ORF_ID e_value Gene_name EC_number CAZy COGs Description
HMLCPHOH_00005 7.8e-08
HMLCPHOH_00013 2e-08
HMLCPHOH_00017 2.7e-143 spo0M S COG4326 Sporulation control protein
HMLCPHOH_00018 3e-27
HMLCPHOH_00019 5.9e-134 pepE 3.4.11.2, 3.4.13.21 E Belongs to the peptidase S51 family
HMLCPHOH_00020 0.0 thiC 4.1.99.17 H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HMLCPHOH_00021 1.9e-266 ygaK C Berberine and berberine like
HMLCPHOH_00023 3.2e-291 katA 1.11.1.6 P serves to protect cells from the toxic effects of hydrogen peroxide
HMLCPHOH_00024 1.1e-145 ssuB P COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component
HMLCPHOH_00025 1.7e-171 ssuA M Sulfonate ABC transporter
HMLCPHOH_00026 1.5e-147 ssuC P COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component
HMLCPHOH_00027 3.1e-217 ssuD 1.14.14.5 C Catalyzes the desulfonation of aliphatic sulfonates
HMLCPHOH_00029 6e-42 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HMLCPHOH_00030 4.1e-78 ygaO
HMLCPHOH_00031 4.4e-29 K Transcriptional regulator
HMLCPHOH_00033 7.9e-114 yhzB S B3/4 domain
HMLCPHOH_00034 2.1e-224 queG 1.17.99.6 C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HMLCPHOH_00035 4.4e-177 yhbB S Putative amidase domain
HMLCPHOH_00036 8.2e-87 trmL 2.1.1.207 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
HMLCPHOH_00037 1.2e-109 yhbD K Protein of unknown function (DUF4004)
HMLCPHOH_00038 1.6e-65 yhbE M COG1664 Integral membrane protein CcmA involved in cell shape determination
HMLCPHOH_00039 8.2e-75 yhbF M COG1664 Integral membrane protein CcmA involved in cell shape determination
HMLCPHOH_00040 0.0 prkA T Ser protein kinase
HMLCPHOH_00041 2.5e-225 yhbH S Belongs to the UPF0229 family
HMLCPHOH_00042 2.2e-76 yhbI K DNA-binding transcription factor activity
HMLCPHOH_00043 3.1e-97 yhbJ V COG1566 Multidrug resistance efflux pump
HMLCPHOH_00044 3.1e-271 yhcA EGP Major facilitator Superfamily
HMLCPHOH_00045 1e-98 yhcB 1.6.5.2 S Belongs to the WrbA family
HMLCPHOH_00046 2.8e-37 yhcC
HMLCPHOH_00047 7.8e-55
HMLCPHOH_00048 6.6e-60 yhcF K Transcriptional regulator
HMLCPHOH_00049 1.6e-123 yhcG V ABC transporter, ATP-binding protein
HMLCPHOH_00050 2.6e-166 yhcH V ABC transporter, ATP-binding protein
HMLCPHOH_00051 3.9e-165 yhcI S COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
HMLCPHOH_00052 1e-30 cspB K Cold-shock protein
HMLCPHOH_00053 5.2e-153 metQ M Belongs to the nlpA lipoprotein family
HMLCPHOH_00054 1.2e-197 yhcK 2.7.7.65 T COG2199 FOG GGDEF domain
HMLCPHOH_00055 6.3e-220 ydjN U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
HMLCPHOH_00056 3.7e-44 yhcM
HMLCPHOH_00057 2.1e-68 yhcN S Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
HMLCPHOH_00058 4.8e-166 yhcP
HMLCPHOH_00059 5.2e-100 yhcQ M Spore coat protein
HMLCPHOH_00060 0.0 yhcR 3.1.3.5, 3.1.31.1 F Belongs to the 5'-nucleotidase family
HMLCPHOH_00061 7.6e-106 yhcS 3.4.22.70 M COG3764 Sortase (surface protein transpeptidase)
HMLCPHOH_00062 7.9e-171 rluA 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
HMLCPHOH_00063 9.3e-68 yhcU S Family of unknown function (DUF5365)
HMLCPHOH_00064 9.9e-68 yhcV S COG0517 FOG CBS domain
HMLCPHOH_00065 4.6e-120 yhcW 5.4.2.6 S hydrolase
HMLCPHOH_00066 2.7e-304 yhcX 3.5.1.3 K Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
HMLCPHOH_00067 1.1e-261 yhxA E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HMLCPHOH_00068 5.2e-104 glpP K Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HMLCPHOH_00069 1.9e-152 glpF G Belongs to the MIP aquaporin (TC 1.A.8) family
HMLCPHOH_00070 4.6e-293 glpK 2.7.1.30 C Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HMLCPHOH_00071 0.0 glpD 1.1.5.3 C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HMLCPHOH_00072 0.0 pmmB 5.4.2.2, 5.4.2.8 G Phosphoglucomutase
HMLCPHOH_00073 5.5e-214 yhcY 2.7.13.3 T Histidine kinase
HMLCPHOH_00074 1.1e-113 yhcZ K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HMLCPHOH_00075 1.4e-84 azr 1.7.1.6 S NADPH-dependent FMN reductase
HMLCPHOH_00076 1.2e-38 yhdB S YhdB-like protein
HMLCPHOH_00077 4.8e-54 yhdC S Protein of unknown function (DUF3889)
HMLCPHOH_00078 7.9e-189 cwlS 3.5.1.28 CBM50 M COG1388 FOG LysM repeat
HMLCPHOH_00079 3.5e-76 nsrR K Transcriptional regulator
HMLCPHOH_00080 8.7e-239 ygxB M Conserved TM helix
HMLCPHOH_00081 2.1e-276 ycgB S Stage V sporulation protein R
HMLCPHOH_00082 5.8e-258 phoB 3.1.3.1 P Belongs to the alkaline phosphatase family
HMLCPHOH_00083 2.5e-141 lytE 3.5.1.28 CBM50 M COG1388 FOG LysM repeat
HMLCPHOH_00084 3.8e-162 citR K Transcriptional regulator
HMLCPHOH_00085 1.4e-206 citA 2.3.3.1 C Belongs to the citrate synthase family
HMLCPHOH_00086 4.9e-162 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HMLCPHOH_00087 3.4e-250 yhdG E amino acid
HMLCPHOH_00088 1.5e-242 yhdH S Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
HMLCPHOH_00089 3.7e-276 ydeL K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
HMLCPHOH_00090 6.9e-77 BH1582 K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HMLCPHOH_00091 8.1e-45 yhdK S Sigma-M inhibitor protein
HMLCPHOH_00092 6.6e-201 yhdL S Sigma factor regulator N-terminal
HMLCPHOH_00093 5.5e-86 sigM K Belongs to the sigma-70 factor family. ECF subfamily
HMLCPHOH_00094 1.5e-191 yhdN C Aldo keto reductase
HMLCPHOH_00095 3e-110 plsC 2.3.1.51 I Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family
HMLCPHOH_00096 3.1e-240 corC1 S COG1253 Hemolysins and related proteins containing CBS domains
HMLCPHOH_00097 4.1e-74 cueR K transcriptional
HMLCPHOH_00098 1.4e-223 yhdR 2.6.1.1 E Aminotransferase
HMLCPHOH_00099 1.1e-240 corC1 P COG1253 Hemolysins and related proteins containing CBS domains
HMLCPHOH_00100 2.8e-47 crcB D Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HMLCPHOH_00101 5.1e-66 crcB D Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HMLCPHOH_00102 3.3e-135 yhdW 3.1.4.46 C glycerophosphoryl diester phosphodiesterase
HMLCPHOH_00104 6.6e-204 yhdY M Mechanosensitive ion channel
HMLCPHOH_00105 1.2e-140 cobB K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form
HMLCPHOH_00106 1.7e-151 yheN G deacetylase
HMLCPHOH_00107 1.1e-153 dat 2.6.1.21 E Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha- keto acid in the first half-reaction
HMLCPHOH_00108 2.2e-233 nhaC C Na H antiporter
HMLCPHOH_00109 3.4e-84 nhaX T Belongs to the universal stress protein A family
HMLCPHOH_00110 0.0 yheI V COG1132 ABC-type multidrug transport system, ATPase and permease components
HMLCPHOH_00111 0.0 yheH V COG1132 ABC-type multidrug transport system, ATPase and permease components
HMLCPHOH_00112 3.7e-111 yheG GM NAD(P)H-binding
HMLCPHOH_00113 6.3e-28 sspB S spore protein
HMLCPHOH_00114 1.3e-36 yheE S Family of unknown function (DUF5342)
HMLCPHOH_00115 1.6e-268 gshB 6.3.2.2, 6.3.2.3 HJ YheC/D like ATP-grasp
HMLCPHOH_00116 4.3e-216 yheC HJ YheC/D like ATP-grasp
HMLCPHOH_00117 6.7e-204 yheB S Belongs to the UPF0754 family
HMLCPHOH_00118 9.5e-48 yheA S Belongs to the UPF0342 family
HMLCPHOH_00119 3.1e-206 yhaZ L DNA alkylation repair enzyme
HMLCPHOH_00120 4.3e-142 yhaX S haloacid dehalogenase-like hydrolase
HMLCPHOH_00121 7.1e-294 hemZ H coproporphyrinogen III oxidase
HMLCPHOH_00122 1.7e-208 yhaU P COG0475 Kef-type K transport systems, membrane components
HMLCPHOH_00123 7.8e-88 yhaT P regulatory, ligand-binding protein related to C-terminal domains of K channels
HMLCPHOH_00125 1.9e-133 yhaR 5.3.3.18 I enoyl-CoA hydratase
HMLCPHOH_00126 1.1e-26 S YhzD-like protein
HMLCPHOH_00127 1.8e-167 yhaQ S ABC transporter, ATP-binding protein
HMLCPHOH_00128 4.2e-215 yhaP CP COG1668 ABC-type Na efflux pump, permease component
HMLCPHOH_00129 3.6e-227 yhaO L DNA repair exonuclease
HMLCPHOH_00130 0.0 yhaN L AAA domain
HMLCPHOH_00131 1.5e-177 yhaM L Shows a 3'-5' exoribonuclease activity
HMLCPHOH_00132 1.6e-21 yhaL S Sporulation protein YhaL
HMLCPHOH_00133 1.9e-121 prsA 5.2.1.8 M plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins
HMLCPHOH_00134 8.7e-90 yhaK S Putative zincin peptidase
HMLCPHOH_00135 1.3e-54 yhaI S Protein of unknown function (DUF1878)
HMLCPHOH_00136 1e-113 hpr K Negative regulator of protease production and sporulation
HMLCPHOH_00137 7e-39 yhaH S YtxH-like protein
HMLCPHOH_00138 3.6e-80 trpP S Tryptophan transporter TrpP
HMLCPHOH_00139 9.9e-205 serC 2.6.1.52 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HMLCPHOH_00140 4.7e-81 hit FG COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
HMLCPHOH_00141 4.6e-137 ecsA V transporter (ATP-binding protein)
HMLCPHOH_00142 1.8e-215 ecsB U ABC transporter
HMLCPHOH_00143 4.8e-115 ecsC S EcsC protein family
HMLCPHOH_00144 2.3e-231 yhaA 3.5.1.47 E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
HMLCPHOH_00145 4.2e-248 yhfA C membrane
HMLCPHOH_00146 7.5e-17 1.15.1.2 C Rubrerythrin
HMLCPHOH_00147 1.3e-90 traP 1.14.99.57, 6.2.1.3 S enzyme involved in biosynthesis of extracellular polysaccharides
HMLCPHOH_00148 0.0 pbpF 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
HMLCPHOH_00149 1.7e-204 hemE 4.1.1.37 H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HMLCPHOH_00150 7.3e-180 hemH 4.99.1.1, 4.99.1.9 H Catalyzes the ferrous insertion into protoporphyrin IX
HMLCPHOH_00151 1.7e-268 hemG 1.14.19.9, 1.3.3.15, 1.3.3.4 H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HMLCPHOH_00152 1.4e-101 yhgD K Transcriptional regulator
HMLCPHOH_00153 1e-238 yhgE S YhgE Pip N-terminal domain protein
HMLCPHOH_00154 3e-184 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HMLCPHOH_00155 9.8e-138 yhfC S Putative membrane peptidase family (DUF2324)
HMLCPHOH_00156 1.6e-199 yhfE 3.2.1.4 GH5,GH9 G peptidase M42
HMLCPHOH_00157 1.7e-72 3.4.13.21 S ASCH
HMLCPHOH_00158 3.8e-227 gltP C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
HMLCPHOH_00159 1.8e-141 yhfI S COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III
HMLCPHOH_00160 2e-191 lplJ 6.3.1.20 H Lipoate-protein ligase
HMLCPHOH_00161 2.6e-112 yhfK GM NmrA-like family
HMLCPHOH_00162 7.3e-302 fadD 6.2.1.3 IQ AMP-binding enzyme C-terminal domain
HMLCPHOH_00163 1.9e-65 yhfM
HMLCPHOH_00164 5.4e-242 yhfN 3.4.24.84 O Peptidase M48
HMLCPHOH_00165 2.3e-204 aprE 3.4.21.62 O Belongs to the peptidase S8 family
HMLCPHOH_00166 9.2e-80 VY92_01935 K acetyltransferase
HMLCPHOH_00167 8.3e-182 yhfP 1.1.1.1 C Quinone oxidoreductase
HMLCPHOH_00168 4.3e-159 yfmC M Periplasmic binding protein
HMLCPHOH_00169 1.9e-109 yhfR 3.1.3.73 G Belongs to the phosphoglycerate mutase family
HMLCPHOH_00170 2.3e-201 vraB 2.3.1.9 I Belongs to the thiolase family
HMLCPHOH_00171 1e-281 yhfT 6.2.1.3 IQ AMP-binding enzyme C-terminal domain
HMLCPHOH_00172 5e-91 bioY S BioY family
HMLCPHOH_00173 1.7e-182 hemAT NT chemotaxis protein
HMLCPHOH_00174 1.1e-302 yhfW CE COG0665 Glycine D-amino acid oxidases (deaminating)
HMLCPHOH_00175 1.6e-157 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HMLCPHOH_00176 1.3e-32 yhzC S IDEAL
HMLCPHOH_00177 4.2e-109 comK K Competence transcription factor
HMLCPHOH_00178 2.1e-168 IQ Enoyl-(Acyl carrier protein) reductase
HMLCPHOH_00179 7.8e-42 yhjA S Excalibur calcium-binding domain
HMLCPHOH_00180 6.1e-266 yhjB E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HMLCPHOH_00181 6.9e-27 yhjC S Protein of unknown function (DUF3311)
HMLCPHOH_00182 5e-60 yhjD
HMLCPHOH_00183 9.1e-110 yhjE S SNARE associated Golgi protein
HMLCPHOH_00184 1.2e-91 sipV 3.4.21.89 U Belongs to the peptidase S26 family
HMLCPHOH_00185 1.1e-286 yhjG CH FAD binding domain
HMLCPHOH_00186 1.2e-94 yhjH K helix_turn_helix multiple antibiotic resistance protein
HMLCPHOH_00187 6.9e-215 glcP G Major Facilitator Superfamily
HMLCPHOH_00188 1.1e-200 thuB 1.1.1.361 S Oxidoreductase family, C-terminal alpha/beta domain
HMLCPHOH_00189 1.8e-161 ntdB 3.1.3.92 S Sucrose-6F-phosphate phosphohydrolase
HMLCPHOH_00190 4.4e-255 ntdA 2.6.1.104 E Belongs to the DegT DnrJ EryC1 family
HMLCPHOH_00191 1.6e-188 yhjM 5.1.1.1 K Transcriptional regulator
HMLCPHOH_00192 3.8e-202 abrB S membrane
HMLCPHOH_00193 3.1e-215 EGP Transmembrane secretion effector
HMLCPHOH_00194 0.0 S Sugar transport-related sRNA regulator N-term
HMLCPHOH_00195 2e-36 yhjQ C COG1145 Ferredoxin
HMLCPHOH_00196 2.2e-78 yhjR S Rubrerythrin
HMLCPHOH_00197 0.0 addB 3.1.21.3, 3.6.4.12 L ATP-dependent helicase deoxyribonuclease subunit B
HMLCPHOH_00198 0.0 addA 3.6.4.12 L ATP-dependent helicase nuclease subunit A
HMLCPHOH_00199 1.7e-221 sbcD L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
HMLCPHOH_00200 0.0 sbcC L COG0419 ATPase involved in DNA repair
HMLCPHOH_00201 6e-51 yisB V COG1403 Restriction endonuclease
HMLCPHOH_00202 4.5e-32 gerPF S Spore germination protein gerPA/gerPF
HMLCPHOH_00203 3e-66 gerPE S Spore germination protein GerPE
HMLCPHOH_00204 6.3e-24 gerPD S Spore germination protein
HMLCPHOH_00205 1.8e-54 gerPC S Spore germination protein
HMLCPHOH_00206 4e-34 gerPB S cell differentiation
HMLCPHOH_00207 1.9e-33 gerPA S Spore germination protein
HMLCPHOH_00208 1.5e-22 yisI S Spo0E like sporulation regulatory protein
HMLCPHOH_00209 1.7e-176 cotH M Spore Coat
HMLCPHOH_00210 3.2e-172 yisK Q COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)
HMLCPHOH_00211 3e-57 yisL S UPF0344 protein
HMLCPHOH_00212 0.0 wprA O Belongs to the peptidase S8 family
HMLCPHOH_00213 7.2e-106 yisN S Protein of unknown function (DUF2777)
HMLCPHOH_00214 0.0 asnO 6.3.5.4 E Asparagine synthase
HMLCPHOH_00215 2.1e-88 yizA S Damage-inducible protein DinB
HMLCPHOH_00216 6.8e-150 crtB 2.5.1.21, 2.5.1.32, 2.5.1.99 I phytoene
HMLCPHOH_00217 8.9e-243 yisQ V Mate efflux family protein
HMLCPHOH_00218 1.2e-160 yisR K Transcriptional regulator
HMLCPHOH_00219 2.4e-184 purR K helix_turn _helix lactose operon repressor
HMLCPHOH_00220 4.5e-199 yisS 1.1.1.370 S Oxidoreductase family, C-terminal alpha/beta domain
HMLCPHOH_00221 1.3e-93 yisT S DinB family
HMLCPHOH_00222 6.4e-108 argO S Lysine exporter protein LysE YggA
HMLCPHOH_00223 1.7e-281 yisV K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
HMLCPHOH_00224 4e-36 mcbG S Pentapeptide repeats (9 copies)
HMLCPHOH_00225 3.1e-155 yisY I hydrolases or acyltransferases (alpha beta hydrolase superfamily)
HMLCPHOH_00226 4.9e-113 cysC 1.8.4.10, 1.8.4.8, 2.7.1.25, 2.7.7.4 P Catalyzes the synthesis of activated sulfate
HMLCPHOH_00227 3.2e-233 sat 2.7.7.4 P Belongs to the sulfate adenylyltransferase family
HMLCPHOH_00228 9.2e-143 cysH 1.8.4.10, 1.8.4.8, 2.7.1.25 EH Belongs to the PAPS reductase family. CysH subfamily
HMLCPHOH_00229 4.9e-125 comB 3.1.3.71 H Belongs to the ComB family
HMLCPHOH_00230 1.9e-141 yitD 4.4.1.19 S synthase
HMLCPHOH_00231 7.2e-113 yitE S Uncharacterised 5xTM membrane BCR, YitT family COG1284
HMLCPHOH_00232 5.4e-222 yitF 5.5.1.27 M Belongs to the mandelate racemase muconate lactonizing enzyme family
HMLCPHOH_00233 4e-229 yitG EGP Major facilitator Superfamily
HMLCPHOH_00234 1.8e-161 yitH K Acetyltransferase (GNAT) domain
HMLCPHOH_00235 5.8e-82 yjcF S Acetyltransferase (GNAT) domain
HMLCPHOH_00236 0.0 yitJ 1.5.1.20, 2.1.1.10, 2.1.1.13 E Catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine
HMLCPHOH_00237 8.6e-55 yajQ S Belongs to the UPF0234 family
HMLCPHOH_00238 4e-161 cvfB S protein conserved in bacteria
HMLCPHOH_00239 8.5e-94
HMLCPHOH_00240 2.8e-171
HMLCPHOH_00241 1.5e-97 S Sporulation delaying protein SdpA
HMLCPHOH_00242 1.5e-58 K Transcriptional regulator PadR-like family
HMLCPHOH_00243 2e-95
HMLCPHOH_00244 1.4e-44 yitR S Domain of unknown function (DUF3784)
HMLCPHOH_00245 2.2e-311 nprB 3.4.24.28 E Peptidase M4
HMLCPHOH_00246 8.4e-159 yitS S protein conserved in bacteria
HMLCPHOH_00247 6.6e-148 yitT S Uncharacterized protein conserved in bacteria (DUF2179)
HMLCPHOH_00248 1.9e-72 ipi S Intracellular proteinase inhibitor
HMLCPHOH_00249 1.2e-17 S Protein of unknown function (DUF3813)
HMLCPHOH_00250 1.9e-155 yitU 3.1.3.104 S hydrolases of the HAD superfamily
HMLCPHOH_00251 4.5e-143 yjfP S COG1073 Hydrolases of the alpha beta superfamily
HMLCPHOH_00252 4.7e-51 yitW S metal-sulfur cluster biosynthetic enzyme
HMLCPHOH_00253 1.5e-22 pilT S Proteolipid membrane potential modulator
HMLCPHOH_00254 4.3e-272 yitY C D-arabinono-1,4-lactone oxidase
HMLCPHOH_00255 1.7e-88 norB G Major Facilitator Superfamily
HMLCPHOH_00256 5.4e-200 argC 1.2.1.38 E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HMLCPHOH_00257 3.1e-231 argJ 2.3.1.1, 2.3.1.35, 2.7.2.8 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HMLCPHOH_00258 2.2e-137 argB 2.7.2.8 E Belongs to the acetylglutamate kinase family. ArgB subfamily
HMLCPHOH_00259 4.4e-219 argD 2.6.1.11, 2.6.1.17 E acetylornithine aminotransferase
HMLCPHOH_00260 3.9e-206 carA 6.3.5.5 F Carbamoyl-phosphate synthetase glutamine chain
HMLCPHOH_00261 0.0 carB 6.3.5.5 EF Carbamoyl-phosphate synthetase ammonia chain
HMLCPHOH_00262 3.8e-176 argF 2.1.3.3 E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HMLCPHOH_00263 9.5e-28 yjzC S YjzC-like protein
HMLCPHOH_00264 2.3e-16 yjzD S Protein of unknown function (DUF2929)
HMLCPHOH_00265 6.2e-142 yjaU I carboxylic ester hydrolase activity
HMLCPHOH_00266 7.3e-103 yjaV
HMLCPHOH_00267 1.1e-183 med S Transcriptional activator protein med
HMLCPHOH_00268 7.3e-26 comZ S ComZ
HMLCPHOH_00269 2.7e-22 yjzB
HMLCPHOH_00270 3.9e-173 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HMLCPHOH_00271 1.8e-234 fabF 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
HMLCPHOH_00272 7.8e-151 yjaZ O Zn-dependent protease
HMLCPHOH_00273 1.8e-184 appD P Belongs to the ABC transporter superfamily
HMLCPHOH_00274 6.5e-187 appF E Belongs to the ABC transporter superfamily
HMLCPHOH_00275 1.6e-251 appA E COG0747 ABC-type dipeptide transport system, periplasmic component
HMLCPHOH_00276 1.3e-171 oppB P COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMLCPHOH_00277 7.9e-163 appC EP COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMLCPHOH_00278 5e-147 yjbA S Belongs to the UPF0736 family
HMLCPHOH_00279 6.1e-185 trpS 6.1.1.2 J Tryptophanyl-tRNA synthetase
HMLCPHOH_00280 0.0 oppA E ABC transporter substrate-binding protein
HMLCPHOH_00281 2.7e-166 oppB P COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMLCPHOH_00282 7.7e-166 oppC EP COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMLCPHOH_00283 3e-198 oppD P Belongs to the ABC transporter superfamily
HMLCPHOH_00284 5.5e-172 oppF E Belongs to the ABC transporter superfamily
HMLCPHOH_00285 8.6e-196 yjbB EGP Major Facilitator Superfamily
HMLCPHOH_00286 6.9e-104 yjbC K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HMLCPHOH_00287 2.1e-67 spxA 1.20.4.1 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
HMLCPHOH_00288 6e-112 yjbE P Integral membrane protein TerC family
HMLCPHOH_00289 2.3e-116 mecA NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC
HMLCPHOH_00290 2.3e-223 yjbF S Competence protein
HMLCPHOH_00291 0.0 pepF E oligoendopeptidase F
HMLCPHOH_00292 1.8e-20
HMLCPHOH_00294 3.3e-169 yjbH Q dithiol-disulfide isomerase involved in polyketide biosynthesis
HMLCPHOH_00295 3.7e-72 yjbI S Bacterial-like globin
HMLCPHOH_00296 1.5e-87 yjbJ M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)
HMLCPHOH_00297 2.4e-101 yjbK S protein conserved in bacteria
HMLCPHOH_00298 7.1e-62 yjbL S Belongs to the UPF0738 family
HMLCPHOH_00299 2.6e-112 yjbM 2.7.6.5 S GTP pyrophosphokinase
HMLCPHOH_00300 2.1e-151 nadK 2.7.1.23 G Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HMLCPHOH_00301 9.5e-161 yjbO 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
HMLCPHOH_00302 3e-128 prpE 3.1.3.16, 3.6.1.41 T Asymmetrically hydrolyzes Ap4p to yield AMP and ATP
HMLCPHOH_00303 0.0 yjbQ P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
HMLCPHOH_00304 3.4e-137 tenA 3.5.99.2 K Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HMLCPHOH_00305 3.8e-108 tenI 2.5.1.3, 5.3.99.10 H Transcriptional regulator TenI
HMLCPHOH_00306 7.2e-219 thiO 1.4.3.19 E Glycine oxidase
HMLCPHOH_00307 3e-30 thiS H thiamine diphosphate biosynthetic process
HMLCPHOH_00308 1.5e-135 thiG 2.8.1.10 H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S
HMLCPHOH_00309 6e-188 thiF 2.7.7.73, 2.7.7.80 H COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
HMLCPHOH_00310 5.3e-150 thiD 2.5.1.3, 2.7.1.35, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Phosphomethylpyrimidine kinase
HMLCPHOH_00311 3.2e-141 fabI 1.3.1.10, 1.3.1.9 I Enoyl- acyl-carrier-protein reductase NADH
HMLCPHOH_00312 5.9e-54 yjbX S Spore coat protein
HMLCPHOH_00313 5.2e-83 cotZ S Spore coat protein
HMLCPHOH_00314 3.4e-96 cotY S Spore coat protein Z
