ORF_ID e_value Gene_name EC_number CAZy COGs Description
HKDCBFDG_00001 5.2e-173 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
HKDCBFDG_00003 5.2e-53
HKDCBFDG_00004 5.8e-177 prmA J Ribosomal protein L11 methyltransferase
HKDCBFDG_00005 5.7e-135 rsmE 2.1.1.193 J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
HKDCBFDG_00006 4.4e-58
HKDCBFDG_00007 0.0 relA 2.7.6.5 KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HKDCBFDG_00008 2.4e-77 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
HKDCBFDG_00009 3.9e-84 slyA K Transcriptional regulator
HKDCBFDG_00010 3.6e-216 metC1 2.5.1.48, 4.4.1.8 E cystathionine
HKDCBFDG_00011 1.4e-209 metB 2.5.1.48, 4.4.1.8 E Cys/Met metabolism PLP-dependent enzyme
HKDCBFDG_00013 1.6e-112 papP P ABC transporter, permease protein
HKDCBFDG_00014 2.2e-106 P ABC transporter permease
HKDCBFDG_00015 3.9e-136 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
HKDCBFDG_00016 2.6e-152 cjaA ET ABC transporter substrate-binding protein
HKDCBFDG_00017 6.1e-137 IQ KR domain
HKDCBFDG_00018 1.4e-212 hom1 1.1.1.3 E Homoserine dehydrogenase
HKDCBFDG_00019 2.2e-159 metAA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to
HKDCBFDG_00020 4e-246 mmuP E amino acid
HKDCBFDG_00021 1.1e-172 mmuM 1.5.1.20, 2.1.1.10 H homocysteine S-methyltransferase
HKDCBFDG_00022 3.4e-168 yniA G Phosphotransferase enzyme family
HKDCBFDG_00023 6.9e-173 lytH 3.5.1.28 M Ami_3
HKDCBFDG_00024 4.7e-196 6.3.1.20 H Lipoate-protein ligase
HKDCBFDG_00025 1.9e-247 hisS 6.1.1.21 J histidyl-tRNA synthetase
HKDCBFDG_00026 0.0 aspS 6.1.1.12 J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
HKDCBFDG_00027 1.5e-129 yfeJ 6.3.5.2 F glutamine amidotransferase
HKDCBFDG_00028 5.7e-23 rpsU J Belongs to the bacterial ribosomal protein bS21 family
HKDCBFDG_00029 4.6e-71 yqeY S YqeY-like protein
HKDCBFDG_00030 1.1e-178 phoH T phosphate starvation-inducible protein PhoH
HKDCBFDG_00031 1.1e-80 ybeY 2.6.99.2, 3.5.4.5 S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HKDCBFDG_00032 1e-66 dgkA 2.7.1.107, 2.7.1.66 M Diacylglycerol kinase
HKDCBFDG_00033 8.7e-170 era S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HKDCBFDG_00034 2.9e-156 recO L Involved in DNA repair and RecF pathway recombination
HKDCBFDG_00035 4.9e-187 glyQ 6.1.1.14 J glycyl-tRNA synthetase alpha subunit
HKDCBFDG_00036 0.0 glyS 6.1.1.14 J Glycyl-tRNA synthetase beta subunit
HKDCBFDG_00037 0.0 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
HKDCBFDG_00038 3.8e-207 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
HKDCBFDG_00039 5.1e-99 IQ Enoyl-(Acyl carrier protein) reductase
HKDCBFDG_00040 1.8e-128 EGP Major facilitator Superfamily
HKDCBFDG_00041 1.1e-169 apbE 2.7.1.180 H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
HKDCBFDG_00042 3.3e-178 dapF 5.1.1.7 E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HKDCBFDG_00043 5e-262 lysC 2.7.2.4 E Belongs to the aspartokinase family
HKDCBFDG_00044 2.4e-253 lysA 4.1.1.19, 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
HKDCBFDG_00045 2.9e-72 dapD 2.3.1.117, 2.3.1.89 E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
HKDCBFDG_00046 5.2e-220 hipO 3.5.1.47 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
HKDCBFDG_00047 1.1e-172 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HKDCBFDG_00048 2.3e-139 dapB 1.17.1.8 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
HKDCBFDG_00049 1.6e-216 patA 2.6.1.1 E Aminotransferase
HKDCBFDG_00050 2.8e-196 asd 1.2.1.11 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HKDCBFDG_00051 6.7e-227 ktrB P Potassium uptake protein
HKDCBFDG_00052 2.8e-117 ktrA P domain protein
HKDCBFDG_00053 1.7e-125 trmK 2.1.1.217 S SAM-dependent methyltransferase
HKDCBFDG_00054 1.1e-155 yqfO 3.5.4.16 S Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HKDCBFDG_00055 5.6e-236 pepT 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
HKDCBFDG_00057 0.0 dnaE 2.7.7.7 L DNA polymerase
HKDCBFDG_00058 2.4e-267 pyk 2.7.1.40, 2.7.7.4 G Belongs to the pyruvate kinase family
HKDCBFDG_00059 1.6e-168 cvfB S S1 domain
HKDCBFDG_00060 8.2e-133 xerD D recombinase XerD
HKDCBFDG_00061 3.4e-67 ribT K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HKDCBFDG_00062 3.9e-142 scpA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HKDCBFDG_00063 5e-102 scpB D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HKDCBFDG_00064 2.8e-131 rluB 5.4.99.19, 5.4.99.21, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
HKDCBFDG_00065 3.7e-81 U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HKDCBFDG_00066 6e-199 ypbB 5.1.3.1 S Helix-turn-helix domain
HKDCBFDG_00067 3.1e-278 recQ1 3.6.4.12 L ATP-dependent DNA helicase RecQ
HKDCBFDG_00068 9.7e-31 M Lysin motif
HKDCBFDG_00069 2e-118 cmk 1.17.7.4, 2.5.1.19, 2.7.1.26, 2.7.4.25, 2.7.7.2, 6.3.2.1 F Belongs to the cytidylate kinase family. Type 1 subfamily
HKDCBFDG_00070 5.8e-209 rpsA 1.17.7.4 J Ribosomal protein S1
HKDCBFDG_00071 2.6e-247 der 1.1.1.399, 1.1.1.95 S GTPase that plays an essential role in the late steps of ribosome biogenesis
HKDCBFDG_00072 4.4e-40 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
HKDCBFDG_00073 1.8e-234 S Tetratricopeptide repeat protein
HKDCBFDG_00074 4.7e-165 xerD L Phage integrase, N-terminal SAM-like domain
HKDCBFDG_00075 3.1e-223 cca 2.7.7.19, 2.7.7.72 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HKDCBFDG_00076 0.0 yfmR S ABC transporter, ATP-binding protein
HKDCBFDG_00077 8e-190 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HKDCBFDG_00078 8.7e-95 folA 1.5.1.3 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HKDCBFDG_00079 1.2e-109 hlyIII S protein, hemolysin III
HKDCBFDG_00080 1.3e-151 DegV S EDD domain protein, DegV family
HKDCBFDG_00081 1.2e-219 1.1.1.399, 1.1.1.95 EH D-isomer specific 2-hydroxyacid dehydrogenase
HKDCBFDG_00082 2.2e-108 cat S Bacterial transferase hexapeptide (six repeats)
HKDCBFDG_00083 1.1e-167 ypmR E lipolytic protein G-D-S-L family
HKDCBFDG_00084 7.1e-104 ypmS S Uncharacterized protein conserved in bacteria (DUF2140)
HKDCBFDG_00085 3.1e-36 yozE S Belongs to the UPF0346 family
HKDCBFDG_00086 1.2e-160 ylqF S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HKDCBFDG_00087 1e-139 rnhB 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HKDCBFDG_00088 4.8e-165 dprA LU DNA protecting protein DprA
HKDCBFDG_00089 0.0 topA 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HKDCBFDG_00090 7.3e-155 D DNA integration
HKDCBFDG_00091 4e-172 lacX 5.1.3.3 G Aldose 1-epimerase
HKDCBFDG_00092 2.8e-103 plsY 2.3.1.15, 3.5.1.104 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
HKDCBFDG_00093 0.0 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HKDCBFDG_00094 0.0 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HKDCBFDG_00095 5.2e-95 S Protein of unknown function (DUF1440)
HKDCBFDG_00096 7.3e-172 ppaC 3.6.1.1 C inorganic pyrophosphatase
HKDCBFDG_00097 2.3e-71 yqkB S Belongs to the HesB IscA family
HKDCBFDG_00098 3.8e-75 msrB 1.8.4.11, 1.8.4.12 O peptide methionine sulfoxide reductase
HKDCBFDG_00099 5.7e-94 ywnH 2.3.1.183 M Acetyltransferase (GNAT) domain
HKDCBFDG_00100 1.3e-81 yebR 1.8.4.14 T GAF domain-containing protein
HKDCBFDG_00101 2.1e-244 U Belongs to the purine-cytosine permease (2.A.39) family
HKDCBFDG_00102 2.3e-242 codA 3.5.4.1 F cytosine deaminase
HKDCBFDG_00103 0.0 oppD EP Psort location Cytoplasmic, score
HKDCBFDG_00105 4.5e-255 rarA L recombination factor protein RarA
HKDCBFDG_00106 5.9e-79 S Protein of unknown function (DUF554)
HKDCBFDG_00107 1.1e-21 S Protein of unknown function (DUF554)
HKDCBFDG_00108 1.2e-244 yhjX P Major Facilitator Superfamily
HKDCBFDG_00109 6.5e-18 lmrB EGP Major facilitator Superfamily
HKDCBFDG_00110 3.2e-51 clcA P chloride
HKDCBFDG_00111 5.6e-156 odh 1.5.1.28 C NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain
HKDCBFDG_00112 5.9e-119 5.1.1.13 M racemase activity, acting on amino acids and derivatives
HKDCBFDG_00113 3e-260 arcD E Amino acid permease
HKDCBFDG_00114 1.3e-198 ilvE 2.6.1.42 E Branched-chain amino acid aminotransferase
HKDCBFDG_00115 1.1e-107 lacA 2.3.1.18, 2.3.1.79 S Maltose acetyltransferase
HKDCBFDG_00116 1.2e-39 yncA 2.3.1.18, 2.3.1.79 S Maltose acetyltransferase
HKDCBFDG_00117 1.4e-62 S Fic/DOC family
HKDCBFDG_00118 6.9e-22 S Fic/DOC family
HKDCBFDG_00119 1.9e-95 apt 2.4.2.22, 2.4.2.7 F Phosphoribosyl transferase domain
HKDCBFDG_00120 5e-246 EGP Sugar (and other) transporter
HKDCBFDG_00121 3.8e-16 1.4.1.1, 4.3.1.12 E Ornithine cyclodeaminase/mu-crystallin family
HKDCBFDG_00122 4.1e-156 1.4.1.1, 4.3.1.12 E Ornithine cyclodeaminase/mu-crystallin family
HKDCBFDG_00123 1.4e-214 2.6.1.1 E Aminotransferase
HKDCBFDG_00125 3.7e-105 S Phage minor capsid protein 2
HKDCBFDG_00126 8.6e-116 dck 2.7.1.74 F deoxynucleoside kinase
HKDCBFDG_00127 1.4e-110
HKDCBFDG_00128 9.9e-183 rbsR K Periplasmic binding proteins and sugar binding domain of LacI family
HKDCBFDG_00129 5.8e-118 S CAAX protease self-immunity
HKDCBFDG_00130 8.4e-63 folB 1.13.11.81, 2.5.1.15, 2.7.6.3, 4.1.2.25, 5.1.99.8 H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HKDCBFDG_00131 1.5e-94 folK 1.13.11.81, 2.5.1.15, 2.7.6.3, 3.5.4.16, 4.1.2.25, 5.1.99.8 H 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)
HKDCBFDG_00132 4.9e-102 folE 2.7.6.3, 3.5.4.16 F GTP cyclohydrolase 1
HKDCBFDG_00133 1e-240 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
HKDCBFDG_00134 1.1e-104 xtp 2.5.1.15, 3.6.1.66 F Ham1 family
HKDCBFDG_00135 3.2e-198 folP 2.5.1.15 H dihydropteroate synthase
HKDCBFDG_00137 5.5e-35
HKDCBFDG_00139 0.0 argS 6.1.1.19 J Arginyl-tRNA synthetase
HKDCBFDG_00140 0.0 pbp2A 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
HKDCBFDG_00141 9.8e-56 yheA S Belongs to the UPF0342 family
HKDCBFDG_00142 1.8e-178 yhaM S Metal dependent phosphohydrolases with conserved 'HD' motif.
HKDCBFDG_00143 2e-148 prsA 5.2.1.8 M Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins
HKDCBFDG_00145 1.4e-77 hit FG histidine triad
HKDCBFDG_00146 2.3e-133 ecsA V ABC transporter, ATP-binding protein
HKDCBFDG_00147 3.3e-209 ecsB U ABC transporter
HKDCBFDG_00148 1.8e-124 trmB 2.1.1.297, 2.1.1.33 J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
HKDCBFDG_00149 3.3e-58 ytzB S Small secreted protein
HKDCBFDG_00150 6.5e-56 ytpP 2.7.1.180, 5.3.4.1 CO Thioredoxin
HKDCBFDG_00151 5.9e-117 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HKDCBFDG_00152 4.2e-250 mpl 6.3.2.4, 6.3.2.45, 6.3.2.8 M Belongs to the MurCDEF family
HKDCBFDG_00153 1.8e-114 ybhL S Belongs to the BI1 family
HKDCBFDG_00154 1.5e-138 aroD S Serine hydrolase (FSH1)
HKDCBFDG_00155 0.0 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HKDCBFDG_00156 2.1e-162 fpg 3.2.2.23, 4.2.99.18 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
HKDCBFDG_00157 3.5e-106 coaE 2.7.1.24 F Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HKDCBFDG_00158 8.5e-81 nrdR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HKDCBFDG_00159 2.6e-250 dnaB L replication initiation and membrane attachment
HKDCBFDG_00160 4.8e-171 dnaI L Primosomal protein DnaI
HKDCBFDG_00161 1.7e-85 infC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HKDCBFDG_00162 1.5e-26 rpmI J Belongs to the bacterial ribosomal protein bL35 family
HKDCBFDG_00163 6.6e-57 rplT J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HKDCBFDG_00164 1.9e-19 yoaK S Protein of unknown function (DUF1275)
HKDCBFDG_00165 1.8e-23 yoaK S Protein of unknown function (DUF1275)
HKDCBFDG_00166 2.2e-96 yqeG S HAD phosphatase, family IIIA
HKDCBFDG_00167 7.6e-216 yqeH S Ribosome biogenesis GTPase YqeH
HKDCBFDG_00168 2.6e-49 yhbY J RNA-binding protein
HKDCBFDG_00169 1.2e-93 nadD 2.7.7.18, 3.6.1.55 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HKDCBFDG_00170 7.3e-112 nadD 2.7.6.3, 2.7.7.18 H Hydrolase, HD family
HKDCBFDG_00171 6.1e-58 rsfS J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
HKDCBFDG_00172 1.4e-139 yqeM Q Methyltransferase
HKDCBFDG_00173 9.3e-214 ylbM S Belongs to the UPF0348 family
HKDCBFDG_00174 3.5e-97 yceD S Uncharacterized ACR, COG1399
HKDCBFDG_00175 7.2e-28 rpmF J Belongs to the bacterial ribosomal protein bL32 family
HKDCBFDG_00176 1.6e-120 K response regulator
HKDCBFDG_00177 2e-280 arlS 2.7.13.3 T Histidine kinase
HKDCBFDG_00178 2.3e-232 V MatE
HKDCBFDG_00179 4.3e-68 def_1 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins
HKDCBFDG_00180 5e-141 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HKDCBFDG_00181 4.1e-46 acyP 3.6.1.7 C Belongs to the acylphosphatase family
HKDCBFDG_00182 2.9e-140 spoU 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HKDCBFDG_00183 2.2e-90 XK27_09705 6.1.1.14 S Metal dependent phosphohydrolases with conserved 'HD' motif.
