ORF_ID e_value Gene_name EC_number CAZy COGs Description
COHBPNKO_00001 2.1e-200 L Transposase
COHBPNKO_00002 2e-263 M ErfK YbiS YcfS YnhG
COHBPNKO_00003 1.2e-32 bamA GM domain, Protein
COHBPNKO_00004 9.3e-65 gntR1 K Transcriptional regulator, GntR family
COHBPNKO_00005 3.7e-154 V ABC transporter, ATP-binding protein
COHBPNKO_00006 6e-115
COHBPNKO_00007 8e-142 manA 1.14.13.81, 5.3.1.8, 5.4.2.8 G MucBP domain
COHBPNKO_00008 1.1e-99 S Pfam:DUF3816
COHBPNKO_00009 0.0 clpE O Belongs to the ClpA ClpB family
COHBPNKO_00010 2.9e-27
COHBPNKO_00011 2.7e-39 ptsH G phosphocarrier protein HPR
COHBPNKO_00012 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
COHBPNKO_00013 2.2e-200 L Transposase
COHBPNKO_00014 4.6e-88 pgpA 3.1.3.27 I Phosphatidylglycerophosphatase A
COHBPNKO_00015 2.6e-175 ABC-SBP S ABC transporter
COHBPNKO_00016 4.7e-88 rlmH 2.1.1.177 J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
COHBPNKO_00018 1.1e-95 S reductase
COHBPNKO_00019 1.9e-225 dhaT 1.1.1.1, 1.1.1.202 C Dehydrogenase
COHBPNKO_00020 1.1e-153 glcU U sugar transport
COHBPNKO_00021 9.4e-149 E Glyoxalase-like domain
COHBPNKO_00022 2.1e-146 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
COHBPNKO_00023 6.1e-260 gabD 1.2.1.16, 1.2.1.20, 1.2.1.79 C Belongs to the aldehyde dehydrogenase family
COHBPNKO_00024 4.4e-144 bacG M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
COHBPNKO_00025 3.7e-128 V ABC transporter
COHBPNKO_00026 3.1e-218 bacI V MacB-like periplasmic core domain
COHBPNKO_00027 1.8e-31
COHBPNKO_00028 3.1e-267 S Putative peptidoglycan binding domain
COHBPNKO_00030 3e-54 L An automated process has identified a potential problem with this gene model
COHBPNKO_00031 1.4e-84 K FR47-like protein
COHBPNKO_00032 3.2e-124 hisK 3.1.3.15 E Histidinol phosphatase and related hydrolases of the PHP family
COHBPNKO_00034 5.5e-74 osmC O OsmC-like protein
COHBPNKO_00035 2e-175 ldhD 1.1.1.28 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
COHBPNKO_00036 1e-218 patA 2.6.1.1 E Aminotransferase
COHBPNKO_00037 2.7e-32
COHBPNKO_00038 0.0 clpL O associated with various cellular activities
COHBPNKO_00040 2.1e-200 L Transposase
COHBPNKO_00041 0.0 ganB 3.2.1.89 G arabinogalactan
COHBPNKO_00043 1.7e-65 XK27_01125 L PFAM IS66 Orf2 family protein
COHBPNKO_00044 2.2e-200 L Transposase
COHBPNKO_00045 4.9e-160 rbsK 2.7.1.15 H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
COHBPNKO_00046 1.1e-184 rbsR K Periplasmic binding proteins and sugar binding domain of LacI family
COHBPNKO_00047 3.8e-113
COHBPNKO_00048 1.5e-115 dck 2.7.1.74 F deoxynucleoside kinase
COHBPNKO_00049 2.1e-180 NU Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
COHBPNKO_00050 1.9e-86 uspA T Belongs to the universal stress protein A family
COHBPNKO_00051 2.1e-276 pepV 3.5.1.18 E dipeptidase PepV
COHBPNKO_00052 3.7e-154 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
COHBPNKO_00053 1.5e-18 K Cro/C1-type HTH DNA-binding domain
COHBPNKO_00054 6.3e-69 epsIIL S Polysaccharide biosynthesis protein
COHBPNKO_00055 4.3e-39 2.4.1.166 GT2 M Glycosyltransferase like family 2
COHBPNKO_00056 7.3e-21 M Glycosyltransferase sugar-binding region containing DXD motif
COHBPNKO_00057 1.4e-25 M transferase activity, transferring glycosyl groups
COHBPNKO_00058 1.6e-21 S EpsG family
COHBPNKO_00059 1.4e-89 lsgF M Glycosyl transferase family 2
COHBPNKO_00060 1.1e-49 pglC M Bacterial sugar transferase
COHBPNKO_00061 2.2e-115 ywqD 2.7.10.1 D Capsular exopolysaccharide family
COHBPNKO_00062 3.1e-132 epsB M biosynthesis protein
COHBPNKO_00063 7.3e-162 brpA K Cell envelope-like function transcriptional attenuator common domain protein
COHBPNKO_00064 1.2e-67 K Transcriptional regulator, HxlR family
COHBPNKO_00065 9.4e-127
COHBPNKO_00066 8.4e-102 K DNA-templated transcription, initiation
COHBPNKO_00067 3.3e-36
COHBPNKO_00068 3.4e-83
COHBPNKO_00069 1.3e-290 glpK 2.7.1.30 F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
COHBPNKO_00070 1e-24 dmpI 5.3.2.6 G Belongs to the 4-oxalocrotonate tautomerase family
COHBPNKO_00071 0.0 yjbQ P TrkA C-terminal domain protein
COHBPNKO_00072 1.1e-269 pipD E Dipeptidase
COHBPNKO_00074 1.7e-44 gpsB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
COHBPNKO_00075 8.9e-104 ypsA S Belongs to the UPF0398 family
COHBPNKO_00076 1.3e-116 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
COHBPNKO_00077 0.0 ponA 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein 1A
COHBPNKO_00078 1.4e-162 EG EamA-like transporter family
COHBPNKO_00079 3.9e-125 dnaD L DnaD domain protein
COHBPNKO_00080 2.9e-85 ypmB S Protein conserved in bacteria
COHBPNKO_00081 0.0 dinG 2.7.7.7, 3.6.4.12 L helicase involved in DNA repair and perhaps also replication
COHBPNKO_00082 1.7e-171 mvk 1.1.1.88, 2.3.3.10, 2.7.1.36 I mevalonate kinase
COHBPNKO_00083 4.9e-163 mvaD 4.1.1.33 I diphosphomevalonate decarboxylase
COHBPNKO_00084 4.2e-214 mvaK2 2.7.1.36, 2.7.1.43, 2.7.4.2 I phosphomevalonate kinase
COHBPNKO_00085 1.7e-193 fni 1.1.1.88, 5.3.3.2 C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
COHBPNKO_00086 3.8e-87 S Protein of unknown function (DUF1440)
COHBPNKO_00087 0.0 rafA 3.2.1.22 G alpha-galactosidase
COHBPNKO_00088 1.4e-192 galR K Periplasmic binding protein-like domain
COHBPNKO_00089 4.2e-169 scrK 2.7.1.2, 2.7.1.4 GK ROK family
COHBPNKO_00090 6.4e-179 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
COHBPNKO_00091 2.6e-124 lrgB M LrgB-like family
COHBPNKO_00092 1.9e-66 lrgA S LrgA family
COHBPNKO_00093 1.1e-130 lytT K response regulator receiver
COHBPNKO_00094 0.0 lytS 2.7.13.3 T LytS YhcK-type transmembrane receptor domain protein
COHBPNKO_00095 4e-148 f42a O Band 7 protein
COHBPNKO_00096 4.2e-261 rsmF 2.1.1.176, 2.1.1.178 J NOL1 NOP2 sun family protein
COHBPNKO_00097 4.1e-155 yitU 3.1.3.104 S hydrolase
COHBPNKO_00098 9.2e-39 S Cytochrome B5
COHBPNKO_00099 1.2e-117 nreC K PFAM regulatory protein LuxR
COHBPNKO_00100 3.6e-160 hipB K Helix-turn-helix
COHBPNKO_00101 2.8e-57 yitW S Iron-sulfur cluster assembly protein
COHBPNKO_00102 4.2e-272 sufB O assembly protein SufB
COHBPNKO_00103 3.2e-80 nifU C SUF system FeS assembly protein, NifU family
COHBPNKO_00104 2.3e-234 sufS 2.8.1.7, 4.4.1.16 E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
COHBPNKO_00105 8.1e-238 sufD O FeS assembly protein SufD
COHBPNKO_00106 3.2e-144 sufC O FeS assembly ATPase SufC
COHBPNKO_00107 1.2e-31 feoA P FeoA domain
COHBPNKO_00108 0.0 feoB P transporter of a GTP-driven Fe(2 ) uptake system
COHBPNKO_00109 7e-223 L Transposase
COHBPNKO_00110 2.9e-218 L Transposase IS66 family
COHBPNKO_00111 5.4e-166 UW LPXTG-motif cell wall anchor domain protein
COHBPNKO_00112 0.0 UW LPXTG-motif cell wall anchor domain protein
COHBPNKO_00114 2.2e-154 metQ_4 P Belongs to the nlpA lipoprotein family
COHBPNKO_00115 7.4e-88 luxS 4.4.1.21 H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
COHBPNKO_00116 1.7e-125 O Zinc-dependent metalloprotease
COHBPNKO_00117 1.9e-115 S Membrane
COHBPNKO_00118 1.8e-198 adh 1.1.1.1, 1.1.1.14 E alcohol dehydrogenase
COHBPNKO_00119 4.7e-76 S Domain of unknown function (DUF4767)
COHBPNKO_00120 4.3e-13
COHBPNKO_00121 1.3e-208 cytX U Belongs to the purine-cytosine permease (2.A.39) family
COHBPNKO_00122 3.4e-94 wecD3 K PFAM GCN5-related N-acetyltransferase
COHBPNKO_00123 1.6e-79
COHBPNKO_00124 1.9e-120 M Lysin motif
COHBPNKO_00125 3.8e-194 EGP Major facilitator Superfamily
COHBPNKO_00126 2e-36 D Antitoxin component of a toxin-antitoxin (TA) module
COHBPNKO_00127 3.2e-53 S ParE toxin of type II toxin-antitoxin system, parDE
COHBPNKO_00128 6e-100 ywlG S Belongs to the UPF0340 family
COHBPNKO_00129 4.2e-101 gshF 6.3.2.2 H Belongs to the glutamate--cysteine ligase type 1 family
COHBPNKO_00130 4e-231 deoB 5.4.2.7 G Phosphotransfer between the C1 and C5 carbon atoms of pentose
COHBPNKO_00131 2.4e-138 pnuC H nicotinamide mononucleotide transporter
COHBPNKO_00132 8.7e-128 udp 2.4.2.1, 2.4.2.3 F Phosphorylase superfamily
COHBPNKO_00133 5.9e-99 crp_2 K Cyclic nucleotide-binding domain
COHBPNKO_00134 1.9e-126 S PFAM Archaeal ATPase
COHBPNKO_00135 8.6e-159 spoU 2.1.1.185 J Methyltransferase
COHBPNKO_00136 4.4e-133 oxlT P Major Facilitator Superfamily
COHBPNKO_00137 9.6e-302 guaA 2.3.1.128, 6.3.5.2 F Catalyzes the synthesis of GMP from XMP
COHBPNKO_00139 2.2e-221 S cog cog1373
COHBPNKO_00140 1.3e-176 coaA 2.7.1.33 F Pantothenic acid kinase
COHBPNKO_00141 0.0 ltaS 2.7.8.20 M Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
COHBPNKO_00142 6e-160 EG EamA-like transporter family
COHBPNKO_00143 4.5e-255 nox C NADH oxidase
COHBPNKO_00144 3.3e-242 nox C NADH oxidase
COHBPNKO_00145 0.0 helD 3.6.4.12 L DNA helicase
COHBPNKO_00146 9.7e-115 dedA S SNARE associated Golgi protein
COHBPNKO_00147 7.2e-126 3.1.3.73 G phosphoglycerate mutase
COHBPNKO_00148 8.3e-227 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
COHBPNKO_00149 6.9e-10
COHBPNKO_00150 2e-31 S Transglycosylase associated protein
COHBPNKO_00152 5.9e-180 1.1.1.28 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
COHBPNKO_00153 4.3e-199 V domain protein
COHBPNKO_00154 1.6e-94 K Transcriptional regulator (TetR family)
COHBPNKO_00155 4.4e-39 pspC KT PspC domain protein
COHBPNKO_00156 4.9e-151
COHBPNKO_00157 1.2e-16 3.2.1.14 GH18
COHBPNKO_00158 1.5e-82 zur P Belongs to the Fur family
COHBPNKO_00159 5.8e-103 gmk2 2.7.4.8 F Guanylate kinase
COHBPNKO_00160 3.4e-73 apfA 2.7.7.72, 3.6.1.61 F Nudix hydrolase
COHBPNKO_00161 1e-254 yfnA E Amino Acid
COHBPNKO_00162 4.2e-234 EGP Sugar (and other) transporter
COHBPNKO_00163 5.4e-67 XK27_01125 L PFAM IS66 Orf2 family protein
COHBPNKO_00165 1.7e-165 glsA 3.5.1.2 E Belongs to the glutaminase family
COHBPNKO_00166 1.4e-253 dltD M Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
COHBPNKO_00167 1.7e-35 dltC 6.1.1.13 J Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
COHBPNKO_00168 1.9e-233 dltB M MBOAT, membrane-bound O-acyltransferase family
COHBPNKO_00169 7.7e-296 dltA 6.1.1.13 H Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
COHBPNKO_00171 2.2e-60 acpS 2.7.6.3, 2.7.8.7, 5.1.1.1 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
COHBPNKO_00172 1.1e-209 alr 5.1.1.1 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
COHBPNKO_00173 3.2e-62 L Toxic component of a toxin-antitoxin (TA) module
COHBPNKO_00174 9.8e-250 U Belongs to the purine-cytosine permease (2.A.39) family
COHBPNKO_00175 6.1e-243 codA 3.5.4.1 F cytosine deaminase
COHBPNKO_00176 3.1e-147 tesE Q hydratase
COHBPNKO_00177 1.8e-113 S (CBS) domain
COHBPNKO_00178 1.1e-103 pth 3.1.1.29 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
COHBPNKO_00179 0.0 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
COHBPNKO_00180 2.1e-39 yabO J S4 domain protein
COHBPNKO_00181 5.6e-56 divIC D Septum formation initiator
COHBPNKO_00182 9.8e-67 yabR J RNA binding
COHBPNKO_00183 2.7e-263 tilS 2.4.2.8, 6.3.4.19 J Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
COHBPNKO_00184 1.5e-97 hpt 2.4.2.8 F Belongs to the purine pyrimidine phosphoribosyltransferase family
COHBPNKO_00185 0.0 ftsH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
COHBPNKO_00186 5.2e-170 hslO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
COHBPNKO_00187 2.2e-190 dus J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
COHBPNKO_00188 3e-292 lysS 6.1.1.6 J Belongs to the class-II aminoacyl-tRNA synthetase family
COHBPNKO_00189 5.4e-67 XK27_01125 L PFAM IS66 Orf2 family protein
COHBPNKO_00192 2.8e-19
COHBPNKO_00193 1.3e-263 dtpT U amino acid peptide transporter
COHBPNKO_00194 3.5e-157 yjjH S Calcineurin-like phosphoesterase
COHBPNKO_00197 7.4e-115
COHBPNKO_00198 7.7e-250 EGP Major facilitator Superfamily
COHBPNKO_00199 2.9e-108 aspT P Predicted Permease Membrane Region
COHBPNKO_00200 4e-159 aspT P Predicted Permease Membrane Region
COHBPNKO_00201 2.4e-130 racD 5.1.1.13 M Belongs to the aspartate glutamate racemases family
COHBPNKO_00202 1.8e-127 gntR1 K UbiC transcription regulator-associated domain protein
COHBPNKO_00203 1.7e-284 pncB 6.3.4.21 F Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
COHBPNKO_00204 9.7e-152 nadE 6.3.1.5 F Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
COHBPNKO_00205 0.0 yhgF K Tex-like protein N-terminal domain protein
COHBPNKO_00206 3.3e-85 ydcK S Belongs to the SprT family
COHBPNKO_00208 0.0 lacL 3.2.1.23 G Belongs to the glycosyl hydrolase 2 family
COHBPNKO_00209 5.9e-185 lacM 3.2.1.23, 3.2.1.35, 3.2.1.51, 3.2.1.97 GH101,GH29 G beta-galactosidase
COHBPNKO_00210 0.0 S Bacterial membrane protein, YfhO
COHBPNKO_00211 1.6e-134 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
COHBPNKO_00212 3.1e-169 I alpha/beta hydrolase fold
COHBPNKO_00213 1.7e-215 metC 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
COHBPNKO_00214 1.1e-119 tcyB E ABC transporter
COHBPNKO_00215 4.4e-135 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
COHBPNKO_00216 2.1e-140 tcyA ET Belongs to the bacterial solute-binding protein 3 family
COHBPNKO_00217 3.9e-267 pepC 3.4.22.40 E Peptidase C1-like family
COHBPNKO_00218 2.6e-126 rpiA 2.7.1.12, 5.3.1.6 G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
COHBPNKO_00219 3.2e-49 HA62_12640 S GCN5-related N-acetyl-transferase
COHBPNKO_00220 1.4e-98 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F dUTP diphosphatase
COHBPNKO_00221 1.6e-255 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
COHBPNKO_00222 5e-207 yacL S domain protein
COHBPNKO_00223 1.3e-273 cysS 6.1.1.16, 6.3.1.13 J Belongs to the class-I aminoacyl-tRNA synthetase family
COHBPNKO_00224 7.2e-71 mrnC J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
COHBPNKO_00225 4.7e-137 rlmB 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
COHBPNKO_00226 1.4e-21 rpmG J Belongs to the bacterial ribosomal protein bL33 family
COHBPNKO_00227 1.4e-15 secE U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
COHBPNKO_00228 3.4e-97 nusG K Participates in transcription elongation, termination and antitermination
COHBPNKO_00229 3.7e-70 rplK J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
COHBPNKO_00230 3e-122 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
COHBPNKO_00231 4.6e-227 aadAT EK Aminotransferase, class I
COHBPNKO_00233 4e-245 M Glycosyl transferase family group 2
COHBPNKO_00234 1.2e-208 mnaA 5.1.3.14 G Belongs to the UDP-N-acetylglucosamine 2-epimerase family
COHBPNKO_00235 1.7e-82 rplJ J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
COHBPNKO_00236 3.2e-54 rplL J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
COHBPNKO_00237 7.7e-48
COHBPNKO_00239 7.7e-40 mscL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
COHBPNKO_00240 2.4e-56 K transcriptional regulator PadR family
COHBPNKO_00241 2.5e-80 XK27_06920 S Protein of unknown function (DUF1700)
COHBPNKO_00242 4.6e-132 S Putative adhesin
COHBPNKO_00243 0.0 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
COHBPNKO_00244 2.2e-198 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
COHBPNKO_00245 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
COHBPNKO_00246 3.4e-35 nrdH O Glutaredoxin
COHBPNKO_00247 3.5e-91 tadA 3.5.4.33 F Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
COHBPNKO_00248 1.5e-301 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
COHBPNKO_00249 7e-47 yaaK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
COHBPNKO_00250 3.3e-109 recR L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
COHBPNKO_00251 9.7e-39 S Protein of unknown function (DUF2508)
COHBPNKO_00252 1.1e-115 tmk 2.7.4.9 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
COHBPNKO_00253 7.6e-52 yaaQ S Cyclic-di-AMP receptor
COHBPNKO_00254 3.1e-184 holB 2.7.7.7 L DNA polymerase III
COHBPNKO_00255 5.9e-58 yabA L Involved in initiation control of chromosome replication