HMLCPHOH_00315 6.4e-77 cotX S Spore Coat Protein X and V domain
HMLCPHOH_00316 3e-32 cotW
HMLCPHOH_00317 2.3e-55 cotV S Spore Coat Protein X and V domain
HMLCPHOH_00318 8.7e-57 yjcA S Protein of unknown function (DUF1360)
HMLCPHOH_00321 2.9e-38 spoVIF S Stage VI sporulation protein F
HMLCPHOH_00322 0.0 yjcD 3.6.4.12 L DNA helicase
HMLCPHOH_00323 1.7e-38
HMLCPHOH_00324 3e-72 yjcF S COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HMLCPHOH_00325 2.9e-93 yjcG J Belongs to the 2H phosphoesterase superfamily. YjcG family
HMLCPHOH_00326 1.8e-138 yjcH P COG2382 Enterochelin esterase and related enzymes
HMLCPHOH_00327 3.8e-215 metB 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
HMLCPHOH_00328 2.9e-218 metC 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
HMLCPHOH_00329 3.7e-99 rimJ 2.3.1.128 J Alanine acetyltransferase
HMLCPHOH_00330 1.1e-212 yjcL S Protein of unknown function (DUF819)
HMLCPHOH_00333 2.1e-190 S Putative amidase domain
HMLCPHOH_00334 2.6e-44 yjcN
HMLCPHOH_00337 8.5e-81 L Transposase
HMLCPHOH_00338 1.6e-72 yjcP
HMLCPHOH_00339 4.1e-49 S YjcQ protein
HMLCPHOH_00340 1.1e-92 yqaS L DNA packaging
HMLCPHOH_00341 2.2e-47 yjcS S Antibiotic biosynthesis monooxygenase
HMLCPHOH_00342 2.4e-141 IQ Enoyl-(Acyl carrier protein) reductase
HMLCPHOH_00344 0.0 manR 2.7.1.200, 2.7.1.202 GKT transcriptional antiterminator
HMLCPHOH_00345 0.0 manP 2.7.1.191, 2.7.1.202 G phosphotransferase system
HMLCPHOH_00346 6.7e-189 manA 5.3.1.8 G mannose-6-phosphate isomerase
HMLCPHOH_00347 4.8e-51 yjdF S Protein of unknown function (DUF2992)
HMLCPHOH_00348 2.5e-94 yjdG 2.3.1.128 J Acetyltransferase (GNAT) domain
HMLCPHOH_00350 8e-82 ybaK S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HMLCPHOH_00351 4.2e-29 S Domain of unknown function (DUF4177)
HMLCPHOH_00352 2.7e-52 yjdJ S Domain of unknown function (DUF4306)
HMLCPHOH_00353 3.3e-175 cyoE 2.5.1.141 O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
HMLCPHOH_00355 4.9e-265 xynD 3.5.1.104 G Polysaccharide deacetylase
HMLCPHOH_00356 5.5e-83 S Protein of unknown function (DUF2690)
HMLCPHOH_00357 1.1e-20 yjfB S Putative motility protein
HMLCPHOH_00358 1.6e-171 yjfC O Predicted Zn-dependent protease (DUF2268)
HMLCPHOH_00359 1.2e-45 T PhoQ Sensor
HMLCPHOH_00360 8.9e-104 yjgB S Domain of unknown function (DUF4309)
HMLCPHOH_00361 0.0 yjgC 1.17.1.10, 1.17.1.9 C formate dehydrogenase (NAD+) activity
HMLCPHOH_00362 4.3e-95 yjgD S Protein of unknown function (DUF1641)
HMLCPHOH_00363 8.7e-07 S Domain of unknown function (DUF4352)
HMLCPHOH_00364 2e-117 yjhB 3.6.1.13, 3.6.1.55 F ADP-ribose pyrophosphatase
HMLCPHOH_00366 3.8e-226 yjiB 1.14.13.154, 1.14.15.8 C Cytochrome P450
HMLCPHOH_00367 4.5e-219 oleD GT1 CG COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase
HMLCPHOH_00368 8.2e-30
HMLCPHOH_00369 1.2e-146 hemD 2.1.1.107, 4.2.1.75 H Uroporphyrinogen-III synthase
HMLCPHOH_00370 1.9e-122 ybbM S transport system, permease component
HMLCPHOH_00371 5.2e-136 pstB 3.6.3.27 P ATPases associated with a variety of cellular activities
HMLCPHOH_00372 1.8e-176 yjlA EG Putative multidrug resistance efflux transporter
HMLCPHOH_00373 2.8e-93 yjlB S Cupin domain
HMLCPHOH_00374 7.1e-66 yjlC S Protein of unknown function (DUF1641)
HMLCPHOH_00375 2.6e-219 yjlD 1.6.99.3 C NADH dehydrogenase
HMLCPHOH_00376 6.3e-284 uxaC 5.3.1.12 G glucuronate isomerase
HMLCPHOH_00377 5.8e-250 yjmB G symporter YjmB
HMLCPHOH_00378 3e-195 yjmC 1.1.1.350 C Belongs to the LDH2 MDH2 oxidoreductase family
HMLCPHOH_00379 1.6e-193 rspB 1.1.1.380 E Alcohol dehydrogenase GroES-like domain
HMLCPHOH_00380 4.7e-215 uxuA 4.2.1.8 G Catalyzes the dehydration of D-mannonate
HMLCPHOH_00381 2.3e-153 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
HMLCPHOH_00382 3.7e-227 exuT G Sugar (and other) transporter
HMLCPHOH_00383 2.3e-184 exuR K transcriptional
HMLCPHOH_00384 2.1e-287 uxaB 1.1.1.17, 1.1.1.58 G tagaturonate reductase activity
HMLCPHOH_00385 2e-288 uxaA 4.2.1.7, 4.4.1.24 G Altronate
HMLCPHOH_00386 4.3e-130 MA20_18170 S membrane transporter protein
HMLCPHOH_00387 3.3e-80 yjoA S DinB family
HMLCPHOH_00388 9.4e-247 ftsH2 3.4.21.53 O AAA domain (dynein-related subfamily)
HMLCPHOH_00389 2.1e-213 S response regulator aspartate phosphatase
HMLCPHOH_00391 6.3e-41 S YCII-related domain
HMLCPHOH_00392 2e-169 xlyA 3.5.1.28 CBM50 M N-acetylmuramoyl-L-alanine amidase
HMLCPHOH_00393 2.1e-61 yjqA S Bacterial PH domain
HMLCPHOH_00394 4.2e-112 yjqB S Pfam:DUF867
HMLCPHOH_00395 4.4e-160 ydbD P Catalase
HMLCPHOH_00396 1.6e-111 xkdA E IrrE N-terminal-like domain
HMLCPHOH_00397 3.2e-56 xre K Helix-turn-helix XRE-family like proteins
HMLCPHOH_00399 5.9e-157 xkdB K sequence-specific DNA binding
HMLCPHOH_00400 6.4e-119 xkdC L Bacterial dnaA protein
HMLCPHOH_00403 4.6e-10 yqaO S Phage-like element PBSX protein XtrA
HMLCPHOH_00404 4.4e-86 xpf K COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog
HMLCPHOH_00405 4.8e-140 xtmA L phage terminase small subunit
HMLCPHOH_00406 9.6e-255 xtmB S phage terminase, large subunit
HMLCPHOH_00407 5.4e-286 yqbA S portal protein
HMLCPHOH_00408 1.2e-133 yqbD 2.1.1.72 L Putative phage serine protease XkdF
HMLCPHOH_00409 5.8e-169 xkdG S Phage capsid family
HMLCPHOH_00410 5.5e-65 yqbG S Protein of unknown function (DUF3199)
HMLCPHOH_00411 8.7e-65 yqbH S Domain of unknown function (DUF3599)
HMLCPHOH_00412 4.4e-88 xkdI S Bacteriophage HK97-gp10, putative tail-component
HMLCPHOH_00413 1.9e-77 xkdJ
HMLCPHOH_00414 2.5e-256 xkdK S Phage tail sheath C-terminal domain
HMLCPHOH_00415 6.1e-76 xkdM S Phage tail tube protein
HMLCPHOH_00416 1.9e-77 S Phage XkdN-like tail assembly chaperone protein, TAC
HMLCPHOH_00417 0.0 xkdO L Transglycosylase SLT domain
HMLCPHOH_00418 3.7e-122 xkdP S Lysin motif
HMLCPHOH_00419 4.8e-182 yqbQ 3.2.1.96 G NLP P60 protein
HMLCPHOH_00420 2.1e-39 xkdR S Protein of unknown function (DUF2577)
HMLCPHOH_00421 9.6e-71 xkdS S Protein of unknown function (DUF2634)
HMLCPHOH_00422 6e-191 xkdT S Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
HMLCPHOH_00423 4e-104 xkdU S Uncharacterised protein conserved in bacteria (DUF2313)
HMLCPHOH_00424 6.7e-41
HMLCPHOH_00425 0.0
HMLCPHOH_00426 2.6e-55 xkdW S XkdW protein
HMLCPHOH_00427 1.7e-23 xkdX
HMLCPHOH_00428 1.2e-154 xepA
HMLCPHOH_00429 2.8e-39 xhlA S Haemolysin XhlA
HMLCPHOH_00430 9.3e-40 xhlB S SPP1 phage holin
HMLCPHOH_00431 1.2e-163 xlyA 3.5.1.28 M n-acetylmuramoyl-L-alanine amidase
HMLCPHOH_00432 6.7e-23 spoIISB S Stage II sporulation protein SB
HMLCPHOH_00433 1.8e-136 spoIISA S Toxin SpoIISA, type II toxin-antitoxin system
HMLCPHOH_00434 5.8e-175 pit P phosphate transporter
HMLCPHOH_00435 6.9e-110 ykaA P COG1392 Phosphate transport regulator (distant homolog of PhoU)
HMLCPHOH_00436 9.4e-242 steT E amino acid
HMLCPHOH_00437 7.2e-183 mhqA E COG0346 Lactoylglutathione lyase and related lyases
HMLCPHOH_00439 0.0 ykcB M COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HMLCPHOH_00440 1.3e-179 ykcC GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
HMLCPHOH_00442 8.5e-214 htrA 3.4.21.107 O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HMLCPHOH_00443 1e-137 proG 1.5.1.2 E Pyrroline-5-carboxylate reductase
HMLCPHOH_00444 7.9e-154 dppA E D-aminopeptidase
HMLCPHOH_00445 1.1e-159 dppB P COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMLCPHOH_00446 3.9e-176 dppC EP COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMLCPHOH_00447 3.4e-191 dppD P Belongs to the ABC transporter superfamily
HMLCPHOH_00448 0.0 dppE E ABC transporter substrate-binding protein
HMLCPHOH_00450 8.1e-179 ykfA 3.4.17.13 V proteins, homologs of microcin C7 resistance protein MccF
HMLCPHOH_00451 3.2e-203 ykfB 5.1.1.20 M Belongs to the mandelate racemase muconate lactonizing enzyme family
HMLCPHOH_00452 5.3e-172 ykfC 3.4.14.13 M COG0791 Cell wall-associated hydrolases (invasion-associated proteins)
HMLCPHOH_00453 7.7e-188 ykfD E Belongs to the ABC transporter superfamily
HMLCPHOH_00454 2.1e-204 pgl 3.1.1.31 G 6-phosphogluconolactonase
HMLCPHOH_00455 5.3e-161 ykgA E Amidinotransferase
HMLCPHOH_00456 1.5e-92 ykhA 3.1.2.20 I Acyl-CoA hydrolase
HMLCPHOH_00457 1e-226 hmp 1.14.12.17 C Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HMLCPHOH_00458 1e-07
HMLCPHOH_00459 5.4e-130 ykjA S Protein of unknown function (DUF421)
HMLCPHOH_00460 1e-98 ykkA S Protein of unknown function (DUF664)
HMLCPHOH_00461 1e-98 ykkB 2.3.1.128 J COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
HMLCPHOH_00462 3.5e-55 ykkC P Multidrug resistance protein
HMLCPHOH_00463 1.1e-50 ykkD P Multidrug resistance protein
HMLCPHOH_00464 3.9e-170 purU 2.7.7.72, 3.5.1.10 F Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)
HMLCPHOH_00465 1e-201 proB 2.7.2.11 E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HMLCPHOH_00466 2.5e-228 proA 1.2.1.41, 1.2.1.81 E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HMLCPHOH_00467 1.3e-70 ohrA O Organic hydroperoxide resistance protein
HMLCPHOH_00468 3.9e-75 ohrR K COG1846 Transcriptional regulators
HMLCPHOH_00469 8.4e-72 ohrB O Organic hydroperoxide resistance protein
HMLCPHOH_00471 2.8e-87 guaD 3.5.4.12, 3.5.4.3, 3.5.4.33 FJ COG0590 Cytosine adenosine deaminases
HMLCPHOH_00472 0.0 metE 2.1.1.14 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HMLCPHOH_00473 1.7e-176 isp O Belongs to the peptidase S8 family
HMLCPHOH_00474 6.3e-151 T COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
HMLCPHOH_00475 1.8e-136 ykoC P Cobalt transport protein
HMLCPHOH_00476 9.1e-311 P ABC transporter, ATP-binding protein
HMLCPHOH_00477 6.9e-99 ykoE S ABC-type cobalt transport system, permease component
HMLCPHOH_00478 7.9e-111 ykoF S YKOF-related Family
HMLCPHOH_00479 2.4e-124 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HMLCPHOH_00480 9.4e-245 ykoH 2.7.13.3 T Histidine kinase
HMLCPHOH_00481 1.1e-113 ykoI S Peptidase propeptide and YPEB domain
HMLCPHOH_00482 4.4e-86 ykoJ S Peptidase propeptide and YPEB domain
HMLCPHOH_00485 2.2e-222 mgtE P Acts as a magnesium transporter
HMLCPHOH_00486 1.4e-53 tnrA K transcriptional
HMLCPHOH_00487 5.9e-18
HMLCPHOH_00488 6.9e-26 ykoL
HMLCPHOH_00489 1.3e-81 mhqR K transcriptional
HMLCPHOH_00490 2.3e-220 ugtP 2.4.1.315 GT28 M COG0707 UDP-N-acetylglucosamine LPS N-acetylglucosamine transferase
HMLCPHOH_00491 3.7e-99 ykoP G polysaccharide deacetylase
HMLCPHOH_00492 7.1e-155 ykoQ S Calcineurin-like phosphoesterase superfamily domain
HMLCPHOH_00493 0.0 ykoS
HMLCPHOH_00494 2.5e-186 ykoT GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
HMLCPHOH_00495 0.0 ligD 6.5.1.1 L ATP-dependent DNA ligase
HMLCPHOH_00496 3.2e-161 ku L With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HMLCPHOH_00497 0.0 ydcR 2.7.7.65 T Diguanylate cyclase
HMLCPHOH_00498 1.4e-116 ykoX S membrane-associated protein
HMLCPHOH_00499 2.1e-177 ykoY P COG0861 Membrane protein TerC, possibly involved in tellurium resistance
HMLCPHOH_00500 9.5e-130 sigI K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HMLCPHOH_00501 8.2e-117 rsgI S Anti-sigma factor N-terminus
HMLCPHOH_00502 1.9e-26 sspD S small acid-soluble spore protein
HMLCPHOH_00503 1.5e-124 ykrK S Domain of unknown function (DUF1836)
HMLCPHOH_00504 7e-156 htpX O Belongs to the peptidase M48B family
HMLCPHOH_00505 1.7e-233 ktrB P COG0168 Trk-type K transport systems, membrane components
HMLCPHOH_00506 1.2e-10 ydfR S Protein of unknown function (DUF421)
HMLCPHOH_00507 4.5e-22 ykzE
HMLCPHOH_00508 6.5e-190 ykrP G COG3594 Fucose 4-O-acetylase and related acetyltransferases
HMLCPHOH_00509 0.0 kinE 2.7.13.3 T Histidine kinase
HMLCPHOH_00510 7e-89 ogt 2.1.1.63 L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HMLCPHOH_00512 3.3e-197 mtnA 5.3.1.23 E Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HMLCPHOH_00513 7.5e-230 mtnK 2.7.1.100 F Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HMLCPHOH_00514 3.5e-151 mtnU 3.5.1.3 S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
HMLCPHOH_00515 8e-232 mtnE 2.6.1.83 E Aminotransferase
HMLCPHOH_00516 4.1e-231 mtnW 5.3.2.5 G Catalyzes the enolization of 2,3-diketo-5- methylthiopentyl-1-phosphate (DK-MTP-1-P) into 2-hydroxy-3-keto-5- methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P)
HMLCPHOH_00517 7.5e-137 mtnX 3.1.3.87, 4.2.1.109 E Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HMLCPHOH_00518 7.2e-115 mtnB 3.1.3.87, 4.1.2.17, 4.2.1.109, 5.1.3.4 E Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P)
HMLCPHOH_00519 1.3e-96 mtnD 1.13.11.53, 1.13.11.54 S Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HMLCPHOH_00520 1.3e-51 XK27_09985 S Protein of unknown function (DUF1232)
HMLCPHOH_00521 6.4e-09 S Spo0E like sporulation regulatory protein
HMLCPHOH_00522 1.4e-64 eag
HMLCPHOH_00523 2.5e-275 kinD 2.7.13.3 T COG0642 Signal transduction histidine kinase
HMLCPHOH_00524 1.3e-75 ykvE K transcriptional
HMLCPHOH_00525 2.5e-125 motB N Flagellar motor protein
HMLCPHOH_00526 2.7e-138 motA N flagellar motor
HMLCPHOH_00527 0.0 clpE O Belongs to the ClpA ClpB family
HMLCPHOH_00528 8.7e-182 ykvI S membrane
HMLCPHOH_00529 7.3e-126 queC 6.3.4.20 F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HMLCPHOH_00530 2.8e-81 queD 4.1.2.50, 4.2.3.12 H synthase
HMLCPHOH_00531 1.3e-139 queE 1.97.1.4, 4.3.99.3 H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
HMLCPHOH_00532 2e-96 queF 1.7.1.13 S Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HMLCPHOH_00533 2e-61 ykvN K Transcriptional regulator
HMLCPHOH_00534 8.2e-134 IQ Enoyl-(Acyl carrier protein) reductase
HMLCPHOH_00535 4e-217 ykvP 3.5.1.28 M Glycosyl transferases group 1
HMLCPHOH_00536 1.2e-35 3.5.1.104 M LysM domain
HMLCPHOH_00537 8.5e-133 G Glycosyl hydrolases family 18
HMLCPHOH_00538 5.6e-46 ykvR S Protein of unknown function (DUF3219)
HMLCPHOH_00539 6e-25 ykvS S protein conserved in bacteria
HMLCPHOH_00540 2.8e-28
HMLCPHOH_00541 1.7e-103 ykvT 3.5.1.28 M Cell Wall Hydrolase
HMLCPHOH_00542 9.9e-239 ykvU S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
HMLCPHOH_00543 4.9e-90 stoA CO thiol-disulfide
HMLCPHOH_00544 0.0 cadA 3.6.3.3, 3.6.3.5 P COG2217 Cation transport ATPase
HMLCPHOH_00545 3.8e-09
HMLCPHOH_00546 8.7e-209 pepQ 3.4.13.9 E COG0006 Xaa-Pro aminopeptidase
HMLCPHOH_00548 9.8e-180 ykvZ 5.1.1.1 K Transcriptional regulator
HMLCPHOH_00550 4.5e-128 glcT K antiterminator
HMLCPHOH_00551 0.0 ptsG 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
HMLCPHOH_00552 2.1e-39 ptsH G phosphocarrier protein HPr
HMLCPHOH_00553 0.0 ptsI 2.7.3.9 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HMLCPHOH_00554 7.2e-39 splA S Transcriptional regulator
HMLCPHOH_00555 2.6e-202 splB 4.1.99.14 L Spore photoproduct lyase
HMLCPHOH_00556 1.2e-131 ykwB 2.3.1.1 K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HMLCPHOH_00557 2e-264 mcpC NT chemotaxis protein
HMLCPHOH_00558 5e-159 glxR 1.1.1.31, 1.1.1.60 I COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases
HMLCPHOH_00559 8e-124 ykwD J protein with SCP PR1 domains
HMLCPHOH_00560 0.0 mrdA 3.4.16.4 M Penicillin-binding Protein
HMLCPHOH_00561 0.0 pilS 2.7.13.3 T Histidine kinase
HMLCPHOH_00562 8e-224 patA 2.6.1.1 E Aminotransferase
HMLCPHOH_00563 2.2e-15
HMLCPHOH_00564 1.6e-168 cheV 2.7.13.3 T Chemotaxis protein CheV
HMLCPHOH_00565 1.7e-84 ykyB S YkyB-like protein
HMLCPHOH_00566 1.6e-238 ykuC EGP Major facilitator Superfamily
HMLCPHOH_00567 4.6e-88 ykuD S protein conserved in bacteria
HMLCPHOH_00568 9.4e-166 ykuE S Metallophosphoesterase
HMLCPHOH_00569 2.2e-142 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HMLCPHOH_00570 0.0 3.2.1.132 M Putative peptidoglycan binding domain
HMLCPHOH_00571 1.7e-93 M Peptidoglycan-binding domain 1 protein
HMLCPHOH_00573 5.2e-234 ykuI T Diguanylate phosphodiesterase
HMLCPHOH_00574 3.9e-37 ykuJ S protein conserved in bacteria
HMLCPHOH_00575 4.4e-94 ykuK S Ribonuclease H-like
HMLCPHOH_00576 3.9e-27 ykzF S Antirepressor AbbA
HMLCPHOH_00577 1.6e-76 ykuL S CBS domain
HMLCPHOH_00578 3.5e-168 ccpC K Transcriptional regulator
HMLCPHOH_00579 5.7e-88 fld C Flavodoxin domain
HMLCPHOH_00580 3.2e-177 ykuO
HMLCPHOH_00581 3.2e-80 fld C Flavodoxin
HMLCPHOH_00582 1.1e-74 dapD 2.3.1.117, 2.3.1.89 E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
HMLCPHOH_00583 5.8e-216 hipO 3.5.1.47 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
HMLCPHOH_00584 9e-37 ykuS S Belongs to the UPF0180 family
HMLCPHOH_00585 8.8e-142 ykuT M Mechanosensitive ion channel
HMLCPHOH_00586 3.9e-101 ykuU O Alkyl hydroperoxide reductase
HMLCPHOH_00587 4.4e-82 ykuV CO thiol-disulfide
HMLCPHOH_00588 5.8e-95 rok K Repressor of ComK
HMLCPHOH_00589 2.9e-147 yknT
HMLCPHOH_00590 3.9e-110 mobA 2.7.7.77 H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
HMLCPHOH_00591 5.3e-192 moeB 2.7.7.73, 2.7.7.80 H COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
HMLCPHOH_00592 8.1e-246 moeA 2.10.1.1 H molybdopterin
HMLCPHOH_00593 9.9e-94 mobB 2.10.1.1, 2.7.7.77 H molybdopterin-guanine dinucleotide biosynthesis protein
HMLCPHOH_00594 8.5e-84 moaE 2.8.1.12 H COG0314 Molybdopterin converting factor, large subunit
HMLCPHOH_00595 2.8e-32 moaD 2.8.1.12 H Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HMLCPHOH_00596 0.0 yknU V COG1132 ABC-type multidrug transport system, ATPase and permease components
HMLCPHOH_00597 0.0 yknV V COG1132 ABC-type multidrug transport system, ATPase and permease components
HMLCPHOH_00598 1e-117 yknW S Yip1 domain
HMLCPHOH_00599 3e-159 acrA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HMLCPHOH_00600 2.5e-124 macB V ABC transporter, ATP-binding protein
HMLCPHOH_00601 2.1e-211 yknZ V COG0577 ABC-type antimicrobial peptide transport system, permease component
HMLCPHOH_00602 3.1e-136 fruR K Transcriptional regulator
HMLCPHOH_00603 6.2e-168 fruK 2.7.1.11, 2.7.1.56 G Belongs to the carbohydrate kinase PfkB family
HMLCPHOH_00604 0.0 fruA 2.7.1.202 GT COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type)
HMLCPHOH_00605 4.8e-105 sipT 3.4.21.89 U Belongs to the peptidase S26 family
HMLCPHOH_00606 8.1e-39 ykoA
HMLCPHOH_00607 5.8e-310 ybiT S COG0488 ATPase components of ABC transporters with duplicated ATPase domains
HMLCPHOH_00608 1.5e-169 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HMLCPHOH_00609 2e-238 ampS E COG2309 Leucyl aminopeptidase (aminopeptidase T)
HMLCPHOH_00610 1.1e-12 S Uncharacterized protein YkpC
HMLCPHOH_00611 7.7e-183 mreB D Rod-share determining protein MreBH
HMLCPHOH_00612 1.5e-43 abrB K of stationary sporulation gene expression
HMLCPHOH_00613 2.7e-241 kinC 2.7.13.3 T COG0642 Signal transduction histidine kinase
HMLCPHOH_00614 1.6e-162 ykqA P Gamma-glutamyl cyclotransferase, AIG2-like
HMLCPHOH_00615 4e-116 ktrA P COG0569 K transport systems, NAD-binding component
HMLCPHOH_00616 0.0 ade 3.5.4.2 F Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HMLCPHOH_00617 0.0 rnjA S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HMLCPHOH_00618 8.2e-31 ykzG S Belongs to the UPF0356 family
HMLCPHOH_00619 1.4e-147 ykrA S hydrolases of the HAD superfamily
HMLCPHOH_00620 4e-101 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
HMLCPHOH_00622 2e-115 recN L Putative cell-wall binding lipoprotein
HMLCPHOH_00623 9.9e-192 pdhA 1.2.4.1, 1.2.4.4 C COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
HMLCPHOH_00624 2.9e-179 pdhB 1.2.4.1, 1.2.4.4 C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
HMLCPHOH_00625 9.9e-231 pdhC 2.3.1.12 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
HMLCPHOH_00626 2.4e-243 lpdA 1.8.1.4 C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
HMLCPHOH_00627 1.3e-63 slp CO COG0526, thiol-disulfide isomerase and thioredoxins
HMLCPHOH_00628 3.5e-277 speA 4.1.1.19 E Arginine
HMLCPHOH_00629 1.6e-42 yktA S Belongs to the UPF0223 family
HMLCPHOH_00630 7.1e-118 yktB S Belongs to the UPF0637 family
HMLCPHOH_00631 7.1e-26 ykzI
HMLCPHOH_00632 4.6e-151 suhB 3.1.3.25 G Inositol monophosphatase
HMLCPHOH_00633 6.9e-78 ykzC S Acetyltransferase (GNAT) family
HMLCPHOH_00634 6.5e-173 Q Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HMLCPHOH_00635 2.2e-293 mpl 3.4.24.28, 3.4.24.29 E Peptidase M4
HMLCPHOH_00636 0.0 ylaA
HMLCPHOH_00637 2.7e-42 ylaB
HMLCPHOH_00638 2.7e-91 ylaC K Belongs to the sigma-70 factor family. ECF subfamily
HMLCPHOH_00639 1.2e-11 sigC S Putative zinc-finger
HMLCPHOH_00640 1.8e-38 ylaE
HMLCPHOH_00641 8.2e-22 S Family of unknown function (DUF5325)
HMLCPHOH_00642 0.0 typA T GTP-binding protein TypA
HMLCPHOH_00643 4.2e-47 ylaH S YlaH-like protein
HMLCPHOH_00644 2.5e-32 ylaI S protein conserved in bacteria