HKDCBFDG_00184 7.8e-60 yodB K Transcriptional regulator, HxlR family
HKDCBFDG_00185 2.5e-197 pheS 6.1.1.20 J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HKDCBFDG_00186 0.0 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HKDCBFDG_00187 1.4e-116 udk 2.7.1.48 F Cytidine monophosphokinase
HKDCBFDG_00188 6.3e-79 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
HKDCBFDG_00189 0.0 S membrane
HKDCBFDG_00190 0.0 pbp2b 3.4.16.4 M Penicillin-binding Protein
HKDCBFDG_00191 3.2e-21 rpmG J Belongs to the bacterial ribosomal protein bL33 family
HKDCBFDG_00192 2.7e-97 ygfA 6.3.3.2 H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HKDCBFDG_00193 1.5e-104 gluP 3.4.21.105 S Peptidase, S54 family
HKDCBFDG_00194 9.6e-36 yqgQ S Bacterial protein of unknown function (DUF910)
HKDCBFDG_00195 1.4e-178 glk 2.7.1.2 G Glucokinase
HKDCBFDG_00196 1.5e-71 yqhL P Rhodanese-like protein
HKDCBFDG_00197 4.8e-24 WQ51_02665 S Protein of unknown function (DUF3042)
HKDCBFDG_00198 8.5e-173 miaA 2.5.1.75 F Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HKDCBFDG_00199 6e-260 glnA 6.3.1.2 E glutamine synthetase
HKDCBFDG_00200 4.7e-13
HKDCBFDG_00201 9.2e-148
HKDCBFDG_00202 4.3e-175
HKDCBFDG_00203 6.6e-93 dut S Protein conserved in bacteria
HKDCBFDG_00205 1.4e-113 K Transcriptional regulator
HKDCBFDG_00206 1.8e-50 rplU J This protein binds to 23S rRNA in the presence of protein L20
HKDCBFDG_00207 9e-53 ysxB J Cysteine protease Prp
HKDCBFDG_00208 7.1e-46 rpmA J Belongs to the bacterial ribosomal protein bL27 family
HKDCBFDG_00209 1.8e-206 pepP 3.4.11.9, 3.4.13.9 E Creatinase/Prolidase N-terminal domain
HKDCBFDG_00210 4.1e-72 yqhY S Asp23 family, cell envelope-related function
HKDCBFDG_00211 9.8e-68 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HKDCBFDG_00212 1e-159 folD 1.5.1.5, 3.5.4.9 F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HKDCBFDG_00213 2.3e-257 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HKDCBFDG_00214 1e-18 xseB 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HKDCBFDG_00215 6.2e-157 ispA 2.5.1.1, 2.5.1.10, 2.5.1.29, 2.5.1.90 H Belongs to the FPP GGPP synthase family
HKDCBFDG_00216 1.9e-147 rrmJ 2.1.1.226, 2.1.1.227 J Ribosomal RNA large subunit methyltransferase J
HKDCBFDG_00217 6.2e-76 argR K Regulates arginine biosynthesis genes
HKDCBFDG_00218 1.3e-307 recN L May be involved in recombinational repair of damaged DNA
HKDCBFDG_00219 5.6e-15
HKDCBFDG_00220 6.7e-113 gmk 2.7.4.8 F Essential for recycling GMP and indirectly, cGMP
HKDCBFDG_00221 3.2e-46 rpoZ 2.7.7.6 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
HKDCBFDG_00222 1.2e-219 coaBC 4.1.1.36, 6.3.2.5 H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HKDCBFDG_00223 0.0 priA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HKDCBFDG_00224 3.3e-172 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HKDCBFDG_00225 1.9e-245 sun 2.1.1.176 J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HKDCBFDG_00226 5.5e-130 stp 3.1.3.16 T phosphatase
HKDCBFDG_00227 0.0 KLT serine threonine protein kinase
HKDCBFDG_00228 1.7e-165 rsgA 3.1.3.100 S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
HKDCBFDG_00229 7.2e-118 rpe 5.1.3.1 G Belongs to the ribulose-phosphate 3-epimerase family
HKDCBFDG_00230 3.1e-124 thiN 2.7.6.2 H thiamine pyrophosphokinase
HKDCBFDG_00231 1.4e-26 rpmB J Belongs to the bacterial ribosomal protein bL28 family
HKDCBFDG_00232 3.6e-58 asp S Asp23 family, cell envelope-related function
HKDCBFDG_00233 1.6e-294 yloV S DAK2 domain fusion protein YloV
HKDCBFDG_00234 0.0 recG 3.6.4.12 L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HKDCBFDG_00235 2.8e-164 plsX 2.3.1.15 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
HKDCBFDG_00236 4.5e-36 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
HKDCBFDG_00237 3.4e-129 rnc 3.1.26.3 J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
HKDCBFDG_00238 0.0 smc D Required for chromosome condensation and partitioning
HKDCBFDG_00239 6.8e-178 ftsY U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HKDCBFDG_00240 3.7e-57 ylxM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HKDCBFDG_00241 5.8e-245 ffh 3.6.5.4 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HKDCBFDG_00244 9.8e-129 K Transcriptional regulatory protein, C-terminal domain protein
HKDCBFDG_00245 5.1e-159 pstS P Phosphate
HKDCBFDG_00246 1.9e-153 pstC P probably responsible for the translocation of the substrate across the membrane
HKDCBFDG_00247 9.4e-153 pstA P Phosphate transport system permease protein PstA
HKDCBFDG_00248 1.7e-134 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
HKDCBFDG_00249 3.1e-122 phoU P Plays a role in the regulation of phosphate uptake
HKDCBFDG_00250 2.9e-44 rpsP J Belongs to the bacterial ribosomal protein bS16 family
HKDCBFDG_00251 6e-39 ylqC S Belongs to the UPF0109 family
HKDCBFDG_00252 2.1e-88 rimM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HKDCBFDG_00253 2.9e-142 trmD 2.1.1.228, 4.6.1.12 J Belongs to the RNA methyltransferase TrmD family
HKDCBFDG_00254 1.1e-259 yfnA E Amino Acid
HKDCBFDG_00255 2.1e-58 rplS J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
HKDCBFDG_00256 1.8e-295 cas3 L CRISPR-associated helicase cas3
HKDCBFDG_00257 3.4e-156 casA L the current gene model (or a revised gene model) may contain a frame shift
HKDCBFDG_00258 5.4e-40 casB S CRISPR-associated protein Cse2 (CRISPR_cse2)
HKDCBFDG_00259 1.2e-128 casC L CT1975-like protein
HKDCBFDG_00260 1.2e-65 casD S CRISPR-associated protein (Cas_Cas5)
HKDCBFDG_00261 1.8e-71 casE S CRISPR_assoc
HKDCBFDG_00262 3.2e-127 cas1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HKDCBFDG_00263 4e-79 cas2 2.7.7.7 L CRISPR-associated protein (Cas_Cas2CT1978)
HKDCBFDG_00264 8.9e-264 pepC 3.4.22.40 E Peptidase C1-like family
HKDCBFDG_00265 4e-94 maa 2.3.1.18, 2.3.1.79 S Transferase hexapeptide repeat
HKDCBFDG_00266 1.8e-122 rpiA 2.7.1.12, 5.3.1.6 G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HKDCBFDG_00267 1.1e-52 HA62_12640 S GCN5-related N-acetyl-transferase
HKDCBFDG_00268 2e-97 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F dUTP diphosphatase
HKDCBFDG_00269 1.4e-251 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HKDCBFDG_00270 1.6e-205 yacL S domain protein
HKDCBFDG_00271 9.6e-291 gltX 6.1.1.17, 6.1.1.24 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HKDCBFDG_00272 7.8e-100 ywlG S Belongs to the UPF0340 family
HKDCBFDG_00273 4.8e-268 cysS 6.1.1.16, 6.3.1.13 J Belongs to the class-I aminoacyl-tRNA synthetase family
HKDCBFDG_00274 2.1e-70 mrnC J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HKDCBFDG_00275 6.4e-134 rlmB 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HKDCBFDG_00276 2.9e-102 sigH K Belongs to the sigma-70 factor family
HKDCBFDG_00277 3.2e-21 rpmG J Belongs to the bacterial ribosomal protein bL33 family
HKDCBFDG_00278 2.4e-23 secE U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
HKDCBFDG_00279 5.9e-97 nusG K Participates in transcription elongation, termination and antitermination
HKDCBFDG_00280 2.2e-51 rplK J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HKDCBFDG_00281 7.4e-121 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
HKDCBFDG_00282 4.6e-244 steT E amino acid
HKDCBFDG_00283 3.2e-81 rplJ J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HKDCBFDG_00284 4.6e-53 rplL J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
HKDCBFDG_00285 2.8e-271 cydA 1.10.3.14 C ubiquinol oxidase
HKDCBFDG_00286 4.1e-176 cydB 1.10.3.14 C Cytochrome d ubiquinol oxidase subunit II
HKDCBFDG_00287 0.0 cydD CO ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydD
HKDCBFDG_00288 0.0 cydD CO ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HKDCBFDG_00289 0.0 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
HKDCBFDG_00290 1.5e-245 brnQ U Component of the transport system for branched-chain amino acids
HKDCBFDG_00291 1.9e-194 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HKDCBFDG_00292 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HKDCBFDG_00293 2e-35 nrdH O Glutaredoxin
HKDCBFDG_00294 4.9e-74 tadA 3.5.4.33 F Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
HKDCBFDG_00295 0.0 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HKDCBFDG_00296 4.9e-40 yaaK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HKDCBFDG_00297 3e-110 recR L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HKDCBFDG_00298 2.4e-21 S Protein of unknown function (DUF2508)
HKDCBFDG_00299 3e-116 tmk 2.7.4.9 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HKDCBFDG_00300 4e-53 yaaQ S Cyclic-di-AMP receptor
HKDCBFDG_00301 1.9e-192 holB 2.7.7.7 L DNA polymerase III
HKDCBFDG_00302 3.4e-55 yabA L Involved in initiation control of chromosome replication
HKDCBFDG_00303 8e-157 rsmI 2.1.1.198 H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HKDCBFDG_00304 1.3e-145 fat 3.1.2.21 I Acyl-ACP thioesterase
HKDCBFDG_00305 1.6e-282 ppx3 3.6.1.11, 3.6.1.40 FP exopolyphosphatase
HKDCBFDG_00306 0.0 ppk 2.7.4.1 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HKDCBFDG_00307 2.3e-173 ppx 3.6.1.11, 3.6.1.40 FP exopolyphosphatase
HKDCBFDG_00308 1.2e-191 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
HKDCBFDG_00309 3.7e-146 KT YcbB domain
HKDCBFDG_00310 1.9e-186 argF 2.1.3.3 E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HKDCBFDG_00311 7e-167 arcC 2.7.2.2 E Belongs to the carbamate kinase family
HKDCBFDG_00312 3.1e-239 arcA 3.5.3.6 E Arginine
HKDCBFDG_00313 2.7e-258 E Arginine ornithine antiporter
HKDCBFDG_00314 3.9e-220 yxjG 2.1.1.14 E methionine synthase, vitamin-B12 independent
HKDCBFDG_00315 6e-213 arcT 2.6.1.1 E Aminotransferase
HKDCBFDG_00316 3.2e-130 yeaZ 2.3.1.234 O Universal bacterial protein YeaZ
HKDCBFDG_00317 1.3e-110 rimI 2.3.1.128 K Ribosomal-protein-alanine acetyltransferase
HKDCBFDG_00318 9.8e-194 tsaD 2.3.1.234 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HKDCBFDG_00320 2.7e-76 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
HKDCBFDG_00321 8.7e-75 marR K Transcriptional regulator, MarR family
HKDCBFDG_00322 4.9e-171 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HKDCBFDG_00323 4.2e-34 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
HKDCBFDG_00324 1.3e-171 fabD 2.3.1.39 I Malonyl CoA-acyl carrier protein transacylase
HKDCBFDG_00325 2.7e-129 IQ reductase
HKDCBFDG_00326 6e-230 fabF 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
HKDCBFDG_00327 1.6e-63 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
HKDCBFDG_00328 1.3e-75 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
HKDCBFDG_00329 7.1e-264 accC 6.3.4.14, 6.4.1.2 I Acetyl-CoA carboxylase biotin carboxylase subunit
HKDCBFDG_00330 1.5e-160 accD 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HKDCBFDG_00331 3e-139 accA 2.1.3.15, 6.4.1.2 I alpha subunit
HKDCBFDG_00332 1.7e-134 fabI 1.3.1.10, 1.3.1.9 I Enoyl- acyl-carrier-protein reductase NADH
HKDCBFDG_00333 9.7e-92 bioY S BioY family
HKDCBFDG_00334 1.6e-174 birA 6.3.4.15 H Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
HKDCBFDG_00335 0.0 uup S ABC transporter, ATP-binding protein
HKDCBFDG_00336 1.6e-271 sufB O assembly protein SufB
HKDCBFDG_00337 6.4e-84 nifU C SUF system FeS assembly protein, NifU family
HKDCBFDG_00338 9.8e-233 sufS 2.8.1.7, 4.4.1.16 E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HKDCBFDG_00339 5.4e-242 sufD O FeS assembly protein SufD
HKDCBFDG_00340 8.5e-145 sufC O FeS assembly ATPase SufC
HKDCBFDG_00341 1.4e-33 feoA P FeoA domain
HKDCBFDG_00342 0.0 feoB P transporter of a GTP-driven Fe(2 ) uptake system
HKDCBFDG_00343 6.7e-23 S Virus attachment protein p12 family
HKDCBFDG_00344 7.8e-155 menA 2.5.1.74 H 1,4-dihydroxy-2-naphthoate
HKDCBFDG_00345 4e-176 hepT 2.5.1.30, 2.5.1.90 H Belongs to the FPP GGPP synthase family
HKDCBFDG_00346 7.4e-183 1.1.1.28 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HKDCBFDG_00347 2.1e-216 aspB E DegT/DnrJ/EryC1/StrS aminotransferase family
HKDCBFDG_00348 2.1e-88 aroK 1.1.1.25, 2.7.1.71, 4.2.1.10, 4.2.3.4 F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HKDCBFDG_00349 6.2e-194 tyrA 1.3.1.12, 1.3.1.43 E prephenate dehydrogenase
HKDCBFDG_00350 1.3e-235 aroA 1.3.1.12, 1.3.1.43, 2.5.1.19 E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
HKDCBFDG_00351 5e-104
HKDCBFDG_00352 1.9e-214 aroC 4.2.3.5 E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HKDCBFDG_00353 7.6e-13 pheA 1.3.1.12, 2.3.1.79, 4.2.1.51, 5.4.99.5 E Chorismate mutase type II
HKDCBFDG_00354 6.4e-213 ydiN G Major Facilitator Superfamily
HKDCBFDG_00355 6.7e-244 dtpT U amino acid peptide transporter
HKDCBFDG_00358 1.7e-153 S Sucrose-6F-phosphate phosphohydrolase
HKDCBFDG_00359 3.3e-158 1.6.5.2 GM NAD(P)H-binding
HKDCBFDG_00360 3e-156 S Alpha beta hydrolase
HKDCBFDG_00361 5.9e-237 lmrB EGP Major facilitator Superfamily
HKDCBFDG_00363 0.0 S Bacterial membrane protein YfhO
HKDCBFDG_00364 6.6e-12
HKDCBFDG_00365 1.4e-50
HKDCBFDG_00366 0.0 kup P Transport of potassium into the cell
HKDCBFDG_00368 3.9e-284 glpK 2.7.1.30 F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HKDCBFDG_00369 5.4e-26 dmpI 5.3.2.6 G Belongs to the 4-oxalocrotonate tautomerase family
HKDCBFDG_00370 0.0 yjbQ P TrkA C-terminal domain protein
HKDCBFDG_00371 1.7e-276 pipD E Dipeptidase
HKDCBFDG_00372 1.2e-158 S Alpha/beta hydrolase of unknown function (DUF915)
HKDCBFDG_00373 2.6e-239 pts13C G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HKDCBFDG_00374 5.4e-43 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HKDCBFDG_00375 1.6e-168 T Calcineurin-like phosphoesterase superfamily domain
HKDCBFDG_00376 1.2e-159 EGP Major facilitator Superfamily
HKDCBFDG_00377 5.8e-201 mdtG EGP Major facilitator Superfamily
HKDCBFDG_00378 3.6e-252 yhdP S Transporter associated domain
HKDCBFDG_00379 1.6e-214 naiP EGP Major facilitator Superfamily
HKDCBFDG_00380 9.9e-63 K LysR substrate binding domain protein
HKDCBFDG_00381 7.6e-216 E GDSL-like Lipase/Acylhydrolase family
HKDCBFDG_00382 2.3e-195 lplA 6.3.1.20 H Lipoate-protein ligase
HKDCBFDG_00383 3.1e-259 lpdA 1.8.1.4 C Dehydrogenase
HKDCBFDG_00384 2.5e-202 pdhC 2.3.1.12 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
HKDCBFDG_00385 5.8e-180 pdhB 1.2.4.1 C Transketolase, C-terminal domain protein
HKDCBFDG_00386 1.8e-182 pdhA 1.2.4.1, 1.2.4.4 C Dehydrogenase E1 component
HKDCBFDG_00387 2.8e-54 azlD E Branched-chain amino acid transport