COHBPNKO_00256 1.2e-155 rsmI 2.1.1.198 H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
COHBPNKO_00257 1.2e-135 fat 3.1.2.21 I Acyl-ACP thioesterase
COHBPNKO_00258 5.4e-67 XK27_01125 L PFAM IS66 Orf2 family protein
COHBPNKO_00260 1.1e-29
COHBPNKO_00261 1.6e-29
COHBPNKO_00262 1.9e-255 ytgP S Polysaccharide biosynthesis protein
COHBPNKO_00263 1.4e-40
COHBPNKO_00264 0.0 leuS 6.1.1.4 J Belongs to the class-I aminoacyl-tRNA synthetase family
COHBPNKO_00265 1.9e-217 metK 2.5.1.6 H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
COHBPNKO_00266 3.4e-97 tag 3.2.2.20 L glycosylase
COHBPNKO_00267 2.4e-259 EGP Major facilitator Superfamily
COHBPNKO_00268 4.3e-85 perR P Belongs to the Fur family
COHBPNKO_00269 5.3e-232 cycA E Amino acid permease
COHBPNKO_00270 4.4e-103 V VanZ like family
COHBPNKO_00271 1e-23
COHBPNKO_00272 7.7e-86 S Short repeat of unknown function (DUF308)
COHBPNKO_00273 1.5e-79 S Psort location Cytoplasmic, score
COHBPNKO_00274 5.6e-283 dinB 2.7.7.7 L impB/mucB/samB family C-terminal domain
COHBPNKO_00275 1.4e-172 L transposase, IS605 OrfB family
COHBPNKO_00276 2.4e-77 hsp O Belongs to the small heat shock protein (HSP20) family
COHBPNKO_00277 1.2e-152 yeaE S Aldo keto
COHBPNKO_00278 7e-223 L Transposase
COHBPNKO_00279 1.7e-65 XK27_01125 L PFAM IS66 Orf2 family protein
COHBPNKO_00281 3.2e-121 mecA NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
COHBPNKO_00282 3.6e-67 spxA 1.20.4.1 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
COHBPNKO_00283 2e-75 traP 1.14.99.57, 6.2.1.3 S enzyme involved in biosynthesis of extracellular polysaccharides
COHBPNKO_00285 1.7e-65 XK27_01125 L PFAM IS66 Orf2 family protein
COHBPNKO_00287 2.4e-98 2.3.1.128 K Acetyltransferase (GNAT) domain
COHBPNKO_00288 1.1e-237 lmrB EGP Major facilitator Superfamily
COHBPNKO_00289 0.0 nrdD 1.1.98.6 F Ribonucleoside-triphosphate reductase
COHBPNKO_00290 3.4e-111 nrdG 1.97.1.4 O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
COHBPNKO_00291 4.7e-160 sufD O Uncharacterized protein family (UPF0051)
COHBPNKO_00292 1.6e-42 lytE M LysM domain protein
COHBPNKO_00293 0.0 oppD EP Psort location Cytoplasmic, score
COHBPNKO_00294 4.2e-95 lytE M LysM domain protein
COHBPNKO_00295 9.2e-149 xth 3.1.11.2 L exodeoxyribonuclease III
COHBPNKO_00296 9.5e-236 preT 1.3.1.1 E Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
COHBPNKO_00297 4.5e-236 preA 1.3.1.1 C 4Fe-4S dicluster domain
COHBPNKO_00298 7e-223 L Transposase
COHBPNKO_00299 1.8e-104 K Transcriptional regulator C-terminal region
COHBPNKO_00300 3.4e-187 S membrane
COHBPNKO_00301 1.2e-112 GM NAD(P)H-binding
COHBPNKO_00302 4.4e-64 yneR
COHBPNKO_00303 1.3e-130 yfeJ 6.3.5.2 F glutamine amidotransferase
COHBPNKO_00304 5.3e-142 T EAL domain
COHBPNKO_00305 8.3e-254 pgaC GT2 M Glycosyl transferase
COHBPNKO_00306 3.3e-86
COHBPNKO_00307 9.3e-201 2.7.7.65 T GGDEF domain
COHBPNKO_00308 4.2e-124 yhjH 3.1.4.52 T Putative diguanylate phosphodiesterase
COHBPNKO_00309 1.3e-256 asnS 6.1.1.22 J Asparaginyl-tRNA synthetase
COHBPNKO_00310 4.9e-198 asnA 6.3.1.1 F aspartate--ammonia ligase
COHBPNKO_00311 3.4e-92 folT S ECF transporter, substrate-specific component
COHBPNKO_00312 0.0 pepN 3.4.11.2 E aminopeptidase
COHBPNKO_00313 4e-113 ylbE GM NAD dependent epimerase dehydratase family protein
COHBPNKO_00314 1e-256 pepC 3.4.22.40 E aminopeptidase
COHBPNKO_00315 1.7e-93 thiJ 2.7.11.1, 3.5.1.124 S DJ-1/PfpI family
COHBPNKO_00316 3e-184 I Alpha beta
COHBPNKO_00317 1.8e-265 emrY EGP Major facilitator Superfamily
COHBPNKO_00318 1.8e-116 ung2 3.2.2.27 L Uracil-DNA glycosylase
COHBPNKO_00319 9.4e-253 yjjP S Putative threonine/serine exporter
COHBPNKO_00320 6.7e-159 mleR K LysR family
COHBPNKO_00321 1.3e-252 yflS P Sodium:sulfate symporter transmembrane region
COHBPNKO_00322 3.4e-266 frdC 1.3.5.4 C FAD binding domain
COHBPNKO_00323 6.2e-260 fumC 4.2.1.2 C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
COHBPNKO_00324 6.3e-304 sfcA 1.1.1.38, 4.1.1.101 C Malic enzyme
COHBPNKO_00325 4.9e-157 mleR K LysR family
COHBPNKO_00326 1e-110 ppiB 5.2.1.8 G PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
COHBPNKO_00327 1.9e-205 adhA 1.1.1.1 C Zinc-binding alcohol dehydrogenase family protein
COHBPNKO_00328 9.8e-299 L PFAM plasmid pRiA4b ORF-3 family protein
COHBPNKO_00329 2.2e-265 S Uncharacterized protein conserved in bacteria (DUF2252)
COHBPNKO_00332 5.8e-22
COHBPNKO_00333 5.4e-200 galM 5.1.3.3 G Catalyzes the interconversion of alpha and beta anomers of maltose
COHBPNKO_00334 6.7e-75
COHBPNKO_00335 7.3e-220 dacA 3.4.16.4 M Belongs to the peptidase S11 family
COHBPNKO_00336 7.7e-130 ponA V Beta-lactamase enzyme family
COHBPNKO_00337 6.5e-284 gtfA 2.4.1.7 GH13 G Sucrose glucosyltransferase
COHBPNKO_00338 1.4e-215 uhpT EGP Major facilitator Superfamily
COHBPNKO_00339 3.6e-257 ytjP 3.5.1.18 E Dipeptidase
COHBPNKO_00340 5.7e-275 arcD S C4-dicarboxylate anaerobic carrier
COHBPNKO_00341 2.8e-179 yfeX P Peroxidase
COHBPNKO_00342 4.8e-170 lsa S ABC transporter
COHBPNKO_00343 1.9e-132 I alpha/beta hydrolase fold
COHBPNKO_00344 4.7e-180 MA20_14895 S Conserved hypothetical protein 698
COHBPNKO_00345 1.4e-95 S NADPH-dependent FMN reductase
COHBPNKO_00346 6.1e-171 mccA 2.5.1.134, 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
COHBPNKO_00347 8.6e-181 hemH 4.99.1.1, 4.99.1.9 H Catalyzes the ferrous insertion into protoporphyrin IX
COHBPNKO_00348 1.3e-230 mntH P H( )-stimulated, divalent metal cation uptake system
COHBPNKO_00349 3.7e-83 Q Methyltransferase
COHBPNKO_00350 6.9e-116 ktrA P domain protein
COHBPNKO_00351 1e-238 ktrB P Potassium uptake protein
COHBPNKO_00352 0.0 mycA 4.2.1.53 S Myosin-crossreactive antigen
COHBPNKO_00353 1.9e-138 nfrA 1.5.1.38, 1.5.1.39 C nitroreductase
COHBPNKO_00354 1.4e-217 G Glycosyl hydrolases family 8
COHBPNKO_00355 5e-243 ydaM M Glycosyl transferase
COHBPNKO_00356 7.8e-144
COHBPNKO_00357 3.9e-125 phoU P Plays a role in the regulation of phosphate uptake
COHBPNKO_00358 1.1e-136 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
COHBPNKO_00359 1.1e-153 pstA P Phosphate transport system permease protein PstA
COHBPNKO_00360 1.2e-152 pstC P probably responsible for the translocation of the substrate across the membrane
COHBPNKO_00361 9.6e-158 pstS P Phosphate
COHBPNKO_00362 3.1e-130 K Transcriptional regulatory protein, C-terminal domain protein
COHBPNKO_00363 7.8e-121 cbiO P ABC transporter
COHBPNKO_00364 3.4e-91 P Cobalt transport protein
COHBPNKO_00365 2.4e-163 nikMN P PDGLE domain
COHBPNKO_00366 3.4e-73 crcB U Important for reducing fluoride concentration in the cell, thus reducing its toxicity
COHBPNKO_00367 4.9e-42 crcB U Important for reducing fluoride concentration in the cell, thus reducing its toxicity
COHBPNKO_00368 9e-161 ureD O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
COHBPNKO_00369 4.7e-114 ureG KO Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
COHBPNKO_00370 2.1e-131 ureF O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
COHBPNKO_00371 2.5e-77 ureE O Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
COHBPNKO_00372 0.0 ureC 3.5.1.5 E Amidohydrolase family
COHBPNKO_00373 2.9e-63 ureB 3.5.1.5 E Urease beta subunit
COHBPNKO_00374 4e-47 ureA 3.5.1.5 E Urease, gamma subunit
COHBPNKO_00375 1.7e-98 ureI S AmiS/UreI family transporter
COHBPNKO_00376 2.6e-222 P ammonium transporter
COHBPNKO_00377 3.3e-17 K Transcriptional regulator, HxlR family
COHBPNKO_00378 3.4e-183
COHBPNKO_00379 1.2e-97 2.3.1.128 K acetyltransferase
COHBPNKO_00380 1.2e-111 brpA K Cell envelope-like function transcriptional attenuator common domain protein
COHBPNKO_00381 8.2e-93 lysR5 K LysR substrate binding domain
COHBPNKO_00382 3.3e-143 manA 5.3.1.8 G mannose-6-phosphate isomerase
COHBPNKO_00383 8.9e-159 K LysR substrate binding domain
COHBPNKO_00384 1.6e-205 1.1.1.90 C Zn-dependent alcohol dehydrogenases, class III
COHBPNKO_00385 4.9e-65 L Transposase IS200 like
COHBPNKO_00386 9.7e-182 L transposase, IS605 OrfB family
COHBPNKO_00387 3.6e-51 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
COHBPNKO_00388 2.4e-163
COHBPNKO_00389 6.4e-99 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
COHBPNKO_00390 7.1e-182 S Phosphotransferase system, EIIC
COHBPNKO_00391 3.5e-24
COHBPNKO_00392 2.7e-55
COHBPNKO_00393 2.9e-140
COHBPNKO_00394 3.7e-151 3.1.3.73 G Belongs to the phosphoglycerate mutase family
COHBPNKO_00395 1.3e-125 nagB 3.1.1.31, 3.5.99.6 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
COHBPNKO_00396 6.8e-104 fic D Fic/DOC family
COHBPNKO_00397 3.3e-71
COHBPNKO_00398 0.0 XK27_00340 3.1.3.5 F Belongs to the 5'-nucleotidase family
COHBPNKO_00399 7.1e-92 L nuclease
COHBPNKO_00400 0.0 sbcC L Putative exonuclease SbcCD, C subunit
COHBPNKO_00401 1.9e-211 sbcD L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
COHBPNKO_00402 5e-178 M Glycosyl hydrolases family 25
COHBPNKO_00403 1.2e-143 ywqE 3.1.3.48 GM PHP domain protein
COHBPNKO_00405 1e-37
COHBPNKO_00406 7.4e-67 T Toxin-antitoxin system, toxin component, MazF family
COHBPNKO_00408 1.7e-249 mmuP E amino acid
COHBPNKO_00409 3.1e-170 mmuM 1.5.1.20, 2.1.1.10 H homocysteine S-methyltransferase
COHBPNKO_00411 1.7e-59 S Protein of unknown function (DUF4065)
COHBPNKO_00413 7.1e-43 T PemK-like, MazF-like toxin of type II toxin-antitoxin system
COHBPNKO_00414 4.7e-25
COHBPNKO_00416 9.9e-34 L Reverse transcriptase (RNA-dependent DNA polymerase)
COHBPNKO_00417 1.6e-174 L Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
COHBPNKO_00418 5.5e-110 dedA S SNARE-like domain protein
COHBPNKO_00419 8.5e-103 S Protein of unknown function (DUF1461)
COHBPNKO_00420 7.2e-133 nagD 2.7.1.25, 3.1.3.41 G Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
COHBPNKO_00421 4.6e-94 yutD S Protein of unknown function (DUF1027)
COHBPNKO_00422 7.7e-114 S Calcineurin-like phosphoesterase
COHBPNKO_00423 2.2e-221 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
COHBPNKO_00424 8.5e-145 ytxK 2.1.1.72 L N-6 DNA Methylase
COHBPNKO_00426 2.8e-70
COHBPNKO_00427 8.4e-42
COHBPNKO_00428 4.9e-78 NU general secretion pathway protein
COHBPNKO_00429 5e-32 comGC U competence protein ComGC
COHBPNKO_00430 2.1e-183 comGB NU type II secretion system
COHBPNKO_00431 3.4e-180 comGA NU Type II IV secretion system protein
COHBPNKO_00432 3.5e-132 yebC K Transcriptional regulatory protein
COHBPNKO_00433 4.5e-136
COHBPNKO_00434 6.4e-182 ccpA K catabolite control protein A
COHBPNKO_00435 3.2e-211 pepQ 3.4.13.9 E Creatinase/Prolidase N-terminal domain
COHBPNKO_00436 4.1e-27
COHBPNKO_00437 6.5e-38 WQ51_05790 S protein containing a divergent version of the methyl-accepting chemotaxis-like domain
COHBPNKO_00438 3.4e-147 ykuT M mechanosensitive ion channel
COHBPNKO_00439 2.3e-153 3.1.3.102, 3.1.3.104, 3.1.3.23 S haloacid dehalogenase-like hydrolase
COHBPNKO_00440 5.7e-74 ykuL S (CBS) domain
COHBPNKO_00441 2e-94 S Phosphoesterase
COHBPNKO_00442 3.3e-101 rdgB 3.6.1.66, 5.1.1.3 F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
COHBPNKO_00443 1.2e-141 murI 3.6.1.66, 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
COHBPNKO_00444 4.6e-97 yslB S Protein of unknown function (DUF2507)
COHBPNKO_00445 6.1e-54 trxA O Belongs to the thioredoxin family
COHBPNKO_00446 0.0 mutS2 L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
COHBPNKO_00447 1.6e-86 cvpA S Colicin V production protein
COHBPNKO_00448 6.1e-48 yrzB S Belongs to the UPF0473 family
COHBPNKO_00449 3.6e-76 yqgF J Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
COHBPNKO_00450 4.1e-43 yrzL S Belongs to the UPF0297 family
COHBPNKO_00451 0.0 alaS 6.1.1.7 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
COHBPNKO_00452 3.7e-233 cshB 3.6.4.13 JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
COHBPNKO_00453 4.2e-183 nrnA 3.1.13.3, 3.1.3.7 S DHHA1 domain protein
COHBPNKO_00454 2.8e-31 yajC U Preprotein translocase
COHBPNKO_00455 6.9e-190 tgt_1 2.4.2.29 F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
COHBPNKO_00456 3.4e-191 ruvB 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
COHBPNKO_00457 3.9e-102 ruvA 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
COHBPNKO_00458 0.0 mutL L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
COHBPNKO_00459 0.0 mutS L that it carries out the mismatch recognition step. This protein has a weak ATPase activity
COHBPNKO_00460 9.5e-209 rny S Endoribonuclease that initiates mRNA decay
COHBPNKO_00461 7.6e-197 recA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
COHBPNKO_00462 8.4e-232 cinA 3.5.1.42 S Belongs to the CinA family
COHBPNKO_00463 2.5e-101 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
COHBPNKO_00464 6.7e-150 ymfM S Helix-turn-helix domain
COHBPNKO_00465 2.7e-249 ymfH S Peptidase M16
COHBPNKO_00466 1.7e-229 ymfF S Peptidase M16 inactive domain protein
COHBPNKO_00467 1.3e-159 aatB ET ABC transporter substrate-binding protein
COHBPNKO_00468 3.6e-117 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
COHBPNKO_00469 3.2e-102 glnP P ABC transporter permease
COHBPNKO_00470 8.7e-93 mreD M rod shape-determining protein MreD
COHBPNKO_00471 5.9e-152 mreC M Involved in formation and maintenance of cell shape
COHBPNKO_00472 1.7e-179 mreB D cell shape determining protein MreB
COHBPNKO_00473 6.8e-121 radC L DNA repair protein
COHBPNKO_00474 1e-243 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
COHBPNKO_00475 9e-231 ndh 1.6.99.3 C NADH dehydrogenase
COHBPNKO_00476 0.0 cydD CO ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
COHBPNKO_00477 5.1e-309 cydD CO ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydD
COHBPNKO_00478 4.1e-184 cydB 1.10.3.14 C Cytochrome d ubiquinol oxidase subunit II
COHBPNKO_00479 1.5e-272 cydA 1.10.3.14 C ubiquinol oxidase
COHBPNKO_00480 0.0 valS 6.1.1.9 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
COHBPNKO_00481 4.2e-228 thiI 2.8.1.4 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
COHBPNKO_00482 1.1e-214 iscS2 2.8.1.7 E Aminotransferase class V
COHBPNKO_00483 1.7e-251 ezrA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
COHBPNKO_00484 3.7e-108 rpsD J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
COHBPNKO_00485 3.1e-235 pbuG S permease
COHBPNKO_00486 4.9e-262 frc 2.8.3.16 C Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate
COHBPNKO_00487 0.0 oxc 4.1.1.8 EH Belongs to the TPP enzyme family
COHBPNKO_00488 5.3e-141 S Belongs to the UPF0246 family
COHBPNKO_00489 2.5e-138 S Membrane
COHBPNKO_00490 8.1e-75 4.4.1.5 E Glyoxalase
COHBPNKO_00491 1.5e-21
COHBPNKO_00492 2.7e-85 yueI S Protein of unknown function (DUF1694)
COHBPNKO_00493 6.5e-243 rarA L recombination factor protein RarA
COHBPNKO_00494 4.4e-46
COHBPNKO_00495 4.3e-83 usp6 T universal stress protein
COHBPNKO_00496 3.3e-147 2.3.1.19 K Helix-turn-helix XRE-family like proteins
COHBPNKO_00497 3.1e-217 ddl 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
COHBPNKO_00498 1.4e-47 gcvH E glycine cleavage
COHBPNKO_00499 1.1e-220 rodA D Belongs to the SEDS family
COHBPNKO_00500 1e-31 S Protein of unknown function (DUF2969)
COHBPNKO_00501 1.9e-178 mbl D Cell shape determining protein MreB Mrl
COHBPNKO_00502 4.2e-242 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
COHBPNKO_00503 1.3e-33 ywzB S Protein of unknown function (DUF1146)
COHBPNKO_00504 1.6e-68 atpC C Produces ATP from ADP in the presence of a proton gradient across the membrane
COHBPNKO_00505 1.1e-267 atpD 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
COHBPNKO_00506 1.9e-164 atpG C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
COHBPNKO_00507 4e-284 atpA 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
COHBPNKO_00508 5.1e-93 atpH C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
