ORF_ID e_value Gene_name EC_number CAZy COGs Description
HGMPKFMI_00001 3.2e-25 pckA 4.1.1.49 H Phosphoenolpyruvate carboxykinase
HGMPKFMI_00002 6.6e-281 pckA 4.1.1.49 H Phosphoenolpyruvate carboxykinase
HGMPKFMI_00003 8.4e-265 frdC 1.3.5.4 C FAD binding domain
HGMPKFMI_00004 3.4e-113 metI P ABC transporter permease
HGMPKFMI_00005 5.3e-187 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HGMPKFMI_00006 3.2e-121 metQ2 P Belongs to the nlpA lipoprotein family
HGMPKFMI_00007 0.0 aha1 P E1-E2 ATPase
HGMPKFMI_00008 1.1e-89 folA 1.5.1.3 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HGMPKFMI_00009 1.8e-189 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HGMPKFMI_00010 2.9e-122 1.1.1.28 CH D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
HGMPKFMI_00011 1.2e-64
HGMPKFMI_00012 0.0 E ABC transporter, substratebinding protein
HGMPKFMI_00014 1.1e-124 pnb C nitroreductase
HGMPKFMI_00016 6.1e-259 I Protein of unknown function (DUF2974)
HGMPKFMI_00017 6.3e-108 engB D Necessary for normal cell division and for the maintenance of normal septation
HGMPKFMI_00018 1.4e-231 clpX O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HGMPKFMI_00019 2.1e-212 tig D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
HGMPKFMI_00020 2.8e-224 tuf J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HGMPKFMI_00021 4.5e-149
HGMPKFMI_00022 0.0 rnjB J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HGMPKFMI_00023 6e-42 rpsO J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HGMPKFMI_00024 1.6e-33 rpsT J Binds directly to 16S ribosomal RNA
HGMPKFMI_00025 1e-179 holA 2.7.7.7 L DNA polymerase III delta subunit
HGMPKFMI_00026 0.0 comEC S Competence protein ComEC
HGMPKFMI_00027 1.1e-69 comEA L Competence protein ComEA
HGMPKFMI_00028 7.8e-191 ylbL T Belongs to the peptidase S16 family
HGMPKFMI_00029 7.5e-83 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HGMPKFMI_00030 1.6e-97 rsmD 2.1.1.171 L RNA methyltransferase, RsmD family
HGMPKFMI_00031 1.1e-53 ylbG S UPF0298 protein
HGMPKFMI_00032 2.2e-213 ftsW D Belongs to the SEDS family
HGMPKFMI_00033 0.0 typA T GTP-binding protein TypA
HGMPKFMI_00034 4.7e-102 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
HGMPKFMI_00035 2.7e-35 ykzG S Belongs to the UPF0356 family
HGMPKFMI_00036 0.0 rnjA J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HGMPKFMI_00037 1.8e-251 merA 1.16.1.1, 1.8.1.7 C Pyridine nucleotide-disulfide oxidoreductase
HGMPKFMI_00038 0.0 recD2 3.1.11.5 L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
HGMPKFMI_00039 1e-103 S Repeat protein
HGMPKFMI_00040 2e-123 pgm6 5.4.2.11, 5.4.2.12 G Phosphoglycerate mutase family
HGMPKFMI_00041 3.5e-221 mnmA 2.8.1.13 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
HGMPKFMI_00042 3.2e-56 XK27_04120 S Putative amino acid metabolism
HGMPKFMI_00043 2.8e-213 iscS 2.8.1.7 E Aminotransferase class V
HGMPKFMI_00044 3.1e-127 mtnN 3.2.2.9 E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HGMPKFMI_00045 5.4e-19
HGMPKFMI_00046 2.8e-102 nudF 3.6.1.13 L ADP-ribose pyrophosphatase
HGMPKFMI_00047 1.5e-32 cspA K 'Cold-shock' DNA-binding domain
HGMPKFMI_00048 0.0 ileS 6.1.1.5 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HGMPKFMI_00049 9.1e-147 ylmH S S4 domain protein
HGMPKFMI_00050 7.6e-46 yggT S YGGT family
HGMPKFMI_00051 1.1e-64 sepF D Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
HGMPKFMI_00052 3.6e-204 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HGMPKFMI_00053 2.2e-241 ftsA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
HGMPKFMI_00054 2.3e-148 divIB D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
HGMPKFMI_00055 1.2e-208 murG 2.4.1.227, 6.3.2.8 GT28 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HGMPKFMI_00056 5.6e-261 murD 6.3.2.9 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HGMPKFMI_00057 2.7e-177 mraY 2.7.8.13 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HGMPKFMI_00058 0.0 ftsI 3.4.16.4 M Penicillin-binding Protein
HGMPKFMI_00059 4.8e-55 ftsL D Cell division protein FtsL
HGMPKFMI_00060 1.1e-172 rsmH 2.1.1.199 J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
HGMPKFMI_00061 1.6e-76 mraZ K Belongs to the MraZ family
HGMPKFMI_00062 5.7e-55 S Protein of unknown function (DUF3397)
HGMPKFMI_00064 1.1e-95 mreD
HGMPKFMI_00065 8.2e-138 mreC M Involved in formation and maintenance of cell shape
HGMPKFMI_00066 2.6e-175 mreB D cell shape determining protein MreB
HGMPKFMI_00067 1.2e-114 radC L DNA repair protein
HGMPKFMI_00068 6.8e-127 S Haloacid dehalogenase-like hydrolase
HGMPKFMI_00069 2.6e-233 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
HGMPKFMI_00070 0.0 valS 6.1.1.9 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
HGMPKFMI_00071 7.8e-129 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
HGMPKFMI_00072 4.6e-227 thiI 2.8.1.4 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HGMPKFMI_00073 1.1e-217 iscS2 2.8.1.7 E Aminotransferase class V
HGMPKFMI_00074 4.9e-299 ezrA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HGMPKFMI_00075 1.2e-109 rpsD J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HGMPKFMI_00076 1e-81 yueI S Protein of unknown function (DUF1694)
HGMPKFMI_00077 1.6e-241 rarA L recombination factor protein RarA
HGMPKFMI_00078 1.3e-42
HGMPKFMI_00079 3e-78 usp6 T universal stress protein
HGMPKFMI_00080 2.7e-219 rodA D Belongs to the SEDS family
HGMPKFMI_00081 1.7e-34 S Protein of unknown function (DUF2969)
HGMPKFMI_00082 7.4e-48 yidD S Could be involved in insertion of integral membrane proteins into the membrane
HGMPKFMI_00083 6.1e-177 mbl D Cell shape determining protein MreB Mrl
HGMPKFMI_00084 3.9e-32 ywzB S Protein of unknown function (DUF1146)
HGMPKFMI_00085 4.8e-73 atpC C Produces ATP from ADP in the presence of a proton gradient across the membrane
HGMPKFMI_00086 1.9e-248 atpD 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HGMPKFMI_00087 2.4e-170 atpG C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HGMPKFMI_00088 6.5e-279 atpA 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HGMPKFMI_00089 1.8e-93 atpH C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HGMPKFMI_00090 4.2e-57 atpF C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HGMPKFMI_00091 3.1e-28 atpE C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HGMPKFMI_00092 4.2e-127 atpB C it plays a direct role in the translocation of protons across the membrane
HGMPKFMI_00093 6.8e-113 upp 2.4.2.9 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HGMPKFMI_00094 9.1e-189 ywlC 2.7.7.87, 3.1.3.48 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
HGMPKFMI_00095 3e-156 prmB 2.1.1.297, 2.1.1.298 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
HGMPKFMI_00096 2.1e-194 prfA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HGMPKFMI_00097 1.4e-112 tdk 2.7.1.21 F thymidine kinase
HGMPKFMI_00098 3.2e-261 murD 3.4.21.10, 6.3.2.13, 6.3.2.9 M Mur ligase, middle domain
HGMPKFMI_00099 4.3e-34
HGMPKFMI_00100 7.6e-191 ampC V Beta-lactamase
HGMPKFMI_00103 3.2e-178 oppA E ABC transporter, substratebinding protein
HGMPKFMI_00104 1.4e-23 oppA E ABC transporter, substratebinding protein
HGMPKFMI_00105 6.2e-257 pgi 5.3.1.9 G Belongs to the GPI family
HGMPKFMI_00106 1.1e-107 vanZ V VanZ like family
HGMPKFMI_00107 0.0 ltaS 2.7.8.20 M Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
HGMPKFMI_00108 9.1e-276 T PhoQ Sensor
HGMPKFMI_00109 3e-133 K Transcriptional regulatory protein, C terminal
HGMPKFMI_00112 2.6e-222 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HGMPKFMI_00113 1e-184 ytxK 2.1.1.72 L N-6 DNA Methylase
HGMPKFMI_00114 2.5e-10 comGF U Putative Competence protein ComGF
HGMPKFMI_00116 3e-75
HGMPKFMI_00117 6.5e-51 comGC U competence protein ComGC
HGMPKFMI_00118 1.3e-158 comGB NU type II secretion system
HGMPKFMI_00119 4.4e-180 comGA NU Type II IV secretion system protein
HGMPKFMI_00120 1.4e-130 yebC K Transcriptional regulatory protein
HGMPKFMI_00121 7.7e-94 S VanZ like family
HGMPKFMI_00122 1.2e-163 psaA P Belongs to the bacterial solute-binding protein 9 family
HGMPKFMI_00123 8.9e-158 rssA S Phospholipase, patatin family
HGMPKFMI_00124 2.2e-101 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HGMPKFMI_00125 0.0 E Amino acid permease
HGMPKFMI_00126 1.7e-63 GM epimerase
HGMPKFMI_00127 6.3e-84 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HGMPKFMI_00128 3.1e-66
HGMPKFMI_00129 1.5e-25
HGMPKFMI_00130 1.7e-125 T Diguanylate cyclase, GGDEF domain
HGMPKFMI_00131 5.2e-119 T Diguanylate cyclase, GGDEF domain
HGMPKFMI_00132 1e-181 yliE T Putative diguanylate phosphodiesterase
HGMPKFMI_00133 4.3e-149 T diguanylate cyclase activity
HGMPKFMI_00134 4.4e-138
HGMPKFMI_00135 5e-60 crcB U Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HGMPKFMI_00136 2.5e-65 crcB U Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HGMPKFMI_00137 0.0 copA 3.6.3.54 P P-type ATPase
HGMPKFMI_00138 8.5e-55 silP 1.9.3.1, 3.6.3.54 S Cupredoxin-like domain
HGMPKFMI_00139 1.4e-77 atkY K Copper transport repressor CopY TcrY
HGMPKFMI_00140 1.1e-56 V peptidase activity
HGMPKFMI_00141 6.8e-150 S hydrolase
HGMPKFMI_00142 2e-255 glmM 5.4.2.10 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HGMPKFMI_00143 1.5e-164 ybbR S YbbR-like protein
HGMPKFMI_00144 4.1e-150 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HGMPKFMI_00145 5.3e-206 potD P ABC transporter
HGMPKFMI_00146 3.9e-129 potC P ABC transporter permease
HGMPKFMI_00147 1.1e-144 potB P ABC transporter permease
HGMPKFMI_00148 1.4e-203 potA 3.6.3.30, 3.6.3.31 P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
HGMPKFMI_00149 2.9e-162 murB 1.3.1.98 M Cell wall formation
HGMPKFMI_00150 1.2e-97 dnaQ 2.7.7.7 L DNA polymerase III
HGMPKFMI_00151 4.6e-85 ydiB 2.7.1.221, 5.1.1.1 O Hydrolase, P-loop family
HGMPKFMI_00152 9.7e-183 pta 2.3.1.8, 3.6.3.21 C phosphate acetyltransferase
HGMPKFMI_00153 2.3e-135 ung 3.2.2.27 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HGMPKFMI_00154 3.7e-157 ycsE S Sucrose-6F-phosphate phosphohydrolase
HGMPKFMI_00155 8e-105
HGMPKFMI_00156 5.1e-23 3.2.2.20 K acetyltransferase
HGMPKFMI_00157 5.7e-27 3.2.2.20 K acetyltransferase
HGMPKFMI_00158 8.4e-142 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
HGMPKFMI_00159 3e-226 pgk 2.7.2.3, 5.3.1.1 F Belongs to the phosphoglycerate kinase family
HGMPKFMI_00160 2.2e-190 gap 1.2.1.12 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
HGMPKFMI_00161 1.8e-212 cggR K Putative sugar-binding domain
HGMPKFMI_00163 1.9e-112 XK27_08845 S ABC transporter, ATP-binding protein
HGMPKFMI_00164 1.5e-49 XK27_08840 U Belongs to the binding-protein-dependent transport system permease family
HGMPKFMI_00165 3.4e-29 ABC-SBP S ABC transporter substrate binding protein
HGMPKFMI_00166 3.5e-285
HGMPKFMI_00167 5.5e-101 clpP 3.4.21.92 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
HGMPKFMI_00168 1.5e-169 whiA K May be required for sporulation
HGMPKFMI_00169 1.4e-189 ybhK S Required for morphogenesis under gluconeogenic growth conditions
HGMPKFMI_00170 2.4e-164 rapZ S Displays ATPase and GTPase activities
HGMPKFMI_00171 2.3e-84 dmpA 3.4.11.19 EQ Peptidase family S58
HGMPKFMI_00173 7.2e-124 E D-aminopeptidase
HGMPKFMI_00174 7.4e-92 S Short repeat of unknown function (DUF308)
HGMPKFMI_00175 0.0 uvrA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
HGMPKFMI_00176 0.0 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
HGMPKFMI_00177 8.3e-176 trxB 1.8.1.9 C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
HGMPKFMI_00178 5e-190 gpsA 1.1.1.94 I Glycerol-3-phosphate dehydrogenase
HGMPKFMI_00179 1.5e-155 lgt 2.1.1.199 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HGMPKFMI_00180 1.2e-174 hprK F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HGMPKFMI_00181 9.1e-31
HGMPKFMI_00182 5.9e-188 prfB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HGMPKFMI_00183 0.0 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
HGMPKFMI_00184 1.6e-97 hpf J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HGMPKFMI_00185 2.3e-122 comFC S Competence protein
HGMPKFMI_00186 2.7e-246 comFA L Helicase C-terminal domain protein
HGMPKFMI_00187 4.7e-117 yvyE 3.4.13.9 S YigZ family
HGMPKFMI_00188 1.1e-212 tagO 2.7.8.33, 2.7.8.35 M transferase
HGMPKFMI_00189 5.1e-221 rny S Endoribonuclease that initiates mRNA decay
HGMPKFMI_00190 4.6e-197 recA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HGMPKFMI_00191 2.7e-97 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HGMPKFMI_00192 1.7e-106 ymfM S Helix-turn-helix domain
HGMPKFMI_00193 5.2e-133 IQ Enoyl-(Acyl carrier protein) reductase
HGMPKFMI_00194 1.8e-237 S Peptidase M16
HGMPKFMI_00195 4.5e-230 2.7.1.26, 2.7.7.2 S Peptidase M16 inactive domain protein
HGMPKFMI_00196 0.0 ftsK D Belongs to the FtsK SpoIIIE SftA family
HGMPKFMI_00197 1.9e-68 WQ51_03320 S Protein of unknown function (DUF1149)
HGMPKFMI_00198 8.7e-104 trmL 2.1.1.207 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
HGMPKFMI_00199 2.1e-181 yubA S AI-2E family transporter
HGMPKFMI_00200 4.6e-64 srlB 2.7.1.198 G PTS system glucitol/sorbitol-specific IIA component
