 6.3.2.29, 6.3.2.30, 6.3.2.4 H Belongs to the glutamate--cysteine ligase type 1 family
AAKFIGLK_00005 1.3e-282 S Protein of unknown function (DUF3114)
AAKFIGLK_00006 6.5e-99 2.3.1.128 K Acetyltransferase GNAT Family
AAKFIGLK_00007 0.0 glgP 2.4.1.1 GT35 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
AAKFIGLK_00008 9.2e-283 glgA 2.4.1.21 GT5 G Synthesizes alpha-1,4-glucan chains using ADP-glucose
AAKFIGLK_00009 1.8e-180 glgD 2.4.1.21, 2.7.7.27 GT5 G glucose-1-phosphate adenylyltransferase
AAKFIGLK_00010 5.8e-187 glgC 2.7.7.27 H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AAKFIGLK_00011 0.0 glgB 2.4.1.18, 3.2.1.141, 3.2.1.20 CBM48,GH13,GH31 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AAKFIGLK_00012 0.0 pulA 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
AAKFIGLK_00013 0.0 ftsK D Belongs to the FtsK SpoIIIE SftA family
AAKFIGLK_00014 1.2e-185 trxB1 1.18.1.2, 1.19.1.1 C Ferredoxin--NADP reductase
AAKFIGLK_00015 1.9e-135 trmD 2.1.1.228, 4.6.1.12 J Belongs to the RNA methyltransferase TrmD family
AAKFIGLK_00016 7.6e-94 rimM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AAKFIGLK_00019 3.1e-113 vraR K Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
AAKFIGLK_00020 9.7e-170 vraS 2.7.13.3 T Histidine kinase
AAKFIGLK_00021 5e-117 yvqF S Membrane
AAKFIGLK_00022 2.1e-100 kcsA P Ion transport protein
AAKFIGLK_00023 4.4e-293 prkC 2.7.11.1 KLT serine threonine protein kinase
AAKFIGLK_00024 2e-135 stp 3.1.3.16 T phosphatase
AAKFIGLK_00025 5e-243 sun 2.1.1.176 J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AAKFIGLK_00026 2.4e-170 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AAKFIGLK_00027 0.0 priA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AAKFIGLK_00028 3.6e-46 rpoZ 2.7.7.6 K DNA-directed 5'-3' RNA polymerase activity
AAKFIGLK_00029 4.4e-112 gmk 2.7.4.8 F Essential for recycling GMP and indirectly, cGMP
AAKFIGLK_00030 1.8e-195 ftsY U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
AAKFIGLK_00031 4.3e-144 XK27_02985 S overlaps another CDS with the same product name
AAKFIGLK_00032 1.1e-144 supH S overlaps another CDS with the same product name
AAKFIGLK_00033 2.5e-62 yvoA_1 K Transcriptional
AAKFIGLK_00034 5.4e-119 skfE V abc transporter atp-binding protein
AAKFIGLK_00035 2.9e-129 V Psort location CytoplasmicMembrane, score
AAKFIGLK_00036 1.2e-171 oppF P Belongs to the ABC transporter superfamily
AAKFIGLK_00037 4.6e-202 oppD P Belongs to the ABC transporter superfamily
AAKFIGLK_00038 3.8e-165 amiD P ABC transporter (Permease
AAKFIGLK_00039 2.7e-277 amiC P ABC transporter (Permease
AAKFIGLK_00040 2.7e-311 amiA E ABC transporter, substrate-binding protein, family 5
AAKFIGLK_00041 0.0 amiA E ABC transporter, substrate-binding protein, family 5
AAKFIGLK_00042 1.8e-176 pta 2.3.1.8, 3.6.3.21 C phosphate acetyltransferase
AAKFIGLK_00043 9.2e-172 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 J Responsible for synthesis of pseudouridine from uracil
AAKFIGLK_00044 3.7e-151 nadK 2.7.1.23 H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AAKFIGLK_00045 3e-119 yjbM 2.7.6.5 S Gtp pyrophosphokinase
AAKFIGLK_00046 2.4e-101 yjbK S Adenylate cyclase
AAKFIGLK_00047 5.1e-176 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AAKFIGLK_00048 1.2e-205 iscS 2.8.1.7 E Cysteine desulfurase
AAKFIGLK_00049 1.1e-59 XK27_04120 S Putative amino acid metabolism
AAKFIGLK_00050 1.9e-118 rex K Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AAKFIGLK_00051 2.2e-128 puuD T peptidase C26
AAKFIGLK_00052 5.8e-118 radC E Belongs to the UPF0758 family
AAKFIGLK_00053 3.6e-168
AAKFIGLK_00054 6.9e-43 M Psort location CytoplasmicMembrane, score
AAKFIGLK_00055 1.6e-155 rfbJ M Glycosyl transferase family 2
AAKFIGLK_00056 0.0 rgpF M Rhamnan synthesis protein F
AAKFIGLK_00057 9.6e-181 rgpEc GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
AAKFIGLK_00058 1.8e-223 rgpD 3.6.3.38 P Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system
AAKFIGLK_00059 2e-141 rgpC GM Transport permease protein
AAKFIGLK_00060 1.5e-172 rgpB GT2 M Glycosyltransferase, group 2 family protein
AAKFIGLK_00061 2.5e-214 rgpA GT4 M Domain of unknown function (DUF1972)
AAKFIGLK_00062 8.4e-159 rfbD 1.1.1.133, 5.1.3.13 M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
AAKFIGLK_00063 2e-169 yfdH GT2 M COG0463, glycosyltransferases involved in cell wall biogenesis
AAKFIGLK_00064 3.4e-55 yitW K metal-sulfur cluster biosynthetic enzyme
AAKFIGLK_00065 4e-201 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
AAKFIGLK_00066 0.0 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
AAKFIGLK_00067 1.6e-48 mscL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
AAKFIGLK_00068 3.2e-20 rpsU J Belongs to the bacterial ribosomal protein bS21 family
AAKFIGLK_00069 1e-129 gltS ET Belongs to the bacterial solute-binding protein 3 family
AAKFIGLK_00070 4e-201 arcT 2.6.1.1 E Aminotransferase
AAKFIGLK_00071 9.4e-136 ET Belongs to the bacterial solute-binding protein 3 family
AAKFIGLK_00072 3.2e-139 ET ABC transporter
AAKFIGLK_00073 1.4e-83 mutT 3.6.1.55 F Nudix family
AAKFIGLK_00074 0.0 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
AAKFIGLK_00076 1.5e-164 S CAAX amino terminal protease family protein
AAKFIGLK_00077 0.0 glnP P ABC-type amino acid transport signal transduction systems periplasmic component domain
AAKFIGLK_00078 1e-136 glnQ 3.6.3.21 E abc transporter atp-binding protein
AAKFIGLK_00079 1.7e-17 XK27_00735
AAKFIGLK_00080 8.8e-248 obg S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AAKFIGLK_00082 1.6e-126 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
AAKFIGLK_00083 9.8e-10 O ADP-ribosylglycohydrolase
AAKFIGLK_00084 7.4e-62 paaI Q protein possibly involved in aromatic compounds catabolism
AAKFIGLK_00085 7.8e-61 ycaO O OsmC-like protein
AAKFIGLK_00087 1.7e-149 EG Permeases of the drug metabolite transporter (DMT) superfamily
AAKFIGLK_00088 6.5e-08 N PFAM Uncharacterised protein family UPF0150
AAKFIGLK_00089 2.9e-111 serB 3.1.3.3 E phosphoserine phosphatase
AAKFIGLK_00090 3.2e-298 ezrA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
AAKFIGLK_00091 0.0 gyrB 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AAKFIGLK_00092 5.1e-96 3.1.3.18 S IA, variant 1
AAKFIGLK_00093 9.4e-116 lrgB M Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like proteins CidA and or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses
AAKFIGLK_00094 5.9e-56 lrgA S Effector of murein hydrolase LrgA
AAKFIGLK_00096 5.4e-59 arsC 1.20.4.1 P Belongs to the ArsC family
AAKFIGLK_00097 1.8e-73 ogt 2.1.1.63, 3.2.2.20 L methylated-DNA-[protein]-cysteine S-methyltransferase activity
AAKFIGLK_00098 4.5e-219 serA 1.1.1.399, 1.1.1.95 EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AAKFIGLK_00099 1.6e-102 wecD M Acetyltransferase (GNAT) domain
AAKFIGLK_00100 3.3e-208 serC 2.6.1.52 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AAKFIGLK_00101 4.3e-92 GK ROK family
AAKFIGLK_00102 3.1e-54 GK ROK family
AAKFIGLK_00103 1.8e-71 gloA 4.4.1.5 E Lactoylglutathione lyase
AAKFIGLK_00104 1.9e-145 XK27_08050 O HflC and HflK could regulate a protease
AAKFIGLK_00105 1.3e-204 potD P spermidine putrescine ABC transporter
AAKFIGLK_00106 2.6e-130 potC P ABC-type spermidine putrescine transport system, permease component II
AAKFIGLK_00107 1.8e-139 potB P ABC-type spermidine putrescine transport system, permease component I
AAKFIGLK_00108 5.2e-212 potA 3.6.3.30, 3.6.3.31 P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
AAKFIGLK_00109 3.4e-166 murB 1.3.1.98 M cell wall formation
AAKFIGLK_00110 4.7e-77 folK 2.7.6.3, 4.1.2.25 H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AAKFIGLK_00111 9.3e-59 folB 1.13.11.81, 2.5.1.15, 2.7.6.3, 4.1.2.25, 5.1.99.8 H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AAKFIGLK_00112 4e-286 amy 3.2.1.1 GH13 G Belongs to the glycosyl hydrolase 13 family
AAKFIGLK_00113 1e-142 folP 2.5.1.15, 2.7.6.3 H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AAKFIGLK_00114 7.7e-100 folE 3.5.4.16 F gtp cyclohydrolase
AAKFIGLK_00115 0.0 ydaO E amino acid
AAKFIGLK_00116 9.1e-234 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
AAKFIGLK_00117 3.5e-36 ylqC L Belongs to the UPF0109 family
AAKFIGLK_00118 2.4e-43 rpsP J Belongs to the bacterial ribosomal protein bS16 family
AAKFIGLK_00120 1.1e-210 2.7.13.3 T protein histidine kinase activity
AAKFIGLK_00121 2.2e-123 agrA KT phosphorelay signal transduction system
AAKFIGLK_00122 7.8e-161 O protein import
AAKFIGLK_00123 1.5e-166 tehB 2.1.1.265 PQ tellurite resistance protein tehb
AAKFIGLK_00124 2.9e-17 yjdB S Domain of unknown function (DUF4767)
AAKFIGLK_00126 3.4e-157 xth 3.1.11.2 L exodeoxyribonuclease III
AAKFIGLK_00127 5.4e-70 S QueT transporter
AAKFIGLK_00129 3.8e-171 yfjR K regulation of single-species biofilm formation
AAKFIGLK_00131 2.4e-184 yegS 2.7.1.107 I Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
AAKFIGLK_00132 0.0 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AAKFIGLK_00133 1.1e-84 ccl S cog cog4708
AAKFIGLK_00134 8.4e-160 rbn E Belongs to the UPF0761 family
AAKFIGLK_00135 1.1e-166 map 3.4.11.18 E Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed
AAKFIGLK_00136 2.5e-231 ytoI K transcriptional regulator containing CBS domains
AAKFIGLK_00137 5.3e-98 XK27_07830 2.3.1.128 J Acetyltransferase GNAT Family
AAKFIGLK_00138 5.1e-229 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AAKFIGLK_00139 0.0 comEC S Competence protein ComEC
AAKFIGLK_00140 2.2e-88 comEA L COG1555 DNA uptake protein and related DNA-binding proteins
AAKFIGLK_00141 1.3e-142 plsC 2.3.1.51 I Acyltransferase
AAKFIGLK_00142 9.3e-159 nodB3 G deacetylase
AAKFIGLK_00143 1.8e-139 yabB 2.1.1.223 L Methyltransferase
AAKFIGLK_00144 1e-41 yazA L endonuclease containing a URI domain
AAKFIGLK_00145 1.7e-253 cshA 3.6.4.13 JKL DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
AAKFIGLK_00146 7.6e-150 corA P CorA-like protein
AAKFIGLK_00147 9.6e-62 yjqA S Bacterial PH domain
AAKFIGLK_00148 2.4e-96 thiT S Thiamine transporter
AAKFIGLK_00149 2.3e-300 prfC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AAKFIGLK_00150 9.6e-118 ywaF S Integral membrane protein (intg_mem_TP0381)
AAKFIGLK_00151 6.6e-254 murF 6.3.2.10 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
AAKFIGLK_00155 9.7e-155 cjaA ET ABC transporter substrate-binding protein
AAKFIGLK_00156 3.4e-135 glnQ 3.6.3.21 E abc transporter atp-binding protein
AAKFIGLK_00157 3e-106 P ABC transporter (Permease
AAKFIGLK_00158 1.1e-113 papP P ABC transporter (Permease
AAKFIGLK_00159 6e-191 ddl 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
AAKFIGLK_00160 2.7e-31 copZ 2.7.7.77 P Heavy metal-associated domain protein
AAKFIGLK_00161 0.0 copA 3.6.3.54 P P-type ATPase
AAKFIGLK_00162 7.2e-74 copY K negative regulation of transcription, DNA-templated
AAKFIGLK_00164 1.9e-141 trpA 4.2.1.20 E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
AAKFIGLK_00165 5.8e-230 trpB 4.2.1.20, 5.3.1.24 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
AAKFIGLK_00166 2.8e-97 trpF 4.1.1.48, 4.2.1.160, 4.2.1.20, 5.3.1.24 E belongs to the TrpF family
AAKFIGLK_00167 3.6e-132 trpC 4.1.1.48, 5.3.1.24 E Belongs to the TrpC family
AAKFIGLK_00168 3e-179 trpD 2.4.2.18, 4.1.3.27 F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AAKFIGLK_00169 1e-104 trpG 2.4.2.18, 2.6.1.85, 4.1.3.27 EH anthranilate
AAKFIGLK_00170 5.5e-101 trpE 4.1.3.27 EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AAKFIGLK_00171 5e-111 tcyB_2 P ABC transporter (permease)
AAKFIGLK_00172 2e-155 endA F DNA RNA non-specific endonuclease
AAKFIGLK_00173 7.2e-26 epuA S DNA-directed RNA polymerase subunit beta
AAKFIGLK_00174 5.5e-231 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AAKFIGLK_00175 1e-193 G Belongs to the glycosyl hydrolase 8 (cellulase D) family
AAKFIGLK_00176 7.4e-247 ydaM M Glycosyltransferases, probably involved in cell wall biogenesis
AAKFIGLK_00178 1e-131
AAKFIGLK_00179 2.5e-214 mnaA 5.1.3.14 G Belongs to the UDP-N-acetylglucosamine 2-epimerase family
AAKFIGLK_00180 2.6e-40 pchB 2.5.1.19, 4.2.1.10, 4.2.99.21, 5.4.99.5 E Chorismate mutase
AAKFIGLK_00181 1.1e-57
AAKFIGLK_00182 0.0 ctpE P E1-E2 ATPase
AAKFIGLK_00183 2e-46
AAKFIGLK_00184 2.8e-18 fruR K transcriptional
AAKFIGLK_00185 4.3e-36 pfkB 2.7.1.11, 2.7.1.56 H Belongs to the carbohydrate kinase PfkB family. LacC subfamily
AAKFIGLK_00186 1.1e-165 T Diguanylate cyclase
AAKFIGLK_00187 1.7e-148 2.4.1.83 GT2 M COG0463, glycosyltransferases involved in cell wall biogenesis
AAKFIGLK_00188 0.0 bcsA 2.4.1.12 GT2 M COG1215 Glycosyltransferases, probably involved in cell wall biogenesis
AAKFIGLK_00189 0.0
AAKFIGLK_00190 6.2e-76
AAKFIGLK_00191 2.2e-35 K Peptidase S24-like protein
AAKFIGLK_00192 4.5e-69 K Peptidase S24-like protein
AAKFIGLK_00193 2e-111 E IrrE N-terminal-like domain
AAKFIGLK_00194 3.4e-93
AAKFIGLK_00195 2.4e-79
AAKFIGLK_00196 7.1e-44
AAKFIGLK_00197 2e-46
AAKFIGLK_00198 1.2e-43 yaaK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AAKFIGLK_00200 9.5e-124 V abc transporter atp-binding protein
AAKFIGLK_00201 0.0 V ABC transporter (Permease
AAKFIGLK_00202 1.9e-127 K transcriptional regulator, MerR family
AAKFIGLK_00203 8.3e-105 dnaQ 2.7.7.7 L DNA polymerase III
AAKFIGLK_00204 9.1e-42 WQ51_02910 S Protein of unknown function, DUF536
AAKFIGLK_00205 9.6e-64 XK27_02560 S cog cog2151
AAKFIGLK_00206 0.0 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
AAKFIGLK_00207 1.7e-221 ytfP S Flavoprotein
AAKFIGLK_00209 2e-120 trmB 2.1.1.297, 2.1.1.33 J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
AAKFIGLK_00210 7.1e-152 ytmP 2.7.1.89 M Phosphotransferase
AAKFIGLK_00211 2.7e-175 ecsB U Bacterial ABC transporter protein EcsB
AAKFIGLK_00212 9.2e-130 ecsA V abc transporter atp-binding protein
AAKFIGLK_00213 1.1e-71 hit FG Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
AAKFIGLK_00214 4.2e-12
AAKFIGLK_00216 1.6e-103
AAKFIGLK_00218 0.0 clpL O ATP-dependent Clp protease ATP-binding subunit
AAKFIGLK_00219 7.9e-44 yoeB S Addiction module toxin, Txe YoeB family
AAKFIGLK_00220 7.6e-39 yefM 2.3.1.15 D Antitoxin component of a toxin-antitoxin (TA) module
AAKFIGLK_00221 2e-197 ylbM S Belongs to the UPF0348 family
AAKFIGLK_00222 2.5e-138 yqeM Q Methyltransferase domain protein
AAKFIGLK_00223 4.6e-58 rsfS J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
AAKFIGLK_00224 2.9e-105 nadD 2.7.6.3, 2.7.7.18 H HD superfamily hydrolase involved in NAD metabolism
AAKFIGLK_00225 1.2e-117 nadD 2.7.7.18, 3.6.1.55 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AAKFIGLK_00226 7.7e-49 yhbY J RNA-binding protein
AAKFIGLK_00227 4.1e-214 yqeH S in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis
AAKFIGLK_00228 1.4e-98 yqeG S hydrolase of the HAD superfamily
AAKFIGLK_00229 2.9e-149 yicL EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
AAKFIGLK_00230 1.5e-62
AAKFIGLK_00232 1.1e-272 gatB 6.1.1.12, 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AAKFIGLK_00233 8.5e-268 gatA 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
AAKFIGLK_00234 1.5e-46 gatC 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AAKFIGLK_00235 3.9e-236 2.4.1.52 GT4 M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
AAKFIGLK_00236 1.8e-189 M A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1
AAKFIGLK_00237 1.8e-156 H COG0463 Glycosyltransferases involved in cell wall biogenesis
AAKFIGLK_00238 3.3e-217 M lipopolysaccharide 3-alpha-galactosyltransferase activity
AAKFIGLK_00239 2.2e-292 ascB 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
AAKFIGLK_00240 6.4e-99 pncA Q isochorismatase
AAKFIGLK_00241 8.1e-140 codY K DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AAKFIGLK_00242 1.7e-237 alaA 2.6.1.2, 2.6.1.66 E Aminotransferase
AAKFIGLK_00243 9e-75 XK27_03180 T universal stress protein