COHBPNKO_00509 1.1e-57 atpF C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
COHBPNKO_00510 1.5e-14 atpE C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
COHBPNKO_00511 7.3e-124 atpB C it plays a direct role in the translocation of protons across the membrane
COHBPNKO_00512 1.7e-232 pyrP F Permease
COHBPNKO_00513 2e-130 yibF S overlaps another CDS with the same product name
COHBPNKO_00514 1.5e-187 yibE S overlaps another CDS with the same product name
COHBPNKO_00515 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
COHBPNKO_00516 6.6e-116 upp 2.4.2.9 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
COHBPNKO_00517 1.1e-228 glyA 2.1.2.1 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
COHBPNKO_00518 1.2e-196 ywlC 2.7.7.87, 3.1.3.48 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
COHBPNKO_00519 7e-169 prmB 2.1.1.297, 2.1.1.298 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
COHBPNKO_00520 1.2e-194 prfA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
COHBPNKO_00521 6e-108 tdk 2.7.1.21 F thymidine kinase
COHBPNKO_00522 1.5e-263 murD 3.4.21.10, 6.3.2.13, 6.3.2.9 M Mur ligase, middle domain
COHBPNKO_00523 4.1e-135 cobQ S CobB/CobQ-like glutamine amidotransferase domain
COHBPNKO_00524 2.1e-223 arcD U Amino acid permease
COHBPNKO_00525 7.5e-261 E Arginine ornithine antiporter
COHBPNKO_00526 2.7e-79 argR K Regulates arginine biosynthesis genes
COHBPNKO_00527 6.5e-237 arcA 3.5.3.6 E Arginine
COHBPNKO_00528 2.2e-193 ampC V Beta-lactamase
COHBPNKO_00529 6.6e-33
COHBPNKO_00530 0.0 M domain protein
COHBPNKO_00531 5e-90
COHBPNKO_00532 5e-210 EGP Major facilitator Superfamily
COHBPNKO_00533 4.1e-237
COHBPNKO_00534 3.1e-83 K Transcriptional regulator, HxlR family
COHBPNKO_00535 3.3e-109 XK27_02070 S Nitroreductase family
COHBPNKO_00536 2.8e-51 hxlR K Transcriptional regulator, HxlR family
COHBPNKO_00537 1.4e-121 GM NmrA-like family
COHBPNKO_00538 8.4e-78 elaA S Gnat family
COHBPNKO_00539 1.8e-39 S Cytochrome B5
COHBPNKO_00540 5.4e-09 S Cytochrome B5
COHBPNKO_00541 1.6e-41 S Cytochrome B5
COHBPNKO_00542 1e-212 yxjG_1 E methionine synthase, vitamin-B12 independent
COHBPNKO_00544 1.4e-181 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
COHBPNKO_00545 3.7e-241 E amino acid
COHBPNKO_00546 9.5e-255 npp S type I phosphodiesterase nucleotide pyrophosphatase
COHBPNKO_00547 4.3e-228 yxiO S Vacuole effluxer Atg22 like
COHBPNKO_00549 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
COHBPNKO_00550 1.6e-30
COHBPNKO_00551 3e-290 mntH P H( )-stimulated, divalent metal cation uptake system
COHBPNKO_00552 9.9e-191 tdh 1.1.1.14 E Alcohol dehydrogenase GroES-like domain
COHBPNKO_00553 1.4e-226 mgs 2.4.1.337 GT4 M Glycosyltransferase, group 1 family protein
COHBPNKO_00554 1.6e-199 cpoA GT4 M Glycosyltransferase, group 1 family protein
COHBPNKO_00555 1.1e-178 mprF I Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
COHBPNKO_00557 3e-49 yrvD S Pfam:DUF1049
COHBPNKO_00558 9.1e-46 3.1.3.102, 3.1.3.104 S hydrolase
COHBPNKO_00559 5.2e-89 ntd 2.4.2.6 F Nucleoside
COHBPNKO_00560 1.2e-18
COHBPNKO_00561 6.8e-164 S Alpha/beta hydrolase of unknown function (DUF915)
COHBPNKO_00562 8.1e-114 yviA S Protein of unknown function (DUF421)
COHBPNKO_00563 1.2e-71 S Protein of unknown function (DUF3290)
COHBPNKO_00564 3.5e-42 ybaN S Protein of unknown function (DUF454)
COHBPNKO_00565 0.0 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
COHBPNKO_00566 2.5e-150 endA V DNA/RNA non-specific endonuclease
COHBPNKO_00567 7.8e-255 yifK E Amino acid permease
COHBPNKO_00569 0.0 dxs 2.2.1.7 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
COHBPNKO_00570 5.1e-229 N Uncharacterized conserved protein (DUF2075)
COHBPNKO_00571 1e-122 S SNARE associated Golgi protein
COHBPNKO_00572 0.0 uvrA3 L excinuclease ABC, A subunit
COHBPNKO_00573 4.5e-55 crcB U Important for reducing fluoride concentration in the cell, thus reducing its toxicity
COHBPNKO_00574 5.4e-57 crcB D Important for reducing fluoride concentration in the cell, thus reducing its toxicity
COHBPNKO_00575 8.3e-69 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
COHBPNKO_00576 1.5e-144 S DUF218 domain
COHBPNKO_00577 0.0 ubiB S ABC1 family
COHBPNKO_00578 8.5e-246 yhdP S Transporter associated domain
COHBPNKO_00579 7.2e-74 copY K Copper transport repressor CopY TcrY
COHBPNKO_00580 2.5e-237 EGP Major facilitator Superfamily
COHBPNKO_00581 4.5e-74 yeaL S UPF0756 membrane protein
COHBPNKO_00582 6.6e-80 yphH S Cupin domain
COHBPNKO_00583 7.2e-83 C Flavodoxin
COHBPNKO_00584 5.5e-161 K LysR substrate binding domain protein
COHBPNKO_00585 4e-167 1.1.1.346 C Aldo keto reductase
COHBPNKO_00586 2.1e-39 gcvR T Belongs to the UPF0237 family
COHBPNKO_00587 8.7e-243 XK27_08635 S UPF0210 protein
COHBPNKO_00588 2.4e-95 K Acetyltransferase (GNAT) domain
COHBPNKO_00589 1.2e-160 S Alpha beta hydrolase
COHBPNKO_00590 1.4e-158 gspA M family 8
COHBPNKO_00591 8.7e-229 L transposase, IS605 OrfB family
COHBPNKO_00592 9.5e-77 tlpA2 L Transposase IS200 like
COHBPNKO_00593 2.3e-116 ypgQ S Metal dependent phosphohydrolases with conserved 'HD' motif.
COHBPNKO_00594 1.9e-92
COHBPNKO_00595 3.2e-161 degV S EDD domain protein, DegV family
COHBPNKO_00596 0.0 FbpA K Fibronectin-binding protein
COHBPNKO_00597 0.0 carB 6.3.5.5 F Carbamoyl-phosphate synthase
COHBPNKO_00598 2.1e-207 carA 6.3.5.5 F Belongs to the CarA family
COHBPNKO_00599 1.4e-175 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
COHBPNKO_00600 1.1e-72 lspA 3.4.23.36 MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins
COHBPNKO_00601 1.5e-65 esbA S Family of unknown function (DUF5322)
COHBPNKO_00602 2e-70 rnhA 3.1.26.4 L Ribonuclease HI
COHBPNKO_00603 2.3e-223 rlmL 2.1.1.173, 2.1.1.264 L Belongs to the methyltransferase superfamily
COHBPNKO_00604 3.2e-83 F Belongs to the NrdI family
COHBPNKO_00605 2.1e-200 L Transposase
COHBPNKO_00606 7e-223 L Transposase
COHBPNKO_00607 1.2e-55 K Transcriptional regulator, ArsR family
COHBPNKO_00608 8.5e-91 P Cadmium resistance transporter
COHBPNKO_00609 8.2e-137 XK27_08845 S ABC transporter, ATP-binding protein
COHBPNKO_00610 1.1e-153 XK27_08840 U Belongs to the binding-protein-dependent transport system permease family
COHBPNKO_00611 9.8e-183 ABC-SBP S ABC transporter
COHBPNKO_00612 2.9e-73 M PFAM NLP P60 protein
COHBPNKO_00613 8.1e-08 S Domain of unknown function (DUF296)
COHBPNKO_00615 2.9e-11
COHBPNKO_00616 3.8e-274 S ABC transporter, ATP-binding protein
COHBPNKO_00617 2.3e-142 S Putative ABC-transporter type IV
COHBPNKO_00618 2.6e-106 NU mannosyl-glycoprotein
COHBPNKO_00619 2.4e-248 brnQ U Component of the transport system for branched-chain amino acids
COHBPNKO_00620 2.4e-231 S Uncharacterized protein conserved in bacteria (DUF2325)
COHBPNKO_00621 5.8e-205 nrnB S DHHA1 domain
COHBPNKO_00622 6.3e-50
COHBPNKO_00623 1.3e-134 2.1.1.72 D peptidase
COHBPNKO_00624 1e-16 S Domain of unknown function (DUF4767)
COHBPNKO_00625 3.6e-54
COHBPNKO_00626 9.9e-118 yrkL S Flavodoxin-like fold
COHBPNKO_00628 1.4e-65 yeaO S Protein of unknown function, DUF488
COHBPNKO_00629 1.2e-120 mpg 3.2.2.21 L Belongs to the DNA glycosylase MPG family
COHBPNKO_00630 3.4e-203 3.1.3.1 S associated with various cellular activities
COHBPNKO_00631 4.9e-243 S Putative metallopeptidase domain
COHBPNKO_00632 4.6e-48
COHBPNKO_00633 0.0 pepO 3.4.24.71 O Peptidase family M13
COHBPNKO_00634 9.9e-104 K Helix-turn-helix domain
COHBPNKO_00635 1.4e-87 ymdB S Macro domain protein
COHBPNKO_00636 1.4e-196 EGP Major facilitator Superfamily
COHBPNKO_00637 7.1e-286 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
COHBPNKO_00638 1.1e-250 L PFAM transposase, IS4 family protein
COHBPNKO_00639 7e-223 L Transposase
COHBPNKO_00640 3.1e-170 whiA K May be required for sporulation
COHBPNKO_00641 1.1e-186 ybhK S Required for morphogenesis under gluconeogenic growth conditions
COHBPNKO_00642 1.1e-161 rapZ S Displays ATPase and GTPase activities
COHBPNKO_00643 2.4e-245 steT E amino acid
COHBPNKO_00644 0.0 uvrA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
COHBPNKO_00645 0.0 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
COHBPNKO_00646 1.5e-13
COHBPNKO_00647 2.3e-116 yfbR S HD containing hydrolase-like enzyme
COHBPNKO_00648 0.0 pgm 5.4.2.2, 5.4.2.8 G Phosphoglucomutase phosphomannomutase, alpha beta alpha domain
COHBPNKO_00649 7.2e-89 ykhA 3.1.2.20 I Thioesterase superfamily
COHBPNKO_00650 1.1e-161 aatB ET PFAM extracellular solute-binding protein, family 3
COHBPNKO_00651 1.3e-213 argE 3.5.1.18 E succinyl-diaminopimelate desuccinylase
COHBPNKO_00652 5e-173 trxB 1.8.1.9 C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
COHBPNKO_00653 4e-158 lutA C Cysteine-rich domain
COHBPNKO_00654 4.1e-286 lutB C 4Fe-4S dicluster domain
COHBPNKO_00655 1.7e-136 yrjD S LUD domain
COHBPNKO_00656 1.1e-169 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
COHBPNKO_00657 7.7e-183 gpsA 1.1.1.94 I Glycerol-3-phosphate dehydrogenase
COHBPNKO_00658 1.3e-156 lgt 2.1.1.199 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
COHBPNKO_00659 4.6e-177 hprK F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
COHBPNKO_00660 4.9e-52 yvlD S Mycobacterial 4 TMS phage holin, superfamily IV
COHBPNKO_00661 2.4e-32 KT PspC domain protein
COHBPNKO_00662 1.7e-187 prfB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
COHBPNKO_00663 0.0 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
COHBPNKO_00664 3e-93 hpf J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
COHBPNKO_00665 2.3e-122 comFC S Competence protein
COHBPNKO_00666 2.5e-250 comFA L Helicase C-terminal domain protein
COHBPNKO_00667 5e-108 yvyE 3.4.13.9 S YigZ family
COHBPNKO_00668 1.7e-24 K transcriptional regulator
COHBPNKO_00669 6e-40 C nitroreductase
COHBPNKO_00670 3.7e-236 EGP Major facilitator Superfamily
COHBPNKO_00671 3.3e-68 rmaI K Transcriptional regulator
COHBPNKO_00672 9.2e-40
COHBPNKO_00673 0.0 ydaO E amino acid
COHBPNKO_00674 2e-302 ybeC E amino acid
COHBPNKO_00675 4.2e-86 S Aminoacyl-tRNA editing domain
COHBPNKO_00676 1.9e-292 groL O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
COHBPNKO_00677 1.1e-43 groS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
COHBPNKO_00679 8.2e-114 rex K Modulates transcription in response to changes in cellular NADH NAD( ) redox state
COHBPNKO_00680 0.0 uup S ABC transporter, ATP-binding protein
COHBPNKO_00681 5.2e-181 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
COHBPNKO_00682 4.5e-227 mtnE 2.6.1.83 E Aminotransferase
COHBPNKO_00683 3.9e-142 mtnU 3.5.1.3 S Carbon-nitrogen hydrolase
COHBPNKO_00684 3.2e-136 proB 2.7.2.11 F Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
COHBPNKO_00685 3.6e-227 proA 1.2.1.41 E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
COHBPNKO_00686 4.2e-133 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
COHBPNKO_00687 9.5e-197 tsaD 2.3.1.234 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
COHBPNKO_00688 3.6e-102 rimI 2.3.1.128 K Ribosomal-protein-alanine acetyltransferase
COHBPNKO_00689 3.5e-129 yeaZ 2.3.1.234 O Universal bacterial protein YeaZ
COHBPNKO_00690 1.5e-194 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
COHBPNKO_00691 2.5e-175 ppx 3.6.1.11, 3.6.1.40 FP exopolyphosphatase
COHBPNKO_00692 0.0 ppk 2.7.4.1 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
COHBPNKO_00693 1.2e-280 ppx3 3.6.1.11, 3.6.1.40 FP exopolyphosphatase
COHBPNKO_00694 4.4e-214 5.4.2.7 G Phosphotransfer between the C1 and C5 carbon atoms of pentose
COHBPNKO_00695 9.4e-309 cadA P P-type ATPase
COHBPNKO_00696 2.2e-115 XK27_08875 O PFAM peptidase M10A and M12B, matrixin and adamalysin
COHBPNKO_00697 1.3e-128
COHBPNKO_00698 1.8e-53 S Sugar efflux transporter for intercellular exchange
COHBPNKO_00699 1.5e-247 merA 1.16.1.1, 1.8.1.7 C Pyridine nucleotide-disulfide oxidoreductase
COHBPNKO_00701 0.0 L Helicase C-terminal domain protein
COHBPNKO_00702 1.3e-74 3.1.3.27, 3.1.3.4, 3.1.3.81, 3.6.1.27 I PAP2 superfamily
COHBPNKO_00703 3.7e-179 S Aldo keto reductase
COHBPNKO_00705 3.2e-141 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
COHBPNKO_00706 2.7e-62 psiE S Phosphate-starvation-inducible E
COHBPNKO_00707 6.9e-98 ydeN S Serine hydrolase
COHBPNKO_00709 2e-183 P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
COHBPNKO_00710 2e-253 nhaC C Na H antiporter NhaC
COHBPNKO_00711 1.2e-38 S Cytochrome b5-like Heme/Steroid binding domain
COHBPNKO_00712 3.7e-114 ywnB S NAD(P)H-binding
COHBPNKO_00713 3.7e-37
COHBPNKO_00714 6.5e-131 IQ Dehydrogenase reductase
COHBPNKO_00715 4.8e-143 yhjE EGP MFS transporter, metabolite H symporter (MHS) family protein
COHBPNKO_00716 1.5e-71 yhjE EGP MFS transporter, metabolite H symporter (MHS) family protein
COHBPNKO_00717 8.3e-88
COHBPNKO_00735 2.8e-260 xylT EGP Major facilitator Superfamily
COHBPNKO_00736 9.5e-172 rhaS2 K Transcriptional regulator, AraC family
COHBPNKO_00737 5.3e-289 xynT G MFS/sugar transport protein
COHBPNKO_00738 0.0 3.2.1.55 GH51 G Right handed beta helix region
COHBPNKO_00739 3.1e-135 xylR GK ROK family
COHBPNKO_00740 1.3e-236 xynP G MFS/sugar transport protein
COHBPNKO_00741 0.0 yicI 3.2.1.177 GH31 G Belongs to the glycosyl hydrolase 31 family
COHBPNKO_00742 7.6e-271 xylA 5.3.1.5 G Belongs to the xylose isomerase family
COHBPNKO_00743 2.1e-298 xylB 2.7.1.17 G Belongs to the FGGY kinase family
COHBPNKO_00744 0.0 3.2.1.21 GH3 G hydrolase, family 3
COHBPNKO_00745 6.2e-154 KT YcbB domain
COHBPNKO_00746 5.8e-191 argF 2.1.3.3 E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
COHBPNKO_00747 8.1e-171 arcC 2.7.2.2 E Belongs to the carbamate kinase family
COHBPNKO_00748 1e-162 EG EamA-like transporter family
COHBPNKO_00749 7.7e-103 XK27_08875 O PFAM peptidase M10A and M12B, matrixin and adamalysin
COHBPNKO_00750 3.8e-55 silP 1.9.3.1, 3.6.3.54 S Cupredoxin-like domain
COHBPNKO_00751 6.3e-50 silP 1.9.3.1, 3.6.3.54 S Cupredoxin-like domain
COHBPNKO_00752 0.0 copA 3.6.3.54 P P-type ATPase
COHBPNKO_00753 8.8e-89
COHBPNKO_00755 3.6e-57
COHBPNKO_00756 3.5e-162 yjcE P Sodium proton antiporter
COHBPNKO_00757 3.2e-62 yjcE P Sodium proton antiporter
COHBPNKO_00763 1.7e-14 arpU S Phage transcriptional regulator, ArpU family
COHBPNKO_00764 6.4e-104 S D5 N terminal like
COHBPNKO_00765 3.6e-47
COHBPNKO_00767 3.3e-12
COHBPNKO_00769 1.3e-16 S Helix-turn-helix domain
COHBPNKO_00771 1.5e-131 L Belongs to the 'phage' integrase family
COHBPNKO_00792 1.8e-24 S Acyltransferase family
COHBPNKO_00795 2.1e-48 S Glycosyltransferase, group 2 family protein
COHBPNKO_00796 7.7e-31 S COG0463 Glycosyltransferases involved in cell wall biogenesis
COHBPNKO_00797 2.7e-31 2.7.8.12 M Glycosyltransferase, group 2 family protein
COHBPNKO_00798 1.7e-30 M Glycosyltransferase sugar-binding region containing DXD motif
COHBPNKO_00799 3.7e-72 cps2I S Psort location CytoplasmicMembrane, score
COHBPNKO_00801 3e-40 M Pfam:DUF1792
COHBPNKO_00802 2e-66 sacB GT2,GT4 M Stealth protein CR2, conserved region 2
COHBPNKO_00803 2.4e-87 GT4 G Glycosyl transferase 4-like
COHBPNKO_00804 4.4e-48 pglC M Bacterial sugar transferase
COHBPNKO_00805 2.1e-105 ywqD 2.7.10.1 D Capsular exopolysaccharide family
COHBPNKO_00806 5.2e-99 epsB M biosynthesis protein
COHBPNKO_00808 0.0 sprD D Domain of Unknown Function (DUF1542)
COHBPNKO_00809 1.4e-249 cshA 3.6.4.13 F DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
COHBPNKO_00810 5.8e-258 murF 6.3.2.10 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
COHBPNKO_00811 1.5e-158 htpX O Belongs to the peptidase M48B family
COHBPNKO_00812 1.2e-89 lemA S LemA family
COHBPNKO_00813 5.2e-86 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
COHBPNKO_00814 6e-120 pgm3 G Belongs to the phosphoglycerate mutase family