HMLCPHOH_00645 1.1e-89 ylaJ S Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
HMLCPHOH_00646 8e-249 phoH T ATPase related to phosphate starvation-inducible protein PhoH
HMLCPHOH_00647 2.7e-85 ylaL S Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HMLCPHOH_00648 1.6e-171 glsA 3.5.1.2 E Belongs to the glutaminase family
HMLCPHOH_00649 8.7e-44 ylaN S Belongs to the UPF0358 family
HMLCPHOH_00650 4.5e-214 ftsW D Belongs to the SEDS family
HMLCPHOH_00651 0.0 pyc 6.4.1.1 C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HMLCPHOH_00652 2.6e-166 ctaA 2.5.1.141 O Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group
HMLCPHOH_00653 3.2e-164 ctaB 2.5.1.141 O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
HMLCPHOH_00654 6.2e-191 ctaC 1.9.3.1 C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)
HMLCPHOH_00655 0.0 ctaD 1.10.3.12, 1.9.3.1 C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HMLCPHOH_00656 3.3e-112 cyoC 1.10.3.12, 1.9.3.1 C COG1845 Heme copper-type cytochrome quinol oxidase, subunit 3
HMLCPHOH_00657 4.2e-53 ctaF 1.10.3.12, 1.9.3.1 C COG3125 Heme copper-type cytochrome quinol oxidase, subunit 4
HMLCPHOH_00658 3e-167 ctaG S cytochrome c oxidase
HMLCPHOH_00659 7e-62 ylbA S YugN-like family
HMLCPHOH_00660 2.6e-74 ylbB T COG0517 FOG CBS domain
HMLCPHOH_00661 3e-201 ylbC S protein with SCP PR1 domains
HMLCPHOH_00662 4.1e-63 ylbD S Putative coat protein
HMLCPHOH_00663 6.7e-37 ylbE S YlbE-like protein
HMLCPHOH_00664 1.8e-75 ylbF S Belongs to the UPF0342 family
HMLCPHOH_00665 7.5e-39 ylbG S UPF0298 protein
HMLCPHOH_00666 1.9e-98 rsmD 2.1.1.171 L Methyltransferase
HMLCPHOH_00667 3.9e-84 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HMLCPHOH_00668 3.8e-221 ylbJ S Sporulation integral membrane protein YlbJ
HMLCPHOH_00669 7.5e-138 ylbK S esterase of the alpha-beta hydrolase superfamily
HMLCPHOH_00670 6.8e-187 ylbL T Belongs to the peptidase S16 family
HMLCPHOH_00671 2.8e-235 ylbM S Belongs to the UPF0348 family
HMLCPHOH_00673 1.3e-90 yceD S metal-binding, possibly nucleic acid-binding protein
HMLCPHOH_00674 1.2e-27 rpmF J Belongs to the bacterial ribosomal protein bL32 family
HMLCPHOH_00675 6.8e-75 ylbO S SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
HMLCPHOH_00676 4e-89 ylbP K n-acetyltransferase
HMLCPHOH_00677 7.3e-169 panE 1.1.1.169 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HMLCPHOH_00678 2.9e-309 bshC S Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HMLCPHOH_00679 2.9e-78 mraZ K Belongs to the MraZ family
HMLCPHOH_00680 6.6e-173 rsmH 2.1.1.199 J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
HMLCPHOH_00681 3.7e-44 ftsL D Essential cell division protein
HMLCPHOH_00682 0.0 ftsI 3.4.16.4 M Penicillin-binding Protein
HMLCPHOH_00683 0.0 ftsI 3.4.16.4 M stage V sporulation protein D
HMLCPHOH_00684 5.2e-281 murE 6.3.2.10, 6.3.2.13 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HMLCPHOH_00685 3.2e-170 mraY 2.7.8.13 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HMLCPHOH_00686 2.6e-255 murD 6.3.2.9 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HMLCPHOH_00687 5.7e-186 spoVE D Belongs to the SEDS family
HMLCPHOH_00688 2.3e-201 murG 2.4.1.227, 6.3.2.8 GT28 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HMLCPHOH_00689 5.3e-167 murB 1.3.1.98 M cell wall formation
HMLCPHOH_00690 2.6e-138 divIB D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
HMLCPHOH_00691 2.4e-103 ylxW S protein conserved in bacteria
HMLCPHOH_00692 1e-102 ylxX S protein conserved in bacteria
HMLCPHOH_00693 6.2e-58 sbp S small basic protein
HMLCPHOH_00694 7e-229 ftsA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
HMLCPHOH_00695 2e-203 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HMLCPHOH_00696 0.0 bpr O COG1404 Subtilisin-like serine proteases
HMLCPHOH_00697 4.4e-172 spoIIGA M aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR
HMLCPHOH_00698 1.4e-125 sigE K sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HMLCPHOH_00699 3.6e-140 sigG K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HMLCPHOH_00700 1.1e-147 modF 3.6.3.21, 3.6.3.34 P COG1119 ABC-type molybdenum transport system, ATPase component photorepair protein PhrA
HMLCPHOH_00701 1.3e-256 argE 3.5.1.16 E Acetylornithine deacetylase
HMLCPHOH_00702 2.4e-37 ylmC S sporulation protein
HMLCPHOH_00703 1.1e-158 yfiH S Belongs to the multicopper oxidase YfiH RL5 family
HMLCPHOH_00704 2.9e-125 ylmE S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HMLCPHOH_00705 1.4e-62 sepF D Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
HMLCPHOH_00706 1.3e-39 yggT S membrane
HMLCPHOH_00707 6.7e-139 ylmH 5.4.99.23, 5.4.99.24 S conserved protein, contains S4-like domain
HMLCPHOH_00708 2.6e-67 divIVA D Cell division initiation protein
HMLCPHOH_00709 0.0 ileS 6.1.1.5 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HMLCPHOH_00710 1.3e-63 dksA T COG1734 DnaK suppressor protein
HMLCPHOH_00711 1.8e-78 lspA 3.4.23.36 MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HMLCPHOH_00712 1.1e-164 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
HMLCPHOH_00713 2.7e-94 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HMLCPHOH_00714 9e-232 pyrP F Xanthine uracil
HMLCPHOH_00715 1.4e-167 pyrB 2.1.3.2 F Belongs to the ATCase OTCase family
HMLCPHOH_00716 1.7e-251 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
HMLCPHOH_00717 5e-212 carA 6.3.5.5 F Carbamoyl-phosphate synthetase glutamine chain
HMLCPHOH_00718 0.0 carB 6.3.5.5 F Belongs to the CarB family
HMLCPHOH_00719 4.8e-145 pyrK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )
HMLCPHOH_00720 2.9e-176 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
HMLCPHOH_00721 8e-126 pyrF 4.1.1.23 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
HMLCPHOH_00722 2.9e-116 pyrE 2.4.2.10, 4.1.1.23 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HMLCPHOH_00724 3.5e-142 cysH 1.8.4.10, 1.8.4.8, 2.7.1.25 EH Belongs to the PAPS reductase family. CysH subfamily
HMLCPHOH_00725 1.1e-179 cysP P phosphate transporter
HMLCPHOH_00726 1.3e-223 sat 2.7.7.4 P Belongs to the sulfate adenylyltransferase family
HMLCPHOH_00727 7.3e-109 cysC 2.7.1.25 P Catalyzes the synthesis of activated sulfate
HMLCPHOH_00728 2.2e-145 hemD 2.1.1.107, 4.2.1.75 H Belongs to the precorrin methyltransferase family
HMLCPHOH_00729 2e-146 cbiX 4.99.1.3, 4.99.1.4, 5.4.99.60, 5.4.99.61 S Sirohydrochlorin ferrochelatase
HMLCPHOH_00730 4.3e-83 cysG 1.3.1.76, 4.99.1.4 H Siroheme synthase
HMLCPHOH_00731 0.0 FbpA K RNA-binding protein homologous to eukaryotic snRNP
HMLCPHOH_00732 0.0 yloB 3.6.3.8 P COG0474 Cation transport ATPase
HMLCPHOH_00733 2.4e-156 yloC S stress-induced protein
HMLCPHOH_00734 1.5e-40 ylzA S Belongs to the UPF0296 family
HMLCPHOH_00735 3.1e-110 gmk 2.7.4.8 F Essential for recycling GMP and indirectly, cGMP
HMLCPHOH_00736 2.2e-28 rpoZ 2.7.7.6 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
HMLCPHOH_00737 8.8e-226 coaBC 4.1.1.36, 6.3.2.5 H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HMLCPHOH_00738 0.0 priA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HMLCPHOH_00739 6e-85 def 2.1.2.9, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
HMLCPHOH_00740 3.8e-176 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HMLCPHOH_00741 2.9e-254 sun 2.1.1.176 J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HMLCPHOH_00742 4.8e-207 rlmN 2.1.1.192 J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HMLCPHOH_00743 2.4e-141 stp 3.1.3.16 T phosphatase
HMLCPHOH_00744 0.0 prkC 2.7.11.1 KLT serine threonine protein kinase
HMLCPHOH_00745 8.6e-170 rsgA 3.1.3.100 S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
HMLCPHOH_00746 4.2e-118 rpe 5.1.3.1 G Belongs to the ribulose-phosphate 3-epimerase family
HMLCPHOH_00747 3.1e-121 thiN 2.7.6.2 H thiamine pyrophosphokinase
HMLCPHOH_00748 4.2e-26 rpmB J Belongs to the bacterial ribosomal protein bL28 family
HMLCPHOH_00749 5.5e-59 asp S protein conserved in bacteria
HMLCPHOH_00750 2.7e-302 yloV S kinase related to dihydroxyacetone kinase
HMLCPHOH_00751 1.9e-118 sdaAB 4.3.1.17 E L-serine dehydratase
HMLCPHOH_00752 9.3e-156 sdaAA 4.3.1.17 E L-serine dehydratase
HMLCPHOH_00753 0.0 recG 3.6.4.12 L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HMLCPHOH_00754 4e-80 fapR 5.3.1.23 K Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism
HMLCPHOH_00755 4.3e-178 plsX 2.3.1.15 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
HMLCPHOH_00756 9.1e-170 fabD 2.3.1.39 I malonyl CoA-acyl carrier protein transacylase
HMLCPHOH_00757 6.1e-129 IQ reductase
HMLCPHOH_00758 2.8e-32 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
HMLCPHOH_00759 1.2e-135 rnc 3.1.26.3 J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
HMLCPHOH_00760 0.0 smc D Required for chromosome condensation and partitioning
HMLCPHOH_00761 8.8e-176 ftsY U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HMLCPHOH_00762 2.9e-87
HMLCPHOH_00763 1.6e-49 ylxM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HMLCPHOH_00764 6e-236 ffh 3.6.5.4 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HMLCPHOH_00765 1.1e-43 rpsP J Belongs to the bacterial ribosomal protein bS16 family
HMLCPHOH_00766 1.2e-36 ylqC S Belongs to the UPF0109 family
HMLCPHOH_00767 1.3e-61 ylqD S YlqD protein
HMLCPHOH_00768 5.3e-95 rimM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HMLCPHOH_00769 9.2e-138 trmD 2.1.1.228, 4.6.1.12 J Belongs to the RNA methyltransferase TrmD family
HMLCPHOH_00770 1.4e-56 rplS J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
HMLCPHOH_00771 4.2e-158 ylqF S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HMLCPHOH_00772 4.1e-136 rnhB 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HMLCPHOH_00773 8.5e-291 ylqG
HMLCPHOH_00774 3e-44 ylqH S homolog of the cytoplasmic domain of flagellar protein FhlB
HMLCPHOH_00775 3.4e-211 sucC 6.2.1.5 C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
HMLCPHOH_00776 1.1e-167 sucD 6.2.1.5 C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HMLCPHOH_00777 1.7e-170 dprA LU Rossmann fold nucleotide-binding protein involved in DNA uptake
HMLCPHOH_00778 0.0 topA 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HMLCPHOH_00779 7.4e-247 trmFO 2.1.1.74 J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HMLCPHOH_00780 2.5e-169 xerC L tyrosine recombinase XerC
HMLCPHOH_00781 4.4e-92 hslV 3.4.25.2 O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HMLCPHOH_00782 1.5e-250 hslU O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HMLCPHOH_00783 9.2e-136 codY K DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HMLCPHOH_00784 2.3e-63 flgB N Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body
HMLCPHOH_00785 6.9e-75 flgC N Belongs to the flagella basal body rod proteins family
HMLCPHOH_00786 1.9e-31 fliE N Flagellar hook-basal body
HMLCPHOH_00787 2.4e-255 fliF N The M ring may be actively involved in energy transduction
HMLCPHOH_00788 2e-178 fliG N One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation
HMLCPHOH_00789 2.5e-106 fliH NU COG1317 Flagellar biosynthesis type III secretory pathway protein
HMLCPHOH_00790 2.5e-242 fliI 3.6.3.14 NU COG1157 Flagellar biosynthesis type III secretory pathway ATPase
HMLCPHOH_00791 1.5e-69 fliJ N Flagellar biosynthesis chaperone
HMLCPHOH_00792 7.7e-37 ylxF S MgtE intracellular N domain
HMLCPHOH_00793 1.2e-221 fliK N Flagellar hook-length control protein
HMLCPHOH_00794 1.7e-72 flgD N Flagellar basal body rod modification protein
HMLCPHOH_00795 8.2e-140 flgG N Flagellar basal body rod
HMLCPHOH_00796 4.6e-49 fliL N Controls the rotational direction of flagella during chemotaxis
HMLCPHOH_00797 1.9e-181 fliM N One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation
HMLCPHOH_00798 4.5e-184 fliN N FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HMLCPHOH_00799 1.6e-58 cheB 3.1.1.61, 3.5.1.44 T response regulator
HMLCPHOH_00800 9.3e-97 fliZ N Flagellar biosynthesis protein, FliO
HMLCPHOH_00801 1.6e-109 fliP N Plays a role in the flagellum-specific transport system
HMLCPHOH_00802 2.2e-36 fliQ N Role in flagellar biosynthesis
HMLCPHOH_00803 3.6e-132 fliR N Flagellar biosynthetic protein FliR
HMLCPHOH_00804 1.4e-190 flhB N Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HMLCPHOH_00805 0.0 flhA N Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HMLCPHOH_00806 5.2e-201 flhF N Flagellar biosynthesis regulator FlhF
HMLCPHOH_00807 7.5e-158 flhG D Belongs to the ParA family
HMLCPHOH_00808 5.8e-197 cheB 3.1.1.61, 3.5.1.44 NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR
HMLCPHOH_00809 0.0 cheA 2.7.13.3 NT COG0643 Chemotaxis protein histidine kinase and related kinases
HMLCPHOH_00810 2.8e-79 cheW NT COG0835 Chemotaxis signal transduction protein
HMLCPHOH_00811 1.3e-111 cheC NT COG1776 Chemotaxis protein CheC, inhibitor of MCP methylation
HMLCPHOH_00812 1.1e-86 cheD 3.5.1.44 NT Deamidates glutamine residues to glutamate on methyl- accepting chemotaxis receptors (MCPs). CheD-mediated MCP deamidation is required for productive communication of the conformational signals of the chemoreceptors to the CheA kinase
HMLCPHOH_00813 5.6e-138 sigD K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HMLCPHOH_00814 4.3e-78 ylxL
HMLCPHOH_00815 1e-131 rpsB J Belongs to the universal ribosomal protein uS2 family
HMLCPHOH_00816 6.3e-157 tsf J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HMLCPHOH_00817 2.7e-126 pyrH 2.7.4.22 F Catalyzes the reversible phosphorylation of UMP to UDP
HMLCPHOH_00818 6.4e-91 frr J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
HMLCPHOH_00819 8.3e-145 uppS 2.5.1.31 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HMLCPHOH_00820 1.2e-138 cdsA 2.7.7.41 S Belongs to the CDS family
HMLCPHOH_00821 4.6e-216 dxr 1.1.1.267 I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
HMLCPHOH_00822 7.7e-233 rasP M zinc metalloprotease
HMLCPHOH_00823 0.0 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
HMLCPHOH_00824 0.0 polC 2.7.7.7 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HMLCPHOH_00825 3.3e-80 rimP S Required for maturation of 30S ribosomal subunits
HMLCPHOH_00826 1.1e-203 nusA K Participates in both transcription termination and antitermination
HMLCPHOH_00827 3.4e-32 ylxR K nucleic-acid-binding protein implicated in transcription termination
HMLCPHOH_00828 3.1e-47 ylxQ J ribosomal protein
HMLCPHOH_00829 0.0 infB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HMLCPHOH_00830 3e-44 ylxP S protein conserved in bacteria
HMLCPHOH_00831 5e-57 rbfA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HMLCPHOH_00832 1.3e-173 truB 5.4.99.25 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HMLCPHOH_00833 6.1e-182 ribF 2.7.1.26, 2.7.7.2 H Belongs to the ribF family
HMLCPHOH_00834 6e-42 rpsO J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HMLCPHOH_00835 0.0 pnp 2.7.7.8 J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
HMLCPHOH_00836 4.2e-183 ylxY 3.5.1.104 G Sporulation protein, polysaccharide deacetylase
HMLCPHOH_00837 4.4e-233 pepR S Belongs to the peptidase M16 family
HMLCPHOH_00838 2.6e-42 ymxH S YlmC YmxH family
HMLCPHOH_00839 2.9e-162 spoVFA 1.1.1.29, 1.1.1.399, 1.1.1.95 CH Dipicolinate synthase subunit A
HMLCPHOH_00840 4.3e-109 spoVFB H Together with DpaA, catalyzes the conversion of dihydrodipicolinate to dipicolinate (DPA)
HMLCPHOH_00841 1.4e-192 asd 1.2.1.11 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HMLCPHOH_00842 5.9e-222 dapG 1.1.1.3, 2.7.2.4 E Belongs to the aspartokinase family
HMLCPHOH_00843 1.4e-156 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HMLCPHOH_00844 1.9e-308 rnjB S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HMLCPHOH_00845 5.3e-133 tepA 3.4.21.92 OU COG0740 Protease subunit of ATP-dependent Clp proteases
HMLCPHOH_00846 4.4e-32 S YlzJ-like protein
HMLCPHOH_00847 0.0 ftsK D Belongs to the FtsK SpoIIIE SftA family
HMLCPHOH_00848 1.4e-133 ymfC K Transcriptional regulator
HMLCPHOH_00849 1.5e-206 ymfD EGP Major facilitator Superfamily
HMLCPHOH_00850 2.9e-235 ymfF S Peptidase M16
HMLCPHOH_00851 1.4e-242 ymfH S zinc protease
HMLCPHOH_00852 9.2e-130 ymfI 1.1.1.100, 1.3.1.28 S Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
HMLCPHOH_00853 4.8e-41 ymfJ S Protein of unknown function (DUF3243)
HMLCPHOH_00854 2.7e-143 ymfK S Protein of unknown function (DUF3388)
HMLCPHOH_00855 1.9e-124 ymfM S protein conserved in bacteria
HMLCPHOH_00856 2.5e-101 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HMLCPHOH_00857 1.9e-236 cinA 3.5.1.42 S Belongs to the CinA family
HMLCPHOH_00858 8.1e-188 recA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HMLCPHOH_00859 1e-215 pbpX V Beta-lactamase
HMLCPHOH_00860 2.1e-224 rny S Endoribonuclease that initiates mRNA decay
HMLCPHOH_00861 1.9e-152 ymdB S protein conserved in bacteria
HMLCPHOH_00862 1.2e-36 spoVS S Stage V sporulation protein S
HMLCPHOH_00863 2.7e-199 tdh 1.1.1.103 C Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate
HMLCPHOH_00864 1.9e-217 kbl 2.3.1.29, 2.3.1.47 H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide
HMLCPHOH_00865 2.7e-296 miaB 2.8.4.3 J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HMLCPHOH_00866 9.2e-69 ymcA 3.6.3.21 S Belongs to the UPF0342 family
HMLCPHOH_00867 2.2e-88 cotE S Spore coat protein
HMLCPHOH_00868 0.0 mutS L that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HMLCPHOH_00869 0.0 mutL L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HMLCPHOH_00870 2.3e-70 S Regulatory protein YrvL
HMLCPHOH_00872 1.2e-97 ymcC S Membrane
HMLCPHOH_00873 4.4e-109 pksA K Transcriptional regulator
HMLCPHOH_00874 2.5e-129 pksB 3.1.2.6 S Polyketide biosynthesis
HMLCPHOH_00875 2.6e-163 fabD 2.3.1.39 I malonyl CoA-acyl carrier protein transacylase
HMLCPHOH_00876 2.4e-186 pksD Q Acyl transferase domain
HMLCPHOH_00877 0.0 fabD 1.13.12.16, 2.3.1.39 I malonyl CoA-acyl carrier protein transacylase
HMLCPHOH_00878 1.4e-37 acpK IQ Phosphopantetheine attachment site
HMLCPHOH_00879 2.7e-238 pksF 2.3.1.179, 2.3.1.41 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
HMLCPHOH_00880 1.3e-245 pksG 2.3.3.10 I synthase
HMLCPHOH_00881 2.6e-143 pksH 4.2.1.18 I enoyl-CoA hydratase
HMLCPHOH_00882 2.7e-137 pksI I Belongs to the enoyl-CoA hydratase isomerase family
HMLCPHOH_00883 0.0 rhiB IQ polyketide synthase
HMLCPHOH_00884 0.0 pfaA Q Polyketide synthase of type I
HMLCPHOH_00885 0.0 pfaA 4.1.1.35 GT4 IQ polyketide synthase
HMLCPHOH_00886 0.0 dhbF IQ polyketide synthase
HMLCPHOH_00887 0.0 pks13 HQ Beta-ketoacyl synthase
HMLCPHOH_00888 2.5e-233 cypA C Cytochrome P450
HMLCPHOH_00889 1.2e-61 ymzB
HMLCPHOH_00890 6.6e-164 ymaE S Metallo-beta-lactamase superfamily
HMLCPHOH_00891 4.6e-252 aprX O Belongs to the peptidase S8 family
HMLCPHOH_00892 2.1e-126 ymaC S Replication protein
HMLCPHOH_00893 5.4e-80 ymaD O redox protein, regulator of disulfide bond formation
HMLCPHOH_00894 4.7e-55 ebrB P COG2076 Membrane transporters of cations and cationic drugs
HMLCPHOH_00895 4.9e-51 ebrA P Small Multidrug Resistance protein
HMLCPHOH_00897 2.1e-46 ymaF S YmaF family
HMLCPHOH_00898 9.3e-175 miaA 2.5.1.75 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HMLCPHOH_00899 1.9e-33 hfq J RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs
HMLCPHOH_00900 6.3e-23
HMLCPHOH_00901 4.5e-22 ymzA
HMLCPHOH_00902 1.9e-49 nrdI 1.17.4.1 F Probably involved in ribonucleotide reductase function
HMLCPHOH_00903 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HMLCPHOH_00904 4.5e-188 nrdF 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HMLCPHOH_00905 2e-109 ymaB
HMLCPHOH_00906 8e-116 cwlC 3.5.1.28 M n-acetylmuramoyl-L-alanine amidase
HMLCPHOH_00907 1.7e-176 spoVK O stage V sporulation protein K
HMLCPHOH_00908 5.5e-231 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HMLCPHOH_00909 3.3e-244 ynbB 4.4.1.1 P COG4100 Cystathionine beta-lyase family protein involved in aluminum resistance
HMLCPHOH_00910 1.1e-68 glnR K transcriptional
HMLCPHOH_00911 7e-261 glnA 6.3.1.2 E glutamine synthetase
HMLCPHOH_00912 9.1e-132 L Belongs to the 'phage' integrase family
HMLCPHOH_00913 2.7e-42 E Zn peptidase
HMLCPHOH_00914 5.3e-25 K Helix-turn-helix XRE-family like proteins
HMLCPHOH_00916 3.6e-23
HMLCPHOH_00918 8.4e-82 S Phage regulatory protein Rha (Phage_pRha)
HMLCPHOH_00919 4.1e-12
HMLCPHOH_00922 9e-83 L DnaD domain protein
HMLCPHOH_00923 3.9e-25 S Loader and inhibitor of phage G40P
HMLCPHOH_00924 1.1e-170 dnaB 3.6.4.12 L replicative DNA helicase