HGMPKFMI_00201 2.9e-198 pgl 3.1.1.31 G Lactonase, 7-bladed beta-propeller
HGMPKFMI_00202 1.1e-147 uppP 3.6.1.27 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
HGMPKFMI_00203 2.8e-22
HGMPKFMI_00204 8.2e-173 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
HGMPKFMI_00205 3.9e-150 nadK 2.7.1.23 F Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HGMPKFMI_00206 3.1e-113 yjbM 2.7.6.5 S RelA SpoT domain protein
HGMPKFMI_00207 3.3e-109 yjbK S CYTH
HGMPKFMI_00208 5.9e-112 yjbH Q Thioredoxin
HGMPKFMI_00209 4.4e-163 coiA 3.6.4.12 S Competence protein
HGMPKFMI_00210 5.2e-136 mecA NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
HGMPKFMI_00211 5e-69 spxA 1.20.4.1 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
HGMPKFMI_00212 2.1e-302 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HGMPKFMI_00213 1.2e-39 ptsH G phosphocarrier protein HPR
HGMPKFMI_00214 5.8e-10
HGMPKFMI_00215 0.0 clpE O Belongs to the ClpA ClpB family
HGMPKFMI_00216 1.1e-43 XK27_09445 S Domain of unknown function (DUF1827)
HGMPKFMI_00217 4.3e-73 mco Q Multicopper oxidase
HGMPKFMI_00218 7.3e-209 mco Q Multicopper oxidase
HGMPKFMI_00219 5.4e-19
HGMPKFMI_00220 1.6e-304 prfC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HGMPKFMI_00221 1.2e-157 hlyX S Transporter associated domain
HGMPKFMI_00222 3.5e-74
HGMPKFMI_00223 4.5e-85
HGMPKFMI_00224 1.7e-145 recX 2.4.1.337 GT4 S Regulatory protein RecX
HGMPKFMI_00225 1.8e-243 rumA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HGMPKFMI_00226 1.1e-181 D Alpha beta
HGMPKFMI_00227 7.4e-19
HGMPKFMI_00228 4.6e-171 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
HGMPKFMI_00229 7.7e-166 yihY S Belongs to the UPF0761 family
HGMPKFMI_00230 3.6e-162 map 3.4.11.18 E Methionine Aminopeptidase
HGMPKFMI_00231 1.3e-78 fld C Flavodoxin
HGMPKFMI_00232 3.3e-51 gtcA S Teichoic acid glycosylation protein
HGMPKFMI_00233 5e-215 mnaA 5.1.3.14 G Belongs to the UDP-N-acetylglucosamine 2-epimerase family
HGMPKFMI_00234 2.3e-31
HGMPKFMI_00235 8.7e-181 E Amino acid permease
HGMPKFMI_00237 0.0 yaaO 4.1.1.17, 4.1.1.19 E Orn/Lys/Arg decarboxylase, C-terminal domain
HGMPKFMI_00238 1.1e-228 ynbB 4.4.1.1 P aluminum resistance
HGMPKFMI_00239 1e-232 pyrP F Permease
HGMPKFMI_00240 4.2e-139 pfoS S Phosphotransferase system, EIIC
HGMPKFMI_00241 1.9e-31 pfoS S Phosphotransferase system, EIIC
HGMPKFMI_00243 9.8e-247 celB G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HGMPKFMI_00244 2.9e-208 yfmL 3.6.4.13 L DEAD DEAH box helicase
HGMPKFMI_00245 1e-122 lytC 3.2.1.17, 3.2.1.96 M Glycosyl hydrolases family 25
HGMPKFMI_00246 6.4e-227 potE E amino acid
HGMPKFMI_00247 4.9e-102 hpt 2.4.2.8 F Belongs to the purine pyrimidine phosphoribosyltransferase family
HGMPKFMI_00248 2.1e-249 yhdP S Transporter associated domain
HGMPKFMI_00249 2.9e-21 3.4.22.70 M Sortase family
HGMPKFMI_00251 0.0 xfp 4.1.2.22, 4.1.2.9 G Phosphoketolase
HGMPKFMI_00252 2.4e-130 gntR K UbiC transcription regulator-associated domain protein
HGMPKFMI_00253 7.8e-174 rihB 3.2.2.1 F Nucleoside
HGMPKFMI_00254 6.7e-122 rpiA 2.7.1.12, 2.7.1.15, 5.3.1.6 G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HGMPKFMI_00255 2e-120 rpe 5.1.3.1 G Belongs to the ribulose-phosphate 3-epimerase family
HGMPKFMI_00256 3.3e-161 rbsK 2.7.1.15 H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HGMPKFMI_00257 5.9e-88
HGMPKFMI_00258 9e-37
HGMPKFMI_00259 5.6e-10 S Protein of unknown function (DUF2974)
HGMPKFMI_00260 3.3e-269 S Uncharacterized protein conserved in bacteria (DUF2252)
HGMPKFMI_00261 0.0 ppk 2.7.4.1 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HGMPKFMI_00262 9.7e-283 ppx3 3.6.1.11, 3.6.1.40 FP exopolyphosphatase
HGMPKFMI_00263 2.9e-148 glnH ET Bacterial periplasmic substrate-binding proteins
HGMPKFMI_00264 5.7e-110 glnP P ABC transporter permease
HGMPKFMI_00265 2.5e-110 gluC P ABC transporter permease
HGMPKFMI_00266 5.4e-150 glnH ET ABC transporter substrate-binding protein
HGMPKFMI_00267 2.8e-134 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
HGMPKFMI_00268 3.3e-118 udk 2.7.1.48 F Zeta toxin
HGMPKFMI_00269 3.7e-111 udk 2.7.1.48 F Zeta toxin
HGMPKFMI_00271 7.8e-100 S ABC-type cobalt transport system, permease component
HGMPKFMI_00272 7.8e-210 pepA E M42 glutamyl aminopeptidase
HGMPKFMI_00273 2.2e-281 pipD E Dipeptidase
HGMPKFMI_00274 1.7e-142 murI 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
HGMPKFMI_00275 5.5e-119 ybhL S Belongs to the BI1 family
HGMPKFMI_00276 3.3e-217 mdtG EGP Major facilitator Superfamily
HGMPKFMI_00277 2.6e-56
HGMPKFMI_00279 6.1e-49 kgtP EGP Sugar (and other) transporter
HGMPKFMI_00280 5.3e-100 kgtP EGP Sugar (and other) transporter
HGMPKFMI_00281 2.2e-309 ybiT S ABC transporter, ATP-binding protein
HGMPKFMI_00282 3.5e-166 mleP3 S Membrane transport protein
HGMPKFMI_00283 0.0 ppc 4.1.1.31 H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HGMPKFMI_00284 6.2e-68 mtlD 1.1.1.17 C mannitol-1-phosphate 5-dehydrogenase activity
HGMPKFMI_00286 6.7e-51 mtlR K transcriptional antiterminator
HGMPKFMI_00287 0.0 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
HGMPKFMI_00288 1.2e-85 K AsnC family
HGMPKFMI_00289 9e-17 ypaA S membrane
HGMPKFMI_00290 4.4e-26 maa 2.3.1.18, 2.3.1.79 S Maltose acetyltransferase
HGMPKFMI_00292 2.5e-29 yliE T Putative diguanylate phosphodiesterase
HGMPKFMI_00293 9.3e-102 T Gaf domain
HGMPKFMI_00294 6.7e-95 nudC 1.3.7.1, 3.6.1.22 L NUDIX domain
HGMPKFMI_00295 9.9e-123 alkD L DNA alkylation repair enzyme
HGMPKFMI_00296 1.5e-239 brnQ U Component of the transport system for branched-chain amino acids
HGMPKFMI_00297 6.9e-57 flp 4.1.99.16, 4.2.3.22, 4.2.3.75 K Transcriptional regulator, Crp Fnr family
HGMPKFMI_00298 3.3e-25 flp 4.1.99.16, 4.2.3.22, 4.2.3.75 K Transcriptional regulator, Crp Fnr family
HGMPKFMI_00299 6.4e-47 D Di-iron-containing protein involved in the repair of iron-sulfur clusters
HGMPKFMI_00300 2.1e-32 copZ P Heavy-metal-associated domain
HGMPKFMI_00301 0.0 cadA 3.6.3.3, 3.6.3.5 P P-type ATPase
HGMPKFMI_00302 1.1e-69 carB 6.3.5.5 C carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HGMPKFMI_00303 4.3e-44 carB 6.3.5.5 F Carbamoyl-phosphate synthase
HGMPKFMI_00304 1.2e-32 carB 6.3.5.5 F Carbamoyl-phosphate synthase
HGMPKFMI_00305 2.2e-119 cah 4.2.1.1 P Eukaryotic-type carbonic anhydrase
HGMPKFMI_00306 3.7e-148 L Mrr N-terminal domain
HGMPKFMI_00307 4.8e-257 rumA 2.1.1.190 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HGMPKFMI_00308 1.4e-117 S Protein of unknown function (DUF1211)
HGMPKFMI_00309 1.5e-169 yegS 2.7.1.107 G Lipid kinase
HGMPKFMI_00310 3.5e-274 gatB 6.1.1.12, 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HGMPKFMI_00311 7.9e-266 gatA 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
HGMPKFMI_00312 1.8e-47 gatC 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HGMPKFMI_00313 9.2e-193 camS S sex pheromone
HGMPKFMI_00314 0.0 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HGMPKFMI_00315 0.0 pcrA 3.6.4.12 L ATP-dependent DNA helicase
HGMPKFMI_00316 1.3e-114 acmC 3.2.1.17, 3.2.1.96 NU mannosyl-glycoprotein
HGMPKFMI_00317 9.1e-102 S ECF transporter, substrate-specific component
HGMPKFMI_00319 1.8e-89 ydcK S Belongs to the SprT family
HGMPKFMI_00320 1.1e-107 V ABC transporter
HGMPKFMI_00321 2.9e-11
HGMPKFMI_00323 0.0 pacL 3.6.3.8 P P-type ATPase
HGMPKFMI_00324 3.3e-152 nadE 6.3.1.5 F Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
HGMPKFMI_00325 4.1e-135 M Glycosyltransferase sugar-binding region containing DXD motif
HGMPKFMI_00326 1e-204 csaB M Glycosyl transferases group 1
HGMPKFMI_00327 1.4e-133 tagA 2.4.1.187 GT26 F Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid
HGMPKFMI_00328 1.7e-260 epsU S Polysaccharide biosynthesis protein
HGMPKFMI_00329 4.2e-222 M CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
HGMPKFMI_00330 3.9e-125 gntR1 K UTRA
HGMPKFMI_00331 2.1e-199
HGMPKFMI_00332 2.9e-215
HGMPKFMI_00333 9e-67 oppA2 E ABC transporter, substratebinding protein
HGMPKFMI_00334 2.9e-101 oppA2 E ABC transporter, substratebinding protein
HGMPKFMI_00335 3.3e-10 oppA2 E ABC transporter, substratebinding protein
HGMPKFMI_00338 4.1e-163 pfoS S Phosphotransferase system, EIIC
HGMPKFMI_00339 3.2e-225 patA 2.6.1.1, 2.6.1.57 E Aminotransferase
HGMPKFMI_00342 4.6e-205 pbpX1 V Beta-lactamase
HGMPKFMI_00343 1.9e-14 L Helix-turn-helix domain
HGMPKFMI_00344 6e-45
HGMPKFMI_00345 1.6e-172
HGMPKFMI_00346 1.8e-90 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HGMPKFMI_00347 7.2e-112 rsmC 2.1.1.172 J Methyltransferase
HGMPKFMI_00348 2.2e-90 tadA 3.5.4.33 F Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
HGMPKFMI_00349 1.6e-287 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HGMPKFMI_00350 3.5e-52 yaaK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HGMPKFMI_00351 1.5e-106 recR L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HGMPKFMI_00352 1.4e-34 S Protein of unknown function (DUF2508)
HGMPKFMI_00353 2.4e-113 tmk 2.7.4.9 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HGMPKFMI_00354 2.4e-53 yaaQ S Cyclic-di-AMP receptor
HGMPKFMI_00355 1.6e-160 holB 2.7.7.7 L DNA polymerase III
HGMPKFMI_00356 9.9e-55 yabA L Involved in initiation control of chromosome replication
HGMPKFMI_00357 3.8e-159 rsmI 2.1.1.198 H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HGMPKFMI_00358 2.1e-145 fat 3.1.2.21 I Acyl-ACP thioesterase
HGMPKFMI_00359 3.4e-89 folT S ECF transporter, substrate-specific component
HGMPKFMI_00360 6.8e-90 folT S ECF transporter, substrate-specific component
HGMPKFMI_00361 1.2e-126 yeaZ 2.3.1.234 O Universal bacterial protein YeaZ
HGMPKFMI_00362 3.1e-95 rimI 2.3.1.128 K Ribosomal-protein-alanine acetyltransferase
HGMPKFMI_00363 7.6e-194 tsaD 2.3.1.234 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HGMPKFMI_00364 2.1e-303 uup S ABC transporter, ATP-binding protein
HGMPKFMI_00365 1.3e-122 rex K Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HGMPKFMI_00366 8.8e-44 groS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HGMPKFMI_00367 1.3e-290 groL O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
HGMPKFMI_00368 0.0 mutS L that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HGMPKFMI_00369 0.0 mutL L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HGMPKFMI_00370 9.2e-104 ruvA 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
HGMPKFMI_00371 1.6e-185 ruvB 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
HGMPKFMI_00372 2.7e-35 yajC U Preprotein translocase
HGMPKFMI_00373 2.9e-284 zwf 1.1.1.363, 1.1.1.49 G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HGMPKFMI_00374 6.4e-207 dinB 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HGMPKFMI_00375 4.1e-178 nrnA 3.1.13.3, 3.1.3.7 S DHHA1 domain protein
HGMPKFMI_00376 7.5e-226 cshB 3.6.4.13 JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
HGMPKFMI_00377 0.0 alaS 6.1.1.7 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HGMPKFMI_00378 5.7e-42 yrzL S Belongs to the UPF0297 family
HGMPKFMI_00379 1.8e-72 yqgF J Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HGMPKFMI_00380 1e-40 yrzB S Belongs to the UPF0473 family
HGMPKFMI_00381 0.0 mutS2 L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
HGMPKFMI_00382 2.7e-54 trxA O Belongs to the thioredoxin family
HGMPKFMI_00383 1.7e-66 yslB S Protein of unknown function (DUF2507)
HGMPKFMI_00384 2.3e-113 rdgB 3.6.1.66, 5.1.1.3 F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HGMPKFMI_00385 2.7e-149 ykuT M mechanosensitive ion channel
HGMPKFMI_00386 5.5e-10 WQ51_05790 S protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HGMPKFMI_00387 1.8e-41
HGMPKFMI_00388 5.4e-214 pepQ 3.4.13.9 E Creatinase/Prolidase N-terminal domain
HGMPKFMI_00389 4.9e-182 ccpA K catabolite control protein A
HGMPKFMI_00390 5.6e-58
HGMPKFMI_00391 2.7e-279 yunD 3.1.3.5 F Belongs to the 5'-nucleotidase family
HGMPKFMI_00392 1.9e-82 yutD S Protein of unknown function (DUF1027)
HGMPKFMI_00393 4.1e-144 nagD 2.7.1.25, 3.1.3.41 G Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
HGMPKFMI_00394 3.5e-106 S Protein of unknown function (DUF1461)
HGMPKFMI_00395 8.6e-119 dedA S SNARE-like domain protein
HGMPKFMI_00396 1e-184 yumC 1.18.1.2, 1.19.1.1, 1.8.1.9 C Ferredoxin--NADP reductase
HGMPKFMI_00397 6.5e-263 oppA2 E Bacterial extracellular solute-binding proteins, family 5 Middle
HGMPKFMI_00398 5.5e-121 WQ51_05710 S Mitochondrial biogenesis AIM24
HGMPKFMI_00400 1.1e-84 L DDE superfamily endonuclease
HGMPKFMI_00401 1.6e-33 lysR7 K LysR substrate binding domain
HGMPKFMI_00402 1.4e-129 3.1.21.3 V Type I restriction modification DNA specificity domain
HGMPKFMI_00403 3.2e-172 L Belongs to the 'phage' integrase family
HGMPKFMI_00404 1e-141 3.1.21.3 V Type I restriction modification DNA specificity domain
HGMPKFMI_00405 1.3e-293 hsdM 2.1.1.72 V type I restriction-modification system
HGMPKFMI_00406 0.0 hsdR 3.1.21.3 V Subunit R is required for both nuclease and ATPase activities, but not for modification
HGMPKFMI_00407 2.3e-92 GM NmrA-like family
HGMPKFMI_00408 1.9e-20 S Domain of unknown function (DUF4343)
HGMPKFMI_00410 2.2e-124 T Diguanylate cyclase, GGDEF domain
HGMPKFMI_00411 5.3e-72 S Sel1-like repeats.