COHBPNKO_00815 1.2e-163 fba 4.1.2.13, 4.1.2.29 G Fructose-1,6-bisphosphate aldolase, class II
COHBPNKO_00816 2.6e-138 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
COHBPNKO_00817 2.1e-159 3.2.1.55 GH51 G Right handed beta helix region
COHBPNKO_00818 0.0 ppsA 2.7.9.2 H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate
COHBPNKO_00819 2.5e-124 srtA 3.4.22.70 M sortase family
COHBPNKO_00820 6.7e-167 S Alpha/beta hydrolase of unknown function (DUF915)
COHBPNKO_00821 1.7e-238 pts13C G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
COHBPNKO_00822 4.6e-41 rpmE2 J Ribosomal protein L31
COHBPNKO_00823 1.4e-237 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
COHBPNKO_00824 0.0 pyrG 6.3.4.2 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
COHBPNKO_00825 8.8e-48 rpoE K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
COHBPNKO_00826 5.2e-53 ywiB S Domain of unknown function (DUF1934)
COHBPNKO_00827 3.9e-153 lipL 2.3.1.200, 2.3.1.204 H biotin lipoate A B protein ligase
COHBPNKO_00828 3.8e-270 ywfO S HD domain protein
COHBPNKO_00829 7.1e-147 yxeH S hydrolase
COHBPNKO_00830 5.6e-50
COHBPNKO_00831 1.1e-178 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
COHBPNKO_00832 1.5e-242 glmU 2.3.1.157, 2.7.7.23 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
COHBPNKO_00833 6.9e-150 purR 2.4.2.22, 2.4.2.7 F pur operon repressor
COHBPNKO_00834 1.6e-127 znuB U ABC 3 transport family
COHBPNKO_00835 2.2e-122 fhuC P ABC transporter
COHBPNKO_00836 3.4e-166 znuA P Belongs to the bacterial solute-binding protein 9 family
COHBPNKO_00837 3.1e-161 ispE 2.1.1.182, 2.7.1.148 F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
COHBPNKO_00838 6.8e-37 veg S Biofilm formation stimulator VEG
COHBPNKO_00839 4e-159 ksgA 2.1.1.182 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
COHBPNKO_00840 5e-99 rnmV 3.1.26.8 J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
COHBPNKO_00841 8.4e-156 tatD L hydrolase, TatD family
COHBPNKO_00842 0.0 metG 6.1.1.10 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
COHBPNKO_00843 4e-161 yunF F Protein of unknown function DUF72
COHBPNKO_00845 1.6e-131 cobB K SIR2 family
COHBPNKO_00846 5.5e-175
COHBPNKO_00847 5.9e-225 mvaA 1.1.1.34, 1.1.1.88, 2.3.1.9 C Belongs to the HMG-CoA reductase family
COHBPNKO_00848 1.8e-165 ppx 3.6.1.11, 3.6.1.40 FP exopolyphosphatase
COHBPNKO_00849 5.9e-191 trpS 6.1.1.2 J Belongs to the class-I aminoacyl-tRNA synthetase family
COHBPNKO_00850 4.2e-183 hpaIM 2.1.1.72 L Belongs to the N(4) N(6)-methyltransferase family
COHBPNKO_00851 2.2e-81 ndk 2.7.4.6 F Belongs to the NDK family
COHBPNKO_00852 0.0 helD 3.6.4.12 L DNA helicase
COHBPNKO_00853 2.6e-203 napA P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
COHBPNKO_00855 9.1e-256 gabT 2.6.1.19 E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
COHBPNKO_00856 1.8e-265 yfnA E amino acid
COHBPNKO_00857 3.2e-118 nth 4.2.99.18 L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
COHBPNKO_00858 7.3e-43 1.3.5.4 S FMN binding
COHBPNKO_00859 2.2e-221 norA EGP Major facilitator Superfamily
COHBPNKO_00860 2.3e-170 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
COHBPNKO_00861 2.8e-154 metQ1 P Belongs to the nlpA lipoprotein family
COHBPNKO_00862 2.8e-191 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
COHBPNKO_00863 4.1e-103 metI P ABC transporter permease
COHBPNKO_00864 2.2e-218 argE 3.5.1.18 E succinyl-diaminopimelate desuccinylase
COHBPNKO_00865 5.4e-253 clcA P chloride
COHBPNKO_00866 2.2e-78 msrB 1.8.4.11, 1.8.4.12 O peptide methionine sulfoxide reductase
COHBPNKO_00867 3.8e-103 proW P ABC transporter, permease protein
COHBPNKO_00868 5e-142 proV E ABC transporter, ATP-binding protein
COHBPNKO_00869 1.1e-108 proWZ P ABC transporter permease
COHBPNKO_00870 2.3e-162 proX M ABC transporter, substrate-binding protein, QAT family
COHBPNKO_00871 3.8e-73 K Transcriptional regulator
COHBPNKO_00872 4.3e-155 1.6.5.2 GM NAD(P)H-binding
COHBPNKO_00874 2.5e-29 L PFAM transposase IS200-family protein
COHBPNKO_00875 4.4e-39 ykuJ S Protein of unknown function (DUF1797)
COHBPNKO_00877 0.0 mprF 2.3.2.3 S Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
COHBPNKO_00879 1.7e-162 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 J Responsible for synthesis of pseudouridine from uracil
COHBPNKO_00880 3.3e-119 S Domain of unknown function (DUF4811)
COHBPNKO_00881 2.1e-269 lmrB EGP Major facilitator Superfamily
COHBPNKO_00882 4.9e-73 merR K MerR HTH family regulatory protein
COHBPNKO_00883 5.1e-54
COHBPNKO_00884 0.0 rnjA J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
COHBPNKO_00885 7.7e-219 S CAAX protease self-immunity
COHBPNKO_00886 1.4e-108 glnP P ABC transporter permease
COHBPNKO_00887 3.2e-110 gluC P ABC transporter permease
COHBPNKO_00888 6.7e-153 glnH ET ABC transporter
COHBPNKO_00889 6.9e-133 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
COHBPNKO_00890 2.7e-82 usp1 T Belongs to the universal stress protein A family
COHBPNKO_00891 4.9e-109 S VIT family
COHBPNKO_00892 2.9e-117 S membrane
COHBPNKO_00893 9.1e-167 czcD P cation diffusion facilitator family transporter
COHBPNKO_00894 2.4e-124 sirR K iron dependent repressor
COHBPNKO_00895 1e-30 cspC K Cold shock protein
COHBPNKO_00896 8.1e-129 thrE S Putative threonine/serine exporter
COHBPNKO_00897 2.1e-82 S Threonine/Serine exporter, ThrE
COHBPNKO_00898 2.3e-119 lssY 3.6.1.27 I phosphatase
COHBPNKO_00899 6.5e-10 2.3.1.128 J Acetyltransferase (GNAT) domain
COHBPNKO_00900 2.3e-276 lysP E amino acid
COHBPNKO_00901 2.8e-114 dak 2.7.1.74, 2.7.1.76 F deoxynucleoside kinase
COHBPNKO_00907 2.3e-11
COHBPNKO_00908 2.6e-180 S Hydrolases of the alpha beta superfamily
COHBPNKO_00909 3.6e-196 adhP 1.1.1.1 C alcohol dehydrogenase
COHBPNKO_00910 3.4e-77 ctsR K Belongs to the CtsR family
COHBPNKO_00911 0.0 clpC O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
COHBPNKO_00912 1e-110 K Bacterial regulatory proteins, tetR family
COHBPNKO_00913 0.0 rpoB 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
COHBPNKO_00914 0.0 rpoC 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
COHBPNKO_00915 6.1e-200 ykiI
COHBPNKO_00916 3.4e-118 pilD 3.4.23.43 NOU Bacterial Peptidase A24 N-terminal domain
COHBPNKO_00917 3.9e-72 rpsL J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
COHBPNKO_00918 2.4e-83 rpsG J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
COHBPNKO_00919 0.0 fusA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
COHBPNKO_00920 3.4e-49 rpsJ J Involved in the binding of tRNA to the ribosomes
COHBPNKO_00921 1.5e-118 rplC J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
COHBPNKO_00922 5.5e-107 rplD J Forms part of the polypeptide exit tunnel
COHBPNKO_00923 5.7e-46 rplW J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
COHBPNKO_00924 4.2e-150 rplB J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
COHBPNKO_00925 1.4e-46 rpsS J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
COHBPNKO_00926 2.8e-52 rplV J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
COHBPNKO_00927 6.1e-112 rpsC J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
COHBPNKO_00928 3.5e-76 rplP J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
COHBPNKO_00929 8.4e-28 rpmC J Belongs to the universal ribosomal protein uL29 family
COHBPNKO_00930 5e-41 rpsQ J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
COHBPNKO_00931 1.1e-59 rplN J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
COHBPNKO_00932 2.6e-49 rplX J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
COHBPNKO_00933 1.4e-95 rplE J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
COHBPNKO_00934 1.3e-66 rpsH J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
COHBPNKO_00935 3.2e-95 rplF J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
COHBPNKO_00936 6.6e-57 rplR J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
COHBPNKO_00937 2.2e-85 rpsE J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
COHBPNKO_00938 2.9e-24 rpmD J Ribosomal protein L30
COHBPNKO_00939 8.9e-64 rplO J Binds to the 23S rRNA
COHBPNKO_00940 8.8e-240 secY U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
COHBPNKO_00941 8.1e-125 adk 2.7.4.3 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
COHBPNKO_00942 3.5e-32 infA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
COHBPNKO_00943 1.4e-14 rpmJ J Belongs to the bacterial ribosomal protein bL36 family
COHBPNKO_00944 4.7e-58 rpsM J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
COHBPNKO_00945 2.3e-63 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
COHBPNKO_00946 2.8e-171 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
COHBPNKO_00947 1.1e-62 rplQ J Ribosomal protein L17
COHBPNKO_00948 2.6e-144 ecfA1 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
COHBPNKO_00949 2.2e-154 ecfA2 3.6.3.55 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
COHBPNKO_00950 7.5e-141 ecfT U Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
COHBPNKO_00951 3.2e-141 truA 5.4.99.12 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
COHBPNKO_00952 4.5e-79 rplM J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
COHBPNKO_00953 5.6e-65 rpsI J Belongs to the universal ribosomal protein uS9 family
COHBPNKO_00954 9.4e-141 IQ reductase
COHBPNKO_00955 1e-113 acmC 3.2.1.96 NU mannosyl-glycoprotein
COHBPNKO_00956 3.5e-100 xpt 2.4.2.22, 2.4.2.7 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
COHBPNKO_00957 3.6e-213 purK2 6.3.4.18 F Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
COHBPNKO_00958 0.0 pcrA 3.6.4.12 L ATP-dependent DNA helicase
COHBPNKO_00959 0.0 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
COHBPNKO_00960 1.2e-202 camS S sex pheromone
COHBPNKO_00961 2.4e-50 gatC 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
COHBPNKO_00962 4.1e-278 gatA 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
COHBPNKO_00963 5.4e-275 gatB 6.1.1.12, 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
COHBPNKO_00964 6.7e-187 yegS 2.7.1.107 G Lipid kinase
COHBPNKO_00965 7.7e-263 rumA 2.1.1.190 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
COHBPNKO_00968 3.8e-68 K Psort location Cytoplasmic, score
COHBPNKO_00969 7.7e-88 entB 3.5.1.19 Q Isochorismatase family
COHBPNKO_00970 4e-90 K Bacterial regulatory proteins, tetR family
COHBPNKO_00971 5.9e-71 1.6.5.2 S NADPH-dependent FMN reductase
COHBPNKO_00972 1.1e-172 L Plasmid pRiA4b ORF-3-like protein
COHBPNKO_00974 6.6e-44 yafP 3.6.4.13 K Acetyltransferase (GNAT) domain
COHBPNKO_00975 2.9e-58 S Protein of unknown function (DUF3021)
COHBPNKO_00976 1.2e-71 K LytTr DNA-binding domain
COHBPNKO_00977 5.5e-142 cylB V ABC-2 type transporter
COHBPNKO_00978 8.2e-154 cylA V ABC transporter
COHBPNKO_00979 7.4e-47
COHBPNKO_00980 0.0 XK27_08510 L Type III restriction protein res subunit
COHBPNKO_00981 1.5e-147 S PFAM Archaeal ATPase
COHBPNKO_00982 1.1e-86 3.6.4.12 S PD-(D/E)XK nuclease family transposase
COHBPNKO_00983 1.2e-206 amtB P ammonium transporter
COHBPNKO_00984 8.6e-251 gor 1.8.1.7 C pyridine nucleotide-disulfide oxidoreductase
COHBPNKO_00985 7.7e-48 S B3 4 domain
COHBPNKO_00986 2.1e-33 S B3 4 domain
COHBPNKO_00987 1.5e-89
COHBPNKO_00988 8.8e-124 pnb C nitroreductase
COHBPNKO_00989 4.1e-75 ogt 2.1.1.63 L Methyltransferase
COHBPNKO_00990 4.2e-171 XK27_00915 C Luciferase-like monooxygenase
COHBPNKO_00991 4.3e-42 K helix_turn_helix, mercury resistance
COHBPNKO_00992 1.3e-30 S NAD(P)H dehydrogenase (quinone) activity
COHBPNKO_00993 4.4e-114 Z012_01675 S X-Pro dipeptidyl-peptidase (S15 family)
COHBPNKO_00994 3.3e-37 1.6.5.2 S NAD(P)H dehydrogenase (quinone) activity
COHBPNKO_00995 1.2e-155 3.2.1.96, 3.5.1.28 GH73 M N-acetylmuramoyl-L-alanine amidase
COHBPNKO_00996 3.6e-68 S Protein of unknown function (DUF3021)
COHBPNKO_00997 6.4e-78 K LytTr DNA-binding domain
COHBPNKO_00998 6.3e-22
COHBPNKO_00999 3.5e-203 yhjX P Major Facilitator Superfamily
COHBPNKO_01000 1.9e-119 ybhL S Belongs to the BI1 family
COHBPNKO_01001 6.5e-81 yjcF 3.5.4.33, 4.4.1.8 K protein acetylation
COHBPNKO_01002 4.8e-193 S Protein of unknown function (DUF3114)
COHBPNKO_01003 5.2e-292 gshF 6.3.2.2 H Belongs to the glutamate--cysteine ligase type 1 family
COHBPNKO_01004 3.5e-166 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
COHBPNKO_01005 3.3e-106 yvdD 3.2.2.10 S Belongs to the LOG family
COHBPNKO_01006 9.1e-62 S Domain of unknown function (DUF4828)
COHBPNKO_01007 4.5e-191 mocA S Oxidoreductase
COHBPNKO_01008 5.7e-231 yfmL L DEAD DEAH box helicase
COHBPNKO_01010 3.8e-207 mnaA 5.1.3.14 G Belongs to the UDP-N-acetylglucosamine 2-epimerase family
COHBPNKO_01011 1.4e-56
COHBPNKO_01012 2.3e-67 gtcA S Teichoic acid glycosylation protein
COHBPNKO_01013 1.4e-78 fld C Flavodoxin
COHBPNKO_01014 1.3e-167 map 3.4.11.18 E Methionine Aminopeptidase
COHBPNKO_01015 1.1e-219 arcT 2.6.1.1 E Aminotransferase
COHBPNKO_01016 2.1e-255 E Arginine ornithine antiporter
COHBPNKO_01017 2.4e-281 yjeM E Amino Acid
COHBPNKO_01018 1.6e-152 yihY S Belongs to the UPF0761 family
COHBPNKO_01019 1.9e-33 S Protein of unknown function (DUF2922)
COHBPNKO_01020 4.9e-31
COHBPNKO_01021 9.7e-141 recX 2.4.1.337 GT4 S Regulatory protein RecX
COHBPNKO_01022 5.2e-100 rfbP M Bacterial sugar transferase
COHBPNKO_01023 3.7e-113 cps1D M Domain of unknown function (DUF4422)
COHBPNKO_01024 8.9e-170 yfdH 2.4.2.53 GT2 M Glycosyltransferase, group 2 family protein
COHBPNKO_01025 0.0 2.7.7.6 M Peptidase family M23
COHBPNKO_01026 0.0 G Peptidase_C39 like family
COHBPNKO_01027 2.1e-25
COHBPNKO_01028 9.5e-219 glf 5.4.99.9 M UDP-galactopyranose mutase
COHBPNKO_01029 1.1e-216 rfbX S Membrane protein involved in the export of O-antigen and teichoic acid
COHBPNKO_01030 3.7e-78 rgpB GT2 M Glycosyl transferase family 2
COHBPNKO_01031 3.4e-111 S Glycosyltransferase like family 2
COHBPNKO_01032 4.2e-103 M Glycosyltransferase like family 2
COHBPNKO_01033 2.2e-93 cps3F
COHBPNKO_01034 3.1e-41 M biosynthesis protein
COHBPNKO_01035 7.2e-88 M Domain of unknown function (DUF4422)
COHBPNKO_01036 1.7e-89 S Glycosyltransferase like family
COHBPNKO_01037 2e-24
COHBPNKO_01038 2.6e-82 S Bacterial membrane protein, YfhO
COHBPNKO_01039 8.3e-18 cps3I G Acyltransferase family
COHBPNKO_01040 4e-139 S Psort location CytoplasmicMembrane, score
COHBPNKO_01042 0.0 3.2.1.17 NU Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
COHBPNKO_01043 2.6e-163 rfbA 2.7.7.24 H Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
COHBPNKO_01044 1.6e-108 rfbC 5.1.3.13 M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
COHBPNKO_01045 1.3e-198 rfbB 4.2.1.46 M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
COHBPNKO_01046 9.5e-155 rfbD 1.1.1.133, 5.1.3.13 M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
COHBPNKO_01047 1.7e-283 G Peptidase_C39 like family
COHBPNKO_01048 4.3e-163 yueF S AI-2E family transporter
COHBPNKO_01049 2.1e-88 ygfC K transcriptional regulator (TetR family)
COHBPNKO_01050 1.1e-171 hrtB V ABC transporter permease
COHBPNKO_01051 1.1e-119 devA 3.6.3.25 V ABC transporter, ATP-binding protein
COHBPNKO_01052 0.0 yhcA V ABC transporter, ATP-binding protein
COHBPNKO_01053 1e-37
COHBPNKO_01054 1.2e-49 czrA K Transcriptional regulator, ArsR family
COHBPNKO_01055 6.1e-241 acm2 3.2.1.17 NU Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
COHBPNKO_01056 1.9e-172 scrR K Transcriptional regulator, LacI family
COHBPNKO_01057 1e-24
COHBPNKO_01058 2.5e-107
COHBPNKO_01059 1.3e-213 yttB EGP Major facilitator Superfamily
COHBPNKO_01060 4.4e-244 hisS 6.1.1.21 J histidyl-tRNA synthetase
COHBPNKO_01061 3.5e-88
COHBPNKO_01062 4.6e-109 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX
COHBPNKO_01063 1.6e-263 S Putative peptidoglycan binding domain
COHBPNKO_01064 1.8e-124 yciB M ErfK YbiS YcfS YnhG