HMLCPHOH_00925 3.2e-22
HMLCPHOH_00926 6.9e-19 S Phage-like element PBSX protein XtrA
HMLCPHOH_00928 3.5e-50 wecC 1.1.1.336 M ArpU family transcriptional regulator
HMLCPHOH_00932 9.8e-87 yrdC 3.5.1.19 Q Isochorismatase family
HMLCPHOH_00935 6.8e-79 L phage terminase small subunit
HMLCPHOH_00936 8.6e-304 S Terminase
HMLCPHOH_00937 2.2e-174 S Phage portal protein
HMLCPHOH_00938 3.4e-80 S peptidase activity
HMLCPHOH_00939 5.6e-154 gp36 S capsid protein
HMLCPHOH_00940 1.7e-20
HMLCPHOH_00941 1.7e-37 S Phage gp6-like head-tail connector protein
HMLCPHOH_00942 6.1e-38 S Phage head-tail joining protein
HMLCPHOH_00943 2.3e-50 S Bacteriophage HK97-gp10, putative tail-component
HMLCPHOH_00945 8.1e-79 S Phage tail tube protein
HMLCPHOH_00948 0.0 D phage tail tape measure protein
HMLCPHOH_00949 5.8e-112 S Phage tail protein
HMLCPHOH_00950 1.1e-221 NU Prophage endopeptidase tail
HMLCPHOH_00951 0.0 S Peptidase_G2, IMC autoproteolytic cleavage domain
HMLCPHOH_00952 2.5e-104 S Domain of unknown function (DUF2479)
HMLCPHOH_00955 2.1e-57 S Bacteriophage holin family
HMLCPHOH_00956 5.4e-125 xlyB 3.5.1.104, 3.5.1.28 M N-acetylmuramoyl-L-alanine amidase
HMLCPHOH_00957 2.7e-65 S Immunity protein 70
HMLCPHOH_00958 7.7e-177 A Pre-toxin TG
HMLCPHOH_00959 5.6e-110 S aspartate phosphatase
HMLCPHOH_00963 5e-10
HMLCPHOH_00964 2.5e-32
HMLCPHOH_00965 5.8e-39
HMLCPHOH_00966 6.8e-80 G regulation of fungal-type cell wall biogenesis
HMLCPHOH_00967 4.9e-145 ynaC
HMLCPHOH_00968 2e-99 ynaD J Acetyltransferase (GNAT) domain
HMLCPHOH_00969 1.9e-123 ynaE S Domain of unknown function (DUF3885)
HMLCPHOH_00970 6.4e-60 ynaF
HMLCPHOH_00973 1.1e-83 XK27_05370 5.3.1.24 E phosphoribosylanthranilate isomerase activity
HMLCPHOH_00974 2.7e-255 xynT G MFS/sugar transport protein
HMLCPHOH_00975 0.0 xynB 3.2.1.37 GH43 G Belongs to the glycosyl hydrolase 43 family
HMLCPHOH_00976 1e-215 xylR GK ROK family
HMLCPHOH_00977 4e-264 xylA 5.3.1.5 G Belongs to the xylose isomerase family
HMLCPHOH_00978 6e-293 xylB 2.7.1.12, 2.7.1.17, 2.7.1.5 G xylulose kinase
HMLCPHOH_00979 1.4e-113 yokF 3.1.31.1 L RNA catabolic process
HMLCPHOH_00980 3.5e-247 iolT EGP Major facilitator Superfamily
HMLCPHOH_00981 2.7e-219 alr 5.1.1.1 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HMLCPHOH_00982 6.3e-84 yncE S Protein of unknown function (DUF2691)
HMLCPHOH_00983 4.9e-78 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F Deoxyuridine 5'-triphosphate
HMLCPHOH_00984 5.2e-15
HMLCPHOH_00987 1.2e-165 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HMLCPHOH_00989 1.3e-134 S Domain of unknown function, YrpD
HMLCPHOH_00992 7.9e-25 tatA U protein secretion
HMLCPHOH_00993 1.8e-71
HMLCPHOH_00994 5.2e-80 yndB S Activator of Hsp90 ATPase homolog 1-like protein
HMLCPHOH_00997 5.7e-286 gerAA EG Spore germination protein
HMLCPHOH_00998 4.5e-197 gerAB U Spore germination
HMLCPHOH_00999 4.2e-220 gerLC S Spore germination protein
HMLCPHOH_01000 7.7e-154 yndG S DoxX-like family
HMLCPHOH_01001 2.6e-117 yndH S Domain of unknown function (DUF4166)
HMLCPHOH_01002 0.0 yndJ S YndJ-like protein
HMLCPHOH_01004 8.6e-139 yndL S Replication protein
HMLCPHOH_01005 5.8e-74 yndM S Protein of unknown function (DUF2512)
HMLCPHOH_01006 2e-79 fosB 2.5.1.18 H Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor
HMLCPHOH_01008 2.6e-109 lexA 3.4.21.88 K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HMLCPHOH_01009 3.4e-49 yneA D Inhibits cell division during the SOS response. Affects a later stage of the cell division protein assembly, after the assembly of the Z ring, by probably suppressing recruitment of FtsL and or DivIC to the division machinery
HMLCPHOH_01010 9.2e-113 yneB L resolvase
HMLCPHOH_01011 1.3e-32 ynzC S UPF0291 protein
HMLCPHOH_01012 0.0 tkt 2.2.1.1 G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HMLCPHOH_01013 2.2e-81 yneE S Sporulation inhibitor of replication protein sirA
HMLCPHOH_01014 1.8e-28 yneF S UPF0154 protein
HMLCPHOH_01015 7.5e-14 ynzD S Spo0E like sporulation regulatory protein
HMLCPHOH_01016 7.1e-127 ccdA O cytochrome c biogenesis protein
HMLCPHOH_01017 7.2e-59 cheB 3.1.1.61, 3.5.1.44 T cheY-homologous receiver domain
HMLCPHOH_01018 5.1e-76 yneJ O COG4846 Membrane protein involved in cytochrome C biogenesis
HMLCPHOH_01019 4.2e-74 yneK S Protein of unknown function (DUF2621)
HMLCPHOH_01020 4.1e-65 hspX O Spore coat protein
HMLCPHOH_01021 3.9e-19 sspP S Belongs to the SspP family
HMLCPHOH_01022 2.2e-14 sspO S Belongs to the SspO family
HMLCPHOH_01023 0.0 acnA 4.2.1.3 C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HMLCPHOH_01024 4.1e-92 yneN CO alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HMLCPHOH_01026 3.1e-08 sspN S Small acid-soluble spore protein N family
HMLCPHOH_01027 3.9e-35 tlp S Belongs to the Tlp family
HMLCPHOH_01028 1.2e-73 yneP S Thioesterase-like superfamily
HMLCPHOH_01029 1.3e-53 yneQ
HMLCPHOH_01030 4.1e-49 yneR S Belongs to the HesB IscA family
HMLCPHOH_01031 5e-94 plsY 2.3.1.15, 3.5.1.104 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
HMLCPHOH_01032 6.6e-69 yccU S CoA-binding protein
HMLCPHOH_01033 0.0 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HMLCPHOH_01034 0.0 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HMLCPHOH_01035 2.3e-12
HMLCPHOH_01036 1.3e-57 ynfC
HMLCPHOH_01037 8.2e-252 agcS E Sodium alanine symporter
HMLCPHOH_01038 2.4e-297 bglC5 3.2.1.4 GH5,GH9 G PFAM glycoside hydrolase family 5
HMLCPHOH_01040 3.7e-251 xynC 3.2.1.136 GH5 M Belongs to the glycosyl hydrolase 30 family
HMLCPHOH_01041 4.4e-299 xynD3 3.2.1.55 CBM6,GH43 G Belongs to the glycosyl hydrolase 43 family
HMLCPHOH_01042 2.4e-80 yngA S membrane
HMLCPHOH_01043 4.1e-164 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
HMLCPHOH_01044 5.5e-104 yngC S membrane-associated protein
HMLCPHOH_01045 1.9e-233 nrnB S phosphohydrolase (DHH superfamily)
HMLCPHOH_01046 6.3e-290 yngE 2.1.3.15, 6.4.1.3 I COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
HMLCPHOH_01047 2.2e-137 yngF 4.2.1.17 I Belongs to the enoyl-CoA hydratase isomerase family
HMLCPHOH_01048 8e-168 mvaB 4.1.3.4, 6.4.1.4 E Hydroxymethylglutaryl-CoA lyase
HMLCPHOH_01049 6e-32 pycB 2.3.1.12, 6.4.1.1 I Biotin carboxyl carrier protein
HMLCPHOH_01050 3e-251 yngH 6.3.4.14, 6.4.1.2, 6.4.1.3, 6.4.1.4 I Biotin carboxylase
HMLCPHOH_01051 0.0 yngI IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
HMLCPHOH_01052 4.4e-211 yngJ 1.3.8.1, 1.3.99.12 I acyl-CoA dehydrogenase
HMLCPHOH_01053 1.8e-31 S Family of unknown function (DUF5367)
HMLCPHOH_01055 1.3e-306 yngK T Glycosyl hydrolase-like 10
HMLCPHOH_01056 2.8e-64 yngL S Protein of unknown function (DUF1360)
HMLCPHOH_01057 0.0 6.3.2.14 Q amino acid activation for nonribosomal peptide biosynthetic process
HMLCPHOH_01058 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HMLCPHOH_01059 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HMLCPHOH_01060 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HMLCPHOH_01061 0.0 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HMLCPHOH_01062 4.3e-275 dacC 3.4.16.4 M D-alanyl-D-alanine carboxypeptidase
HMLCPHOH_01063 9e-189 yoxA 5.1.3.3 G Aldose 1-epimerase
HMLCPHOH_01064 2.3e-246 yoeA V MATE efflux family protein
HMLCPHOH_01065 1.1e-98 yoeB S IseA DL-endopeptidase inhibitor
HMLCPHOH_01067 2.2e-96 L Integrase
HMLCPHOH_01068 3e-34 yoeD G Helix-turn-helix domain
HMLCPHOH_01069 0.0 ggt 2.3.2.2, 3.4.19.13 E gamma-glutamyltransferase
HMLCPHOH_01070 2.5e-158 gltR1 K Transcriptional regulator
HMLCPHOH_01071 5e-187 yogA C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases
HMLCPHOH_01072 2.7e-293 gltD 1.4.1.13, 1.4.1.14 E COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases
HMLCPHOH_01073 0.0 gltB 1.4.1.13, 1.4.1.14, 1.4.7.1 E glutamate synthase
HMLCPHOH_01074 7.8e-155 gltC K Transcriptional regulator
HMLCPHOH_01075 4.1e-206 proB 2.7.2.11 E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HMLCPHOH_01076 2.5e-144 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HMLCPHOH_01077 1.9e-59 rtp K Plays a role in DNA replication and termination (fork arrest mechanism). Two dimers of rtp bind to the two inverted repeat regions (IRI and IRII) present in the termination site. The binding of each dimer is centered on an 8 bp direct repeat
HMLCPHOH_01078 2.2e-123 fabG 1.1.1.100 S Belongs to the short-chain dehydrogenases reductases (SDR) family
HMLCPHOH_01079 3e-42 yoxC S Bacterial protein of unknown function (DUF948)
HMLCPHOH_01080 3.1e-144 yoxB
HMLCPHOH_01081 7.5e-97 yoaA 2.3.1.128 J COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
HMLCPHOH_01082 6.2e-235 yoaB EGP Major facilitator Superfamily
HMLCPHOH_01083 1e-284 yoaC 2.7.1.12, 2.7.1.17, 2.7.1.189, 2.7.1.5 G FGGY family of carbohydrate kinases, C-terminal domain
HMLCPHOH_01084 1.7e-190 yoaD 1.1.1.399, 1.1.1.95 EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HMLCPHOH_01085 0.0 yoaE C belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HMLCPHOH_01086 1.9e-33 yoaF
HMLCPHOH_01087 2.2e-08 ywlA S Uncharacterised protein family (UPF0715)
HMLCPHOH_01088 7e-14
HMLCPHOH_01089 1.5e-38 S Protein of unknown function (DUF4025)
HMLCPHOH_01090 1.7e-187 mcpU NT methyl-accepting chemotaxis protein
HMLCPHOH_01091 8.7e-281 hpaB 1.14.14.9 Q COG2368 Aromatic ring hydroxylase
HMLCPHOH_01092 3.8e-133 yoaJ G Endoglucanase C-terminal domain subunit and related proteins
HMLCPHOH_01093 2.3e-111 yoaK S Membrane
HMLCPHOH_01094 2.5e-197 pelB 4.2.2.10, 4.2.2.2 G Amb_all
HMLCPHOH_01095 1.1e-132 yoqW S Belongs to the SOS response-associated peptidase family
HMLCPHOH_01097 3.8e-234 oxdC 4.1.1.2 G Oxalate decarboxylase
HMLCPHOH_01099 1.9e-146 yoaP 3.1.3.18 K YoaP-like
HMLCPHOH_01100 1.2e-66 yoaQ S Evidence 4 Homologs of previously reported genes of
HMLCPHOH_01101 4.1e-89
HMLCPHOH_01102 2.4e-172 yoaR V vancomycin resistance protein
HMLCPHOH_01103 4.3e-75 yoaS S Protein of unknown function (DUF2975)
HMLCPHOH_01104 4.2e-37 yozG K Transcriptional regulator
HMLCPHOH_01105 1.1e-149 yoaT S Protein of unknown function (DUF817)
HMLCPHOH_01106 8.6e-159 yoaU K LysR substrate binding domain
HMLCPHOH_01107 6e-160 yijE EG EamA-like transporter family
HMLCPHOH_01108 3.7e-78 yoaW
HMLCPHOH_01109 1.1e-118 yoaZ 1.11.1.6, 3.5.1.124 S DJ-1/PfpI family
HMLCPHOH_01110 2.3e-170 bla 3.5.2.6 V beta-lactamase
HMLCPHOH_01114 0.0 pps 2.7.9.2 GT phosphoenolpyruvate synthase
HMLCPHOH_01115 1.8e-121 xlnB 3.2.1.8 G Glycosyl hydrolases family 11
HMLCPHOH_01116 1.4e-37 S TM2 domain
HMLCPHOH_01117 5.7e-58 K Helix-turn-helix
HMLCPHOH_01119 1.6e-69 yoaQ S Evidence 4 Homologs of previously reported genes of
HMLCPHOH_01120 6.6e-127 yoqW S Belongs to the SOS response-associated peptidase family
HMLCPHOH_01121 1.8e-178 yobF
HMLCPHOH_01126 1.7e-207 S aspartate phosphatase
HMLCPHOH_01128 1.2e-123 dinB2 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HMLCPHOH_01129 1.4e-59 dinB2 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HMLCPHOH_01130 2.6e-38 S YolD-like protein
HMLCPHOH_01131 1.2e-49
HMLCPHOH_01132 0.0 K Psort location Cytoplasmic, score
HMLCPHOH_01133 2.7e-157 yobJ
HMLCPHOH_01134 3e-86 S SMI1-KNR4 cell-wall
HMLCPHOH_01135 0.0 L A nuclease of the HNH/ENDO VII superfamily with conserved LHH
HMLCPHOH_01136 7.9e-105 yokH G SMI1 / KNR4 family
HMLCPHOH_01137 9.5e-280 iaaM 1.4.3.4 E COG1231 Monoamine oxidase
HMLCPHOH_01138 0.0 yobO M Pectate lyase superfamily protein
HMLCPHOH_01139 9.9e-55 csaA 6.1.1.10, 6.1.1.20, 6.1.1.6 J tRNA-binding protein
HMLCPHOH_01140 1e-136 yobQ K helix_turn_helix, arabinose operon control protein
HMLCPHOH_01141 2.5e-143 yobR 2.3.1.1 J FR47-like protein
HMLCPHOH_01142 3e-99 yobS K Transcriptional regulator
HMLCPHOH_01143 4.2e-132 yobT S COG0491 Zn-dependent hydrolases, including glyoxylases
HMLCPHOH_01144 1.5e-88 yobU K Bacterial transcription activator, effector binding domain
HMLCPHOH_01145 9e-178 yobV K WYL domain
HMLCPHOH_01146 2.5e-95 yobW
HMLCPHOH_01147 1e-51 czrA K transcriptional
HMLCPHOH_01148 4.4e-118 pvaA M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)
HMLCPHOH_01149 1.5e-92 yozB S membrane
HMLCPHOH_01150 2.2e-145
HMLCPHOH_01151 1.9e-94 yocC
HMLCPHOH_01152 6.9e-189 yocD 3.4.17.13 V peptidase S66
HMLCPHOH_01153 4.1e-203 des 1.14.19.23, 1.14.19.45 I fatty acid desaturase
HMLCPHOH_01154 3.2e-198 desK 2.7.13.3 T Histidine kinase
HMLCPHOH_01155 1e-105 desR T COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HMLCPHOH_01156 7.1e-113 yocH CBM50 M COG1388 FOG LysM repeat
HMLCPHOH_01157 0.0 recQ 3.6.4.12 L DNA helicase
HMLCPHOH_01158 7.9e-114 azoR I Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HMLCPHOH_01159 3.3e-83 dksA T general stress protein
HMLCPHOH_01160 6.4e-54 yocL
HMLCPHOH_01161 6.6e-34
HMLCPHOH_01162 1.3e-87 yocM O Belongs to the small heat shock protein (HSP20) family
HMLCPHOH_01163 1.1e-40 yozN
HMLCPHOH_01164 1.9e-36 yocN
HMLCPHOH_01165 4.2e-56 yozO S Bacterial PH domain
HMLCPHOH_01166 2.7e-31 yozC
HMLCPHOH_01167 4e-289 dhaS 1.2.1.3, 1.2.1.39 C Belongs to the aldehyde dehydrogenase family
HMLCPHOH_01168 0.0 sqhC 4.2.1.137, 5.4.99.7 I COG1657 Squalene cyclase
HMLCPHOH_01169 5.4e-166 sodA 1.15.1.1 P Superoxide dismutase
HMLCPHOH_01170 3.4e-231 yocR S Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
HMLCPHOH_01171 5.1e-168 yocS S -transporter
HMLCPHOH_01172 1.8e-194 sucB 2.3.1.61 C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)
HMLCPHOH_01173 0.0 sucA 1.2.4.2, 4.1.1.71 C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)
HMLCPHOH_01174 0.0 yojO P Von Willebrand factor
HMLCPHOH_01175 1.1e-161 yojN S ATPase family associated with various cellular activities (AAA)
HMLCPHOH_01176 1e-110 sodC 1.15.1.1 P Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HMLCPHOH_01177 1.6e-198 sle1 3.5.1.28 CBM50 M COG1388 FOG LysM repeat
HMLCPHOH_01178 1.8e-231 yojK CG UDP-glucoronosyl and UDP-glucosyl transferase
HMLCPHOH_01179 1.2e-109 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HMLCPHOH_01181 4.2e-245 norM V Multidrug efflux pump
HMLCPHOH_01182 8.4e-151 T COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
HMLCPHOH_01183 2.1e-125 yojG S deacetylase
HMLCPHOH_01184 2.2e-60 yojF S Protein of unknown function (DUF1806)
HMLCPHOH_01185 1.5e-43
HMLCPHOH_01186 3.5e-163 rarD S -transporter
HMLCPHOH_01187 2.6e-61 yozR S COG0071 Molecular chaperone (small heat shock protein)
HMLCPHOH_01188 3.4e-09
HMLCPHOH_01189 8.2e-209 gntP EG COG2610 H gluconate symporter and related permeases
HMLCPHOH_01190 3.8e-66 yodA S tautomerase
HMLCPHOH_01191 1.7e-57 yodB K transcriptional
HMLCPHOH_01192 4.8e-108 yodC C nitroreductase
HMLCPHOH_01193 3.8e-113 mhqD S Carboxylesterase
HMLCPHOH_01194 5.8e-174 yodE E COG0346 Lactoylglutathione lyase and related lyases
HMLCPHOH_01195 6.2e-28 S Protein of unknown function (DUF3311)
HMLCPHOH_01196 4.2e-270 yodF E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HMLCPHOH_01197 1.9e-253 ctpA 3.4.21.102 M Belongs to the peptidase S41A family
HMLCPHOH_01198 1.7e-128 yodH Q Methyltransferase
HMLCPHOH_01199 5.2e-24 yodI
HMLCPHOH_01200 2.5e-139 vanY 3.4.17.14 M D-alanyl-D-alanine carboxypeptidase
HMLCPHOH_01201 3.2e-127 deoD 2.4.2.1, 2.4.2.28 F Purine nucleoside phosphorylase
HMLCPHOH_01202 5.3e-09
HMLCPHOH_01203 3.6e-54 yodL S YodL-like
HMLCPHOH_01204 5.4e-107 yodM 3.6.1.27 I Acid phosphatase homologues
HMLCPHOH_01205 2.8e-24 yozD S YozD-like protein
HMLCPHOH_01207 1.4e-124 yodN
HMLCPHOH_01208 1.4e-36 yozE S Belongs to the UPF0346 family
HMLCPHOH_01209 2.9e-47 yokU S YokU-like protein, putative antitoxin
HMLCPHOH_01210 1.4e-278 kamA 5.4.3.2 E lysine 2,3-aminomutase
HMLCPHOH_01211 2.5e-155 yodP 2.3.1.264 K Acetyltransferase (GNAT) family
HMLCPHOH_01212 1.4e-258 yodQ 3.5.1.16 E Acetylornithine deacetylase
HMLCPHOH_01213 1.6e-117 scoB 2.8.3.5, 2.8.3.8, 2.8.3.9 I COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit
HMLCPHOH_01214 8.1e-10 yodS 2.8.3.8, 2.8.3.9 I COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HMLCPHOH_01215 1.6e-249 yodT H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HMLCPHOH_01218 2.9e-145 yiiD K acetyltransferase
HMLCPHOH_01219 1e-256 cgeD M maturation of the outermost layer of the spore
HMLCPHOH_01220 3.5e-38 cgeC
HMLCPHOH_01221 1.2e-65 cgeA
HMLCPHOH_01222 3.3e-188 cgeB S Spore maturation protein
HMLCPHOH_01223 3.6e-213 phy 3.1.3.8 I Myo-inositol-hexaphosphate 3-phosphohydrolase
HMLCPHOH_01224 5.6e-125 4.2.1.115 GM Polysaccharide biosynthesis protein
HMLCPHOH_01225 1.4e-80 msrB 1.8.4.11, 1.8.4.12 O peptide methionine sulfoxide reductase
HMLCPHOH_01226 7e-103 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HMLCPHOH_01227 1.6e-70 ypoP K transcriptional
HMLCPHOH_01228 2.6e-223 mepA V MATE efflux family protein
HMLCPHOH_01229 5.5e-29 ypmT S Uncharacterized ympT
HMLCPHOH_01230 5e-99 ypmS S protein conserved in bacteria
HMLCPHOH_01231 1.3e-137 ypmR E GDSL-like Lipase/Acylhydrolase
HMLCPHOH_01232 3.2e-109 ypmQ S protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems
HMLCPHOH_01233 2e-39 ypmP S Protein of unknown function (DUF2535)
HMLCPHOH_01234 4.4e-244 ilvA 4.3.1.19 E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HMLCPHOH_01235 1.6e-185 pspF K Transcriptional regulator
HMLCPHOH_01236 4.2e-110 hlyIII S protein, Hemolysin III
HMLCPHOH_01237 7.4e-112 ypkP 2.3.1.51 I Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family
HMLCPHOH_01238 7.9e-96 folA 1.1.1.262, 1.5.1.3 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HMLCPHOH_01239 4.3e-157 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HMLCPHOH_01240 3.3e-92 pgpA 3.1.3.27 I COG1267 Phosphatidylglycerophosphatase A and related proteins
HMLCPHOH_01241 7.8e-114 ypjP S YpjP-like protein
HMLCPHOH_01242 1.3e-145 ypiP 2.1.1.242 AJ Putative SAM-dependent methyltransferase
HMLCPHOH_01243 1.7e-75 yphP S Belongs to the UPF0403 family
HMLCPHOH_01244 0.0 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
HMLCPHOH_01245 1.8e-156 ypgR C COG0694 Thioredoxin-like proteins and domains
HMLCPHOH_01246 3.1e-110 ypgQ S phosphohydrolase
HMLCPHOH_01247 2.3e-89 btuE 1.11.1.9 O Belongs to the glutathione peroxidase family
HMLCPHOH_01248 7.3e-177 metAA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HMLCPHOH_01249 2e-216 ugtP 2.4.1.315 GT28 M Processive glucosyltransferase involved in the biosynthesis of both the bilayer- and non-bilayer-forming membrane glucolipids. Is able to successively transfer up to three glucosyl residues to diacylglycerol (DAG), thereby catalyzing the formation of beta-monoglucosyl-DAG (3-O-(beta-D-glucopyranosyl)-1,2-diacyl- sn-glycerol), beta-diglucosyl-DAG (3-O-(beta-D-glucopyranosyl- beta-(1- 6)-D-glucopyranosyl)-1,2-diacyl-sn-glycerol) and beta- triglucosyl-DAG (3-O-(beta-D-glucopyranosyl-beta-(1- 6)-D- glucopyranosyl-beta-(1- 6)-D-glucopyranosyl)-1,2-diacyl-sn- glycerol). Beta-diglucosyl-DAG is the predominant glycolipid found in Bacillales and is also used as a membrane anchor for lipoteichoic acid (LTA)
HMLCPHOH_01250 7.9e-31 cspD K Cold-shock protein
HMLCPHOH_01251 3.8e-16 degR
HMLCPHOH_01252 8.1e-31 S Protein of unknown function (DUF2564)
HMLCPHOH_01253 3e-29 ypeQ S Zinc-finger
HMLCPHOH_01254 8.9e-127 ypeP 3.1.26.4 L COG0328 Ribonuclease HI
HMLCPHOH_01255 5.4e-107 ypdP S Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HMLCPHOH_01256 8.5e-69 rnhA 3.1.26.4 L Ribonuclease
HMLCPHOH_01258 1.5e-166 polA 2.7.7.7 L 5'3' exonuclease
HMLCPHOH_01259 2e-07
HMLCPHOH_01260 1e-38 ypbS S Protein of unknown function (DUF2533)
HMLCPHOH_01261 0.0 ypbR S Dynamin family
HMLCPHOH_01262 5.1e-87 ypbQ S protein conserved in bacteria
HMLCPHOH_01263 4.4e-208 bcsA Q Naringenin-chalcone synthase
HMLCPHOH_01264 1.6e-228 pbuX F xanthine
HMLCPHOH_01265 8.8e-99 xpt 2.4.2.22, 2.4.2.7 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
HMLCPHOH_01266 4.2e-294 ypwA 3.4.17.19 E Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HMLCPHOH_01267 5e-171 kdgT P The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system
HMLCPHOH_01268 7e-104 eda 2.7.1.45, 4.1.2.14, 4.1.3.42 G 2-dehydro-3-deoxy-phosphogluconate aldolase
HMLCPHOH_01269 2.9e-187 kdgK 2.7.1.45 G COG0524 Sugar kinases, ribokinase family
HMLCPHOH_01270 3.9e-187 ptxS K transcriptional
HMLCPHOH_01271 1.7e-159 kduI 5.3.1.17 G Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HMLCPHOH_01272 7.1e-133 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HMLCPHOH_01273 0.0 ypvA 3.6.4.12 KL COG1199 Rad3-related DNA helicases
HMLCPHOH_01275 5.4e-225 rlmL 2.1.1.173, 2.1.1.264 L Belongs to the methyltransferase superfamily
