ORF_ID e_value Gene_name EC_number CAZy COGs Description
HICBILPI_00001 1.6e-26 wapA M COG3209 Rhs family protein
HICBILPI_00002 8.7e-63 wapA M COG3209 Rhs family protein
HICBILPI_00003 1.1e-12 wapA M COG3209 Rhs family protein
HICBILPI_00004 5.8e-49 wapA M COG3209 Rhs family protein
HICBILPI_00005 1.1e-22 wapA M COG3209 Rhs family protein
HICBILPI_00006 3.5e-80 wapA M COG3209 Rhs family protein
HICBILPI_00007 4.3e-29
HICBILPI_00008 2.1e-36 yxiG
HICBILPI_00012 3.2e-110
HICBILPI_00013 2.8e-20
HICBILPI_00015 2e-261 dbpA 3.6.4.13 JKL DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes
HICBILPI_00016 7.6e-127 yxiO S COG2270 Permeases of the major facilitator superfamily
HICBILPI_00017 1.6e-74 yxiO S COG2270 Permeases of the major facilitator superfamily
HICBILPI_00018 2.7e-20 licT K transcriptional antiterminator
HICBILPI_00019 2.3e-70 licT K transcriptional antiterminator
HICBILPI_00021 2e-140 exoK GH16 M licheninase activity
HICBILPI_00022 1.4e-221 citH C Citrate transporter
HICBILPI_00023 0.0 katE 1.11.1.6, 3.5.1.124 P serves to protect cells from the toxic effects of hydrogen peroxide
HICBILPI_00024 1.5e-49 yxiS
HICBILPI_00025 3.6e-72 T Domain of unknown function (DUF4163)
HICBILPI_00026 3e-210 nupG F Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HICBILPI_00027 5.9e-155 rlmA 2.1.1.187 Q Methyltransferase domain
HICBILPI_00028 4.8e-218 yxjG 2.1.1.14 E Methionine synthase
HICBILPI_00029 2e-85 yxjI S LURP-one-related
HICBILPI_00032 1.8e-234 pepT 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
HICBILPI_00033 8.2e-193 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
HICBILPI_00034 3.8e-87 yxkC S Domain of unknown function (DUF4352)
HICBILPI_00035 3.4e-143 yxkD S Uncharacterised 5xTM membrane BCR, YitT family COG1284
HICBILPI_00036 2e-163 lrp QT PucR C-terminal helix-turn-helix domain
HICBILPI_00037 2.6e-205 msmK P Belongs to the ABC transporter superfamily
HICBILPI_00038 1.6e-154 yxkH G Polysaccharide deacetylase
HICBILPI_00039 1e-214 cimH C COG3493 Na citrate symporter
HICBILPI_00040 4.5e-266 cydA 1.10.3.14 C oxidase, subunit
HICBILPI_00041 1.1e-186 cydB 1.10.3.14 C Cytochrome d ubiquinol oxidase, subunit II
HICBILPI_00042 0.0 cydD V ATP-binding
HICBILPI_00043 1.3e-291 cydD V ATP-binding protein
HICBILPI_00044 8e-154 nnrD 4.2.1.136, 5.1.99.6 G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HICBILPI_00045 5.5e-192 yxlA F Belongs to the purine-cytosine permease (2.A.39) family
HICBILPI_00046 6.8e-49 yxlA F Belongs to the purine-cytosine permease (2.A.39) family
HICBILPI_00047 1.4e-194 yxeI 3.5.1.24 M Linear amide C-N hydrolases, choloylglycine hydrolase family
HICBILPI_00048 0.0 katX 1.11.1.6 P serves to protect cells from the toxic effects of hydrogen peroxide
HICBILPI_00049 2.1e-210 gmuG 3.2.1.78 GH26 G Belongs to the glycosyl hydrolase 26 family
HICBILPI_00050 6.9e-186 manA 5.3.1.8 G mannose-6-phosphate isomerase
HICBILPI_00051 2.4e-164 gmuE 2.7.1.2, 2.7.1.4 GK COG1940 Transcriptional regulator sugar kinase
HICBILPI_00052 2.1e-284 ydhP 3.2.1.21, 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
HICBILPI_00053 2.3e-227 celB 2.7.1.207 G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HICBILPI_00054 2.3e-48 ydhN3 2.7.1.196, 2.7.1.205 G phosphotransferase system
HICBILPI_00055 1.3e-48 ydhM 2.7.1.196, 2.7.1.205 G phosphotransferase system
HICBILPI_00056 2.5e-226 arsB P Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HICBILPI_00057 1.7e-57 arsR K transcriptional
HICBILPI_00058 1.5e-166 cbrA3 P Periplasmic binding protein
HICBILPI_00059 7.9e-180 fhuG1 P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HICBILPI_00060 4.7e-172 fhuB3 P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HICBILPI_00061 1.3e-110 mpg 3.2.2.21 L Belongs to the DNA glycosylase MPG family
HICBILPI_00062 0.0 licR 2.7.1.202 GKT Mga helix-turn-helix domain
HICBILPI_00063 1.2e-49 licB 2.7.1.196, 2.7.1.205 G transporter subunit IIB
HICBILPI_00064 7.4e-250 licC 2.7.1.207 G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HICBILPI_00065 5.1e-51 licA 2.7.1.196, 2.7.1.205 G phosphotransferase system
HICBILPI_00066 3e-251 licH 3.2.1.86 GT4 G COG1486 Alpha-galactosidases 6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases
HICBILPI_00067 7.1e-203 ilvE 2.6.1.42 E Branched-chain amino acid aminotransferase
HICBILPI_00068 3.1e-228 dltD M COG3966 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HICBILPI_00069 1.5e-36 dltC 6.1.1.13 IQ Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HICBILPI_00070 1.1e-228 dltB M membrane protein involved in D-alanine export
HICBILPI_00071 3.3e-291 dltA 6.1.1.13 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HICBILPI_00072 6.1e-12 S D-Ala-teichoic acid biosynthesis protein
HICBILPI_00073 1.3e-168 menA 2.5.1.74 H Belongs to the MenA family. Type 1 subfamily
HICBILPI_00074 7.8e-117 ywaC 2.7.6.5 S protein conserved in bacteria
HICBILPI_00075 1.9e-196 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HICBILPI_00076 7.1e-49 ywaE K Transcriptional regulator
HICBILPI_00077 4.1e-161 gspA M General stress
HICBILPI_00078 6.4e-262 epr 3.4.21.62 O Belongs to the peptidase S8 family
HICBILPI_00079 7.1e-245 celB 2.7.1.207 G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HICBILPI_00080 7.6e-67 ywbC 4.4.1.5 E glyoxalase
HICBILPI_00081 3e-223 ywbD 2.1.1.191 J Methyltransferase
HICBILPI_00082 2.6e-135 mta K transcriptional
HICBILPI_00083 1.8e-27 ywbE S Uncharacterized conserved protein (DUF2196)
HICBILPI_00084 1.3e-109 ywbG M effector of murein hydrolase
HICBILPI_00085 4.2e-57 ywbH S Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein. When a cell is stressed by the addition of antibiotics or by other factors in the environment, CidA possibly oligomerizes within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are also hypothesized to regulate the subsequent cell lysis by either allowing the murein hydrolases access to the cell wall substrate and or regulating their activity by a
HICBILPI_00086 8.2e-152 ywbI K Transcriptional regulator
HICBILPI_00087 1.3e-135 thiM 2.7.1.50 H Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HICBILPI_00088 7.2e-113 thiE 2.5.1.3, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
HICBILPI_00089 1.1e-242 ywbN P Dyp-type peroxidase family protein
HICBILPI_00090 3e-110 ywbO Q dithiol-disulfide isomerase involved in polyketide biosynthesis
HICBILPI_00091 6e-114 S Streptomycin biosynthesis protein StrF
HICBILPI_00092 1.1e-127 H Methionine biosynthesis protein MetW
HICBILPI_00094 3.1e-110 ywcC K Bacterial regulatory proteins, tetR family
HICBILPI_00095 5.1e-61 gtcA S GtrA-like protein
HICBILPI_00096 3.6e-293 galT 2.7.7.12 G UDP-glucose--hexose-1-phosphate uridylyltransferase
HICBILPI_00097 8.4e-27 ywzA S membrane
HICBILPI_00098 4.1e-178 cyoA 1.10.3.10, 1.10.3.12 C Catalyzes quinol oxidation with the concomitant reduction of oxygen to water. Subunit II transfers the electrons from a quinol to the binuclear center of the catalytic subunit I
HICBILPI_00099 0.0 qoxB 1.10.3.12, 1.9.3.1 C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HICBILPI_00100 8.1e-111 qoxC 1.10.3.12, 1.9.3.1 C quinol oxidase, subunit
HICBILPI_00101 2.4e-62 qoxD 1.10.3.12, 1.9.3.1 C quinol oxidase, subunit
HICBILPI_00102 1e-38 ywcE S Required for proper spore morphogenesis. Important for spore germination
HICBILPI_00103 1.7e-76 ysnE K acetyltransferase
HICBILPI_00104 2.8e-208 rodA D Belongs to the SEDS family
HICBILPI_00105 2e-135 nfrA 1.5.1.38, 1.5.1.39 C Oxidoreductase
HICBILPI_00106 6.8e-184 ywcH C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HICBILPI_00107 0.0 vpr O Belongs to the peptidase S8 family
HICBILPI_00109 2.8e-151 sacT K transcriptional antiterminator
HICBILPI_00110 3.1e-93 scrA 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
HICBILPI_00111 9.4e-147 scrA 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
HICBILPI_00112 1.9e-283 scrB 3.2.1.26, 3.2.1.65 GH32 G invertase
HICBILPI_00113 7.4e-20 ywdA
HICBILPI_00114 6e-146 thiD 2.5.1.3, 2.7.1.35, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Phosphomethylpyrimidine kinase
HICBILPI_00115 6.3e-57 pex K Transcriptional regulator PadR-like family
HICBILPI_00116 1.5e-88 ywdD
HICBILPI_00118 4.7e-150 ywdF GT2,GT4 S Glycosyltransferase like family 2
HICBILPI_00119 1.4e-132 ung 3.2.2.27 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HICBILPI_00120 4.7e-41 ywdI S Family of unknown function (DUF5327)
HICBILPI_00121 5.4e-229 ywdJ F Xanthine uracil
HICBILPI_00122 4.2e-46 ywdK S small membrane protein
HICBILPI_00123 4e-61 gerQ S Essential for the localization of CwlJ in the spore coat and for spore germination triggered by calcium and dipicolinic acid (DPA). Its assembly into the spore coat is dependent on the coat morphogenetic proteins CotE and SpoIVA
HICBILPI_00124 1.7e-142 spsA M Spore Coat
HICBILPI_00125 9.1e-275 spsB M Capsule polysaccharide biosynthesis protein
HICBILPI_00126 4e-220 spsC E Belongs to the DegT DnrJ EryC1 family
HICBILPI_00127 8.9e-156 spsD 2.3.1.210 K Spore Coat
HICBILPI_00128 1.2e-213 spsE 2.5.1.56 M acid synthase
HICBILPI_00129 5.9e-132 spsF M Spore Coat
HICBILPI_00130 1.7e-179 spsG M Spore Coat
HICBILPI_00131 1.2e-137 spsI 2.7.7.24 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HICBILPI_00132 7.9e-182 rfbB 4.2.1.46 M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
HICBILPI_00133 4e-161 spsK 1.1.1.133 M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
HICBILPI_00134 3e-86 spsL 5.1.3.13 M Spore Coat
HICBILPI_00135 1.9e-59
HICBILPI_00136 7.3e-247 rocG 1.4.1.2, 1.4.1.3 E Belongs to the Glu Leu Phe Val dehydrogenases family
HICBILPI_00137 1e-295 putA 1.2.1.88, 1.5.5.2 C Belongs to the aldehyde dehydrogenase family. RocA subfamily
HICBILPI_00138 0.0 rocB E arginine degradation protein
HICBILPI_00139 1.2e-258 lysP E amino acid
HICBILPI_00140 2.5e-204 tcaB EGP Major facilitator Superfamily
HICBILPI_00141 3.5e-222 ywfA EGP Major facilitator Superfamily
HICBILPI_00142 3.9e-113 pheA 1.1.1.3, 1.3.1.12, 4.1.1.100, 4.2.1.51, 5.4.99.5 E Part of the bacABCDEF operon responsible for the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase. BacA is an unusual prephenate decarboxylase that avoids the typical aromatization of the cyclohexadienol ring of prephenate. BacA catalyzes the protonation of prephenate (1-carboxy-4-hydroxy-alpha-oxo-2,5-cyclohexadiene-1- propanoic acid) at C6 position, followed by a decarboxylation to produce the endocyclic-delta(4),delta(8)-7R-dihydro- hydroxyphenylpyruvate (en-H2HPP). En-H2HPP is able to undergo a slow nonenzymatic isomerization to produce the exocyclic- delta(3),delta(5)-dihydro-hydroxyphenylpyruvate (ex-H2HPP). BacA isomerizes only the pro-R double bond in prephenate
HICBILPI_00143 7.6e-137 bacB 5.3.3.19, 5.4.99.5 S Part of the bacABCDEF operon responsible for the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase. BacB catalyzes the allylic isomerization of the
HICBILPI_00144 8.7e-139 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HICBILPI_00145 2.4e-267 purD 6.3.2.49, 6.3.4.13 F Part of the bacABCDEFG operon responsible for the biosynthesis of bacilysin, an irreversible inactivator of the glutaminase domain of glucosamine synthetase. Catalyzes the formation of alpha-dipeptides from various L-amino acids in the presence of ATP. In vivo catalyzes the ligation of L-alanine and L-anticapsin (epoxycyclohexanonyl-Ala) to produce the final bacilysin antibiotic (L-Ala-L-4S-cyclohexenonyl-Ala dipeptide)
HICBILPI_00146 1e-207 bacE EGP Major facilitator Superfamily
HICBILPI_00147 8.6e-234 ywfG 2.6.1.83 E Aminotransferase class I and II
HICBILPI_00148 1.1e-139 IQ Enoyl-(Acyl carrier protein) reductase
HICBILPI_00149 1.1e-146 ywfI C May function as heme-dependent peroxidase
HICBILPI_00150 5.1e-176 pta 2.3.1.19, 2.3.1.8, 3.6.3.21 C In Salmonella this enzyme is required for ethanolamine catabolism
HICBILPI_00151 6.2e-158 MA20_14895 S Conserved hypothetical protein 698
HICBILPI_00152 6e-163 cysL K Transcriptional regulator
HICBILPI_00153 1.2e-155 lipL 2.3.1.200, 2.3.1.204 H Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes
HICBILPI_00155 4.5e-174
HICBILPI_00158 7.2e-167 yhcI S ABC transporter (permease)
HICBILPI_00159 2.1e-163 V ABC transporter, ATP-binding protein
HICBILPI_00160 3.4e-92 S membrane
HICBILPI_00161 9.7e-52 padR K PadR family transcriptional regulator
HICBILPI_00162 6.6e-110 rsfA_1
HICBILPI_00163 6.9e-36 ywzC S Belongs to the UPF0741 family
HICBILPI_00164 3e-256 ywfO S COG1078 HD superfamily phosphohydrolases
HICBILPI_00165 4.6e-88 ywgA 2.1.1.72, 3.1.21.3
HICBILPI_00166 1.2e-144 yhdG_1 E C-terminus of AA_permease
HICBILPI_00167 5.8e-75 yhdG_1 E C-terminus of AA_permease
HICBILPI_00168 4.9e-67 ywhA K Transcriptional regulator
HICBILPI_00169 1.3e-24 dmpI 5.3.2.6 G 4-oxalocrotonate tautomerase
HICBILPI_00170 1.2e-117 ywhC S Peptidase family M50
HICBILPI_00171 1.9e-92 ywhD S YwhD family
HICBILPI_00172 1.8e-80
HICBILPI_00173 0.0 pbpG 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
HICBILPI_00174 4.1e-158 speE 2.5.1.16 E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HICBILPI_00175 7.8e-168 speB 3.5.3.11 E Belongs to the arginase family
HICBILPI_00178 1.3e-74 CP Membrane
HICBILPI_00180 1.6e-31
HICBILPI_00181 9.7e-29 ydcG K sequence-specific DNA binding
HICBILPI_00183 3e-71 S aspartate phosphatase
HICBILPI_00184 2.9e-43 ywiB S protein conserved in bacteria
HICBILPI_00185 0.0 argS 6.1.1.19 J Arginyl-tRNA synthetase
HICBILPI_00186 5.4e-212 narK P COG2223 Nitrate nitrite transporter
HICBILPI_00187 8.5e-128 fnr K helix_turn_helix, cAMP Regulatory protein
HICBILPI_00188 2.8e-139 ywiC S YwiC-like protein
HICBILPI_00189 1.7e-84 arfM T cyclic nucleotide binding
HICBILPI_00190 1.6e-55 narG 1.7.5.1 C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HICBILPI_00191 7e-245 narG 1.7.5.1 C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HICBILPI_00192 0.0 narG 1.7.5.1 C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HICBILPI_00193 3.7e-295 narH 1.7.5.1 C Nitrate reductase, beta
HICBILPI_00194 1.7e-91 narJ 1.7.5.1 C nitrate reductase
HICBILPI_00195 2.1e-120 narI 1.7.5.1 C nitrate reductase, gamma
HICBILPI_00196 3.4e-104 S Uncharacterised 5xTM membrane BCR, YitT family COG1284
HICBILPI_00197 1.6e-296 ywiE I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HICBILPI_00198 7.7e-18 ywjA V ABC transporter
HICBILPI_00199 1.6e-288 ywjA V ABC transporter
HICBILPI_00200 4.2e-43 ywjC
HICBILPI_00201 2.2e-179 uvsE L Component in a DNA repair pathway. Removal of UV-light damaged nucleotides. Recognizes pyrimidine dimers and cleave a phosphodiester bond immediately 5' to the lesion
HICBILPI_00202 2.3e-218 clsB I Belongs to the phospholipase D family. Cardiolipin synthase subfamily
HICBILPI_00203 0.0 fadF C COG0247 Fe-S oxidoreductase
HICBILPI_00204 2.4e-47 rpoE K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
HICBILPI_00205 0.0 pyrG 6.3.4.2 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
HICBILPI_00206 4.2e-92 ywjG S Domain of unknown function (DUF2529)
HICBILPI_00207 8.5e-63 spo0F T COG0784 FOG CheY-like receiver
HICBILPI_00208 5.5e-158 fbaA 4.1.2.13, 4.1.2.29 G Aldolase
HICBILPI_00209 1.9e-110 tal 2.2.1.2 G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HICBILPI_00210 3.3e-239 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HICBILPI_00211 5.6e-175 glpX 3.1.3.11, 3.1.3.37 G fructose-1,6-bisphosphatase
HICBILPI_00212 4.3e-239 rho K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HICBILPI_00213 1.1e-32 rpmE J Binds the 23S rRNA
HICBILPI_00214 2.5e-101 tdk 2.7.1.21 F thymidine kinase
HICBILPI_00215 0.0 sfcA 1.1.1.38 C malic enzyme
HICBILPI_00216 6.8e-157 ywkB S Membrane transport protein
HICBILPI_00217 2.2e-94 racA K Required for the formation of axial filaments and for anchoring the origin regions at the cell poles in sporulating cells, thus ensuring proper chromosome segregation in the prespore. Binds in a dispersed manner throughout the chromosome but preferentially to sites clustered in the origin portion of the chromosome, causing condensation of the chromosome and its remodeling into an elongated, anchored structure
HICBILPI_00218 2e-67 yaeR E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HICBILPI_00219 1.9e-192 prfA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HICBILPI_00220 4.8e-154 prmC 2.1.1.297 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
HICBILPI_00222 1.4e-60 ywlA S Uncharacterised protein family (UPF0715)
HICBILPI_00223 8.9e-119 spoIIR S stage II sporulation protein R
HICBILPI_00224 1.1e-74 ywlB 1.20.4.1, 2.3.1.1 E Belongs to the acetyltransferase family. ArgA subfamily
HICBILPI_00225 1.4e-50 ywlC 2.7.7.87, 3.1.3.48 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
HICBILPI_00226 1.7e-114 ywlC 2.7.7.87, 3.1.3.48 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
HICBILPI_00227 1.3e-83 mntP P Probably functions as a manganese efflux pump
HICBILPI_00228 1.3e-76 ywlE 3.1.3.48, 3.9.1.2, 5.3.1.6 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HICBILPI_00229 1.1e-80 rpiB 5.3.1.6 G Ribose 5-phosphate isomerase
HICBILPI_00230 1e-96 ywlG S Belongs to the UPF0340 family
HICBILPI_00231 5.6e-236 glyA 2.1.2.1 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HICBILPI_00232 1e-113 upp 2.4.2.9 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HICBILPI_00233 2.1e-61 atpI S ATP synthase
HICBILPI_00234 5.4e-130 atpB C it plays a direct role in the translocation of protons across the membrane
HICBILPI_00235 1.6e-26 atpE C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HICBILPI_00236 1.3e-42 atpF C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HICBILPI_00237 4.5e-89 atpH C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HICBILPI_00238 8.2e-282 atpA 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HICBILPI_00239 5.9e-152 atpG C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HICBILPI_00240 2.4e-267 atpD 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HICBILPI_00241 1.8e-63 atpC C Produces ATP from ADP in the presence of a proton gradient across the membrane
HICBILPI_00242 8.7e-89 ywmA
HICBILPI_00243 4.8e-32 ywzB S membrane
HICBILPI_00244 2.2e-134 ywmB S TATA-box binding
HICBILPI_00245 1.1e-239 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HICBILPI_00246 4e-179 spoIID D Stage II sporulation protein D
HICBILPI_00247 5.1e-114 ywmC S protein containing a von Willebrand factor type A (vWA) domain
HICBILPI_00248 6.6e-122 ywmD S protein containing a von Willebrand factor type A (vWA) domain
HICBILPI_00250 2.4e-144 fdhD C Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HICBILPI_00251 1.2e-191 moaA 4.1.99.22, 4.6.1.17 H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HICBILPI_00252 3.7e-93 S response regulator aspartate phosphatase
HICBILPI_00253 2.3e-81 ywmF S Peptidase M50
HICBILPI_00254 3.2e-10 csbD K CsbD-like
HICBILPI_00255 1.2e-49 ureA 3.5.1.5 E Belongs to the urease gamma subunit family
HICBILPI_00256 1.9e-62 ureB 3.5.1.5 E Belongs to the urease beta subunit family
HICBILPI_00257 0.0 ureC 3.5.1.5 E Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family
HICBILPI_00258 6.1e-67 ywnA K Transcriptional regulator
HICBILPI_00260 2e-120 xlnB 3.2.1.8 G Glycosyl hydrolases family 11
HICBILPI_00261 1.2e-51 ywnC S Family of unknown function (DUF5362)
HICBILPI_00262 4.2e-275 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HICBILPI_00263 4.2e-69 ywnF S Family of unknown function (DUF5392)
HICBILPI_00264 1.2e-10 ywnC S Family of unknown function (DUF5362)
HICBILPI_00265 9.2e-89 ywnH 2.3.1.183 M COG1247 Sortase and related acyltransferases
HICBILPI_00266 1.4e-121 spoIIQ M COG0739 Membrane proteins related to metalloendopeptidases
HICBILPI_00267 8.1e-70 ywnJ S VanZ like family
HICBILPI_00268 5.4e-101 bcrC 3.6.1.27 I COG0671 Membrane-associated phospholipid phosphatase
HICBILPI_00269 5.1e-207 ftsW D Belongs to the SEDS family
HICBILPI_00270 2e-58 nrgB K Belongs to the P(II) protein family
HICBILPI_00271 4.6e-216 amt P Ammonium transporter
HICBILPI_00272 4.8e-102 phzA Q Isochorismatase family
HICBILPI_00273 1.6e-244 ywoD EGP Major facilitator superfamily
HICBILPI_00274 4.6e-274 ybbW FH COG1953 Cytosine uracil thiamine allantoin permeases
HICBILPI_00275 1.4e-212 ywoG EGP Major facilitator Superfamily
HICBILPI_00276 2.5e-71 ywoH K transcriptional
HICBILPI_00277 8.2e-32 spoIIID K Stage III sporulation protein D
HICBILPI_00278 2.7e-180 mbl D Rod shape-determining protein
HICBILPI_00279 5.5e-128 flhO N flagellar basal body
HICBILPI_00280 4.5e-141 flhP N flagellar basal body
HICBILPI_00281 5.2e-198 S aspartate phosphatase
HICBILPI_00282 4.9e-75 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
HICBILPI_00283 1.4e-47 mscL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
HICBILPI_00284 2.5e-68 ywpF S YwpF-like protein
HICBILPI_00285 4e-62 ywpG
HICBILPI_00286 3.7e-57 ssbB L Single-stranded DNA-binding protein
HICBILPI_00287 7.5e-138 glcR K DeoR C terminal sensor domain
HICBILPI_00288 1.7e-154 ywpJ 3.1.3.104 S hydrolases of the HAD superfamily
HICBILPI_00289 0.0 ywqA L COG0553 Superfamily II DNA RNA helicases, SNF2 family
HICBILPI_00290 1.6e-307 ywqB S SWIM zinc finger
HICBILPI_00291 1.3e-14
HICBILPI_00292 1.8e-109 ywqC M biosynthesis protein
HICBILPI_00293 1.1e-119 ywqD 2.7.10.1 D COG0489 ATPases involved in chromosome partitioning
HICBILPI_00294 3e-139 ywqE 3.1.3.48 GM COG4464 Capsular polysaccharide biosynthesis protein
HICBILPI_00295 2.9e-246 ugd 1.1.1.22 M Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HICBILPI_00296 3.4e-146 ywqG S Domain of unknown function (DUF1963)
HICBILPI_00298 1.4e-21 S Domain of unknown function (DUF5082)
HICBILPI_00299 7.3e-37 ywqI S Family of unknown function (DUF5344)
HICBILPI_00300 7.5e-306 ywqJ S Pre-toxin TG
HICBILPI_00302 9.7e-14
HICBILPI_00303 8.4e-131 nfi 3.1.21.7 L DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA
HICBILPI_00304 9e-156 K Transcriptional regulator
HICBILPI_00305 1.5e-92 ywqN S NAD(P)H-dependent
HICBILPI_00307 1.6e-86 ywrA P COG2059 Chromate transport protein ChrA
HICBILPI_00308 9.5e-101 ywrB P Chromate transporter
HICBILPI_00309 2.5e-83 ywrC K Transcriptional regulator
HICBILPI_00310 6.3e-288 ggt 2.3.2.2, 3.4.19.13 E gamma-glutamyltransferase
HICBILPI_00312 1.3e-111 ywrF S COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HICBILPI_00313 2e-09
HICBILPI_00314 5e-212 cotH M Spore Coat
HICBILPI_00315 2.8e-128 cotB
HICBILPI_00316 7.5e-126 ywrJ
HICBILPI_00317 2.7e-236 ywrK P Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HICBILPI_00319 2.6e-166 alsR K LysR substrate binding domain
HICBILPI_00320 2e-308 alsS 2.2.1.6 EH Belongs to the TPP enzyme family
HICBILPI_00321 7.9e-148 budA 4.1.1.5 H Alpha-acetolactate decarboxylase
HICBILPI_00322 5.3e-95 ywrO 1.6.5.2 S NADPH-quinone reductase (modulator of drug activity B)
HICBILPI_00323 9.8e-89 batE T Sh3 type 3 domain protein
HICBILPI_00324 3.7e-160 rbsB G COG1879 ABC-type sugar transport system, periplasmic component
HICBILPI_00325 1.4e-154 rbsC G Belongs to the binding-protein-dependent transport system permease family
HICBILPI_00326 7.1e-278 rbsA 3.6.3.17 G Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system
HICBILPI_00327 4e-63 rbsD 5.4.99.62 G Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose
HICBILPI_00328 2.4e-156 rbsK 2.7.1.15, 2.7.1.4 H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HICBILPI_00329 3.2e-178 rbsR K transcriptional
HICBILPI_00330 1.5e-203 gerKC S Spore germination B3/ GerAC like, C-terminal
HICBILPI_00331 8.2e-191 gerKB E Spore germination protein
HICBILPI_00332 7.7e-184 gerKA EG Spore germination protein
HICBILPI_00333 1e-223 murD 6.3.2.9 M COG0769 UDP-N-acetylmuramyl tripeptide synthase
HICBILPI_00334 2.3e-70 pgsC S biosynthesis protein
HICBILPI_00335 2.8e-218 capA M enzyme of poly-gamma-glutamate biosynthesis (capsule formation)
HICBILPI_00336 1.3e-20 ywtC
HICBILPI_00337 7.3e-236 pgdS CBM50 M COG0791 Cell wall-associated hydrolases (invasion-associated proteins)
HICBILPI_00338 3.2e-34 yttA 2.7.13.3 S Pfam Transposase IS66
HICBILPI_00339 4.7e-157 ywtE 3.1.3.104 S hydrolases of the HAD superfamily
HICBILPI_00340 7.2e-178 ywtF K Transcriptional regulator
HICBILPI_00341 4.9e-249 ywtG EGP Major facilitator Superfamily
HICBILPI_00342 1.5e-266 GT2,GT4 J Glycosyl transferase family 2
HICBILPI_00343 7.1e-52 gerAC S Spore germination protein
HICBILPI_00344 1.9e-86 gerAC S Spore germination protein
HICBILPI_00345 4.8e-33 gerAC S Spore germination protein
HICBILPI_00346 7.8e-197 gerBB E Spore germination protein
HICBILPI_00347 9.7e-264 gerBA EG Spore germination protein
HICBILPI_00348 7.7e-185 pmi 5.3.1.8 G mannose-6-phosphate isomerase
HICBILPI_00349 2.3e-239 atl 3.2.1.96, 3.5.1.28 GH73 G Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
HICBILPI_00350 5.5e-217 tagB 2.7.8.14, 2.7.8.44, 2.7.8.47 M glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HICBILPI_00351 3.8e-142 tagA 2.4.1.187 GT26 M Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid
HICBILPI_00352 3.4e-70 tagD 2.7.7.15, 2.7.7.39 IM Cytidylyltransferase
HICBILPI_00353 7.8e-280 M Glycosyltransferase like family 2
HICBILPI_00354 0.0 tagF 2.7.8.12 M glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HICBILPI_00355 1.7e-151 tagG GM Transport permease protein
HICBILPI_00356 1.1e-281 tagH 3.6.3.38, 3.6.3.40 GM Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system
HICBILPI_00357 2.8e-165 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
HICBILPI_00358 2e-208 mnaA 5.1.3.14 M Belongs to the UDP-N-acetylglucosamine 2-epimerase family
HICBILPI_00359 1.7e-149 lytR K May catalyze the final step in cell wall teichoic acid biosynthesis, the transfer of the anionic cell wall polymers (APs) from their lipid-linked precursor to the cell wall peptidoglycan (PG)
HICBILPI_00360 2.3e-48
HICBILPI_00361 5.8e-96 lytB 3.5.1.28 D Stage II sporulation protein
HICBILPI_00362 1.3e-265 lytB 3.5.1.28 D Stage II sporulation protein
HICBILPI_00363 3e-268 lytC 3.5.1.28 M n-acetylmuramoyl-L-alanine amidase
HICBILPI_00364 1.4e-90 tuaA M COG2148 Sugar transferases involved in lipopolysaccharide synthesis
HICBILPI_00365 3.7e-15 tuaA M COG2148 Sugar transferases involved in lipopolysaccharide synthesis
HICBILPI_00366 1.8e-257 wzxC S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
HICBILPI_00367 2.6e-222 tuaC 2.4.1.21, 3.2.1.1 GH13,GT4,GT5 GM Teichuronic acid
HICBILPI_00368 4.9e-246 tuaD 1.1.1.22 M Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HICBILPI_00369 1.5e-253 tuaE M Teichuronic acid biosynthesis protein
HICBILPI_00370 3.3e-113 tuaF M protein involved in exopolysaccharide biosynthesis
HICBILPI_00371 8.9e-144 tuaG GT2 M Glycosyltransferase like family 2
HICBILPI_00372 1.1e-233 tuaH M Teichuronic acid biosynthesis glycosyltransferase tuaH
HICBILPI_00373 1.1e-182 tagO 2.7.8.33, 2.7.8.35 M COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase UDP-N-acetylglucosamine-1-phosphate transferase
HICBILPI_00374 3.9e-165 yvhJ K Transcriptional regulator
HICBILPI_00375 3.8e-119 yvyE 3.4.13.9 S Domain of unknown function (DUF1949)
HICBILPI_00376 2.4e-180 degS 2.7.13.3 T Member of the two-component regulatory system DegS DegU, which plays an important role in the transition growth phase
HICBILPI_00377 2e-126 degU KT COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HICBILPI_00378 1.9e-158 degV S protein conserved in bacteria
HICBILPI_00379 1.3e-254 comFA L COG4098 Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HICBILPI_00380 1.1e-41 comFB S Late competence development protein ComFB
HICBILPI_00381 6.6e-108 comFC S Phosphoribosyl transferase domain
HICBILPI_00382 1.2e-73 yvyF S flagellar protein
HICBILPI_00383 4.7e-39 flgM KNU Negative regulator of flagellin synthesis
HICBILPI_00384 8.9e-81 flgN NOU FlgN protein
HICBILPI_00385 1.4e-273 flgK N flagellar hook-associated protein
HICBILPI_00386 2.3e-162 flgL N Belongs to the bacterial flagellin family
HICBILPI_00387 8.9e-80 yviE
HICBILPI_00388 7.2e-74 fliW S Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HICBILPI_00389 2.3e-31 csrA T Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HICBILPI_00390 3.2e-101 fliC N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HICBILPI_00391 2e-243 fliD N morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HICBILPI_00392 3e-66 fliS N flagellar protein FliS
HICBILPI_00393 3.5e-10 fliT S bacterial-type flagellum organization
HICBILPI_00394 6.8e-68
HICBILPI_00395 3.7e-102 hpf J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HICBILPI_00396 9.6e-41 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
HICBILPI_00397 0.0 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
HICBILPI_00398 1.4e-176 prfB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HICBILPI_00399 1.3e-148 yvjA S Uncharacterized protein conserved in bacteria (DUF2179)
HICBILPI_00400 6.2e-36 cccB C COG2010 Cytochrome c, mono- and diheme variants
HICBILPI_00401 2.3e-122 ftsE D cell division ATP-binding protein FtsE
HICBILPI_00402 1.2e-155 ftsX D Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation
HICBILPI_00403 4.3e-224 ywoF P Right handed beta helix region
HICBILPI_00404 2.4e-251 ctpB 3.4.21.102 M Belongs to the peptidase S41A family
HICBILPI_00405 1.5e-55 swrA S Swarming motility protein
HICBILPI_00406 1.8e-136 minJ O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HICBILPI_00407 4.2e-74 minJ O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HICBILPI_00408 1.1e-174 S Psort location CytoplasmicMembrane, score
HICBILPI_00409 9.6e-226 yvkA EGP Major facilitator Superfamily
HICBILPI_00410 2e-109 yvkB K Transcriptional regulator
HICBILPI_00411 0.0 yvkC 2.7.9.2 GT Phosphotransferase
HICBILPI_00412 7.6e-33 csbA S protein conserved in bacteria
HICBILPI_00413 0.0 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
HICBILPI_00414 0.0 uvrA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
HICBILPI_00415 2.2e-32 yvkN
HICBILPI_00416 6.1e-49 yvlA
HICBILPI_00417 1.2e-165 yvlB S Putative adhesin
HICBILPI_00418 9.6e-26 pspB KT PspC domain
HICBILPI_00419 1.5e-40 yvlD S Membrane
HICBILPI_00420 0.0 yvnB 3.1.4.53 Q Calcineurin-like phosphoesterase
HICBILPI_00421 5.1e-77 yvnB 3.1.4.53 Q Calcineurin-like phosphoesterase
HICBILPI_00422 4.4e-103 yxaF K Transcriptional regulator
HICBILPI_00423 2.3e-133 yvoA K transcriptional
HICBILPI_00424 1.8e-133 nagB 3.1.1.31, 3.5.99.6 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
HICBILPI_00425 3.4e-61 nagA 3.5.1.25 G Belongs to the metallo-dependent hydrolases superfamily. NagA family
HICBILPI_00426 1.8e-128 nagA 3.5.1.25 G Belongs to the metallo-dependent hydrolases superfamily. NagA family
HICBILPI_00427 1.5e-169 hprK F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HICBILPI_00428 6.4e-148 lgt 2.1.1.199 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HICBILPI_00429 5.3e-113 ppaX 3.1.3.18, 3.6.1.1 S Hydrolyzes pyrophosphate formed during P-Ser-HPr dephosphorylation by HPrK P. Might play a role in controlling the intracellular pyrophosphate pool
HICBILPI_00430 2.4e-79 yvoF S COG0110 Acetyltransferase (isoleucine patch superfamily)
HICBILPI_00431 3.5e-137 yvpB NU protein conserved in bacteria
HICBILPI_00432 1e-207 hisZ 2.4.2.17, 6.1.1.21 E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HICBILPI_00433 5.6e-115 hisG 2.4.2.17 E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
HICBILPI_00434 1.4e-232 hisD 1.1.1.23, 1.1.1.308 E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HICBILPI_00435 6.7e-107 hisB 1.1.1.23, 2.6.1.9, 3.1.3.15, 4.2.1.19 E imidazoleglycerol-phosphate dehydratase
HICBILPI_00436 1.6e-114 hisH E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HICBILPI_00437 1.3e-128 hisA 5.3.1.16 E 1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HICBILPI_00438 4.9e-134 hisF E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
HICBILPI_00439 1.8e-110 hisE 3.5.4.19, 3.6.1.31, 5.3.1.16 E belongs to the PRA-CH family
HICBILPI_00440 0.0 msbA2 3.6.3.44 V ABC transporter
HICBILPI_00441 6.8e-54
HICBILPI_00442 9.5e-121 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HICBILPI_00443 2.3e-190 sasA T Histidine kinase
HICBILPI_00444 2.5e-275 S COG0457 FOG TPR repeat
HICBILPI_00445 1.3e-124 usp CBM50 M protein conserved in bacteria
HICBILPI_00446 3.5e-177 trxB 1.8.1.9 C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
HICBILPI_00447 6.5e-87 yvcI 3.6.1.55 F COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
HICBILPI_00448 1.1e-166 rapZ S Displays ATPase and GTPase activities
HICBILPI_00449 1.7e-176 ybhK S Required for morphogenesis under gluconeogenic growth conditions
HICBILPI_00450 5.3e-170 whiA K May be required for sporulation
HICBILPI_00451 4.7e-36 crh G Phosphocarrier protein Chr
HICBILPI_00452 5.7e-143 nhoA 2.3.1.118 Q Belongs to the arylamine N-acetyltransferase family
HICBILPI_00453 8.2e-79 M Ribonuclease
HICBILPI_00454 2.3e-181 ghrB 1.1.1.215, 1.1.1.26, 1.1.1.43, 1.1.1.79, 1.1.1.81 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HICBILPI_00455 7.4e-106 ytiB 4.2.1.1 P Reversible hydration of carbon dioxide
