ORF_ID e_value Gene_name EC_number CAZy COGs Description
HKLECMIN_00001 3.6e-111 mccF V LD-carboxypeptidase
HKLECMIN_00002 1.7e-298 O MreB/Mbl protein
HKLECMIN_00004 5.8e-146 V Psort location CytoplasmicMembrane, score
HKLECMIN_00007 6.8e-14
HKLECMIN_00008 6.1e-233 dcuS 2.7.13.3 T protein histidine kinase activity
HKLECMIN_00009 4e-243 2.7.13.3 T protein histidine kinase activity
HKLECMIN_00010 0.0 rexB 3.1.21.3, 3.6.4.12 L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HKLECMIN_00011 0.0 addA 3.6.4.12 L ATP-dependent helicase nuclease subunit A
HKLECMIN_00012 4e-125 S Protein of unknown function (DUF554)
HKLECMIN_00013 8.1e-134 ecsA_2 V abc transporter atp-binding protein
HKLECMIN_00014 5.8e-286 XK27_00765
HKLECMIN_00015 4.9e-140 proB 2.7.2.11 E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HKLECMIN_00016 4.2e-223 proA 1.2.1.41 E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HKLECMIN_00017 6.4e-53 yhaI J Membrane
HKLECMIN_00018 2.1e-33 yhaI J Protein of unknown function (DUF805)
HKLECMIN_00019 1.7e-16 L Transposase and inactivated derivatives
HKLECMIN_00020 2.9e-86 L Endonuclease
HKLECMIN_00021 1.5e-54 yhaI J Protein of unknown function (DUF805)
HKLECMIN_00022 6.3e-32 yhaI J Protein of unknown function (DUF805)
HKLECMIN_00024 2.4e-94
HKLECMIN_00025 2.6e-172 rsmH 2.1.1.199 J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
HKLECMIN_00026 2.4e-45 ftsL D cell division protein FtsL
HKLECMIN_00027 0.0 ftsI 3.4.16.4 M penicillin-binding protein
HKLECMIN_00028 1.1e-184 mraY 2.7.8.13 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HKLECMIN_00029 3e-219 cshB 3.6.4.13 JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
HKLECMIN_00031 5.3e-248 yunD 3.1.3.5 F Belongs to the 5'-nucleotidase family
HKLECMIN_00032 1.8e-61 yutD J protein conserved in bacteria
HKLECMIN_00033 1.8e-223 rlmN 2.1.1.192 J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HKLECMIN_00034 1.6e-91 XK27_09885 V Glycopeptide antibiotics resistance protein
HKLECMIN_00037 0.0 mdlA V abc transporter atp-binding protein
HKLECMIN_00038 0.0 mdlB V abc transporter atp-binding protein
HKLECMIN_00044 1.8e-44 spiA K sequence-specific DNA binding
HKLECMIN_00045 0.0 pepX 3.4.14.11 E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline
HKLECMIN_00046 5.6e-150 gla U Belongs to the MIP aquaporin (TC 1.A.8) family
HKLECMIN_00047 2e-93 V CAAX protease self-immunity
HKLECMIN_00048 4.7e-137 cppA E CppA N-terminal
HKLECMIN_00049 1.6e-166 ampC V COG1680 Beta-lactamase class C and other penicillin binding proteins
HKLECMIN_00052 1.1e-72 yjcF S COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HKLECMIN_00053 3e-142 cah 4.2.1.1 P carbonic anhydrase
HKLECMIN_00054 0.0 pflB 2.3.1.54 C formate acetyltransferase'
HKLECMIN_00055 1.9e-203 dinB 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HKLECMIN_00056 2.1e-35
HKLECMIN_00057 5.7e-152 yxeM ET ABC-type amino acid transport signal transduction systems, periplasmic component domain
HKLECMIN_00058 6.8e-162 yxeN P ABC transporter (Permease
HKLECMIN_00059 7.2e-130 tcyN 3.6.3.21 E abc transporter atp-binding protein
HKLECMIN_00060 5e-10 S Protein of unknown function (DUF4059)
HKLECMIN_00061 2.1e-171 trxB 1.8.1.9 C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
HKLECMIN_00062 5.6e-92 rsmD 2.1.1.171 L Methyltransferase
HKLECMIN_00063 7.3e-86 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HKLECMIN_00064 1.2e-186 ylbL T Belongs to the peptidase S16 family
HKLECMIN_00065 7.9e-182 yhcC S radical SAM protein
HKLECMIN_00066 1.9e-95 ytqB J (SAM)-dependent
HKLECMIN_00067 1.9e-07
HKLECMIN_00068 0.0 yjcE P NhaP-type Na H and K H antiporters
HKLECMIN_00069 5.6e-141 modF 3.6.3.21, 3.6.3.34 P abc transporter atp-binding protein
HKLECMIN_00070 3.8e-238 hlyX S COG1253 Hemolysins and related proteins containing CBS domains
HKLECMIN_00071 2.5e-10 MU outer membrane autotransporter barrel domain protein
HKLECMIN_00072 2e-157 pflA 1.97.1.4 C Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HKLECMIN_00074 9e-75 XK27_03180 T universal stress protein
HKLECMIN_00075 2.9e-237 alaA 2.6.1.2, 2.6.1.66 E Aminotransferase
HKLECMIN_00076 8.1e-140 codY K DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HKLECMIN_00077 2.9e-99 pncA Q isochorismatase
HKLECMIN_00078 2.6e-293 ascB 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
HKLECMIN_00079 6.7e-218 M lipopolysaccharide 3-alpha-galactosyltransferase activity
HKLECMIN_00080 2.8e-157 H COG0463 Glycosyltransferases involved in cell wall biogenesis
HKLECMIN_00081 2.4e-189 M A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1
HKLECMIN_00082 2.9e-231 2.4.1.52 GT4 M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
HKLECMIN_00083 1.4e-47 gatC 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HKLECMIN_00084 1.7e-268 gatA 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
HKLECMIN_00085 1.3e-273 gatB 6.1.1.12, 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HKLECMIN_00086 1.6e-64
HKLECMIN_00087 5.2e-154 yicL EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
HKLECMIN_00088 4.7e-99 yqeG S hydrolase of the HAD superfamily
HKLECMIN_00089 1.6e-213 yqeH S in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis
HKLECMIN_00090 2.9e-48 yhbY J RNA-binding protein
HKLECMIN_00091 1.2e-117 nadD 2.7.7.18, 3.6.1.55 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HKLECMIN_00092 4.1e-104 nadD 2.7.6.3, 2.7.7.18 H HD superfamily hydrolase involved in NAD metabolism
HKLECMIN_00093 2e-58 rsfS J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
HKLECMIN_00094 1.9e-138 yqeM Q Methyltransferase domain protein
HKLECMIN_00095 5.5e-195 ylbM S Belongs to the UPF0348 family
HKLECMIN_00096 3.4e-39 yefM 2.3.1.15 D Antitoxin component of a toxin-antitoxin (TA) module
HKLECMIN_00097 1.6e-44 yoeB S Addiction module toxin, Txe YoeB family
HKLECMIN_00098 0.0 clpL O ATP-dependent Clp protease ATP-binding subunit
HKLECMIN_00099 4.1e-07
HKLECMIN_00100 8.6e-72 hit FG Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
HKLECMIN_00101 8.9e-133 ecsA V abc transporter atp-binding protein
HKLECMIN_00102 7.1e-176 ecsB U Bacterial ABC transporter protein EcsB
HKLECMIN_00103 7.1e-152 ytmP 2.7.1.89 M Phosphotransferase
HKLECMIN_00104 1.2e-120 trmB 2.1.1.297, 2.1.1.33 J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
HKLECMIN_00106 4e-223 ytfP S Flavoprotein
HKLECMIN_00107 0.0 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
HKLECMIN_00108 8.2e-63 XK27_02560 S cog cog2151
HKLECMIN_00109 9.1e-42 WQ51_02910 S Protein of unknown function, DUF536
HKLECMIN_00110 9.2e-104 dnaQ 2.7.7.7 L DNA polymerase III
HKLECMIN_00111 3.5e-121 K transcriptional regulator, MerR family
HKLECMIN_00112 0.0 V ABC transporter (Permease
HKLECMIN_00113 1.9e-124 V abc transporter atp-binding protein
HKLECMIN_00115 1.2e-43 yaaK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HKLECMIN_00116 2.6e-46
HKLECMIN_00117 0.0 ctpE P E1-E2 ATPase
HKLECMIN_00118 1.2e-59
HKLECMIN_00119 4.4e-40 pchB 2.5.1.19, 4.2.1.10, 4.2.99.21, 5.4.99.5 E Chorismate mutase type II
HKLECMIN_00120 2.4e-256 trpE 4.1.3.27 EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HKLECMIN_00121 2.3e-104 trpG 2.4.2.18, 2.6.1.85, 4.1.3.27 EH anthranilate
HKLECMIN_00122 3.9e-179 trpD 2.4.2.18, 4.1.3.27 F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HKLECMIN_00123 1.9e-133 trpC 4.1.1.48, 5.3.1.24 E Belongs to the TrpC family
HKLECMIN_00124 3.6e-100 trpF 4.1.1.48, 4.2.1.160, 4.2.1.20, 5.3.1.24 E belongs to the TrpF family
HKLECMIN_00125 3.2e-228 trpB 4.2.1.20, 5.3.1.24 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HKLECMIN_00126 1.3e-142 trpA 4.2.1.20 E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
HKLECMIN_00128 7.8e-163 EGP Major facilitator Superfamily
HKLECMIN_00129 1.8e-72 copY K negative regulation of transcription, DNA-templated
HKLECMIN_00130 0.0 copA 3.6.3.54 P P-type ATPase
HKLECMIN_00131 2.7e-31 copZ 2.7.7.77 P Heavy metal-associated domain protein
HKLECMIN_00132 3.5e-191 ddl 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
HKLECMIN_00133 6.6e-114 papP P ABC transporter (Permease
HKLECMIN_00134 4.6e-107 P ABC transporter (Permease
HKLECMIN_00135 1.7e-134 glnQ 3.6.3.21 E abc transporter atp-binding protein
HKLECMIN_00136 3.3e-155 cjaA ET ABC transporter substrate-binding protein
HKLECMIN_00141 1.6e-255 murF 6.3.2.10 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
HKLECMIN_00142 1.8e-116 ywaF S Integral membrane protein (intg_mem_TP0381)
HKLECMIN_00143 2.3e-300 prfC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HKLECMIN_00144 1.4e-96 thiT S Thiamine transporter
HKLECMIN_00145 9.6e-62 yjqA S Bacterial PH domain
HKLECMIN_00146 3.1e-151 corA P CorA-like protein
HKLECMIN_00147 2.2e-245 cshA 3.6.4.13 JKL DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
HKLECMIN_00148 1.5e-40 yazA L endonuclease containing a URI domain
HKLECMIN_00149 1.6e-140 yabB 2.1.1.223 L Methyltransferase
HKLECMIN_00150 3.4e-145 nodB3 G Polysaccharide deacetylase
HKLECMIN_00151 1.3e-142 plsC 2.3.1.51 I Acyltransferase
HKLECMIN_00152 4.3e-92 comEA L COG1555 DNA uptake protein and related DNA-binding proteins
HKLECMIN_00153 0.0 comEC S Competence protein ComEC
HKLECMIN_00154 5.5e-231 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HKLECMIN_00155 2.8e-99 XK27_07830 2.3.1.128 J Acetyltransferase GNAT Family
HKLECMIN_00156 3e-232 ytoI K transcriptional regulator containing CBS domains
HKLECMIN_00157 1.1e-166 map 3.4.11.18 E Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed
HKLECMIN_00158 2.8e-163 rbn E Belongs to the UPF0761 family
HKLECMIN_00159 1.7e-85 ccl S cog cog4708
HKLECMIN_00160 0.0 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HKLECMIN_00161 3.8e-182 yegS 2.7.1.107 I Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
HKLECMIN_00163 2.7e-172 yfjR K regulation of single-species biofilm formation
HKLECMIN_00165 3.9e-68 S QueT transporter
HKLECMIN_00166 1.4e-158 xth 3.1.11.2 L exodeoxyribonuclease III
HKLECMIN_00168 4.3e-197 XK27_00915 C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKLECMIN_00169 1.3e-17 yjdB S Domain of unknown function (DUF4767)
HKLECMIN_00170 4.3e-166 tehB 2.1.1.265 PQ tellurite resistance protein tehb
HKLECMIN_00171 9.6e-162 O protein import
HKLECMIN_00172 2.6e-124 agrA KT phosphorelay signal transduction system
HKLECMIN_00173 1.8e-200 2.7.13.3 T protein histidine kinase activity
HKLECMIN_00175 2.4e-43 rpsP J Belongs to the bacterial ribosomal protein bS16 family
HKLECMIN_00176 1.5e-36 ylqC L Belongs to the UPF0109 family
HKLECMIN_00177 4.3e-236 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
HKLECMIN_00178 0.0 ydaO E amino acid
HKLECMIN_00179 7.7e-100 folE 3.5.4.16 F gtp cyclohydrolase
HKLECMIN_00180 3.8e-145 folP 2.5.1.15, 2.7.6.3 H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HKLECMIN_00181 1.4e-294 amy 3.2.1.1 GH13 G Belongs to the glycosyl hydrolase 13 family
HKLECMIN_00182 1.3e-60 folB 1.13.11.81, 2.5.1.15, 2.7.6.3, 4.1.2.25, 5.1.99.8 H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HKLECMIN_00183 8.2e-82 folK 2.7.6.3, 4.1.2.25 H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HKLECMIN_00184 3.1e-167 murB 1.3.1.98 M cell wall formation
HKLECMIN_00185 5.2e-212 potA 3.6.3.30, 3.6.3.31 P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
HKLECMIN_00186 1.8e-139 potB P ABC-type spermidine putrescine transport system, permease component I
HKLECMIN_00187 2.3e-131 potC P ABC-type spermidine putrescine transport system, permease component II
HKLECMIN_00188 5.7e-205 potD P spermidine putrescine ABC transporter
HKLECMIN_00189 1.9e-145 XK27_08050 O HflC and HflK could regulate a protease
HKLECMIN_00190 1.8e-71 gloA 4.4.1.5 E Lactoylglutathione lyase
HKLECMIN_00191 2e-158 GK ROK family
HKLECMIN_00192 3e-209 serC 2.6.1.52 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HKLECMIN_00193 1.9e-103 wecD M Acetyltransferase (GNAT) domain
HKLECMIN_00194 1e-218 serA 1.1.1.399, 1.1.1.95 EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HKLECMIN_00195 2.1e-67 ogt 2.1.1.63, 3.2.2.20 L methylated-DNA-[protein]-cysteine S-methyltransferase activity
HKLECMIN_00197 3.5e-56 lrgA S Effector of murein hydrolase LrgA
HKLECMIN_00198 3.2e-116 lrgB M Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like proteins CidA and or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses
HKLECMIN_00199 1.8e-93 3.1.3.18 S IA, variant 1
HKLECMIN_00200 0.0 gyrB 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HKLECMIN_00201 6.4e-299 ezrA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HKLECMIN_00202 1.3e-111 serB 3.1.3.3 E phosphoserine phosphatase
HKLECMIN_00203 8.5e-08 N PFAM Uncharacterised protein family UPF0150
HKLECMIN_00204 5.2e-151 EG Permeases of the drug metabolite transporter (DMT) superfamily
HKLECMIN_00206 1.7e-60 ycaO O OsmC-like protein
HKLECMIN_00207 1.9e-62 paaI Q protein possibly involved in aromatic compounds catabolism
HKLECMIN_00208 5.7e-10 O ADP-ribosylglycohydrolase
HKLECMIN_00209 1.3e-131 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
HKLECMIN_00211 6.7e-248 obg S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HKLECMIN_00212 1.7e-17 XK27_00735
HKLECMIN_00213 1.6e-134 glnQ 3.6.3.21 E abc transporter atp-binding protein
HKLECMIN_00214 0.0 glnP P ABC-type amino acid transport signal transduction systems periplasmic component domain
HKLECMIN_00215 1.2e-161 S CAAX amino terminal protease family protein
HKLECMIN_00217 0.0 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
HKLECMIN_00218 1.1e-80 mutT 3.6.1.55 F Nudix family
HKLECMIN_00219 3.2e-139 ET ABC transporter
HKLECMIN_00220 9.4e-136 ET Belongs to the bacterial solute-binding protein 3 family
HKLECMIN_00221 5.6e-211 arcT 2.6.1.1 E Aminotransferase
HKLECMIN_00222 7.9e-135 gltS ET Belongs to the bacterial solute-binding protein 3 family
HKLECMIN_00223 3.2e-20 rpsU J Belongs to the bacterial ribosomal protein bS21 family
HKLECMIN_00224 8.4e-50 mscL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
HKLECMIN_00225 0.0 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
HKLECMIN_00226 4e-201 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
HKLECMIN_00227 3.4e-55 yitW K metal-sulfur cluster biosynthetic enzyme
HKLECMIN_00228 6.1e-171 yfdH GT2 M COG0463, glycosyltransferases involved in cell wall biogenesis
HKLECMIN_00229 3.8e-159 rfbD 1.1.1.133, 5.1.3.13 M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
HKLECMIN_00230 1.9e-124 ycbB S Glycosyl transferase family 2
HKLECMIN_00231 5.3e-48 XK27_09090 S Uncharacterized conserved protein (DUF2304)
HKLECMIN_00232 1.1e-215 amrA S polysaccharide biosynthetic process
HKLECMIN_00233 5.6e-178 tagF 2.7.8.12 M Glycosyl transferase, family 2
HKLECMIN_00234 1.1e-140 S Predicted membrane protein (DUF2142)
HKLECMIN_00235 1.5e-214 rgpA GT4 M Domain of unknown function (DUF1972)
HKLECMIN_00236 1.2e-174 rgpB GT2 M Glycosyltransferase, group 2 family protein
HKLECMIN_00237 5.2e-142 rgpC GM Transport permease protein
HKLECMIN_00238 1.8e-223 rgpD 3.6.3.38 P Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system
HKLECMIN_00239 7.8e-183 rgpEc GT2 M Glycosyl transferase family 2
HKLECMIN_00240 0.0 rgpF M Rhamnan synthesis protein F
HKLECMIN_00241 1.2e-118 radC E Belongs to the UPF0758 family
HKLECMIN_00242 8.2e-128 puuD T peptidase C26
HKLECMIN_00243 8.1e-117 rex K Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HKLECMIN_00244 3.1e-59 XK27_04120 S Putative amino acid metabolism
HKLECMIN_00245 2.2e-207 iscS 2.8.1.7 E Cysteine desulfurase
HKLECMIN_00246 8.7e-176 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HKLECMIN_00247 2.4e-101 yjbK S Adenylate cyclase
HKLECMIN_00248 6.1e-120 yjbM 2.7.6.5 S Gtp pyrophosphokinase
HKLECMIN_00249 7.5e-152 nadK 2.7.1.23 H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HKLECMIN_00250 4.5e-171 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 J Responsible for synthesis of pseudouridine from uracil
HKLECMIN_00251 1.4e-176 pta 2.3.1.8, 3.6.3.21 C phosphate acetyltransferase