HMLCPHOH_01276 2.8e-45 gpsB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
HMLCPHOH_01277 3.3e-92 ypsA S Belongs to the UPF0398 family
HMLCPHOH_01278 1.3e-237 yprB L RNase_H superfamily
HMLCPHOH_01279 0.0 yprA L COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster
HMLCPHOH_01280 1.9e-81 ypqE 2.7.1.199 G COG2190 Phosphotransferase system IIA components
HMLCPHOH_01281 8.6e-72 hspX O Belongs to the small heat shock protein (HSP20) family
HMLCPHOH_01282 1.2e-48 yppG S YppG-like protein
HMLCPHOH_01284 2e-11 yppE S Bacterial domain of unknown function (DUF1798)
HMLCPHOH_01287 2.6e-188 yppC S Protein of unknown function (DUF2515)
HMLCPHOH_01288 1.2e-114 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
HMLCPHOH_01289 0.0 ponA 2.4.1.129, 2.7.7.7, 3.4.16.4 GT51 M penicillin-binding protein
HMLCPHOH_01290 4.7e-93 ypoC
HMLCPHOH_01291 2.2e-122 nth 4.2.99.18 L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HMLCPHOH_01292 5.7e-129 dnaD L DNA replication protein DnaD
HMLCPHOH_01293 5.8e-252 asnS 6.1.1.22 J asparaginyl-tRNA
HMLCPHOH_01294 1.5e-222 aspB 2.6.1.1, 2.6.1.14 E Aminotransferase
HMLCPHOH_01295 3.4e-80 ypmB S protein conserved in bacteria
HMLCPHOH_01296 6.7e-23 ypmA S Protein of unknown function (DUF4264)
HMLCPHOH_01297 0.0 dinG 2.7.7.7, 3.6.4.12 L helicase involved in DNA repair and perhaps also replication
HMLCPHOH_01298 3.5e-64 panD 4.1.1.11 H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HMLCPHOH_01299 1.2e-157 panC 2.7.4.25, 6.3.2.1 H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HMLCPHOH_01300 1.4e-150 panB 2.1.2.11 H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
HMLCPHOH_01301 8.7e-184 birA 6.3.4.15 K Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
HMLCPHOH_01302 4.4e-222 cca 2.7.7.19, 2.7.7.72 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HMLCPHOH_01303 3.7e-210 bshA GT4 M N-acetyl-alpha-D-glucosaminyl L-malate synthase
HMLCPHOH_01304 6.9e-130 bshB1 S proteins, LmbE homologs
HMLCPHOH_01305 6.5e-72 mgsA 2.7.1.24, 4.2.3.3 G methylglyoxal synthase
HMLCPHOH_01306 1.8e-147 dapB 1.17.1.8 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
HMLCPHOH_01307 2.6e-55 ypjD 2.5.1.19 S Nucleotide pyrophosphohydrolase
HMLCPHOH_01308 8.1e-157 ypjC S Uncharacterized protein conserved in bacteria (DUF2179)
HMLCPHOH_01309 6.1e-143 ypjB S sporulation protein
HMLCPHOH_01310 2e-98 ypjA S membrane
HMLCPHOH_01311 1.5e-146 qcrC C Menaquinol-cytochrome c reductase cytochrome b c subunit
HMLCPHOH_01312 5.2e-127 petB C COG1290 Cytochrome b subunit of the bc complex
HMLCPHOH_01313 9.3e-97 qcrA C Menaquinol-cytochrome c reductase
HMLCPHOH_01314 8.5e-78 ypiF S Protein of unknown function (DUF2487)
HMLCPHOH_01315 2.8e-99 ypiB S Belongs to the UPF0302 family
HMLCPHOH_01316 4.1e-234 S COG0457 FOG TPR repeat
HMLCPHOH_01317 8.9e-237 aroA 1.3.1.12, 1.3.1.43, 2.5.1.19 E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
HMLCPHOH_01318 1.2e-208 tyrA 1.3.1.12, 1.3.1.43 E prephenate dehydrogenase
HMLCPHOH_01319 2.9e-204 hisC 2.6.1.9 E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HMLCPHOH_01320 5.5e-144 trpA 4.2.1.20 E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
HMLCPHOH_01321 4e-231 trpB 4.2.1.20, 5.3.1.24 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HMLCPHOH_01322 6.5e-119 trpF 4.1.1.48, 4.2.1.160, 4.2.1.20, 5.3.1.24 E Belongs to the TrpF family
HMLCPHOH_01323 4.7e-113 trpC 4.1.1.48, 5.3.1.24 E Belongs to the TrpC family
HMLCPHOH_01324 1.2e-180 trpD 2.4.2.18, 4.1.3.27 E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HMLCPHOH_01325 6.6e-295 trpE 4.1.3.27 EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HMLCPHOH_01326 1e-63 aroH 2.7.4.25, 5.4.99.5 E Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis
HMLCPHOH_01327 8.1e-207 aroB 2.7.1.71, 4.2.3.4 E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HMLCPHOH_01328 5.5e-217 aroC 4.2.3.5 E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HMLCPHOH_01329 2.9e-142 cheR 2.1.1.80 NT COG1352 Methylase of chemotaxis methyl-accepting proteins
HMLCPHOH_01330 9.1e-80 ndk 2.7.4.6 F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
HMLCPHOH_01331 4.5e-194 hepT 2.5.1.30, 2.5.1.83, 2.5.1.90 H Belongs to the FPP GGPP synthase family
HMLCPHOH_01332 8.6e-133 menG 2.1.1.163, 2.1.1.201 H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)
HMLCPHOH_01333 5.6e-138 hepS 2.5.1.30 H Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1
HMLCPHOH_01334 2.3e-34 mtrB K Required for transcription attenuation control in the Trp operon. This trans-acting factor seems to recognize a 10 bases nucleotide sequence in the Trp leader transcript causing transcription termination. Binds the leader RNA only in presence of L-tryptophan
HMLCPHOH_01335 7.1e-101 folE 3.5.4.16 H GTP cyclohydrolase
HMLCPHOH_01336 4.7e-42 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
HMLCPHOH_01337 3.7e-279 spoIVA S ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HMLCPHOH_01338 5.4e-138 yphF
HMLCPHOH_01339 1.6e-18 yphE S Protein of unknown function (DUF2768)
HMLCPHOH_01340 2.3e-190 gpsA 1.1.1.94 I Glycerol-3-phosphate dehydrogenase
HMLCPHOH_01341 3.9e-248 der 1.1.1.399, 1.1.1.95 S GTPase that plays an essential role in the late steps of ribosome biogenesis
HMLCPHOH_01342 1.6e-28 ypzH
HMLCPHOH_01343 2.5e-161 seaA S YIEGIA protein
HMLCPHOH_01344 1.3e-102 yphA
HMLCPHOH_01345 1e-07 S YpzI-like protein
HMLCPHOH_01346 4.1e-187 fni 1.1.1.88, 5.3.3.2 C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
HMLCPHOH_01347 4.3e-206 rpsA 1.17.7.4 J Ribosomal protein S1
HMLCPHOH_01348 1.9e-113 cmk 1.17.7.4, 2.5.1.19, 2.7.1.26, 2.7.4.25, 2.7.7.2, 6.3.2.1 F Belongs to the cytidylate kinase family. Type 1 subfamily
HMLCPHOH_01349 1.8e-23 S Family of unknown function (DUF5359)
HMLCPHOH_01350 9.2e-113 ypfA M Flagellar protein YcgR
HMLCPHOH_01351 6.5e-254 hemX 2.1.1.107, 4.2.1.75 H sporulation protein
HMLCPHOH_01352 4.7e-155 sleB 3.5.1.28 M Spore cortex-lytic enzyme
HMLCPHOH_01353 1e-119 prsW S Involved in the degradation of specific anti-sigma factors
HMLCPHOH_01354 1.6e-174 ypdA 1.18.1.2, 1.19.1.1, 1.8.1.9 O COG0492 Thioredoxin reductase
HMLCPHOH_01355 2.6e-244 gudB 1.4.1.2, 1.4.1.3 E Belongs to the Glu Leu Phe Val dehydrogenases family
HMLCPHOH_01356 2.4e-104 mecB NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC
HMLCPHOH_01357 1.8e-147 ypbG S Calcineurin-like phosphoesterase superfamily domain
HMLCPHOH_01358 2.8e-81 ypbF S Protein of unknown function (DUF2663)
HMLCPHOH_01359 4.6e-81 ypbE M Lysin motif
HMLCPHOH_01360 2.2e-100 ypbD S metal-dependent membrane protease
HMLCPHOH_01361 3.2e-286 recQ 3.6.4.12 L DNA helicase
HMLCPHOH_01362 3.8e-201 ypbB 5.1.3.1 S protein conserved in bacteria
HMLCPHOH_01363 4.7e-41 fer C Ferredoxin
HMLCPHOH_01364 5.8e-87 fmnP U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HMLCPHOH_01365 1.5e-294 serA 1.1.1.399, 1.1.1.95 E Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HMLCPHOH_01366 9e-136 aroD 1.1.1.25, 4.2.1.10 E Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
HMLCPHOH_01367 6.8e-201 rsiX
HMLCPHOH_01368 2.6e-103 sigX K Belongs to the sigma-70 factor family. ECF subfamily
HMLCPHOH_01369 0.0 resE 2.7.13.3 T Histidine kinase
HMLCPHOH_01370 2.3e-133 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HMLCPHOH_01371 3.9e-215 ccsA O 'COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component'
HMLCPHOH_01372 0.0 ccs1 O COG1333 ResB protein required for cytochrome c biosynthesis
HMLCPHOH_01373 1.3e-99 resA CO Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c
HMLCPHOH_01374 6.9e-133 rluB 5.4.99.19, 5.4.99.21, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
HMLCPHOH_01375 1.9e-87 spmB S Spore maturation protein
HMLCPHOH_01376 3.5e-103 spmA S Spore maturation protein
HMLCPHOH_01377 1.2e-213 dacB 3.4.16.4 M Belongs to the peptidase S11 family
HMLCPHOH_01378 4e-98 ypuI S Protein of unknown function (DUF3907)
HMLCPHOH_01379 1.9e-104 scpB D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HMLCPHOH_01380 4.5e-130 scpA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HMLCPHOH_01381 4.5e-94 ypuF S Domain of unknown function (DUF309)
HMLCPHOH_01382 4.5e-64 ribT K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HMLCPHOH_01383 3.9e-81 ribH 2.5.1.78 H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
HMLCPHOH_01384 9.8e-230 ribBA 3.5.4.25, 4.1.99.12 H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HMLCPHOH_01385 1.5e-115 ribE 2.5.1.9 H Riboflavin synthase
HMLCPHOH_01386 1.3e-204 ribD 1.1.1.193, 3.5.4.26 H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HMLCPHOH_01387 6e-55 ypuD
HMLCPHOH_01388 5.2e-101 sipT 3.4.21.89 U Belongs to the peptidase S26 family
HMLCPHOH_01389 2.3e-33 yhcC S nucleic-acid-binding protein containing a Zn-ribbon domain
HMLCPHOH_01390 1.5e-17 S SNARE associated Golgi protein
HMLCPHOH_01393 8e-81 ppiB 5.2.1.8 O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HMLCPHOH_01394 1.3e-149 ypuA S Secreted protein
HMLCPHOH_01395 5.2e-256 lysA 4.1.1.19, 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
HMLCPHOH_01396 1.4e-273 spoVAF EG Stage V sporulation protein AF
HMLCPHOH_01397 1.4e-110 spoVAEA S stage V sporulation protein
HMLCPHOH_01398 2.2e-57 spoVAEB S stage V sporulation protein
HMLCPHOH_01399 9e-192 spoVAD I Stage V sporulation protein AD
HMLCPHOH_01400 2.3e-78 spoVAC S stage V sporulation protein AC
HMLCPHOH_01401 1e-67 spoVAB S Stage V sporulation protein AB
HMLCPHOH_01402 7.4e-112 spoVAA S Stage V sporulation protein AA
HMLCPHOH_01403 2.4e-136 sigF K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HMLCPHOH_01404 1.8e-75 spoIIAB 2.7.11.1 F Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition
HMLCPHOH_01405 3.9e-57 spoIIAA T Belongs to the anti-sigma-factor antagonist family
HMLCPHOH_01406 2.8e-213 dacF 3.4.16.4 M Belongs to the peptidase S11 family
HMLCPHOH_01407 1.7e-148 punA 2.4.2.1 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HMLCPHOH_01408 1.2e-232 deoB 5.4.2.7 G Phosphotransfer between the C1 and C5 carbon atoms of pentose
HMLCPHOH_01409 2.6e-166 xerD L recombinase XerD
HMLCPHOH_01410 3.7e-37 S Protein of unknown function (DUF4227)
HMLCPHOH_01411 2.4e-80 fur P Belongs to the Fur family
HMLCPHOH_01412 2.3e-108 spoIIM S Required for complete septum migration and engulfment of the forespore compartment during sporulation. Required for stabilizing and recruiting of SpoIIP to the septal membrane
HMLCPHOH_01413 2e-32 yqkK
HMLCPHOH_01414 5.5e-242 mleA 1.1.1.38 C malic enzyme
HMLCPHOH_01415 3.1e-235 mleN C Na H antiporter
HMLCPHOH_01416 2.9e-268 aspA 4.2.1.2, 4.3.1.1 E Aspartate ammonia-lyase
HMLCPHOH_01417 3.6e-185 ansA 3.5.1.1 EJ L-asparaginase
HMLCPHOH_01418 4.5e-58 ansR K Transcriptional regulator
HMLCPHOH_01419 3e-223 yqxK 3.6.4.12 L DNA helicase
HMLCPHOH_01420 1.2e-92 nudF 3.6.1.13 L Belongs to the Nudix hydrolase family
HMLCPHOH_01422 4.4e-169 yqkF C oxidoreductases (related to aryl-alcohol dehydrogenases)
HMLCPHOH_01423 4e-14 yqkE S Protein of unknown function (DUF3886)
HMLCPHOH_01424 2.4e-175 yqkD S COG1073 Hydrolases of the alpha beta superfamily
HMLCPHOH_01425 9.4e-39 yqkC S Protein of unknown function (DUF2552)
HMLCPHOH_01426 2.8e-54 yqkB S Belongs to the HesB IscA family
HMLCPHOH_01427 4.7e-196 yqkA K GrpB protein
HMLCPHOH_01428 8e-60 yqjZ 2.3.1.128, 2.5.1.18 S enzyme involved in biosynthesis of extracellular polysaccharides
HMLCPHOH_01429 3.6e-87 yqjY K acetyltransferase
HMLCPHOH_01430 2.2e-49 S YolD-like protein
HMLCPHOH_01431 3.1e-239 polYB 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HMLCPHOH_01433 5.2e-226 yqjV G Major Facilitator Superfamily
HMLCPHOH_01435 7.2e-73 yqjT 3.1.26.4 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HMLCPHOH_01436 2.4e-178 coaA 2.7.1.33 F Pantothenic acid kinase
HMLCPHOH_01437 2.4e-264 dsdA 4.3.1.18 E Belongs to the serine threonine dehydratase family. DsdA subfamily
HMLCPHOH_01438 3.5e-143 yqjQ S Belongs to the short-chain dehydrogenases reductases (SDR) family
HMLCPHOH_01439 3.4e-180 yqjP S COG0491 Zn-dependent hydrolases, including glyoxylases
HMLCPHOH_01440 8.6e-148 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HMLCPHOH_01441 0.0 rocB E arginine degradation protein
HMLCPHOH_01442 1.4e-192 namA 1.6.99.1 C Catalyzes the reduction of the double bond of an array of alpha,beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes
HMLCPHOH_01443 9.6e-146 yqjL S hydrolases or acyltransferases (alpha beta hydrolase superfamily)
HMLCPHOH_01444 2.9e-173 rnz 3.1.26.11 S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
HMLCPHOH_01445 1.6e-290 zwf 1.1.1.363, 1.1.1.49 G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HMLCPHOH_01446 6.9e-267 gnd 1.1.1.343, 1.1.1.44 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HMLCPHOH_01447 7.3e-236 dinB 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HMLCPHOH_01448 4.5e-24 yqzJ
HMLCPHOH_01449 5.7e-144 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HMLCPHOH_01450 3.6e-142 yqjF S Uncharacterized conserved protein (COG2071)
HMLCPHOH_01451 1.6e-202 yqjE 3.4.11.4 E COG2195 Di- and tripeptidases
HMLCPHOH_01452 4.4e-291 mmdA 2.1.3.15, 6.4.1.3 I COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
HMLCPHOH_01453 2.2e-75 mce 4.4.1.5, 5.1.99.1, 5.4.99.2 E COG0346 Lactoylglutathione lyase and related lyases
HMLCPHOH_01455 1.4e-98 yqjB S protein conserved in bacteria
HMLCPHOH_01456 1.1e-175 yqjA S Putative aromatic acid exporter C-terminal domain
HMLCPHOH_01457 2e-129 artM 3.6.3.21 E COG1126 ABC-type polar amino acid transport system, ATPase component
HMLCPHOH_01458 6.2e-109 artQ E COG0765 ABC-type amino acid transport system, permease component
HMLCPHOH_01459 6.3e-137 artP ET Belongs to the bacterial solute-binding protein 3 family
HMLCPHOH_01460 9.3e-77 yqiW S Belongs to the UPF0403 family
HMLCPHOH_01461 8.8e-167 yegS 2.7.1.107 I COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
HMLCPHOH_01462 7.9e-208 norA EGP Major facilitator Superfamily
HMLCPHOH_01463 2.6e-152 bmrR K helix_turn_helix, mercury resistance
HMLCPHOH_01464 3.5e-233 bfmBB 2.3.1.168, 2.3.1.61 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
HMLCPHOH_01465 1.8e-184 bfmBAB 1.2.4.1, 1.2.4.4 C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
HMLCPHOH_01466 1.9e-186 bfmBAA 1.2.4.4 C COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
HMLCPHOH_01467 3.4e-269 lpdA 1.8.1.4 C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
HMLCPHOH_01468 1.2e-202 buk 2.7.2.7 C Belongs to the acetokinase family
HMLCPHOH_01469 2.2e-207 ldh 1.4.1.9 E Belongs to the Glu Leu Phe Val dehydrogenases family
HMLCPHOH_01470 7.1e-156 pta 2.3.1.19, 2.3.1.8 C phosphate butyryltransferase
HMLCPHOH_01471 0.0 bkdR 2.7.13.3 KT Transcriptional regulator
HMLCPHOH_01472 4e-34 yqzF S Protein of unknown function (DUF2627)
HMLCPHOH_01473 7.1e-164 prpB 4.1.3.30 G Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HMLCPHOH_01474 5.7e-277 prpD 4.2.1.79 S 2-methylcitrate dehydratase
HMLCPHOH_01475 8.1e-210 prpC 2.3.3.1, 2.3.3.5 C Belongs to the citrate synthase family
HMLCPHOH_01476 1.8e-212 mmgC I acyl-CoA dehydrogenase
HMLCPHOH_01477 4.7e-157 hbdA 1.1.1.157 I Dehydrogenase
HMLCPHOH_01478 1.2e-219 mmgA 2.3.1.9 I Belongs to the thiolase family
HMLCPHOH_01479 1.8e-133 yqiK 3.1.4.46 C glycerophosphoryl diester phosphodiesterase
HMLCPHOH_01480 5.4e-107 amiC 3.5.1.28 M Cell wall hydrolase autolysin
HMLCPHOH_01481 5.9e-27
HMLCPHOH_01482 1.3e-215 yqiG C COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family
HMLCPHOH_01484 3.2e-144 KT May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process
HMLCPHOH_01485 1.2e-238 rseP 3.4.21.116 M Stage IV sporulation protein B
HMLCPHOH_01486 0.0 recN L May be involved in recombinational repair of damaged DNA
HMLCPHOH_01487 1.7e-78 argR K Regulates arginine biosynthesis genes
HMLCPHOH_01488 6.6e-156 rrmJ 2.1.1.226, 2.1.1.227 J rRNA methylase
HMLCPHOH_01489 0.0 dxs 2.2.1.7 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HMLCPHOH_01490 7.7e-163 ispA 2.5.1.1, 2.5.1.10, 2.5.1.29, 2.5.1.90 H Belongs to the FPP GGPP synthase family
HMLCPHOH_01491 5.8e-39 xseB 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HMLCPHOH_01492 2.2e-246 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HMLCPHOH_01493 1e-156 folD 1.5.1.5, 3.5.4.9 F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HMLCPHOH_01494 1.9e-65 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HMLCPHOH_01495 2.1e-67 yqhY S protein conserved in bacteria
HMLCPHOH_01496 1.5e-255 accC 6.3.4.14, 6.4.1.2 I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
HMLCPHOH_01497 1.5e-64 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
HMLCPHOH_01498 9.9e-91 spoIIIAH S SpoIIIAH-like protein
HMLCPHOH_01499 6.9e-103 spoIIIAG S stage III sporulation protein AG
HMLCPHOH_01500 3.1e-102 spoIIIAF S Stage III sporulation protein AF (Spore_III_AF)
HMLCPHOH_01501 1.3e-197 spoIIIAE S stage III sporulation protein AE
HMLCPHOH_01502 2.3e-58 spoIIIAD S Stage III sporulation protein AD
HMLCPHOH_01503 7.6e-29 spoIIIAC S stage III sporulation protein AC
HMLCPHOH_01504 2.9e-85 spoIIIAB S Stage III sporulation protein
HMLCPHOH_01505 1.2e-171 spoIIIAA S stage III sporulation protein AA
HMLCPHOH_01506 7.9e-37 yqhV S Protein of unknown function (DUF2619)
HMLCPHOH_01507 5.4e-98 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HMLCPHOH_01508 8.9e-174 yqhT 3.4.11.9, 3.4.13.9 E COG0006 Xaa-Pro aminopeptidase
HMLCPHOH_01509 1.5e-77 aroQ 4.2.1.10 E Catalyzes a trans-dehydration via an enolate intermediate
HMLCPHOH_01510 2.3e-93 yqhR S Conserved membrane protein YqhR
HMLCPHOH_01511 2.1e-174 yqhQ S Protein of unknown function (DUF1385)
HMLCPHOH_01512 2.2e-61 yqhP
HMLCPHOH_01513 8.1e-165 yqhO S esterase of the alpha-beta hydrolase superfamily
HMLCPHOH_01514 9.4e-74 mntR K Involved in manganese homeostasis. Might activate the transcription of the mntABCD operon
HMLCPHOH_01515 5.2e-161 lipM 6.3.1.20 H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation
HMLCPHOH_01516 2.3e-63 yqhL P COG0607 Rhodanese-related sulfurtransferase
HMLCPHOH_01517 2.8e-287 gcvPB 1.4.4.2 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HMLCPHOH_01518 3.4e-255 gcvPA 1.4.4.2 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HMLCPHOH_01519 1.8e-206 gcvT 1.4.4.2, 2.1.2.10 E The glycine cleavage system catalyzes the degradation of glycine
HMLCPHOH_01520 0.0 yqhH L COG0553 Superfamily II DNA RNA helicases, SNF2 family
HMLCPHOH_01521 2.5e-152 yqhG S Bacterial protein YqhG of unknown function
HMLCPHOH_01522 1.2e-24 sinI S Anti-repressor SinI
HMLCPHOH_01523 1e-54 sinR K transcriptional
HMLCPHOH_01524 1.9e-141 tasA S Cell division protein FtsN
HMLCPHOH_01525 2.5e-58 sipW 3.4.21.89 U Signal peptidase
HMLCPHOH_01526 2.8e-113 yqxM
HMLCPHOH_01527 7.3e-54 yqzG S Protein of unknown function (DUF3889)
HMLCPHOH_01528 1.4e-26 yqzE S YqzE-like protein
HMLCPHOH_01529 3.7e-42 S ComG operon protein 7
HMLCPHOH_01530 5.5e-49 comGF U Putative Competence protein ComGF
HMLCPHOH_01531 1.1e-59 comGE
HMLCPHOH_01532 4.4e-71 gspH NU protein transport across the cell outer membrane
HMLCPHOH_01533 1.4e-47 comGC U Required for transformation and DNA binding
HMLCPHOH_01534 1.6e-175 comGB NU COG1459 Type II secretory pathway, component PulF
HMLCPHOH_01535 3.9e-201 comGA NU COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HMLCPHOH_01537 7.2e-175 corA P Mg2 transporter protein
HMLCPHOH_01538 5.2e-240 corC1 S COG1253 Hemolysins and related proteins containing CBS domains
HMLCPHOH_01539 1.7e-151 yqhA T COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
HMLCPHOH_01541 2.7e-64 yqgZ 1.20.4.1 P Belongs to the ArsC family
HMLCPHOH_01542 1.8e-37 yqgY S Protein of unknown function (DUF2626)
HMLCPHOH_01543 1.9e-123 ycbL 3.1.2.6 S COG0491 Zn-dependent hydrolases, including glyoxylases
HMLCPHOH_01544 8.9e-23 yqgW S Protein of unknown function (DUF2759)
HMLCPHOH_01545 6.9e-50 yqgV S Thiamine-binding protein
HMLCPHOH_01546 2.7e-199 yqgU
HMLCPHOH_01547 1.4e-222 yqgT 3.4.19.11 E Gamma-D-glutamyl-L-diamino acid endopeptidase
HMLCPHOH_01548 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
HMLCPHOH_01549 5.2e-181 glcK 2.7.1.2 G Glucokinase
HMLCPHOH_01550 3.1e-33 yqgQ S Protein conserved in bacteria
HMLCPHOH_01551 1.4e-268 gluP 3.4.21.105 O membrane protein (homolog of Drosophila rhomboid)
HMLCPHOH_01552 2.5e-09 yqgO
HMLCPHOH_01553 2.7e-105 ygfA 6.3.3.2 H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HMLCPHOH_01554 9.4e-21 rpmG J Belongs to the bacterial ribosomal protein bL33 family