HKDCBFDG_00388 7.8e-118 azlC E azaleucine resistance protein AzlC
HKDCBFDG_00389 4.6e-285 thrC 4.2.3.1 E Threonine synthase
HKDCBFDG_00390 3.5e-233 hom 1.1.1.3, 2.7.2.4 E homoserine dehydrogenase
HKDCBFDG_00391 8e-157 thrB 2.7.1.39 F Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
HKDCBFDG_00392 6.3e-224 amtB P ammonium transporter
HKDCBFDG_00393 7.9e-132 XK27_08845 S ABC transporter, ATP-binding protein
HKDCBFDG_00394 1e-138 XK27_08840 U Belongs to the binding-protein-dependent transport system permease family
HKDCBFDG_00395 7e-181 ABC-SBP S ABC transporter
HKDCBFDG_00396 3.4e-291 S ABC transporter, ATP-binding protein
HKDCBFDG_00397 1.8e-206 nrnB S DHHA1 domain
HKDCBFDG_00398 5.1e-110 M ErfK YbiS YcfS YnhG
HKDCBFDG_00399 1.4e-83 nrdI F NrdI Flavodoxin like
HKDCBFDG_00400 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HKDCBFDG_00401 1.8e-167 nrdF 1.17.4.1 F Ribonucleotide reductase, small chain
HKDCBFDG_00402 1.2e-182 1.17.4.1 F Ribonucleotide reductase, small chain
HKDCBFDG_00403 4.2e-274 S Uncharacterized protein conserved in bacteria (DUF2325)
HKDCBFDG_00404 2.3e-116 gph 3.1.3.18 S HAD hydrolase, family IA, variant
HKDCBFDG_00405 3.1e-178 3.4.11.5 E Releases the N-terminal proline from various substrates
HKDCBFDG_00406 0.0 pepX 3.4.14.11 E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline
HKDCBFDG_00407 1.1e-205 yfnA E Amino Acid
HKDCBFDG_00408 3.8e-72 apfA 2.7.7.72, 3.6.1.61 F Nudix hydrolase
HKDCBFDG_00409 6.3e-105 gmk2 2.7.4.8 F Guanylate kinase
HKDCBFDG_00410 2e-82 zur P Belongs to the Fur family
HKDCBFDG_00412 8.8e-170
HKDCBFDG_00413 1.8e-187 galM 5.1.3.3 G Catalyzes the interconversion of alpha and beta anomers of maltose
HKDCBFDG_00414 1.6e-91 K Transcriptional regulator (TetR family)
HKDCBFDG_00415 6.7e-202 V domain protein
HKDCBFDG_00416 3e-79
HKDCBFDG_00418 1.6e-185 ydaM M Glycosyl transferase family group 2
HKDCBFDG_00419 6.4e-122 G Glycosyl hydrolases family 8
HKDCBFDG_00420 4.2e-142 mnaA 5.1.3.14 M UDP-N-acetylglucosamine 2-epimerase
HKDCBFDG_00421 8.7e-107 1.1.1.28 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HKDCBFDG_00422 1.7e-105 L transposase, IS605 OrfB family
HKDCBFDG_00423 1.7e-52 tlpA2 L Transposase IS200 like
HKDCBFDG_00424 4.7e-296 ybeC E amino acid
HKDCBFDG_00425 1.2e-134 pnuC H nicotinamide mononucleotide transporter
HKDCBFDG_00426 5.7e-208 menC 4.2.1.113 H Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)
HKDCBFDG_00427 1e-229 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HKDCBFDG_00428 4.5e-120 pgm7 5.4.2.11, 5.4.2.12 G phosphoglycerate mutase
HKDCBFDG_00429 1.2e-115 dedA S SNARE associated Golgi protein
HKDCBFDG_00430 0.0 helD 3.6.4.12 L DNA helicase
HKDCBFDG_00431 7.3e-161 EG EamA-like transporter family
HKDCBFDG_00432 0.0 ltaS 2.7.8.20 M Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
HKDCBFDG_00433 3.4e-135 IQ Dehydrogenase reductase
HKDCBFDG_00434 2.3e-104 2.3.1.128 K acetyltransferase
HKDCBFDG_00435 5.3e-175 coaA 2.7.1.33 F Pantothenic acid kinase
HKDCBFDG_00436 1.9e-130 sptS 2.7.13.3 T Histidine kinase
HKDCBFDG_00437 8e-80 K response regulator
HKDCBFDG_00438 8.6e-113 2.7.6.5 T Region found in RelA / SpoT proteins
HKDCBFDG_00439 7e-49 mscL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
HKDCBFDG_00440 1.5e-219 lysP E amino acid
HKDCBFDG_00441 0.0 asnB 6.3.5.4 E Asparagine synthase
HKDCBFDG_00442 8.9e-292 murE 6.3.2.13, 6.3.2.7 M Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HKDCBFDG_00443 5.3e-292 murE 6.3.2.13, 6.3.2.7 M Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HKDCBFDG_00444 1.6e-111 lepB 3.4.21.89 U Belongs to the peptidase S26 family
HKDCBFDG_00445 5.5e-161 F DNA/RNA non-specific endonuclease
HKDCBFDG_00446 1.5e-69 L nuclease
HKDCBFDG_00447 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HKDCBFDG_00448 2.1e-20
HKDCBFDG_00449 3.6e-280 mntH P H( )-stimulated, divalent metal cation uptake system
HKDCBFDG_00450 1.6e-188 tdh 1.1.1.14 E Alcohol dehydrogenase GroES-like domain
HKDCBFDG_00451 1.1e-107 ygfC K Bacterial regulatory proteins, tetR family
HKDCBFDG_00452 1.6e-26 hrtB V ABC transporter permease
HKDCBFDG_00453 1.5e-117 hrtB V ABC transporter permease
HKDCBFDG_00454 5.5e-124 devA 3.6.3.25 V ABC transporter, ATP-binding protein
HKDCBFDG_00455 1.8e-75 argR K Regulates arginine biosynthesis genes
HKDCBFDG_00456 2.6e-46 czrA K Transcriptional regulator, ArsR family
HKDCBFDG_00457 7.2e-167 acm2 3.2.1.17 NU Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
HKDCBFDG_00458 2e-169 scrR K Transcriptional regulator, LacI family
HKDCBFDG_00459 9.5e-26
HKDCBFDG_00460 4.1e-102
HKDCBFDG_00461 1e-96 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HKDCBFDG_00462 2.2e-108 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX
HKDCBFDG_00463 4.3e-55
HKDCBFDG_00464 8.2e-125 yrkL S Flavodoxin-like fold
HKDCBFDG_00466 1.5e-64 yeaO S Protein of unknown function, DUF488
HKDCBFDG_00467 5e-116 mpg 3.2.2.21 L Belongs to the DNA glycosylase MPG family
HKDCBFDG_00468 1.9e-206 3.1.3.1 S associated with various cellular activities
HKDCBFDG_00469 1.7e-213 S Putative metallopeptidase domain
HKDCBFDG_00470 2.5e-46
HKDCBFDG_00471 1.8e-229 pbuG S permease
HKDCBFDG_00472 0.0 pepO 3.4.24.71 O Peptidase family M13
HKDCBFDG_00473 1.2e-91 ymdB S Macro domain protein
HKDCBFDG_00474 6.9e-147 pnuC H nicotinamide mononucleotide transporter
HKDCBFDG_00475 1.7e-79 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
HKDCBFDG_00476 1.4e-170 MA20_03535 1.1.1.399, 1.1.1.95 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HKDCBFDG_00477 5.9e-52
HKDCBFDG_00478 5.7e-141 tcyA ET Belongs to the bacterial solute-binding protein 3 family
HKDCBFDG_00479 5.3e-119 tcyB U Binding-protein-dependent transport system inner membrane component
HKDCBFDG_00480 6.6e-136 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
HKDCBFDG_00481 6.9e-36
HKDCBFDG_00482 2.7e-96 yxkA S Phosphatidylethanolamine-binding protein
HKDCBFDG_00483 6e-143 ptp3 3.1.3.48 T Tyrosine phosphatase family
HKDCBFDG_00484 4.2e-183 celE 3.2.1.4 GH5,GH9 E GDSL-like Lipase/Acylhydrolase family
HKDCBFDG_00485 1e-223 galK 2.7.1.6 F Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HKDCBFDG_00486 2.4e-286 galT 2.7.7.12 G UDP-glucose--hexose-1-phosphate uridylyltransferase
HKDCBFDG_00487 2.1e-180 galR K Transcriptional regulator
HKDCBFDG_00488 0.0 rafA 3.2.1.22 G alpha-galactosidase
HKDCBFDG_00489 1.9e-275 lacS G Transporter
HKDCBFDG_00490 5.3e-212 norA EGP Major facilitator Superfamily
HKDCBFDG_00491 1.8e-161 yunF F Protein of unknown function DUF72
HKDCBFDG_00492 0.0 metG 6.1.1.10 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HKDCBFDG_00493 2.2e-145 tatD L hydrolase, TatD family
HKDCBFDG_00494 5.6e-98 rnmV 3.1.26.8 J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HKDCBFDG_00495 1.8e-159 ksgA 2.1.1.182 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
HKDCBFDG_00496 1.3e-159 ispE 2.1.1.182, 2.7.1.148 F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HKDCBFDG_00497 4.2e-164 znuA P Belongs to the bacterial solute-binding protein 9 family
HKDCBFDG_00498 1e-93 fhuC P ABC transporter
HKDCBFDG_00499 7.2e-128 znuB U ABC 3 transport family
HKDCBFDG_00500 1.4e-150 purR 2.4.2.22, 2.4.2.7 F pur operon repressor
HKDCBFDG_00501 2.4e-203 glmU 2.3.1.157, 2.7.7.23 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HKDCBFDG_00502 8.8e-176 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HKDCBFDG_00503 1.2e-31
HKDCBFDG_00504 1.2e-141 yxeH S hydrolase
HKDCBFDG_00505 1.6e-265 ywfO S HD domain protein
HKDCBFDG_00506 3.2e-74 ywiB S Domain of unknown function (DUF1934)
HKDCBFDG_00507 2.1e-47 rpoE K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
HKDCBFDG_00508 4.4e-311 pyrG 6.3.4.2 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
HKDCBFDG_00509 5.2e-237 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HKDCBFDG_00510 6e-41 rpmE2 J Ribosomal protein L31
HKDCBFDG_00511 4.2e-52 mdtG EGP Major facilitator Superfamily
HKDCBFDG_00512 4.7e-123 srtA 3.4.22.70 M sortase family
HKDCBFDG_00513 6.2e-47 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HKDCBFDG_00514 2.5e-87 lemA S LemA family
HKDCBFDG_00515 1.4e-156 htpX O Belongs to the peptidase M48B family
HKDCBFDG_00516 7.5e-258 murF 6.3.2.10, 6.3.2.13 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
HKDCBFDG_00517 1.9e-251 cshA 3.6.4.13 F DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
HKDCBFDG_00518 2.9e-60 acpS 2.7.6.3, 2.7.8.7, 5.1.1.1 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
HKDCBFDG_00519 7.6e-208 alr 5.1.1.1 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HKDCBFDG_00520 4.3e-56 L Toxic component of a toxin-antitoxin (TA) module
HKDCBFDG_00521 1.2e-112 S (CBS) domain
HKDCBFDG_00522 9.6e-103 pth 3.1.1.29 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
HKDCBFDG_00523 0.0 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HKDCBFDG_00524 1.6e-39 yabO J S4 domain protein
HKDCBFDG_00525 1.5e-56 divIC D Septum formation initiator
HKDCBFDG_00526 3e-87 yabR J RNA binding
HKDCBFDG_00527 4.2e-253 tilS 2.4.2.8, 6.3.4.19 J Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
HKDCBFDG_00528 5e-96 hpt 2.4.2.8 F Belongs to the purine pyrimidine phosphoribosyltransferase family
HKDCBFDG_00529 0.0 ftsH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HKDCBFDG_00530 1.1e-161 hslO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HKDCBFDG_00531 5.4e-189 dus J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HKDCBFDG_00532 2.6e-288 lysS 6.1.1.6 J Belongs to the class-II aminoacyl-tRNA synthetase family
HKDCBFDG_00533 3.2e-13
HKDCBFDG_00534 1.4e-234 L Transposase
HKDCBFDG_00538 1.3e-102 clpP 3.4.21.92 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
HKDCBFDG_00539 2.5e-118 tenA 3.5.99.2 K Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HKDCBFDG_00540 4.2e-167 whiA K May be required for sporulation
HKDCBFDG_00541 4.9e-187 ybhK S Required for morphogenesis under gluconeogenic growth conditions
HKDCBFDG_00542 2.3e-159 rapZ S Displays ATPase and GTPase activities
HKDCBFDG_00543 2.2e-204
HKDCBFDG_00544 0.0 uvrA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
HKDCBFDG_00545 0.0 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
HKDCBFDG_00547 8.9e-113 yfbR S HD containing hydrolase-like enzyme
HKDCBFDG_00548 0.0 pgm 5.4.2.2, 5.4.2.8 G Phosphoglucomutase phosphomannomutase, alpha beta alpha domain
HKDCBFDG_00549 2e-135 cof S haloacid dehalogenase-like hydrolase
HKDCBFDG_00550 5.6e-172 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
HKDCBFDG_00551 3.8e-198 ilvE 2.6.1.42 E Branched-chain amino acid aminotransferase
HKDCBFDG_00552 4.4e-169 cysK 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
HKDCBFDG_00553 1.5e-152 metAA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to
HKDCBFDG_00554 1.7e-131 trxB 1.8.1.9 C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
HKDCBFDG_00555 1.5e-76 yphH S Cupin domain
HKDCBFDG_00556 5.8e-188 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HKDCBFDG_00557 6.5e-226 mtnE 2.6.1.83 E Aminotransferase
HKDCBFDG_00558 2.3e-147 mtnU 3.5.1.3 S Carbon-nitrogen hydrolase
HKDCBFDG_00559 2.1e-171 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
HKDCBFDG_00560 5.3e-184 gpsA 1.1.1.94 I Glycerol-3-phosphate dehydrogenase
HKDCBFDG_00561 4.7e-162 lgt 2.1.1.199 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HKDCBFDG_00562 1e-176 hprK F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HKDCBFDG_00563 1.2e-47 yvlD S Mycobacterial 4 TMS phage holin, superfamily IV
HKDCBFDG_00564 4.1e-53 KT PspC domain protein
HKDCBFDG_00565 4.5e-202 prfB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HKDCBFDG_00566 0.0 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
HKDCBFDG_00567 6.5e-96 hpf J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HKDCBFDG_00568 3.6e-128 comFC S Competence protein
HKDCBFDG_00569 1.8e-248 comFA L Helicase C-terminal domain protein
HKDCBFDG_00570 2.6e-112 yvyE 3.4.13.9 S YigZ family
HKDCBFDG_00571 6.4e-38
HKDCBFDG_00572 0.0 ydaO E amino acid
HKDCBFDG_00573 2.6e-289 groL O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
HKDCBFDG_00574 8.1e-42 groS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HKDCBFDG_00575 1.7e-114 rex K Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HKDCBFDG_00578 2e-31 M LysM domain
HKDCBFDG_00579 6.8e-204 glxK 2.7.1.165 G Belongs to the glycerate kinase type-1 family
HKDCBFDG_00580 4.2e-210 EG GntP family permease
HKDCBFDG_00581 4.7e-227 thiI 2.8.1.4 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HKDCBFDG_00582 3.3e-214 iscS2 2.8.1.7 E Aminotransferase class V
HKDCBFDG_00583 6.4e-307 ezrA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HKDCBFDG_00584 1.7e-108 rpsD J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HKDCBFDG_00586 7.1e-26 S YjcQ protein
HKDCBFDG_00587 6.7e-148 S Uncharacterised 5xTM membrane BCR, YitT family COG1284
HKDCBFDG_00588 1.7e-131 S Membrane
HKDCBFDG_00589 1.3e-75 4.4.1.5 E Glyoxalase
HKDCBFDG_00590 4.5e-85 yueI S Protein of unknown function (DUF1694)
HKDCBFDG_00591 7.1e-234 rarA L recombination factor protein RarA
HKDCBFDG_00593 2.3e-81 usp6 T universal stress protein
HKDCBFDG_00594 1.3e-157 2.3.1.19 K Helix-turn-helix XRE-family like proteins
HKDCBFDG_00595 5.5e-214 ddl 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
HKDCBFDG_00596 8.4e-179 S Protein of unknown function (DUF2785)
HKDCBFDG_00598 3.8e-221 rodA D Belongs to the SEDS family
HKDCBFDG_00599 7.9e-32 S Protein of unknown function (DUF2969)
HKDCBFDG_00600 1e-182 mbl D Cell shape determining protein MreB Mrl
HKDCBFDG_00601 4.7e-219 murA 2.5.1.7 M EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
HKDCBFDG_00602 2.8e-29 S Protein of unknown function (DUF1146)
HKDCBFDG_00603 6.4e-67 atpC C Produces ATP from ADP in the presence of a proton gradient across the membrane
HKDCBFDG_00604 4.4e-253 atpD 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HKDCBFDG_00605 2.3e-165 atpG C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HKDCBFDG_00606 4.7e-285 atpA 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HKDCBFDG_00607 2.8e-91 atpH C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HKDCBFDG_00608 3.7e-53 atpF C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HKDCBFDG_00609 1.2e-16 atpE C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HKDCBFDG_00610 5.8e-129 atpB C it plays a direct role in the translocation of protons across the membrane