HKLECMIN_00252 0.0 amiA E ABC transporter, substrate-binding protein, family 5
HKLECMIN_00253 0.0 amiA E ABC transporter, substrate-binding protein, family 5
HKLECMIN_00254 1.1e-273 amiC P ABC transporter (Permease
HKLECMIN_00255 3.8e-165 amiD P ABC transporter (Permease
HKLECMIN_00256 3e-201 oppD P Belongs to the ABC transporter superfamily
HKLECMIN_00257 3.1e-170 oppF P Belongs to the ABC transporter superfamily
HKLECMIN_00258 5.3e-115 V ATPase activity
HKLECMIN_00259 1.8e-119 skfE V abc transporter atp-binding protein
HKLECMIN_00260 5.6e-62 yvoA_1 K Transcriptional
HKLECMIN_00261 3.8e-145 supH S overlaps another CDS with the same product name
HKLECMIN_00262 1.8e-142 XK27_02985 S overlaps another CDS with the same product name
HKLECMIN_00263 3.3e-192 ftsY U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HKLECMIN_00264 8.8e-113 gmk 2.7.4.8 F Essential for recycling GMP and indirectly, cGMP
HKLECMIN_00265 3.6e-46 rpoZ 2.7.7.6 K DNA-directed 5'-3' RNA polymerase activity
HKLECMIN_00266 0.0 priA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HKLECMIN_00267 3.1e-170 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HKLECMIN_00268 2.7e-244 sun 2.1.1.176 J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HKLECMIN_00269 1.3e-134 stp 3.1.3.16 T phosphatase
HKLECMIN_00270 1.8e-294 prkC 2.7.11.1 KLT serine threonine protein kinase
HKLECMIN_00271 4.1e-104 kcsA P Ion transport protein
HKLECMIN_00272 1.7e-117 yvqF S Membrane
HKLECMIN_00273 1.9e-170 vraS 2.7.13.3 T Histidine kinase
HKLECMIN_00274 1.8e-113 vraR K Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HKLECMIN_00277 7.6e-94 rimM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HKLECMIN_00278 1.9e-135 trmD 2.1.1.228, 4.6.1.12 J Belongs to the RNA methyltransferase TrmD family
HKLECMIN_00279 3.3e-186 trxB1 1.18.1.2, 1.19.1.1 C Ferredoxin--NADP reductase
HKLECMIN_00280 0.0 ftsK D Belongs to the FtsK SpoIIIE SftA family
HKLECMIN_00281 0.0 pulA 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
HKLECMIN_00282 0.0 glgB 2.4.1.18, 3.2.1.141, 3.2.1.20 CBM48,GH13,GH31 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HKLECMIN_00283 5.8e-187 glgC 2.7.7.27 H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HKLECMIN_00284 6.8e-180 glgD 2.4.1.21, 2.7.7.27 GT5 G glucose-1-phosphate adenylyltransferase
HKLECMIN_00285 7e-283 glgA 2.4.1.21 GT5 G Synthesizes alpha-1,4-glucan chains using ADP-glucose
HKLECMIN_00286 0.0 glgP 2.4.1.1 GT35 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
HKLECMIN_00287 1.8e-101 2.3.1.128 K Acetyltransferase GNAT Family
HKLECMIN_00288 7e-281 S Protein of unknown function (DUF3114)
HKLECMIN_00290 0.0 gshF 6.3.2.2, 6.3.2.29, 6.3.2.30, 6.3.2.4 H Belongs to the glutamate--cysteine ligase type 1 family
HKLECMIN_00291 1.4e-296 V abc transporter atp-binding protein
HKLECMIN_00292 0.0 V abc transporter atp-binding protein
HKLECMIN_00293 9.7e-190 XK27_10075 S abc transporter atp-binding protein
HKLECMIN_00294 1.3e-10
HKLECMIN_00295 0.0 M domain protein
HKLECMIN_00297 3.3e-164 ppaC 3.6.1.1 C inorganic pyrophosphatase
HKLECMIN_00298 9.5e-104 S Domain of unknown function (DUF1803)
HKLECMIN_00299 7.8e-102 ygaC J Belongs to the UPF0374 family
HKLECMIN_00300 5.4e-136 recX 2.4.1.337 GT4 S Regulatory protein RecX
HKLECMIN_00301 2.6e-247 rumA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HKLECMIN_00302 8.8e-192 asnA 6.3.1.1 E aspartate--ammonia ligase
HKLECMIN_00303 3.1e-256 lysC 2.7.2.4 E Belongs to the aspartokinase family
HKLECMIN_00304 8.1e-114 S HAD hydrolase, family IA, variant 3
HKLECMIN_00305 3.1e-139 phaB 5.3.3.14, 5.3.3.18 I Belongs to the enoyl-CoA hydratase isomerase family
HKLECMIN_00306 5.2e-72 marR K Transcriptional regulator, MarR family
HKLECMIN_00307 1.1e-170 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HKLECMIN_00308 3.3e-30 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
HKLECMIN_00309 9.9e-172 fabK 1.3.1.9 S 2-Nitropropane dioxygenase
HKLECMIN_00310 3.3e-161 fabD 2.3.1.39 I Malonyl CoA-acyl carrier protein transacylase
HKLECMIN_00311 1.1e-125 IQ reductase
HKLECMIN_00312 1.3e-232 fabF 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
HKLECMIN_00313 1.6e-53 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
HKLECMIN_00314 1.5e-71 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
HKLECMIN_00315 5.4e-256 accC 6.3.4.14, 6.4.1.2 I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
HKLECMIN_00316 1.6e-157 accD 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HKLECMIN_00317 5.1e-139 accA 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
HKLECMIN_00318 4.7e-90 luxS 4.4.1.21 H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
HKLECMIN_00319 1.6e-206 rny D Endoribonuclease that initiates mRNA decay
HKLECMIN_00320 4e-112 fruR K transcriptional
HKLECMIN_00321 1.7e-165 pfkB 2.7.1.11, 2.7.1.56 H Belongs to the carbohydrate kinase PfkB family. LacC subfamily
HKLECMIN_00322 0.0 fruA 2.7.1.202 G phosphotransferase system
HKLECMIN_00323 2.3e-259 gor 1.8.1.7 C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HKLECMIN_00324 9.3e-231 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
HKLECMIN_00326 1.1e-209 iscS2 2.8.1.7 E Cysteine sulfinate desulfinase cysteine desulfurase and related enzymes
HKLECMIN_00327 2.8e-224 thiI 2.8.1.4 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HKLECMIN_00328 3.5e-293 gtf1 2.4.1.52 GT4 M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
HKLECMIN_00329 1.7e-254 gtf2 M A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1
HKLECMIN_00330 2.3e-93 2.3.1.128 K acetyltransferase
HKLECMIN_00331 4.5e-49 rplU J This protein binds to 23S rRNA in the presence of protein L20
HKLECMIN_00332 1.5e-46 rpmA J Belongs to the bacterial ribosomal protein bL27 family
HKLECMIN_00333 4.7e-131 ydaF_2 J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HKLECMIN_00334 2.1e-61 WQ51_03320 S cog cog4835
HKLECMIN_00335 2.5e-147 XK27_08360 S EDD domain protein, DegV family
HKLECMIN_00336 3.9e-139 dapB 1.17.1.8 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
HKLECMIN_00337 6.6e-218 cca 2.7.7.19, 2.7.7.72 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HKLECMIN_00338 0.0 yfmR S abc transporter atp-binding protein
HKLECMIN_00339 1.7e-26 U response to pH
HKLECMIN_00340 3.1e-128 3.6.1.13, 3.6.1.55 F AdP-ribose pyrophosphatase
HKLECMIN_00341 5.5e-211 nadD 2.7.1.22, 2.7.7.1, 2.7.7.18, 3.6.1.55 H adenylyltransferase
HKLECMIN_00342 1.5e-255 gdhA 1.4.1.4 E Belongs to the Glu Leu Phe Val dehydrogenases family
HKLECMIN_00343 1.1e-282 S Psort location CytoplasmicMembrane, score
HKLECMIN_00344 4.6e-70 def_1 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins
HKLECMIN_00345 8.8e-75 K DNA-binding transcription factor activity
HKLECMIN_00346 0.0 lmrA1 V abc transporter atp-binding protein
HKLECMIN_00347 0.0 lmrA2 V abc transporter atp-binding protein
HKLECMIN_00348 2.2e-111 K Acetyltransferase (GNAT) family
HKLECMIN_00349 5.7e-112 2.7.6.5 S Region found in RelA / SpoT proteins
HKLECMIN_00350 8.3e-117 T response regulator
HKLECMIN_00351 2.9e-213 sptS 2.7.13.3 T Histidine kinase
HKLECMIN_00352 1.7e-131 pyrH 2.7.4.22 F Catalyzes the reversible phosphorylation of UMP to UDP
HKLECMIN_00353 6.4e-91 frr J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
HKLECMIN_00354 3.5e-163 cvfB S Protein conserved in bacteria
HKLECMIN_00355 3.7e-34 yozE S Belongs to the UPF0346 family
HKLECMIN_00356 1e-123 sip M LysM domain protein
HKLECMIN_00357 2.6e-189 phoH T phosphate starvation-inducible protein PhoH
HKLECMIN_00361 0.0 metG 6.1.1.10, 6.1.1.20 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HKLECMIN_00362 1.2e-160 S reductase
HKLECMIN_00363 4.7e-168 K transcriptional regulator (lysR family)
HKLECMIN_00364 5.5e-106 S CAAX amino terminal protease family protein
HKLECMIN_00365 5.4e-278 S Glucan-binding protein C
HKLECMIN_00366 3.2e-170 coiA 3.6.4.12 S Competence protein
HKLECMIN_00367 0.0 pepF E oligoendopeptidase F
HKLECMIN_00368 9.4e-212 oxlT P COG0477 Permeases of the major facilitator superfamily
HKLECMIN_00369 2.1e-126 yrrM 2.1.1.104 S O-Methyltransferase
HKLECMIN_00370 5.1e-167 prsA 3.1.3.16, 5.2.1.8 O peptidyl-prolyl cis-trans isomerase activity
HKLECMIN_00371 3.9e-84 yxjI S LURP-one-related
HKLECMIN_00372 0.0 alaS 6.1.1.7 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HKLECMIN_00373 0.0 3.4.17.14, 3.5.1.28 M GBS Bsp-like repeat
HKLECMIN_00374 7.5e-135 agrA KT response regulator
HKLECMIN_00376 2.2e-07
HKLECMIN_00377 9e-133 agrA KT phosphorelay signal transduction system
HKLECMIN_00378 1.2e-228 2.7.13.3 T GHKL domain
HKLECMIN_00379 3.1e-164 L Integrase core domain protein
HKLECMIN_00380 7.3e-121 L Helix-turn-helix domain
HKLECMIN_00381 9.8e-85 L COG1943 Transposase and inactivated derivatives
HKLECMIN_00382 3.2e-211 3.5.1.28 NU GBS Bsp-like repeat
HKLECMIN_00383 5.1e-15
HKLECMIN_00384 0.0 vanY 3.4.17.14, 3.5.1.28 M D-alanyl-D-alanine carboxypeptidase
HKLECMIN_00385 4.4e-138 cnhA 3.5.1.3 S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
HKLECMIN_00386 3.3e-222 mtnE 2.6.1.83 E mutations do not affect methionine salvage in vivo however
HKLECMIN_00387 5e-182 argC 1.2.1.38 E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HKLECMIN_00388 4.6e-219 argJ 2.3.1.1, 2.3.1.35, 2.7.2.8 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HKLECMIN_00389 1.1e-122 argB 2.7.2.8 E Belongs to the acetylglutamate kinase family. ArgB subfamily
HKLECMIN_00390 9.4e-206 argD 2.6.1.11, 2.6.1.17 E acetylornithine aminotransferase
HKLECMIN_00391 7.4e-134 yxkH G deacetylase
HKLECMIN_00392 2e-236 hom 1.1.1.3, 2.7.2.4 E homoserine dehydrogenase
HKLECMIN_00393 1e-151 thrB 2.7.1.39 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
HKLECMIN_00394 9.7e-150 rarD S Transporter
HKLECMIN_00395 7.5e-16 T peptidase
HKLECMIN_00396 3e-14 coiA 3.6.4.12 S Competence protein
HKLECMIN_00397 7.5e-103 S COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HKLECMIN_00398 3.5e-97 2.3.1.128, 5.2.1.8 J Acetyltransferase (GNAT) domain
HKLECMIN_00399 4e-149 S the current gene model (or a revised gene model) may contain a frame shift
HKLECMIN_00400 0.0 valS 6.1.1.9 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
HKLECMIN_00401 6.1e-300
HKLECMIN_00402 7.2e-150 dam2 2.1.1.72 L DNA methyltransferase
HKLECMIN_00403 8.6e-47
HKLECMIN_00404 2.4e-16 atpE C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HKLECMIN_00405 3.4e-121 atpB C it plays a direct role in the translocation of protons across the membrane
HKLECMIN_00406 1.6e-77 atpF C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HKLECMIN_00407 8.7e-85 atpH C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HKLECMIN_00408 1e-279 atpA 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HKLECMIN_00409 6.2e-157 atpG C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HKLECMIN_00410 6.7e-262 atpD 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HKLECMIN_00411 2.6e-68 atpC C Produces ATP from ADP in the presence of a proton gradient across the membrane
HKLECMIN_00412 7.1e-204 rpsA 1.17.7.4 J ribosomal protein S1
HKLECMIN_00415 4.8e-16 S Protein of unknown function (DUF2969)
HKLECMIN_00416 5.3e-200 ilvE 2.6.1.42 E Aminotransferase
HKLECMIN_00417 0.0 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HKLECMIN_00418 1.1e-123 aadK G adenylyltransferase
HKLECMIN_00420 2.4e-13 S AAA ATPase domain
HKLECMIN_00421 3.5e-76 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HKLECMIN_00423 5.3e-52 K acetyltransferase
HKLECMIN_00424 8.1e-44
HKLECMIN_00426 0.0 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HKLECMIN_00427 2.3e-108 plsY 2.3.1.15, 3.5.1.104 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
HKLECMIN_00428 4.8e-13 L Helix-hairpin-helix DNA-binding motif class 1
HKLECMIN_00429 2.2e-30 S Domain of unknown function (DUF1912)
HKLECMIN_00430 8.8e-173 mmuM 1.5.1.20, 2.1.1.10 H Homocysteine
HKLECMIN_00431 5.8e-250 mmuP E amino acid
HKLECMIN_00432 3.9e-110 engB D Necessary for normal cell division and for the maintenance of normal septation
HKLECMIN_00433 2.6e-225 clpX O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HKLECMIN_00434 9.7e-22
HKLECMIN_00435 3.8e-90 folA 1.5.1.3, 1.5.1.47, 2.1.1.45, 3.5.4.12 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HKLECMIN_00436 1.1e-166 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HKLECMIN_00437 7.4e-214 mvaS 2.3.3.10 I synthase
HKLECMIN_00438 1.5e-223 mvaA 1.1.1.34, 1.1.1.88, 2.3.1.9 C Belongs to the HMG-CoA reductase family
HKLECMIN_00439 5e-78 K hmm pf08876
HKLECMIN_00440 1.2e-118 yqfA K protein, Hemolysin III
HKLECMIN_00441 6.7e-198 S Protein of unknown function (DUF3114)
HKLECMIN_00442 1.4e-162 S hydrolases or acyltransferases (alpha beta hydrolase superfamily)
HKLECMIN_00443 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HKLECMIN_00445 2.6e-247 mgs 2.4.1.337 GT4 M Glycosyltransferase, group 1 family protein
HKLECMIN_00446 5.2e-192 dgs 2.4.1.208 GT4 M Glycosyltransferase, group 1 family protein
HKLECMIN_00447 0.0 U protein secretion
HKLECMIN_00448 2.7e-115 mtnN 3.2.2.9 E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HKLECMIN_00449 2.1e-23
HKLECMIN_00450 2.1e-94 nudF 3.6.1.13 L AdP-ribose pyrophosphatase
HKLECMIN_00451 2.1e-231 glmU 2.3.1.157, 2.7.7.23 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HKLECMIN_00452 0.0 mgtA 3.6.3.2 P COG0474 Cation transport ATPase
HKLECMIN_00453 2.6e-183 fni 1.1.1.88, 5.3.3.2 C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
HKLECMIN_00454 1e-171 mvaK2 2.7.1.36, 2.7.1.43, 2.7.4.2 I phosphomevalonate kinase
HKLECMIN_00455 5.8e-169 mvaD 4.1.1.33 I diphosphomevalonate decarboxylase
HKLECMIN_00456 3.8e-138 mvk 1.1.1.88, 2.3.3.10, 2.7.1.36 I mevalonate kinase
HKLECMIN_00457 2.8e-246 merA 1.16.1.1 C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HKLECMIN_00458 5e-137 E Alpha beta hydrolase
HKLECMIN_00460 6.2e-194 ald 1.4.1.1 C Belongs to the AlaDH PNT family
HKLECMIN_00461 3e-10 puuD T peptidase C26
HKLECMIN_00462 3.8e-215 hipO 3.5.1.47 E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
HKLECMIN_00463 5.5e-127 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
HKLECMIN_00464 8.7e-114 S VIT family
HKLECMIN_00465 8.5e-134 deoD_1 2.4.2.3 F Phosphorylase superfamily
HKLECMIN_00466 4.7e-21
HKLECMIN_00467 1.6e-28 XK27_00085 K Transcriptional
HKLECMIN_00468 2.6e-196 yceA S Belongs to the UPF0176 family
HKLECMIN_00469 5.2e-122 nagB 3.1.1.31, 3.5.99.6 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
HKLECMIN_00470 1.9e-197 queA 2.4.99.17 J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HKLECMIN_00471 0.0 lmrA V abc transporter atp-binding protein
HKLECMIN_00472 0.0 mdlB V abc transporter atp-binding protein
HKLECMIN_00473 2.1e-45 rplL J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
HKLECMIN_00474 1.9e-78 rplJ J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HKLECMIN_00475 2.1e-211 V permease protein
HKLECMIN_00476 2e-121 macB V ABC transporter, ATP-binding protein
HKLECMIN_00477 1.2e-180 acrA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKLECMIN_00478 3.1e-128 2.1.1.223 S Putative SAM-dependent methyltransferase
HKLECMIN_00479 0.0 carB 6.3.5.5 F carbamoyl-phosphate synthetase ammonia chain
HKLECMIN_00480 9.3e-211 carA 6.3.5.5 F carbamoyl-phosphate synthetase glutamine chain
HKLECMIN_00481 1.3e-173 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
HKLECMIN_00482 1.4e-221 pyrP F uracil Permease
HKLECMIN_00483 4.8e-88 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HKLECMIN_00484 1.1e-161 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
HKLECMIN_00485 1.3e-76 lspA 3.4.23.36 MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HKLECMIN_00486 1.2e-166 fhuR K transcriptional regulator (lysR family)
HKLECMIN_00488 4.5e-95
HKLECMIN_00489 1.8e-56 V ABC-2 type transporter
HKLECMIN_00490 6.3e-157 V AAA domain, putative AbiEii toxin, Type IV TA system