COHBPNKO_01066 5.9e-103
COHBPNKO_01067 7.9e-219 dacA 3.4.16.4 M Belongs to the peptidase S11 family
COHBPNKO_01068 7e-126 S Alpha beta hydrolase
COHBPNKO_01069 1.9e-206 gldA 1.1.1.6 C dehydrogenase
COHBPNKO_01070 1.7e-133 ydiN G Major Facilitator Superfamily
COHBPNKO_01071 3.9e-127 aroE 1.1.1.25, 1.1.1.282, 1.3.5.4 E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
COHBPNKO_01072 6.5e-54 aroD 1.1.1.25, 4.2.1.10 E Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
COHBPNKO_01073 1e-12 ydiN 5.4.99.5 G Major Facilitator
COHBPNKO_01074 8.6e-162 aroC 4.2.3.5 E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
COHBPNKO_01075 3.8e-35
COHBPNKO_01076 1.4e-157 aroA 1.3.1.12, 1.3.1.43, 2.5.1.19 E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
COHBPNKO_01077 4.5e-109 tyrA 1.3.1.12, 1.3.1.43 E prephenate dehydrogenase
COHBPNKO_01078 9.1e-36 aroK 1.1.1.25, 2.7.1.71, 4.2.1.10, 4.2.3.4 F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
COHBPNKO_01079 0.0 ltaS 2.7.8.20 M Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
COHBPNKO_01080 1.3e-41
COHBPNKO_01081 6.5e-127 pgm3 3.1.3.73 G phosphoglycerate mutase family
COHBPNKO_01082 4e-284 S C4-dicarboxylate anaerobic carrier
COHBPNKO_01083 1.2e-250 nhaC C Na H antiporter NhaC
COHBPNKO_01084 1.9e-242 pbuX F xanthine permease
COHBPNKO_01085 3.9e-281 pipD E Dipeptidase
COHBPNKO_01086 9.7e-169 corA P CorA-like Mg2+ transporter protein
COHBPNKO_01087 7.7e-166 rluA 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
COHBPNKO_01088 2.3e-131 terC P membrane
COHBPNKO_01089 7.2e-55 trxA O Belongs to the thioredoxin family
COHBPNKO_01090 6.4e-238 mepA V MATE efflux family protein
COHBPNKO_01091 1.6e-91 M domain protein
COHBPNKO_01092 7e-223 L Transposase
COHBPNKO_01093 7.7e-35
COHBPNKO_01094 3.5e-52 S Mazg nucleotide pyrophosphohydrolase
COHBPNKO_01095 3.3e-160 xth 3.1.11.2 L exodeoxyribonuclease III
COHBPNKO_01096 1.5e-83
COHBPNKO_01097 3.6e-188 lacR K Transcriptional regulator
COHBPNKO_01098 0.0 lacS G Transporter
COHBPNKO_01099 0.0 lacZ 3.2.1.23 G -beta-galactosidase
COHBPNKO_01100 1.8e-31
COHBPNKO_01101 3.7e-117 S CAAX protease self-immunity
COHBPNKO_01102 1.9e-43
COHBPNKO_01104 7e-14
COHBPNKO_01105 9.1e-25
COHBPNKO_01106 1.7e-142 S Domain of unknown function DUF1829
COHBPNKO_01107 4.3e-73
COHBPNKO_01108 5.3e-56 folB 1.13.11.81, 2.5.1.15, 2.7.6.3, 4.1.2.25, 5.1.99.8 H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
COHBPNKO_01109 2.7e-91 folK 1.13.11.81, 2.5.1.15, 2.7.6.3, 3.5.4.16, 4.1.2.25, 5.1.99.8 H 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)
COHBPNKO_01110 1.4e-104 folE 2.7.6.3, 3.5.4.16 F GTP cyclohydrolase 1
COHBPNKO_01111 6.7e-229 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
COHBPNKO_01112 5.9e-103 xtp 2.5.1.15, 3.6.1.66 F Ham1 family
COHBPNKO_01113 1.1e-214 folP 2.5.1.15 H dihydropteroate synthase
COHBPNKO_01114 1e-43
COHBPNKO_01115 3.3e-40
COHBPNKO_01117 1.1e-167 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
COHBPNKO_01118 4.7e-151 thiD 2.5.1.3, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Phosphomethylpyrimidine kinase
COHBPNKO_01119 0.0 argS 6.1.1.19 J Arginyl-tRNA synthetase
COHBPNKO_01120 0.0 pbp2A 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
COHBPNKO_01121 9.4e-38 yheA S Belongs to the UPF0342 family
COHBPNKO_01122 2.2e-221 yhaO L Ser Thr phosphatase family protein
COHBPNKO_01123 0.0 L AAA domain
COHBPNKO_01124 3.4e-129 prsA 5.2.1.8 M Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins
COHBPNKO_01126 8.3e-78 hit FG histidine triad
COHBPNKO_01127 5.6e-135 ecsA V ABC transporter, ATP-binding protein
COHBPNKO_01128 1.7e-218 ecsB U ABC transporter
COHBPNKO_01129 1.1e-121 trmB 2.1.1.297, 2.1.1.33 J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
COHBPNKO_01130 5.1e-184 iolS C Aldo keto reductase
COHBPNKO_01131 1.7e-168 glsA 3.5.1.2 E Belongs to the glutaminase family
COHBPNKO_01132 7.5e-58 ytzB S Small secreted protein
COHBPNKO_01133 1.7e-56 ytpP 2.7.1.180, 5.3.4.1 CO Thioredoxin
COHBPNKO_01134 3.2e-118 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
COHBPNKO_01135 7e-48 yafQ S Bacterial toxin of type II toxin-antitoxin system, YafQ
COHBPNKO_01136 1.6e-19 yefM 2.3.1.15 D Antitoxin component of a toxin-antitoxin (TA) module
COHBPNKO_01137 3.4e-252 mpl 6.3.2.4, 6.3.2.45, 6.3.2.8 M Belongs to the MurCDEF family
COHBPNKO_01138 2.5e-119 ybhL S Belongs to the BI1 family
COHBPNKO_01139 7.5e-118 yoaK S Protein of unknown function (DUF1275)
COHBPNKO_01140 0.0 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
COHBPNKO_01141 2e-160 fpg 3.2.2.23, 4.2.99.18 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
COHBPNKO_01142 1.5e-101 coaE 2.7.1.24 F Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
COHBPNKO_01143 1.1e-80 nrdR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
COHBPNKO_01144 6.8e-203 dnaB L replication initiation and membrane attachment
COHBPNKO_01145 8.1e-171 dnaI L Primosomal protein DnaI
COHBPNKO_01146 3.7e-85 infC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
COHBPNKO_01147 2.3e-27 rpmI J Belongs to the bacterial ribosomal protein bL35 family
COHBPNKO_01148 3.3e-56 rplT J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
COHBPNKO_01149 4.8e-96 yqeG S HAD phosphatase, family IIIA
COHBPNKO_01150 1.1e-217 yqeH S Ribosome biogenesis GTPase YqeH
COHBPNKO_01151 1.9e-47 yhbY J RNA-binding protein
COHBPNKO_01152 7.4e-123 nadD 2.7.7.18, 3.6.1.55 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
COHBPNKO_01153 3.3e-112 nadD 2.7.6.3, 2.7.7.18 H Hydrolase, HD family
COHBPNKO_01154 4.9e-60 rsfS J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
COHBPNKO_01155 4.2e-138 yqeM Q Methyltransferase
COHBPNKO_01156 6.1e-213 ylbM S Belongs to the UPF0348 family
COHBPNKO_01157 2.9e-99 yceD S Uncharacterized ACR, COG1399
COHBPNKO_01158 3.3e-28 rpmF J Belongs to the bacterial ribosomal protein bL32 family
COHBPNKO_01159 1.5e-121 K response regulator
COHBPNKO_01160 4.1e-278 arlS 2.7.13.3 T Histidine kinase
COHBPNKO_01161 4.3e-267 yjeM E Amino Acid
COHBPNKO_01162 1e-232 V MatE
COHBPNKO_01163 2.5e-68 def_1 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins
COHBPNKO_01164 1.5e-169 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
COHBPNKO_01165 2e-45 acyP 3.6.1.7 C Belongs to the acylphosphatase family
COHBPNKO_01166 2.2e-145 spoU 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
COHBPNKO_01167 3.1e-92 XK27_09705 6.1.1.14 S Metal dependent phosphohydrolases with conserved 'HD' motif.
COHBPNKO_01168 6.7e-59 yodB K Transcriptional regulator, HxlR family
COHBPNKO_01169 6.6e-198 pheS 6.1.1.20 J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
COHBPNKO_01170 0.0 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
COHBPNKO_01171 3e-116 rlpA M PFAM NLP P60 protein
COHBPNKO_01172 2.5e-118 udk 2.7.1.48 F Cytidine monophosphokinase
COHBPNKO_01173 1.4e-78 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
COHBPNKO_01174 8.8e-71 yneR S Belongs to the HesB IscA family
COHBPNKO_01175 0.0 S membrane
COHBPNKO_01176 0.0 pbp2b 3.4.16.4 M Penicillin-binding Protein
COHBPNKO_01177 4.2e-21 rpmG J Belongs to the bacterial ribosomal protein bL33 family
COHBPNKO_01178 1.3e-99 ygfA 6.3.3.2 H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
COHBPNKO_01179 2.4e-113 gluP 3.4.21.105 S Peptidase, S54 family
COHBPNKO_01180 7.4e-36 yqgQ S Bacterial protein of unknown function (DUF910)
COHBPNKO_01181 1.5e-183 glk 2.7.1.2 G Glucokinase
COHBPNKO_01182 1.3e-66 yqhL P Rhodanese-like protein
COHBPNKO_01183 5.9e-22 S Protein of unknown function (DUF3042)
COHBPNKO_01184 3.1e-175 miaA 2.5.1.75 F Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
COHBPNKO_01185 3.1e-264 glnA 6.3.1.2 E glutamine synthetase
COHBPNKO_01186 5.3e-297 gltX 6.1.1.17, 6.1.1.24 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
COHBPNKO_01187 3.2e-217 patA 2.6.1.1, 2.6.1.57 E Aminotransferase
COHBPNKO_01188 3.9e-12
COHBPNKO_01189 1.9e-155 P Belongs to the nlpA lipoprotein family
COHBPNKO_01190 1.4e-100 msrA 1.8.4.11, 1.8.4.12 C Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
COHBPNKO_01191 1.4e-50 S Iron-sulfur cluster assembly protein
COHBPNKO_01192 1e-151
COHBPNKO_01193 4.1e-184
COHBPNKO_01194 1.9e-89 dut S Protein conserved in bacteria
COHBPNKO_01197 2.6e-112 K Transcriptional regulator
COHBPNKO_01198 5.2e-50 rplU J This protein binds to 23S rRNA in the presence of protein L20
COHBPNKO_01199 6.2e-54 ysxB J Cysteine protease Prp
COHBPNKO_01200 2.1e-45 rpmA J Belongs to the bacterial ribosomal protein bL27 family
COHBPNKO_01201 8.6e-133 yggS S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
COHBPNKO_01202 6.6e-201 pepP 3.4.11.9, 3.4.13.9 E Creatinase/Prolidase N-terminal domain
COHBPNKO_01203 1.7e-114 J 2'-5' RNA ligase superfamily
COHBPNKO_01204 2.2e-70 yqhY S Asp23 family, cell envelope-related function
COHBPNKO_01205 1.2e-70 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
COHBPNKO_01206 9.5e-150 folD 1.5.1.5, 3.5.4.9 F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
COHBPNKO_01207 2.6e-215 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
COHBPNKO_01208 4.3e-43 xseB 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
COHBPNKO_01209 3.9e-159 ispA 2.5.1.1, 2.5.1.10, 2.5.1.29, 2.5.1.90 H Belongs to the FPP GGPP synthase family
COHBPNKO_01210 3.1e-150 rrmJ 2.1.1.226, 2.1.1.227 J Ribosomal RNA large subunit methyltransferase J
COHBPNKO_01211 1.1e-77 argR K Regulates arginine biosynthesis genes
COHBPNKO_01212 3.3e-263 recN L May be involved in recombinational repair of damaged DNA
COHBPNKO_01213 1.7e-54
COHBPNKO_01214 4.2e-115 gmk 2.7.4.8 F Essential for recycling GMP and indirectly, cGMP
COHBPNKO_01215 7.7e-32 rpoZ 2.7.7.6 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
COHBPNKO_01216 1.8e-215 coaBC 4.1.1.36, 6.3.2.5 H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
COHBPNKO_01217 0.0 priA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
COHBPNKO_01218 3.6e-174 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
COHBPNKO_01219 3.7e-249 sun 2.1.1.176 J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
COHBPNKO_01220 2.9e-131 stp 3.1.3.16 T phosphatase
COHBPNKO_01221 0.0 KLT serine threonine protein kinase
COHBPNKO_01222 2.8e-165 rsgA 3.1.3.100 S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
COHBPNKO_01223 5.5e-118 rpe 5.1.3.1 G Belongs to the ribulose-phosphate 3-epimerase family
COHBPNKO_01224 3.1e-121 thiN 2.7.6.2 H thiamine pyrophosphokinase
COHBPNKO_01225 4.6e-25 rpmB J Belongs to the bacterial ribosomal protein bL28 family
COHBPNKO_01226 4.7e-58 asp S Asp23 family, cell envelope-related function
COHBPNKO_01227 0.0 yloV S DAK2 domain fusion protein YloV
COHBPNKO_01228 0.0 recG 3.6.4.12 L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
COHBPNKO_01229 1.6e-188 plsX 2.3.1.15 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
COHBPNKO_01230 2.9e-38 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
COHBPNKO_01231 4.2e-132 rnc 3.1.26.3 J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
COHBPNKO_01232 0.0 smc D Required for chromosome condensation and partitioning
COHBPNKO_01233 7.7e-179 ftsY U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
COHBPNKO_01234 8.3e-57 ylxM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
COHBPNKO_01235 7.9e-250 ffh 3.6.5.4 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
COHBPNKO_01236 2.2e-44 rpsP J Belongs to the bacterial ribosomal protein bS16 family
COHBPNKO_01237 7.8e-39 ylqC S Belongs to the UPF0109 family
COHBPNKO_01238 6.9e-92 rimM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
COHBPNKO_01239 9.9e-143 trmD 2.1.1.228, 4.6.1.12 J Belongs to the RNA methyltransferase TrmD family
COHBPNKO_01240 1.7e-260 yfnA E amino acid
COHBPNKO_01241 2.5e-59 rplS J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
COHBPNKO_01242 2.2e-200 L Transposase
COHBPNKO_01243 1.2e-217 htrA 3.4.21.107 O serine protease
COHBPNKO_01244 4.5e-154 vicX 3.1.26.11 S domain protein
COHBPNKO_01245 1.4e-150 yycI S YycH protein
COHBPNKO_01246 2.1e-249 yycH S YycH protein
COHBPNKO_01247 0.0 vicK 2.7.13.3 T Histidine kinase
COHBPNKO_01248 3.1e-130 K response regulator
COHBPNKO_01250 1.4e-309 lmrA 3.6.3.44 V ABC transporter
COHBPNKO_01251 4.7e-73 K helix_turn_helix multiple antibiotic resistance protein
COHBPNKO_01253 1.3e-123 Z012_01130 S Fic/DOC family
COHBPNKO_01254 4.3e-158 S Polyphosphate nucleotide phosphotransferase, PPK2 family
COHBPNKO_01255 3.2e-58
COHBPNKO_01256 6.4e-205 yttB EGP Major facilitator Superfamily
COHBPNKO_01257 2.2e-233 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
COHBPNKO_01258 2e-74 rplI J Binds to the 23S rRNA
COHBPNKO_01259 0.0 yybT T signaling protein consisting of a modified GGDEF domain and a DHH domain
COHBPNKO_01260 3.6e-102 deoR K sugar-binding domain protein
COHBPNKO_01261 3.9e-95 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
COHBPNKO_01262 0.0 gtfC 2.4.1.5 GH13 G Glycosyl hydrolase family 70
COHBPNKO_01263 5.3e-283 2.4.1.5 GH13 G Glycosyl hydrolase family 70
COHBPNKO_01264 4.6e-99 busR K UTRA
COHBPNKO_01265 8.4e-166 yegU O ADP-ribosylglycohydrolase
COHBPNKO_01266 5.4e-240 F Belongs to the purine-cytosine permease (2.A.39) family
COHBPNKO_01267 3.4e-118 G Belongs to the carbohydrate kinase PfkB family
COHBPNKO_01268 2.9e-27 L Reverse transcriptase (RNA-dependent DNA polymerase)
COHBPNKO_01269 1.6e-174 L Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
COHBPNKO_01270 1.4e-161 akr5f 1.1.1.346 S reductase
COHBPNKO_01271 2.8e-157 K Transcriptional regulator
COHBPNKO_01272 4.7e-185 ansA 3.5.1.1 EJ L-asparaginase, type I
COHBPNKO_01273 5.4e-165 ypuA S Protein of unknown function (DUF1002)
COHBPNKO_01274 6.8e-65 GM NAD(P)H-binding
COHBPNKO_01275 5.9e-94 padR K Virulence activator alpha C-term
COHBPNKO_01276 2.7e-94 padC Q Phenolic acid decarboxylase
COHBPNKO_01277 6.5e-151 S Alpha beta hydrolase
COHBPNKO_01278 3.3e-135 S Hydrolases of the alpha beta superfamily
COHBPNKO_01279 6.3e-88 lacA S transferase hexapeptide repeat
COHBPNKO_01280 4e-148 K Transcriptional regulator
COHBPNKO_01281 1.1e-250 L PFAM transposase, IS4 family protein
COHBPNKO_01282 1.6e-174 L Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
COHBPNKO_01283 5.3e-102 fhaB M Rib/alpha-like repeat
COHBPNKO_01284 1.6e-174 L Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
COHBPNKO_01285 2.2e-293 L Transposase
COHBPNKO_01286 1.6e-174 L Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
COHBPNKO_01287 5.1e-78 UW LPXTG-motif cell wall anchor domain protein
COHBPNKO_01288 1.7e-173 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 G Responsible for synthesis of pseudouridine from uracil
COHBPNKO_01289 2.7e-154 nadK 2.7.1.23 F Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
COHBPNKO_01290 5.2e-116 yjbM 2.7.6.5 S RelA SpoT domain protein
COHBPNKO_01291 4.7e-114 yjbH Q Thioredoxin
COHBPNKO_01292 1e-262 pipD E Dipeptidase
COHBPNKO_01293 2.2e-201 coiA 3.6.4.12 S Competence protein
COHBPNKO_01294 7e-223 L Transposase
COHBPNKO_01295 2.7e-132 fabI 1.3.1.10, 1.3.1.9 I Enoyl- acyl-carrier-protein reductase NADH
COHBPNKO_01296 4e-139 accA 2.1.3.15, 6.4.1.2 I alpha subunit
COHBPNKO_01297 3.2e-142 accD 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
COHBPNKO_01298 6.8e-259 accC 6.3.4.14, 6.4.1.2 I Acetyl-CoA carboxylase biotin carboxylase subunit
COHBPNKO_01299 3.9e-75 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
COHBPNKO_01300 1.2e-74 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
COHBPNKO_01301 1.5e-225 fabF 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
COHBPNKO_01302 1.7e-128 IQ reductase
COHBPNKO_01303 9.7e-156 fabD 2.3.1.39 I Malonyl CoA-acyl carrier protein transacylase
