ORF_ID e_value Gene_name EC_number CAZy COGs Description
NEBGOCFH_00012 5.3e-11
NEBGOCFH_00018 5.5e-139 mreC M Involved in formation and maintenance of cell shape
NEBGOCFH_00019 8.2e-88 mreD M Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
NEBGOCFH_00020 5.5e-94 usp 3.5.1.28 CBM50 S CHAP domain
NEBGOCFH_00021 1.2e-174 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NEBGOCFH_00022 2.9e-218 araT 2.6.1.1 E Aminotransferase
NEBGOCFH_00023 7e-144 recO L Involved in DNA repair and RecF pathway recombination
NEBGOCFH_00024 1.3e-179 plsX 2.3.1.15 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
NEBGOCFH_00025 4.2e-34 acpP1 IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
NEBGOCFH_00026 3.4e-129 purC 4.1.1.21, 4.3.2.2, 6.3.2.6 F Belongs to the SAICAR synthetase family
NEBGOCFH_00027 0.0 purL 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NEBGOCFH_00028 1.3e-276 purF 2.4.2.14 F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NEBGOCFH_00029 4.8e-185 purM 6.3.3.1, 6.3.4.13 F Phosphoribosylformylglycinamidine cyclo-ligase
NEBGOCFH_00030 1.4e-101 purN 2.1.2.2 F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NEBGOCFH_00031 1.5e-294 purH 2.1.2.3, 3.5.4.10 F Bifunctional purine biosynthesis protein PurH
NEBGOCFH_00032 1e-90 L transposase activity
NEBGOCFH_00033 3.5e-50 L transposition
NEBGOCFH_00034 2e-32 L Integrase core domain protein
NEBGOCFH_00035 2.3e-161 S CHAP domain
NEBGOCFH_00036 3.4e-241 purD 6.3.4.13 F Belongs to the GARS family
NEBGOCFH_00037 4.9e-76 purE 5.4.99.18 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NEBGOCFH_00038 3.8e-204 purK 6.3.4.18 F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NEBGOCFH_00039 3.2e-46 1.1.1.169 H Ketopantoate reductase
NEBGOCFH_00040 5.6e-86 1.1.1.169 H Ketopantoate reductase
NEBGOCFH_00041 6.6e-34
NEBGOCFH_00042 8.7e-248 purB 4.3.2.2 F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NEBGOCFH_00043 0.0 argS 6.1.1.19 J Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
NEBGOCFH_00044 8.2e-70 argR K Regulates arginine biosynthesis genes
NEBGOCFH_00045 1e-57 ymcA 3.6.3.21 S Belongs to the UPF0342 family
NEBGOCFH_00046 0.0 mutS L that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NEBGOCFH_00047 1.1e-77 S Protein of unknown function (DUF3021)
NEBGOCFH_00048 5.4e-69 K LytTr DNA-binding domain
NEBGOCFH_00050 0.0 mutL L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NEBGOCFH_00052 7.8e-103 ruvA 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
NEBGOCFH_00053 2.4e-106 tag 3.2.2.20 L 3-methyladenine DNA glycosylase
NEBGOCFH_00054 6.5e-232 cinA 3.5.1.42 S Belongs to the CinA family
NEBGOCFH_00055 4.7e-205 recA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NEBGOCFH_00056 2.3e-66 spxA_2 1.20.4.1 P Belongs to the ArsC family
NEBGOCFH_00057 2.4e-256 lysC 2.7.2.4 E Belongs to the aspartokinase family
NEBGOCFH_00058 1.9e-115 S Haloacid dehalogenase-like hydrolase
NEBGOCFH_00059 2.4e-139 phaB 5.3.3.14, 5.3.3.18 I Belongs to the enoyl-CoA hydratase isomerase family
NEBGOCFH_00060 4e-72 marR K Transcriptional regulator, MarR family
NEBGOCFH_00061 2.3e-173 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NEBGOCFH_00062 3.3e-30 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
NEBGOCFH_00063 5.8e-172 fabK 1.3.1.9 S 2-Nitropropane dioxygenase
NEBGOCFH_00064 8.5e-165 fabD 2.3.1.39 I Malonyl CoA-acyl carrier protein transacylase
NEBGOCFH_00065 1.6e-126 IQ reductase
NEBGOCFH_00066 2.6e-233 fabF 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
NEBGOCFH_00067 7.7e-56 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
NEBGOCFH_00068 1.5e-71 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
NEBGOCFH_00069 1.7e-257 accC 6.3.4.14, 6.4.1.2 I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
NEBGOCFH_00070 1.6e-160 accD 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NEBGOCFH_00071 3e-139 accA 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
NEBGOCFH_00072 4.7e-90 luxS 4.4.1.21 H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
NEBGOCFH_00073 9.9e-91 tnp L Transposase
NEBGOCFH_00074 1.4e-60 S Bacterial PH domain
NEBGOCFH_00078 1.5e-27 S Antidote-toxin recognition MazE, bacterial antitoxin
NEBGOCFH_00079 7.4e-155 L COG2801 Transposase and inactivated derivatives
NEBGOCFH_00080 6.6e-38 L transposase activity
NEBGOCFH_00081 8.1e-203 rny D Endoribonuclease that initiates mRNA decay
NEBGOCFH_00082 1.8e-84 L Transposase
NEBGOCFH_00083 5.6e-114 fruR K transcriptional
NEBGOCFH_00084 5.5e-164 pfkB 2.7.1.11, 2.7.1.56 H Belongs to the carbohydrate kinase PfkB family. LacC subfamily
NEBGOCFH_00085 3.9e-54 fruA 2.7.1.202 GT PTS system, Lactose/Cellobiose specific IIB subunit
NEBGOCFH_00086 2.2e-49 fruA 2.7.1.202 GT PTS system, Lactose/Cellobiose specific IIB subunit
NEBGOCFH_00087 2.7e-126 fruA 2.7.1.202 G phosphotransferase system
NEBGOCFH_00088 5.3e-35 fruA 2.7.1.202 G phosphotransferase system
NEBGOCFH_00089 1.4e-261 gor 1.8.1.7 C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NEBGOCFH_00090 3.1e-242 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
NEBGOCFH_00092 6.1e-213 iscS2 2.8.1.7 E Cysteine sulfinate desulfinase cysteine desulfurase and related enzymes
NEBGOCFH_00093 8e-227 thiI 2.8.1.4 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NEBGOCFH_00094 5.5e-294 gtf1 2.4.1.52 GT4 M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
NEBGOCFH_00095 8e-257 gtf2 M A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1
NEBGOCFH_00096 6.4e-29 2.3.1.128 K acetyltransferase
NEBGOCFH_00097 4.5e-49 rplU J This protein binds to 23S rRNA in the presence of protein L20
NEBGOCFH_00098 1.5e-46 rpmA J Belongs to the bacterial ribosomal protein bL27 family
NEBGOCFH_00099 1.7e-133 ydaF_2 J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NEBGOCFH_00100 2.6e-64 WQ51_03320 S cog cog4835
NEBGOCFH_00101 9.8e-91 XK27_08360 S EDD domain protein, DegV family
NEBGOCFH_00102 3e-139 dapB 1.17.1.8 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
NEBGOCFH_00103 2.6e-222 cca 2.7.7.19, 2.7.7.72 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
NEBGOCFH_00104 0.0 yfmR S abc transporter atp-binding protein
NEBGOCFH_00105 1.6e-24 U response to pH
NEBGOCFH_00106 1.1e-141 3.6.1.13, 3.6.1.55 F AdP-ribose pyrophosphatase
NEBGOCFH_00107 1.7e-212 nadD 2.7.1.22, 2.7.7.1, 2.7.7.18, 3.6.1.55 H adenylyltransferase
NEBGOCFH_00108 1.8e-256 gdhA 1.4.1.4 E Belongs to the Glu Leu Phe Val dehydrogenases family
NEBGOCFH_00109 1e-69 def_1 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins
NEBGOCFH_00110 1.9e-77 K DNA-binding transcription factor activity
NEBGOCFH_00111 0.0 lmrA1 V abc transporter atp-binding protein
NEBGOCFH_00112 0.0 lmrA2 V abc transporter atp-binding protein
NEBGOCFH_00113 5.4e-45 K Acetyltransferase (GNAT) family
NEBGOCFH_00114 3.2e-78 sptS 2.7.13.3 T Histidine kinase
NEBGOCFH_00115 4.9e-131 pyrH 2.7.4.22 F Catalyzes the reversible phosphorylation of UMP to UDP
NEBGOCFH_00116 1.3e-91 frr J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
NEBGOCFH_00117 5.3e-161 cvfB S Protein conserved in bacteria
NEBGOCFH_00118 7.4e-35 yozE S Belongs to the UPF0346 family
NEBGOCFH_00119 4.3e-117 sip M LysM domain protein
NEBGOCFH_00120 1e-190 phoH T phosphate starvation-inducible protein PhoH
NEBGOCFH_00124 0.0 metG 6.1.1.10, 6.1.1.20 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NEBGOCFH_00125 1.8e-164 K transcriptional regulator (lysR family)
NEBGOCFH_00126 1.4e-186 coiA 3.6.4.12 S Competence protein
NEBGOCFH_00127 0.0 pepF E oligoendopeptidase F
NEBGOCFH_00128 5.4e-127 yrrM 2.1.1.104 S O-Methyltransferase
NEBGOCFH_00129 1.1e-166 prsA 3.1.3.16, 5.2.1.8 O peptidyl-prolyl cis-trans isomerase activity
NEBGOCFH_00130 0.0 alaS 6.1.1.7 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NEBGOCFH_00131 7.9e-24 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
NEBGOCFH_00132 2.9e-153 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
NEBGOCFH_00133 1.8e-30 3.4.17.14, 3.5.1.28 NU amidase activity
NEBGOCFH_00134 7.9e-88 3.4.17.14, 3.5.1.28 NU amidase activity
NEBGOCFH_00135 1.2e-146 cnhA 3.5.1.3 S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
NEBGOCFH_00136 5.3e-228 mtnE 2.6.1.83 E mutations do not affect methionine salvage in vivo however
NEBGOCFH_00137 1.5e-191 argC 1.2.1.38 E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NEBGOCFH_00138 1.5e-222 argJ 2.3.1.1, 2.3.1.35, 2.7.2.8 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NEBGOCFH_00139 1.9e-130 argB 2.7.2.8 E Belongs to the acetylglutamate kinase family. ArgB subfamily
NEBGOCFH_00140 4.8e-210 argD 2.6.1.11, 2.6.1.17 E acetylornithine aminotransferase
NEBGOCFH_00141 4.1e-132 yxkH G deacetylase
NEBGOCFH_00142 1.8e-237 hom 1.1.1.3, 2.7.2.4 E homoserine dehydrogenase
NEBGOCFH_00143 2.8e-154 thrB 2.7.1.39 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
NEBGOCFH_00144 1.2e-152 rarD S Transporter
NEBGOCFH_00145 2.2e-15 T peptidase
NEBGOCFH_00146 8.9e-14 coiA 3.6.4.12 S Competence protein
NEBGOCFH_00147 4.1e-112 S COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NEBGOCFH_00148 8.3e-75 2.3.1.128, 5.2.1.8 J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NEBGOCFH_00149 0.0 valS 6.1.1.9 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
NEBGOCFH_00150 6e-118 S Domain of unknown function (DUF1837)
NEBGOCFH_00151 0.0 yfjK F helicase superfamily c-terminal domain
NEBGOCFH_00152 5.3e-34
NEBGOCFH_00153 3.4e-209 dcm 2.1.1.37 H cytosine-specific methyltransferase
NEBGOCFH_00154 1.1e-265
NEBGOCFH_00155 1.4e-16 atpE C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NEBGOCFH_00156 1.6e-123 atpB C it plays a direct role in the translocation of protons across the membrane
NEBGOCFH_00157 2.3e-76 atpF C ATP synthase F(0) sector subunit b
NEBGOCFH_00158 1e-85 atpH C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NEBGOCFH_00159 3.8e-279 atpA 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NEBGOCFH_00160 2.5e-158 atpG C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NEBGOCFH_00161 2.7e-263 atpD 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NEBGOCFH_00162 5.2e-67 atpC C Produces ATP from ADP in the presence of a proton gradient across the membrane
NEBGOCFH_00163 6.8e-229 ftsW D Belongs to the SEDS family
NEBGOCFH_00164 9.5e-225 tuf J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NEBGOCFH_00165 1.4e-136 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
NEBGOCFH_00166 2.8e-111 tmk 2.7.4.9 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NEBGOCFH_00167 5.4e-161 holB 2.7.7.7 L dna polymerase iii
NEBGOCFH_00168 1.2e-135 yaaT S stage 0 sporulation protein
NEBGOCFH_00169 9.5e-55 yabA L Involved in initiation control of chromosome replication
NEBGOCFH_00170 6.6e-159 rsmI 2.1.1.198 H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NEBGOCFH_00171 6.8e-226 amt P Ammonium Transporter
NEBGOCFH_00172 1.1e-53 glnB K Belongs to the P(II) protein family
NEBGOCFH_00173 1.3e-103 mur1 NU mannosyl-glycoprotein
NEBGOCFH_00174 5.8e-149 XK27_04800 S Sucrose-6F-phosphate phosphohydrolase
NEBGOCFH_00175 7.7e-69 nptA P sodium-dependent phosphate transmembrane transporter activity
NEBGOCFH_00176 2.1e-221 nagA 3.5.1.25 G Belongs to the metallo-dependent hydrolases superfamily. NagA family
NEBGOCFH_00177 4.9e-51
NEBGOCFH_00178 2.2e-25
NEBGOCFH_00179 3.9e-60
NEBGOCFH_00180 6.1e-63 S membrane
NEBGOCFH_00181 4.8e-176 glyQ 6.1.1.14 J glycyl-tRNA synthetase alpha subunit
NEBGOCFH_00182 0.0 glyS 6.1.1.14 J Glycyl-tRNA synthetase beta subunit
NEBGOCFH_00183 4.5e-39 ynzC S UPF0291 protein
NEBGOCFH_00184 1.8e-254 cycA E permease
NEBGOCFH_00185 1.1e-09 uvrX 2.7.7.7 L ImpB mucB samB family
NEBGOCFH_00186 1.7e-70 pts33BCA G pts system
NEBGOCFH_00187 1.1e-76 pts33BCA G pts system
NEBGOCFH_00188 4.7e-68 pts33BCA G pts system
NEBGOCFH_00189 3.2e-141 ppiA 5.2.1.8 O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NEBGOCFH_00194 1.8e-167 fhuR K transcriptional regulator (lysR family)
NEBGOCFH_00195 8.8e-78 lspA 3.4.23.36 MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NEBGOCFH_00196 5e-162 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
NEBGOCFH_00197 3.7e-88 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NEBGOCFH_00198 4.9e-227 pyrP F uracil Permease
NEBGOCFH_00199 1e-173 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
NEBGOCFH_00200 5.5e-211 carA 6.3.5.5 F carbamoyl-phosphate synthetase glutamine chain
NEBGOCFH_00201 0.0 carB 6.3.5.5 F carbamoyl-phosphate synthetase ammonia chain
NEBGOCFH_00202 4.6e-132 2.1.1.223 S Putative SAM-dependent methyltransferase
NEBGOCFH_00203 3.3e-18 acrA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NEBGOCFH_00204 6.9e-37 acrA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NEBGOCFH_00205 3.6e-35 V efflux transmembrane transporter activity
NEBGOCFH_00206 1.7e-29 V efflux transmembrane transporter activity
NEBGOCFH_00207 8.2e-28 ytrF V efflux transmembrane transporter activity
NEBGOCFH_00208 8.2e-77 rplJ J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NEBGOCFH_00209 3e-52 rplL J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
NEBGOCFH_00210 9.1e-110 L Transposase
NEBGOCFH_00211 2.3e-111 L Transposase
NEBGOCFH_00212 5.4e-19 L Integrase core domain
NEBGOCFH_00213 5.9e-98 hrtB V MacB-like periplasmic core domain
NEBGOCFH_00217 3e-92 S MucBP domain
NEBGOCFH_00218 1.9e-49 M YSIRK type signal peptide
NEBGOCFH_00219 4.8e-142 M the current gene model (or a revised gene model) may contain a
NEBGOCFH_00221 0.0 mdlB V abc transporter atp-binding protein
NEBGOCFH_00222 0.0 lmrA V abc transporter atp-binding protein
NEBGOCFH_00223 6e-199 queA 2.4.99.17 J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NEBGOCFH_00224 3.4e-121 nagB 3.1.1.31, 3.5.99.6 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
NEBGOCFH_00225 3.3e-215 2.7.13.3 T signal transduction protein with a C-terminal ATPase domain
NEBGOCFH_00226 1.3e-131 rr02 KT response regulator
NEBGOCFH_00227 8.5e-173 2.7.7.73, 2.7.7.80 H Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
NEBGOCFH_00228 6.2e-34 2.7.7.73, 2.7.7.80 H Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
NEBGOCFH_00229 1.1e-167 V ABC transporter
NEBGOCFH_00230 5.4e-122 sagI S ABC-2 type transporter
NEBGOCFH_00231 1e-195 yceA S Belongs to the UPF0176 family
NEBGOCFH_00232 4.3e-22
NEBGOCFH_00233 4.1e-144 deoD_1 2.4.2.3 F Phosphorylase superfamily
NEBGOCFH_00234 5.6e-113 S VIT family
NEBGOCFH_00235 7.4e-132 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
NEBGOCFH_00236 2.4e-217 hipO 3.5.1.47 E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
NEBGOCFH_00237 3.4e-17 ald 1.4.1.1 E alanine dehydrogenase activity
NEBGOCFH_00238 1.5e-45 ald 1.4.1.1 C Belongs to the AlaDH PNT family
NEBGOCFH_00239 5.7e-247 merA 1.16.1.1 C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NEBGOCFH_00240 4.6e-105 GBS0088 J protein conserved in bacteria
NEBGOCFH_00241 1.7e-138 mvk 1.1.1.88, 2.3.3.10, 2.7.1.36 I mevalonate kinase
NEBGOCFH_00242 1.9e-172 mvaD 4.1.1.33 I diphosphomevalonate decarboxylase
NEBGOCFH_00243 3.3e-178 mvaK2 2.7.1.36, 2.7.1.43, 2.7.4.2 I GHMP kinases N terminal domain
NEBGOCFH_00244 2.6e-191 fni 1.1.1.88, 5.3.3.2 C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
NEBGOCFH_00245 5.6e-253 glmU 2.3.1.157, 2.7.7.23 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NEBGOCFH_00246 4.5e-97 nudF 3.6.1.13 L AdP-ribose pyrophosphatase
NEBGOCFH_00247 2.5e-21