HKLECMIN_00494 2.1e-140 ppiA 5.2.1.8 O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HKLECMIN_00495 0.0 pts33BCA 2.7.1.201, 2.7.1.208, 2.7.1.211 G pts system
HKLECMIN_00496 8.3e-10 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HKLECMIN_00497 1.1e-253 cycA E permease
HKLECMIN_00498 1.7e-38 ynzC S UPF0291 protein
HKLECMIN_00499 0.0 glyS 6.1.1.14 J Glycyl-tRNA synthetase beta subunit
HKLECMIN_00500 3.7e-176 glyQ 6.1.1.14 J glycyl-tRNA synthetase alpha subunit
HKLECMIN_00501 9.7e-75 S membrane
HKLECMIN_00502 8.6e-20 S membrane
HKLECMIN_00503 3.4e-211 nagA 3.5.1.25 G Belongs to the metallo-dependent hydrolases superfamily. NagA family
HKLECMIN_00504 4.2e-292 nptA P COG1283 Na phosphate symporter
HKLECMIN_00505 3.2e-104 3.4.17.14, 3.5.1.28 NU amidase activity
HKLECMIN_00506 4.9e-80 S Bacterial inner membrane protein
HKLECMIN_00507 5.7e-144 XK27_04800 S Sucrose-6F-phosphate phosphohydrolase
HKLECMIN_00508 2.1e-104 mur1 3.4.17.14, 3.5.1.28 NU amidase activity
HKLECMIN_00509 1.9e-53 glnB K Belongs to the P(II) protein family
HKLECMIN_00510 4.6e-183 amt P Ammonium Transporter
HKLECMIN_00511 3.1e-34 amt P Ammonium Transporter
HKLECMIN_00512 1.7e-154 rsmI 2.1.1.198 H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HKLECMIN_00513 1.2e-54 yabA L Involved in initiation control of chromosome replication
HKLECMIN_00514 1.3e-129 yaaT S stage 0 sporulation protein
HKLECMIN_00515 2.1e-160 holB 2.7.7.7 L dna polymerase iii
HKLECMIN_00516 2.7e-109 tmk 2.7.4.9 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HKLECMIN_00518 0.0 tkt 2.2.1.1 G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HKLECMIN_00519 2.9e-134 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
HKLECMIN_00520 2.8e-224 tuf J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HKLECMIN_00521 7.1e-218 ftsW D Belongs to the SEDS family
HKLECMIN_00522 7.4e-80 hmpT S cog cog4720
HKLECMIN_00523 1.5e-135 thiD 2.7.1.35, 2.7.1.49, 2.7.4.7 H phosphomethylpyrimidine kinase
HKLECMIN_00524 1.1e-138 truA 5.4.99.12 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
HKLECMIN_00525 8e-189 dnaJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
HKLECMIN_00526 7.5e-104 thiJ-2 3.5.1.124 S DJ-1/PfpI family
HKLECMIN_00527 6e-303 dnaK O Heat shock 70 kDa protein
HKLECMIN_00528 8.2e-64 grpE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HKLECMIN_00529 9.2e-184 hrcA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
HKLECMIN_00530 7.9e-100 acmA 3.2.1.17, 3.4.17.14, 3.5.1.28 NU Muramidase (Flagellum-specific)
HKLECMIN_00531 1.8e-139 vanY 3.4.17.14 M D-alanyl-D-alanine carboxypeptidase
HKLECMIN_00532 2.8e-131 ais G Phosphoglycerate mutase
HKLECMIN_00533 6.6e-243 XK27_08635 S UPF0210 protein
HKLECMIN_00534 6.1e-39 gcvR T UPF0237 protein
HKLECMIN_00535 5.7e-233 capA M Bacterial capsule synthesis protein
HKLECMIN_00536 4.6e-149 srtB 3.4.22.70 S Sortase family
HKLECMIN_00538 1.5e-29 K Helix-turn-helix domain
HKLECMIN_00539 7.6e-18
HKLECMIN_00540 2.5e-104 yiiE S protein homotetramerization
HKLECMIN_00541 1.2e-64 rpsI J Belongs to the universal ribosomal protein uS9 family
HKLECMIN_00542 2e-79 rplM J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HKLECMIN_00543 5.1e-22 K Transcriptional
HKLECMIN_00545 1.2e-152 degV S DegV family
HKLECMIN_00546 6e-91 yacP S RNA-binding protein containing a PIN domain
HKLECMIN_00547 3.7e-134 trmH 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HKLECMIN_00549 2.7e-67 mrnC J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HKLECMIN_00550 4e-256 cysS 6.1.1.16, 6.3.1.13 J Belongs to the class-I aminoacyl-tRNA synthetase family
HKLECMIN_00552 3.3e-112 cysE 2.3.1.30 E serine acetyltransferase
HKLECMIN_00553 2.1e-140 S SseB protein N-terminal domain
HKLECMIN_00554 0.0 pnp 2.7.7.8 J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
HKLECMIN_00555 2.6e-225 dacA 3.4.16.4 M Belongs to the peptidase S11 family
HKLECMIN_00556 2.2e-227 dacA 3.4.16.4 M Belongs to the peptidase S11 family
HKLECMIN_00557 0.0 clpC O Belongs to the ClpA ClpB family
HKLECMIN_00558 1.8e-75 ctsR K Belongs to the CtsR family
HKLECMIN_00559 1.6e-82 S Putative small multi-drug export protein
HKLECMIN_00560 1e-182 tsf J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HKLECMIN_00561 7.4e-138 rpsB J Belongs to the universal ribosomal protein uS2 family
HKLECMIN_00562 3.2e-106 ahpC 1.11.1.15 O alkyl hydroperoxide reductase
HKLECMIN_00563 6.6e-287 ahpF O alkyl hydroperoxide reductase
HKLECMIN_00565 3.2e-95 S reductase
HKLECMIN_00566 2.6e-71 badR K Transcriptional regulator, marr family
HKLECMIN_00567 5.5e-36 XK27_02060 S Transglycosylase associated protein
HKLECMIN_00568 6.6e-237 pepS E COG2309 Leucyl aminopeptidase (aminopeptidase T)
HKLECMIN_00569 0.0 polC 2.7.7.7 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HKLECMIN_00570 3.6e-49 qacC P COG2076 Membrane transporters of cations and cationic drugs
HKLECMIN_00571 1e-75 K Transcriptional
HKLECMIN_00572 7.2e-75
HKLECMIN_00573 7e-228 L Replication initiation factor
HKLECMIN_00574 2e-67
HKLECMIN_00575 3.5e-28 S Domain of unknown function (DUF3173)
HKLECMIN_00576 5.3e-209 L Belongs to the 'phage' integrase family
HKLECMIN_00581 1.9e-07
HKLECMIN_00585 6.6e-92 mreC M Involved in formation and maintenance of cell shape
HKLECMIN_00586 6.1e-83 mreD M rod shape-determining protein MreD
HKLECMIN_00587 5.4e-84 usp 3.5.1.28 CBM50 S CHAP domain
HKLECMIN_00588 9.5e-175 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HKLECMIN_00589 9.4e-217 araT 2.6.1.1 E Aminotransferase
HKLECMIN_00590 1e-139 recO L Involved in DNA repair and RecF pathway recombination
HKLECMIN_00591 9.2e-184 plsX 2.3.1.15 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
HKLECMIN_00592 2.4e-29 acpP1 IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
HKLECMIN_00593 8.9e-130 purC 4.1.1.21, 4.3.2.2, 6.3.2.6 F Belongs to the SAICAR synthetase family
HKLECMIN_00594 0.0 purL 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HKLECMIN_00595 6.4e-276 purF 2.4.2.14 F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HKLECMIN_00596 5.5e-189 purM 6.3.3.1, 6.3.4.13 F Phosphoribosylformylglycinamidine cyclo-ligase
HKLECMIN_00597 2.4e-98 purN 2.1.2.2 F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HKLECMIN_00598 2.1e-293 purH 2.1.2.3, 3.5.4.10 F Bifunctional purine biosynthesis protein PurH
HKLECMIN_00599 1.3e-156 S CHAP domain
HKLECMIN_00600 9.7e-236 purD 6.3.4.13 F Belongs to the GARS family
HKLECMIN_00601 4.5e-80 purE 5.4.99.18 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HKLECMIN_00602 7.8e-197 purK 6.3.4.18 F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HKLECMIN_00603 5.5e-51 S FRG
HKLECMIN_00604 8.1e-32
HKLECMIN_00605 1e-70
HKLECMIN_00606 2.6e-244 purB 4.3.2.2 F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HKLECMIN_00607 0.0 argS 6.1.1.19 J Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
HKLECMIN_00608 3.1e-69 argR K Regulates arginine biosynthesis genes
HKLECMIN_00609 1.1e-56 ymcA 3.6.3.21 S Belongs to the UPF0342 family
HKLECMIN_00610 0.0 mutS L that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HKLECMIN_00611 3.9e-78 S Protein of unknown function (DUF3021)
HKLECMIN_00612 1.6e-68 K LytTr DNA-binding domain
HKLECMIN_00614 0.0 mutL L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HKLECMIN_00616 3e-102 ruvA 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
HKLECMIN_00617 2.3e-104 tag 3.2.2.20 L 3-methyladenine DNA glycosylase
HKLECMIN_00618 8.8e-229 cinA 3.5.1.42 S Belongs to the CinA family
HKLECMIN_00619 1e-204 recA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HKLECMIN_00620 3.9e-66 spxA_2 1.20.4.1 P Belongs to the ArsC family
HKLECMIN_00621 0.0 uup S abc transporter atp-binding protein
HKLECMIN_00622 3.1e-113 udk 2.7.1.48 F Cytidine monophosphokinase
HKLECMIN_00623 3e-177 yfmL 3.6.4.13 L DEAD DEAH box helicase
HKLECMIN_00624 3.8e-226 XK27_05680 6.3.2.2, 6.3.2.4 M carbamoylphosphate synthase large subunit
HKLECMIN_00625 2.7e-153 XK27_05675 S Esterase
HKLECMIN_00626 6.1e-162 XK27_05670 S Putative esterase
HKLECMIN_00627 6.6e-265 gapN 1.2.1.9 C Belongs to the aldehyde dehydrogenase family
HKLECMIN_00629 7.4e-138 glnQ 3.6.3.21 E abc transporter atp-binding protein
HKLECMIN_00630 1.9e-59 tcyB_2 P ABC transporter (permease)
HKLECMIN_00631 1.6e-94 hpf J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HKLECMIN_00632 1.3e-82 comFC K competence protein
HKLECMIN_00633 1.8e-248 comFA L Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HKLECMIN_00634 3.8e-108 yvyE 3.4.13.9 S YigZ family
HKLECMIN_00635 6.3e-168 cysK 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
HKLECMIN_00636 1.6e-112 acuB S CBS domain
HKLECMIN_00637 5.6e-124 livF E COG0410 ABC-type branched-chain amino acid transport systems, ATPase component
HKLECMIN_00638 1.1e-136 livG E COG0411 ABC-type branched-chain amino acid transport systems, ATPase component
HKLECMIN_00639 4.9e-139 livM E Belongs to the binding-protein-dependent transport system permease family
HKLECMIN_00640 1.2e-144 livH E Belongs to the binding-protein-dependent transport system permease family
HKLECMIN_00641 5.3e-212 livJ E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component
HKLECMIN_00642 2.7e-45 ylbG S UPF0298 protein
HKLECMIN_00643 2.1e-68 ylbF S Belongs to the UPF0342 family
HKLECMIN_00644 3.7e-105 clpP 3.4.21.92 OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
HKLECMIN_00645 5.7e-112 upp 2.4.2.9 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HKLECMIN_00646 0.0 sacB 2.4.1.10, 2.4.1.9, 3.2.1.26 GH32,GH68 G Belongs to the glycosyl hydrolase 68 family
HKLECMIN_00647 0.0 3.2.1.26, 3.2.1.65 GH32 G Belongs to the glycosyl hydrolase 32 family
HKLECMIN_00648 2.3e-223 malY 4.4.1.8 E COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
HKLECMIN_00649 1.1e-200 metB 2.5.1.48, 4.4.1.8 E cystathionine
HKLECMIN_00650 0.0 pacL 3.6.3.8, 3.6.3.9 P cation transport ATPase
HKLECMIN_00651 1.9e-281 ytgP S Membrane protein involved in the export of O-antigen and teichoic acid
HKLECMIN_00652 2e-269 murE 6.3.2.13, 6.3.2.7 M to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HKLECMIN_00653 1.2e-97 yvdD 3.2.2.10 S Belongs to the LOG family
HKLECMIN_00654 8.6e-57 rbfA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HKLECMIN_00655 0.0 infB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HKLECMIN_00656 8e-42 ylxQ J ribosomal protein
HKLECMIN_00657 1e-47 ylxR K Nucleic-acid-binding protein implicated in transcription termination
HKLECMIN_00658 2.4e-196 nusA K Participates in both transcription termination and antitermination
HKLECMIN_00659 2.3e-81 rimP S Required for maturation of 30S ribosomal subunits
HKLECMIN_00660 1.8e-181 brpA K Transcriptional
HKLECMIN_00661 8.7e-90 XK27_05885 2.3.1.82 M phosphinothricin N-acetyltransferase activity
HKLECMIN_00662 9.4e-77 ydiB 2.7.1.221, 5.1.1.1 M ATPase or kinase
HKLECMIN_00663 1.6e-247 pbuO S permease
HKLECMIN_00664 3.5e-154 yitU 3.1.3.104 S hydrolases of the HAD superfamily
HKLECMIN_00665 3.5e-137 XK27_00940 1.2.1.70, 3.5.1.9 S Metal-dependent hydrolase
HKLECMIN_00666 6.2e-169 manL 2.7.1.191 G pts system
HKLECMIN_00667 3.4e-133 manY G pts system
HKLECMIN_00668 2e-161 manN G PTS system mannose fructose sorbose family IID component
HKLECMIN_00669 1e-66 manO S Protein conserved in bacteria
HKLECMIN_00670 6.3e-174 manL 2.7.1.191 G pts system
HKLECMIN_00671 2e-117 manM G pts system
HKLECMIN_00672 3.3e-169 manN G PTS system mannose fructose sorbose family IID component
HKLECMIN_00673 2.5e-62 manO S protein conserved in bacteria
HKLECMIN_00674 6.8e-229 serS 6.1.1.11 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HKLECMIN_00675 5.5e-107
HKLECMIN_00676 2.6e-247 der 1.1.1.399, 1.1.1.95 S GTPase that plays an essential role in the late steps of ribosome biogenesis
HKLECMIN_00677 2.9e-165 dnaI L Primosomal protein DnaI
HKLECMIN_00678 1.1e-214 dnaB L Replication initiation and membrane attachment
HKLECMIN_00679 3e-81 nrdR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HKLECMIN_00680 4.6e-280 T PhoQ Sensor
HKLECMIN_00681 7.9e-123 T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HKLECMIN_00682 6.2e-91 yceD K metal-binding, possibly nucleic acid-binding protein
HKLECMIN_00683 2.1e-126 rsmG 2.1.1.170 J Ribosomal RNA small subunit methyltransferase G
HKLECMIN_00684 8.3e-233 P COG0168 Trk-type K transport systems, membrane components
HKLECMIN_00685 3e-119 ktrA P COG0569 K transport systems, NAD-binding component
HKLECMIN_00686 4.5e-149 cbiQ P cobalt transport
HKLECMIN_00687 4.6e-311 ykoD P abc transporter atp-binding protein
HKLECMIN_00688 2e-92 S UPF0397 protein
HKLECMIN_00689 2.5e-155 salL 2.5.1.63, 2.5.1.94 S S-adenosyl-l-methionine hydroxide adenosyltransferase
HKLECMIN_00690 6.1e-211 sstT E Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HKLECMIN_00691 8e-99 metI P ABC transporter (Permease
HKLECMIN_00692 6.4e-188 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HKLECMIN_00693 7.7e-263 dapE 3.5.1.18 E COG0624, acetylornithine deacetylase succinyl-diaminopimelate desuccinylase and related deacylases
HKLECMIN_00694 1.9e-164 metQ M Belongs to the NlpA lipoprotein family
HKLECMIN_00695 1.8e-137 ET ABC transporter substrate-binding protein
HKLECMIN_00696 1.8e-130 cbiO P ABC transporter
HKLECMIN_00697 3.2e-136 P cobalt transport protein
HKLECMIN_00698 1.3e-176 cbiM P biosynthesis protein CbiM
HKLECMIN_00699 5.2e-161 ureD O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
HKLECMIN_00700 4.7e-111 ureG KO Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HKLECMIN_00701 5.3e-130 ureF O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
HKLECMIN_00702 6.6e-78 ureE O enzyme active site formation
HKLECMIN_00703 0.0 ureC 3.5.1.5 E Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family
HKLECMIN_00704 7.8e-54 ureB 3.5.1.5 E Belongs to the urease beta subunit family
HKLECMIN_00705 7.6e-46 ureA 3.5.1.5 E Belongs to the urease gamma subunit family
HKLECMIN_00706 2.6e-94 ureI S AmiS/UreI family transporter
HKLECMIN_00707 6.9e-243 S Domain of unknown function (DUF4173)
HKLECMIN_00708 1.3e-54 yhaI L Membrane
HKLECMIN_00709 0.0 comA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
HKLECMIN_00710 1e-154 K sequence-specific DNA binding
HKLECMIN_00711 4.7e-101 bcrC 3.6.1.27 I Membrane-associated phospholipid phosphatase
HKLECMIN_00712 2.1e-89 ribU U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HKLECMIN_00713 2.4e-92 trmL 2.1.1.207 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
HKLECMIN_00714 2.2e-246 trkA P Potassium transporter peripheral membrane component
HKLECMIN_00715 2.8e-255 trkH P Cation transport protein
HKLECMIN_00716 1.4e-13 yidD M Could be involved in insertion of integral membrane proteins into the membrane
HKLECMIN_00717 3.4e-132 rluB 5.4.99.19, 5.4.99.21, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
HKLECMIN_00718 1.3e-94 scpB D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HKLECMIN_00719 1.4e-122 scpA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HKLECMIN_00720 3.6e-132 xerD L tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site
HKLECMIN_00721 8.3e-87 ykuL S CBS domain
HKLECMIN_00722 1.7e-98 XK27_09740 S Phosphoesterase
HKLECMIN_00723 1.3e-184 rdgB 3.6.1.66, 5.1.1.3 F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HKLECMIN_00724 1.5e-149 murI 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
HKLECMIN_00725 1.6e-36 yneF S UPF0154 protein
HKLECMIN_00726 1.8e-90 K transcriptional regulator
HKLECMIN_00727 6.2e-243 lysA 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
HKLECMIN_00728 4.2e-12 ycdA S Domain of unknown function (DUF4352)
HKLECMIN_00729 2.1e-99 ybhL S Belongs to the BI1 family
HKLECMIN_00730 7.3e-94 XK27_09705 6.1.1.14 S HD superfamily hydrolase
HKLECMIN_00731 5.6e-127 spoU 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HKLECMIN_00732 9.2e-46 acyP 3.6.1.7 C Belongs to the acylphosphatase family
HKLECMIN_00733 3.4e-166 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HKLECMIN_00734 1.2e-77 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