COHBPNKO_01304 6.5e-35 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
COHBPNKO_01305 7.9e-177 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
COHBPNKO_01306 4.2e-77 marR K Transcriptional regulator, MarR family
COHBPNKO_01307 1.9e-71 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
COHBPNKO_01309 1.3e-201 xerS L Belongs to the 'phage' integrase family
COHBPNKO_01310 4.3e-237 sacB 2.4.1.10, 2.4.1.9, 3.2.1.26 GH32,GH68 M Levansucrase/Invertase
COHBPNKO_01311 5e-159 rssA S Phospholipase, patatin family
COHBPNKO_01312 2.5e-118 L Integrase
COHBPNKO_01313 3.8e-154 EG EamA-like transporter family
COHBPNKO_01314 1.9e-129 narI 1.7.5.1 C Nitrate reductase
COHBPNKO_01315 3.9e-99 narJ C nitrate reductase molybdenum cofactor assembly chaperone
COHBPNKO_01316 0.0 narH 1.7.5.1 C 4Fe-4S dicluster domain
COHBPNKO_01317 0.0 narG 1.7.5.1 C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
COHBPNKO_01318 7.7e-183 moeB 2.7.7.73, 2.7.7.80 H ThiF family
COHBPNKO_01319 3.6e-85 moaB 2.7.7.75 H May be involved in the biosynthesis of molybdopterin
COHBPNKO_01320 2.8e-224 moeA 2.10.1.1 H MoeA N-terminal region (domain I and II)
COHBPNKO_01321 7.5e-75 mobB 2.10.1.1, 2.7.7.77 H molybdopterin-guanine dinucleotide biosynthesis protein
COHBPNKO_01322 3.7e-94 mobA 2.7.7.77 H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
COHBPNKO_01323 6.3e-42
COHBPNKO_01324 2.3e-182 comP 2.7.13.3 F Sensor histidine kinase
COHBPNKO_01325 4.9e-114 nreC K PFAM regulatory protein LuxR
COHBPNKO_01326 2.7e-18
COHBPNKO_01327 7.3e-175
COHBPNKO_01328 9.7e-145 hepT 2.5.1.30, 2.5.1.90 H geranyltranstransferase activity
COHBPNKO_01329 2.3e-215 narK P Transporter, major facilitator family protein
COHBPNKO_01330 8.7e-32 moaD 2.8.1.12 H ThiS family
COHBPNKO_01331 1.2e-62 moaE 2.8.1.12 H MoaE protein
COHBPNKO_01332 1e-78 S Flavodoxin
COHBPNKO_01333 8.6e-128 fecD P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
COHBPNKO_01334 5e-126 fecE 3.6.3.34 HP AAA domain, putative AbiEii toxin, Type IV TA system
COHBPNKO_01335 1.5e-173 fecB P Periplasmic binding protein
COHBPNKO_01336 3.3e-175
COHBPNKO_01337 1.2e-76
COHBPNKO_01338 2.9e-114 flp 4.1.99.16, 4.2.3.22, 4.2.3.75 K Transcriptional regulator, Crp Fnr family
COHBPNKO_01339 0.0 S SEC-C Motif Domain Protein
COHBPNKO_01340 3.6e-51
COHBPNKO_01341 1.7e-140 thiM 2.7.1.50 H Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
COHBPNKO_01342 8.4e-148 thiD 2.5.1.3, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Phosphomethylpyrimidine kinase
COHBPNKO_01343 2.1e-117 thiE 2.5.1.3 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
COHBPNKO_01344 1e-229 clcA_2 P Chloride transporter, ClC family
COHBPNKO_01345 0.0 malZ 3.2.1.20 GH31 G Belongs to the glycosyl hydrolase 31 family
COHBPNKO_01346 6.4e-111 lssY 3.6.1.27 I Acid phosphatase homologues
COHBPNKO_01347 7e-223 L Transposase
COHBPNKO_01349 8.8e-15
COHBPNKO_01350 2.6e-242 glpT G Major Facilitator Superfamily
COHBPNKO_01351 2.1e-103 clpP 3.4.21.92 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
COHBPNKO_01353 1.1e-189 gap 1.2.1.12 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
COHBPNKO_01354 2.4e-228 pgk 2.7.2.3, 5.3.1.1 F Belongs to the phosphoglycerate kinase family
COHBPNKO_01355 4.8e-142 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
COHBPNKO_01356 4.2e-250 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
COHBPNKO_01357 3.3e-245 yifK E Amino acid permease
COHBPNKO_01358 1.7e-290 clcA P chloride
COHBPNKO_01359 5.3e-34 secG U Preprotein translocase
COHBPNKO_01360 6.8e-147 est 3.1.1.1 S Serine aminopeptidase, S33
COHBPNKO_01361 0.0 rnr J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
COHBPNKO_01362 4.2e-83 smpB J the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
COHBPNKO_01363 3.7e-105 yxjI
COHBPNKO_01364 4e-135 ung 3.2.2.27 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
COHBPNKO_01365 3.8e-179 pta 2.3.1.8, 3.6.3.21 C phosphate acetyltransferase
COHBPNKO_01366 2.2e-81 ydiB 2.7.1.221, 5.1.1.1 O Hydrolase, P-loop family
COHBPNKO_01367 3e-87 K Acetyltransferase (GNAT) domain
COHBPNKO_01368 6.8e-77 S PAS domain
COHBPNKO_01369 2.7e-102 dnaQ 2.7.7.7 L DNA polymerase III
COHBPNKO_01370 4.7e-168 murB 1.3.1.98 M Cell wall formation
COHBPNKO_01371 2.7e-166 rbsK 2.7.1.15 H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
COHBPNKO_01372 1e-66 rbsD 5.4.99.62 G Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose
COHBPNKO_01373 4.8e-249 fucP G Major Facilitator Superfamily
COHBPNKO_01374 5e-151 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
COHBPNKO_01375 2e-126 ybbR S YbbR-like protein
COHBPNKO_01376 3.2e-253 glmM 5.4.2.10 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
COHBPNKO_01377 0.0 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
COHBPNKO_01378 8.7e-53
COHBPNKO_01379 0.0 oatA I Acyltransferase
COHBPNKO_01380 2.3e-81 K Transcriptional regulator
COHBPNKO_01381 7.5e-149 XK27_02985 S Cof-like hydrolase
COHBPNKO_01382 2.8e-79 lytE M Lysin motif
COHBPNKO_01384 5.1e-133 K response regulator
COHBPNKO_01385 2.4e-273 yclK 2.7.13.3 T Histidine kinase
COHBPNKO_01386 3.4e-155 glcU U sugar transport
COHBPNKO_01387 2e-101 lacA 2.3.1.79 S Transferase hexapeptide repeat
COHBPNKO_01388 1.3e-262 pgi 5.3.1.9 G Belongs to the GPI family
COHBPNKO_01389 1.3e-28
COHBPNKO_01390 2.5e-217 xylR GK ROK family
COHBPNKO_01392 7e-223 L Transposase
COHBPNKO_01393 1.2e-146 holA 2.7.7.7 L DNA polymerase III delta subunit
COHBPNKO_01394 0.0 comEC S Competence protein ComEC
COHBPNKO_01395 1.2e-88 comEB 3.5.4.12 F ComE operon protein 2
COHBPNKO_01396 5.2e-81 comEA L Competence protein ComEA
COHBPNKO_01397 4.6e-199 ylbL T Belongs to the peptidase S16 family
COHBPNKO_01398 1.1e-89 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
COHBPNKO_01399 1.4e-98 rsmD 2.1.1.171 L RNA methyltransferase, RsmD family
COHBPNKO_01400 3.9e-44 ylbG S Uncharacterized protein conserved in bacteria (DUF2129)
COHBPNKO_01401 1.2e-222 ftsW D Belongs to the SEDS family
COHBPNKO_01402 0.0 typA T GTP-binding protein TypA
COHBPNKO_01403 9.1e-136 suhB 3.1.3.25 G Belongs to the inositol monophosphatase superfamily
COHBPNKO_01404 3e-47 yktA S Belongs to the UPF0223 family
COHBPNKO_01405 1.4e-275 lpdA 1.8.1.4 C Dehydrogenase
COHBPNKO_01406 1e-227 pdhC 2.3.1.12 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
COHBPNKO_01407 8.1e-182 pdhB 1.2.4.1 C Transketolase, C-terminal domain protein
COHBPNKO_01408 2e-208 pdhA 1.2.4.1, 1.2.4.4 C Dehydrogenase E1 component
COHBPNKO_01409 1.3e-102 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
COHBPNKO_01410 3.6e-82
COHBPNKO_01411 9.8e-32 ykzG S Belongs to the UPF0356 family
COHBPNKO_01412 3.8e-184 ytlR 2.7.1.91 I Diacylglycerol kinase catalytic
COHBPNKO_01413 5.7e-29
COHBPNKO_01414 1.4e-134 mltD CBM50 M NlpC P60 family protein
COHBPNKO_01416 2.2e-57
COHBPNKO_01417 5.1e-207 glxK 2.7.1.165 G Belongs to the glycerate kinase type-1 family
COHBPNKO_01418 5.9e-220 EG GntP family permease
COHBPNKO_01419 1.4e-83 KT Putative sugar diacid recognition
COHBPNKO_01420 2e-197 asd 1.2.1.11 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
COHBPNKO_01421 4.5e-219 patA 2.6.1.1 E Aminotransferase
COHBPNKO_01422 1.8e-139 dapB 1.17.1.8 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
COHBPNKO_01423 1.2e-174 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
COHBPNKO_01424 5.5e-222 hipO 3.5.1.47 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
COHBPNKO_01425 5.7e-76 dapD 2.3.1.117, 2.3.1.89 E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
COHBPNKO_01426 2.7e-249 lysA 4.1.1.19, 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
COHBPNKO_01427 3.6e-260 lysC 2.7.2.4 E Belongs to the aspartokinase family
COHBPNKO_01428 6.4e-174 dapF 5.1.1.7 E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
COHBPNKO_01429 8.1e-174 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
COHBPNKO_01430 0.0 recD2 3.1.11.5 L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
COHBPNKO_01431 9e-119 S Repeat protein
COHBPNKO_01432 1.1e-121 pgm6 5.4.2.11, 5.4.2.12 G phosphoglycerate mutase
COHBPNKO_01433 1.8e-225 mnmA 2.8.1.13 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
COHBPNKO_01434 7.5e-58 XK27_04120 S Putative amino acid metabolism
COHBPNKO_01435 5.4e-217 iscS 2.8.1.7 E Aminotransferase class V
COHBPNKO_01436 1e-125 mtnN 3.2.2.9 E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
COHBPNKO_01438 3.2e-98 nudF 3.6.1.13 L ADP-ribose pyrophosphatase
COHBPNKO_01439 4.2e-32 cspA K Cold shock protein
COHBPNKO_01440 0.0 ileS 6.1.1.5 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
COHBPNKO_01441 2.5e-42 divIVA D DivIVA domain protein
COHBPNKO_01442 1.9e-144 ylmH S S4 domain protein
COHBPNKO_01443 3.2e-40 yggT S YGGT family
COHBPNKO_01444 9.4e-71 sepF D Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
COHBPNKO_01445 5.3e-226 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
COHBPNKO_01446 2.9e-254 ftsA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
COHBPNKO_01447 1.8e-145 divIB D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
COHBPNKO_01448 2.3e-204 murG 2.4.1.227, 6.3.2.8 GT28 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
COHBPNKO_01449 3.8e-262 murD 6.3.2.9 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
COHBPNKO_01450 2.6e-180 mraY 2.7.8.13 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
COHBPNKO_01451 0.0 ftsI 3.4.16.4 M Penicillin-binding Protein
COHBPNKO_01452 1.5e-56 ftsL D Cell division protein FtsL
COHBPNKO_01453 1e-173 rsmH 2.1.1.199 J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
COHBPNKO_01454 3.1e-77 mraZ K Belongs to the MraZ family
COHBPNKO_01455 1.7e-57
COHBPNKO_01456 1.2e-10 S Protein of unknown function (DUF4044)
COHBPNKO_01457 0.0 ftsK D Belongs to the FtsK SpoIIIE SftA family
COHBPNKO_01458 1e-95 trmL 2.1.1.207 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
COHBPNKO_01459 2.9e-159 rrmA 2.1.1.187 H Methyltransferase
COHBPNKO_01460 1.3e-182 pgl 3.1.1.31 G Lactonase, 7-bladed beta-propeller
COHBPNKO_01462 1.7e-65 XK27_01125 L PFAM IS66 Orf2 family protein
COHBPNKO_01463 7e-223 L Transposase
COHBPNKO_01464 1.9e-272 menE 6.2.1.26 H Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily
COHBPNKO_01465 5.8e-157 menB 4.1.3.36 H Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
COHBPNKO_01466 4.2e-62 ydiI Q Thioesterase superfamily
COHBPNKO_01467 2.4e-109 yvrI K sigma factor activity
COHBPNKO_01468 5e-202 G Transporter, major facilitator family protein
COHBPNKO_01469 0.0 S Bacterial membrane protein YfhO
COHBPNKO_01470 1.5e-103 T Ion transport 2 domain protein
COHBPNKO_01471 3.9e-78 ribH 2.5.1.78 H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
COHBPNKO_01472 2.3e-223 ribBA 3.5.4.25, 4.1.99.12 H Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate
COHBPNKO_01473 1.1e-99 ribE 2.5.1.9, 3.5.4.25, 4.1.99.12 H Riboflavin synthase
COHBPNKO_01474 7.7e-186 ribD 1.1.1.193, 3.5.4.26 H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
COHBPNKO_01475 5.6e-180 rihA 3.2.2.1 F Inosine-uridine preferring nucleoside hydrolase
COHBPNKO_01477 0.0 L PLD-like domain
COHBPNKO_01478 1.9e-21
COHBPNKO_01479 7.7e-33 higA K addiction module antidote protein HigA
COHBPNKO_01481 1.8e-57 yhaI S Protein of unknown function (DUF805)
COHBPNKO_01482 2.2e-44
COHBPNKO_01483 0.0 nylA 3.5.1.4 J Belongs to the amidase family
COHBPNKO_01484 4.2e-47
COHBPNKO_01485 2.2e-96 K Acetyltransferase (GNAT) domain
COHBPNKO_01486 3.8e-295 gntK 2.7.1.12, 2.7.1.17 G Belongs to the FGGY kinase family
COHBPNKO_01487 1.3e-233 gntT EG Gluconate
COHBPNKO_01488 5.1e-187 K Transcriptional regulator, LacI family
COHBPNKO_01489 4.1e-289 gntK 2.7.1.12, 2.7.1.17 G Belongs to the FGGY kinase family
COHBPNKO_01490 1.2e-94
COHBPNKO_01491 2.3e-24
COHBPNKO_01492 8.7e-63 asp S Asp23 family, cell envelope-related function
COHBPNKO_01493 1.3e-90 ywnH 2.3.1.183 M Acetyltransferase (GNAT) domain
COHBPNKO_01495 2.7e-49
COHBPNKO_01496 2.4e-68 yqkB S Belongs to the HesB IscA family
COHBPNKO_01497 2.3e-173 ppaC 3.6.1.1 C inorganic pyrophosphatase
COHBPNKO_01498 1.1e-83 F NUDIX domain
COHBPNKO_01499 0.0 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
COHBPNKO_01500 0.0 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
COHBPNKO_01501 1.5e-107 plsY 2.3.1.15, 3.5.1.104 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
COHBPNKO_01502 1.7e-170 lacX 5.1.3.3 G Aldose 1-epimerase
COHBPNKO_01503 0.0 topA 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
COHBPNKO_01504 2.4e-161 dprA LU DNA protecting protein DprA
COHBPNKO_01505 1.4e-141 rnhB 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
COHBPNKO_01506 8.4e-162 ylqF S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
COHBPNKO_01507 4.4e-35 yozE S Belongs to the UPF0346 family
COHBPNKO_01508 1.6e-108 ypmS S Uncharacterized protein conserved in bacteria (DUF2140)
COHBPNKO_01509 4.7e-171 ypmR E lipolytic protein G-D-S-L family
COHBPNKO_01510 4.4e-152 DegV S EDD domain protein, DegV family
COHBPNKO_01511 5.3e-113 hlyIII S protein, hemolysin III
COHBPNKO_01512 1.5e-91 folA 1.5.1.3 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
COHBPNKO_01513 1e-192 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
COHBPNKO_01514 0.0 yfmR S ABC transporter, ATP-binding protein
COHBPNKO_01515 1.5e-225 cca 2.7.7.19, 2.7.7.72 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
COHBPNKO_01516 7.4e-236 S Tetratricopeptide repeat protein
COHBPNKO_01517 2.6e-40 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
COHBPNKO_01518 7.2e-250 der 1.1.1.399, 1.1.1.95 S GTPase that plays an essential role in the late steps of ribosome biogenesis
COHBPNKO_01519 1.4e-205 rpsA 1.17.7.4 J Ribosomal protein S1
COHBPNKO_01520 3.4e-118 cmk 1.17.7.4, 2.5.1.19, 2.7.1.26, 2.7.4.25, 2.7.7.2, 6.3.2.1 F Belongs to the cytidylate kinase family. Type 1 subfamily
COHBPNKO_01521 8.5e-14 M Lysin motif
COHBPNKO_01522 1.8e-270 recQ1 3.6.4.12 L ATP-dependent DNA helicase RecQ
COHBPNKO_01523 3.1e-192 ypbB 5.1.3.1 S Helix-turn-helix domain
COHBPNKO_01524 2e-103 U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
COHBPNKO_01525 5.8e-129 rluB 5.4.99.19, 5.4.99.21, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
COHBPNKO_01526 2.2e-105 scpB D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
COHBPNKO_01527 2.6e-138 scpA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
COHBPNKO_01528 5.6e-64 ribT K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
COHBPNKO_01529 5.7e-166 xerD D recombinase XerD
COHBPNKO_01530 9.3e-169 cvfB S S1 domain
COHBPNKO_01531 2.1e-271 pyk 2.7.1.40, 2.7.7.4 G Belongs to the pyruvate kinase family
COHBPNKO_01532 0.0 dnaE 2.7.7.7 L DNA polymerase
COHBPNKO_01533 2.3e-30 S Protein of unknown function (DUF2929)
COHBPNKO_01534 2.1e-235 pepT 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
COHBPNKO_01535 1.5e-157 yqfO 3.5.4.16 S Belongs to the GTP cyclohydrolase I type 2 NIF3 family
COHBPNKO_01536 8.4e-128 trmK 2.1.1.217 S SAM-dependent methyltransferase
COHBPNKO_01537 4.8e-221 patA 2.6.1.1 E Aminotransferase
COHBPNKO_01538 1.7e-207 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
COHBPNKO_01539 0.0 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
COHBPNKO_01540 0.0 glyS 6.1.1.14 J Glycyl-tRNA synthetase beta subunit
COHBPNKO_01541 2e-180 glyQ 6.1.1.14 J glycyl-tRNA synthetase alpha subunit
COHBPNKO_01542 2.6e-146 recO L Involved in DNA repair and RecF pathway recombination
COHBPNKO_01543 5.1e-170 era S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
COHBPNKO_01544 5.8e-62 dgkA 2.7.1.107, 2.7.1.66 M Diacylglycerol kinase
COHBPNKO_01545 2.1e-82 ybeY 2.6.99.2, 3.5.4.5 S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