HICBILPI_00456 7.3e-281 sulP P COG0659 Sulfate permease and related transporters (MFS superfamily)
HICBILPI_00457 6.8e-53 yvdC S MazG nucleotide pyrophosphohydrolase domain
HICBILPI_00458 9.6e-106 yvdD 3.2.2.10 S Belongs to the LOG family
HICBILPI_00459 5.3e-11 yvdD 3.2.2.10 S Belongs to the LOG family
HICBILPI_00460 9.2e-248 EGP Sugar (and other) transporter
HICBILPI_00461 1.4e-209 yraM S PrpF protein
HICBILPI_00462 6.7e-164 yraN K Transcriptional regulator
HICBILPI_00463 2.4e-104 clpP 3.4.21.92 OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
HICBILPI_00464 5.6e-183 scrR K transcriptional
HICBILPI_00465 5.2e-218 rafB P LacY proton/sugar symporter
HICBILPI_00466 1.2e-290 cscA 3.2.1.26, 3.2.1.65 GH32 G invertase
HICBILPI_00468 2.6e-33
HICBILPI_00469 4.9e-268 I Pfam Lipase (class 3)
HICBILPI_00470 9.8e-18 S Protein of unknown function (DUF1433)
HICBILPI_00471 7.7e-18 S Protein of unknown function (DUF1433)
HICBILPI_00473 7.7e-16 S Protein of unknown function (DUF1433)
HICBILPI_00474 1.6e-93 padC Q Phenolic acid decarboxylase
HICBILPI_00475 2.3e-90 paiA 2.3.1.57 K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HICBILPI_00476 2.2e-111 yyaS S Membrane
HICBILPI_00477 3.7e-96 ywjB H RibD C-terminal domain
HICBILPI_00479 3.8e-284 pnbA CE10 I Belongs to the type-B carboxylesterase lipase family
HICBILPI_00480 2e-39 slr K transcriptional
HICBILPI_00481 3.5e-118 ywqC M biosynthesis protein
HICBILPI_00482 5.4e-116 epsB 2.7.10.2 D COG0489 ATPases involved in chromosome partitioning
HICBILPI_00483 0.0 pglF 4.2.1.115, 4.2.1.135, 4.2.1.46 GM Polysaccharide biosynthesis protein
HICBILPI_00484 9.1e-217 epsD GT4 M Glycosyl transferase 4-like
HICBILPI_00485 2.6e-160 epsE GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
HICBILPI_00486 4.7e-213 epsF GT4 M Glycosyl transferases group 1
HICBILPI_00487 7.7e-205 epsG S EpsG family
HICBILPI_00488 1.9e-192 epsH GT2 S Glycosyltransferase like family 2
HICBILPI_00489 1.2e-202 epsI GM pyruvyl transferase
HICBILPI_00490 7.5e-194 epsJ GT2 S COG0463 Glycosyltransferases involved in cell wall biogenesis
HICBILPI_00491 2.8e-30 pglK S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
HICBILPI_00492 1.6e-222 pglK S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
HICBILPI_00493 6.3e-108 epsL M COG2148 Sugar transferases involved in lipopolysaccharide synthesis
HICBILPI_00494 4.2e-49 epsM GM COG0110 Acetyltransferase (isoleucine patch superfamily)
HICBILPI_00495 4.1e-220 epsN 2.6.1.102 E Belongs to the DegT DnrJ EryC1 family
HICBILPI_00496 9.2e-186 yvfF GM Exopolysaccharide biosynthesis protein
HICBILPI_00497 2.7e-32 yvfG S YvfG protein
HICBILPI_00498 1.4e-242 rpoN K COG1508 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog
HICBILPI_00499 3.8e-304 yvfH C L-lactate permease
HICBILPI_00500 1.5e-119 yvfI K COG2186 Transcriptional regulators
HICBILPI_00501 1.3e-218 EK COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
HICBILPI_00502 1.1e-135 lutA C Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source
HICBILPI_00503 1.1e-270 lutB C Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source. Has probably a role as an electron transporter during oxidation of L-lactate
HICBILPI_00504 1.8e-42 lutC S Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source
HICBILPI_00505 5e-69 lutC S Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source
HICBILPI_00506 9.6e-210 gntP EG COG2610 H gluconate symporter and related permeases
HICBILPI_00507 3.2e-297 gntK 2.7.1.12, 2.7.1.17, 2.7.1.189 G Belongs to the FGGY kinase family
HICBILPI_00508 5e-151 ybbH_1 K RpiR family transcriptional regulator
HICBILPI_00510 1.1e-213 yvbW E COG1113 Gamma-aminobutyrate permease and related permeases
HICBILPI_00511 2.5e-156 yvbV EG EamA-like transporter family
HICBILPI_00512 1.5e-155 yvbU K Transcriptional regulator
HICBILPI_00514 3.2e-189 yvbT C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HICBILPI_00515 5.5e-203 araR K transcriptional
HICBILPI_00516 5.1e-91 araE EGP Major facilitator Superfamily
HICBILPI_00517 2.4e-108 araE EGP Major facilitator Superfamily
HICBILPI_00519 2.3e-187 cggR K COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain
HICBILPI_00520 2.1e-185 gapA 1.2.1.12 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
HICBILPI_00521 1.7e-218 pgk 2.7.2.3, 5.3.1.1 F Belongs to the phosphoglycerate kinase family
HICBILPI_00522 6.6e-139 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
HICBILPI_00523 9.8e-299 gpmI 5.4.2.12 G Catalyzes the interconversion of 2-phosphoglycerate and
HICBILPI_00524 6.4e-243 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
HICBILPI_00525 4.9e-235 ywaD 3.4.11.10, 3.4.11.6 S PA domain
HICBILPI_00526 8.9e-256 1.1.1.136 M Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HICBILPI_00527 2.6e-216 spsC 2.6.1.102 E Belongs to the DegT DnrJ EryC1 family
HICBILPI_00528 2e-169 5.1.3.2 M GDP-mannose 4,6 dehydratase
HICBILPI_00529 8.5e-224 E UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HICBILPI_00530 4.6e-147 M Protein involved in cellulose biosynthesis
HICBILPI_00531 2.1e-142 C WbqC-like protein family
HICBILPI_00532 7e-124 S GlcNAc-PI de-N-acetylase
HICBILPI_00533 3.3e-177
HICBILPI_00534 1.8e-210 EGP Major facilitator Superfamily
HICBILPI_00535 2.1e-79 yvbK 3.1.3.25 K acetyltransferase
HICBILPI_00536 0.0 tcaA S response to antibiotic
HICBILPI_00537 6.4e-120 exoY M Membrane
HICBILPI_00538 9.8e-104 yvbG U UPF0056 membrane protein
HICBILPI_00539 3.5e-97 yvbF K Belongs to the GbsR family
HICBILPI_00540 6.7e-212 opuCA 3.6.3.32 E COG1125 ABC-type proline glycine betaine transport systems, ATPase components
HICBILPI_00541 4.5e-112 opuCB P COG1174 ABC-type proline glycine betaine transport systems, permease component
HICBILPI_00542 5.5e-172 opuCC M COG1732 Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
HICBILPI_00543 2.8e-109 opuCD P COG1174 ABC-type proline glycine betaine transport systems, permease component
HICBILPI_00544 4.3e-76 yvbF K Belongs to the GbsR family
HICBILPI_00545 8.6e-207 opuCA 3.6.3.32 E COG1125 ABC-type proline glycine betaine transport systems, ATPase components
HICBILPI_00546 3e-102 opuCB P COG1174 ABC-type proline glycine betaine transport systems, permease component
HICBILPI_00547 3e-170 opuCC M COG1732 Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
HICBILPI_00548 3.6e-112 opuCD P COG1174 ABC-type proline glycine betaine transport systems, permease component
HICBILPI_00549 4.5e-124 mutF V ABC transporter, ATP-binding protein
HICBILPI_00550 4.9e-123 spaE S ABC-2 family transporter protein
HICBILPI_00551 3.1e-136 mutG S ABC-2 family transporter protein
HICBILPI_00552 1.4e-121 K Transcriptional regulatory protein, C terminal
HICBILPI_00553 1.5e-258 T His Kinase A (phosphoacceptor) domain
HICBILPI_00554 8.8e-53 yodB K transcriptional
HICBILPI_00555 1e-72 yvaO K Cro/C1-type HTH DNA-binding domain
HICBILPI_00556 1e-69 K transcriptional
HICBILPI_00557 6e-35 yvzC K Transcriptional
HICBILPI_00558 4.8e-24 secG U Preprotein translocase subunit SecG
HICBILPI_00559 1.6e-142 est 3.1.1.1 S Carboxylesterase
HICBILPI_00560 0.0 rnr K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
HICBILPI_00561 1.6e-82 smpB O Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HICBILPI_00563 3.7e-48 yrdF K ribonuclease inhibitor
HICBILPI_00564 6.9e-139 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
HICBILPI_00565 2.5e-161 ytlI K LysR substrate binding domain
HICBILPI_00566 3e-101 ytmI K Acetyltransferase (GNAT) domain
HICBILPI_00567 4.3e-128 ytmJ ET Bacterial periplasmic substrate-binding proteins
HICBILPI_00568 4.3e-144 tcyK M Bacterial periplasmic substrate-binding proteins
HICBILPI_00569 1.7e-120 tcyL P Binding-protein-dependent transport system inner membrane component
HICBILPI_00570 1.9e-119 tcyM U Binding-protein-dependent transport system inner membrane component
HICBILPI_00571 3.6e-140 tcyN 3.6.3.21 E COG1126 ABC-type polar amino acid transport system, ATPase component
HICBILPI_00572 2.1e-180 ytmO C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HICBILPI_00573 2.5e-46 ytnI O COG0695 Glutaredoxin and related proteins
HICBILPI_00574 2e-252 moxC C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HICBILPI_00575 2.5e-118 azoR I Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HICBILPI_00576 4.6e-191 yvaA 1.1.1.371 S Oxidoreductase
HICBILPI_00577 1.4e-47 csoR S transcriptional
HICBILPI_00578 7.6e-29 copZ P Heavy-metal-associated domain
HICBILPI_00579 0.0 copA 3.6.3.54 P P-type ATPase
HICBILPI_00580 0.0 cadA 3.6.3.3, 3.6.3.5 P COG2217 Cation transport ATPase
HICBILPI_00581 7.5e-102 bdbD O Thioredoxin
HICBILPI_00582 5.6e-71 bdbC O Required for disulfide bond formation in some proteins
HICBILPI_00583 1.7e-140 S Metallo-peptidase family M12
HICBILPI_00584 2.9e-97 yvgT S membrane
HICBILPI_00585 0.0 helD 3.6.4.12 L DNA helicase
HICBILPI_00586 0.0 cysJ 1.8.1.2 P Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HICBILPI_00587 0.0 cysI 1.7.7.1, 1.8.1.2, 1.8.7.1 P Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate
HICBILPI_00588 0.0 yjcE P COG0025 NhaP-type Na H and K H antiporters
HICBILPI_00589 2.7e-85 yvgO
HICBILPI_00590 5e-156 yvgN S reductase
HICBILPI_00591 7e-193 yfiN V COG0842 ABC-type multidrug transport system, permease component
HICBILPI_00592 7.5e-162 yfiM V ABC-2 type transporter
HICBILPI_00593 2.1e-171 yfiL V COG1131 ABC-type multidrug transport system, ATPase component
HICBILPI_00594 1.6e-178 T Histidine kinase
HICBILPI_00595 8.6e-114 yfiK K Regulator
HICBILPI_00596 7.9e-99 modB P COG4149 ABC-type molybdate transport system, permease component
HICBILPI_00597 2.6e-138 modA P COG0725 ABC-type molybdate transport system, periplasmic component
HICBILPI_00598 2.3e-165 yvgK P COG1910 Periplasmic molybdate-binding protein domain
HICBILPI_00599 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
HICBILPI_00600 1.7e-84 yvsG S LexA-binding, inner membrane-associated putative hydrolase
HICBILPI_00601 5.2e-13 S Small spore protein J (Spore_SspJ)
HICBILPI_00602 7e-235 yvsH E Arginine ornithine antiporter
HICBILPI_00603 1.6e-126 Q Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HICBILPI_00604 2.6e-177 fhuD P ABC transporter
HICBILPI_00605 1.6e-183 fhuB P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HICBILPI_00606 7.6e-175 fhuG P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HICBILPI_00607 1.4e-147 fhuC 3.6.3.34 HP ABC transporter
HICBILPI_00608 9.3e-66 yvrL S Regulatory protein YrvL
HICBILPI_00609 3e-231 oxdC 4.1.1.2 G Oxalate decarboxylase
HICBILPI_00610 1.6e-15 S YvrJ protein family
HICBILPI_00611 3.8e-102 yvrI K RNA polymerase
HICBILPI_00612 1.1e-36
HICBILPI_00613 2.6e-132 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HICBILPI_00614 0.0 T PhoQ Sensor
HICBILPI_00615 4.2e-169 yvrE G SMP-30/Gluconolaconase/LRE-like region
HICBILPI_00616 1.4e-139 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
HICBILPI_00617 4.6e-166 yvrC P ABC transporter substrate-binding protein
HICBILPI_00618 7.5e-142 btuC P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HICBILPI_00619 2.3e-218 yvrA 3.6.3.34 HP COG1120 ABC-type cobalamin Fe3 -siderophores transport systems, ATPase components
HICBILPI_00620 1.4e-101 yvqK 2.5.1.17 S Adenosyltransferase
HICBILPI_00621 1.8e-226 yvqJ EGP Major facilitator Superfamily
HICBILPI_00622 5.3e-44 liaI S membrane
HICBILPI_00623 1.5e-89 liaH KT COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription
HICBILPI_00624 7.4e-126 liaG S Putative adhesin
HICBILPI_00625 8.6e-128 yvqF S Cell wall-active antibiotics response 4TMS YvqF
HICBILPI_00626 8.7e-193 vraS 2.7.13.3 T Histidine kinase
HICBILPI_00627 5.6e-107 vraR KT COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HICBILPI_00628 6e-205 gerAC S Spore germination B3/ GerAC like, C-terminal
HICBILPI_00629 3.6e-186 gerAB E Spore germination protein
HICBILPI_00630 3.5e-258 gerAA EG Spore germination protein
HICBILPI_00631 6.6e-24 S Protein of unknown function (DUF3970)
HICBILPI_00632 1.5e-261 fumC 1.1.1.38, 4.2.1.2 C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
HICBILPI_00633 3.2e-156 yuxN K Transcriptional regulator
HICBILPI_00634 3.4e-24
HICBILPI_00635 9.7e-250 cssS 2.7.13.3 T PhoQ Sensor
HICBILPI_00636 2.6e-126 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HICBILPI_00637 3.8e-238 htrA 3.4.21.107 O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HICBILPI_00638 4.7e-79 dps P Belongs to the Dps family
HICBILPI_00639 1.1e-147 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
HICBILPI_00640 0.0 pepF2 E COG1164 Oligoendopeptidase F
HICBILPI_00641 3.2e-45 S YusW-like protein
HICBILPI_00642 3.1e-150 yusV 3.6.3.34 HP ABC transporter
HICBILPI_00643 3.3e-39 yusU S Protein of unknown function (DUF2573)
HICBILPI_00644 2.4e-184 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HICBILPI_00645 4.2e-138 adc 4.1.1.4 Q Acetoacetate decarboxylase (ADC)
HICBILPI_00646 1e-154 ywbI2 K Transcriptional regulator
HICBILPI_00647 8.1e-288 yusP P Major facilitator superfamily
HICBILPI_00648 5.7e-69 yusO K Iron dependent repressor, N-terminal DNA binding domain
HICBILPI_00649 1.1e-53 yusN M Coat F domain
HICBILPI_00650 5.7e-42
HICBILPI_00651 8.9e-210 yusP P Major facilitator superfamily
HICBILPI_00652 1.4e-164 fadM E Proline dehydrogenase
HICBILPI_00653 0.0 fadB 1.1.1.35, 4.2.1.17, 5.1.2.3 I 3-hydroxyacyl-CoA dehydrogenase
HICBILPI_00654 4.2e-217 fadA 2.3.1.16 I Belongs to the thiolase family
HICBILPI_00655 0.0 fadE 1.3.8.1 I acyl-CoA dehydrogenase
HICBILPI_00656 2.1e-63 arsC 1.20.4.1 P Belongs to the ArsC family
HICBILPI_00657 2.4e-65 gcvH E Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate
HICBILPI_00658 3.7e-40 yusG S Protein of unknown function (DUF2553)
HICBILPI_00659 4.9e-63 rnmV 3.1.26.8 L COG1658 Small primase-like proteins (Toprim domain)
HICBILPI_00660 1.6e-54 yusE CO Thioredoxin
HICBILPI_00661 1.5e-56 yusD S SCP-2 sterol transfer family
HICBILPI_00662 4.8e-185 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HICBILPI_00663 1.8e-95 metI P COG2011 ABC-type metal ion transport system, permease component
HICBILPI_00664 3e-145 metQ P Belongs to the NlpA lipoprotein family
HICBILPI_00665 3.8e-63 yurZ 2.3.1.12, 4.1.1.44 S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HICBILPI_00666 2.3e-142 sufC O COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component
HICBILPI_00667 1.2e-244 sufD O assembly protein SufD
HICBILPI_00668 2.1e-235 sufS 2.8.1.7, 4.4.1.16 E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HICBILPI_00669 8.5e-78 nifU C COG0822 NifU homolog involved in Fe-S cluster formation
HICBILPI_00670 8.7e-270 sufB O FeS cluster assembly
HICBILPI_00671 1.7e-156 csn 3.2.1.132 M Aids in the defense against invading fungal pathogens by degrading their cell wall chitosan
HICBILPI_00672 3.1e-201 yurR 1.4.5.1 E COG0665 Glycine D-amino acid oxidases (deaminating)
HICBILPI_00673 7e-65 yurQ 2.7.7.7 L COG0322 Nuclease subunit of the excinuclease complex
HICBILPI_00675 5e-165 K helix_turn_helix, mercury resistance
HICBILPI_00676 2.7e-185 frlB M Catalyzes the conversion of a range of fructosamine 6- phosphates to glucose 6-phosphate and a free amino acid
HICBILPI_00677 1.8e-167 yurO G COG1653 ABC-type sugar transport system, periplasmic component
HICBILPI_00678 1.2e-158 yurN G Binding-protein-dependent transport system inner membrane component
HICBILPI_00679 1.4e-164 yurM P COG0395 ABC-type sugar transport system, permease component
HICBILPI_00680 5e-146 yurL 2.7.1.218 G pfkB family carbohydrate kinase
HICBILPI_00681 3.6e-134 yurK K UTRA
HICBILPI_00682 2e-205 msmX P Belongs to the ABC transporter superfamily
HICBILPI_00683 1.6e-165 bsn L Ribonuclease
HICBILPI_00684 5.2e-234 pucF 3.5.1.6, 3.5.1.87, 3.5.3.9 E COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases
HICBILPI_00685 1.3e-235 pucG 2.6.1.112, 2.6.1.44, 2.6.1.45, 2.6.1.51 E COG0075 Serine-pyruvate aminotransferase archaeal aspartate aminotransferase
HICBILPI_00686 1.9e-212 blt EGP Major facilitator Superfamily
HICBILPI_00688 3.2e-08 S Phage Mu protein F like protein
HICBILPI_00690 2.2e-301 pucR QT COG2508 Regulator of polyketide synthase expression
HICBILPI_00691 4.7e-260 allB 3.5.2.5 F Catalyzes the conversion of allantoin (5- ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring
HICBILPI_00692 1.1e-59 3.1.3.18, 3.8.1.2 S phosphoglycolate phosphatase activity
HICBILPI_00693 1.2e-168 yunF S Protein of unknown function DUF72
HICBILPI_00694 1.1e-144 yunE S membrane transporter protein
HICBILPI_00695 6e-263 yunD 3.1.3.5 F Belongs to the 5'-nucleotidase family
HICBILPI_00696 3.3e-130 yunB S Sporulation protein YunB (Spo_YunB)
HICBILPI_00697 6.6e-192 lytH M Peptidase, M23
HICBILPI_00698 8e-168 lipA 2.8.1.8 H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HICBILPI_00699 1.7e-47 yutD S protein conserved in bacteria
HICBILPI_00700 6.8e-72 yutE S Protein of unknown function DUF86
HICBILPI_00701 1.4e-139 nagD 2.7.1.25, 3.1.3.41 G Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
HICBILPI_00702 8.7e-85 pgpA 3.1.3.27 I COG1267 Phosphatidylglycerophosphatase A and related proteins
HICBILPI_00703 3e-195 yutH S Spore coat protein
HICBILPI_00704 1.7e-163 hom 1.1.1.3 E homoserine dehydrogenase
HICBILPI_00705 3e-66 hom 1.1.1.3 E homoserine dehydrogenase
HICBILPI_00706 1.7e-196 thrC 4.2.3.1 E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HICBILPI_00707 9.8e-169 thrB 2.7.1.39 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
HICBILPI_00708 2e-199 yuxL 3.4.14.5, 3.4.19.1 EU peptidase
HICBILPI_00709 3e-124 yuxL 3.4.14.5, 3.4.19.1 EU peptidase
HICBILPI_00710 1.2e-35 yutI O COG0694 Thioredoxin-like proteins and domains
HICBILPI_00711 1.1e-53 yuzD S protein conserved in bacteria
HICBILPI_00712 5.5e-208 yutJ 1.6.99.3 C NADH dehydrogenase
HICBILPI_00713 2.4e-39 yuzB S Belongs to the UPF0349 family
HICBILPI_00714 5e-213 yutK F Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HICBILPI_00715 2.2e-162 dapF 5.1.1.7 E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HICBILPI_00716 1.1e-62 erpA S Belongs to the HesB IscA family
HICBILPI_00717 2.4e-136 dltE M Belongs to the short-chain dehydrogenases reductases (SDR) family
HICBILPI_00718 3.9e-26 K helix_turn_helix, mercury resistance
HICBILPI_00720 2.2e-33 S Bacteriocin class IId cyclical uberolysin-like
HICBILPI_00722 1.5e-121 V ABC transporter
HICBILPI_00723 1e-69 CP Membrane
HICBILPI_00724 4.8e-29
HICBILPI_00725 5.1e-184 guaC 1.1.1.205, 1.7.1.7 F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
HICBILPI_00727 5e-187 yumC 1.18.1.2, 1.19.1.1 C reductase
HICBILPI_00728 1.1e-236 yumB 1.6.99.3 C NADH dehydrogenase
HICBILPI_00729 9.9e-28 yuiB S Putative membrane protein
HICBILPI_00730 2.7e-117 yuiC S protein conserved in bacteria
HICBILPI_00731 1.6e-77 yuiD S protein conserved in bacteria
HICBILPI_00732 6.8e-281 pepA 3.4.11.1, 3.4.11.5 E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HICBILPI_00733 1.2e-207 yuiF S antiporter
HICBILPI_00734 5.6e-101 bioY S Biotin biosynthesis protein
HICBILPI_00735 3.2e-120 yuiH S Oxidoreductase molybdopterin binding domain
HICBILPI_00736 1.5e-163 besA S Putative esterase
HICBILPI_00737 4.8e-132 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
HICBILPI_00738 1.9e-220 entC 5.4.4.2 HQ Isochorismate synthase
HICBILPI_00739 9.3e-215 entE 2.7.7.58, 6.3.2.14 Q 2,3-dihydroxybenzoate-AMP ligase
HICBILPI_00740 3.6e-171 entB 3.3.2.1, 6.3.2.14 Q Isochorismatase family
HICBILPI_00741 0.0 dhbF Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HICBILPI_00742 1.1e-33 mbtH S MbtH-like protein
HICBILPI_00743 4.1e-132 yukJ S Uncharacterized conserved protein (DUF2278)
HICBILPI_00744 1e-204 ald 1.4.1.1 E Belongs to the AlaDH PNT family
HICBILPI_00745 4.2e-228 yukF QT Transcriptional regulator
HICBILPI_00746 3.3e-46 esxA S Belongs to the WXG100 family
HICBILPI_00747 3.9e-40 yukD S WXG100 protein secretion system (Wss), protein YukD
HICBILPI_00748 1.2e-204 essB S WXG100 protein secretion system (Wss), protein YukC
HICBILPI_00749 5.8e-161 essC D COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins
HICBILPI_00750 0.0 essC D COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins
HICBILPI_00751 0.0 esaA S type VII secretion protein EsaA
HICBILPI_00752 1.3e-76 yueC S Family of unknown function (DUF5383)
HICBILPI_00753 1.4e-130 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HICBILPI_00754 8.3e-96 yueE S phosphohydrolase
HICBILPI_00755 1.6e-22 S Protein of unknown function (DUF2642)
HICBILPI_00756 2.1e-186 yueF S transporter activity
HICBILPI_00757 6.4e-34 yueG S Spore germination protein gerPA/gerPF
HICBILPI_00758 2.8e-38 yueH S YueH-like protein
HICBILPI_00759 7.2e-68 yueI S Protein of unknown function (DUF1694)
HICBILPI_00760 1.1e-103 pncA Q COG1335 Amidases related to nicotinamidase
HICBILPI_00761 7.2e-283 pncB 6.3.4.21 H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HICBILPI_00762 3.8e-229 yuxH 3.1.4.52 T signal transduction protein containing EAL and modified HD-GYP domains
HICBILPI_00763 1.2e-50 yuzC
HICBILPI_00766 4.4e-62 comQ H Polyprenyl synthetase
HICBILPI_00768 5.3e-256 comP 2.7.13.3 T Histidine kinase
HICBILPI_00769 1.8e-113 comA K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HICBILPI_00770 1.1e-62 ydiI Q protein, possibly involved in aromatic compounds catabolism
HICBILPI_00771 5.2e-60 phaG P COG1320 Multisubunit Na H antiporter, MnhG subunit
HICBILPI_00772 1.9e-38 phaF P Subunit F of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
HICBILPI_00773 8.5e-76 mrpE P Subunit E of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
HICBILPI_00774 4.5e-264 mrpD CP Subunit D of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
HICBILPI_00775 8.9e-51 phaC 1.6.5.3 P Subunit C of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
HICBILPI_00776 3.5e-68 mrpB P Subunit B of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
HICBILPI_00777 0.0 phaA 1.6.5.3 CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit
HICBILPI_00778 2.3e-12
HICBILPI_00779 1.6e-169 yufQ S Belongs to the binding-protein-dependent transport system permease family
HICBILPI_00780 4.1e-122 yufP S Belongs to the binding-protein-dependent transport system permease family
HICBILPI_00781 1.3e-47 yufP S Belongs to the binding-protein-dependent transport system permease family
HICBILPI_00782 2.8e-285 xylG 3.6.3.17 S ABC transporter, ATP-binding protein
HICBILPI_00783 1.7e-193 tcsA S ABC-type transport system, periplasmic component surface lipoprotein
HICBILPI_00784 2.7e-126 dcuR T COG4565 Response regulator of citrate malate metabolism
HICBILPI_00785 3.8e-293 dcuS 2.7.13.3 T Signal transduction histidine kinase regulating citrate malate metabolism
HICBILPI_00786 2.7e-73 yufK S Family of unknown function (DUF5366)
HICBILPI_00787 1.2e-49 yuxK S protein conserved in bacteria
HICBILPI_00788 0.0 mrcB 2.4.1.129, 3.4.16.4 GT51 M Penicillin-binding Protein
HICBILPI_00789 1.1e-63 yuxJ EGP Major facilitator Superfamily
HICBILPI_00790 8.1e-112 yuxJ EGP Major facilitator Superfamily
HICBILPI_00791 4e-118 kapD L the KinA pathway to sporulation
HICBILPI_00792 7.7e-67 kapB G Kinase associated protein B
HICBILPI_00793 8.9e-229 T PhoQ Sensor
HICBILPI_00794 3.3e-222 patB 4.4.1.8 E COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
HICBILPI_00795 1.4e-40 yugE S Domain of unknown function (DUF1871)
HICBILPI_00796 5.5e-155 yugF I Hydrolase
HICBILPI_00797 2e-83 alaR K Transcriptional regulator
HICBILPI_00798 1.6e-208 yugH 2.6.1.1 E Aminotransferase
HICBILPI_00799 2.9e-61 yugI 5.3.1.9 J RNA binding protein (contains ribosomal protein S1 domain)
HICBILPI_00800 1.8e-34 yuzA S Domain of unknown function (DUF378)
HICBILPI_00801 1.4e-225 yugJ C oxidoreductases, Fe-dependent alcohol dehydrogenase family
HICBILPI_00802 1.8e-228 yugK C Dehydrogenase
HICBILPI_00803 3.5e-117 ycaC Q Isochorismatase family
HICBILPI_00804 3.6e-45 S NADPH-dependent FMN reductase
HICBILPI_00805 8.7e-259 pgi 5.3.1.9 G Belongs to the GPI family
HICBILPI_00807 7e-71 yugN S YugN-like family
HICBILPI_00808 5.3e-181 yugO P COG1226 Kef-type K transport systems
HICBILPI_00809 6.7e-27 mstX S Membrane-integrating protein Mistic
HICBILPI_00810 3.4e-18
HICBILPI_00811 8.3e-117 yugP S Zn-dependent protease
HICBILPI_00812 2.5e-231 yugS S COG1253 Hemolysins and related proteins containing CBS domains
HICBILPI_00813 0.0 yugT 3.2.1.10, 3.2.1.20 GH13,GH31 G COG0366 Glycosidases
HICBILPI_00814 2e-73 yugU S Uncharacterised protein family UPF0047
HICBILPI_00815 5.6e-189 yrpB 1.13.12.16 S COG2070 Dioxygenases related to 2-nitropropane dioxygenase
HICBILPI_00816 1.4e-40
HICBILPI_00817 2.2e-139 tgl 2.3.2.13 S protein-glutamine gamma-glutamyltransferase activity
HICBILPI_00818 8.1e-221 mcpA NT chemotaxis protein
HICBILPI_00819 1.5e-235 mcpA NT chemotaxis protein
HICBILPI_00820 6e-224 mcpA NT chemotaxis protein
HICBILPI_00821 1.3e-234 mcpA NT chemotaxis protein
HICBILPI_00822 1.5e-97 pfpI 1.11.1.6, 3.5.1.124 S DJ-1/PfpI family
HICBILPI_00823 1.4e-184 ygjR S Oxidoreductase
HICBILPI_00824 2.9e-194 yubA S transporter activity
HICBILPI_00825 2.3e-145 uppP 3.6.1.27 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
HICBILPI_00827 2.4e-50 yjcN
HICBILPI_00828 1.4e-118 G Cupin
HICBILPI_00829 1.6e-216 hmp 1.14.12.17 C Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HICBILPI_00830 1.5e-144 NU Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
HICBILPI_00831 3.6e-120 ktrA P COG0569 K transport systems, NAD-binding component
HICBILPI_00832 7.9e-94 yuaB
HICBILPI_00833 8.6e-96 yuaC K Belongs to the GbsR family
HICBILPI_00834 1.6e-282 gbsA 1.2.1.8 C Belongs to the aldehyde dehydrogenase family
HICBILPI_00835 7.1e-228 gbsB 1.1.1.1 C alcohol dehydrogenase
HICBILPI_00836 2.7e-108 yuaD S MOSC domain
HICBILPI_00837 2e-72 yuaE S DinB superfamily
HICBILPI_00838 4.7e-83 yuaF OU Membrane protein implicated in regulation of membrane protease activity
HICBILPI_00839 1.7e-178 yuaG 3.4.21.72 S protein conserved in bacteria
HICBILPI_00840 1.5e-95 thiT S Thiamine transporter protein (Thia_YuaJ)
HICBILPI_00841 3.4e-39 S COG NOG14552 non supervised orthologous group
HICBILPI_00846 1.6e-08
HICBILPI_00853 1.3e-09
HICBILPI_00854 7.8e-08
HICBILPI_00863 6.5e-76 tspO T membrane
HICBILPI_00864 7e-130 dksA T COG1734 DnaK suppressor protein
HICBILPI_00865 6.1e-271 menF 5.4.4.2 HQ Isochorismate synthase
HICBILPI_00866 0.0 menD 2.2.1.9 H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HICBILPI_00867 4.7e-154 menH 4.2.99.20 S Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC)
HICBILPI_00868 2.1e-154 menB 4.1.3.36 H Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HICBILPI_00869 4.1e-278 menE 6.2.1.26 H Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily
HICBILPI_00870 1.6e-213 menC 4.2.1.113 H Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)
HICBILPI_00871 2e-23 S Domain of Unknown Function (DUF1540)
HICBILPI_00872 1.5e-186 cydB 1.10.3.14 C COG1294 Cytochrome bd-type quinol oxidase, subunit 2
HICBILPI_00873 1.5e-239 cydA 1.10.3.14 C oxidase, subunit
HICBILPI_00874 7.9e-41 rpmE2 J Ribosomal protein L31
HICBILPI_00875 3.6e-105 ytiB 4.2.1.1 P Reversible hydration of carbon dioxide
HICBILPI_00876 1.2e-38 yidD S Could be involved in insertion of integral membrane proteins into the membrane
HICBILPI_00877 5.7e-88 luxS 4.4.1.21 T Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
HICBILPI_00878 7.9e-76 ytkA S YtkA-like
HICBILPI_00880 1e-75 dps P Belongs to the Dps family
HICBILPI_00881 5e-61 ytkC S Bacteriophage holin family
HICBILPI_00882 9.8e-88 ytkD 3.6.1.55 L Belongs to the Nudix hydrolase family
HICBILPI_00883 8.1e-127 ytlD P COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component
HICBILPI_00884 3.2e-144 ytlC P ABC transporter
HICBILPI_00885 5.8e-183 ytlA P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components
HICBILPI_00886 5.2e-147 ytmA E COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases
HICBILPI_00887 1.6e-38 ytmB S Protein of unknown function (DUF2584)
HICBILPI_00888 7.7e-307 pckA 4.1.1.49 C Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HICBILPI_00889 1.5e-225 metK 2.5.1.6 H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HICBILPI_00890 0.0 asnB 6.3.5.4 E Asparagine synthase
HICBILPI_00891 1.1e-259 ytnA E COG1113 Gamma-aminobutyrate permease and related permeases
HICBILPI_00892 3.9e-22 ytoA S COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HICBILPI_00893 1.2e-17 ytoA S COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HICBILPI_00894 2.9e-150 ytpA 3.1.1.5 I Alpha beta hydrolase
HICBILPI_00895 7.1e-211 ytpB 4.2.3.130 S Tetraprenyl-beta-curcumene synthase
HICBILPI_00896 2.6e-141 glpQ 3.1.4.46, 5.4.2.11 C glycerophosphoryl diester phosphodiesterase
HICBILPI_00898 2.5e-106 ytqB J Putative rRNA methylase
HICBILPI_00899 1.1e-189 yhcC S Fe-S oxidoreductase
HICBILPI_00900 5.3e-282 norB EGP COG0477 Permeases of the major facilitator superfamily
HICBILPI_00901 6.8e-193 K helix_turn_helix, Arsenical Resistance Operon Repressor
HICBILPI_00902 7.4e-40 ytzC S Protein of unknown function (DUF2524)
HICBILPI_00904 3.9e-66 ytrA K GntR family transcriptional regulator
HICBILPI_00905 5.5e-161 ytrB P abc transporter atp-binding protein
HICBILPI_00906 2e-164 S ABC-2 family transporter protein
HICBILPI_00907 5.9e-172 P ABC-2 family transporter protein
HICBILPI_00908 1.2e-151
HICBILPI_00909 2.2e-125 ytrE V ABC transporter, ATP-binding protein
HICBILPI_00910 1.4e-221 ytrF V COG0577 ABC-type antimicrobial peptide transport system, permease component
HICBILPI_00911 2.8e-128 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HICBILPI_00912 6e-169 T PhoQ Sensor
HICBILPI_00913 1.4e-133 bceA V ABC transporter, ATP-binding protein
HICBILPI_00914 0.0 bceB V ABC transporter (permease)
HICBILPI_00915 1.4e-122 ywaF S Integral membrane protein
HICBILPI_00916 2.3e-207 yttB EGP Major facilitator Superfamily
HICBILPI_00917 3.8e-137 pfyP T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)
HICBILPI_00918 1.2e-52 ytvB S Protein of unknown function (DUF4257)
HICBILPI_00919 0.0 leuS 6.1.1.4 J Belongs to the class-I aminoacyl-tRNA synthetase family
HICBILPI_00920 5.6e-52 ytwF P Sulfurtransferase
HICBILPI_00921 1.7e-84 M Acetyltransferase (GNAT) domain
HICBILPI_00922 1e-248 melA 3.2.1.122, 3.2.1.22, 3.2.1.86 GH4,GT4 G Family 4 glycosyl hydrolase
HICBILPI_00923 4.1e-142 amyC P ABC transporter (permease)
HICBILPI_00924 1.6e-168 amyD G Binding-protein-dependent transport system inner membrane component
HICBILPI_00925 4.9e-243 msmE G Bacterial extracellular solute-binding protein
HICBILPI_00926 4.8e-185 msmR K Transcriptional regulator
HICBILPI_00927 9e-26 yteV S Sporulation protein Cse60
HICBILPI_00928 1.3e-282 opuD M Belongs to the BCCT transporter (TC 2.A.15) family
HICBILPI_00929 5.7e-236 ytfP S HI0933-like protein
HICBILPI_00930 1.7e-293 ytgP S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
HICBILPI_00931 5.3e-130 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
HICBILPI_00932 2.4e-33 ytzE K COG1349 Transcriptional regulators of sugar metabolism
HICBILPI_00933 3.7e-128 ythP V ABC transporter
HICBILPI_00934 4.6e-216 ythQ U Bacterial ABC transporter protein EcsB
HICBILPI_00935 1.3e-227 pbuO S permease
HICBILPI_00936 4e-267 pepV 3.5.1.18 E Dipeptidase
HICBILPI_00937 3.1e-173 ytkP 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
HICBILPI_00938 2.3e-101 ligT 3.1.4.58, 3.5.1.42 J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HICBILPI_00939 1.2e-166 ytlQ
HICBILPI_00940 4.4e-177 ytlR 2.7.1.91 I Diacylglycerol kinase catalytic domain
HICBILPI_00941 6.3e-156 ytmP 2.7.1.89 M Phosphotransferase
HICBILPI_00942 3.5e-45 ytzH S YtzH-like protein
HICBILPI_00943 8e-125 trmB 2.1.1.297, 2.1.1.33 J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
HICBILPI_00944 2.1e-162 ytnP S COG0491 Zn-dependent hydrolases, including glyoxylases
HICBILPI_00945 0.0 sfcA 1.1.1.38 C Malate dehydrogenase
HICBILPI_00946 1.7e-51 ytzB S small secreted protein
HICBILPI_00947 5.8e-205 pepA 3.4.11.7 G COG1363 Cellulase M and related proteins
HICBILPI_00948 3.2e-77 ytoQ S Nucleoside 2-deoxyribosyltransferase YtoQ
HICBILPI_00949 1.6e-57 ytpP 2.7.1.180, 5.3.4.1 CO Thioredoxin
HICBILPI_00950 3.7e-148 ytpQ S Belongs to the UPF0354 family
HICBILPI_00951 1.1e-107 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HICBILPI_00952 0.0 sftA D Belongs to the FtsK SpoIIIE SftA family
HICBILPI_00953 1.4e-250 mpl 6.3.2.4, 6.3.2.45, 6.3.2.8 M Belongs to the MurCDEF family
HICBILPI_00954 1.7e-14 ytxG S protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HICBILPI_00955 1.7e-16 ytxH S COG4980 Gas vesicle protein
HICBILPI_00956 2.5e-42 ytxJ O Protein of unknown function (DUF2847)
HICBILPI_00957 1.9e-195 aroF 2.5.1.54, 5.4.99.5 E Catalyzes the formation of 3-deoxy-D-aribino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate and the formation of prephenate from chorismate
HICBILPI_00958 6.4e-182 ccpA K catabolite control protein A
HICBILPI_00959 6.6e-145 motA N flagellar motor
HICBILPI_00960 1.1e-119 motS N Flagellar motor protein
HICBILPI_00961 4e-228 acuC BQ histone deacetylase
HICBILPI_00962 4.6e-117 acuB S Domain in cystathionine beta-synthase and other proteins.