NEBGOCFH_00248 2e-118 mtnN 3.2.2.9 E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NEBGOCFH_00250 3.5e-07 U protein secretion
NEBGOCFH_00251 2.3e-49 U protein secretion
NEBGOCFH_00252 1.9e-11 U protein secretion
NEBGOCFH_00253 1.1e-192 dgs 2.4.1.208 GT4 M Glycosyltransferase, group 1 family protein
NEBGOCFH_00254 4.4e-247 mgs 2.4.1.337 GT4 M Glycosyltransferase, group 1 family protein
NEBGOCFH_00256 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NEBGOCFH_00257 1.9e-48 S hydrolases or acyltransferases (alpha beta hydrolase superfamily)
NEBGOCFH_00258 3.6e-70 S hydrolases or acyltransferases (alpha beta hydrolase superfamily)
NEBGOCFH_00259 2.4e-161 S Protein of unknown function (DUF3114)
NEBGOCFH_00260 1.2e-22 S Protein of unknown function (DUF3114)
NEBGOCFH_00261 1.5e-118 yqfA K protein, Hemolysin III
NEBGOCFH_00262 1e-25 K hmm pf08876
NEBGOCFH_00263 2.7e-233 mvaA 1.1.1.34, 1.1.1.88, 2.3.1.9 C Belongs to the HMG-CoA reductase family
NEBGOCFH_00264 1.7e-218 mvaS 2.3.3.10 I synthase
NEBGOCFH_00265 2.2e-167 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NEBGOCFH_00266 3.4e-91 folA 1.5.1.3, 1.5.1.47, 2.1.1.45, 3.5.4.12 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NEBGOCFH_00267 9.7e-22
NEBGOCFH_00268 5.7e-225 clpX O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NEBGOCFH_00269 3e-110 engB D Necessary for normal cell division and for the maintenance of normal septation
NEBGOCFH_00270 1.9e-248 mmuP E amino acid
NEBGOCFH_00271 4.4e-172 mmuM 1.5.1.20, 2.1.1.10 H Homocysteine
NEBGOCFH_00272 5.5e-29 S Domain of unknown function (DUF1912)
NEBGOCFH_00273 4.9e-15 L Helix-hairpin-helix DNA-binding motif class 1
NEBGOCFH_00274 7.1e-102 plsY 2.3.1.15, 3.5.1.104 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
NEBGOCFH_00275 0.0 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
NEBGOCFH_00276 0.0 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
NEBGOCFH_00277 2.4e-200 ilvE 2.6.1.42 E Aminotransferase
NEBGOCFH_00278 4.8e-16 S Protein of unknown function (DUF2969)
NEBGOCFH_00281 8.4e-205 rpsA 1.17.7.4 J ribosomal protein S1
NEBGOCFH_00283 6.4e-69 L Transposase
NEBGOCFH_00285 2.6e-101 S Domain of Unknown Function with PDB structure (DUF3862)
NEBGOCFH_00286 6.1e-70 M Pfam SNARE associated Golgi protein
NEBGOCFH_00287 1.3e-232 murN 2.3.2.10, 2.3.2.16 V FemAB family
NEBGOCFH_00288 9.3e-59 S oxidoreductase
NEBGOCFH_00289 9.7e-66 S oxidoreductase
NEBGOCFH_00290 3.7e-48 XK27_09445 S Domain of unknown function (DUF1827)
NEBGOCFH_00291 1.8e-86 mutT 3.5.4.33, 3.6.1.13, 3.6.1.55 L Belongs to the Nudix hydrolase family
NEBGOCFH_00292 0.0 clpE O Belongs to the ClpA ClpB family
NEBGOCFH_00293 6.3e-182 argF 2.1.3.3 E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NEBGOCFH_00294 1.3e-34 ykuJ S protein conserved in bacteria
NEBGOCFH_00295 7.5e-118 WQ51_01820 P Binding-protein-dependent transport system inner membrane component
NEBGOCFH_00296 4.2e-130 glnQ 3.6.3.21 E abc transporter atp-binding protein
NEBGOCFH_00297 1.1e-78 feoA P FeoA domain protein
NEBGOCFH_00298 0.0 feoB P transporter of a GTP-driven Fe(2 ) uptake system
NEBGOCFH_00299 6.6e-08
NEBGOCFH_00300 1.5e-35 yugF I carboxylic ester hydrolase activity
NEBGOCFH_00301 7.5e-23 I Alpha/beta hydrolase family
NEBGOCFH_00302 3.9e-156 folD 1.5.1.5, 3.5.4.9 F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NEBGOCFH_00303 7.8e-149 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NEBGOCFH_00304 0.0 pbp2b 3.4.16.4 M penicillin-binding protein
NEBGOCFH_00305 2.2e-105 recR L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NEBGOCFH_00306 1.7e-63 licT K transcriptional antiterminator
NEBGOCFH_00307 6.8e-53 licT K transcriptional antiterminator
NEBGOCFH_00308 5.9e-88 ybeY 2.6.99.2, 3.5.4.5 S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NEBGOCFH_00309 1.7e-64 dgkA 2.7.1.107, 2.7.1.66 M Diacylglycerol kinase
NEBGOCFH_00310 1.3e-165 era M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NEBGOCFH_00311 1.9e-155 fpg 3.2.2.23, 4.2.99.18 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
NEBGOCFH_00312 1.1e-104 coaE 2.7.1.24, 3.2.2.23, 4.2.99.18 GH23 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NEBGOCFH_00313 2.5e-220 mdtG EGP Major facilitator Superfamily
NEBGOCFH_00314 2e-33 secG U Preprotein translocase subunit SecG
NEBGOCFH_00315 0.0 rnr J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
NEBGOCFH_00316 1.1e-80 smpB O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
NEBGOCFH_00317 9.6e-277 ppiB 5.2.1.8 G PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NEBGOCFH_00318 1.7e-63 yugI 5.3.1.9 J RNA binding protein, contains ribosomal protein S1 domain
NEBGOCFH_00319 4.2e-211 pepQ 3.4.13.9 E Belongs to the peptidase M24B family
NEBGOCFH_00320 4.4e-183 ccpA K Catabolite control protein A
NEBGOCFH_00321 6.2e-21 yyaQ S YjbR
NEBGOCFH_00322 8.4e-142 yyaQ S YjbR
NEBGOCFH_00323 1.6e-205 glxK 2.7.1.165 G Belongs to the glycerate kinase type-1 family
NEBGOCFH_00324 1e-78 yueI S Protein of unknown function (DUF1694)
NEBGOCFH_00325 9.6e-247 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
NEBGOCFH_00326 2e-25 WQ51_00785
NEBGOCFH_00327 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
NEBGOCFH_00328 2e-219 ywbD 2.1.1.191 J Methyltransferase
NEBGOCFH_00329 8.6e-122 aroD 1.1.1.25, 4.2.1.10 E Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
NEBGOCFH_00330 1.7e-162 aroE 1.1.1.25 E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NEBGOCFH_00331 1.3e-201 aroB 2.7.1.71, 4.2.3.4 E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NEBGOCFH_00332 4.5e-219 aroC 4.2.3.5 E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NEBGOCFH_00333 2.2e-207 tyrA 1.3.1.12, 1.3.1.43 E prephenate dehydrogenase
NEBGOCFH_00334 3.2e-53 yheA S Belongs to the UPF0342 family
NEBGOCFH_00335 3e-173 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
NEBGOCFH_00336 1.4e-234 aroA 1.3.1.12, 1.3.1.43, 2.5.1.19 E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
NEBGOCFH_00337 1.7e-87 aroK 1.1.1.25, 2.7.1.71, 4.2.1.10, 4.2.3.4 F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NEBGOCFH_00338 2.3e-153 pheA 4.2.1.51 E Prephenate dehydratase
NEBGOCFH_00339 6.4e-252 msrR K Transcriptional regulator
NEBGOCFH_00340 3.5e-150 ydiA P C4-dicarboxylate transporter malic acid transport protein
NEBGOCFH_00341 2.4e-203 I acyl-CoA dehydrogenase
NEBGOCFH_00342 5.9e-97 mip S hydroperoxide reductase activity
NEBGOCFH_00343 2.8e-257 rumA 2.1.1.190 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NEBGOCFH_00344 8.9e-20
NEBGOCFH_00345 7e-46
NEBGOCFH_00346 1e-31 K Cro/C1-type HTH DNA-binding domain
NEBGOCFH_00347 7.8e-50 dam 2.1.1.72 L D12 class N6 adenine-specific DNA methyltransferase
NEBGOCFH_00348 5.7e-34 estA E GDSL-like Lipase/Acylhydrolase
NEBGOCFH_00349 3.3e-96
NEBGOCFH_00350 0.0 cas9 L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
NEBGOCFH_00351 3.2e-172 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
NEBGOCFH_00352 3.1e-53 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
NEBGOCFH_00353 1.3e-185 S CRISPR-associated protein Csn2 subfamily St
NEBGOCFH_00354 2.9e-148 ycgQ S TIGR03943 family
NEBGOCFH_00355 2.4e-156 XK27_03015 S permease
NEBGOCFH_00357 0.0 yhgF K Transcriptional accessory protein
NEBGOCFH_00358 9.9e-42 pspC KT PspC domain
NEBGOCFH_00359 1e-170 hprK F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
NEBGOCFH_00360 4e-147 lgt 2.1.1.199 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NEBGOCFH_00362 5.5e-69 ytxH S General stress protein
NEBGOCFH_00364 2e-177 yegQ O Peptidase U32
NEBGOCFH_00365 6.4e-251 yegQ O Peptidase U32
NEBGOCFH_00366 8.1e-46 S CHY zinc finger
NEBGOCFH_00367 8.4e-88 bioY S biotin synthase
NEBGOCFH_00369 1.1e-33 XK27_12190 S protein conserved in bacteria
NEBGOCFH_00370 7.8e-236 mntH P H( )-stimulated, divalent metal cation uptake system
NEBGOCFH_00371 4e-10
NEBGOCFH_00372 1.3e-66 nudG 3.6.1.55, 3.6.1.65 L Belongs to the Nudix hydrolase family
NEBGOCFH_00373 0.0 L helicase
NEBGOCFH_00374 9.9e-288 lysS 6.1.1.6 J Belongs to the class-II aminoacyl-tRNA synthetase family
NEBGOCFH_00375 1e-163 M LysM domain
NEBGOCFH_00376 7.6e-16
NEBGOCFH_00377 7.5e-174 S hydrolase
NEBGOCFH_00378 2.8e-114 pgm6 5.4.2.11, 5.4.2.12 G Phosphoglycerate mutase
NEBGOCFH_00379 7.9e-82 ybaK S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NEBGOCFH_00380 2e-145 XK27_00880 3.5.1.28 M Glycosyl hydrolase, family 25
NEBGOCFH_00381 2.7e-27 P Hemerythrin HHE cation binding domain protein
NEBGOCFH_00382 6.1e-114 1.14.14.5 C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NEBGOCFH_00383 4.8e-34 MA20_36090 S Protein of unknown function (DUF2974)
NEBGOCFH_00384 0.0 hsdR 3.1.21.3 V Type I restriction enzyme R protein N terminus (HSDR_N)
NEBGOCFH_00385 7.3e-289 hsdM 2.1.1.72 V N-6 DNA Methylase
NEBGOCFH_00386 3.3e-131 3.1.21.3 V type I restriction modification DNA specificity domain
NEBGOCFH_00387 2.5e-44
NEBGOCFH_00388 3.9e-38
NEBGOCFH_00389 4.9e-174 spd F DNA RNA non-specific endonuclease
NEBGOCFH_00390 1.3e-91 lemA S LemA family
NEBGOCFH_00391 2.3e-130 htpX O Belongs to the peptidase M48B family
NEBGOCFH_00392 4.2e-75 S Psort location CytoplasmicMembrane, score
NEBGOCFH_00393 6.2e-56 S Domain of unknown function (DUF4430)
NEBGOCFH_00394 0.0 ppc 4.1.1.31 H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NEBGOCFH_00395 1.2e-183 holA 2.7.7.7 L DNA polymerase III delta subunit
NEBGOCFH_00396 8.5e-113 sodA 1.15.1.1 C radicals which are normally produced within the cells and which are toxic to biological systems
NEBGOCFH_00397 2e-186 3.5.2.6 V D-alanyl-D-alanine carboxypeptidase
NEBGOCFH_00398 4.4e-115 pilD 3.4.23.43 NOU Bacterial Peptidase A24 N-terminal domain
NEBGOCFH_00399 3.2e-92 dps P Belongs to the Dps family
NEBGOCFH_00400 1.1e-80 perR P Belongs to the Fur family
NEBGOCFH_00401 8.4e-28 yqgQ S protein conserved in bacteria
NEBGOCFH_00402 2.2e-179 glk 2.7.1.2 G Glucokinase
NEBGOCFH_00403 0.0 typA T GTP-binding protein TypA
NEBGOCFH_00405 1.6e-252 murD 6.3.2.9 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NEBGOCFH_00406 1e-201 murG 2.4.1.227 GT28 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NEBGOCFH_00407 1.8e-177 divIB D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
NEBGOCFH_00408 8e-252 ftsA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
NEBGOCFH_00409 5.4e-237 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NEBGOCFH_00410 2.3e-122 ylmE S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NEBGOCFH_00411 6.8e-96 sepF D cell septum assembly
NEBGOCFH_00412 2e-34 yggT D integral membrane protein
NEBGOCFH_00413 6.1e-143 ylmH T S4 RNA-binding domain
NEBGOCFH_00414 1.8e-135 divIVA D Cell division protein DivIVA
NEBGOCFH_00415 0.0 ileS 6.1.1.5 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NEBGOCFH_00416 2.5e-09
NEBGOCFH_00417 4.3e-214 mntH P Mn2 and Fe2 transporters of the NRAMP family
NEBGOCFH_00418 2e-45 rpmE2 J 50S ribosomal protein L31
NEBGOCFH_00419 9.8e-177 apbE 2.7.1.180 H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
NEBGOCFH_00420 1e-184 nrnA 3.1.13.3, 3.1.3.7 S domain protein
NEBGOCFH_00421 8.9e-155 gst O Glutathione S-transferase
NEBGOCFH_00422 4.6e-188 add 3.5.4.4 F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NEBGOCFH_00423 4.5e-111 tdk 2.7.1.21 F thymidine kinase
NEBGOCFH_00424 3e-193 prfA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NEBGOCFH_00425 1.8e-153 prmB 2.1.1.297, 2.1.1.298 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
NEBGOCFH_00426 9.7e-109 ywlC 2.7.7.87, 3.1.3.48 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
NEBGOCFH_00427 1.8e-234 glyA 2.1.2.1 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NEBGOCFH_00428 1.2e-177 ndpA S 37-kD nucleoid-associated bacterial protein
NEBGOCFH_00429 6.6e-105 pvaA M lytic transglycosylase activity
NEBGOCFH_00430 0.0 yfiB1 V abc transporter atp-binding protein
NEBGOCFH_00431 0.0 XK27_10035 V abc transporter atp-binding protein
NEBGOCFH_00432 1.7e-09 S D-Ala-teichoic acid biosynthesis protein
NEBGOCFH_00433 1.4e-297 dltA 6.1.1.13 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
NEBGOCFH_00434 3.9e-237 dltB M Membrane protein involved in D-alanine export
NEBGOCFH_00435 1.7e-35 dltC 6.1.1.13 IQ Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
NEBGOCFH_00436 3.6e-230 dltD M Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
NEBGOCFH_00437 7.7e-19 L transposase activity
NEBGOCFH_00438 0.0 3.6.3.8 P cation transport ATPase
NEBGOCFH_00439 0.0 pabB 2.6.1.85, 4.1.3.27, 4.1.3.38 EH component I
NEBGOCFH_00441 0.0 metE 2.1.1.14 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NEBGOCFH_00442 7.3e-166 metF 1.5.1.20 E reductase
NEBGOCFH_00443 0.0 pgm 5.4.2.2, 5.4.2.8 G Phosphoglucomutase
NEBGOCFH_00444 1.7e-94 panT S ECF transporter, substrate-specific component
NEBGOCFH_00445 4.8e-94 coaBC 4.1.1.36, 6.3.2.5 H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NEBGOCFH_00446 1.2e-120 coaB 4.1.1.36, 6.3.2.5 H Phosphopantothenate-cysteine ligase
NEBGOCFH_00447 0.0 fhs 6.3.4.3 F Belongs to the formate--tetrahydrofolate ligase family
NEBGOCFH_00448 6.4e-66 T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
NEBGOCFH_00449 7.9e-37 T PhoQ Sensor
NEBGOCFH_00450 2.2e-43 T PhoQ Sensor
NEBGOCFH_00451 3.6e-88 T PhoQ Sensor
NEBGOCFH_00452 1.7e-28 potC P Binding-protein-dependent transport system inner membrane component
NEBGOCFH_00453 8.9e-206 potD P spermidine putrescine ABC transporter
NEBGOCFH_00454 3.1e-268 clcA P Chloride transporter, ClC family
NEBGOCFH_00455 0.0 prtS 3.4.21.96 O Belongs to the peptidase S8 family
NEBGOCFH_00456 1.9e-21 L Helix-turn-helix domain
NEBGOCFH_00457 2.1e-30 rpsT J rRNA binding
NEBGOCFH_00458 5.5e-172 coaA 2.7.1.33 F Pantothenic acid kinase
NEBGOCFH_00459 5.7e-106 rsmC 2.1.1.172 J Methyltransferase small domain protein
NEBGOCFH_00460 1.2e-57 pdp 2.4.2.2, 2.4.2.4 F Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate
NEBGOCFH_00461 1.3e-97 pdp 2.4.2.2, 2.4.2.4 F Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate
NEBGOCFH_00462 1.4e-22 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NEBGOCFH_00463 1.3e-39 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NEBGOCFH_00464 1.6e-191 tcsA S ABC-type transport system, periplasmic component surface lipoprotein
NEBGOCFH_00465 3.7e-282 xylG 3.6.3.17 S ABC transporter, ATP-binding protein
NEBGOCFH_00466 4.7e-191 yufP S Belongs to the binding-protein-dependent transport system permease family
NEBGOCFH_00467 6.3e-171 yufQ S Belongs to the binding-protein-dependent transport system permease family
NEBGOCFH_00468 8.9e-121 ycbL 3.1.2.6 S COG0491 Zn-dependent hydrolases, including glyoxylases
NEBGOCFH_00469 0.0 dinG 2.7.7.7, 3.6.4.12 L helicase involved in DNA repair and perhaps also replication
NEBGOCFH_00470 3.1e-81 ypmB S Protein conserved in bacteria
NEBGOCFH_00471 1.6e-216 aspB 2.6.1.1, 2.6.1.14 E Aminotransferase
NEBGOCFH_00472 4.2e-261 asnS 6.1.1.22 J Catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
NEBGOCFH_00473 1.5e-07
NEBGOCFH_00474 2.4e-30
NEBGOCFH_00475 3e-13
NEBGOCFH_00476 3e-63 tdcF 3.5.99.10 J endoribonuclease L-PSP
NEBGOCFH_00477 2e-123 queC 6.3.4.20 F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NEBGOCFH_00478 2.2e-81 queD 4.1.2.50, 4.2.3.12 H synthase
NEBGOCFH_00479 3.9e-133 queE 1.97.1.4, 4.3.99.3 H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
NEBGOCFH_00480 2.5e-94 queF 1.7.1.13 S Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily
NEBGOCFH_00481 2.2e-19 D nuclear chromosome segregation
NEBGOCFH_00482 2.8e-137 yejC S cyclic nucleotide-binding protein
NEBGOCFH_00483 1.2e-163 rapZ S Displays ATPase and GTPase activities
NEBGOCFH_00484 3.6e-182 ybhK S Required for morphogenesis under gluconeogenic growth conditions
NEBGOCFH_00485 8.7e-162 whiA K May be required for sporulation
NEBGOCFH_00486 8.4e-168 pepD E Dipeptidase
NEBGOCFH_00487 5.4e-32 cspD K Cold shock protein domain
NEBGOCFH_00488 8e-42 K Cold-Shock Protein
NEBGOCFH_00489 0.0 copB 3.6.3.4 P haloacid dehalogenase-like hydrolase
NEBGOCFH_00491 1.9e-07
NEBGOCFH_00496 0.0 polC 2.7.7.7 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NEBGOCFH_00497 1.2e-235 pepS E COG2309 Leucyl aminopeptidase (aminopeptidase T)
NEBGOCFH_00498 5.5e-36 XK27_02060 S Transglycosylase associated protein
NEBGOCFH_00499 2.6e-55 badR K DNA-binding transcription factor activity
NEBGOCFH_00500 3.5e-97 S reductase
NEBGOCFH_00501 6.9e-89 L Integrase core domain protein
NEBGOCFH_00502 6.4e-41 L transposition
NEBGOCFH_00504 7.9e-76 yocD 3.4.17.13 V carboxypeptidase activity
NEBGOCFH_00505 4.6e-91 yocD 3.4.17.13 V proteins, homologs of microcin C7 resistance protein MccF
NEBGOCFH_00507 1.3e-137 rpsB J Belongs to the universal ribosomal protein uS2 family
NEBGOCFH_00508 1.9e-181 tsf J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NEBGOCFH_00509 1.1e-83 S Putative small multi-drug export protein
NEBGOCFH_00510 6.2e-76 ctsR K Belongs to the CtsR family
NEBGOCFH_00511 0.0 clpC O Belongs to the ClpA ClpB family
NEBGOCFH_00512 3.2e-151 dacA 3.4.16.4 M Belongs to the peptidase S11 family
NEBGOCFH_00513 1.8e-32 dacA 3.4.16.4 M Belongs to the peptidase S11 family
NEBGOCFH_00514 2.9e-190 3.1.21.3 L Subunit R is required for both nuclease and ATPase activities, but not for modification
NEBGOCFH_00515 2.3e-170 mccA 2.5.1.134, 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
NEBGOCFH_00516 9.1e-220 metC 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
NEBGOCFH_00517 1.7e-94 cysE 2.3.1.30 E Bacterial transferase hexapeptide (six repeats)
NEBGOCFH_00518 3.7e-54 hsdS 2.1.1.72, 3.1.21.3 V type I restriction modification DNA specificity domain
NEBGOCFH_00519 1.7e-111 hsdM 2.1.1.72 V type I restriction-modification system
NEBGOCFH_00520 3.7e-157 glcU U Glucose uptake
NEBGOCFH_00521 1.8e-08 4.2.1.53 S Myosin-crossreactive antigen
NEBGOCFH_00522 5.9e-79 hsdM 2.1.1.72 V HsdM N-terminal domain
NEBGOCFH_00523 1.6e-77 XK27_10720 D peptidase activity
NEBGOCFH_00524 4.7e-293 adcA P Belongs to the bacterial solute-binding protein 9 family
NEBGOCFH_00525 1.7e-08
NEBGOCFH_00526 7.5e-217 L Transposase
NEBGOCFH_00527 1.2e-24 XK27_06780 V FtsX-like permease family
NEBGOCFH_00528 3.8e-55 XK27_06780 V FtsX-like permease family
NEBGOCFH_00529 5.2e-45 XK27_06780 V FtsX-like permease family
NEBGOCFH_00530 5.5e-112 XK27_06780 V FtsX-like permease family
NEBGOCFH_00532 2.6e-180 cpsE M Bacterial sugar transferase
NEBGOCFH_00533 9.8e-82 cpsF M Oligosaccharide biosynthesis protein Alg14 like
NEBGOCFH_00534 3.7e-40 pssE S Glycosyltransferase family 28 C-terminal domain
NEBGOCFH_00535 2.6e-08 pssE S Glycosyltransferase family 28 C-terminal domain
NEBGOCFH_00536 4.7e-15 S Polysaccharide pyruvyl transferase
NEBGOCFH_00537 2.4e-102 S Polysaccharide biosynthesis C-terminal domain
NEBGOCFH_00538 2.1e-205 GT4 M Glycosyltransferase, group 1 family protein
NEBGOCFH_00539 3.5e-172 yeiH S Membrane
NEBGOCFH_00540 1.6e-118 mur1 NU muramidase
NEBGOCFH_00541 4.2e-20 L transposase activity
NEBGOCFH_00542 4.5e-166 cpsY K Transcriptional regulator
NEBGOCFH_00543 0.0 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
NEBGOCFH_00544 1.2e-57 phnA P Alkylphosphonate utilization operon protein PhnA
NEBGOCFH_00545 5.3e-105 artQ P ABC transporter (Permease
NEBGOCFH_00546 1.5e-112 glnQ 3.6.3.21 E abc transporter atp-binding protein
NEBGOCFH_00547 1.2e-157 aatB ET ABC transporter substrate-binding protein
NEBGOCFH_00548 7.1e-147 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NEBGOCFH_00549 1.7e-57 adhP 1.1.1.1 C alcohol dehydrogenase
NEBGOCFH_00550 1.3e-106 adhP 1.1.1.1 C alcohol dehydrogenase
NEBGOCFH_00551 2.8e-49 sthIM 2.1.1.72 L Adenine specific DNA methylase Mod
NEBGOCFH_00552 3.9e-303 guaA 2.3.1.128, 6.3.5.2 F Catalyzes the synthesis of GMP from XMP
NEBGOCFH_00553 4.5e-126 gntR1 K transcriptional
NEBGOCFH_00554 1.1e-53 ylxM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
NEBGOCFH_00555 1.3e-269 ffh 3.6.5.4 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NEBGOCFH_00556 4.1e-87 niaX
NEBGOCFH_00557 8.6e-90 niaR S small molecule binding protein (contains 3H domain)
NEBGOCFH_00558 1.8e-127 K DNA-binding helix-turn-helix protein
NEBGOCFH_00559 1.1e-158 ylqF S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NEBGOCFH_00560 1.4e-136 rnhB 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NEBGOCFH_00561 8.2e-168 GK ROK family
NEBGOCFH_00562 8.3e-159 dprA LU DNA protecting protein DprA
NEBGOCFH_00563 0.0 topA 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NEBGOCFH_00564 6.9e-150 S TraX protein
NEBGOCFH_00565 2.2e-122 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
NEBGOCFH_00566 2.8e-252 T PhoQ Sensor
NEBGOCFH_00567 6.6e-259 trmFO 2.1.1.74 J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
NEBGOCFH_00568 7.2e-152 XK27_05470 E Methionine synthase
NEBGOCFH_00569 7.5e-21 XK27_05470 E Methionine synthase
NEBGOCFH_00570 1.7e-75 ndk 2.7.4.6 F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
NEBGOCFH_00571 1e-47 pspE P Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NEBGOCFH_00572 2.2e-49 IQ Acetoin reductase
NEBGOCFH_00573 3.9e-19 IQ Acetoin reductase
NEBGOCFH_00574 0.0 lepA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
NEBGOCFH_00575 6.7e-156 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
NEBGOCFH_00578 4.5e-125 pqqE C radical SAM domain protein
NEBGOCFH_00579 3.9e-136 speB 3.5.3.11 E hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
NEBGOCFH_00580 6.6e-61 EGP Major facilitator Superfamily
NEBGOCFH_00581 0.0 alsS 2.2.1.6 EH Belongs to the TPP enzyme family
NEBGOCFH_00582 3e-133 budA 4.1.1.5 H Belongs to the alpha-acetolactate decarboxylase family
NEBGOCFH_00583 6.3e-111 L Transposase
NEBGOCFH_00584 4e-72 L Transposase
NEBGOCFH_00585 6.4e-104 V ABC transporter (Permease
NEBGOCFH_00586 2.8e-115 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
NEBGOCFH_00587 1.6e-10
NEBGOCFH_00588 9e-98 K Transcriptional regulator, TetR family
NEBGOCFH_00589 1.8e-159 czcD P cation diffusion facilitator family transporter
NEBGOCFH_00590 2.7e-210 hemH 4.99.1.1, 4.99.1.9 H Catalyzes the ferrous insertion into protoporphyrin IX
NEBGOCFH_00591 6.2e-196 adhB 1.1.1.1, 1.1.1.14 E Dehydrogenase
NEBGOCFH_00592 6e-08 S Hydrolases of the alpha beta superfamily
NEBGOCFH_00593 7.9e-17 S Alpha/beta hydrolase of unknown function (DUF915)
NEBGOCFH_00594 4.5e-79 S Alpha/beta hydrolase of unknown function (DUF915)
NEBGOCFH_00597 1.2e-143 2.4.2.3 F Phosphorylase superfamily
NEBGOCFH_00598 9.2e-118 gph 3.1.3.18 S HAD hydrolase, family IA, variant 1
NEBGOCFH_00599 9.4e-15 yclQ P ABC-type enterochelin transport system, periplasmic component
NEBGOCFH_00600 3.3e-19 yclQ P ABC-type enterochelin transport system, periplasmic component
NEBGOCFH_00601 8.6e-15 dinF V Mate efflux family protein
NEBGOCFH_00602 9.2e-311 FbpA K RNA-binding protein homologous to eukaryotic snRNP
NEBGOCFH_00603 1.1e-87 S TraX protein
NEBGOCFH_00604 5.9e-97 thiJ 2.7.11.1, 3.5.1.124 S DJ-1 family
NEBGOCFH_00605 1.8e-147 pyrK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )
NEBGOCFH_00606 9.3e-175 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
NEBGOCFH_00607 2.3e-187 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
NEBGOCFH_00608 9.8e-55 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
NEBGOCFH_00609 9.9e-132 cas6 S Pfam:DUF2276
NEBGOCFH_00610 0.0 csm1 S CRISPR-associated protein Csm1 family
NEBGOCFH_00611 9.9e-38 csm2 L Csm2 Type III-A
NEBGOCFH_00612 1.6e-117 csm3 L RAMP superfamily
NEBGOCFH_00613 5.2e-167 csm4 L CRISPR-associated RAMP protein, Csm4 family
NEBGOCFH_00614 2.9e-204 csm5 L CRISPR-associated RAMP protein, Csm5 family
NEBGOCFH_00615 3.4e-60 csm6 S Psort location Cytoplasmic, score
NEBGOCFH_00616 2.8e-38 csm6 S Psort location Cytoplasmic, score
NEBGOCFH_00617 5.6e-146 csm6 S Psort location Cytoplasmic, score
NEBGOCFH_00618 9.1e-127 pyrF 4.1.1.23 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
NEBGOCFH_00619 7.5e-112 pyrE 2.4.2.10, 4.1.1.23 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NEBGOCFH_00620 7.9e-266 dtpT E transporter
NEBGOCFH_00621 1e-103 nylA 3.5.1.4 J Belongs to the amidase family
NEBGOCFH_00622 8.8e-134 yckB ET Belongs to the bacterial solute-binding protein 3 family
NEBGOCFH_00623 1.8e-67 yecS P ABC transporter (Permease
NEBGOCFH_00625 8.1e-114 sasH 3.1.3.5, 3.6.1.45 F Belongs to the 5'-nucleotidase family
NEBGOCFH_00626 9.8e-35 3.1.3.6, 3.1.4.16 F nucleotide catabolic process
NEBGOCFH_00627 1.4e-104 yfiF3 K sequence-specific DNA binding
NEBGOCFH_00628 1.6e-247 mnmE S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NEBGOCFH_00629 1.8e-240 agcS E (Alanine) symporter
NEBGOCFH_00630 0.0 pcrA 3.6.4.12 L ATP-dependent DNA helicase
NEBGOCFH_00631 4.6e-241 metY 2.5.1.49 E o-acetylhomoserine
NEBGOCFH_00632 1.8e-31 S haloacid dehalogenase-like hydrolase
NEBGOCFH_00633 7.8e-61 S haloacid dehalogenase-like hydrolase
NEBGOCFH_00634 1.3e-87 tpx 1.11.1.15 O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
NEBGOCFH_00635 1.1e-110 hsdS2 2.1.1.72 V Type I restriction modification DNA specificity domain
NEBGOCFH_00636 1.7e-96 XK27_04775 S hemerythrin HHE cation binding domain
NEBGOCFH_00637 2.6e-49 XK27_04775 S hemerythrin HHE cation binding domain
NEBGOCFH_00638 4.9e-151 truB 5.4.99.25 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NEBGOCFH_00639 5.3e-175 ribF 2.7.1.26, 2.7.7.2 H Belongs to the ribF family
NEBGOCFH_00640 1.4e-71 spxA 1.20.4.1 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
NEBGOCFH_00641 1.9e-43 yktA S Belongs to the UPF0223 family
NEBGOCFH_00642 5e-142 suhB 3.1.3.25 G Belongs to the inositol monophosphatase superfamily
NEBGOCFH_00643 3e-256 rsmF 2.1.1.176, 2.1.1.178 J NOL1 NOP2 sun family protein
NEBGOCFH_00644 3.3e-158 pstS P phosphate
NEBGOCFH_00645 2.5e-156 pstC P probably responsible for the translocation of the substrate across the membrane
NEBGOCFH_00646 1.2e-155 pstA P phosphate transport system permease
NEBGOCFH_00647 5.2e-150 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
NEBGOCFH_00648 1.7e-139 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
NEBGOCFH_00649 2.4e-113 phoU P Plays a role in the regulation of phosphate uptake
NEBGOCFH_00650 0.0 pepN 3.4.11.2 E aminopeptidase
NEBGOCFH_00651 7e-195 xerS D Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division
NEBGOCFH_00652 8.5e-187 lplA 6.3.1.20 H Lipoate-protein ligase
NEBGOCFH_00653 1.5e-17
NEBGOCFH_00654 3.7e-09
NEBGOCFH_00655 0.0 glgP 2.4.1.1 GT35 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
NEBGOCFH_00656 3.4e-304 malQ 2.4.1.25 GH77 G 4-alpha-glucanotransferase
NEBGOCFH_00657 2.3e-23 L Transposase
NEBGOCFH_00658 4.6e-25 tatA U protein secretion
NEBGOCFH_00659 5.8e-121 tatC U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NEBGOCFH_00660 3.9e-301 ywbL P COG0672 High-affinity Fe2 Pb2 permease
NEBGOCFH_00661 5.6e-233 ycdB P peroxidase
NEBGOCFH_00662 2.3e-151 ycdO P periplasmic lipoprotein involved in iron transport
NEBGOCFH_00663 3e-34 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
NEBGOCFH_00664 3.7e-85 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
NEBGOCFH_00665 1.7e-60 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
NEBGOCFH_00666 1.5e-65 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
NEBGOCFH_00667 4e-134 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
NEBGOCFH_00668 1.9e-186 3.5.1.28 M GBS Bsp-like repeat
NEBGOCFH_00669 2.7e-67 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
NEBGOCFH_00670 9.9e-12 3.5.1.28 NU amidase activity
NEBGOCFH_00671 0.0 lpdA 1.8.1.4 C Dehydrogenase
NEBGOCFH_00672 1e-198 acoC 2.3.1.12 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
NEBGOCFH_00673 3.7e-182 acoB 1.2.4.1, 1.2.4.4 C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
NEBGOCFH_00674 6e-185 acoA 1.2.4.1, 1.2.4.4 C Dehydrogenase E1 component
NEBGOCFH_00675 5e-38 P membrane protein (DUF2207)
NEBGOCFH_00676 2.8e-65 S the current gene model (or a revised gene model) may contain a frame shift
NEBGOCFH_00677 8.2e-235 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
NEBGOCFH_00678 2.9e-127 ung 3.2.2.27 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NEBGOCFH_00679 8.6e-218 yeaB K Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NEBGOCFH_00680 1.9e-158 rssA S Phospholipase, patatin family
NEBGOCFH_00681 2.8e-70 estA E GDSL-like protein
NEBGOCFH_00682 3.4e-29 estA E Lysophospholipase L1 and related esterases
NEBGOCFH_00683 5.9e-291 S unusual protein kinase
NEBGOCFH_00684 4.9e-39 S granule-associated protein
NEBGOCFH_00685 7.1e-36 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
NEBGOCFH_00686 7.1e-139 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
NEBGOCFH_00687 2e-18 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
NEBGOCFH_00688 5e-199 S hmm pf01594
NEBGOCFH_00689 1.6e-44 G alpha-ribazole phosphatase activity
NEBGOCFH_00690 1e-86 supH 3.1.3.102, 3.1.3.104 S Sucrose-6F-phosphate phosphohydrolase
NEBGOCFH_00691 2.9e-94 V VanZ like family
NEBGOCFH_00692 8.8e-46 L Transposase
NEBGOCFH_00693 3.6e-157 L Transposase
NEBGOCFH_00694 7.1e-13 traI 5.99.1.2 L This gene contains a nucleotide ambiguity which may be the result of a sequencing error
NEBGOCFH_00695 7.8e-242 cps1C S Polysaccharide biosynthesis protein
NEBGOCFH_00696 7.1e-08 tnp L DDE domain
NEBGOCFH_00697 2.5e-17 tnp L DDE domain
NEBGOCFH_00698 2.1e-92 2.7.8.12 GT2 S Glycosyltransferase like family 2
NEBGOCFH_00699 4.7e-140 L Integrase core domain
NEBGOCFH_00700 7.8e-38 tnp L DDE domain
NEBGOCFH_00701 4.2e-20
NEBGOCFH_00702 1.5e-40 M Glycosyltransferase like family 2
NEBGOCFH_00703 9.5e-15 M O-antigen ligase
NEBGOCFH_00704 7.6e-73 MA20_17390 GT4 M Glycosyl transferases group 1
NEBGOCFH_00705 7.7e-56 M Glycosyl transferases group 1
NEBGOCFH_00706 4.3e-11 waaB GT4 M Glycosyl transferases group 1
NEBGOCFH_00708 7.7e-46 pssE S Glycosyltransferase family 28 C-terminal domain
NEBGOCFH_00709 3.2e-64 cpsF M Oligosaccharide biosynthesis protein Alg14 like
NEBGOCFH_00710 1.6e-23 rgpAc GT4 M group 1 family protein
NEBGOCFH_00711 9.7e-239 cpsE M Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
NEBGOCFH_00712 2.9e-115 cpsD D COG0489 ATPases involved in chromosome partitioning
NEBGOCFH_00713 5e-101 cps4C M biosynthesis protein
NEBGOCFH_00714 3.9e-136 cpsB 3.1.3.48 GM Capsular polysaccharide biosynthesis protein
NEBGOCFH_00715 5.3e-254 cps4A K Cell envelope-like function transcriptional attenuator common domain protein
NEBGOCFH_00716 9e-130 deoD 2.4.2.1, 2.4.2.28 F purine nucleoside phosphorylase
NEBGOCFH_00717 1.5e-119 yfeJ 6.3.5.2 F glutamine amidotransferase
NEBGOCFH_00718 7.3e-41 clcA_2 P chloride
NEBGOCFH_00719 3.8e-42 clcA_2 P chloride channel
NEBGOCFH_00720 5.8e-149 punA 2.4.2.1 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NEBGOCFH_00721 1.3e-41 S Protein of unknown function (DUF1697)