COHBPNKO_01546 2e-183 phoH T phosphate starvation-inducible protein PhoH
COHBPNKO_01547 4.6e-177 birA 6.3.4.15 H Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
COHBPNKO_01548 5.6e-90 bioY S BioY family
COHBPNKO_01549 4.6e-263 argH 4.3.2.1 E argininosuccinate lyase
COHBPNKO_01550 8.6e-237 argG 6.3.4.5 E Belongs to the argininosuccinate synthase family. Type 1 subfamily
COHBPNKO_01551 5.1e-184 cbh 3.5.1.24 M Linear amide C-N hydrolase, choloylglycine hydrolase family protein
COHBPNKO_01552 2.3e-54 yqeY S YqeY-like protein
COHBPNKO_01553 1.2e-23 rpsU J Belongs to the bacterial ribosomal protein bS21 family
COHBPNKO_01554 1.1e-265 glnPH2 P ABC transporter permease
COHBPNKO_01555 6.9e-133 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
COHBPNKO_01556 0.0 aspS 6.1.1.12 J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
COHBPNKO_01557 3.1e-169 yniA G Phosphotransferase enzyme family
COHBPNKO_01558 5.4e-77 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
COHBPNKO_01559 0.0 relA 2.7.6.5 KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
COHBPNKO_01560 1.5e-50
COHBPNKO_01561 6.1e-129 rsmE 2.1.1.193 J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
COHBPNKO_01562 1.3e-176 prmA J Ribosomal protein L11 methyltransferase
COHBPNKO_01563 2.8e-57
COHBPNKO_01565 2.3e-173 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
COHBPNKO_01566 1.4e-198 mdh 1.1.1.350 C Belongs to the LDH2 MDH2 oxidoreductase family
COHBPNKO_01567 9.1e-275 pipD E Dipeptidase
COHBPNKO_01568 1e-23 S Coenzyme PQQ synthesis protein D (PqqD)
COHBPNKO_01569 2.5e-198 S OPT oligopeptide transporter protein
COHBPNKO_01570 0.0 lepA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
COHBPNKO_01572 1.1e-35 S Metallo-beta-lactamase superfamily
COHBPNKO_01573 5.1e-199 dnaJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
COHBPNKO_01574 0.0 dnaK O Heat shock 70 kDa protein
COHBPNKO_01575 3.9e-75 grpE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
COHBPNKO_01576 1.8e-195 hrcA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
COHBPNKO_01577 3.8e-63
COHBPNKO_01578 2.2e-176 ribF 2.7.1.26, 2.7.7.2 H Belongs to the ribF family
COHBPNKO_01579 1.8e-167 truB 5.4.99.25 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
COHBPNKO_01580 2.1e-58 rbfA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
COHBPNKO_01581 0.0 infB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
COHBPNKO_01582 3.8e-48 ylxQ J ribosomal protein
COHBPNKO_01583 1e-44 ylxR K Protein of unknown function (DUF448)
COHBPNKO_01584 1e-215 nusA K Participates in both transcription termination and antitermination
COHBPNKO_01585 2.5e-83 rimP J Required for maturation of 30S ribosomal subunits
COHBPNKO_01586 0.0 polC 2.7.7.7 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
COHBPNKO_01587 0.0 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
COHBPNKO_01588 3.7e-235 rseP 3.4.21.107, 3.4.21.116 M zinc metalloprotease
COHBPNKO_01589 5.8e-138 cdsA 2.7.7.41 I Belongs to the CDS family
COHBPNKO_01590 3.5e-140 uppS 2.5.1.31 H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
COHBPNKO_01591 7.4e-230 L transposase, IS605 OrfB family
COHBPNKO_01592 2.1e-60 L PFAM transposase IS200-family protein
COHBPNKO_01593 4.8e-94 frr J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
COHBPNKO_01594 1.7e-129 pyrH 2.7.4.22 F Catalyzes the reversible phosphorylation of UMP to UDP
COHBPNKO_01595 2.4e-153 tsf J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
COHBPNKO_01596 1.2e-143 rpsB J Belongs to the universal ribosomal protein uS2 family
COHBPNKO_01597 1.8e-181 ldhD 1.1.1.28 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
COHBPNKO_01598 1.6e-48 yazA L GIY-YIG catalytic domain protein
COHBPNKO_01599 1.9e-141 yabB 2.1.1.223 L Methyltransferase small domain
COHBPNKO_01600 1.6e-117 plsC 2.3.1.51 I Acyltransferase
COHBPNKO_01601 9.8e-30 yneF S Uncharacterised protein family (UPF0154)
COHBPNKO_01602 1.3e-35 ynzC S UPF0291 protein
COHBPNKO_01603 5.5e-115 lexA 3.4.21.88 K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
COHBPNKO_01604 5.2e-212 mvaS 2.3.3.10 I Hydroxymethylglutaryl-CoA synthase
COHBPNKO_01605 6.3e-125 rnhA 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
COHBPNKO_01609 3.2e-18
COHBPNKO_01611 1.6e-79 D Phage tail tape measure protein, TP901 family
COHBPNKO_01613 1.4e-10
COHBPNKO_01615 2.8e-53 S DNA primase
COHBPNKO_01616 3.2e-67 L Primase C terminal 2 (PriCT-2)
COHBPNKO_01620 3.4e-12
COHBPNKO_01621 3.4e-13 xre K sequence-specific DNA binding
COHBPNKO_01622 2.7e-133 L Belongs to the 'phage' integrase family
COHBPNKO_01625 1.7e-16
COHBPNKO_01626 1.1e-18 M MucBP domain
COHBPNKO_01627 9.1e-154 M MucBP domain
COHBPNKO_01628 2.5e-88
COHBPNKO_01629 9.2e-92 apt 2.4.2.7 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
COHBPNKO_01630 0.0 recJ L Single-stranded-DNA-specific exonuclease RecJ
COHBPNKO_01631 6.5e-156 XK27_05435 1.1.1.100 S Belongs to the short-chain dehydrogenases reductases (SDR) family
COHBPNKO_01632 1.3e-176 rnz 3.1.26.11 J Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
COHBPNKO_01633 8.8e-248 obg S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
COHBPNKO_01634 0.0 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
COHBPNKO_01635 4.9e-08
COHBPNKO_01636 6.1e-60 MA20_27270 S mazG nucleotide pyrophosphohydrolase
COHBPNKO_01637 1.4e-107 engB D Necessary for normal cell division and for the maintenance of normal septation
COHBPNKO_01638 6.2e-235 clpX O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
COHBPNKO_01639 2.8e-238 tig D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
COHBPNKO_01640 3.8e-226 tuf J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
COHBPNKO_01641 3.2e-164 S Tetratricopeptide repeat
COHBPNKO_01642 0.0 rnjB J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
COHBPNKO_01643 1.6e-42 rpsO J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
COHBPNKO_01644 5.1e-35 rpsT J Binds directly to 16S ribosomal RNA
COHBPNKO_01645 7e-223 L Transposase
COHBPNKO_01648 1.1e-250 L PFAM transposase, IS4 family protein
COHBPNKO_01649 2.1e-16
COHBPNKO_01650 6e-85 C Flavodoxin
COHBPNKO_01651 2.1e-165 S Oxidoreductase, aldo keto reductase family protein
COHBPNKO_01652 7.4e-178 1.1.1.1 C nadph quinone reductase
COHBPNKO_01653 5.6e-55 yphJ 4.1.1.44 S decarboxylase
COHBPNKO_01654 2e-96 M Protein of unknown function (DUF3737)
COHBPNKO_01655 2.2e-218 4.4.1.8 E Aminotransferase, class I
COHBPNKO_01656 8.1e-11 1.1.1.100 S Enoyl-(Acyl carrier protein) reductase
COHBPNKO_01657 7.4e-114 P nitric oxide dioxygenase activity
COHBPNKO_01658 1.8e-105 S Peptidase propeptide and YPEB domain
COHBPNKO_01659 3.6e-233 T GHKL domain
COHBPNKO_01660 3.4e-118 T Transcriptional regulatory protein, C terminal
COHBPNKO_01661 3.2e-66 mleP3 S Membrane transport protein
COHBPNKO_01662 2.3e-44 1.1.1.193, 3.5.4.26 H RibD C-terminal domain
COHBPNKO_01663 1.3e-35 1.1.1.193, 3.5.4.26 H RibD C-terminal domain
COHBPNKO_01667 4.1e-202 2.7.13.3 T GHKL domain
COHBPNKO_01668 7.7e-119 K LytTr DNA-binding domain
COHBPNKO_01670 1.1e-89 XK27_08850 J Aminoacyl-tRNA editing domain
COHBPNKO_01671 8.8e-56 yphI 1.14.99.57 S Antibiotic biosynthesis monooxygenase
COHBPNKO_01672 1.1e-194 V Beta-lactamase
COHBPNKO_01673 9.2e-95 hpt 2.4.2.8 F Belongs to the purine pyrimidine phosphoribosyltransferase family
COHBPNKO_01674 1.2e-123 yhiD S MgtC family
COHBPNKO_01675 1.3e-116 S GyrI-like small molecule binding domain
COHBPNKO_01676 5.2e-125 ybhF_2 V AAA domain, putative AbiEii toxin, Type IV TA system
COHBPNKO_01677 1e-183 ybhR V ABC transporter
COHBPNKO_01678 2.1e-90 K Bacterial regulatory proteins, tetR family
COHBPNKO_01679 2.2e-27
COHBPNKO_01680 1.1e-32
COHBPNKO_01681 7.5e-115 S Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)
COHBPNKO_01682 3.2e-50 azlD E Branched-chain amino acid transport
COHBPNKO_01683 5.7e-121 azlC E azaleucine resistance protein AzlC
COHBPNKO_01684 1.9e-261 K Aminotransferase class I and II
COHBPNKO_01685 1.9e-297 S amidohydrolase
COHBPNKO_01686 2.3e-92 S Alpha/beta hydrolase of unknown function (DUF915)
COHBPNKO_01687 7.4e-143 pts13C G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
COHBPNKO_01689 1.3e-159 S reductase
COHBPNKO_01690 4.4e-91 2.3.1.183 M Acetyltransferase GNAT family
COHBPNKO_01691 1.7e-113 lepB 3.4.21.89 U Belongs to the peptidase S26 family
COHBPNKO_01692 2.2e-248 yxbA 6.3.1.12 S ATP-grasp enzyme
COHBPNKO_01693 2e-291 murE 6.3.2.13, 6.3.2.7 M Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
COHBPNKO_01694 0.0 asnB 6.3.5.4 E Asparagine synthase
COHBPNKO_01695 0.0 gidA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
COHBPNKO_01696 2.8e-252 mnmE S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
COHBPNKO_01697 5.9e-135 jag S R3H domain protein
COHBPNKO_01698 1e-129 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
COHBPNKO_01699 2e-58 rnpA 3.1.26.5 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
COHBPNKO_01700 3.4e-14 rpmH J Belongs to the bacterial ribosomal protein bL34 family
COHBPNKO_01701 2.9e-251 dnaA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
COHBPNKO_01702 1.1e-206 dnaN 2.7.7.7 L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
COHBPNKO_01703 1.7e-34 yaaA S S4 domain protein YaaA
COHBPNKO_01704 4.2e-206 recF L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
COHBPNKO_01705 0.0 gyrB 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
COHBPNKO_01706 0.0 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
COHBPNKO_01707 1.2e-48 rpsF J Binds together with S18 to 16S ribosomal RNA
COHBPNKO_01708 2.2e-78 ssb L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
COHBPNKO_01709 1.6e-35 rpsR J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
COHBPNKO_01710 1.6e-174 L Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
COHBPNKO_01711 1.1e-250 L PFAM transposase, IS4 family protein
COHBPNKO_01712 3e-140 L Belongs to the 'phage' integrase family
COHBPNKO_01713 8e-10
COHBPNKO_01717 2.7e-17
COHBPNKO_01718 5e-46 ligA 2.7.7.7, 6.5.1.2 L BRCA1 C Terminus (BRCT) domain
COHBPNKO_01719 5.3e-84 3.4.21.88 K Peptidase S24-like
COHBPNKO_01725 6.3e-19
COHBPNKO_01728 5.5e-116 L DnaD domain protein
COHBPNKO_01730 4.5e-68
COHBPNKO_01732 4.8e-126
COHBPNKO_01737 8.8e-14
COHBPNKO_01738 2.3e-16
COHBPNKO_01742 4.2e-83 arpU S Phage transcriptional regulator, ArpU family
COHBPNKO_01744 1.2e-08
COHBPNKO_01745 1.2e-56 L HNH nucleases
COHBPNKO_01746 2.9e-65 L Phage terminase, small subunit
COHBPNKO_01747 3.9e-305 S overlaps another CDS with the same product name
COHBPNKO_01748 4e-175 S Phage portal protein
COHBPNKO_01749 4.6e-81 clpP 3.4.21.92 OU Belongs to the peptidase S14 family
COHBPNKO_01750 5.9e-171 S Phage capsid family
COHBPNKO_01751 1.3e-25 S Phage gp6-like head-tail connector protein
COHBPNKO_01752 3e-25 S Phage head-tail joining protein
COHBPNKO_01753 1.3e-38 S Bacteriophage HK97-gp10, putative tail-component
COHBPNKO_01754 1e-34 S Protein of unknown function (DUF806)
COHBPNKO_01755 5.8e-116 S Phage tail tube protein
COHBPNKO_01756 1.6e-11 S Phage tail assembly chaperone proteins, TAC
COHBPNKO_01757 3e-145 M by MetaGeneAnnotator
COHBPNKO_01758 3.4e-78 S Phage tail protein
COHBPNKO_01759 2e-145 ydhO 3.4.14.13 M Prophage endopeptidase tail
COHBPNKO_01760 1.4e-40 GT2,GT4 LM gp58-like protein
COHBPNKO_01767 4.8e-33 S Bacteriophage holin of superfamily 6 (Holin_LLH)
COHBPNKO_01768 1.6e-149 lysA2 M Glycosyl hydrolases family 25
COHBPNKO_01769 3.3e-35 S Phage derived protein Gp49-like (DUF891)
COHBPNKO_01770 8.5e-20 K Helix-turn-helix XRE-family like proteins
COHBPNKO_01771 3.7e-162 I alpha/beta hydrolase fold
COHBPNKO_01772 4.8e-94 frnE Q DSBA-like thioredoxin domain
COHBPNKO_01773 1.1e-54
COHBPNKO_01776 1.1e-250 L PFAM transposase, IS4 family protein
COHBPNKO_01777 1.6e-54 K helix_turn_helix, mercury resistance
COHBPNKO_01778 9.1e-167 cysK 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
COHBPNKO_01779 2.2e-159 metAA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to
COHBPNKO_01780 0.0 ysaB V FtsX-like permease family
COHBPNKO_01781 2.6e-135 macB2 V ABC transporter, ATP-binding protein
COHBPNKO_01782 7.4e-183 T PhoQ Sensor
COHBPNKO_01783 1.9e-124 K response regulator
COHBPNKO_01784 3.9e-156 ytbE 1.1.1.346 S Aldo keto reductase
COHBPNKO_01785 1.2e-135 pnuC H nicotinamide mononucleotide transporter
COHBPNKO_01786 7.5e-83 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
COHBPNKO_01787 1.5e-203
COHBPNKO_01788 5.9e-52
COHBPNKO_01789 9.1e-36
COHBPNKO_01790 1.2e-91 yxkA S Phosphatidylethanolamine-binding protein
COHBPNKO_01791 6.8e-147 ptp3 3.1.3.48 T Tyrosine phosphatase family
COHBPNKO_01792 8.1e-182 celE 3.2.1.4 GH5,GH9 E GDSL-like Lipase/Acylhydrolase family
COHBPNKO_01793 1.9e-225 galK 2.7.1.6 F Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
COHBPNKO_01794 3.4e-285 galT 2.7.7.12 G UDP-glucose--hexose-1-phosphate uridylyltransferase
COHBPNKO_01795 1.2e-180 galR K Transcriptional regulator
COHBPNKO_01796 9.5e-96 dedA 3.1.3.1 S SNARE associated Golgi protein
COHBPNKO_01797 2.3e-232 gltP U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
COHBPNKO_01798 5.6e-80 K AsnC family
COHBPNKO_01799 3.3e-80 uspA T universal stress protein
COHBPNKO_01800 0.0 lacS G Transporter
COHBPNKO_01801 1.6e-39
COHBPNKO_01802 1.4e-275 gnd 1.1.1.343, 1.1.1.44 H Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
COHBPNKO_01803 7.5e-288 zwf 1.1.1.363, 1.1.1.49 G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
COHBPNKO_01804 5.2e-193 yeaN P Transporter, major facilitator family protein
COHBPNKO_01805 9.3e-74 S 3-demethylubiquinone-9 3-methyltransferase
COHBPNKO_01806 2.2e-84 nrdI F Belongs to the NrdI family
COHBPNKO_01807 9.5e-242 yhdP S Transporter associated domain
COHBPNKO_01808 1.4e-156 ypdB V (ABC) transporter
COHBPNKO_01809 1.9e-89 GM epimerase
COHBPNKO_01810 1e-90 M1-874 K Domain of unknown function (DUF1836)
COHBPNKO_01811 2.3e-78 yybA 2.3.1.57 K Transcriptional regulator
COHBPNKO_01812 4.2e-135 XK27_07210 6.1.1.6 S B3 4 domain
COHBPNKO_01813 1.8e-172 S AI-2E family transporter
COHBPNKO_01814 2.3e-156 3.2.1.52 GH20 G Xylose isomerase domain protein TIM barrel
COHBPNKO_01815 2.9e-165
COHBPNKO_01816 3.5e-134 glpF U Belongs to the MIP aquaporin (TC 1.A.8) family
COHBPNKO_01817 4.3e-147 eutJ E Hsp70 protein
COHBPNKO_01818 4.7e-199 K helix_turn_helix, arabinose operon control protein
COHBPNKO_01819 6.2e-42 pduA_4 CQ BMC
COHBPNKO_01820 2.7e-134 pduB E BMC
COHBPNKO_01821 0.0 pduC 4.2.1.28 Q Dehydratase large subunit
COHBPNKO_01822 1.1e-127 pduD 4.2.1.28, 4.2.1.30 Q Dehydratase medium subunit
COHBPNKO_01823 3.7e-77 pduE 4.2.1.28 Q Dehydratase small subunit
COHBPNKO_01824 0.0 pduG D Diol dehydratase reactivase ATPase-like domain
COHBPNKO_01825 6.5e-60 pduH S Dehydratase medium subunit
COHBPNKO_01826 2.8e-73 pduK CQ BMC
COHBPNKO_01827 2.2e-42 pduA_4 CQ BMC
COHBPNKO_01828 4.2e-118 pduL 2.3.1.222, 2.3.1.8 Q Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate
COHBPNKO_01829 7.1e-89 S Putative propanediol utilisation
COHBPNKO_01830 8.9e-41 ccmL CQ Ethanolamine utilisation protein EutN/carboxysome
COHBPNKO_01831 2.8e-105 pduO 2.5.1.17 S Cobalamin adenosyltransferase
COHBPNKO_01832 7.4e-80 pduO S Haem-degrading
COHBPNKO_01833 9.9e-269 pduP 1.2.1.87 C Aldehyde dehydrogenase family
COHBPNKO_01834 4.8e-210 pduQ C Iron-containing alcohol dehydrogenase
COHBPNKO_01835 6.3e-221 ackA 2.7.2.1, 2.7.2.15 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
COHBPNKO_01836 5.5e-56 pduU E BMC
COHBPNKO_01837 1.4e-147 3.1.3.48 T Pfam:Y_phosphatase3C
COHBPNKO_01838 1.3e-119 pgm1 3.1.3.73 G phosphoglycerate mutase
COHBPNKO_01839 6.7e-80 P Cadmium resistance transporter