HICBILPI_00963 7.2e-45 acuA K Part of the acuABC operon, which is possibly involved in the breakdown of acetoin and butanediol. Acts as an acetyltransferase inactivating acetyl-CoA synthetase AcsA via acetylation at a Lys residue
HICBILPI_00964 1.1e-56 acuA K Part of the acuABC operon, which is possibly involved in the breakdown of acetoin and butanediol. Acts as an acetyltransferase inactivating acetyl-CoA synthetase AcsA via acetylation at a Lys residue
HICBILPI_00965 0.0 acsA 6.2.1.1 I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases
HICBILPI_00966 3.6e-238 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HICBILPI_00967 2.1e-46 azlD S Branched-chain amino acid transport protein (AzlD)
HICBILPI_00968 5.2e-125 azlC E AzlC protein
HICBILPI_00969 2.8e-148 K Transcriptional regulator
HICBILPI_00970 1.1e-148 fieF P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HICBILPI_00971 2.6e-135 E GDSL-like Lipase/Acylhydrolase family
HICBILPI_00973 2.2e-90 yhbO 1.11.1.6, 3.5.1.124 S protease
HICBILPI_00974 2.5e-09
HICBILPI_00975 1.5e-217 hmp 1.14.12.17 C Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HICBILPI_00976 1.7e-99 yokH G SMI1 / KNR4 family
HICBILPI_00977 2.3e-251 ywdH 1.2.1.3 C Belongs to the aldehyde dehydrogenase family
HICBILPI_00978 2.5e-109 rpsD J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HICBILPI_00979 2.2e-232 ytrP 2.7.7.65 T COG2199 FOG GGDEF domain
HICBILPI_00980 4.6e-85 ytsP 1.8.4.14 T GAF domain-containing protein
HICBILPI_00981 1.7e-108 yttP K Transcriptional regulator
HICBILPI_00982 3e-153 hisK 3.1.3.15 E COG1387 Histidinol phosphatase and related hydrolases of the PHP family
HICBILPI_00983 2.1e-262 ezrA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HICBILPI_00984 8.5e-224 braB E Component of the transport system for branched-chain amino acids
HICBILPI_00985 2.3e-207 iscS2 2.8.1.7 E Cysteine desulfurase
HICBILPI_00986 2.8e-224 thiI 2.8.1.4 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HICBILPI_00987 3.9e-31 sspB S spore protein
HICBILPI_00988 4.2e-305 acsA 6.2.1.1, 6.2.1.2 I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases
HICBILPI_00989 8.8e-311 ytcJ S amidohydrolase
HICBILPI_00990 8.3e-151 nadK 2.7.1.23 G Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HICBILPI_00991 6.4e-182 sppA OU signal peptide peptidase SppA
HICBILPI_00992 4.5e-88 yteJ S RDD family
HICBILPI_00993 1e-93 ytfI S Protein of unknown function (DUF2953)
HICBILPI_00994 1.6e-60 ytfJ S Sporulation protein YtfJ
HICBILPI_00995 2.4e-89 tpx 1.11.1.15 O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HICBILPI_00996 9.1e-181 ytxK 2.1.1.72 L DNA methylase
HICBILPI_00997 7e-220 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HICBILPI_00998 1e-87 moaB 2.7.7.75 H May be involved in the biosynthesis of molybdopterin
HICBILPI_00999 1.5e-233 argG 6.3.4.5 E Belongs to the argininosuccinate synthase family. Type 1 subfamily
HICBILPI_01000 7e-264 argH 4.3.2.1 E argininosuccinate lyase
HICBILPI_01002 6.5e-142 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HICBILPI_01003 1.3e-128 ytkL S Belongs to the UPF0173 family
HICBILPI_01004 1.4e-23 ytoI K transcriptional regulator containing CBS domains
HICBILPI_01005 5.1e-193 ytoI K transcriptional regulator containing CBS domains
HICBILPI_01006 1.5e-46 ytpI S YtpI-like protein
HICBILPI_01007 2.1e-182 nrnA 3.1.13.3, 3.1.3.7 S COG0618 Exopolyphosphatase-related proteins
HICBILPI_01008 5.8e-23
HICBILPI_01009 4.3e-86 ytrI
HICBILPI_01010 3.2e-56 ytrH S Sporulation protein YtrH
HICBILPI_01011 0.0 dnaE 2.7.7.7 L DNA polymerase
HICBILPI_01012 2.9e-224 ytsJ 1.1.1.38 C Malate dehydrogenase
HICBILPI_01013 4.6e-160 accD 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HICBILPI_01014 5.3e-181 accA 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
HICBILPI_01015 2e-180 pfkA 2.7.1.11 F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
HICBILPI_01016 7.5e-295 pyk 2.7.1.40, 2.7.7.4 G Belongs to the pyruvate kinase family
HICBILPI_01017 3.5e-64 fxsA S COG3030 Protein affecting phage T7 exclusion by the F plasmid
HICBILPI_01018 2.4e-193 ytvI S sporulation integral membrane protein YtvI
HICBILPI_01019 1.1e-72 yeaL S membrane
HICBILPI_01020 2.1e-46 yjdF S Protein of unknown function (DUF2992)
HICBILPI_01021 2.8e-210 citZ 2.3.3.1 C Belongs to the citrate synthase family
HICBILPI_01022 1.2e-241 icd 1.1.1.42 C isocitrate
HICBILPI_01023 3.6e-171 mdh 1.1.1.37 C Catalyzes the reversible oxidation of malate to oxaloacetate
HICBILPI_01024 5.3e-130 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HICBILPI_01025 0.0 phoR 2.7.13.3 T Signal transduction histidine kinase
HICBILPI_01026 0.0 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HICBILPI_01027 9.1e-158 fpg 3.2.2.23, 4.2.99.18 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
HICBILPI_01028 2.1e-106 ytaF P Probably functions as a manganese efflux pump
HICBILPI_01029 2e-98 coaE 2.7.1.24 F Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HICBILPI_01030 1.7e-159 ytbE S reductase
HICBILPI_01031 4.5e-206 ytbD EGP Major facilitator Superfamily
HICBILPI_01032 2e-67 ytcD K Transcriptional regulator
HICBILPI_01033 9.7e-194 gapB 1.2.1.12, 1.2.1.59 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
HICBILPI_01034 1.5e-67 speH 4.1.1.50 E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HICBILPI_01035 4.2e-80 nrdR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HICBILPI_01036 3.1e-251 dnaB L Membrane attachment protein
HICBILPI_01037 9.5e-172 dnaI L Primosomal protein DnaI
HICBILPI_01038 2.1e-106 ytxB S SNARE associated Golgi protein
HICBILPI_01039 2e-152 ytxC S YtxC-like family
HICBILPI_01040 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HICBILPI_01041 3.9e-150 ysaA S HAD-hyrolase-like
HICBILPI_01042 0.0 lytS 2.7.13.3 T Histidine kinase
HICBILPI_01043 1.2e-129 lytT T COG3279 Response regulator of the LytR AlgR family
HICBILPI_01044 3.8e-38 lrgA S effector of murein hydrolase LrgA
HICBILPI_01045 5.4e-108 lrgB M Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses
HICBILPI_01046 1.5e-86 infC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HICBILPI_01047 3.1e-27 rpmI J Belongs to the bacterial ribosomal protein bL35 family
HICBILPI_01048 2.7e-58 rplT J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HICBILPI_01049 2.6e-42 ysdA S Membrane
HICBILPI_01050 1.9e-65 ysdB S Sigma-w pathway protein YsdB
HICBILPI_01051 8.1e-207 ysdC G COG1363 Cellulase M and related proteins
HICBILPI_01052 1.5e-188 abnA 3.2.1.99 GH43 G Belongs to the glycosyl hydrolase 43 family
HICBILPI_01053 4e-297 araA 5.3.1.4 G Catalyzes the conversion of L-arabinose to L-ribulose
HICBILPI_01054 0.0 araB 2.7.1.16 C Belongs to the ribulokinase family
HICBILPI_01055 4.2e-132 araD 4.1.2.17, 4.2.1.109, 5.1.3.4 G COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases
HICBILPI_01056 1.7e-140 araL 3.1.3.41 G Haloacid dehalogenase-like hydrolase
HICBILPI_01057 1.2e-224 egsA 1.1.1.261 I Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is probably used for the synthesis of phosphoglycerolipids in Gram-positive bacterial species
HICBILPI_01058 2.9e-251 araN G carbohydrate transport
HICBILPI_01059 6.4e-168 araP P PFAM binding-protein-dependent transport systems inner membrane component
HICBILPI_01060 1.2e-144 araQ G transport system permease
HICBILPI_01061 8.6e-300 abfA 3.2.1.55 GH51 G alpha-L-arabinofuranosidase activity
HICBILPI_01062 0.0 cstA T Carbon starvation protein
HICBILPI_01063 2e-255 glcF C Glycolate oxidase
HICBILPI_01064 1.6e-258 glcD 1.1.3.15 C FAD binding domain
HICBILPI_01065 2.7e-202 ysfB KT regulator
HICBILPI_01066 2e-32 sspI S Belongs to the SspI family
HICBILPI_01067 3.7e-134 spoU 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HICBILPI_01068 1e-195 pheS 6.1.1.20 J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HICBILPI_01069 0.0 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HICBILPI_01070 2.2e-168 rnhC 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HICBILPI_01071 2e-39 zapA D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HICBILPI_01072 1.8e-82 cvpA S membrane protein, required for colicin V production
HICBILPI_01073 0.0 polX L COG1796 DNA polymerase IV (family X)
HICBILPI_01074 0.0 mutS2 L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
HICBILPI_01075 4.7e-67 yshE S membrane
HICBILPI_01076 8.6e-89 ywbB S Protein of unknown function (DUF2711)
HICBILPI_01077 0.0 lcfA 6.2.1.3 IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
HICBILPI_01078 2.7e-103 fadR K Transcriptional regulator
HICBILPI_01079 5.4e-136 fadB 4.2.1.17 I Belongs to the enoyl-CoA hydratase isomerase family
HICBILPI_01080 2.8e-137 etfB C Electron transfer flavoprotein
HICBILPI_01081 1.6e-177 etfA C Electron transfer flavoprotein
HICBILPI_01082 8e-298 xsa 3.2.1.55 GH51 G Alpha-L-arabinofuranosidase C-terminus
HICBILPI_01083 2.5e-52 trxA O Belongs to the thioredoxin family
HICBILPI_01084 0.0 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
HICBILPI_01085 9.2e-215 lysC 1.1.1.3, 2.7.2.4 E Belongs to the aspartokinase family
HICBILPI_01086 2e-79 yslB S Protein of unknown function (DUF2507)
HICBILPI_01087 4.8e-108 sdhC C succinate dehydrogenase
HICBILPI_01088 0.0 sdhA 1.3.5.1, 1.3.5.4 C succinate dehydrogenase
HICBILPI_01089 1.3e-147 sdhB 1.3.5.1, 1.3.5.4 C succinate dehydrogenase
HICBILPI_01090 7.1e-77 ybgC 3.1.2.23, 3.1.2.28 S thioesterase
HICBILPI_01091 2e-30 gerE K Transcriptional regulator
HICBILPI_01092 7.4e-74 ysmB 2.4.2.28 K helix_turn_helix multiple antibiotic resistance protein
HICBILPI_01093 2.7e-154 murI 3.6.1.66, 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
HICBILPI_01094 5.3e-198 gerM S COG5401 Spore germination protein
HICBILPI_01095 3.4e-132 rph 2.7.7.56, 3.6.1.66 J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HICBILPI_01096 4.2e-101 rdgB 3.6.1.66 F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HICBILPI_01097 5.9e-91 ysnB S Phosphoesterase
HICBILPI_01102 0.0 ilvB 2.2.1.6 E Acetolactate synthase
HICBILPI_01103 2.1e-83 ilvN 2.2.1.6 E Acetolactate synthase
HICBILPI_01104 5.4e-192 ilvC 1.1.1.86 EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HICBILPI_01105 1.8e-287 leuA 2.3.3.13 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HICBILPI_01106 4.8e-199 leuB 1.1.1.85 CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
HICBILPI_01107 9.1e-275 leuC 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HICBILPI_01108 6.2e-116 leuD 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HICBILPI_01109 1e-187 ysoA H Tetratricopeptide repeat
HICBILPI_01110 4.7e-214 tig D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
HICBILPI_01111 3.8e-232 clpX O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HICBILPI_01112 1e-309 lonB 2.7.7.7, 3.4.21.53 LO Belongs to the peptidase S16 family
HICBILPI_01113 0.0 lon 3.4.21.53 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HICBILPI_01114 8.8e-107 engB D Necessary for normal cell division and for the maintenance of normal septation
HICBILPI_01115 3.8e-87 ysxD
HICBILPI_01116 3.8e-246 hemA 1.2.1.70 H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HICBILPI_01117 1e-145 hemX O cytochrome C
HICBILPI_01118 3.5e-174 hemC 2.1.1.107, 2.5.1.61, 4.2.1.75 H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
HICBILPI_01119 1.6e-140 hemD 2.1.1.107, 4.2.1.75 H Uroporphyrinogen-III synthase
HICBILPI_01120 3.9e-184 hemB 4.2.1.24 H Belongs to the ALAD family
HICBILPI_01121 2.8e-246 hemL 5.4.3.8 H Glutamate-1-semialdehyde aminotransferase
HICBILPI_01122 6.4e-223 spoVID M stage VI sporulation protein D
HICBILPI_01123 8.6e-198 ysxE S A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HICBILPI_01124 2.1e-25
HICBILPI_01125 0.0 valS 6.1.1.9 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
HICBILPI_01126 1.4e-237 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
HICBILPI_01127 1.1e-130 comC 3.4.23.43 NOU COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases
HICBILPI_01128 1.4e-136 spoIIB S Sporulation related domain
HICBILPI_01129 2.1e-97 maf D septum formation protein Maf
HICBILPI_01130 5.3e-127 radC E Belongs to the UPF0758 family
HICBILPI_01131 4e-184 mreB D Rod shape-determining protein MreB
HICBILPI_01132 3.6e-157 mreC M Involved in formation and maintenance of cell shape
HICBILPI_01133 5.4e-84 mreD M shape-determining protein
HICBILPI_01134 1.5e-97 minC D Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization
HICBILPI_01135 2.3e-142 minD D Belongs to the ParA family
HICBILPI_01136 1.7e-145 spoIVFA M COG0739 Membrane proteins related to metalloendopeptidases
HICBILPI_01137 4.6e-160 spoIVFB S Stage IV sporulation protein
HICBILPI_01138 9.2e-47 rplU J This protein binds to 23S rRNA in the presence of protein L20
HICBILPI_01139 3.2e-56 ysxB J ribosomal protein
HICBILPI_01140 5.5e-46 rpmA J Belongs to the bacterial ribosomal protein bL27 family
HICBILPI_01141 1.3e-105 spo0B T Sporulation initiation phospho-transferase B, C-terminal
HICBILPI_01142 3.8e-235 obg S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HICBILPI_01143 4.8e-73 pheB 5.4.99.5 S Belongs to the UPF0735 family
HICBILPI_01144 1.2e-160 pheA 4.2.1.51 E Prephenate dehydratase
HICBILPI_01145 1.3e-93 niaR S small molecule binding protein (contains 3H domain)
HICBILPI_01146 1.5e-222 nifS 2.8.1.7 E Cysteine desulfurase
HICBILPI_01147 9.7e-294 nadB 1.3.5.4, 1.4.3.16 H Catalyzes the oxidation of L-aspartate to iminoaspartate
HICBILPI_01148 2.2e-151 nadC 1.4.3.16, 2.4.2.19 H Belongs to the NadC ModD family
HICBILPI_01149 7.7e-213 nadA 2.5.1.72 H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HICBILPI_01150 1.2e-126 safA M spore coat assembly protein SafA
HICBILPI_01151 3.2e-48 S Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
HICBILPI_01153 3.7e-93 bofC S BofC C-terminal domain
HICBILPI_01154 5.9e-106 ruvA 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
HICBILPI_01155 6.2e-185 ruvB 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
HICBILPI_01156 1.6e-20 yrzS S Protein of unknown function (DUF2905)
HICBILPI_01157 1.6e-191 queA 2.4.99.17 J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HICBILPI_01158 4e-228 tgt 2.4.2.29 F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
HICBILPI_01159 2.5e-37 yajC U Preprotein translocase subunit YajC
HICBILPI_01160 2.4e-60 yrzE S Protein of unknown function (DUF3792)
HICBILPI_01161 9.5e-110 yrbG S membrane
HICBILPI_01162 1.8e-271 spoVB S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
HICBILPI_01163 8.5e-50 yrzD S Post-transcriptional regulator
HICBILPI_01164 0.0 secF U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HICBILPI_01165 7.3e-86 yrvC P regulatory, ligand-binding protein related to C-terminal domains of K channels
HICBILPI_01166 2.6e-47 yrvD S Lipopolysaccharide assembly protein A domain
HICBILPI_01167 0.0 recJ L Single-stranded-DNA-specific exonuclease RecJ
HICBILPI_01168 7.7e-91 apt 2.4.2.22, 2.4.2.7 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HICBILPI_01169 0.0 relA 2.7.6.5 KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HICBILPI_01170 1.8e-75 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
HICBILPI_01171 2.5e-273 lytH 3.5.1.28 M COG3103 SH3 domain protein
HICBILPI_01174 3.7e-243 hisS 6.1.1.21 J histidyl-tRNA synthetase
HICBILPI_01175 0.0 aspS 6.1.1.12 J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HICBILPI_01176 2.8e-137 yrvM H COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1
HICBILPI_01177 1.6e-64 rarA L COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase
HICBILPI_01178 5.5e-161 rarA L COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase
HICBILPI_01179 7.8e-64 cymR K Transcriptional regulator
HICBILPI_01180 2.6e-211 iscS 2.8.1.7 E Cysteine desulfurase
HICBILPI_01181 2e-221 mnmA 2.8.1.13 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
HICBILPI_01182 1.7e-18 S COG0457 FOG TPR repeat
HICBILPI_01183 0.0 recD2 3.1.11.5 L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
HICBILPI_01184 3.4e-82 yrrD S protein conserved in bacteria
HICBILPI_01185 2.9e-30 yrzR
HICBILPI_01186 2.1e-08 S Protein of unknown function (DUF3918)
HICBILPI_01187 2.9e-106 glnP P ABC transporter
HICBILPI_01188 6.1e-109 gluC P ABC transporter
HICBILPI_01189 9.9e-127 glnH ET Belongs to the bacterial solute-binding protein 3 family
HICBILPI_01190 1.8e-41 glnQ 3.6.3.21 E COG1126 ABC-type polar amino acid transport system, ATPase component
HICBILPI_01191 2e-77 glnQ 3.6.3.21 E COG1126 ABC-type polar amino acid transport system, ATPase component
HICBILPI_01192 2e-162 yrrI S AI-2E family transporter
HICBILPI_01193 0.0 alaS 6.1.1.7 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HICBILPI_01194 8.5e-41 yrzL S Belongs to the UPF0297 family
HICBILPI_01195 1.2e-70 yqgF L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HICBILPI_01196 7.1e-46 yrzB S Belongs to the UPF0473 family
HICBILPI_01197 1.2e-189 mltG S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HICBILPI_01198 4.7e-117 yrrM 2.1.1.104 S O-methyltransferase
HICBILPI_01199 2.9e-173 yegQ O Peptidase U32
HICBILPI_01200 3.9e-245 yegQ O COG0826 Collagenase and related proteases
HICBILPI_01201 1.1e-113 udk 2.7.1.48 F Cytidine monophosphokinase
HICBILPI_01202 3.1e-78 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
HICBILPI_01203 0.0 pbpI 3.4.16.4 M Penicillin-binding Protein
HICBILPI_01204 8.1e-70 yrrS S Protein of unknown function (DUF1510)
HICBILPI_01205 4.1e-27 yrzA S Protein of unknown function (DUF2536)
HICBILPI_01206 1e-116 yrrT 4.4.1.21 Q Could be a S-adenosyl-L-methionine-dependent methyltransferase
HICBILPI_01207 7.2e-124 mtnN 3.2.2.9 E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HICBILPI_01208 8e-171 mccA 2.5.1.134, 2.5.1.47 E Cysteine synthase
HICBILPI_01209 1.4e-209 mccB 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
HICBILPI_01210 5.1e-34 yrhC S YrhC-like protein
HICBILPI_01211 7e-81 yrhD S Protein of unknown function (DUF1641)
HICBILPI_01212 0.0 fdhA 1.17.1.10, 1.17.1.9 C formate dehydrogenase, alpha subunit
HICBILPI_01213 1.9e-59 yrhF S Uncharacterized conserved protein (DUF2294)
HICBILPI_01214 8e-143 focA P Formate nitrite
HICBILPI_01216 1.3e-77 yrhH Q methyltransferase
HICBILPI_01217 1.2e-100 Z012_03230 K Tetracycline repressor, C-terminal all-alpha domain
HICBILPI_01218 0.0 MA20_16700 1.14.14.1, 1.6.2.4 C Belongs to the cytochrome P450 family
HICBILPI_01219 1.9e-212 ynfM EGP Major facilitator Superfamily
HICBILPI_01220 5.9e-163 yybE K Transcriptional regulator
HICBILPI_01221 2.6e-80 ybaK S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HICBILPI_01222 8.7e-181 romA S Beta-lactamase superfamily domain
HICBILPI_01223 0.0 manR 2.7.1.200, 2.7.1.202 GKT transcriptional antiterminator
HICBILPI_01224 0.0 manP 2.7.1.191, 2.7.1.202 G phosphotransferase system
HICBILPI_01225 3.8e-184 manA 5.3.1.8 G mannose-6-phosphate isomerase
HICBILPI_01226 5.9e-129 glvR K Helix-turn-helix domain, rpiR family
HICBILPI_01227 3.9e-145 ybjI 3.1.3.102, 3.1.3.104, 3.1.3.23 S Sucrose-6F-phosphate phosphohydrolase
HICBILPI_01228 4.2e-144 S hydrolase
HICBILPI_01230 8.9e-92 yrdA S DinB family
HICBILPI_01231 6.7e-82 yyaR K Acetyltransferase (GNAT) domain
HICBILPI_01232 1.5e-218 tetL EGP Major facilitator Superfamily
HICBILPI_01234 1.5e-09 yyaR K acetyltransferase
HICBILPI_01235 9.2e-95 adk 2.7.4.3 F adenylate kinase activity
HICBILPI_01236 3.4e-147 ydeE K AraC family transcriptional regulator
HICBILPI_01237 2.1e-91 K Transcriptional regulator PadR-like family
HICBILPI_01238 1.1e-158 axeA S Carbohydrate esterase, sialic acid-specific acetylesterase
HICBILPI_01239 1.5e-124 sigK K sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HICBILPI_01240 8.8e-213 EGP Major facilitator Superfamily
HICBILPI_01241 8e-106 yqeD S SNARE associated Golgi protein
HICBILPI_01242 3.8e-139 3.5.1.104 G Polysaccharide deacetylase
HICBILPI_01243 2.5e-138 yqeF E GDSL-like Lipase/Acylhydrolase
HICBILPI_01245 7.6e-94 yqeG S hydrolase of the HAD superfamily
HICBILPI_01246 1.3e-212 yqeH S In Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis
HICBILPI_01247 1.2e-157 aroE 1.1.1.25 E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HICBILPI_01248 4.8e-45 yhbY J RNA-binding protein containing KH domain, possibly ribosomal protein
HICBILPI_01249 2.5e-106 nadD 2.7.7.18, 3.6.1.55 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HICBILPI_01250 2.9e-102 nadD 2.7.6.3, 2.7.7.18 H HD superfamily hydrolase involved in NAD metabolism
HICBILPI_01251 7.6e-61 rsfS J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
HICBILPI_01252 1.1e-138 yqeM Q Methyltransferase
HICBILPI_01253 3.8e-148 comER E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HICBILPI_01254 9.6e-104 comEA L COG1555 DNA uptake protein and related DNA-binding proteins
HICBILPI_01255 8e-105 comEB 3.5.4.12 F ComE operon protein 2
HICBILPI_01256 0.0 comEC S Competence protein ComEC
HICBILPI_01257 7.2e-181 holA 2.7.7.7 L DNA polymerase III delta subunit
HICBILPI_01258 2.2e-36 rpsT J Binds directly to 16S ribosomal RNA
HICBILPI_01259 2.3e-204 gpr 3.4.24.78 C Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HICBILPI_01260 7.8e-219 spoIIP M stage II sporulation protein P
HICBILPI_01261 2.5e-53 yqxA S Protein of unknown function (DUF3679)
HICBILPI_01262 0.0 lepA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
HICBILPI_01263 8.5e-215 hemN H Involved in the biosynthesis of porphyrin-containing compound
HICBILPI_01264 2.3e-187 hrcA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
HICBILPI_01265 3.5e-76 grpE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HICBILPI_01266 0.0 dnaK O Heat shock 70 kDa protein
HICBILPI_01267 1.1e-198 dnaJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
HICBILPI_01268 6.6e-173 prmA J Methylates ribosomal protein L11
HICBILPI_01269 3.9e-139 rsmE 2.1.1.193 J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
HICBILPI_01270 2.1e-260 yqeV 2.8.4.5 J ribosomal protein S12 methylthiotransferase
HICBILPI_01271 3.4e-71 yqeW P COG1283 Na phosphate symporter
HICBILPI_01272 6.5e-74 yqeW P COG1283 Na phosphate symporter
HICBILPI_01273 1.2e-19 rpsU J Belongs to the bacterial ribosomal protein bS21 family
HICBILPI_01274 8e-68 yqeY S Yqey-like protein
HICBILPI_01275 5.7e-231 yqeZ O COG1030 Membrane-bound serine protease (ClpP class)
HICBILPI_01276 3.8e-118 yqfA S UPF0365 protein
HICBILPI_01277 9.9e-47 yqfB
HICBILPI_01278 9.3e-46 yqfC S sporulation protein YqfC
HICBILPI_01279 5.7e-214 yqfD 3.1.3.102, 3.1.3.104 S Stage IV sporulation
HICBILPI_01280 6.6e-176 phoH T Phosphate starvation-inducible protein PhoH
HICBILPI_01281 0.0 yqfF S membrane-associated HD superfamily hydrolase
HICBILPI_01282 4.3e-80 ybeY 2.6.99.2, 3.5.4.5 S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HICBILPI_01283 1.3e-63 dgkA 2.7.1.107, 2.7.1.66 M Diacylglycerol kinase
HICBILPI_01284 7e-30 cdd 2.4.2.2, 3.5.4.5 F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
HICBILPI_01285 2e-166 era S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HICBILPI_01286 1.8e-16 S YqzL-like protein
HICBILPI_01287 3.4e-143 recO L Involved in DNA repair and RecF pathway recombination
HICBILPI_01288 5.1e-175 glyQ 6.1.1.14 J glycyl-tRNA synthetase alpha subunit
HICBILPI_01289 0.0 glyS 6.1.1.14 J Glycyl-tRNA synthetase beta subunit
HICBILPI_01290 4.5e-112 ccpN K CBS domain
HICBILPI_01291 2e-149 yqfL 2.7.11.33, 2.7.4.28 S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation
HICBILPI_01292 6.1e-88 yaiI S Belongs to the UPF0178 family
HICBILPI_01293 0.0 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
HICBILPI_01294 2.4e-201 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
HICBILPI_01295 1.1e-62 cccA C COG2010 Cytochrome c, mono- and diheme variants
HICBILPI_01296 1.4e-125 trmK 2.1.1.217 S SAM-dependent methyltransferase
HICBILPI_01297 2.1e-210 yqfO 3.5.4.16 S Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HICBILPI_01298 6.5e-176 ispH 1.17.7.4, 2.7.4.25 IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HICBILPI_01299 3.7e-43 yqfQ S YqfQ-like protein
HICBILPI_01300 6.8e-240 cshB 3.6.4.13 JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
HICBILPI_01301 1.4e-86 nfo 3.1.21.2 L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HICBILPI_01302 2e-39 nfo 3.1.21.2 L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HICBILPI_01303 9.3e-37 yqfT S Protein of unknown function (DUF2624)
HICBILPI_01304 5.3e-156 yqfU S Uncharacterized protein conserved in bacteria (DUF2179)
HICBILPI_01305 2.9e-72 zur P Belongs to the Fur family
HICBILPI_01306 3.2e-109 yqfW S Belongs to the 5'(3')-deoxyribonucleotidase family
HICBILPI_01307 3.2e-18 yqfX S membrane
HICBILPI_01308 2.4e-20 yqfX S membrane
HICBILPI_01309 3.1e-201 ispG 1.17.7.1, 1.17.7.3 I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HICBILPI_01310 3.1e-47 yqfZ M LysM domain
HICBILPI_01311 2.4e-128 yqgB S Protein of unknown function (DUF1189)
HICBILPI_01312 2.9e-71 yqgC S protein conserved in bacteria
HICBILPI_01313 6.9e-115 sodA 1.15.1.1 P radicals which are normally produced within the cells and which are toxic to biological systems
HICBILPI_01314 3.4e-228 yqgE EGP Major facilitator superfamily
HICBILPI_01315 0.0 pbpA 3.4.16.4 M penicillin-binding protein
HICBILPI_01316 7.6e-158 pstS P Phosphate
HICBILPI_01317 6.8e-154 pstC P probably responsible for the translocation of the substrate across the membrane
HICBILPI_01318 2.9e-154 pstA P Phosphate transport system permease
HICBILPI_01319 6.1e-143 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
HICBILPI_01320 7.5e-146 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
HICBILPI_01321 1.1e-75 yqzC S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HICBILPI_01322 1.2e-50 yqzD
HICBILPI_01323 9.4e-21 rpmG J Belongs to the bacterial ribosomal protein bL33 family
HICBILPI_01324 1e-96 ygfA 6.3.3.2 H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HICBILPI_01325 4e-07 yqgO
HICBILPI_01326 1e-230 nhaC C Na H antiporter
HICBILPI_01327 8.5e-28 yqgQ S Protein conserved in bacteria
HICBILPI_01328 2.2e-179 glcK 2.7.1.2 G Glucokinase
HICBILPI_01329 1.2e-216 yqgT 3.4.19.11 E Gamma-D-glutamyl-L-diamino acid endopeptidase
HICBILPI_01330 1.1e-197 yqgU
HICBILPI_01331 4.5e-49 yqgV S Thiamine-binding protein
HICBILPI_01332 5.4e-20 yqgW S Protein of unknown function (DUF2759)
HICBILPI_01333 7.3e-123 ycbL 3.1.2.6 S COG0491 Zn-dependent hydrolases, including glyoxylases
HICBILPI_01334 3.1e-37 yqgY S Protein of unknown function (DUF2626)
HICBILPI_01335 9.2e-65 yqgZ 1.20.4.1 P Belongs to the ArsC family
HICBILPI_01337 6.5e-148 yqhA T COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
HICBILPI_01338 9.3e-215 corC1 S COG1253 Hemolysins and related proteins containing CBS domains
HICBILPI_01339 1.2e-185 corA P Mg2 transporter protein
HICBILPI_01340 1.7e-201 comGA NU COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HICBILPI_01341 3.2e-184 comGB NU COG1459 Type II secretory pathway, component PulF
HICBILPI_01342 8.9e-50 comGC U Required for transformation and DNA binding
HICBILPI_01343 2.9e-70 gspH NU Tfp pilus assembly protein FimT
HICBILPI_01344 1.3e-19 comGE
HICBILPI_01345 1.6e-64 comGF U Putative Competence protein ComGF
HICBILPI_01346 1e-60 S ComG operon protein 7
HICBILPI_01347 2.3e-26 yqzE S YqzE-like protein
HICBILPI_01348 1.1e-53 yqzG S Protein of unknown function (DUF3889)
HICBILPI_01349 1.2e-120 yqxM
HICBILPI_01350 1.9e-69 sipW 3.4.21.89 U Signal peptidase
HICBILPI_01351 1.6e-140 tasA S Cell division protein FtsN
HICBILPI_01352 7.8e-55 sinR K transcriptional
HICBILPI_01353 5.2e-23 sinI S Anti-repressor SinI
HICBILPI_01354 2.5e-152 yqhG S Bacterial protein YqhG of unknown function
HICBILPI_01355 0.0 yqhH L COG0553 Superfamily II DNA RNA helicases, SNF2 family
HICBILPI_01356 1.5e-208 gcvT 1.4.4.2, 2.1.2.10 E The glycine cleavage system catalyzes the degradation of glycine
HICBILPI_01357 2.3e-251 gcvPA 1.4.4.2 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HICBILPI_01358 1.6e-285 gcvPB 1.4.4.2 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HICBILPI_01359 2.7e-64 yqhL P COG0607 Rhodanese-related sulfurtransferase
HICBILPI_01360 7.5e-160 lipM 6.3.1.20 H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation
HICBILPI_01361 6.2e-12 mntR K Involved in manganese homeostasis. Might activate the transcription of the mntABCD operon
HICBILPI_01362 6.7e-50 mntR K Involved in manganese homeostasis. Might activate the transcription of the mntABCD operon
HICBILPI_01363 3.1e-164 yqhO S esterase of the alpha-beta hydrolase superfamily
HICBILPI_01364 5.8e-62 yqhP
HICBILPI_01365 1.2e-172 yqhQ S Protein of unknown function (DUF1385)
HICBILPI_01366 3.7e-88 yqhR S Conserved membrane protein YqhR
HICBILPI_01367 3.3e-176 yqhT 3.4.11.9, 3.4.13.9 E COG0006 Xaa-Pro aminopeptidase
HICBILPI_01368 5.4e-98 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HICBILPI_01369 1.8e-36 yqhV S Protein of unknown function (DUF2619)
HICBILPI_01370 1.6e-171 spoIIIAA S stage III sporulation protein AA
HICBILPI_01371 1.6e-83 spoIIIAB S Stage III sporulation protein
HICBILPI_01372 7.6e-29 spoIIIAC S stage III sporulation protein AC
HICBILPI_01373 2.5e-41 spoIIIAD S Stage III sporulation protein AD
HICBILPI_01374 6.3e-200 spoIIIAE S stage III sporulation protein AE
HICBILPI_01375 2.6e-101 spoIIIAF S Stage III sporulation protein AF (Spore_III_AF)
HICBILPI_01376 1.1e-116 spoIIIAG S stage III sporulation protein AG
HICBILPI_01377 2.5e-62 spoIIIAH S SpoIIIAH-like protein
HICBILPI_01378 4.6e-61 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
HICBILPI_01379 1.2e-255 accC 6.3.4.14, 6.4.1.2 I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
HICBILPI_01380 8.1e-67 yqhY S protein conserved in bacteria
HICBILPI_01381 9.5e-65 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HICBILPI_01382 1.1e-155 folD 1.5.1.5, 3.5.4.9 F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HICBILPI_01383 8e-143 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HICBILPI_01384 4.2e-87 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HICBILPI_01385 2e-39 xseB 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HICBILPI_01386 8.8e-159 ispA 2.5.1.1, 2.5.1.10, 2.5.1.29, 2.5.1.90 H Belongs to the FPP GGPP synthase family
HICBILPI_01387 0.0 dxs 2.2.1.7 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HICBILPI_01388 1.6e-91 rrmJ 2.1.1.226, 2.1.1.227 J rRNA methylase
HICBILPI_01389 3.9e-78 argR K Regulates arginine biosynthesis genes
HICBILPI_01390 7.3e-126 recN L May be involved in recombinational repair of damaged DNA
HICBILPI_01391 1e-154 recN L May be involved in recombinational repair of damaged DNA
HICBILPI_01392 9.5e-239 rseP 3.4.21.116 M Stage IV sporulation protein B
HICBILPI_01393 3.2e-144 KT May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process
HICBILPI_01394 2.6e-214 alr 5.1.1.1 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HICBILPI_01397 4.1e-214 yqiG C COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family
HICBILPI_01399 1.2e-112 K Protein of unknown function (DUF1232)
HICBILPI_01400 7.7e-101 ytaF P Probably functions as a manganese efflux pump
HICBILPI_01401 4.2e-17
HICBILPI_01402 8.8e-105 amiC 3.5.1.28 M Cell wall hydrolase autolysin
HICBILPI_01403 8.1e-134 yqiK 3.1.4.46 C glycerophosphoryl diester phosphodiesterase
HICBILPI_01404 2.4e-212 mmgA 2.3.1.9 I Belongs to the thiolase family
HICBILPI_01405 2.5e-155 hbdA 1.1.1.157 I Dehydrogenase
HICBILPI_01406 1.3e-202 mmgC I acyl-CoA dehydrogenase
HICBILPI_01407 9.4e-203 prpC 2.3.3.1, 2.3.3.5 C Belongs to the citrate synthase family
HICBILPI_01408 8.3e-276 prpD 4.2.1.79 S 2-methylcitrate dehydratase
HICBILPI_01409 1.8e-159 prpB 4.1.3.30 G Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HICBILPI_01410 3.2e-34 yqzF S Protein of unknown function (DUF2627)
HICBILPI_01411 0.0 bkdR 2.7.13.3 KT Transcriptional regulator
HICBILPI_01412 2.3e-151 pta 2.3.1.19, 2.3.1.8 C phosphate butyryltransferase
HICBILPI_01413 2.4e-206 ldh 1.4.1.9 E Belongs to the Glu Leu Phe Val dehydrogenases family
HICBILPI_01414 1.6e-205 buk 2.7.2.7 C Belongs to the acetokinase family
HICBILPI_01415 2.9e-265 lpdA 1.8.1.4 C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
HICBILPI_01416 2.1e-161 bfmBAA 1.2.4.4 C COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
HICBILPI_01417 4.6e-185 bfmBAB 1.2.4.1, 1.2.4.4 C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
HICBILPI_01419 3.2e-188 bfmBB 2.3.1.168, 2.3.1.61 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
HICBILPI_01420 1.7e-170 yegS 2.7.1.107 I COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
HICBILPI_01421 1e-75 yqiW S Belongs to the UPF0403 family
HICBILPI_01422 3.4e-135 artP ET Belongs to the bacterial solute-binding protein 3 family
HICBILPI_01423 3.8e-106 artQ E COG0765 ABC-type amino acid transport system, permease component
HICBILPI_01424 3.8e-128 artM 3.6.3.21 E COG1126 ABC-type polar amino acid transport system, ATPase component
HICBILPI_01425 1.4e-170 yqjA S Putative aromatic acid exporter C-terminal domain
HICBILPI_01426 3.1e-95 yqjB S protein conserved in bacteria
HICBILPI_01428 9.4e-74 mce 4.4.1.5, 5.1.99.1, 5.4.99.2 E COG0346 Lactoylglutathione lyase and related lyases
HICBILPI_01429 1.1e-286 mmdA 2.1.3.15, 6.4.1.3 I COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
HICBILPI_01430 4.7e-202 yqjE 3.4.11.4 E COG2195 Di- and tripeptidases
HICBILPI_01431 3.5e-98 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HICBILPI_01432 2.4e-25 yqzJ
HICBILPI_01433 7.3e-236 dinB 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HICBILPI_01434 7.7e-266 gnd 1.1.1.343, 1.1.1.44 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HICBILPI_01435 6.1e-290 zwf 1.1.1.363, 1.1.1.49 G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HICBILPI_01436 6.1e-171 rnz 3.1.26.11 S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
HICBILPI_01437 1.8e-144 yqjL S hydrolases or acyltransferases (alpha beta hydrolase superfamily)
HICBILPI_01438 4.8e-193 namA 1.6.99.1 C Catalyzes the reduction of the double bond of an array of alpha,beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes
HICBILPI_01439 1.6e-49 S GlpM protein
HICBILPI_01440 3e-159 K LysR substrate binding domain
HICBILPI_01441 7.7e-94 nusG K Participates in transcription elongation, termination and antitermination
HICBILPI_01442 0.0 fabD 1.13.12.16, 2.3.1.39 I malonyl CoA-acyl carrier protein transacylase
HICBILPI_01445 1.7e-246 IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
HICBILPI_01446 1.1e-127 IQ reductase
HICBILPI_01447 0.0 pksJ Q Polyketide synthase of type I
HICBILPI_01448 0.0 1.1.1.320 Q Polyketide synthase of type I
HICBILPI_01449 0.0 Q Polyketide synthase of type I