NEBGOCFH_00722 2.9e-237 deoB 5.4.2.7 G Phosphotransfer between the C1 and C5 carbon atoms of pentose
NEBGOCFH_00723 5e-122 rpiA 2.7.1.12, 2.7.1.15, 5.3.1.6 G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
NEBGOCFH_00725 4e-21 V Glucan-binding protein C
NEBGOCFH_00726 1e-110 ung2 3.2.2.27 L Uracil-DNA glycosylase
NEBGOCFH_00727 1.3e-273 pepV 3.5.1.18 E Dipeptidase
NEBGOCFH_00728 6.4e-27 dmpI 5.3.2.6 G Belongs to the 4-oxalocrotonate tautomerase family
NEBGOCFH_00729 8.6e-23 XK27_03610 K Gnat family
NEBGOCFH_00730 1.6e-24 L Transposase
NEBGOCFH_00731 5.8e-42 L Transposase
NEBGOCFH_00732 1.5e-56 rplT J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NEBGOCFH_00733 2.1e-28 rpmI J Belongs to the bacterial ribosomal protein bL35 family
NEBGOCFH_00734 3.5e-86 infC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NEBGOCFH_00735 2.5e-121 cmk 1.17.7.4, 2.5.1.19, 2.7.1.26, 2.7.4.25, 2.7.7.2, 6.3.2.1 F Belongs to the cytidylate kinase family. Type 1 subfamily
NEBGOCFH_00736 2.8e-18 M LysM domain
NEBGOCFH_00737 2.9e-90 ebsA S Family of unknown function (DUF5322)
NEBGOCFH_00738 1.1e-228 pepT 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
NEBGOCFH_00739 3e-96 lepB 3.4.21.89 U Belongs to the peptidase S26 family
NEBGOCFH_00740 2.4e-223 G COG0457 FOG TPR repeat
NEBGOCFH_00741 6.2e-176 yubA S permease
NEBGOCFH_00742 4.6e-93 mutX 3.6.1.55 F NTP pyrophosphohydrolases including oxidative damage repair enzymes
NEBGOCFH_00743 3.6e-163 ftsX D Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation
NEBGOCFH_00744 2.5e-124 ftsE D cell division ATP-binding protein FtsE
NEBGOCFH_00745 7.4e-183 prfB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NEBGOCFH_00746 1.2e-202 queG 1.17.99.6 C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NEBGOCFH_00747 1.9e-180 yjjH S Calcineurin-like phosphoesterase
NEBGOCFH_00748 5.2e-136 nfrA 1.5.1.38, 1.5.1.39 C nitroreductase
NEBGOCFH_00749 0.0 pacL 3.6.3.8 P cation transport ATPase
NEBGOCFH_00750 2.6e-67 ywiB S Domain of unknown function (DUF1934)
NEBGOCFH_00751 6.3e-51 XK27_00115 2.3.1.128 K acetyltransferase
NEBGOCFH_00752 9.2e-147 yidA S hydrolases of the HAD superfamily
NEBGOCFH_00753 9e-231 murM 2.3.2.10, 2.3.2.16 V protein involved in methicillin resistance
NEBGOCFH_00754 1e-153 vicX 3.1.26.11 S Metal-dependent hydrolases of the beta-lactamase superfamily I
NEBGOCFH_00755 1.4e-245 vicK 2.7.13.3 T Histidine kinase
NEBGOCFH_00756 2.9e-128 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
NEBGOCFH_00757 2.1e-140 glnQ 3.6.3.21 E abc transporter atp-binding protein
NEBGOCFH_00758 4.5e-149 peb1A ET ABC-type amino acid transport signal transduction systems, periplasmic component domain
NEBGOCFH_00759 7.7e-118 gltJ P ABC transporter (Permease
NEBGOCFH_00760 4.2e-110 tcyB_2 P ABC transporter (permease)
NEBGOCFH_00761 2.4e-124 endA F DNA RNA non-specific endonuclease
NEBGOCFH_00762 1.2e-25 epuA S DNA-directed RNA polymerase subunit beta
NEBGOCFH_00763 1.1e-231 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NEBGOCFH_00765 2.7e-196 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
NEBGOCFH_00766 5.9e-26 G Domain of unknown function (DUF4832)
NEBGOCFH_00767 2.1e-203 metK 2.5.1.6 H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NEBGOCFH_00768 1.2e-174 birA 6.3.4.15 HK Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
NEBGOCFH_00769 4.1e-295 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NEBGOCFH_00770 1.6e-88 ytsP 1.8.4.14 T GAF domain-containing protein
NEBGOCFH_00771 4.2e-164 miaA 2.5.1.75 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NEBGOCFH_00772 7.2e-20 WQ51_02665 S Protein of unknown function (DUF3042)
NEBGOCFH_00773 7.7e-35
NEBGOCFH_00776 5.4e-203 S Phage integrase family
NEBGOCFH_00778 8.5e-57 rplS J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
NEBGOCFH_00779 6.1e-219 XK27_05110 P chloride
NEBGOCFH_00780 8.7e-41 pheA 1.3.1.12, 2.3.1.79, 4.2.1.51, 5.4.99.5 E Chorismate mutase
NEBGOCFH_00781 1.3e-282 clcA P Chloride transporter, ClC family
NEBGOCFH_00782 2.3e-75 fld C Flavodoxin
NEBGOCFH_00783 3.3e-14 XK27_08880
NEBGOCFH_00784 4.7e-126 XK27_08875 O Zinc-dependent metalloprotease
NEBGOCFH_00785 1e-150 estA CE1 S Putative esterase
NEBGOCFH_00786 2.3e-309 rnjB S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NEBGOCFH_00787 4.4e-135 XK27_08845 S abc transporter atp-binding protein
NEBGOCFH_00788 2e-147 XK27_08840 S Belongs to the binding-protein-dependent transport system permease family
NEBGOCFH_00789 9.5e-178 XK27_08835 S ABC transporter substrate binding protein
NEBGOCFH_00791 8.1e-42 Q the current gene model (or a revised gene model) may contain a frame shift
NEBGOCFH_00792 2.7e-26 Q the current gene model (or a revised gene model) may contain a frame shift
NEBGOCFH_00795 6.7e-276 pyk 2.7.1.40, 2.7.7.4 G Belongs to the pyruvate kinase family
NEBGOCFH_00796 1.2e-188 pfkA 2.7.1.11 F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
NEBGOCFH_00797 0.0 dnaE 2.7.7.7 L DNA polymerase
NEBGOCFH_00798 1.4e-152 sua5 2.7.7.87 J Belongs to the SUA5 family
NEBGOCFH_00799 3.1e-112 leuD 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NEBGOCFH_00800 4.4e-274 leuC 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NEBGOCFH_00801 2.5e-43 ysdA L Membrane
NEBGOCFH_00802 7.3e-189 leuB 1.1.1.85 CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
NEBGOCFH_00803 5.9e-291 leuA 2.3.3.13 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NEBGOCFH_00804 4.6e-131 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NEBGOCFH_00805 3.6e-179 pyrD 1.3.1.14, 1.3.98.1 F Catalyzes the conversion of dihydroorotate to orotate
NEBGOCFH_00807 2.8e-39 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
NEBGOCFH_00808 1.7e-83 ypmS S Protein conserved in bacteria
NEBGOCFH_00809 6e-144 ypmR E lipolytic protein G-D-S-L family
NEBGOCFH_00810 1e-148 DegV S DegV family
NEBGOCFH_00811 1.7e-304 recN L May be involved in recombinational repair of damaged DNA
NEBGOCFH_00812 3.7e-73 argR K Regulates arginine biosynthesis genes
NEBGOCFH_00813 5e-159 rrmJ 2.1.1.226, 2.1.1.227 J Ribosomal RNA large subunit methyltransferase J
NEBGOCFH_00814 6.6e-159 ispA 2.5.1.1, 2.5.1.10, 2.5.1.29, 2.5.1.90 H Belongs to the FPP GGPP synthase family
NEBGOCFH_00815 3.5e-29 xseB 3.1.11.6 L exodeoxyribonuclease VII activity
NEBGOCFH_00816 1.2e-247 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
NEBGOCFH_00819 3.4e-120 nth 4.2.99.18 L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NEBGOCFH_00820 2.9e-125 dnaD
NEBGOCFH_00821 9.3e-183 metA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NEBGOCFH_00822 2e-94 apt 2.4.2.22, 2.4.2.7 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NEBGOCFH_00823 0.0 recJ L Single-strand DNA-specific exonuclease, C terminal domain
NEBGOCFH_00824 6.7e-139 XK27_05435 1.1.1.100 S Belongs to the short-chain dehydrogenases reductases (SDR) family
NEBGOCFH_00825 2.7e-174 rnz 3.1.26.11 S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
NEBGOCFH_00826 4.2e-118 galT 2.7.7.12 G UDPglucose--hexose-1-phosphate uridylyltransferase
NEBGOCFH_00827 1.4e-223 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NEBGOCFH_00828 5.6e-240 rodA D Belongs to the SEDS family
NEBGOCFH_00829 1.8e-50 hisE 3.5.4.19, 3.6.1.31, 5.3.1.16 E Phosphoribosyl-ATP
NEBGOCFH_00830 5.5e-61 hisI 3.5.4.19, 3.5.4.25, 3.6.1.31, 5.3.1.16 E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NEBGOCFH_00831 8.9e-136 hisF 3.5.4.19, 3.6.1.31 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
NEBGOCFH_00832 1.9e-127 hisA 5.3.1.16 E 1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NEBGOCFH_00833 4.4e-109 hisH E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NEBGOCFH_00834 1.5e-106 hisB 1.1.1.23, 2.6.1.9, 3.1.3.15, 4.2.1.19 E imidazoleglycerol-phosphate dehydratase
NEBGOCFH_00835 3.5e-233 hisD 1.1.1.23, 1.1.1.308 E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NEBGOCFH_00836 2.3e-116 hisG 2.4.2.17 E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
NEBGOCFH_00837 5.7e-183 hisZ 2.4.2.17, 6.1.1.21 E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
NEBGOCFH_00838 2.1e-196 hisC 2.6.1.9 E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NEBGOCFH_00840 2.9e-57 L Integrase core domain protein
NEBGOCFH_00841 8e-37 L transposase activity
NEBGOCFH_00842 7.4e-21 XK27_08085
NEBGOCFH_00843 5.6e-92 XK27_08080 3.1.1.53 G Exopolysaccharide biosynthesis protein
NEBGOCFH_00844 2.3e-09 XK27_08080 3.1.1.53 G Exopolysaccharide biosynthesis protein
NEBGOCFH_00845 2e-140 hisK 3.1.3.15 E Histidinol phosphatase and related hydrolases of the PHP family
NEBGOCFH_00846 1.1e-121 ylfI S tigr01906
NEBGOCFH_00847 5.9e-143 nagD 2.7.1.25, 3.1.3.41 G Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
NEBGOCFH_00848 5.7e-143 fat 3.1.2.21 I Acyl-ACP thioesterase
NEBGOCFH_00849 1.5e-216 hemN H Involved in the biosynthesis of porphyrin-containing compound
NEBGOCFH_00852 1.9e-205 rfbB 4.2.1.46 M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
NEBGOCFH_00853 8.3e-113 rmlC 1.1.1.133, 5.1.3.13 M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
NEBGOCFH_00854 1.9e-161 rfbA 2.7.7.24 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NEBGOCFH_00855 1.6e-207 yurR 1.4.5.1 E oxidoreductase
NEBGOCFH_00856 6.4e-29 zupT P transporter
NEBGOCFH_00857 2.3e-14 zupT P Mediates zinc uptake. May also transport other divalent cations
NEBGOCFH_00858 9.6e-149 yqfO 3.5.4.16 S Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NEBGOCFH_00859 2.7e-123 trmK 2.1.1.217 S SAM-dependent methyltransferase
NEBGOCFH_00860 1.7e-70 gtrA S GtrA-like protein
NEBGOCFH_00861 1.5e-250 glmM 5.4.2.10 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NEBGOCFH_00862 6e-169 ybbR S Protein conserved in bacteria
NEBGOCFH_00863 5.6e-124 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NEBGOCFH_00864 2.2e-254 murD 3.4.21.10, 6.3.2.13, 6.3.2.9 M Mur ligase, middle domain protein
NEBGOCFH_00865 8.7e-150 cobQ S glutamine amidotransferase
NEBGOCFH_00866 0.0 mprF 2.3.2.3 J Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NEBGOCFH_00867 2.2e-131 pip 1.11.1.10 S Alpha beta hydrolase
NEBGOCFH_00868 0.0 uup S abc transporter atp-binding protein
NEBGOCFH_00869 6.2e-114 udk 2.7.1.48 F Cytidine monophosphokinase
NEBGOCFH_00870 3.5e-178 yfmL 3.6.4.13 L DEAD DEAH box helicase
NEBGOCFH_00871 2.1e-28 6.3.2.2, 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
NEBGOCFH_00872 3.3e-264 gapN 1.2.1.9 C Belongs to the aldehyde dehydrogenase family
NEBGOCFH_00873 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NEBGOCFH_00874 7.9e-39 ptsH G phosphocarrier protein Hpr
NEBGOCFH_00875 2e-222 icd 1.1.1.42 C Isocitrate dehydrogenase
NEBGOCFH_00876 5.1e-212 citZ 2.3.3.1 C Belongs to the citrate synthase family
NEBGOCFH_00877 0.0 acnA 4.2.1.3 C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NEBGOCFH_00878 8.5e-34 nrdH O Glutaredoxin
NEBGOCFH_00879 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NEBGOCFH_00880 1.7e-184 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NEBGOCFH_00882 1.9e-71 L Transposase (IS116 IS110 IS902 family)
NEBGOCFH_00883 3.6e-61 L Transposase (IS116 IS110 IS902 family)
NEBGOCFH_00884 1.8e-165 ypuA S secreted protein
NEBGOCFH_00885 3.9e-53 yaeR E COG0346 LactoylglutaTHIone lyase and related lyases
NEBGOCFH_00886 1.7e-134 srtA 3.4.22.70 M Sortase (surface protein transpeptidase)
NEBGOCFH_00887 0.0 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NEBGOCFH_00888 1.1e-181 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
NEBGOCFH_00889 2.1e-230 dacA 3.4.16.4 M Belongs to the peptidase S11 family
NEBGOCFH_00890 0.0 pnp 2.7.7.8 J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
NEBGOCFH_00891 6.9e-144 S SseB protein N-terminal domain
NEBGOCFH_00892 1.1e-112 cysE 2.3.1.30 E serine acetyltransferase
NEBGOCFH_00893 1.7e-259 cysS 6.1.1.16, 6.3.1.13 J Belongs to the class-I aminoacyl-tRNA synthetase family
NEBGOCFH_00894 4.2e-68 mrnC J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
NEBGOCFH_00897 5.7e-135 trmH 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NEBGOCFH_00898 3.5e-91 yacP S RNA-binding protein containing a PIN domain
NEBGOCFH_00899 3.4e-155 degV S DegV family
NEBGOCFH_00900 1.8e-31 K helix-turn-helix
NEBGOCFH_00901 1.6e-182 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NEBGOCFH_00902 2e-79 rplM J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NEBGOCFH_00903 9.5e-65 rpsI J Belongs to the universal ribosomal protein uS9 family
NEBGOCFH_00904 8.5e-112 int L Belongs to the 'phage' integrase family
NEBGOCFH_00905 4.5e-83 int L Belongs to the 'phage' integrase family
NEBGOCFH_00906 8.7e-41 S Helix-turn-helix domain
NEBGOCFH_00908 6.4e-55
NEBGOCFH_00909 3.4e-258 noxE P NADH oxidase
NEBGOCFH_00910 1.9e-294 yfmM S abc transporter atp-binding protein
NEBGOCFH_00911 3.3e-82 XK27_01265 S ECF-type riboflavin transporter, S component
NEBGOCFH_00912 8.7e-85 pdxK 2.7.1.35 H Belongs to the pyridoxine kinase family
NEBGOCFH_00913 5.5e-42 pdxK 2.7.1.35 H Belongs to the pyridoxine kinase family
NEBGOCFH_00914 2e-86 S ECF-type riboflavin transporter, S component
NEBGOCFH_00916 7.7e-241 XK27_08130 K Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
NEBGOCFH_00917 2e-55 nrdD_1 1.1.98.6, 1.17.4.1 F Ribonucleoside-triphosphate reductase
NEBGOCFH_00919 0.0 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
NEBGOCFH_00920 9.9e-94 paiA 2.3.1.57 K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
NEBGOCFH_00921 1.1e-197 pheS 6.1.1.20 J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NEBGOCFH_00922 0.0 smc D Required for chromosome condensation and partitioning
NEBGOCFH_00923 8.4e-125 rnc 3.1.26.3 J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
NEBGOCFH_00924 6.6e-173 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NEBGOCFH_00925 7.3e-200 asd 1.2.1.11 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NEBGOCFH_00926 7.3e-82 alkD L Dna alkylation repair
NEBGOCFH_00927 2.8e-93 pat 2.3.1.183 M acetyltransferase
NEBGOCFH_00928 3e-13
NEBGOCFH_00929 9e-278 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NEBGOCFH_00930 0.0 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
NEBGOCFH_00931 3.1e-127 yjjG 3.1.3.102, 3.1.3.104, 3.1.3.5, 3.8.1.2 E hydrolase
NEBGOCFH_00932 1.8e-13 bioY S biotin synthase
NEBGOCFH_00933 9.8e-88 proW P Binding-protein-dependent transport system inner membrane component
NEBGOCFH_00934 1.5e-138 proV E abc transporter atp-binding protein
NEBGOCFH_00935 2e-169 proX M ABC transporter, substrate-binding protein, QAT family
NEBGOCFH_00936 8.7e-111 proWZ P ABC transporter (Permease
NEBGOCFH_00937 2.6e-280 hutH 4.3.1.3 E Histidine ammonia-lyase
NEBGOCFH_00938 1.6e-205 S Protein of unknown function (DUF917)
NEBGOCFH_00939 1.3e-309 hutU 4.2.1.49 E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NEBGOCFH_00940 1.6e-59 sdaAB 4.3.1.17 E L-serine dehydratase
NEBGOCFH_00941 4.4e-101 desR K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
NEBGOCFH_00942 1.5e-192 desK 2.7.13.3 T Histidine kinase
NEBGOCFH_00943 2.6e-132 yvfS V ABC-2 type transporter
NEBGOCFH_00944 1.6e-157 XK27_09825 V abc transporter atp-binding protein
NEBGOCFH_00948 3.3e-212 EGP Major facilitator Superfamily
NEBGOCFH_00949 0.0 2.7.7.73, 2.7.7.80 E metalloendopeptidase activity
NEBGOCFH_00950 3.5e-152 mutR K Transcriptional activator, Rgg GadR MutR family
NEBGOCFH_00951 4.6e-42 3.6.1.55 F NUDIX domain