AAKFIGLK_00245 2e-157 pflA 1.97.1.4 C Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AAKFIGLK_00246 8.1e-09 MU outer membrane autotransporter barrel domain protein
AAKFIGLK_00247 3.2e-237 hlyX S COG1253 Hemolysins and related proteins containing CBS domains
AAKFIGLK_00248 1.2e-140 modF 3.6.3.21, 3.6.3.34 P abc transporter atp-binding protein
AAKFIGLK_00250 1.8e-24
AAKFIGLK_00252 0.0 yjcE P NhaP-type Na H and K H antiporters
AAKFIGLK_00254 3.2e-95 ytqB J (SAM)-dependent
AAKFIGLK_00255 9.3e-183 yhcC S radical SAM protein
AAKFIGLK_00256 3.2e-187 ylbL T Belongs to the peptidase S16 family
AAKFIGLK_00257 1.7e-87 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AAKFIGLK_00258 1.3e-91 rsmD 2.1.1.171 L Methyltransferase
AAKFIGLK_00259 2.1e-171 trxB 1.8.1.9 C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
AAKFIGLK_00260 5e-10 S Protein of unknown function (DUF4059)
AAKFIGLK_00261 2.1e-129 tcyN 3.6.3.21 E abc transporter atp-binding protein
AAKFIGLK_00262 1e-157 yxeN P ABC transporter (Permease
AAKFIGLK_00263 2.2e-151 yxeM ET ABC-type amino acid transport signal transduction systems, periplasmic component domain
AAKFIGLK_00264 5.6e-14
AAKFIGLK_00265 1.3e-15
AAKFIGLK_00266 4.8e-07 M LXG domain of WXG superfamily
AAKFIGLK_00267 1e-34
AAKFIGLK_00268 1.2e-202 dinB 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AAKFIGLK_00269 0.0 pflB 2.3.1.54 C formate acetyltransferase'
AAKFIGLK_00270 5.1e-142 cah 4.2.1.1 P carbonic anhydrase
AAKFIGLK_00271 5.4e-72 yjcF S COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
AAKFIGLK_00273 8.7e-173 ampC V COG1680 Beta-lactamase class C and other penicillin binding proteins
AAKFIGLK_00274 1.2e-137 cppA E CppA N-terminal
AAKFIGLK_00275 8.3e-93 V CAAX protease self-immunity
AAKFIGLK_00276 1.1e-148 gla U Belongs to the MIP aquaporin (TC 1.A.8) family
AAKFIGLK_00277 0.0 pepX 3.4.14.11 E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline
AAKFIGLK_00278 2.4e-44 spiA K sequence-specific DNA binding
AAKFIGLK_00287 0.0 mdlB V abc transporter atp-binding protein
AAKFIGLK_00288 0.0 mdlA V abc transporter atp-binding protein
AAKFIGLK_00291 9.7e-89 XK27_09885 V Glycopeptide antibiotics resistance protein
AAKFIGLK_00292 1.8e-223 rlmN 2.1.1.192 J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
AAKFIGLK_00293 5.6e-63 yutD J protein conserved in bacteria
AAKFIGLK_00294 2e-255 yunD 3.1.3.5 F Belongs to the 5'-nucleotidase family
AAKFIGLK_00296 1.2e-220 cshB 3.6.4.13 JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
AAKFIGLK_00297 1.1e-184 mraY 2.7.8.13 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AAKFIGLK_00298 0.0 ftsI 3.4.16.4 M penicillin-binding protein
AAKFIGLK_00299 2.4e-45 ftsL D cell division protein FtsL
AAKFIGLK_00300 1.1e-172 rsmH 2.1.1.199 J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
AAKFIGLK_00301 7.9e-90
AAKFIGLK_00303 3.5e-46 yhaI J Protein of unknown function (DUF805)
AAKFIGLK_00304 3.4e-62 yhaI J Protein of unknown function (DUF805)
AAKFIGLK_00305 2.3e-32 yhaI J Protein of unknown function (DUF805)
AAKFIGLK_00306 3.2e-60 yhaI J Membrane
AAKFIGLK_00307 5.5e-223 proA 1.2.1.41 E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AAKFIGLK_00308 1.7e-140 proB 2.7.2.11 E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AAKFIGLK_00309 2.1e-275 XK27_00765
AAKFIGLK_00310 7.6e-132 ecsA_2 V abc transporter atp-binding protein
AAKFIGLK_00311 3.4e-124 S Protein of unknown function (DUF554)
AAKFIGLK_00312 0.0 addA 3.6.4.12 L ATP-dependent helicase nuclease subunit A
AAKFIGLK_00313 0.0 rexB 3.1.21.3, 3.6.4.12 L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AAKFIGLK_00314 1.2e-239 2.7.13.3 T protein histidine kinase activity
AAKFIGLK_00315 1.3e-227 dcuS 2.7.13.3 T protein histidine kinase activity
AAKFIGLK_00316 1.5e-13
AAKFIGLK_00319 5.8e-146 V Psort location CytoplasmicMembrane, score
AAKFIGLK_00321 3e-298 O MreB/Mbl protein
AAKFIGLK_00322 3.4e-129 mccF V LD-carboxypeptidase
AAKFIGLK_00323 6.1e-177 holA 2.7.7.7 L DNA polymerase III delta subunit
AAKFIGLK_00324 2.7e-111 sodA 1.15.1.1 C radicals which are normally produced within the cells and which are toxic to biological systems
AAKFIGLK_00325 2.9e-164 3.5.2.6 V D-alanyl-D-alanine carboxypeptidase
AAKFIGLK_00326 1.2e-99 pilD 3.4.23.43 NOU Type II secretory pathway prepilin signal peptidase PulO and related peptidases
AAKFIGLK_00327 4.5e-78 dps P Belongs to the Dps family
AAKFIGLK_00328 3.8e-78 perR P Belongs to the Fur family
AAKFIGLK_00329 4.2e-27 yqgQ S protein conserved in bacteria
AAKFIGLK_00330 3.3e-175 glk 2.7.1.2 G Glucokinase
AAKFIGLK_00331 0.0 typA T GTP-binding protein TypA
AAKFIGLK_00333 1.7e-246 murD 6.3.2.9 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AAKFIGLK_00334 3.1e-198 murG 2.4.1.227 GT28 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AAKFIGLK_00335 6.7e-135 divIB D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
AAKFIGLK_00336 3.5e-223 ftsA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
AAKFIGLK_00337 4.3e-234 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AAKFIGLK_00338 2.8e-120 ylmE S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AAKFIGLK_00339 1e-89 sepF D cell septum assembly
AAKFIGLK_00340 1.7e-30 yggT D integral membrane protein
AAKFIGLK_00341 2.9e-137 ylmH S conserved protein, contains S4-like domain
AAKFIGLK_00342 1.9e-137 divIVA D Cell division initiation protein
AAKFIGLK_00343 0.0 ileS 6.1.1.5 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AAKFIGLK_00344 8.5e-184 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AAKFIGLK_00345 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AAKFIGLK_00346 6.5e-34 nrdH O Glutaredoxin
AAKFIGLK_00347 0.0 acnA 4.2.1.3 C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AAKFIGLK_00348 2.4e-209 citZ 2.3.3.1 C Belongs to the citrate synthase family
AAKFIGLK_00349 7.7e-219 icd 1.1.1.42 C Isocitrate dehydrogenase
AAKFIGLK_00350 3e-38 ptsH G phosphocarrier protein Hpr
AAKFIGLK_00351 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AAKFIGLK_00352 6.6e-265 gapN 1.2.1.9 C Belongs to the aldehyde dehydrogenase family
AAKFIGLK_00353 4.3e-160 XK27_05670 S Putative esterase
AAKFIGLK_00354 2.7e-153 XK27_05675 S Esterase
AAKFIGLK_00355 5.4e-225 XK27_05680 6.3.2.2, 6.3.2.4 M carbamoylphosphate synthase large subunit
AAKFIGLK_00356 6e-178 yfmL 3.6.4.13 L DEAD DEAH box helicase
AAKFIGLK_00357 3.1e-113 udk 2.7.1.48 F Cytidine monophosphokinase
AAKFIGLK_00358 0.0 uup S abc transporter atp-binding protein
AAKFIGLK_00359 2.7e-39 MA20_06245 S yiaA/B two helix domain
AAKFIGLK_00360 9.7e-132 pip 1.11.1.10 S Alpha beta hydrolase
AAKFIGLK_00361 0.0 mprF 2.3.2.3 J Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AAKFIGLK_00362 8.1e-148 cobQ S glutamine amidotransferase
AAKFIGLK_00363 8.4e-254 murD 3.4.21.10, 6.3.2.13, 6.3.2.9 M Mur ligase, middle domain protein
AAKFIGLK_00364 2.7e-149 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AAKFIGLK_00365 3.2e-162 ybbR S Protein conserved in bacteria
AAKFIGLK_00366 3.7e-249 glmM 5.4.2.10 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AAKFIGLK_00367 1.8e-66 gtrA S GtrA-like protein
AAKFIGLK_00368 3.7e-120 trmK 2.1.1.217 S SAM-dependent methyltransferase
AAKFIGLK_00369 1.3e-142 yqfO 3.5.4.16 S Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AAKFIGLK_00370 3.3e-144 zupT P Mediates zinc uptake. May also transport other divalent cations
AAKFIGLK_00371 5.1e-193 yurR 1.4.5.1 E oxidoreductase
AAKFIGLK_00372 9e-256 S phospholipase Carboxylesterase
AAKFIGLK_00373 2.4e-161 rfbA 2.7.7.24 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AAKFIGLK_00374 1.4e-112 rmlC 1.1.1.133, 5.1.3.13 M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
AAKFIGLK_00375 1.3e-204 rfbB 4.2.1.46 M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
AAKFIGLK_00377 2.2e-30 KT response to antibiotic
AAKFIGLK_00378 2.9e-215 hemN H Involved in the biosynthesis of porphyrin-containing compound
AAKFIGLK_00379 1.1e-141 fat 3.1.2.21 I Acyl-ACP thioesterase
AAKFIGLK_00380 8.8e-139 nagD 2.7.1.25, 3.1.3.41 G Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
AAKFIGLK_00381 6e-117 ylfI S tigr01906
AAKFIGLK_00382 2.8e-134 hisK 3.1.3.15 E Histidinol phosphatase and related hydrolases of the PHP family
AAKFIGLK_00383 1.4e-146 XK27_08080 3.1.1.53 G Exopolysaccharide biosynthesis protein
AAKFIGLK_00384 2.1e-59 XK27_08085
AAKFIGLK_00385 1.8e-190 hisC 2.6.1.9 E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AAKFIGLK_00386 4.8e-182 hisZ 2.4.2.17, 6.1.1.21 E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AAKFIGLK_00387 4e-116 hisG 2.4.2.17 E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
AAKFIGLK_00388 4.6e-233 hisD 1.1.1.23, 1.1.1.308 E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AAKFIGLK_00389 3.9e-107 hisB 1.1.1.23, 2.6.1.9, 3.1.3.15, 4.2.1.19 E imidazoleglycerol-phosphate dehydratase
AAKFIGLK_00390 1.7e-108 hisH E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AAKFIGLK_00391 4.5e-129 hisA 5.3.1.16 E 1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AAKFIGLK_00392 9.6e-138 hisF 3.5.4.19, 3.6.1.31 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
AAKFIGLK_00393 1e-59 hisI 3.5.4.19, 3.5.4.25, 3.6.1.31, 5.3.1.16 E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AAKFIGLK_00394 4.1e-50 hisE 3.5.4.19, 3.6.1.31, 5.3.1.16 E phosphoribosyl-ATP diphosphatase activity
AAKFIGLK_00396 3.8e-93 XK27_05505 S Psort location CytoplasmicMembrane, score
AAKFIGLK_00397 3.2e-144 P molecular chaperone
AAKFIGLK_00398 4.7e-97 S Carbohydrate-binding domain-containing protein Cthe_2159
AAKFIGLK_00399 2.7e-175 XK27_08075 M glycosyl transferase family 2
AAKFIGLK_00400 0.0 2.4.1.5 GH13 M KxYKxGKxW signal domain protein
AAKFIGLK_00401 0.0 2.4.1.5 GH13 M KxYKxGKxW signal domain protein
AAKFIGLK_00402 0.0 2.4.1.5 GH13 M KxYKxGKxW signal domain protein
AAKFIGLK_00403 9.9e-229 rodA D Belongs to the SEDS family
AAKFIGLK_00404 5.5e-245 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AAKFIGLK_00405 1.4e-113 galT 2.7.7.12 G UDPglucose--hexose-1-phosphate uridylyltransferase
AAKFIGLK_00406 2.7e-174 rnz 3.1.26.11 S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
AAKFIGLK_00407 2.2e-134 XK27_05435 1.1.1.100 S Belongs to the short-chain dehydrogenases reductases (SDR) family
AAKFIGLK_00408 7.5e-21 Q Methyltransferase domain
AAKFIGLK_00409 1.5e-65 GnaT 2.5.1.16 K acetyltransferase
AAKFIGLK_00410 0.0 recJ L Single-strand DNA-specific exonuclease, C terminal domain
AAKFIGLK_00411 4.9e-93 apt 2.4.2.7 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AAKFIGLK_00412 9.3e-183 metA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AAKFIGLK_00413 1.3e-125 dnaD
AAKFIGLK_00414 4.2e-118 nth 4.2.99.18 L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AAKFIGLK_00416 1.4e-232 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
AAKFIGLK_00417 4.6e-29 xseB 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
AAKFIGLK_00418 3.4e-155 ispA 2.5.1.1, 2.5.1.10, 2.5.1.29, 2.5.1.90 H Belongs to the FPP GGPP synthase family
AAKFIGLK_00419 4.7e-146 rrmJ 2.1.1.226, 2.1.1.227 J Ribosomal RNA large subunit methyltransferase J
AAKFIGLK_00420 7.5e-74 argR K Regulates arginine biosynthesis genes
AAKFIGLK_00421 2.3e-293 recN L May be involved in recombinational repair of damaged DNA
AAKFIGLK_00422 1.2e-144 DegV S DegV family
AAKFIGLK_00423 2.7e-152 ypmR E COG2755 Lysophospholipase L1 and related esterases
AAKFIGLK_00424 1.7e-94 ypmS S Protein conserved in bacteria
AAKFIGLK_00425 6.3e-39 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
AAKFIGLK_00427 1.8e-178 pyrD 1.3.1.14, 1.3.98.1 F Catalyzes the conversion of dihydroorotate to orotate
AAKFIGLK_00428 3.6e-131 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AAKFIGLK_00429 4.2e-289 leuA 2.3.3.13 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AAKFIGLK_00430 2.8e-188 leuB 1.1.1.85 CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
AAKFIGLK_00431 2.8e-276 leuC 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AAKFIGLK_00432 2.4e-112 leuD 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AAKFIGLK_00433 0.0 dnaE 2.7.7.7 L DNA polymerase
AAKFIGLK_00434 7.9e-188 pfkA 2.7.1.11 F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
AAKFIGLK_00435 6e-277 pyk 2.7.1.40, 2.7.7.4 G Belongs to the pyruvate kinase family
AAKFIGLK_00436 2.3e-108 plsY 2.3.1.15, 3.5.1.104 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
AAKFIGLK_00437 0.0 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
AAKFIGLK_00439 7.6e-09
AAKFIGLK_00440 0.0 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
AAKFIGLK_00441 1.7e-198 ilvE 2.6.1.42 E Aminotransferase
AAKFIGLK_00442 4.8e-16 S Protein of unknown function (DUF2969)
AAKFIGLK_00445 2.5e-204 rpsA 1.17.7.4 J ribosomal protein S1
AAKFIGLK_00448 1.9e-107 S Domain of Unknown Function with PDB structure (DUF3862)
AAKFIGLK_00449 2.9e-117 M Pfam SNARE associated Golgi protein
AAKFIGLK_00450 5e-229 murN 2.3.2.16 V FemAB family
AAKFIGLK_00451 5.8e-172 S oxidoreductase
AAKFIGLK_00452 6.2e-48 XK27_09445 S Domain of unknown function (DUF1827)
AAKFIGLK_00453 1.1e-83 mutT 3.5.4.33, 3.6.1.13, 3.6.1.55 L Belongs to the Nudix hydrolase family
AAKFIGLK_00454 0.0 clpE O Belongs to the ClpA ClpB family
AAKFIGLK_00455 4.1e-181 argF 2.1.3.3 E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AAKFIGLK_00456 1.1e-33 ykuJ S protein conserved in bacteria
AAKFIGLK_00457 5.8e-118 WQ51_01820 P Binding-protein-dependent transport system inner membrane component
AAKFIGLK_00458 1.4e-130 glnQ 3.6.3.21 E abc transporter atp-binding protein
AAKFIGLK_00459 1.7e-76 feoA P FeoA domain protein
AAKFIGLK_00460 0.0 feoB P transporter of a GTP-driven Fe(2 ) uptake system
AAKFIGLK_00461 6.6e-08
AAKFIGLK_00462 6.1e-148 I Alpha/beta hydrolase family
AAKFIGLK_00463 2.4e-153 folD 1.5.1.5, 3.5.4.9 F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AAKFIGLK_00464 1.4e-142 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AAKFIGLK_00465 0.0 pbp2b 3.4.16.4 M penicillin-binding protein
AAKFIGLK_00466 1.3e-105 recR L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AAKFIGLK_00467 6.8e-145 licT K antiterminator
AAKFIGLK_00468 1.3e-87 ybeY 2.6.99.2, 3.5.4.5 S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AAKFIGLK_00469 6.4e-64 dgkA 2.7.1.107, 2.7.1.66 M Diacylglycerol kinase
AAKFIGLK_00470 3.4e-166 era M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AAKFIGLK_00471 3.9e-145 fpg 3.2.2.23, 4.2.99.18 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
AAKFIGLK_00472 1.5e-93 coaE 2.7.1.24, 3.2.2.23, 4.2.99.18 GH23 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AAKFIGLK_00473 1e-221 mdtG EGP Major facilitator Superfamily
AAKFIGLK_00474 2e-33 secG U Preprotein translocase subunit SecG
AAKFIGLK_00475 0.0 rnr J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
AAKFIGLK_00476 6.6e-81 smpB O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
AAKFIGLK_00477 1.5e-274 ppiB 5.2.1.8 G PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AAKFIGLK_00478 8.4e-63 yugI 5.3.1.9 J RNA binding protein, contains ribosomal protein S1 domain
AAKFIGLK_00479 2.4e-195 pepQ 3.4.13.9 E Belongs to the peptidase M24B family
AAKFIGLK_00480 1.9e-181 ccpA K Catabolite control protein A
AAKFIGLK_00481 1e-190 yyaQ S YjbR
AAKFIGLK_00482 1.2e-192 glxK 2.7.1.165 G Belongs to the glycerate kinase type-1 family
AAKFIGLK_00483 8.7e-78 yueI S Protein of unknown function (DUF1694)
AAKFIGLK_00484 7.4e-247 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
AAKFIGLK_00485 4.6e-25 WQ51_00785
AAKFIGLK_00486 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
AAKFIGLK_00487 1.8e-215 ywbD 2.1.1.191 J Methyltransferase
AAKFIGLK_00488 4.4e-118 aroD 1.1.1.25, 4.2.1.10 E Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