HGMPKFMI_00412 2.9e-194 S Uncharacterized protein conserved in bacteria (DUF2325)
HGMPKFMI_00413 4.9e-210 glxK 2.7.1.165 G Belongs to the glycerate kinase type-1 family
HGMPKFMI_00414 3e-201 xerS L Belongs to the 'phage' integrase family
HGMPKFMI_00416 1.5e-25 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
HGMPKFMI_00417 1e-44 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
HGMPKFMI_00418 6e-91 C Nitroreductase family
HGMPKFMI_00419 4.7e-13 XK27_06780 V ABC transporter permease
HGMPKFMI_00420 1.4e-115 3.1.3.73 G phosphoglycerate mutase
HGMPKFMI_00421 7.9e-59 serC 2.6.1.52 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HGMPKFMI_00422 1.3e-111 serC 2.6.1.52 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HGMPKFMI_00423 3.1e-84 serA 1.1.1.399, 1.1.1.95 EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HGMPKFMI_00424 1.8e-119 serA 1.1.1.399, 1.1.1.95 EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HGMPKFMI_00425 1.3e-165 EG EamA-like transporter family
HGMPKFMI_00426 8.9e-182
HGMPKFMI_00427 6.3e-157 degV S EDD domain protein, DegV family
HGMPKFMI_00428 1.1e-306 FbpA K Fibronectin-binding protein
HGMPKFMI_00429 2.9e-246 XK27_08635 S UPF0210 protein
HGMPKFMI_00430 5.6e-43 gcvR T Belongs to the UPF0237 family
HGMPKFMI_00431 0.0 carB1 6.3.5.5 F Carbamoyl-phosphate synthase
HGMPKFMI_00432 3.3e-197 carA 6.3.5.5 F Carbamoyl-phosphate synthetase glutamine chain
HGMPKFMI_00433 1e-170 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
HGMPKFMI_00434 9.3e-72 lspA 3.4.23.36 MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HGMPKFMI_00435 0.0 fhs 6.3.4.3 F Belongs to the formate--tetrahydrofolate ligase family
HGMPKFMI_00436 6e-58
HGMPKFMI_00437 4.5e-126 XK27_01810 S Calcineurin-like phosphoesterase
HGMPKFMI_00438 8.7e-220 rlmL 2.1.1.173, 2.1.1.264 L Belongs to the methyltransferase superfamily
HGMPKFMI_00439 1e-57 gpsB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
HGMPKFMI_00440 3.2e-106 ypsA S Belongs to the UPF0398 family
HGMPKFMI_00441 2e-117 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
HGMPKFMI_00442 0.0 ponA 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein 1A
HGMPKFMI_00443 0.0 dap2 3.4.19.1 E Prolyl oligopeptidase family
HGMPKFMI_00444 2.4e-189 ldhA 1.1.1.28 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HGMPKFMI_00445 5.5e-54 I acetylesterase activity
HGMPKFMI_00446 2.1e-70 I Psort location Cytoplasmic, score
HGMPKFMI_00447 6.8e-150 S Sucrose-6F-phosphate phosphohydrolase
HGMPKFMI_00448 6.1e-114 nth 4.2.99.18 L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HGMPKFMI_00449 9.7e-115 dnaD L DnaD domain protein
HGMPKFMI_00451 3.7e-34 oppA E ABC transporter, substratebinding protein
HGMPKFMI_00452 2.4e-30 oppA E ABC transporter, substratebinding protein
HGMPKFMI_00453 4.7e-106 oppA E ABC transporter, substratebinding protein
HGMPKFMI_00454 1.9e-13 oppA E ABC transporter, substratebinding protein
HGMPKFMI_00455 2e-36
HGMPKFMI_00456 6.9e-59 yliE T Putative diguanylate phosphodiesterase
HGMPKFMI_00457 5e-15 yliE T GGDEF domain
HGMPKFMI_00459 9.1e-156 pstS P Phosphate
HGMPKFMI_00460 1.1e-161 pstC P probably responsible for the translocation of the substrate across the membrane
HGMPKFMI_00461 2.8e-157 pstA P Phosphate transport system permease protein PstA
HGMPKFMI_00462 3.2e-141 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
HGMPKFMI_00463 1.8e-113 phoU P Plays a role in the regulation of phosphate uptake
HGMPKFMI_00464 1.4e-124 T Transcriptional regulatory protein, C terminal
HGMPKFMI_00465 1.2e-302 phoR 2.7.13.3 T Histidine kinase
HGMPKFMI_00466 2.4e-21 cbh 3.5.1.24 M Linear amide C-N hydrolases, choloylglycine hydrolase family
HGMPKFMI_00467 2.1e-34 cbh 3.5.1.24 M Linear amide C-N hydrolases, choloylglycine hydrolase family
HGMPKFMI_00468 6.1e-84 lsa S ABC transporter
HGMPKFMI_00470 7e-121 3.6.1.13 L NUDIX domain
HGMPKFMI_00471 1.5e-46 S Glycosyl hydrolases family 18
HGMPKFMI_00472 7.6e-129 S Glycosyl hydrolases family 18
HGMPKFMI_00473 8e-102 I NUDIX domain
HGMPKFMI_00474 3.2e-43 S C4-dicarboxylate anaerobic carrier
HGMPKFMI_00475 4.2e-141 cbiO2 P ABC transporter
HGMPKFMI_00476 1.5e-149 P ABC transporter
HGMPKFMI_00477 7.8e-135 cbiQ P Cobalt transport protein
HGMPKFMI_00478 8.4e-103 2.7.7.65 T phosphorelay sensor kinase activity
HGMPKFMI_00480 5e-290 yliE T Putative diguanylate phosphodiesterase
HGMPKFMI_00481 4.3e-155 2.7.7.65 T diguanylate cyclase
HGMPKFMI_00482 9e-104
HGMPKFMI_00483 2.1e-151 supH G Sucrose-6F-phosphate phosphohydrolase
HGMPKFMI_00484 1.2e-14 K Winged helix DNA-binding domain
HGMPKFMI_00485 1.2e-43 lmrA V (ABC) transporter
HGMPKFMI_00487 1e-41 V ABC transporter, ATP-binding protein
HGMPKFMI_00488 2.8e-52 V abc transporter atp-binding protein
HGMPKFMI_00489 1.8e-184 yfiC V ABC transporter
HGMPKFMI_00490 7.6e-31 yfiC V ABC transporter
HGMPKFMI_00491 3.2e-102 plsY 2.3.1.15, 3.5.1.104 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
HGMPKFMI_00492 0.0 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HGMPKFMI_00493 0.0 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HGMPKFMI_00494 1.4e-170 ppaC 3.6.1.1 C inorganic pyrophosphatase
HGMPKFMI_00495 1.8e-192 fni 1.1.1.88, 5.3.3.2 C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
HGMPKFMI_00496 1.7e-201 mvaK2 2.7.1.36, 2.7.1.43, 2.7.4.2 I phosphomevalonate kinase
HGMPKFMI_00497 2.3e-176 mvaD 4.1.1.33 I diphosphomevalonate decarboxylase
HGMPKFMI_00498 8.2e-168 mvk 1.1.1.88, 2.3.3.10, 2.7.1.36 I GHMP kinases N terminal domain
HGMPKFMI_00499 0.0 rexB 3.1.21.3, 3.6.4.12 L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' - 3' nuclease activity
HGMPKFMI_00500 0.0 addA 3.6.4.12 L ATP-dependent helicase nuclease subunit A
HGMPKFMI_00501 0.0 dinG 2.7.7.7, 3.6.4.12 L helicase involved in DNA repair and perhaps also replication
HGMPKFMI_00502 1.2e-59 ypmB S Protein conserved in bacteria
HGMPKFMI_00503 3.2e-172 glfT1 1.1.1.133 S Glycosyltransferase like family 2
HGMPKFMI_00504 5.6e-211 M Glycosyl transferases group 1
HGMPKFMI_00505 2.3e-147 M Domain of unknown function (DUF4422)
HGMPKFMI_00506 8.7e-08 wzy S EpsG family
HGMPKFMI_00507 1.6e-263 epsIIL S Membrane protein involved in the export of O-antigen and teichoic acid
HGMPKFMI_00508 2.4e-180 M LicD family
HGMPKFMI_00509 5.7e-85 tagD 2.7.7.15, 2.7.7.39 IM Glycerol-3-phosphate cytidylyltransferase
HGMPKFMI_00510 3.2e-73 S Bacterial membrane protein, YfhO
HGMPKFMI_00512 8.1e-15 I transferase activity, transferring acyl groups other than amino-acyl groups
HGMPKFMI_00513 4.6e-79 S VanZ like family
HGMPKFMI_00514 2.7e-73 mesH S Teichoic acid glycosylation protein
HGMPKFMI_00515 2.2e-128 S VanZ like family
HGMPKFMI_00516 7.9e-42 sidC L DNA recombination
HGMPKFMI_00517 1.9e-107 L DNA recombination
HGMPKFMI_00518 1.3e-10 sidC L DNA recombination
HGMPKFMI_00519 0.0 3.1.4.46, 3.2.1.99 GH43 N domain, Protein
HGMPKFMI_00521 3.4e-134 glpQ1 3.1.4.46 C glycerophosphoryl diester phosphodiesterase
HGMPKFMI_00522 1.2e-123 pgm3 G Phosphoglycerate mutase family
HGMPKFMI_00523 6.4e-114 XK27_08875 O PFAM peptidase M10A and M12B, matrixin and adamalysin
HGMPKFMI_00524 0.0 helD 3.6.4.12 L DNA helicase
HGMPKFMI_00525 1.4e-30 aatB ET ABC transporter substrate-binding protein
HGMPKFMI_00526 8.8e-72 aatB ET ABC transporter substrate-binding protein
HGMPKFMI_00527 1e-11 liaI S membrane
HGMPKFMI_00528 4.4e-74 XK27_02470 K LytTr DNA-binding domain
HGMPKFMI_00529 9.8e-103 E GDSL-like Lipase/Acylhydrolase
HGMPKFMI_00530 1e-170 coaA 2.7.1.33 F Pantothenic acid kinase
HGMPKFMI_00531 1.4e-98 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HGMPKFMI_00532 1.6e-76 ymfM S Helix-turn-helix domain
HGMPKFMI_00533 1.1e-180 pip 3.4.11.5 E Releases the N-terminal proline from various substrates
HGMPKFMI_00534 1.2e-197
HGMPKFMI_00535 6.8e-71 L COG2826 Transposase and inactivated derivatives, IS30 family
HGMPKFMI_00536 1.9e-52 L transposase and inactivated derivatives, IS30 family
HGMPKFMI_00537 3.3e-289 V ABC transporter transmembrane region
HGMPKFMI_00538 6e-09 S PAS domain
HGMPKFMI_00539 8.6e-47 GK ROK family
HGMPKFMI_00540 1.9e-33 GK ROK family
HGMPKFMI_00542 1.7e-156 dkg S reductase
HGMPKFMI_00543 3e-124 endA F DNA RNA non-specific endonuclease
HGMPKFMI_00544 1e-41 E dipeptidase activity
HGMPKFMI_00545 4.4e-106
HGMPKFMI_00546 6e-85 paiA 2.3.1.57 K Acetyltransferase (GNAT) domain
HGMPKFMI_00547 4.6e-176 pepI 3.4.11.5, 3.5.1.101 E Releases the N-terminal proline from various substrates
HGMPKFMI_00548 6.7e-154 corA P CorA-like Mg2+ transporter protein
HGMPKFMI_00549 1e-157 3.5.2.6 V Beta-lactamase enzyme family
HGMPKFMI_00550 5.5e-26
HGMPKFMI_00551 2.3e-99 yobS K Bacterial regulatory proteins, tetR family
HGMPKFMI_00552 0.0 ydgH S MMPL family
HGMPKFMI_00553 2.6e-176
HGMPKFMI_00554 8.4e-198 asnA 6.3.1.1 F aspartate--ammonia ligase
HGMPKFMI_00555 9.2e-30 dedA 3.1.3.1 S SNARE associated Golgi protein
HGMPKFMI_00557 1.8e-84
HGMPKFMI_00558 8.4e-81 K GNAT family
HGMPKFMI_00559 0.0 prtS 3.4.21.110, 3.4.21.96 O Belongs to the peptidase S8 family
HGMPKFMI_00560 1.5e-227 4.4.1.8 E Aminotransferase, class I
HGMPKFMI_00561 3.4e-166 htpX O Peptidase family M48
HGMPKFMI_00562 9.4e-93 1.6.5.2 GM NmrA-like family
HGMPKFMI_00563 9.3e-16 1.6.5.2 GM NAD(P)H-binding
HGMPKFMI_00564 3e-78 K Transcriptional regulator
HGMPKFMI_00565 2.3e-170 E ABC transporter, ATP-binding protein
HGMPKFMI_00566 3.2e-278 proWX EM Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
HGMPKFMI_00567 2.3e-265 gapN 1.2.1.9 C Belongs to the aldehyde dehydrogenase family
HGMPKFMI_00568 2e-123 metA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to
HGMPKFMI_00569 2.1e-137 prsW S Involved in the degradation of specific anti-sigma factors
HGMPKFMI_00570 8.9e-110 pcp 3.4.19.3 O Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HGMPKFMI_00571 6.3e-25
HGMPKFMI_00572 4.2e-138
HGMPKFMI_00573 1.1e-173
HGMPKFMI_00574 2.8e-263 rsmF 2.1.1.176 J NOL1 NOP2 sun family protein
HGMPKFMI_00575 1.6e-157 3.4.17.13 V LD-carboxypeptidase
HGMPKFMI_00576 7.3e-14 S Fic/DOC family
HGMPKFMI_00577 3.1e-07 D Filamentation induced by cAMP protein fic
HGMPKFMI_00578 0.0 L Type III restriction enzyme, res subunit
HGMPKFMI_00579 9.9e-132 2.1.1.72 V site-specific DNA-methyltransferase (adenine-specific) activity
HGMPKFMI_00580 1.3e-107 pat 2.3.1.183 M Acetyltransferase (GNAT) domain
HGMPKFMI_00581 1.7e-142 ydcF S Gram-negative-bacterium-type cell wall biogenesis
HGMPKFMI_00582 3.4e-106 yyaQ S YjbR
HGMPKFMI_00583 5.2e-147 ligA 2.7.7.7, 6.5.1.2 L EXOIII
HGMPKFMI_00584 9.3e-214 pbpX1 V Beta-lactamase
HGMPKFMI_00585 1.6e-39 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
HGMPKFMI_00586 3e-19 rpiB 5.3.1.6 G Ribose/Galactose Isomerase
HGMPKFMI_00587 3.8e-11 rpiB 5.3.1.6 G Ribose/Galactose Isomerase
HGMPKFMI_00589 2.5e-57 apbE 2.7.1.180 H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
HGMPKFMI_00590 4e-27 P nitric oxide dioxygenase activity
HGMPKFMI_00591 1.5e-143 oppA E ABC transporter, substratebinding protein
HGMPKFMI_00592 3.3e-86 oppA E ABC transporter, substratebinding protein
HGMPKFMI_00593 1.8e-49 rplL J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
HGMPKFMI_00594 1.1e-81 rplJ J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HGMPKFMI_00595 3.1e-237 L Putative transposase DNA-binding domain
HGMPKFMI_00596 8.5e-69
HGMPKFMI_00597 3.5e-230 amtB P ammonium transporter
HGMPKFMI_00598 9.2e-189 S Glycosyl transferase family 2
HGMPKFMI_00599 2e-121 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
HGMPKFMI_00600 6.9e-69 rplK J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HGMPKFMI_00601 5.2e-101 nusG K Participates in transcription elongation, termination and antitermination
HGMPKFMI_00602 1.8e-23 secE U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
HGMPKFMI_00603 1e-19 rpmG J Belongs to the bacterial ribosomal protein bL33 family
HGMPKFMI_00604 1.5e-129 dxs 2.2.1.7 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HGMPKFMI_00605 2.4e-95 dxs 2.2.1.7 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HGMPKFMI_00606 1.3e-97 4.2.99.20 S Alpha/beta hydrolase family
HGMPKFMI_00607 1.8e-33
HGMPKFMI_00608 2.4e-101 yvrI K sigma factor activity
HGMPKFMI_00609 2.5e-138 rlmB 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HGMPKFMI_00610 9.4e-77 mrnC J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HGMPKFMI_00611 2.2e-276 cysS 6.1.1.16, 6.3.1.13 J Belongs to the class-I aminoacyl-tRNA synthetase family
HGMPKFMI_00612 8.5e-107 F NUDIX domain
HGMPKFMI_00613 5.4e-161 K LysR substrate binding domain
HGMPKFMI_00614 7.2e-181 yeiH S Conserved hypothetical protein 698
HGMPKFMI_00615 3.3e-291 gltX 6.1.1.17, 6.1.1.24 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HGMPKFMI_00617 5.7e-121 skfE V ATPases associated with a variety of cellular activities
HGMPKFMI_00618 8.7e-60 yvoA_1 K Transcriptional regulator, GntR family
HGMPKFMI_00620 1.4e-265 oppA2 E Bacterial extracellular solute-binding proteins, family 5 Middle
HGMPKFMI_00621 2.4e-127 WQ51_05710 S Mitochondrial biogenesis AIM24
HGMPKFMI_00622 3.5e-71 K Transcriptional regulator
HGMPKFMI_00623 8.8e-47 GM epimerase
HGMPKFMI_00624 1.1e-19 S Protein of unknown function N-terminus (DUF3323)
HGMPKFMI_00627 0.0 yacH D Putative exonuclease SbcCD, C subunit
HGMPKFMI_00628 5.4e-57
HGMPKFMI_00629 2.9e-58 S transferase hexapeptide repeat
HGMPKFMI_00630 3.8e-93 S Hydrolases of the alpha beta superfamily
HGMPKFMI_00631 3.7e-43 ylbE GM NAD(P)H-binding
HGMPKFMI_00632 3.4e-61 ylbE GM NAD(P)H-binding
HGMPKFMI_00633 5.9e-46 V (ABC) transporter
HGMPKFMI_00634 4.1e-167 V Psort location CytoplasmicMembrane, score 10.00
HGMPKFMI_00635 5.4e-77 V Psort location CytoplasmicMembrane, score
HGMPKFMI_00636 9.7e-112 1.1.1.399, 1.1.1.95 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HGMPKFMI_00637 2.3e-78 K Transcriptional regulator, MarR family
HGMPKFMI_00638 1.7e-307 XK27_09600 V ABC transporter, ATP-binding protein
HGMPKFMI_00639 0.0 V ABC transporter transmembrane region
HGMPKFMI_00640 9.5e-52 P Rhodanese Homology Domain
HGMPKFMI_00641 3.9e-65 rnhA 3.1.26.4 L RNA-DNA hybrid ribonuclease activity
HGMPKFMI_00642 5.7e-172 rnhA 3.1.26.4 L Resolvase, N-terminal
HGMPKFMI_00643 6.7e-47 rnhA 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HGMPKFMI_00645 9.1e-43 yjdJ S GCN5-related N-acetyl-transferase
HGMPKFMI_00646 1.8e-133 gph 3.1.3.18 S HAD-hyrolase-like
HGMPKFMI_00647 2.4e-133 C FAD binding domain
HGMPKFMI_00648 6.1e-282 oppA E ABC transporter, substratebinding protein
HGMPKFMI_00649 3.8e-93 3.6.1.13 L COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
HGMPKFMI_00650 1.1e-233 6.3.2.4 F Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HGMPKFMI_00651 1.1e-225 6.3.4.18, 6.3.5.5 F 5-(carboxyamino)imidazole ribonucleotide synthase activity