NEBGOCFH_00953 2.4e-121 S An automated process has identified a potential problem with this gene model
NEBGOCFH_00954 6.1e-26 XK27_09825 V 'abc transporter, ATP-binding protein
NEBGOCFH_00955 3.1e-15 liaI KT membrane
NEBGOCFH_00956 3.8e-29 liaI KT membrane
NEBGOCFH_00957 4.7e-93 XK27_05000 S Fe-S-cluster oxidoreductase
NEBGOCFH_00958 0.0 V ABC transporter (permease)
NEBGOCFH_00959 1.9e-133 macB2 V ABC transporter, ATP-binding protein
NEBGOCFH_00960 6.2e-166 T Histidine kinase
NEBGOCFH_00961 4.6e-123 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
NEBGOCFH_00962 3.2e-78 xpt 2.4.2.22, 2.4.2.7 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
NEBGOCFH_00964 1.5e-69 pbuX F xanthine permease
NEBGOCFH_00965 9.2e-119 pbuX F xanthine permease
NEBGOCFH_00966 4.5e-247 norM V Multidrug efflux pump
NEBGOCFH_00967 1.3e-187 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NEBGOCFH_00968 1.7e-235 brnQ E Component of the transport system for branched-chain amino acids
NEBGOCFH_00969 9.4e-65 manA 5.3.1.8 G mannose-6-phosphate isomerase
NEBGOCFH_00970 8.2e-57 manA 5.3.1.8 G mannose-6-phosphate isomerase
NEBGOCFH_00971 9.6e-26 csbD K CsbD-like
NEBGOCFH_00973 6.2e-228 yfnA E amino acid
NEBGOCFH_00974 7.4e-109 XK27_02070 S nitroreductase
NEBGOCFH_00975 9.5e-150 1.13.11.2 S glyoxalase
NEBGOCFH_00976 5.6e-77 ywnA K Transcriptional regulator
NEBGOCFH_00977 9.5e-158 E Alpha/beta hydrolase of unknown function (DUF915)
NEBGOCFH_00978 2e-228 pts13C G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
NEBGOCFH_00979 1.4e-110 drgA C Nitroreductase
NEBGOCFH_00980 2.3e-108 yoaK S Protein of unknown function (DUF1275)
NEBGOCFH_00981 6.8e-161 yvgN C reductase
NEBGOCFH_00982 1.9e-100 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
NEBGOCFH_00983 1.5e-08
NEBGOCFH_00984 6.8e-139 S Abortive infection C-terminus
NEBGOCFH_00985 0.0 L DEAD-like helicases superfamily
NEBGOCFH_00986 1.4e-124 2.1.1.72 V site-specific DNA-methyltransferase (adenine-specific) activity
NEBGOCFH_00987 6.6e-284 XK27_07020 S Belongs to the UPF0371 family
NEBGOCFH_00989 1.1e-37 BP1961 P nitric oxide dioxygenase activity
NEBGOCFH_00990 2.2e-42 K response regulator
NEBGOCFH_00991 9.3e-72 S Signal peptide protein, YSIRK family
NEBGOCFH_00993 4.5e-61
NEBGOCFH_00994 1.8e-270 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NEBGOCFH_00995 1e-137
NEBGOCFH_00996 5.3e-12 IQ PFAM AMP-dependent synthetase and ligase
NEBGOCFH_00997 2.7e-12 IQ PFAM AMP-dependent synthetase and ligase
NEBGOCFH_00998 5.8e-109 MA20_06410 E LysE type translocator
NEBGOCFH_00999 5.6e-08
NEBGOCFH_01000 2.7e-09
NEBGOCFH_01001 0.0 M family 8
NEBGOCFH_01003 1.5e-150 V MatE
NEBGOCFH_01005 3.9e-110 C Fe-S oxidoreductases
NEBGOCFH_01006 1.2e-176 EGP Major Facilitator Superfamily
NEBGOCFH_01007 5.5e-258 I radical SAM domain protein
NEBGOCFH_01009 6.5e-159 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
NEBGOCFH_01010 1.4e-150 L Integrase core domain protein
NEBGOCFH_01011 1.8e-87 L transposase activity
NEBGOCFH_01013 3.5e-52
NEBGOCFH_01014 0.0 sbcC L ATPase involved in DNA repair
NEBGOCFH_01015 2e-230 sbcD L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
NEBGOCFH_01016 0.0 lacL 3.2.1.23 G -beta-galactosidase
NEBGOCFH_01017 0.0 lacS G transporter
NEBGOCFH_01018 2.6e-202 galM 5.1.3.3 G Catalyzes the interconversion of alpha and beta anomers of maltose
NEBGOCFH_01019 6.6e-195 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
NEBGOCFH_01020 4e-289 galT 2.7.7.12 G UDPglucose--hexose-1-phosphate uridylyltransferase
NEBGOCFH_01021 1.6e-221 galK 2.7.1.6 G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NEBGOCFH_01022 2.3e-184 galR K Transcriptional regulator
NEBGOCFH_01023 2.7e-08 L Integrase core domain protein
NEBGOCFH_01024 1.2e-25 L transposition
NEBGOCFH_01025 3.3e-74 M translation initiation factor activity
NEBGOCFH_01026 1.4e-179 zmpB M M26 IgA1-specific Metallo-endopeptidase C-terminal region
NEBGOCFH_01027 5.2e-38 V abc transporter atp-binding protein
NEBGOCFH_01028 9.6e-56 V abc transporter atp-binding protein
NEBGOCFH_01029 2.8e-39 V (ABC) transporter
NEBGOCFH_01030 0.0 gshF 6.3.2.2, 6.3.2.29, 6.3.2.30, 6.3.2.4 H Belongs to the glutamate--cysteine ligase type 1 family
NEBGOCFH_01031 6.4e-62 L Transposase
NEBGOCFH_01032 4.6e-58 pulA 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
NEBGOCFH_01033 6.5e-75 pulA 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
NEBGOCFH_01034 1.8e-33 pulA 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
NEBGOCFH_01035 1.7e-120 pulA 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
NEBGOCFH_01036 0.0 ftsK D Belongs to the FtsK SpoIIIE SftA family
NEBGOCFH_01037 1.6e-188 trxB1 1.18.1.2, 1.19.1.1 C Ferredoxin--NADP reductase
NEBGOCFH_01038 1.4e-135 trmD 2.1.1.228, 4.6.1.12 J Belongs to the RNA methyltransferase TrmD family
NEBGOCFH_01039 5.8e-94 rimM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NEBGOCFH_01042 2.2e-114 vraR K Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
NEBGOCFH_01043 5.8e-175 vraS 2.7.13.3 T Histidine kinase
NEBGOCFH_01044 9.1e-119 yvqF KT membrane
NEBGOCFH_01045 1.6e-306 prkC 2.7.11.1 KLT serine threonine protein kinase
NEBGOCFH_01046 2e-132 stp 3.1.3.16 T phosphatase
NEBGOCFH_01047 4.4e-247 sun 2.1.1.176 J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NEBGOCFH_01048 2.5e-172 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NEBGOCFH_01049 0.0 priA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NEBGOCFH_01050 2.7e-46 rpoZ 2.7.7.6 K DNA-directed 5'-3' RNA polymerase activity
NEBGOCFH_01051 9.8e-112 gmk 2.7.4.8 F Essential for recycling GMP and indirectly, cGMP
NEBGOCFH_01052 2e-213 ftsY U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
NEBGOCFH_01053 5.3e-150 XK27_02985 S overlaps another CDS with the same product name
NEBGOCFH_01054 2.1e-148 supH S overlaps another CDS with the same product name
NEBGOCFH_01055 8.6e-63 yvoA_1 K Transcriptional
NEBGOCFH_01056 9.8e-121 skfE V abc transporter atp-binding protein
NEBGOCFH_01057 5.6e-133 V ATPase activity
NEBGOCFH_01058 7.3e-172 oppF P Belongs to the ABC transporter superfamily
NEBGOCFH_01059 7.9e-202 oppD P Belongs to the ABC transporter superfamily
NEBGOCFH_01060 2.4e-167 amiD P ABC transporter (Permease
NEBGOCFH_01061 1.1e-270 amiC P ABC transporter (Permease
NEBGOCFH_01062 3.1e-159 amiA E ABC transporter, substrate-binding protein, family 5
NEBGOCFH_01064 8.1e-45 L Transposase
NEBGOCFH_01065 4.1e-158 L COG2801 Transposase and inactivated derivatives
NEBGOCFH_01066 1.2e-24 oppF P Belongs to the ABC transporter superfamily
NEBGOCFH_01067 6.5e-45 oppF P Belongs to the ABC transporter superfamily
NEBGOCFH_01068 1.4e-40 tatD L Hydrolase, tatd
NEBGOCFH_01069 6.7e-218 oxlT P COG0477 Permeases of the major facilitator superfamily
NEBGOCFH_01070 1e-110 L Integrase core domain protein
NEBGOCFH_01071 1.1e-23 L transposase activity
NEBGOCFH_01072 5.9e-180 pta 2.3.1.8, 3.6.3.21 C phosphate acetyltransferase
NEBGOCFH_01073 1.1e-172 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 J Responsible for synthesis of pseudouridine from uracil
NEBGOCFH_01074 5.4e-150 nadK 2.7.1.23 H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NEBGOCFH_01075 5.5e-121 yjbM 2.7.6.5 S Gtp pyrophosphokinase
NEBGOCFH_01076 1.5e-103 yjbK S Adenylate cyclase
NEBGOCFH_01077 2.1e-177 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NEBGOCFH_01078 7e-206 iscS 2.8.1.7 E Cysteine desulfurase
NEBGOCFH_01079 2e-58 XK27_04120 S Putative amino acid metabolism
NEBGOCFH_01080 3.6e-117 rex K Modulates transcription in response to changes in cellular NADH NAD( ) redox state
NEBGOCFH_01081 3.9e-130 puuD T peptidase C26
NEBGOCFH_01082 6.2e-120 radC E Belongs to the UPF0758 family
NEBGOCFH_01083 0.0 rgpF M Rhamnan synthesis protein F
NEBGOCFH_01084 3.1e-195 rgpEc GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
NEBGOCFH_01085 8.7e-226 rgpD 3.6.3.38 P Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system
NEBGOCFH_01086 1.4e-142 rgpC GM Transport permease protein
NEBGOCFH_01087 6.3e-179 rgpB GT2 M Glycosyltransferase, group 2 family protein
NEBGOCFH_01088 4.4e-227 rgpA GT4 M Domain of unknown function (DUF1972)
NEBGOCFH_01089 4.6e-139 S Predicted membrane protein (DUF2142)
NEBGOCFH_01090 5.6e-186 tagF 2.7.8.12 M Glycosyl transferase, family 2
NEBGOCFH_01091 9.8e-220 amrA S polysaccharide biosynthetic process
NEBGOCFH_01092 5.3e-48 XK27_09090 S Uncharacterized conserved protein (DUF2304)
NEBGOCFH_01093 2.2e-125 ycbB S Glycosyl transferase family 2
NEBGOCFH_01094 4.5e-160 rfbD 1.1.1.133, 5.1.3.13 M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
NEBGOCFH_01095 2.9e-246
NEBGOCFH_01096 9.5e-172 yfdH GT2 M COG0463, glycosyltransferases involved in cell wall biogenesis
NEBGOCFH_01097 3.4e-55 yitW K metal-sulfur cluster biosynthetic enzyme
NEBGOCFH_01098 1.1e-201 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
NEBGOCFH_01099 0.0 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
NEBGOCFH_01100 5.5e-20 rpsU J Belongs to the bacterial ribosomal protein bS21 family
NEBGOCFH_01101 2.7e-135 gltS ET Belongs to the bacterial solute-binding protein 3 family
NEBGOCFH_01102 2.1e-202 arcT 2.6.1.1 E Aminotransferase
NEBGOCFH_01103 2.5e-136 ET ABC transporter
NEBGOCFH_01104 2.8e-143 ET Belongs to the bacterial solute-binding protein 3 family
NEBGOCFH_01105 2.3e-81 mutT 3.6.1.55 F Nudix family
NEBGOCFH_01106 0.0 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
NEBGOCFH_01108 4.3e-82 S CAAX amino terminal protease family protein
NEBGOCFH_01109 2.4e-33 S CAAX amino terminal protease family protein
NEBGOCFH_01110 0.0 glnP P ABC-type amino acid transport signal transduction systems periplasmic component domain
NEBGOCFH_01111 1e-136 glnQ 3.6.3.21 E abc transporter atp-binding protein
NEBGOCFH_01112 2.4e-16 XK27_00735
NEBGOCFH_01113 1.4e-248 obg S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NEBGOCFH_01115 7.3e-135 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
NEBGOCFH_01118 5.5e-65 paaI Q protein possibly involved in aromatic compounds catabolism
NEBGOCFH_01119 6.6e-30 ycaO O OsmC-like protein
NEBGOCFH_01121 1.7e-154 EG Permeases of the drug metabolite transporter (DMT) superfamily
NEBGOCFH_01123 5.6e-110 csn2 S CRISPR-associated protein (Cas_Csn2)
NEBGOCFH_01124 3.5e-52 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
NEBGOCFH_01125 1.5e-163 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
NEBGOCFH_01126 0.0 cas9 L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
NEBGOCFH_01127 0.0 cas9 L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
NEBGOCFH_01128 4.4e-115 serB 3.1.3.3 E phosphoserine phosphatase
NEBGOCFH_01129 6.4e-299 ezrA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
NEBGOCFH_01130 0.0 gyrB 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NEBGOCFH_01131 2.8e-108 3.1.3.18 S IA, variant 1
NEBGOCFH_01132 2.2e-117 lrgB M effector of murein hydrolase
NEBGOCFH_01133 1.7e-55 lrgA S Effector of murein hydrolase LrgA
NEBGOCFH_01135 6.4e-60 arsC 1.20.4.1 P Belongs to the ArsC family
NEBGOCFH_01136 3.1e-56 ogt 2.1.1.63, 3.2.2.20 L methylated-DNA-[protein]-cysteine S-methyltransferase activity
NEBGOCFH_01137 5.9e-219 serA 1.1.1.399, 1.1.1.95 EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NEBGOCFH_01138 3.9e-104 wecD M Acetyltransferase GNAT family
NEBGOCFH_01139 1.3e-209 serC 2.6.1.52 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NEBGOCFH_01140 5.1e-96 GK ROK family
NEBGOCFH_01141 8.1e-72 gloA 4.4.1.5 E Lactoylglutathione lyase
NEBGOCFH_01142 1.7e-47 XK27_08050 O stress-induced mitochondrial fusion
NEBGOCFH_01143 1.3e-19 XK27_08050 O HflC and HflK could regulate a protease
NEBGOCFH_01144 2.3e-206 potD P spermidine putrescine ABC transporter
NEBGOCFH_01145 3e-134 potC P ABC-type spermidine putrescine transport system, permease component II
NEBGOCFH_01146 3.7e-140 potB P ABC-type spermidine putrescine transport system, permease component I
NEBGOCFH_01147 1.2e-213 potA 3.6.3.30, 3.6.3.31 P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
NEBGOCFH_01148 7.8e-171 murB 1.3.1.98 M cell wall formation
NEBGOCFH_01149 2.9e-87 folK 2.7.6.3, 4.1.2.25 H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NEBGOCFH_01150 1.2e-61 folB 1.13.11.81, 2.5.1.15, 2.7.6.3, 4.1.2.25, 5.1.99.8 H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NEBGOCFH_01151 1.2e-298 amy 3.2.1.1 GH13 G Belongs to the glycosyl hydrolase 13 family
NEBGOCFH_01152 7e-147 folP 2.5.1.15, 2.7.6.3 H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NEBGOCFH_01153 1e-99 folE 3.5.4.16 F gtp cyclohydrolase
NEBGOCFH_01154 0.0 ydaO E amino acid
NEBGOCFH_01155 1.1e-239 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
NEBGOCFH_01156 4.1e-37 ylqC L Belongs to the UPF0109 family
NEBGOCFH_01157 2.4e-43 rpsP J Belongs to the bacterial ribosomal protein bS16 family
NEBGOCFH_01158 6.9e-172 tehB 2.1.1.265 PQ tellurite resistance protein tehb
NEBGOCFH_01159 8.2e-159 xth 3.1.11.2 L exodeoxyribonuclease III
NEBGOCFH_01160 2.1e-74 S QueT transporter
NEBGOCFH_01161 1.9e-55 L Transposase
NEBGOCFH_01162 5.7e-186 yegS 2.7.1.107 I Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
NEBGOCFH_01163 0.0 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NEBGOCFH_01164 3.7e-85 ccl S cog cog4708
NEBGOCFH_01165 7.4e-164 rbn E Belongs to the UPF0761 family
NEBGOCFH_01166 1.5e-166 map 3.4.11.18 E Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed
NEBGOCFH_01167 3.3e-231 ytoI K transcriptional regulator containing CBS domains
NEBGOCFH_01168 2.4e-98 XK27_07830 2.3.1.128 J Acetyltransferase GNAT Family
NEBGOCFH_01169 1e-232 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NEBGOCFH_01170 0.0 comEC S Competence protein ComEC
NEBGOCFH_01171 3e-98 comEA L COG1555 DNA uptake protein and related DNA-binding proteins
NEBGOCFH_01172 3.7e-142 plsC 2.3.1.51 I Acyltransferase
NEBGOCFH_01173 6e-78 nodB3 G polysaccharide deacetylase
NEBGOCFH_01174 4.1e-22 nodB3 G polysaccharide deacetylase
NEBGOCFH_01175 2.3e-139 yabB 2.1.1.223 L Methyltransferase
NEBGOCFH_01176 1e-41 yazA L endonuclease containing a URI domain
NEBGOCFH_01177 3.2e-252 cshA 3.6.4.13 JKL DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
NEBGOCFH_01178 2.3e-154 corA P CorA-like protein
NEBGOCFH_01179 1.9e-62 yjqA S Bacterial PH domain
NEBGOCFH_01180 7.8e-100 thiT S Thiamine transporter
NEBGOCFH_01181 8e-157 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
NEBGOCFH_01182 1.9e-201 yjbB G Permeases of the major facilitator superfamily
NEBGOCFH_01183 3.1e-300 prfC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NEBGOCFH_01184 1.4e-121 ywaF S Integral membrane protein (intg_mem_TP0381)
NEBGOCFH_01185 3e-259 murF 6.3.2.10 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
NEBGOCFH_01189 1.1e-155 cjaA ET ABC transporter substrate-binding protein
NEBGOCFH_01190 1.4e-136 glnQ 3.6.3.21 E abc transporter atp-binding protein
NEBGOCFH_01191 1.3e-114 P ABC transporter (Permease
NEBGOCFH_01192 6.6e-114 papP P ABC transporter (Permease
NEBGOCFH_01193 1.7e-193 ddl 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
NEBGOCFH_01194 4.7e-31 copZ 2.7.7.77 P Heavy metal-associated domain protein
NEBGOCFH_01195 0.0 copA 3.6.3.54 P P-type ATPase
NEBGOCFH_01196 2.7e-73 copY K Copper transport repressor, CopY TcrY family
NEBGOCFH_01197 4.6e-143 trpA 4.2.1.20 E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
NEBGOCFH_01198 5.8e-230 trpB 4.2.1.20, 5.3.1.24 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