AAKFIGLK_00489 2.2e-159 aroE 1.1.1.25 E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AAKFIGLK_00490 5.9e-202 aroB 2.7.1.71, 4.2.3.4 E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AAKFIGLK_00491 1.9e-217 aroC 4.2.3.5 E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AAKFIGLK_00492 2.7e-205 tyrA 1.3.1.12, 1.3.1.43 E prephenate dehydrogenase
AAKFIGLK_00493 4.2e-53 yheA S Belongs to the UPF0342 family
AAKFIGLK_00494 2.6e-169 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
AAKFIGLK_00495 2.7e-233 aroA 1.3.1.12, 1.3.1.43, 2.5.1.19 E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
AAKFIGLK_00496 2.7e-77 aroK 1.1.1.25, 2.7.1.71, 4.2.1.10, 4.2.3.4 F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AAKFIGLK_00497 1.4e-153 pheA 4.2.1.51 E Prephenate dehydratase
AAKFIGLK_00498 4.4e-237 msrR K Transcriptional regulator
AAKFIGLK_00499 3.8e-152 ydiA P C4-dicarboxylate transporter malic acid transport
AAKFIGLK_00500 1.9e-200 I acyl-CoA dehydrogenase
AAKFIGLK_00501 2e-97 mip S hydroperoxide reductase activity
AAKFIGLK_00502 2.3e-251 rumA 2.1.1.190 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AAKFIGLK_00503 5.1e-78 P Mediates zinc uptake. May also transport other divalent cations
AAKFIGLK_00504 2.4e-51 zupT P Mediates zinc uptake. May also transport other divalent cations
AAKFIGLK_00505 1.6e-61 smtB K Transcriptional regulator
AAKFIGLK_00506 0.0 cadA 3.6.3.3, 3.6.3.5 P COG2217 Cation transport ATPase
AAKFIGLK_00507 4.3e-22
AAKFIGLK_00508 2e-217 EGP Transmembrane secretion effector
AAKFIGLK_00509 1e-257 yheS_2 S ATPase components of ABC transporters with duplicated ATPase domains
AAKFIGLK_00510 1.1e-49
AAKFIGLK_00511 8.7e-60
AAKFIGLK_00512 5.9e-55
AAKFIGLK_00513 1.5e-36 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AAKFIGLK_00514 5.7e-112 K Bacterial regulatory proteins, tetR family
AAKFIGLK_00515 2.3e-104 S ABC-type transport system involved in multi-copper enzyme maturation, permease component
AAKFIGLK_00516 9.3e-130 bcrA V abc transporter atp-binding protein
AAKFIGLK_00517 7e-290 V ABC transporter transmembrane region
AAKFIGLK_00518 1.7e-12
AAKFIGLK_00519 8.8e-139 S hydrolases or acyltransferases (alpha beta hydrolase superfamily)
AAKFIGLK_00520 5.3e-141 S Domain of unknown function (DUF4336)
AAKFIGLK_00521 1.5e-203 yeaN P transporter
AAKFIGLK_00522 7.8e-149 yitS S EDD domain protein, DegV family
AAKFIGLK_00523 2.6e-95 XK27_08140 K Bacterial regulatory proteins, tetR family
AAKFIGLK_00524 8.1e-114 cutC P Participates in the control of copper homeostasis
AAKFIGLK_00526 3e-19 S Domain of unknown function (DUF4767)
AAKFIGLK_00527 5.6e-282 norB P Major facilitator superfamily
AAKFIGLK_00528 6.3e-91 tetR K transcriptional regulator
AAKFIGLK_00529 9.2e-150 S Domain of unknown function (DUF4300)
AAKFIGLK_00530 5e-115 V CAAX protease self-immunity
AAKFIGLK_00531 1.5e-157 fecD P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AAKFIGLK_00532 8.3e-134 fecE 3.6.3.34 HP ABC transporter
AAKFIGLK_00533 7.7e-175 fatB P COG0614 ABC-type Fe3 -hydroxamate transport system, periplasmic component
AAKFIGLK_00534 8.4e-125 ybbA S Putative esterase
AAKFIGLK_00535 3.7e-157 yegS 2.7.1.107 I Diacylglycerol kinase
AAKFIGLK_00536 6.8e-171 S Domain of unknown function (DUF389)
AAKFIGLK_00538 2.3e-29 S Membrane
AAKFIGLK_00539 4.7e-97
AAKFIGLK_00540 1.5e-22 S Small integral membrane protein
AAKFIGLK_00541 7.7e-68 S Asp23 family, cell envelope-related function
AAKFIGLK_00542 3.3e-08 K CsbD-like
AAKFIGLK_00543 7.8e-10 S CsbD-like
AAKFIGLK_00544 3.3e-173 pdhD 1.8.1.4 C Dehydrogenase
AAKFIGLK_00545 3.6e-167 acoA C Acetoin dehydrogenase E1 component subunit alpha
AAKFIGLK_00546 1.3e-174 acoB C dehydrogenase E1 component
AAKFIGLK_00547 2.7e-142 acoC 2.3.1.12, 2.3.1.61 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
AAKFIGLK_00548 1.1e-80 Q Methyltransferase domain
AAKFIGLK_00549 1.3e-73 K TetR family transcriptional regulator
AAKFIGLK_00550 7.9e-46
AAKFIGLK_00551 2.8e-129 V CAAX protease self-immunity
AAKFIGLK_00552 1.3e-09
AAKFIGLK_00553 6.9e-21 M Bacterial lipoprotein
AAKFIGLK_00554 1.7e-61 S Protein of unknown function (DUF1722)
AAKFIGLK_00555 3.7e-63 yqeB S Pyrimidine dimer DNA glycosylase
AAKFIGLK_00557 5.5e-51
AAKFIGLK_00558 4.4e-93 S CAAX protease self-immunity
AAKFIGLK_00559 9.6e-115 estA E GDSL-like Lipase/Acylhydrolase
AAKFIGLK_00560 4.4e-101
AAKFIGLK_00561 2.4e-287 sulP P Sulfate permease and related transporters (MFS superfamily)
AAKFIGLK_00562 3.8e-148 ycgQ S TIGR03943 family
AAKFIGLK_00563 1.9e-156 XK27_03015 S permease
AAKFIGLK_00565 0.0 yhgF K Transcriptional accessory protein
AAKFIGLK_00566 2.9e-41 pspC KT PspC domain
AAKFIGLK_00567 5.4e-167 hprK F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AAKFIGLK_00568 9.9e-146 lgt 2.1.1.199 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AAKFIGLK_00569 3.7e-08 WQ51_05790 S protein containing a divergent version of the methyl-accepting chemotaxis-like domain
AAKFIGLK_00570 3e-67 ytxH S General stress protein
AAKFIGLK_00571 0.0 ftsH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AAKFIGLK_00572 2e-97 hpt 2.4.2.8, 6.3.4.19 F Belongs to the purine pyrimidine phosphoribosyltransferase family
AAKFIGLK_00573 7.7e-233 tilS 2.4.2.8, 6.3.4.19 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
AAKFIGLK_00574 3.2e-234 XK27_09285 3.5.2.6 V Beta-lactamase enzyme family
AAKFIGLK_00576 3e-60 divIC D Septum formation initiator
AAKFIGLK_00577 2.2e-39 yabO J Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
AAKFIGLK_00578 0.0 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AAKFIGLK_00579 5.2e-104 pth 3.1.1.29 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
AAKFIGLK_00580 1.1e-203 ychF J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
AAKFIGLK_00581 3.2e-29 yyzM S Protein conserved in bacteria
AAKFIGLK_00582 4.2e-198 dnaN 2.7.7.7 L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
AAKFIGLK_00583 3.2e-253 dnaA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AAKFIGLK_00584 3.2e-133 parB K Belongs to the ParB family
AAKFIGLK_00585 1.5e-201 htrA 3.4.21.107 O Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain'
AAKFIGLK_00586 6.8e-81 rlmH 2.1.1.177 J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AAKFIGLK_00587 2.2e-117 yoaK S Protein of unknown function (DUF1275)
AAKFIGLK_00591 0.0 XK27_10405 S Bacterial membrane protein YfhO
AAKFIGLK_00592 1.1e-305 ybiT S abc transporter atp-binding protein
AAKFIGLK_00593 9.3e-153 yvjA S membrane
AAKFIGLK_00594 7.2e-189 trpS 6.1.1.2 J Tryptophanyl-tRNA synthetase
AAKFIGLK_00595 1.1e-273 guaB 1.1.1.205 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
AAKFIGLK_00596 1.2e-200 recF L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AAKFIGLK_00597 6.4e-58 yaaA S S4 domain protein YaaA
AAKFIGLK_00598 5.6e-228 ymfF S Peptidase M16
AAKFIGLK_00599 2e-233 ymfH S Peptidase M16
AAKFIGLK_00600 5.4e-129 S sequence-specific DNA binding
AAKFIGLK_00601 5.9e-89 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AAKFIGLK_00602 7.7e-149 ecfA1 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AAKFIGLK_00603 1.4e-150 ecfA2 3.6.3.55 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AAKFIGLK_00604 2.4e-131 ecfT P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AAKFIGLK_00605 1.9e-61 lytE M LysM domain protein
AAKFIGLK_00606 9.3e-63 isaA GH23 M Immunodominant staphylococcal antigen A
AAKFIGLK_00607 2.1e-305 S Bacterial membrane protein, YfhO
AAKFIGLK_00608 5.6e-219 mnmA 2.8.1.13 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
AAKFIGLK_00609 2.5e-96 yvbG U UPF0056 membrane protein
AAKFIGLK_00610 0.0 gidA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
AAKFIGLK_00611 0.0 yybT T signaling protein consisting of a modified GGDEF domain and a DHH domain
AAKFIGLK_00612 2.2e-73 rplI J binds to the 23S rRNA
AAKFIGLK_00613 5.5e-245 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
AAKFIGLK_00614 1.8e-47 veg S Biofilm formation stimulator VEG
AAKFIGLK_00615 5.8e-109 rpsD J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AAKFIGLK_00616 7.2e-185 sip L Belongs to the 'phage' integrase family
AAKFIGLK_00617 4.8e-20 K Helix-turn-helix XRE-family like proteins
AAKFIGLK_00618 1.4e-19 K TRANSCRIPTIONal
AAKFIGLK_00622 1.9e-13
AAKFIGLK_00623 2e-21
AAKFIGLK_00624 3.5e-136 KL Phage plasmid primase P4 family
AAKFIGLK_00625 1.8e-257 S DNA primase
AAKFIGLK_00627 1.7e-22 arpU S Transcriptional regulator, ArpU family
AAKFIGLK_00628 1.3e-26
AAKFIGLK_00629 1.4e-149 V Abi-like protein
AAKFIGLK_00631 1.1e-10
AAKFIGLK_00632 2.2e-52 ypaA M Membrane
AAKFIGLK_00633 1.3e-93 XK27_06935 K transcriptional regulator
AAKFIGLK_00634 3.9e-161 XK27_06930 V domain protein
AAKFIGLK_00635 1.6e-101 S Putative adhesin
AAKFIGLK_00636 4e-59 XK27_06920 S Protein of unknown function (DUF1700)
AAKFIGLK_00637 5e-51 K transcriptional regulator, PadR family
AAKFIGLK_00638 3.8e-113 nudL L hydrolase
AAKFIGLK_00641 3.3e-07
AAKFIGLK_00642 6.7e-19 rpmG J Belongs to the bacterial ribosomal protein bL33 family
AAKFIGLK_00643 3.4e-25 rpmF J Belongs to the bacterial ribosomal protein bL32 family
AAKFIGLK_00644 1.2e-218 metE 2.1.1.14 E Methionine synthase
AAKFIGLK_00645 8e-08 2.7.1.201, 2.7.1.208, 2.7.1.211 G pts system
AAKFIGLK_00646 5.8e-50 2.7.1.201, 2.7.1.208, 2.7.1.211 G pts system
AAKFIGLK_00647 3.9e-73 2.7.1.201, 2.7.1.208, 2.7.1.211 G pts system
AAKFIGLK_00648 8e-238 hisS 6.1.1.21 J histidyl-tRNA synthetase
AAKFIGLK_00650 0.0 aspS 6.1.1.12 J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
AAKFIGLK_00651 9.3e-167 XK27_01785 S cog cog1284
AAKFIGLK_00652 6.9e-119 yaaA S Belongs to the UPF0246 family
AAKFIGLK_00653 1.5e-114 nrdG 1.97.1.4 O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AAKFIGLK_00654 7.3e-86 XK27_10930 K acetyltransferase
AAKFIGLK_00655 7.5e-14
AAKFIGLK_00656 0.0 nrdD 1.1.98.6 F Ribonucleoside-triphosphate reductase
AAKFIGLK_00657 1.3e-288 ccs S the current gene model (or a revised gene model) may contain a frame shift
AAKFIGLK_00658 3.2e-44 yrzB S Belongs to the UPF0473 family
AAKFIGLK_00659 1.8e-69 yqgF L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AAKFIGLK_00660 6.3e-44 yrzL S Belongs to the UPF0297 family
AAKFIGLK_00661 8.4e-27 rpmB J Belongs to the bacterial ribosomal protein bL28 family
AAKFIGLK_00662 8.2e-235 rarA L ATPase related to the helicase subunit of the Holliday junction resolvase
AAKFIGLK_00664 2.9e-90 adk 2.7.4.3 F topology modulation protein
AAKFIGLK_00665 4.1e-250 purA 6.3.4.4 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AAKFIGLK_00666 1.4e-80 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AAKFIGLK_00667 2.8e-35 XK27_09805 S MORN repeat protein
AAKFIGLK_00668 0.0 XK27_09800 I Acyltransferase
AAKFIGLK_00669 1e-187 ruvB 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
AAKFIGLK_00670 2.9e-48 rpsJ J Involved in the binding of tRNA to the ribosomes
AAKFIGLK_00671 2.4e-110 rplC J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AAKFIGLK_00672 5.7e-104 rplD J Forms part of the polypeptide exit tunnel
AAKFIGLK_00673 2.4e-44 rplW J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
AAKFIGLK_00674 6.8e-153 rplB J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AAKFIGLK_00675 8.3e-47 rpsS J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AAKFIGLK_00676 7.3e-53 rplV J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AAKFIGLK_00677 1.6e-117 rpsC J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AAKFIGLK_00678 1.1e-71 rplP J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AAKFIGLK_00679 3.5e-26 rpmC J Belongs to the universal ribosomal protein uL29 family
AAKFIGLK_00680 6e-39 rpsQ J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AAKFIGLK_00681 3.9e-60 rplN J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AAKFIGLK_00682 1.4e-47 rplX J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AAKFIGLK_00683 1.6e-94 rplE J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AAKFIGLK_00684 6.3e-168 cysK 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
AAKFIGLK_00685 2.9e-108 yvyE 3.4.13.9 S YigZ family
AAKFIGLK_00686 5.7e-239 comFA L Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AAKFIGLK_00687 6.5e-98 comFC K competence protein
AAKFIGLK_00688 1.6e-94 hpf J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AAKFIGLK_00689 2.8e-226 tgt 2.4.2.29 F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
AAKFIGLK_00690 3.4e-14 rpmH J Ribosomal protein L34
AAKFIGLK_00691 6.1e-97 1.6.5.2 S NADPH-quinone reductase (modulator of drug activity B)
AAKFIGLK_00692 2e-98 K Transcriptional regulator
AAKFIGLK_00693 1e-169 jag S RNA-binding protein
AAKFIGLK_00694 8.3e-140 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
AAKFIGLK_00695 1.3e-54 rnpA 3.1.26.5 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
AAKFIGLK_00696 1.6e-263 argH 4.3.2.1 E Argininosuccinate lyase
AAKFIGLK_00697 1.4e-228 argG 6.3.4.5 E Belongs to the argininosuccinate synthase family. Type 1 subfamily
AAKFIGLK_00698 1.6e-129 fasA KT Response regulator of the LytR AlgR family
AAKFIGLK_00699 8e-225 fasC 2.7.13.3 T protein histidine kinase activity
AAKFIGLK_00700 1.9e-207 hpk9 2.7.13.3 T protein histidine kinase activity
AAKFIGLK_00701 1.2e-150 hpk9 2.7.13.3 T protein histidine kinase activity
AAKFIGLK_00702 1.4e-229 2.7.13.3 T signal transduction protein with a C-terminal ATPase domain
AAKFIGLK_00703 1.8e-273 gltX 6.1.1.17, 6.1.1.24 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AAKFIGLK_00704 0.0 amiA E ABC transporter, substrate-binding protein, family 5
AAKFIGLK_00705 1.4e-119 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
AAKFIGLK_00706 3.7e-70 rplK J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AAKFIGLK_00707 1.6e-50 S Protein of unknown function (DUF3397)
AAKFIGLK_00708 1e-87 cah 4.2.1.1 P Reversible hydration of carbon dioxide
AAKFIGLK_00709 1.6e-126 WQ51_05710 S Mitochondrial biogenesis AIM24
AAKFIGLK_00710 2e-225 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AAKFIGLK_00711 2.7e-75 3.5.1.19 Q hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
AAKFIGLK_00712 2e-79 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
AAKFIGLK_00713 6.3e-108 XK27_09620 S FMN reductase (NADPH) activity
AAKFIGLK_00714 1.3e-229 XK27_09615 C reductase
AAKFIGLK_00715 2.4e-139 fnt P Formate nitrite transporter
AAKFIGLK_00716 1.8e-96 XK27_08585 S Psort location CytoplasmicMembrane, score
AAKFIGLK_00717 8.2e-185 gpsA 1.1.1.94 I Glycerol-3-phosphate dehydrogenase
AAKFIGLK_00718 1.6e-168 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
AAKFIGLK_00719 1.1e-116 gluP 3.4.21.105 O membrane protein (homolog of Drosophila rhomboid)
AAKFIGLK_00720 2.9e-93 ygfA 6.3.3.2 H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AAKFIGLK_00721 7.4e-219 hipO 3.5.1.47 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
AAKFIGLK_00722 5.3e-58 dapD 2.3.1.117, 2.3.1.89 E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
AAKFIGLK_00723 1.3e-126 S HAD hydrolase, family IA, variant
AAKFIGLK_00724 1.9e-155 rrmA 2.1.1.187 Q methyltransferase
AAKFIGLK_00728 2.1e-88 tadA 3.5.4.1, 3.5.4.33 FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
AAKFIGLK_00729 6.6e-66 ssb_2 L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
AAKFIGLK_00730 8.3e-37 yeeD O sulfur carrier activity
AAKFIGLK_00731 4e-187 yeeE S Sulphur transport
AAKFIGLK_00732 5.1e-113 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
AAKFIGLK_00733 2e-09 S NTF2 fold immunity protein
AAKFIGLK_00734 3.6e-54 ytpP 2.7.1.180, 5.3.4.1 CO Thioredoxin
AAKFIGLK_00735 4.6e-08 S Domain of unknown function (DUF4651)
AAKFIGLK_00736 1.4e-203 pepA 3.4.11.7 G COG1363 Cellulase M and related proteins
AAKFIGLK_00737 8.2e-129 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AAKFIGLK_00738 1.5e-94 S CAAX amino terminal protease family protein