HKLECMIN_00735 1.3e-300 mltG ADL Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HKLECMIN_00736 2.2e-87 XK27_09675 K histone acetyltransferase HPA2 and related acetyltransferases
HKLECMIN_00737 1.2e-255 mpl 6.3.2.4, 6.3.2.45, 6.3.2.8 M Belongs to the MurCDEF family
HKLECMIN_00738 9.6e-23
HKLECMIN_00739 0.0 snf 2.7.11.1 L Superfamily II DNA RNA helicases, SNF2 family'
HKLECMIN_00740 3.7e-274 mapZ D Early cell division protein that marks the future cell division site and supports proper FtsZ ring positioning
HKLECMIN_00741 2.8e-221 rlmL 2.1.1.173, 2.1.1.264 L Belongs to the methyltransferase superfamily
HKLECMIN_00742 1.6e-49 gpsB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
HKLECMIN_00743 5.8e-94 ypsA S Belongs to the UPF0398 family
HKLECMIN_00744 9.6e-109 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
HKLECMIN_00745 0.0 ponA 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
HKLECMIN_00746 2.6e-255 pepC 3.4.22.40 E aminopeptidase
HKLECMIN_00747 1.7e-73 yhaI S Protein of unknown function (DUF805)
HKLECMIN_00748 3.8e-148 nadE 6.3.1.5 H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
HKLECMIN_00749 1.8e-265 pncB 6.3.4.21 H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HKLECMIN_00750 3.9e-216 macB_2 V FtsX-like permease family
HKLECMIN_00751 2.1e-120 yhcA V abc transporter atp-binding protein
HKLECMIN_00752 2e-121 mta K Transcriptional
HKLECMIN_00753 5.2e-32 S Protein of unknown function (DUF3021)
HKLECMIN_00754 9e-75 K COG3279 Response regulator of the LytR AlgR family
HKLECMIN_00755 1.3e-124 cylB V ABC-2 type transporter
HKLECMIN_00756 6.6e-151 cylA V abc transporter atp-binding protein
HKLECMIN_00757 2.3e-24 yjdF S Protein of unknown function (DUF2992)
HKLECMIN_00758 0.0 leuS 6.1.1.4 J Belongs to the class-I aminoacyl-tRNA synthetase family
HKLECMIN_00759 1.3e-134 glcR K transcriptional regulator (DeoR family)
HKLECMIN_00760 7.3e-144 cof S Sucrose-6F-phosphate phosphohydrolase
HKLECMIN_00761 7.3e-69 3.1.3.27, 3.1.3.4, 3.1.3.81, 3.6.1.27 I phosphatidate phosphatase activity
HKLECMIN_00762 8.4e-96 nusG K Participates in transcription elongation, termination and antitermination
HKLECMIN_00763 2.8e-24 secE U Belongs to the SecE SEC61-gamma family
HKLECMIN_00764 6.2e-20 rpmG J Belongs to the bacterial ribosomal protein bL33 family
HKLECMIN_00765 0.0 pbp2A 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
HKLECMIN_00766 1.4e-164 rluA 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
HKLECMIN_00767 7.6e-55 S TM2 domain
HKLECMIN_00768 1e-42
HKLECMIN_00770 1.5e-286 groL O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
HKLECMIN_00771 2.7e-40 groS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HKLECMIN_00772 1.4e-142 cmpC S abc transporter atp-binding protein
HKLECMIN_00773 0.0 WQ51_06230 S ABC transporter substrate binding protein
HKLECMIN_00774 0.0 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
HKLECMIN_00775 3.2e-231 rseP 3.4.21.107, 3.4.21.116 M zinc metalloprotease
HKLECMIN_00776 4.8e-140 cdsA 2.7.7.41 S Belongs to the CDS family
HKLECMIN_00777 5.3e-141 uppS 2.5.1.31 H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HKLECMIN_00778 7.7e-47 yajC U protein transport
HKLECMIN_00779 6.1e-126 yeeN K transcriptional regulatory protein
HKLECMIN_00780 3.6e-280 V ABC transporter
HKLECMIN_00781 1.4e-153 Z012_04635 K sequence-specific DNA binding
HKLECMIN_00782 8.2e-219 L the current gene model (or a revised gene model) may contain a frame shift
HKLECMIN_00783 9.8e-306 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
HKLECMIN_00784 1.1e-108 L Transposase IS116 IS110 IS902
HKLECMIN_00785 9.2e-59 L MULE transposase domain
HKLECMIN_00786 8.1e-16 tnp* L An automated process has identified a potential problem with this gene model
HKLECMIN_00787 4.2e-59 srlB 2.7.1.198 G sorbitol-specific, IIA component
HKLECMIN_00788 3.8e-179 srlE 2.7.1.198 G PTS sorbitol transporter subunit IIB
HKLECMIN_00789 1.1e-95 srlA G PTS system glucitol sorbitol-specific
HKLECMIN_00790 6.8e-84 gutM K phosphoenolpyruvate-dependent sugar phosphotransferase system
HKLECMIN_00791 0.0 srlM 2.7.1.202, 2.7.1.204 GKT Mga helix-turn-helix domain
HKLECMIN_00792 1.4e-142 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
HKLECMIN_00793 4.2e-253 pgi 5.3.1.9 G Belongs to the GPI family
HKLECMIN_00794 4.6e-154 rgfB 3.1.3.90 L Endonuclease/Exonuclease/phosphatase family
HKLECMIN_00795 0.0 ptsG 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G pts system
HKLECMIN_00796 5.5e-159 mleP2 S Transporter, auxin efflux carrier (AEC) family protein
HKLECMIN_00797 9.6e-128 adcB P ABC transporter (Permease
HKLECMIN_00798 5.4e-135 adcC 3.6.3.35 P ABC transporter, ATP-binding protein
HKLECMIN_00799 1e-70 adcR K transcriptional
HKLECMIN_00800 1.1e-181 dus J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HKLECMIN_00801 4.3e-158 hslO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HKLECMIN_00802 4.7e-26
HKLECMIN_00803 2.9e-273 sufB O assembly protein SufB
HKLECMIN_00804 9.4e-74 nifU C SUF system FeS assembly protein, NifU family
HKLECMIN_00805 8.8e-234 sufS 2.8.1.7, 4.4.1.16 E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HKLECMIN_00806 1.2e-233 sufD O assembly protein SufD
HKLECMIN_00807 1.7e-137 sufC O ABC-type transport system involved in Fe-S cluster assembly, ATPase component
HKLECMIN_00808 1.5e-182 tagO 2.7.8.33, 2.7.8.35 M transferase
HKLECMIN_00809 2.3e-123 mecA NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
HKLECMIN_00810 8.3e-18 S Protein of unknown function (DUF3021)
HKLECMIN_00811 4.5e-152 uppP 3.6.1.27 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
HKLECMIN_00812 4.3e-270 glnP P ABC transporter
HKLECMIN_00813 2.2e-123 glnQ E abc transporter atp-binding protein
HKLECMIN_00814 1.5e-174 D nuclear chromosome segregation
HKLECMIN_00815 8.1e-84 V VanZ like family
HKLECMIN_00816 9.2e-43 rpsO J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HKLECMIN_00817 4e-191 yhjX P Major Facilitator
HKLECMIN_00818 2.2e-111 fnr5 K Catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
HKLECMIN_00819 3.3e-112 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
HKLECMIN_00820 1.5e-236 ilvA 4.3.1.19 E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HKLECMIN_00821 0.0 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
HKLECMIN_00822 5.7e-74 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
HKLECMIN_00823 0.0 relA 2.7.6.5 KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HKLECMIN_00824 5.9e-82 nrdI F Belongs to the NrdI family
HKLECMIN_00825 0.0 cpdB 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
HKLECMIN_00826 1.3e-131 rsmE 2.1.1.193 J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
HKLECMIN_00827 2.6e-177 prmA J Ribosomal protein L11 methyltransferase
HKLECMIN_00828 3.5e-74 mutT3 3.6.1.13, 3.6.1.55 L NUDIX domain
HKLECMIN_00829 1.4e-83 XK27_03960 S Protein of unknown function (DUF3013)
HKLECMIN_00830 1.7e-309 pyrG 6.3.4.2 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
HKLECMIN_00831 1.3e-70 rpoE K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
HKLECMIN_00832 5.2e-229 tig D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
HKLECMIN_00833 3.1e-139 ykuT M mechanosensitive ion channel
HKLECMIN_00834 3.9e-87 sigH K DNA-templated transcription, initiation
HKLECMIN_00835 4e-43 S Sugar efflux transporter for intercellular exchange
HKLECMIN_00840 1.7e-34 gltJ P ABC transporter (Permease
HKLECMIN_00841 3.2e-36 gltJ P ABC transporter (Permease
HKLECMIN_00847 0.0 lepA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
HKLECMIN_00850 0.0 alsS 2.2.1.6 EH Belongs to the TPP enzyme family
HKLECMIN_00851 3e-133 budA 4.1.1.5 H Belongs to the alpha-acetolactate decarboxylase family
HKLECMIN_00852 2.1e-68 mgrA K Transcriptional regulator, MarR family
HKLECMIN_00853 3.7e-112 1.6.5.2 GM NmrA-like family
HKLECMIN_00854 1.6e-129 proV E abc transporter atp-binding protein
HKLECMIN_00855 5.9e-264 proWX P ABC transporter
HKLECMIN_00856 4.1e-110 magIII L Base excision DNA repair protein, HhH-GPD family
HKLECMIN_00857 0.0 V ABC transporter (Permease
HKLECMIN_00858 9.5e-124 V abc transporter atp-binding protein
HKLECMIN_00859 1.7e-91 tetR K transcriptional regulator
HKLECMIN_00860 2.7e-138 S Phenazine biosynthesis protein
HKLECMIN_00861 2.2e-92 2.7.7.65 T Psort location CytoplasmicMembrane, score
HKLECMIN_00862 1.7e-132 cbiQ P cobalt transport
HKLECMIN_00863 1e-156 P abc transporter atp-binding protein
HKLECMIN_00864 9.7e-149 cbiO2 P ABC transporter, ATP-binding protein
HKLECMIN_00865 1.2e-175 saeS 2.7.13.3 T ATPase histidine kinase DNA gyrase B HSP90 domain protein
HKLECMIN_00866 2e-126 K response regulator
HKLECMIN_00867 0.0 S Signal peptide protein, YSIRK family
HKLECMIN_00868 3.1e-73 L Transposase
HKLECMIN_00869 7.6e-47
HKLECMIN_00870 1.1e-70 S Protein of unknown function with HXXEE motif
HKLECMIN_00871 1.3e-97 K Transcriptional regulator, TetR family
HKLECMIN_00872 8.1e-160 czcD P cation diffusion facilitator family transporter
HKLECMIN_00873 2.1e-194 hemH 4.99.1.1, 4.99.1.9 H Catalyzes the ferrous insertion into protoporphyrin IX
HKLECMIN_00874 8.4e-185 adhB 1.1.1.1, 1.1.1.14 E Dehydrogenase
HKLECMIN_00875 7e-242 S the current gene model (or a revised gene model) may contain a frame shift
HKLECMIN_00876 2.5e-107 gph 3.1.3.18 S HAD hydrolase, family IA, variant 1
HKLECMIN_00877 0.0 V Type III restriction enzyme, res subunit
HKLECMIN_00878 2.2e-179 yclQ P ABC-type enterochelin transport system, periplasmic component
HKLECMIN_00879 1.1e-229 dinF V Mate efflux family protein
HKLECMIN_00880 8.4e-274 S Psort location CytoplasmicMembrane, score
HKLECMIN_00881 6.2e-307 FbpA K RNA-binding protein homologous to eukaryotic snRNP
HKLECMIN_00883 1.6e-135 S TraX protein
HKLECMIN_00884 3e-93 thiJ 2.7.11.1, 3.5.1.124 S DJ-1 family
HKLECMIN_00885 2.9e-145 pyrK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )
HKLECMIN_00886 1.5e-175 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
HKLECMIN_00887 2.7e-180 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HKLECMIN_00888 7.8e-52 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HKLECMIN_00889 1.7e-131 cas6 S Pfam:DUF2276
HKLECMIN_00890 0.0 csm1 S CRISPR-associated protein Csm1 family
HKLECMIN_00891 1.2e-61 csm2 L Pfam:DUF310
HKLECMIN_00892 7.6e-115 csm3 L RAMP superfamily
HKLECMIN_00893 3.5e-163 csm4 L CRISPR-associated RAMP protein, Csm4 family
HKLECMIN_00894 3.3e-200 csm5 L CRISPR-associated RAMP protein, Csm5 family
HKLECMIN_00895 9.5e-113 csm6 S Psort location Cytoplasmic, score
HKLECMIN_00896 1.1e-146 csm6 S Psort location Cytoplasmic, score
HKLECMIN_00897 7.7e-126 pyrF 4.1.1.23 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
HKLECMIN_00898 9.8e-112 pyrE 2.4.2.10, 4.1.1.23 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HKLECMIN_00899 1.3e-239 nylA 3.5.1.4 J Belongs to the amidase family
HKLECMIN_00900 1.8e-148 yckB ET Belongs to the bacterial solute-binding protein 3 family
HKLECMIN_00901 2.4e-81 yecS P ABC transporter (Permease
HKLECMIN_00902 0.0 sasH 3.1.3.5, 3.6.1.45 F Belongs to the 5'-nucleotidase family
HKLECMIN_00903 3e-176 bglC K Transcriptional regulator
HKLECMIN_00904 2.3e-243 mnmE S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HKLECMIN_00905 2.1e-241 agcS E (Alanine) symporter
HKLECMIN_00906 0.0 pcrA 3.6.4.12 L ATP-dependent DNA helicase
HKLECMIN_00907 4.3e-239 metY 2.5.1.49 E o-acetylhomoserine
HKLECMIN_00908 6.8e-136 S haloacid dehalogenase-like hydrolase
HKLECMIN_00909 8.5e-87 tpx 1.11.1.15 O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HKLECMIN_00910 1.8e-110 hsdS2 2.1.1.72 V Type I restriction modification DNA specificity domain
HKLECMIN_00911 6.1e-35 M1-755 P Hemerythrin HHE cation binding domain protein
HKLECMIN_00912 2.4e-240 XK27_04775 S hemerythrin HHE cation binding domain
HKLECMIN_00913 1.7e-148 truB 5.4.99.25 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HKLECMIN_00914 1.5e-169 ribF 2.7.1.26, 2.7.7.2 H Belongs to the ribF family
HKLECMIN_00915 3.6e-70 spxA 1.20.4.1 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
HKLECMIN_00916 1e-44 yktA S Belongs to the UPF0223 family
HKLECMIN_00917 5e-142 suhB 3.1.3.25 G Belongs to the inositol monophosphatase superfamily
HKLECMIN_00918 9.7e-247 rsmF 2.1.1.176, 2.1.1.178 J NOL1 NOP2 sun family protein
HKLECMIN_00919 2.6e-155 pstS P phosphate
HKLECMIN_00920 1.9e-156 pstC P probably responsible for the translocation of the substrate across the membrane
HKLECMIN_00921 1.5e-155 pstA P phosphate transport system permease
HKLECMIN_00922 4e-150 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
HKLECMIN_00923 1.3e-139 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
HKLECMIN_00924 3.2e-113 phoU P Plays a role in the regulation of phosphate uptake
HKLECMIN_00925 0.0 pepN 3.4.11.2 E aminopeptidase
HKLECMIN_00926 1.9e-192 xerS D Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division
HKLECMIN_00927 7.2e-186 lplA 6.3.1.20 H Lipoate-protein ligase
HKLECMIN_00928 1.5e-38
HKLECMIN_00929 0.0 glgP 2.4.1.1 GT35 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
HKLECMIN_00930 1.1e-299 malQ 2.4.1.25 GH77 G 4-alpha-glucanotransferase
HKLECMIN_00931 2.1e-156 malR K Transcriptional regulator
HKLECMIN_00932 8.7e-229 malX G ABC transporter
HKLECMIN_00933 1.3e-249 malF P ABC transporter (Permease
HKLECMIN_00934 9.8e-152 malG P ABC transporter (Permease
HKLECMIN_00935 4.7e-213 msmX P Belongs to the ABC transporter superfamily
HKLECMIN_00936 1.9e-23 tatA U protein secretion
HKLECMIN_00937 2.9e-123 tatC U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HKLECMIN_00938 3.7e-291 ywbL P COG0672 High-affinity Fe2 Pb2 permease
HKLECMIN_00939 1.8e-231 ycdB P peroxidase
HKLECMIN_00940 1.7e-138 ycdO P periplasmic lipoprotein involved in iron transport
HKLECMIN_00941 0.0 pulA 3.2.1.1, 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
HKLECMIN_00942 1e-108 lytC 3.4.17.14, 3.5.1.28 M N-acetylmuramoyl-L-alanine amidase
HKLECMIN_00943 1.4e-193 3.5.1.28 M N-Acetylmuramoyl-L-alanine amidase
HKLECMIN_00944 0.0 3.5.1.28 NU amidase activity
HKLECMIN_00945 0.0 lpdA 1.8.1.4 C Dehydrogenase
HKLECMIN_00946 5.8e-210 acoC 2.3.1.12 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
HKLECMIN_00947 6.4e-182 acoB 1.2.4.1, 1.2.4.4 C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
HKLECMIN_00948 8.6e-184 acoA 1.2.4.1, 1.2.4.4 C Dehydrogenase E1 component
HKLECMIN_00949 1.8e-202 hpk9 2.7.13.3 T protein histidine kinase activity
HKLECMIN_00950 1.6e-225 2.7.13.3 T protein histidine kinase activity
HKLECMIN_00951 0.0 S the current gene model (or a revised gene model) may contain a frame shift
HKLECMIN_00952 1e-232 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
HKLECMIN_00953 3.8e-119 ung 3.2.2.27 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HKLECMIN_00954 4.7e-216 yeaB K Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HKLECMIN_00955 1.4e-248 dacA1 3.4.16.4 M Belongs to the peptidase S11 family
HKLECMIN_00956 2.7e-183 dacA1 3.4.16.4 M Belongs to the peptidase S11 family
HKLECMIN_00957 7.4e-155 rssA S Phospholipase, patatin family
HKLECMIN_00958 4.8e-103 estA E Lysophospholipase L1 and related esterases
HKLECMIN_00959 1.4e-287 S unusual protein kinase
HKLECMIN_00960 6.4e-39 S granule-associated protein
HKLECMIN_00961 1.6e-287 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
HKLECMIN_00962 1.2e-195 S hmm pf01594
HKLECMIN_00963 3.8e-105 G Belongs to the phosphoglycerate mutase family
HKLECMIN_00964 2.8e-108 G Belongs to the phosphoglycerate mutase family
HKLECMIN_00965 5.6e-68 pgm G Belongs to the phosphoglycerate mutase family
HKLECMIN_00966 5.7e-24 pgm G Belongs to the phosphoglycerate mutase family
HKLECMIN_00967 6.3e-89 supH 3.1.3.102, 3.1.3.104 S Sucrose-6F-phosphate phosphohydrolase
HKLECMIN_00968 9.2e-26 supH 3.1.3.102, 3.1.3.104 S Sucrose-6F-phosphate phosphohydrolase
HKLECMIN_00970 3.8e-177 wbbI M transferase activity, transferring glycosyl groups