NEBGOCFH_01199 3.3e-98 trpF 4.1.1.48, 4.2.1.160, 4.2.1.20, 5.3.1.24 E belongs to the TrpF family
NEBGOCFH_01200 3.2e-133 trpC 4.1.1.48, 5.3.1.24 E Belongs to the TrpC family
NEBGOCFH_01201 7.8e-180 trpD 2.4.2.18, 4.1.3.27 F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NEBGOCFH_01202 1.2e-105 trpG 2.4.2.18, 2.6.1.85, 4.1.3.27 EH anthranilate
NEBGOCFH_01203 2.2e-257 trpE 4.1.3.27 EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NEBGOCFH_01204 1.8e-41 pchB 2.5.1.19, 4.2.1.10, 4.2.99.21, 5.4.99.5 E Chorismate mutase
NEBGOCFH_01205 5.4e-53
NEBGOCFH_01206 0.0 ctpE P E1-E2 ATPase
NEBGOCFH_01207 6.2e-28
NEBGOCFH_01208 1.2e-43 yaaK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NEBGOCFH_01209 9.7e-28 L transposase activity
NEBGOCFH_01210 9.2e-122 K transcriptional regulator, MerR family
NEBGOCFH_01211 1.2e-103 dnaQ 2.7.7.7 L DNA polymerase III
NEBGOCFH_01212 1.2e-41 WQ51_02910 S Protein of unknown function, DUF536
NEBGOCFH_01213 1.6e-63 XK27_02560 S cog cog2151
NEBGOCFH_01214 0.0 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
NEBGOCFH_01215 7.7e-227 ytfP S Flavoprotein
NEBGOCFH_01217 6.9e-121 trmB 2.1.1.297, 2.1.1.33 J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
NEBGOCFH_01218 1.2e-151 ytmP 2.7.1.89 M Phosphotransferase
NEBGOCFH_01219 3e-182 ecsB U ABC transporter
NEBGOCFH_01220 2.3e-133 ecsA V abc transporter atp-binding protein
NEBGOCFH_01221 3.3e-71 hit FG Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
NEBGOCFH_01222 2.3e-10
NEBGOCFH_01223 2.7e-57 S CD20-like family
NEBGOCFH_01224 2e-104
NEBGOCFH_01225 0.0 clpL O ATP-dependent Clp protease ATP-binding subunit
NEBGOCFH_01226 6.9e-206 ylbM S Belongs to the UPF0348 family
NEBGOCFH_01227 2e-140 yqeM Q Methyltransferase domain protein
NEBGOCFH_01228 6e-58 rsfS J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
NEBGOCFH_01229 1.4e-107 nadD 2.7.6.3, 2.7.7.18 H HD superfamily hydrolase involved in NAD metabolism
NEBGOCFH_01230 3.1e-118 nadD 2.7.7.18, 3.6.1.55 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NEBGOCFH_01231 3.5e-49 yhbY J RNA-binding protein
NEBGOCFH_01232 1.7e-215 yqeH S in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis
NEBGOCFH_01233 1.8e-98 yqeG S hydrolase of the HAD superfamily
NEBGOCFH_01234 3.7e-152 yicL EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
NEBGOCFH_01235 1.2e-58
NEBGOCFH_01236 7.8e-274 gatB 6.1.1.12, 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NEBGOCFH_01237 1e-268 gatA 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
NEBGOCFH_01238 1.4e-47 gatC 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NEBGOCFH_01239 8.3e-151 ascB 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
NEBGOCFH_01240 5e-98 ascB 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
NEBGOCFH_01241 4.7e-96 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NEBGOCFH_01242 3.7e-154 hlpA M Belongs to the NlpA lipoprotein family
NEBGOCFH_01243 6.8e-101 pncA Q isochorismatase
NEBGOCFH_01244 1.2e-140 codY K DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
NEBGOCFH_01245 3.7e-240 alaA 2.6.1.2, 2.6.1.66 E Aminotransferase
NEBGOCFH_01246 2.4e-75 XK27_03180 T universal stress protein
NEBGOCFH_01249 2e-157 pflA 1.97.1.4 C Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NEBGOCFH_01250 2e-239 hlyX S COG1253 Hemolysins and related proteins containing CBS domains
NEBGOCFH_01251 2.4e-144 modF 3.6.3.21, 3.6.3.34 P abc transporter atp-binding protein
NEBGOCFH_01252 0.0 yjcE P NhaP-type Na H and K H antiporters
NEBGOCFH_01254 1.4e-98 ytqB 2.1.1.176 J (SAM)-dependent
NEBGOCFH_01255 1.3e-184 yhcC S radical SAM protein
NEBGOCFH_01256 2.2e-196 ylbL T Belongs to the peptidase S16 family
NEBGOCFH_01257 2.7e-88 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NEBGOCFH_01258 5.1e-93 rsmD 2.1.1.171 L Methyltransferase
NEBGOCFH_01259 1.9e-172 trxB 1.8.1.9 C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
NEBGOCFH_01260 1.9e-09 S Protein of unknown function (DUF4059)
NEBGOCFH_01261 4.5e-132 tcyN 3.6.3.21 E abc transporter atp-binding protein
NEBGOCFH_01262 1e-162 yxeN P ABC transporter (Permease
NEBGOCFH_01263 5.7e-152 yxeM ET ABC-type amino acid transport signal transduction systems, periplasmic component domain
NEBGOCFH_01265 3.1e-206 dinB 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NEBGOCFH_01266 0.0 pflB 2.3.1.54 C formate acetyltransferase'
NEBGOCFH_01267 5.2e-147 cah 4.2.1.1 P carbonic anhydrase
NEBGOCFH_01268 2.1e-85 yjcF S COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
NEBGOCFH_01269 1e-44 hsdS_1 3.1.21.3 V type I restriction modification DNA specificity domain
NEBGOCFH_01270 2.9e-87 D nuclear chromosome segregation
NEBGOCFH_01271 1.5e-127 ybbM S transport system, permease component
NEBGOCFH_01272 1.2e-117 ybbL S abc transporter atp-binding protein
NEBGOCFH_01273 4.5e-185 ampC V COG1680 Beta-lactamase class C and other penicillin binding proteins
NEBGOCFH_01274 4.6e-140 cppA E CppA N-terminal
NEBGOCFH_01275 5e-44 V CAAX protease self-immunity
NEBGOCFH_01276 2.3e-164 gla U Belongs to the MIP aquaporin (TC 1.A.8) family
NEBGOCFH_01277 0.0 pepX 3.4.14.11 E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline
NEBGOCFH_01280 3e-47 spiA K sequence-specific DNA binding
NEBGOCFH_01281 2.9e-28 blpT
NEBGOCFH_01282 6.7e-98 blpT
NEBGOCFH_01288 6.7e-26 S Bacteriocin class II with double-glycine leader peptide
NEBGOCFH_01292 7.4e-135 agrA KT phosphorelay signal transduction system
NEBGOCFH_01293 3.4e-239 blpH 2.7.13.3 T protein histidine kinase activity
NEBGOCFH_01295 7.3e-237 mesE M Transport protein ComB
NEBGOCFH_01296 0.0 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
NEBGOCFH_01297 0.0 mdlB V abc transporter atp-binding protein
NEBGOCFH_01298 0.0 mdlA V abc transporter atp-binding protein
NEBGOCFH_01300 1.7e-93 XK27_09885 V Glycopeptide antibiotics resistance protein
NEBGOCFH_01301 3e-223 rlmN 2.1.1.192 J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
NEBGOCFH_01302 1e-64 yutD J protein conserved in bacteria
NEBGOCFH_01303 2.1e-268 yunD 3.1.3.5 F Belongs to the 5'-nucleotidase family
NEBGOCFH_01305 7.2e-221 cshB 3.6.4.13 JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
NEBGOCFH_01306 6.3e-185 mraY 2.7.8.13 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NEBGOCFH_01307 0.0 ftsI 3.4.16.4 M penicillin-binding protein
NEBGOCFH_01308 4.3e-47 ftsL D cell division protein FtsL
NEBGOCFH_01309 3e-157 rsmH 2.1.1.199 J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
NEBGOCFH_01310 1.6e-65
NEBGOCFH_01311 7.4e-27
NEBGOCFH_01312 2.6e-30
NEBGOCFH_01314 8.7e-33 yhaI J Protein of unknown function (DUF805)
NEBGOCFH_01315 4.5e-18 D nuclear chromosome segregation
NEBGOCFH_01316 7.6e-225 proA 1.2.1.41 E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NEBGOCFH_01317 1.7e-140 proB 2.7.2.11 E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NEBGOCFH_01318 6.4e-285 XK27_00765
NEBGOCFH_01319 8.1e-134 ecsA_2 V abc transporter atp-binding protein
NEBGOCFH_01320 5.2e-125 S Protein of unknown function (DUF554)
NEBGOCFH_01321 0.0 addA 3.6.4.12 L ATP-dependent helicase nuclease subunit A
NEBGOCFH_01322 0.0 rexB 3.1.21.3, 3.6.4.12 L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
NEBGOCFH_01323 2.6e-121 liaI S membrane
NEBGOCFH_01324 5.2e-75 XK27_02470 K LytTr DNA-binding domain
NEBGOCFH_01325 3.6e-66 KT response to antibiotic
NEBGOCFH_01326 5.2e-81 yebC M Membrane
NEBGOCFH_01327 2.9e-18 yebC M Membrane
NEBGOCFH_01328 8.1e-260 XK27_03190 5.2.1.8 S hydrolases of the HAD superfamily
NEBGOCFH_01329 3.8e-173 ansA 3.5.1.1 EJ COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D
NEBGOCFH_01331 0.0 recG 3.6.4.12 L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NEBGOCFH_01332 4e-185 alr 5.1.1.1, 5.1.1.5 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NEBGOCFH_01333 4.1e-62 acpS 2.7.6.3, 2.7.8.7, 5.1.1.1 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
NEBGOCFH_01334 1.1e-197 aroF 2.5.1.54 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NEBGOCFH_01335 3.8e-198 aroF 2.5.1.54 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NEBGOCFH_01336 0.0 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
NEBGOCFH_01338 3e-189 manA 5.3.1.8 G mannose-6-phosphate isomerase
NEBGOCFH_01339 4.1e-172 scrK 2.7.1.2, 2.7.1.4 GK Fructokinase
NEBGOCFH_01340 0.0 scrA 2.7.1.208, 2.7.1.211 G pts system
NEBGOCFH_01341 1.2e-290 scrB 3.2.1.26 GH32 G invertase
NEBGOCFH_01342 7.5e-180 scrR K Transcriptional
NEBGOCFH_01343 2.1e-73 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NEBGOCFH_01344 3.4e-62 yqhY S protein conserved in bacteria
NEBGOCFH_01345 1.2e-97 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NEBGOCFH_01346 3.7e-84 comEB 3.5.4.12 F ComE operon protein 2
NEBGOCFH_01347 5e-193 pepP 3.4.11.9, 3.4.13.9 E Belongs to the peptidase M24B family
NEBGOCFH_01349 8e-44 V 'abc transporter, ATP-binding protein
NEBGOCFH_01350 1e-58 V 'abc transporter, ATP-binding protein
NEBGOCFH_01352 0.0 uvrA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NEBGOCFH_01353 2e-169 corA P COG0598 Mg2 and Co2 transporters
NEBGOCFH_01354 3.1e-124 XK27_01040 S Pfam PF06570
NEBGOCFH_01356 9.7e-36 rpsR J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NEBGOCFH_01357 2.7e-91 ssb L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
NEBGOCFH_01358 3.9e-47 rpsF J Binds together with S18 to 16S ribosomal RNA
NEBGOCFH_01359 9.5e-42 XK27_05745
NEBGOCFH_01360 2.5e-230 mutY L A G-specific adenine glycosylase
NEBGOCFH_01365 0.0 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NEBGOCFH_01366 0.0 mutS2 L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
NEBGOCFH_01367 1e-93 cvpA S toxin biosynthetic process
NEBGOCFH_01368 2.3e-13 zapA D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
NEBGOCFH_01369 4.7e-160 rnhC 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NEBGOCFH_01370 1.3e-113 lepB 3.4.21.89 U Belongs to the peptidase S26 family
NEBGOCFH_01371 0.0 recD2 3.1.11.5 L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
NEBGOCFH_01372 2e-47 azlD E branched-chain amino acid
NEBGOCFH_01373 1.8e-114 azlC E AzlC protein
NEBGOCFH_01374 1.1e-186 tsaD 2.3.1.234 O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NEBGOCFH_01375 8.2e-73 rimI 2.3.1.128 K This enzyme acetylates the N-terminal alanine of ribosomal protein S18
NEBGOCFH_01376 5.6e-121 yeaZ 2.3.1.234 O COG1214, inactive homolog of metal-dependent proteases
NEBGOCFH_01377 2.5e-33 ykzG S Belongs to the UPF0356 family
NEBGOCFH_01378 0.0 rnjA S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NEBGOCFH_01379 2.7e-40 pscB M CHAP domain protein
NEBGOCFH_01380 1.5e-263 glnA 6.3.1.2 E glutamine synthetase
NEBGOCFH_01381 8.5e-63 glnR K Transcriptional regulator
NEBGOCFH_01382 1.3e-87 S Fusaric acid resistance protein-like
NEBGOCFH_01383 1.1e-12
NEBGOCFH_01384 2e-222 pgk 2.7.2.3, 5.3.1.1 F Belongs to the phosphoglycerate kinase family
NEBGOCFH_01385 3.2e-42 L Transposase
NEBGOCFH_01386 1.9e-46 L transposase activity
NEBGOCFH_01387 1.7e-54
NEBGOCFH_01389 6.8e-76 isp2 S pathogenesis
NEBGOCFH_01390 5.4e-50 L Transposase
NEBGOCFH_01391 1.7e-111 L Transposase
NEBGOCFH_01392 2.7e-188 gap 1.2.1.12 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
NEBGOCFH_01393 0.0 fusA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NEBGOCFH_01394 6.7e-81 rpsG J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
NEBGOCFH_01395 2.3e-69 rpsL J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NEBGOCFH_01396 1.1e-142 purR 2.4.2.7 F operon repressor
NEBGOCFH_01397 3.6e-179 cbf S 3'-5' exoribonuclease yhaM
NEBGOCFH_01398 6.9e-173 rmuC S RmuC domain protein
NEBGOCFH_01399 3.1e-118 thiN 2.7.6.2 H thiamine pyrophosphokinase
NEBGOCFH_01400 1.1e-118 rpe 5.1.3.1 G Belongs to the ribulose-phosphate 3-epimerase family
NEBGOCFH_01401 1.3e-162 rsgA 3.1.3.100 G One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
NEBGOCFH_01403 8.9e-156 ksgA 2.1.1.182 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
NEBGOCFH_01404 3.2e-98 rnmV 3.1.26.8 J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
NEBGOCFH_01405 1.6e-143 tatD L Hydrolase, tatd
NEBGOCFH_01406 7.2e-74 yccU S CoA-binding protein
NEBGOCFH_01407 4.8e-51 trxA O Belongs to the thioredoxin family
NEBGOCFH_01408 6.6e-142 S Macro domain protein
NEBGOCFH_01409 2e-09 L thioesterase
NEBGOCFH_01410 2.2e-54 bta 1.8.1.8 CO cell redox homeostasis
NEBGOCFH_01412 1.7e-226 tgt 2.4.2.29 F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
NEBGOCFH_01413 1e-33 L Transposase
NEBGOCFH_01414 1e-13 rpmH J Ribosomal protein L34
NEBGOCFH_01415 1.4e-184 jag S RNA-binding protein
NEBGOCFH_01416 1.7e-140 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
NEBGOCFH_01417 5.9e-55 rnpA 3.1.26.5 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
NEBGOCFH_01418 4.1e-264 argH 4.3.2.1 E Argininosuccinate lyase
NEBGOCFH_01419 2e-230 argG 6.3.4.5 E Belongs to the argininosuccinate synthase family. Type 1 subfamily
NEBGOCFH_01420 2.1e-282 gltX 6.1.1.17, 6.1.1.24 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NEBGOCFH_01421 1.4e-81 amiA E transmembrane transport
NEBGOCFH_01422 7.3e-69 amiA E transmembrane transport
NEBGOCFH_01423 4.8e-120 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
NEBGOCFH_01424 3.7e-70 rplK J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NEBGOCFH_01425 9.2e-51 S Protein of unknown function (DUF3397)
NEBGOCFH_01426 2e-88 cah 4.2.1.1 P Reversible hydration of carbon dioxide
NEBGOCFH_01427 7.3e-59 WQ51_05710 S Mitochondrial biogenesis AIM24
NEBGOCFH_01428 6.2e-12 WQ51_05710 S Mitochondrial biogenesis AIM24
NEBGOCFH_01429 1.4e-226 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NEBGOCFH_01430 1.1e-80 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
NEBGOCFH_01431 4.7e-20 XK27_09620 S FMN reductase (NADPH) activity
NEBGOCFH_01432 2.8e-76 XK27_09620 S reductase
NEBGOCFH_01433 8.3e-75 XK27_09615 C reductase
NEBGOCFH_01434 2.5e-135 XK27_09615 C reductase
NEBGOCFH_01435 7.9e-72 fnt P Formate nitrite transporter
NEBGOCFH_01436 5.7e-35 fnt P Formate nitrite transporter
NEBGOCFH_01437 1.2e-23 XK27_08585 S Psort location CytoplasmicMembrane, score
NEBGOCFH_01438 2.2e-27 XK27_08585 S Psort location CytoplasmicMembrane, score
NEBGOCFH_01439 7.4e-186 gpsA 1.1.1.94 I Glycerol-3-phosphate dehydrogenase
NEBGOCFH_01440 1.8e-170 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
NEBGOCFH_01441 2.8e-117 gluP 3.4.21.105 O membrane protein (homolog of Drosophila rhomboid)
NEBGOCFH_01442 3.5e-94 ygfA 6.3.3.2 H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NEBGOCFH_01443 3e-220 hipO 3.5.1.47 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
NEBGOCFH_01444 8.1e-59 dapD 2.3.1.117, 2.3.1.89 E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
NEBGOCFH_01445 1.6e-21 S glycolate biosynthetic process
NEBGOCFH_01446 1.5e-64 S phosphatase activity
NEBGOCFH_01447 2e-157 rrmA 2.1.1.187 Q methyltransferase
NEBGOCFH_01450 2.7e-91 tadA 3.5.4.1, 3.5.4.33 FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
NEBGOCFH_01451 5.1e-66 ssb_2 L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
NEBGOCFH_01452 6.4e-37 yeeD O sulfur carrier activity
NEBGOCFH_01453 5.6e-189 yeeE S Sulphur transport
NEBGOCFH_01454 7.9e-114 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
NEBGOCFH_01455 4.2e-55 ytpP 2.7.1.180, 5.3.4.1 CO Thioredoxin
NEBGOCFH_01456 4.1e-09 S Domain of unknown function (DUF4651)