HICBILPI_01450 5.5e-121 Q Polyketide synthase of type I
HICBILPI_01451 0.0 pksJ Q Polyketide synthase of type I
HICBILPI_01452 0.0 pksJ Q Polyketide synthase of type I
HICBILPI_01453 0.0 pfaA Q Polyketide synthase of type I
HICBILPI_01454 0.0 Q Polyketide synthase of type I
HICBILPI_01455 0.0 Q Polyketide synthase of type I
HICBILPI_01456 0.0 Q Polyketide synthase of type I
HICBILPI_01457 0.0 pks13 1.6.5.5 C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases
HICBILPI_01458 3.1e-220 eryK 1.14.13.154 C Cytochrome P450
HICBILPI_01459 6.3e-238 pksG 2.3.3.10 I synthase
HICBILPI_01460 3.3e-135 pksI I Belongs to the enoyl-CoA hydratase isomerase family
HICBILPI_01461 2.4e-145 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HICBILPI_01462 3.7e-171 yqjP S COG0491 Zn-dependent hydrolases, including glyoxylases
HICBILPI_01463 5.5e-141 yqjQ S Belongs to the short-chain dehydrogenases reductases (SDR) family
HICBILPI_01464 8.2e-249 dsdA 4.3.1.18 E Belongs to the serine threonine dehydratase family. DsdA subfamily
HICBILPI_01465 5.9e-177 coaA 2.7.1.33 F Pantothenic acid kinase
HICBILPI_01466 1.2e-72 yqjT 3.1.26.4 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HICBILPI_01468 2.1e-71 yueF S transporter activity
HICBILPI_01470 2.1e-55 S YolD-like protein
HICBILPI_01471 1.8e-234 polYB 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HICBILPI_01472 8.7e-89 yqjY K acetyltransferase
HICBILPI_01473 9.6e-61 yqjZ 2.3.1.128, 2.5.1.18 S enzyme involved in biosynthesis of extracellular polysaccharides
HICBILPI_01474 7.6e-172 yqkA K GrpB protein
HICBILPI_01475 7.7e-61 yqkB S Belongs to the HesB IscA family
HICBILPI_01476 3.2e-39 yqkC S Protein of unknown function (DUF2552)
HICBILPI_01477 3.8e-29 yqkD S COG1073 Hydrolases of the alpha beta superfamily
HICBILPI_01478 2.5e-135 yqkD S COG1073 Hydrolases of the alpha beta superfamily
HICBILPI_01480 6.3e-168 yqkF C oxidoreductases (related to aryl-alcohol dehydrogenases)
HICBILPI_01482 1.6e-94 nudF 3.6.1.13 L Belongs to the Nudix hydrolase family
HICBILPI_01483 1.8e-213 yqxK 3.6.4.12 L DNA helicase
HICBILPI_01484 1e-57 ansR K Transcriptional regulator
HICBILPI_01485 2.9e-187 ansA 3.5.1.1 EJ L-asparaginase
HICBILPI_01486 1.3e-268 aspA 4.2.1.2, 4.3.1.1 E Aspartate ammonia-lyase
HICBILPI_01487 1.6e-239 mleN C Na H antiporter
HICBILPI_01488 3.8e-243 mleA 1.1.1.38 C malic enzyme
HICBILPI_01489 5.7e-22
HICBILPI_01490 8.6e-34 yqkK
HICBILPI_01491 2.1e-109 spoIIM S Required for complete septum migration and engulfment of the forespore compartment during sporulation. Required for stabilizing and recruiting of SpoIIP to the septal membrane
HICBILPI_01492 1.9e-80 fur P Belongs to the Fur family
HICBILPI_01493 3.7e-37 S Protein of unknown function (DUF4227)
HICBILPI_01494 8.2e-165 xerD L recombinase XerD
HICBILPI_01495 8.8e-231 deoB 5.4.2.7 G Phosphotransfer between the C1 and C5 carbon atoms of pentose
HICBILPI_01496 9.3e-147 punA 2.4.2.1 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HICBILPI_01497 2.2e-213 dacF 3.4.16.4 M Belongs to the peptidase S11 family
HICBILPI_01498 6.6e-57 spoIIAA T Belongs to the anti-sigma-factor antagonist family
HICBILPI_01499 1.8e-75 spoIIAB 2.7.11.1 F Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition
HICBILPI_01500 6.9e-136 sigF K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HICBILPI_01501 1.8e-110 spoVAA S Stage V sporulation protein AA
HICBILPI_01502 5.1e-60 spoVAB S Stage V sporulation protein AB
HICBILPI_01503 6e-79 spoVAC S stage V sporulation protein AC
HICBILPI_01504 1.2e-188 spoVAD I Stage V sporulation protein AD
HICBILPI_01505 5e-57 spoVAEB S stage V sporulation protein
HICBILPI_01506 7.1e-38 spoVAEA S stage V sporulation protein
HICBILPI_01507 2.4e-56 spoVAEA S stage V sporulation protein
HICBILPI_01508 3.2e-270 spoVAF EG Stage V sporulation protein AF
HICBILPI_01509 3.3e-83 lysA 4.1.1.19, 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
HICBILPI_01510 7e-164 lysA 4.1.1.19, 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
HICBILPI_01511 1.9e-153 ypuA S Secreted protein
HICBILPI_01512 4.4e-79 ppiB 5.2.1.8 O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HICBILPI_01513 1.2e-80 ccdC1 O Protein of unknown function (DUF1453)
HICBILPI_01514 5.8e-100 sipT 3.4.21.89 U Belongs to the peptidase S26 family
HICBILPI_01515 1.4e-48 ypuD
HICBILPI_01516 1.8e-209 ribD 1.1.1.193, 3.5.4.26 H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HICBILPI_01517 6.5e-111 ribE 2.5.1.9 H Riboflavin synthase
HICBILPI_01518 3.7e-229 ribBA 3.5.4.25, 4.1.99.12 H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HICBILPI_01519 2.5e-80 ribH 2.5.1.78 H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
HICBILPI_01520 3.5e-64 ribT K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HICBILPI_01521 2.9e-93 ypuF S Domain of unknown function (DUF309)
HICBILPI_01523 8.9e-128 scpA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HICBILPI_01524 1.7e-102 scpB D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HICBILPI_01525 3.8e-93 ypuI S Protein of unknown function (DUF3907)
HICBILPI_01526 6.6e-215 dacB 3.4.16.4 M Belongs to the peptidase S11 family
HICBILPI_01527 2e-103 spmA S Spore maturation protein
HICBILPI_01528 6.4e-88 spmB S Spore maturation protein
HICBILPI_01529 1.3e-131 rluB 5.4.99.19, 5.4.99.21, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
HICBILPI_01530 4.3e-100 resA CO Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c
HICBILPI_01531 0.0 ccs1 O COG1333 ResB protein required for cytochrome c biosynthesis
HICBILPI_01532 9.4e-193 ccsA O 'COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component'
HICBILPI_01533 8.8e-133 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HICBILPI_01534 0.0 resE 2.7.13.3 T Histidine kinase
HICBILPI_01535 9.1e-104 sigX K Belongs to the sigma-70 factor family. ECF subfamily
HICBILPI_01536 9.7e-192 rsiX
HICBILPI_01537 9.7e-294 serA 1.1.1.399, 1.1.1.95 E Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HICBILPI_01538 1.9e-93 fmnP U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HICBILPI_01539 3.6e-41 fer C Ferredoxin
HICBILPI_01540 1.1e-192 ypbB 5.1.3.1 S protein conserved in bacteria
HICBILPI_01541 1.5e-269 recQ 3.6.4.12 L DNA helicase
HICBILPI_01542 4e-99 ypbD S metal-dependent membrane protease
HICBILPI_01543 5.4e-72 ypbE M Lysin motif
HICBILPI_01544 5.7e-85 ypbF S Protein of unknown function (DUF2663)
HICBILPI_01545 7.6e-146 ypbG S Calcineurin-like phosphoesterase superfamily domain
HICBILPI_01546 2e-106 mecB NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC
HICBILPI_01547 1.4e-245 gudB 1.4.1.2, 1.4.1.3 E Belongs to the Glu Leu Phe Val dehydrogenases family
HICBILPI_01548 3.4e-188 ypdA 1.18.1.2, 1.19.1.1, 1.8.1.9 O COG0492 Thioredoxin reductase
HICBILPI_01549 4.1e-121 prsW S Involved in the degradation of specific anti-sigma factors
HICBILPI_01550 3e-159 sleB 3.5.1.28 M Spore cortex-lytic enzyme
HICBILPI_01551 4.6e-252 hemX 2.1.1.107, 4.2.1.75 H sporulation protein
HICBILPI_01552 1.2e-24 ypfA M Flagellar protein YcgR
HICBILPI_01553 5.4e-25 ypfA M Flagellar protein YcgR
HICBILPI_01554 1.4e-12 S Family of unknown function (DUF5359)
HICBILPI_01555 1e-111 cmk 1.17.7.4, 2.5.1.19, 2.7.1.26, 2.7.4.25, 2.7.7.2, 6.3.2.1 F Belongs to the cytidylate kinase family. Type 1 subfamily
HICBILPI_01556 1.5e-206 rpsA 1.17.7.4 J Ribosomal protein S1
HICBILPI_01557 5e-185 fni 1.1.1.88, 5.3.3.2 C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
HICBILPI_01558 4.7e-08 S YpzI-like protein
HICBILPI_01559 7.2e-104 yphA
HICBILPI_01560 1.6e-249 der 1.1.1.399, 1.1.1.95 S GTPase that plays an essential role in the late steps of ribosome biogenesis
HICBILPI_01561 5.1e-190 gpsA 1.1.1.94 I Glycerol-3-phosphate dehydrogenase
HICBILPI_01562 9.5e-16 yphE S Protein of unknown function (DUF2768)
HICBILPI_01563 1.1e-133 yphF
HICBILPI_01564 6.4e-279 spoIVA S ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HICBILPI_01565 4.7e-42 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
HICBILPI_01566 2.1e-100 folE 3.5.4.16 H GTP cyclohydrolase
HICBILPI_01567 1.3e-34 mtrB K Required for transcription attenuation control in the Trp operon. This trans-acting factor seems to recognize a 10 bases nucleotide sequence in the Trp leader transcript causing transcription termination. Binds the leader RNA only in presence of L-tryptophan
HICBILPI_01568 1.8e-136 hepS 2.5.1.30 H Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1
HICBILPI_01569 1.2e-131 menG 2.1.1.163, 2.1.1.201 H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)
HICBILPI_01570 7.4e-197 hepT 2.5.1.30, 2.5.1.83, 2.5.1.90 H Belongs to the FPP GGPP synthase family
HICBILPI_01571 5e-78 ndk 2.7.4.6 F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
HICBILPI_01572 1.1e-138 cheR 2.1.1.80 NT COG1352 Methylase of chemotaxis methyl-accepting proteins
HICBILPI_01573 9.4e-217 aroC 4.2.3.5 E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HICBILPI_01574 3.2e-203 aroB 2.7.1.71, 4.2.3.4 E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HICBILPI_01575 2.4e-60 aroH 2.7.4.25, 5.4.99.5 E Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis
HICBILPI_01576 2.7e-288 trpE 4.1.3.27 EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HICBILPI_01577 8.3e-153 trpD 2.4.2.18, 4.1.3.27 E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HICBILPI_01578 3.6e-129 trpC 4.1.1.48, 5.3.1.24 E Belongs to the TrpC family
HICBILPI_01579 1.7e-114 trpF 4.1.1.48, 4.2.1.160, 4.2.1.20, 5.3.1.24 E Belongs to the TrpF family
HICBILPI_01580 2.4e-228 trpB 4.2.1.20, 5.3.1.24 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HICBILPI_01581 8.5e-145 trpA 4.2.1.20 E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
HICBILPI_01582 1.9e-203 hisC 2.6.1.9 E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HICBILPI_01583 3.3e-203 tyrA 1.3.1.12, 1.3.1.43 E prephenate dehydrogenase
HICBILPI_01584 8.1e-238 aroA 1.3.1.12, 1.3.1.43, 2.5.1.19 E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
HICBILPI_01585 3.5e-233 S COG0457 FOG TPR repeat
HICBILPI_01586 2.1e-99 ypiB S Belongs to the UPF0302 family
HICBILPI_01587 3.2e-77 ypiF S Protein of unknown function (DUF2487)
HICBILPI_01588 9.3e-97 qcrA C Menaquinol-cytochrome c reductase
HICBILPI_01589 6.7e-127 petB C COG1290 Cytochrome b subunit of the bc complex
HICBILPI_01590 1.1e-146 qcrC C Menaquinol-cytochrome c reductase cytochrome b c subunit
HICBILPI_01591 2.9e-105 ypjA S membrane
HICBILPI_01592 9.5e-141 ypjB S sporulation protein
HICBILPI_01593 2.6e-227 oxdC 4.1.1.2 G Oxalate decarboxylase
HICBILPI_01594 3.6e-157 ypjC S Uncharacterized protein conserved in bacteria (DUF2179)
HICBILPI_01595 1.8e-56 ypjD 2.5.1.19 S Nucleotide pyrophosphohydrolase
HICBILPI_01596 9.1e-147 dapB 1.17.1.8 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
HICBILPI_01597 1.2e-70 mgsA 2.7.1.24, 4.2.3.3 G methylglyoxal synthase
HICBILPI_01598 1.9e-132 bshB1 S proteins, LmbE homologs
HICBILPI_01599 2.4e-209 bshA GT4 M N-acetyl-alpha-D-glucosaminyl L-malate synthase
HICBILPI_01600 7.8e-219 cca 2.7.7.19, 2.7.7.72 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HICBILPI_01601 6.2e-182 birA 6.3.4.15 K Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
HICBILPI_01602 1.7e-148 panB 2.1.2.11 H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
HICBILPI_01603 2.7e-157 panC 2.7.4.25, 6.3.2.1 H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HICBILPI_01604 1.3e-28 panD 4.1.1.11 H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HICBILPI_01605 5.5e-144 dinG 2.7.7.7, 3.6.4.12 L helicase involved in DNA repair and perhaps also replication
HICBILPI_01606 0.0 dinG 2.7.7.7, 3.6.4.12 L helicase involved in DNA repair and perhaps also replication
HICBILPI_01607 6.7e-23 ypmA S Protein of unknown function (DUF4264)
HICBILPI_01608 1.5e-80 ypmB S protein conserved in bacteria
HICBILPI_01609 1.1e-56 aspB 2.6.1.1, 2.6.1.14 E Aminotransferase
HICBILPI_01610 2.6e-152 aspB 2.6.1.1, 2.6.1.14 E Aminotransferase
HICBILPI_01611 9.9e-252 asnS 6.1.1.22 J asparaginyl-tRNA
HICBILPI_01612 3e-130 dnaD L DNA replication protein DnaD
HICBILPI_01613 2.4e-121 nth 4.2.99.18 L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HICBILPI_01614 5.7e-91 ypoC
HICBILPI_01615 2e-159 ponA 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
HICBILPI_01616 8.8e-244 ponA 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
HICBILPI_01617 1.8e-110 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
HICBILPI_01618 2.6e-188 yppC S Protein of unknown function (DUF2515)
HICBILPI_01621 3.3e-11 yppE S Bacterial domain of unknown function (DUF1798)
HICBILPI_01623 2.1e-49 yppG S YppG-like protein
HICBILPI_01624 7.9e-70 hspX O Belongs to the small heat shock protein (HSP20) family
HICBILPI_01625 1e-87 ypqE 2.7.1.199 G COG2190 Phosphotransferase system IIA components
HICBILPI_01626 0.0 yprA L COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster
HICBILPI_01627 8e-235 yprB L RNase_H superfamily
HICBILPI_01629 9.9e-33 cotD S Inner spore coat protein D
HICBILPI_01630 1.1e-98 ypsA S Belongs to the UPF0398 family
HICBILPI_01631 3.4e-46 gpsB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
HICBILPI_01632 5.1e-215 rlmL 2.1.1.173, 2.1.1.264 L Belongs to the methyltransferase superfamily
HICBILPI_01633 6.6e-22 S YpzG-like protein
HICBILPI_01635 0.0 ypvA 3.6.4.12 KL COG1199 Rad3-related DNA helicases
HICBILPI_01636 4.8e-290 ypwA 3.4.17.19 E Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HICBILPI_01637 6.3e-97 xpt 2.4.2.22, 2.4.2.7 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
HICBILPI_01638 2.9e-64 pbuX F xanthine
HICBILPI_01639 4e-50 L Recombinase
HICBILPI_01640 1.4e-77 yokF 3.1.31.1 L RNA catabolic process
HICBILPI_01641 1.5e-92 G SMI1-KNR4 cell-wall
HICBILPI_01642 2e-167 V HNH endonuclease
HICBILPI_01643 7.4e-218 yobL L A nuclease of the HNH/ENDO VII superfamily with conserved LHH
HICBILPI_01644 7.8e-97 yokK S SMI1 / KNR4 family
HICBILPI_01646 4.8e-129 yunB S Sporulation protein YunB (Spo_YunB)
HICBILPI_01647 5.3e-40 S YolD-like protein
HICBILPI_01648 3.2e-223 dinB2 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HICBILPI_01650 7.4e-89 S response regulator aspartate phosphatase
HICBILPI_01653 2.1e-22 S Bacteriophage holin
HICBILPI_01655 8.4e-76 xlyB 3.5.1.104, 3.5.1.28 M N-acetylmuramoyl-L-alanine amidase
HICBILPI_01656 2.1e-266 M Pectate lyase superfamily protein
HICBILPI_01657 9.1e-94
HICBILPI_01658 0.0 S Pfam Transposase IS66
HICBILPI_01659 1.9e-125 S Phage tail protein
HICBILPI_01660 0.0 XK26_06135 M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)
HICBILPI_01661 1.8e-268 S peptidoglycan catabolic process
HICBILPI_01662 3.8e-77
HICBILPI_01664 3e-67 S DNA integration
HICBILPI_01665 4.6e-49
HICBILPI_01666 1.1e-57
HICBILPI_01668 5.9e-74
HICBILPI_01669 3.9e-49
HICBILPI_01671 7.1e-91
HICBILPI_01672 2.6e-89
HICBILPI_01673 1.3e-85
HICBILPI_01674 1.8e-55
HICBILPI_01677 4e-68
HICBILPI_01679 6.3e-40
HICBILPI_01680 8.2e-19
HICBILPI_01681 1.8e-94
HICBILPI_01682 1.3e-14
HICBILPI_01685 1e-218 S Calcineurin-like phosphoesterase superfamily domain
HICBILPI_01689 1e-33 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
HICBILPI_01690 0.0
HICBILPI_01694 6.4e-58 ftsZ D Tubulin/FtsZ family, GTPase domain
HICBILPI_01696 1.2e-214
HICBILPI_01698 8.6e-197 3.1.21.3 L Domain of unknown function (DUF4942)
HICBILPI_01702 4.5e-17
HICBILPI_01703 4.4e-09
HICBILPI_01705 6.2e-21 I Acyltransferase family
HICBILPI_01706 5.4e-69 yoaW
HICBILPI_01707 8e-23 K Cro/C1-type HTH DNA-binding domain
HICBILPI_01717 5e-40 S HicB_like antitoxin of bacterial toxin-antitoxin system
HICBILPI_01718 2.2e-77
HICBILPI_01724 1.2e-37 L Belongs to the 'phage' integrase family
HICBILPI_01725 5.8e-186
HICBILPI_01726 4.9e-33
HICBILPI_01727 2.4e-12 K Transcriptional regulator
HICBILPI_01731 2.1e-42
HICBILPI_01732 5.6e-07 S YopX protein
HICBILPI_01735 5.8e-265 3.1.3.16, 3.1.4.37 T phosphatase
HICBILPI_01739 1.1e-84 S Protein of unknown function (DUF1273)
HICBILPI_01745 5.2e-74
HICBILPI_01747 1.2e-51 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F deoxyuridine 5'-triphosphate nucleotidohydrolase
HICBILPI_01750 6.4e-64
HICBILPI_01752 3.9e-137 ligB 6.5.1.1, 6.5.1.6, 6.5.1.7 L ATP-dependent DNA ligase
HICBILPI_01753 6.3e-125 yoqW S Belongs to the SOS response-associated peptidase family
HICBILPI_01756 8.2e-10 S YopX protein
HICBILPI_01757 8.8e-159
HICBILPI_01759 2.9e-33 S YopX protein
HICBILPI_01761 1.1e-89 S Pfam:DUF867
HICBILPI_01762 3e-219 M Parallel beta-helix repeats
HICBILPI_01766 1.4e-170
HICBILPI_01767 8.5e-159 S AAA domain
HICBILPI_01769 1.4e-241 3.6.4.12 L DnaB-like helicase C terminal domain
HICBILPI_01770 5.2e-147 3.6.4.12 L DNA primase activity
HICBILPI_01771 1.1e-171 S PD-(D/E)XK nuclease superfamily
HICBILPI_01772 5.8e-292 polB 2.7.7.7 L DNA polymerase elongation subunit (Family B)
HICBILPI_01773 1.2e-23 DR0488 S protein conserved in bacteria
HICBILPI_01776 1e-69 tmk 2.1.1.45, 2.7.4.9 F dTDP biosynthetic process
HICBILPI_01777 2.5e-89 yorS 3.1.3.5 S 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
HICBILPI_01804 1.1e-54 S NrdI Flavodoxin like
HICBILPI_01805 0.0 S ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
HICBILPI_01807 7.5e-175 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HICBILPI_01808 5.3e-26 O Glutaredoxin
HICBILPI_01809 9.1e-54 ymaB S MutT family
HICBILPI_01814 2.2e-151 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HICBILPI_01815 1.1e-28 folA 1.5.1.3 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HICBILPI_01819 5.7e-10
HICBILPI_01821 4.9e-23 sspB S spore protein
HICBILPI_01822 8.3e-151 S Calcineurin-like phosphoesterase
HICBILPI_01830 7.1e-90 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
HICBILPI_01832 4e-159 pbuX F xanthine
HICBILPI_01834 1.6e-97 yrdC 3.5.1.19 Q Isochorismatase family
HICBILPI_01835 6.3e-28 ydfR S Protein of unknown function (DUF421)
HICBILPI_01836 3.9e-22 ydfR S Protein of unknown function (DUF421)
HICBILPI_01838 1.5e-49 ybaZ 2.1.1.63 L 6-O-methylguanine DNA methyltransferase, DNA binding domain
HICBILPI_01839 1.6e-106 J Acetyltransferase (GNAT) domain
HICBILPI_01840 1.9e-203 bcsA Q Naringenin-chalcone synthase
HICBILPI_01841 2.7e-88 ypbQ S protein conserved in bacteria
HICBILPI_01842 0.0 ypbR S Dynamin family
HICBILPI_01843 2.2e-38 ypbS S Protein of unknown function (DUF2533)
HICBILPI_01845 5.9e-163 polA 2.7.7.7 L 5'3' exonuclease
HICBILPI_01847 7.1e-68 rnhA 3.1.26.4 L Ribonuclease
HICBILPI_01848 2e-118 ypdP S Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HICBILPI_01849 9.1e-124 ypeP 3.1.26.4 L COG0328 Ribonuclease HI
HICBILPI_01850 1.5e-28 ypeQ S Zinc-finger
HICBILPI_01851 6.1e-36 S Protein of unknown function (DUF2564)
HICBILPI_01852 1.3e-11 degR
HICBILPI_01853 1e-30 cspD K Cold-shock protein
HICBILPI_01854 1.1e-214 ugtP 2.4.1.315 GT28 M Processive glucosyltransferase involved in the biosynthesis of both the bilayer- and non-bilayer-forming membrane glucolipids. Is able to successively transfer up to three glucosyl residues to diacylglycerol (DAG), thereby catalyzing the formation of beta-monoglucosyl-DAG (3-O-(beta-D-glucopyranosyl)-1,2-diacyl- sn-glycerol), beta-diglucosyl-DAG (3-O-(beta-D-glucopyranosyl- beta-(1- 6)-D-glucopyranosyl)-1,2-diacyl-sn-glycerol) and beta- triglucosyl-DAG (3-O-(beta-D-glucopyranosyl-beta-(1- 6)-D- glucopyranosyl-beta-(1- 6)-D-glucopyranosyl)-1,2-diacyl-sn- glycerol). Beta-diglucosyl-DAG is the predominant glycolipid found in Bacillales and is also used as a membrane anchor for lipoteichoic acid (LTA)
HICBILPI_01855 3.3e-177 metAA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HICBILPI_01856 7.1e-86 btuE 1.11.1.9 O Belongs to the glutathione peroxidase family
HICBILPI_01857 3.1e-99 ypgQ S phosphohydrolase
HICBILPI_01858 4.4e-155 ypgR C COG0694 Thioredoxin-like proteins and domains
HICBILPI_01859 5.6e-80 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
HICBILPI_01860 6.1e-199 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
HICBILPI_01861 1e-75 yphP S Belongs to the UPF0403 family
HICBILPI_01862 1.1e-130 ypiP 2.1.1.242 AJ Putative SAM-dependent methyltransferase
HICBILPI_01863 8.5e-113 ypjP S YpjP-like protein
HICBILPI_01864 8.7e-158 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HICBILPI_01865 1.3e-90 folA 1.1.1.262, 1.5.1.3 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HICBILPI_01866 6.1e-114 ypkP 2.3.1.40, 2.3.1.51, 6.2.1.20 I Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family
HICBILPI_01867 3.5e-109 hlyIII S protein, Hemolysin III
HICBILPI_01868 1.6e-172 pspF K Transcriptional regulator
HICBILPI_01869 6.3e-243 ilvA 4.3.1.19 E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HICBILPI_01870 1.4e-37 ypmP S Protein of unknown function (DUF2535)
HICBILPI_01871 5.1e-107 ypmQ S protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems
HICBILPI_01872 6.4e-134 ypmR E GDSL-like Lipase/Acylhydrolase
HICBILPI_01873 6.1e-97 ypmS S protein conserved in bacteria
HICBILPI_01874 1.4e-66 ypoP K transcriptional
HICBILPI_01875 2.7e-102 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HICBILPI_01876 1.2e-81 msrB 1.8.4.11, 1.8.4.12 O peptide methionine sulfoxide reductase
HICBILPI_01877 2.6e-103 4.2.1.115 GM Polysaccharide biosynthesis protein
HICBILPI_01878 6e-283 yokA L Recombinase
HICBILPI_01880 1.7e-47 yokH G SMI1 / KNR4 family
HICBILPI_01881 2.4e-26 yokH G SMI1 / KNR4 family
HICBILPI_01882 4.1e-288 yobL L A nuclease of the HNH/ENDO VII superfamily with conserved LHH
HICBILPI_01883 7.5e-53 S SMI1-KNR4 cell-wall
HICBILPI_01884 4.9e-89 yokK S SMI1 / KNR4 family
HICBILPI_01885 6.6e-30 S Acetyltransferase (GNAT) domain
HICBILPI_01886 7e-24
HICBILPI_01887 2.6e-08 S Domain of unknown function (DUF4879)
HICBILPI_01889 7.2e-157 3.4.24.40 S amine dehydrogenase activity
HICBILPI_01892 1.9e-206 S aspartate phosphatase
HICBILPI_01893 5.3e-75 yoqH M LysM domain
HICBILPI_01897 2.6e-08
HICBILPI_01898 2.5e-22 ligB 6.5.1.1, 6.5.1.6, 6.5.1.7 L ATP-dependent DNA ligase
HICBILPI_01899 1.7e-77
HICBILPI_01905 7.9e-73 4.2.1.115 GM Polysaccharide biosynthesis protein
HICBILPI_01906 2.6e-219 phy 3.1.3.8 I Myo-inositol-hexaphosphate 3-phosphohydrolase
HICBILPI_01907 1.4e-178 cgeB S Spore maturation protein
HICBILPI_01908 1.6e-52 cgeA
HICBILPI_01909 1.1e-39 cgeC
HICBILPI_01910 1.1e-209 cgeD M maturation of the outermost layer of the spore
HICBILPI_01911 1.4e-144 yiiD K acetyltransferase
HICBILPI_01913 3.2e-64 yosT L Bacterial transcription activator, effector binding domain
HICBILPI_01914 1.9e-245 yodT H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HICBILPI_01915 2.9e-125 yodS 2.8.3.8, 2.8.3.9 I COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HICBILPI_01916 2.7e-123 scoB 2.8.3.5, 2.8.3.8, 2.8.3.9 I COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit
HICBILPI_01917 9e-253 yodQ 3.5.1.16 E Acetylornithine deacetylase
HICBILPI_01918 9.8e-155 yodP 2.3.1.264 K Acetyltransferase (GNAT) family
HICBILPI_01919 3.6e-279 kamA 5.4.3.2 E lysine 2,3-aminomutase
HICBILPI_01920 9.2e-46 yokU S YokU-like protein, putative antitoxin
HICBILPI_01921 9.1e-36 yozE S Belongs to the UPF0346 family
HICBILPI_01922 2.6e-24 E lactoylglutathione lyase activity
HICBILPI_01923 1.7e-125 yodN
HICBILPI_01925 6.2e-24 yozD S YozD-like protein
HICBILPI_01926 1.4e-102 yodM 3.6.1.27 I Acid phosphatase homologues
HICBILPI_01927 3.3e-55 yodL S YodL-like
HICBILPI_01929 3.5e-126 deoD 2.4.2.1, 2.4.2.28 F Purine nucleoside phosphorylase
HICBILPI_01930 2.3e-121 vanY 3.4.17.14 M D-alanyl-D-alanine carboxypeptidase
HICBILPI_01931 1.9e-21 yodI
HICBILPI_01932 2.8e-128 yodH Q Methyltransferase
HICBILPI_01933 7.9e-255 ctpA 3.4.21.102 M Belongs to the peptidase S41A family
HICBILPI_01934 2.6e-132 yydK K Transcriptional regulator
HICBILPI_01935 1.5e-288 bglA 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
HICBILPI_01936 1e-276 3.2.1.45 GH30 M Glycosyl hydrolase family 30 beta sandwich domain
HICBILPI_01937 3e-268 yodF E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HICBILPI_01938 1.4e-19 S Protein of unknown function (DUF3311)
HICBILPI_01939 5e-173 yodE E COG0346 Lactoylglutathione lyase and related lyases
HICBILPI_01940 5.7e-109 mhqD S Carboxylesterase
HICBILPI_01941 4.5e-106 yodC C nitroreductase
HICBILPI_01942 3e-56 yodB K transcriptional
HICBILPI_01943 3.9e-68 yoaQ S Evidence 4 Homologs of previously reported genes of
HICBILPI_01944 2.3e-66 yodA S tautomerase
HICBILPI_01946 2.5e-80 yozR S COG0071 Molecular chaperone (small heat shock protein)
HICBILPI_01947 4.9e-23
HICBILPI_01948 3.7e-60 yojF S Protein of unknown function (DUF1806)
HICBILPI_01949 5.6e-126 yojG S deacetylase
HICBILPI_01950 2.2e-151 T COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
HICBILPI_01951 6.1e-236 norM V Multidrug efflux pump
HICBILPI_01953 1.7e-111 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HICBILPI_01954 6.9e-223 yojK CG UDP-glucoronosyl and UDP-glucosyl transferase
HICBILPI_01955 5.2e-226 sle1 3.5.1.28 CBM50 M COG1388 FOG LysM repeat
HICBILPI_01956 8.9e-99 sodC 1.15.1.1 P Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HICBILPI_01957 1.6e-163 yojN S ATPase family associated with various cellular activities (AAA)
HICBILPI_01958 0.0 yojO P Von Willebrand factor
HICBILPI_01959 0.0 sucA 1.2.4.2, 4.1.1.71 C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)
HICBILPI_01960 5.5e-183 sucB 2.3.1.61 C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)
HICBILPI_01961 7.2e-138 S Metallo-beta-lactamase superfamily
HICBILPI_01962 3e-160 yocS S -transporter
HICBILPI_01963 1.6e-52 yocR S Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
HICBILPI_01964 1.8e-174 yocR S Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
HICBILPI_01965 1.2e-165 sodA 1.15.1.1 P Superoxide dismutase
HICBILPI_01966 0.0 sqhC 4.2.1.137, 5.4.99.7 I COG1657 Squalene cyclase
HICBILPI_01967 9.8e-288 dhaS 1.2.1.3, 1.2.1.39 C Belongs to the aldehyde dehydrogenase family
HICBILPI_01968 3.6e-31 yozC
HICBILPI_01970 2.4e-56 yozO S Bacterial PH domain
HICBILPI_01971 8.5e-37 yocN
HICBILPI_01972 3.8e-44 yozN
HICBILPI_01973 2e-88 yocM O Belongs to the small heat shock protein (HSP20) family
HICBILPI_01974 7.5e-09
HICBILPI_01975 1e-09 yocL
HICBILPI_01976 8.6e-55 dksA T general stress protein
HICBILPI_01978 2.2e-111 azoR I Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HICBILPI_01979 0.0 recQ 3.6.4.12 L DNA helicase
HICBILPI_01980 3.1e-108 yocH CBM50 M COG1388 FOG LysM repeat
HICBILPI_01982 5.5e-186 yocD 3.4.17.13 V peptidase S66
HICBILPI_01983 1.6e-93 yocC
HICBILPI_01984 1.2e-138 yocB J Protein required for attachment to host cells
HICBILPI_01985 3.6e-91 yozB S membrane
HICBILPI_01986 5.5e-121 pvaA M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)
HICBILPI_01987 8.4e-54 czrA K transcriptional
HICBILPI_01988 7.1e-92 yobW
HICBILPI_01989 7.2e-135 yobT S COG0491 Zn-dependent hydrolases, including glyoxylases
HICBILPI_01990 3.4e-92 yobS K Transcriptional regulator
HICBILPI_01991 4.3e-132 yobQ K helix_turn_helix, arabinose operon control protein
HICBILPI_01992 1.1e-53 csaA 6.1.1.10, 6.1.1.20, 6.1.1.6 J tRNA-binding protein
HICBILPI_01993 3.8e-60 ykvN K HxlR-like helix-turn-helix
HICBILPI_01994 1.9e-130 IQ Enoyl-(Acyl carrier protein) reductase
HICBILPI_01995 6.7e-44
HICBILPI_01996 1.5e-95 hpr K helix_turn_helix multiple antibiotic resistance protein
HICBILPI_01998 0.0 yoaE C belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HICBILPI_01999 5.3e-192 yoaD 1.1.1.399, 1.1.1.95 EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HICBILPI_02000 1.5e-267 yoaC 2.7.1.12, 2.7.1.17, 2.7.1.189 G FGGY family of carbohydrate kinases, C-terminal domain
HICBILPI_02001 1.3e-124 yoaB EGP Major facilitator Superfamily
HICBILPI_02002 5.2e-47 yoaB EGP Major facilitator Superfamily
HICBILPI_02003 2.3e-131 yoxB
HICBILPI_02004 2.4e-39 yoxC S protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HICBILPI_02005 1.1e-122 fabG 1.1.1.100 S Belongs to the short-chain dehydrogenases reductases (SDR) family
HICBILPI_02006 3.9e-60 rtp K Plays a role in DNA replication and termination (fork arrest mechanism). Two dimers of rtp bind to the two inverted repeat regions (IRI and IRII) present in the termination site. The binding of each dimer is centered on an 8 bp direct repeat
HICBILPI_02007 2.2e-140 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HICBILPI_02008 6.2e-202 proB 2.7.2.11 E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HICBILPI_02009 4.5e-150 gltC K Transcriptional regulator
HICBILPI_02010 0.0 gltB 1.4.1.13, 1.4.1.14, 1.4.7.1 E glutamate synthase
HICBILPI_02011 1.5e-291 gltD 1.4.1.13, 1.4.1.14 E COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases
HICBILPI_02012 4.8e-182 yogA C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases
HICBILPI_02013 1.2e-152 gltR1 K Transcriptional regulator
HICBILPI_02014 1.5e-14 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HICBILPI_02015 1.8e-50 ybzH K Helix-turn-helix domain
HICBILPI_02016 5.2e-199 ybcL EGP Major facilitator Superfamily
HICBILPI_02017 1.1e-161 ggt 2.3.2.2, 3.4.19.13 E gamma-glutamyltransferase
HICBILPI_02018 3.6e-155 ggt 2.3.2.2, 3.4.19.13 E gamma-glutamyltransferase
HICBILPI_02019 1.8e-34 yoeD G Helix-turn-helix domain
HICBILPI_02020 3.5e-97 L Integrase
HICBILPI_02022 1e-96 yoeB S IseA DL-endopeptidase inhibitor
HICBILPI_02023 6.7e-246 yoeA V MATE efflux family protein
HICBILPI_02024 1.3e-184 yoxA 5.1.3.3 G Aldose 1-epimerase
HICBILPI_02025 1.5e-267 dacC 3.4.16.4 M D-alanyl-D-alanine carboxypeptidase
HICBILPI_02026 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HICBILPI_02027 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HICBILPI_02028 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HICBILPI_02029 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HICBILPI_02030 0.0 Q D-alanine [D-alanyl carrier protein] ligase activity
HICBILPI_02031 1.2e-64 yngL S Protein of unknown function (DUF1360)
HICBILPI_02032 1.2e-301 yngK T Glycosyl hydrolase-like 10
HICBILPI_02033 3.7e-210 yngJ 1.3.8.1, 1.3.99.12 I acyl-CoA dehydrogenase
HICBILPI_02034 5.5e-297 yngI IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
HICBILPI_02035 2.1e-252 yngH 6.3.4.14, 6.4.1.2, 6.4.1.3, 6.4.1.4 I Biotin carboxylase
HICBILPI_02036 2.4e-30 pycB 2.3.1.12, 6.4.1.1 I Biotin carboxyl carrier protein
HICBILPI_02037 1.3e-165 mvaB 4.1.3.4, 6.4.1.4 E Hydroxymethylglutaryl-CoA lyase
HICBILPI_02038 3.8e-135 yngF 4.2.1.17 I Belongs to the enoyl-CoA hydratase isomerase family
HICBILPI_02039 5.7e-291 yngE 2.1.3.15, 6.4.1.3 I COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
HICBILPI_02040 3.2e-104 yngC S SNARE associated Golgi protein
HICBILPI_02041 2.6e-158 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
HICBILPI_02042 9.6e-68 yngA S membrane
HICBILPI_02044 2.3e-107 bioW 2.3.1.47, 6.2.1.14 H Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
HICBILPI_02045 9.6e-258 bioA 2.6.1.105, 2.6.1.62 H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor
HICBILPI_02046 2.6e-211 bioF 2.3.1.29, 2.3.1.47, 6.2.1.14 H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide
HICBILPI_02047 2.4e-57 bioD 6.3.3.3 H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HICBILPI_02048 4.3e-46 bioD 6.3.3.3 H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HICBILPI_02049 8.2e-193 bioB 2.8.1.6 H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HICBILPI_02050 5.6e-217 bioI 1.14.14.46 C Cytochrome P450
HICBILPI_02051 1.9e-251 yxjC EG COG2610 H gluconate symporter and related permeases
HICBILPI_02052 1.3e-125 scoA 2.8.3.5 I COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HICBILPI_02053 2.4e-121 scoB 2.8.3.5 I COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit
HICBILPI_02054 1.4e-136 IQ Catalyzes the formation of acetoacetate from 3-hydroxybutyrate
HICBILPI_02055 3e-218 fabD 2.3.1.39 I malonyl CoA-acyl carrier protein transacylase
HICBILPI_02056 0.0 nrsA Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HICBILPI_02057 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HICBILPI_02058 6.1e-90 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HICBILPI_02059 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HICBILPI_02060 4.7e-293 xynD3 3.2.1.55 CBM6,GH43 G Belongs to the glycosyl hydrolase 43 family
HICBILPI_02061 2.4e-250 xynC 3.2.1.136 GH5 G Glycosyl hydrolase family 30 beta sandwich domain
HICBILPI_02062 8.4e-128 T Transcriptional regulatory protein, C terminal
HICBILPI_02063 2.6e-229 T PhoQ Sensor
HICBILPI_02064 1.2e-49 S Domain of unknown function (DUF4870)
HICBILPI_02065 1.1e-200 bglC5 3.2.1.4 GH5,GH9 G PFAM glycoside hydrolase family 5
HICBILPI_02066 8.9e-74 bglC5 3.2.1.4 GH5,GH9 G PFAM glycoside hydrolase family 5
HICBILPI_02067 7.2e-80 S Platelet-activating factor acetylhydrolase, isoform II
HICBILPI_02068 7.4e-297 yndJ S YndJ-like protein
HICBILPI_02069 7.3e-80 yndH S Domain of unknown function (DUF4166)
HICBILPI_02070 3.5e-154 yndG S DoxX-like family
HICBILPI_02071 2.9e-219 exuT G Sugar (and other) transporter
HICBILPI_02072 5.1e-179 kdgR_1 K transcriptional
HICBILPI_02073 2.2e-143 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
HICBILPI_02074 1.1e-211 uxuA 4.2.1.8 G Catalyzes the dehydration of D-mannonate
HICBILPI_02075 1.5e-112 eda 4.1.2.14, 4.1.3.42 G 2-dehydro-3-deoxy-phosphogluconate aldolase
HICBILPI_02076 1.3e-190 rspB 1.1.1.380 E Alcohol dehydrogenase GroES-like domain
HICBILPI_02077 3.3e-180 kdgK 2.7.1.45 G COG0524 Sugar kinases, ribokinase family
HICBILPI_02078 1.2e-245 agcS E Sodium alanine symporter
HICBILPI_02079 5.1e-41 ynfC
HICBILPI_02080 6e-13
HICBILPI_02081 0.0 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HICBILPI_02082 0.0 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HICBILPI_02083 1.5e-68 yccU S CoA-binding protein
HICBILPI_02084 4.2e-93 plsY 2.3.1.15, 3.5.1.104 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
HICBILPI_02085 1.1e-49 yneR S Belongs to the HesB IscA family
HICBILPI_02086 4.1e-52 yneQ
HICBILPI_02087 8.3e-75 yneP S Thioesterase-like superfamily
HICBILPI_02088 7.1e-18 tlp S Belongs to the Tlp family
HICBILPI_02090 3.7e-93 yneN CO alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HICBILPI_02091 0.0 acnA 4.2.1.3 C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HICBILPI_02092 7.5e-15 sspO S Belongs to the SspO family
HICBILPI_02093 2.3e-19 sspP S Belongs to the SspP family
HICBILPI_02094 1.1e-62 hspX O Spore coat protein
HICBILPI_02095 2.5e-74 yneK S Protein of unknown function (DUF2621)
HICBILPI_02096 4.3e-75 yneJ O COG4846 Membrane protein involved in cytochrome C biogenesis
HICBILPI_02097 3e-57 cheB 3.1.1.61, 3.5.1.44 T cheY-homologous receiver domain
HICBILPI_02098 1.7e-125 ccdA O cytochrome c biogenesis protein