HKLECMIN_00971 1e-184 sacB GT2,GT4 M Stealth protein CR2, conserved region 2
HKLECMIN_00972 1.1e-214 glf 5.4.99.9 M UDP-galactopyranose mutase
HKLECMIN_00973 2.4e-243 epsU S Polysaccharide biosynthesis protein
HKLECMIN_00974 1.7e-122 cps3F
HKLECMIN_00975 2.9e-164 M Glycosyltransferase like family 2
HKLECMIN_00976 4e-165
HKLECMIN_00977 3.4e-120 Z012_10770 M Domain of unknown function (DUF1919)
HKLECMIN_00978 4.4e-211 wcoF M Glycosyltransferase, group 1 family protein
HKLECMIN_00979 2.6e-219 rgpAc GT4 M group 1 family protein
HKLECMIN_00980 1e-251 cpsE M Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
HKLECMIN_00981 5.9e-116 cpsD D COG0489 ATPases involved in chromosome partitioning
HKLECMIN_00982 1.2e-110 cps4C M biosynthesis protein
HKLECMIN_00983 1.4e-133 cpsB 3.1.3.48 GM Capsular polysaccharide biosynthesis protein
HKLECMIN_00984 1.5e-248 cps4A K Cell envelope-like function transcriptional attenuator common domain protein
HKLECMIN_00985 4.5e-129 deoD 2.4.2.1, 2.4.2.28 F purine nucleoside phosphorylase
HKLECMIN_00986 1.8e-133 yfeJ 6.3.5.2 F glutamine amidotransferase
HKLECMIN_00987 6.5e-176 clcA_2 P Chloride transporter, ClC family
HKLECMIN_00988 1.8e-53 S LemA family
HKLECMIN_00989 4.7e-143 punA 2.4.2.1 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HKLECMIN_00990 2.7e-86 S Protein of unknown function (DUF1697)
HKLECMIN_00991 8.7e-234 deoB 5.4.2.7 G Phosphotransfer between the C1 and C5 carbon atoms of pentose
HKLECMIN_00992 1.5e-121 rpiA 2.7.1.12, 2.7.1.15, 5.3.1.6 G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HKLECMIN_00993 5.6e-253 V Glucan-binding protein C
HKLECMIN_00994 1.5e-228 V Glucan-binding protein C
HKLECMIN_00995 1.1e-109 ung2 3.2.2.27 L Uracil-DNA glycosylase
HKLECMIN_00996 2.2e-273 pepV 3.5.1.18 E Dipeptidase
HKLECMIN_00997 4.9e-27 dmpI 5.3.2.6 G Belongs to the 4-oxalocrotonate tautomerase family
HKLECMIN_00998 1.2e-91 yybC
HKLECMIN_00999 2.6e-85 XK27_03610 K Gnat family
HKLECMIN_01000 1.5e-56 rplT J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HKLECMIN_01001 8.1e-28 rpmI J Belongs to the bacterial ribosomal protein bL35 family
HKLECMIN_01002 1e-85 infC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HKLECMIN_01003 3.6e-120 cmk 1.17.7.4, 2.5.1.19, 2.7.1.26, 2.7.4.25, 2.7.7.2, 6.3.2.1 F Belongs to the cytidylate kinase family. Type 1 subfamily
HKLECMIN_01004 9.4e-17 M LysM domain
HKLECMIN_01005 8.6e-87 ebsA S Family of unknown function (DUF5322)
HKLECMIN_01006 5.9e-230 pepT 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
HKLECMIN_01007 0.0 lytC 3.4.17.14, 3.5.1.28 M N-acetylmuramoyl-L-alanine amidase
HKLECMIN_01008 3.3e-95 lepB 3.4.21.89 U Belongs to the peptidase S26 family
HKLECMIN_01009 8.3e-224 G COG0457 FOG TPR repeat
HKLECMIN_01010 4.3e-177 yubA S permease
HKLECMIN_01011 1.9e-91 mutX 3.6.1.55 F NTP pyrophosphohydrolases including oxidative damage repair enzymes
HKLECMIN_01012 7.3e-164 ftsX D Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation
HKLECMIN_01013 3.2e-124 ftsE D cell division ATP-binding protein FtsE
HKLECMIN_01014 5.7e-183 prfB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HKLECMIN_01015 1.5e-203 queG 1.17.99.6 C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HKLECMIN_01016 1.8e-153 yjjH S Calcineurin-like phosphoesterase
HKLECMIN_01017 5.3e-133 nfrA 1.5.1.38, 1.5.1.39 C nitroreductase
HKLECMIN_01018 0.0 pacL 3.6.3.8 P cation transport ATPase
HKLECMIN_01019 1e-66 ywiB S Domain of unknown function (DUF1934)
HKLECMIN_01020 7.8e-144 XK27_00115 2.3.1.128 K Acetyltransferase GNAT family
HKLECMIN_01021 7.8e-146 yidA S hydrolases of the HAD superfamily
HKLECMIN_01022 6.7e-226 murM 2.3.2.10, 2.3.2.16 V protein involved in methicillin resistance
HKLECMIN_01023 1.5e-56 S Protein of unknown function (DUF454)
HKLECMIN_01024 3.5e-154 vicX 3.1.26.11 S Metal-dependent hydrolases of the beta-lactamase superfamily I
HKLECMIN_01025 2.7e-219 vicK 2.7.13.3 T Histidine kinase
HKLECMIN_01026 3.8e-128 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HKLECMIN_01027 1e-139 glnQ 3.6.3.21 E abc transporter atp-binding protein
HKLECMIN_01031 2.6e-10
HKLECMIN_01034 2.4e-225 tgt 2.4.2.29 F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
HKLECMIN_01035 3.4e-14 rpmH J Ribosomal protein L34
HKLECMIN_01036 4.7e-97 1.6.5.2 S NADPH-quinone reductase (modulator of drug activity B)
HKLECMIN_01037 3.1e-99 K Transcriptional regulator
HKLECMIN_01038 4e-171 jag S RNA-binding protein
HKLECMIN_01039 8.3e-140 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HKLECMIN_01040 3.5e-52 rnpA 3.1.26.5 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
HKLECMIN_01041 3.3e-269 argH 4.3.2.1 E Argininosuccinate lyase
HKLECMIN_01042 5.8e-230 argG 6.3.4.5 E Belongs to the argininosuccinate synthase family. Type 1 subfamily
HKLECMIN_01043 1.8e-128 fasA KT Response regulator of the LytR AlgR family
HKLECMIN_01044 8e-225 fasC 2.7.13.3 T protein histidine kinase activity
HKLECMIN_01045 1.9e-207 hpk9 2.7.13.3 T protein histidine kinase activity
HKLECMIN_01046 8.8e-151 hpk9 2.7.13.3 T protein histidine kinase activity
HKLECMIN_01047 1.7e-230 2.7.13.3 T signal transduction protein with a C-terminal ATPase domain
HKLECMIN_01048 1.8e-273 gltX 6.1.1.17, 6.1.1.24 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HKLECMIN_01049 0.0 amiA E ABC transporter, substrate-binding protein, family 5
HKLECMIN_01050 1.4e-119 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
HKLECMIN_01051 3.7e-70 rplK J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HKLECMIN_01052 1.2e-50 S Protein of unknown function (DUF3397)
HKLECMIN_01053 1e-87 cah 4.2.1.1 P Reversible hydration of carbon dioxide
HKLECMIN_01054 7e-127 WQ51_05710 S Mitochondrial biogenesis AIM24
HKLECMIN_01055 1.1e-226 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HKLECMIN_01056 6.4e-77 3.5.1.19 Q hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
HKLECMIN_01057 2.7e-79 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
HKLECMIN_01058 6.3e-108 XK27_09620 S FMN reductase (NADPH) activity
HKLECMIN_01059 9.3e-231 XK27_09615 C reductase
HKLECMIN_01060 2.1e-140 fnt P Formate nitrite transporter
HKLECMIN_01061 1.6e-94 XK27_08585 S Psort location CytoplasmicMembrane, score
HKLECMIN_01062 9.7e-186 gpsA 1.1.1.94 I Glycerol-3-phosphate dehydrogenase
HKLECMIN_01063 5.1e-170 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
HKLECMIN_01064 3.1e-116 gluP 3.4.21.105 O membrane protein (homolog of Drosophila rhomboid)
HKLECMIN_01065 1e-93 ygfA 6.3.3.2 H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HKLECMIN_01066 1.1e-219 hipO 3.5.1.47 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
HKLECMIN_01067 7.6e-57 dapD 2.3.1.117, 2.3.1.89 E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
HKLECMIN_01068 7.3e-138 S HAD hydrolase, family IA, variant
HKLECMIN_01069 1.8e-153 rrmA 2.1.1.187 Q methyltransferase
HKLECMIN_01073 1.9e-89 tadA 3.5.4.1, 3.5.4.33 FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
HKLECMIN_01074 6.6e-66 ssb_2 L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
HKLECMIN_01075 1.9e-116 S CAAX protease self-immunity
HKLECMIN_01076 5.1e-113 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HKLECMIN_01078 3.6e-54 ytpP 2.7.1.180, 5.3.4.1 CO Thioredoxin
HKLECMIN_01079 3.5e-08 XK27_10305 S Domain of unknown function (DUF4651)
HKLECMIN_01080 7e-203 pepA 3.4.11.7 G COG1363 Cellulase M and related proteins
HKLECMIN_01081 1.1e-130 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HKLECMIN_01082 1.6e-101 S CAAX amino terminal protease family protein
HKLECMIN_01084 2.6e-107 V CAAX protease self-immunity
HKLECMIN_01085 8.8e-27 lanR K sequence-specific DNA binding
HKLECMIN_01086 2.9e-221 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HKLECMIN_01087 1.1e-175 ytxK 2.1.1.72 L DNA methylase
HKLECMIN_01088 2e-12 comGF U Putative Competence protein ComGF
HKLECMIN_01089 4.5e-71 comGF U Competence protein ComGF
HKLECMIN_01090 3.1e-15 NU Type II secretory pathway pseudopilin
HKLECMIN_01091 3.2e-69 cglD NU Competence protein
HKLECMIN_01092 2.2e-43 comGC U Required for transformation and DNA binding
HKLECMIN_01093 3.4e-141 cglB U protein transport across the cell outer membrane
HKLECMIN_01094 1.1e-175 comGA NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HKLECMIN_01095 1e-68 S cog cog4699
HKLECMIN_01096 0.0 rpoC 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HKLECMIN_01097 0.0 rpoB 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HKLECMIN_01098 0.0 pbp1B 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
HKLECMIN_01099 1.6e-238 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HKLECMIN_01100 1.3e-193 ilvC 1.1.1.86 H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HKLECMIN_01101 5e-76 ilvN 2.2.1.6 E Acetolactate synthase
HKLECMIN_01102 0.0 ilvB 2.2.1.6 EH Acetolactate synthase
HKLECMIN_01103 0.0 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
HKLECMIN_01104 6e-302 yloV S kinase related to dihydroxyacetone kinase
HKLECMIN_01105 1.4e-57 asp S cog cog1302
HKLECMIN_01106 1.2e-225 norN V Mate efflux family protein
HKLECMIN_01107 2.3e-276 thrC 4.2.3.1 E Threonine synthase
HKLECMIN_01110 0.0 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
HKLECMIN_01111 0.0 pepO 3.4.24.71 O Peptidase family M13
HKLECMIN_01112 0.0 treC 3.2.1.93 GH13 G COG0366 Glycosidases
HKLECMIN_01113 0.0 treB 2.7.1.201, 2.7.1.208, 2.7.1.211 G pts system
HKLECMIN_01114 3.3e-124 treR K trehalose operon
HKLECMIN_01115 4.3e-95 ywlG S Belongs to the UPF0340 family
HKLECMIN_01117 1.3e-165 fba 4.1.2.13, 4.1.2.29 G aldolase
HKLECMIN_01119 1.7e-243 6.3.2.2 H gamma-glutamylcysteine synthetase
HKLECMIN_01120 4.4e-62 rplQ J ribosomal protein l17
HKLECMIN_01121 3.6e-171 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HKLECMIN_01122 1.9e-62 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HKLECMIN_01123 4e-57 rpsM J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HKLECMIN_01124 6e-15 rpmJ J Belongs to the bacterial ribosomal protein bL36 family
HKLECMIN_01125 2.7e-32 infA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HKLECMIN_01126 6.2e-114 adk 2.7.4.3 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
HKLECMIN_01127 2.1e-230 secY U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
HKLECMIN_01128 5.7e-58 rplO J binds to the 23S rRNA
HKLECMIN_01129 1.9e-23 rpmD J ribosomal protein l30
HKLECMIN_01130 1.3e-79 rpsE J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HKLECMIN_01131 1.9e-56 rplR J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HKLECMIN_01132 6.6e-93 rplF J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HKLECMIN_01133 1.2e-67 rpsH J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HKLECMIN_01134 1.5e-28 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HKLECMIN_01135 1.6e-94 rplE J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HKLECMIN_01136 1.4e-47 rplX J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HKLECMIN_01137 3.9e-60 rplN J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HKLECMIN_01138 6e-39 rpsQ J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HKLECMIN_01139 3.5e-26 rpmC J Belongs to the universal ribosomal protein uL29 family
HKLECMIN_01140 1.1e-71 rplP J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HKLECMIN_01141 1.6e-117 rpsC J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HKLECMIN_01142 7.3e-53 rplV J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HKLECMIN_01143 8.3e-47 rpsS J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HKLECMIN_01144 6.8e-153 rplB J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HKLECMIN_01145 2.4e-44 rplW J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
HKLECMIN_01146 5.7e-104 rplD J Forms part of the polypeptide exit tunnel
HKLECMIN_01147 2.4e-110 rplC J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HKLECMIN_01148 2.9e-48 rpsJ J Involved in the binding of tRNA to the ribosomes
HKLECMIN_01149 1.1e-186 ruvB 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
HKLECMIN_01150 0.0 XK27_09800 I Acyltransferase
HKLECMIN_01151 2.8e-35 XK27_09805 S MORN repeat protein
HKLECMIN_01152 1.4e-80 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HKLECMIN_01153 4.1e-250 purA 6.3.4.4 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HKLECMIN_01154 4.5e-91 adk 2.7.4.3 F topology modulation protein
HKLECMIN_01155 7.6e-50 yrvD S Lipopolysaccharide assembly protein A domain
HKLECMIN_01156 5e-199 ltrA S Low temperature requirement protein
HKLECMIN_01157 4.7e-80 S Short repeat of unknown function (DUF308)
HKLECMIN_01158 2.1e-88 K sequence-specific DNA binding
HKLECMIN_01159 7.7e-156 L Replication initiation factor
HKLECMIN_01160 1.9e-18 S Domain of unknown function (DUF3173)
HKLECMIN_01161 3.8e-215 int L Belongs to the 'phage' integrase family
HKLECMIN_01163 3.7e-235 rarA L ATPase related to the helicase subunit of the Holliday junction resolvase
HKLECMIN_01164 8.4e-27 rpmB J Belongs to the bacterial ribosomal protein bL28 family
HKLECMIN_01165 6.3e-44 yrzL S Belongs to the UPF0297 family
HKLECMIN_01166 4e-69 yqgF L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HKLECMIN_01167 3.2e-44 yrzB S Belongs to the UPF0473 family
HKLECMIN_01168 1.3e-293 ccs S the current gene model (or a revised gene model) may contain a frame shift
HKLECMIN_01169 0.0 nrdD 1.1.98.6 F Ribonucleoside-triphosphate reductase
HKLECMIN_01170 7.5e-14
HKLECMIN_01171 4.1e-89 XK27_10930 K acetyltransferase
HKLECMIN_01172 2.4e-115 nrdG 1.97.1.4 O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HKLECMIN_01173 4e-122 yaaA S Belongs to the UPF0246 family
HKLECMIN_01174 3.2e-167 XK27_01785 S cog cog1284
HKLECMIN_01175 0.0 aspS 6.1.1.12 J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
HKLECMIN_01177 5e-240 hisS 6.1.1.21 J histidyl-tRNA synthetase
HKLECMIN_01178 4.1e-75 2.7.1.201, 2.7.1.208, 2.7.1.211 G pts system
HKLECMIN_01179 1.7e-129 2.7.1.201, 2.7.1.208, 2.7.1.211 G pts system
HKLECMIN_01180 5.6e-219 metE 2.1.1.14 E Methionine synthase
HKLECMIN_01181 1.5e-25 rpmF J Belongs to the bacterial ribosomal protein bL32 family
HKLECMIN_01182 6.7e-19 rpmG J Belongs to the bacterial ribosomal protein bL33 family
HKLECMIN_01183 1.2e-42 4.2.1.53 S MCRA family
HKLECMIN_01184 9.7e-280 4.2.1.53 S MCRA family
HKLECMIN_01187 6.7e-49 S membrane protein of uknown function UCP014873
HKLECMIN_01189 4.8e-221 sip L Phage integrase, N-terminal SAM-like domain
HKLECMIN_01190 7.3e-61 tnp* 1.1.1.193 L An automated process has identified a potential problem with this gene model
HKLECMIN_01191 1.3e-92 L Transposase
HKLECMIN_01192 9.5e-47 fruR K transcriptional
HKLECMIN_01193 2.2e-35 pfkB 2.7.1.11, 2.7.1.56 H Belongs to the carbohydrate kinase PfkB family. LacC subfamily
HKLECMIN_01194 9.9e-162 T Diguanylate cyclase
HKLECMIN_01195 3.4e-149 2.4.1.83 GT2 M COG0463, glycosyltransferases involved in cell wall biogenesis
HKLECMIN_01196 0.0 bcsA 2.4.1.12 GT2 M COG1215 Glycosyltransferases, probably involved in cell wall biogenesis
HKLECMIN_01197 0.0
HKLECMIN_01198 1.5e-26 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HKLECMIN_01203 2.4e-115 nudL L hydrolase
HKLECMIN_01204 7e-53 K transcriptional regulator, PadR family
HKLECMIN_01205 3.1e-67 XK27_06920 S Protein of unknown function (DUF1700)
HKLECMIN_01206 1.3e-106 S Putative adhesin
HKLECMIN_01207 1.5e-160 XK27_06930 V domain protein
HKLECMIN_01208 9.9e-97 XK27_06935 K transcriptional regulator
HKLECMIN_01209 2e-53 ypaA M Membrane
HKLECMIN_01210 1.9e-10
HKLECMIN_01211 5.8e-109 rpsD J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HKLECMIN_01212 1.8e-47 veg S Biofilm formation stimulator VEG
HKLECMIN_01213 1e-246 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
HKLECMIN_01214 2.2e-73 rplI J binds to the 23S rRNA
HKLECMIN_01215 0.0 yybT T signaling protein consisting of a modified GGDEF domain and a DHH domain
HKLECMIN_01216 0.0 gidA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
HKLECMIN_01217 2.1e-98 yvbG U UPF0056 membrane protein