HGMPKFMI_00652 4.2e-158 rfbA 2.7.7.24 H Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HGMPKFMI_00653 8.6e-201
HGMPKFMI_00654 4.6e-211 EGP Transmembrane secretion effector
HGMPKFMI_00655 4.6e-213 pepQ 3.4.13.9 E Creatinase/Prolidase N-terminal domain
HGMPKFMI_00656 3.4e-73 2.7.13.3 T diguanylate cyclase
HGMPKFMI_00657 1.5e-20 5.99.1.2 T diguanylate cyclase
HGMPKFMI_00658 3.7e-16 5.99.1.2 T diguanylate cyclase
HGMPKFMI_00659 1.8e-110 T EAL domain
HGMPKFMI_00660 1.3e-11 5.99.1.2 T diguanylate cyclase
HGMPKFMI_00661 1.4e-84 S ECF-type riboflavin transporter, S component
HGMPKFMI_00662 3e-113 adhE 1.1.1.1, 1.2.1.10 C Aldehyde dehydrogenase family
HGMPKFMI_00663 2.1e-111 adhE 1.1.1.1, 1.2.1.10 C Aldehyde dehydrogenase family
HGMPKFMI_00664 3.3e-144 cbiQ P cobalt transport
HGMPKFMI_00665 0.0 ykoD P ABC transporter, ATP-binding protein
HGMPKFMI_00666 7.6e-100 S UPF0397 protein
HGMPKFMI_00667 7.6e-160 salL 2.5.1.63, 2.5.1.94 K S-adenosyl-l-methionine hydroxide adenosyltransferase
HGMPKFMI_00668 6.6e-254 cycA E Amino acid permease
HGMPKFMI_00669 0.0 S ABC-type transport system involved in multi-copper enzyme maturation permease component
HGMPKFMI_00670 9.6e-169 ytrB V ABC transporter
HGMPKFMI_00671 2.2e-58 ytrA K helix_turn_helix gluconate operon transcriptional repressor
HGMPKFMI_00674 7.5e-39 S SLAP domain
HGMPKFMI_00675 1.7e-104 ydaF J Acetyltransferase (GNAT) domain
HGMPKFMI_00676 1.8e-164 1.3.5.4 C FAD binding domain
HGMPKFMI_00677 7.3e-83 1.3.5.4 C FAD binding domain
HGMPKFMI_00678 5.4e-13 XK26_02160 C Pyridoxamine 5'-phosphate oxidase
HGMPKFMI_00679 0.0 V FtsX-like permease family
HGMPKFMI_00680 3.3e-130 cysA V ABC transporter, ATP-binding protein
HGMPKFMI_00682 4.5e-70 arsC 1.20.4.1 T Low molecular weight phosphotyrosine protein phosphatase
HGMPKFMI_00683 6e-76
HGMPKFMI_00684 1.4e-72 S Psort location CytoplasmicMembrane, score
HGMPKFMI_00685 1e-13 cylB V ABC-2 type transporter
HGMPKFMI_00686 4.4e-75 cylB U ABC-2 type transporter
HGMPKFMI_00687 1.2e-105 L Integrase
HGMPKFMI_00688 1.1e-73 3.6.4.12 K Putative ATP-dependent DNA helicase recG C-terminal
HGMPKFMI_00689 6.1e-73 prpH 3.1.3.16 K 3.5.2 Transcription regulation
HGMPKFMI_00690 1.7e-164 V MATE efflux family protein
HGMPKFMI_00691 3.5e-34 V drug transmembrane transporter activity
HGMPKFMI_00693 8.6e-37 T diguanylate cyclase activity
HGMPKFMI_00694 8.2e-196 carA 6.3.5.5 F Carbamoyl-phosphate synthetase glutamine chain
HGMPKFMI_00695 1.7e-272 carB 6.3.5.5 F Psort location Cytoplasmic, score 8.87
HGMPKFMI_00696 2.3e-255 carB 6.3.5.5 F Psort location Cytoplasmic, score 8.87
HGMPKFMI_00697 3.7e-14 ybaJ Q Methyltransferase domain protein
HGMPKFMI_00700 9.2e-73 cydD V abc transporter atp-binding protein
HGMPKFMI_00701 1.4e-275 sufB O assembly protein SufB
HGMPKFMI_00702 4.3e-74 nifU C SUF system FeS assembly protein, NifU family
HGMPKFMI_00703 4.3e-225 sufS 2.8.1.7, 4.4.1.16 E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HGMPKFMI_00704 4e-220 sufD O FeS assembly protein SufD
HGMPKFMI_00705 5.9e-143 sufC O FeS assembly ATPase SufC
HGMPKFMI_00706 6e-91 yjcF S Acetyltransferase (GNAT) domain
HGMPKFMI_00707 5.1e-84 pts23A G phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1
HGMPKFMI_00708 5.3e-81
HGMPKFMI_00709 4.5e-20 aglB 3.2.1.122, 3.2.1.86 GH4,GT4 G Family 4 glycosyl hydrolase C-terminal domain
HGMPKFMI_00711 4.9e-117 V ABC transporter, ATP-binding protein
HGMPKFMI_00712 1.9e-215 S FtsX-like permease family
HGMPKFMI_00715 8e-79 smpB J the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
HGMPKFMI_00716 0.0 rnr J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
HGMPKFMI_00717 2.9e-29 secG U Preprotein translocase
HGMPKFMI_00718 0.0 ltaS 2.7.8.20 M Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
HGMPKFMI_00719 3.3e-178 mprF S Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HGMPKFMI_00720 2.2e-201 cpoA GT4 M Glycosyltransferase, group 1 family protein
HGMPKFMI_00721 5.8e-219 mgs 2.4.1.337 GT4 M Glycosyl transferase 4-like domain
HGMPKFMI_00724 2.5e-91 S Phosphatidylethanolamine-binding protein
HGMPKFMI_00725 1.3e-58 EGP Major facilitator Superfamily
HGMPKFMI_00726 1.6e-37 EGP Major facilitator Superfamily
HGMPKFMI_00727 4.3e-120 XK27_07525 3.6.1.55 F NUDIX domain
HGMPKFMI_00728 1.2e-12 oppA E ABC transporter, substratebinding protein
HGMPKFMI_00729 3.4e-68 oppA E ABC transporter, substratebinding protein
HGMPKFMI_00730 6.1e-142 oppA E ABC transporter, substratebinding protein
HGMPKFMI_00731 1.6e-45
HGMPKFMI_00732 1.9e-65 rpsI J Belongs to the universal ribosomal protein uS9 family
HGMPKFMI_00733 4.2e-77 rplM J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HGMPKFMI_00734 6e-151 truA 5.4.99.12 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
HGMPKFMI_00735 3e-142 ecfT U Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HGMPKFMI_00736 1.3e-162 ecfA 3.6.3.55 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HGMPKFMI_00737 1.6e-154 ecfA1 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HGMPKFMI_00738 1.3e-61 rplQ J Ribosomal protein L17
HGMPKFMI_00739 5.6e-172 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HGMPKFMI_00740 1.4e-63 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HGMPKFMI_00741 4.2e-56 rpsM J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HGMPKFMI_00742 8.4e-34 infA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HGMPKFMI_00743 5.9e-120 adk 2.7.4.3 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
HGMPKFMI_00744 1.1e-237 secY U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
HGMPKFMI_00745 1.8e-72 rplO J Binds to the 23S rRNA
HGMPKFMI_00746 1.3e-24 rpmD J Ribosomal protein L30
HGMPKFMI_00747 1.3e-85 rpsE J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HGMPKFMI_00748 5.7e-56 rplR J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HGMPKFMI_00749 2.8e-91 rplF J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HGMPKFMI_00750 7.2e-68 rpsH J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HGMPKFMI_00751 9.3e-95 rplE J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HGMPKFMI_00752 1e-32 rplX J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HGMPKFMI_00753 1.6e-58 rplN J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HGMPKFMI_00754 3.8e-41 rpsQ J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HGMPKFMI_00755 3.7e-25 rpmC J Belongs to the universal ribosomal protein uL29 family
HGMPKFMI_00756 1.9e-77 rplP J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HGMPKFMI_00757 9.4e-121 rpsC J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HGMPKFMI_00758 8.9e-54 rplV J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HGMPKFMI_00759 4.5e-45 rpsS J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HGMPKFMI_00760 2.8e-154 rplB J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HGMPKFMI_00761 8.3e-45 rplW J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
HGMPKFMI_00762 1.6e-106 rplD J Forms part of the polypeptide exit tunnel
HGMPKFMI_00763 1.8e-110 rplC J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HGMPKFMI_00764 1.2e-49 rpsJ J Involved in the binding of tRNA to the ribosomes
HGMPKFMI_00765 0.0 fusA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HGMPKFMI_00766 3.5e-82 rpsG J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
HGMPKFMI_00767 1e-69 rpsL J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HGMPKFMI_00768 9e-08 pilD 3.4.23.43 NOU Bacterial Peptidase A24 N-terminal domain
HGMPKFMI_00769 0.0 rpoC 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HGMPKFMI_00770 0.0 rpoB 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HGMPKFMI_00773 0.0 clpC O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
HGMPKFMI_00774 2.7e-82 yebR 1.8.4.14 T GAF domain-containing protein
HGMPKFMI_00778 3.7e-108 XK27_00160 S Domain of unknown function (DUF5052)
HGMPKFMI_00779 2.1e-213 metY 2.5.1.49 E Catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol
HGMPKFMI_00780 4.1e-22 metY 2.5.1.49 E o-acetylhomoserine
HGMPKFMI_00782 2.3e-139 T diguanylate cyclase activity
HGMPKFMI_00784 2.5e-278 lysS 6.1.1.6 J Belongs to the class-II aminoacyl-tRNA synthetase family
HGMPKFMI_00785 1.1e-197 dus J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HGMPKFMI_00786 2.9e-251 pepT2 3.4.11.14, 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
HGMPKFMI_00787 4.7e-296 E ABC transporter, substratebinding protein
HGMPKFMI_00788 5.3e-164 hslO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HGMPKFMI_00789 0.0 ftsH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HGMPKFMI_00790 7.8e-249 tilS 2.4.2.8, 6.3.4.19 J Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
HGMPKFMI_00791 2.2e-60 yabR J S1 RNA binding domain
HGMPKFMI_00792 1.5e-59 divIC D Septum formation initiator
HGMPKFMI_00793 3.2e-34 yabO J S4 domain protein
HGMPKFMI_00794 0.0 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HGMPKFMI_00795 1.1e-103 pth 3.1.1.29 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
HGMPKFMI_00796 2e-126 S (CBS) domain
HGMPKFMI_00797 6.9e-217 alr 5.1.1.1 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HGMPKFMI_00798 9.4e-71 acpS 2.7.6.3, 2.7.8.7, 5.1.1.1 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
HGMPKFMI_00799 8.2e-239 cshA 3.6.4.13 F DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
HGMPKFMI_00800 2.7e-260 murF 6.3.2.10 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
HGMPKFMI_00801 1.6e-41 rpmE2 J Ribosomal protein L31
HGMPKFMI_00802 1.3e-240 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HGMPKFMI_00803 0.0 pyrG 6.3.4.2 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
HGMPKFMI_00804 1.1e-64 rpoE K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
HGMPKFMI_00805 2.5e-65 S Domain of unknown function (DUF1934)
HGMPKFMI_00806 1.4e-253 ywfO S Metal dependent phosphohydrolases with conserved 'HD' motif.
HGMPKFMI_00807 6.7e-176 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HGMPKFMI_00808 1.3e-41
HGMPKFMI_00809 1.8e-251 glmU 2.3.1.157, 2.7.7.23 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HGMPKFMI_00810 1.6e-149 purR 2.4.2.22, 2.4.2.7 F pur operon repressor
HGMPKFMI_00811 6.4e-38 veg S Biofilm formation stimulator VEG
HGMPKFMI_00812 3e-159 ksgA 2.1.1.182 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
HGMPKFMI_00813 2.1e-97 rnmV 3.1.26.8 J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HGMPKFMI_00814 1.9e-149 tatD L hydrolase, TatD family
HGMPKFMI_00815 0.0 metG 6.1.1.10 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HGMPKFMI_00816 0.0 mgtA 3.6.3.2 P COG0474 Cation transport ATPase
HGMPKFMI_00817 1.6e-103 S TPM domain
HGMPKFMI_00818 1.8e-89 comEB 3.5.4.12 F MafB19-like deaminase
HGMPKFMI_00819 3.3e-194 trpS 6.1.1.2 J Belongs to the class-I aminoacyl-tRNA synthetase family
HGMPKFMI_00821 3e-119
HGMPKFMI_00822 2.2e-52 KLT Protein kinase domain
HGMPKFMI_00823 3.8e-128 V ATPases associated with a variety of cellular activities
HGMPKFMI_00824 1.9e-136 V ABC-2 type transporter
HGMPKFMI_00825 1.8e-113 E peptidase
HGMPKFMI_00827 6.6e-29 S Enterocin A Immunity
HGMPKFMI_00828 7.5e-146 2.7.7.1, 3.6.1.55, 3.6.1.67 F NUDIX domain
HGMPKFMI_00829 2e-42 L Membrane
HGMPKFMI_00830 6.1e-102
HGMPKFMI_00831 1.3e-107 pncA Q Isochorismatase family
HGMPKFMI_00832 6e-132 L COG2826 Transposase and inactivated derivatives, IS30 family
HGMPKFMI_00833 6.5e-57 L Transposase and inactivated derivatives, IS30 family
HGMPKFMI_00834 2.7e-285 pncB 6.3.4.21 F Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HGMPKFMI_00835 2.6e-80 mscL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
HGMPKFMI_00836 6e-93 S Sucrose-6F-phosphate phosphohydrolase
HGMPKFMI_00837 4.6e-188 ansA 3.5.1.1 EJ L-asparaginase, type I
HGMPKFMI_00838 6.2e-76 K helix_turn_helix multiple antibiotic resistance protein
HGMPKFMI_00839 5.6e-52 ywhH S Aminoacyl-tRNA editing domain
HGMPKFMI_00840 1.7e-07 ywhH S Aminoacyl-tRNA editing domain
HGMPKFMI_00841 1.6e-174 mmuM 1.5.1.20, 2.1.1.10 H homocysteine S-methyltransferase
HGMPKFMI_00842 2.8e-96 mmuP E amino acid
HGMPKFMI_00843 2.5e-64 mmuP E amino acid
HGMPKFMI_00844 8.9e-165 3.6.4.12 K Putative ATP-dependent DNA helicase recG C-terminal
HGMPKFMI_00845 6.2e-251 yxbA 6.3.1.12 S ATP-grasp enzyme
HGMPKFMI_00846 7.4e-130 2.4.2.3 F Phosphorylase superfamily
HGMPKFMI_00848 4.8e-126 tcyB E ABC transporter
HGMPKFMI_00849 2e-132 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
HGMPKFMI_00850 3.8e-132 tcyA ET Belongs to the bacterial solute-binding protein 3 family
HGMPKFMI_00853 1.4e-243 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
HGMPKFMI_00854 5.1e-113 K Transcriptional regulator
HGMPKFMI_00855 2.1e-283 V ABC-type multidrug transport system, ATPase and permease components
HGMPKFMI_00856 2.2e-290 KLT Protein kinase domain
HGMPKFMI_00857 5.8e-64 S HicB family
HGMPKFMI_00858 4.9e-38 S HicA toxin of bacterial toxin-antitoxin,
HGMPKFMI_00859 2.4e-300 guaA 2.3.1.128, 6.3.5.2 F Catalyzes the synthesis of GMP from XMP
HGMPKFMI_00860 1.2e-203 guaB 1.1.1.205 F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
HGMPKFMI_00861 5e-99 xpt 2.4.2.22, 2.4.2.7 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
HGMPKFMI_00862 3.5e-225 pbuX F xanthine permease
HGMPKFMI_00863 2.6e-64
HGMPKFMI_00864 4.5e-252 uvrX 2.7.7.7 L Belongs to the DNA polymerase type-Y family
HGMPKFMI_00865 3.1e-189 guaC 1.1.1.205, 1.7.1.7 F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
HGMPKFMI_00866 4.1e-250 purA 6.3.4.4 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HGMPKFMI_00867 2.1e-79 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
HGMPKFMI_00868 2.1e-73 hsp O Belongs to the small heat shock protein (HSP20) family
HGMPKFMI_00869 1.4e-258 pepC 3.4.22.40 E Papain family cysteine protease
HGMPKFMI_00870 5.1e-256 pepC 3.4.22.40 E aminopeptidase
HGMPKFMI_00871 2.8e-179 oppF P Belongs to the ABC transporter superfamily
HGMPKFMI_00872 3.9e-198 oppD P Belongs to the ABC transporter superfamily
HGMPKFMI_00873 7.8e-183 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGMPKFMI_00874 7.5e-145 oppB P ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGMPKFMI_00875 5.6e-300 oppA E ABC transporter
HGMPKFMI_00876 3.6e-110 oppA E ABC transporter, substratebinding protein
HGMPKFMI_00877 1.6e-123 oppA E ABC transporter, substratebinding protein
HGMPKFMI_00878 1.9e-30 oppA E transmembrane transport
HGMPKFMI_00879 1.6e-291 oppA E ABC transporter, substratebinding protein
HGMPKFMI_00880 1.2e-169 oppA E ABC transporter, substratebinding protein
HGMPKFMI_00881 9.1e-62 oppA E ABC transporter, substratebinding protein
HGMPKFMI_00882 4e-19 oppA E ABC transporter, substratebinding protein
HGMPKFMI_00883 1.6e-120 ypgQ S Metal dependent phosphohydrolases with conserved 'HD' motif.