AAKFIGLK_00740 8.4e-98 V CAAX protease self-immunity
AAKFIGLK_00741 4.4e-26 lanR K sequence-specific DNA binding
AAKFIGLK_00742 6e-219 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AAKFIGLK_00743 5e-176 ytxK 2.1.1.72 L DNA methylase
AAKFIGLK_00744 2e-12 comGF U Putative Competence protein ComGF
AAKFIGLK_00745 2e-71 comGF U Competence protein ComGF
AAKFIGLK_00746 5.3e-15 NU Type II secretory pathway pseudopilin
AAKFIGLK_00747 1.1e-69 cglD NU Competence protein
AAKFIGLK_00748 2.2e-43 comGC U Required for transformation and DNA binding
AAKFIGLK_00749 2.2e-143 comGA NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AAKFIGLK_00750 4.2e-175 comGA NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AAKFIGLK_00751 5e-68 S cog cog4699
AAKFIGLK_00752 0.0 rpoC 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AAKFIGLK_00753 0.0 rpoB 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AAKFIGLK_00754 0.0 pbp1B 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
AAKFIGLK_00755 5.5e-239 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AAKFIGLK_00756 1.3e-193 ilvC 1.1.1.86 H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AAKFIGLK_00757 2.2e-76 ilvN 2.2.1.6 E Acetolactate synthase
AAKFIGLK_00758 0.0 ilvB 2.2.1.6 EH Acetolactate synthase
AAKFIGLK_00759 0.0 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
AAKFIGLK_00760 2.1e-302 yloV S kinase related to dihydroxyacetone kinase
AAKFIGLK_00761 1.4e-57 asp S cog cog1302
AAKFIGLK_00762 2.8e-222 norN V Mate efflux family protein
AAKFIGLK_00763 1.9e-275 thrC 4.2.3.1 E Threonine synthase
AAKFIGLK_00766 0.0 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
AAKFIGLK_00767 0.0 pepO 3.4.24.71 O Peptidase family M13
AAKFIGLK_00768 1.8e-181 treC 3.2.1.93 GH13 G COG0366 Glycosidases
AAKFIGLK_00769 1.4e-43 treR K trehalose operon
AAKFIGLK_00770 1.9e-95 ywlG S Belongs to the UPF0340 family
AAKFIGLK_00772 1.3e-165 fba 4.1.2.13, 4.1.2.29 G aldolase
AAKFIGLK_00774 9.9e-244 6.3.2.2 H gamma-glutamylcysteine synthetase
AAKFIGLK_00775 4.4e-62 rplQ J ribosomal protein l17
AAKFIGLK_00776 3.6e-171 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AAKFIGLK_00777 1.9e-62 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AAKFIGLK_00778 4.4e-56 rpsM J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AAKFIGLK_00779 6e-15 rpmJ J Belongs to the bacterial ribosomal protein bL36 family
AAKFIGLK_00780 2.7e-32 infA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AAKFIGLK_00781 4.7e-114 adk 2.7.4.3 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
AAKFIGLK_00782 2.1e-230 secY U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
AAKFIGLK_00783 5.7e-58 rplO J binds to the 23S rRNA
AAKFIGLK_00784 1.9e-23 rpmD J ribosomal protein l30
AAKFIGLK_00785 1.3e-79 rpsE J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AAKFIGLK_00786 1.9e-56 rplR J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AAKFIGLK_00787 6.6e-93 rplF J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AAKFIGLK_00788 1.2e-67 rpsH J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AAKFIGLK_00789 1.5e-28 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AAKFIGLK_00792 1.1e-162 ppaC 3.6.1.1 C inorganic pyrophosphatase
AAKFIGLK_00793 2.8e-103 S Domain of unknown function (DUF1803)
AAKFIGLK_00794 7.8e-102 ygaC J Belongs to the UPF0374 family
AAKFIGLK_00795 4.1e-136 recX 2.4.1.337 GT4 S Regulatory protein RecX
AAKFIGLK_00796 2.6e-247 rumA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AAKFIGLK_00797 1.4e-192 asnA 6.3.1.1 E aspartate--ammonia ligase
AAKFIGLK_00798 8.2e-257 lysC 2.7.2.4 E Belongs to the aspartokinase family
AAKFIGLK_00799 2.8e-114 S HAD hydrolase, family IA, variant 3
AAKFIGLK_00800 4.8e-140 phaB 5.3.3.14, 5.3.3.18 I Belongs to the enoyl-CoA hydratase isomerase family
AAKFIGLK_00801 5.2e-72 marR K Transcriptional regulator, MarR family
AAKFIGLK_00802 1.4e-170 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AAKFIGLK_00803 3.3e-30 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
AAKFIGLK_00804 9.9e-172 fabK 1.3.1.9 S 2-Nitropropane dioxygenase
AAKFIGLK_00805 7.2e-164 fabD 2.3.1.39 I Malonyl CoA-acyl carrier protein transacylase
AAKFIGLK_00806 6.2e-126 IQ reductase
AAKFIGLK_00807 2.6e-233 fabF 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
AAKFIGLK_00808 9.4e-54 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
AAKFIGLK_00809 1.5e-71 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
AAKFIGLK_00810 3.5e-255 accC 6.3.4.14, 6.4.1.2 I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
AAKFIGLK_00811 3.9e-159 accD 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AAKFIGLK_00812 1.8e-139 accA 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
AAKFIGLK_00813 4.7e-90 luxS 4.4.1.21 H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
AAKFIGLK_00814 5.4e-207 rny D Endoribonuclease that initiates mRNA decay
AAKFIGLK_00815 3.1e-125 fruR K transcriptional
AAKFIGLK_00816 7.6e-166 pfkB 2.7.1.11, 2.7.1.56 H Belongs to the carbohydrate kinase PfkB family. LacC subfamily
AAKFIGLK_00817 0.0 fruA 2.7.1.202 G phosphotransferase system
AAKFIGLK_00818 5.9e-255 gor 1.8.1.7 C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AAKFIGLK_00819 1.2e-225 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
AAKFIGLK_00821 1.7e-210 iscS2 2.8.1.7 E Cysteine sulfinate desulfinase cysteine desulfurase and related enzymes
AAKFIGLK_00822 2.2e-224 thiI 2.8.1.4 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AAKFIGLK_00823 2.2e-290 gtf1 2.4.1.52 GT4 M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
AAKFIGLK_00824 7e-253 gtf2 M A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1
AAKFIGLK_00825 6.2e-83 2.3.1.128 K acetyltransferase
AAKFIGLK_00826 4.5e-49 rplU J This protein binds to 23S rRNA in the presence of protein L20
AAKFIGLK_00827 1.5e-46 rpmA J Belongs to the bacterial ribosomal protein bL27 family
AAKFIGLK_00828 1.1e-132 ydaF_2 J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AAKFIGLK_00829 5e-63 WQ51_03320 S cog cog4835
AAKFIGLK_00830 2.8e-146 XK27_08360 S EDD domain protein, DegV family
AAKFIGLK_00831 2.5e-138 dapB 1.17.1.8 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
AAKFIGLK_00832 1.7e-218 cca 2.7.7.19, 2.7.7.72 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
AAKFIGLK_00833 0.0 yfmR S abc transporter atp-binding protein
AAKFIGLK_00834 5e-26 U response to pH
AAKFIGLK_00835 2.4e-128 3.6.1.13, 3.6.1.55 F AdP-ribose pyrophosphatase
AAKFIGLK_00836 1.8e-43 nadD 2.7.1.22, 2.7.7.1, 2.7.7.18, 3.6.1.55 H adenylyltransferase
AAKFIGLK_00837 1e-153 nadD 2.7.1.22, 2.7.7.1, 2.7.7.18, 3.6.1.55 H adenylyltransferase
AAKFIGLK_00838 1.4e-256 gdhA 1.4.1.4 E Belongs to the Glu Leu Phe Val dehydrogenases family
AAKFIGLK_00839 1.9e-268 S Psort location CytoplasmicMembrane, score
AAKFIGLK_00840 3e-69 def_1 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins
AAKFIGLK_00841 4.4e-74 K DNA-binding transcription factor activity
AAKFIGLK_00842 8.3e-291 lmrA1 V abc transporter atp-binding protein
AAKFIGLK_00843 0.0 lmrA2 V abc transporter atp-binding protein
AAKFIGLK_00844 2.6e-109 K Acetyltransferase (GNAT) family
AAKFIGLK_00845 2.8e-111 2.7.6.5 S Region found in RelA / SpoT proteins
AAKFIGLK_00846 2.7e-115 T response regulator
AAKFIGLK_00847 4.4e-209 sptS 2.7.13.3 T Histidine kinase
AAKFIGLK_00848 1.7e-131 pyrH 2.7.4.22 F Catalyzes the reversible phosphorylation of UMP to UDP
AAKFIGLK_00849 6.4e-91 frr J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
AAKFIGLK_00850 8.5e-159 cvfB S Protein conserved in bacteria
AAKFIGLK_00851 3.7e-34 yozE S Belongs to the UPF0346 family
AAKFIGLK_00852 3.9e-128 sip M LysM domain protein
AAKFIGLK_00853 1.4e-187 phoH T phosphate starvation-inducible protein PhoH
AAKFIGLK_00859 0.0 metG 6.1.1.10, 6.1.1.20 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AAKFIGLK_00860 2.9e-159 S reductase
AAKFIGLK_00861 5.2e-167 K transcriptional regulator (lysR family)
AAKFIGLK_00862 1e-104 S CAAX amino terminal protease family protein
AAKFIGLK_00863 6.4e-279 2.7.13.3, 2.7.7.7, 5.4.99.21 D Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AAKFIGLK_00864 5.2e-165 coiA 3.6.4.12 S Competence protein
AAKFIGLK_00865 0.0 pepF E oligoendopeptidase F
AAKFIGLK_00866 5.9e-214 oxlT P COG0477 Permeases of the major facilitator superfamily
AAKFIGLK_00867 6.7e-119 yrrM 2.1.1.104 S O-Methyltransferase
AAKFIGLK_00868 3e-167 prsA 3.1.3.16, 5.2.1.8 O peptidyl-prolyl cis-trans isomerase activity
AAKFIGLK_00869 3e-84 yxjI S LURP-one-related
AAKFIGLK_00870 0.0 alaS 6.1.1.7 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AAKFIGLK_00873 0.0 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
AAKFIGLK_00874 1.3e-131 agrA KT phosphorelay signal transduction system
AAKFIGLK_00875 1.3e-227 2.7.13.3 T GHKL domain
AAKFIGLK_00878 2.8e-100 desR K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
AAKFIGLK_00879 9.4e-179 desK 2.7.13.3 T Histidine kinase
AAKFIGLK_00880 1.5e-132 yvfS V ABC-2 type transporter
AAKFIGLK_00881 7.9e-160 XK27_09825 V abc transporter atp-binding protein
AAKFIGLK_00884 6.2e-171 fabH 2.3.1.180 I synthase III
AAKFIGLK_00885 3.6e-238 6.2.1.30 H Coenzyme F390 synthetase
AAKFIGLK_00886 6e-154 gumP S Metallo-beta-lactamase superfamily
AAKFIGLK_00887 5.9e-180 ybjS 1.1.1.133, 5.1.3.13 M NAD dependent epimerase dehydratase family protein
AAKFIGLK_00888 3.5e-233 2.4.1.276 GT1 CG Glycosyltransferase family 28 C-terminal domain
AAKFIGLK_00889 3.5e-95 1.1.1.105 S Belongs to the short-chain dehydrogenases reductases (SDR) family
AAKFIGLK_00890 1.8e-193 ugcG 2.4.1.80 GT21 M transferase activity, transferring glycosyl groups
AAKFIGLK_00891 2e-99
AAKFIGLK_00892 1.5e-207 2.4.1.276 GT1 CG transferase activity, transferring hexosyl groups
AAKFIGLK_00894 1.8e-235 anK3 G response to abiotic stimulus
AAKFIGLK_00895 0.0 hscC O Belongs to the heat shock protein 70 family
AAKFIGLK_00896 7.3e-164 yocS S Transporter
AAKFIGLK_00897 2.2e-81 cdd 2.4.2.4, 3.5.4.5 F cytidine deaminase activity
AAKFIGLK_00898 1.2e-116 yvfS V Transporter
AAKFIGLK_00899 2.4e-156 XK27_09825 V abc transporter atp-binding protein
AAKFIGLK_00900 8.3e-16 liaI KT membrane
AAKFIGLK_00901 3.4e-30 liaI KT membrane
AAKFIGLK_00902 6.8e-92 XK27_05000 S metal cluster binding
AAKFIGLK_00903 0.0 V ABC transporter (permease)
AAKFIGLK_00904 3.2e-133 macB2 V ABC transporter, ATP-binding protein
AAKFIGLK_00905 1.8e-160 T Histidine kinase
AAKFIGLK_00906 5.4e-124 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
AAKFIGLK_00907 6.7e-99 xpt 2.4.2.22, 2.4.2.7 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
AAKFIGLK_00908 2.1e-222 pbuX F xanthine permease
AAKFIGLK_00909 6.7e-243 norM V Multidrug efflux pump
AAKFIGLK_00911 8.8e-181 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AAKFIGLK_00912 2.8e-233 brnQ E Component of the transport system for branched-chain amino acids
AAKFIGLK_00913 1.7e-181 manA 5.3.1.8 G mannose-6-phosphate isomerase
AAKFIGLK_00914 1.8e-59 S Protein of unknown function (DUF3290)
AAKFIGLK_00915 3.4e-104 S Protein of unknown function (DUF421)
AAKFIGLK_00916 1.1e-16 csbD S CsbD-like
AAKFIGLK_00917 1.5e-115 S Carbohydrate-binding domain-containing protein Cthe_2159
AAKFIGLK_00918 1.7e-27 S Carbohydrate-binding domain-containing protein Cthe_2159
AAKFIGLK_00919 7.5e-50 XK27_01300 P Protein conserved in bacteria
AAKFIGLK_00920 5.1e-222 yfnA E amino acid
AAKFIGLK_00921 0.0 S dextransucrase activity
AAKFIGLK_00922 6.6e-84 btuE 1.11.1.9 O Belongs to the glutathione peroxidase family
AAKFIGLK_00923 1.5e-42 S Sugar efflux transporter for intercellular exchange
AAKFIGLK_00924 3e-204 P FtsX-like permease family
AAKFIGLK_00925 6e-123 V abc transporter atp-binding protein
AAKFIGLK_00926 1.1e-96 K WHG domain
AAKFIGLK_00927 7.5e-169 ydhF S Aldo keto reductase
AAKFIGLK_00928 4.9e-07 S Protein of unknown function (DUF3169)
AAKFIGLK_00929 2.5e-27 XK27_07105 K transcriptional
AAKFIGLK_00930 2.8e-35
AAKFIGLK_00931 8.7e-110 XK27_02070 S nitroreductase
AAKFIGLK_00932 8.2e-149 1.13.11.2 S glyoxalase
AAKFIGLK_00933 1.5e-74 ywnA K Transcriptional regulator
AAKFIGLK_00934 9.2e-153 E Alpha/beta hydrolase of unknown function (DUF915)
AAKFIGLK_00935 5.6e-223 pts13C G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
AAKFIGLK_00936 2.4e-167 bcrA V abc transporter atp-binding protein
AAKFIGLK_00937 4.4e-127 S ABC-2 family transporter protein
AAKFIGLK_00938 6.3e-93 S Psort location Cytoplasmic, score
AAKFIGLK_00939 4.8e-149 T PhoQ Sensor
AAKFIGLK_00940 2.1e-123 T Xre family transcriptional regulator
AAKFIGLK_00941 1.7e-111 drgA C nitroreductase
AAKFIGLK_00942 1.6e-104 yoaK S Protein of unknown function (DUF1275)
AAKFIGLK_00943 4e-40 DJ nuclease activity
AAKFIGLK_00944 1.9e-30 XK27_10490
AAKFIGLK_00945 3.7e-159 yvgN C reductase
AAKFIGLK_00946 1.4e-209 S Tetratricopeptide repeat
AAKFIGLK_00947 0.0 lacL 3.2.1.23 G -beta-galactosidase
AAKFIGLK_00948 0.0 lacS G transporter
AAKFIGLK_00949 1.4e-200 galM 5.1.3.3 G Catalyzes the interconversion of alpha and beta anomers of maltose
AAKFIGLK_00950 1.1e-194 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
AAKFIGLK_00951 9.8e-288 galT 2.7.7.12 G UDPglucose--hexose-1-phosphate uridylyltransferase
AAKFIGLK_00952 2.1e-221 galK 2.7.1.6 G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AAKFIGLK_00953 3.2e-181 galR K Transcriptional regulator
AAKFIGLK_00954 1.2e-307 dexB 3.2.1.10, 3.2.1.70 GH13 G COG0366 Glycosidases
AAKFIGLK_00955 3.1e-221 vncS 2.7.13.3 T Histidine kinase
AAKFIGLK_00956 5.2e-116 K Response regulator receiver domain protein
AAKFIGLK_00957 2.3e-238 vex3 V Efflux ABC transporter, permease protein
AAKFIGLK_00958 1.9e-107 vex2 V abc transporter atp-binding protein
AAKFIGLK_00959 5.4e-202 vex1 V Efflux ABC transporter, permease protein
AAKFIGLK_00960 5e-284 XK27_07020 S Belongs to the UPF0371 family
AAKFIGLK_00962 1.3e-160 BP1961 P oxidoreductase
AAKFIGLK_00963 1.2e-32 BP1961 P oxidoreductase
AAKFIGLK_00964 5.3e-181 XK27_10475 S oxidoreductase
AAKFIGLK_00965 2.2e-58 dhaM 2.7.1.121 S dihydroxyacetone kinase, phosphotransfer subunit
AAKFIGLK_00966 2.9e-94 dhaL 2.7.1.121 S Dihydroxyacetone kinase
AAKFIGLK_00967 1.7e-179 dhaK 2.7.1.121, 2.7.1.28, 2.7.1.29, 4.6.1.15 G Dihydroxyacetone kinase
AAKFIGLK_00968 2.2e-224 thrE K Psort location CytoplasmicMembrane, score
AAKFIGLK_00969 4.6e-222 vanY 3.4.17.14, 3.5.1.28 M D-alanyl-D-alanine carboxypeptidase
AAKFIGLK_00970 9.2e-136 cnhA 3.5.1.3 S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
AAKFIGLK_00971 5.7e-222 mtnE 2.6.1.83 E mutations do not affect methionine salvage in vivo however
AAKFIGLK_00972 3.8e-182 argC 1.2.1.38 E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AAKFIGLK_00973 9e-31 argJ 2.3.1.1, 2.3.1.35, 2.7.2.8 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AAKFIGLK_00974 2.5e-164 argJ 2.3.1.1, 2.3.1.35, 2.7.2.8 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AAKFIGLK_00975 1.2e-124 argB 2.7.2.8 E Belongs to the acetylglutamate kinase family. ArgB subfamily
AAKFIGLK_00976 3.7e-202 argD 2.6.1.11, 2.6.1.17 E acetylornithine aminotransferase
AAKFIGLK_00977 2.1e-136 yxkH G deacetylase
AAKFIGLK_00978 2.6e-236 hom 1.1.1.3, 2.7.2.4 E homoserine dehydrogenase
AAKFIGLK_00979 5.9e-152 thrB 2.7.1.39 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
AAKFIGLK_00980 2e-147 rarD S Transporter
AAKFIGLK_00981 4e-17 T peptidase
AAKFIGLK_00982 1.4e-14 coiA 3.6.4.12 S Competence protein
AAKFIGLK_00985 4e-104 S COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AAKFIGLK_00986 3e-96 2.3.1.128, 5.2.1.8 J Acetyltransferase (GNAT) domain
AAKFIGLK_00987 1.5e-95 F AAA domain
AAKFIGLK_00988 0.0 valS 6.1.1.9 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