HKLECMIN_01218 2.1e-218 mnmA 2.8.1.13 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
HKLECMIN_01219 0.0 S Bacterial membrane protein, YfhO
HKLECMIN_01220 7.6e-65 isaA GH23 M Immunodominant staphylococcal antigen A
HKLECMIN_01221 2.7e-71 lytE M LysM domain protein
HKLECMIN_01222 2.8e-132 ecfT P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HKLECMIN_01223 6.8e-153 ecfA2 3.6.3.55 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HKLECMIN_01224 1.1e-150 ecfA1 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HKLECMIN_01225 4.1e-90 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HKLECMIN_01226 5.7e-131 S sequence-specific DNA binding
HKLECMIN_01227 7.5e-236 ymfH S Peptidase M16
HKLECMIN_01228 1.3e-227 ymfF S Peptidase M16
HKLECMIN_01229 3.7e-58 yaaA S S4 domain protein YaaA
HKLECMIN_01230 5e-204 recF L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HKLECMIN_01231 5.6e-275 guaB 1.1.1.205 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
HKLECMIN_01232 1.2e-191 trpS 6.1.1.2 J Tryptophanyl-tRNA synthetase
HKLECMIN_01233 7.1e-153 yvjA S membrane
HKLECMIN_01234 4.3e-305 ybiT S abc transporter atp-binding protein
HKLECMIN_01235 0.0 XK27_10405 S Bacterial membrane protein YfhO
HKLECMIN_01239 2.4e-119 yoaK S Protein of unknown function (DUF1275)
HKLECMIN_01240 2.3e-81 rlmH 2.1.1.177 J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HKLECMIN_01241 1.5e-204 htrA 3.4.21.107 O Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain'
HKLECMIN_01242 2.6e-135 parB K Belongs to the ParB family
HKLECMIN_01243 1e-254 dnaA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HKLECMIN_01244 4.2e-198 dnaN 2.7.7.7 L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
HKLECMIN_01245 3.2e-29 yyzM S Protein conserved in bacteria
HKLECMIN_01246 1.1e-203 ychF J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
HKLECMIN_01247 8.9e-104 pth 3.1.1.29 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
HKLECMIN_01248 0.0 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HKLECMIN_01249 8.2e-39 yabO J Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
HKLECMIN_01250 1.1e-59 divIC D Septum formation initiator
HKLECMIN_01252 1.1e-234 XK27_09285 3.5.2.6 V Beta-lactamase enzyme family
HKLECMIN_01253 2e-233 tilS 2.4.2.8, 6.3.4.19 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
HKLECMIN_01254 2e-97 hpt 2.4.2.8, 6.3.4.19 F Belongs to the purine pyrimidine phosphoribosyltransferase family
HKLECMIN_01255 0.0 ftsH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HKLECMIN_01256 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HKLECMIN_01257 3e-38 ptsH G phosphocarrier protein Hpr
HKLECMIN_01258 5.9e-219 icd 1.1.1.42 C Isocitrate dehydrogenase
HKLECMIN_01259 6.9e-209 citZ 2.3.3.1 C Belongs to the citrate synthase family
HKLECMIN_01260 0.0 acnA 4.2.1.3 C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HKLECMIN_01261 2.2e-34 nrdH O Glutaredoxin
HKLECMIN_01262 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HKLECMIN_01263 2.5e-183 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HKLECMIN_01264 0.0 ileS 6.1.1.5 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HKLECMIN_01265 8.4e-138 divIVA D Cell division initiation protein
HKLECMIN_01266 1.9e-144 ylmH S conserved protein, contains S4-like domain
HKLECMIN_01267 2.9e-30 yggT D integral membrane protein
HKLECMIN_01268 2.2e-86 sepF D cell septum assembly
HKLECMIN_01269 2.3e-122 ylmE S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HKLECMIN_01270 4.7e-233 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HKLECMIN_01271 7.1e-224 ftsA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
HKLECMIN_01272 4.1e-132 divIB D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
HKLECMIN_01273 2.1e-199 murG 2.4.1.227 GT28 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HKLECMIN_01274 1.8e-251 murD 6.3.2.9 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HKLECMIN_01276 0.0 typA T GTP-binding protein TypA
HKLECMIN_01277 7.8e-177 glk 2.7.1.2 G Glucokinase
HKLECMIN_01278 7.1e-27 yqgQ S protein conserved in bacteria
HKLECMIN_01279 1.7e-78 perR P Belongs to the Fur family
HKLECMIN_01280 1.1e-89 dps P Belongs to the Dps family
HKLECMIN_01281 4.6e-104 pilD 3.4.23.43 NOU Type II secretory pathway prepilin signal peptidase PulO and related peptidases
HKLECMIN_01282 2.9e-164 3.5.2.6 V D-alanyl-D-alanine carboxypeptidase
HKLECMIN_01283 1.6e-111 sodA 1.15.1.1 C radicals which are normally produced within the cells and which are toxic to biological systems
HKLECMIN_01284 2.1e-183 holA 2.7.7.7 L DNA polymerase III delta subunit
HKLECMIN_01285 0.0 ppc 4.1.1.31 H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HKLECMIN_01286 2.8e-64 S Domain of unknown function (DUF4430)
HKLECMIN_01287 9.2e-73 S Psort location CytoplasmicMembrane, score
HKLECMIN_01288 1.6e-126 sitB 3.6.3.35 P ABC transporter, ATP-binding protein
HKLECMIN_01289 2.3e-132 mtsC P ABC-type Mn2 Zn2 transport systems, permease components
HKLECMIN_01290 3e-170 sitA P Belongs to the bacterial solute-binding protein 9 family
HKLECMIN_01291 1.9e-118 sirR K iron dependent repressor
HKLECMIN_01292 4e-135 htpX O Belongs to the peptidase M48B family
HKLECMIN_01293 7.7e-92 lemA S LemA family
HKLECMIN_01294 0.0 2.4.1.21 GT5 M Right handed beta helix region
HKLECMIN_01295 3.2e-27 S double-stranded DNA endodeoxyribonuclease activity
HKLECMIN_01296 1.5e-137 S double-stranded DNA endodeoxyribonuclease activity
HKLECMIN_01297 3.1e-303 hsdM 2.1.1.72 V type I restriction-modification system
HKLECMIN_01298 3.4e-127 S Protein conserved in bacteria
HKLECMIN_01299 8.7e-133 hsdS 3.1.21.3 V Type I restriction modification DNA specificity domain
HKLECMIN_01300 0.0
HKLECMIN_01301 9e-14
HKLECMIN_01302 0.0 hsdR 3.1.21.3 L Subunit R is required for both nuclease and ATPase activities, but not for modification
HKLECMIN_01304 3e-131 sdh 1.1.1.276, 1.1.1.313, 1.1.1.381 S Belongs to the short-chain dehydrogenases reductases (SDR) family
HKLECMIN_01305 9.9e-211 MA20_36090 S Protein of unknown function (DUF2974)
HKLECMIN_01306 6.1e-114 1.14.14.5 C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKLECMIN_01307 2.9e-159 5.2.1.8 G hydrolase
HKLECMIN_01308 1.2e-26 P Hemerythrin HHE cation binding domain protein
HKLECMIN_01309 1.6e-139 XK27_00880 3.5.1.28 M Glycosyl hydrolase, family 25
HKLECMIN_01310 3.9e-81 ybaK S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HKLECMIN_01311 5.6e-115 pgm6 5.4.2.11, 5.4.2.12 G Phosphoglycerate mutase
HKLECMIN_01313 5.2e-175 S hydrolase
HKLECMIN_01314 8.4e-23
HKLECMIN_01315 1.8e-139 M LysM domain
HKLECMIN_01316 8.3e-287 lysS 6.1.1.6 J Belongs to the class-II aminoacyl-tRNA synthetase family
HKLECMIN_01317 2.5e-15
HKLECMIN_01318 0.0 L helicase
HKLECMIN_01319 9.5e-65 nudG 3.6.1.55, 3.6.1.65 L Belongs to the Nudix hydrolase family
HKLECMIN_01320 8.1e-11
HKLECMIN_01321 1.6e-233 mntH P H( )-stimulated, divalent metal cation uptake system
HKLECMIN_01322 1.1e-33 XK27_12190 S protein conserved in bacteria
HKLECMIN_01324 2.5e-87 bioY S biotin synthase
HKLECMIN_01325 1.9e-250 yegQ O Peptidase U32
HKLECMIN_01326 1.7e-176 yegQ O Peptidase U32
HKLECMIN_01328 3e-67 ytxH S General stress protein
HKLECMIN_01329 3.7e-08 WQ51_05790 S protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HKLECMIN_01330 1.2e-146 lgt 2.1.1.199 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HKLECMIN_01331 2.2e-168 hprK F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HKLECMIN_01332 2.2e-41 pspC KT PspC domain
HKLECMIN_01333 3.9e-83 ydcK S Belongs to the SprT family
HKLECMIN_01334 0.0 yhgF K Transcriptional accessory protein
HKLECMIN_01336 5.4e-156 XK27_03015 S permease
HKLECMIN_01337 9.9e-149 ycgQ S TIGR03943 family
HKLECMIN_01338 2.7e-167 S CRISPR-associated protein Csn2 subfamily St
HKLECMIN_01339 3.1e-53 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HKLECMIN_01340 3.5e-171 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HKLECMIN_01341 0.0 cas9 L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
HKLECMIN_01342 1.2e-286 sulP P Sulfate permease and related transporters (MFS superfamily)
HKLECMIN_01343 4.4e-101
HKLECMIN_01344 2.7e-117 estA E GDSL-like Lipase/Acylhydrolase
HKLECMIN_01345 3.1e-94 S CAAX protease self-immunity
HKLECMIN_01346 5e-52
HKLECMIN_01348 5.7e-64 yqeB S Pyrimidine dimer DNA glycosylase
HKLECMIN_01349 3.5e-59 S Protein of unknown function (DUF1722)
HKLECMIN_01350 2.1e-17 M Bacterial lipoprotein
HKLECMIN_01351 2e-10
HKLECMIN_01352 2.3e-120 V CAAX protease self-immunity
HKLECMIN_01353 4.6e-46
HKLECMIN_01354 3.6e-76 K TetR family transcriptional regulator
HKLECMIN_01355 4.5e-82 Q Methyltransferase domain
HKLECMIN_01356 2.7e-142 acoC 2.3.1.12, 2.3.1.61 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
HKLECMIN_01357 4.6e-175 acoB C dehydrogenase E1 component
HKLECMIN_01358 3.6e-167 acoA C Acetoin dehydrogenase E1 component subunit alpha
HKLECMIN_01359 1.8e-171 pdhD 1.8.1.4 C Dehydrogenase
HKLECMIN_01360 2.9e-09 S CsbD-like
HKLECMIN_01361 7.2e-31 S Membrane
HKLECMIN_01362 2.1e-172 S Domain of unknown function (DUF389)
HKLECMIN_01363 1.3e-157 yegS 2.7.1.107 I Diacylglycerol kinase
HKLECMIN_01364 3.4e-126 ybbA S Putative esterase
HKLECMIN_01365 4.7e-172 fatB P COG0614 ABC-type Fe3 -hydroxamate transport system, periplasmic component
HKLECMIN_01366 8.3e-134 fecE 3.6.3.34 HP ABC transporter
HKLECMIN_01367 3.6e-159 fecD P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKLECMIN_01368 5.6e-122 V CAAX protease self-immunity
HKLECMIN_01369 1.1e-150 S Domain of unknown function (DUF4300)
HKLECMIN_01370 2.4e-21 S Domain of unknown function (DUF4767)
HKLECMIN_01372 8.6e-108 cutC P Participates in the control of copper homeostasis
HKLECMIN_01373 6.8e-129 S CAAX amino terminal protease family
HKLECMIN_01374 5.2e-96 XK27_08140 K Bacterial regulatory proteins, tetR family
HKLECMIN_01375 3.4e-152 yitS S EDD domain protein, DegV family
HKLECMIN_01376 1.8e-204 yeaN P transporter
HKLECMIN_01377 5.6e-135 S Domain of unknown function (DUF4336)
HKLECMIN_01378 4.1e-136 S hydrolases or acyltransferases (alpha beta hydrolase superfamily)
HKLECMIN_01379 7.8e-130 yceE Q phosphatase activity
HKLECMIN_01380 4.3e-156 ccpB 5.1.1.1 K helix_turn _helix lactose operon repressor
HKLECMIN_01381 2.2e-288 V ABC transporter transmembrane region
HKLECMIN_01382 1e-128 bcrA V abc transporter atp-binding protein
HKLECMIN_01383 4.5e-116 S ABC-type transport system involved in multi-copper enzyme maturation, permease component
HKLECMIN_01384 8.8e-113 K Bacterial regulatory proteins, tetR family
HKLECMIN_01386 1.2e-92
HKLECMIN_01387 3.6e-91 K Acetyltransferase (GNAT) domain
HKLECMIN_01388 1.4e-256 rumA 2.1.1.190 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HKLECMIN_01389 5.9e-97 mip S hydroperoxide reductase activity
HKLECMIN_01390 3.3e-176 I acyl-CoA dehydrogenase
HKLECMIN_01391 6e-94 ydiA P C4-dicarboxylate transporter malic acid transport
HKLECMIN_01392 9.5e-248 msrR K Transcriptional regulator
HKLECMIN_01393 1.4e-153 pheA 4.2.1.51 E Prephenate dehydratase
HKLECMIN_01394 1.3e-79 aroK 1.1.1.25, 2.7.1.71, 4.2.1.10, 4.2.3.4 F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HKLECMIN_01395 7.5e-236 aroA 1.3.1.12, 1.3.1.43, 2.5.1.19 E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
HKLECMIN_01396 3e-165 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
HKLECMIN_01397 9.4e-53 yheA S Belongs to the UPF0342 family
HKLECMIN_01398 4.5e-205 tyrA 1.3.1.12, 1.3.1.43 E prephenate dehydrogenase
HKLECMIN_01399 6.4e-218 aroC 4.2.3.5 E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HKLECMIN_01400 5.9e-202 aroB 2.7.1.71, 4.2.3.4 E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HKLECMIN_01401 3.5e-160 aroE 1.1.1.25 E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HKLECMIN_01402 6.4e-117 aroD 1.1.1.25, 4.2.1.10 E Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
HKLECMIN_01403 3.4e-219 ywbD 2.1.1.191 J Methyltransferase
HKLECMIN_01404 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
HKLECMIN_01405 4.6e-25 WQ51_00785
HKLECMIN_01408 5.2e-64
HKLECMIN_01412 6e-190
HKLECMIN_01413 6.3e-32
HKLECMIN_01414 1.8e-08
HKLECMIN_01415 2.3e-09
HKLECMIN_01416 1.6e-23
HKLECMIN_01417 3.4e-60
HKLECMIN_01418 4.3e-07
HKLECMIN_01419 1.8e-97 S Phage regulatory protein Rha (Phage_pRha)
HKLECMIN_01420 3.8e-25 K sequence-specific DNA binding
HKLECMIN_01421 1.8e-92 K transcriptional
HKLECMIN_01422 1.2e-54 V Abi-like protein
HKLECMIN_01423 1.2e-200 sip L Belongs to the 'phage' integrase family
HKLECMIN_01424 7.4e-247 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
HKLECMIN_01425 3.9e-78 yueI S Protein of unknown function (DUF1694)
HKLECMIN_01426 1.1e-201 glxK 2.7.1.165 G Belongs to the glycerate kinase type-1 family
HKLECMIN_01427 1.5e-200 yyaQ S YjbR
HKLECMIN_01428 1.9e-181 ccpA K Catabolite control protein A
HKLECMIN_01429 9.3e-195 pepQ 3.4.13.9 E Belongs to the peptidase M24B family
HKLECMIN_01430 1.3e-63 yugI 5.3.1.9 J RNA binding protein, contains ribosomal protein S1 domain
HKLECMIN_01431 1.4e-275 ppiB 5.2.1.8 G PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HKLECMIN_01432 6.6e-81 smpB O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
HKLECMIN_01433 0.0 rnr J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
HKLECMIN_01434 2e-33 secG U Preprotein translocase subunit SecG
HKLECMIN_01435 3.2e-220 mdtG EGP Major facilitator Superfamily
HKLECMIN_01436 1.2e-98 coaE 2.7.1.24, 3.2.2.23, 4.2.99.18 GH23 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HKLECMIN_01437 2.4e-150 fpg 3.2.2.23, 4.2.99.18 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
HKLECMIN_01438 1.3e-165 era M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HKLECMIN_01439 2e-65 dgkA 2.7.1.107, 2.7.1.66 M Diacylglycerol kinase
HKLECMIN_01440 4.6e-88 ybeY 2.6.99.2, 3.5.4.5 S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HKLECMIN_01441 5.7e-52 licT K antiterminator
HKLECMIN_01442 7.4e-83 licT K antiterminator
HKLECMIN_01443 1.3e-105 recR L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HKLECMIN_01444 0.0 pbp2b 3.4.16.4 M penicillin-binding protein
HKLECMIN_01445 4.1e-142 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HKLECMIN_01446 2.4e-153 folD 1.5.1.5, 3.5.4.9 F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HKLECMIN_01447 2.3e-147 I Alpha/beta hydrolase family
HKLECMIN_01448 6.6e-08
HKLECMIN_01449 0.0 feoB P transporter of a GTP-driven Fe(2 ) uptake system
HKLECMIN_01450 1.6e-77 feoA P FeoA domain protein
HKLECMIN_01451 2.1e-129 glnQ 3.6.3.21 E abc transporter atp-binding protein
HKLECMIN_01452 5.8e-118 WQ51_01820 P Binding-protein-dependent transport system inner membrane component
HKLECMIN_01453 1e-34 ykuJ S protein conserved in bacteria
HKLECMIN_01454 6.9e-181 argF 2.1.3.3 E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HKLECMIN_01455 0.0 clpE O Belongs to the ClpA ClpB family
HKLECMIN_01456 5.1e-86 mutT 3.5.4.33, 3.6.1.13, 3.6.1.55 L Belongs to the Nudix hydrolase family
HKLECMIN_01457 6.2e-48 XK27_09445 S Domain of unknown function (DUF1827)
HKLECMIN_01458 7.5e-172 S oxidoreductase
HKLECMIN_01459 7.3e-228 murN 2.3.2.16 V FemAB family
HKLECMIN_01460 1.2e-115 M Pfam SNARE associated Golgi protein
HKLECMIN_01461 5.5e-107 S Domain of Unknown Function with PDB structure (DUF3862)
HKLECMIN_01464 1.1e-136 IQ Acetoin reductase
HKLECMIN_01465 2.2e-45 pspE P Rhodanese-like protein
HKLECMIN_01466 9.4e-71 ndk 2.7.4.6 F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
HKLECMIN_01467 2.7e-221 XK27_05470 E Methionine synthase
HKLECMIN_01468 3.6e-257 trmFO 2.1.1.74 J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HKLECMIN_01469 1.2e-239 T PhoQ Sensor
HKLECMIN_01470 2.2e-122 KT Transcriptional regulatory protein, C terminal
HKLECMIN_01471 3.4e-149 S TraX protein
HKLECMIN_01472 0.0 topA 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HKLECMIN_01473 3.3e-155 dprA LU DNA protecting protein DprA
HKLECMIN_01474 2.7e-163 GK ROK family