HGMPKFMI_00884 4.7e-243 N Uncharacterized conserved protein (DUF2075)
HGMPKFMI_00885 3.9e-193 mmuP E amino acid
HGMPKFMI_00886 1.2e-232 amd 3.5.1.47 E Peptidase family M20/M25/M40
HGMPKFMI_00887 1.7e-11 steT E amino acid
HGMPKFMI_00888 2.3e-60 pdxH S Pyridoxamine 5'-phosphate oxidase
HGMPKFMI_00890 1.8e-242 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HGMPKFMI_00893 5.9e-160 cjaA ET ABC transporter substrate-binding protein
HGMPKFMI_00894 3.7e-134 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
HGMPKFMI_00895 4e-79 P ABC transporter permease
HGMPKFMI_00896 6e-112 papP P ABC transporter, permease protein
HGMPKFMI_00897 2.8e-13 S Uncharacterized protein conserved in bacteria (DUF2255)
HGMPKFMI_00898 3.1e-98 3.6.1.55, 3.6.1.67 F NUDIX domain
HGMPKFMI_00899 6.7e-201 folP 2.5.1.15 H dihydropteroate synthase
HGMPKFMI_00900 1.4e-248 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
HGMPKFMI_00901 2e-202 folE 1.13.11.81, 2.5.1.15, 2.7.6.3, 3.5.4.16, 4.1.2.25, 5.1.99.8 F GTP cyclohydrolase 1
HGMPKFMI_00902 8.5e-57 folB 1.13.11.81, 2.5.1.15, 2.7.6.3, 4.1.2.25, 5.1.99.8 H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HGMPKFMI_00903 2.8e-51 S Responsible for the incorporation of O-acetyl groups into the enterobacterial common antigen (ECA) trisaccharide repeat units
HGMPKFMI_00904 0.0 XK27_08315 M Sulfatase
HGMPKFMI_00905 2.9e-108 plsY 2.3.1.15 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
HGMPKFMI_00906 1.7e-206 brpA K Cell envelope-like function transcriptional attenuator common domain protein
HGMPKFMI_00907 3.9e-130 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HGMPKFMI_00908 2e-132
HGMPKFMI_00909 1.9e-70 S Oxidoreductase
HGMPKFMI_00910 0.0 yjbQ P TrkA C-terminal domain protein
HGMPKFMI_00911 3.9e-258 atl 3.2.1.96, 3.5.1.28 GH73 M N-acetylmuramoyl-L-alanine amidase
HGMPKFMI_00912 5.7e-193 NU Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
HGMPKFMI_00913 4e-34 S Protein of unknown function (DUF2922)
HGMPKFMI_00914 1.3e-28
HGMPKFMI_00915 2.4e-85
HGMPKFMI_00916 1.7e-72
HGMPKFMI_00917 0.0 kup P Transport of potassium into the cell
HGMPKFMI_00918 0.0 pepO 3.4.24.71 O Peptidase family M13
HGMPKFMI_00919 5e-62 Z012_07300 O Glutaredoxin-related protein
HGMPKFMI_00920 2.1e-227 yttB EGP Major facilitator Superfamily
HGMPKFMI_00921 1.1e-36 XK27_04775 P Hemerythrin HHE cation binding domain protein
HGMPKFMI_00922 9.4e-33 S Iron-sulfur cluster assembly protein
HGMPKFMI_00923 8e-142 nrdG 1.97.1.4 O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HGMPKFMI_00924 0.0 nrdD 1.1.98.6 F Ribonucleoside-triphosphate reductase
HGMPKFMI_00925 7.6e-249 yxbA 6.3.1.12 S ATP-grasp enzyme
HGMPKFMI_00926 0.0 asnB 6.3.5.4 E Asparagine synthase
HGMPKFMI_00927 2e-274 S Calcineurin-like phosphoesterase
HGMPKFMI_00928 6.6e-84
HGMPKFMI_00930 1.8e-267 oppA E ABC transporter, substratebinding protein
HGMPKFMI_00931 1.1e-147 phnE 3.6.1.63 P Binding-protein-dependent transport system inner membrane component
HGMPKFMI_00932 2.6e-125 phnE 3.6.1.63 P Binding-protein-dependent transport system inner membrane component
HGMPKFMI_00933 3.3e-138 phnC 3.6.3.28 P Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HGMPKFMI_00934 4.3e-156 phnD P Phosphonate ABC transporter
HGMPKFMI_00935 2.5e-83 uspA T universal stress protein
HGMPKFMI_00936 1.7e-148 ptp3 3.1.3.48 T Tyrosine phosphatase family
HGMPKFMI_00937 5e-84 2.7.1.200, 2.7.1.202, 2.7.1.204 G Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HGMPKFMI_00938 3e-89 ntd 2.4.2.6 F Nucleoside
HGMPKFMI_00939 1.2e-221 nagA 3.5.1.25 G Belongs to the metallo-dependent hydrolases superfamily. NagA family
HGMPKFMI_00940 0.0 G Belongs to the glycosyl hydrolase 31 family
HGMPKFMI_00941 2.7e-144 malG P ABC transporter permease
HGMPKFMI_00942 2.2e-102 malF P Binding-protein-dependent transport system inner membrane component
HGMPKFMI_00943 3.9e-85 dexB 3.2.1.10, 3.2.1.70 GH13 G Alpha amylase, catalytic domain protein
HGMPKFMI_00944 1.4e-169 I alpha/beta hydrolase fold
HGMPKFMI_00945 4.5e-130 yibF S overlaps another CDS with the same product name
HGMPKFMI_00946 5.8e-184 yibE S overlaps another CDS with the same product name
HGMPKFMI_00947 6.7e-44
HGMPKFMI_00948 2.2e-204 ddl 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
HGMPKFMI_00949 1.5e-199 S Cysteine-rich secretory protein family
HGMPKFMI_00950 2.7e-117 flpA 4.1.99.16, 4.2.3.22, 4.2.3.75 K helix_turn_helix, cAMP Regulatory protein
HGMPKFMI_00951 1.2e-144
HGMPKFMI_00952 3.4e-126 luxT K Bacterial regulatory proteins, tetR family
HGMPKFMI_00953 4.3e-186 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HGMPKFMI_00954 2.8e-125 S Alpha/beta hydrolase family
HGMPKFMI_00955 2.5e-160 epsV 2.7.8.12 S glycosyl transferase family 2
HGMPKFMI_00956 1.8e-162 ypuA S Protein of unknown function (DUF1002)
HGMPKFMI_00957 1.5e-127 rnhA 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HGMPKFMI_00958 5.1e-181 S Alpha/beta hydrolase of unknown function (DUF915)
HGMPKFMI_00959 5.5e-283 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HGMPKFMI_00960 6.1e-82
HGMPKFMI_00961 1.9e-132 cobB K SIR2 family
HGMPKFMI_00962 3.7e-66 yeaO S Protein of unknown function, DUF488
HGMPKFMI_00963 9.4e-123 mpg 3.2.2.21 L Belongs to the DNA glycosylase MPG family
HGMPKFMI_00964 2.3e-274 glnP P ABC transporter permease
HGMPKFMI_00965 3.5e-140 glnQ E ABC transporter, ATP-binding protein
HGMPKFMI_00966 5e-114 CBM50 M NlpC P60 family protein
HGMPKFMI_00967 4.5e-174 L HNH nucleases
HGMPKFMI_00968 2.8e-16
HGMPKFMI_00969 5e-207 ybiR P Citrate transporter
HGMPKFMI_00970 1.6e-94 lemA S LemA family
HGMPKFMI_00971 4.4e-150 htpX O Belongs to the peptidase M48B family
HGMPKFMI_00972 1.2e-152 mutR K Helix-turn-helix XRE-family like proteins
HGMPKFMI_00973 1.3e-221 S ATP diphosphatase activity
HGMPKFMI_00975 1.1e-136 S ABC-2 family transporter protein
HGMPKFMI_00976 1.6e-108 S ABC-2 family transporter protein
HGMPKFMI_00977 9.5e-172 natA1 S ABC transporter
HGMPKFMI_00978 1e-151 K helix_turn_helix, arabinose operon control protein
HGMPKFMI_00979 1.1e-270 emrY EGP Major facilitator Superfamily
HGMPKFMI_00980 1.6e-252 cbiO1 S ABC transporter, ATP-binding protein
HGMPKFMI_00981 3.2e-113 P Cobalt transport protein
HGMPKFMI_00982 1.8e-18 L transposase and inactivated derivatives, IS30 family
HGMPKFMI_00983 1.3e-36 L transposase and inactivated derivatives, IS30 family
HGMPKFMI_00984 2.7e-61 pdxH S Pyridoxamine 5'-phosphate oxidase
HGMPKFMI_00989 2.8e-82 rlmH 2.1.1.177 J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HGMPKFMI_00990 7.2e-162 htrA 3.4.21.107 O serine protease
HGMPKFMI_00991 8.8e-150 vicX 3.1.26.11 S domain protein
HGMPKFMI_00992 1.5e-141 yycI S YycH protein
HGMPKFMI_00993 5e-242 yycH S YycH protein
HGMPKFMI_00994 0.0 vicK 2.7.13.3 T Histidine kinase
HGMPKFMI_00995 7.5e-132 K response regulator
HGMPKFMI_00997 7.2e-149 arbV 2.3.1.51 I Acyl-transferase
HGMPKFMI_00998 3.2e-155 arbx M Glycosyl transferase family 8
HGMPKFMI_00999 2.9e-98 arbY M Glycosyl transferase family 8
HGMPKFMI_01000 1.2e-165 arbZ I Phosphate acyltransferases
HGMPKFMI_01001 0.0 aroE 1.1.1.25, 1.1.1.282, 1.3.5.4 C FAD binding domain
HGMPKFMI_01002 1.9e-172 K Transcriptional regulator, LysR family
HGMPKFMI_01003 1.6e-85 ydiN C succinate dehydrogenase
HGMPKFMI_01004 7.3e-53 ydiN EGP Major Facilitator Superfamily
HGMPKFMI_01005 2.2e-96 S Membrane
HGMPKFMI_01006 4.5e-222 naiP EGP Major facilitator Superfamily
HGMPKFMI_01007 2.4e-167 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
HGMPKFMI_01008 1.6e-171 glk 2.7.1.2 G Glucokinase
HGMPKFMI_01010 2e-216 2.1.1.14 E methionine synthase, vitamin-B12 independent
HGMPKFMI_01011 2.6e-166 cpsY K Transcriptional regulator, LysR family
HGMPKFMI_01012 1.2e-129
HGMPKFMI_01013 0.0 mutS2 L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
HGMPKFMI_01014 5.3e-284 V ABC-type multidrug transport system, ATPase and permease components
HGMPKFMI_01015 5.2e-287 V ABC-type multidrug transport system, ATPase and permease components
HGMPKFMI_01016 3.4e-14 mmgC 1.3.8.1 I Acyl-CoA dehydrogenase, C-terminal domain
HGMPKFMI_01017 3e-41 L Transposase and inactivated derivatives, IS30 family
HGMPKFMI_01018 9.5e-132 L Transposase and inactivated derivatives, IS30 family
HGMPKFMI_01020 3.5e-31 bgl 3.2.1.21, 3.2.1.86 GT1 G beta-glucosidase activity
HGMPKFMI_01021 2e-193 manA 5.3.1.8 G mannose-6-phosphate isomerase
HGMPKFMI_01022 3.7e-28 scrK 2.7.1.2, 2.7.1.4 GK ROK family
HGMPKFMI_01024 3.5e-18 yliE T EAL domain
HGMPKFMI_01025 6e-140
HGMPKFMI_01026 1.6e-07
HGMPKFMI_01027 3.9e-84 K DNA-templated transcription, initiation
HGMPKFMI_01029 4.2e-135 glpF U Belongs to the MIP aquaporin (TC 1.A.8) family
HGMPKFMI_01030 5.8e-163 gtfA 2.4.1.7 GH13 G Sucrose glucosyltransferase
HGMPKFMI_01031 0.0 S Bacterial membrane protein, YfhO
HGMPKFMI_01032 1.3e-179 yfdH GT2 M Glycosyltransferase like family 2
HGMPKFMI_01033 5.5e-92 racA K Domain of unknown function (DUF1836)
HGMPKFMI_01034 1.7e-145 yitS S EDD domain protein, DegV family
HGMPKFMI_01035 1.1e-103 T EAL domain
HGMPKFMI_01036 4.1e-104 3.1.1.5 E GDSL-like Lipase/Acylhydrolase
HGMPKFMI_01037 4.7e-125 gpmB G Phosphoglycerate mutase family
HGMPKFMI_01038 8.1e-13
HGMPKFMI_01039 1.1e-119
HGMPKFMI_01040 1.3e-42
HGMPKFMI_01041 1.2e-89 S biotin transmembrane transporter activity
HGMPKFMI_01042 1.6e-53 C Coenzyme F420-dependent N5N10-methylene tetrahydromethanopterin reductase
HGMPKFMI_01043 2.6e-43 C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HGMPKFMI_01044 2.9e-182 gpsA 1.1.1.94 I Rossmann-like domain
HGMPKFMI_01045 3e-57 K sequence-specific DNA binding
HGMPKFMI_01046 2.2e-85
HGMPKFMI_01047 1.4e-70 F DNA/RNA non-specific endonuclease
HGMPKFMI_01049 8.1e-176 brpA K Cell envelope-like function transcriptional attenuator common domain protein
HGMPKFMI_01050 8.4e-66 S Core-2/I-Branching enzyme
HGMPKFMI_01051 3.6e-76 S Core-2/I-Branching enzyme
HGMPKFMI_01052 6.5e-119 rfbP 2.7.8.6 M Bacterial sugar transferase
HGMPKFMI_01053 2.2e-150 cps1D M Domain of unknown function (DUF4422)
HGMPKFMI_01054 8.6e-220 glf 5.4.99.9 M UDP-galactopyranose mutase
HGMPKFMI_01055 2.4e-109 cps1C S Membrane protein involved in the export of O-antigen and teichoic acid
HGMPKFMI_01056 2.3e-87 cps1C S Membrane protein involved in the export of O-antigen and teichoic acid
HGMPKFMI_01057 9.8e-16 L Transposase
HGMPKFMI_01058 1.2e-120 S Membrane protein involved in the export of O-antigen and teichoic acid
HGMPKFMI_01059 6.1e-28 L transposase activity
HGMPKFMI_01060 2.1e-10
HGMPKFMI_01061 2.9e-55 K Bacterial regulatory proteins, tetR family
HGMPKFMI_01062 2.9e-198 rfbB 4.2.1.46 M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
HGMPKFMI_01064 2.8e-18 higA K Helix-turn-helix XRE-family like proteins
HGMPKFMI_01065 3.1e-77 msrB 1.8.4.11, 1.8.4.12 O peptide methionine sulfoxide reductase
HGMPKFMI_01066 7.1e-96 S ABC transporter, ATP-binding protein
HGMPKFMI_01067 1.1e-154 XK27_00670 S ABC transporter
HGMPKFMI_01069 4.9e-27
HGMPKFMI_01070 1.5e-29 L Transposase
HGMPKFMI_01071 6.1e-93 L the current gene model (or a revised gene model) may contain a frame shift
HGMPKFMI_01072 3e-11 N phage tail tape measure protein
HGMPKFMI_01073 3.2e-98 yvqK 1.2.1.88, 1.5.5.2, 2.5.1.17 S cob(I)alamin adenosyltransferase
HGMPKFMI_01074 4.7e-94 S ECF transporter, substrate-specific component
HGMPKFMI_01075 3.2e-14 S Domain of unknown function (DUF4430)
HGMPKFMI_01076 0.0 rtpR 1.1.98.6, 1.17.4.1, 1.17.4.2 F ribonucleoside-triphosphate reductase activity
HGMPKFMI_01077 6.7e-164 yvgN C Aldo keto reductase
HGMPKFMI_01078 4.2e-172 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
HGMPKFMI_01079 2e-80
HGMPKFMI_01080 1e-161 xth 3.1.11.2 L exodeoxyribonuclease III
HGMPKFMI_01081 1.4e-59 S glycolate biosynthetic process
HGMPKFMI_01082 3.9e-18 L haloacid dehalogenase-like hydrolase
HGMPKFMI_01083 3.4e-137 yjjG 3.1.3.102, 3.1.3.104, 3.1.3.5, 3.8.1.2 S Haloacid dehalogenase-like hydrolase
HGMPKFMI_01084 3.2e-186 dapF 5.1.1.7 E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HGMPKFMI_01085 6.1e-252 lysC 2.7.2.4 E Belongs to the aspartokinase family
HGMPKFMI_01086 1.7e-72 dapD 2.3.1.117, 2.3.1.89 E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
HGMPKFMI_01087 2e-219 hipO 3.5.1.47 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
HGMPKFMI_01088 4.7e-171 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HGMPKFMI_01089 3.9e-142 dapB 1.17.1.8 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
HGMPKFMI_01090 2.8e-221 patA 2.6.1.1 E Aminotransferase
HGMPKFMI_01091 1.1e-109 ppiB 5.2.1.8 G PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HGMPKFMI_01092 3e-18 L Transposase and inactivated derivatives, IS30 family
HGMPKFMI_01093 1.7e-130 yfeJ 6.3.5.2 F glutamine amidotransferase
HGMPKFMI_01094 8.6e-95 2.4.2.6 F Nucleoside 2-deoxyribosyltransferase
HGMPKFMI_01095 1.4e-156 hipB K Helix-turn-helix
HGMPKFMI_01096 8.5e-153 I alpha/beta hydrolase fold
HGMPKFMI_01097 4.4e-106 yjbF S SNARE associated Golgi protein
HGMPKFMI_01098 6.1e-93 J Acetyltransferase (GNAT) domain
HGMPKFMI_01099 5.9e-236 serS 6.1.1.11 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HGMPKFMI_01100 6.5e-99 K Sigma-70 region 2
HGMPKFMI_01101 2.7e-152 S Protein of unknown function (DUF3298)
HGMPKFMI_01102 0.0 lacS G Transporter
HGMPKFMI_01103 0.0 lacL 3.2.1.23 G Belongs to the glycosyl hydrolase 2 family
HGMPKFMI_01104 6.6e-26 K purine nucleotide biosynthetic process
HGMPKFMI_01105 1.4e-107 galR K Transcriptional regulator
HGMPKFMI_01106 6e-188 ldhA 1.1.1.28 C Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HGMPKFMI_01107 9e-259 1.1.3.15 C FAD linked oxidases, C-terminal domain
HGMPKFMI_01108 4.2e-74 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins
HGMPKFMI_01109 4.7e-136 metQ_4 P Belongs to the nlpA lipoprotein family
HGMPKFMI_01110 4.2e-91 luxS 4.4.1.21 H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
HGMPKFMI_01112 6.7e-209 S amidohydrolase
HGMPKFMI_01113 2.1e-14 XK27_07210 6.1.1.6 S B3 4 domain
HGMPKFMI_01114 1.8e-230 E Arginine ornithine antiporter
HGMPKFMI_01131 7.8e-120 3.6.1.27 I Acid phosphatase homologues
HGMPKFMI_01132 1.5e-261 mdr EGP Sugar (and other) transporter
HGMPKFMI_01133 1.1e-217 metK 2.5.1.6 H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HGMPKFMI_01139 8.4e-216 EGP Major facilitator Superfamily
HGMPKFMI_01140 0.0 pepX 3.4.14.11 E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline
HGMPKFMI_01142 0.0 traI 5.99.1.2 L This gene contains a nucleotide ambiguity which may be the result of a sequencing error
HGMPKFMI_01143 6.2e-308 S SH3-like domain
HGMPKFMI_01144 2.1e-53
HGMPKFMI_01145 1.8e-37
HGMPKFMI_01146 2.9e-79
HGMPKFMI_01147 1e-213 EGP Major Facilitator Superfamily
HGMPKFMI_01148 4.8e-41 XK27_05520 S Uncharacterized protein conserved in bacteria (DUF2087)