HICBILPI_02099 3.1e-23 ynzD S Spo0E like sporulation regulatory protein
HICBILPI_02100 2.3e-28 yneF S UPF0154 protein
HICBILPI_02101 1.3e-81 yneE S Sporulation inhibitor of replication protein sirA
HICBILPI_02102 0.0 tkt 2.2.1.1 G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HICBILPI_02103 9.8e-33 ynzC S UPF0291 protein
HICBILPI_02104 3.5e-112 yneB L resolvase
HICBILPI_02105 6.2e-51 yneA D Inhibits cell division during the SOS response. Affects a later stage of the cell division protein assembly, after the assembly of the Z ring, by probably suppressing recruitment of FtsL and or DivIC to the division machinery
HICBILPI_02106 2.6e-109 lexA 3.4.21.88 K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HICBILPI_02107 2.1e-12 yoaW
HICBILPI_02108 1.2e-71 yndM S Protein of unknown function (DUF2512)
HICBILPI_02109 1.6e-138 O COG0330 Membrane protease subunits, stomatin prohibitin homologs
HICBILPI_02110 9.1e-08
HICBILPI_02111 2.6e-141 yndL S Replication protein
HICBILPI_02112 1.4e-77 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F Deoxyuridine 5'-triphosphate
HICBILPI_02113 0.0 yobO M Pectate lyase superfamily protein
HICBILPI_02115 5.6e-92 yvgO
HICBILPI_02118 1.2e-117 AA10,CBM73 S Pfam:Chitin_bind_3
HICBILPI_02119 1.1e-200 C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HICBILPI_02120 3.1e-84 ynaE S Domain of unknown function (DUF3885)
HICBILPI_02121 6.3e-99 J Acetyltransferase (GNAT) domain
HICBILPI_02122 1.7e-142 yoaP 3.1.3.18 K YoaP-like
HICBILPI_02125 1.1e-09
HICBILPI_02126 7.4e-186 adhP 1.1.1.1 C alcohol dehydrogenase
HICBILPI_02130 2.9e-24 pps 2.7.9.2 GT phosphoenolpyruvate synthase
HICBILPI_02131 0.0 pps 2.7.9.2 GT phosphoenolpyruvate synthase
HICBILPI_02132 6.2e-207 xylB 2.7.1.12, 2.7.1.17, 2.7.1.189 G xylulose kinase
HICBILPI_02133 1.5e-60 xylB 2.7.1.12, 2.7.1.17, 2.7.1.189 G xylulose kinase
HICBILPI_02134 1.4e-261 xylA 5.3.1.5 G Belongs to the xylose isomerase family
HICBILPI_02135 1.6e-208 xylR GK ROK family
HICBILPI_02136 3.5e-168 xynB 3.2.1.37 GH43 G Belongs to the glycosyl hydrolase 43 family
HICBILPI_02137 5e-133 xynB 3.2.1.37 GH43 G Belongs to the glycosyl hydrolase 43 family
HICBILPI_02138 2.8e-97 xynT G MFS/sugar transport protein
HICBILPI_02139 1.2e-81 xynT G MFS/sugar transport protein
HICBILPI_02140 1.7e-207 mrjp G Major royal jelly protein
HICBILPI_02141 4.1e-261 glnA 6.3.1.2 E glutamine synthetase
HICBILPI_02142 4.3e-68 glnR K transcriptional
HICBILPI_02143 4.8e-243 ynbB 4.4.1.1 P COG4100 Cystathionine beta-lyase family protein involved in aluminum resistance
HICBILPI_02144 1.1e-231 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HICBILPI_02145 1.3e-176 spoVK O stage V sporulation protein K
HICBILPI_02146 1.4e-112 cwlC 3.5.1.28 M n-acetylmuramoyl-L-alanine amidase
HICBILPI_02147 6.5e-108 ymaB S MutT family
HICBILPI_02148 1.4e-184 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HICBILPI_02149 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HICBILPI_02150 3.9e-66 nrdI 1.17.4.1 F Probably involved in ribonucleotide reductase function
HICBILPI_02151 1.8e-20 ymzA
HICBILPI_02152 1.8e-41
HICBILPI_02153 1.1e-33 hfq J RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs
HICBILPI_02154 4.3e-172 miaA 2.5.1.75 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HICBILPI_02155 9.2e-47 ymaF S YmaF family
HICBILPI_02157 2.6e-47 ebrA P Small Multidrug Resistance protein
HICBILPI_02158 2.6e-53 ebrB P Small Multidrug Resistance protein
HICBILPI_02159 6e-79 ymaD O redox protein, regulator of disulfide bond formation
HICBILPI_02160 8.7e-125 ymaC S Replication protein
HICBILPI_02161 1.7e-254 aprX O Belongs to the peptidase S8 family
HICBILPI_02162 4.1e-62 ymzB
HICBILPI_02163 1.6e-64 yoaK S Membrane
HICBILPI_02164 4.3e-38 yoaK S Membrane
HICBILPI_02165 1.9e-77 nucB M Deoxyribonuclease NucA/NucB
HICBILPI_02166 6.8e-59 cypA C Cytochrome P450
HICBILPI_02167 4.3e-158 cypA C Cytochrome P450
HICBILPI_02168 0.0 pks13 HQ Beta-ketoacyl synthase
HICBILPI_02169 0.0 dhbF IQ polyketide synthase
HICBILPI_02170 0.0 dhbF IQ polyketide synthase
HICBILPI_02171 0.0 pfaA 4.1.1.35 GT4 Q Polyketide synthase of type I
HICBILPI_02172 0.0 Q Polyketide synthase of type I
HICBILPI_02173 4.4e-233 rhiB IQ polyketide synthase
HICBILPI_02174 0.0 rhiB IQ polyketide synthase
HICBILPI_02175 2.9e-139 pksI I Belongs to the enoyl-CoA hydratase isomerase family
HICBILPI_02176 9.1e-144 pksH 4.2.1.18 I enoyl-CoA hydratase
HICBILPI_02177 2.4e-242 pksG 2.3.3.10 I synthase
HICBILPI_02178 5.5e-34 acpK IQ Phosphopantetheine attachment site
HICBILPI_02179 0.0 fabD 1.13.12.16, 2.3.1.39 I malonyl CoA-acyl carrier protein transacylase
HICBILPI_02180 1.6e-182 pksD Q Acyl transferase domain
HICBILPI_02181 5.4e-161 fabD 2.3.1.39 I malonyl CoA-acyl carrier protein transacylase
HICBILPI_02182 3.3e-129 pksB 3.1.2.6 S Polyketide biosynthesis
HICBILPI_02184 0.0 mutL L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HICBILPI_02185 0.0 mutS L that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HICBILPI_02186 1.7e-88 cotE S Spore coat protein
HICBILPI_02187 4.6e-68 ymcA 3.6.3.21 S Belongs to the UPF0342 family
HICBILPI_02188 2.2e-295 miaB 2.8.4.3 J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HICBILPI_02189 2.6e-214 kbl 2.3.1.29, 2.3.1.47 H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide
HICBILPI_02190 2.4e-195 tdh 1.1.1.103 C Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate
HICBILPI_02191 1.2e-36 spoVS S Stage V sporulation protein S
HICBILPI_02192 4.9e-153 ymdB S protein conserved in bacteria
HICBILPI_02193 4.2e-241 rny S Endoribonuclease that initiates mRNA decay
HICBILPI_02194 3.3e-193 pbpX V Beta-lactamase
HICBILPI_02195 6.2e-188 recA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HICBILPI_02196 1.2e-230 cinA 3.5.1.42 S Belongs to the CinA family
HICBILPI_02197 1.4e-101 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HICBILPI_02198 1.9e-124 ymfM S protein conserved in bacteria
HICBILPI_02199 1e-142 ymfK S Protein of unknown function (DUF3388)
HICBILPI_02200 9.7e-42 ymfJ S Protein of unknown function (DUF3243)
HICBILPI_02201 6.6e-128 ymfI 1.1.1.100, 1.3.1.28 S Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
HICBILPI_02202 3.5e-241 ymfH S zinc protease
HICBILPI_02203 1.3e-235 ymfF S Peptidase M16
HICBILPI_02204 0.0 ydgH S drug exporters of the RND superfamily
HICBILPI_02205 2.1e-76 K helix_turn_helix multiple antibiotic resistance protein
HICBILPI_02206 3e-227 ymfD EGP Major facilitator Superfamily
HICBILPI_02207 4.4e-132 ymfC K Transcriptional regulator
HICBILPI_02208 0.0 ftsK D Belongs to the FtsK SpoIIIE SftA family
HICBILPI_02209 6.3e-31 S YlzJ-like protein
HICBILPI_02210 4.5e-129 tepA 3.4.21.92 OU COG0740 Protease subunit of ATP-dependent Clp proteases
HICBILPI_02211 2e-308 rnjB S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HICBILPI_02212 6.2e-157 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HICBILPI_02213 1.6e-219 dapG 1.1.1.3, 2.7.2.4 E Belongs to the aspartokinase family
HICBILPI_02214 4.9e-193 asd 1.2.1.11 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HICBILPI_02215 5.7e-106 spoVFB H Together with DpaA, catalyzes the conversion of dihydrodipicolinate to dipicolinate (DPA)
HICBILPI_02216 1e-159 spoVFA 1.1.1.29, 1.1.1.399, 1.1.1.95 CH Dipicolinate synthase subunit A
HICBILPI_02217 2.6e-42 ymxH S YlmC YmxH family
HICBILPI_02218 1.2e-233 pepR S Belongs to the peptidase M16 family
HICBILPI_02219 5.7e-180 ylxY 3.5.1.104 G Sporulation protein, polysaccharide deacetylase
HICBILPI_02220 0.0 pnp 2.7.7.8 J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
HICBILPI_02221 1e-41 rpsO J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HICBILPI_02222 6e-182 ribF 2.7.1.26, 2.7.7.2 H Belongs to the ribF family
HICBILPI_02223 4.3e-172 truB 5.4.99.25 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HICBILPI_02224 3.3e-56 rbfA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HICBILPI_02225 3.9e-44 ylxP S protein conserved in bacteria
HICBILPI_02226 0.0 infB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HICBILPI_02227 1.8e-47 ylxQ J ribosomal protein
HICBILPI_02228 1.7e-36 ylxR K nucleic-acid-binding protein implicated in transcription termination
HICBILPI_02229 5.4e-206 nusA K Participates in both transcription termination and antitermination
HICBILPI_02230 2.5e-80 rimP S Required for maturation of 30S ribosomal subunits
HICBILPI_02231 7.6e-191 polC 2.7.7.7 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HICBILPI_02232 0.0 polC 2.7.7.7 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HICBILPI_02233 4.9e-179 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
HICBILPI_02234 9.4e-119 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
HICBILPI_02235 1.5e-233 rasP M zinc metalloprotease
HICBILPI_02236 2.5e-214 dxr 1.1.1.267 I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
HICBILPI_02237 2e-138 cdsA 2.7.7.41 S Belongs to the CDS family
HICBILPI_02238 6.4e-145 uppS 2.5.1.31 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HICBILPI_02239 1.9e-90 frr J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
HICBILPI_02240 9.4e-127 pyrH 2.7.4.22 F Catalyzes the reversible phosphorylation of UMP to UDP
HICBILPI_02241 4.5e-155 tsf J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HICBILPI_02242 3.8e-131 rpsB J Belongs to the universal ribosomal protein uS2 family
HICBILPI_02243 8e-50 ylxL
HICBILPI_02244 3.9e-139 sigD K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HICBILPI_02245 5.1e-87 cheD 3.5.1.44 NT Deamidates glutamine residues to glutamate on methyl- accepting chemotaxis receptors (MCPs). CheD-mediated MCP deamidation is required for productive communication of the conformational signals of the chemoreceptors to the CheA kinase
HICBILPI_02246 1.8e-110 cheC NT COG1776 Chemotaxis protein CheC, inhibitor of MCP methylation
HICBILPI_02247 8.8e-81 cheW NT COG0835 Chemotaxis signal transduction protein
HICBILPI_02248 0.0 cheA 2.7.13.3 NT COG0643 Chemotaxis protein histidine kinase and related kinases
HICBILPI_02249 2.5e-192 cheB 3.1.1.61, 3.5.1.44 NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR
HICBILPI_02250 4.1e-156 flhG D Belongs to the ParA family
HICBILPI_02251 2.2e-191 flhF N Flagellar biosynthesis regulator FlhF
HICBILPI_02252 0.0 flhA N Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HICBILPI_02253 7.6e-189 flhB N Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HICBILPI_02254 5.2e-131 fliR N Flagellar biosynthetic protein FliR
HICBILPI_02255 2e-37 fliQ N Role in flagellar biosynthesis
HICBILPI_02256 3.7e-109 fliP N Plays a role in the flagellum-specific transport system
HICBILPI_02257 2.5e-110 fliZ N Flagellar biosynthesis protein, FliO
HICBILPI_02258 1.2e-58 cheB 3.1.1.61, 3.5.1.44 T response regulator
HICBILPI_02259 4e-188 fliN N FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HICBILPI_02260 5.4e-181 fliM N One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation
HICBILPI_02261 2.4e-58 fliL N Controls the rotational direction of flagella during chemotaxis
HICBILPI_02262 5.7e-138 flgG N Flagellar basal body rod
HICBILPI_02263 4.1e-72 flgD N Flagellar basal body rod modification protein
HICBILPI_02264 2.3e-203 fliK N Flagellar hook-length control protein
HICBILPI_02265 4.8e-47 ylxF S MgtE intracellular N domain
HICBILPI_02266 2e-71 fliJ N Flagellar biosynthesis chaperone
HICBILPI_02267 8.5e-243 fliI 3.6.3.14 NU COG1157 Flagellar biosynthesis type III secretory pathway ATPase
HICBILPI_02268 1.5e-87 fliH NU COG1317 Flagellar biosynthesis type III secretory pathway protein
HICBILPI_02269 1.3e-177 fliG N One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation
HICBILPI_02270 1.4e-263 fliF N The M ring may be actively involved in energy transduction
HICBILPI_02271 2.5e-31 fliE N Flagellar hook-basal body
HICBILPI_02272 8.1e-76 flgC N Belongs to the flagella basal body rod proteins family
HICBILPI_02273 2e-54 flgB N Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body
HICBILPI_02274 1.2e-135 codY K DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HICBILPI_02275 4e-230 hslU O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HICBILPI_02276 6.7e-93 hslV 3.4.25.2 O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HICBILPI_02277 1.6e-171 xerC L tyrosine recombinase XerC
HICBILPI_02278 2.2e-246 trmFO 2.1.1.74 J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HICBILPI_02279 0.0 topA 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HICBILPI_02280 1.2e-168 dprA LU Rossmann fold nucleotide-binding protein involved in DNA uptake
HICBILPI_02281 1.1e-167 sucD 6.2.1.5 C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HICBILPI_02282 6.8e-212 sucC 6.2.1.5 C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
HICBILPI_02283 2.5e-43 ylqH S homolog of the cytoplasmic domain of flagellar protein FhlB
HICBILPI_02284 4.7e-302 ylqG
HICBILPI_02285 1.5e-127 rnhB 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HICBILPI_02286 3.2e-158 ylqF S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HICBILPI_02287 1.9e-56 rplS J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
HICBILPI_02288 1.6e-137 trmD 2.1.1.228, 4.6.1.12 J Belongs to the RNA methyltransferase TrmD family
HICBILPI_02289 2e-94 rimM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HICBILPI_02290 1.3e-61 ylqD S YlqD protein
HICBILPI_02291 1.7e-35 ylqC S Belongs to the UPF0109 family
HICBILPI_02292 1.4e-43 rpsP J Belongs to the bacterial ribosomal protein bS16 family
HICBILPI_02293 7.6e-223 ffh 3.6.5.4 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HICBILPI_02294 4.3e-50 ylxM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HICBILPI_02295 7.9e-140 S Phosphotransferase enzyme family
HICBILPI_02296 2.8e-174 ftsY U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HICBILPI_02297 0.0 smc D Required for chromosome condensation and partitioning
HICBILPI_02298 3.7e-134 rnc 3.1.26.3 J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
HICBILPI_02299 2.8e-32 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
HICBILPI_02300 4.6e-129 IQ reductase
HICBILPI_02301 2e-169 fabD 2.3.1.39 I malonyl CoA-acyl carrier protein transacylase
HICBILPI_02302 3.6e-177 plsX 2.3.1.15 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
HICBILPI_02303 2e-92 fapR K Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism
HICBILPI_02304 0.0 recG 3.6.4.12 L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HICBILPI_02305 4.6e-155 sdaAA 4.3.1.17 E L-serine dehydratase
HICBILPI_02306 1.6e-117 sdaAB 4.3.1.17 E L-serine dehydratase
HICBILPI_02307 1.1e-292 yloV S kinase related to dihydroxyacetone kinase
HICBILPI_02308 5.5e-59 asp S protein conserved in bacteria
HICBILPI_02309 1.4e-26 rpmB J Belongs to the bacterial ribosomal protein bL28 family
HICBILPI_02310 5.8e-120 thiN 2.7.6.2 H thiamine pyrophosphokinase
HICBILPI_02311 3e-116 rpe 5.1.3.1 G Belongs to the ribulose-phosphate 3-epimerase family
HICBILPI_02312 4.8e-165 rsgA 3.1.3.100 S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
HICBILPI_02313 0.0 prkC 2.7.11.1 KLT serine threonine protein kinase
HICBILPI_02314 3.3e-138 stp 3.1.3.16 T phosphatase
HICBILPI_02315 9e-206 rlmN 2.1.1.192, 2.1.1.224 J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HICBILPI_02316 7.9e-252 sun 2.1.1.176 J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HICBILPI_02317 6.2e-171 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HICBILPI_02318 5.1e-84 def 2.1.2.9, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
HICBILPI_02319 0.0 priA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HICBILPI_02320 3.3e-225 coaBC 4.1.1.36, 6.3.2.5 H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HICBILPI_02321 2.8e-28 rpoZ 2.7.7.6 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
HICBILPI_02322 8.1e-111 gmk 2.7.4.8 F Essential for recycling GMP and indirectly, cGMP
HICBILPI_02323 1.5e-40 ylzA S Belongs to the UPF0296 family
HICBILPI_02324 8.5e-154 yloC S stress-induced protein
HICBILPI_02325 0.0 yloB 3.6.3.8 P COG0474 Cation transport ATPase
HICBILPI_02326 0.0 FbpA K RNA-binding protein homologous to eukaryotic snRNP
HICBILPI_02327 5.1e-76 cysG 1.3.1.76, 4.99.1.4 H Siroheme synthase
HICBILPI_02328 5.4e-144 cbiX 4.99.1.3, 4.99.1.4, 5.4.99.60, 5.4.99.61 S Sirohydrochlorin ferrochelatase
HICBILPI_02329 3.8e-142 hemD 2.1.1.107, 4.2.1.75 H Belongs to the precorrin methyltransferase family
HICBILPI_02330 1.6e-108 cysC 2.7.1.25 P Catalyzes the synthesis of activated sulfate
HICBILPI_02331 5e-223 sat 2.7.7.4 P Belongs to the sulfate adenylyltransferase family
HICBILPI_02332 1.1e-176 cysP P phosphate transporter
HICBILPI_02333 3.8e-141 cysH 1.8.4.10, 1.8.4.8, 2.7.1.25 EH Belongs to the PAPS reductase family. CysH subfamily
HICBILPI_02335 6.1e-114 pyrE 2.4.2.10, 4.1.1.23 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HICBILPI_02336 1.2e-126 pyrF 4.1.1.23 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
HICBILPI_02337 1.1e-172 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
HICBILPI_02338 2.6e-143 pyrK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )
HICBILPI_02339 0.0 carB 6.3.5.5 F Belongs to the CarB family
HICBILPI_02340 3.6e-210 carA 6.3.5.5 F Carbamoyl-phosphate synthetase glutamine chain
HICBILPI_02341 4.7e-246 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
HICBILPI_02342 5.9e-166 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
HICBILPI_02343 5.2e-232 pyrP F Xanthine uracil
HICBILPI_02344 8e-94 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HICBILPI_02345 5.1e-162 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
HICBILPI_02346 5.2e-78 lspA 3.4.23.36 MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HICBILPI_02347 1.2e-61 dksA T COG1734 DnaK suppressor protein
HICBILPI_02348 0.0 ileS 6.1.1.5 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HICBILPI_02349 8.9e-68 divIVA D Cell division initiation protein
HICBILPI_02350 1.6e-140 ylmH 5.4.99.23, 5.4.99.24 S conserved protein, contains S4-like domain
HICBILPI_02351 5.2e-41 yggT S membrane
HICBILPI_02352 4.8e-60 sepF D Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
HICBILPI_02353 2.1e-123 ylmE S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HICBILPI_02354 5.4e-144 yfiH S Belongs to the multicopper oxidase YfiH RL5 family
HICBILPI_02355 5.8e-37 ylmC S sporulation protein
HICBILPI_02356 1.9e-251 argE 3.5.1.16 E Acetylornithine deacetylase
HICBILPI_02357 1.2e-143 modF 3.6.3.21, 3.6.3.34 P COG1119 ABC-type molybdenum transport system, ATPase component photorepair protein PhrA
HICBILPI_02358 1.1e-139 sigG K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HICBILPI_02359 6.8e-117 sigE K sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HICBILPI_02360 4.1e-159 spoIIGA M aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR
HICBILPI_02361 0.0 bpr O COG1404 Subtilisin-like serine proteases
HICBILPI_02362 2e-223 bpr O COG1404 Subtilisin-like serine proteases
HICBILPI_02363 1.2e-203 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HICBILPI_02364 5.3e-88 ftsA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
HICBILPI_02365 1.7e-117 ftsA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
HICBILPI_02366 4.8e-132 divIB D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
HICBILPI_02367 1.8e-167 murB 1.3.1.98 M cell wall formation
HICBILPI_02368 2.1e-202 murG 2.4.1.227, 6.3.2.8 GT28 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HICBILPI_02369 2.2e-185 spoVE D Belongs to the SEDS family
HICBILPI_02370 6.5e-254 murD 6.3.2.9 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HICBILPI_02371 1.7e-171 mraY 2.7.8.13 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HICBILPI_02372 2.6e-280 murE 6.3.2.10, 6.3.2.13 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HICBILPI_02373 0.0 ftsI 3.4.16.4 M stage V sporulation protein D
HICBILPI_02374 0.0 ftsI 3.4.16.4 M Penicillin-binding Protein
HICBILPI_02375 2.9e-52 ftsL D Essential cell division protein
HICBILPI_02376 7.3e-172 rsmH 2.1.1.199 J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
HICBILPI_02377 1.2e-77 mraZ K Belongs to the MraZ family
HICBILPI_02378 7.4e-308 bshC S Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HICBILPI_02379 1.6e-163 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HICBILPI_02380 1.5e-88 ylbP K n-acetyltransferase
HICBILPI_02381 3.4e-71 ylbO S SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
HICBILPI_02382 1.2e-27 rpmF J Belongs to the bacterial ribosomal protein bL32 family
HICBILPI_02383 5.6e-89 yceD S metal-binding, possibly nucleic acid-binding protein
HICBILPI_02384 7.3e-228 ylbM S Belongs to the UPF0348 family
HICBILPI_02385 1e-187 ylbL T Belongs to the peptidase S16 family
HICBILPI_02386 2e-138 ylbK S esterase of the alpha-beta hydrolase superfamily
HICBILPI_02387 2.2e-216 ylbJ S Sporulation integral membrane protein YlbJ
HICBILPI_02388 9.5e-83 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HICBILPI_02389 6e-97 rsmD 2.1.1.171 L Methyltransferase
HICBILPI_02391 5.5e-43 ylbG S UPF0298 protein
HICBILPI_02392 1.2e-71 ylbF S Belongs to the UPF0342 family
HICBILPI_02393 8.8e-37 ylbE S YlbE-like protein
HICBILPI_02394 2.1e-54 ylbD S Putative coat protein
HICBILPI_02395 2.3e-198 ylbC S protein with SCP PR1 domains
HICBILPI_02396 2.2e-73 ylbB T COG0517 FOG CBS domain
HICBILPI_02397 3.2e-59 ylbA S YugN-like family
HICBILPI_02398 2e-163 ctaG S cytochrome c oxidase
HICBILPI_02399 1.9e-50 ctaF 1.10.3.12, 1.9.3.1 C COG3125 Heme copper-type cytochrome quinol oxidase, subunit 4
HICBILPI_02400 2.4e-110 cyoC 1.10.3.12, 1.9.3.1 C COG1845 Heme copper-type cytochrome quinol oxidase, subunit 3
HICBILPI_02401 0.0 ctaD 1.10.3.12, 1.9.3.1 C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HICBILPI_02402 1.2e-189 ctaC 1.9.3.1 C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)
HICBILPI_02403 3.2e-164 ctaB 2.5.1.141 O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
HICBILPI_02404 2e-166 ctaA 2.5.1.141 O Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group
HICBILPI_02405 0.0 pyc 6.4.1.1 C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HICBILPI_02406 1.9e-212 ftsW D Belongs to the SEDS family
HICBILPI_02407 8.7e-44 ylaN S Belongs to the UPF0358 family
HICBILPI_02408 3.9e-173 glsA 3.5.1.2 E Belongs to the glutaminase family
HICBILPI_02409 9.4e-83 ylaL S Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HICBILPI_02410 8.6e-243 phoH T ATPase related to phosphate starvation-inducible protein PhoH
HICBILPI_02411 2.6e-104 ylaJ S Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
HICBILPI_02412 1.4e-33 ylaI S protein conserved in bacteria
HICBILPI_02413 6.6e-48 ylaH S YlaH-like protein
HICBILPI_02414 0.0 typA T GTP-binding protein TypA
HICBILPI_02415 6.7e-24 S Family of unknown function (DUF5325)
HICBILPI_02416 1.3e-36 ylaE
HICBILPI_02417 2.2e-13 sigC S Putative zinc-finger
HICBILPI_02418 2.2e-293 mpl 3.4.24.28, 3.4.24.29 E Peptidase M4
HICBILPI_02419 4e-83 ykzC S Acetyltransferase (GNAT) family
HICBILPI_02420 4.6e-151 suhB 3.1.3.25 G Inositol monophosphatase
HICBILPI_02421 6.3e-24 ykzI
HICBILPI_02422 1.8e-118 yktB S Belongs to the UPF0637 family
HICBILPI_02423 1.6e-42 yktA S Belongs to the UPF0223 family
HICBILPI_02424 3.2e-275 speA 4.1.1.19 E Arginine
HICBILPI_02425 1e-134 pdaA_2 3.5.1.104 G Polysaccharide deacetylase
HICBILPI_02426 8.8e-44 slp CO COG0526, thiol-disulfide isomerase and thioredoxins
HICBILPI_02427 5.4e-251 lpdA 1.8.1.4 C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
HICBILPI_02428 4.6e-228 pdhC 2.3.1.12 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
HICBILPI_02429 1.4e-178 pdhB 1.2.4.1, 1.2.4.4 C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
HICBILPI_02430 2.3e-204 pdhA 1.2.4.1, 1.2.4.4 C COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
HICBILPI_02431 3.3e-208 V Beta-lactamase
HICBILPI_02432 1.4e-226 bioH 2.1.1.197, 3.1.1.85, 4.2.99.20 IQ Phosphopantetheine attachment site
HICBILPI_02433 0.0 bioH 2.1.1.197, 3.1.1.85, 4.2.99.20 IQ Phosphopantetheine attachment site
HICBILPI_02434 0.0 Q Polyketide synthase of type I
HICBILPI_02435 0.0 Q Polyketide synthase of type I
HICBILPI_02436 0.0 Q Polyketide synthase of type I
HICBILPI_02437 0.0 Q Polyketide synthase of type I
HICBILPI_02438 0.0 Q polyketide synthase
HICBILPI_02439 0.0 Q Polyketide synthase of type I
HICBILPI_02440 0.0 Q Polyketide synthase of type I
HICBILPI_02441 0.0 fabD 1.13.12.16, 2.3.1.39 I malonyl CoA-acyl carrier protein transacylase
HICBILPI_02442 1.4e-72 fabD 1.13.12.16, 2.3.1.39 I malonyl CoA-acyl carrier protein transacylase
HICBILPI_02443 1.6e-101 recN L Putative cell-wall binding lipoprotein
HICBILPI_02445 1.2e-100 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
HICBILPI_02446 7.4e-146 ykrA S hydrolases of the HAD superfamily
HICBILPI_02447 8.2e-31 ykzG S Belongs to the UPF0356 family
HICBILPI_02448 0.0 rnjA S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HICBILPI_02449 0.0 ade 3.5.4.2 F Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HICBILPI_02450 2e-115 ktrA P COG0569 K transport systems, NAD-binding component
HICBILPI_02451 1.9e-147 ykqA P Gamma-glutamyl cyclotransferase, AIG2-like
HICBILPI_02452 3.4e-244 kinC 2.7.13.3 T COG0642 Signal transduction histidine kinase
HICBILPI_02453 1.8e-44 abrB K of stationary sporulation gene expression
HICBILPI_02454 6.9e-184 mreB D Rod-share determining protein MreBH
HICBILPI_02455 3.6e-235 ampS E COG2309 Leucyl aminopeptidase (aminopeptidase T)
HICBILPI_02456 1.7e-165 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HICBILPI_02457 1.1e-308 ybiT S COG0488 ATPase components of ABC transporters with duplicated ATPase domains
HICBILPI_02458 7.4e-11 ykoA
HICBILPI_02459 1.5e-106 sipT 3.4.21.89 U Belongs to the peptidase S26 family
HICBILPI_02460 0.0 fruA 2.7.1.202 GT COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type)
HICBILPI_02461 1.8e-167 fruK 2.7.1.11, 2.7.1.56 G Belongs to the carbohydrate kinase PfkB family
HICBILPI_02462 1.7e-131 fruR K Transcriptional regulator
HICBILPI_02463 3e-210 yknZ V ABC transporter (permease)
HICBILPI_02464 2e-121 macB V ABC transporter, ATP-binding protein
HICBILPI_02465 6e-168 acrA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HICBILPI_02466 7.5e-105 yknW S Yip1 domain
HICBILPI_02467 5.7e-33 moaD 2.8.1.12 H Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HICBILPI_02468 6e-82 moaE 2.8.1.12 H COG0314 Molybdopterin converting factor, large subunit
HICBILPI_02469 1.9e-92 mobB 2.10.1.1, 2.7.7.77 H molybdopterin-guanine dinucleotide biosynthesis protein
HICBILPI_02470 1.7e-243 moeA 2.10.1.1 H molybdopterin
HICBILPI_02471 1.1e-189 moeB 2.7.7.73, 2.7.7.80 H COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
HICBILPI_02472 2.8e-108 mobA 2.7.7.77 H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
HICBILPI_02473 1.8e-160 yknT
HICBILPI_02474 4.5e-98 rok K Repressor of ComK
HICBILPI_02475 2.2e-76 ykuV CO thiol-disulfide
HICBILPI_02476 3.7e-140 ykuT M Mechanosensitive ion channel
HICBILPI_02477 4.8e-38 ykuS S Belongs to the UPF0180 family
HICBILPI_02478 6.4e-215 hipO 3.5.1.47 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
HICBILPI_02479 2.6e-76 dapD 2.3.1.117, 2.3.1.89 E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
HICBILPI_02480 3.9e-78 fld C Flavodoxin
HICBILPI_02481 1.4e-164 ykuO
HICBILPI_02482 1.3e-89 fld C Flavodoxin
HICBILPI_02483 1.3e-167 ccpC K Transcriptional regulator
HICBILPI_02484 1e-75 ykuL S CBS domain
HICBILPI_02485 2.1e-25 ykzF S Antirepressor AbbA
HICBILPI_02486 1.4e-92 ykuK S Ribonuclease H-like
HICBILPI_02487 3.9e-37 ykuJ S protein conserved in bacteria
HICBILPI_02488 3.3e-233 ykuI T Diguanylate phosphodiesterase
HICBILPI_02490 1.3e-142 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HICBILPI_02491 2e-152 ykuE S Metallophosphoesterase
HICBILPI_02492 1.6e-88 ykuD S protein conserved in bacteria
HICBILPI_02493 6.6e-240 ykuC EGP Major facilitator Superfamily
HICBILPI_02494 1.4e-83 ykyB S YkyB-like protein
HICBILPI_02495 5.3e-167 cheV 2.7.13.3 T Chemotaxis protein CheV
HICBILPI_02496 2.3e-09
HICBILPI_02497 3.9e-215 patA 2.6.1.1 E Aminotransferase
HICBILPI_02498 1.2e-290 pilS 2.1.1.80, 2.7.13.3, 3.1.1.61 T Histidine kinase
HICBILPI_02499 0.0 mrdA 3.4.16.4 M Penicillin-binding Protein
HICBILPI_02500 1.5e-114 ykwD J protein with SCP PR1 domains
HICBILPI_02501 2.1e-157 glxR 1.1.1.31, 1.1.1.60 I COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases
HICBILPI_02502 2.4e-257 mcpC NT chemotaxis protein
HICBILPI_02503 1.9e-189 splB 4.1.99.14 L Spore photoproduct lyase
HICBILPI_02504 6.1e-38 splA S Transcriptional regulator
HICBILPI_02505 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HICBILPI_02506 2.1e-39 ptsH G phosphocarrier protein HPr
HICBILPI_02507 0.0 ptsG 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
HICBILPI_02508 8.7e-156 glcT K antiterminator
HICBILPI_02509 7.3e-175 ykvZ 5.1.1.1 K Transcriptional regulator
HICBILPI_02511 3.4e-205 pepQ 3.4.13.9 E COG0006 Xaa-Pro aminopeptidase
HICBILPI_02512 0.0 cadA 3.6.3.3, 3.6.3.5 P COG2217 Cation transport ATPase
HICBILPI_02513 1.7e-87 stoA CO thiol-disulfide
HICBILPI_02514 4e-240 ykvU S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
HICBILPI_02515 9.1e-110 ykvT 3.5.1.28 M Cell Wall Hydrolase
HICBILPI_02516 3.9e-27
HICBILPI_02517 7.8e-25 ykvS S protein conserved in bacteria
HICBILPI_02518 3.8e-44 ykvR S Protein of unknown function (DUF3219)
HICBILPI_02519 7.7e-96 queF 1.7.1.13 S Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HICBILPI_02520 4.9e-139 queE 1.97.1.4, 4.3.99.3 H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
HICBILPI_02521 1.7e-78 queD 4.1.2.50, 4.2.3.12 H synthase
HICBILPI_02522 1.5e-126 queC 6.3.4.20 F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HICBILPI_02523 5e-183
HICBILPI_02524 1.3e-182 ykvI S membrane
HICBILPI_02525 0.0 clpE O Belongs to the ClpA ClpB family
HICBILPI_02526 3.3e-136 motA N flagellar motor
HICBILPI_02527 2.7e-127 motB N Flagellar motor protein
HICBILPI_02528 5.5e-77 ykvE K transcriptional
HICBILPI_02529 4.3e-275 kinD 2.7.13.3 T COG0642 Signal transduction histidine kinase
HICBILPI_02530 3.4e-10 S Spo0E like sporulation regulatory protein
HICBILPI_02531 7.1e-95 mtnD 1.13.11.53, 1.13.11.54 S Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HICBILPI_02532 1.5e-112 mtnB 3.1.3.87, 4.1.2.17, 4.2.1.109, 5.1.3.4 E Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P)
HICBILPI_02533 4.7e-128 mtnX 3.1.3.87, 4.2.1.109 E Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HICBILPI_02534 5.1e-226 mtnW 5.3.2.5 G Catalyzes the enolization of 2,3-diketo-5- methylthiopentyl-1-phosphate (DK-MTP-1-P) into 2-hydroxy-3-keto-5- methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P)
HICBILPI_02535 1.6e-227 mtnE 2.6.1.83 E Aminotransferase
HICBILPI_02536 7.7e-151 mtnU 3.5.1.3 S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
HICBILPI_02537 4.2e-225 mtnK 2.7.1.100 F Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HICBILPI_02538 1.7e-196 mtnA 5.3.1.23 E Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HICBILPI_02540 3.9e-87 ogt 2.1.1.63 L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HICBILPI_02541 0.0 kinE 2.7.13.3 T Histidine kinase
HICBILPI_02542 2.1e-188 ykrP G COG3594 Fucose 4-O-acetylase and related acetyltransferases
HICBILPI_02543 8.7e-23 ykzE
HICBILPI_02544 7.2e-113 ydfR S Protein of unknown function (DUF421)
HICBILPI_02545 4.8e-241 ktrB P COG0168 Trk-type K transport systems, membrane components
HICBILPI_02546 4.5e-155 htpX O Belongs to the peptidase M48B family
HICBILPI_02547 8.6e-125 ykrK S Domain of unknown function (DUF1836)
HICBILPI_02548 2.5e-26 sspD S small acid-soluble spore protein
HICBILPI_02549 1.5e-118 rsgI S Anti-sigma factor N-terminus
HICBILPI_02550 3.4e-127 sigI K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HICBILPI_02551 8.6e-134 ykoY P COG0861 Membrane protein TerC, possibly involved in tellurium resistance
HICBILPI_02552 8.6e-99 ykoX S membrane-associated protein
HICBILPI_02553 3.9e-151 ku L With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HICBILPI_02554 0.0 ligD 6.5.1.1 L ATP-dependent DNA ligase
HICBILPI_02555 6.4e-99 ykoP G polysaccharide deacetylase
HICBILPI_02556 1.1e-80 ykoM K transcriptional
HICBILPI_02557 3.1e-26 ykoL
HICBILPI_02558 1.9e-16
HICBILPI_02559 5.4e-53 tnrA K transcriptional
HICBILPI_02560 3.2e-237 mgtE P Acts as a magnesium transporter
HICBILPI_02562 7.4e-244 ydhD M Glycosyl hydrolase
HICBILPI_02563 1.3e-97 ykoE S ABC-type cobalt transport system, permease component
HICBILPI_02564 9.1e-303 P ABC transporter, ATP-binding protein
HICBILPI_02565 1.2e-132 ykoC P Cobalt transport protein
HICBILPI_02566 4.3e-147 T COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
HICBILPI_02567 5e-176 isp O Belongs to the peptidase S8 family
HICBILPI_02568 0.0 metE 2.1.1.14 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HICBILPI_02569 5.8e-121 yeiL T COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
HICBILPI_02570 2.6e-214 hcaT 1.5.1.2 EGP Major facilitator Superfamily
HICBILPI_02571 9.3e-123 M PFAM Collagen triple helix repeat (20 copies)
HICBILPI_02572 3.8e-215 M Glycosyl transferase family 2
HICBILPI_02574 1e-54 D Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HICBILPI_02575 4.2e-71 ohrB O Organic hydroperoxide resistance protein
HICBILPI_02576 1.1e-72 ohrR K COG1846 Transcriptional regulators
HICBILPI_02577 4.1e-69 ohrA O Organic hydroperoxide resistance protein
HICBILPI_02578 7.6e-225 proA 1.2.1.41, 1.2.1.81 E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HICBILPI_02579 1.1e-203 proB 2.7.2.11 E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HICBILPI_02580 3e-170 purU 2.7.7.72, 3.5.1.10 F Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)
HICBILPI_02581 2.9e-48 ykkD P Multidrug resistance protein
HICBILPI_02582 1.3e-51 ykkC P Multidrug resistance protein
HICBILPI_02583 1.1e-98 ykkB 2.3.1.128 J COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
HICBILPI_02584 8.4e-93 ykhA 3.1.2.20 I Acyl-CoA hydrolase
HICBILPI_02585 5.5e-158 ykgA E Amidinotransferase
HICBILPI_02586 1.5e-205 pgl 3.1.1.31 G 6-phosphogluconolactonase
HICBILPI_02587 1.6e-182 ykfD E Belongs to the ABC transporter superfamily
HICBILPI_02588 8.6e-170 ykfC 3.4.14.13 M COG0791 Cell wall-associated hydrolases (invasion-associated proteins)
HICBILPI_02589 5.9e-197 ykfB 5.1.1.20 M Belongs to the mandelate racemase muconate lactonizing enzyme family
HICBILPI_02590 3.7e-176 ykfA 3.4.17.13 V proteins, homologs of microcin C7 resistance protein MccF
HICBILPI_02591 0.0 dppE E ABC transporter substrate-binding protein
HICBILPI_02592 1.6e-188 dppD P Belongs to the ABC transporter superfamily