HKLECMIN_01475 5.3e-136 rnhB 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HKLECMIN_01476 9.4e-158 ylqF S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HKLECMIN_01477 5.3e-127 K DNA-binding helix-turn-helix protein
HKLECMIN_01478 2.3e-90 niaR S small molecule binding protein (contains 3H domain)
HKLECMIN_01479 2.7e-86
HKLECMIN_01480 1e-274 ffh 3.6.5.4 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HKLECMIN_01481 2e-55 ylxM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HKLECMIN_01482 1.3e-125 gntR1 K transcriptional
HKLECMIN_01483 6.7e-303 guaA 2.3.1.128, 6.3.5.2 F Catalyzes the synthesis of GMP from XMP
HKLECMIN_01484 3e-99 rimL J COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
HKLECMIN_01485 7.2e-189 adhP 1.1.1.1 C alcohol dehydrogenase
HKLECMIN_01486 1e-44
HKLECMIN_01487 5.8e-51
HKLECMIN_01488 4e-270 uvrX 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HKLECMIN_01489 1.8e-156 aatB ET ABC transporter substrate-binding protein
HKLECMIN_01490 1.3e-111 glnQ 3.6.3.21 E abc transporter atp-binding protein
HKLECMIN_01491 1.8e-105 artQ P ABC transporter (Permease
HKLECMIN_01492 6.6e-59 phnA P Alkylphosphonate utilization operon protein PhnA
HKLECMIN_01493 0.0 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
HKLECMIN_01494 2.9e-165 cpsY K Transcriptional regulator
HKLECMIN_01495 1e-125 mur1 3.4.17.14, 3.5.1.28 NU muramidase
HKLECMIN_01496 3.8e-166 yeiH S Membrane
HKLECMIN_01498 3.4e-09
HKLECMIN_01499 3.6e-293 adcA P Belongs to the bacterial solute-binding protein 9 family
HKLECMIN_01500 7.9e-146 XK27_10720 D peptidase activity
HKLECMIN_01501 2.1e-276 pepD E Dipeptidase
HKLECMIN_01502 1.3e-160 whiA K May be required for sporulation
HKLECMIN_01503 6.2e-182 ybhK S Required for morphogenesis under gluconeogenic growth conditions
HKLECMIN_01504 4.5e-163 rapZ S Displays ATPase and GTPase activities
HKLECMIN_01505 9.1e-136 yejC S cyclic nucleotide-binding protein
HKLECMIN_01506 3.4e-206 D nuclear chromosome segregation
HKLECMIN_01507 4.2e-94 queF 1.7.1.13 S Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily
HKLECMIN_01508 1.2e-134 queE 1.97.1.4, 4.3.99.3 H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
HKLECMIN_01509 8.8e-83 queD 4.1.2.50, 4.2.3.12 H synthase
HKLECMIN_01510 1.5e-123 queC 6.3.4.20 F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HKLECMIN_01511 2.3e-63 tdcF 3.5.99.10 J endoribonuclease L-PSP
HKLECMIN_01512 5.7e-20
HKLECMIN_01513 8.4e-262 asnS 6.1.1.22 J Catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
HKLECMIN_01514 2.4e-212 aspB 2.6.1.1, 2.6.1.14 E Aminotransferase
HKLECMIN_01515 1.1e-81 ypmB S Protein conserved in bacteria
HKLECMIN_01516 0.0 dinG 2.7.7.7, 3.6.4.12 L helicase involved in DNA repair and perhaps also replication
HKLECMIN_01517 4.7e-114 ycbL 3.1.2.6 S COG0491 Zn-dependent hydrolases, including glyoxylases
HKLECMIN_01518 7.7e-169 yufQ S Belongs to the binding-protein-dependent transport system permease family
HKLECMIN_01519 2.6e-181 yufP S Belongs to the binding-protein-dependent transport system permease family
HKLECMIN_01520 2.1e-277 xylG 3.6.3.17 S ABC transporter, ATP-binding protein
HKLECMIN_01521 3.2e-187 tcsA S membrane
HKLECMIN_01522 3.9e-66 cdd 2.4.2.2, 3.5.4.5 F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
HKLECMIN_01523 7.9e-112 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HKLECMIN_01524 1.6e-230 pdp 2.4.2.2, 2.4.2.4 F Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate
HKLECMIN_01525 1.7e-105 rsmC 2.1.1.172 J Methyltransferase small domain protein
HKLECMIN_01526 3.7e-171 coaA 2.7.1.33 F Pantothenic acid kinase
HKLECMIN_01527 1e-29 rpsT J Binds directly to 16S ribosomal RNA
HKLECMIN_01528 1.7e-241 T PhoQ Sensor
HKLECMIN_01529 5.5e-121 T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HKLECMIN_01530 0.0 fhs 6.3.4.3 F Belongs to the formate--tetrahydrofolate ligase family
HKLECMIN_01531 3.5e-115 coaB 4.1.1.36, 6.3.2.5 H Phosphopantothenate-cysteine ligase
HKLECMIN_01532 8.2e-91 coaBC 4.1.1.36, 6.3.2.5 H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HKLECMIN_01533 2.7e-92 panT S ECF transporter, substrate-specific component
HKLECMIN_01534 0.0 pgm 5.4.2.2, 5.4.2.8 G Phosphoglucomutase
HKLECMIN_01535 5.3e-164 metF 1.5.1.20 E reductase
HKLECMIN_01536 0.0 metE 2.1.1.14 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HKLECMIN_01538 0.0 pabB 2.6.1.85, 4.1.3.27, 4.1.3.38 EH component I
HKLECMIN_01539 0.0 3.6.3.8 P cation transport ATPase
HKLECMIN_01540 2.4e-242 dltD M Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HKLECMIN_01541 2.2e-35 dltC 6.1.1.13 IQ Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HKLECMIN_01542 9.6e-236 dltB M Membrane protein involved in D-alanine export
HKLECMIN_01543 8.4e-298 dltA 6.1.1.13 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HKLECMIN_01544 0.0 XK27_10035 V abc transporter atp-binding protein
HKLECMIN_01545 2.2e-291 yfiB1 V abc transporter atp-binding protein
HKLECMIN_01546 1.9e-99 pvaA M lytic transglycosylase activity
HKLECMIN_01547 4.2e-178 ndpA S 37-kD nucleoid-associated bacterial protein
HKLECMIN_01548 2.7e-230 glyA 2.1.2.1 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HKLECMIN_01549 2.9e-105 ywlC 2.7.7.87, 3.1.3.48 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
HKLECMIN_01550 8.3e-143 prmB 2.1.1.297, 2.1.1.298 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
HKLECMIN_01551 3.6e-191 prfA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HKLECMIN_01552 5.1e-110 tdk 2.7.1.21 F thymidine kinase
HKLECMIN_01553 1.8e-184 add 3.5.4.4 F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HKLECMIN_01554 4.9e-153 gst O Glutathione S-transferase
HKLECMIN_01555 1e-176 nrnA 3.1.13.3, 3.1.3.7 S domain protein
HKLECMIN_01556 3.5e-174 apbE 2.7.1.180 H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
HKLECMIN_01557 4.4e-45 rpmE2 J 50S ribosomal protein L31
HKLECMIN_01558 9.7e-203 mntH P Mn2 and Fe2 transporters of the NRAMP family
HKLECMIN_01559 2.7e-16 mntH P Mn2 and Fe2 transporters of the NRAMP family
HKLECMIN_01560 6.4e-163 ypuA S secreted protein
HKLECMIN_01561 2e-70 yaeR E COG0346 Lactoylglutathione lyase and related lyases
HKLECMIN_01562 9.3e-133 srtA 3.4.22.70 M Sortase (surface protein transpeptidase)
HKLECMIN_01563 0.0 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HKLECMIN_01564 1.6e-180 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
HKLECMIN_01565 7.8e-255 noxE P NADH oxidase
HKLECMIN_01566 2.1e-293 yfmM S abc transporter atp-binding protein
HKLECMIN_01567 2.3e-82 XK27_01265 S ECF-type riboflavin transporter, S component
HKLECMIN_01568 5.9e-136 pdxK 2.7.1.35 H Belongs to the pyridoxine kinase family
HKLECMIN_01569 9.4e-81 S ECF-type riboflavin transporter, S component
HKLECMIN_01571 5.7e-236 XK27_08130 K Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
HKLECMIN_01572 7e-56 nrdD_1 1.1.98.6, 1.17.4.1 F Ribonucleoside-triphosphate reductase
HKLECMIN_01574 0.0 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HKLECMIN_01575 1.5e-45 paiA 2.3.1.57 K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HKLECMIN_01576 1.2e-36 paiA 2.3.1.57 K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HKLECMIN_01577 1.1e-197 pheS 6.1.1.20 J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HKLECMIN_01578 1e-22 WQ51_00220 K Helix-turn-helix domain
HKLECMIN_01579 5.5e-79 S Protein of unknown function (DUF3278)
HKLECMIN_01580 0.0 smc D Required for chromosome condensation and partitioning
HKLECMIN_01581 2.5e-124 rnc 3.1.26.3 J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
HKLECMIN_01582 1.1e-172 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HKLECMIN_01583 1.1e-198 asd 1.2.1.11 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HKLECMIN_01584 3.6e-117 alkD L Dna alkylation repair
HKLECMIN_01585 1.1e-284 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HKLECMIN_01586 5.2e-87 pat 2.3.1.183 M acetyltransferase
HKLECMIN_01587 3.4e-269 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HKLECMIN_01588 1.8e-279 opuD M Belongs to the BCCT transporter (TC 2.A.15) family
HKLECMIN_01589 3.4e-36 P (belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HKLECMIN_01590 0.0 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
HKLECMIN_01591 1.3e-128 yjjG 3.1.3.102, 3.1.3.104, 3.1.3.5, 3.8.1.2 E hydrolase
HKLECMIN_01592 1.4e-119 sdaAB 4.3.1.17 E L-serine dehydratase
HKLECMIN_01593 4.4e-147 sdaAA 4.3.1.17 E L-serine dehydratase
HKLECMIN_01594 0.0 fruA 3.2.1.1, 3.2.1.26, 3.2.1.65, 3.2.1.80 GH13,GH32 G Belongs to the glycosyl hydrolase 32 family
HKLECMIN_01595 1.6e-132 L Integrase
HKLECMIN_01596 2e-202 S Protein of unknown function DUF262
HKLECMIN_01597 2.1e-151 S Protein of unknown function DUF262
HKLECMIN_01598 3.8e-78 mutT 3.6.1.55 F COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
HKLECMIN_01599 3.1e-79 3.4.21.89 S RDD family
HKLECMIN_01600 1.2e-153 K sequence-specific DNA binding
HKLECMIN_01601 6e-149 V ABC transporter, ATP-binding protein
HKLECMIN_01602 1.8e-93 S ABC-2 family transporter protein
HKLECMIN_01603 1.6e-134 K sequence-specific DNA binding
HKLECMIN_01604 2.7e-51 ywrO S general stress protein
HKLECMIN_01605 0.0 prtA 3.2.1.23 O Belongs to the peptidase S8 family
HKLECMIN_01606 5.7e-77 K Acetyltransferase (GNAT) domain
HKLECMIN_01607 3.3e-141 S ABC-2 family transporter protein
HKLECMIN_01608 6.9e-142 S ABC-2 family transporter protein
HKLECMIN_01609 3.2e-186 S abc transporter atp-binding protein
HKLECMIN_01610 2.4e-49 L COG1943 Transposase and inactivated derivatives
HKLECMIN_01611 3.9e-31
HKLECMIN_01613 0.0 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HKLECMIN_01614 0.0 mutS2 L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
HKLECMIN_01615 6.1e-94 cvpA S toxin biosynthetic process
HKLECMIN_01616 2.7e-14 zapA D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HKLECMIN_01617 2e-155 rnhC 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HKLECMIN_01618 1.4e-113 lepB 3.4.21.89 U Belongs to the peptidase S26 family
HKLECMIN_01619 0.0 recD2 3.1.11.5 L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
HKLECMIN_01620 4.8e-46 azlD S branched-chain amino acid
HKLECMIN_01621 3e-114 azlC E AzlC protein
HKLECMIN_01622 8.2e-185 tsaD 2.3.1.234 O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HKLECMIN_01623 2.6e-71 rimI 2.3.1.128 K This enzyme acetylates the N-terminal alanine of ribosomal protein S18
HKLECMIN_01624 3.9e-114 yeaZ 2.3.1.234 O COG1214, inactive homolog of metal-dependent proteases
HKLECMIN_01625 4.3e-33 ykzG S Belongs to the UPF0356 family
HKLECMIN_01626 0.0 rnjA S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HKLECMIN_01627 2.5e-115 pscB M CHAP domain protein
HKLECMIN_01628 6.8e-264 glnA 6.3.1.2 E glutamine synthetase
HKLECMIN_01629 8.5e-63 glnR K Transcriptional regulator
HKLECMIN_01630 2.5e-86 S Fusaric acid resistance protein-like
HKLECMIN_01631 1.7e-221 pgk 2.7.2.3, 5.3.1.1 F Belongs to the phosphoglycerate kinase family
HKLECMIN_01632 2.4e-114
HKLECMIN_01633 7.1e-181 gap 1.2.1.12 C Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
HKLECMIN_01634 0.0 fusA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HKLECMIN_01635 3.9e-81 rpsG J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
HKLECMIN_01636 2.3e-69 rpsL J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HKLECMIN_01637 4e-142 purR 2.4.2.7 F operon repressor
HKLECMIN_01638 3.1e-178 cbf S 3'-5' exoribonuclease yhaM
HKLECMIN_01639 4.2e-170 rmuC S RmuC domain protein
HKLECMIN_01640 5.8e-112 thiN 2.7.6.2 H thiamine pyrophosphokinase
HKLECMIN_01641 7.8e-120 rpe 5.1.3.1 G Belongs to the ribulose-phosphate 3-epimerase family
HKLECMIN_01642 2.4e-161 rsgA 3.1.3.100 G One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
HKLECMIN_01644 1.9e-153 ksgA 2.1.1.182 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
HKLECMIN_01645 2.5e-98 rnmV 3.1.26.8 J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HKLECMIN_01646 4e-142 tatD L Hydrolase, tatd
HKLECMIN_01647 1.7e-70 yccU S CoA-binding protein
HKLECMIN_01648 2.4e-50 trxA O Belongs to the thioredoxin family
HKLECMIN_01649 1.5e-141 S Macro domain protein
HKLECMIN_01650 1.2e-57 L thioesterase
HKLECMIN_01651 4.3e-50 bta 1.8.1.8 CO cell redox homeostasis
HKLECMIN_01652 1.5e-37 M domain, Protein
HKLECMIN_01653 8.1e-86 L Transposase
HKLECMIN_01654 0.0 zmpB M signal peptide protein, YSIRK family
HKLECMIN_01655 0.0 GM domain, Protein
HKLECMIN_01656 3e-218 sbcD L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
HKLECMIN_01657 0.0 sbcC L ATPase involved in DNA repair
HKLECMIN_01658 0.0 M family 8
HKLECMIN_01659 6.1e-211 secY2 U Part of the accessory SecA2 SecY2 system specifically required for export of
HKLECMIN_01660 1.8e-287 asp1 S Accessory Sec system protein Asp1
HKLECMIN_01661 3.5e-288 asp2 3.4.11.5 S Accessory Sec system protein Asp2
HKLECMIN_01662 3.8e-78 asp3 S Accessory Sec system protein Asp3
HKLECMIN_01663 0.0 secA2 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
HKLECMIN_01664 7.7e-280 gtf1 2.4.1.52 GT4 M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
HKLECMIN_01665 1.8e-243 gtf2 M A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1
HKLECMIN_01666 2.6e-17 S Accessory secretory protein Sec Asp4
HKLECMIN_01667 3.6e-16 S Accessory secretory protein Sec, Asp5
HKLECMIN_01668 3.6e-185 nss M transferase activity, transferring glycosyl groups
HKLECMIN_01669 6.5e-277 fliF 2.1.1.72 N bacterial-type flagellum-dependent cell motility
HKLECMIN_01677 6.8e-19
HKLECMIN_01678 0.0 2.4.1.5 GH13 M KxYKxGKxW signal domain protein
HKLECMIN_01679 0.0 3.5.1.28 M domain protein
HKLECMIN_01680 2.3e-136 S N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity
HKLECMIN_01681 1.3e-232 L DNA binding domain of tn916 integrase
HKLECMIN_01682 1.8e-30 xis S Excisionase from transposon Tn916
HKLECMIN_01683 9.3e-36 S Helix-turn-helix domain
HKLECMIN_01684 1.1e-71 phyR K Sigma-70, region 4
HKLECMIN_01685 6e-58 K Helix-turn-helix domain
HKLECMIN_01686 0.0 tetP J elongation factor G
HKLECMIN_01687 4.8e-168 S Conjugative transposon protein TcpC
HKLECMIN_01688 2.2e-190 yddH M NlpC p60 family protein
HKLECMIN_01689 0.0 S the current gene model (or a revised gene model) may contain a frame shift
HKLECMIN_01690 0.0 S AAA-like domain
HKLECMIN_01691 3.8e-90 S TcpE family
HKLECMIN_01692 7.5e-91 S Antirestriction protein (ArdA)
HKLECMIN_01693 1.9e-30 S Psort location CytoplasmicMembrane, score
HKLECMIN_01694 1.6e-232 K Replication initiation factor
HKLECMIN_01695 7.2e-214 L Belongs to the 'phage' integrase family
HKLECMIN_01696 4.5e-10 S Domain of unknown function (DUF3173)
HKLECMIN_01697 1.8e-87 L Replication initiation factor
HKLECMIN_01699 2.5e-12 K Transcriptional
HKLECMIN_01700 1.4e-38
HKLECMIN_01701 3.7e-265 D Domain of unknown function DUF87
HKLECMIN_01702 1e-63 S Bacterial protein of unknown function (DUF961)
HKLECMIN_01703 2.7e-44 S Bacterial protein of unknown function (DUF961)
HKLECMIN_01704 4.3e-87 V abc transporter atp-binding protein
HKLECMIN_01705 2.2e-15
HKLECMIN_01707 1.5e-73 K Transcriptional regulatory protein, C terminal
HKLECMIN_01708 5.8e-64 2.7.13.3 T Histidine kinase
HKLECMIN_01709 5.9e-92 maa 2.3.1.79 GK Maltose O-acetyltransferase
HKLECMIN_01710 2.2e-64 rmaI K Transcriptional regulator, MarR family
HKLECMIN_01711 3.4e-234 EGP Major facilitator Superfamily
HKLECMIN_01712 3.2e-133 XK27_00785 S CAAX protease self-immunity
HKLECMIN_01714 0.0 M Putative cell wall binding repeat
HKLECMIN_01715 0.0 S dextransucrase activity
HKLECMIN_01716 1.5e-173 S dextransucrase activity
HKLECMIN_01717 0.0 M Putative cell wall binding repeat
HKLECMIN_01718 0.0 M Putative cell wall binding repeat
HKLECMIN_01719 0.0 M Putative cell wall binding repeat
HKLECMIN_01720 1.8e-156 pdxS 4.3.3.6 H Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HKLECMIN_01721 2.3e-102 pdxT 4.3.3.6 H Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HKLECMIN_01722 0.0 S dextransucrase activity
HKLECMIN_01723 0.0 M Putative cell wall binding repeat