HGMPKFMI_01149 1.1e-83 purE 5.4.99.18 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HGMPKFMI_01150 2.5e-211 purK 6.3.4.18 F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HGMPKFMI_01151 4.4e-252 purB 4.3.2.2 F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HGMPKFMI_01152 1.6e-134 purC 4.1.1.21, 4.3.2.2, 6.3.2.6 F Belongs to the SAICAR synthetase family
HGMPKFMI_01153 2.8e-38 purS 6.3.2.6, 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HGMPKFMI_01154 5.2e-127 purQ 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HGMPKFMI_01155 0.0 purL 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HGMPKFMI_01156 6.6e-284 purF 2.4.2.14 F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HGMPKFMI_01157 4.6e-199 purM 6.3.3.1, 6.3.4.13 F Phosphoribosylformylglycinamidine cyclo-ligase
HGMPKFMI_01158 6.5e-110 purN 2.1.2.2 F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HGMPKFMI_01159 4.3e-294 purH 2.1.2.3, 3.5.4.10 F Bifunctional purine biosynthesis protein PurH
HGMPKFMI_01160 5.9e-241 purD 6.3.4.13 F Belongs to the GARS family
HGMPKFMI_01161 9.6e-56 livF E ABC transporter
HGMPKFMI_01162 3.6e-91 metB 2.5.1.48, 4.4.1.8 E Cys/Met metabolism PLP-dependent enzyme
HGMPKFMI_01163 1.3e-65 arsC 1.20.4.1 P Belongs to the ArsC family
HGMPKFMI_01164 9.9e-49 rplU J This protein binds to 23S rRNA in the presence of protein L20
HGMPKFMI_01165 1.6e-48 rpmA J Belongs to the bacterial ribosomal protein bL27 family
HGMPKFMI_01166 1e-196 pepP 3.4.11.9, 3.4.13.9 E Creatinase/Prolidase N-terminal domain
HGMPKFMI_01167 2e-100 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HGMPKFMI_01168 8.1e-73 yqhY S Asp23 family, cell envelope-related function
HGMPKFMI_01169 1.8e-66 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HGMPKFMI_01170 4.3e-155 folD 1.5.1.5, 3.5.4.9 F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HGMPKFMI_01171 8e-252 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HGMPKFMI_01172 1.7e-32 xseB 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HGMPKFMI_01173 5.4e-161 ispA 2.5.1.1, 2.5.1.10, 2.5.1.29, 2.5.1.90 H Belongs to the FPP GGPP synthase family
HGMPKFMI_01174 7.8e-154 rrmJ 2.1.1.226, 2.1.1.227 J Ribosomal RNA large subunit methyltransferase J
HGMPKFMI_01175 7e-306 recN L May be involved in recombinational repair of damaged DNA
HGMPKFMI_01176 3.5e-46 oppA E transmembrane transport
HGMPKFMI_01177 2.9e-14 oppA E ABC transporter, substratebinding protein
HGMPKFMI_01178 3.2e-33 oppA E transmembrane transport
HGMPKFMI_01179 2.6e-49
HGMPKFMI_01180 1.1e-110 gmk 2.7.4.8, 4.1.1.23 F Essential for recycling GMP and indirectly, cGMP
HGMPKFMI_01181 2.4e-33 rpoZ 2.7.7.6 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
HGMPKFMI_01182 0.0 priA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HGMPKFMI_01183 6.7e-173 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HGMPKFMI_01184 4.1e-245 sun 2.1.1.176 J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HGMPKFMI_01185 4.3e-138 stp 3.1.3.16 T phosphatase
HGMPKFMI_01186 0.0 KLT serine threonine protein kinase
HGMPKFMI_01187 1.7e-165 rsgA 3.1.3.100 S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
HGMPKFMI_01188 4.7e-128 thiN 2.7.6.2 H thiamine pyrophosphokinase
HGMPKFMI_01190 1.8e-30 D nuclear chromosome segregation
HGMPKFMI_01193 6.5e-282 V ABC transporter transmembrane region
HGMPKFMI_01194 3.2e-26 rpmB J Belongs to the bacterial ribosomal protein bL28 family
HGMPKFMI_01195 8.8e-57 asp S Asp23 family, cell envelope-related function
HGMPKFMI_01196 1.6e-278 yloV S DAK2 domain fusion protein YloV
HGMPKFMI_01197 0.0 recG 3.6.4.12 L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HGMPKFMI_01198 7.5e-183 plsX 2.3.1.15 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
HGMPKFMI_01199 5.7e-36 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
HGMPKFMI_01200 3.7e-190 oppD P Belongs to the ABC transporter superfamily
HGMPKFMI_01201 2.4e-178 oppF P Belongs to the ABC transporter superfamily
HGMPKFMI_01202 7.7e-177 oppB P ABC transporter permease
HGMPKFMI_01203 1.3e-157 oppC P Binding-protein-dependent transport system inner membrane component
HGMPKFMI_01204 0.0 oppA1 E ABC transporter substrate-binding protein
HGMPKFMI_01205 0.0 oppA E ABC transporter substrate-binding protein
HGMPKFMI_01206 3.1e-127 rnc 3.1.26.3 J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
HGMPKFMI_01207 0.0 smc D Required for chromosome condensation and partitioning
HGMPKFMI_01208 3.4e-154 ftsY U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HGMPKFMI_01209 1.5e-25 pipD E Dipeptidase
HGMPKFMI_01210 8.6e-54 ylxM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HGMPKFMI_01211 1.2e-245 ffh 3.6.5.4 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HGMPKFMI_01212 3.8e-44 rpsP J Belongs to the bacterial ribosomal protein bS16 family
HGMPKFMI_01213 1.8e-92 rimM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HGMPKFMI_01214 5.4e-138 trmD 2.1.1.228, 4.6.1.12 J Belongs to the RNA methyltransferase TrmD family
HGMPKFMI_01215 1.8e-09 CP_1020 S Psort location Cytoplasmic, score 8.87
HGMPKFMI_01216 3.9e-09 snf 2.7.11.1 KL domain protein
HGMPKFMI_01217 0.0 snf 2.7.11.1 KL domain protein
HGMPKFMI_01218 5.5e-56 rplS J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
HGMPKFMI_01219 0.0 XK27_00340 3.1.3.5 F Belongs to the 5'-nucleotidase family
HGMPKFMI_01220 0.0 S TerB-C domain
HGMPKFMI_01221 5.2e-248 P P-loop Domain of unknown function (DUF2791)
HGMPKFMI_01222 0.0 lhr L DEAD DEAH box helicase
HGMPKFMI_01223 3.4e-97
HGMPKFMI_01224 9.5e-145 glnH ET ABC transporter substrate-binding protein
HGMPKFMI_01225 6e-149 glcU U ribose uptake protein RbsU
HGMPKFMI_01226 3.5e-114 lexA 3.4.21.88 K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HGMPKFMI_01227 1.5e-33 ynzC S UPF0291 protein
HGMPKFMI_01228 2.3e-31 yneF S Uncharacterised protein family (UPF0154)
HGMPKFMI_01229 0.0 mdlA V ABC transporter
HGMPKFMI_01230 0.0 mdlB V ABC transporter
HGMPKFMI_01231 2.6e-71 pheB 5.4.99.5 S Belongs to the UPF0735 family
HGMPKFMI_01232 1e-212 hom 1.1.1.3 E homoserine dehydrogenase
HGMPKFMI_01233 1.3e-251 yclM 2.7.2.4 E Belongs to the aspartokinase family
HGMPKFMI_01234 4.8e-182 asd 1.2.1.11 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HGMPKFMI_01235 1.4e-115 plsC 2.3.1.51 I Acyltransferase
HGMPKFMI_01236 3.2e-189 yabB 2.1.1.223 L Methyltransferase small domain
HGMPKFMI_01237 1.1e-136 rpsB J Belongs to the universal ribosomal protein uS2 family
HGMPKFMI_01238 5.4e-184 tsf J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HGMPKFMI_01239 4.9e-131 pyrH 2.7.4.22 F Catalyzes the reversible phosphorylation of UMP to UDP
HGMPKFMI_01240 2.9e-91 frr J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
HGMPKFMI_01241 7.6e-124 uppS 2.5.1.31 H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HGMPKFMI_01242 1.1e-144 cdsA 2.7.7.41 S Belongs to the CDS family
HGMPKFMI_01243 2.3e-229 rseP 3.4.21.107, 3.4.21.116 M zinc metalloprotease
HGMPKFMI_01244 0.0 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
HGMPKFMI_01245 0.0 polC 2.7.7.7 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HGMPKFMI_01246 1.9e-83 rimP J Required for maturation of 30S ribosomal subunits
HGMPKFMI_01247 6.8e-194 nusA K Participates in both transcription termination and antitermination
HGMPKFMI_01248 4.3e-43 ylxR K Protein of unknown function (DUF448)
HGMPKFMI_01249 4.8e-42 rplGA J ribosomal protein
HGMPKFMI_01250 0.0 infB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HGMPKFMI_01251 5.5e-59 rbfA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HGMPKFMI_01252 1.8e-167 truB 5.4.99.25 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HGMPKFMI_01253 3.2e-53 cysE 2.3.1.30 E Bacterial transferase hexapeptide (six repeats)
HGMPKFMI_01254 7e-220 metC 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
HGMPKFMI_01255 3.9e-170 mccA 2.5.1.134, 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
HGMPKFMI_01256 4.3e-88 luxS 4.4.1.21 H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
HGMPKFMI_01257 0.0 metE 2.1.1.14 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HGMPKFMI_01258 5.4e-26 metF 1.5.1.20 C Methylenetetrahydrofolate reductase
HGMPKFMI_01259 1.1e-39 M Glycosyltransferase like family 2
HGMPKFMI_01260 7.6e-129 L DDE superfamily endonuclease
HGMPKFMI_01261 5.4e-48 M Glycosyltransferase, group 2 family protein
HGMPKFMI_01262 3.2e-248 nhaC C Na H antiporter NhaC
HGMPKFMI_01263 1.7e-54 L Putative transposase DNA-binding domain
HGMPKFMI_01269 1.1e-185 asnB 6.3.5.4 E Aluminium induced protein
HGMPKFMI_01270 7.4e-58 asnB 6.3.5.4 E Aluminium induced protein
HGMPKFMI_01271 1.2e-160 spoU 2.1.1.185 J Methyltransferase
HGMPKFMI_01275 8.1e-54 ribD 1.1.1.193, 3.5.4.26 H MafB19-like deaminase
HGMPKFMI_01276 1.7e-12 ribE 2.5.1.9, 3.5.4.25, 4.1.99.12 H Riboflavin synthase
HGMPKFMI_01277 1.3e-199 ribBA 3.5.4.25, 4.1.99.12 H Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate
HGMPKFMI_01278 1.4e-78 ribH 2.5.1.78 H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
HGMPKFMI_01279 1.1e-12
HGMPKFMI_01280 1.6e-232 isp2 L Transposase
HGMPKFMI_01281 2.6e-37 P Sodium:sulfate symporter transmembrane region
HGMPKFMI_01282 2.1e-154 K LysR family
HGMPKFMI_01283 1.8e-74
HGMPKFMI_01284 5e-63 L Transposase
HGMPKFMI_01285 1e-240 pts13C G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HGMPKFMI_01286 7.4e-166 S Alpha/beta hydrolase of unknown function (DUF915)
HGMPKFMI_01287 4.4e-149 S Sucrose-6F-phosphate phosphohydrolase
HGMPKFMI_01288 7.7e-140 puuD S peptidase C26
HGMPKFMI_01289 1.2e-158 yicL EG EamA-like transporter family
HGMPKFMI_01290 5.7e-49 L Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed
HGMPKFMI_01291 1.1e-31 tnp2 L PFAM Transposase, IS204 IS1001 IS1096 IS1165
HGMPKFMI_01292 8.2e-25 L Transposase
HGMPKFMI_01293 2.8e-168 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
HGMPKFMI_01294 3.2e-95 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HGMPKFMI_01295 7.2e-183 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
HGMPKFMI_01296 3.2e-247 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
HGMPKFMI_01297 6.4e-212 carA 6.3.5.5 F Carbamoyl-phosphate synthetase glutamine chain
HGMPKFMI_01298 0.0 carB 6.3.5.5 F Carbamoyl-phosphate synthase
HGMPKFMI_01299 7.7e-31 brnQ U Component of the transport system for branched-chain amino acids
HGMPKFMI_01300 1.1e-22 brnQ U Component of the transport system for branched-chain amino acids
HGMPKFMI_01301 2.1e-128 5.99.1.2 T diguanylate cyclase
HGMPKFMI_01302 0.0 clpL O C-terminal, D2-small domain, of ClpB protein
HGMPKFMI_01303 1.5e-36
HGMPKFMI_01304 1.4e-129 cobQ S glutamine amidotransferase
HGMPKFMI_01305 2.8e-220 glpK 2.7.1.30 F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HGMPKFMI_01306 4e-144 ptp2 3.1.3.48 T Tyrosine phosphatase family
HGMPKFMI_01307 0.0 KLT serine threonine protein kinase
HGMPKFMI_01308 2.8e-288 V ABC-type multidrug transport system, ATPase and permease components
HGMPKFMI_01309 2e-146 ptp2 3.1.3.48 T Tyrosine phosphatase family
HGMPKFMI_01310 9.9e-91 ymdB S Macro domain protein
HGMPKFMI_01311 1.4e-34
HGMPKFMI_01312 1.7e-46 V RRXRR protein
HGMPKFMI_01313 3.5e-150
HGMPKFMI_01315 4.6e-263 fumC 4.2.1.2 C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
HGMPKFMI_01316 8.6e-257 P Sodium:sulfate symporter transmembrane region
HGMPKFMI_01317 2.4e-253 pipD M Peptidase family C69
HGMPKFMI_01318 1.8e-173 citR K Putative sugar-binding domain
HGMPKFMI_01319 6.3e-36 lysM M LysM domain
HGMPKFMI_01320 0.0 pepN 3.4.11.2 E aminopeptidase
HGMPKFMI_01321 1.1e-29 drgA C coenzyme F420-1:gamma-L-glutamate ligase activity
HGMPKFMI_01322 8.3e-08 1.13.11.79 C Nitroreductase family
HGMPKFMI_01323 1.7e-226 S Putative peptidoglycan binding domain
HGMPKFMI_01324 6e-117
HGMPKFMI_01325 6.4e-139 S Belongs to the UPF0246 family
HGMPKFMI_01326 2.5e-18 glcD2 1.1.3.15 C FAD linked oxidases, C-terminal domain
HGMPKFMI_01327 6.6e-59 glcD2 1.1.3.15 C FAD linked oxidases, C-terminal domain
HGMPKFMI_01329 6.1e-109
HGMPKFMI_01330 2.1e-117 V AAA domain, putative AbiEii toxin, Type IV TA system
HGMPKFMI_01331 6.7e-17
HGMPKFMI_01332 1.5e-274 pipD E Dipeptidase
HGMPKFMI_01333 1.5e-97 K WHG domain
HGMPKFMI_01334 3.8e-96 nqr 1.5.1.36 S NADPH-dependent FMN reductase
HGMPKFMI_01335 5e-96 azr 1.5.1.36 S NADPH-dependent FMN reductase
HGMPKFMI_01336 1.6e-143 3.1.3.48 T Tyrosine phosphatase family
HGMPKFMI_01337 6.8e-189 apbE 2.7.1.180 H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
HGMPKFMI_01338 2.4e-87 cvpA S Colicin V production protein
HGMPKFMI_01339 3.9e-298 L Putative transposase DNA-binding domain
HGMPKFMI_01340 1.2e-36 guaB2 L Resolvase, N terminal domain
HGMPKFMI_01341 7.4e-132 rsmG 2.1.1.170 J Specifically methylates the N7 position of a guanine in 16S rRNA
HGMPKFMI_01342 3.7e-143 noc K Belongs to the ParB family
HGMPKFMI_01343 2.6e-138 soj D Sporulation initiation inhibitor
HGMPKFMI_01344 7.8e-155 spo0J K Belongs to the ParB family
HGMPKFMI_01345 2.5e-45 yyzM S Bacterial protein of unknown function (DUF951)
HGMPKFMI_01346 6.1e-202 ychF J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
HGMPKFMI_01347 1.8e-136 XK27_01040 S Protein of unknown function (DUF1129)
HGMPKFMI_01348 9.6e-311 V ABC transporter, ATP-binding protein
HGMPKFMI_01349 0.0 ndvA V ABC transporter
HGMPKFMI_01350 1e-122 K response regulator
HGMPKFMI_01351 6.5e-221 hpk31 2.7.13.3 T His Kinase A (phospho-acceptor) domain
HGMPKFMI_01352 6.4e-298 murE 6.3.2.13, 6.3.2.7 M Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HGMPKFMI_01353 1.4e-144 racD 5.1.1.13 M Belongs to the aspartate glutamate racemases family
HGMPKFMI_01354 2.8e-134 fruR K DeoR C terminal sensor domain
HGMPKFMI_01355 4.5e-166 pfkB 2.7.1.11, 2.7.1.56 H Belongs to the carbohydrate kinase PfkB family. LacC subfamily
HGMPKFMI_01356 0.0 fruA 2.7.1.202, 2.7.1.204 GT Phosphotransferase System
HGMPKFMI_01357 1e-145 3.1.3.102, 3.1.3.104, 3.1.3.23 G Sucrose-6F-phosphate phosphohydrolase
HGMPKFMI_01358 1e-119 fhuC P ABC transporter
HGMPKFMI_01359 8e-135 znuB U ABC 3 transport family
HGMPKFMI_01360 4.1e-48 KT response to antibiotic
HGMPKFMI_01361 2.4e-99 lctO C L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases
HGMPKFMI_01362 0.0 pepF E oligoendopeptidase F
HGMPKFMI_01363 2.4e-250 L Putative transposase DNA-binding domain
HGMPKFMI_01364 1.1e-206 brpA K Cell envelope-like function transcriptional attenuator common domain protein
HGMPKFMI_01365 2.7e-16
HGMPKFMI_01366 9.5e-294 S ABC transporter, ATP-binding protein
HGMPKFMI_01367 7e-136 thrE S Putative threonine/serine exporter
HGMPKFMI_01368 2.3e-84 S Threonine/Serine exporter, ThrE
HGMPKFMI_01369 1.4e-68
HGMPKFMI_01370 2.2e-111
HGMPKFMI_01371 3.7e-290 S O-antigen ligase like membrane protein
HGMPKFMI_01372 7.2e-45
HGMPKFMI_01373 9.3e-95 gmk2 2.7.4.8 F Guanylate kinase homologues.