AAKFIGLK_00989 2.4e-16 atpE C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AAKFIGLK_00990 9e-122 atpB C it plays a direct role in the translocation of protons across the membrane
AAKFIGLK_00991 1.6e-77 atpF C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AAKFIGLK_00992 1e-85 atpH C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AAKFIGLK_00993 6.5e-279 atpA 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AAKFIGLK_00994 6.2e-157 atpG C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AAKFIGLK_00995 6.7e-262 atpD 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AAKFIGLK_00996 2.6e-68 atpC C Produces ATP from ADP in the presence of a proton gradient across the membrane
AAKFIGLK_00997 2.7e-217 ftsW D Belongs to the SEDS family
AAKFIGLK_00998 1.6e-224 tuf J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AAKFIGLK_00999 2.6e-135 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
AAKFIGLK_01000 0.0 tkt 2.2.1.1 G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AAKFIGLK_01002 1e-108 tmk 2.7.4.9 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AAKFIGLK_01003 1.6e-160 holB 2.7.7.7 L dna polymerase iii
AAKFIGLK_01004 1.2e-135 yaaT S stage 0 sporulation protein
AAKFIGLK_01005 1.2e-54 yabA L Involved in initiation control of chromosome replication
AAKFIGLK_01006 1.3e-159 rsmI 2.1.1.198 H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AAKFIGLK_01007 3.3e-228 amt P Ammonium Transporter
AAKFIGLK_01008 2.1e-52 glnB K Belongs to the P(II) protein family
AAKFIGLK_01009 1.2e-104 mur1 3.4.17.14, 3.5.1.28 NU amidase activity
AAKFIGLK_01010 1.5e-144 XK27_04800 S Sucrose-6F-phosphate phosphohydrolase
AAKFIGLK_01011 2.6e-75 S Bacterial inner membrane protein
AAKFIGLK_01012 3.4e-112 3.4.17.14, 3.5.1.28 NU amidase activity
AAKFIGLK_01013 7.7e-294 nptA P COG1283 Na phosphate symporter
AAKFIGLK_01014 7.5e-219 nagA 3.5.1.25 G Belongs to the metallo-dependent hydrolases superfamily. NagA family
AAKFIGLK_01015 2.4e-218 S membrane
AAKFIGLK_01016 5.5e-86 soj1 D 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family
AAKFIGLK_01017 2.7e-20
AAKFIGLK_01018 8.5e-176 glyQ 6.1.1.14 J glycyl-tRNA synthetase alpha subunit
AAKFIGLK_01019 0.0 glyS 6.1.1.14 J Glycyl-tRNA synthetase beta subunit
AAKFIGLK_01020 1.7e-38 ynzC S UPF0291 protein
AAKFIGLK_01021 6.7e-254 cycA E permease
AAKFIGLK_01022 7e-09 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AAKFIGLK_01023 0.0 pts33BCA 2.7.1.201, 2.7.1.208, 2.7.1.211 G pts system
AAKFIGLK_01024 3e-139 ppiA 5.2.1.8 O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AAKFIGLK_01028 5.8e-69 K Helix-turn-helix
AAKFIGLK_01029 1.6e-41
AAKFIGLK_01031 1.2e-166 fhuR K transcriptional regulator (lysR family)
AAKFIGLK_01032 2.8e-76 lspA 3.4.23.36 MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AAKFIGLK_01033 1.1e-161 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
AAKFIGLK_01034 1.8e-87 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AAKFIGLK_01035 2.1e-222 pyrP F uracil Permease
AAKFIGLK_01036 1.3e-173 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
AAKFIGLK_01037 4.6e-210 carA 6.3.5.5 F carbamoyl-phosphate synthetase glutamine chain
AAKFIGLK_01038 0.0 carB 6.3.5.5 F carbamoyl-phosphate synthetase ammonia chain
AAKFIGLK_01039 1.6e-124 2.1.1.223 S Putative SAM-dependent methyltransferase
AAKFIGLK_01040 1.2e-180 acrA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AAKFIGLK_01041 1.5e-121 macB V ABC transporter, ATP-binding protein
AAKFIGLK_01042 5.5e-212 V permease protein
AAKFIGLK_01043 5.6e-78 rplJ J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AAKFIGLK_01044 2.1e-45 rplL J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
AAKFIGLK_01047 7.2e-234 2.7.13.3 T GHKL domain
AAKFIGLK_01048 5.3e-133 agrA KT Response regulator of the LytR AlgR family
AAKFIGLK_01050 7.9e-21 S Antitoxin component of a toxin-antitoxin (TA) module
AAKFIGLK_01053 1.9e-07
AAKFIGLK_01058 0.0 polC 2.7.7.7 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AAKFIGLK_01059 3e-237 pepS E COG2309 Leucyl aminopeptidase (aminopeptidase T)
AAKFIGLK_01060 1.2e-35 XK27_02060 S Transglycosylase associated protein
AAKFIGLK_01061 3.9e-72 badR K Transcriptional regulator, marr family
AAKFIGLK_01062 4.4e-92 S reductase
AAKFIGLK_01064 9.8e-283 ahpF O alkyl hydroperoxide reductase
AAKFIGLK_01065 7.9e-105 ahpC 1.11.1.15 O alkyl hydroperoxide reductase
AAKFIGLK_01066 7.4e-138 rpsB J Belongs to the universal ribosomal protein uS2 family
AAKFIGLK_01067 1e-182 tsf J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AAKFIGLK_01068 1.6e-82 S Putative small multi-drug export protein
AAKFIGLK_01069 2e-74 ctsR K Belongs to the CtsR family
AAKFIGLK_01070 0.0 clpC O Belongs to the ClpA ClpB family
AAKFIGLK_01071 1.5e-228 dacA 3.4.16.4 M Belongs to the peptidase S11 family
AAKFIGLK_01072 2e-225 dacA 3.4.16.4 M Belongs to the peptidase S11 family
AAKFIGLK_01073 0.0 pnp 2.7.7.8 J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
AAKFIGLK_01074 3e-139 S SseB protein N-terminal domain
AAKFIGLK_01075 2.5e-112 cysE 2.3.1.30 E serine acetyltransferase
AAKFIGLK_01077 3.4e-255 cysS 6.1.1.16, 6.3.1.13 J Belongs to the class-I aminoacyl-tRNA synthetase family
AAKFIGLK_01078 3.6e-67 mrnC J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AAKFIGLK_01080 9.7e-135 trmH 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AAKFIGLK_01081 1.3e-90 yacP S RNA-binding protein containing a PIN domain
AAKFIGLK_01082 3.8e-151 degV S DegV family
AAKFIGLK_01084 5.1e-22 K Transcriptional
AAKFIGLK_01085 2e-79 rplM J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AAKFIGLK_01086 1.2e-64 rpsI J Belongs to the universal ribosomal protein uS9 family
AAKFIGLK_01087 1.2e-222 int2 L Phage integrase family
AAKFIGLK_01088 1.1e-40 S Helix-turn-helix domain
AAKFIGLK_01089 7.2e-189 L Replication initiation factor
AAKFIGLK_01090 2.6e-36
AAKFIGLK_01092 3.9e-43 K DNA-binding helix-turn-helix protein
AAKFIGLK_01093 5.3e-62 rmeD K Transcriptional regulator
AAKFIGLK_01094 2.4e-31 4.1.1.44 S Carboxymuconolactone decarboxylase family
AAKFIGLK_01095 3.4e-42 S A-factor biosynthesis hotdog domain
AAKFIGLK_01096 5e-47 yhaX S Sucrose-6F-phosphate phosphohydrolase
AAKFIGLK_01097 7.2e-22 5.3.2.6 S Tautomerase enzyme
AAKFIGLK_01098 7.4e-59
AAKFIGLK_01099 1.5e-34 IQ Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases)
AAKFIGLK_01100 6.7e-120 phbA 2.3.1.9 I Thiolase, C-terminal domain
AAKFIGLK_01101 3.4e-135 S Belongs to the short-chain dehydrogenases reductases (SDR) family
AAKFIGLK_01102 1.4e-107 fic D Fic/DOC family
AAKFIGLK_01103 3.4e-28
AAKFIGLK_01104 1.9e-81
AAKFIGLK_01105 1.3e-17
AAKFIGLK_01106 1.5e-29 K Helix-turn-helix domain
AAKFIGLK_01108 8.6e-148 srtB 3.4.22.70 S Sortase family
AAKFIGLK_01109 9.7e-233 capA M Bacterial capsule synthesis protein
AAKFIGLK_01110 2.3e-38 gcvR T UPF0237 protein
AAKFIGLK_01111 2.1e-241 XK27_08635 S UPF0210 protein
AAKFIGLK_01112 4.3e-132 ais G Phosphoglycerate mutase
AAKFIGLK_01113 7e-139 vanY 3.4.17.14 M D-alanyl-D-alanine carboxypeptidase
AAKFIGLK_01114 3.6e-100 acmA 3.2.1.17, 3.4.17.14, 3.5.1.28 NU Muramidase (Flagellum-specific)
AAKFIGLK_01115 3.7e-185 hrcA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
AAKFIGLK_01116 9.1e-63 grpE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AAKFIGLK_01117 1.4e-304 dnaK O Heat shock 70 kDa protein
AAKFIGLK_01118 1.8e-188 dnaJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
AAKFIGLK_01119 9.4e-138 truA 5.4.99.12 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
AAKFIGLK_01120 5.3e-136 thiD 2.7.1.35, 2.7.1.49, 2.7.4.7 H phosphomethylpyrimidine kinase
AAKFIGLK_01121 4.3e-80 hmpT S cog cog4720
AAKFIGLK_01122 3.8e-179 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
AAKFIGLK_01123 0.0 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AAKFIGLK_01124 7.9e-132 srtA 3.4.22.70 M Sortase (surface protein transpeptidase)
AAKFIGLK_01125 4.5e-70 yaeR E COG0346 Lactoylglutathione lyase and related lyases
AAKFIGLK_01126 7.9e-161 ypuA S secreted protein
AAKFIGLK_01127 2.3e-107 mntH P Mn2 and Fe2 transporters of the NRAMP family
AAKFIGLK_01128 1.3e-70 mntH P Mn2 and Fe2 transporters of the NRAMP family
AAKFIGLK_01129 4.4e-45 rpmE2 J 50S ribosomal protein L31
AAKFIGLK_01130 4.9e-168 apbE 2.7.1.180 H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
AAKFIGLK_01131 1.6e-174 nrnA 3.1.13.3, 3.1.3.7 S domain protein
AAKFIGLK_01132 1.9e-152 gst O Glutathione S-transferase
AAKFIGLK_01133 1.1e-181 add 3.5.4.4 F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AAKFIGLK_01134 1.9e-109 tdk 2.7.1.21 F thymidine kinase
AAKFIGLK_01135 3.6e-191 prfA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AAKFIGLK_01136 2e-141 prmB 2.1.1.297, 2.1.1.298 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
AAKFIGLK_01137 1.8e-102 ywlC 2.7.7.87, 3.1.3.48 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
AAKFIGLK_01138 2.7e-230 glyA 2.1.2.1 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AAKFIGLK_01139 6e-177 ndpA S 37-kD nucleoid-associated bacterial protein
AAKFIGLK_01140 1.4e-99 pvaA M lytic transglycosylase activity
AAKFIGLK_01141 3.8e-291 yfiB1 V abc transporter atp-binding protein
AAKFIGLK_01142 0.0 XK27_10035 V abc transporter atp-binding protein
AAKFIGLK_01143 1.4e-297 dltA 6.1.1.13 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
AAKFIGLK_01144 4.7e-235 dltB M Membrane protein involved in D-alanine export
AAKFIGLK_01145 2.2e-35 dltC 6.1.1.13 IQ Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
AAKFIGLK_01146 1.2e-238 dltD M Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AAKFIGLK_01147 0.0 3.6.3.8 P cation transport ATPase
AAKFIGLK_01148 1.2e-310 pabB 2.6.1.85, 4.1.3.27, 4.1.3.38 EH component I
AAKFIGLK_01150 0.0 metE 2.1.1.14 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AAKFIGLK_01151 2.6e-163 metF 1.5.1.20 E reductase
AAKFIGLK_01152 0.0 pgm 5.4.2.2, 5.4.2.8 G Phosphoglucomutase
AAKFIGLK_01153 2.1e-92 panT S ECF transporter, substrate-specific component
AAKFIGLK_01154 3.1e-90 coaBC 4.1.1.36, 6.3.2.5 H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AAKFIGLK_01155 7.1e-116 coaB 4.1.1.36, 6.3.2.5 H Phosphopantothenate-cysteine ligase
AAKFIGLK_01156 0.0 fhs 6.3.4.3 F Belongs to the formate--tetrahydrofolate ligase family
AAKFIGLK_01157 2.1e-120 T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
AAKFIGLK_01158 3.1e-230 T PhoQ Sensor
AAKFIGLK_01159 2.3e-29 rpsT J Binds directly to 16S ribosomal RNA
AAKFIGLK_01160 2.6e-169 coaA 2.7.1.33 F Pantothenic acid kinase
AAKFIGLK_01161 3.5e-103 rsmC 2.1.1.172 J Methyltransferase small domain protein
AAKFIGLK_01162 3e-224 pdp 2.4.2.2, 2.4.2.4 F Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate
AAKFIGLK_01163 1.8e-111 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AAKFIGLK_01164 3.7e-64 cdd 2.4.2.2, 3.5.4.5 F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
AAKFIGLK_01165 6.8e-190 tcsA S membrane
AAKFIGLK_01166 2.7e-280 xylG 3.6.3.17 S ABC transporter, ATP-binding protein
AAKFIGLK_01167 2.3e-177 yufP S Belongs to the binding-protein-dependent transport system permease family
AAKFIGLK_01168 1e-168 yufQ S Belongs to the binding-protein-dependent transport system permease family
AAKFIGLK_01169 3e-113 ycbL 3.1.2.6 S COG0491 Zn-dependent hydrolases, including glyoxylases
AAKFIGLK_01170 0.0 dinG 2.7.7.7, 3.6.4.12 L helicase involved in DNA repair and perhaps also replication
AAKFIGLK_01171 3e-76 ypmB S Protein conserved in bacteria
AAKFIGLK_01172 2.8e-213 aspB 2.6.1.1, 2.6.1.14 E Aminotransferase
AAKFIGLK_01173 9.3e-261 asnS 6.1.1.22 J Catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
AAKFIGLK_01174 4.8e-19
AAKFIGLK_01175 3e-63 tdcF 3.5.99.10 J endoribonuclease L-PSP
AAKFIGLK_01176 1.2e-123 queC 6.3.4.20 F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AAKFIGLK_01177 8.8e-83 queD 4.1.2.50, 4.2.3.12 H synthase
AAKFIGLK_01178 1.2e-134 queE 1.97.1.4, 4.3.99.3 H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
AAKFIGLK_01179 1.4e-94 queF 1.7.1.13 S Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily
AAKFIGLK_01180 5.8e-201 D nuclear chromosome segregation
AAKFIGLK_01181 3.8e-134 yejC S cyclic nucleotide-binding protein
AAKFIGLK_01182 5.5e-161 rapZ S Displays ATPase and GTPase activities
AAKFIGLK_01183 1.8e-181 ybhK S Required for morphogenesis under gluconeogenic growth conditions
AAKFIGLK_01184 2.2e-160 whiA K May be required for sporulation
AAKFIGLK_01185 2.2e-273 pepD E Dipeptidase
AAKFIGLK_01186 1.8e-145 XK27_10720 D peptidase activity
AAKFIGLK_01187 4.4e-291 adcA P Belongs to the bacterial solute-binding protein 9 family
AAKFIGLK_01188 2.6e-09
AAKFIGLK_01190 6.2e-169 yeiH S Membrane
AAKFIGLK_01191 1e-125 mur1 3.4.17.14, 3.5.1.28 NU muramidase
AAKFIGLK_01192 2.9e-165 cpsY K Transcriptional regulator
AAKFIGLK_01193 0.0 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
AAKFIGLK_01194 6.6e-59 phnA P Alkylphosphonate utilization operon protein PhnA
AAKFIGLK_01195 3.1e-105 artQ P ABC transporter (Permease
AAKFIGLK_01196 4.4e-112 glnQ 3.6.3.21 E abc transporter atp-binding protein
AAKFIGLK_01197 1.3e-156 aatB ET ABC transporter substrate-binding protein
AAKFIGLK_01198 1.1e-267 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AAKFIGLK_01199 6.8e-52
AAKFIGLK_01200 1e-44
AAKFIGLK_01201 9.4e-189 adhP 1.1.1.1 C alcohol dehydrogenase
AAKFIGLK_01202 8.8e-99 rimL J COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
AAKFIGLK_01203 8.7e-303 guaA 2.3.1.128, 6.3.5.2 F Catalyzes the synthesis of GMP from XMP
AAKFIGLK_01204 2.7e-126 gntR1 K transcriptional
AAKFIGLK_01205 4.9e-54 ylxM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AAKFIGLK_01206 3.8e-274 ffh 3.6.5.4 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AAKFIGLK_01207 2.7e-86
AAKFIGLK_01208 6e-91 niaR S small molecule binding protein (contains 3H domain)
AAKFIGLK_01209 5.3e-127 K DNA-binding helix-turn-helix protein
AAKFIGLK_01210 9.4e-158 ylqF S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AAKFIGLK_01211 1.3e-134 rnhB 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AAKFIGLK_01212 1e-165 GK ROK family
AAKFIGLK_01213 2.3e-156 dprA LU DNA protecting protein DprA
AAKFIGLK_01214 0.0 topA 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AAKFIGLK_01215 1.7e-82 mutF V AAA domain, putative AbiEii toxin, Type IV TA system
AAKFIGLK_01216 2.6e-52 V ABC-2 family transporter protein
AAKFIGLK_01218 6.1e-146 S TraX protein
AAKFIGLK_01219 5.1e-119 KT Transcriptional regulatory protein, C terminal
AAKFIGLK_01220 3.2e-221 T PhoQ Sensor
AAKFIGLK_01221 2.1e-257 trmFO 2.1.1.74 J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AAKFIGLK_01222 1.5e-222 XK27_05470 E Methionine synthase
AAKFIGLK_01223 7.2e-71 ndk 2.7.4.6 F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
AAKFIGLK_01224 4.5e-43 pspE P Rhodanese-like protein
AAKFIGLK_01225 1.8e-136 IQ Acetoin reductase
AAKFIGLK_01227 0.0 lepA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
AAKFIGLK_01230 0.0 alsS 2.2.1.6 EH Belongs to the TPP enzyme family
AAKFIGLK_01231 8.8e-133 budA 4.1.1.5 H Belongs to the alpha-acetolactate decarboxylase family
AAKFIGLK_01232 2.6e-39 C Pyridoxamine 5'-phosphate oxidase
AAKFIGLK_01233 2.4e-94 K COG COG0846 NAD-dependent protein deacetylases, SIR2 family
AAKFIGLK_01234 8.8e-78 S Macro domain
AAKFIGLK_01235 8.9e-67 mgrA K Transcriptional regulator, MarR family
AAKFIGLK_01236 2.2e-135 1.6.5.2 GM NmrA-like family
AAKFIGLK_01237 8.6e-168 C alcohol dehydrogenase
AAKFIGLK_01238 7e-130 proV E abc transporter atp-binding protein
AAKFIGLK_01239 3.8e-263 proWX P ABC transporter
AAKFIGLK_01240 2e-109 magIII L Base excision DNA repair protein, HhH-GPD family
AAKFIGLK_01241 3.7e-35 L Integrase core domain protein
AAKFIGLK_01242 0.0 V ABC transporter (Permease
AAKFIGLK_01243 7.3e-124 V abc transporter atp-binding protein