HKDCBFDG_00611 5.4e-218 pyrP F Permease
HKDCBFDG_00612 3.6e-124 yibF S overlaps another CDS with the same product name
HKDCBFDG_00613 3.5e-181 yibE S overlaps another CDS with the same product name
HKDCBFDG_00614 1.2e-114 upp 2.4.2.9 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HKDCBFDG_00615 4.6e-230 glyA 2.1.2.1 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HKDCBFDG_00616 2.8e-193 ywlC 2.7.7.87, 3.1.3.48 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
HKDCBFDG_00617 5.1e-156 prmB 2.1.1.297, 2.1.1.298 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
HKDCBFDG_00618 1.2e-154 prfA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HKDCBFDG_00619 1.6e-108 tdk 2.7.1.21 F thymidine kinase
HKDCBFDG_00620 1.9e-261 murF 6.3.2.10, 6.3.2.13 M Domain of unknown function (DUF1727)
HKDCBFDG_00621 3.4e-140 cobQ S CobB/CobQ-like glutamine amidotransferase domain
HKDCBFDG_00622 2.8e-48
HKDCBFDG_00623 6.4e-137 L Transposase and inactivated derivatives, IS30 family
HKDCBFDG_00624 8.3e-24 L Plasmid pRiA4b ORF-3-like protein
HKDCBFDG_00625 1e-15
HKDCBFDG_00626 1e-190 gap 1.2.1.12 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
HKDCBFDG_00627 6.6e-226 pgk 2.7.2.3, 5.3.1.1 F Belongs to the phosphoglycerate kinase family
HKDCBFDG_00628 3.1e-144 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
HKDCBFDG_00629 1.2e-247 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
HKDCBFDG_00630 1.3e-252 yifK E Amino acid permease
HKDCBFDG_00631 4.2e-289 clcA P chloride
HKDCBFDG_00632 4.5e-33 secG U Preprotein translocase
HKDCBFDG_00633 0.0 rnr J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
HKDCBFDG_00634 2.9e-84 smpB J the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
HKDCBFDG_00635 5.5e-109 yxjI
HKDCBFDG_00636 2.4e-135 ung 3.2.2.27 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HKDCBFDG_00637 2.4e-178 pta 2.3.1.8, 3.6.3.21 C phosphate acetyltransferase
HKDCBFDG_00638 2.9e-81 ydiB 2.7.1.221, 5.1.1.1 O Hydrolase, P-loop family
HKDCBFDG_00639 3.3e-89 K Acetyltransferase (GNAT) domain
HKDCBFDG_00640 1.3e-101 dnaQ 2.7.7.7 L DNA polymerase III
HKDCBFDG_00641 5.7e-166 murB 1.3.1.98 M Cell wall formation
HKDCBFDG_00642 2.3e-148 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HKDCBFDG_00643 9.1e-116 ybbR S YbbR-like protein
HKDCBFDG_00644 2.5e-253 glmM 5.4.2.10 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HKDCBFDG_00645 0.0 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
HKDCBFDG_00646 3.3e-52
HKDCBFDG_00647 2.1e-210 oatA I Acyltransferase
HKDCBFDG_00648 2.2e-148 XK27_02985 S Sucrose-6F-phosphate phosphohydrolase
HKDCBFDG_00649 2.4e-75 lytE M Lysin motif
HKDCBFDG_00650 9.2e-160 MA20_14895 S Conserved hypothetical protein 698
HKDCBFDG_00651 1.3e-162 K LysR substrate binding domain
HKDCBFDG_00652 2.2e-131 manA 5.3.1.8 G mannose-6-phosphate isomerase
HKDCBFDG_00653 4.4e-144 yitS S EDD domain protein, DegV family
HKDCBFDG_00654 7.2e-89 racA K Domain of unknown function (DUF1836)
HKDCBFDG_00655 1.9e-180 yfeX P Peroxidase
HKDCBFDG_00656 5.3e-181 manL 2.7.1.191 G PTS system sorbose subfamily IIB component
HKDCBFDG_00657 2.7e-122 manY G PTS system
HKDCBFDG_00658 3.9e-170 manN G system, mannose fructose sorbose family IID component
HKDCBFDG_00659 3.9e-56 S Domain of unknown function (DUF956)
HKDCBFDG_00661 6.4e-131 K response regulator
HKDCBFDG_00662 2.2e-250 yclK 2.7.13.3 T Histidine kinase
HKDCBFDG_00663 2.5e-150 glcU U sugar transport
HKDCBFDG_00664 0.0 dxs 2.2.1.7 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HKDCBFDG_00666 1.1e-253 yifK E Amino acid permease
HKDCBFDG_00668 2.2e-265 pipD E Dipeptidase
HKDCBFDG_00669 4.5e-163 endA F DNA RNA non-specific endonuclease
HKDCBFDG_00670 7.7e-163 fadB4 1.1.1.157 I 3-hydroxyacyl-CoA dehydrogenase
HKDCBFDG_00671 0.0 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HKDCBFDG_00672 2.1e-149 S Alpha/beta hydrolase of unknown function (DUF915)
HKDCBFDG_00674 4.3e-225
HKDCBFDG_00675 3e-190 V Beta-lactamase
HKDCBFDG_00676 9.2e-89 pgpA 3.1.3.27 I Phosphatidylglycerophosphatase A
HKDCBFDG_00677 5.7e-44 S membrane transporter protein
HKDCBFDG_00678 2.2e-54 S membrane transporter protein
HKDCBFDG_00679 5.8e-176 S AI-2E family transporter
HKDCBFDG_00680 3.7e-213 phbA 2.3.1.9 I Belongs to the thiolase family
HKDCBFDG_00681 4.2e-158 rssA S Phospholipase, patatin family
HKDCBFDG_00682 1.1e-141 K LysR substrate binding domain
HKDCBFDG_00683 1.3e-11 K LysR substrate binding domain
HKDCBFDG_00684 0.0 1.3.5.4 C FAD binding domain
HKDCBFDG_00685 1.3e-70 S Domain of unknown function (DUF4352)
HKDCBFDG_00686 2e-113 yicL EG EamA-like transporter family
HKDCBFDG_00687 2.4e-62
HKDCBFDG_00689 1e-31
HKDCBFDG_00690 1.6e-67 S pyridoxamine 5-phosphate
HKDCBFDG_00691 2.6e-177 yobV1 K WYL domain
HKDCBFDG_00692 2.1e-244 XK27_08635 S UPF0210 protein
HKDCBFDG_00693 2.5e-40 gcvR T Belongs to the UPF0237 family
HKDCBFDG_00694 1.3e-168 mccA 2.5.1.134, 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
HKDCBFDG_00695 2.3e-212 metC 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
HKDCBFDG_00696 8.3e-204 adh 1.1.1.1, 1.1.1.14 C Zinc-binding dehydrogenase
HKDCBFDG_00697 4.6e-236 F Permease
HKDCBFDG_00698 1.7e-159 sufD O Uncharacterized protein family (UPF0051)
HKDCBFDG_00699 5.3e-112 nrdG 1.97.1.4 O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HKDCBFDG_00700 0.0 nrdD 1.1.98.6 F Ribonucleoside-triphosphate reductase
HKDCBFDG_00701 2e-110 XK27_05795 P ABC transporter permease
HKDCBFDG_00702 2.4e-142 ET Bacterial periplasmic substrate-binding proteins
HKDCBFDG_00704 1.4e-76 M Core-2/I-Branching enzyme
HKDCBFDG_00705 4.6e-87 M transferase activity, transferring glycosyl groups
HKDCBFDG_00706 8.8e-69 cps3F
HKDCBFDG_00707 1.9e-67 M Domain of unknown function (DUF4422)
HKDCBFDG_00708 3.3e-35 M biosynthesis protein
HKDCBFDG_00709 3.9e-147 cps1D M Domain of unknown function (DUF4422)
HKDCBFDG_00710 1.1e-118 rfbP M Bacterial sugar transferase
HKDCBFDG_00711 4.2e-147 recX 2.4.1.337 GT4 S Regulatory protein RecX
HKDCBFDG_00712 1.3e-07
HKDCBFDG_00713 3.8e-31 S Protein of unknown function (DUF2922)
HKDCBFDG_00714 8.6e-138 yihY S Belongs to the UPF0761 family
HKDCBFDG_00715 0.0 XK27_08315 M Sulfatase
HKDCBFDG_00716 1.7e-167 map 3.4.11.18 E Methionine Aminopeptidase
HKDCBFDG_00717 8.5e-78 fld C Flavodoxin
HKDCBFDG_00718 3e-75 gtcA S Teichoic acid glycosylation protein
HKDCBFDG_00720 8.9e-232 yfmL 3.6.4.13 L DEAD DEAH box helicase
HKDCBFDG_00721 1.3e-190 mocA S Oxidoreductase
HKDCBFDG_00722 4.9e-63 S Domain of unknown function (DUF4828)
HKDCBFDG_00723 4.9e-102 yvdD 3.2.2.10 S Belongs to the LOG family
HKDCBFDG_00724 7.6e-158 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
HKDCBFDG_00725 2.5e-286 gshF 6.3.2.2 H Belongs to the glutamate--cysteine ligase type 1 family
HKDCBFDG_00726 1.3e-137 S NADPH-dependent FMN reductase
HKDCBFDG_00727 2.3e-33 yneR S Belongs to the HesB IscA family
HKDCBFDG_00728 2.4e-303 ybiT S ABC transporter, ATP-binding protein
HKDCBFDG_00729 1.7e-84 dps P Belongs to the Dps family
HKDCBFDG_00730 2.7e-105
HKDCBFDG_00731 3.9e-184 brpA K Cell envelope-like function transcriptional attenuator common domain protein
HKDCBFDG_00732 1.4e-101 K helix_turn_helix multiple antibiotic resistance protein
HKDCBFDG_00733 3.7e-62 fsr EGP Major Facilitator Superfamily
HKDCBFDG_00734 4.7e-47 fsr EGP Major Facilitator Superfamily
HKDCBFDG_00735 2.1e-96 ogt 2.1.1.63, 3.2.2.20 L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HKDCBFDG_00736 1.1e-15 S CAAX protease self-immunity
HKDCBFDG_00737 5.6e-71 S CAAX protease self-immunity
HKDCBFDG_00739 4.6e-89 Q Methyltransferase domain
HKDCBFDG_00740 3.3e-14 Q Methyltransferase domain
HKDCBFDG_00741 3.3e-84 1.5.1.40 S NADP oxidoreductase coenzyme F420-dependent
HKDCBFDG_00742 1.6e-49 K 2 iron, 2 sulfur cluster binding
HKDCBFDG_00743 0.0 mco Q Multicopper oxidase
HKDCBFDG_00744 1.4e-89 S Aminoacyl-tRNA editing domain
HKDCBFDG_00745 3.1e-75 ddaH 3.5.3.18 E Amidinotransferase
HKDCBFDG_00747 1.7e-193 nhaC C Na H antiporter NhaC
HKDCBFDG_00748 3.2e-144 S Oxidoreductase family, NAD-binding Rossmann fold
HKDCBFDG_00750 9.8e-288 zwf 1.1.1.363, 1.1.1.49 G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HKDCBFDG_00751 9.7e-206 yeaN P Transporter, major facilitator family protein
HKDCBFDG_00752 6.5e-75 S 3-demethylubiquinone-9 3-methyltransferase
HKDCBFDG_00753 2.4e-83 nrdI F Belongs to the NrdI family
HKDCBFDG_00754 6.9e-251 yhdP S Transporter associated domain
HKDCBFDG_00755 8.1e-88 GM epimerase
HKDCBFDG_00756 1.3e-85 M1-874 K Domain of unknown function (DUF1836)
HKDCBFDG_00757 9.8e-157 3.2.1.52 GH20 G Xylose isomerase domain protein TIM barrel
HKDCBFDG_00758 1.7e-265 pipD E Dipeptidase
HKDCBFDG_00759 3.2e-130
HKDCBFDG_00760 7.1e-89 ybaK J Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HKDCBFDG_00761 7e-130 gntR K UbiC transcription regulator-associated domain protein
HKDCBFDG_00762 2.4e-147 ybjI 3.1.3.102, 3.1.3.104, 3.1.3.23 S haloacid dehalogenase-like hydrolase
HKDCBFDG_00763 0.0 xfp 4.1.2.22, 4.1.2.9 G Phosphoketolase
HKDCBFDG_00764 7.6e-280 yjeM E Amino Acid
HKDCBFDG_00765 4.2e-141 K helix_turn _helix lactose operon repressor
HKDCBFDG_00766 1.3e-155 gyaR 1.1.1.26, 2.7.1.165 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HKDCBFDG_00767 6.3e-161
HKDCBFDG_00768 1.1e-196 2.7.1.53 G Xylulose kinase
HKDCBFDG_00769 7e-140 ulaE 5.1.3.22 G Xylose isomerase-like TIM barrel
HKDCBFDG_00770 1.5e-135 araD 4.1.2.17, 5.1.3.4 G links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source
HKDCBFDG_00771 2.8e-57 kguE 2.7.1.45 G Xylose isomerase domain protein TIM barrel
HKDCBFDG_00772 1.3e-239 G PTS system Galactitol-specific IIC component
HKDCBFDG_00773 2.4e-149 S Amidohydrolase
HKDCBFDG_00774 3.2e-64 G Domain of unknown function (DUF386)
HKDCBFDG_00775 3.5e-185 G Sugar (and other) transporter
HKDCBFDG_00776 2.4e-62 G Domain of unknown function (DUF386)
HKDCBFDG_00777 2.3e-51 S helix_turn_helix, Deoxyribose operon repressor
HKDCBFDG_00778 2.9e-41
HKDCBFDG_00779 2.9e-180 ulaG S Beta-lactamase superfamily domain
HKDCBFDG_00780 1.7e-60 cmtB 2.7.1.194, 2.7.1.197, 2.7.1.200, 2.7.1.202 G Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HKDCBFDG_00781 2e-219 ulaA S PTS system sugar-specific permease component
HKDCBFDG_00782 3.3e-25 sgaB 2.7.1.194 G PTS system, Lactose/Cellobiose specific IIB subunit
HKDCBFDG_00783 1.9e-91 ulaD 4.1.1.85, 4.1.2.43 G Orotidine 5'-phosphate decarboxylase / HUMPS family
HKDCBFDG_00784 1.6e-53 L haloacid dehalogenase-like hydrolase
HKDCBFDG_00785 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HKDCBFDG_00786 1.9e-250 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
HKDCBFDG_00787 2.5e-115 radC L DNA repair protein
HKDCBFDG_00788 1.9e-181 mreB D cell shape determining protein MreB
HKDCBFDG_00789 3.1e-145 mreC M Involved in formation and maintenance of cell shape
HKDCBFDG_00790 6.6e-93 mreD M rod shape-determining protein MreD
HKDCBFDG_00791 1.4e-108 glnP P ABC transporter permease
HKDCBFDG_00792 4.8e-114 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
HKDCBFDG_00793 1.5e-160 aatB ET ABC transporter substrate-binding protein
HKDCBFDG_00794 2.1e-230 ymfF S Peptidase M16 inactive domain protein
HKDCBFDG_00795 8.4e-251 ymfH S Peptidase M16
HKDCBFDG_00796 1.8e-96 ymfM S Helix-turn-helix domain
HKDCBFDG_00797 1.1e-98 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HKDCBFDG_00798 1.6e-230 cinA 3.5.1.42 S Belongs to the CinA family
HKDCBFDG_00799 1.2e-191 recA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HKDCBFDG_00800 4.1e-204 rny S Endoribonuclease that initiates mRNA decay
HKDCBFDG_00801 0.0 mutS L that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HKDCBFDG_00802 0.0 mutL L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HKDCBFDG_00803 9.4e-104 ruvA 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
HKDCBFDG_00804 2.9e-190 ruvB 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
HKDCBFDG_00805 7e-175 2.4.2.29 F queuine tRNA-ribosyltransferase activity
HKDCBFDG_00806 1.2e-41 yajC U Preprotein translocase
HKDCBFDG_00807 4.7e-180 nrnA 3.1.13.3, 3.1.3.7 S DHHA1 domain protein
HKDCBFDG_00808 9.3e-232 cshB 3.6.4.13 JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
HKDCBFDG_00809 0.0 alaS 6.1.1.7 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HKDCBFDG_00810 1.2e-42 yrzL S Belongs to the UPF0297 family
HKDCBFDG_00811 8.1e-73 yqgF J Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HKDCBFDG_00812 5.7e-33 yrzB S Belongs to the UPF0473 family
HKDCBFDG_00813 1.3e-162 rnhC 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HKDCBFDG_00814 4.7e-91 cvpA S Colicin V production protein
HKDCBFDG_00815 0.0 mutS2 L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
HKDCBFDG_00816 5.1e-53 trxA O Belongs to the thioredoxin family
HKDCBFDG_00817 1.2e-225 clcA_2 P Chloride transporter, ClC family
HKDCBFDG_00818 7.2e-95 yslB S Protein of unknown function (DUF2507)
HKDCBFDG_00819 1.2e-146 murI 3.6.1.66, 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
HKDCBFDG_00820 1.1e-107 rdgB 3.6.1.66, 5.1.1.3 F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HKDCBFDG_00821 8.8e-95 S Phosphoesterase
HKDCBFDG_00822 3.4e-129 K response regulator
HKDCBFDG_00823 0.0 vicK 2.7.13.3 T Histidine kinase
HKDCBFDG_00824 5.8e-236 yycH S YycH protein
HKDCBFDG_00825 1.5e-141 yycI S YycH protein
HKDCBFDG_00826 1.1e-152 vicX 3.1.26.11 S domain protein
HKDCBFDG_00827 1.6e-206 htrA 3.4.21.107 O serine protease
HKDCBFDG_00828 4.4e-80 rlmH 2.1.1.177 J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HKDCBFDG_00829 1.3e-70 K Transcriptional regulator
HKDCBFDG_00830 1.1e-175 malR K Transcriptional regulator, LacI family
HKDCBFDG_00831 5.1e-251 malT G Major Facilitator
HKDCBFDG_00832 0.0 mapA 2.4.1.8 GH65 G hydrolase, family 65, central catalytic
HKDCBFDG_00833 9.1e-116 pgmB 2.4.1.64, 3.1.3.12, 3.2.1.28, 5.4.2.6 GH37,GH65 S beta-phosphoglucomutase
HKDCBFDG_00834 7.7e-43 ysdA CP transmembrane transport
HKDCBFDG_00835 5.5e-54 ysdA CP transmembrane transport
HKDCBFDG_00836 6.2e-190 pacA 3.5.1.24 M Linear amide C-N hydrolase, choloylglycine hydrolase family protein
HKDCBFDG_00837 2.1e-182 D Alpha beta
HKDCBFDG_00838 3.1e-181 ldhD 1.1.1.28 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HKDCBFDG_00839 1.8e-215 patA 2.6.1.1 E Aminotransferase
HKDCBFDG_00840 1e-34