HICBILPI_02593 5e-176 dppC EP COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
HICBILPI_02594 5.4e-159 dppB P COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
HICBILPI_02595 9.3e-155 dppA E D-aminopeptidase
HICBILPI_02596 3.3e-278 yubD P Major Facilitator Superfamily
HICBILPI_02597 1e-203 htrA 3.4.21.107 O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HICBILPI_02598 1.5e-16 ykcC GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
HICBILPI_02599 4.2e-178 ykcC GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
HICBILPI_02600 4.7e-299 ykcB M COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HICBILPI_02601 8.2e-179 mhqA E COG0346 Lactoylglutathione lyase and related lyases
HICBILPI_02602 1.1e-242 steT E amino acid
HICBILPI_02603 6.9e-110 ykaA P COG1392 Phosphate transport regulator (distant homolog of PhoU)
HICBILPI_02604 5.8e-175 pit P phosphate transporter
HICBILPI_02605 5.9e-132 spoIISA S Toxin SpoIISA, type II toxin-antitoxin system
HICBILPI_02606 8.7e-23 spoIISB S Stage II sporulation protein SB
HICBILPI_02607 1.6e-168 xlyA 3.5.1.28 M n-acetylmuramoyl-L-alanine amidase
HICBILPI_02608 1.3e-38 xhlB S SPP1 phage holin
HICBILPI_02609 9.6e-37 xhlA S Haemolysin XhlA
HICBILPI_02610 8.1e-137 xepA
HICBILPI_02611 1.6e-28 xkdX
HICBILPI_02613 6.4e-91
HICBILPI_02614 1.2e-26
HICBILPI_02615 8.5e-86 xkdU S Uncharacterised protein conserved in bacteria (DUF2313)
HICBILPI_02616 8.3e-92 xkdT S Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
HICBILPI_02617 7.6e-50 xkdT S Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
HICBILPI_02618 4.2e-58 xkdS S Protein of unknown function (DUF2634)
HICBILPI_02619 7.2e-32 xkdR S Protein of unknown function (DUF2577)
HICBILPI_02620 9.4e-162 xkdQ 3.2.1.96 G NLP P60 protein
HICBILPI_02621 6.6e-111 xkdP S Lysin motif
HICBILPI_02622 3.1e-143 xkdO L Transglycosylase SLT domain
HICBILPI_02623 1.8e-68 xkdO L Transglycosylase SLT domain
HICBILPI_02624 3.4e-19
HICBILPI_02625 1.7e-73 S Phage XkdN-like tail assembly chaperone protein, TAC
HICBILPI_02626 2e-74 xkdM S Phage tail tube protein
HICBILPI_02627 7.7e-226 xkdK S Phage tail sheath C-terminal domain
HICBILPI_02628 8.2e-15
HICBILPI_02629 3.2e-56 xkdJ
HICBILPI_02630 4.1e-60 xkdI S Bacteriophage HK97-gp10, putative tail-component
HICBILPI_02631 5.5e-43 yqbH S Domain of unknown function (DUF3599)
HICBILPI_02632 3.3e-46 yqbG S Protein of unknown function (DUF3199)
HICBILPI_02633 4.6e-158 xkdG S Phage capsid family
HICBILPI_02634 9.8e-91 xkdF 2.1.1.72 L Putative phage serine protease XkdF
HICBILPI_02635 5.1e-241 yqbA S portal protein
HICBILPI_02636 3.6e-209 xtmB S phage terminase, large subunit
HICBILPI_02637 8.9e-110 xtmA L phage terminase small subunit
HICBILPI_02638 3.1e-84 xpf K COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog
HICBILPI_02639 2e-10 yqaO S Phage-like element PBSX protein XtrA
HICBILPI_02642 8.8e-150 xkdC L Bacterial dnaA protein
HICBILPI_02644 1.1e-56 xre K Helix-turn-helix XRE-family like proteins
HICBILPI_02645 2.9e-110 xkdA E IrrE N-terminal-like domain
HICBILPI_02647 3.9e-110 yjqB S phage-related replication protein
HICBILPI_02648 8e-61 yjqA S Bacterial PH domain
HICBILPI_02649 2.2e-168 xlyA 3.5.1.28 M N-acetylmuramoyl-L-alanine amidase
HICBILPI_02651 4.9e-215 S response regulator aspartate phosphatase
HICBILPI_02652 3.1e-78 yjoA S DinB family
HICBILPI_02653 1.9e-130 MA20_18170 S membrane transporter protein
HICBILPI_02654 3.4e-204 salB V Domain of unknown function (DUF4135)
HICBILPI_02656 1.9e-25 lanT 3.6.3.27 V Peptidase C39 family
HICBILPI_02657 7.4e-184 lanT 3.6.3.27 V Peptidase C39 family
HICBILPI_02658 5.1e-67 lcnDR2 V Lanthionine synthetase C-like protein
HICBILPI_02659 7.9e-116 lcnDR2 V Lanthionine synthetase C-like protein
HICBILPI_02660 2.6e-97 lcnDR2 V Lanthionine synthetase C-like protein
HICBILPI_02662 5.4e-60 K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HICBILPI_02663 2.2e-46 narQ 2.7.13.3 T Histidine kinase
HICBILPI_02665 1.4e-64 S ABC-2 family transporter protein
HICBILPI_02666 8.5e-104 V ABC transporter, ATP-binding protein
HICBILPI_02667 1.4e-131 T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain
HICBILPI_02668 4e-87 T Transcriptional regulatory protein, C terminal
HICBILPI_02669 5.3e-285 uxaA 4.2.1.7, 4.4.1.24 G Altronate
HICBILPI_02670 7e-181 exuR K transcriptional
HICBILPI_02671 2.5e-253 yjmB G symporter YjmB
HICBILPI_02672 3.8e-273 uxaC 5.3.1.12 G glucuronate isomerase
HICBILPI_02673 2.9e-218 yjlD 1.6.99.3 C NADH dehydrogenase
HICBILPI_02674 7e-66 yjlC S Protein of unknown function (DUF1641)
HICBILPI_02675 1.8e-89 yjlB S Cupin domain
HICBILPI_02676 4.4e-175 yjlA EG Putative multidrug resistance efflux transporter
HICBILPI_02677 1e-128 pstB 3.6.3.27 P Belongs to the ABC transporter superfamily
HICBILPI_02678 2.1e-124 ybbM S transport system, permease component
HICBILPI_02679 1.2e-141 hemD 2.1.1.107, 4.2.1.75 H Uroporphyrinogen-III synthase
HICBILPI_02680 6.8e-29
HICBILPI_02681 1.1e-217 oleD GT1 CG COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase
HICBILPI_02682 4.4e-225 yjiB 1.14.13.154, 1.14.15.8 C Cytochrome P450
HICBILPI_02683 4.3e-92 yjgD S Protein of unknown function (DUF1641)
HICBILPI_02684 0.0 yjgC 1.17.1.10, 1.17.1.9 C formate dehydrogenase, alpha subunit
HICBILPI_02685 5.9e-100 yjgB S Domain of unknown function (DUF4309)
HICBILPI_02686 2.6e-65 T PhoQ Sensor
HICBILPI_02687 1.3e-21 yjfB S Putative motility protein
HICBILPI_02689 8.1e-106 yhiD S MgtC SapB transporter
HICBILPI_02691 3.7e-144 N Kelch motif
HICBILPI_02692 1e-122 5.4.2.6 S Haloacid dehalogenase-like hydrolase
HICBILPI_02693 1e-129 lacR K COG1349 Transcriptional regulators of sugar metabolism
HICBILPI_02694 6.9e-283 lacG 3.2.1.85 G Belongs to the glycosyl hydrolase 1 family
HICBILPI_02695 9.1e-50 lacF 2.7.1.207 G phosphotransferase system
HICBILPI_02696 1.1e-306 lacE 2.7.1.196, 2.7.1.205, 2.7.1.207 G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HICBILPI_02697 7.4e-214 galK 2.7.1.6 G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HICBILPI_02698 2.1e-185 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
HICBILPI_02699 7.1e-286 galT 2.7.7.12 G UDP-glucose--hexose-1-phosphate uridylyltransferase
HICBILPI_02700 5e-220 ganA 3.2.1.89 G arabinogalactan
HICBILPI_02701 5.1e-81 napB K helix_turn_helix multiple antibiotic resistance protein
HICBILPI_02702 1.7e-249 yfjF EGP Belongs to the major facilitator superfamily
HICBILPI_02703 4.2e-46 yjcS S Antibiotic biosynthesis monooxygenase
HICBILPI_02704 1.5e-161 bla 3.5.2.6 V beta-lactamase
HICBILPI_02705 1.5e-57 E Glyoxalase-like domain
HICBILPI_02707 1.1e-256 yobL S Bacterial EndoU nuclease
HICBILPI_02708 2e-22
HICBILPI_02710 1.1e-217 metC 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
HICBILPI_02711 5.6e-211 metB 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
HICBILPI_02712 3.6e-126 yjcH P COG2382 Enterochelin esterase and related enzymes
HICBILPI_02713 1.1e-92 yjcG J Belongs to the 2H phosphoesterase superfamily. YjcG family
HICBILPI_02714 2.3e-72 yjcF S COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HICBILPI_02716 2.7e-35 K SpoVT / AbrB like domain
HICBILPI_02717 6.4e-131 nodI V AAA domain, putative AbiEii toxin, Type IV TA system
HICBILPI_02718 5.7e-124 S ABC-2 type transporter
HICBILPI_02719 1.4e-141 blm 3.5.2.6 S Belongs to the metallo-beta-lactamase superfamily. Class-B beta-lactamase family
HICBILPI_02720 1.3e-35
HICBILPI_02721 0.0 yjcD 3.6.4.12 L DNA helicase
HICBILPI_02722 3.8e-38 spoVIF S Stage VI sporulation protein F
HICBILPI_02726 5.6e-56 yjcA S Protein of unknown function (DUF1360)
HICBILPI_02727 1.4e-52 cotV S Spore Coat Protein X and V domain
HICBILPI_02728 6.8e-21 cotW
HICBILPI_02729 5.1e-71 cotX S Spore Coat Protein X and V domain
HICBILPI_02730 4.6e-93 cotY S Spore coat protein Z
HICBILPI_02731 6.7e-83 cotZ S Spore coat protein
HICBILPI_02732 1.5e-88 yjbX S Spore coat protein
HICBILPI_02733 4e-139 fabI 1.3.1.10, 1.3.1.9 I Enoyl- acyl-carrier-protein reductase NADH
HICBILPI_02734 6.4e-148 thiD 2.5.1.3, 2.7.1.35, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Phosphomethylpyrimidine kinase
HICBILPI_02735 1.1e-186 thiF 2.7.7.73, 2.7.7.80 H COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
HICBILPI_02736 7.6e-135 thiG 2.8.1.10 H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S
HICBILPI_02737 6.7e-30 thiS H Thiamine biosynthesis
HICBILPI_02738 2.8e-210 thiO 1.4.3.19 E Glycine oxidase
HICBILPI_02739 3.5e-106 tenI 2.5.1.3, 5.3.99.10 H Transcriptional regulator TenI
HICBILPI_02740 3.7e-136 tenA 3.5.99.2 K Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HICBILPI_02741 0.0 yjbQ P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
HICBILPI_02742 1.2e-143 prpE 3.1.3.16, 3.6.1.41 T Asymmetrically hydrolyzes Ap4p to yield AMP and ATP
HICBILPI_02743 4.1e-164 yjbO 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
HICBILPI_02744 2.1e-151 nadK 2.7.1.23 G Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HICBILPI_02745 1.1e-107 yjbM 2.7.6.5 S GTP pyrophosphokinase
HICBILPI_02746 8.6e-60 yjbL S Belongs to the UPF0738 family
HICBILPI_02747 1.5e-95 yjbK S protein conserved in bacteria
HICBILPI_02748 1.2e-115 yjbJ M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)
HICBILPI_02749 4.8e-72 yjbI S Bacterial-like globin
HICBILPI_02750 6.6e-170 yjbH Q dithiol-disulfide isomerase involved in polyketide biosynthesis
HICBILPI_02751 5.8e-19
HICBILPI_02752 0.0 pepF E oligoendopeptidase F
HICBILPI_02753 2.3e-215 yjbF S Competence protein
HICBILPI_02754 2e-116 mecA NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC
HICBILPI_02755 4.7e-109 yjbE P Integral membrane protein TerC family
HICBILPI_02756 1.6e-67 spxA 1.20.4.1 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
HICBILPI_02757 1.3e-102 yjbC K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HICBILPI_02758 9.8e-230 S Putative glycosyl hydrolase domain
HICBILPI_02759 2.3e-170 oppF E Belongs to the ABC transporter superfamily
HICBILPI_02760 2.7e-202 oppD P Belongs to the ABC transporter superfamily
HICBILPI_02761 1.7e-165 oppC EP COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
HICBILPI_02762 9.2e-167 oppB P COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
HICBILPI_02763 0.0 oppA E ABC transporter substrate-binding protein
HICBILPI_02764 5.2e-184 trpS 6.1.1.2 J Tryptophanyl-tRNA synthetase
HICBILPI_02765 4.7e-145 yjbA S Belongs to the UPF0736 family
HICBILPI_02766 1.8e-162 appC EP COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
HICBILPI_02767 2.2e-171 oppB P COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
HICBILPI_02768 0.0 appA E COG0747 ABC-type dipeptide transport system, periplasmic component
HICBILPI_02769 5.9e-188 appF E Belongs to the ABC transporter superfamily
HICBILPI_02770 4.8e-182 appD P Belongs to the ABC transporter superfamily
HICBILPI_02771 5.6e-149 yjaZ O Zn-dependent protease
HICBILPI_02772 1.2e-233 fabF 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
HICBILPI_02773 1.5e-172 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HICBILPI_02774 1e-31 yjzB
HICBILPI_02775 1.1e-26 comZ S ComZ
HICBILPI_02776 2.7e-165 med S Transcriptional activator protein med
HICBILPI_02777 1.7e-102 yjaV
HICBILPI_02778 8.4e-139 yjaU I carboxylic ester hydrolase activity
HICBILPI_02779 3.3e-23 yjzD S Protein of unknown function (DUF2929)
HICBILPI_02780 1.2e-27 yjzC S YjzC-like protein
HICBILPI_02781 8.7e-176 argF 2.1.3.3 E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HICBILPI_02782 0.0 carB 6.3.5.5 EF Carbamoyl-phosphate synthetase ammonia chain
HICBILPI_02783 6.5e-201 carA 6.3.5.5 F Carbamoyl-phosphate synthetase glutamine chain
HICBILPI_02784 2.5e-141 argD 2.6.1.11, 2.6.1.17 E acetylornithine aminotransferase
HICBILPI_02785 1.9e-40 argD 2.6.1.11, 2.6.1.17 E acetylornithine aminotransferase
HICBILPI_02786 1.1e-136 argB 2.7.2.8 F Belongs to the acetylglutamate kinase family. ArgB subfamily
HICBILPI_02787 1.5e-225 argJ 2.3.1.1, 2.3.1.35, 2.7.2.8 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HICBILPI_02788 1.5e-197 argC 1.2.1.38 E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HICBILPI_02789 1.2e-89 norB G Major Facilitator Superfamily
HICBILPI_02790 1.5e-272 yitY C D-arabinono-1,4-lactone oxidase
HICBILPI_02791 4.6e-73 fosB 2.5.1.18 H Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor
HICBILPI_02792 4.7e-51 yitW S metal-sulfur cluster biosynthetic enzyme
HICBILPI_02793 9e-144 yjfP S COG1073 Hydrolases of the alpha beta superfamily
HICBILPI_02794 5.1e-153 yitU 3.1.3.104 S Sucrose-6F-phosphate phosphohydrolase
HICBILPI_02795 3.5e-07
HICBILPI_02796 4.4e-26 S Protein of unknown function (DUF3813)
HICBILPI_02797 1.2e-79 ipi S Intracellular proteinase inhibitor
HICBILPI_02798 2.5e-147 yitT S Uncharacterized protein conserved in bacteria (DUF2179)
HICBILPI_02799 4.9e-99 yitS S protein conserved in bacteria
HICBILPI_02800 3e-47 yitS S protein conserved in bacteria
HICBILPI_02802 7.4e-110 yvaQ NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).
HICBILPI_02803 1.2e-158 yufN S ABC transporter substrate-binding protein PnrA-like
HICBILPI_02805 7.6e-160 cvfB S protein conserved in bacteria
HICBILPI_02806 6.6e-55 yajQ S Belongs to the UPF0234 family
HICBILPI_02807 0.0 yitJ 1.5.1.20, 2.1.1.10, 2.1.1.13 E Catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine
HICBILPI_02808 1.1e-80 yjcF S Acetyltransferase (GNAT) domain
HICBILPI_02809 1.6e-69 mcbG S Pentapeptide repeats (9 copies)
HICBILPI_02810 3.1e-81 yisT S DinB family
HICBILPI_02811 5.8e-154 yisS 1.1.1.370 S Oxidoreductase family, C-terminal alpha/beta domain
HICBILPI_02812 9.2e-144 purR K helix_turn _helix lactose operon repressor
HICBILPI_02813 2.3e-159 yisR K Transcriptional regulator
HICBILPI_02814 4.3e-245 yisQ V Mate efflux family protein
HICBILPI_02815 3.6e-129 crtB 2.5.1.21, 2.5.1.32, 2.5.1.99 I phytoene
HICBILPI_02816 0.0 asnO 6.3.5.4 E Asparagine synthase
HICBILPI_02817 3.4e-97 yisN S Protein of unknown function (DUF2777)
HICBILPI_02818 3.2e-59 yisL S UPF0344 protein
HICBILPI_02819 7.8e-171 yisK Q COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)
HICBILPI_02820 4.8e-07 yisI S Spo0E like sporulation regulatory protein
HICBILPI_02821 8.4e-34 gerPA S Spore germination protein
HICBILPI_02822 1.8e-34 gerPB S cell differentiation
HICBILPI_02823 1.4e-62 gerPC S Spore germination protein
HICBILPI_02824 3.1e-23 gerPD S Spore germination protein
HICBILPI_02825 1.1e-63 gerPE S Spore germination protein GerPE
HICBILPI_02826 5.9e-32 gerPF S Spore germination protein gerPA/gerPF
HICBILPI_02827 5e-50 yisB V COG1403 Restriction endonuclease
HICBILPI_02828 0.0 sbcC L COG0419 ATPase involved in DNA repair
HICBILPI_02829 9.4e-94 sbcC L COG0419 ATPase involved in DNA repair
HICBILPI_02830 1.1e-222 sbcD L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
HICBILPI_02831 0.0 addA 3.6.4.12 L ATP-dependent helicase nuclease subunit A
HICBILPI_02832 0.0 addB 3.1.21.3, 3.6.4.12 L ATP-dependent helicase deoxyribonuclease subunit B
HICBILPI_02833 2.5e-119 ydfS S Protein of unknown function (DUF421)
HICBILPI_02834 6.3e-93 yhjR S Rubrerythrin
HICBILPI_02835 1.1e-107 K QacR-like protein, C-terminal region
HICBILPI_02836 3e-202 blt EGP Major facilitator Superfamily
HICBILPI_02837 2.8e-176 abrB S membrane
HICBILPI_02838 8.4e-93 yhjH K helix_turn_helix multiple antibiotic resistance protein
HICBILPI_02839 2.1e-269 yhjG CH FAD binding domain
HICBILPI_02841 9.2e-92 sipV 3.4.21.89 U Belongs to the peptidase S26 family
HICBILPI_02842 7.7e-109 yhjE S SNARE associated Golgi protein
HICBILPI_02843 1.7e-60 yhjD
HICBILPI_02844 3.1e-27 yhjC S Protein of unknown function (DUF3311)
HICBILPI_02845 5e-268 yhjB E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HICBILPI_02846 3.3e-47 S Belongs to the UPF0145 family
HICBILPI_02847 1.6e-42 yhjA S Excalibur calcium-binding domain
HICBILPI_02848 1.9e-124 yrpD S Domain of unknown function, YrpD
HICBILPI_02849 4.2e-62 frataxin S Domain of unknown function (DU1801)
HICBILPI_02850 4.7e-66 frataxin S Domain of unknown function (DU1801)
HICBILPI_02851 1.9e-109 comK K Competence transcription factor
HICBILPI_02852 5.4e-31 yhzC S IDEAL
HICBILPI_02853 6.5e-159 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HICBILPI_02854 3.5e-296 yhfW CE COG0665 Glycine D-amino acid oxidases (deaminating)
HICBILPI_02855 3.1e-197 hemAT NT chemotaxis protein
HICBILPI_02856 3.5e-89 bioY S BioY family
HICBILPI_02857 1.4e-278 yhfT 6.2.1.3 IQ AMP-binding enzyme C-terminal domain
HICBILPI_02858 4.3e-200 vraB 2.3.1.9 I Belongs to the thiolase family
HICBILPI_02859 4.4e-103 yhfR 3.1.3.73 G Belongs to the phosphoglycerate mutase family
HICBILPI_02860 5.8e-86 yhfQ P COG4594 ABC-type Fe3 -citrate transport system, periplasmic component
HICBILPI_02861 1.1e-48 yhfQ P COG4594 ABC-type Fe3 -citrate transport system, periplasmic component
HICBILPI_02862 2.2e-202 aprE 3.4.21.62 O Belongs to the peptidase S8 family
HICBILPI_02863 3.6e-235 yhfN 3.4.24.84 O Peptidase M48
HICBILPI_02864 1.5e-62 yhfM
HICBILPI_02865 1.1e-86 fadD 6.2.1.3 IQ AMP-binding enzyme C-terminal domain
HICBILPI_02866 1.4e-161 fadD 6.2.1.3 IQ AMP-binding enzyme C-terminal domain
HICBILPI_02867 2.7e-109 yhfK GM NmrA-like family
HICBILPI_02868 5.9e-188 lplJ 6.3.1.20 H Lipoate-protein ligase
HICBILPI_02869 2.2e-139 yhfI S COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III
HICBILPI_02870 7.9e-11 yhfH S YhfH-like protein
HICBILPI_02871 7.4e-223 gltP C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
HICBILPI_02872 8.6e-198 yhfE 3.2.1.4 GH5,GH9 G peptidase M42
HICBILPI_02874 3.3e-183 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HICBILPI_02875 7.2e-245 yhgE S YhgE Pip N-terminal domain protein
HICBILPI_02876 3.2e-101 yhgD K Transcriptional regulator
HICBILPI_02877 1.6e-274 hemG 1.14.19.9, 1.3.3.15, 1.3.3.4 H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HICBILPI_02878 9.5e-180 hemH 4.99.1.1, 4.99.1.9 H Catalyzes the ferrous insertion into protoporphyrin IX
HICBILPI_02879 9.5e-203 hemE 4.1.1.37 H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HICBILPI_02880 0.0 pbpF 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
HICBILPI_02881 2.4e-89 traP 1.14.99.57, 6.2.1.3 S enzyme involved in biosynthesis of extracellular polysaccharides
HICBILPI_02882 1.1e-108 yhfA C membrane
HICBILPI_02883 8.9e-125 yhfA C membrane
HICBILPI_02884 2e-222 yhaA 3.5.1.47 E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
HICBILPI_02885 4e-122 ecsC S EcsC protein family
HICBILPI_02886 4.2e-220 ecsB U ABC transporter
HICBILPI_02887 1.1e-135 ecsA V transporter (ATP-binding protein)
HICBILPI_02888 4e-80 hit FG COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
HICBILPI_02889 2.3e-201 serC 2.6.1.52 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HICBILPI_02890 2.1e-57 trpP S Tryptophan transporter TrpP
HICBILPI_02891 2e-17
HICBILPI_02892 6.2e-39 yhaH S YtxH-like protein
HICBILPI_02893 8.6e-113 hpr K Negative regulator of protease production and sporulation
HICBILPI_02894 9.9e-55 yhaI S Protein of unknown function (DUF1878)
HICBILPI_02895 7e-95 yhaK S Putative zincin peptidase
HICBILPI_02896 9.1e-121 prsA 5.2.1.8 M plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins
HICBILPI_02897 1.8e-31 yhaL S Sporulation protein YhaL
HICBILPI_02898 2.6e-177 yhaM L Shows a 3'-5' exoribonuclease activity
HICBILPI_02899 0.0 yhaN L AAA domain
HICBILPI_02900 4.7e-235 yhaO L DNA repair exonuclease
HICBILPI_02901 1.2e-206 yhaP CP COG1668 ABC-type Na efflux pump, permease component
HICBILPI_02902 4.4e-166 yhaQ S ABC transporter, ATP-binding protein
HICBILPI_02903 1.1e-13 S YhzD-like protein
HICBILPI_02904 6.6e-20 yhaR 5.3.3.18 I enoyl-CoA hydratase
HICBILPI_02905 4.4e-60 yhaR 5.3.3.18 I enoyl-CoA hydratase
HICBILPI_02906 2.5e-21 yhaR 5.3.3.18 I enoyl-CoA hydratase
HICBILPI_02907 3.3e-86 yhaT P regulatory, ligand-binding protein related to C-terminal domains of K channels
HICBILPI_02908 8.2e-208 yhaU P COG0475 Kef-type K transport systems, membrane components
HICBILPI_02909 7.8e-249 iucD 1.14.13.59 Q L-lysine 6-monooxygenase (NADPH-requiring)
HICBILPI_02910 2.7e-293 hemZ H coproporphyrinogen III oxidase
HICBILPI_02911 4.7e-157 yhaX S haloacid dehalogenase-like hydrolase
HICBILPI_02912 5.9e-200 yhaZ L DNA alkylation repair enzyme
HICBILPI_02913 4.4e-53 yheA S Belongs to the UPF0342 family
HICBILPI_02914 8.1e-88 yheB S Belongs to the UPF0754 family
HICBILPI_02915 1.2e-104 yheB S Belongs to the UPF0754 family
HICBILPI_02916 1.7e-212 yheC HJ YheC/D like ATP-grasp
HICBILPI_02917 1.5e-258 gshB 6.3.2.2, 6.3.2.3 HJ YheC/D like ATP-grasp
HICBILPI_02918 2.2e-36 yheE S Family of unknown function (DUF5342)
HICBILPI_02919 1.3e-28 sspB S spore protein
HICBILPI_02921 1.6e-111 yheG GM NAD(P)H-binding
HICBILPI_02922 0.0 yheH V COG1132 ABC-type multidrug transport system, ATPase and permease components
HICBILPI_02923 0.0 yheI V COG1132 ABC-type multidrug transport system, ATPase and permease components
HICBILPI_02925 3.1e-84 T universal stress protein
HICBILPI_02926 4e-93 ymcC S Membrane
HICBILPI_02927 3e-87 pksA K Transcriptional regulator
HICBILPI_02928 9e-153 dat 2.6.1.21 E Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha- keto acid in the first half-reaction
HICBILPI_02929 1.1e-155 yheN G deacetylase
HICBILPI_02930 3.8e-139 cobB K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form
HICBILPI_02931 3.5e-205 yhdY M Mechanosensitive ion channel
HICBILPI_02933 7.2e-127 yhdW 3.1.4.46 C glycerophosphoryl diester phosphodiesterase
HICBILPI_02934 1.9e-57 crcB D Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HICBILPI_02935 3.6e-50 crcB D Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HICBILPI_02936 6e-255 corC1 P COG1253 Hemolysins and related proteins containing CBS domains
HICBILPI_02937 1.6e-227 pksF 2.3.1.179, 2.3.1.41 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
HICBILPI_02938 1.9e-225 yhdR 2.6.1.1 E Aminotransferase
HICBILPI_02939 2.8e-70 cueR K transcriptional
HICBILPI_02940 4.3e-242 corC1 S COG1253 Hemolysins and related proteins containing CBS domains
HICBILPI_02941 4.8e-108 plsC 2.3.1.51 I Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family
HICBILPI_02942 4.2e-86 sigM K Belongs to the sigma-70 factor family. ECF subfamily
HICBILPI_02943 1.3e-201 yhdL S Sigma factor regulator N-terminal
HICBILPI_02944 8.1e-45 yhdK S Sigma-M inhibitor protein
HICBILPI_02945 2.9e-198 yhdH S Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
HICBILPI_02946 1.2e-250 yhdG E amino acid
HICBILPI_02947 8.6e-159 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HICBILPI_02948 1.6e-205 citA 2.3.3.1 C Belongs to the citrate synthase family
HICBILPI_02949 1.3e-162 citR K Transcriptional regulator
HICBILPI_02950 3.7e-127 lytE 3.5.1.28 CBM50 M COG1388 FOG LysM repeat
HICBILPI_02951 1.3e-257 phoB 3.1.3.1 P Belongs to the alkaline phosphatase family
HICBILPI_02952 1.8e-270 ycgB S Stage V sporulation protein R
HICBILPI_02953 3.1e-244 ygxB M Conserved TM helix
HICBILPI_02954 1.6e-73 nsrR K Transcriptional regulator
HICBILPI_02955 5.4e-214 sle1 3.5.1.28 CBM50 M COG1388 FOG LysM repeat
HICBILPI_02956 1.1e-53 yhdC S Protein of unknown function (DUF3889)
HICBILPI_02957 2.5e-39 yhdB S YhdB-like protein
HICBILPI_02958 4.3e-89 azr 1.7.1.6 S NADPH-dependent FMN reductase
HICBILPI_02959 1.6e-36 yhcZ K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HICBILPI_02960 8.5e-70 yhcY 2.7.13.3 T Histidine kinase
HICBILPI_02961 0.0 pmmB 5.4.2.2, 5.4.2.8 G Phosphoglucomutase
HICBILPI_02962 0.0 glpD 1.1.5.3 C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HICBILPI_02963 1.6e-293 glpK 2.7.1.30 C Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HICBILPI_02964 7.7e-149 glpF G Belongs to the MIP aquaporin (TC 1.A.8) family
HICBILPI_02965 5.8e-103 glpP K Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HICBILPI_02966 2.4e-261 yhxA E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HICBILPI_02967 5e-303 yhcX 3.5.1.3 K Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
HICBILPI_02968 1.1e-124 yhcW 5.4.2.6 S hydrolase
HICBILPI_02969 9.9e-68 yhcV S COG0517 FOG CBS domain
HICBILPI_02970 1.3e-69 yhcU S Family of unknown function (DUF5365)
HICBILPI_02971 4e-167 rluA 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
HICBILPI_02972 1.7e-105 yhcS 3.4.22.70 M COG3764 Sortase (surface protein transpeptidase)
HICBILPI_02973 0.0 yhcR 3.1.3.5 F Belongs to the 5'-nucleotidase family
HICBILPI_02974 8.4e-114 yhcQ M Spore coat protein
HICBILPI_02975 1.4e-159 yhcP
HICBILPI_02976 5.7e-84 yhcN S Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
HICBILPI_02977 6.5e-54 yhcM
HICBILPI_02978 1.5e-229 ydjN U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
HICBILPI_02979 2.5e-184 yhcK 2.7.7.65 T COG2199 FOG GGDEF domain
HICBILPI_02980 1.7e-143 metQ M Belongs to the nlpA lipoprotein family
HICBILPI_02981 3.9e-30 cspB K 'Cold-shock' DNA-binding domain
HICBILPI_02982 8.2e-163 yhcI S COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
HICBILPI_02983 3.4e-166 yhcH V ABC transporter, ATP-binding protein
HICBILPI_02984 1.3e-123 yhcG V ABC transporter, ATP-binding protein
HICBILPI_02985 2.8e-61 yhcF K Transcriptional regulator
HICBILPI_02986 8.1e-52
HICBILPI_02987 3.8e-55 yhcC
HICBILPI_02988 4.7e-99 yhcB 1.6.5.2 S NADPH-dependent FMN reductase
HICBILPI_02989 8.4e-285 yhcA EGP Major facilitator Superfamily
HICBILPI_02990 8.1e-98 yhbJ V COG1566 Multidrug resistance efflux pump
HICBILPI_02991 4.6e-74 yhbI K DNA-binding transcription factor activity
HICBILPI_02992 3.9e-215 yhbH S Belongs to the UPF0229 family
HICBILPI_02993 0.0 prkA T Ser protein kinase
HICBILPI_02995 1e-61 yhbF M COG1664 Integral membrane protein CcmA involved in cell shape determination
HICBILPI_02996 8.9e-61 yhbE M COG1664 Integral membrane protein CcmA involved in cell shape determination
HICBILPI_02997 3e-108 yhbD K Protein of unknown function (DUF4004)
HICBILPI_02998 2e-85 trmL 2.1.1.207 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
HICBILPI_02999 1.4e-173 yhbB S Putative amidase domain
HICBILPI_03000 1.2e-131 queG 1.17.99.6 C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HICBILPI_03001 1.2e-50 queG 1.17.99.6 C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HICBILPI_03002 9.4e-107 yhzB S B3/4 domain
HICBILPI_03004 4.8e-23 K Transcriptional regulator
HICBILPI_03005 8.6e-81 ygaO
HICBILPI_03006 1.6e-42 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HICBILPI_03007 2.5e-214 ssuD 1.14.14.5 C Catalyzes the desulfonation of aliphatic sulfonates
HICBILPI_03008 7e-142 ssuC P ABC transporter (permease)
HICBILPI_03009 4.4e-167 ssuA M Sulfonate ABC transporter
HICBILPI_03010 1.6e-140 ssuB P COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component
HICBILPI_03011 1.7e-47 S Amidohydrolase
HICBILPI_03012 1.1e-92 S Amidohydrolase
HICBILPI_03013 2.1e-290 katA 1.11.1.6 P serves to protect cells from the toxic effects of hydrogen peroxide
HICBILPI_03014 4e-133 oppF3 E Belongs to the ABC transporter superfamily
HICBILPI_03015 1.3e-134 oppD3 P Belongs to the ABC transporter superfamily
HICBILPI_03016 1.7e-125 appC EP COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
HICBILPI_03017 5.4e-138 appB P Binding-protein-dependent transport system inner membrane component
HICBILPI_03018 2.8e-230 oppA5 E PFAM extracellular solute-binding protein family 5
HICBILPI_03020 1.9e-72 ygaK C Berberine and berberine like
HICBILPI_03021 5.9e-171 ygaK C Berberine and berberine like
HICBILPI_03022 0.0 thiC 4.1.99.17 H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HICBILPI_03023 2.4e-130 pepE 3.4.11.2, 3.4.13.21 E Belongs to the peptidase S51 family
HICBILPI_03027 1.6e-08
HICBILPI_03035 7.8e-08
HICBILPI_03040 3.4e-39 S COG NOG14552 non supervised orthologous group
HICBILPI_03041 1.1e-164 ygxA S Nucleotidyltransferase-like
HICBILPI_03042 1.5e-56 ygzB S UPF0295 protein
HICBILPI_03043 1.8e-80 perR P Belongs to the Fur family
HICBILPI_03044 3.1e-86 bcp 1.11.1.15 O Peroxiredoxin
HICBILPI_03045 6.2e-246 gsaB 5.4.3.8 H Glutamate-1-semialdehyde aminotransferase
HICBILPI_03046 2.7e-178 ygaE S Membrane
HICBILPI_03047 9.5e-240 ygaD V ABC transporter
HICBILPI_03048 1.3e-46 ygaD V ABC transporter
HICBILPI_03049 2.2e-104 ygaC J Belongs to the UPF0374 family
HICBILPI_03050 1.5e-37 ygaB S YgaB-like protein
HICBILPI_03052 5.8e-135 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HICBILPI_03053 3.1e-36 yfhS
HICBILPI_03054 4.8e-207 mutY L A G-specific
HICBILPI_03055 1e-184 yfhP S membrane-bound metal-dependent
HICBILPI_03056 0.0 yfhO S Bacterial membrane protein YfhO
HICBILPI_03057 4.6e-185 csbB GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
HICBILPI_03058 9.1e-169 yfhM S Alpha/beta hydrolase family
HICBILPI_03059 9.7e-34 yfhL S SdpI/YhfL protein family
HICBILPI_03060 8.5e-93 batE T Bacterial SH3 domain homologues
HICBILPI_03061 2.2e-44 yfhJ S WVELL protein
HICBILPI_03062 2e-166 mpr 3.4.21.19 M Belongs to the peptidase S1B family
HICBILPI_03064 1.1e-204 yfhI EGP Major facilitator Superfamily
HICBILPI_03065 2.5e-52 yfhH S Protein of unknown function (DUF1811)
HICBILPI_03066 6.7e-142 recX 2.4.1.337 GT4 S Modulates RecA activity
HICBILPI_03067 1.7e-152 yfhF S nucleoside-diphosphate sugar epimerase
HICBILPI_03069 2.1e-25 yfhD S YfhD-like protein
HICBILPI_03070 1.7e-105 yfhC C nitroreductase
HICBILPI_03071 7.2e-161 yfhB 5.3.3.17 S PhzF family
HICBILPI_03072 0.0 mprF 2.3.2.3 S Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HICBILPI_03073 6.2e-82 yfiV K transcriptional
HICBILPI_03074 4.7e-288 yfiU EGP Major facilitator Superfamily
HICBILPI_03075 4.7e-21 yfiT S Belongs to the metal hydrolase YfiT family
HICBILPI_03076 4.5e-45 yrdF K ribonuclease inhibitor
HICBILPI_03077 0.0 2.7.9.2 GT phosphoenolpyruvate synthase
HICBILPI_03078 1.9e-179 yfiQ G COG3936 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HICBILPI_03079 7.9e-111 1.6.5.2 S NADPH-dependent FMN reductase
HICBILPI_03080 6.6e-96 padR K transcriptional
HICBILPI_03081 1.7e-163 cyoE 2.5.1.141 O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
HICBILPI_03082 2.1e-155 yfiE 1.13.11.2 S glyoxalase
HICBILPI_03083 9.2e-63 mhqP S DoxX
HICBILPI_03084 0.0 yfiC V COG1132 ABC-type multidrug transport system, ATPase and permease components
HICBILPI_03085 7.9e-222 yfiB3 V ABC transporter
HICBILPI_03086 7.3e-69 yfiB3 V ABC transporter
HICBILPI_03087 7.7e-80 glvC 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
HICBILPI_03088 1.5e-179 glvC 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
HICBILPI_03089 5.1e-139 glvR F Helix-turn-helix domain, rpiR family
HICBILPI_03090 2.2e-262 aglB 3.2.1.122, 3.2.1.22, 3.2.1.86 GH4,GT4 G COG1486 Alpha-galactosidases 6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases
HICBILPI_03091 4.2e-15 sspH S Belongs to the SspH family
HICBILPI_03092 3.8e-42 acoR KQ COG3284 Transcriptional activator of acetoin glycerol metabolism
HICBILPI_03093 6.3e-279 acoR KQ COG3284 Transcriptional activator of acetoin glycerol metabolism
HICBILPI_03094 2.3e-251 acoL 1.8.1.4 C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
HICBILPI_03095 1.4e-212 acoC 2.3.1.12, 2.3.1.61 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
HICBILPI_03096 4.7e-188 acoB C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
HICBILPI_03097 7.9e-137 acoA C COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
HICBILPI_03098 1.2e-34 acoA C COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
HICBILPI_03099 2.8e-87 yfjM S Psort location Cytoplasmic, score
HICBILPI_03100 3.5e-193 yfjN J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HICBILPI_03101 8.7e-44 S YfzA-like protein
HICBILPI_03102 1.8e-267 rumA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HICBILPI_03103 8.3e-162 yfjP 3.2.2.21 L COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HICBILPI_03104 8.5e-184 corA P Mediates influx of magnesium ions
HICBILPI_03105 3.3e-30
HICBILPI_03106 7.5e-147 yfjR 1.1.1.31 I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
HICBILPI_03107 9e-155 pdaA G deacetylase
HICBILPI_03108 4.9e-27 yfjT
HICBILPI_03109 7.3e-219 yfkA S YfkB-like domain
HICBILPI_03110 1e-145 yfkC M Mechanosensitive ion channel
HICBILPI_03111 1.6e-143 yfkD S YfkD-like protein
HICBILPI_03112 8.5e-185 cax P COG0387 Ca2 H antiporter
HICBILPI_03113 2.5e-217 ycaD EGP COG0477 Permeases of the major facilitator superfamily
HICBILPI_03114 2.5e-07
HICBILPI_03115 7.6e-144 yihY S Belongs to the UPF0761 family
HICBILPI_03116 1e-51 yfkI S gas vesicle protein
HICBILPI_03117 1.2e-27 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HICBILPI_03118 4.6e-35 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HICBILPI_03119 2.3e-29 yfkK S Belongs to the UPF0435 family
HICBILPI_03120 8.1e-192 ydiM EGP Major facilitator Superfamily
HICBILPI_03121 1.2e-135 aroD 1.1.1.25, 4.2.1.10 E Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
HICBILPI_03122 5.6e-169 aroE 1.1.1.25, 1.1.1.282, 1.3.5.4 E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HICBILPI_03123 9.8e-186 K helix_turn _helix lactose operon repressor
HICBILPI_03124 1.6e-91 yfkM 1.11.1.6, 3.5.1.124 S protease
HICBILPI_03125 0.0 cpdB 3.1.3.5, 3.1.3.6, 3.1.4.16 F COG0737 5'-nucleotidase 2',3'-cyclic phosphodiesterase and related esterases
HICBILPI_03126 9.4e-198 yibE S YibE/F-like protein
HICBILPI_03127 1e-123 yibF S YibE/F-like protein
HICBILPI_03128 1.2e-123 yfkO C nitroreductase
HICBILPI_03129 2e-129 treR K transcriptional
HICBILPI_03130 0.0 treC 3.2.1.93 GH13 G COG0366 Glycosidases
HICBILPI_03131 2.1e-239 treP 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
HICBILPI_03132 1.2e-39 ydgB S Spore germination protein gerPA/gerPF
HICBILPI_03133 3.6e-38 ydgA S Spore germination protein gerPA/gerPF
HICBILPI_03134 1.2e-79 cotP O Belongs to the small heat shock protein (HSP20) family
HICBILPI_03135 2.3e-63 yhdN S Domain of unknown function (DUF1992)
HICBILPI_03136 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
HICBILPI_03137 1.4e-72 yfmQ S Uncharacterised protein from bacillus cereus group
HICBILPI_03138 2.3e-246 nagE 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G COG1263 Phosphotransferase system IIC components, glucose maltose N-acetylglucosamine-specific
HICBILPI_03139 7.2e-138 map 3.4.11.18 E Methionine aminopeptidase
HICBILPI_03140 3.1e-50 yflH S Protein of unknown function (DUF3243)
HICBILPI_03141 7e-19 yflI
HICBILPI_03142 1.5e-14 yflJ S Protein of unknown function (DUF2639)
HICBILPI_03143 1.3e-122 yflK S protein conserved in bacteria
HICBILPI_03144 4.9e-44 acyP 3.6.1.7 C Belongs to the acylphosphatase family
HICBILPI_03145 6.7e-217 nos 1.14.14.47 C Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HICBILPI_03146 4.8e-148 yflN S COG0491 Zn-dependent hydrolases, including glyoxylases