AAKFIGLK_01244 5.7e-92 tetR K transcriptional regulator
AAKFIGLK_01245 1.5e-138 S Phenazine biosynthesis protein
AAKFIGLK_01246 4.8e-92 2.7.7.65 T Psort location CytoplasmicMembrane, score
AAKFIGLK_01247 1.7e-132 cbiQ P cobalt transport
AAKFIGLK_01248 5.9e-157 P ABC transporter
AAKFIGLK_01249 1.1e-147 cbiO2 P ABC transporter, ATP-binding protein
AAKFIGLK_01250 2.7e-61 pnuC H nicotinamide mononucleotide transporter
AAKFIGLK_01251 4e-64 K Transcriptional regulator
AAKFIGLK_01252 3.9e-179 1.1.1.1 C nadph quinone reductase
AAKFIGLK_01253 1.6e-154 I Alpha/beta hydrolase family
AAKFIGLK_01254 2.1e-152 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
AAKFIGLK_01255 1.7e-38
AAKFIGLK_01256 1.6e-58 S Protein of unknown function with HXXEE motif
AAKFIGLK_01257 1e-99 K Transcriptional regulator, TetR family
AAKFIGLK_01258 5.2e-151 czcD P cation diffusion facilitator family transporter
AAKFIGLK_01259 1.8e-193 hemH 4.99.1.1, 4.99.1.9 H Catalyzes the ferrous insertion into protoporphyrin IX
AAKFIGLK_01260 2.8e-188 adhB 1.1.1.1, 1.1.1.14 E Dehydrogenase
AAKFIGLK_01261 2.4e-63 copY K Copper transport repressor, CopY TcrY family
AAKFIGLK_01262 3.1e-65 silP 1.9.3.1, 3.6.3.54 S cog cog4633
AAKFIGLK_01263 0.0 copA 3.6.3.54 P P-type ATPase
AAKFIGLK_01264 2.5e-122 spxB 1.2.3.3, 1.2.5.1 EH Belongs to the TPP enzyme family
AAKFIGLK_01265 3.5e-144 G protein with an alpha beta hydrolase fold
AAKFIGLK_01266 2e-124 ybhF_2 V abc transporter atp-binding protein
AAKFIGLK_01267 1.8e-177 ybhR V ABC transporter
AAKFIGLK_01268 6.5e-108 K Bacterial regulatory proteins, tetR family
AAKFIGLK_01269 7.9e-140 2.4.2.3 F Phosphorylase superfamily
AAKFIGLK_01270 6e-109 gph 3.1.3.18 S HAD hydrolase, family IA, variant 1
AAKFIGLK_01271 0.0 V Type III restriction enzyme, res subunit
AAKFIGLK_01272 6e-177 yclQ P ABC-type enterochelin transport system, periplasmic component
AAKFIGLK_01273 1.1e-229 dinF V Mate efflux family protein
AAKFIGLK_01274 2.4e-260 S Psort location CytoplasmicMembrane, score
AAKFIGLK_01275 9.5e-308 FbpA K RNA-binding protein homologous to eukaryotic snRNP
AAKFIGLK_01277 2.3e-134 S TraX protein
AAKFIGLK_01278 6.1e-94 thiJ 2.7.11.1, 3.5.1.124 S DJ-1 family
AAKFIGLK_01279 1.1e-144 pyrK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )
AAKFIGLK_01280 1.1e-175 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
AAKFIGLK_01281 1.3e-125 pyrF 4.1.1.23 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
AAKFIGLK_01282 6.3e-111 pyrE 2.4.2.10, 4.1.1.23 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AAKFIGLK_01283 3.2e-235 nylA 3.5.1.4 J Belongs to the amidase family
AAKFIGLK_01284 1.1e-147 yckB ET Belongs to the bacterial solute-binding protein 3 family
AAKFIGLK_01285 7.1e-81 yecS P ABC transporter (Permease
AAKFIGLK_01286 0.0 sasH 3.1.3.5, 3.6.1.45 F Belongs to the 5'-nucleotidase family
AAKFIGLK_01287 7.1e-170 bglC K Transcriptional regulator
AAKFIGLK_01288 2.8e-244 mnmE S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AAKFIGLK_01289 1.1e-237 agcS E (Alanine) symporter
AAKFIGLK_01290 0.0 pcrA 3.6.4.12 L ATP-dependent DNA helicase
AAKFIGLK_01291 2.9e-227 metY 2.5.1.49 E o-acetylhomoserine
AAKFIGLK_01292 2.6e-135 S haloacid dehalogenase-like hydrolase
AAKFIGLK_01293 4.2e-86 tpx 1.11.1.15 O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AAKFIGLK_01294 2.1e-111 hsdS2 2.1.1.72 V Type I restriction modification DNA specificity domain
AAKFIGLK_01295 4.7e-35 M1-755 P Hemerythrin HHE cation binding domain protein
AAKFIGLK_01296 1.6e-233 XK27_04775 S hemerythrin HHE cation binding domain
AAKFIGLK_01297 5.5e-153 truB 5.4.99.25 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AAKFIGLK_01298 8.7e-170 ribF 2.7.1.26, 2.7.7.2 H Belongs to the ribF family
AAKFIGLK_01299 2.1e-70 spxA 1.20.4.1 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
AAKFIGLK_01300 1e-44 yktA S Belongs to the UPF0223 family
AAKFIGLK_01301 3.2e-141 suhB 3.1.3.25 G Belongs to the inositol monophosphatase superfamily
AAKFIGLK_01302 1.5e-244 rsmF 2.1.1.176, 2.1.1.178 J NOL1 NOP2 sun family protein
AAKFIGLK_01303 4.5e-155 pstS P phosphate
AAKFIGLK_01304 1.4e-156 pstC P probably responsible for the translocation of the substrate across the membrane
AAKFIGLK_01305 4.5e-155 pstA P phosphate transport system permease
AAKFIGLK_01306 3.4e-149 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
AAKFIGLK_01307 3.9e-139 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
AAKFIGLK_01308 3.2e-113 phoU P Plays a role in the regulation of phosphate uptake
AAKFIGLK_01309 0.0 pepN 3.4.11.2 E aminopeptidase
AAKFIGLK_01310 2.5e-192 xerS D Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division
AAKFIGLK_01311 1.8e-184 lplA 6.3.1.20 H Lipoate-protein ligase
AAKFIGLK_01312 2.6e-38
AAKFIGLK_01313 0.0 glgP 2.4.1.1 GT35 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
AAKFIGLK_01314 7.3e-299 malQ 2.4.1.25 GH77 G 4-alpha-glucanotransferase
AAKFIGLK_01315 1.6e-172 malR K Transcriptional regulator
AAKFIGLK_01316 2.1e-227 malX G ABC transporter
AAKFIGLK_01317 9.7e-250 malF P ABC transporter (Permease
AAKFIGLK_01318 2.2e-151 malG P ABC transporter (Permease
AAKFIGLK_01319 1.8e-212 msmX P Belongs to the ABC transporter superfamily
AAKFIGLK_01320 1.9e-23 tatA U protein secretion
AAKFIGLK_01321 1.3e-120 tatC U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AAKFIGLK_01322 5.3e-290 ywbL P COG0672 High-affinity Fe2 Pb2 permease
AAKFIGLK_01323 5.8e-230 ycdB P peroxidase
AAKFIGLK_01324 2.2e-146 ycdO P periplasmic lipoprotein involved in iron transport
AAKFIGLK_01325 0.0 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
AAKFIGLK_01326 0.0 3.5.1.28 M N-Acetylmuramoyl-L-alanine amidase
AAKFIGLK_01327 0.0 3.5.1.28 NU amidase activity
AAKFIGLK_01328 0.0 lpdA 1.8.1.4 C Dehydrogenase
AAKFIGLK_01329 1.1e-211 acoC 2.3.1.12 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
AAKFIGLK_01330 6.4e-182 acoB 1.2.4.1, 1.2.4.4 C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
AAKFIGLK_01331 1.5e-183 acoA 1.2.4.1, 1.2.4.4 C Dehydrogenase E1 component
AAKFIGLK_01332 2.1e-198 hpk9 2.7.13.3 T protein histidine kinase activity
AAKFIGLK_01333 9.3e-226 2.7.13.3 T protein histidine kinase activity
AAKFIGLK_01334 2.3e-300 S the current gene model (or a revised gene model) may contain a frame shift
AAKFIGLK_01335 3.5e-233 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
AAKFIGLK_01336 5.9e-120 ung 3.2.2.27 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AAKFIGLK_01337 2.1e-211 yeaB K Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AAKFIGLK_01338 5.8e-247 dacA1 3.4.16.4 M Belongs to the peptidase S11 family
AAKFIGLK_01339 2e-152 rssA S Phospholipase, patatin family
AAKFIGLK_01340 5e-100 estA E Lysophospholipase L1 and related esterases
AAKFIGLK_01341 2e-278 S unusual protein kinase
AAKFIGLK_01342 4.1e-38 S granule-associated protein
AAKFIGLK_01343 2e-285 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
AAKFIGLK_01344 6.8e-196 S hmm pf01594
AAKFIGLK_01345 9e-107 G Belongs to the phosphoglycerate mutase family
AAKFIGLK_01346 2.8e-108 G Belongs to the phosphoglycerate mutase family
AAKFIGLK_01347 1.1e-107 pgm G Belongs to the phosphoglycerate mutase family
AAKFIGLK_01348 3.3e-136 supH 3.1.3.102, 3.1.3.104 S Sucrose-6F-phosphate phosphohydrolase
AAKFIGLK_01350 6.1e-191 wbbI M transferase activity, transferring glycosyl groups
AAKFIGLK_01351 1.5e-186 sacB GT2,GT4 M Stealth protein CR2, conserved region 2
AAKFIGLK_01352 1.7e-215 glf 5.4.99.9 M UDP-galactopyranose mutase
AAKFIGLK_01353 9.8e-245 epsU S Polysaccharide biosynthesis protein
AAKFIGLK_01354 8e-176
AAKFIGLK_01355 1.4e-157 M Glycosyltransferase like family 2
AAKFIGLK_01356 2.3e-168 M Glycosyltransferase, group 2 family protein
AAKFIGLK_01357 7.6e-164
AAKFIGLK_01358 1.5e-120 Z012_10770 M Domain of unknown function (DUF1919)
AAKFIGLK_01359 8.9e-212 wcoF M Glycosyltransferase, group 1 family protein
AAKFIGLK_01360 1.5e-219 rgpAc GT4 M group 1 family protein
AAKFIGLK_01361 2.7e-252 cpsE M Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
AAKFIGLK_01362 7.7e-116 cpsD D COG0489 ATPases involved in chromosome partitioning
AAKFIGLK_01363 1.2e-110 cps4C M biosynthesis protein
AAKFIGLK_01364 6.8e-133 cpsB 3.1.3.48 GM Capsular polysaccharide biosynthesis protein
AAKFIGLK_01365 1.9e-251 cps4A K Cell envelope-like function transcriptional attenuator common domain protein
AAKFIGLK_01366 4.9e-128 deoD 2.4.2.1, 2.4.2.28 F purine nucleoside phosphorylase
AAKFIGLK_01367 9e-130 yfeJ 6.3.5.2 F glutamine amidotransferase
AAKFIGLK_01368 4.1e-162 clcA_2 P chloride
AAKFIGLK_01369 2.2e-51 S LemA family
AAKFIGLK_01370 8.3e-148 punA 2.4.2.1 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AAKFIGLK_01371 2.8e-86 S Protein of unknown function (DUF1697)
AAKFIGLK_01372 1.4e-231 deoB 5.4.2.7 G Phosphotransfer between the C1 and C5 carbon atoms of pentose
AAKFIGLK_01373 4.7e-120 rpiA 2.7.1.12, 2.7.1.15, 5.3.1.6 G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AAKFIGLK_01374 7.4e-253 V Glucan-binding protein C
AAKFIGLK_01375 8.5e-227 V Glucan-binding protein C
AAKFIGLK_01376 1.4e-107 ung2 3.2.2.27 L Uracil-DNA glycosylase
AAKFIGLK_01377 5e-273 pepV 3.5.1.18 E Dipeptidase
AAKFIGLK_01378 4.9e-27 dmpI 5.3.2.6 G Belongs to the 4-oxalocrotonate tautomerase family
AAKFIGLK_01379 1.4e-221 L the current gene model (or a revised gene model) may contain a frame shift
AAKFIGLK_01380 1.9e-89 yybC
AAKFIGLK_01381 1.1e-75 XK27_03610 K Gnat family
AAKFIGLK_01382 1.5e-56 rplT J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AAKFIGLK_01383 8.1e-28 rpmI J Belongs to the bacterial ribosomal protein bL35 family
AAKFIGLK_01384 1e-85 infC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AAKFIGLK_01385 3.1e-119 cmk 1.17.7.4, 2.5.1.19, 2.7.1.26, 2.7.4.25, 2.7.7.2, 6.3.2.1 F Belongs to the cytidylate kinase family. Type 1 subfamily
AAKFIGLK_01386 9.4e-17 M LysM domain
AAKFIGLK_01387 1.2e-85 ebsA S Family of unknown function (DUF5322)
AAKFIGLK_01388 2.2e-229 pepT 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
AAKFIGLK_01389 0.0 lytC 3.4.17.14, 3.5.1.28 M N-acetylmuramoyl-L-alanine amidase
AAKFIGLK_01390 3.3e-95 lepB 3.4.21.89 U Belongs to the peptidase S26 family
AAKFIGLK_01391 9.5e-220 G COG0457 FOG TPR repeat
AAKFIGLK_01392 4e-175 yubA S permease
AAKFIGLK_01393 4.3e-91 mutX 3.6.1.55 F NTP pyrophosphohydrolases including oxidative damage repair enzymes
AAKFIGLK_01394 7.3e-164 ftsX D Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation
AAKFIGLK_01395 3.2e-124 ftsE D cell division ATP-binding protein FtsE
AAKFIGLK_01396 5.7e-183 prfB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AAKFIGLK_01397 1e-204 queG 1.17.99.6 C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AAKFIGLK_01398 2.1e-154 yjjH S Calcineurin-like phosphoesterase
AAKFIGLK_01399 8.5e-131 nfrA 1.5.1.38, 1.5.1.39 C nitroreductase
AAKFIGLK_01400 0.0 pacL 3.6.3.8 P cation transport ATPase
AAKFIGLK_01401 5.3e-68 ywiB S Domain of unknown function (DUF1934)
AAKFIGLK_01402 9.1e-145 XK27_00115 2.3.1.128 K Acetyltransferase GNAT family
AAKFIGLK_01403 2e-146 yidA S hydrolases of the HAD superfamily
AAKFIGLK_01404 1.8e-226 murM 2.3.2.10, 2.3.2.16 V protein involved in methicillin resistance
AAKFIGLK_01405 3.3e-56 S Protein of unknown function (DUF454)
AAKFIGLK_01406 2.1e-154 vicX 3.1.26.11 S Metal-dependent hydrolases of the beta-lactamase superfamily I
AAKFIGLK_01407 1e-235 vicK 2.7.13.3 T Histidine kinase
AAKFIGLK_01408 3.8e-128 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
AAKFIGLK_01409 1.6e-140 glnQ 3.6.3.21 E abc transporter atp-binding protein
AAKFIGLK_01410 7.4e-12
AAKFIGLK_01412 7.6e-94 repA S Replication initiator protein A (RepA) N-terminus
AAKFIGLK_01414 8.1e-28 XK27_05745
AAKFIGLK_01415 1.2e-216 mutY L A G-specific adenine glycosylase
AAKFIGLK_01417 3.8e-09
AAKFIGLK_01418 1.7e-37
AAKFIGLK_01420 0.0 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AAKFIGLK_01421 0.0 mutS2 L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
AAKFIGLK_01422 4.1e-90 cvpA S toxin biosynthetic process
AAKFIGLK_01423 1.2e-14 zapA D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AAKFIGLK_01424 3.7e-154 rnhC 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AAKFIGLK_01425 7.4e-115 lepB 3.4.21.89 U Belongs to the peptidase S26 family
AAKFIGLK_01426 0.0 recD2 3.1.11.5 L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
AAKFIGLK_01427 1.3e-46 azlD S branched-chain amino acid
AAKFIGLK_01428 2.6e-113 azlC E AzlC protein
AAKFIGLK_01429 6.2e-185 tsaD 2.3.1.234 O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AAKFIGLK_01430 1.5e-71 rimI 2.3.1.128 K This enzyme acetylates the N-terminal alanine of ribosomal protein S18
AAKFIGLK_01431 1.5e-118 yeaZ 2.3.1.234 O COG1214, inactive homolog of metal-dependent proteases
AAKFIGLK_01432 3.3e-33 ykzG S Belongs to the UPF0356 family
AAKFIGLK_01433 0.0 rnjA S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AAKFIGLK_01434 1.5e-115 pscB M CHAP domain protein
AAKFIGLK_01435 5.2e-264 glnA 6.3.1.2 E glutamine synthetase
AAKFIGLK_01436 8.5e-63 glnR K Transcriptional regulator
AAKFIGLK_01437 2.5e-86 S Fusaric acid resistance protein-like
AAKFIGLK_01438 9.9e-222 pgk 2.7.2.3, 5.3.1.1 F Belongs to the phosphoglycerate kinase family
AAKFIGLK_01439 1.3e-103
AAKFIGLK_01440 7.1e-181 gap 1.2.1.12 C Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
AAKFIGLK_01441 0.0 fusA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AAKFIGLK_01442 3.9e-81 rpsG J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
AAKFIGLK_01443 2.3e-69 rpsL J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AAKFIGLK_01444 6.9e-142 purR 2.4.2.7 F operon repressor
AAKFIGLK_01445 2.6e-177 cbf S 3'-5' exoribonuclease yhaM
AAKFIGLK_01446 7.9e-169 rmuC S RmuC domain protein
AAKFIGLK_01447 5e-116 thiN 2.7.6.2 H thiamine pyrophosphokinase
AAKFIGLK_01448 7.8e-120 rpe 5.1.3.1 G Belongs to the ribulose-phosphate 3-epimerase family
AAKFIGLK_01449 1.5e-158 rsgA 3.1.3.100 G One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
AAKFIGLK_01451 1.7e-154 ksgA 2.1.1.182 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
AAKFIGLK_01452 3.2e-98 rnmV 3.1.26.8 J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AAKFIGLK_01453 1.9e-141 tatD L Hydrolase, tatd
AAKFIGLK_01454 5.2e-188 L Belongs to the 'phage' integrase family
AAKFIGLK_01455 6e-21
AAKFIGLK_01456 9.3e-129
AAKFIGLK_01458 1e-44
AAKFIGLK_01461 1.4e-16
AAKFIGLK_01464 1.5e-18 K Helix-turn-helix
AAKFIGLK_01465 1.7e-70 yccU S CoA-binding protein
AAKFIGLK_01466 5.3e-50 trxA O Belongs to the thioredoxin family
AAKFIGLK_01467 5.6e-141 S Macro domain protein
AAKFIGLK_01468 6.3e-59 L thioesterase
AAKFIGLK_01469 1.6e-49 bta 1.8.1.8 CO cell redox homeostasis
AAKFIGLK_01471 2.5e-273 opuD M Belongs to the BCCT transporter (TC 2.A.15) family
AAKFIGLK_01472 4.5e-103 abiGI K Transcriptional regulator, AbiEi antitoxin
AAKFIGLK_01473 9.5e-31 XK27_00530 M CHAP domain protein
AAKFIGLK_01474 4.8e-13 L Helix-hairpin-helix DNA-binding motif class 1
AAKFIGLK_01475 2.2e-30 S Domain of unknown function (DUF1912)
AAKFIGLK_01476 1e-168 mmuM 1.5.1.20, 2.1.1.10 H Homocysteine
AAKFIGLK_01477 4.1e-248 mmuP E amino acid
AAKFIGLK_01478 3.9e-110 engB D Necessary for normal cell division and for the maintenance of normal septation
AAKFIGLK_01479 2.6e-225 clpX O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AAKFIGLK_01480 9.7e-22
AAKFIGLK_01481 1.2e-88 folA 1.5.1.3, 1.5.1.47, 2.1.1.45, 3.5.4.12 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AAKFIGLK_01482 2.7e-165 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AAKFIGLK_01483 1.6e-208 mvaS 2.3.3.10 I synthase
AAKFIGLK_01484 4.5e-225 mvaA 1.1.1.34, 1.1.1.88, 2.3.1.9 C Belongs to the HMG-CoA reductase family