HKDCBFDG_00841 0.0 clpL O associated with various cellular activities
HKDCBFDG_00842 2.4e-278 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HKDCBFDG_00843 0.0 rexB 3.1.21.3, 3.6.4.12 L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' - 3' nuclease activity
HKDCBFDG_00844 0.0 addA 3.6.4.12 L ATP-dependent helicase nuclease subunit A
HKDCBFDG_00845 2.6e-163 yvgN C Aldo keto reductase
HKDCBFDG_00846 1.8e-287 glpQ 3.1.4.46 C phosphodiesterase
HKDCBFDG_00847 2.7e-224 dhaT 1.1.1.1, 1.1.1.202 C Dehydrogenase
HKDCBFDG_00849 8.7e-08
HKDCBFDG_00850 4e-49 uvrX 2.7.7.7 L Belongs to the DNA polymerase type-Y family
HKDCBFDG_00851 8.6e-60
HKDCBFDG_00852 5.6e-189 hrcA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
HKDCBFDG_00853 1.1e-59 grpE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HKDCBFDG_00854 0.0 dnaK O Heat shock 70 kDa protein
HKDCBFDG_00855 8.7e-175 dnaJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
HKDCBFDG_00856 1.1e-37 hisH E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HKDCBFDG_00857 2.3e-27 hisH E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HKDCBFDG_00859 4.9e-39 hisF 3.5.4.19, 3.6.1.31 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
HKDCBFDG_00860 1.3e-167 hisK 3.1.3.15 E Histidinol phosphate phosphatase, HisJ
HKDCBFDG_00861 4.8e-105 hisZ 2.4.2.17, 6.1.1.21 E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HKDCBFDG_00862 6.6e-78 hisZ 2.4.2.17, 6.1.1.21 E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HKDCBFDG_00863 5.8e-109 hisG 2.4.2.17 F Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
HKDCBFDG_00864 8.9e-229 hisD 1.1.1.23, 1.1.1.308 E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HKDCBFDG_00865 7.2e-101 hisB 1.1.1.23, 2.6.1.9, 3.1.3.15, 4.2.1.19 E imidazoleglycerol-phosphate dehydratase
HKDCBFDG_00866 1.2e-111 hisH E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HKDCBFDG_00867 1.6e-129 hisA 5.3.1.16 E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HKDCBFDG_00868 1.9e-141 hisF 3.5.4.19, 3.6.1.31 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
HKDCBFDG_00869 4.2e-55 hisI 3.5.4.19, 3.5.4.25, 3.6.1.31, 5.3.1.16 E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HKDCBFDG_00870 9.9e-52 hisE 3.5.4.19, 3.6.1.31, 5.3.1.16 E phosphoribosyl-ATP diphosphatase activity
HKDCBFDG_00871 4.3e-200 hisC 2.6.1.9 E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HKDCBFDG_00872 0.0 lepA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
HKDCBFDG_00873 1.9e-09
HKDCBFDG_00874 3.1e-110 3.1.3.73 G phosphoglycerate mutase
HKDCBFDG_00875 1.2e-111 C aldo keto reductase
HKDCBFDG_00876 1e-201 serC 2.6.1.52 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HKDCBFDG_00877 1.1e-220 serA 1.1.1.399, 1.1.1.95 EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HKDCBFDG_00878 3.5e-268 K COG COG0846 NAD-dependent protein deacetylases, SIR2 family
HKDCBFDG_00879 7.9e-79 K 2 iron, 2 sulfur cluster binding
HKDCBFDG_00880 8.7e-81 ribH 2.5.1.78 H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
HKDCBFDG_00881 1.3e-226 ribBA 3.5.4.25, 4.1.99.12 H Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate
HKDCBFDG_00882 8.3e-108 ribE 2.5.1.9, 3.5.4.25, 4.1.99.12 H Riboflavin synthase
HKDCBFDG_00883 1.4e-200 ribD 1.1.1.193, 3.5.4.26 H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HKDCBFDG_00884 2.5e-54 C FMN binding
HKDCBFDG_00885 1.3e-81 tlpA2 L Transposase IS200 like
HKDCBFDG_00890 7.9e-16 traP 1.14.99.57, 6.2.1.3 S enzyme involved in biosynthesis of extracellular polysaccharides
HKDCBFDG_00891 1.7e-69 spxA 1.20.4.1 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
HKDCBFDG_00892 9.1e-114 mecA NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
HKDCBFDG_00893 1.7e-201 coiA 3.6.4.12 S Competence protein
HKDCBFDG_00894 3.6e-114 yjbH Q Thioredoxin
HKDCBFDG_00895 6e-123 yjbM 2.7.6.5 S RelA SpoT domain protein
HKDCBFDG_00896 1e-153 nadK 2.7.1.23 F Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HKDCBFDG_00897 8.2e-173 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 G Responsible for synthesis of pseudouridine from uracil
HKDCBFDG_00898 1.4e-195 pgl 3.1.1.31 G Lactonase, 7-bladed beta-propeller
HKDCBFDG_00899 2.2e-162 rrmA 2.1.1.187 H Methyltransferase
HKDCBFDG_00900 6.7e-95 trmL 2.1.1.207 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
HKDCBFDG_00901 0.0 ftsK D Belongs to the FtsK SpoIIIE SftA family
HKDCBFDG_00902 1.2e-07 S Protein of unknown function (DUF4044)
HKDCBFDG_00903 9.8e-58
HKDCBFDG_00904 2.1e-78 mraZ K Belongs to the MraZ family
HKDCBFDG_00905 1.1e-172 rsmH 2.1.1.199 J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
HKDCBFDG_00906 3.5e-08 ftsL D Cell division protein FtsL
HKDCBFDG_00907 0.0 ftsI 3.4.16.4 M Penicillin-binding Protein
HKDCBFDG_00908 9.1e-178 mraY 2.7.8.13 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HKDCBFDG_00909 4.3e-261 murD 6.3.2.9 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HKDCBFDG_00910 2.8e-202 murG 2.4.1.227, 6.3.2.8 GT28 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HKDCBFDG_00911 8.4e-151 divIB D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
HKDCBFDG_00912 2.7e-223 ftsA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
HKDCBFDG_00913 6.7e-216 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HKDCBFDG_00914 1.2e-74 sepF D Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
HKDCBFDG_00915 6.8e-41 yggT S YGGT family
HKDCBFDG_00916 4.1e-144 ylmH S S4 domain protein
HKDCBFDG_00917 2.3e-98 divIVA D DivIVA domain protein
HKDCBFDG_00919 0.0 ileS 6.1.1.5 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HKDCBFDG_00920 6e-31 cspB K Cold shock protein
HKDCBFDG_00921 2.7e-97 nudF 3.6.1.13 L ADP-ribose pyrophosphatase
HKDCBFDG_00923 4.6e-126 mtnN 3.2.2.9 E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HKDCBFDG_00924 7.6e-58 XK27_04120 S Putative amino acid metabolism
HKDCBFDG_00925 6.5e-223 mnmA 2.8.1.13 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
HKDCBFDG_00926 1.2e-19 S amidohydrolase
HKDCBFDG_00927 3.4e-225 dacA 3.4.16.4 M Belongs to the peptidase S11 family
HKDCBFDG_00928 2e-97
HKDCBFDG_00929 2.3e-198 pgl 3.1.1.31 G Lactonase, 7-bladed beta-propeller
HKDCBFDG_00930 4.7e-108 lssY 3.6.1.27 I Acid phosphatase homologues
HKDCBFDG_00931 1.6e-54 S MazG-like family
HKDCBFDG_00932 0.0 L Helicase C-terminal domain protein
HKDCBFDG_00933 2.1e-70 nudG 3.6.1.55, 3.6.1.65 L NUDIX domain
HKDCBFDG_00934 5.5e-95 K transcriptional regulator
HKDCBFDG_00935 1.6e-247 lmrB EGP Major facilitator Superfamily
HKDCBFDG_00936 1.4e-13 S Domain of unknown function (DUF4811)
HKDCBFDG_00939 3.5e-38 S Cytochrome B5
HKDCBFDG_00940 3e-89 luxS 4.4.1.21 H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
HKDCBFDG_00941 1.1e-214 2.1.1.14 E methionine synthase, vitamin-B12 independent
HKDCBFDG_00942 3.9e-36 yjjG 3.1.3.102, 3.1.3.104, 3.1.3.5, 3.8.1.2 S Haloacid dehalogenase-like hydrolase
HKDCBFDG_00943 1e-195 asnA 6.3.1.1 F aspartate--ammonia ligase
HKDCBFDG_00944 2.4e-104 3.2.1.17 NU mannosyl-glycoprotein
HKDCBFDG_00945 1.1e-92 wecD K Acetyltransferase (GNAT) family
HKDCBFDG_00946 8.8e-284 dinB 2.7.7.7 L impB/mucB/samB family C-terminal domain
HKDCBFDG_00947 5.9e-82 S Psort location Cytoplasmic, score
HKDCBFDG_00948 1.4e-69 K helix_turn_helix, mercury resistance
HKDCBFDG_00949 4.6e-134 ybgJ 3.5.1.54 E Allophanate hydrolase subunit 1
HKDCBFDG_00950 7.6e-191 kipA 6.3.4.6 E Allophanate hydrolase subunit 2
HKDCBFDG_00951 4.8e-54 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
HKDCBFDG_00952 2.2e-257 accC 6.3.4.14, 6.4.1.2 I Acetyl-CoA carboxylase biotin carboxylase subunit
HKDCBFDG_00953 1.1e-133 ycsF S LamB/YcsF family
HKDCBFDG_00954 3.8e-205 ycsG P Natural resistance-associated macrophage protein
HKDCBFDG_00955 4.6e-208 EGP Major facilitator Superfamily
HKDCBFDG_00956 2.2e-254 gor 1.8.1.7 C pyridine nucleotide-disulfide oxidoreductase
HKDCBFDG_00957 9.7e-52 trxA O Belongs to the thioredoxin family
HKDCBFDG_00958 1.1e-151 mleP3 S Membrane transport protein
HKDCBFDG_00960 2e-140 L PFAM Integrase catalytic region
HKDCBFDG_00961 6.4e-249 EGP Major facilitator Superfamily
HKDCBFDG_00962 8e-182 ribF 2.7.1.26, 2.7.7.2 H Belongs to the ribF family
HKDCBFDG_00963 6.8e-167 truB 5.4.99.25 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HKDCBFDG_00964 4.2e-59 rbfA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HKDCBFDG_00965 0.0 infB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HKDCBFDG_00966 7.1e-50 ylxQ J ribosomal protein
HKDCBFDG_00967 1.4e-47 ylxR K Protein of unknown function (DUF448)
HKDCBFDG_00968 2e-222 nusA K Participates in both transcription termination and antitermination
HKDCBFDG_00969 1.2e-82 rimP J Required for maturation of 30S ribosomal subunits
HKDCBFDG_00970 0.0 polC 2.7.7.7 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HKDCBFDG_00971 0.0 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
HKDCBFDG_00972 2.2e-232 rseP 3.4.21.107, 3.4.21.116 M zinc metalloprotease
HKDCBFDG_00973 3e-134 cdsA 2.7.7.41 I Belongs to the CDS family
HKDCBFDG_00974 3.2e-141 uppS 2.5.1.31 H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HKDCBFDG_00975 4.1e-93 frr J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
HKDCBFDG_00976 7.8e-129 pyrH 2.7.4.22 F Catalyzes the reversible phosphorylation of UMP to UDP
HKDCBFDG_00977 1.2e-152 tsf J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HKDCBFDG_00978 4.7e-140 rpsB J Belongs to the universal ribosomal protein uS2 family
HKDCBFDG_00979 1.3e-45 yazA L GIY-YIG catalytic domain protein
HKDCBFDG_00980 1.2e-132 yabB 2.1.1.223 L Methyltransferase small domain
HKDCBFDG_00981 4.4e-112 plsC 2.3.1.51 I Acyltransferase
HKDCBFDG_00982 2.7e-27 yneF S Uncharacterised protein family (UPF0154)
HKDCBFDG_00983 2.7e-36 ynzC S UPF0291 protein
HKDCBFDG_00984 7.9e-114 lexA 3.4.21.88 K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HKDCBFDG_00985 1.8e-215 mvaS 2.3.3.10 I Hydroxymethylglutaryl-CoA synthase
HKDCBFDG_00986 8.4e-239 lutB C 4Fe-4S dicluster domain
HKDCBFDG_00987 5.7e-87 yrjD S LUD domain
HKDCBFDG_00988 8.3e-25 S domain, Protein
HKDCBFDG_00989 2.3e-39 ywnB S NAD(P)H-binding
HKDCBFDG_00990 1.4e-65 yjcE P Sodium proton antiporter
HKDCBFDG_00991 1.3e-75
HKDCBFDG_00992 1.3e-184
HKDCBFDG_00993 3.3e-129 narI 1.7.5.1 C Nitrate reductase
HKDCBFDG_00994 9.2e-102 narJ C Nitrate reductase delta subunit
HKDCBFDG_00995 0.0 narH 1.7.5.1 C Respiratory nitrate reductase beta C-terminal
HKDCBFDG_00996 0.0 narG 1.7.5.1 C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HKDCBFDG_00997 1.4e-189 moeB 2.7.7.73, 2.7.7.80 H ThiF family
HKDCBFDG_00998 1.9e-86 moaB 2.7.7.75 H May be involved in the biosynthesis of molybdopterin
HKDCBFDG_00999 1.2e-230 moeA 2.10.1.1 H MoeA N-terminal region (domain I and II)
HKDCBFDG_01000 7.2e-85 moaC 4.6.1.17 H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)
HKDCBFDG_01001 3.1e-98 mobA 2.7.7.77 H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
HKDCBFDG_01002 4.2e-40
HKDCBFDG_01003 1.4e-77 nreA T GAF domain
HKDCBFDG_01004 1.4e-182 comP 2.7.13.3 F Sensor histidine kinase
HKDCBFDG_01005 4e-116 nreC K PFAM regulatory protein LuxR
HKDCBFDG_01006 1.2e-39
HKDCBFDG_01007 6.7e-184
HKDCBFDG_01008 2e-169 hepT 2.5.1.30, 2.5.1.90 H geranyltranstransferase activity
HKDCBFDG_01010 3e-133 menG 2.1.1.163, 2.1.1.201 H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)
HKDCBFDG_01011 3.2e-161 hipB K Helix-turn-helix
HKDCBFDG_01012 1.5e-58 yitW S Iron-sulfur cluster assembly protein
HKDCBFDG_01013 2.4e-215 narK P Major Facilitator Superfamily
HKDCBFDG_01014 7.8e-196 moaA 4.1.99.22 H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HKDCBFDG_01015 6.4e-35 moaD 2.8.1.12 H ThiS family
HKDCBFDG_01016 2.2e-72 moaE 2.8.1.12 H MoaE protein
HKDCBFDG_01017 5.4e-56 S Flavodoxin
HKDCBFDG_01018 1.5e-170 fecD P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKDCBFDG_01019 1e-142 fecE 3.6.3.34 HP AAA domain, putative AbiEii toxin, Type IV TA system
HKDCBFDG_01020 5.9e-230 ndh 1.6.99.3 C NADH dehydrogenase
HKDCBFDG_01021 8e-54 yitW S Iron-sulfur cluster assembly protein
HKDCBFDG_01022 5.2e-18 M1-755 S Domain of unknown function (DUF1858)
HKDCBFDG_01023 2.1e-257 XK27_04775 S PAS domain
HKDCBFDG_01024 5.4e-142 EG EamA-like transporter family
HKDCBFDG_01025 4.7e-151 tesE Q hydratase
HKDCBFDG_01026 8.6e-187 ldhA 1.1.1.28 C Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HKDCBFDG_01027 2.5e-62 S Domain of unknown function (DUF4440)
HKDCBFDG_01028 2.4e-95 apt 2.4.2.22, 2.4.2.7 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HKDCBFDG_01029 0.0 recJ L Single-stranded-DNA-specific exonuclease RecJ
HKDCBFDG_01030 1.9e-155 XK27_05435 1.1.1.100 S Belongs to the short-chain dehydrogenases reductases (SDR) family
HKDCBFDG_01031 3.2e-175 rnz 3.1.26.11 J Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
HKDCBFDG_01032 8.7e-248 obg S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HKDCBFDG_01033 0.0 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
HKDCBFDG_01034 1.7e-134 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
HKDCBFDG_01036 8.3e-53 MA20_27270 S mazG nucleotide pyrophosphohydrolase
HKDCBFDG_01037 8.9e-107 engB D Necessary for normal cell division and for the maintenance of normal septation
HKDCBFDG_01038 5.8e-233 clpX O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HKDCBFDG_01039 1.6e-212 tig D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
HKDCBFDG_01040 4.3e-225 tuf J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HKDCBFDG_01041 9.5e-161 S Tetratricopeptide repeat
HKDCBFDG_01042 0.0 rnjB J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HKDCBFDG_01043 3.7e-257 gshF 6.3.2.2 H Belongs to the glutamate--cysteine ligase type 1 family
HKDCBFDG_01044 4.6e-42 rpsO J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HKDCBFDG_01045 3.9e-35 rpsT J Binds directly to 16S ribosomal RNA
HKDCBFDG_01046 7e-184 holA 2.7.7.7 L DNA polymerase III delta subunit
HKDCBFDG_01047 0.0 comEC S Competence protein ComEC
HKDCBFDG_01048 3.4e-88 comEB 3.5.4.12 F ComE operon protein 2
HKDCBFDG_01049 2.5e-89 comEA L Competence protein ComEA
HKDCBFDG_01050 7.4e-197 ylbL T Belongs to the peptidase S16 family
HKDCBFDG_01051 2.8e-88 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HKDCBFDG_01052 4.9e-99 rsmD 2.1.1.171 L RNA methyltransferase, RsmD family
HKDCBFDG_01053 4e-47 ylbG S Uncharacterized protein conserved in bacteria (DUF2129)