HMLCPHOH_01555 3.2e-203 yqgM 2.4.1.11, 2.4.1.18 GH57,GT4 M Glycosyl transferases group 1
HMLCPHOH_01557 9.2e-51 yqzD
HMLCPHOH_01558 1.9e-75 yqzC S YceG-like family
HMLCPHOH_01559 9.8e-146 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
HMLCPHOH_01560 6.4e-148 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
HMLCPHOH_01561 4.4e-158 pstA P Phosphate transport system permease
HMLCPHOH_01562 1.3e-160 pstC P probably responsible for the translocation of the substrate across the membrane
HMLCPHOH_01563 5.3e-151 pstS P Phosphate
HMLCPHOH_01564 0.0 pbpA 3.4.16.4 M penicillin-binding protein
HMLCPHOH_01565 2.5e-231 yqgE EGP Major facilitator superfamily
HMLCPHOH_01566 6.3e-116 sodA 1.15.1.1 P radicals which are normally produced within the cells and which are toxic to biological systems
HMLCPHOH_01567 4e-73 yqgC S protein conserved in bacteria
HMLCPHOH_01568 8.5e-134 yqgB S Protein of unknown function (DUF1189)
HMLCPHOH_01569 2.2e-75 yqgA
HMLCPHOH_01570 5.2e-47 yqfZ M LysM domain
HMLCPHOH_01571 2.8e-202 ispG 1.17.7.1, 1.17.7.3 I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HMLCPHOH_01572 4.3e-62 yqfX S membrane
HMLCPHOH_01573 1.2e-108 yqfW S Belongs to the 5'(3')-deoxyribonucleotidase family
HMLCPHOH_01574 1.9e-77 zur P Belongs to the Fur family
HMLCPHOH_01575 1.6e-157 yqfU S Uncharacterized protein conserved in bacteria (DUF2179)
HMLCPHOH_01576 2.1e-36 yqfT S Protein of unknown function (DUF2624)
HMLCPHOH_01577 8.8e-167 nfo 3.1.21.2 L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HMLCPHOH_01578 1.7e-243 cshB 3.6.4.13 JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
HMLCPHOH_01579 2.9e-14 yqfQ S YqfQ-like protein
HMLCPHOH_01580 2.6e-177 ispH 1.17.7.4, 2.7.4.25 IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HMLCPHOH_01581 5.1e-212 yqfO 3.5.4.16 S Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HMLCPHOH_01582 6.1e-117 trmK 2.1.1.217 S SAM-dependent methyltransferase
HMLCPHOH_01583 1.6e-61 cccA C COG2010 Cytochrome c, mono- and diheme variants
HMLCPHOH_01584 1.2e-200 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
HMLCPHOH_01585 0.0 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
HMLCPHOH_01586 4.5e-88 yaiI S Belongs to the UPF0178 family
HMLCPHOH_01587 5.8e-149 yqfL 2.7.11.33, 2.7.4.28 S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation
HMLCPHOH_01588 4.5e-112 ccpN K CBS domain
HMLCPHOH_01589 0.0 glyS 6.1.1.14 J Glycyl-tRNA synthetase beta subunit
HMLCPHOH_01590 3.3e-174 glyQ 6.1.1.14 J glycyl-tRNA synthetase alpha subunit
HMLCPHOH_01591 4.8e-145 recO L Involved in DNA repair and RecF pathway recombination
HMLCPHOH_01592 8.4e-19 S YqzL-like protein
HMLCPHOH_01593 3.1e-167 era S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HMLCPHOH_01594 7.1e-71 cdd 2.4.2.2, 3.5.4.5 F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
HMLCPHOH_01595 1.6e-61 dgkA 2.7.1.107, 2.7.1.66 M Diacylglycerol kinase
HMLCPHOH_01596 5.1e-81 ybeY 2.6.99.2, 3.5.4.5 S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HMLCPHOH_01597 0.0 yqfF S membrane-associated HD superfamily hydrolase
HMLCPHOH_01599 1.1e-175 phoH T Phosphate starvation-inducible protein PhoH
HMLCPHOH_01600 1.5e-185 yqfD 3.1.3.102, 3.1.3.104 S Stage IV sporulation
HMLCPHOH_01601 2.7e-45 yqfC S sporulation protein YqfC
HMLCPHOH_01602 6e-25 yqfB
HMLCPHOH_01603 4.3e-122 yqfA S UPF0365 protein
HMLCPHOH_01604 5.4e-229 yqeZ O COG1030 Membrane-bound serine protease (ClpP class)
HMLCPHOH_01605 2.5e-61 yqeY S Yqey-like protein
HMLCPHOH_01606 1.2e-19 rpsU J Belongs to the bacterial ribosomal protein bS21 family
HMLCPHOH_01607 1.6e-158 yqeW P COG1283 Na phosphate symporter
HMLCPHOH_01608 2.1e-260 yqeV 2.8.4.5 J ribosomal protein S12 methylthiotransferase
HMLCPHOH_01609 1.4e-141 rsmE 2.1.1.193 J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
HMLCPHOH_01610 5.4e-175 prmA J Methylates ribosomal protein L11
HMLCPHOH_01611 4.2e-182 dnaJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
HMLCPHOH_01612 0.0 dnaK O Heat shock 70 kDa protein
HMLCPHOH_01613 3.8e-75 grpE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HMLCPHOH_01614 4.7e-188 hrcA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
HMLCPHOH_01615 4.8e-218 hemN H Involved in the biosynthesis of porphyrin-containing compound
HMLCPHOH_01616 0.0 lepA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
HMLCPHOH_01617 1e-54 yqxA S Protein of unknown function (DUF3679)
HMLCPHOH_01618 6.9e-223 spoIIP M stage II sporulation protein P
HMLCPHOH_01619 1.3e-204 gpr 3.4.24.78 C Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HMLCPHOH_01620 9.7e-37 rpsT J Binds directly to 16S ribosomal RNA
HMLCPHOH_01621 1.1e-189 holA 2.7.7.7 L DNA polymerase III delta subunit
HMLCPHOH_01622 4.1e-15 S YqzM-like protein
HMLCPHOH_01623 0.0 comEC S Competence protein ComEC
HMLCPHOH_01624 2.1e-105 comEB 3.5.4.12 F ComE operon protein 2
HMLCPHOH_01625 3e-105 wza L COG1555 DNA uptake protein and related DNA-binding proteins
HMLCPHOH_01626 8.4e-148 comER E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HMLCPHOH_01627 2.9e-139 yqeM Q Methyltransferase
HMLCPHOH_01628 6.9e-62 rsfS J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
HMLCPHOH_01629 7.4e-103 nadD 2.7.6.3, 2.7.7.18 H HD superfamily hydrolase involved in NAD metabolism
HMLCPHOH_01630 2.7e-108 nadD 2.7.7.18, 3.6.1.55 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HMLCPHOH_01631 2.1e-45 yhbY J RNA-binding protein containing KH domain, possibly ribosomal protein
HMLCPHOH_01632 2.7e-157 aroE 1.1.1.25 E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HMLCPHOH_01633 9.1e-214 yqeH S In Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis
HMLCPHOH_01634 5.3e-95 yqeG S hydrolase of the HAD superfamily
HMLCPHOH_01636 6.2e-142 yqeF E GDSL-like Lipase/Acylhydrolase
HMLCPHOH_01637 2.1e-137 xlyA 3.5.1.28 M n-acetylmuramoyl-L-alanine amidase
HMLCPHOH_01638 4.7e-106 yqeD S SNARE associated Golgi protein
HMLCPHOH_01639 1.2e-171 gnd 1.1.1.343, 1.1.1.44 G 6-phosphogluconate dehydrogenase
HMLCPHOH_01640 2.3e-133 yqeB
HMLCPHOH_01641 1.1e-74 nucB M Deoxyribonuclease NucA/NucB
HMLCPHOH_01642 3.1e-125 sigK K sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HMLCPHOH_01643 2e-68 psiE S Protein PsiE homolog
HMLCPHOH_01644 9e-237 yrkQ T Histidine kinase
HMLCPHOH_01645 1.1e-127 T Transcriptional regulator
HMLCPHOH_01646 8.2e-224 yrkO P Protein of unknown function (DUF418)
HMLCPHOH_01647 6e-105 yrkN K Acetyltransferase (GNAT) family
HMLCPHOH_01648 1.5e-97 ywrO S Flavodoxin-like fold
HMLCPHOH_01649 2.8e-79 S Protein of unknown function with HXXEE motif
HMLCPHOH_01650 4.3e-117 yrkJ S membrane transporter protein
HMLCPHOH_01651 2.4e-36 yrkI O Belongs to the sulfur carrier protein TusA family
HMLCPHOH_01652 2.3e-212 yrkH P Rhodanese Homology Domain
HMLCPHOH_01653 1.7e-99 yrkF OP Belongs to the sulfur carrier protein TusA family
HMLCPHOH_01654 5.1e-84 yrkE O DsrE/DsrF/DrsH-like family
HMLCPHOH_01655 7.8e-39 yrkD S protein conserved in bacteria
HMLCPHOH_01656 2.6e-108 yrkC G Cupin domain
HMLCPHOH_01657 4.8e-151 bltR K helix_turn_helix, mercury resistance
HMLCPHOH_01658 3.5e-211 blt EGP Major facilitator Superfamily
HMLCPHOH_01659 1.4e-83 bltD 2.3.1.57 K FR47-like protein
HMLCPHOH_01660 4.5e-236 corC1 S COG1253 Hemolysins and related proteins containing CBS domains
HMLCPHOH_01661 2.1e-17 S YrzO-like protein
HMLCPHOH_01662 1.7e-171 yrdR EG EamA-like transporter family
HMLCPHOH_01663 5.9e-160 yrdQ K Transcriptional regulator
HMLCPHOH_01664 2e-199 trkA P Oxidoreductase
HMLCPHOH_01665 3.5e-158 czcD P COG1230 Co Zn Cd efflux system component
HMLCPHOH_01666 1.3e-66 yodA S tautomerase
HMLCPHOH_01667 2.5e-161 gltR K LysR substrate binding domain
HMLCPHOH_01669 1.1e-226 brnQ E Component of the transport system for branched-chain amino acids
HMLCPHOH_01670 2.5e-50 azlD E Branched-chain amino acid transport protein (AzlD)
HMLCPHOH_01671 2.8e-137 azlC E AzlC protein
HMLCPHOH_01672 2.2e-79 bkdR K helix_turn_helix ASNC type
HMLCPHOH_01673 4.1e-46 yrdF K ribonuclease inhibitor
HMLCPHOH_01674 4.1e-231 cypA C Cytochrome P450
HMLCPHOH_01676 3.1e-101 yrdC 3.5.1.19 Q Isochorismatase family
HMLCPHOH_01677 1.9e-57 S Protein of unknown function (DUF2568)
HMLCPHOH_01678 1.2e-91 yrdA S DinB family
HMLCPHOH_01679 7.6e-168 aadK G Streptomycin adenylyltransferase
HMLCPHOH_01680 1.5e-194 yrpB 1.13.12.16 S COG2070 Dioxygenases related to 2-nitropropane dioxygenase
HMLCPHOH_01681 7.4e-149 murI 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
HMLCPHOH_01682 3e-125 yrpD S Domain of unknown function, YrpD
HMLCPHOH_01684 5.4e-117 adcA S ZinT (YodA) periplasmic lipocalin-like zinc-recruitment
HMLCPHOH_01685 6.3e-96 sigZ K Belongs to the sigma-70 factor family. ECF subfamily
HMLCPHOH_01686 4.5e-188 yrpG C Aldo/keto reductase family
HMLCPHOH_01687 9.5e-226 yraO C Citrate transporter
HMLCPHOH_01688 1.2e-163 yraN K Transcriptional regulator
HMLCPHOH_01689 2.4e-206 yraM S PrpF protein
HMLCPHOH_01691 2.7e-157 csn 3.2.1.132 M Aids in the defense against invading fungal pathogens by degrading their cell wall chitosan
HMLCPHOH_01692 7.6e-42 yraL S COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HMLCPHOH_01693 3.2e-155 S Alpha beta hydrolase
HMLCPHOH_01694 1.7e-60 T sh3 domain protein
HMLCPHOH_01695 2.4e-61 T sh3 domain protein
HMLCPHOH_01696 1.3e-66 E Glyoxalase-like domain
HMLCPHOH_01697 5.3e-37 yraG
HMLCPHOH_01698 6.4e-63 yraF M Spore coat protein
HMLCPHOH_01699 2.9e-223 adhB 1.1.1.1, 1.1.1.14, 1.1.1.284, 1.2.1.46 E COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
HMLCPHOH_01700 2.6e-26 yraE
HMLCPHOH_01701 1.1e-49 yraD M Spore coat protein
HMLCPHOH_01702 4.3e-47 yraB K helix_turn_helix, mercury resistance
HMLCPHOH_01703 3.2e-29 yphJ 4.1.1.44 S peroxiredoxin activity
HMLCPHOH_01704 1.9e-200 adhA 1.1.1.1 C alcohol dehydrogenase
HMLCPHOH_01705 5e-90 yhbO 1.11.1.6, 3.5.1.124 S protease
HMLCPHOH_01706 0.0 sacC 3.2.1.26, 3.2.1.65, 3.2.1.80 GH32 G Belongs to the glycosyl hydrolase 32 family
HMLCPHOH_01707 1.5e-152 manZ G COG3716 Phosphotransferase system, mannose fructose N-acetylgalactosamine-specific component IID
HMLCPHOH_01708 4.9e-116 manY G COG3715 Phosphotransferase system, mannose fructose N-acetylgalactosamine-specific component IIC
HMLCPHOH_01709 6.3e-82 levE 2.7.1.202 G PTS system mannose fructose sorbose family
HMLCPHOH_01710 3.9e-75 levD 2.7.1.202 G PTS system fructose IIA component
HMLCPHOH_01711 0.0 levR K PTS system fructose IIA component
HMLCPHOH_01712 1.6e-255 cycA E COG1113 Gamma-aminobutyrate permease and related permeases
HMLCPHOH_01713 3.6e-106 yrhP E LysE type translocator
HMLCPHOH_01714 1.1e-150 yrhO K Archaeal transcriptional regulator TrmB
HMLCPHOH_01715 4.3e-86 sigV K Belongs to the sigma-70 factor family. ECF subfamily
HMLCPHOH_01716 1.7e-151 rsiV S Protein of unknown function (DUF3298)
HMLCPHOH_01717 0.0 yrhL I Acyltransferase family
HMLCPHOH_01718 1.5e-46 yrhK S YrhK-like protein
HMLCPHOH_01719 0.0 cypD 1.14.14.1, 1.6.2.4 C Belongs to the cytochrome P450 family
HMLCPHOH_01720 4.8e-105 Z012_03230 K Tetracycline repressor, C-terminal all-alpha domain
HMLCPHOH_01721 4.5e-97 yrhH Q methyltransferase
HMLCPHOH_01724 1.8e-142 focA P Formate nitrite
HMLCPHOH_01725 7.8e-61 yrhF S Uncharacterized conserved protein (DUF2294)
HMLCPHOH_01726 0.0 fdhA 1.17.1.10, 1.17.1.9 C formate dehydrogenase (NAD+) activity
HMLCPHOH_01727 1.4e-78 yrhD S Protein of unknown function (DUF1641)
HMLCPHOH_01728 4.6e-35 yrhC S YrhC-like protein
HMLCPHOH_01729 2.6e-211 mccB 2.5.1.48, 4.4.1.1, 4.4.1.2, 4.4.1.8 E cystathionine
HMLCPHOH_01730 1.2e-171 mccA 2.5.1.134, 2.5.1.47 E Cysteine synthase
HMLCPHOH_01731 4.2e-124 mtnN 3.2.2.9 E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HMLCPHOH_01732 1.2e-120 yrrT 4.4.1.21 Q Could be a S-adenosyl-L-methionine-dependent methyltransferase
HMLCPHOH_01733 3.5e-26 yrzA S Protein of unknown function (DUF2536)
HMLCPHOH_01734 4.2e-63 yrrS S Protein of unknown function (DUF1510)
HMLCPHOH_01735 0.0 pbpI 3.4.16.4 M Penicillin-binding Protein
HMLCPHOH_01736 2.4e-78 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
HMLCPHOH_01737 4.7e-114 udk 2.7.1.48 F Cytidine monophosphokinase
HMLCPHOH_01738 2.7e-246 yegQ O COG0826 Collagenase and related proteases
HMLCPHOH_01739 7.8e-174 yegQ O Peptidase U32
HMLCPHOH_01740 5.9e-120 yrrM 2.1.1.104 S O-methyltransferase
HMLCPHOH_01741 1.6e-183 mltG S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HMLCPHOH_01742 1.2e-45 yrzB S Belongs to the UPF0473 family
HMLCPHOH_01743 2.1e-70 yqgF L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HMLCPHOH_01744 1.7e-41 yrzL S Belongs to the UPF0297 family
HMLCPHOH_01745 0.0 alaS 6.1.1.7 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HMLCPHOH_01746 2.7e-170 yrrI S AI-2E family transporter
HMLCPHOH_01747 1.3e-131 glnQ 3.6.3.21 E COG1126 ABC-type polar amino acid transport system, ATPase component
HMLCPHOH_01748 5.1e-145 glnH ET Belongs to the bacterial solute-binding protein 3 family
HMLCPHOH_01749 3.6e-109 gluC P ABC transporter
HMLCPHOH_01750 7.6e-107 glnP P ABC transporter
HMLCPHOH_01751 8e-08 S Protein of unknown function (DUF3918)
HMLCPHOH_01752 9.8e-31 yrzR
HMLCPHOH_01753 1.8e-83 yrrD S protein conserved in bacteria
HMLCPHOH_01754 0.0 recD2 3.1.11.5 L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
HMLCPHOH_01755 1.4e-15 S COG0457 FOG TPR repeat
HMLCPHOH_01756 2.3e-220 mnmA 2.8.1.13 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
HMLCPHOH_01757 4.7e-213 iscS 2.8.1.7 E Cysteine desulfurase
HMLCPHOH_01758 1.2e-70 cymR K Transcriptional regulator
HMLCPHOH_01759 2e-236 rarA L COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase
HMLCPHOH_01760 4e-136 yrvM H COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1
HMLCPHOH_01761 0.0 aspS 6.1.1.12 J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HMLCPHOH_01762 5.2e-245 hisS 6.1.1.21 J histidyl-tRNA synthetase
HMLCPHOH_01764 3.9e-263 lytH 3.5.1.28 M COG3103 SH3 domain protein
HMLCPHOH_01765 2.9e-70 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
HMLCPHOH_01766 0.0 relA 2.7.6.5 KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HMLCPHOH_01767 5.9e-91 apt 2.4.2.22, 2.4.2.7 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HMLCPHOH_01768 0.0 recJ L Single-stranded-DNA-specific exonuclease RecJ
HMLCPHOH_01769 1.3e-48 yrvD S Lipopolysaccharide assembly protein A domain
HMLCPHOH_01770 1.7e-87 yrvC P regulatory, ligand-binding protein related to C-terminal domains of K channels
HMLCPHOH_01771 0.0 secF U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HMLCPHOH_01772 9.4e-49 yrzD S Post-transcriptional regulator
HMLCPHOH_01773 5.7e-270 spoVB S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
HMLCPHOH_01774 2.2e-114 yrbG S membrane
HMLCPHOH_01775 1.2e-74 yrzE S Protein of unknown function (DUF3792)
HMLCPHOH_01776 8e-39 yajC U Preprotein translocase subunit YajC
HMLCPHOH_01777 5.2e-228 tgt 2.4.2.29 F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
HMLCPHOH_01778 2e-194 queA 2.4.99.17 J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HMLCPHOH_01779 2.6e-18 yrzS S Protein of unknown function (DUF2905)
HMLCPHOH_01780 6.6e-187 ruvB 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
HMLCPHOH_01781 1.6e-106 ruvA 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
HMLCPHOH_01782 4.8e-93 bofC S BofC C-terminal domain
HMLCPHOH_01783 5.3e-253 csbX EGP Major facilitator Superfamily
HMLCPHOH_01784 1.3e-193 iolG 1.1.1.18, 1.1.1.369 S Oxidoreductase family, NAD-binding Rossmann fold
HMLCPHOH_01785 6.5e-119 yrzF T serine threonine protein kinase
HMLCPHOH_01787 2.6e-35 S Family of unknown function (DUF5412)
HMLCPHOH_01788 1.8e-262 alsT E Sodium alanine symporter
HMLCPHOH_01789 1.9e-127 yebC K transcriptional regulatory protein
HMLCPHOH_01790 3.8e-49 S Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
HMLCPHOH_01791 9.8e-158 safA M spore coat assembly protein SafA
HMLCPHOH_01792 2.8e-215 nadA 2.5.1.72 H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HMLCPHOH_01793 5.4e-161 nadC 1.4.3.16, 2.4.2.19 H Belongs to the NadC ModD family
HMLCPHOH_01794 2.7e-307 nadB 1.3.5.4, 1.4.3.16 H Catalyzes the oxidation of L-aspartate to iminoaspartate
HMLCPHOH_01795 1.2e-230 nifS 2.8.1.7 E Cysteine desulfurase
HMLCPHOH_01796 3.6e-94 niaR S small molecule binding protein (contains 3H domain)
HMLCPHOH_01797 3.4e-163 pheA 4.2.1.51 E Prephenate dehydratase
HMLCPHOH_01798 2.2e-73 pheB 5.4.99.5 S Belongs to the UPF0735 family
HMLCPHOH_01799 1.5e-231 obg S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HMLCPHOH_01800 1.5e-106 spo0B T Sporulation initiation phospho-transferase B, C-terminal
HMLCPHOH_01801 2.5e-46 rpmA J Belongs to the bacterial ribosomal protein bL27 family
HMLCPHOH_01802 4.1e-56 ysxB J ribosomal protein
HMLCPHOH_01803 5.8e-49 rplU J This protein binds to 23S rRNA in the presence of protein L20
HMLCPHOH_01804 9.2e-161 spoIVFB S Stage IV sporulation protein
HMLCPHOH_01805 3.8e-145 spoIVFA M COG0739 Membrane proteins related to metalloendopeptidases
HMLCPHOH_01806 2.5e-144 minD D Belongs to the ParA family
HMLCPHOH_01807 1.4e-108 minC D Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization
HMLCPHOH_01808 1.4e-84 mreD M shape-determining protein
HMLCPHOH_01809 2.8e-157 mreC M Involved in formation and maintenance of cell shape
HMLCPHOH_01810 1.8e-184 mreB D Rod shape-determining protein MreB
HMLCPHOH_01811 5.4e-51 radC E Belongs to the UPF0758 family
HMLCPHOH_01812 1.9e-08
HMLCPHOH_01814 2.3e-16 K Helix-turn-helix domain
HMLCPHOH_01816 2.4e-118 xlyA 3.5.1.28 M N-acetylmuramoyl-L-alanine amidase
HMLCPHOH_01817 7.9e-57 S Pfam:Phage_holin_4_1
HMLCPHOH_01818 5e-95 3.1.4.46, 5.4.2.11 C glycerophosphoryl diester phosphodiesterase
HMLCPHOH_01820 1e-12
HMLCPHOH_01821 8.2e-85
HMLCPHOH_01822 0.0 S Peptidase_G2, IMC autoproteolytic cleavage domain
HMLCPHOH_01823 1e-108 mur1 NU Prophage endopeptidase tail
HMLCPHOH_01824 7.2e-46 S Phage tail protein
HMLCPHOH_01825 4.1e-229 D Phage tail tape measure protein
HMLCPHOH_01828 8.1e-28 S Pfam:Phage_TTP_1
HMLCPHOH_01829 7.2e-10
HMLCPHOH_01830 3.9e-31 S Bacteriophage HK97-gp10, putative tail-component
HMLCPHOH_01831 2.7e-28 S Phage head-tail joining protein
HMLCPHOH_01832 2.6e-22 S Phage gp6-like head-tail connector protein
HMLCPHOH_01833 2.2e-08
HMLCPHOH_01834 1.1e-135 S capsid protein
HMLCPHOH_01835 5e-73 pi136 S Caudovirus prohead serine protease
HMLCPHOH_01836 1.3e-173 S portal protein
HMLCPHOH_01838 3.5e-260 terL S Terminase
HMLCPHOH_01839 1.5e-59 terS L Terminase, small subunit
HMLCPHOH_01840 4e-07
HMLCPHOH_01841 7.2e-17 S HNH endonuclease
HMLCPHOH_01842 7.9e-08
HMLCPHOH_01844 7.9e-48
HMLCPHOH_01845 2.3e-227 KL SNF2 family N-terminal domain
HMLCPHOH_01846 6.9e-32 S VRR_NUC
HMLCPHOH_01847 0.0 L Virulence-associated protein E
HMLCPHOH_01850 4.4e-304 2.7.7.7 L DNA polymerase A domain
HMLCPHOH_01851 2.4e-21
HMLCPHOH_01852 3.1e-85 S Protein of unknown function (DUF2815)
HMLCPHOH_01853 2.1e-163 L Protein of unknown function (DUF2800)
HMLCPHOH_01854 6.4e-10
HMLCPHOH_01855 1.3e-48
HMLCPHOH_01858 2.6e-08 plcR K helix-turn-helix
HMLCPHOH_01859 1.8e-64 S sequence-specific DNA binding
HMLCPHOH_01860 7e-72 S Pfam:Peptidase_M78
HMLCPHOH_01861 2.4e-230 S Recombinase
HMLCPHOH_01862 2.6e-68 radC E Belongs to the UPF0758 family
HMLCPHOH_01863 2.8e-102 maf D septum formation protein Maf
HMLCPHOH_01864 1.1e-168 spoIIB S Sporulation related domain
HMLCPHOH_01865 6.6e-85 comC 3.4.23.43 NOU COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases
HMLCPHOH_01866 4.3e-247 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
HMLCPHOH_01867 0.0 valS 6.1.1.9 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
HMLCPHOH_01868 1.6e-25
HMLCPHOH_01869 1.6e-199 ysxE S A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HMLCPHOH_01870 1.9e-226 spoVID M stage VI sporulation protein D
HMLCPHOH_01871 4.6e-249 hemL 5.4.3.8 H Glutamate-1-semialdehyde aminotransferase
HMLCPHOH_01872 5.6e-183 hemB 4.2.1.24 H Belongs to the ALAD family
HMLCPHOH_01873 4.4e-146 hemD 2.1.1.107, 4.2.1.75 H Uroporphyrinogen-III synthase
HMLCPHOH_01874 3e-173 hemC 2.1.1.107, 2.5.1.61, 4.2.1.75 H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
HMLCPHOH_01875 3.6e-146 hemX O cytochrome C
HMLCPHOH_01876 3.5e-247 hemA 1.2.1.70 H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HMLCPHOH_01877 1.4e-89 ysxD