NEBGOCFH_01457 2e-205 pepA 3.4.11.7 G COG1363 Cellulase M and related proteins
NEBGOCFH_01458 3.9e-131 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NEBGOCFH_01459 3.3e-110 S CAAX amino terminal protease family protein
NEBGOCFH_01461 5e-67 V CAAX protease self-immunity
NEBGOCFH_01462 1.4e-33 V CAAX protease self-immunity
NEBGOCFH_01463 8.8e-27 lanR K sequence-specific DNA binding
NEBGOCFH_01464 2.9e-221 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NEBGOCFH_01465 5.9e-177 ytxK 2.1.1.72 L DNA methylase
NEBGOCFH_01466 6.8e-13 comGF U Putative Competence protein ComGF
NEBGOCFH_01467 4e-72 comGF U Competence protein ComGF
NEBGOCFH_01468 1.4e-15 NU Type II secretory pathway pseudopilin
NEBGOCFH_01469 4e-57 cglD NU Competence protein
NEBGOCFH_01470 8.5e-43 comGC U Required for transformation and DNA binding
NEBGOCFH_01471 1.8e-156 cglB U protein transport across the cell outer membrane
NEBGOCFH_01472 2.1e-174 comGA NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NEBGOCFH_01473 2.9e-68 S cog cog4699
NEBGOCFH_01474 0.0 rpoC 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NEBGOCFH_01475 0.0 rpoB 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NEBGOCFH_01476 0.0 pbp1B 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
NEBGOCFH_01477 1.6e-238 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NEBGOCFH_01478 1.6e-196 ilvC 1.1.1.86 H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NEBGOCFH_01479 7.7e-77 ilvN 2.2.1.6 E Acetolactate synthase
NEBGOCFH_01480 0.0 ilvB 2.2.1.6 EH Acetolactate synthase
NEBGOCFH_01481 4.4e-280 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
NEBGOCFH_01482 3.3e-11 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
NEBGOCFH_01483 1.7e-304 yloV S kinase related to dihydroxyacetone kinase
NEBGOCFH_01484 1.4e-57 asp S cog cog1302
NEBGOCFH_01485 9.3e-226 norN V Mate efflux family protein
NEBGOCFH_01486 6.4e-279 thrC 4.2.3.1 E Threonine synthase
NEBGOCFH_01487 3.8e-99 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
NEBGOCFH_01488 3.5e-76 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
NEBGOCFH_01489 1.3e-135 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
NEBGOCFH_01490 1.4e-63 adhE 1.1.1.1, 1.2.1.10 C Dehydrogenase
NEBGOCFH_01491 0.0 pepO 3.4.24.71 O Peptidase family M13
NEBGOCFH_01492 2.8e-38 treC 3.2.1.93 GH13 G COG0366 Glycosidases
NEBGOCFH_01493 1.2e-69 treC 3.2.1.93 GH13 G COG0366 Glycosidases
NEBGOCFH_01494 5.9e-66 treC 3.2.1.93 GH13 G COG0366 Glycosidases
NEBGOCFH_01495 1.4e-54 treB 2.7.1.201 G PTS System
NEBGOCFH_01496 5.8e-21 treR K DNA-binding transcription factor activity
NEBGOCFH_01497 8.6e-87 treR K trehalose operon
NEBGOCFH_01498 5.7e-95 ywlG S Belongs to the UPF0340 family
NEBGOCFH_01501 2.7e-13 L PFAM Integrase, catalytic core
NEBGOCFH_01502 2.5e-72 L PFAM Integrase, catalytic core
NEBGOCFH_01503 3.3e-46 K Putative DNA-binding domain
NEBGOCFH_01504 2.5e-13 2.3.1.82 M Acetyltransferase GNAT Family
NEBGOCFH_01505 1.2e-126 gltT C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
NEBGOCFH_01506 6.4e-136 HJ the current gene model (or a revised gene model) may contain a frame shift
NEBGOCFH_01511 1e-39
NEBGOCFH_01512 6.5e-31
NEBGOCFH_01513 1.3e-31 S Hypothetical protein (DUF2513)
NEBGOCFH_01514 7.7e-13
NEBGOCFH_01516 5.7e-217 S MvaI/BcnI restriction endonuclease family
NEBGOCFH_01518 2.2e-282 dcm 2.1.1.37 H C-5 cytosine-specific DNA methylase
NEBGOCFH_01519 9e-164 fba 4.1.2.13, 4.1.2.29 G aldolase
NEBGOCFH_01521 7.4e-109 6.3.2.2 H ergothioneine biosynthetic process
NEBGOCFH_01522 1.5e-65 6.3.2.2 H gamma-glutamylcysteine synthetase
NEBGOCFH_01523 3.2e-12 6.3.2.2 H gamma-glutamylcysteine synthetase
NEBGOCFH_01524 3.3e-09 L PFAM Integrase, catalytic core
NEBGOCFH_01525 1.8e-111 L PFAM Integrase, catalytic core
NEBGOCFH_01526 3.3e-62 rplQ J ribosomal protein l17
NEBGOCFH_01527 4.8e-171 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NEBGOCFH_01528 9.6e-62 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NEBGOCFH_01529 4e-57 rpsM J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NEBGOCFH_01530 6e-15 rpmJ J Belongs to the bacterial ribosomal protein bL36 family
NEBGOCFH_01531 2.7e-32 infA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NEBGOCFH_01532 9.2e-121 adk 2.7.4.3 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
NEBGOCFH_01533 9.6e-231 secY U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
NEBGOCFH_01534 4.4e-58 rplO J binds to the 23S rRNA
NEBGOCFH_01535 2.5e-23 rpmD J ribosomal protein l30
NEBGOCFH_01536 1.7e-79 rpsE J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NEBGOCFH_01537 1.9e-56 rplR J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NEBGOCFH_01538 2.3e-93 rplF J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NEBGOCFH_01539 1.2e-67 rpsH J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NEBGOCFH_01540 1.5e-28 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NEBGOCFH_01541 1.6e-94 rplE J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NEBGOCFH_01542 1.4e-47 rplX J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NEBGOCFH_01543 1.1e-59 rplN J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NEBGOCFH_01544 6e-39 rpsQ J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NEBGOCFH_01545 2.7e-26 rpmC J Belongs to the universal ribosomal protein uL29 family
NEBGOCFH_01546 7.2e-71 rplP J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NEBGOCFH_01547 2.1e-117 rpsC J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NEBGOCFH_01548 7.3e-53 rplV J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NEBGOCFH_01549 4.9e-47 rpsS J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NEBGOCFH_01550 8.8e-153 rplB J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NEBGOCFH_01551 2.4e-44 rplW J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
NEBGOCFH_01552 5.7e-104 rplD J Forms part of the polypeptide exit tunnel
NEBGOCFH_01553 1.8e-110 rplC J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NEBGOCFH_01554 2.9e-48 rpsJ J Involved in the binding of tRNA to the ribosomes
NEBGOCFH_01555 7.8e-188 ruvB 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
NEBGOCFH_01556 0.0 XK27_09800 I Acyltransferase
NEBGOCFH_01557 1.7e-35 XK27_09805 S MORN repeat protein
NEBGOCFH_01558 1e-80 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NEBGOCFH_01559 4.1e-250 purA 6.3.4.4 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NEBGOCFH_01560 5.4e-197 L transposase, IS4 family
NEBGOCFH_01561 1.4e-41 adk 2.7.4.3 F topology modulation protein
NEBGOCFH_01562 3.1e-172 yxaM EGP Major facilitator Superfamily
NEBGOCFH_01563 1.9e-197 2.7.7.73, 2.7.7.80 H Involved in molybdopterin and thiamine biosynthesis, family 2
NEBGOCFH_01565 3.4e-155 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
NEBGOCFH_01566 0.0 KLT serine threonine protein kinase
NEBGOCFH_01567 2.1e-280 V ABC transporter
NEBGOCFH_01568 2.7e-12 Z012_04635 K Transcriptional activator, Rgg GadR MutR family
NEBGOCFH_01569 1.4e-127 Z012_04635 K sequence-specific DNA binding
NEBGOCFH_01571 6.3e-16 C Radical SAM
NEBGOCFH_01572 3.4e-191 C Radical SAM
NEBGOCFH_01573 3.9e-287 V ABC transporter transmembrane region
NEBGOCFH_01574 2.5e-89 K sequence-specific DNA binding
NEBGOCFH_01575 2.2e-132 int L Belongs to the 'phage' integrase family
NEBGOCFH_01577 5.2e-237 rarA L ATPase related to the helicase subunit of the Holliday junction resolvase
NEBGOCFH_01578 8.4e-27 rpmB J Belongs to the bacterial ribosomal protein bL28 family
NEBGOCFH_01579 2.8e-44 yrzL S Belongs to the UPF0297 family
NEBGOCFH_01580 1.2e-70 yqgF L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NEBGOCFH_01581 4.2e-44 yrzB S Belongs to the UPF0473 family
NEBGOCFH_01582 2.6e-297 ccs S the current gene model (or a revised gene model) may contain a frame shift
NEBGOCFH_01583 0.0 nrdD 1.1.98.6 F Ribonucleoside-triphosphate reductase
NEBGOCFH_01584 7.5e-14
NEBGOCFH_01585 3.4e-91 XK27_10930 K acetyltransferase
NEBGOCFH_01586 3.7e-116 nrdG 1.97.1.4 O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NEBGOCFH_01587 1.8e-147 yaaA S Belongs to the UPF0246 family
NEBGOCFH_01588 9.3e-167 XK27_01785 S cog cog1284
NEBGOCFH_01589 0.0 aspS 6.1.1.12 J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
NEBGOCFH_01591 1.6e-241 hisS 6.1.1.21 J histidyl-tRNA synthetase
NEBGOCFH_01592 1.4e-53 metE 2.1.1.14 E Methionine synthase
NEBGOCFH_01593 5.2e-55 metE 2.1.1.14 E Methionine synthase
NEBGOCFH_01594 1.4e-14 metE 2.1.1.14 E Methionine synthase
NEBGOCFH_01595 1e-24 rpmF J Belongs to the bacterial ribosomal protein bL32 family
NEBGOCFH_01596 6.7e-19 rpmG J Belongs to the bacterial ribosomal protein bL33 family
NEBGOCFH_01599 3.1e-20 yegS 2.7.1.107 I lipid kinase activity
NEBGOCFH_01600 2.7e-95 S Hydrophobic domain protein
NEBGOCFH_01602 3.7e-27 S Membrane
NEBGOCFH_01603 3.1e-101
NEBGOCFH_01604 1.8e-23 S Small integral membrane protein
NEBGOCFH_01605 1.1e-71 M Protein conserved in bacteria
NEBGOCFH_01606 4.9e-12 K CsbD-like
NEBGOCFH_01607 1.7e-96 nudL L hydrolase
NEBGOCFH_01608 3.4e-13 nudL L hydrolase
NEBGOCFH_01609 2.6e-18 K negative regulation of transcription, DNA-templated
NEBGOCFH_01610 1.7e-23 K negative regulation of transcription, DNA-templated
NEBGOCFH_01612 1.8e-19 XK27_06920 S Protein of unknown function (DUF1700)
NEBGOCFH_01613 1.8e-88 S Putative adhesin
NEBGOCFH_01614 2.5e-160 XK27_06930 V domain protein
NEBGOCFH_01615 6.4e-96 XK27_06935 K transcriptional regulator
NEBGOCFH_01616 4.8e-55 ypaA M Membrane
NEBGOCFH_01617 2.7e-08
NEBGOCFH_01618 9.8e-109 rpsD J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NEBGOCFH_01619 8.2e-48 veg S Biofilm formation stimulator VEG
NEBGOCFH_01620 1.5e-245 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
NEBGOCFH_01621 3.9e-70 rplI J binds to the 23S rRNA
NEBGOCFH_01622 0.0 yybT T signaling protein consisting of a modified GGDEF domain and a DHH domain
NEBGOCFH_01623 0.0 gidA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
NEBGOCFH_01624 1.5e-77 F NUDIX domain
NEBGOCFH_01625 8.6e-220 mnmA 2.8.1.13 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
NEBGOCFH_01626 0.0 S Bacterial membrane protein, YfhO
NEBGOCFH_01627 1.5e-91 isaA GH23 M Immunodominant staphylococcal antigen A
NEBGOCFH_01628 5.3e-85 lytE M LysM domain protein
NEBGOCFH_01629 2e-138 ecfT P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NEBGOCFH_01630 5.2e-153 ecfA2 3.6.3.55 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NEBGOCFH_01631 1.5e-152 ecfA1 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NEBGOCFH_01632 3.1e-90 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NEBGOCFH_01633 6.3e-138 ymfM S sequence-specific DNA binding
NEBGOCFH_01634 3.1e-242 ymfH S Peptidase M16
NEBGOCFH_01635 1e-72 ymfF S Peptidase M16
NEBGOCFH_01636 4.8e-134 ymfF S Peptidase M16
NEBGOCFH_01637 4.7e-45 yaaA S S4 domain protein YaaA
NEBGOCFH_01638 7.7e-205 recF L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NEBGOCFH_01639 4.3e-275 guaB 1.1.1.205 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
NEBGOCFH_01640 6.3e-193 trpS 6.1.1.2 J Tryptophanyl-tRNA synthetase
NEBGOCFH_01641 4.2e-153 yvjA S membrane
NEBGOCFH_01642 6.7e-306 ybiT S abc transporter atp-binding protein
NEBGOCFH_01643 0.0 XK27_10405 S Bacterial membrane protein YfhO
NEBGOCFH_01647 6.2e-120 yoaK S Psort location CytoplasmicMembrane, score
NEBGOCFH_01648 3.3e-86 rlmH 2.1.1.177 J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NEBGOCFH_01649 2.6e-193 htrA 3.4.21.107 O Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain'
NEBGOCFH_01650 8.5e-134 parB K Belongs to the ParB family
NEBGOCFH_01651 1.3e-257 dnaA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NEBGOCFH_01652 6.3e-202 dnaN 2.7.7.7 L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
NEBGOCFH_01653 1.1e-29 yyzM S Protein conserved in bacteria
NEBGOCFH_01654 1.1e-203 ychF J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
NEBGOCFH_01655 1.4e-104 pth 3.1.1.29 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
NEBGOCFH_01656 0.0 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NEBGOCFH_01657 1.7e-39 yabO J Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
NEBGOCFH_01658 2.7e-61 divIC D Septum formation initiator
NEBGOCFH_01660 5.1e-240 XK27_09285 3.5.2.6 V Beta-lactamase enzyme family
NEBGOCFH_01661 7.2e-239 tilS 2.4.2.8, 6.3.4.19 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
NEBGOCFH_01662 3.4e-97 hpt 2.4.2.8, 6.3.4.19 F Belongs to the purine pyrimidine phosphoribosyltransferase family
NEBGOCFH_01663 0.0 ftsH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NEBGOCFH_01664 3.7e-106 L Transposase
NEBGOCFH_01665 6.3e-28 L Transposase
NEBGOCFH_01666 1.9e-92 L Transposase
NEBGOCFH_01668 6.5e-34 L Integrase core domain protein
NEBGOCFH_01669 5.1e-114 L Integrase core domain protein
NEBGOCFH_01670 1.9e-50 L Helix-turn-helix domain
NEBGOCFH_01671 1.6e-249 L Transposase
NEBGOCFH_01672 1.8e-79 tnpR L Resolvase, N terminal domain
NEBGOCFH_01673 2.3e-27 S Protein of unknown function (DUF2568)
NEBGOCFH_01674 3.3e-247 G polysaccharide deacetylase
NEBGOCFH_01675 1e-30 dhaL 2.7.1.121 G Dihydroxyacetone kinase
NEBGOCFH_01676 2.9e-125 tnp L Transposase IS66 family
NEBGOCFH_01677 2.5e-225 capA M Bacterial capsule synthesis protein
NEBGOCFH_01678 6.1e-39 gcvR T UPF0237 protein
NEBGOCFH_01679 8.7e-243 XK27_08635 S UPF0210 protein
NEBGOCFH_01680 5.4e-135 ais G Phosphoglycerate mutase
NEBGOCFH_01681 2.1e-143 vanY 3.4.17.14 M D-alanyl-D-alanine carboxypeptidase
NEBGOCFH_01682 1.3e-102 acmA 3.2.1.17 NU amidase activity
NEBGOCFH_01683 5.3e-198 hrcA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
NEBGOCFH_01684 1.3e-71 grpE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NEBGOCFH_01685 9.8e-298 dnaK O Heat shock 70 kDa protein
NEBGOCFH_01686 4.2e-190 dnaJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
NEBGOCFH_01687 2.5e-138 truA 5.4.99.12 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
NEBGOCFH_01688 1.6e-137 thiD 2.7.1.35, 2.7.1.49, 2.7.4.7 H phosphomethylpyrimidine kinase
NEBGOCFH_01689 2.5e-30 hmpT S membrane
NEBGOCFH_01690 1.2e-165 L integrase core domain
NEBGOCFH_01691 9.9e-19 S Domain of unknown function (DUF4649)
NEBGOCFH_01692 1.8e-56 amd 3.5.1.47 E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
NEBGOCFH_01693 1.5e-233 cfa 2.1.1.317, 2.1.1.79 M cyclopropane-fatty-acyl-phospholipid synthase
NEBGOCFH_01694 1e-84
NEBGOCFH_01695 1.6e-77 sigH K DNA-templated transcription, initiation
NEBGOCFH_01696 3e-148 ykuT M mechanosensitive ion channel
NEBGOCFH_01697 1.4e-218 tig D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
NEBGOCFH_01698 4.8e-73 rpoE K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
NEBGOCFH_01699 7.6e-310 pyrG 6.3.4.2 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
NEBGOCFH_01700 1.3e-84 XK27_03960 S Protein of unknown function (DUF3013)
NEBGOCFH_01701 3.7e-81 mutT3 3.6.1.13, 3.6.1.55 L NUDIX domain
NEBGOCFH_01702 2e-177 prmA J Ribosomal protein L11 methyltransferase
NEBGOCFH_01703 4.4e-135 rsmE 2.1.1.193 J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
NEBGOCFH_01704 1.4e-42 F nucleotide catabolic process
NEBGOCFH_01705 5.4e-139 cpdB 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
NEBGOCFH_01706 7.7e-140 cpdB 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
NEBGOCFH_01707 2.3e-51 cpdB 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
NEBGOCFH_01708 1.8e-83 nrdI F Belongs to the NrdI family