HKDCBFDG_01054 1.1e-212 ftsW D Belongs to the SEDS family
HKDCBFDG_01055 0.0 typA T GTP-binding protein TypA
HKDCBFDG_01056 2.8e-137 suhB 3.1.3.25 G Belongs to the inositol monophosphatase superfamily
HKDCBFDG_01057 2.4e-49 yktA S Belongs to the UPF0223 family
HKDCBFDG_01058 7.5e-103 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
HKDCBFDG_01059 1.2e-74
HKDCBFDG_01060 2.2e-31 ykzG S Belongs to the UPF0356 family
HKDCBFDG_01061 4e-189 ytlR 2.7.1.91 I Diacylglycerol kinase catalytic
HKDCBFDG_01062 4.2e-74 spx4 1.20.4.1 P ArsC family
HKDCBFDG_01063 9.4e-178 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HKDCBFDG_01064 0.0 recD 3.1.11.5 L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
HKDCBFDG_01065 7.1e-124 S Repeat protein
HKDCBFDG_01066 9.2e-121 pgm6 5.4.2.11, 5.4.2.12 G phosphoglycerate mutase
HKDCBFDG_01067 3.4e-169 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
HKDCBFDG_01068 2.3e-131 S amidohydrolase
HKDCBFDG_01069 3.8e-44 S amidohydrolase
HKDCBFDG_01070 1.3e-159
HKDCBFDG_01071 8.4e-75 K Transcriptional regulator
HKDCBFDG_01072 5.4e-186 D Alpha beta
HKDCBFDG_01073 1.6e-73 O OsmC-like protein
HKDCBFDG_01074 8.4e-190 lplA2 6.3.1.20 H Bacterial lipoate protein ligase C-terminus
HKDCBFDG_01075 0.0 yjcE P Sodium proton antiporter
HKDCBFDG_01076 1.7e-15 yvlA
HKDCBFDG_01077 5.7e-115 P Cobalt transport protein
HKDCBFDG_01078 2.5e-253 cbiO1 S ABC transporter, ATP-binding protein
HKDCBFDG_01079 1.6e-100 S ABC-type cobalt transport system, permease component
HKDCBFDG_01080 3.4e-180 iunH2 3.2.2.1 F nucleoside hydrolase
HKDCBFDG_01081 4.4e-183 yumC 1.18.1.2, 1.19.1.1, 1.8.1.9 C Ferredoxin--NADP reductase
HKDCBFDG_01082 0.0 cadA 3.6.3.3, 3.6.3.5 P P-type ATPase
HKDCBFDG_01083 2.8e-32 copZ P Heavy-metal-associated domain
HKDCBFDG_01084 8.8e-101 dps P Belongs to the Dps family
HKDCBFDG_01085 1.5e-105 rcfA 4.1.99.16, 4.2.3.22, 4.2.3.75 K helix_turn_helix, cAMP Regulatory protein
HKDCBFDG_01086 2e-85
HKDCBFDG_01087 0.0 ltaS 2.7.8.20 M Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
HKDCBFDG_01088 1.2e-125 pgm3 G phosphoglycerate mutase family
HKDCBFDG_01089 3.8e-172 3.2.1.55 GH51 G Alpha-L-arabinofuranosidase C-terminus
HKDCBFDG_01090 5.3e-79 mleR K LysR family
HKDCBFDG_01091 1.2e-230 sfcA 1.1.1.38, 4.1.1.101 C Malic enzyme
HKDCBFDG_01092 6e-183 XK27_09615 S reductase
HKDCBFDG_01093 1.9e-91 XK27_09620 S NADPH-dependent FMN reductase
HKDCBFDG_01094 6.1e-223 fumC 4.2.1.2 C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
HKDCBFDG_01095 3.6e-215 frdC 1.3.5.4 C FAD binding domain
HKDCBFDG_01096 1.9e-224 yflS P Sodium:sulfate symporter transmembrane region
HKDCBFDG_01097 1.1e-161 mleR K LysR family transcriptional regulator
HKDCBFDG_01098 3.2e-253 yjjP S Putative threonine/serine exporter
HKDCBFDG_01099 2.1e-120 ung2 3.2.2.27 L Uracil-DNA glycosylase
HKDCBFDG_01100 3.1e-189 I Alpha beta
HKDCBFDG_01101 2.7e-108 thiJ 2.7.11.1, 3.5.1.124 S DJ-1/PfpI family
HKDCBFDG_01102 0.0 mprF 2.3.2.3 S Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HKDCBFDG_01104 1.3e-170 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 J Responsible for synthesis of pseudouridine from uracil
HKDCBFDG_01105 1.8e-185 S interspecies interaction between organisms
HKDCBFDG_01106 1.5e-65 rpsI J Belongs to the universal ribosomal protein uS9 family
HKDCBFDG_01107 2.6e-79 rplM J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HKDCBFDG_01108 5.4e-144 truA 5.4.99.12 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
HKDCBFDG_01109 1.4e-139 ecfT U Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HKDCBFDG_01110 2e-155 ecfA2 3.6.3.55 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HKDCBFDG_01111 2e-149 cbiO P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HKDCBFDG_01112 2.8e-61 rplQ J Ribosomal protein L17
HKDCBFDG_01113 2e-169 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HKDCBFDG_01114 1e-63 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HKDCBFDG_01115 9.5e-59 rpsM J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HKDCBFDG_01116 3.3e-13 rpmJ J Belongs to the bacterial ribosomal protein bL36 family
HKDCBFDG_01117 2e-32 infA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HKDCBFDG_01118 4.1e-121 adk 2.7.4.3 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
HKDCBFDG_01119 4.2e-234 secY U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
HKDCBFDG_01120 2.1e-65 rplO J Binds to the 23S rRNA
HKDCBFDG_01121 2.5e-23 rpmD J Ribosomal protein L30
HKDCBFDG_01122 9.7e-86 rpsE J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HKDCBFDG_01123 3.9e-57 rplR J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HKDCBFDG_01124 5.1e-93 rplF J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HKDCBFDG_01125 1e-66 rpsH J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HKDCBFDG_01126 5.2e-29 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HKDCBFDG_01127 4.2e-95 rplE J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HKDCBFDG_01128 8.9e-50 rplX J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HKDCBFDG_01129 6.6e-60 rplN J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HKDCBFDG_01130 6.5e-41 rpsQ J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HKDCBFDG_01131 3.2e-27 rpmC J Belongs to the universal ribosomal protein uL29 family
HKDCBFDG_01132 2.3e-75 rplP J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HKDCBFDG_01133 3.5e-104 rpsC J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HKDCBFDG_01134 2.2e-52 rplV J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HKDCBFDG_01135 8.4e-47 rpsS J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HKDCBFDG_01136 9.3e-150 rplB J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HKDCBFDG_01137 4.8e-45 rplW J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
HKDCBFDG_01138 3e-105 rplD J Forms part of the polypeptide exit tunnel
HKDCBFDG_01139 8.7e-119 rplC J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HKDCBFDG_01140 2.6e-49 rpsJ J Involved in the binding of tRNA to the ribosomes
HKDCBFDG_01143 7.9e-117 dak 2.7.1.74, 2.7.1.76 F deoxynucleoside kinase
HKDCBFDG_01144 3.9e-268 lysP E amino acid
HKDCBFDG_01146 8.3e-156 I alpha/beta hydrolase fold
HKDCBFDG_01147 9.1e-116 lssY 3.6.1.27 I phosphatase
HKDCBFDG_01148 3.7e-82 S Threonine/Serine exporter, ThrE
HKDCBFDG_01149 1.8e-125 thrE S Putative threonine/serine exporter
HKDCBFDG_01150 1.3e-30 cspA K Cold shock protein
HKDCBFDG_01151 1.2e-123 sirR K iron dependent repressor
HKDCBFDG_01152 3.5e-163 czcD P cation diffusion facilitator family transporter
HKDCBFDG_01153 2.5e-116 S membrane
HKDCBFDG_01154 5.3e-111 S VIT family
HKDCBFDG_01155 4.5e-85 usp1 T Belongs to the universal stress protein A family
HKDCBFDG_01156 8.1e-33 elaA S GNAT family
HKDCBFDG_01157 8.2e-216 S CAAX protease self-immunity
HKDCBFDG_01158 0.0 rnjA J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HKDCBFDG_01159 3.1e-59
HKDCBFDG_01160 1.9e-74 merR K MerR HTH family regulatory protein
HKDCBFDG_01161 6.6e-268 lmrB EGP Major facilitator Superfamily
HKDCBFDG_01162 2e-113 S Domain of unknown function (DUF4811)
HKDCBFDG_01163 8.5e-150 araA 5.3.1.4 G Catalyzes the conversion of L-arabinose to L-ribulose
HKDCBFDG_01164 1.3e-159 D nuclear chromosome segregation
HKDCBFDG_01165 3.7e-258 dtpT U amino acid peptide transporter
HKDCBFDG_01166 2.1e-165 yjjH S Calcineurin-like phosphoesterase
HKDCBFDG_01169 1.1e-115
HKDCBFDG_01170 4.3e-132 racD 5.1.1.13 M Belongs to the aspartate glutamate racemases family
HKDCBFDG_01171 1.2e-126 gntR1 K UbiC transcription regulator-associated domain protein
HKDCBFDG_01172 3.8e-284 pncB 6.3.4.21 F Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HKDCBFDG_01173 8.8e-153 nadE 6.3.1.5 F Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
HKDCBFDG_01174 0.0 yhgF K Tex-like protein N-terminal domain protein
HKDCBFDG_01175 1.2e-82 ydcK S Belongs to the SprT family
HKDCBFDG_01177 0.0 lacL 3.2.1.23 G Belongs to the glycosyl hydrolase 2 family
HKDCBFDG_01178 4e-189 lacM 3.2.1.23, 3.2.1.35, 3.2.1.51, 3.2.1.97 GH101,GH29 G beta-galactosidase
HKDCBFDG_01179 5.5e-167 mleP2 S Sodium Bile acid symporter family
HKDCBFDG_01180 6.1e-128 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HKDCBFDG_01181 4.3e-166 I alpha/beta hydrolase fold
HKDCBFDG_01182 1.6e-12 S Domain of unknown function (DUF4767)
HKDCBFDG_01183 1.3e-54 crcB U Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HKDCBFDG_01184 2.2e-55 crcB D Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HKDCBFDG_01185 4.9e-69 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HKDCBFDG_01186 1.1e-103 wecD3 K Acetyltransferase (GNAT) family
HKDCBFDG_01187 2.8e-310 ubiB S ABC1 family
HKDCBFDG_01188 2e-129 1.14.12.17 C Oxidoreductase NAD-binding domain
HKDCBFDG_01189 1.1e-169 GK ROK family
HKDCBFDG_01190 1.5e-40
HKDCBFDG_01191 4.2e-80 copY K Copper transport repressor CopY TcrY
HKDCBFDG_01193 1.2e-50 3.6.3.6 P Cation transporter/ATPase, N-terminus
HKDCBFDG_01194 5.8e-148 mutR K Transcriptional activator, Rgg GadR MutR family
HKDCBFDG_01195 1e-287 gntK 2.7.1.12, 2.7.1.17 G Belongs to the FGGY kinase family
HKDCBFDG_01196 4.2e-229 gntT EG Gluconate
HKDCBFDG_01197 2.4e-181 K Transcriptional regulator, LacI family
HKDCBFDG_01198 4.3e-61 yneR
HKDCBFDG_01199 6.3e-221 aspB 2.6.1.1, 2.6.1.14 E Aminotransferase
HKDCBFDG_01200 2.2e-96 V VanZ like family
HKDCBFDG_01201 1.6e-290 gshF 6.3.2.2 H Belongs to the glutamate--cysteine ligase type 1 family
HKDCBFDG_01202 4.1e-58
HKDCBFDG_01203 1e-207 lmrP E Major Facilitator Superfamily
HKDCBFDG_01204 4.1e-235 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
HKDCBFDG_01205 3.4e-74 rplI J Binds to the 23S rRNA
HKDCBFDG_01206 0.0 yybT T signaling protein consisting of a modified GGDEF domain and a DHH domain
HKDCBFDG_01207 2.1e-35 rpsR J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HKDCBFDG_01208 1.7e-88 ssb L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
HKDCBFDG_01209 3.6e-48 rpsF J Binds together with S18 to 16S ribosomal RNA
HKDCBFDG_01210 0.0 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HKDCBFDG_01211 0.0 gyrB 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HKDCBFDG_01212 3.4e-200 recF L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HKDCBFDG_01213 2.2e-34 yaaA S S4 domain protein YaaA
HKDCBFDG_01214 4.2e-206 dnaN 2.7.7.7 L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
HKDCBFDG_01215 1.5e-247 dnaA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HKDCBFDG_01216 2.6e-14 rpmH J Belongs to the bacterial ribosomal protein bL34 family
HKDCBFDG_01217 1.9e-56 rnpA 3.1.26.5 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
HKDCBFDG_01218 1.5e-144 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HKDCBFDG_01219 4.8e-79 ctsR K Belongs to the CtsR family
HKDCBFDG_01220 0.0 clpC O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
HKDCBFDG_01221 1.3e-105 K Bacterial regulatory proteins, tetR family
HKDCBFDG_01222 0.0 rpoB 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HKDCBFDG_01223 0.0 rpoC 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HKDCBFDG_01224 5.6e-135 puuD S peptidase C26
HKDCBFDG_01225 7.4e-214 ykiI
HKDCBFDG_01226 2.1e-32 pilD 3.4.23.43 NOU aspartic-type endopeptidase activity
HKDCBFDG_01227 3.2e-71 rpsL J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HKDCBFDG_01228 7.1e-83 rpsG J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
HKDCBFDG_01229 0.0 fusA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HKDCBFDG_01230 6.6e-153 yitU 3.1.3.104 S hydrolase
HKDCBFDG_01231 9.7e-274 rsmF 2.1.1.176, 2.1.1.178 J NOL1 NOP2 sun family protein
HKDCBFDG_01232 9e-92 pstS P Phosphate
HKDCBFDG_01233 1.2e-97 pstC P probably responsible for the translocation of the substrate across the membrane
HKDCBFDG_01234 1.3e-103 pstA P Phosphate transport system permease protein PstA
HKDCBFDG_01235 2.8e-95 pstB 3.6.3.27 L Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
HKDCBFDG_01236 2.4e-203 fni 1.1.1.88, 5.3.3.2 C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
HKDCBFDG_01237 1.6e-210 mvaK2 2.7.1.36, 2.7.1.43, 2.7.4.2 I phosphomevalonate kinase
HKDCBFDG_01238 4.5e-180 mvaD 4.1.1.33 I diphosphomevalonate decarboxylase
HKDCBFDG_01239 1.4e-167 mvk 1.1.1.88, 2.3.3.10, 2.7.1.36 I mevalonate kinase
HKDCBFDG_01240 0.0 dinG 2.7.7.7, 3.6.4.12 L helicase involved in DNA repair and perhaps also replication
HKDCBFDG_01241 2.4e-87 ypmB S Protein conserved in bacteria
HKDCBFDG_01242 7.8e-257 asnS 6.1.1.22 J Asparaginyl-tRNA synthetase
HKDCBFDG_01243 4.7e-134 dnaD L DnaD domain protein
HKDCBFDG_01244 5.4e-120 ypuA S Protein of unknown function (DUF1002)
HKDCBFDG_01245 7.3e-251 nylA 3.5.1.4 J Belongs to the amidase family
HKDCBFDG_01246 2.4e-204 arcD S C4-dicarboxylate anaerobic carrier
HKDCBFDG_01247 4.8e-193 ytjP 3.5.1.18 E Dipeptidase
HKDCBFDG_01248 7.9e-213 rlmL 2.1.1.173, 2.1.1.264 L Belongs to the methyltransferase superfamily
HKDCBFDG_01249 8.9e-83 F Hydrolase, NUDIX family
HKDCBFDG_01250 3.7e-210 S Type IV secretion-system coupling protein DNA-binding domain
HKDCBFDG_01251 0.0 tetP J elongation factor G
HKDCBFDG_01252 4.6e-58 gpsB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
HKDCBFDG_01253 2.7e-111 ypsA S Belongs to the UPF0398 family
HKDCBFDG_01254 3e-116 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
HKDCBFDG_01255 0.0 ponA 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein 1A
HKDCBFDG_01256 2.4e-159 EG EamA-like transporter family
HKDCBFDG_01257 1.2e-191 C Aldo keto reductase family protein
HKDCBFDG_01258 1.2e-138 IQ reductase
HKDCBFDG_01259 5.8e-109 acmC 3.2.1.17, 3.2.1.96 NU mannosyl-glycoprotein
HKDCBFDG_01260 9.5e-101 xpt 2.4.2.22, 2.4.2.7 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
HKDCBFDG_01261 1.4e-220 purK2 6.3.4.18 F Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HKDCBFDG_01262 0.0 pcrA 3.6.4.12 L ATP-dependent DNA helicase
HKDCBFDG_01263 0.0 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HKDCBFDG_01264 3.2e-166 camS S sex pheromone
HKDCBFDG_01265 2.1e-49 gatC 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HKDCBFDG_01266 1.1e-272 gatA 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
HKDCBFDG_01267 5e-273 gatB 6.1.1.12, 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HKDCBFDG_01268 5.7e-186 yegS 2.7.1.107 G Lipid kinase