HMLCPHOH_01878 1.2e-106 engB D Necessary for normal cell division and for the maintenance of normal septation
HMLCPHOH_01879 0.0 lon 3.4.21.53 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HMLCPHOH_01880 2.3e-311 lonB 2.7.7.7, 3.4.21.53 LO Belongs to the peptidase S16 family
HMLCPHOH_01881 3.4e-233 clpX O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HMLCPHOH_01882 8.3e-227 tig D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
HMLCPHOH_01883 2.3e-187 ysoA H Tetratricopeptide repeat
HMLCPHOH_01884 8.1e-116 leuD 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HMLCPHOH_01885 1.7e-276 leuC 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HMLCPHOH_01886 3.3e-200 leuB 1.1.1.85 CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
HMLCPHOH_01887 4e-292 leuA 2.3.3.13 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HMLCPHOH_01888 3.1e-192 ilvC 1.1.1.86 EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HMLCPHOH_01889 3.2e-84 ilvN 2.2.1.6 E Acetolactate synthase
HMLCPHOH_01890 0.0 ilvB 2.2.1.6 E Acetolactate synthase
HMLCPHOH_01892 7.6e-82 ysnE K acetyltransferase
HMLCPHOH_01893 9.1e-134 ysnF S protein conserved in bacteria
HMLCPHOH_01895 1.4e-92 ysnB S Phosphoesterase
HMLCPHOH_01896 4.5e-103 rdgB 3.6.1.66 F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HMLCPHOH_01897 1.8e-133 rph 2.7.7.56, 3.6.1.66 J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HMLCPHOH_01898 2.9e-196 gerM S COG5401 Spore germination protein
HMLCPHOH_01899 2.1e-154 murI 3.6.1.66, 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
HMLCPHOH_01900 2.3e-75 ysmB 2.4.2.28 K helix_turn_helix multiple antibiotic resistance protein
HMLCPHOH_01901 3.3e-30 gerE K Transcriptional regulator
HMLCPHOH_01902 1.6e-76 ybgC 3.1.2.23, 3.1.2.28 S thioesterase
HMLCPHOH_01903 4.6e-148 sdhB 1.3.5.1, 1.3.5.4 C succinate dehydrogenase
HMLCPHOH_01904 0.0 sdhA 1.3.5.1, 1.3.5.4 C succinate dehydrogenase
HMLCPHOH_01905 2.4e-107 sdhC C succinate dehydrogenase
HMLCPHOH_01906 1.2e-79 yslB S Protein of unknown function (DUF2507)
HMLCPHOH_01907 1.3e-216 lysC 1.1.1.3, 2.7.2.4 E Belongs to the aspartokinase family
HMLCPHOH_01908 0.0 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
HMLCPHOH_01909 2e-52 trxA O Belongs to the thioredoxin family
HMLCPHOH_01910 5.7e-304 xsa 3.2.1.55 GH51 G Alpha-L-arabinofuranosidase C-terminus
HMLCPHOH_01912 2.1e-177 etfA C Electron transfer flavoprotein
HMLCPHOH_01913 4.5e-135 etfB C Electron transfer flavoprotein
HMLCPHOH_01914 3.1e-136 fadB 4.2.1.17 I Belongs to the enoyl-CoA hydratase isomerase family
HMLCPHOH_01915 2.7e-100 fadR K Transcriptional regulator
HMLCPHOH_01916 0.0 lcfA 6.2.1.3 IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
HMLCPHOH_01917 7.3e-68 yshE S membrane
HMLCPHOH_01918 0.0 mutS2 L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
HMLCPHOH_01919 0.0 polX L COG1796 DNA polymerase IV (family X)
HMLCPHOH_01920 1.3e-85 cvpA S membrane protein, required for colicin V production
HMLCPHOH_01921 2.4e-40 zapA D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HMLCPHOH_01922 4e-170 rnhC 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HMLCPHOH_01923 0.0 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HMLCPHOH_01924 2.8e-196 pheS 6.1.1.20 J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HMLCPHOH_01925 3.1e-133 spoU 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HMLCPHOH_01926 2.6e-32 sspI S Belongs to the SspI family
HMLCPHOH_01927 4.4e-208 ysfB KT regulator
HMLCPHOH_01928 7.2e-264 glcD 1.1.3.15 C Glycolate oxidase subunit
HMLCPHOH_01929 5.6e-258 glcF C Glycolate oxidase
HMLCPHOH_01930 3.6e-38 ysfE 4.4.1.5 E lactoylglutathione lyase activity
HMLCPHOH_01932 0.0 cstA T Carbon starvation protein
HMLCPHOH_01933 4.6e-301 abfA 3.2.1.55 GH51 G alpha-L-arabinofuranosidase activity
HMLCPHOH_01934 3.4e-144 araQ G transport system permease
HMLCPHOH_01935 1.4e-167 araP G carbohydrate transport
HMLCPHOH_01936 2.8e-254 araN G carbohydrate transport
HMLCPHOH_01937 5e-226 egsA 1.1.1.261 I Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is probably used for the synthesis of phosphoglycerolipids in Gram-positive bacterial species
HMLCPHOH_01938 4.1e-147 araL 3.1.3.41 G Haloacid dehalogenase-like hydrolase
HMLCPHOH_01939 8.4e-133 araD 4.1.2.17, 4.2.1.109, 5.1.3.4 G COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases
HMLCPHOH_01940 0.0 araB 2.7.1.16 C Belongs to the ribulokinase family
HMLCPHOH_01941 1.9e-294 araA 5.3.1.4 G Catalyzes the conversion of L-arabinose to L-ribulose
HMLCPHOH_01942 2.1e-190 abnA 3.2.1.99 GH43 G Belongs to the glycosyl hydrolase 43 family
HMLCPHOH_01943 4.5e-205 ysdC G COG1363 Cellulase M and related proteins
HMLCPHOH_01944 9.2e-68 ysdB S Sigma-w pathway protein YsdB
HMLCPHOH_01945 7.5e-45 ysdA S Membrane
HMLCPHOH_01946 3.6e-58 rplT J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HMLCPHOH_01947 9e-27 rpmI J Belongs to the bacterial ribosomal protein bL35 family
HMLCPHOH_01948 3.3e-86 infC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HMLCPHOH_01950 2.4e-111 lrgB M Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses
HMLCPHOH_01951 2.2e-49 lrgA S Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses
HMLCPHOH_01952 6.3e-131 lytT T COG3279 Response regulator of the LytR AlgR family
HMLCPHOH_01953 0.0 lytS 2.7.13.3 T Histidine kinase
HMLCPHOH_01954 1.5e-149 ysaA S HAD-hyrolase-like
HMLCPHOH_01955 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HMLCPHOH_01956 3.8e-159 ytxC S YtxC-like family
HMLCPHOH_01957 4.9e-111 ytxB S SNARE associated Golgi protein
HMLCPHOH_01958 3e-173 dnaI L Primosomal protein DnaI
HMLCPHOH_01959 3.5e-266 dnaB L Membrane attachment protein
HMLCPHOH_01960 1.1e-80 nrdR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HMLCPHOH_01961 2e-67 speH 4.1.1.50 E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HMLCPHOH_01962 2.8e-193 gapB 1.2.1.12, 1.2.1.59 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
HMLCPHOH_01963 9.9e-67 ytcD K Transcriptional regulator
HMLCPHOH_01964 4.9e-205 ytbD EGP Major facilitator Superfamily
HMLCPHOH_01965 8.9e-161 ytbE S reductase
HMLCPHOH_01966 7.6e-98 coaE 2.7.1.24 F Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HMLCPHOH_01967 1.1e-107 ytaF P Probably functions as a manganese efflux pump
HMLCPHOH_01968 2e-157 fpg 3.2.2.23, 4.2.99.18 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
HMLCPHOH_01969 0.0 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HMLCPHOH_01970 0.0 phoR 2.7.13.3 T Signal transduction histidine kinase
HMLCPHOH_01971 2.2e-131 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HMLCPHOH_01972 1.1e-170 mdh 1.1.1.37 C Catalyzes the reversible oxidation of malate to oxaloacetate
HMLCPHOH_01973 1.8e-242 icd 1.1.1.42 C isocitrate
HMLCPHOH_01974 4.7e-210 citZ 2.3.3.1 C Belongs to the citrate synthase family
HMLCPHOH_01975 4.7e-71 yeaL S membrane
HMLCPHOH_01976 2.6e-192 ytvI S sporulation integral membrane protein YtvI
HMLCPHOH_01977 1.8e-63 fxsA S COG3030 Protein affecting phage T7 exclusion by the F plasmid
HMLCPHOH_01978 0.0 pyk 2.7.1.40, 2.7.7.4 G Belongs to the pyruvate kinase family
HMLCPHOH_01979 3.4e-180 pfkA 2.7.1.11 F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
HMLCPHOH_01980 4.3e-183 accA 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
HMLCPHOH_01981 8.4e-162 accD 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HMLCPHOH_01982 1.5e-225 ytsJ 1.1.1.38 C Malate dehydrogenase
HMLCPHOH_01983 0.0 dnaE 2.7.7.7 L DNA polymerase
HMLCPHOH_01984 3.2e-56 ytrH S Sporulation protein YtrH
HMLCPHOH_01985 8.2e-69 ytrI
HMLCPHOH_01986 9.2e-29
HMLCPHOH_01987 7.8e-182 nrnA 3.1.13.3, 3.1.3.7 S COG0618 Exopolyphosphatase-related proteins
HMLCPHOH_01988 2.4e-47 ytpI S YtpI-like protein
HMLCPHOH_01989 8e-241 ytoI K transcriptional regulator containing CBS domains
HMLCPHOH_01990 1.2e-158 ytnM S membrane transporter protein
HMLCPHOH_01991 4.9e-240 ytnL 3.5.1.47 E hydrolase activity
HMLCPHOH_01992 6.3e-128 ribF 2.7.1.26, 2.7.7.2 H Riboflavin kinase
HMLCPHOH_01993 1e-256 moxC C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HMLCPHOH_01994 2.9e-47 ytnI O COG0695 Glutaredoxin and related proteins
HMLCPHOH_01995 1.2e-185 ytmO C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HMLCPHOH_01996 1e-142 tcyN 3.6.3.21 E COG1126 ABC-type polar amino acid transport system, ATPase component
HMLCPHOH_01997 7.6e-121 tcyM U Binding-protein-dependent transport system inner membrane component
HMLCPHOH_01998 3.7e-123 tcyL P Binding-protein-dependent transport system inner membrane component
HMLCPHOH_01999 1.5e-149 tcyK M Bacterial periplasmic substrate-binding proteins
HMLCPHOH_02000 9.5e-152 tcyK ET Bacterial periplasmic substrate-binding proteins
HMLCPHOH_02001 1.5e-100 ytmI K Acetyltransferase (GNAT) domain
HMLCPHOH_02002 2.9e-173 ytlI K LysR substrate binding domain
HMLCPHOH_02003 1.7e-130 ytkL S Belongs to the UPF0173 family
HMLCPHOH_02004 1.1e-141 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HMLCPHOH_02006 3.1e-267 argH 4.3.2.1 E argininosuccinate lyase
HMLCPHOH_02007 2.3e-234 argG 6.3.4.5 E Belongs to the argininosuccinate synthase family. Type 1 subfamily
HMLCPHOH_02008 3.6e-88 moaB 2.7.7.75 H May be involved in the biosynthesis of molybdopterin
HMLCPHOH_02009 3.7e-221 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HMLCPHOH_02010 7e-165 ytxK 2.1.1.72 L DNA methylase
HMLCPHOH_02011 2.4e-89 tpx 1.11.1.15 O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HMLCPHOH_02012 8.7e-70 ytfJ S Sporulation protein YtfJ
HMLCPHOH_02013 5.6e-116 ytfI S Protein of unknown function (DUF2953)
HMLCPHOH_02014 1.3e-87 yteJ S RDD family
HMLCPHOH_02015 2.4e-181 sppA OU signal peptide peptidase SppA
HMLCPHOH_02016 2.2e-148 nadK 2.7.1.23 G Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HMLCPHOH_02017 0.0 ytcJ S amidohydrolase
HMLCPHOH_02018 2e-307 acsA 6.2.1.1, 6.2.1.2 I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases
HMLCPHOH_02019 2e-29 sspB S spore protein
HMLCPHOH_02020 3.5e-227 thiI 2.8.1.4 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HMLCPHOH_02021 2.2e-210 iscS2 2.8.1.7 E Cysteine desulfurase
HMLCPHOH_02022 4.9e-238 brnQ E Component of the transport system for branched-chain amino acids
HMLCPHOH_02023 4.1e-274 ezrA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HMLCPHOH_02024 1.6e-154 hisK 3.1.3.15 E COG1387 Histidinol phosphatase and related hydrolases of the PHP family
HMLCPHOH_02025 3.4e-109 yttP K Transcriptional regulator
HMLCPHOH_02026 1.2e-88 ytsP 1.8.4.14 T GAF domain-containing protein
HMLCPHOH_02027 0.0 ytrP 2.7.7.65 T COG2199 FOG GGDEF domain
HMLCPHOH_02028 2.5e-109 rpsD J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HMLCPHOH_02030 3.6e-238 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HMLCPHOH_02031 0.0 acsA 6.2.1.1 I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases
HMLCPHOH_02032 3.6e-122 acuA K Part of the acuABC operon, which is possibly involved in the breakdown of acetoin and butanediol. Acts as an acetyltransferase inactivating acetyl-CoA synthetase AcsA via acetylation at a Lys residue
HMLCPHOH_02033 1.6e-117 acuB S Domain in cystathionine beta-synthase and other proteins.
HMLCPHOH_02034 1.9e-225 acuC BQ histone deacetylase
HMLCPHOH_02035 1.4e-125 motS N Flagellar motor protein
HMLCPHOH_02036 7.1e-147 motA N flagellar motor
HMLCPHOH_02037 1.7e-182 ccpA K catabolite control protein A
HMLCPHOH_02038 4.9e-196 aroF 2.5.1.54, 5.4.99.5 E Catalyzes the formation of 3-deoxy-D-aribino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate and the formation of prephenate from chorismate
HMLCPHOH_02039 4.4e-55 ytxJ O Protein of unknown function (DUF2847)
HMLCPHOH_02040 6.6e-17 ytxH S COG4980 Gas vesicle protein
HMLCPHOH_02041 2.1e-17 ytxG S protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HMLCPHOH_02042 1.6e-254 mpl 6.3.2.4, 6.3.2.45, 6.3.2.8 M Belongs to the MurCDEF family
HMLCPHOH_02043 0.0 sftA D Belongs to the FtsK SpoIIIE SftA family
HMLCPHOH_02044 9.7e-109 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HMLCPHOH_02045 9.8e-149 ytpQ S Belongs to the UPF0354 family
HMLCPHOH_02046 2.1e-57 ytpP 2.7.1.180, 5.3.4.1 CO Thioredoxin
HMLCPHOH_02047 5.9e-79 ytoQ S Nucleoside 2-deoxyribosyltransferase YtoQ
HMLCPHOH_02048 4.7e-207 pepA 3.4.11.7 G COG1363 Cellulase M and related proteins
HMLCPHOH_02049 9.8e-52 ytzB S small secreted protein
HMLCPHOH_02050 0.0 sfcA 1.1.1.38 C Malate dehydrogenase
HMLCPHOH_02051 6.4e-151 ytnP S COG0491 Zn-dependent hydrolases, including glyoxylases
HMLCPHOH_02052 1.4e-121 trmB 2.1.1.297, 2.1.1.33 J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
HMLCPHOH_02053 2e-45 ytzH S YtzH-like protein
HMLCPHOH_02054 6.1e-151 ytmP 2.7.1.89 M Phosphotransferase
HMLCPHOH_02055 0.0 pulA 3.2.1.41 CBM48,GH13 G Belongs to the glycosyl hydrolase 13 family
HMLCPHOH_02056 2.9e-181 ytlR 2.7.1.91 I Diacylglycerol kinase catalytic domain
HMLCPHOH_02057 1.3e-165 ytlQ
HMLCPHOH_02058 4.3e-103 ligT 3.1.4.58, 3.5.1.42 J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HMLCPHOH_02059 8.6e-173 ytkP 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
HMLCPHOH_02060 7.1e-272 pepV 3.5.1.18 E Dipeptidase
HMLCPHOH_02061 7.2e-226 pbuO S permease
HMLCPHOH_02062 3.9e-207 ythQ U Bacterial ABC transporter protein EcsB
HMLCPHOH_02063 4.3e-132 ythP V ABC transporter
HMLCPHOH_02064 2.4e-33 ytzE K COG1349 Transcriptional regulators of sugar metabolism
HMLCPHOH_02065 2.6e-132 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
HMLCPHOH_02066 1.9e-281 ytgP S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
HMLCPHOH_02067 8.2e-232 ytfP S HI0933-like protein
HMLCPHOH_02068 3.4e-283 opuD M Belongs to the BCCT transporter (TC 2.A.15) family
HMLCPHOH_02069 3.1e-26 yteV S Sporulation protein Cse60
HMLCPHOH_02070 4.8e-117 yteU S Integral membrane protein
HMLCPHOH_02071 9.2e-258 yteT S Oxidoreductase family, C-terminal alpha/beta domain
HMLCPHOH_02072 4.6e-73 yteS G transport
HMLCPHOH_02073 4.7e-226 yteR 3.2.1.172 GH105 G unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins
HMLCPHOH_02074 2e-172 lplB G COG4209 ABC-type polysaccharide transport system, permease component
HMLCPHOH_02075 0.0 ytdP K Transcriptional regulator
HMLCPHOH_02076 1.2e-290 ytcQ G COG1653 ABC-type sugar transport system, periplasmic component
HMLCPHOH_02077 1.5e-150 ytcP G COG0395 ABC-type sugar transport system, permease component
HMLCPHOH_02078 9.6e-138 udh 1.1.1.203, 1.1.1.388 GM NAD dependent epimerase/dehydratase family
HMLCPHOH_02079 1.9e-225 bioI 1.14.14.46 C Cytochrome P450
HMLCPHOH_02080 2.2e-190 bioB 2.8.1.6 H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HMLCPHOH_02081 3.7e-128 bioD 6.3.3.3 H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HMLCPHOH_02082 1.4e-220 bioF 2.3.1.29, 2.3.1.47, 6.2.1.14 H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide
HMLCPHOH_02083 2.4e-261 bioA 2.6.1.105, 2.6.1.62 H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor
HMLCPHOH_02084 1.6e-142 bioW 2.3.1.47, 6.2.1.14 H Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
HMLCPHOH_02085 1.3e-173 ytaP S Acetyl xylan esterase (AXE1)
HMLCPHOH_02086 2.3e-190 msmR K Transcriptional regulator
HMLCPHOH_02087 2.3e-248 msmE G Bacterial extracellular solute-binding protein
HMLCPHOH_02088 3.7e-168 amyD P ABC transporter
HMLCPHOH_02089 1.5e-144 amyC P ABC transporter (permease)
HMLCPHOH_02090 4e-253 melA 3.2.1.122, 3.2.1.22, 3.2.1.86 GH4,GT4 G Family 4 glycosyl hydrolase
HMLCPHOH_02091 2.1e-51 ytwF P Sulfurtransferase
HMLCPHOH_02092 0.0 leuS 6.1.1.4 J Belongs to the class-I aminoacyl-tRNA synthetase family
HMLCPHOH_02093 7.7e-55 ytvB S Protein of unknown function (DUF4257)
HMLCPHOH_02094 6e-143 pfyP T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)
HMLCPHOH_02095 2.1e-211 yttB EGP Major facilitator Superfamily
HMLCPHOH_02096 1.8e-43 yttA 2.7.13.3 S Pfam Transposase IS66
HMLCPHOH_02097 0.0 bceB V ABC transporter (permease)
HMLCPHOH_02098 1.1e-138 bceA V ABC transporter, ATP-binding protein
HMLCPHOH_02099 5.6e-186 T PhoQ Sensor
HMLCPHOH_02100 5.2e-130 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HMLCPHOH_02101 8.5e-235 ytrF V COG0577 ABC-type antimicrobial peptide transport system, permease component
HMLCPHOH_02102 3.1e-127 ytrE V ABC transporter, ATP-binding protein
HMLCPHOH_02103 5.9e-148
HMLCPHOH_02104 6.1e-169 P ABC-2 family transporter protein
HMLCPHOH_02105 1.1e-161 ytrB P abc transporter atp-binding protein
HMLCPHOH_02106 5.1e-66 ytrA K GntR family transcriptional regulator
HMLCPHOH_02108 6.7e-41 ytzC S Protein of unknown function (DUF2524)
HMLCPHOH_02109 2.1e-190 yhcC S Fe-S oxidoreductase
HMLCPHOH_02110 3.3e-106 ytqB J Putative rRNA methylase
HMLCPHOH_02111 2e-216 ytpB 4.2.3.130 S Tetraprenyl-beta-curcumene synthase
HMLCPHOH_02112 3.3e-149 ytpA 3.1.1.5 I Alpha beta hydrolase
HMLCPHOH_02113 1.6e-59 ytoA S COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HMLCPHOH_02114 8.4e-257 ytnA E COG1113 Gamma-aminobutyrate permease and related permeases
HMLCPHOH_02115 0.0 asnB 6.3.5.4 E Asparagine synthase
HMLCPHOH_02116 4.3e-225 metK 2.5.1.6 H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HMLCPHOH_02117 2.2e-311 pckA 4.1.1.49 C Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HMLCPHOH_02118 1.2e-38 ytmB S Protein of unknown function (DUF2584)
HMLCPHOH_02119 5.5e-149 ytmA E COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases
HMLCPHOH_02120 5e-190 ytlA P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components
HMLCPHOH_02121 1.4e-144 ytlC P ABC transporter
HMLCPHOH_02122 1.8e-142 ytlD P COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component
HMLCPHOH_02123 2.8e-87 ytkD 3.6.1.55 L Belongs to the Nudix hydrolase family
HMLCPHOH_02124 5.4e-63 ytkC S Bacteriophage holin family
HMLCPHOH_02125 2.1e-76 dps P Belongs to the Dps family
HMLCPHOH_02127 3.6e-73 ytkA S YtkA-like
HMLCPHOH_02128 1.6e-87 luxS 4.4.1.21 T Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
HMLCPHOH_02129 5.7e-103 ytiB 4.2.1.1 P Reversible hydration of carbon dioxide
HMLCPHOH_02130 3.6e-41 rpmE2 J Ribosomal protein L31
HMLCPHOH_02131 4.7e-249 cydA 1.10.3.14 C oxidase, subunit
HMLCPHOH_02132 7.3e-189 cydB 1.10.3.14 C COG1294 Cytochrome bd-type quinol oxidase, subunit 2
HMLCPHOH_02133 1.1e-24 S Domain of Unknown Function (DUF1540)
HMLCPHOH_02134 1.4e-151 troD P 'COG1108 ABC-type Mn2 Zn2 transport systems, permease components'
HMLCPHOH_02135 3.2e-234 mntC P COG1108 ABC-type Mn2 Zn2 transport systems, permease components
HMLCPHOH_02136 1.2e-140 mntB P 'COG1121 ABC-type Mn Zn transport systems, ATPase component'
HMLCPHOH_02137 1.8e-170 troA P Belongs to the bacterial solute-binding protein 9 family
HMLCPHOH_02138 1.4e-214 menC 4.2.1.113 H Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)
HMLCPHOH_02139 2.4e-278 menE 6.2.1.26 H Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily
HMLCPHOH_02140 4.2e-155 menB 4.1.3.36 H Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HMLCPHOH_02141 3.8e-156 menH 4.2.99.20 S Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC)
HMLCPHOH_02142 0.0 menD 2.2.1.9 H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HMLCPHOH_02143 8.5e-273 menF 5.4.4.2 HQ Isochorismate synthase
HMLCPHOH_02144 2.6e-132 dksA T COG1734 DnaK suppressor protein
HMLCPHOH_02145 1e-153 galU 2.7.7.9 M Nucleotidyl transferase
HMLCPHOH_02146 1.5e-244 ugd 1.1.1.22 M Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HMLCPHOH_02147 3.9e-181 ytcB 5.1.3.2 M NAD-dependent epimerase dehydratase
HMLCPHOH_02148 3.6e-235 ytcC M Glycosyltransferase Family 4
HMLCPHOH_02150 2.3e-206 cotS S Seems to be required for the assembly of the CotSA protein in spores
HMLCPHOH_02151 1.8e-217 cotSA M Glycosyl transferases group 1
HMLCPHOH_02152 1.8e-206 cotI S Spore coat protein
HMLCPHOH_02153 9.9e-77 tspO T membrane
HMLCPHOH_02154 0.0 glgP 2.4.1.1 GT35 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
HMLCPHOH_02155 4.3e-288 glgA 2.4.1.21 GT5 G Synthesizes alpha-1,4-glucan chains using ADP-glucose
HMLCPHOH_02156 1.3e-177 glgD 2.4.1.21, 2.7.7.27 GT5 G Glucose-1-phosphate adenylyltransferase, GlgD subunit
HMLCPHOH_02157 3.6e-197 glgC 2.7.7.27 G Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HMLCPHOH_02158 0.0 glgB 2.4.1.18, 3.2.1.141, 3.2.1.20 CBM48,GH13,GH31 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HMLCPHOH_02167 7.8e-08
HMLCPHOH_02168 1.3e-09
HMLCPHOH_02175 2e-08
HMLCPHOH_02180 2.2e-187 yxbC 1.14.11.47 S A domain family that is part of the cupin metalloenzyme superfamily.