HICBILPI_03147 3.6e-225 citM C Citrate transporter
HICBILPI_03148 4.6e-177 yflP S Tripartite tricarboxylate transporter family receptor
HICBILPI_03149 2.6e-118 citT T response regulator
HICBILPI_03150 6.2e-272 citS 2.7.13.3 T Signal transduction histidine kinase regulating citrate malate metabolism
HICBILPI_03151 4.6e-80 srtA 3.4.22.70 M Sortase family
HICBILPI_03152 0.0 M1-568 M cell wall anchor domain
HICBILPI_03153 2.8e-151 M1-574 T Transcriptional regulatory protein, C terminal
HICBILPI_03154 0.0 ywpD T PhoQ Sensor
HICBILPI_03155 2.5e-73 M1-820 Q Collagen triple helix repeat (20 copies)
HICBILPI_03158 5.9e-27 Q PFAM Collagen triple helix
HICBILPI_03159 3.5e-234 yflS P Sodium:sulfate symporter transmembrane region
HICBILPI_03160 1.7e-240 pel 4.2.2.10, 4.2.2.2 G Pectate lyase
HICBILPI_03161 1.3e-57 yflT S Heat induced stress protein YflT
HICBILPI_03162 2.7e-24 S Protein of unknown function (DUF3212)
HICBILPI_03163 7.9e-188 yfmJ S N-terminal domain of oxidoreductase
HICBILPI_03164 1.1e-43 yfmK 2.3.1.128 K acetyltransferase
HICBILPI_03165 5.7e-203 yfmL 3.6.4.13 L COG0513 Superfamily II DNA and RNA helicases
HICBILPI_03166 3.2e-297 yfmM S COG0488 ATPase components of ABC transporters with duplicated ATPase domains
HICBILPI_03167 2.6e-206 yfmO EGP Major facilitator Superfamily
HICBILPI_03168 1.8e-69 yfmP K transcriptional
HICBILPI_03169 0.0 yfmR S COG0488 ATPase components of ABC transporters with duplicated ATPase domains
HICBILPI_03170 2.3e-206 M COG0463 Glycosyltransferases involved in cell wall biogenesis
HICBILPI_03171 1.5e-166 IQ Enoyl-(Acyl carrier protein) reductase
HICBILPI_03172 7.5e-107 yfmS NT chemotaxis protein
HICBILPI_03173 3.8e-276 yfmT 1.2.1.3, 1.2.1.67 C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
HICBILPI_03174 3e-246 yfnA E amino acid
HICBILPI_03175 6.8e-218 fsr P COG0477 Permeases of the major facilitator superfamily
HICBILPI_03176 6.9e-186 yfnD M Nucleotide-diphospho-sugar transferase
HICBILPI_03177 6.2e-221 yfnE 2.4.1.338 GT2 S Glycosyltransferase like family 2
HICBILPI_03178 2.1e-179 yfnF M Nucleotide-diphospho-sugar transferase
HICBILPI_03179 2.4e-172 yfnG 4.2.1.45 M dehydratase
HICBILPI_03180 6.7e-147 rfbF 2.7.7.33 JM Nucleotidyl transferase
HICBILPI_03181 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
HICBILPI_03182 1.1e-242 cypD 1.14.14.1, 1.6.2.4 C Belongs to the cytochrome P450 family
HICBILPI_03183 0.0 cypD 1.14.14.1, 1.6.2.4 C Belongs to the cytochrome P450 family
HICBILPI_03184 3.4e-197 yetN S Protein of unknown function (DUF3900)
HICBILPI_03185 5.4e-206 yetM CH FAD binding domain
HICBILPI_03186 8e-88 yetL K helix_turn_helix multiple antibiotic resistance protein
HICBILPI_03187 2.4e-105 yetJ S Belongs to the BI1 family
HICBILPI_03188 5.3e-55 ribF 2.7.1.26, 2.7.7.2 H riboflavin kinase activity
HICBILPI_03189 1.2e-22 yezD S Uncharacterized small protein (DUF2292)
HICBILPI_03190 3.7e-154 T COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
HICBILPI_03191 3.4e-64 yetH E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HICBILPI_03192 1.7e-54 isdI 1.14.99.48, 1.14.99.57 S Antibiotic biosynthesis monooxygenase
HICBILPI_03193 2.1e-120 yetF S membrane
HICBILPI_03195 6.1e-67 yesJ K Acetyltransferase (GNAT) family
HICBILPI_03196 8.9e-104 cotJC P Spore Coat
HICBILPI_03197 1.3e-44 cotJB S CotJB protein
HICBILPI_03198 1.2e-44 cotJA S Spore coat associated protein JA (CotJA)
HICBILPI_03199 9e-108 aadK G Streptomycin adenylyltransferase
HICBILPI_03201 9.4e-127 yeeN K transcriptional regulatory protein
HICBILPI_03202 0.0 yobL L nucleic acid phosphodiester bond hydrolysis
HICBILPI_03203 4.8e-79 S Protein of unknown function, DUF600
HICBILPI_03204 1e-40 S Protein of unknown function, DUF600
HICBILPI_03205 4e-46 S Protein of unknown function, DUF600
HICBILPI_03206 2.1e-50 S Protein of unknown function, DUF600
HICBILPI_03207 1.3e-60 S Protein of unknown function, DUF600
HICBILPI_03208 2.2e-138 cylB V ABC-2 type transporter
HICBILPI_03209 1.6e-158 cylA V AAA domain, putative AbiEii toxin, Type IV TA system
HICBILPI_03210 8.1e-311 L Uncharacterized conserved protein (DUF2075)
HICBILPI_03211 2.4e-248 rumA 2.1.1.190 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HICBILPI_03212 1.1e-169 yegS 2.7.1.107 I COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
HICBILPI_03213 0.0 swrC V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HICBILPI_03214 7.1e-119 yerO K Transcriptional regulator
HICBILPI_03215 5.2e-270 gatB 6.1.1.12, 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HICBILPI_03216 3e-273 gatA 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
HICBILPI_03217 1.6e-45 gatC 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HICBILPI_03218 1.4e-262 putP E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HICBILPI_03219 1.3e-120 sapB S MgtC SapB transporter
HICBILPI_03220 7.5e-191 yerI S homoserine kinase type II (protein kinase fold)
HICBILPI_03221 2e-222 camS S COG4851 Protein involved in sex pheromone biosynthesis
HICBILPI_03222 0.0 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HICBILPI_03223 0.0 pcrA 3.6.4.12 L ATP-dependent DNA helicase
HICBILPI_03224 2.4e-127 pcrB I 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HICBILPI_03225 9.1e-220 yerD 1.4.7.1 E Belongs to the glutamate synthase family
HICBILPI_03226 3.5e-70 yerD 1.4.7.1 E Belongs to the glutamate synthase family
HICBILPI_03227 2.4e-50 yerC S protein conserved in bacteria
HICBILPI_03228 1.5e-191 yerB S Protein of unknown function (DUF3048) C-terminal domain
HICBILPI_03229 0.0 yerA 3.5.4.2 F adenine deaminase
HICBILPI_03230 2.6e-25 S Protein of unknown function (DUF2892)
HICBILPI_03231 4.5e-233 purD 6.3.4.13 F Belongs to the GARS family
HICBILPI_03232 3.9e-287 purH 2.1.2.3, 3.5.4.10 F Bifunctional purine biosynthesis protein PurH
HICBILPI_03233 9.1e-104 purN 2.1.2.2 F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HICBILPI_03234 1.9e-181 purM 6.3.3.1, 6.3.4.13 F Phosphoribosylformylglycinamidine cyclo-ligase
HICBILPI_03235 1.2e-269 purF 2.4.2.14 F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HICBILPI_03236 0.0 purL 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HICBILPI_03237 4.3e-129 purQ 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HICBILPI_03238 2.2e-38 purS 6.3.2.6, 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HICBILPI_03239 3.8e-128 purC 4.1.1.21, 4.3.2.2, 6.3.2.6 F Belongs to the SAICAR synthetase family
HICBILPI_03240 1.6e-246 purB 4.3.2.2 F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HICBILPI_03241 1.8e-223 purK 6.3.4.18 F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HICBILPI_03242 1.6e-82 purE 5.4.99.18 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HICBILPI_03243 5.5e-29 yebG S NETI protein
HICBILPI_03244 7.5e-92 yebE S UPF0316 protein
HICBILPI_03246 1.5e-125 yebC M Membrane
HICBILPI_03247 8.1e-209 pbuG S permease
HICBILPI_03248 2.8e-247 S Domain of unknown function (DUF4179)
HICBILPI_03249 1.9e-92 sigV K Belongs to the sigma-70 factor family. ECF subfamily
HICBILPI_03250 1.1e-302 guaA 2.3.1.128, 6.3.5.2 F Catalyzes the synthesis of GMP from XMP
HICBILPI_03251 0.0 yebA E COG1305 Transglutaminase-like enzymes
HICBILPI_03252 1.9e-206 yeaD S conserved protein (some members contain a von Willebrand factor type A (vWA) domain)
HICBILPI_03253 6.6e-176 yeaC S COG0714 MoxR-like ATPases
HICBILPI_03254 5.6e-245 gabP E COG1113 Gamma-aminobutyrate permease and related permeases
HICBILPI_03255 0.0 cotA 1.10.3.4, 1.16.3.3 Q multicopper oxidases
HICBILPI_03256 7.2e-35 ydjO S Cold-inducible protein YdjO
HICBILPI_03258 1.5e-133 ydjN U Involved in the tonB-independent uptake of proteins
HICBILPI_03259 1.2e-61 ydjM M Lytic transglycolase
HICBILPI_03260 3.4e-194 bdhA 1.1.1.303, 1.1.1.4 E Dehydrogenase
HICBILPI_03261 4.3e-86 sigV K Belongs to the sigma-70 factor family. ECF subfamily
HICBILPI_03262 1.4e-145 rsiV S Protein of unknown function (DUF3298)
HICBILPI_03263 0.0 yrhL I Acyltransferase family
HICBILPI_03264 4.1e-144 ydjI S virion core protein (lumpy skin disease virus)
HICBILPI_03265 3.8e-118 ydjH S COG1512 Beta-propeller domains of methanol dehydrogenase type
HICBILPI_03266 4.7e-180 ydjG 3.6.4.12 L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HICBILPI_03267 3.3e-113 pspA KT Phage shock protein A
HICBILPI_03268 3.6e-30 yjdJ S Domain of unknown function (DUF4306)
HICBILPI_03269 3.7e-171 ydjE 2.7.1.4 G pfkB family carbohydrate kinase
HICBILPI_03270 1.1e-248 gutA G MFS/sugar transport protein
HICBILPI_03271 1.9e-200 gutB 1.1.1.14 E Dehydrogenase
HICBILPI_03272 0.0 K NB-ARC domain
HICBILPI_03273 2.8e-17
HICBILPI_03274 2e-79 S NYN domain
HICBILPI_03275 3.9e-67 3.5.1.28 M Ami_2
HICBILPI_03276 2.2e-59 S Pfam:Phage_holin_4_1
HICBILPI_03281 3.2e-225 S peptidoglycan catabolic process
HICBILPI_03282 1e-46
HICBILPI_03283 1.6e-132
HICBILPI_03284 3.3e-25 S Phage tail assembly chaperone protein, TAC
HICBILPI_03285 7.2e-09 chiA 3.2.1.14 GH18 G Belongs to the glycosyl hydrolase 18 family
HICBILPI_03286 3.4e-33 N Bacterial Ig-like domain 2
HICBILPI_03287 7.7e-30 S Protein of unknown function (DUF3168)
HICBILPI_03288 2.3e-27 S Bacteriophage HK97-gp10, putative tail-component
HICBILPI_03290 4.3e-29 S Phage head-tail joining protein
HICBILPI_03291 2.3e-37 S Phage gp6-like head-tail connector protein
HICBILPI_03294 2e-145 S Phage capsid family
HICBILPI_03295 3e-59 S Domain of unknown function (DUF4355)
HICBILPI_03296 4.3e-92 S Phage Mu protein F like protein
HICBILPI_03297 1.8e-198 S Phage portal protein, SPP1 Gp6-like
HICBILPI_03298 7.5e-185 ps334 S Terminase-like family
HICBILPI_03299 1.5e-82 yqaS L DNA packaging
HICBILPI_03302 3.9e-12 K Transcriptional regulator
HICBILPI_03304 2.1e-67 xpf K COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog
HICBILPI_03308 8.4e-46
HICBILPI_03310 5.5e-71
HICBILPI_03311 2.4e-105 2.1.1.72 L D12 class N6 adenine-specific DNA methyltransferase
HICBILPI_03315 1.5e-16 yqaO S Phage-like element PBSX protein XtrA
HICBILPI_03317 5e-59 rusA L Endodeoxyribonuclease RusA
HICBILPI_03319 5.5e-122 xkdC L IstB-like ATP binding protein
HICBILPI_03320 9.6e-76 3.1.3.16 L DnaD domain protein
HICBILPI_03322 5.8e-69 pi112 3.6.4.12 L PDDEXK-like domain of unknown function (DUF3799)
HICBILPI_03323 1.2e-99
HICBILPI_03327 4.2e-85
HICBILPI_03328 4.3e-61 S DNA binding
HICBILPI_03329 5e-32
HICBILPI_03330 6.2e-22
HICBILPI_03332 4.1e-20 K Helix-turn-helix XRE-family like proteins
HICBILPI_03333 2.3e-44 xre K Helix-turn-helix XRE-family like proteins
HICBILPI_03334 4.5e-25 S Short C-terminal domain
HICBILPI_03335 2.8e-45 xkdA E IrrE N-terminal-like domain
HICBILPI_03336 9.9e-145 L Belongs to the 'phage' integrase family
HICBILPI_03337 7.5e-281 groL O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
HICBILPI_03338 1.3e-42 groS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HICBILPI_03339 4.3e-127 ydiL S CAAX protease self-immunity
HICBILPI_03340 1.7e-27 ydiK S Domain of unknown function (DUF4305)
HICBILPI_03341 3.2e-125 tatC U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HICBILPI_03342 1.7e-18 tatA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
HICBILPI_03343 3e-116 rex K Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HICBILPI_03344 1.2e-88 moaC 4.6.1.17 H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)
HICBILPI_03345 9e-54 ydiF S ABC transporter
HICBILPI_03346 3.2e-273 ydiF S ABC transporter
HICBILPI_03347 8.1e-188 tsaD 2.3.1.234 O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HICBILPI_03348 2.4e-83 rimI 2.3.1.128 K This enzyme acetylates the N-terminal alanine of ribosomal protein S18
HICBILPI_03349 4.6e-123 yeaZ 2.3.1.234 O COG1214 Inactive homolog of metal-dependent proteases
HICBILPI_03350 3.5e-85 ydiB 2.7.1.221, 5.1.1.1 S ATPase or kinase
HICBILPI_03351 1.3e-182 thiL 2.7.4.16 H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HICBILPI_03353 7.8e-08
HICBILPI_03354 3.4e-39 S COG NOG14552 non supervised orthologous group
HICBILPI_03357 1.2e-250 iolT EGP Major facilitator Superfamily
HICBILPI_03358 1.5e-183 yhfP 1.1.1.1 C Quinone oxidoreductase
HICBILPI_03359 1.7e-81 yndB S Activator of Hsp90 ATPase homolog 1-like protein
HICBILPI_03360 1.9e-163 ydhU P Catalase
HICBILPI_03361 2.1e-296 yveA E amino acid
HICBILPI_03362 2.9e-102 yvdT K Transcriptional regulator
HICBILPI_03363 2.3e-51 ykkC P Small Multidrug Resistance protein
HICBILPI_03364 2.6e-49 sugE P Small Multidrug Resistance protein
HICBILPI_03365 8.2e-216 yeaN P COG2807 Cyanate permease
HICBILPI_03366 9.9e-118 K FCD
HICBILPI_03367 1.5e-132 ydhQ K UTRA
HICBILPI_03368 2e-195 pbuE EGP Major facilitator Superfamily
HICBILPI_03369 5.5e-98 ydhK M Protein of unknown function (DUF1541)
HICBILPI_03371 5.5e-261 pbpE V Beta-lactamase
HICBILPI_03374 3.5e-227 ydhE CG COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase
HICBILPI_03375 2.4e-119 ydhC K FCD
HICBILPI_03376 1.6e-33 ycsA 1.1.1.83, 1.1.1.93, 4.1.1.73 CE Tartrate dehydrogenase
HICBILPI_03379 2.1e-82 ycsA 1.1.1.83, 1.1.1.93, 4.1.1.73 CE Tartrate dehydrogenase
HICBILPI_03380 2.4e-144 ycgJ_1 Q ubiE/COQ5 methyltransferase family
HICBILPI_03381 1.9e-112 yjhB 3.6.1.13, 3.6.1.55 F ADP-ribose pyrophosphatase
HICBILPI_03382 1.2e-147 ydzE EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
HICBILPI_03383 7.6e-149 bltR K helix_turn_helix, mercury resistance
HICBILPI_03384 2.2e-81 bltD 2.3.1.57 K FR47-like protein
HICBILPI_03385 9.4e-122 ydhB S membrane transporter protein
HICBILPI_03386 5e-156 K Helix-turn-helix XRE-family like proteins
HICBILPI_03387 3.7e-224 fabF_1 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
HICBILPI_03388 3.9e-210 tcaB EGP Major facilitator Superfamily
HICBILPI_03389 5e-196 gldA 1.1.1.6 C COG0371 Glycerol dehydrogenase and related enzymes
HICBILPI_03390 2.5e-150 S Uncharacterized protein conserved in bacteria (DUF2179)
HICBILPI_03391 2.3e-98 ynaD J Acetyltransferase (GNAT) domain
HICBILPI_03392 1.5e-297 expZ S ABC transporter
HICBILPI_03393 6.7e-133 puuD S Peptidase C26
HICBILPI_03394 0.0 ydfJ S drug exporters of the RND superfamily
HICBILPI_03395 6e-109 ydfI K Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HICBILPI_03396 3.9e-216 ydfH 2.7.13.3 T Histidine kinase
HICBILPI_03397 1.3e-35 yraG
HICBILPI_03398 8.4e-63 yraF M Spore coat protein
HICBILPI_03399 1.5e-219 adhB 1.1.1.1, 1.1.1.14, 1.1.1.284 E COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
HICBILPI_03400 3.1e-24 yraE
HICBILPI_03401 1.4e-47 yraD M Spore coat protein
HICBILPI_03402 1.9e-17 ydeS K Transcriptional regulator
HICBILPI_03403 1.2e-100 ydeS K Transcriptional regulator
HICBILPI_03404 1.1e-177 ydeR EGP Major facilitator Superfamily
HICBILPI_03406 3e-113 paiB K Transcriptional regulator
HICBILPI_03407 8.3e-257 K helix_turn_helix gluconate operon transcriptional repressor
HICBILPI_03408 4.3e-223 mleN_2 C antiporter
HICBILPI_03409 3.6e-67 yraB K helix_turn_helix, mercury resistance
HICBILPI_03410 3.8e-201 adhA 1.1.1.1 C alcohol dehydrogenase
HICBILPI_03411 2.6e-164 S Sodium Bile acid symporter family
HICBILPI_03412 1.7e-50 ydeH
HICBILPI_03413 6.9e-195 rlmN 2.1.1.192, 2.1.1.224 J Specifically methylates position 8 of adenine 2503 in 23S rRNA. Confers resistance to some classes of antibiotics
HICBILPI_03415 3.3e-149 dapA_5 4.3.3.7 EM Dihydrodipicolinate synthetase family
HICBILPI_03416 1.8e-14 ykkA S Protein of unknown function (DUF664)
HICBILPI_03419 2.6e-194 trkA P Oxidoreductase
HICBILPI_03420 8.4e-168 czcD P COG1230 Co Zn Cd efflux system component
HICBILPI_03421 1.2e-09 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HICBILPI_03422 6.6e-267 ygaK C COG0277 FAD FMN-containing dehydrogenases
HICBILPI_03425 5.1e-44 G Cupin domain
HICBILPI_03426 5.5e-83 S DinB superfamily
HICBILPI_03427 2.3e-181 S Patatin-like phospholipase
HICBILPI_03428 4.9e-51 K Transcriptional regulator PadR-like family
HICBILPI_03429 4.1e-101 S Protein of unknown function (DUF2812)
HICBILPI_03430 3.7e-117 racX 5.1.1.13 M Belongs to the aspartate glutamate racemases family
HICBILPI_03431 1.2e-116 yrkJ S membrane transporter protein
HICBILPI_03432 7.8e-35 yrkI O Belongs to the sulfur carrier protein TusA family
HICBILPI_03433 1.2e-200 yrkH P Rhodanese Homology Domain
HICBILPI_03434 5e-99 yrkF OP Belongs to the sulfur carrier protein TusA family
HICBILPI_03435 5.6e-83 yrkE O DsrE/DsrF/DrsH-like family
HICBILPI_03436 9.2e-40 yrkD S protein conserved in bacteria
HICBILPI_03437 1.4e-30 cspL K Cold shock
HICBILPI_03438 1.9e-110 ywnB S NAD(P)H-binding
HICBILPI_03439 1.6e-71 ywnA K Transcriptional regulator
HICBILPI_03440 3.2e-64 yyaQ S YjbR
HICBILPI_03441 1e-72 maoC I N-terminal half of MaoC dehydratase
HICBILPI_03442 1.1e-33 S Domain of unknown function with cystatin-like fold (DUF4467)
HICBILPI_03443 8.3e-23 S Domain of unknown function with cystatin-like fold (DUF4467)
HICBILPI_03444 1.4e-48 ohrR K Transcriptional regulator
HICBILPI_03445 4.8e-46 ohrB O OsmC-like protein
HICBILPI_03446 1.9e-135 I esterase
HICBILPI_03447 5.7e-229 proP EGP Transporter
HICBILPI_03448 2e-149 S Serine aminopeptidase, S33
HICBILPI_03449 1.1e-95 ywrO S Flavodoxin-like fold
HICBILPI_03457 8.6e-59 ydcK S Belongs to the SprT family
HICBILPI_03458 1.7e-14
HICBILPI_03459 0.0 yhgF K COG2183 Transcriptional accessory protein
HICBILPI_03460 1.8e-107 rsbX 3.1.3.16, 3.1.3.3 KT Sigma factor PP2C-like phosphatases
HICBILPI_03461 1.4e-139 sigB K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HICBILPI_03462 1e-84 rsbW 2.7.11.1 F Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B)
HICBILPI_03463 1.4e-53 rsbV T Belongs to the anti-sigma-factor antagonist family
HICBILPI_03464 1.7e-187 rsbU 3.1.3.3 KT phosphatase
HICBILPI_03465 3.8e-69 rsbT 2.7.11.1 T COG2172 Anti-sigma regulatory factor (Ser Thr protein kinase)
HICBILPI_03466 1.8e-57 rsbS T antagonist
HICBILPI_03467 2.3e-145 rsbR T Positive regulator of sigma-B
HICBILPI_03468 2.5e-56 ndoA L Toxic component of a toxin-antitoxin (TA) module
HICBILPI_03469 8.1e-42 ndoAI K transcriptional regulators containing the CopG Arc MetJ DNA-binding domain and a metal-binding domain
HICBILPI_03470 2.6e-219 alr 5.1.1.1, 5.1.1.5 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HICBILPI_03471 5.8e-183 ydcC M COG2834 Outer membrane lipoprotein-sorting protein
HICBILPI_03472 6.8e-57 acpS 2.7.6.3, 2.7.8.7, 5.1.1.1 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
HICBILPI_03473 1.4e-107 ydcA 3.4.21.105 S membrane protein (homolog of Drosophila rhomboid)
HICBILPI_03474 7.7e-261 ydbT S Membrane
HICBILPI_03475 1.3e-60 ydbS S Bacterial PH domain
HICBILPI_03476 1.4e-246 cshA 3.6.4.13 JKL DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
HICBILPI_03477 1e-254 murF 6.3.2.10 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
HICBILPI_03478 2.3e-201 ddl 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
HICBILPI_03479 8.5e-56 ydbP 2.7.1.180, 5.3.4.1 CO Thioredoxin
HICBILPI_03480 3.4e-118 yeaB P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HICBILPI_03481 5.8e-09 S Fur-regulated basic protein A
HICBILPI_03482 1.5e-10 S Fur-regulated basic protein B
HICBILPI_03483 6.8e-204 ydbM 1.3.8.1 I acyl-CoA dehydrogenase
HICBILPI_03484 4.6e-52 ydbL
HICBILPI_03485 3.7e-129 ydbK S COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
HICBILPI_03486 2.3e-170 ydbJ V ABC transporter, ATP-binding protein
HICBILPI_03487 4e-158 ydbI S AI-2E family transporter
HICBILPI_03488 5e-224 dctA U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
HICBILPI_03489 3.9e-119 dctR T COG4565 Response regulator of citrate malate metabolism
HICBILPI_03490 1.6e-299 dctS 2.7.13.3 T Signal transduction histidine kinase regulating citrate malate metabolism
HICBILPI_03491 1.6e-199 dctB G COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component
HICBILPI_03492 1.2e-154 ydbD P Catalase
HICBILPI_03493 8.5e-60 ydbC S Domain of unknown function (DUF4937
HICBILPI_03494 1e-40 ydbB G Cupin domain
HICBILPI_03496 1.7e-140 ydbA 3.6.3.4, 3.6.3.54 P EcsC protein family
HICBILPI_03497 1.2e-53 yvaE P Small Multidrug Resistance protein
HICBILPI_03498 6.5e-34 ydaT
HICBILPI_03500 2.7e-225 mntH P H( )-stimulated, divalent metal cation uptake system
HICBILPI_03501 1.8e-38
HICBILPI_03502 1.6e-97
HICBILPI_03503 2.5e-74
HICBILPI_03505 6.5e-13
HICBILPI_03507 1.1e-206 S Histidine kinase
HICBILPI_03509 2.2e-67
HICBILPI_03510 4.8e-41 xlyA 3.5.1.28 M N-acetylmuramoyl-L-alanine amidase
HICBILPI_03511 0.0 poxB 1.2.3.3, 1.2.5.1 EH Belongs to the TPP enzyme family
HICBILPI_03512 2.8e-73 mutT 3.6.1.13, 3.6.1.55 L Belongs to the Nudix hydrolase family
HICBILPI_03513 0.0 ydaO E amino acid
HICBILPI_03514 0.0 ydaN S Bacterial cellulose synthase subunit
HICBILPI_03515 2.1e-149 ydaM M Glycosyl transferase family group 2
HICBILPI_03516 1.9e-57 ydaM M Glycosyl transferase family group 2
HICBILPI_03517 0.0 ydaL S Uncharacterized protein conserved in bacteria (DUF2334)
HICBILPI_03518 2.5e-147 ydaK T Diguanylate cyclase, GGDEF domain
HICBILPI_03519 2.8e-199 ydaJ M Belongs to the glycosyl hydrolase 8 (cellulase D) family
HICBILPI_03520 0.0 topB 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HICBILPI_03521 4.3e-74 lrpC K Transcriptional regulator
HICBILPI_03522 1.3e-47 ydzA EGP Major facilitator Superfamily
HICBILPI_03523 1.2e-138 amj U Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane
HICBILPI_03524 1.4e-77 ydaG 1.4.3.5 S general stress protein
HICBILPI_03525 3.2e-115 rimL 1.1.1.25 J COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
HICBILPI_03526 1e-95 MA20_27600 5.3.1.15 S Cupin 2, conserved barrel domain protein
HICBILPI_03527 2e-160 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HICBILPI_03528 5.5e-286 ydaB IQ acyl-CoA ligase
HICBILPI_03529 0.0 mtlR K transcriptional regulator, MtlR
HICBILPI_03530 1.6e-171 ydhF S Oxidoreductase
HICBILPI_03531 0.0 pbpC 3.4.16.4 M Penicillin-binding Protein
HICBILPI_03532 5.1e-56 yczJ S biosynthesis
HICBILPI_03534 2.5e-115 ycsK E anatomical structure formation involved in morphogenesis
HICBILPI_03535 1.3e-129 kipR K Transcriptional regulator
HICBILPI_03536 1.2e-188 kipA 6.3.4.6 E Allophanate hydrolase subunit 2
HICBILPI_03537 1.9e-135 kipI 3.5.1.54 E Allophanate hydrolase subunit 1
HICBILPI_03538 2.5e-149 ycsI S Belongs to the D-glutamate cyclase family
HICBILPI_03539 5.7e-209 ycsG P COG1914 Mn2 and Fe2 transporters of the NRAMP family
HICBILPI_03540 3.9e-139 ycsF S Belongs to the UPF0271 (lamB) family
HICBILPI_03541 8e-137 ycsE 3.1.3.104 S Sucrose-6F-phosphate phosphohydrolase
HICBILPI_03543 1.3e-66 fabZ 3.5.1.108, 4.2.1.59 I FabA-like domain
HICBILPI_03544 7.1e-40 mtlD 1.1.1.17 G COG0246 Mannitol-1-phosphate altronate dehydrogenases
HICBILPI_03545 1.2e-149 mtlD 1.1.1.17 G COG0246 Mannitol-1-phosphate altronate dehydrogenases
HICBILPI_03546 8.8e-72 mtlF 2.7.1.197 G COG4668 Mannitol fructose-specific phosphotransferase system, IIA domain
HICBILPI_03547 2.2e-71 mtlA 2.7.1.197 G COG2213 Phosphotransferase system, mannitol-specific IIBC component
HICBILPI_03548 1.7e-137 mtlA 2.7.1.197 G COG2213 Phosphotransferase system, mannitol-specific IIBC component
HICBILPI_03549 1.6e-55
HICBILPI_03550 9.5e-106 ycnK K COG1349 Transcriptional regulators of sugar metabolism
HICBILPI_03551 3.3e-297 ycnJ P protein, homolog of Cu resistance protein CopC
HICBILPI_03552 2.3e-97 ycnI S protein conserved in bacteria
HICBILPI_03553 1.1e-144 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HICBILPI_03554 3.6e-149 glcU U Glucose uptake
HICBILPI_03555 4.1e-264 gabD 1.2.1.16, 1.2.1.20, 1.2.1.79 C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
HICBILPI_03556 4.2e-218 gabT 2.6.1.19, 2.6.1.22 E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HICBILPI_03557 7e-259 gabR K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
HICBILPI_03558 1.5e-52 yczG K helix_turn_helix, Arsenical Resistance Operon Repressor
HICBILPI_03559 1e-44 ycnE S Monooxygenase
HICBILPI_03560 2e-135 nfrA2 1.5.1.38, 1.5.1.39 C Nitroreductase family
HICBILPI_03561 3e-151 ycnC K Transcriptional regulator
HICBILPI_03562 6.2e-247 ycnB EGP Major facilitator Superfamily
HICBILPI_03563 6e-174 yclQ P COG4607 ABC-type enterochelin transport system, periplasmic component
HICBILPI_03564 1.8e-136 yclP 3.6.3.34 P ABC transporter, ATP-binding protein
HICBILPI_03565 2.3e-165 fatC P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HICBILPI_03566 1.2e-164 yclN P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HICBILPI_03567 4.5e-247 lysC 2.7.2.4 E Belongs to the aspartokinase family
HICBILPI_03569 1.6e-80 S aspartate phosphatase
HICBILPI_03570 4.1e-259 T PhoQ Sensor
HICBILPI_03571 1.1e-121 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HICBILPI_03572 5.9e-229 yclI V ABC transporter (permease) YclI
HICBILPI_03573 4e-119 yclH P ABC transporter
HICBILPI_03574 3.3e-250 yxeQ S MmgE/PrpD family
HICBILPI_03575 1.9e-217 yxeP 3.5.1.47 E hydrolase activity
HICBILPI_03576 1.2e-132 yxeO 3.6.3.21 P ABC transporter, ATP-binding protein
HICBILPI_03577 6.9e-92 yxeN P COG0765 ABC-type amino acid transport system, permease component
HICBILPI_03578 2.1e-140 yxeM M Belongs to the bacterial solute-binding protein 3 family
HICBILPI_03579 1.8e-92 yxeL K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HICBILPI_03580 1.3e-254 yxeK C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HICBILPI_03581 1.1e-195 gerKB F Spore germination protein
HICBILPI_03582 5.2e-234 gerKC S spore germination
HICBILPI_03583 7.8e-294 gerKA EG Spore germination protein
HICBILPI_03585 9.3e-277 yclG M Pectate lyase superfamily protein
HICBILPI_03586 1.2e-269 dtpT E amino acid peptide transporter
HICBILPI_03587 4.8e-76 yclD
HICBILPI_03588 1.7e-37 bsdD 4.1.1.61 S response to toxic substance
HICBILPI_03589 1.7e-181 yclC 4.1.1.61 H Decarboxylase involved in the decarboxylation and detoxification of phenolic derivatives under both aerobic and anaerobic conditions. It is able to catalyze the reversible decarboxylation of 4-hydroxybenzoate
HICBILPI_03590 3e-71 yclC 4.1.1.61 H Decarboxylase involved in the decarboxylation and detoxification of phenolic derivatives under both aerobic and anaerobic conditions. It is able to catalyze the reversible decarboxylation of 4-hydroxybenzoate
HICBILPI_03591 9.3e-101 ubiX 2.5.1.129 H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN
HICBILPI_03592 3.9e-159 bsdA K LysR substrate binding domain
HICBILPI_03593 5.5e-144 tcyA ET Belongs to the bacterial solute-binding protein 3 family
HICBILPI_03594 6.4e-120 tcyB P COG0765 ABC-type amino acid transport system, permease component
HICBILPI_03595 1.2e-132 tcyC 3.6.3.21 E COG1126 ABC-type polar amino acid transport system, ATPase component
HICBILPI_03596 1.7e-108 yczE S membrane
HICBILPI_03597 6.1e-128 acpT 2.7.8.7 H Belongs to the P-Pant transferase superfamily
HICBILPI_03598 3e-248 bamJ E Aminotransferase class I and II
HICBILPI_03599 3.4e-140 srfAD Q thioesterase
HICBILPI_03600 0.0 srfAC Q COG1020 Non-ribosomal peptide synthetase modules and related proteins
HICBILPI_03601 0.0 srfAB Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HICBILPI_03602 0.0 srfAA Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HICBILPI_03603 2.6e-61 hxlR K transcriptional
HICBILPI_03604 4.7e-106 hxlA 4.1.2.43 G 3-hexulose-6-phosphate synthase
HICBILPI_03605 1.6e-94 hxlB 4.1.2.43, 5.3.1.27 G SIS domain
HICBILPI_03606 2.4e-77 nucA M Deoxyribonuclease NucA/NucB
HICBILPI_03607 1.5e-65 nin S Competence protein J (ComJ)
HICBILPI_03608 9e-11 yckE 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
HICBILPI_03609 1.3e-48 S Protein of unknown function (DUF2680)
HICBILPI_03610 3.1e-72 yckC S membrane
HICBILPI_03611 2e-219 adhB 1.1.1.1, 1.1.1.14, 1.1.1.284 E COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
HICBILPI_03612 6.6e-226 yciC S GTPases (G3E family)
HICBILPI_03613 0.0 nirB 1.7.1.15 C Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HICBILPI_03614 1.1e-55 nirD 1.7.1.15 P Nitrite reductase
HICBILPI_03615 1.9e-275 cobA 2.1.1.107, 4.2.1.75 H Belongs to the precorrin methyltransferase family
HICBILPI_03616 1.9e-189 ycgT 1.18.1.2, 1.19.1.1 C Ferredoxin--NADP reductase
HICBILPI_03617 1.2e-227 ycgP QT COG2508 Regulator of polyketide synthase expression
HICBILPI_03618 5.8e-245 putP E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HICBILPI_03619 1.2e-291 rocA 1.2.1.88, 1.5.5.2 C Belongs to the aldehyde dehydrogenase family. RocA subfamily
HICBILPI_03620 1.9e-169 ycgM E Proline dehydrogenase
HICBILPI_03621 5.8e-146 ycgL S Predicted nucleotidyltransferase
HICBILPI_03622 1.5e-183 cah 3.1.1.41 Q Acetyl xylan esterase (AXE1)
HICBILPI_03623 4.3e-103 aroK 2.7.1.71, 4.2.3.4 F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HICBILPI_03624 4.8e-222 G COG0477 Permeases of the major facilitator superfamily
HICBILPI_03625 2.5e-141 4.2.1.118 G Xylose isomerase-like TIM barrel
HICBILPI_03626 1.4e-107 tmrB S AAA domain
HICBILPI_03628 8.7e-116 nadE 6.3.1.5 H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
HICBILPI_03629 7.6e-114 ycgI S Domain of unknown function (DUF1989)
HICBILPI_03630 5.4e-245 ycgH E COG1113 Gamma-aminobutyrate permease and related permeases
HICBILPI_03631 7.6e-151 yqcI S YqcI/YcgG family
HICBILPI_03632 3e-113 ycgF E Lysine exporter protein LysE YggA
HICBILPI_03633 3.7e-76 emrR K helix_turn_helix multiple antibiotic resistance protein
HICBILPI_03634 8.1e-261 mdr EGP Major facilitator Superfamily
HICBILPI_03635 1.6e-177 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
HICBILPI_03636 0.0 amyE 3.2.1.1 GH13 G alpha-amylase
HICBILPI_03637 1.5e-80 ycgB
HICBILPI_03638 2.5e-227 ycgA S Membrane
HICBILPI_03639 2.4e-209 amhX S amidohydrolase
HICBILPI_03640 1.5e-163 opuAC E glycine betaine
HICBILPI_03641 1.6e-138 opuAB P glycine betaine
HICBILPI_03642 3.9e-229 proV 3.6.3.32 E glycine betaine
HICBILPI_03643 2e-214 naiP P Uncharacterised MFS-type transporter YbfB
HICBILPI_03644 6.7e-193 yceH P Belongs to the TelA family
HICBILPI_03645 0.0 yceG S Putative component of 'biosynthetic module'
HICBILPI_03646 9.7e-138 terC P Protein of unknown function (DUF475)
HICBILPI_03647 1e-107 yceE T proteins involved in stress response, homologs of TerZ and
HICBILPI_03648 6.3e-105 yceD T proteins involved in stress response, homologs of TerZ and
HICBILPI_03649 1.3e-108 yceC 3.5.4.33 T proteins involved in stress response, homologs of TerZ and
HICBILPI_03650 2e-183 yceB C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HICBILPI_03651 9.8e-136 adcB P COG1108 ABC-type Mn2 Zn2 transport systems, permease components
HICBILPI_03652 2.5e-132 adcC P 'COG1121 ABC-type Mn Zn transport systems, ATPase component'
HICBILPI_03653 2.3e-163 adcA P Belongs to the bacterial solute-binding protein 9 family
HICBILPI_03654 8.1e-168 ycdG 3.2.1.10 GH13 G COG0366 Glycosidases
HICBILPI_03655 1.1e-149 ycdG 3.2.1.10 GH13 G COG0366 Glycosidases
HICBILPI_03656 3.1e-139 IQ Enoyl-(Acyl carrier protein) reductase
HICBILPI_03657 1.3e-151 S response regulator aspartate phosphatase
HICBILPI_03658 5.8e-91 cwlK M D-alanyl-D-alanine carboxypeptidase
HICBILPI_03659 1.3e-265 ycdC K Belongs to the sigma-70 factor family. ECF subfamily
HICBILPI_03660 2.9e-257 ycdB K Belongs to the sigma-70 factor family. ECF subfamily
HICBILPI_03661 1.5e-175 ycdA S Domain of unknown function (DUF5105)
HICBILPI_03662 6.2e-171 yccK C Aldo keto reductase
HICBILPI_03663 7e-195 yccF K DNA-templated transcriptional preinitiation complex assembly
HICBILPI_03664 5.7e-115 lip 3.1.1.3 S acetyltransferases and hydrolases with the alpha beta hydrolase fold
HICBILPI_03665 2.5e-195 ansB 3.5.1.1 EJ COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D
HICBILPI_03666 6.5e-99 yxaF K Transcriptional regulator
HICBILPI_03667 1e-241 lmrB EGP the major facilitator superfamily
HICBILPI_03668 6e-205 ycbU E Selenocysteine lyase
HICBILPI_03669 2.7e-117 pcp 3.4.19.3 O Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HICBILPI_03670 1.3e-120 tatC U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HICBILPI_03671 4.4e-26 tatA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
HICBILPI_03672 0.0 phoD 3.1.3.1 P COG3540 Phosphodiesterase alkaline phosphatase D
HICBILPI_03673 5.3e-77 sleB 3.5.1.28 M Cell wall
HICBILPI_03674 5.6e-62 ycbP S Protein of unknown function (DUF2512)
HICBILPI_03675 2.4e-56 traF CO Thioredoxin
HICBILPI_03676 4.4e-62 mhqP S DoxX
HICBILPI_03677 4.4e-185 ydfO E COG0346 Lactoylglutathione lyase and related lyases
HICBILPI_03678 4.5e-109 ydfN C nitroreductase
HICBILPI_03679 2.3e-154 fieF P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HICBILPI_03680 1.2e-24 rtpA K Tryptophan RNA-binding attenuator protein inhibitory protein
HICBILPI_03681 1.1e-124 ycbJ S Macrolide 2'-phosphotransferase
HICBILPI_03682 2.2e-171 glnL T Regulator
HICBILPI_03683 3.6e-98 phoQ 2.7.13.3 T Histidine kinase
HICBILPI_03684 6e-28 phoQ 2.7.13.3 T Histidine kinase
HICBILPI_03685 5.9e-188 glsA 3.5.1.2 E Belongs to the glutaminase family
HICBILPI_03686 2.7e-258 agcS E Sodium alanine symporter
HICBILPI_03687 1.5e-180 mmuM 1.5.1.20, 2.1.1.10 H homocysteine
HICBILPI_03688 1.5e-256 mmuP E amino acid
HICBILPI_03689 9.5e-200 ilvE 2.6.1.42 E Branched-chain amino acid aminotransferase
HICBILPI_03690 9.3e-215 gltP C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
HICBILPI_03691 2.5e-191 yceA S Belongs to the UPF0176 family
HICBILPI_03692 6.1e-42 ybfN
HICBILPI_03693 7.3e-152 psd 4.1.1.65 I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)
HICBILPI_03694 1.9e-86 ybfM S SNARE associated Golgi protein
HICBILPI_03695 8.6e-93 pssA 2.7.8.8 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HICBILPI_03696 1.2e-211 purT 2.1.2.2 F Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HICBILPI_03697 2.3e-193 gldA 1.1.1.1, 1.1.1.6 C COG0371 Glycerol dehydrogenase and related enzymes
HICBILPI_03698 1.2e-82 K Helix-turn-helix XRE-family like proteins
HICBILPI_03699 9.2e-32
HICBILPI_03700 0.0 ybfG 3.2.1.132 M Domain of unknown function (DUF1906)
HICBILPI_03702 2.1e-210 hpaB 1.14.14.9 Q COG2368 Aromatic ring hydroxylase
HICBILPI_03703 1e-16 S Protein of unknown function (DUF2651)
HICBILPI_03704 1.7e-259 glpT G -transporter
HICBILPI_03705 3.7e-165 glpQ 3.1.4.46 C glycerophosphoryl diester phosphodiesterase
HICBILPI_03706 1.6e-213 ybeC E amino acid
HICBILPI_03707 2.9e-57 ybeC E amino acid
HICBILPI_03708 9.2e-40 ybyB
HICBILPI_03709 1.8e-106 yqeB
HICBILPI_03710 7.5e-39 csgA S Sigma-G-dependent sporulation-specific SASP protein
HICBILPI_03711 8.5e-76 S Domain of unknown function (DUF4879)
HICBILPI_03712 5.1e-49 crtF 2.1.1.210 Q PFAM O-methyltransferase
HICBILPI_03713 0.0 Q TIGRFAM amino acid adenylation domain
HICBILPI_03714 1.2e-102 Q Flavin containing amine oxidoreductase