HKLECMIN_01724 0.0 S dextransucrase activity
HKLECMIN_01725 0.0 S dextransucrase activity
HKLECMIN_01726 0.0 S dextransucrase activity
HKLECMIN_01727 0.0 2.4.1.5 GH13 M KxYKxGKxW signal domain protein
HKLECMIN_01728 2e-235 S dextransucrase activity
HKLECMIN_01730 0.0 2.4.1.5 GH13 M KxYKxGKxW signal domain protein
HKLECMIN_01732 9.4e-114 yhfC S Putative membrane peptidase family (DUF2324)
HKLECMIN_01733 1.1e-43 czrA K helix_turn_helix, Arsenical Resistance Operon Repressor
HKLECMIN_01736 1.1e-189 mccF V LD-carboxypeptidase
HKLECMIN_01737 1.5e-07 S Enterocin A Immunity
HKLECMIN_01738 0.0 pepO 3.4.24.71 O Peptidase family M13
HKLECMIN_01739 5.4e-34 S Immunity protein 41
HKLECMIN_01740 0.0 M Putative cell wall binding repeat
HKLECMIN_01741 7.7e-225 thrE K Psort location CytoplasmicMembrane, score
HKLECMIN_01742 8e-177 dhaK 2.7.1.121, 2.7.1.28, 2.7.1.29, 4.6.1.15 G Dihydroxyacetone kinase
HKLECMIN_01743 6.9e-96 dhaL 2.7.1.121 S Dihydroxyacetone kinase
HKLECMIN_01744 5.7e-59 dhaM 2.7.1.121 S dihydroxyacetone kinase, phosphotransfer subunit
HKLECMIN_01745 1e-179 XK27_10475 S oxidoreductase
HKLECMIN_01746 3.8e-196 gldA 1.1.1.6 C glycerol dehydrogenase
HKLECMIN_01748 5e-284 XK27_07020 S Belongs to the UPF0371 family
HKLECMIN_01749 1.7e-211 vex1 V Efflux ABC transporter, permease protein
HKLECMIN_01750 1.9e-107 vex2 V abc transporter atp-binding protein
HKLECMIN_01751 8.6e-238 vex3 V Efflux ABC transporter, permease protein
HKLECMIN_01752 4.4e-115 K Response regulator receiver domain protein
HKLECMIN_01753 2.1e-225 vncS 2.7.13.3 T Histidine kinase
HKLECMIN_01754 2.7e-307 dexB 3.2.1.10, 3.2.1.70 GH13 G COG0366 Glycosidases
HKLECMIN_01755 1.2e-151 galR K Transcriptional regulator
HKLECMIN_01756 4.8e-221 galK 2.7.1.6 G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HKLECMIN_01757 1.9e-283 galT 2.7.7.12 G UDPglucose--hexose-1-phosphate uridylyltransferase
HKLECMIN_01758 1.1e-194 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
HKLECMIN_01759 1.1e-200 galM 5.1.3.3 G Catalyzes the interconversion of alpha and beta anomers of maltose
HKLECMIN_01760 0.0 lacS G transporter
HKLECMIN_01761 0.0 lacL 3.2.1.23 G -beta-galactosidase
HKLECMIN_01762 1.4e-212 S Tetratricopeptide repeat
HKLECMIN_01763 7.1e-158 yvgN C reductase
HKLECMIN_01764 1.9e-30 XK27_10490
HKLECMIN_01765 5.3e-40 DJ nuclease activity
HKLECMIN_01766 1.9e-97 yoaK S Protein of unknown function (DUF1275)
HKLECMIN_01767 3.5e-109 drgA C nitroreductase
HKLECMIN_01768 1.1e-223 pts13C G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HKLECMIN_01769 5.9e-152 E Alpha/beta hydrolase of unknown function (DUF915)
HKLECMIN_01770 4.3e-77 ywnA K Transcriptional regulator
HKLECMIN_01771 2e-152 1.13.11.2 S glyoxalase
HKLECMIN_01772 6.3e-108 XK27_02070 S nitroreductase
HKLECMIN_01773 9.7e-36
HKLECMIN_01774 1.6e-26 XK27_07105 K transcriptional
HKLECMIN_01775 3.7e-07 S Protein of unknown function (DUF3169)
HKLECMIN_01776 2e-166 ydhF S Aldo keto reductase
HKLECMIN_01777 6.2e-97 K WHG domain
HKLECMIN_01778 1.5e-121 V abc transporter atp-binding protein
HKLECMIN_01779 9.8e-203 P FtsX-like permease family
HKLECMIN_01780 2e-42 S Sugar efflux transporter for intercellular exchange
HKLECMIN_01781 2.5e-83 btuE 1.11.1.9 O Belongs to the glutathione peroxidase family
HKLECMIN_01782 0.0 S dextransucrase activity
HKLECMIN_01783 2.1e-215 yfnA E amino acid
HKLECMIN_01784 1.5e-50 XK27_01300 S ASCH
HKLECMIN_01785 2.6e-105 S Carbohydrate-binding domain-containing protein Cthe_2159
HKLECMIN_01786 3.9e-14 csbD K CsbD-like
HKLECMIN_01787 5e-108 S Protein of unknown function (DUF421)
HKLECMIN_01788 2.7e-55 S Protein of unknown function (DUF3290)
HKLECMIN_01789 8.7e-181 manA 5.3.1.8 G mannose-6-phosphate isomerase
HKLECMIN_01790 1.8e-232 brnQ E Component of the transport system for branched-chain amino acids
HKLECMIN_01791 7.4e-131 T ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HKLECMIN_01792 0.0 S Domain of unknown function DUF87
HKLECMIN_01793 1.8e-30 T DNase/tRNase domain of colicin-like bacteriocin
HKLECMIN_01794 7.4e-14
HKLECMIN_01795 4.8e-187 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HKLECMIN_01797 3e-243 norM V Multidrug efflux pump
HKLECMIN_01798 4.3e-147 K sequence-specific DNA binding
HKLECMIN_01799 2.6e-278 V (ABC) transporter
HKLECMIN_01800 2.5e-223 pbuX F xanthine permease
HKLECMIN_01801 6.7e-99 xpt 2.4.2.22, 2.4.2.7 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
HKLECMIN_01802 2.7e-123 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HKLECMIN_01803 4.9e-163 T Histidine kinase
HKLECMIN_01804 1.6e-132 macB2 V ABC transporter, ATP-binding protein
HKLECMIN_01805 0.0 V ABC transporter (permease)
HKLECMIN_01806 6.1e-93 XK27_05000 S metal cluster binding
HKLECMIN_01807 3.4e-30 liaI KT membrane
HKLECMIN_01808 1.1e-15 liaI KT membrane
HKLECMIN_01809 5.3e-156 XK27_09825 V abc transporter atp-binding protein
HKLECMIN_01810 1.5e-132 yvfS V Transporter
HKLECMIN_01811 2.1e-81 cdd 2.4.2.4, 3.5.4.5 F cytidine deaminase activity
HKLECMIN_01812 5.1e-165 yocS S Transporter
HKLECMIN_01815 1e-159 XK27_09825 V abc transporter atp-binding protein
HKLECMIN_01816 9e-133 yvfS V ABC-2 type transporter
HKLECMIN_01817 5.9e-189 desK 2.7.13.3 T Histidine kinase
HKLECMIN_01818 4.4e-101 desR K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HKLECMIN_01819 2.4e-49 L COG1943 Transposase and inactivated derivatives
HKLECMIN_01821 1.1e-222 mutY L A G-specific adenine glycosylase
HKLECMIN_01822 5.5e-42 XK27_05745
HKLECMIN_01823 1.1e-46 rpsF J Binds together with S18 to 16S ribosomal RNA
HKLECMIN_01824 2.5e-81 ssb L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
HKLECMIN_01825 1.7e-35 rpsR J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HKLECMIN_01827 7.2e-121 XK27_01040 S Protein of unknown function (DUF1129)
HKLECMIN_01828 5e-168 corA P COG0598 Mg2 and Co2 transporters
HKLECMIN_01829 0.0 uvrA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HKLECMIN_01835 1.6e-146 V 'abc transporter, ATP-binding protein
HKLECMIN_01837 5.4e-187 pepP 3.4.11.9, 3.4.13.9 E Belongs to the peptidase M24B family
HKLECMIN_01838 3.3e-85 comEB 3.5.4.12 F ComE operon protein 2
HKLECMIN_01839 7.1e-98 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HKLECMIN_01840 1.7e-61 yqhY S protein conserved in bacteria
HKLECMIN_01841 8.1e-73 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HKLECMIN_01842 2e-180 scrR K Transcriptional regulator
HKLECMIN_01843 1.7e-289 scrB 3.2.1.26, 3.2.1.80 GH32 G invertase
HKLECMIN_01844 0.0 scrA 2.7.1.201, 2.7.1.208, 2.7.1.211 G pts system
HKLECMIN_01845 2e-171 scrK 2.7.1.2, 2.7.1.4 GK Fructokinase
HKLECMIN_01846 9.6e-188 manA 5.3.1.8 G mannose-6-phosphate isomerase
HKLECMIN_01848 0.0 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
HKLECMIN_01849 1.9e-197 aroF 2.5.1.54 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HKLECMIN_01850 5.5e-197 aroF 2.5.1.54 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HKLECMIN_01851 1.7e-60 acpS 2.7.6.3, 2.7.8.7, 5.1.1.1 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
HKLECMIN_01852 2.7e-181 alr 5.1.1.1, 5.1.1.5 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HKLECMIN_01853 0.0 recG 3.6.4.12 L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HKLECMIN_01855 2.3e-159 V ABC transporter
HKLECMIN_01856 1.9e-122
HKLECMIN_01860 2.9e-31 yozG K Transcriptional regulator
HKLECMIN_01862 1.1e-178 ansA 3.5.1.1 EJ COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D
HKLECMIN_01863 1.2e-258 XK27_03190 5.2.1.8 S hydrolases of the HAD superfamily
HKLECMIN_01864 2.2e-109 yebC M Membrane
HKLECMIN_01865 0.0 KT response to antibiotic
HKLECMIN_01866 2e-74 XK27_02470 K LytTr DNA-binding domain protein
HKLECMIN_01867 1.8e-119 liaI S membrane
HKLECMIN_01868 1.9e-59 tcyB_2 P ABC transporter (permease)
HKLECMIN_01869 3.2e-153 endA F DNA RNA non-specific endonuclease
HKLECMIN_01870 2.7e-25 epuA S DNA-directed RNA polymerase subunit beta
HKLECMIN_01871 6.5e-232 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HKLECMIN_01872 3.7e-11 S Protein of unknown function (DUF1146)
HKLECMIN_01873 1.1e-194 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
HKLECMIN_01874 3.2e-134 G Domain of unknown function (DUF4832)
HKLECMIN_01875 2e-83 S membrane
HKLECMIN_01876 1e-96 P VTC domain
HKLECMIN_01877 1e-222 cotH M CotH kinase protein
HKLECMIN_01878 3.8e-183 pelG M Putative exopolysaccharide Exporter (EPS-E)
HKLECMIN_01879 3e-270 pelF GT4 M Domain of unknown function (DUF3492)
HKLECMIN_01880 0.0 S Uncharacterised protein conserved in bacteria (DUF2194)
HKLECMIN_01881 1.3e-144
HKLECMIN_01882 3.5e-276 5.1.3.2 GM Psort location CytoplasmicMembrane, score
HKLECMIN_01883 1e-210 metK 2.5.1.6 H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HKLECMIN_01884 3.3e-172 birA 6.3.4.15 HK Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
HKLECMIN_01885 2.7e-302 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HKLECMIN_01886 5.7e-86 ytsP 1.8.4.14 T GAF domain-containing protein
HKLECMIN_01887 2.2e-160 miaA 2.5.1.75 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HKLECMIN_01888 3.2e-20 WQ51_02665 S Protein of unknown function (DUF3042)
HKLECMIN_01891 1.1e-56 rplS J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
HKLECMIN_01892 5.2e-210 XK27_05110 P Chloride transporter ClC family
HKLECMIN_01893 1.8e-38 pheA 1.3.1.12, 2.3.1.79, 4.2.1.51, 5.4.99.5 E Chorismate mutase
HKLECMIN_01894 2.1e-280 clcA P Chloride transporter, ClC family
HKLECMIN_01895 1e-75 fld C Flavodoxin
HKLECMIN_01896 2.2e-18 XK27_08880
HKLECMIN_01897 1.6e-126 XK27_08875 O Zinc-dependent metalloprotease
HKLECMIN_01898 9.5e-149 estA CE1 S Esterase
HKLECMIN_01899 1e-309 rnjB S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HKLECMIN_01900 3.1e-136 XK27_08845 S abc transporter atp-binding protein
HKLECMIN_01901 2.6e-147 XK27_08840 S Belongs to the binding-protein-dependent transport system permease family
HKLECMIN_01902 4e-176 XK27_08835 S ABC transporter substrate binding protein
HKLECMIN_01903 1.7e-18 S Domain of unknown function (DUF4649)
HKLECMIN_01904 0.0 htaA 3.4.21.72 Q the current gene model (or a revised gene model) may contain a frame shift
HKLECMIN_01905 1e-276 pyk 2.7.1.40, 2.7.7.4 G Belongs to the pyruvate kinase family
HKLECMIN_01906 5.1e-187 pfkA 2.7.1.11 F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
HKLECMIN_01907 0.0 dnaE 2.7.7.7 L DNA polymerase
HKLECMIN_01908 1.1e-112 leuD 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HKLECMIN_01909 1.4e-275 leuC 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HKLECMIN_01910 3.5e-37 ysdA L Membrane
HKLECMIN_01911 1.1e-189 leuB 1.1.1.85 CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
HKLECMIN_01912 4.9e-290 leuA 2.3.3.13 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HKLECMIN_01913 2.1e-131 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HKLECMIN_01914 8.9e-178 pyrD 1.3.1.14, 1.3.98.1 F Catalyzes the conversion of dihydroorotate to orotate
HKLECMIN_01916 6.3e-39 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
HKLECMIN_01917 8.3e-94 ypmS S Protein conserved in bacteria
HKLECMIN_01918 6.9e-156 ypmR E COG2755 Lysophospholipase L1 and related esterases
HKLECMIN_01919 4.9e-143 DegV S DegV family
HKLECMIN_01920 1.3e-301 recN L May be involved in recombinational repair of damaged DNA
HKLECMIN_01921 8.3e-73 argR K Regulates arginine biosynthesis genes
HKLECMIN_01922 1.9e-147 rrmJ 2.1.1.226, 2.1.1.227 J Ribosomal RNA large subunit methyltransferase J
HKLECMIN_01923 9.3e-153 ispA 2.5.1.1, 2.5.1.10, 2.5.1.29, 2.5.1.90 H Belongs to the FPP GGPP synthase family
HKLECMIN_01924 4.6e-29 xseB 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HKLECMIN_01925 2.5e-234 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HKLECMIN_01927 1.9e-118 nth 4.2.99.18 L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HKLECMIN_01928 1.3e-125 dnaD
HKLECMIN_01929 1.6e-182 metA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HKLECMIN_01930 3.8e-93 apt 2.4.2.22, 2.4.2.7 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HKLECMIN_01931 0.0 recJ L Single-strand DNA-specific exonuclease, C terminal domain
HKLECMIN_01932 8e-67 GnaT 2.5.1.16 K acetyltransferase
HKLECMIN_01933 6.7e-139 XK27_05435 1.1.1.100 S Belongs to the short-chain dehydrogenases reductases (SDR) family
HKLECMIN_01934 2.7e-174 rnz 3.1.26.11 S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
HKLECMIN_01935 7.6e-112 galT 2.7.7.12 G UDPglucose--hexose-1-phosphate uridylyltransferase
HKLECMIN_01936 7.1e-245 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HKLECMIN_01937 1.4e-227 rodA D Belongs to the SEDS family
HKLECMIN_01938 0.0 2.4.1.5 GH13 M KxYKxGKxW signal domain protein
HKLECMIN_01939 0.0 2.4.1.5 GH13 M KxYKxGKxW signal domain protein
HKLECMIN_01940 0.0 2.4.1.5 GH13 M KxYKxGKxW signal domain protein
HKLECMIN_01941 5.7e-178 XK27_08075 M glycosyl transferase family 2
HKLECMIN_01942 1.2e-97 S Carbohydrate-binding domain-containing protein Cthe_2159
HKLECMIN_01943 3.2e-144 P molecular chaperone
HKLECMIN_01944 3.8e-93 XK27_05505 S Psort location CytoplasmicMembrane, score
HKLECMIN_01946 9.1e-50 hisE 3.5.4.19, 3.6.1.31, 5.3.1.16 E phosphoribosyl-ATP diphosphatase activity
HKLECMIN_01947 2e-58 hisI 3.5.4.19, 3.5.4.25, 3.6.1.31, 5.3.1.16 E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HKLECMIN_01948 9.6e-138 hisF 3.5.4.19, 3.6.1.31 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
HKLECMIN_01949 5.3e-130 hisA 5.3.1.16 E 1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HKLECMIN_01950 1.5e-109 hisH E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HKLECMIN_01951 5.7e-106 hisB 1.1.1.23, 2.6.1.9, 3.1.3.15, 4.2.1.19 E imidazoleglycerol-phosphate dehydratase
HKLECMIN_01952 3.2e-234 hisD 1.1.1.23, 1.1.1.308 E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HKLECMIN_01953 5.5e-118 hisG 2.4.2.17 E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
HKLECMIN_01954 1.9e-178 hisZ 2.4.2.17, 6.1.1.21 E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HKLECMIN_01955 7.2e-192 hisC 2.6.1.9 E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HKLECMIN_01956 2.7e-59 XK27_08085
HKLECMIN_01957 2.8e-147 XK27_08080 3.1.1.53 G Exopolysaccharide biosynthesis protein
HKLECMIN_01958 2.3e-136 hisK 3.1.3.15 E Histidinol phosphatase and related hydrolases of the PHP family
HKLECMIN_01959 5.1e-116 ylfI S tigr01906
HKLECMIN_01960 1.5e-138 nagD 2.7.1.25, 3.1.3.41 G Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
HKLECMIN_01961 1.2e-140 fat 3.1.2.21 I Acyl-ACP thioesterase
HKLECMIN_01962 5.5e-214 hemN H Involved in the biosynthesis of porphyrin-containing compound
HKLECMIN_01963 2.2e-30 KT response to antibiotic
HKLECMIN_01965 1.3e-204 rfbB 4.2.1.46 M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
HKLECMIN_01966 2.7e-111 rmlC 1.1.1.133, 5.1.3.13 M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
HKLECMIN_01967 2.4e-161 rfbA 2.7.7.24 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HKLECMIN_01968 6.9e-256 S phospholipase Carboxylesterase
HKLECMIN_01969 1.4e-195 yurR 1.4.5.1 E oxidoreductase
HKLECMIN_01970 7e-142 zupT P Mediates zinc uptake. May also transport other divalent cations
HKLECMIN_01971 6.6e-142 yqfO 3.5.4.16 S Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HKLECMIN_01972 4e-119 trmK 2.1.1.217 S SAM-dependent methyltransferase
HKLECMIN_01973 3.5e-65 gtrA S GtrA-like protein
HKLECMIN_01974 5.7e-250 glmM 5.4.2.10 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HKLECMIN_01975 2.7e-161 ybbR S Protein conserved in bacteria
HKLECMIN_01976 2.7e-149 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HKLECMIN_01977 8.4e-254 murD 3.4.21.10, 6.3.2.13, 6.3.2.9 M Mur ligase, middle domain protein
HKLECMIN_01978 1.4e-147 cobQ S glutamine amidotransferase
HKLECMIN_01979 0.0 mprF 2.3.2.3 J Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HKLECMIN_01980 3.3e-132 pip 1.11.1.10 S Alpha beta hydrolase

eggNOG-mapper v2 (Database: eggNOG v5.0, Jul. 2018 release)