AAKFIGLK_01485 3e-78 K hmm pf08876
AAKFIGLK_01486 1.2e-118 yqfA K protein, Hemolysin III
AAKFIGLK_01487 4.1e-29 pspC KT PspC domain protein
AAKFIGLK_01488 4.2e-192 S Protein of unknown function (DUF3114)
AAKFIGLK_01489 2.1e-158 S hydrolases or acyltransferases (alpha beta hydrolase superfamily)
AAKFIGLK_01490 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AAKFIGLK_01492 5.7e-247 mgs 2.4.1.337 GT4 M Glycosyltransferase, group 1 family protein
AAKFIGLK_01493 5.2e-192 dgs 2.4.1.208 GT4 M Glycosyltransferase, group 1 family protein
AAKFIGLK_01494 0.0 U protein secretion
AAKFIGLK_01495 3.8e-117 mtnN 3.2.2.9 E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AAKFIGLK_01496 4.6e-23
AAKFIGLK_01497 5.9e-97 nudF 3.6.1.13 L AdP-ribose pyrophosphatase
AAKFIGLK_01498 3.3e-245 glmU 2.3.1.157, 2.7.7.23 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AAKFIGLK_01499 0.0 mgtA 3.6.3.2 P COG0474 Cation transport ATPase
AAKFIGLK_01500 8.7e-48 S ABC-2 family transporter protein
AAKFIGLK_01501 1.9e-147 V ABC transporter, ATP-binding protein
AAKFIGLK_01502 1.5e-186 fni 1.1.1.88, 5.3.3.2 C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
AAKFIGLK_01503 2.4e-165 mvaK2 2.7.1.36, 2.7.1.43, 2.7.4.2 I phosphomevalonate kinase
AAKFIGLK_01504 4.5e-169 mvaD 4.1.1.33 I diphosphomevalonate decarboxylase
AAKFIGLK_01505 1.4e-135 mvk 1.1.1.88, 2.3.3.10, 2.7.1.36 I mevalonate kinase
AAKFIGLK_01506 6.7e-248 merA 1.16.1.1 C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AAKFIGLK_01507 3e-179 ybdK T ATPase histidine kinase DNA gyrase B HSP90 domain protein
AAKFIGLK_01508 1.3e-109 T Response regulator receiver domain protein
AAKFIGLK_01509 5.5e-50 T peptidase
AAKFIGLK_01510 5.6e-120 E alpha/beta hydrolase fold
AAKFIGLK_01512 6.6e-196 ald 1.4.1.1 C Belongs to the AlaDH PNT family
AAKFIGLK_01513 6.5e-215 hipO 3.5.1.47 E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
AAKFIGLK_01514 2.7e-126 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
AAKFIGLK_01515 3.9e-114 S VIT family
AAKFIGLK_01516 9.2e-25
AAKFIGLK_01517 1e-27 XK27_00085 K Transcriptional
AAKFIGLK_01518 9e-197 yceA S Belongs to the UPF0176 family
AAKFIGLK_01519 4.7e-123 nagB 3.1.1.31, 3.5.99.6 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
AAKFIGLK_01520 2.1e-199 queA 2.4.99.17 J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AAKFIGLK_01521 0.0 lmrA V abc transporter atp-binding protein
AAKFIGLK_01522 0.0 mdlB V abc transporter atp-binding protein
AAKFIGLK_01528 4.4e-120 mreC M Involved in formation and maintenance of cell shape
AAKFIGLK_01529 5.1e-82 mreD M rod shape-determining protein MreD
AAKFIGLK_01530 1.9e-84 usp 3.5.1.28 CBM50 S CHAP domain
AAKFIGLK_01531 9.5e-175 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AAKFIGLK_01532 1.8e-215 araT 2.6.1.1 E Aminotransferase
AAKFIGLK_01533 3.7e-137 recO L Involved in DNA repair and RecF pathway recombination
AAKFIGLK_01534 3.5e-183 plsX 2.3.1.15 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
AAKFIGLK_01535 1.4e-29 acpP1 IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
AAKFIGLK_01536 3.4e-129 purC 4.1.1.21, 4.3.2.2, 6.3.2.6 F Belongs to the SAICAR synthetase family
AAKFIGLK_01537 0.0 purL 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AAKFIGLK_01538 3e-273 purF 2.4.2.14 F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AAKFIGLK_01539 7.9e-188 purM 6.3.3.1, 6.3.4.13 F Phosphoribosylformylglycinamidine cyclo-ligase
AAKFIGLK_01540 5.4e-98 purN 2.1.2.2 F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AAKFIGLK_01541 3.4e-291 purH 2.1.2.3, 3.5.4.10 F Bifunctional purine biosynthesis protein PurH
AAKFIGLK_01542 6.1e-219 L Transposase
AAKFIGLK_01543 1.2e-12 L Transposase
AAKFIGLK_01544 5e-232 S AAA ATPase domain
AAKFIGLK_01545 8.9e-124 dam2 2.1.1.72 L DNA methyltransferase
AAKFIGLK_01546 1.7e-156 S CHAP domain
AAKFIGLK_01547 6.1e-238 purD 6.3.4.13 F Belongs to the GARS family
AAKFIGLK_01548 5.9e-80 purE 5.4.99.18 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AAKFIGLK_01549 3.7e-199 purK 6.3.4.18 F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AAKFIGLK_01550 4.4e-49 1.1.1.169 H Ketopantoate reductase
AAKFIGLK_01551 4.7e-32
AAKFIGLK_01552 1.8e-84
AAKFIGLK_01553 1.6e-246 purB 4.3.2.2 F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AAKFIGLK_01555 0.0 argS 6.1.1.19 J Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
AAKFIGLK_01556 3.4e-68 argR K Regulates arginine biosynthesis genes
AAKFIGLK_01557 5.3e-54 ymcA 3.6.3.21 S Belongs to the UPF0342 family
AAKFIGLK_01558 0.0 mutS L that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AAKFIGLK_01559 1.5e-77 S Protein of unknown function (DUF3021)
AAKFIGLK_01560 1.1e-69 K LytTr DNA-binding domain
AAKFIGLK_01562 0.0 mutL L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AAKFIGLK_01564 7.8e-103 ruvA 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
AAKFIGLK_01565 7.3e-103 tag 3.2.2.20 L 3-methyladenine DNA glycosylase
AAKFIGLK_01566 1.2e-225 cinA 3.5.1.42 S Belongs to the CinA family
AAKFIGLK_01567 1.2e-203 recA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AAKFIGLK_01568 3.9e-66 spxA_2 1.20.4.1 P Belongs to the ArsC family
AAKFIGLK_01569 0.0 sraP UW Hep Hag repeat protein
AAKFIGLK_01570 5.4e-189 nss M transferase activity, transferring glycosyl groups
AAKFIGLK_01571 3.6e-16 S Accessory secretory protein Sec, Asp5
AAKFIGLK_01572 2.6e-17 S Accessory secretory protein Sec Asp4
AAKFIGLK_01573 1.7e-241 gtf2 M A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1
AAKFIGLK_01574 5.9e-280 gtf1 2.4.1.52 GT4 M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
AAKFIGLK_01575 0.0 secA2 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
AAKFIGLK_01576 3.2e-77 asp3 S Accessory Sec system protein Asp3
AAKFIGLK_01577 3.2e-289 asp2 3.4.11.5 S Accessory Sec system protein Asp2
AAKFIGLK_01578 5.5e-289 asp1 S Accessory Sec system protein Asp1
AAKFIGLK_01579 8e-211 secY2 U Part of the accessory SecA2 SecY2 system specifically required for export of
AAKFIGLK_01580 0.0 M family 8
AAKFIGLK_01581 0.0 sbcC L ATPase involved in DNA repair
AAKFIGLK_01582 1.1e-217 sbcD L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
AAKFIGLK_01583 0.0 GM domain, Protein
AAKFIGLK_01584 0.0 zmpB M signal peptide protein, YSIRK family
AAKFIGLK_01585 8.9e-236 M domain protein
AAKFIGLK_01586 8.2e-120 liaI S membrane
AAKFIGLK_01587 1.3e-73 XK27_02470 K LytTr DNA-binding domain
AAKFIGLK_01588 1.5e-308 KT response to antibiotic
AAKFIGLK_01589 4.5e-118 yebC M Membrane
AAKFIGLK_01590 5.4e-256 XK27_03190 S hydrolases of the HAD superfamily
AAKFIGLK_01591 2.3e-176 ansA 3.5.1.1 EJ COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D
AAKFIGLK_01593 2.9e-31 yozG K Transcriptional regulator
AAKFIGLK_01597 0.0 recG 3.6.4.12 L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AAKFIGLK_01598 2.2e-191 alr 5.1.1.1, 5.1.1.5 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AAKFIGLK_01599 3.4e-61 acpS 2.7.6.3, 2.7.8.7, 5.1.1.1 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
AAKFIGLK_01600 1e-195 aroF 2.5.1.54 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AAKFIGLK_01601 5.5e-197 aroF 2.5.1.54 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AAKFIGLK_01602 0.0 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
AAKFIGLK_01604 1.9e-188 manA 5.3.1.8 G mannose-6-phosphate isomerase
AAKFIGLK_01605 7.2e-169 scrK 2.7.1.2, 2.7.1.4 GK Fructokinase
AAKFIGLK_01606 0.0 scrA 2.7.1.201, 2.7.1.208, 2.7.1.211 G pts system
AAKFIGLK_01607 2.7e-290 scrB 3.2.1.26, 3.2.1.80 GH32 G invertase
AAKFIGLK_01608 3.7e-179 scrR K Transcriptional regulator
AAKFIGLK_01609 1.3e-70 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AAKFIGLK_01610 1.7e-61 yqhY S protein conserved in bacteria
AAKFIGLK_01611 7.1e-98 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AAKFIGLK_01612 3.3e-85 comEB 3.5.4.12 F ComE operon protein 2
AAKFIGLK_01613 5.4e-187 pepP 3.4.11.9, 3.4.13.9 E Belongs to the peptidase M24B family
AAKFIGLK_01615 1.8e-145 V 'abc transporter, ATP-binding protein
AAKFIGLK_01622 0.0 uvrA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AAKFIGLK_01623 3.2e-167 corA P COG0598 Mg2 and Co2 transporters
AAKFIGLK_01624 5e-122 XK27_01040 S Protein of unknown function (DUF1129)
AAKFIGLK_01626 1.7e-35 rpsR J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AAKFIGLK_01627 1.5e-45 ssb L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
AAKFIGLK_01628 0.0 M Putative cell wall binding repeat
AAKFIGLK_01629 1.7e-223 M Putative cell wall binding repeat
AAKFIGLK_01631 0.0 mprF 2.3.2.3 S Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AAKFIGLK_01632 5.5e-173 mleP S Sodium Bile acid symporter family
AAKFIGLK_01633 1.6e-310 sfcA 1.1.1.38, 4.1.1.101 C malic enzyme
AAKFIGLK_01634 4.7e-47 K Helix-turn-helix
AAKFIGLK_01635 2e-118 mleR K malolactic fermentation system
AAKFIGLK_01636 1.8e-112 XK27_00785 S CAAX protease self-immunity
AAKFIGLK_01637 2.9e-233 EGP Major facilitator Superfamily
AAKFIGLK_01638 5.5e-63 rmaI K Transcriptional regulator, MarR family
AAKFIGLK_01639 9.7e-95 maa 2.3.1.79 GK Maltose O-acetyltransferase
AAKFIGLK_01640 1.2e-132 S N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity
AAKFIGLK_01641 0.0 3.5.1.28 M domain protein
AAKFIGLK_01642 0.0 2.4.1.5 GH13 M KxYKxGKxW signal domain protein
AAKFIGLK_01643 1.4e-24
AAKFIGLK_01647 1.3e-10 sraP UW domain, Protein
AAKFIGLK_01648 1.8e-279 opuD M Belongs to the BCCT transporter (TC 2.A.15) family
AAKFIGLK_01649 3.4e-36 P (belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AAKFIGLK_01650 2.4e-135 S double-stranded DNA endodeoxyribonuclease activity
AAKFIGLK_01651 1.2e-188 L Uncharacterized conserved protein (DUF2075)
AAKFIGLK_01652 1.2e-41 S Nucleotide pyrophosphohydrolase
AAKFIGLK_01653 3.8e-45 K Helix-turn-helix domain
AAKFIGLK_01654 4.4e-45 S Phage derived protein Gp49-like (DUF891)
AAKFIGLK_01655 8.4e-134 sdh 1.1.1.276, 1.1.1.313, 1.1.1.381 S Belongs to the short-chain dehydrogenases reductases (SDR) family
AAKFIGLK_01656 6.6e-199 MA20_36090 S Protein of unknown function (DUF2974)
AAKFIGLK_01657 6.1e-114 1.14.14.5 C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AAKFIGLK_01658 2e-152 5.2.1.8 G hydrolase
AAKFIGLK_01659 1.9e-25 P Hemerythrin HHE cation binding domain protein
AAKFIGLK_01660 1.8e-138 XK27_00880 3.5.1.28 M Glycosyl hydrolase, family 25
AAKFIGLK_01661 2.3e-81 ybaK S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AAKFIGLK_01662 3.3e-115 pgm6 5.4.2.11, 5.4.2.12 G Phosphoglycerate mutase
AAKFIGLK_01664 1.2e-174 S hydrolase
AAKFIGLK_01665 8.4e-23
AAKFIGLK_01666 6.3e-137 M LysM domain
AAKFIGLK_01667 1.4e-286 lysS 6.1.1.6 J Belongs to the class-II aminoacyl-tRNA synthetase family
AAKFIGLK_01668 2.5e-15
AAKFIGLK_01669 6.2e-180 dapB 1.4.1.12, 1.4.1.16, 1.4.1.26 S Dihydrodipicolinate reductase, N-terminus
AAKFIGLK_01670 5.3e-97 K MerR, DNA binding
AAKFIGLK_01671 0.0 L helicase
AAKFIGLK_01672 9.5e-65 nudG 3.6.1.55, 3.6.1.65 L Belongs to the Nudix hydrolase family
AAKFIGLK_01673 2.8e-11
AAKFIGLK_01674 4.3e-234 mntH P H( )-stimulated, divalent metal cation uptake system
AAKFIGLK_01675 1.1e-33 XK27_12190 S protein conserved in bacteria
AAKFIGLK_01677 1.1e-87 bioY S biotin synthase
AAKFIGLK_01678 1.7e-251 yegQ O Peptidase U32
AAKFIGLK_01679 1.5e-177 yegQ O Peptidase U32
AAKFIGLK_01681 0.0 M Putative cell wall binding repeat
AAKFIGLK_01682 1.7e-135 T Ser Thr phosphatase family protein
AAKFIGLK_01683 9.4e-34 S Immunity protein 41
AAKFIGLK_01684 0.0 pepO 3.4.24.71 O Peptidase family M13
AAKFIGLK_01685 2.6e-07 S Enterocin A Immunity
AAKFIGLK_01686 2.1e-196 S KAP family P-loop domain
AAKFIGLK_01687 0.0 2.4.1.5 GH13 M KxYKxGKxW signal domain protein
AAKFIGLK_01689 7.5e-259 S dextransucrase activity
AAKFIGLK_01690 0.0 2.4.1.5 GH13 M KxYKxGKxW signal domain protein
AAKFIGLK_01691 2.3e-13 M Putative cell wall binding repeat
AAKFIGLK_01692 4.8e-279 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AAKFIGLK_01693 6.3e-93 pat 2.3.1.183 M acetyltransferase
AAKFIGLK_01694 3.5e-291 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AAKFIGLK_01695 8.8e-124 alkD L DNA alkylation repair enzyme
AAKFIGLK_01696 2.8e-199 asd 1.2.1.11 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AAKFIGLK_01697 1.9e-172 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AAKFIGLK_01698 9.3e-124 rnc 3.1.26.3 J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
AAKFIGLK_01699 0.0 smc D Required for chromosome condensation and partitioning
AAKFIGLK_01700 5.9e-89 S Protein of unknown function (DUF3278)
AAKFIGLK_01701 2.4e-22 WQ51_00220 K Helix-turn-helix domain
AAKFIGLK_01702 3.9e-198 pheS 6.1.1.20 J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AAKFIGLK_01703 6.4e-93 paiA 2.3.1.57 K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
AAKFIGLK_01704 0.0 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
AAKFIGLK_01706 7e-56 nrdD_1 1.1.98.6, 1.17.4.1 F Ribonucleoside-triphosphate reductase
AAKFIGLK_01707 1.3e-240 XK27_08130 K Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
AAKFIGLK_01709 2.2e-82 S ECF-type riboflavin transporter, S component
AAKFIGLK_01710 1.9e-150 pdxK 2.7.1.35 H Belongs to the pyridoxine kinase family
AAKFIGLK_01711 1.6e-51 XK27_01265 S ECF-type riboflavin transporter, S component
AAKFIGLK_01712 1.9e-294 yfmM S abc transporter atp-binding protein
AAKFIGLK_01713 3.9e-254 noxE P NADH oxidase
AAKFIGLK_01714 0.0 S dextransucrase activity
AAKFIGLK_01715 3.2e-186 S abc transporter atp-binding protein
AAKFIGLK_01716 9e-142 S ABC-2 family transporter protein
AAKFIGLK_01717 2.5e-141 S ABC-2 family transporter protein
AAKFIGLK_01718 2.3e-24
AAKFIGLK_01719 5.4e-87
AAKFIGLK_01720 1.1e-47
AAKFIGLK_01721 5.1e-82 3.4.21.89 S RDD family
AAKFIGLK_01722 1.8e-159 yjlA EG membrane
AAKFIGLK_01723 0.0 fruA 3.2.1.1, 3.2.1.26, 3.2.1.65, 3.2.1.80 GH13,GH32 G Belongs to the glycosyl hydrolase 32 family
AAKFIGLK_01724 4.7e-224 2.7.1.194, 2.7.1.202, 2.7.1.204 H Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
AAKFIGLK_01725 3.7e-42 ulaB 2.7.1.194 G COG3414 Phosphotransferase system galactitol-specific IIB component
AAKFIGLK_01726 6.1e-220 ulaA 2.7.1.194 S PTS system sugar-specific permease component
AAKFIGLK_01727 4e-124 tktN 2.2.1.1 G Transketolase
AAKFIGLK_01728 5.6e-124 tktC 2.2.1.1 G Transketolase, pyrimidine binding domain
AAKFIGLK_01729 2e-147 sdaAA 4.3.1.17 E L-serine dehydratase
AAKFIGLK_01730 1.6e-120 sdaAB 4.3.1.17 E L-serine dehydratase
AAKFIGLK_01731 3.9e-130 yjjG 3.1.3.102, 3.1.3.104, 3.1.3.5, 3.8.1.2 E hydrolase
AAKFIGLK_01732 0.0 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
AAKFIGLK_01733 3.3e-209 metK 2.5.1.6 H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AAKFIGLK_01734 2.8e-171 birA 6.3.4.15 HK Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
AAKFIGLK_01735 2.1e-302 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AAKFIGLK_01736 3.1e-84 ytsP 1.8.4.14 T GAF domain-containing protein
AAKFIGLK_01737 1.1e-159 miaA 2.5.1.75 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AAKFIGLK_01738 3.2e-20 WQ51_02665 S Protein of unknown function (DUF3042)
AAKFIGLK_01741 1.1e-56 rplS J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
AAKFIGLK_01742 1.3e-208 XK27_05110 P Chloride transporter ClC family
AAKFIGLK_01743 1.2e-37 pheA 1.3.1.12, 2.3.1.79, 4.2.1.51, 5.4.99.5 E Chorismate mutase
AAKFIGLK_01744 8.6e-279 clcA P Chloride transporter, ClC family
AAKFIGLK_01745 3.9e-75 fld C Flavodoxin
AAKFIGLK_01746 2.2e-18 XK27_08880
AAKFIGLK_01747 4.7e-126 XK27_08875 O Zinc-dependent metalloprotease
AAKFIGLK_01748 3.6e-148 estA CE1 S Esterase
AAKFIGLK_01749 1.3e-309 rnjB S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AAKFIGLK_01750 8.9e-136 XK27_08845 S abc transporter atp-binding protein
AAKFIGLK_01751 2.6e-147 XK27_08840 S Belongs to the binding-protein-dependent transport system permease family