HGMPKFMI_01374 6.2e-82 M NlpC P60 family
HGMPKFMI_01375 1.2e-199 ldhA 1.1.1.28 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HGMPKFMI_01376 6.5e-76 M NlpC/P60 family
HGMPKFMI_01377 6.2e-108 M NlpC/P60 family
HGMPKFMI_01378 2.5e-66 M NlpC P60 family protein
HGMPKFMI_01379 6.3e-38 M NlpC P60 family protein
HGMPKFMI_01380 5e-94 M NlpC P60 family protein
HGMPKFMI_01381 1e-118 M NlpC P60 family protein
HGMPKFMI_01382 4.9e-227 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HGMPKFMI_01383 4.9e-177 brpA K Cell envelope-like function transcriptional attenuator common domain protein
HGMPKFMI_01384 1.9e-108 epsB M biosynthesis protein
HGMPKFMI_01385 2e-106 ywqD 2.7.10.1 D Capsular exopolysaccharide family
HGMPKFMI_01386 8.8e-147 ywqE 3.1.3.48 GM PHP domain protein
HGMPKFMI_01387 7.8e-123 rfbP M Bacterial sugar transferase
HGMPKFMI_01388 5.3e-174 M Glycosyl transferase 4-like
HGMPKFMI_01389 6.2e-37 epsH S Hexapeptide repeat of succinyl-transferase
HGMPKFMI_01390 8.7e-65 cps4G M Glycosyl transferases group 1
HGMPKFMI_01401 5.8e-137 metAA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to
HGMPKFMI_01404 5e-95 asnS 6.1.1.22 J Asparaginyl-tRNA synthetase
HGMPKFMI_01405 9.3e-72 maa 2.3.1.18, 2.3.1.79 S Maltose acetyltransferase
HGMPKFMI_01406 4.7e-48 S Alpha beta hydrolase
HGMPKFMI_01407 1.5e-160 xerD L Phage integrase, N-terminal SAM-like domain
HGMPKFMI_01408 2e-103 lepB 3.4.21.89 U Belongs to the peptidase S26 family
HGMPKFMI_01409 7.3e-23
HGMPKFMI_01410 4.3e-244 pepT 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
HGMPKFMI_01411 4.2e-152 yqfO 3.5.4.16 S Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HGMPKFMI_01412 1.8e-122 trmK 2.1.1.217 S SAM-dependent methyltransferase
HGMPKFMI_01413 9e-80 mutT 3.6.1.55 F NUDIX domain
HGMPKFMI_01414 3.6e-138 S Peptidase family M23
HGMPKFMI_01415 8.9e-26 ogt 2.1.1.63 L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HGMPKFMI_01416 7.7e-78 ogt 2.1.1.63 L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HGMPKFMI_01417 4.9e-29 adaA1 2.1.1.63, 3.2.2.21 K sequence-specific DNA binding
HGMPKFMI_01418 8.9e-179 1.3.5.4 C FAD binding domain
HGMPKFMI_01419 3.5e-65 1.3.5.4 C domain protein
HGMPKFMI_01420 5.8e-46 K Transcriptional regulator
HGMPKFMI_01423 1.7e-218 2.1.1.37 H C-5 cytosine-specific DNA methylase
HGMPKFMI_01424 5.2e-231 L NgoFVII restriction endonuclease
HGMPKFMI_01425 0.0 Z012_07420 3.1.21.5 V Z1 domain
HGMPKFMI_01426 5.7e-47 vsr L DNA mismatch endonuclease Vsr
HGMPKFMI_01428 5.4e-144 V HNH endonuclease
HGMPKFMI_01429 4.5e-111 prrC S AAA domain
HGMPKFMI_01430 8.2e-31 L Transposase
HGMPKFMI_01431 1.5e-65 L Transposase
HGMPKFMI_01432 7.6e-201 N Uncharacterized conserved protein (DUF2075)
HGMPKFMI_01433 3.8e-41 N Uncharacterized conserved protein (DUF2075)
HGMPKFMI_01434 8.4e-207 S Protein of unknown function DUF262
HGMPKFMI_01435 3.4e-25
HGMPKFMI_01436 4.6e-200 2.1.1.72 V type I restriction-modification system
HGMPKFMI_01437 5e-35 mdt(A) EGP Major facilitator Superfamily
HGMPKFMI_01438 0.0 copB 3.6.3.4 P P-type ATPase
HGMPKFMI_01439 1.7e-41 celA 3.2.1.86 GT1 G beta-glucosidase activity
HGMPKFMI_01440 2.8e-37 celA 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
HGMPKFMI_01441 1.4e-204 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HGMPKFMI_01442 5.3e-201 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
HGMPKFMI_01443 1.7e-199 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
HGMPKFMI_01444 0.0 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
HGMPKFMI_01445 0.0 glyS 6.1.1.14 J Glycyl-tRNA synthetase beta subunit
HGMPKFMI_01446 1.3e-178 glyQ 6.1.1.14 J glycyl-tRNA synthetase alpha subunit
HGMPKFMI_01447 3.4e-135 recO L Involved in DNA repair and RecF pathway recombination
HGMPKFMI_01448 2.8e-168 era S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HGMPKFMI_01449 2.9e-75 cdd 3.5.4.5 F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
HGMPKFMI_01450 2.3e-98 ybeY 2.6.99.2, 3.5.4.5 S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HGMPKFMI_01451 6.3e-171 phoH T phosphate starvation-inducible protein PhoH
HGMPKFMI_01452 2e-22 rpsU J Belongs to the bacterial ribosomal protein bS21 family
HGMPKFMI_01453 8.2e-154 yqfL 2.7.11.33, 2.7.4.28 F Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation
HGMPKFMI_01455 2.2e-162 yitT S Uncharacterised 5xTM membrane BCR, YitT family COG1284
HGMPKFMI_01456 6.3e-56 L An automated process has identified a potential problem with this gene model
HGMPKFMI_01458 1.2e-07 secY2 U SecY translocase
HGMPKFMI_01459 3.6e-224 patA 2.6.1.1, 2.6.1.57 E Aminotransferase
HGMPKFMI_01460 2.9e-251 lysA 4.1.1.19, 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
HGMPKFMI_01463 1.8e-175 lacX 5.1.3.3 G Aldose 1-epimerase
HGMPKFMI_01464 1.2e-242 hslU O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HGMPKFMI_01465 4e-90 hslV 3.4.25.2 O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HGMPKFMI_01466 1.8e-164 xerC D Phage integrase, N-terminal SAM-like domain
HGMPKFMI_01467 4e-248 trmFO 2.1.1.74 J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HGMPKFMI_01468 0.0 topA 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HGMPKFMI_01469 3.7e-151 dprA LU DNA protecting protein DprA
HGMPKFMI_01470 7.4e-138 rnhB 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HGMPKFMI_01471 7.4e-163 ylqF S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HGMPKFMI_01472 5.5e-36 yozE S Belongs to the UPF0346 family
HGMPKFMI_01473 3.3e-155 DegV S Uncharacterised protein, DegV family COG1307
HGMPKFMI_01474 1.6e-117 hlyIII S protein, hemolysin III
HGMPKFMI_01475 4.1e-220 cca 2.7.7.19, 2.7.7.72 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HGMPKFMI_01476 4.3e-169 ypjC S Uncharacterised 5xTM membrane BCR, YitT family COG1284
HGMPKFMI_01477 2.9e-26 yliE T Putative diguanylate phosphodiesterase
HGMPKFMI_01478 5.2e-08 yliE T Putative diguanylate phosphodiesterase
HGMPKFMI_01480 0.0 XK27_10035 V ABC transporter
HGMPKFMI_01481 4.1e-309 yfiB1 V ABC transporter, ATP-binding protein
HGMPKFMI_01482 3.7e-165 lysR7 K LysR substrate binding domain
HGMPKFMI_01483 1.2e-157
HGMPKFMI_01484 1.6e-100 3.6.1.27 I Acid phosphatase homologues
HGMPKFMI_01485 9.8e-152 yitS S Uncharacterised protein, DegV family COG1307
HGMPKFMI_01486 1.7e-243 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
HGMPKFMI_01487 1.8e-53 S Protein of unknown function (DUF2752)
HGMPKFMI_01488 4.2e-181 yjgN S Bacterial protein of unknown function (DUF898)
HGMPKFMI_01489 1.6e-103 S Protein of unknown function (DUF4230)
HGMPKFMI_01490 2.8e-134 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
HGMPKFMI_01491 6.1e-261 glnPH2 P ABC transporter permease
HGMPKFMI_01492 1.7e-159 lysR5 K LysR substrate binding domain
HGMPKFMI_01493 0.0 3.6.3.2, 3.6.3.6 P Cation transporter/ATPase, N-terminus
HGMPKFMI_01494 6e-28 brpA K Cell envelope-like function transcriptional attenuator common domain protein
HGMPKFMI_01495 8.6e-68 brpA K Cell envelope-like function transcriptional attenuator common domain protein
HGMPKFMI_01496 8e-15 brpA K Cell envelope-like function transcriptional attenuator common domain protein
HGMPKFMI_01497 4.1e-185 S AI-2E family transporter
HGMPKFMI_01498 5.3e-200 ilvE 2.6.1.42 E Branched-chain amino acid aminotransferase
HGMPKFMI_01499 6.5e-154 czcD P cation diffusion facilitator family transporter
HGMPKFMI_01500 2.5e-49 K DNA-binding transcription factor activity
HGMPKFMI_01501 9.1e-95 apt 2.4.2.22, 2.4.2.7 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HGMPKFMI_01502 0.0 recJ L Single-stranded-DNA-specific exonuclease RecJ
HGMPKFMI_01503 2.8e-123 srtA 3.4.22.70 M sortase family
HGMPKFMI_01504 0.0 lepA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
HGMPKFMI_01505 6.8e-172 dnaJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
HGMPKFMI_01506 0.0 dnaK O Heat shock 70 kDa protein
HGMPKFMI_01507 5.7e-80 grpE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HGMPKFMI_01508 1.9e-189 hrcA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
HGMPKFMI_01509 9e-178 ribF 2.7.1.26, 2.7.7.2 H Belongs to the ribF family
HGMPKFMI_01510 9.9e-100 sip L Belongs to the 'phage' integrase family
HGMPKFMI_01511 3.6e-40 L DDE superfamily endonuclease
HGMPKFMI_01516 3.4e-26 L DDE superfamily endonuclease
HGMPKFMI_01518 1.7e-69 E Methionine synthase
HGMPKFMI_01519 7.8e-227 EK Aminotransferase, class I
HGMPKFMI_01520 2.8e-168 K LysR substrate binding domain
HGMPKFMI_01521 0.0 argS 6.1.1.19 J Arginyl-tRNA synthetase
HGMPKFMI_01522 1e-76 argR K Regulates arginine biosynthesis genes
HGMPKFMI_01523 3.1e-223 coaBC 4.1.1.36, 6.3.2.5 H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HGMPKFMI_01524 3.1e-77 S Amidohydrolase
HGMPKFMI_01525 1.6e-108 S Amidohydrolase
HGMPKFMI_01526 8.5e-176 gyaR 1.1.1.26, 2.7.1.165 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HGMPKFMI_01527 0.0 recQ 3.6.4.12 L ATP-dependent DNA helicase RecQ
HGMPKFMI_01528 3.2e-183 iunH 3.2.2.1 F inosine-uridine preferring nucleoside hydrolase
HGMPKFMI_01529 0.0 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
HGMPKFMI_01530 8.1e-235 obg S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HGMPKFMI_01531 0.0 oatA I Acyltransferase
HGMPKFMI_01532 3.7e-176 rnz 3.1.26.11 J Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
HGMPKFMI_01533 4.5e-138 XK27_05435 1.1.1.100 S Belongs to the short-chain dehydrogenases reductases (SDR) family
HGMPKFMI_01534 1e-27 rpmF J Belongs to the bacterial ribosomal protein bL32 family
HGMPKFMI_01535 6.9e-308 cpdB 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
HGMPKFMI_01536 0.0 L SNF2 family N-terminal domain
HGMPKFMI_01537 4.9e-34
HGMPKFMI_01539 3.2e-98 ywlG S Belongs to the UPF0340 family
HGMPKFMI_01540 1.9e-15 gmuR K UTRA
HGMPKFMI_01541 4.4e-55 gmuR K UbiC transcription regulator-associated domain protein
HGMPKFMI_01542 4.8e-61 proB 2.7.2.11 F Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HGMPKFMI_01543 4.3e-29 S Protein of unknown function (DUF2929)
HGMPKFMI_01544 0.0 dnaE 2.7.7.7 L DNA polymerase
HGMPKFMI_01545 2e-180 pfkA 2.7.1.11, 2.7.1.90 F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
HGMPKFMI_01546 0.0 pyk 2.7.1.40, 2.7.7.4 G Belongs to the pyruvate kinase family
HGMPKFMI_01547 5.9e-39 ssuB P anion transmembrane transporter activity
HGMPKFMI_01549 4e-59 I Acyltransferase family
HGMPKFMI_01550 4e-164 cvfB S S1 domain
HGMPKFMI_01551 5.4e-164 xerD D recombinase XerD
HGMPKFMI_01552 8.9e-62 ribT K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HGMPKFMI_01553 6e-129 scpA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HGMPKFMI_01554 5.9e-106 scpB D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HGMPKFMI_01555 9.1e-130 rluB 5.4.99.19, 5.4.99.21, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
HGMPKFMI_01556 3.9e-117 U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HGMPKFMI_01558 3e-108 cmk 1.17.7.4, 2.5.1.19, 2.7.1.26, 2.7.4.25, 2.7.7.2, 6.3.2.1 F Belongs to the cytidylate kinase family. Type 1 subfamily
HGMPKFMI_01559 8.4e-213 rpsA 1.17.7.4 J Ribosomal protein S1
HGMPKFMI_01560 7.4e-247 der 1.1.1.399, 1.1.1.95 S GTPase that plays an essential role in the late steps of ribosome biogenesis
HGMPKFMI_01561 2.6e-40 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
HGMPKFMI_01562 3.9e-229 S Tetratricopeptide repeat protein
HGMPKFMI_01563 0.0 S Bacterial membrane protein YfhO
HGMPKFMI_01564 4.7e-171 K LysR substrate binding domain
HGMPKFMI_01565 7.4e-09 K Transcriptional regulator, LysR family
HGMPKFMI_01566 4.4e-115 K DNA-binding transcription factor activity
HGMPKFMI_01567 3.4e-26
HGMPKFMI_01568 6.8e-09
HGMPKFMI_01569 0.0 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HGMPKFMI_01570 7e-71
HGMPKFMI_01572 9.2e-183 argH 2.3.1.1, 4.3.2.1 E argininosuccinate lyase
HGMPKFMI_01574 3.8e-18
HGMPKFMI_01576 6.2e-12 1.3.5.4 S FMN binding
HGMPKFMI_01577 7.8e-114 2.7.6.5 T Region found in RelA / SpoT proteins
HGMPKFMI_01578 2.2e-117 K response regulator
HGMPKFMI_01579 5.7e-228 sptS 2.7.13.3 T Histidine kinase
HGMPKFMI_01580 8.7e-18 cas9 L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
HGMPKFMI_01581 0.0 cas9 L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
HGMPKFMI_01582 2e-129 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HGMPKFMI_01583 4.6e-38 cas2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HGMPKFMI_01584 4.6e-51 S CRISPR-associated protein (Cas_Csn2)
HGMPKFMI_01585 1.2e-194 atoB 1.1.1.88, 2.3.1.9 I Belongs to the thiolase family
HGMPKFMI_01586 3.4e-217 mvaA 1.1.1.34, 1.1.1.88, 2.3.1.9 C Belongs to the HMG-CoA reductase family
HGMPKFMI_01587 4.8e-221 mvaS 2.3.3.10 I Hydroxymethylglutaryl-CoA synthase
HGMPKFMI_01588 2e-226 yjjP S Putative threonine/serine exporter
HGMPKFMI_01589 1.1e-89 ybaK S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HGMPKFMI_01590 4.2e-175 prmA J Ribosomal protein L11 methyltransferase
HGMPKFMI_01591 0.0 relA 2.7.6.5 KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HGMPKFMI_01592 1.1e-74 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
HGMPKFMI_01593 8.9e-245 hisS 6.1.1.21 J histidyl-tRNA synthetase
HGMPKFMI_01594 0.0 aspS 6.1.1.12 J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
HGMPKFMI_01595 5.4e-15
HGMPKFMI_01596 0.0 S Predicted membrane protein (DUF2207)
HGMPKFMI_01597 4.3e-184 K AI-2E family transporter
HGMPKFMI_01598 8.9e-173 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HGMPKFMI_01599 1e-32 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
HGMPKFMI_01600 1.6e-179 fabD 2.3.1.39 I Malonyl CoA-acyl carrier protein transacylase
HGMPKFMI_01601 6.3e-123 IQ reductase
HGMPKFMI_01602 3.9e-226 fabF 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
HGMPKFMI_01603 1e-68 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
HGMPKFMI_01604 1.9e-77 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
HGMPKFMI_01605 3.1e-259 accC 6.3.4.14, 6.4.1.2 I Acetyl-CoA carboxylase biotin carboxylase subunit
HGMPKFMI_01606 2.9e-159 accD 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HGMPKFMI_01607 6.7e-139 accA 2.1.3.15, 6.4.1.2 I alpha subunit
HGMPKFMI_01608 1.8e-125 fabI 1.3.1.10, 1.3.1.9 I Enoyl- acyl-carrier-protein reductase NADH
HGMPKFMI_01609 2.6e-123 birA 6.3.4.15 H Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
HGMPKFMI_01611 4e-49 S Domain of Unknown Function with PDB structure (DUF3862)
HGMPKFMI_01614 2.1e-17 G Polysaccharide deacetylase
HGMPKFMI_01615 7.8e-143 G polysaccharide deacetylase
HGMPKFMI_01616 1.6e-51 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
HGMPKFMI_01617 1.1e-149 adhE 1.1.1.1, 1.2.1.10 C Aldehyde dehydrogenase family
HGMPKFMI_01620 1.2e-26 L DDE superfamily endonuclease
HGMPKFMI_01624 8.4e-10 L COG3547 Transposase and inactivated derivatives
HGMPKFMI_01625 0.0 leuS 6.1.1.4 J Belongs to the class-I aminoacyl-tRNA synthetase family
HGMPKFMI_01626 1.3e-293 ytgP S Polysaccharide biosynthesis protein
HGMPKFMI_01627 1.2e-55 ppsA 2.7.9.2 G Belongs to the PEP-utilizing enzyme family
HGMPKFMI_01628 4.8e-60 ppsA 2.7.9.2 G Pyruvate phosphate dikinase, PEP/pyruvate binding domain
HGMPKFMI_01629 2.6e-160 ppsA 2.7.9.2 H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate
HGMPKFMI_01630 7.5e-57 ppsA 2.7.9.2 H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate
HGMPKFMI_01631 3.4e-67 ppsA 2.7.9.2 H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate
HGMPKFMI_01632 9.5e-153
HGMPKFMI_01633 4e-147 poxB 1.2.3.3, 1.2.5.1 EH Belongs to the TPP enzyme family
HGMPKFMI_01634 1.2e-48 poxB 1.2.3.3, 1.2.5.1 EH Belongs to the TPP enzyme family
HGMPKFMI_01635 1e-90 1.2.3.3, 3.7.1.22 EH Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
HGMPKFMI_01637 2.1e-230 dacA 3.4.16.4 M Belongs to the peptidase S11 family
HGMPKFMI_01638 5.6e-158 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HGMPKFMI_01639 5.7e-230 M ErfK YbiS YcfS YnhG
HGMPKFMI_01641 1.4e-11 L Putative transposase DNA-binding domain
HGMPKFMI_01642 3.7e-75 L Putative transposase DNA-binding domain
HGMPKFMI_01643 5.6e-57
HGMPKFMI_01644 5e-57 3.4.22.70 M Sortase family
HGMPKFMI_01645 4.5e-97 M ErfK YbiS YcfS YnhG
HGMPKFMI_01646 3.9e-170 fba 4.1.2.13, 4.1.2.29 G Fructose-1,6-bisphosphate aldolase, class II
HGMPKFMI_01647 5.3e-161 rluA 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
HGMPKFMI_01648 0.0 pbp2A 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
HGMPKFMI_01649 8.1e-55 yheA S Belongs to the UPF0342 family
HGMPKFMI_01650 8.7e-226 yhaO L Ser Thr phosphatase family protein
HGMPKFMI_01651 0.0 L AAA domain
HGMPKFMI_01652 1.1e-178 cbf S Metal dependent phosphohydrolases with conserved 'HD' motif.