HKDCBFDG_01269 1.9e-261 rumA 2.1.1.190 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HKDCBFDG_01270 1.4e-49 K TRANSCRIPTIONal
HKDCBFDG_01271 5.3e-229 serS 6.1.1.11 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HKDCBFDG_01272 0.0 sbcC L Putative exonuclease SbcCD, C subunit
HKDCBFDG_01273 3.3e-219 sbcD L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
HKDCBFDG_01275 4.1e-297 dltA 6.1.1.13 H Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HKDCBFDG_01276 7e-239 dltB M MBOAT, membrane-bound O-acyltransferase family
HKDCBFDG_01277 4.7e-35 dltC 6.1.1.13 J Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HKDCBFDG_01278 1.2e-241 dltD M Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HKDCBFDG_01279 2.2e-123 iolS C Aldo keto reductase
HKDCBFDG_01280 4.8e-196 brnQ U Component of the transport system for branched-chain amino acids
HKDCBFDG_01281 1.2e-245 rumA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HKDCBFDG_01283 4e-22
HKDCBFDG_01284 1.6e-247 cycA E Amino acid permease
HKDCBFDG_01285 7.4e-85 perR P Belongs to the Fur family
HKDCBFDG_01286 7.3e-248 EGP Major facilitator Superfamily
HKDCBFDG_01287 5.8e-97 tag 3.2.2.20 L glycosylase
HKDCBFDG_01288 1.6e-52
HKDCBFDG_01289 1.1e-209 metK 2.5.1.6 H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HKDCBFDG_01290 1.1e-139 proB 2.7.2.11 F Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HKDCBFDG_01291 8.4e-224 proA 1.2.1.41 E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HKDCBFDG_01292 7.8e-126 3.1.3.2, 3.1.3.27, 3.1.3.4, 3.1.3.81, 3.6.1.27 I Acid phosphatase homologues
HKDCBFDG_01293 0.0 leuS 6.1.1.4 J Belongs to the class-I aminoacyl-tRNA synthetase family
HKDCBFDG_01294 3.4e-143 ywqE 3.1.3.48 GM PHP domain protein
HKDCBFDG_01295 1e-115 ywqD 2.7.10.1 D Capsular exopolysaccharide family
HKDCBFDG_01296 8e-132 epsB M biosynthesis protein
HKDCBFDG_01297 2.4e-160 brpA K Cell envelope-like function transcriptional attenuator common domain protein
HKDCBFDG_01298 3.5e-208 guaB 1.1.1.205 F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
HKDCBFDG_01299 2.7e-135 XK27_01040 S Protein of unknown function (DUF1129)
HKDCBFDG_01300 4.4e-200 ychF J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
HKDCBFDG_01301 9.3e-32 yyzM S Bacterial protein of unknown function (DUF951)
HKDCBFDG_01302 1.1e-147 spo0J K Belongs to the ParB family
HKDCBFDG_01303 8.7e-157 noc K Belongs to the ParB family
HKDCBFDG_01304 3.1e-133 rsmG 2.1.1.170 J Specifically methylates the N7 position of a guanine in 16S rRNA
HKDCBFDG_01305 2.2e-144 rihC 3.2.2.1 F Nucleoside
HKDCBFDG_01306 4.9e-213 nupG F Nucleoside transporter
HKDCBFDG_01307 1e-284 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HKDCBFDG_01308 4.8e-193 ampC V Beta-lactamase
HKDCBFDG_01309 0.0 yfiC V ABC transporter
HKDCBFDG_01310 0.0 lmrA V ABC transporter, ATP-binding protein
HKDCBFDG_01311 1.8e-78 K Winged helix DNA-binding domain
HKDCBFDG_01312 3.5e-08
HKDCBFDG_01314 3.6e-57
HKDCBFDG_01316 6.6e-133 budA 4.1.1.5 H Belongs to the alpha-acetolactate decarboxylase family
HKDCBFDG_01317 1.1e-144 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
HKDCBFDG_01318 7.6e-160 ytbE 1.1.1.346 S Aldo keto reductase
HKDCBFDG_01319 3.4e-121 XK27_08875 O PFAM peptidase M10A and M12B, matrixin and adamalysin
HKDCBFDG_01320 1.6e-85 K GNAT family
HKDCBFDG_01322 9.7e-39 ykuJ S Protein of unknown function (DUF1797)
HKDCBFDG_01323 1.9e-181 mprF I Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HKDCBFDG_01324 4.5e-199 cpoA GT4 M Glycosyltransferase, group 1 family protein
HKDCBFDG_01325 5e-229 mgs 2.4.1.337 GT4 M Glycosyltransferase, group 1 family protein
HKDCBFDG_01326 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HKDCBFDG_01327 8e-39 ptsH G phosphocarrier protein HPR
HKDCBFDG_01329 0.0 clpE O Belongs to the ClpA ClpB family
HKDCBFDG_01330 4.9e-128 3.6.1.13, 3.6.1.55 F NUDIX domain
HKDCBFDG_01331 7.8e-108 pncA Q Isochorismatase family
HKDCBFDG_01332 6.4e-260 pncB 6.3.4.21 F Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HKDCBFDG_01333 1e-117 yecS E ABC transporter permease
HKDCBFDG_01334 1e-156 yckB ET Belongs to the bacterial solute-binding protein 3 family
HKDCBFDG_01335 8.7e-110 XK27_02070 S Nitroreductase family
HKDCBFDG_01336 1.5e-68 rnhA 3.1.26.4 L Ribonuclease HI
HKDCBFDG_01337 1.7e-70 esbA S Family of unknown function (DUF5322)
HKDCBFDG_01338 5.1e-75 lspA 3.4.23.36 MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HKDCBFDG_01339 2.6e-174 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
HKDCBFDG_01340 1.4e-206 carA 6.3.5.5 F Belongs to the CarA family
HKDCBFDG_01341 0.0 carB 6.3.5.5 F Carbamoyl-phosphate synthase
HKDCBFDG_01342 4.4e-120 cah 4.2.1.1 P Eukaryotic-type carbonic anhydrase
HKDCBFDG_01343 6.4e-173 K Bacterial regulatory helix-turn-helix protein, lysR family
HKDCBFDG_01344 3.4e-23 S Enoyl-(Acyl carrier protein) reductase
HKDCBFDG_01345 6.5e-136 purC 4.1.1.21, 4.3.2.2, 6.3.2.6 F Belongs to the SAICAR synthetase family
HKDCBFDG_01346 3e-37 purS 6.3.2.6, 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HKDCBFDG_01347 1.6e-128 purQ 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HKDCBFDG_01348 0.0 purL 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HKDCBFDG_01349 6.3e-279 purF 2.4.2.14 F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HKDCBFDG_01350 1.2e-196 purM 6.3.3.1, 6.3.4.13 F Phosphoribosylformylglycinamidine cyclo-ligase
HKDCBFDG_01351 4.3e-106 purN 2.1.2.2 F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HKDCBFDG_01352 3e-292 purH 2.1.2.3, 3.5.4.10 F Bifunctional purine biosynthesis protein PurH
HKDCBFDG_01353 1.8e-242 purD 6.3.4.13 F Belongs to the GARS family
HKDCBFDG_01354 1.2e-68 psiE S Phosphate-starvation-inducible E
HKDCBFDG_01355 1.5e-149 thiD 2.5.1.3, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Phosphomethylpyrimidine kinase
HKDCBFDG_01356 1.1e-113 thiE 2.5.1.3 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
HKDCBFDG_01357 1.6e-143 thiD 2.5.1.3, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Phosphomethylpyrimidine kinase
HKDCBFDG_01358 6.9e-139 thiM 2.7.1.50 H Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HKDCBFDG_01359 0.0 M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HKDCBFDG_01360 1.5e-115 bm3R1 K Bacterial regulatory proteins, tetR family
HKDCBFDG_01361 0.0 yhcA V ABC transporter, ATP-binding protein
HKDCBFDG_01362 4.7e-50 S FMN_bind
HKDCBFDG_01363 1.2e-66 apbE 2.7.1.180 H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
HKDCBFDG_01364 2.2e-134 P nitric oxide dioxygenase activity
HKDCBFDG_01365 1.5e-48 XK27_08850 S Aminoacyl-tRNA editing domain
HKDCBFDG_01366 3.5e-165 M Membrane
HKDCBFDG_01367 3.4e-23 XK27_06785 V ABC transporter
HKDCBFDG_01368 1.7e-99 K Transcriptional regulator
HKDCBFDG_01369 3.8e-103 dedA S SNARE-like domain protein
HKDCBFDG_01370 2.6e-25 S Protein of unknown function (DUF1461)
HKDCBFDG_01371 1.2e-140 nagD 2.7.1.25, 3.1.3.41 G Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
HKDCBFDG_01372 1.2e-97 yutD S Protein of unknown function (DUF1027)
HKDCBFDG_01373 3.8e-108 S Calcineurin-like phosphoesterase
HKDCBFDG_01374 2.1e-224 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HKDCBFDG_01375 7.3e-158 ytxK 2.1.1.72 L N-6 DNA Methylase
HKDCBFDG_01377 1.3e-14
HKDCBFDG_01379 2.3e-15 NU general secretion pathway protein
HKDCBFDG_01380 1.1e-47 comGC U competence protein ComGC
HKDCBFDG_01381 3.5e-159 comGB NU type II secretion system
HKDCBFDG_01382 7e-178 comGA NU Type II IV secretion system protein
HKDCBFDG_01383 2.6e-106 M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HKDCBFDG_01384 2.1e-238 argG 6.3.4.5 E Belongs to the argininosuccinate synthase family. Type 1 subfamily
HKDCBFDG_01385 5.2e-259 argH 4.3.2.1 E argininosuccinate lyase
HKDCBFDG_01386 1.7e-43 lacA S transferase hexapeptide repeat
HKDCBFDG_01388 7.7e-157 L Thioesterase-like superfamily
HKDCBFDG_01389 7.6e-11 S NADPH-dependent FMN reductase
HKDCBFDG_01390 1.3e-09 S NADPH-dependent FMN reductase
HKDCBFDG_01391 6e-16 S NADPH-dependent FMN reductase
HKDCBFDG_01392 2.3e-241 yfnA E amino acid
HKDCBFDG_01393 6.7e-243 gabT 2.6.1.19 E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HKDCBFDG_01394 4.5e-61 ywkB S Membrane transport protein
HKDCBFDG_01395 1.6e-235 icd 1.1.1.42 C Isocitrate/isopropylmalate dehydrogenase
HKDCBFDG_01396 6.3e-151 pdxK 2.7.1.35 H Phosphomethylpyrimidine kinase
HKDCBFDG_01397 2.6e-80 hmpT S ECF-type riboflavin transporter, S component
HKDCBFDG_01398 5.1e-167 1.1.1.346 C Aldo keto reductase
HKDCBFDG_01399 2.2e-160 S DUF218 domain
HKDCBFDG_01401 5.3e-95 K Acetyltransferase (GNAT) domain
HKDCBFDG_01402 4.3e-163 I alpha/beta hydrolase fold
HKDCBFDG_01403 2.9e-35 osmC O OsmC-like protein
HKDCBFDG_01404 8.2e-41 osmC O OsmC-like protein
HKDCBFDG_01405 1.1e-66 slyA K helix_turn_helix multiple antibiotic resistance protein
HKDCBFDG_01407 6.2e-76 K Transcriptional regulator
HKDCBFDG_01408 2.5e-161 proX M ABC transporter, substrate-binding protein, QAT family
HKDCBFDG_01409 1.5e-107 proWZ P ABC transporter permease
HKDCBFDG_01410 4.2e-141 proV E ABC transporter, ATP-binding protein
HKDCBFDG_01411 1.2e-101 proW P ABC transporter, permease protein
HKDCBFDG_01412 3.4e-180 C Zinc-binding dehydrogenase
HKDCBFDG_01413 3.1e-195 bdhA 1.1.1.303, 1.1.1.4 C Zinc-binding dehydrogenase
HKDCBFDG_01414 8.5e-226 4.4.1.8 E Aminotransferase, class I
HKDCBFDG_01415 9.4e-180 pva3 3.5.1.24 M Linear amide C-N hydrolase, choloylglycine hydrolase family protein
HKDCBFDG_01416 7.1e-203 xerS L Belongs to the 'phage' integrase family
HKDCBFDG_01417 1.6e-154 metQ_4 P Belongs to the nlpA lipoprotein family
HKDCBFDG_01418 9e-204 napA P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
HKDCBFDG_01419 0.0 helD 3.6.4.12 L DNA helicase
HKDCBFDG_01420 2.5e-172 ppx 3.6.1.11, 3.6.1.40 FP exopolyphosphatase
HKDCBFDG_01421 1.4e-218 mvaA 1.1.1.34, 1.1.1.88, 2.3.1.9 C Belongs to the HMG-CoA reductase family
HKDCBFDG_01422 3.2e-186
HKDCBFDG_01423 3.7e-128 cobB K SIR2 family
HKDCBFDG_01424 6.6e-31 S Sugar efflux transporter for intercellular exchange
HKDCBFDG_01425 3.6e-32 higA K Helix-turn-helix XRE-family like proteins
HKDCBFDG_01426 8.1e-93 gadB 4.1.1.15 E Belongs to the group II decarboxylase family
HKDCBFDG_01427 2.9e-16
HKDCBFDG_01428 5.5e-225 aadAT EK Aminotransferase, class I
HKDCBFDG_01429 3.6e-159 gshF 6.3.2.2 H Belongs to the glutamate--cysteine ligase type 1 family
HKDCBFDG_01430 4.1e-142 ET Bacterial periplasmic substrate-binding proteins
HKDCBFDG_01432 1.4e-150 3.1.3.102, 3.1.3.104, 3.1.3.23 S haloacid dehalogenase-like hydrolase
HKDCBFDG_01433 1.2e-155 ykuT M mechanosensitive ion channel
HKDCBFDG_01434 9.2e-26 WQ51_05790 S protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HKDCBFDG_01435 4.9e-70
HKDCBFDG_01436 3.5e-213 pepQ 3.4.13.9 E Creatinase/Prolidase N-terminal domain
HKDCBFDG_01437 1.4e-184 ccpA K catabolite control protein A
HKDCBFDG_01438 6.9e-84
HKDCBFDG_01439 1.4e-133 yebC K Transcriptional regulatory protein
HKDCBFDG_01440 6.4e-84 mltD CBM50 M PFAM NLP P60 protein
HKDCBFDG_01441 2.6e-42
HKDCBFDG_01442 1.5e-297 ytgP S Polysaccharide biosynthesis protein
HKDCBFDG_01443 8e-61 3.2.1.23 S Domain of unknown function DUF302
HKDCBFDG_01444 2.8e-157 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HKDCBFDG_01445 8.4e-273 pepV 3.5.1.18 E dipeptidase PepV
HKDCBFDG_01446 2.5e-86 uspA T Belongs to the universal stress protein A family
HKDCBFDG_01447 3.3e-253 S Putative peptidoglycan binding domain
HKDCBFDG_01448 7.4e-163 3.2.1.17 NU Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
HKDCBFDG_01449 4.1e-167 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
HKDCBFDG_01450 0.0 carB 6.3.5.5 F Carbamoyl-phosphate synthase
HKDCBFDG_01451 8.1e-207 carA 6.3.5.5 F Carbamoyl-phosphate synthetase glutamine chain
HKDCBFDG_01452 1.8e-245 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
HKDCBFDG_01453 1.1e-181 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
HKDCBFDG_01454 1.6e-57 ycsI S Protein of unknown function (DUF1445)
HKDCBFDG_01456 2.1e-140 nfrA 1.5.1.38, 1.5.1.39 C nitroreductase
HKDCBFDG_01457 1.5e-23 phaG GT1 I carboxylic ester hydrolase activity
HKDCBFDG_01458 1.2e-163 K Transcriptional regulator
HKDCBFDG_01459 1.1e-36 morA C Aldo keto reductase
HKDCBFDG_01460 0.0 pepN 3.4.11.2 E aminopeptidase
HKDCBFDG_01461 3.4e-152 1.1.1.1, 1.1.1.14 E alcohol dehydrogenase
HKDCBFDG_01462 2.1e-48 S Mazg nucleotide pyrophosphohydrolase
HKDCBFDG_01463 6.9e-47
HKDCBFDG_01464 5.1e-271 tagE3 2.4.1.52 GT4 M Glycosyl transferases group 1
HKDCBFDG_01465 8.7e-260 tagE2 2.4.1.52 GT4 M Poly(Glycerol-phosphate) alpha-glucosyltransferase
HKDCBFDG_01466 3e-148 metQ1 P Belongs to the nlpA lipoprotein family
HKDCBFDG_01467 2.6e-189 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HKDCBFDG_01468 1.2e-97 metI P ABC transporter permease
HKDCBFDG_01469 3.3e-19
HKDCBFDG_01470 2.1e-59
HKDCBFDG_01471 3.1e-75 uspA T universal stress protein
HKDCBFDG_01473 1.8e-128 qmcA O prohibitin homologues
HKDCBFDG_01474 5.5e-245 glpT G Major Facilitator Superfamily
HKDCBFDG_01475 0.0 tkt 2.2.1.1 H Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HKDCBFDG_01476 1.3e-134 tal 2.2.1.2 H Transaldolase/Fructose-6-phosphate aldolase
HKDCBFDG_01477 1.2e-260 S Uncharacterized protein conserved in bacteria (DUF2252)
HKDCBFDG_01478 2e-296 scrB 3.2.1.26 GH32 G invertase
HKDCBFDG_01479 1.2e-196 adhA 1.1.1.1 C Zinc-binding alcohol dehydrogenase family protein
HKDCBFDG_01480 0.0 scrA 2.7.1.211, 5.3.1.1 G phosphotransferase system
HKDCBFDG_01481 3.6e-108 ppiB 5.2.1.8 G PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HKDCBFDG_01482 8.7e-65 arsC 1.20.4.1 P Belongs to the ArsC family
HKDCBFDG_01483 3.6e-186 ybhR V ABC transporter
HKDCBFDG_01484 3.1e-125 ybhF_2 V AAA domain, putative AbiEii toxin, Type IV TA system
HKDCBFDG_01485 4.4e-92 K transcriptional regulator
HKDCBFDG_01486 2.8e-166 guaC 1.1.1.205, 1.7.1.7 F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
HKDCBFDG_01487 3e-248 purA 6.3.4.4 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HKDCBFDG_01488 2.1e-255 gabD 1.2.1.16, 1.2.1.20, 1.2.1.79 C Belongs to the aldehyde dehydrogenase family
HKDCBFDG_01489 0.0 FbpA K Fibronectin-binding protein
HKDCBFDG_01490 3.2e-161 degV S EDD domain protein, DegV family
HKDCBFDG_01491 4.6e-98
HKDCBFDG_01492 5.9e-132 S Belongs to the UPF0246 family
HKDCBFDG_01493 1.5e-118 ypgQ S Metal dependent phosphohydrolases with conserved 'HD' motif.