NEBGOCFH_01709 0.0 relA 2.7.6.5 KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NEBGOCFH_01710 2.3e-75 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
NEBGOCFH_01711 1.4e-09 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
NEBGOCFH_01712 2e-27 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
NEBGOCFH_01713 5.6e-59 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
NEBGOCFH_01714 1.1e-45 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
NEBGOCFH_01715 2.3e-237 ilvA 4.3.1.19 E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NEBGOCFH_01716 3.3e-112 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
NEBGOCFH_01717 1.2e-112 fnr5 K Catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
NEBGOCFH_01718 9.3e-201 yhjX P Major Facilitator
NEBGOCFH_01719 9.2e-43 rpsO J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NEBGOCFH_01720 5e-94 V VanZ like family
NEBGOCFH_01723 1e-123 glnQ E abc transporter atp-binding protein
NEBGOCFH_01724 2.9e-274 glnP P ABC transporter
NEBGOCFH_01725 1.5e-152 uppP 3.6.1.27 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
NEBGOCFH_01726 2.3e-136 mecA NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
NEBGOCFH_01727 1.1e-185 tagO 2.7.8.33, 2.7.8.35 M transferase
NEBGOCFH_01728 9.5e-144 sufC O ABC-type transport system involved in Fe-S cluster assembly, ATPase component
NEBGOCFH_01729 6.3e-235 sufD O assembly protein SufD
NEBGOCFH_01730 2.3e-237 sufS 2.8.1.7, 4.4.1.16 E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NEBGOCFH_01731 2.5e-74 nifU C SUF system FeS assembly protein, NifU family
NEBGOCFH_01732 2.2e-273 sufB O assembly protein SufB
NEBGOCFH_01733 7e-10 oppA E ABC transporter substrate-binding protein
NEBGOCFH_01734 2e-138 oppA E ABC transporter substrate-binding protein
NEBGOCFH_01735 4.2e-27 oppB P ABC-type dipeptide oligopeptide nickel transport systems, permease components
NEBGOCFH_01736 6.6e-11 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
NEBGOCFH_01737 1.7e-33 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
NEBGOCFH_01738 1.4e-38 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
NEBGOCFH_01739 3e-27 oppD P Belongs to the ABC transporter superfamily
NEBGOCFH_01740 2.5e-32 oppD P Belongs to the ABC transporter superfamily
NEBGOCFH_01741 1.7e-61 oppD P Belongs to the ABC transporter superfamily
NEBGOCFH_01742 3.1e-43 oppD P Belongs to the ABC transporter superfamily
NEBGOCFH_01743 7.5e-62 oppF P Belongs to the ABC transporter superfamily
NEBGOCFH_01744 4.7e-64 oppF P Belongs to the ABC transporter superfamily
NEBGOCFH_01747 1.9e-158 hslO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NEBGOCFH_01748 7.4e-183 dus J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NEBGOCFH_01749 1.9e-223 EGP Major facilitator Superfamily
NEBGOCFH_01750 3.1e-72 adcR K transcriptional
NEBGOCFH_01751 6.4e-136 adcC P ABC transporter, ATP-binding protein
NEBGOCFH_01752 1.6e-127 adcB P ABC transporter (Permease
NEBGOCFH_01753 1.4e-162 mleP2 S Transporter, auxin efflux carrier (AEC) family protein
NEBGOCFH_01754 5.6e-65 ptsG 2.7.1.199, 2.7.1.208 G pts system
NEBGOCFH_01755 6e-150 ptsG 2.7.1.199, 2.7.1.208, 2.7.1.211 G pts system
NEBGOCFH_01756 3.6e-106 ptsG 2.7.1.199, 2.7.1.208, 2.7.1.211 G phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1
NEBGOCFH_01757 6.8e-158 rgfB 3.1.3.90 L Endonuclease/Exonuclease/phosphatase family
NEBGOCFH_01758 2.8e-257 pgi 5.3.1.9 G Belongs to the GPI family
NEBGOCFH_01759 1.9e-127 yeeN K transcriptional regulatory protein
NEBGOCFH_01760 9.8e-50 yajC U protein transport
NEBGOCFH_01761 1.1e-141 uppS 2.5.1.31 H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NEBGOCFH_01762 2.2e-145 cdsA 2.7.7.41 S Belongs to the CDS family
NEBGOCFH_01763 1.4e-231 rseP 3.4.21.107, 3.4.21.116 M zinc metalloprotease
NEBGOCFH_01764 0.0 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
NEBGOCFH_01765 0.0 WQ51_06230 S ABC transporter substrate binding protein
NEBGOCFH_01766 5.2e-142 cmpC S abc transporter atp-binding protein
NEBGOCFH_01767 1.3e-42 groS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NEBGOCFH_01768 4.1e-287 groL O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
NEBGOCFH_01769 4.4e-37 L Transposase
NEBGOCFH_01770 6.4e-18 L transposase activity
NEBGOCFH_01773 6.1e-43
NEBGOCFH_01774 6.8e-56 S TM2 domain
NEBGOCFH_01775 1.2e-165 rluA 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
NEBGOCFH_01776 0.0 pbp2A 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
NEBGOCFH_01777 5.7e-25 secE U Belongs to the SecE SEC61-gamma family
NEBGOCFH_01778 8.4e-96 nusG K Participates in transcription elongation, termination and antitermination
NEBGOCFH_01779 4.6e-85 3.1.3.27, 3.1.3.4, 3.1.3.81, 3.6.1.27 I phosphatidate phosphatase activity
NEBGOCFH_01780 6e-55 cof Q phosphatase activity
NEBGOCFH_01781 6.2e-35 cof Q phosphatase activity
NEBGOCFH_01782 1.6e-137 glcR K transcriptional regulator (DeoR family)
NEBGOCFH_01783 0.0 leuS 6.1.1.4 J Belongs to the class-I aminoacyl-tRNA synthetase family
NEBGOCFH_01784 3.8e-40 K transcriptional
NEBGOCFH_01786 2.6e-76 S thiolester hydrolase activity
NEBGOCFH_01787 1e-139 S COG1073 Hydrolases of the alpha beta superfamily
NEBGOCFH_01788 1.3e-276 pncB 6.3.4.21 H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NEBGOCFH_01789 2.1e-151 nadE 6.3.1.5 H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
NEBGOCFH_01790 3.2e-77 yhaI L Membrane
NEBGOCFH_01791 5.1e-259 pepC 3.4.22.40 E aminopeptidase
NEBGOCFH_01792 0.0 ponA 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
NEBGOCFH_01793 2.4e-107 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
NEBGOCFH_01794 4.9e-93 ypsA S Belongs to the UPF0398 family
NEBGOCFH_01795 5.1e-51 gpsB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
NEBGOCFH_01796 1.5e-222 rlmL 2.1.1.173, 2.1.1.264 L Belongs to the methyltransferase superfamily
NEBGOCFH_01797 1.2e-295 mapZ D Early cell division protein that marks the future cell division site and supports proper FtsZ ring positioning
NEBGOCFH_01798 0.0 snf 2.7.11.1 L Superfamily II DNA RNA helicases, SNF2 family'
NEBGOCFH_01799 2.5e-23
NEBGOCFH_01800 9.8e-255 mpl 6.3.2.4, 6.3.2.45, 6.3.2.8 M Belongs to the MurCDEF family
NEBGOCFH_01801 3.5e-82 XK27_09675 K -acetyltransferase
NEBGOCFH_01802 0.0 mltG ADL Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NEBGOCFH_01803 1.6e-77 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
NEBGOCFH_01804 5.2e-59 L Integrase core domain protein
NEBGOCFH_01805 2.9e-165 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
NEBGOCFH_01806 7e-46 acyP 3.6.1.7 C Belongs to the acylphosphatase family
NEBGOCFH_01807 6.4e-131 spoU 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NEBGOCFH_01808 4.7e-93 XK27_09705 6.1.1.14 S HD superfamily hydrolase
NEBGOCFH_01809 1.5e-97 ybhL S Belongs to the BI1 family
NEBGOCFH_01812 1.6e-243 lysA 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
NEBGOCFH_01813 1e-88 K transcriptional regulator
NEBGOCFH_01814 7.6e-36 yneF S UPF0154 protein
NEBGOCFH_01815 1.9e-147 murI 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
NEBGOCFH_01816 6.6e-184 rdgB 3.6.1.66, 5.1.1.3 F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NEBGOCFH_01817 3.5e-99 XK27_09740 S Phosphoesterase
NEBGOCFH_01818 7.8e-85 ykuL S CBS domain
NEBGOCFH_01819 4.5e-135 xerD L tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site
NEBGOCFH_01820 3.8e-120 scpA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NEBGOCFH_01821 3e-99 scpB D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NEBGOCFH_01822 6.1e-140 rluB 5.4.99.19, 5.4.99.21, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
NEBGOCFH_01823 1.2e-39 yidD S Could be involved in insertion of integral membrane proteins into the membrane
NEBGOCFH_01824 1.2e-258 trkH P Cation transport protein
NEBGOCFH_01825 1.5e-247 trkA P Potassium transporter peripheral membrane component
NEBGOCFH_01826 7.9e-96 trmL 2.1.1.207 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
NEBGOCFH_01827 3.9e-88 ribU U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
NEBGOCFH_01828 2.4e-113 bcrC 3.6.1.27 I Membrane-associated phospholipid phosphatase
NEBGOCFH_01829 3.3e-161 K sequence-specific DNA binding
NEBGOCFH_01830 1.9e-33 V protein secretion by the type I secretion system
NEBGOCFH_01831 3.4e-62 V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
NEBGOCFH_01832 1.1e-36 V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
NEBGOCFH_01833 6.4e-67 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
NEBGOCFH_01834 3.7e-22 yhaI L Membrane
NEBGOCFH_01835 9.4e-54 S Domain of unknown function (DUF4173)
NEBGOCFH_01836 6.8e-95 ureI S AmiS/UreI family transporter
NEBGOCFH_01837 7.6e-46 ureA 3.5.1.5 E Belongs to the urease gamma subunit family
NEBGOCFH_01838 7.8e-54 ureB 3.5.1.5 E Belongs to the urease beta subunit family
NEBGOCFH_01839 0.0 ureC 3.5.1.5 E Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family
NEBGOCFH_01840 6.6e-78 ureE O enzyme active site formation
NEBGOCFH_01841 1.5e-129 ureF O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
NEBGOCFH_01842 9.5e-112 ureG KO Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NEBGOCFH_01843 1.3e-159 ureD O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
NEBGOCFH_01844 2.7e-177 cbiM P PDGLE domain
NEBGOCFH_01845 6e-135 P cobalt transport protein
NEBGOCFH_01846 3.1e-130 cbiO P ABC transporter
NEBGOCFH_01847 1.6e-22 ET amino acid transport
NEBGOCFH_01848 2.3e-116 ET amino acid transport
NEBGOCFH_01849 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
NEBGOCFH_01850 0.0 3.3.1.1, 3.6.1.55, 3.6.1.67 F NUDIX domain
NEBGOCFH_01851 3.8e-205 EGP Transmembrane secretion effector
NEBGOCFH_01852 4e-153 ET amino acid transport
NEBGOCFH_01853 3.7e-165 metQ M Belongs to the NlpA lipoprotein family
NEBGOCFH_01854 1.1e-86 dapE 3.5.1.18 E COG0624, acetylornithine deacetylase succinyl-diaminopimelate desuccinylase and related deacylases
NEBGOCFH_01855 1.2e-61 dapE 3.5.1.18 E succinyl-diaminopimelate desuccinylase activity
NEBGOCFH_01856 1e-63 dapE 3.5.1.18 E succinyl-diaminopimelate desuccinylase activity
NEBGOCFH_01857 1.2e-189 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NEBGOCFH_01858 3e-98 metI P ABC transporter (Permease
NEBGOCFH_01859 4.6e-211 sstT E Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
NEBGOCFH_01860 3.2e-158 salL 2.5.1.63, 2.5.1.94 S S-adenosyl-l-methionine hydroxide adenosyltransferase
NEBGOCFH_01861 9.4e-95 S UPF0397 protein
NEBGOCFH_01862 0.0 ykoD P abc transporter atp-binding protein
NEBGOCFH_01863 1.2e-146 cbiQ P cobalt transport
NEBGOCFH_01864 0.0 tkt 2.2.1.1 G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NEBGOCFH_01865 9.7e-13 ulaG S L-ascorbate 6-phosphate lactonase
NEBGOCFH_01866 5.5e-121 ktrA P COG0569 K transport systems, NAD-binding component
NEBGOCFH_01867 5.2e-243 P COG0168 Trk-type K transport systems, membrane components
NEBGOCFH_01868 1.1e-130 rsmG 2.1.1.170 J Ribosomal RNA small subunit methyltransferase G
NEBGOCFH_01869 2.1e-91 yceD K metal-binding, possibly nucleic acid-binding protein
NEBGOCFH_01870 1.8e-122 T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
NEBGOCFH_01871 6.3e-282 T PhoQ Sensor
NEBGOCFH_01872 4.7e-82 nrdR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NEBGOCFH_01873 6.5e-218 dnaB L Replication initiation and membrane attachment
NEBGOCFH_01874 5.2e-167 dnaI L Primosomal protein DnaI
NEBGOCFH_01875 2e-247 der 1.1.1.399, 1.1.1.95 S GTPase that plays an essential role in the late steps of ribosome biogenesis
NEBGOCFH_01877 1.2e-34
NEBGOCFH_01878 6.7e-14 yrdC 3.5.1.19 Q isochorismatase
NEBGOCFH_01879 3e-27 L Integrase core domain protein
NEBGOCFH_01880 5.7e-23 L Transposase
NEBGOCFH_01881 7.8e-28 L transposase activity
NEBGOCFH_01882 8.6e-232 serS 6.1.1.11 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NEBGOCFH_01883 4.2e-62 manO S protein conserved in bacteria
NEBGOCFH_01884 6.2e-168 manN G PTS system mannose fructose sorbose family IID component
NEBGOCFH_01885 2.3e-116 manM G pts system
NEBGOCFH_01886 1.3e-174 manL 2.7.1.191 G pts system
NEBGOCFH_01887 9.8e-140 XK27_00940 1.2.1.70, 3.5.1.9 S Metal-dependent hydrolase
NEBGOCFH_01888 5.6e-152 yitU 3.1.3.104 S hydrolases of the HAD superfamily
NEBGOCFH_01889 2.1e-247 pbuO S permease
NEBGOCFH_01890 1.4e-77 ydiB 2.7.1.221, 5.1.1.1 M ATPase or kinase
NEBGOCFH_01891 2.4e-92 XK27_05885 2.3.1.82 M Acetyltransferase GNAT Family
NEBGOCFH_01892 2.5e-220 brpA K Transcriptional
NEBGOCFH_01893 3.9e-81 rimP S Required for maturation of 30S ribosomal subunits
NEBGOCFH_01894 3.1e-212 nusA K Participates in both transcription termination and antitermination
NEBGOCFH_01895 1e-47 ylxR K Nucleic-acid-binding protein implicated in transcription termination
NEBGOCFH_01896 1.4e-41 ylxQ J ribosomal protein
NEBGOCFH_01897 0.0 infB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NEBGOCFH_01898 6.6e-57 rbfA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NEBGOCFH_01899 7.6e-74 yvdD 3.2.2.10 S Belongs to the LOG family
NEBGOCFH_01901 2.6e-225 femA 2.3.2.10, 2.3.2.16, 2.3.2.17, 2.3.2.18 V protein involved in methicillin resistance
NEBGOCFH_01902 4.9e-276 murE 6.3.2.13, 6.3.2.7 M to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NEBGOCFH_01903 4.5e-283 ytgP S Membrane protein involved in the export of O-antigen and teichoic acid
NEBGOCFH_01904 3.3e-96 pacL 3.6.3.8, 3.6.3.9 P cation transport ATPase
NEBGOCFH_01905 6.1e-202 metB 2.5.1.48, 4.4.1.8 E cystathionine
NEBGOCFH_01906 6.6e-223 malY 4.4.1.8 E COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
NEBGOCFH_01908 1.2e-08 sacB 2.4.1.10, 2.4.1.9, 3.2.1.26 GH32,GH68 G Belongs to the glycosyl hydrolase 68 family
NEBGOCFH_01909 4.4e-112 upp 2.4.2.9 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NEBGOCFH_01910 2.9e-105 clpP 3.4.21.92 OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
NEBGOCFH_01911 1.3e-73 ylbF S Belongs to the UPF0342 family
NEBGOCFH_01912 4.6e-45 ylbG S UPF0298 protein
NEBGOCFH_01913 9.1e-212 livJ E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component
NEBGOCFH_01914 1.9e-145 livH E Belongs to the binding-protein-dependent transport system permease family
NEBGOCFH_01915 1.4e-138 livM E Belongs to the binding-protein-dependent transport system permease family
NEBGOCFH_01916 9.6e-138 livG E COG0411 ABC-type branched-chain amino acid transport systems, ATPase component
NEBGOCFH_01917 4.8e-123 livF E COG0410 ABC-type branched-chain amino acid transport systems, ATPase component
NEBGOCFH_01918 9.5e-71 acuB S IMP dehydrogenase activity
NEBGOCFH_01919 3.3e-43 acuB S IMP dehydrogenase activity
NEBGOCFH_01920 2.2e-168 cysK 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
NEBGOCFH_01921 1.1e-110 yvyE 3.4.13.9 S YigZ family
NEBGOCFH_01922 4.5e-252 comFA L Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
NEBGOCFH_01923 1.7e-122 comFC S Competence protein
NEBGOCFH_01924 2.1e-94 hpf J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NEBGOCFH_01930 2.1e-166 ppaC 3.6.1.1 C inorganic pyrophosphatase
NEBGOCFH_01931 6.4e-108 S Domain of unknown function (DUF1803)
NEBGOCFH_01932 7.8e-102 ygaC J Belongs to the UPF0374 family
NEBGOCFH_01933 1.2e-130 recX 2.4.1.337 GT4 S Regulatory protein RecX
NEBGOCFH_01934 6.7e-259 rumA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NEBGOCFH_01935 2.3e-192 asnA 6.3.1.1 E aspartate--ammonia ligase

eggNOG-mapper v2 (Database: eggNOG v5.0, Jul. 2018 release)