AAKFIGLK_01752 1.1e-176 XK27_08835 S ABC transporter substrate binding protein
AAKFIGLK_01753 1.7e-18 S Domain of unknown function (DUF4649)
AAKFIGLK_01754 2e-303 Q the current gene model (or a revised gene model) may contain a frame shift
AAKFIGLK_01755 2.7e-178 M Putative cell wall binding repeat
AAKFIGLK_01756 1.1e-302 S dextransucrase activity
AAKFIGLK_01757 0.0 M Putative cell wall binding repeat
AAKFIGLK_01758 1.8e-156 pdxS 4.3.3.6 H Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AAKFIGLK_01759 1.4e-104 pdxT 4.3.3.6 H Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AAKFIGLK_01760 0.0 S dextransucrase activity
AAKFIGLK_01761 2.9e-90 M Putative cell wall binding repeat
AAKFIGLK_01762 0.0 S dextransucrase activity
AAKFIGLK_01764 3.9e-87 sigH K DNA-templated transcription, initiation
AAKFIGLK_01765 2.3e-134 ykuT M mechanosensitive ion channel
AAKFIGLK_01766 5.8e-228 tig D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
AAKFIGLK_01767 1.3e-70 rpoE K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
AAKFIGLK_01768 3.7e-309 pyrG 6.3.4.2 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
AAKFIGLK_01769 8.4e-84 XK27_03960 S Protein of unknown function (DUF3013)
AAKFIGLK_01770 2.1e-76 mutT3 3.6.1.13, 3.6.1.55 L NUDIX domain
AAKFIGLK_01771 2.5e-175 prmA J Ribosomal protein L11 methyltransferase
AAKFIGLK_01772 1.1e-130 rsmE 2.1.1.193 J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
AAKFIGLK_01773 0.0 cpdB 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
AAKFIGLK_01774 3.1e-83 nrdI F Belongs to the NrdI family
AAKFIGLK_01775 0.0 relA 2.7.6.5 KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AAKFIGLK_01776 3.3e-74 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
AAKFIGLK_01777 0.0 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
AAKFIGLK_01778 1.9e-236 ilvA 4.3.1.19 E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AAKFIGLK_01779 1.9e-112 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
AAKFIGLK_01780 7.6e-104 fnr5 K Catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
AAKFIGLK_01781 4.4e-182 yhjX P Major Facilitator
AAKFIGLK_01782 9.2e-43 rpsO J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AAKFIGLK_01783 4.4e-82 V VanZ like family
AAKFIGLK_01784 1.3e-181 D nuclear chromosome segregation
AAKFIGLK_01785 1e-123 glnQ E abc transporter atp-binding protein
AAKFIGLK_01786 1.3e-271 glnP P ABC transporter
AAKFIGLK_01787 1.5e-152 uppP 3.6.1.27 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
AAKFIGLK_01788 1.4e-17 S Protein of unknown function (DUF3021)
AAKFIGLK_01789 1.6e-124 mecA NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
AAKFIGLK_01790 7.4e-182 tagO 2.7.8.33, 2.7.8.35 M transferase
AAKFIGLK_01791 1.7e-137 sufC O ABC-type transport system involved in Fe-S cluster assembly, ATPase component
AAKFIGLK_01792 1e-232 sufD O assembly protein SufD
AAKFIGLK_01793 8.8e-234 sufS 2.8.1.7, 4.4.1.16 E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AAKFIGLK_01794 9.4e-74 nifU C SUF system FeS assembly protein, NifU family
AAKFIGLK_01795 2.9e-273 sufB O assembly protein SufB
AAKFIGLK_01796 4.7e-26
AAKFIGLK_01797 1.8e-156 hslO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AAKFIGLK_01798 2.8e-182 dus J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AAKFIGLK_01799 1e-70 adcR K transcriptional
AAKFIGLK_01800 7.1e-135 adcC P ABC transporter, ATP-binding protein
AAKFIGLK_01801 1.9e-128 adcB P ABC transporter (Permease
AAKFIGLK_01802 5.5e-159 mleP2 S Transporter, auxin efflux carrier (AEC) family protein
AAKFIGLK_01803 0.0 ptsG 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G pts system
AAKFIGLK_01804 3.1e-158 rgfB 3.1.3.90 L Endonuclease/Exonuclease/phosphatase family
AAKFIGLK_01805 1.6e-257 pgi 5.3.1.9 G Belongs to the GPI family
AAKFIGLK_01806 1.4e-148 Z012_04635 K sequence-specific DNA binding
AAKFIGLK_01807 3.9e-266 V ABC transporter
AAKFIGLK_01808 6.1e-126 yeeN K transcriptional regulatory protein
AAKFIGLK_01809 9.1e-48 yajC U protein transport
AAKFIGLK_01810 9.1e-141 uppS 2.5.1.31 H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AAKFIGLK_01811 1.3e-142 cdsA 2.7.7.41 S Belongs to the CDS family
AAKFIGLK_01812 6.1e-230 rseP 3.4.21.107, 3.4.21.116 M zinc metalloprotease
AAKFIGLK_01813 0.0 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
AAKFIGLK_01814 0.0 WQ51_06230 S ABC transporter
AAKFIGLK_01815 1.4e-142 cmpC S abc transporter atp-binding protein
AAKFIGLK_01816 4.9e-42 groS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AAKFIGLK_01817 1.2e-286 groL O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
AAKFIGLK_01819 1.2e-43
AAKFIGLK_01820 1.4e-53 S TM2 domain
AAKFIGLK_01821 5.8e-163 rluA 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
AAKFIGLK_01822 0.0 pbp2A 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
AAKFIGLK_01823 2.8e-24 secE U Belongs to the SecE SEC61-gamma family
AAKFIGLK_01824 8.4e-96 nusG K Participates in transcription elongation, termination and antitermination
AAKFIGLK_01825 7.6e-64 3.1.3.27, 3.1.3.4, 3.1.3.81, 3.6.1.27 I phosphatidate phosphatase activity
AAKFIGLK_01826 4e-142 cof S Sucrose-6F-phosphate phosphohydrolase
AAKFIGLK_01827 1.7e-134 glcR K transcriptional regulator (DeoR family)
AAKFIGLK_01828 0.0 leuS 6.1.1.4 J Belongs to the class-I aminoacyl-tRNA synthetase family
AAKFIGLK_01829 7.1e-72 K helix_turn_helix multiple antibiotic resistance protein
AAKFIGLK_01830 2.6e-217 S COG1073 Hydrolases of the alpha beta superfamily
AAKFIGLK_01831 4.1e-153 cylA V abc transporter atp-binding protein
AAKFIGLK_01832 3e-132 cylB V ABC-2 type transporter
AAKFIGLK_01833 2.6e-74 K COG3279 Response regulator of the LytR AlgR family
AAKFIGLK_01834 4.8e-30 S Protein of unknown function (DUF3021)
AAKFIGLK_01835 5.8e-121 mta K Transcriptional
AAKFIGLK_01836 2.4e-119 yhcA V abc transporter atp-binding protein
AAKFIGLK_01837 3e-216 macB_2 V FtsX-like permease family
AAKFIGLK_01838 9.7e-272 pncB 6.3.4.21 H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AAKFIGLK_01839 4.1e-150 nadE 6.3.1.5 H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
AAKFIGLK_01840 2.9e-70 yhaI S Protein of unknown function (DUF805)
AAKFIGLK_01841 3.8e-254 pepC 3.4.22.40 E aminopeptidase
AAKFIGLK_01842 0.0 ponA 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
AAKFIGLK_01843 4.3e-109 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
AAKFIGLK_01844 9.8e-94 ypsA S Belongs to the UPF0398 family
AAKFIGLK_01845 7.3e-50 gpsB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
AAKFIGLK_01846 7.4e-222 rlmL 2.1.1.173, 2.1.1.264 L Belongs to the methyltransferase superfamily
AAKFIGLK_01847 3.3e-278 mapZ D Early cell division protein that marks the future cell division site and supports proper FtsZ ring positioning
AAKFIGLK_01848 0.0 snf 2.7.11.1 L Superfamily II DNA RNA helicases, SNF2 family'
AAKFIGLK_01849 4.8e-22
AAKFIGLK_01850 2e-255 mpl 6.3.2.4, 6.3.2.45, 6.3.2.8 M Belongs to the MurCDEF family
AAKFIGLK_01851 1.2e-85 XK27_09675 K histone acetyltransferase HPA2 and related acetyltransferases
AAKFIGLK_01852 1.2e-288 mltG ADL Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AAKFIGLK_01853 1.2e-77 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
AAKFIGLK_01854 1.4e-162 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
AAKFIGLK_01855 1.1e-43 acyP 3.6.1.7 C Belongs to the acylphosphatase family
AAKFIGLK_01856 2.3e-128 spoU 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AAKFIGLK_01857 7.3e-94 XK27_09705 6.1.1.14 S HD superfamily hydrolase
AAKFIGLK_01858 2.1e-99 ybhL S Belongs to the BI1 family
AAKFIGLK_01859 4.2e-12 ycdA S Domain of unknown function (DUF4352)
AAKFIGLK_01860 6.9e-242 lysA 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
AAKFIGLK_01861 4.1e-90 K transcriptional regulator
AAKFIGLK_01862 1.6e-36 yneF S UPF0154 protein
AAKFIGLK_01863 3.4e-149 murI 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
AAKFIGLK_01864 6.2e-182 rdgB 3.6.1.66, 5.1.1.3 F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AAKFIGLK_01865 1.6e-96 XK27_09740 S Phosphoesterase
AAKFIGLK_01866 2.7e-85 ykuL S CBS domain
AAKFIGLK_01867 1e-126 xerD L tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site
AAKFIGLK_01868 4.2e-119 scpA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AAKFIGLK_01869 6.9e-96 scpB D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AAKFIGLK_01870 3.4e-132 rluB 5.4.99.19, 5.4.99.21, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
AAKFIGLK_01871 4.6e-258 trkH P Cation transport protein
AAKFIGLK_01872 1e-246 trkA P Potassium transporter peripheral membrane component
AAKFIGLK_01873 6.1e-96 trmL 2.1.1.207 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
AAKFIGLK_01874 1.2e-81 ribU U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AAKFIGLK_01875 1.4e-89 bcrC 3.6.1.27 I Membrane-associated phospholipid phosphatase
AAKFIGLK_01876 7.1e-156 K sequence-specific DNA binding
AAKFIGLK_01877 0.0 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
AAKFIGLK_01878 2.4e-53 yhaI L Membrane
AAKFIGLK_01879 2.1e-244 S Domain of unknown function (DUF4173)
AAKFIGLK_01880 2.6e-94 ureI S AmiS/UreI family transporter
AAKFIGLK_01881 7.6e-46 ureA 3.5.1.5 E Belongs to the urease gamma subunit family
AAKFIGLK_01882 7.8e-54 ureB 3.5.1.5 E Belongs to the urease beta subunit family
AAKFIGLK_01883 0.0 ureC 3.5.1.5 E Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family
AAKFIGLK_01884 6.6e-78 ureE O enzyme active site formation
AAKFIGLK_01885 1.7e-128 ureF O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
AAKFIGLK_01886 9.5e-112 ureG KO Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AAKFIGLK_01887 3.7e-159 ureD O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
AAKFIGLK_01888 2.1e-177 cbiM P PDGLE domain
AAKFIGLK_01889 6.4e-137 P cobalt transport protein
AAKFIGLK_01890 2.9e-128 cbiO P ABC transporter
AAKFIGLK_01891 1.8e-137 ET ABC transporter substrate-binding protein
AAKFIGLK_01892 7.8e-163 metQ M Belongs to the NlpA lipoprotein family
AAKFIGLK_01893 3.6e-260 dapE 3.5.1.18 E COG0624, acetylornithine deacetylase succinyl-diaminopimelate desuccinylase and related deacylases
AAKFIGLK_01894 6e-186 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AAKFIGLK_01895 1.2e-99 metI P ABC transporter (Permease
AAKFIGLK_01896 1.5e-209 sstT E Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AAKFIGLK_01897 1e-156 salL 2.5.1.63, 2.5.1.94 S S-adenosyl-l-methionine hydroxide adenosyltransferase
AAKFIGLK_01898 6.7e-93 S UPF0397 protein
AAKFIGLK_01899 1.5e-308 ykoD P abc transporter atp-binding protein
AAKFIGLK_01900 2.5e-147 cbiQ P cobalt transport
AAKFIGLK_01901 1.1e-116 ktrA P COG0569 K transport systems, NAD-binding component
AAKFIGLK_01902 2.9e-233 P COG0168 Trk-type K transport systems, membrane components
AAKFIGLK_01903 1.4e-127 rsmG 2.1.1.170 J Ribosomal RNA small subunit methyltransferase G
AAKFIGLK_01904 3.1e-90 yceD K metal-binding, possibly nucleic acid-binding protein
AAKFIGLK_01905 7.9e-123 T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
AAKFIGLK_01906 6.6e-279 T PhoQ Sensor
AAKFIGLK_01907 3e-81 nrdR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AAKFIGLK_01908 2e-211 dnaB L Replication initiation and membrane attachment
AAKFIGLK_01909 1.3e-165 dnaI L Primosomal protein DnaI
AAKFIGLK_01910 7.4e-247 der 1.1.1.399, 1.1.1.95 S GTPase that plays an essential role in the late steps of ribosome biogenesis
AAKFIGLK_01911 6.1e-106
AAKFIGLK_01912 2e-228 serS 6.1.1.11 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AAKFIGLK_01913 6.3e-58 manO S protein conserved in bacteria
AAKFIGLK_01914 9.3e-164 manN G PTS system mannose fructose sorbose family IID component
AAKFIGLK_01915 3e-121 manM G pts system
AAKFIGLK_01916 2.9e-166 manL 2.7.1.191 G pts system
AAKFIGLK_01917 2.6e-67 manO S Protein conserved in bacteria
AAKFIGLK_01918 3.6e-163 manN G PTS system mannose fructose sorbose family IID component
AAKFIGLK_01919 4.7e-135 manY G pts system
AAKFIGLK_01920 6.2e-169 manL 2.7.1.191 G pts system
AAKFIGLK_01921 1.5e-129 XK27_00940 1.2.1.70, 3.5.1.9 S Metal-dependent hydrolase
AAKFIGLK_01922 1e-153 yitU 3.1.3.104 S hydrolases of the HAD superfamily
AAKFIGLK_01923 6.2e-247 pbuO S permease
AAKFIGLK_01924 2.7e-76 ydiB 2.7.1.221, 5.1.1.1 M ATPase or kinase
AAKFIGLK_01925 2.4e-87 XK27_05885 2.3.1.82 M phosphinothricin N-acetyltransferase activity
AAKFIGLK_01926 2.8e-187 brpA K Transcriptional
AAKFIGLK_01927 2.3e-81 rimP S Required for maturation of 30S ribosomal subunits
AAKFIGLK_01928 2.4e-196 nusA K Participates in both transcription termination and antitermination
AAKFIGLK_01929 1e-47 ylxR K Nucleic-acid-binding protein implicated in transcription termination
AAKFIGLK_01930 1.4e-41 ylxQ J ribosomal protein
AAKFIGLK_01931 0.0 infB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AAKFIGLK_01932 8.6e-57 rbfA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AAKFIGLK_01933 8.5e-99 yvdD 3.2.2.10 S Belongs to the LOG family
AAKFIGLK_01934 5.1e-189 femA 2.3.2.16, 2.3.2.17, 2.3.2.18 V protein involved in methicillin resistance
AAKFIGLK_01935 1.9e-267 murE 6.3.2.13, 6.3.2.7 M to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AAKFIGLK_01936 3.2e-281 ytgP S Membrane protein involved in the export of O-antigen and teichoic acid
AAKFIGLK_01937 0.0 pacL 3.6.3.8, 3.6.3.9 P cation transport ATPase
AAKFIGLK_01938 3.3e-200 metB 2.5.1.48, 4.4.1.8 E cystathionine
AAKFIGLK_01939 9.6e-222 malY 4.4.1.8 E COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
AAKFIGLK_01940 0.0 3.2.1.26, 3.2.1.65 GH32 G Belongs to the glycosyl hydrolase 32 family
AAKFIGLK_01941 0.0 sacB 2.4.1.10, 2.4.1.9, 3.2.1.26 GH32,GH68 G Belongs to the glycosyl hydrolase 68 family
AAKFIGLK_01942 5.7e-112 upp 2.4.2.9 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AAKFIGLK_01943 3.7e-105 clpP 3.4.21.92 OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
AAKFIGLK_01944 3.2e-72 ylbF S Belongs to the UPF0342 family
AAKFIGLK_01945 2.1e-45 ylbG S UPF0298 protein
AAKFIGLK_01946 8.5e-210 livJ E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component
AAKFIGLK_01947 1.2e-144 livH E Belongs to the binding-protein-dependent transport system permease family
AAKFIGLK_01948 4.9e-139 livM E Belongs to the binding-protein-dependent transport system permease family
AAKFIGLK_01949 4e-136 livG E COG0411 ABC-type branched-chain amino acid transport systems, ATPase component
AAKFIGLK_01950 5.6e-124 livF E COG0410 ABC-type branched-chain amino acid transport systems, ATPase component
AAKFIGLK_01951 9.6e-110 acuB S CBS domain
AAKFIGLK_01952 6.7e-139 glnQ 3.6.3.21 E abc transporter atp-binding protein
AAKFIGLK_01953 5e-111 tcyB_2 P ABC transporter (permease)
AAKFIGLK_01954 3.7e-68 3.4.21.110 D Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AAKFIGLK_01955 2.2e-10
AAKFIGLK_01956 3.9e-191 XK27_10075 S abc transporter atp-binding protein
AAKFIGLK_01957 2.4e-34 2.4.1.21 GT5 M Right handed beta helix region
AAKFIGLK_01958 5.3e-176 spd F DNA RNA non-specific endonuclease
AAKFIGLK_01959 7.7e-92 lemA S LemA family
AAKFIGLK_01960 3.4e-134 htpX O Belongs to the peptidase M48B family
AAKFIGLK_01961 9.1e-113 sirR K iron dependent repressor
AAKFIGLK_01962 3.3e-172 sitA P Belongs to the bacterial solute-binding protein 9 family
AAKFIGLK_01963 8.7e-132 mtsC P ABC-type Mn2 Zn2 transport systems, permease components
AAKFIGLK_01964 5.6e-127 sitB 3.6.3.35 P ABC transporter, ATP-binding protein
AAKFIGLK_01965 2.1e-74 S Psort location CytoplasmicMembrane, score
AAKFIGLK_01966 6.2e-64 S Domain of unknown function (DUF4430)
AAKFIGLK_01967 0.0 ppc 4.1.1.31 H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle

eggNOG-mapper v2 (Database: eggNOG v5.0, Jul. 2018 release)