HKDCBFDG_01494 5.3e-113 ylbE GM NAD(P)H-binding
HKDCBFDG_01495 3.5e-99 K Acetyltransferase (GNAT) domain
HKDCBFDG_01496 5e-89 MA20_03535 1.1.1.399, 1.1.1.95 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HKDCBFDG_01497 2.5e-178 K helix_turn _helix lactose operon repressor
HKDCBFDG_01498 0.0 pepF E oligoendopeptidase F
HKDCBFDG_01499 5.4e-234 gltP U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
HKDCBFDG_01500 7e-124 S Membrane
HKDCBFDG_01501 2.4e-41 nreC K helix_turn_helix, Lux Regulon
HKDCBFDG_01502 5.1e-62 S membrane transporter protein
HKDCBFDG_01503 1.4e-112 K Helix-turn-helix domain
HKDCBFDG_01504 1.6e-155 ttdA 4.2.1.32 C Fumarate hydratase (Fumerase)
HKDCBFDG_01505 6.4e-100 ttdB 4.2.1.2, 4.2.1.32 C Catalyzes the reversible hydration of fumarate to (S)- malate
HKDCBFDG_01506 2.4e-92 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
HKDCBFDG_01507 1.2e-95 P Sodium:sulfate symporter transmembrane region
HKDCBFDG_01508 0.0 norZ 1.7.2.5 P Cytochrome C and Quinol oxidase polypeptide I
HKDCBFDG_01509 0.0 pacL 3.6.3.8, 3.6.3.9 P Cation transporter/ATPase, N-terminus
HKDCBFDG_01510 2.8e-164 K AI-2E family transporter
HKDCBFDG_01511 0.0 fhs 6.3.4.3 F Belongs to the formate--tetrahydrofolate ligase family
HKDCBFDG_01512 1.8e-81 purE 5.4.99.18 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HKDCBFDG_01513 3.2e-214 purK 6.3.4.18 F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HKDCBFDG_01514 1.2e-254 purB 4.3.2.2 F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HKDCBFDG_01515 0.0 valS 6.1.1.9 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
HKDCBFDG_01516 1.6e-88 tpx 1.11.1.15 O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HKDCBFDG_01517 3e-10
HKDCBFDG_01518 2.5e-23 S zinc-ribbon domain
HKDCBFDG_01519 9.1e-26
HKDCBFDG_01520 9.7e-194 adhP 1.1.1.1 C alcohol dehydrogenase
HKDCBFDG_01521 1.1e-132 XK27_07210 6.1.1.6 S B3 4 domain
HKDCBFDG_01522 4.2e-121 J 2'-5' RNA ligase superfamily
HKDCBFDG_01524 1.8e-53 S ABC-type cobalt transport system, permease component
HKDCBFDG_01525 1.1e-147 uppP 3.6.1.27 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
HKDCBFDG_01526 1.3e-45 IQ reductase
HKDCBFDG_01527 2e-11 IQ Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HKDCBFDG_01529 2.2e-148 ponA V Beta-lactamase enzyme family
HKDCBFDG_01530 1.4e-265 yjeM E Amino Acid
HKDCBFDG_01532 3.9e-110
HKDCBFDG_01533 6.8e-164 S Polyphosphate nucleotide phosphotransferase, PPK2 family
HKDCBFDG_01534 2.7e-163 K LysR substrate binding domain
HKDCBFDG_01535 4.3e-18 K HxlR-like helix-turn-helix
HKDCBFDG_01536 1.6e-30 IQ Dehydrogenase
HKDCBFDG_01537 1.1e-94 nagZ 3.2.1.52 G Glycosyl hydrolase family 3 N terminal domain
HKDCBFDG_01538 4e-231 S response to antibiotic
HKDCBFDG_01539 9.7e-170 hrpQ 4.6.1.1 T histone H2A K63-linked ubiquitination
HKDCBFDG_01540 0.0 asnB 6.3.5.4 E Aluminium induced protein
HKDCBFDG_01541 9.8e-18 hbd2 1.1.1.157 I 3-hydroxyacyl-CoA dehydrogenase
HKDCBFDG_01542 3e-14
HKDCBFDG_01543 2.2e-182 scrR3 K Transcriptional regulator, LacI family
HKDCBFDG_01544 3.8e-78 F Nucleoside 2-deoxyribosyltransferase
HKDCBFDG_01545 9.1e-86
HKDCBFDG_01548 1.4e-189 trpS 6.1.1.2 J Belongs to the class-I aminoacyl-tRNA synthetase family
HKDCBFDG_01550 5.7e-224 glnP P ABC transporter
HKDCBFDG_01551 1e-136 glnQ 3.6.3.21 E ABC transporter, ATP-binding protein
HKDCBFDG_01552 1.2e-246 yxbA 6.3.1.12 S ATP-grasp enzyme
HKDCBFDG_01553 1.1e-161 EG EamA-like transporter family
HKDCBFDG_01554 2.3e-134 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HKDCBFDG_01555 1.4e-141 manA 1.14.13.81, 5.3.1.8, 5.4.2.8 G MucBP domain
HKDCBFDG_01556 1.7e-97 S Pfam:DUF3816
HKDCBFDG_01557 8.5e-46 citE 4.1.3.25, 4.1.3.34 G Belongs to the HpcH HpaI aldolase family
HKDCBFDG_01558 1.1e-84 citE 4.1.3.25, 4.1.3.34 G Belongs to the HpcH HpaI aldolase family
HKDCBFDG_01559 3.2e-80 citF 2.8.3.10 H Citrate (pro-3S)-lyase alpha chain
HKDCBFDG_01560 7.8e-148 citF 2.8.3.10 H Citrate (pro-3S)-lyase alpha chain
HKDCBFDG_01561 4.5e-67 citG 2.4.2.52, 2.7.7.61 H 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase
HKDCBFDG_01562 4.3e-48 citG 2.4.2.52, 2.7.7.61 H 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase
HKDCBFDG_01563 6.1e-71 ydjP I Alpha/beta hydrolase family
HKDCBFDG_01564 2.1e-83 P Cadmium resistance transporter
HKDCBFDG_01565 3.2e-116 S Protein of unknown function (DUF554)
HKDCBFDG_01566 4.2e-103 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HKDCBFDG_01567 7.1e-158 P Belongs to the nlpA lipoprotein family
HKDCBFDG_01568 5.6e-97 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HKDCBFDG_01569 2.3e-08
HKDCBFDG_01570 3.6e-105 S Domain of unknown function (DUF4767)
HKDCBFDG_01571 4.7e-54 K Helix-turn-helix domain
HKDCBFDG_01572 3.9e-173 1.3.1.9 S Nitronate monooxygenase
HKDCBFDG_01573 6.2e-80 rocF 3.5.3.1, 3.5.3.11 E Arginase family
HKDCBFDG_01574 1.4e-50 ybjQ S Belongs to the UPF0145 family
HKDCBFDG_01575 9.3e-73 dxs 2.2.1.7 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HKDCBFDG_01576 4.6e-137 E GDSL-like Lipase/Acylhydrolase family
HKDCBFDG_01577 3e-124 C nitroreductase
HKDCBFDG_01578 1.1e-175 rihA 3.2.2.1 F Inosine-uridine preferring nucleoside hydrolase
HKDCBFDG_01579 2.9e-120 arcC 2.7.2.2 E Amino acid kinase family
HKDCBFDG_01582 4.3e-41 sucD 6.2.1.5 C Protein of unknown function (DUF1116)
HKDCBFDG_01583 1.9e-217 G Transporter, major facilitator family protein
HKDCBFDG_01584 1.1e-272 menE 6.2.1.26 H Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily
HKDCBFDG_01585 5.3e-158 menB 4.1.3.36 H Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HKDCBFDG_01586 1.9e-62 ydiI Q Thioesterase superfamily
HKDCBFDG_01587 1.4e-170 corA P CorA-like Mg2+ transporter protein
HKDCBFDG_01588 4.6e-168 rluA 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
HKDCBFDG_01589 2.3e-142 terC P membrane
HKDCBFDG_01590 1e-56 trxA1 O Belongs to the thioredoxin family
HKDCBFDG_01591 3e-143 isdH M Iron Transport-associated domain
HKDCBFDG_01592 1.4e-94 M Iron Transport-associated domain
HKDCBFDG_01593 1.1e-148 isdE P Periplasmic binding protein
HKDCBFDG_01594 1.6e-150 isdF U Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKDCBFDG_01595 1.3e-139 fhuC 3.6.3.34 HP ABC transporter, ATP-binding protein
HKDCBFDG_01596 1.2e-112 jag S R3H domain protein
HKDCBFDG_01597 5.6e-253 mnmE S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HKDCBFDG_01598 0.0 gidA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
HKDCBFDG_01600 4.7e-29 S Domain of unknown function (DUF4767)
HKDCBFDG_01601 7e-44 S Tautomerase enzyme
HKDCBFDG_01603 1.7e-119 pnb C nitroreductase
HKDCBFDG_01604 2.8e-182 argE 3.5.1.16 E Acetylornithine deacetylase
HKDCBFDG_01605 4e-34 M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HKDCBFDG_01606 4.2e-11 S integral membrane protein
HKDCBFDG_01607 2e-12 S integral membrane protein
HKDCBFDG_01608 3e-184 fruR3 K Transcriptional regulator, LacI family
HKDCBFDG_01609 1.4e-161 glxR 1.1.1.31, 1.1.1.60 I Dehydrogenase
HKDCBFDG_01610 2.6e-166 rbsK 2.7.1.15 H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKDCBFDG_01611 1.2e-208 hpk31 2.7.13.3 T Histidine kinase
HKDCBFDG_01612 1e-122 K response regulator
HKDCBFDG_01613 1.6e-131 gpmA 5.4.2.11 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HKDCBFDG_01614 2.3e-223 patA 2.6.1.1, 2.6.1.57 E Aminotransferase
HKDCBFDG_01615 1.3e-177
HKDCBFDG_01616 1.7e-201 I transferase activity, transferring acyl groups other than amino-acyl groups
HKDCBFDG_01618 2.8e-85 padC Q Phenolic acid decarboxylase
HKDCBFDG_01619 4.1e-98 padR K Virulence activator alpha C-term
HKDCBFDG_01620 6.4e-78 ndk 2.7.4.6 F Belongs to the NDK family
HKDCBFDG_01621 8.9e-170 rfbB 4.2.1.46 M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
HKDCBFDG_01622 2.3e-63 gntR1 K Transcriptional regulator, GntR family
HKDCBFDG_01623 1.6e-157 V ABC transporter, ATP-binding protein
HKDCBFDG_01624 1.2e-14
HKDCBFDG_01625 2e-216 argE 3.5.1.18 E succinyl-diaminopimelate desuccinylase
HKDCBFDG_01626 1.3e-294 cadA P P-type ATPase
HKDCBFDG_01627 1e-91 P Cadmium resistance transporter
HKDCBFDG_01628 1.1e-28 C Aldo/keto reductase family
HKDCBFDG_01631 7.8e-85 C Aldo keto reductase
HKDCBFDG_01632 1.4e-78 S Belongs to the short-chain dehydrogenases reductases (SDR) family
HKDCBFDG_01633 1.2e-274 gnd 1.1.1.343, 1.1.1.44 H Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HKDCBFDG_01634 1e-81 uspA T universal stress protein
HKDCBFDG_01635 9.6e-46 leuB 1.1.1.85 CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
HKDCBFDG_01636 3.5e-279 leuC 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HKDCBFDG_01637 1.7e-105 leuD 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HKDCBFDG_01638 1.8e-104 ahpC 1.11.1.15 O Peroxiredoxin
HKDCBFDG_01639 0.0 trxB2 1.8.1.9 C Thioredoxin domain
HKDCBFDG_01640 1.9e-95 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HKDCBFDG_01641 1.4e-130 pyrF 4.1.1.23 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
HKDCBFDG_01642 9.4e-115 pyrE 2.4.2.10, 4.1.1.23 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HKDCBFDG_01643 4e-17 gntT EG gluconate transmembrane transporter activity
HKDCBFDG_01644 4.8e-158 C C4-dicarboxylate transmembrane transporter activity
HKDCBFDG_01645 3.5e-60 kguE 2.7.1.45 G Xylose isomerase domain protein TIM barrel
HKDCBFDG_01646 2.8e-63 yjbR S YjbR
HKDCBFDG_01647 6.1e-117 S Sel1-like repeats.
HKDCBFDG_01648 3.6e-89 K Psort location CytoplasmicMembrane, score
HKDCBFDG_01649 7.2e-21 2.3.1.15 D Antitoxin component of a toxin-antitoxin (TA) module
HKDCBFDG_01650 2.1e-23 D mRNA cleavage
HKDCBFDG_01651 9.7e-179 S Phosphotransferase system, EIIC
HKDCBFDG_01653 2.1e-77 aes I Hydrolase, alpha beta domain protein
HKDCBFDG_01656 1.6e-168 scrK 2.7.1.2, 2.7.1.4 GK ROK family
HKDCBFDG_01657 7e-173 mepA V MATE efflux family protein
HKDCBFDG_01658 2.1e-51 S Sugar efflux transporter for intercellular exchange
HKDCBFDG_01659 4.3e-56 1.14.99.57 S Antibiotic biosynthesis monooxygenase
HKDCBFDG_01660 1.3e-57 ywrO S Flavodoxin-like fold
HKDCBFDG_01661 9e-26 ywrO S Flavodoxin-like fold
HKDCBFDG_01662 4.2e-08 isdH M Iron Transport-associated domain
HKDCBFDG_01664 2.9e-100 copA 3.6.3.54 P P-type ATPase
HKDCBFDG_01665 1.5e-27 EGP Major facilitator Superfamily
HKDCBFDG_01666 4.7e-90 2.4.2.6 F nucleoside 2-deoxyribosyltransferase
HKDCBFDG_01667 2.3e-16 S ABC-type transport system involved in multi-copper enzyme maturation permease component
HKDCBFDG_01668 2e-52 T Transcriptional regulatory protein, C terminal
HKDCBFDG_01669 2.9e-25 T His Kinase A (phosphoacceptor) domain
HKDCBFDG_01670 5.8e-112 ybbL S ABC transporter, ATP-binding protein
HKDCBFDG_01671 7.6e-310 araB 2.7.1.12, 2.7.1.16, 2.7.1.17 G carbohydrate kinase FGGY
HKDCBFDG_01673 2.4e-101 K DNA-templated transcription, initiation
HKDCBFDG_01674 5.8e-27 lytE M LysM domain protein
HKDCBFDG_01675 1.1e-84 ykhA 3.1.2.20 I Thioesterase superfamily
HKDCBFDG_01676 2e-76 hsp O Belongs to the small heat shock protein (HSP20) family
HKDCBFDG_01677 9.5e-53
HKDCBFDG_01678 3.7e-221 iscS 2.8.1.7 E Aminotransferase class V
HKDCBFDG_01679 1.4e-251 cycA E Amino acid permease
HKDCBFDG_01680 2.5e-46 silP 1.9.3.1, 3.6.3.54 S Cupredoxin-like domain
HKDCBFDG_01681 3.3e-52 silP 1.9.3.1, 3.6.3.54 S Cupredoxin-like domain
HKDCBFDG_01682 2e-230 cfa 2.1.1.317, 2.1.1.79 M cyclopropane-fatty-acyl-phospholipid synthase
HKDCBFDG_01683 2.4e-121 ribA 3.5.4.25, 4.1.99.12 H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HKDCBFDG_01684 2.6e-236 kgtP EGP Sugar (and other) transporter
HKDCBFDG_01686 7.6e-180 1.1.1.26 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HKDCBFDG_01687 7.3e-113 glpQ1 3.1.4.46 C glycerophosphoryl diester phosphodiesterase
HKDCBFDG_01688 3.5e-57 arsC 1.20.4.1 T Low molecular weight phosphotyrosine protein phosphatase
HKDCBFDG_01689 1.2e-60 azlD S branched-chain amino acid
HKDCBFDG_01690 2e-139 azlC E AzlC protein
HKDCBFDG_01691 7.9e-108 L Integrase
HKDCBFDG_01692 2.8e-44 K transcriptional regulator
HKDCBFDG_01693 1.4e-113 adh 1.1.1.1, 1.1.1.14 C Zinc-binding dehydrogenase
HKDCBFDG_01694 4.2e-74 O OsmC-like protein
HKDCBFDG_01695 1.1e-74 paiA 2.3.1.57 K Acetyltransferase (GNAT) domain
HKDCBFDG_01696 2.7e-12 EGP Major Facilitator Superfamily
HKDCBFDG_01699 9.5e-236 N Uncharacterized conserved protein (DUF2075)
HKDCBFDG_01700 1.2e-119 tkt 2.2.1.1 H Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HKDCBFDG_01701 4.9e-159 xth 3.1.11.2 L exodeoxyribonuclease III
HKDCBFDG_01702 5.6e-102 pucG 2.6.1.112, 2.6.1.44, 2.6.1.45, 2.6.1.51 E Aminotransferase class-V
HKDCBFDG_01703 5.8e-18 pucG 2.6.1.112, 2.6.1.44, 2.6.1.45, 2.6.1.51 E COG0075 Serine-pyruvate aminotransferase archaeal aspartate aminotransferase
HKDCBFDG_01704 4.3e-176 fecB P Periplasmic binding protein
HKDCBFDG_01705 2.8e-32 gltB 1.4.1.13, 1.4.1.14, 1.4.7.1, 2.1.1.21 E GXGXG motif
HKDCBFDG_01706 6.5e-67 ydjE EGP Major facilitator Superfamily
HKDCBFDG_01708 1.3e-15 citG 2.4.2.52, 2.7.7.61 H 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase
HKDCBFDG_01709 2.4e-139 C The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated

eggNOG-mapper v2 (Database: eggNOG v5.0, Jul. 2018 release)