HGMPKFMI_01653 3.3e-67 aroK 1.1.1.25, 2.7.1.71, 4.2.1.10, 4.2.3.4 F shikimate kinase activity
HGMPKFMI_01654 1.7e-51 aroA 1.3.1.12, 1.3.1.43, 2.5.1.19 E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
HGMPKFMI_01655 1.1e-156 prsA 5.2.1.8 M Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins
HGMPKFMI_01656 2.3e-113 pyrE 2.4.2.10, 4.1.1.23 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HGMPKFMI_01657 1.2e-132 pyrF 4.1.1.23 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
HGMPKFMI_01658 2.3e-170 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
HGMPKFMI_01659 8e-55
HGMPKFMI_01660 2.2e-78 hit FG Scavenger mRNA decapping enzyme C-term binding
HGMPKFMI_01661 2e-135 ecsA V ABC transporter, ATP-binding protein
HGMPKFMI_01662 3.3e-217 ecsB U ABC transporter
HGMPKFMI_01663 5.2e-124 trmB 2.1.1.297, 2.1.1.33 J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
HGMPKFMI_01664 1.2e-54 ytpP 2.7.1.180, 5.3.4.1 CO Thioredoxin
HGMPKFMI_01665 2.6e-120 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HGMPKFMI_01666 1.6e-252 mpl 6.3.2.4, 6.3.2.45, 6.3.2.8 M Belongs to the MurCDEF family
HGMPKFMI_01668 1.5e-13 EGP Major facilitator Superfamily
HGMPKFMI_01669 1.1e-113 EGP Major facilitator Superfamily
HGMPKFMI_01670 3.5e-39 EGP Major facilitator Superfamily
HGMPKFMI_01671 0.0 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HGMPKFMI_01672 2e-157 fpg 3.2.2.23, 4.2.99.18 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
HGMPKFMI_01673 2.5e-101 coaE 2.7.1.24 F Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HGMPKFMI_01674 2.7e-82 nrdR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HGMPKFMI_01675 4.4e-247 dnaB L Replication initiation and membrane attachment
HGMPKFMI_01676 1.5e-169 dnaI L Primosomal protein DnaI
HGMPKFMI_01677 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HGMPKFMI_01678 4.5e-274 S Archaea bacterial proteins of unknown function
HGMPKFMI_01679 5.4e-113 guaB2 L Resolvase, N terminal domain
HGMPKFMI_01680 8.1e-185 L Putative transposase DNA-binding domain
HGMPKFMI_01681 4.1e-74 L Putative transposase DNA-binding domain
HGMPKFMI_01682 2.6e-86 infC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HGMPKFMI_01683 1.8e-27 rpmI J Belongs to the bacterial ribosomal protein bL35 family
HGMPKFMI_01684 1.1e-56 rplT J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HGMPKFMI_01685 1e-212 yqeH S Ribosome biogenesis GTPase YqeH
HGMPKFMI_01686 2.9e-119 nadD 2.7.7.18, 3.6.1.55 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HGMPKFMI_01687 5.6e-109 nadD 2.7.6.3, 2.7.7.18 H Hydrolase, HD family
HGMPKFMI_01688 1.2e-58 rsfS J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
HGMPKFMI_01689 1.9e-214 ylbM S Belongs to the UPF0348 family
HGMPKFMI_01690 3.5e-100 yceD S Uncharacterized ACR, COG1399
HGMPKFMI_01691 2.9e-128 K response regulator
HGMPKFMI_01692 3e-290 arlS 2.7.13.3 T Histidine kinase
HGMPKFMI_01693 1.7e-155 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HGMPKFMI_01694 5.8e-45 acyP 3.6.1.7 C Belongs to the acylphosphatase family
HGMPKFMI_01695 4.9e-134 spoU 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HGMPKFMI_01696 7.5e-61 yodB K Transcriptional regulator, HxlR family
HGMPKFMI_01697 1.3e-198 pheS 6.1.1.20 J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HGMPKFMI_01698 0.0 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HGMPKFMI_01699 5.3e-81 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
HGMPKFMI_01700 0.0 S membrane
HGMPKFMI_01701 0.0 pbp2b 3.4.16.4 M Penicillin-binding Protein
HGMPKFMI_01702 7.2e-21 rpmG J Belongs to the bacterial ribosomal protein bL33 family
HGMPKFMI_01703 2.1e-105 ygfA 6.3.3.2 H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HGMPKFMI_01704 5.9e-115 gluP 3.4.21.105 S Rhomboid family
HGMPKFMI_01705 8.2e-32 yqgQ S Bacterial protein of unknown function (DUF910)
HGMPKFMI_01706 2.6e-70 yqhL P Rhodanese-like protein
HGMPKFMI_01707 5.2e-170 miaA 2.5.1.75 F Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HGMPKFMI_01708 1e-107 ynbB 4.4.1.1 P aluminum resistance
HGMPKFMI_01709 8.2e-78 ynbB 4.4.1.1 P aluminum resistance
HGMPKFMI_01710 2.8e-257 glnA 6.3.1.2 E glutamine synthetase
HGMPKFMI_01711 3.3e-217 EGP Major facilitator Superfamily
HGMPKFMI_01712 1.2e-64 S Domain of unknown function DUF1828
HGMPKFMI_01713 7.7e-58
HGMPKFMI_01714 1.5e-186 add 3.5.4.4 F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HGMPKFMI_01715 3.4e-203 pepO 3.4.24.71 O Peptidase family M13
HGMPKFMI_01716 2.6e-230 cfa 2.1.1.317, 2.1.1.79 M cyclopropane-fatty-acyl-phospholipid synthase
HGMPKFMI_01717 3.3e-23 L Transposase
HGMPKFMI_01718 4e-73 L DDE superfamily endonuclease
HGMPKFMI_01719 1.4e-170 cysK 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
HGMPKFMI_01722 1.3e-27 dmpI 5.3.2.6 G Belongs to the 4-oxalocrotonate tautomerase family
HGMPKFMI_01723 9.5e-57 qorB 1.6.5.2 GM NmrA-like family
HGMPKFMI_01724 2.8e-32 qorB 1.6.5.2 GM epimerase
HGMPKFMI_01725 9.7e-68 K Transcriptional regulator
HGMPKFMI_01726 1.9e-83 S YcxB-like protein
HGMPKFMI_01727 8.2e-99 T integral membrane protein
HGMPKFMI_01728 0.0 L Helicase C-terminal domain protein
HGMPKFMI_01729 2.9e-91 S ECF-type riboflavin transporter, S component
HGMPKFMI_01730 1.8e-153 pdxK 2.7.1.35 H Phosphomethylpyrimidine kinase
HGMPKFMI_01731 9.5e-29 K Acetyltransferase (GNAT) domain
HGMPKFMI_01732 9.4e-11 K Acetyltransferase (GNAT) domain
HGMPKFMI_01733 1e-175 lysA2 M Glycosyl hydrolases family 25
HGMPKFMI_01734 1.7e-11
HGMPKFMI_01735 3.3e-130 ybbM S Uncharacterised protein family (UPF0014)
HGMPKFMI_01736 2e-112 ybbL S ABC transporter, ATP-binding protein
HGMPKFMI_01738 1.4e-139 V ABC-type multidrug transport system, ATPase and permease components
HGMPKFMI_01739 3.4e-59 V ABC-type multidrug transport system, ATPase and permease components
HGMPKFMI_01740 1.2e-146 L the current gene model (or a revised gene model) may contain a frame shift
HGMPKFMI_01741 1.2e-12 L transposase and inactivated derivatives, IS30 family
HGMPKFMI_01743 1.5e-121 yhiD S MgtC family
HGMPKFMI_01745 1.1e-68
HGMPKFMI_01746 0.0 V ATPases associated with a variety of cellular activities
HGMPKFMI_01747 8.1e-229 MA20_36090 S Protein of unknown function (DUF2974)
HGMPKFMI_01748 5.7e-250 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
HGMPKFMI_01749 4e-75 rplI J Binds to the 23S rRNA
HGMPKFMI_01750 0.0 yybT T signaling protein consisting of a modified GGDEF domain and a DHH domain
HGMPKFMI_01751 3.3e-36 rpsR J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HGMPKFMI_01752 1.4e-88 ssb L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
HGMPKFMI_01753 5.1e-47 rpsF J Binds together with S18 to 16S ribosomal RNA
HGMPKFMI_01754 0.0 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HGMPKFMI_01755 0.0 gyrB 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HGMPKFMI_01756 1.7e-210 recF L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HGMPKFMI_01757 2.2e-37 yaaA S S4 domain protein YaaA
HGMPKFMI_01758 9e-201 dnaN 2.7.7.7 L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
HGMPKFMI_01759 3e-243 dnaA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HGMPKFMI_01760 1.1e-15 rpmH J Belongs to the bacterial ribosomal protein bL34 family
HGMPKFMI_01761 1.4e-62 rnpA 3.1.26.5 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
HGMPKFMI_01762 4.9e-146 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HGMPKFMI_01763 1.1e-251 mnmE S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HGMPKFMI_01764 0.0 gidA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
HGMPKFMI_01765 0.0 poxB 1.2.3.3, 1.2.5.1 EH Belongs to the TPP enzyme family
HGMPKFMI_01766 1.2e-268 gnd 1.1.1.343, 1.1.1.44 H Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HGMPKFMI_01767 5.4e-104
HGMPKFMI_01768 1e-81 XK27_08850 S Aminoacyl-tRNA editing domain
HGMPKFMI_01769 4.9e-282 clcA P chloride
HGMPKFMI_01770 3.7e-230 pbuG S permease
HGMPKFMI_01771 5.5e-138 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
HGMPKFMI_01772 3.8e-268 glnP P ABC transporter
HGMPKFMI_01773 2.2e-128 dak 2.7.1.74, 2.7.1.76 F deoxynucleoside kinase
HGMPKFMI_01774 2.6e-123 dak 2.7.1.74, 2.7.1.76 F deoxynucleoside kinase
HGMPKFMI_01775 2.9e-38
HGMPKFMI_01776 5.5e-164 3.2.1.17 M peptidoglycan-binding domain-containing protein
HGMPKFMI_01778 1.2e-13 L PFAM Integrase catalytic region
HGMPKFMI_01780 4.4e-121 nagB 3.1.1.31, 3.5.99.6 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
HGMPKFMI_01781 2.4e-158 yeaE S Aldo/keto reductase family
HGMPKFMI_01782 2.5e-21 EGP Major facilitator Superfamily
HGMPKFMI_01783 3.7e-171 yufQ S Belongs to the binding-protein-dependent transport system permease family
HGMPKFMI_01784 1.8e-204 yufP S Belongs to the binding-protein-dependent transport system permease family
HGMPKFMI_01785 2.1e-285 xylG 3.6.3.17 S ABC transporter
HGMPKFMI_01786 2.3e-193 tcsA S ABC transporter substrate-binding protein PnrA-like
HGMPKFMI_01787 6.3e-191 tcsA S ABC transporter substrate-binding protein PnrA-like
HGMPKFMI_01788 5.1e-70 S Domain of unknown function (DUF4352)
HGMPKFMI_01789 1.1e-187 KLT Protein tyrosine kinase
HGMPKFMI_01790 1.4e-66 S Psort location Cytoplasmic, score
HGMPKFMI_01792 3e-193 tcsA S ABC transporter substrate-binding protein PnrA-like
HGMPKFMI_01793 1.2e-200 S DUF218 domain
HGMPKFMI_01794 2.2e-122 S CAAX protease self-immunity
HGMPKFMI_01795 3.2e-201 napA P Sodium/hydrogen exchanger family
HGMPKFMI_01796 0.0 cadA P P-type ATPase
HGMPKFMI_01797 4.7e-85 ykuL S (CBS) domain
HGMPKFMI_01798 1.3e-224 ywhK S Membrane
HGMPKFMI_01799 1.3e-45
HGMPKFMI_01801 2.9e-295 dltA 6.1.1.13 H Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HGMPKFMI_01802 1.3e-240 dltB M MBOAT, membrane-bound O-acyltransferase family
HGMPKFMI_01803 2e-36 dltC 6.1.1.13 J Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HGMPKFMI_01804 7.3e-247 dltD M Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HGMPKFMI_01806 3.8e-66 S Iron-sulphur cluster biosynthesis
HGMPKFMI_01807 0.0 yhcA V ABC transporter, ATP-binding protein
HGMPKFMI_01808 8.5e-116 K Bacterial regulatory proteins, tetR family
HGMPKFMI_01809 8.4e-10 L COG3547 Transposase and inactivated derivatives
HGMPKFMI_01810 8.4e-10 L COG3547 Transposase and inactivated derivatives
HGMPKFMI_01811 6.1e-88 L COG3547 Transposase and inactivated derivatives
HGMPKFMI_01812 1.8e-107 L DDE superfamily endonuclease
HGMPKFMI_01813 2.1e-22 L DDE superfamily endonuclease
HGMPKFMI_01814 3.8e-42 L DDE superfamily endonuclease
HGMPKFMI_01815 3e-187 manL 2.7.1.191 G PTS system sorbose subfamily IIB component
HGMPKFMI_01816 5.4e-139 manY G PTS system
HGMPKFMI_01817 2.4e-167 manN G system, mannose fructose sorbose family IID component
HGMPKFMI_01818 8.1e-63 manO S Domain of unknown function (DUF956)
HGMPKFMI_01820 4.5e-247 cycA E Amino acid permease
HGMPKFMI_01821 2.1e-162 3.5.2.6 M NlpC/P60 family
HGMPKFMI_01823 9.6e-08 K Helix-turn-helix domain
HGMPKFMI_01824 1.6e-188 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
HGMPKFMI_01825 0.0 recQ1 L Helicase conserved C-terminal domain
HGMPKFMI_01826 2.4e-47
HGMPKFMI_01827 1.3e-18 K sequence-specific DNA binding
HGMPKFMI_01829 3e-221 oxlT P Major Facilitator Superfamily
HGMPKFMI_01830 2.3e-13 malS 3.2.1.1 GH13 G Glycogen debranching enzyme, glucanotransferase domain
HGMPKFMI_01831 3.8e-112 malS 3.2.1.1 GH13 G Glycogen debranching enzyme, glucanotransferase domain
HGMPKFMI_01832 2.2e-72 malS 3.2.1.1 GH13 G Glycogen debranching enzyme, glucanotransferase domain
HGMPKFMI_01834 3.6e-204 L COG2826 Transposase and inactivated derivatives, IS30 family
HGMPKFMI_01835 1.6e-198 G Major Facilitator Superfamily
HGMPKFMI_01836 1.8e-53 L Transposase and inactivated derivatives, IS30 family
HGMPKFMI_01837 2.9e-276 E Amino acid permease
HGMPKFMI_01838 0.0 yaaO 4.1.1.17, 4.1.1.19 E Orn/Lys/Arg decarboxylase, C-terminal domain
HGMPKFMI_01839 8.9e-238 malQ 2.4.1.25, 3.2.1.20, 3.2.1.41 CBM48,GH13,GH31,GH77 G Belongs to the glycosyl hydrolase 13 family
HGMPKFMI_01840 0.0 pgm 5.4.2.2, 5.4.2.8 G Phosphoglucomutase phosphomannomutase, alpha beta alpha domain
HGMPKFMI_01841 1.9e-200 pfkA 2.7.1.11, 2.7.1.90 F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
HGMPKFMI_01842 7.8e-79 2.7.1.199, 2.7.1.211 G phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1
HGMPKFMI_01843 2.7e-51 scrB 3.2.1.26 GH32 G invertase
HGMPKFMI_01844 5.1e-111 scrB 3.2.1.26 GH32 G invertase
HGMPKFMI_01845 2.4e-95 scrR K Transcriptional regulator, LacI family
HGMPKFMI_01846 7.7e-25
HGMPKFMI_01847 1.5e-106 yiiE S Protein of unknown function (DUF1211)
HGMPKFMI_01848 7.2e-100 K Acetyltransferase (GNAT) domain
HGMPKFMI_01852 4.3e-283 thrC 4.2.3.1 E Threonine synthase
HGMPKFMI_01853 7.2e-158 thrB 2.7.1.39 F Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
HGMPKFMI_01857 6e-83 M LysM domain protein
HGMPKFMI_01858 1.8e-35 D nuclear chromosome segregation
HGMPKFMI_01859 2.8e-96 D nuclear chromosome segregation
HGMPKFMI_01860 8e-252 aspA 4.2.1.2, 4.3.1.1 E Fumarase C C-terminus
HGMPKFMI_01861 3.4e-08 lacR K DeoR C terminal sensor domain
HGMPKFMI_01862 3.7e-166 cycA E Amino acid permease
HGMPKFMI_01863 1.5e-46 cycA E Amino acid permease
HGMPKFMI_01864 1.1e-275 pepV 3.5.1.18 E dipeptidase PepV
HGMPKFMI_01865 1.1e-136 ybbH_2 K Helix-turn-helix domain, rpiR family
HGMPKFMI_01866 7.3e-103 3.5.2.6 V Beta-lactamase
HGMPKFMI_01867 8.8e-09 3.5.2.6 V Beta-lactamase
HGMPKFMI_01868 4.8e-196 ykfB 5.1.1.20 M Belongs to the mandelate racemase muconate lactonizing enzyme family
HGMPKFMI_01869 1.5e-94 wecD K Acetyltransferase (GNAT) family
HGMPKFMI_01870 2.3e-107 thiJ 2.7.11.1, 3.5.1.124 S DJ-1/PfpI family
HGMPKFMI_01871 4.8e-118 S membrane transporter protein
HGMPKFMI_01872 4.7e-128 pgm3 G Belongs to the phosphoglycerate mutase family
HGMPKFMI_01873 2.6e-28
HGMPKFMI_01874 5.2e-29
HGMPKFMI_01875 1.1e-124 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HGMPKFMI_01876 2.1e-79 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
HGMPKFMI_01877 2.4e-183 S AAA domain
HGMPKFMI_01879 3.6e-265 pepC 3.4.22.40 E Peptidase C1-like family
HGMPKFMI_01880 5.4e-49
HGMPKFMI_01881 3.4e-100 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F dUTP diphosphatase
HGMPKFMI_01882 6.6e-254 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HGMPKFMI_01883 9e-186 arbY M Glycosyl transferase family 8
HGMPKFMI_01884 1.2e-64 yliE T domain protein
HGMPKFMI_01885 8e-151 yliE T Putative diguanylate phosphodiesterase

eggNOG-mapper v2 (Database: eggNOG v5.0, Jul. 2018 release)