HICBILPI_03715 0.0 Q Polyketide synthase modules and related proteins
HICBILPI_03716 0.0 Q Beta-ketoacyl synthase
HICBILPI_03717 8.7e-120 fabD 2.3.1.39 I PFAM Acyl transferase
HICBILPI_03718 0.0 Q Non-ribosomal peptide synthetase modules and related proteins
HICBILPI_03719 0.0 Q Non-ribosomal peptide synthetase modules and related proteins
HICBILPI_03720 3.4e-48 bacT Q Thioesterase domain
HICBILPI_03721 4.4e-14
HICBILPI_03722 3.9e-122 V ABC-2 type transporter
HICBILPI_03723 6.8e-146 V ABC-2 type transporter
HICBILPI_03724 3.5e-134 V ABC transporter, ATP-binding protein
HICBILPI_03725 3.8e-82 KT helix_turn_helix, Lux Regulon
HICBILPI_03726 6.2e-104 T Histidine kinase
HICBILPI_03727 7.7e-70 yjjG 3.1.3.102, 3.1.3.104, 3.1.3.5, 3.8.1.2 S Haloacid dehalogenase-like hydrolase
HICBILPI_03728 4.5e-25 yjjG 3.1.3.102, 3.1.3.104, 3.1.3.5, 3.8.1.2 S Haloacid dehalogenase-like hydrolase
HICBILPI_03729 3.1e-259 yifK E COG1113 Gamma-aminobutyrate permease and related permeases
HICBILPI_03730 4.9e-70 yxaD K helix_turn_helix multiple antibiotic resistance protein
HICBILPI_03731 6.9e-52 S LrgA family
HICBILPI_03732 2.9e-93 yxaC M effector of murein hydrolase
HICBILPI_03733 3.3e-163 dkgB S Aldo/keto reductase family
HICBILPI_03734 3.7e-106 S ABC-2 family transporter protein
HICBILPI_03735 7.6e-155 V ATPases associated with a variety of cellular activities
HICBILPI_03736 0.0 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
HICBILPI_03737 1e-251 glmM 5.4.2.10 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HICBILPI_03738 1.3e-223 ybbR S protein conserved in bacteria
HICBILPI_03739 1.8e-145 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HICBILPI_03740 1.3e-116 rsiW K Is the anti-sigma factor for SigW. The presence of RsiW leads to the inactivation of SigW, and its proteolytic destruction to sigma-W activation
HICBILPI_03741 1.4e-98 sigW K Belongs to the sigma-70 factor family. ECF subfamily
HICBILPI_03747 3.9e-78 ybbK 2.4.2.1, 6.3.2.4 S Protein of unknown function (DUF523)
HICBILPI_03748 7.7e-85 ybbJ J acetyltransferase
HICBILPI_03749 2.9e-160 murQ 4.2.1.126 G Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HICBILPI_03750 1.6e-239 ybbF 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
HICBILPI_03751 5.8e-244 yfeW 3.4.16.4 V Belongs to the UPF0214 family
HICBILPI_03752 0.0 ybbD 3.2.1.52 G Belongs to the glycosyl hydrolase 3 family
HICBILPI_03753 1.2e-235 ybbC 3.2.1.52 S protein conserved in bacteria
HICBILPI_03754 1.3e-306 ybbB K COG2207 AraC-type DNA-binding domain-containing proteins
HICBILPI_03755 3.4e-172 feuA P Iron-uptake system-binding protein
HICBILPI_03756 8.1e-177 feuB P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HICBILPI_03757 6.1e-180 feuC P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HICBILPI_03758 1.9e-109 ybbA S Putative esterase
HICBILPI_03759 9.1e-173 ybaS 1.1.1.58 S Na -dependent transporter
HICBILPI_03760 1.3e-225 ybaR P COG0659 Sulfate permease and related transporters (MFS superfamily)
HICBILPI_03761 1.5e-202 1.1.1.14, 1.1.1.303, 1.1.1.4 E alcohol dehydrogenase
HICBILPI_03762 2.5e-175 suhB 3.1.3.25, 3.1.3.7 G inositol monophosphate 1-phosphatase activity
HICBILPI_03763 5.5e-247 dat 2.6.1.19 E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HICBILPI_03764 1.6e-219 glcP G Major Facilitator Superfamily
HICBILPI_03765 3.4e-39 S COG NOG14552 non supervised orthologous group
HICBILPI_03768 1.6e-08
HICBILPI_03771 3.4e-39 S COG NOG14552 non supervised orthologous group
HICBILPI_03772 2.1e-132 pdaB 3.5.1.104 G Polysaccharide deacetylase
HICBILPI_03773 9.1e-84 kbaA 2.7.8.43 S Involved in the activation of the KinB signaling pathway of sporulation
HICBILPI_03774 2.3e-11 kbaA 2.7.8.43 S Involved in the activation of the KinB signaling pathway of sporulation
HICBILPI_03775 1.7e-75 gerD
HICBILPI_03776 8.7e-198 mrp D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP
HICBILPI_03777 2.1e-134 cwlD 3.5.1.28 M n-acetylmuramoyl-L-alanine amidase
HICBILPI_03778 4.2e-77 ybaK S Protein of unknown function (DUF2521)
HICBILPI_03779 1.2e-82 yizA S Damage-inducible protein DinB
HICBILPI_03780 2.9e-142 ybaJ Q Methyltransferase domain
HICBILPI_03781 1.6e-64 rpsI J Belongs to the universal ribosomal protein uS9 family
HICBILPI_03782 1.9e-77 rplM J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HICBILPI_03783 2.6e-140 truA 5.4.99.12 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
HICBILPI_03784 9.1e-139 ecfT P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HICBILPI_03785 9.6e-150 ecfA2 3.6.3.55 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HICBILPI_03786 2.5e-155 cbiO P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HICBILPI_03787 4.7e-58 rplQ J Ribosomal protein L17
HICBILPI_03788 2.4e-170 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HICBILPI_03789 2.8e-64 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HICBILPI_03790 4e-57 rpsM J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HICBILPI_03791 4.2e-13 rpmJ J Belongs to the bacterial ribosomal protein bL36 family
HICBILPI_03792 1.1e-33 infA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HICBILPI_03793 4.1e-141 map 3.4.11.18 E Methionine aminopeptidase
HICBILPI_03794 2.6e-123 adk 2.7.4.3 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
HICBILPI_03795 3.9e-232 secY U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
HICBILPI_03796 1.3e-28 rplO J binds to the 23S rRNA
HICBILPI_03797 9.4e-20 rplO J binds to the 23S rRNA
HICBILPI_03798 1.9e-23 rpmD J Ribosomal protein L30
HICBILPI_03799 2.4e-84 rpsE J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HICBILPI_03800 1.2e-56 rplR J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HICBILPI_03801 7.9e-94 rplF J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HICBILPI_03802 2.3e-66 rpsH J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HICBILPI_03803 3.4e-28 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HICBILPI_03804 6e-94 rplE J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HICBILPI_03805 6.2e-51 rplX J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HICBILPI_03806 8.7e-60 rplN J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HICBILPI_03807 2.7e-39 rpsQ J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HICBILPI_03808 1.7e-25 rpmC J Belongs to the universal ribosomal protein uL29 family
HICBILPI_03809 1.3e-75 rplP J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HICBILPI_03810 8e-117 rpsC J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HICBILPI_03811 4.3e-53 rplV J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HICBILPI_03812 3.7e-47 rpsS J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HICBILPI_03813 1.5e-155 rplB J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HICBILPI_03814 1.2e-43 rplW J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
HICBILPI_03815 3e-105 rplD J Forms part of the polypeptide exit tunnel
HICBILPI_03816 6.3e-111 rplC J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HICBILPI_03817 7.5e-49 rpsJ J Involved in the binding of tRNA to the ribosomes
HICBILPI_03818 1.2e-182 ybaC 3.4.11.5 S Alpha/beta hydrolase family
HICBILPI_03819 1.8e-223 tuf J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HICBILPI_03820 0.0 fusA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HICBILPI_03821 7.9e-82 rpsG J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
HICBILPI_03822 6.5e-72 rpsL J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HICBILPI_03823 5.5e-34 ybxF J Belongs to the eukaryotic ribosomal protein eL8 family
HICBILPI_03824 0.0 rpoC 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HICBILPI_03825 0.0 rpoB 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HICBILPI_03826 1.8e-107 rsmC 2.1.1.172 J Methyltransferase
HICBILPI_03827 1.3e-42 rplL J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
HICBILPI_03828 5.1e-79 rplJ J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HICBILPI_03829 4.2e-124 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
HICBILPI_03830 2.8e-70 rplK J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HICBILPI_03831 3.2e-96 nusG K Participates in transcription elongation, termination and antitermination
HICBILPI_03832 7.8e-22 secE U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
HICBILPI_03833 8.9e-116 sigH K Belongs to the sigma-70 factor family
HICBILPI_03834 4.2e-89 yacP S RNA-binding protein containing a PIN domain
HICBILPI_03835 5.7e-135 trmH 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HICBILPI_03836 1e-72 mrnC J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HICBILPI_03837 5.3e-267 cysS 6.1.1.16, 6.3.1.13 J Belongs to the class-I aminoacyl-tRNA synthetase family
HICBILPI_03838 1.6e-117 cysE 2.3.1.30 E Serine acetyltransferase
HICBILPI_03839 5.3e-278 gltX 6.1.1.17, 6.1.1.24 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HICBILPI_03840 7e-86 ispF 2.1.1.228, 2.7.7.60, 4.6.1.12 I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)
HICBILPI_03841 4.2e-124 ispD 2.7.7.60, 4.6.1.12 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)
HICBILPI_03842 9.4e-195 yacL S COG4956 Integral membrane protein (PIN domain superfamily)
HICBILPI_03843 1.9e-195 disA 2.7.7.85 L Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HICBILPI_03844 1e-254 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HICBILPI_03845 1.2e-258 clpC O Belongs to the ClpA ClpB family
HICBILPI_03846 1.9e-153 clpC O Belongs to the ClpA ClpB family
HICBILPI_03847 1.9e-203 mcsB 2.7.14.1, 2.7.3.2, 2.7.3.3 E Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity
HICBILPI_03848 7.7e-63 mcsA 2.7.14.1 S protein with conserved CXXC pairs
HICBILPI_03849 7.5e-77 ctsR K Belongs to the CtsR family
HICBILPI_03850 3.4e-39 S COG NOG14552 non supervised orthologous group
HICBILPI_03855 2e-08
HICBILPI_03858 1.3e-07
HICBILPI_03860 3.4e-39 S COG NOG14552 non supervised orthologous group
HICBILPI_03861 8.4e-287 lysS 6.1.1.6 J Belongs to the class-II aminoacyl-tRNA synthetase family
HICBILPI_03862 1.7e-187 dus J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HICBILPI_03863 4.5e-29 yazB K transcriptional
HICBILPI_03864 2.4e-89 folK 1.13.11.81, 2.5.1.15, 2.7.6.3, 3.5.4.16, 4.1.2.25, 5.1.99.8 H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HICBILPI_03865 2.4e-62 folB 1.13.11.81, 2.5.1.15, 2.7.6.3, 4.1.2.25, 5.1.99.8 H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HICBILPI_03866 9.3e-80 folP 2.5.1.15, 2.7.6.3 H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HICBILPI_03867 5.9e-65 folP 2.5.1.15, 2.7.6.3 H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HICBILPI_03868 4.2e-161 pabC 2.6.1.42, 4.1.3.38 EH 4-amino-4-deoxychorismate lyase
HICBILPI_03869 2.6e-106 pabA 2.6.1.85, 4.1.3.27 EH Anthranilate synthase
HICBILPI_03870 2.3e-270 pabB 2.6.1.85 EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HICBILPI_03871 4.9e-168 cysK 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
HICBILPI_03872 3e-151 yacD 5.2.1.8 O peptidyl-prolyl isomerase
HICBILPI_03873 1.1e-161 hslO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HICBILPI_03874 3.1e-144 coaX 2.7.1.33 F Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HICBILPI_03875 0.0 ftsH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HICBILPI_03876 5.1e-93 hpt 2.4.2.8, 6.3.4.19 F Belongs to the purine pyrimidine phosphoribosyltransferase family
HICBILPI_03877 1.2e-271 tilS 2.4.2.8, 6.3.4.19 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
HICBILPI_03878 1.1e-60 KLT serine threonine protein kinase
HICBILPI_03879 3.4e-101 KLT serine threonine protein kinase
HICBILPI_03880 1.1e-122 yabS S protein containing a von Willebrand factor type A (vWA) domain
HICBILPI_03881 0.0 spoIIE 3.1.3.16, 3.1.3.3 KT stage II sporulation protein E
HICBILPI_03884 1.1e-57 yabR J RNA binding protein (contains ribosomal protein S1 domain)
HICBILPI_03885 4.1e-57 divIC D Septum formation initiator
HICBILPI_03886 2.9e-103 yabQ S spore cortex biosynthesis protein
HICBILPI_03887 1.9e-49 yabP S Sporulation protein YabP
HICBILPI_03888 2.8e-36 yabO J COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
HICBILPI_03889 8e-274 mazG 3.6.1.66, 3.6.1.9 S COG3956 Protein containing tetrapyrrole methyltransferase domain and MazG-like
HICBILPI_03890 2.3e-282 yabM S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
HICBILPI_03891 6.2e-91 spoVT K stage V sporulation protein
HICBILPI_03892 0.0 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HICBILPI_03893 3.7e-40 yabK S Peptide ABC transporter permease
HICBILPI_03894 4.2e-106 pth 3.1.1.29 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
HICBILPI_03895 3.8e-105 ctc J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HICBILPI_03896 9.4e-175 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HICBILPI_03897 9.2e-248 glmU 2.3.1.157, 2.7.7.23 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HICBILPI_03898 1.8e-47 spoVG D Essential for sporulation. Interferes with or is a negative regulator of the pathway leading to asymmetric septation
HICBILPI_03899 5.1e-63 yabJ 3.5.99.10 J translation initiation inhibitor, yjgF family
HICBILPI_03900 1.6e-152 purR 2.4.2.22, 2.4.2.7 F pur operon repressor
HICBILPI_03901 3.5e-160 ispE 2.1.1.182, 2.7.1.148 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HICBILPI_03902 2.9e-27 sspF S DNA topological change
HICBILPI_03903 7.8e-39 veg S protein conserved in bacteria
HICBILPI_03904 8.4e-146 yabG S peptidase
HICBILPI_03905 3e-159 ksgA 2.1.1.182 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
HICBILPI_03906 2.1e-97 rnmV 3.1.26.8 J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HICBILPI_03907 2.7e-231 rpfB GH23 T protein conserved in bacteria
HICBILPI_03908 4.5e-143 tatD L hydrolase, TatD
HICBILPI_03909 0.0 metG 6.1.1.10, 6.1.1.20 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HICBILPI_03910 8.8e-44 abrB K COG2002 Regulators of stationary sporulation gene expression
HICBILPI_03911 1.4e-161 rsmI 2.1.1.198 H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HICBILPI_03912 5.2e-47 yazA L endonuclease containing a URI domain
HICBILPI_03913 1.9e-138 yabB 2.1.1.223 S Conserved hypothetical protein 95
HICBILPI_03914 7.7e-37 yabA L Involved in initiation control of chromosome replication
HICBILPI_03915 8.8e-145 yaaT S stage 0 sporulation protein
HICBILPI_03916 1.3e-182 holB 2.7.7.7 L DNA polymerase III
HICBILPI_03917 1.2e-71 yaaR S protein conserved in bacteria
HICBILPI_03918 7.5e-55 yaaQ S protein conserved in bacteria
HICBILPI_03919 7.6e-112 tmk 2.7.4.9 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HICBILPI_03920 6.4e-268 adiA 4.1.1.17, 4.1.1.18, 4.1.1.19 E Orn Lys Arg decarboxylase
HICBILPI_03921 4.3e-187 yaaN P Belongs to the TelA family
HICBILPI_03922 3.3e-104 xpaC S 5-bromo-4-chloroindolyl phosphate hydrolysis protein
HICBILPI_03923 3.8e-30 csfB S Inhibitor of sigma-G Gin
HICBILPI_03926 3.4e-39 S COG NOG14552 non supervised orthologous group
HICBILPI_03927 3.2e-18 bofA S Sigma-K factor-processing regulatory protein BofA
HICBILPI_03928 3.6e-32 yaaL S Protein of unknown function (DUF2508)
HICBILPI_03929 2.3e-110 recR L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HICBILPI_03930 1e-35 yaaK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HICBILPI_03931 1.1e-127 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HICBILPI_03932 2.5e-178 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HICBILPI_03933 3.3e-18 tadA 3.5.4.1, 3.5.4.33 FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
HICBILPI_03934 1.2e-52 tadA 3.5.4.1, 3.5.4.33 FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
HICBILPI_03935 1.8e-98 yaaI Q COG1335 Amidases related to nicotinamidase
HICBILPI_03936 3.8e-211 yaaH M Glycoside Hydrolase Family
HICBILPI_03937 1.6e-114 dgk 2.7.1.113, 2.7.1.74, 2.7.1.76 F Deoxyguanosine kinase
HICBILPI_03938 4.5e-120 dck 2.7.1.113, 2.7.1.74, 2.7.1.76 F Deoxycytidine kinase
HICBILPI_03939 1.3e-09
HICBILPI_03940 1.3e-199 glxK 2.7.1.165 G Belongs to the glycerate kinase type-1 family
HICBILPI_03941 1.1e-205 serS 6.1.1.11 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HICBILPI_03942 2.8e-108 pdxT 4.3.3.6 H Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HICBILPI_03943 5.7e-158 pdxS 4.3.3.6 H Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HICBILPI_03944 2.3e-248 dacA 3.4.16.4 M Belongs to the peptidase S11 family
HICBILPI_03945 1.8e-273 guaB 1.1.1.205 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
HICBILPI_03946 7e-181 yaaC S YaaC-like Protein
HICBILPI_03949 3.4e-39 S COG NOG14552 non supervised orthologous group
HICBILPI_03950 2e-301 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HICBILPI_03951 6.2e-100 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HICBILPI_03952 0.0 gyrB 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HICBILPI_03953 8.1e-38 yaaB S Domain of unknown function (DUF370)
HICBILPI_03954 1.6e-205 recF L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HICBILPI_03955 2.4e-33 yaaA S S4 domain
HICBILPI_03956 1.8e-204 dnaN 2.7.7.7 L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
HICBILPI_03957 1.5e-250 dnaA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HICBILPI_03958 5.2e-54 rnpA 3.1.26.5 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
HICBILPI_03959 1.9e-133 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HICBILPI_03960 1.3e-108 jag S single-stranded nucleic acid binding R3H
HICBILPI_03961 2e-250 mnmE S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HICBILPI_03962 0.0 gidA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
HICBILPI_03963 1.6e-126 rsmG 2.1.1.170 J Specifically methylates the N7 position of guanine in position 535 of 16S rRNA
HICBILPI_03964 1.3e-151 noc D Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage
HICBILPI_03965 9.2e-136 soj D COG1192 ATPases involved in chromosome partitioning
HICBILPI_03966 7.9e-149 spo0J K Belongs to the ParB family
HICBILPI_03967 6.2e-111 yyaC S Sporulation protein YyaC
HICBILPI_03968 1.2e-46 4.2.1.103 K FR47-like protein
HICBILPI_03969 2.4e-176 yyaD S Membrane
HICBILPI_03970 2.3e-33 yyzM S protein conserved in bacteria
HICBILPI_03971 0.0 yyaE C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HICBILPI_03972 2.6e-200 ychF J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
HICBILPI_03973 7.3e-46 rpsF J Binds together with S18 to 16S ribosomal RNA
HICBILPI_03974 3.8e-69 ssb L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
HICBILPI_03975 3e-37 rpsR J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HICBILPI_03976 2.4e-104 adaA 3.2.2.21 K Transcriptional regulator
HICBILPI_03977 4.6e-97 adaB 2.1.1.63, 3.2.2.21 L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HICBILPI_03978 2.7e-140 xth 3.1.11.2 L exodeoxyribonuclease III
HICBILPI_03979 2.6e-177 ccpB 3.5.1.4, 5.1.1.1 K Transcriptional regulator
HICBILPI_03980 9.9e-67 yyaH 4.4.1.5 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HICBILPI_03981 2.6e-247 ydjK G Sugar (and other) transporter
HICBILPI_03982 1.9e-161 yyaK S CAAX protease self-immunity
HICBILPI_03983 0.0 yyaL O COG1331 Highly conserved protein containing a thioredoxin domain
HICBILPI_03984 2.7e-40 qacC U Small Multidrug Resistance protein
HICBILPI_03985 7.6e-14 yvaO K Transcriptional
HICBILPI_03986 3.3e-78 K Transcriptional regulator
HICBILPI_03987 1.5e-96 azoR I Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HICBILPI_03988 2.6e-129 ydfC EG EamA-like transporter family
HICBILPI_03989 7.2e-251 ydfD K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
HICBILPI_03990 8.5e-70 isp O Belongs to the peptidase S8 family
HICBILPI_03991 4.2e-19
HICBILPI_03992 4.5e-66 S Leucine-rich repeat (LRR) protein
HICBILPI_03993 3.6e-94
HICBILPI_03994 1.9e-136 IQ Catalyzes the formation of acetoacetate from 3-hydroxybutyrate
HICBILPI_03995 4.3e-161 K Transcriptional regulator
HICBILPI_03996 5.2e-66 4.1.1.44 S Carboxymuconolactone decarboxylase family
HICBILPI_03997 6.4e-162 eaeH M Domain of Unknown Function (DUF1259)
HICBILPI_03998 5.7e-46 yjcF S Acetyltransferase (GNAT) domain
HICBILPI_03999 1.6e-76 yybA 2.3.1.57 K transcriptional
HICBILPI_04000 1.5e-150 yqfU S Uncharacterized protein conserved in bacteria (DUF2179)
HICBILPI_04001 4.1e-69 ydgJ K Winged helix DNA-binding domain
HICBILPI_04002 5.6e-115 drgA C nitroreductase
HICBILPI_04003 2.2e-55 ypaA S Protein of unknown function (DUF1304)
HICBILPI_04004 3.2e-159 G Major Facilitator Superfamily
HICBILPI_04005 6.3e-77 dinB S PFAM DinB family protein
HICBILPI_04006 2.2e-114 K FCD domain
HICBILPI_04007 2.1e-311 levB 3.2.1.26, 3.2.1.64, 3.2.1.65 GH32 G Belongs to the glycosyl hydrolase 32 family
HICBILPI_04008 1.6e-261 sacB 2.4.1.10 GH68 M levansucrase activity
HICBILPI_04009 3e-148 yicL EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
HICBILPI_04010 1.7e-165 ppaC 3.6.1.1 C Inorganic pyrophosphatase
HICBILPI_04011 8.2e-66 ydeP3 K Transcriptional regulator
HICBILPI_04012 2.1e-83 cotF M Spore coat protein
HICBILPI_04014 2.4e-159 yybS S membrane
HICBILPI_04015 0.0 yybT T signaling protein consisting of a modified GGDEF domain and a DHH domain
HICBILPI_04016 4.9e-73 rplI J binds to the 23S rRNA
HICBILPI_04017 6.4e-122 KLT COG0515 Serine threonine protein kinase
HICBILPI_04018 4.9e-122 S GlcNAc-PI de-N-acetylase
HICBILPI_04019 3.6e-241 M Glycosyltransferase Family 4
HICBILPI_04020 2.5e-233 S Carbamoyl-phosphate synthase L chain, ATP binding domain
HICBILPI_04021 2.6e-202 S Ecdysteroid kinase
HICBILPI_04022 6.4e-235 M Glycosyltransferase Family 4
HICBILPI_04023 4.6e-17 yycC K YycC-like protein
HICBILPI_04025 5.7e-26 yycD S Uncharacterized protein conserved in bacteria (DUF2188)
HICBILPI_04026 3e-251 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
HICBILPI_04027 8.5e-72 yycE 3.4.21.26, 5.3.1.24 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HICBILPI_04028 1.7e-248 purA 6.3.4.4 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HICBILPI_04033 1.1e-132 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HICBILPI_04034 0.0 vicK 2.7.13.3 T Histidine kinase
HICBILPI_04035 2.5e-261 yycH S protein conserved in bacteria
HICBILPI_04036 1.1e-150 yycI S protein conserved in bacteria
HICBILPI_04037 3.9e-150 vicX 3.1.26.11 S COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I
HICBILPI_04038 3e-218 htrA 3.4.21.107 O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HICBILPI_04039 2.8e-10 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HICBILPI_04040 1.5e-248 phoR3 2.7.13.3 T COG0642 Signal transduction histidine kinase
HICBILPI_04041 1e-187 2.7.7.73, 2.7.7.80 H ThiF family
HICBILPI_04042 6.1e-257
HICBILPI_04043 4.5e-195 S Major Facilitator Superfamily
HICBILPI_04044 1.3e-304 S ABC transporter
HICBILPI_04045 5.9e-145 1.14.11.27 P peptidyl-arginine hydroxylation
HICBILPI_04046 7.7e-258 rocR KT COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains
HICBILPI_04047 5.1e-234 rocD 2.6.1.11, 2.6.1.13, 2.6.1.17 E Catalyzes the interconversion of ornithine to glutamate semialdehyde
HICBILPI_04048 1.1e-256 rocE E amino acid
HICBILPI_04049 4e-167 rocF 3.5.3.1, 3.5.3.11 E Belongs to the arginase family
HICBILPI_04050 1.1e-198 S Histidine kinase
HICBILPI_04052 1.4e-86 yycN 2.3.1.128 K Acetyltransferase
HICBILPI_04053 1.5e-183 C oxidoreductases (related to aryl-alcohol dehydrogenases)
HICBILPI_04054 4.5e-132 yycO S Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HICBILPI_04055 4.6e-216 yycP
HICBILPI_04057 7.9e-08 S YyzF-like protein
HICBILPI_04058 2e-80 rlmH 2.1.1.177 J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HICBILPI_04059 2.4e-108 mjecl24 D Involved in chromosome partitioning
HICBILPI_04060 4.1e-223
HICBILPI_04061 3.6e-20
HICBILPI_04062 2.7e-17
HICBILPI_04063 1.8e-176 S Fusaric acid resistance protein-like
HICBILPI_04064 5.3e-156 pucA 1.17.1.4 O COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HICBILPI_04065 4.6e-90 pucB 1.1.1.328, 1.17.1.4, 2.7.7.76 S MobA-like NTP transferase domain
HICBILPI_04066 0.0 C COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs
HICBILPI_04067 1.4e-55 C COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs
HICBILPI_04068 1.2e-154 1.2.5.3 C COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM CutM homologs
HICBILPI_04069 1.2e-82 pucE 1.2.5.3, 1.3.99.16 C COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs
HICBILPI_04070 1.1e-118 fbp 3.1.3.11 G Firmicute fructose-1,6-bisphosphatase
HICBILPI_04071 1e-226 fbp 3.1.3.11 G Firmicute fructose-1,6-bisphosphatase
HICBILPI_04072 9.3e-245 aapA E COG1113 Gamma-aminobutyrate permease and related permeases
HICBILPI_04073 2.3e-287 ahpF O Alkyl hydroperoxide reductase
HICBILPI_04074 3.2e-106 ahpC 1.11.1.15 O Alkyl hydroperoxide reductase
HICBILPI_04075 1.7e-125 E Ring-cleavage extradiol dioxygenase
HICBILPI_04076 3.8e-73 yxaI S membrane protein domain
HICBILPI_04077 2.9e-202 EGP Major facilitator Superfamily
HICBILPI_04078 7.8e-51 arsR3 K helix_turn_helix, Arsenical Resistance Operon Repressor
HICBILPI_04079 1.7e-64 S Family of unknown function (DUF5391)
HICBILPI_04080 2.8e-142 S PQQ-like domain
HICBILPI_04081 3.6e-249 alkH 1.2.1.3 C Belongs to the aldehyde dehydrogenase family
HICBILPI_04082 6.2e-213 yxbF K Bacterial regulatory proteins, tetR family
HICBILPI_04083 1.8e-198 des 1.14.19.23, 1.14.19.45 I fatty acid desaturase
HICBILPI_04084 4.5e-200 desK 2.7.13.3 T Histidine kinase
HICBILPI_04085 1e-102 desR T COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HICBILPI_04086 4.1e-150 IQ Enoyl-(Acyl carrier protein) reductase
HICBILPI_04088 0.0 htpG O Molecular chaperone. Has ATPase activity
HICBILPI_04089 4.3e-245 csbC EGP Major facilitator Superfamily
HICBILPI_04090 4.6e-174 iolS C Aldo keto reductase
HICBILPI_04091 2e-135 iolR K COG1349 Transcriptional regulators of sugar metabolism
HICBILPI_04092 4.8e-279 iolA 1.2.1.18, 1.2.1.27 C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
HICBILPI_04093 3.5e-154 iolB 5.3.1.30 G Involved in the isomerization of 5-deoxy-glucuronate (5DG) to 5-dehydro-2-deoxy-D-gluconate (DKG or 2-deoxy-5-keto-D- gluconate)
HICBILPI_04094 2.7e-180 iolC 2.7.1.92 G Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D- gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5- dehydro-2-deoxy-D-gluconate (DKGP)
HICBILPI_04095 0.0 iolD 3.7.1.22 E Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG)
HICBILPI_04096 3.4e-174 iolE 4.2.1.44 H Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol)
HICBILPI_04097 6.7e-232 iolF EGP Major facilitator Superfamily
HICBILPI_04098 2e-194 iolG 1.1.1.18, 1.1.1.369 S Involved in the oxidation of myo-inositol (MI) and D- chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively
HICBILPI_04099 3.3e-166 iolH G Xylose isomerase-like TIM barrel
HICBILPI_04100 2.5e-147 iolI 5.3.99.11 G Involved in the reversible interconverion of 2-keto-myo- inositol (2KMI, inosose or 2,4,6 3,5-pentahydroxycyclohexanone) to 1-keto-D-chiro-inositol (1KDCI or 2,3,5 4,6- pentahydroxycyclohexanone)
HICBILPI_04101 1.8e-156 iolJ 4.1.2.13, 4.1.2.29 F Produces dihydroxyacetone phosphate (DHAP or glycerone phosphate) and malonic semialdehyde (MSA or 3-oxopropanoate) from 6-phospho-5-dehydro-2-deoxy-D-gluconate (DKGP)
HICBILPI_04102 1.6e-123 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HICBILPI_04103 2.5e-175 T PhoQ Sensor
HICBILPI_04104 3.6e-140 yxdL V ABC transporter, ATP-binding protein
HICBILPI_04105 0.0 yxdM V ABC transporter (permease)
HICBILPI_04106 1.3e-57 yxeA S Protein of unknown function (DUF1093)
HICBILPI_04107 4.1e-178 fhuD P Periplasmic binding protein
HICBILPI_04108 1.3e-34
HICBILPI_04109 3.4e-17 yxeD
HICBILPI_04113 2.6e-149 yidA S hydrolases of the HAD superfamily
HICBILPI_04114 9.6e-172 deoR K COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain
HICBILPI_04115 3.6e-112 deoC 4.1.2.4 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HICBILPI_04116 6.8e-207 nupC F Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HICBILPI_04117 2.3e-232 pdp 2.4.2.2, 2.4.2.4 F phosphorylase
HICBILPI_04118 4.4e-253 lysP E amino acid
HICBILPI_04119 9.4e-175 hutG 3.5.3.11, 3.5.3.8 E Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide
HICBILPI_04120 6.3e-235 hutI 3.5.2.7 Q Imidazolone-5-propionate hydrolase
HICBILPI_04121 0.0 hutU 4.2.1.49 E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HICBILPI_04122 1.1e-284 hutH 4.3.1.3 E Histidine ammonia-lyase
HICBILPI_04123 7.7e-79 hutP K Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization
HICBILPI_04124 2.6e-274 yxiA 3.2.1.99 GH43 G Belongs to the glycosyl hydrolase 43 family
HICBILPI_04125 9.5e-65 nudG 3.6.1.55, 3.6.1.65 L COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
HICBILPI_04126 0.0 L HKD family nuclease
HICBILPI_04127 1.8e-72 yxiE T Belongs to the universal stress protein A family
HICBILPI_04128 3.6e-147 yxxF EG EamA-like transporter family
HICBILPI_04129 5.5e-200 pelB 4.2.2.10, 4.2.2.2 G Pectate lyase
HICBILPI_04130 0.0 wapA M COG3209 Rhs family protein
HICBILPI_04131 9.3e-88
HICBILPI_04135 3.2e-110
HICBILPI_04136 3.7e-13 S YxiJ-like protein
HICBILPI_04137 2.8e-20
HICBILPI_04139 2e-261 dbpA 3.6.4.13 JKL DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes
HICBILPI_04140 4.3e-220 yxiO S COG2270 Permeases of the major facilitator superfamily
HICBILPI_04141 2.7e-20 licT K transcriptional antiterminator
HICBILPI_04142 2.3e-70 licT K transcriptional antiterminator
HICBILPI_04144 2e-140 exoK GH16 M licheninase activity
HICBILPI_04145 1.4e-221 citH C Citrate transporter
HICBILPI_04146 0.0 katE 1.11.1.6, 3.5.1.124 P serves to protect cells from the toxic effects of hydrogen peroxide
HICBILPI_04147 1.5e-49 yxiS
HICBILPI_04148 6.5e-57 T Domain of unknown function (DUF4163)
HICBILPI_04149 1.7e-152 nupG F Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HICBILPI_04150 1.5e-41 nupG F Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HICBILPI_04151 6.2e-09 S Macro domain
HICBILPI_04152 2.8e-14 S Macro domain
HICBILPI_04155 3e-24 S Domain of unknown function (DUF4062)
HICBILPI_04162 3.9e-50 U Protein of unknown function DUF262
HICBILPI_04166 1.3e-09 snf 2.7.11.1 L snf2 family
HICBILPI_04168 6.7e-42 ddpX 3.4.13.22 S Protein conserved in bacteria
HICBILPI_04170 1e-10 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
HICBILPI_04174 1e-06 V COG1403 Restriction endonuclease
HICBILPI_04180 1.2e-48 yokF 3.1.31.1 L RNA catabolic process
HICBILPI_04183 2.8e-08
HICBILPI_04187 4.2e-09
HICBILPI_04194 2.7e-62 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HICBILPI_04198 1e-19 sasP S spore protein
HICBILPI_04200 4.3e-105 2.1.1.37 L DNA (cytosine-5-)-methyltransferase activity
HICBILPI_04202 1.3e-42 rtp K Plays a role in DNA replication and termination (fork arrest mechanism). Two dimers of rtp bind to the two inverted repeat regions (IRI and IRII) present in the termination site. The binding of each dimer is centered on an 8 bp direct repeat
HICBILPI_04207 2e-10
HICBILPI_04208 6.4e-39 yvrI K COG1191 DNA-directed RNA polymerase specialized sigma subunit
HICBILPI_04209 5.3e-08 S YvrJ protein family
HICBILPI_04211 6.3e-46
HICBILPI_04220 9.6e-39 pilT-1 NU Type II/IV secretion system protein
HICBILPI_04233 8.1e-51 soj D COG1192 ATPases involved in chromosome partitioning
HICBILPI_04236 5.8e-07 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
HICBILPI_04239 8.8e-56 ypuA S Protein of unknown function (DUF1002)
HICBILPI_04242 5.4e-14 S metallopeptidase activity
HICBILPI_04261 7.3e-17
HICBILPI_04266 1e-07 L AAA domain
HICBILPI_04269 2.4e-37 rlmI 2.1.1.191, 2.1.1.72 L DNA methylase
HICBILPI_04278 1.1e-57 3.6.4.12 L UvrD-like helicase C-terminal domain
HICBILPI_04282 4.4e-22 recJ L single-stranded DNA 5'-3' exodeoxyribonuclease activity
HICBILPI_04292 4.7e-08
HICBILPI_04297 6.3e-218 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HICBILPI_04299 1.5e-11
HICBILPI_04300 3.9e-07
HICBILPI_04305 9.4e-27
HICBILPI_04318 7e-09
HICBILPI_04321 1.2e-18
HICBILPI_04325 2.3e-15 H ThiF family
HICBILPI_04329 1.6e-72 ddpX 3.4.13.22, 6.1.1.12 F protein conserved in bacteria
HICBILPI_04330 2.3e-91 S Predicted nucleotidyltransferase
HICBILPI_04332 4.2e-32 3.5.1.28 MNU Lysozyme subfamily 2
HICBILPI_04333 3.9e-14 S 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
HICBILPI_04335 6.9e-16
HICBILPI_04343 8.2e-07 3.4.21.88 K Transcriptional
HICBILPI_04344 1.1e-81 S Protein of unknown function (DUF1273)
HICBILPI_04346 2.5e-175 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HICBILPI_04348 1.6e-47 S Chaperone for flagella basal body P-ring formation
HICBILPI_04349 7.7e-86 D bacterial-type flagellum organization
HICBILPI_04350 1.3e-138 U COG4962 Flp pilus assembly protein, ATPase CpaF
HICBILPI_04351 2.4e-43 NU Type II secretion system (T2SS), protein F
HICBILPI_04352 1.7e-37
HICBILPI_04355 1.5e-20
HICBILPI_04356 1.5e-25 M heme binding
HICBILPI_04358 3.2e-27 N Pkd domain containing protein
HICBILPI_04362 4.3e-53 gspE NU type II secretion system protein E
HICBILPI_04364 2.1e-10 S NrdI Flavodoxin like
HICBILPI_04365 3e-144 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HICBILPI_04366 3.9e-33 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HICBILPI_04367 3.2e-33 ymaB S DNA mismatch repair protein MutT
HICBILPI_04369 1.5e-23 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HICBILPI_04374 5.4e-27 S Mitochondrial biogenesis AIM24
HICBILPI_04382 5.3e-13 POL1A 2.7.7.7 L plastid DNA replication
HICBILPI_04385 9.9e-39 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HICBILPI_04393 1.8e-20 usp CBM50 M protein conserved in bacteria
HICBILPI_04394 8.3e-07 M Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
HICBILPI_04399 2e-07 D Cellulose biosynthesis protein BcsQ
HICBILPI_04401 1.3e-41 S AAA-like domain
HICBILPI_04406 8.2e-16 D DNA segregation ATPase FtsK SpoIIIE and related
HICBILPI_04422 5.5e-52 cbf L Shows a 3'-5' exoribonuclease activity
HICBILPI_04424 2.8e-21 S Uncharacterized protein conserved in bacteria (DUF2325)
HICBILPI_04429 8.5e-133 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HICBILPI_04437 9.7e-12
HICBILPI_04449 1.4e-20 S B-1 B cell differentiation
HICBILPI_04450 4.6e-146 J tRNA cytidylyltransferase activity
HICBILPI_04451 1.6e-54 S response regulator aspartate phosphatase
HICBILPI_04453 2.5e-113 L Belongs to the 'phage' integrase family
HICBILPI_04454 5e-62
HICBILPI_04457 2.9e-18
HICBILPI_04458 4.8e-39 S Macro domain
HICBILPI_04462 4.5e-36 S Domain of unknown function (DUF4062)
HICBILPI_04467 3.9e-50 U Protein of unknown function DUF262
HICBILPI_04471 1.3e-09 snf 2.7.11.1 L snf2 family
HICBILPI_04473 6.7e-42 ddpX 3.4.13.22 S Protein conserved in bacteria
HICBILPI_04476 1e-10 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication

eggNOG-mapper v2 (Database: eggNOG v5.0, Jul. 2018 release)