COHBPNKO_01840 5.7e-71 eutP E Ethanolamine utilisation - propanediol utilisation
COHBPNKO_01841 3.9e-78 fld C Flavodoxin
COHBPNKO_01842 6.6e-156 XK27_04590 S NADPH-dependent FMN reductase
COHBPNKO_01843 6.3e-102 cobO 2.5.1.17 S Cobalamin adenosyltransferase
COHBPNKO_01844 6.2e-207 cobD 4.1.1.81 E Aminotransferase class I and II
COHBPNKO_01845 1e-262 cbiA 6.3.5.11, 6.3.5.9 F Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source
COHBPNKO_01846 5.7e-180 cobD 6.3.1.10 H Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
COHBPNKO_01847 9.2e-124 cbiC 5.4.99.60, 5.4.99.61 H Precorrin-8X methylmutase
COHBPNKO_01848 3.5e-208 cbiD 2.1.1.195 H Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
COHBPNKO_01849 9.7e-109 cbiE 2.1.1.132, 2.1.1.289 H Tetrapyrrole (Corrin/Porphyrin) Methylases
COHBPNKO_01850 3.9e-96 cbiT 2.1.1.132, 2.1.1.196 H Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
COHBPNKO_01851 2.9e-134 cobM 1.3.1.76, 2.1.1.131, 2.1.1.133, 2.1.1.271, 3.7.1.12, 4.99.1.4 H Tetrapyrrole (Corrin/Porphyrin) Methylases
COHBPNKO_01852 5.5e-192 cbiG 2.1.1.131, 2.1.1.133, 2.1.1.271, 3.7.1.12 H Cobalamin synthesis G C-terminus
COHBPNKO_01853 2.8e-131 cobJ 2.1.1.131, 2.1.1.133, 2.1.1.271, 3.7.1.12, 6.3.5.10 H Tetrapyrrole (Corrin/Porphyrin) Methylases
COHBPNKO_01854 1.1e-133 cobK 1.3.1.106, 1.3.1.54, 2.1.1.195 H Precorrin-6x reductase CbiJ/CobK
COHBPNKO_01855 4e-259 cobA 2.1.1.107, 4.2.1.75 H Tetrapyrrole (Corrin/Porphyrin) Methylases
COHBPNKO_01856 2.6e-146 cbiK 4.99.1.3 H Cobalt chelatase (CbiK)
COHBPNKO_01857 1.9e-124 cobI 2.1.1.130, 2.1.1.151, 4.99.1.3 H Tetrapyrrole (Corrin/Porphyrin) Methylases
COHBPNKO_01858 2.4e-133 cbiM P Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
COHBPNKO_01859 1.9e-52 cbiN P Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
COHBPNKO_01860 1.7e-117 cbiQ P Cobalt transport protein
COHBPNKO_01861 1.7e-148 cbiO 2.1.1.195 P part of an ABC transporter complex. Responsible for energy coupling to the transport system
COHBPNKO_01862 4.8e-282 cobQ 6.3.5.10 H Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation
COHBPNKO_01863 7.9e-79 cysG 1.3.1.76, 4.99.1.4 H Putative NAD(P)-binding
COHBPNKO_01864 1.8e-229 hemA 1.2.1.70 H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
COHBPNKO_01865 8.5e-165 hemC 2.1.1.107, 2.5.1.61, 4.2.1.75 H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
COHBPNKO_01866 1.3e-179 hemB 4.2.1.24 H Delta-aminolevulinic acid dehydratase
COHBPNKO_01867 1.4e-250 hemL 5.4.3.8 H Aminotransferase class-III
COHBPNKO_01868 1.6e-103 cobU 2.7.1.156, 2.7.7.62, 6.3.5.10 H Cobinamide kinase / cobinamide phosphate guanyltransferase
COHBPNKO_01869 2.2e-134 cobS 2.7.8.26 H Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
COHBPNKO_01870 7e-112 gpm 3.1.3.73, 5.4.2.12 G Belongs to the phosphoglycerate mutase family
COHBPNKO_01871 5.3e-130 hemD 2.1.1.107, 4.2.1.75 H Uroporphyrinogen-III synthase
COHBPNKO_01872 2.2e-193 cobT 2.4.2.21, 6.3.5.11, 6.3.5.9 F Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)
COHBPNKO_01873 1.4e-60 S Domain of unknown function (DUF4430)
COHBPNKO_01874 1.2e-81 S ECF transporter, substrate-specific component
COHBPNKO_01875 3.7e-190 ldhA 1.1.1.28 C Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
COHBPNKO_01876 2.9e-307 lmrA V ABC transporter, ATP-binding protein
COHBPNKO_01877 0.0 yfiC V ABC transporter
COHBPNKO_01878 4.9e-284 pipD E Dipeptidase
COHBPNKO_01879 4.6e-88 ybaK J Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
COHBPNKO_01880 4e-133 gntR K UbiC transcription regulator-associated domain protein
COHBPNKO_01881 9.6e-126 I transferase activity, transferring acyl groups other than amino-acyl groups
COHBPNKO_01882 0.0 xfp 4.1.2.22, 4.1.2.9 G Phosphoketolase
COHBPNKO_01883 5.1e-243 yagE E amino acid
COHBPNKO_01884 2.6e-140 aroD S Serine hydrolase (FSH1)
COHBPNKO_01885 3.3e-242 brnQ U Component of the transport system for branched-chain amino acids
COHBPNKO_01886 5.2e-167 GK ROK family
COHBPNKO_01887 0.0 tetP J elongation factor G
COHBPNKO_01888 5.1e-81 uspA T universal stress protein
COHBPNKO_01889 8.7e-195 lplA 6.3.1.20 H Lipoate-protein ligase
COHBPNKO_01890 7.1e-63
COHBPNKO_01891 5.2e-14
COHBPNKO_01892 4.3e-108
COHBPNKO_01893 8e-136 V ABC transporter
COHBPNKO_01894 5.3e-212 EGP Major facilitator Superfamily
COHBPNKO_01895 1.9e-256 G PTS system Galactitol-specific IIC component
COHBPNKO_01896 4.1e-181 1.6.5.5 C Zinc-binding dehydrogenase
COHBPNKO_01897 9.1e-161
COHBPNKO_01898 1e-72 K Transcriptional regulator
COHBPNKO_01899 4e-189 D Alpha beta
COHBPNKO_01900 2.2e-52 ypaA S Protein of unknown function (DUF1304)
COHBPNKO_01901 0.0 yjcE P Sodium proton antiporter
COHBPNKO_01902 2.1e-52 yvlA
COHBPNKO_01903 7.5e-115 P Cobalt transport protein
COHBPNKO_01904 6.8e-251 cbiO1 S ABC transporter, ATP-binding protein
COHBPNKO_01905 1.9e-95 S ABC-type cobalt transport system, permease component
COHBPNKO_01906 3.3e-133 S membrane transporter protein
COHBPNKO_01907 2.1e-137 IQ KR domain
COHBPNKO_01908 9.5e-183 iunH2 3.2.2.1 F nucleoside hydrolase
COHBPNKO_01909 2e-180 yumC 1.18.1.2, 1.19.1.1, 1.8.1.9 C Ferredoxin--NADP reductase
COHBPNKO_01910 5.7e-24 S Domain of unknown function (DUF4767)
COHBPNKO_01911 1.5e-134 3.6.4.12 S PD-(D/E)XK nuclease family transposase
COHBPNKO_01912 6.4e-21 3.6.4.12 S PD-(D/E)XK nuclease family transposase
COHBPNKO_01914 1.5e-115 gph 3.1.3.18 S HAD hydrolase, family IA, variant
COHBPNKO_01915 2.3e-254 yagE E amino acid
COHBPNKO_01916 3.8e-84 dps P Belongs to the Dps family
COHBPNKO_01917 0.0 pacL 3.6.3.8 P P-type ATPase
COHBPNKO_01918 1.9e-177 pip 3.4.11.5 E Releases the N-terminal proline from various substrates
COHBPNKO_01919 0.0 pepX 3.4.14.11 E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline
COHBPNKO_01920 2e-205 potA 3.6.3.30, 3.6.3.31 P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
COHBPNKO_01921 4.5e-146 potB P ABC transporter permease
COHBPNKO_01922 4.9e-140 potC P ABC transporter permease
COHBPNKO_01923 4.3e-208 potD P ABC transporter
COHBPNKO_01924 3.3e-231
COHBPNKO_01925 4.2e-250 serS 6.1.1.11 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
COHBPNKO_01926 2.6e-264 glnP P ABC transporter
COHBPNKO_01927 1.4e-138 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
COHBPNKO_01928 6.5e-222 cycA E Amino acid permease
COHBPNKO_01929 1e-218 nupG F Nucleoside transporter
COHBPNKO_01930 2.7e-171 rihC 3.2.2.1 F Nucleoside
COHBPNKO_01931 7.7e-163 fadB4 1.1.1.157 I 3-hydroxyacyl-CoA dehydrogenase
COHBPNKO_01932 2.1e-126 rsmG 2.1.1.170 J Specifically methylates the N7 position of a guanine in 16S rRNA
COHBPNKO_01933 8.1e-150 noc K Belongs to the ParB family
COHBPNKO_01934 3.9e-139 soj D Sporulation initiation inhibitor
COHBPNKO_01935 6.5e-154 spo0J K Belongs to the ParB family
COHBPNKO_01936 5.4e-32 yyzM S Bacterial protein of unknown function (DUF951)
COHBPNKO_01937 2e-200 ychF J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
COHBPNKO_01938 4.5e-135 XK27_01040 S Protein of unknown function (DUF1129)
COHBPNKO_01939 3.4e-118 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
COHBPNKO_01940 1.1e-236 deoB 5.4.2.7 G Phosphotransfer between the C1 and C5 carbon atoms of pentose
COHBPNKO_01941 7.6e-236 pdp 2.4.2.2, 2.4.2.4 F pyrimidine-nucleoside phosphorylase
COHBPNKO_01942 1.1e-130 deoD 2.4.2.1, 2.4.2.28 F Purine nucleoside phosphorylase
COHBPNKO_01943 6.2e-171 deoR K sugar-binding domain protein
COHBPNKO_01944 4.1e-209 guaB 1.1.1.205 F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
COHBPNKO_01945 3.8e-125 K response regulator
COHBPNKO_01946 1.8e-201 hpk31 2.7.13.3 T Histidine kinase
COHBPNKO_01947 2.2e-141 azlC E AzlC protein
COHBPNKO_01948 2.4e-51 azlD S branched-chain amino acid
COHBPNKO_01949 1.1e-132 K LysR substrate binding domain
COHBPNKO_01950 3.3e-172 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
COHBPNKO_01951 5.6e-247 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
COHBPNKO_01952 8.6e-173 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
COHBPNKO_01953 4.6e-129 pyrF 4.1.1.23 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
COHBPNKO_01954 5.1e-116 pyrE 2.4.2.10, 4.1.1.23 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
COHBPNKO_01955 1.7e-111 thiE 2.5.1.3, 2.7.6.2, 5.4.2.6 S Haloacid dehalogenase-like hydrolase
COHBPNKO_01956 3.8e-98 ribA 3.5.4.25, 4.1.99.12 H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
COHBPNKO_01957 2.1e-235 cfa 2.1.1.317, 2.1.1.79 M cyclopropane-fatty-acyl-phospholipid synthase
COHBPNKO_01958 4.7e-172 K AI-2E family transporter
COHBPNKO_01959 0.0 fhs 6.3.4.3 F Belongs to the formate--tetrahydrofolate ligase family
COHBPNKO_01960 0.0 alsS 2.2.1.6 EH Belongs to the TPP enzyme family
COHBPNKO_01961 1.4e-130 budA 4.1.1.5 H Belongs to the alpha-acetolactate decarboxylase family
COHBPNKO_01962 1.1e-83 purE 5.4.99.18 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
COHBPNKO_01963 6.6e-215 purK 6.3.4.18 F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
COHBPNKO_01964 2.4e-253 purB 4.3.2.2 F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
COHBPNKO_01965 9.7e-132 purC 4.1.1.21, 4.3.2.2, 6.3.2.6 F Belongs to the SAICAR synthetase family
COHBPNKO_01966 1.3e-38 purS 6.3.2.6, 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
COHBPNKO_01967 2.3e-127 purQ 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
COHBPNKO_01968 0.0 purL 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
COHBPNKO_01969 3.2e-275 purF 2.4.2.14 F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
COHBPNKO_01970 3.1e-195 purM 6.3.3.1, 6.3.4.13 F Phosphoribosylformylglycinamidine cyclo-ligase
COHBPNKO_01971 4e-104 purN 2.1.2.2 F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
COHBPNKO_01972 8e-293 purH 2.1.2.3, 3.5.4.10 F Bifunctional purine biosynthesis protein PurH
COHBPNKO_01973 1.5e-244 purD 6.3.4.13 F Belongs to the GARS family
COHBPNKO_01974 1e-130 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
COHBPNKO_01975 5.7e-165
COHBPNKO_01976 1.3e-240 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
COHBPNKO_01978 5.8e-283 GT2,GT4 M family 8
COHBPNKO_01979 0.0 M family 8
COHBPNKO_01981 5e-259 gtf2 M A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1
COHBPNKO_01982 3.4e-291 gtf1 2.4.1.52 GT4 M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
COHBPNKO_01983 0.0 secA2 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
COHBPNKO_01984 5.7e-166 asp3 S Accessory Sec secretory system ASP3
COHBPNKO_01985 9.2e-294 asp2 3.4.11.5 S Accessory Sec system GspB-transporter
COHBPNKO_01986 8.2e-298 M transferase activity, transferring glycosyl groups
COHBPNKO_01987 4.3e-209 secY2 U Part of the accessory SecA2 SecY2 system specifically required for export of
COHBPNKO_01988 2.9e-190 nss M transferase activity, transferring glycosyl groups
COHBPNKO_01989 1.6e-155 L Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
COHBPNKO_01990 0.0 M LPXTG-motif cell wall anchor domain protein
COHBPNKO_01991 0.0 trxB2 1.8.1.9 C Thioredoxin domain
COHBPNKO_01992 1.2e-105 ahpC 1.11.1.15 O Peroxiredoxin
COHBPNKO_01993 3.8e-138 sdaAA 4.3.1.17 E L-serine dehydratase, iron-sulfur-dependent, alpha subunit
COHBPNKO_01994 1.9e-118 sdaAB 4.3.1.17 E Serine dehydratase beta chain
COHBPNKO_01996 7e-43 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
COHBPNKO_01997 8.4e-167 T Calcineurin-like phosphoesterase superfamily domain
COHBPNKO_01998 8.2e-224 mdtG EGP Major facilitator Superfamily
COHBPNKO_01999 6.8e-130 menG 2.1.1.163, 2.1.1.201 H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)
COHBPNKO_02000 8.5e-223 yxjG_1 E methionine synthase, vitamin-B12 independent
COHBPNKO_02001 6.7e-144 XK27_00940 1.2.1.70, 3.5.1.9 S Putative cyclase
COHBPNKO_02002 8.9e-159 menA 2.5.1.74 H 1,4-dihydroxy-2-naphthoate
COHBPNKO_02003 3.2e-178 hepT 2.5.1.30, 2.5.1.90 H Belongs to the FPP GGPP synthase family
COHBPNKO_02004 6.9e-225 brpA K Cell envelope-like function transcriptional attenuator common domain protein
COHBPNKO_02005 1.7e-309 prfC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
COHBPNKO_02006 0.0 M NlpC/P60 family
COHBPNKO_02007 2.5e-14 S Domain of unknown function (DUF4767)
COHBPNKO_02008 3.5e-10 S DNA repair protein MmcB-like
COHBPNKO_02012 7.5e-90 L Integrase
COHBPNKO_02013 1.7e-14 K Transcriptional
COHBPNKO_02014 2.8e-92 L Uncharacterized conserved protein (DUF2075)
COHBPNKO_02017 3.6e-100 S NgoFVII restriction endonuclease
COHBPNKO_02018 6e-158 dcm 2.1.1.37 H cytosine-specific methyltransferase
COHBPNKO_02019 1.3e-49 vsr L DNA mismatch endonuclease Vsr
COHBPNKO_02023 2.4e-10
COHBPNKO_02024 2.8e-82 L Phage integrase, N-terminal SAM-like domain
COHBPNKO_02025 5.9e-36 L Single-strand binding protein family
COHBPNKO_02026 2.3e-102 L Replication initiation factor
COHBPNKO_02027 4e-19 S Lysin motif
COHBPNKO_02028 5.6e-56 L Lactococcus lactis RepB C-terminus
COHBPNKO_02029 2.1e-151 ltrA_1 2.7.7.49 L PFAM RNA-directed DNA polymerase (Reverse transcriptase)
COHBPNKO_02030 6e-200 L Transposase
COHBPNKO_02031 5.7e-106 wecD3 K PFAM GCN5-related N-acetyltransferase
COHBPNKO_02032 1.9e-283 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
COHBPNKO_02033 0.0 rexB 3.1.21.3, 3.6.4.12 L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' - 3' nuclease activity
COHBPNKO_02034 0.0 addA 3.6.4.12 L ATP-dependent helicase nuclease subunit A
COHBPNKO_02035 3.9e-173 malR K Transcriptional regulator, LacI family
COHBPNKO_02036 1.2e-211 phbA 2.3.1.9 I Belongs to the thiolase family
COHBPNKO_02037 1.1e-256 malT G Major Facilitator
COHBPNKO_02038 0.0 mapA 2.4.1.8 GH65 G hydrolase, family 65, central catalytic
COHBPNKO_02039 2.1e-120 pgmB 2.4.1.64, 3.1.3.12, 3.2.1.28, 5.4.2.6 GH37,GH65 S beta-phosphoglucomutase
COHBPNKO_02040 1.1e-86 2.7.6.5 T Region found in RelA / SpoT proteins
COHBPNKO_02041 1.1e-113 K response regulator
COHBPNKO_02042 8.7e-221 sptS 2.7.13.3 T Histidine kinase
COHBPNKO_02043 1.5e-206 yfeO P Voltage gated chloride channel
COHBPNKO_02044 3.3e-258 gshF 6.3.2.2 H Belongs to the glutamate--cysteine ligase type 1 family
COHBPNKO_02045 7.8e-137 puuD S peptidase C26
COHBPNKO_02046 2.3e-167 yvgN C Aldo keto reductase
COHBPNKO_02047 0.0 glpQ 3.1.4.46 C Membrane domain of glycerophosphoryl diester phosphodiesterase
COHBPNKO_02048 2.3e-87 hmpT S ECF-type riboflavin transporter, S component
COHBPNKO_02049 2.4e-261 nox C NADH oxidase
COHBPNKO_02050 4.2e-186 guaC 1.1.1.205, 1.7.1.7 F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
COHBPNKO_02051 2.4e-253 purA 6.3.4.4 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
COHBPNKO_02052 3.9e-86
COHBPNKO_02053 4.1e-95 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
COHBPNKO_02055 9.9e-112 K Transcriptional regulator, TetR family
COHBPNKO_02056 1e-69
COHBPNKO_02057 4e-268 tagE3 2.4.1.52 GT4 M Glycosyl transferases group 1
COHBPNKO_02058 2.3e-268 tagE2 2.4.1.52 GT4 M Poly(Glycerol-phosphate) alpha-glucosyltransferase
COHBPNKO_02059 1.4e-288 M domain protein
COHBPNKO_02060 0.0 malL 3.2.1.10 GH13 G Alpha amylase, catalytic domain protein
COHBPNKO_02061 2e-266 G Major Facilitator
COHBPNKO_02062 0.0 carB 6.3.5.5 F Carbamoyl-phosphate synthase
COHBPNKO_02063 1.9e-203 carA 6.3.5.5 F Carbamoyl-phosphate synthetase glutamine chain
COHBPNKO_02064 6.1e-260 G Major Facilitator
COHBPNKO_02065 1e-179 K Transcriptional regulator, LacI family
COHBPNKO_02066 4.5e-266 rumA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
COHBPNKO_02067 6.4e-102 nqr 1.5.1.36 S reductase
COHBPNKO_02068 7.9e-198 XK27_09615 S reductase
COHBPNKO_02069 4.7e-179 apbE 2.7.1.180 H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein

eggNOG-mapper v2 (Database: eggNOG v5.0, Jul. 2018 release)