HMLCPHOH_02181 1.6e-85 yxbD 3.2.2.20 K Acetyltransferase (GNAT) domain
HMLCPHOH_02182 1.4e-248 alkH 1.2.1.3 C Belongs to the aldehyde dehydrogenase family
HMLCPHOH_02183 2.2e-215 yxbF K Bacterial regulatory proteins, tetR family
HMLCPHOH_02184 5.7e-152 IQ Enoyl-(Acyl carrier protein) reductase
HMLCPHOH_02186 0.0 htpG O Molecular chaperone. Has ATPase activity
HMLCPHOH_02187 2.3e-246 csbC EGP Major facilitator Superfamily
HMLCPHOH_02188 8.3e-48 yxcD S Protein of unknown function (DUF2653)
HMLCPHOH_02190 3.7e-176 iolS C Aldo keto reductase
HMLCPHOH_02191 3.3e-138 iolR K COG1349 Transcriptional regulators of sugar metabolism
HMLCPHOH_02192 1.4e-281 iolA 1.2.1.18, 1.2.1.27 C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
HMLCPHOH_02193 1.1e-155 iolB 5.3.1.30 G Involved in the isomerization of 5-deoxy-glucuronate (5DG) to 5-dehydro-2-deoxy-D-gluconate (DKG or 2-deoxy-5-keto-D- gluconate)
HMLCPHOH_02194 2.9e-179 iolC 2.7.1.92 G Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D- gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5- dehydro-2-deoxy-D-gluconate (DKGP)
HMLCPHOH_02195 0.0 iolD 3.7.1.22 E Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG)
HMLCPHOH_02196 2.1e-176 iolE 4.2.1.44 G Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol)
HMLCPHOH_02197 1.3e-235 iolF EGP Major facilitator Superfamily
HMLCPHOH_02198 1.4e-195 iolG 1.1.1.18, 1.1.1.369 S Involved in the oxidation of myo-inositol (MI) and D- chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively
HMLCPHOH_02199 8.6e-167 iolH G Xylose isomerase-like TIM barrel
HMLCPHOH_02200 1.2e-138 iolI 5.3.99.11 G Involved in the reversible interconverion of 2-keto-myo- inositol (2KMI, inosose or 2,4,6 3,5-pentahydroxycyclohexanone) to 1-keto-D-chiro-inositol (1KDCI or 2,3,5 4,6- pentahydroxycyclohexanone)
HMLCPHOH_02201 5.4e-161 iolJ 4.1.2.13, 4.1.2.29 F Produces dihydroxyacetone phosphate (DHAP or glycerone phosphate) and malonic semialdehyde (MSA or 3-oxopropanoate) from 6-phospho-5-dehydro-2-deoxy-D-gluconate (DKGP)
HMLCPHOH_02202 4.2e-124 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HMLCPHOH_02203 1.3e-182 T PhoQ Sensor
HMLCPHOH_02204 9.4e-141 yxdL V ABC transporter, ATP-binding protein
HMLCPHOH_02205 0.0 yxdM V ABC transporter (permease)
HMLCPHOH_02206 1.5e-58 yxeA S Protein of unknown function (DUF1093)
HMLCPHOH_02207 6e-177 fhuD P ABC transporter
HMLCPHOH_02208 8.5e-69
HMLCPHOH_02209 1.9e-16 yxeD
HMLCPHOH_02210 1.3e-20 yxeE
HMLCPHOH_02213 6.2e-151 yidA S hydrolases of the HAD superfamily
HMLCPHOH_02214 8.8e-192 yxeI 3.5.1.24 M Linear amide C-N hydrolases, choloylglycine hydrolase family
HMLCPHOH_02216 2.2e-254 yxeK C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HMLCPHOH_02217 7.3e-94 yxeL K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HMLCPHOH_02218 2.5e-144 yxeM M Belongs to the bacterial solute-binding protein 3 family
HMLCPHOH_02219 5.4e-108 yxeN P COG0765 ABC-type amino acid transport system, permease component
HMLCPHOH_02220 5.4e-133 yxeO 3.6.3.21 P ABC transporter, ATP-binding protein
HMLCPHOH_02221 3.8e-215 yxeP 3.5.1.47 E hydrolase activity
HMLCPHOH_02222 2e-255 yxeQ S MmgE/PrpD family
HMLCPHOH_02223 6.8e-201 eutH E Ethanolamine utilisation protein, EutH
HMLCPHOH_02224 3e-153 yxxB S Domain of Unknown Function (DUF1206)
HMLCPHOH_02225 3.5e-174 deoR K COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain
HMLCPHOH_02226 7e-116 deoC 4.1.2.4 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HMLCPHOH_02227 9.8e-206 nupC F Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HMLCPHOH_02228 4.2e-234 pdp 2.4.2.2, 2.4.2.4 F phosphorylase
HMLCPHOH_02229 3.4e-250 lysP E amino acid
HMLCPHOH_02230 6.8e-181 hutG 3.5.3.11, 3.5.3.8 E Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide
HMLCPHOH_02231 1.2e-238 hutI 3.5.2.7 Q Imidazolone-5-propionate hydrolase
HMLCPHOH_02232 0.0 hutU 4.2.1.49 E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HMLCPHOH_02233 2.3e-284 hutH 4.3.1.3 E Histidine ammonia-lyase
HMLCPHOH_02234 5e-78 hutP K Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization
HMLCPHOH_02235 6.3e-284 yxiA 3.2.1.99 GH43 G Belongs to the glycosyl hydrolase 43 family
HMLCPHOH_02236 2.1e-21 S Domain of unknown function (DUF5082)
HMLCPHOH_02237 3.6e-39 yxiC S Family of unknown function (DUF5344)
HMLCPHOH_02238 0.0 S nuclease activity
HMLCPHOH_02239 2.2e-78 S SMI1 / KNR4 family
HMLCPHOH_02240 3.6e-51
HMLCPHOH_02241 0.0 bglF 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
HMLCPHOH_02242 1.1e-280 bglH 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
HMLCPHOH_02243 1.1e-72 yxiE T Belongs to the universal stress protein A family
HMLCPHOH_02244 2.9e-168 yxxF EG EamA-like transporter family
HMLCPHOH_02245 0.0 wapA M COG3209 Rhs family protein
HMLCPHOH_02246 1.5e-71 yxxG
HMLCPHOH_02247 1.7e-84
HMLCPHOH_02248 6.4e-63
HMLCPHOH_02249 3.7e-75 yxiG
HMLCPHOH_02250 4.9e-46
HMLCPHOH_02251 3.8e-81
HMLCPHOH_02252 1.2e-96 yxiI S Protein of unknown function (DUF2716)
HMLCPHOH_02253 1.6e-48 yxiJ S YxiJ-like protein
HMLCPHOH_02256 7.5e-219 3.2.1.14 GH18 E GDSL-like Lipase/Acylhydrolase
HMLCPHOH_02257 1e-265 dbpA 3.6.4.13 JKL DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes
HMLCPHOH_02258 3e-232 yxiO S COG2270 Permeases of the major facilitator superfamily
HMLCPHOH_02259 6.6e-114
HMLCPHOH_02260 8.3e-151 licT K transcriptional antiterminator
HMLCPHOH_02261 5e-144 exoK GH16 M licheninase activity
HMLCPHOH_02262 6.6e-224 citH C Citrate transporter
HMLCPHOH_02263 0.0 katE 1.11.1.6, 3.5.1.124 P serves to protect cells from the toxic effects of hydrogen peroxide
HMLCPHOH_02264 2.7e-48 yxiS
HMLCPHOH_02265 1.2e-22 T Domain of unknown function (DUF4163)
HMLCPHOH_02266 1.9e-212 nupG F Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HMLCPHOH_02267 2.2e-145 rlmA 2.1.1.187 Q Methyltransferase domain
HMLCPHOH_02268 2.6e-253 yxjC EG COG2610 H gluconate symporter and related permeases
HMLCPHOH_02269 1.4e-130 scoA 2.8.3.5 I COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HMLCPHOH_02270 5.2e-116 scoB 2.8.3.5 I COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit
HMLCPHOH_02271 1.3e-137 IQ Catalyzes the formation of acetoacetate from 3-hydroxybutyrate
HMLCPHOH_02272 1e-220 yxjG 2.1.1.14 E Methionine synthase
HMLCPHOH_02273 5.5e-222 yxjG 2.1.1.14 E Methionine synthase
HMLCPHOH_02274 1e-87 yxjI S LURP-one-related
HMLCPHOH_02277 3.6e-235 pepT 3.4.11.4 E Cleaves the N-terminal amino acid of tripeptides
HMLCPHOH_02278 8.9e-116 K helix_turn_helix, Lux Regulon
HMLCPHOH_02279 1.5e-193 yxjM T Signal transduction histidine kinase
HMLCPHOH_02280 2.4e-78 S Protein of unknown function (DUF1453)
HMLCPHOH_02281 1.9e-166 yxjO K LysR substrate binding domain
HMLCPHOH_02282 1.3e-95 yxkA S Phosphatidylethanolamine-binding protein
HMLCPHOH_02283 4.6e-196 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
HMLCPHOH_02284 4.1e-73 yxkC S Domain of unknown function (DUF4352)
HMLCPHOH_02285 1.9e-147 yxkD S Uncharacterised 5xTM membrane BCR, YitT family COG1284
HMLCPHOH_02286 2.5e-275 aldY 1.2.1.3 C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
HMLCPHOH_02287 4.8e-165 lrp QT PucR C-terminal helix-turn-helix domain
HMLCPHOH_02288 5.9e-205 msmK P Belongs to the ABC transporter superfamily
HMLCPHOH_02289 3e-156 yxkH G Polysaccharide deacetylase
HMLCPHOH_02291 0.0 3.4.24.84 O Peptidase family M48
HMLCPHOH_02292 1.5e-229 cimH C COG3493 Na citrate symporter
HMLCPHOH_02293 1.3e-268 cydA 1.10.3.14 C oxidase, subunit
HMLCPHOH_02294 2.9e-190 cydB 1.10.3.14 C Cytochrome d ubiquinol oxidase, subunit II
HMLCPHOH_02295 0.0 cydD V ATP-binding
HMLCPHOH_02296 0.0 cydD V ATP-binding protein
HMLCPHOH_02297 8e-162 nnrD 4.2.1.136, 5.1.99.6 G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HMLCPHOH_02298 2.3e-254 yxlA F Belongs to the purine-cytosine permease (2.A.39) family
HMLCPHOH_02299 4.7e-91 sigY K Belongs to the sigma-70 factor family. ECF subfamily
HMLCPHOH_02300 3.9e-48 yxlC S Family of unknown function (DUF5345)
HMLCPHOH_02301 1.2e-31
HMLCPHOH_02302 7.6e-28 yxlE S Phospholipase_D-nuclease N-terminal
HMLCPHOH_02303 5.1e-167 yxlF V ABC transporter, ATP-binding protein
HMLCPHOH_02304 1.8e-139 yxlG S COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
HMLCPHOH_02305 5.3e-215 yxlH EGP Major facilitator Superfamily
HMLCPHOH_02306 0.0 katX 1.11.1.6 P serves to protect cells from the toxic effects of hydrogen peroxide
HMLCPHOH_02307 1e-110 mpg 3.2.2.21 L Belongs to the DNA glycosylase MPG family
HMLCPHOH_02308 1.1e-19 yxzF
HMLCPHOH_02309 0.0 licR 2.7.1.202 GKT Mga helix-turn-helix domain
HMLCPHOH_02310 2.3e-50 licB 2.7.1.196, 2.7.1.205 G transporter subunit IIB
HMLCPHOH_02311 7.4e-250 licC G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HMLCPHOH_02312 6.7e-38 licA 2.7.1.196, 2.7.1.205 G phosphotransferase system
HMLCPHOH_02313 1.1e-253 licH 3.2.1.86 GT4 G COG1486 Alpha-galactosidases 6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases
HMLCPHOH_02314 3.1e-206 ilvE 2.6.1.42 E Branched-chain amino acid aminotransferase
HMLCPHOH_02315 6.6e-139 dltE M Belongs to the short-chain dehydrogenases reductases (SDR) family
HMLCPHOH_02316 2.3e-231 dltD M COG3966 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HMLCPHOH_02317 1.5e-36 dltC 6.1.1.13 IQ Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HMLCPHOH_02318 1.2e-232 dltB M membrane protein involved in D-alanine export
HMLCPHOH_02319 7.9e-293 dltA 6.1.1.13 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HMLCPHOH_02320 5.4e-167 menA 2.5.1.74 H Belongs to the MenA family. Type 1 subfamily
HMLCPHOH_02321 5e-116 ywaC 2.7.6.5 S protein conserved in bacteria
HMLCPHOH_02322 1.4e-251 ywaD 3.4.11.10, 3.4.11.6 S PA domain
HMLCPHOH_02323 4.4e-233 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HMLCPHOH_02324 8.1e-88 ywaE K Transcriptional regulator
HMLCPHOH_02325 1.7e-128 ywaF S Integral membrane protein
HMLCPHOH_02326 7e-169 gspA M General stress
HMLCPHOH_02327 4e-153 sacY K transcriptional antiterminator
HMLCPHOH_02328 5.2e-243 scrA 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
HMLCPHOH_02329 1.6e-277 epr 3.4.21.62 O Belongs to the peptidase S8 family
HMLCPHOH_02330 5.8e-247 celB G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HMLCPHOH_02331 1.8e-127 ywbB S Protein of unknown function (DUF2711)
HMLCPHOH_02332 4.4e-67 ywbC 4.4.1.5 E glyoxalase
HMLCPHOH_02333 8.9e-223 ywbD 2.1.1.191 J Methyltransferase
HMLCPHOH_02334 1.2e-28 ywbE S Uncharacterized conserved protein (DUF2196)
HMLCPHOH_02335 1.9e-209 ywbF EGP Major facilitator Superfamily
HMLCPHOH_02336 2.3e-111 ywbG M effector of murein hydrolase
HMLCPHOH_02337 6.5e-58 ywbH S Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein. When a cell is stressed by the addition of antibiotics or by other factors in the environment, CidA possibly oligomerizes within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are also hypothesized to regulate the subsequent cell lysis by either allowing the murein hydrolases access to the cell wall substrate and or regulating their activity by a
HMLCPHOH_02338 4.3e-153 ywbI K Transcriptional regulator
HMLCPHOH_02339 2.8e-143 thiM 2.7.1.50 H Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HMLCPHOH_02340 4.1e-116 thiE 2.5.1.3, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
HMLCPHOH_02341 9e-254 P COG0672 High-affinity Fe2 Pb2 permease
HMLCPHOH_02342 2e-187 ycdO P periplasmic lipoprotein involved in iron transport
HMLCPHOH_02343 2.6e-225 ywbN P Dyp-type peroxidase family protein
HMLCPHOH_02344 1.9e-112 ywbO Q dithiol-disulfide isomerase involved in polyketide biosynthesis
HMLCPHOH_02345 1.4e-268 ywcA S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HMLCPHOH_02346 9.8e-49 ywcB S Protein of unknown function, DUF485
HMLCPHOH_02348 2.2e-122 ywcC K transcriptional regulator
HMLCPHOH_02349 9.5e-60 gtcA S GtrA-like protein
HMLCPHOH_02350 6.2e-229 galK 2.7.1.6 G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HMLCPHOH_02351 3.7e-306 galT 2.7.7.12 G UDP-glucose--hexose-1-phosphate uridylyltransferase
HMLCPHOH_02352 1e-35 ywzA S membrane
HMLCPHOH_02353 2.1e-177 cyoA 1.10.3.10, 1.10.3.12 C Catalyzes quinol oxidation with the concomitant reduction of oxygen to water. Subunit II transfers the electrons from a quinol to the binuclear center of the catalytic subunit I
HMLCPHOH_02354 0.0 qoxB 1.10.3.12, 1.9.3.1 C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HMLCPHOH_02355 1.2e-111 qoxC 1.10.3.12, 1.9.3.1 C quinol oxidase, subunit
HMLCPHOH_02356 2.6e-64 qoxD 1.10.3.12, 1.9.3.1 C quinol oxidase, subunit
HMLCPHOH_02357 6e-39 ywcE S Required for proper spore morphogenesis. Important for spore germination
HMLCPHOH_02358 2.9e-202 rodA D Belongs to the SEDS family
HMLCPHOH_02359 7.2e-138 nfrA 1.5.1.38, 1.5.1.39 C Oxidoreductase
HMLCPHOH_02360 5.1e-187 ywcH C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HMLCPHOH_02361 0.0 vpr O Belongs to the peptidase S8 family
HMLCPHOH_02363 2.4e-150 sacT K transcriptional antiterminator
HMLCPHOH_02364 1e-139 focA P Formate/nitrite transporter
HMLCPHOH_02365 3.9e-254 scrA 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
HMLCPHOH_02366 9.5e-296 scrB 3.2.1.26, 3.2.1.65, 3.2.1.80 GH32 G invertase
HMLCPHOH_02367 2e-28 ywdA
HMLCPHOH_02368 9.3e-147 thiD 2.5.1.3, 2.7.1.35, 2.7.1.49, 2.7.4.7, 4.1.99.17 H Phosphomethylpyrimidine kinase
HMLCPHOH_02369 1.3e-57 pex K Transcriptional regulator PadR-like family
HMLCPHOH_02370 1.4e-113 ywdD
HMLCPHOH_02372 1.1e-152 ywdF GT2,GT4 S Glycosyltransferase like family 2
HMLCPHOH_02373 5e-130 ung 3.2.2.27 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HMLCPHOH_02374 5.9e-263 ywdH 1.2.1.3 C Belongs to the aldehyde dehydrogenase family
HMLCPHOH_02375 7.7e-49 ywdI S Family of unknown function (DUF5327)
HMLCPHOH_02376 1.3e-238 ywdJ F Xanthine uracil
HMLCPHOH_02377 4.3e-59 ywdK S small membrane protein
HMLCPHOH_02378 4.8e-75 gerQ S Essential for the localization of CwlJ in the spore coat and for spore germination triggered by calcium and dipicolinic acid (DPA). Its assembly into the spore coat is dependent on the coat morphogenetic proteins CotE and SpoIVA
HMLCPHOH_02379 2.8e-145 spsA M Spore Coat
HMLCPHOH_02380 1.5e-269 spsB M Capsule polysaccharide biosynthesis protein
HMLCPHOH_02381 1.6e-224 spsC E Belongs to the DegT DnrJ EryC1 family
HMLCPHOH_02382 4e-164 spsD 2.3.1.210 K Spore Coat
HMLCPHOH_02383 3.2e-214 spsE 2.5.1.56 M acid synthase
HMLCPHOH_02384 9.7e-132 spsF M Spore Coat
HMLCPHOH_02385 1.7e-190 spsG M Spore Coat
HMLCPHOH_02386 1.9e-138 spsI 2.7.7.24 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HMLCPHOH_02387 1e-181 rfbB 4.2.1.46 M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
HMLCPHOH_02388 5.3e-161 spsK 1.1.1.133 M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
HMLCPHOH_02389 3.5e-87 spsL 5.1.3.13 M Spore Coat
HMLCPHOH_02390 1.8e-78
HMLCPHOH_02391 7.5e-244 rocG 1.4.1.2, 1.4.1.3 E Belongs to the Glu Leu Phe Val dehydrogenases family
HMLCPHOH_02392 1.4e-297 putA 1.2.1.88, 1.5.5.2 C Belongs to the aldehyde dehydrogenase family. RocA subfamily
HMLCPHOH_02393 0.0 rocB E arginine degradation protein
HMLCPHOH_02394 4e-262 lysP E amino acid
HMLCPHOH_02395 4.6e-206 ywfA EGP Major facilitator Superfamily
HMLCPHOH_02396 8.6e-113 pheA 1.1.1.3, 1.3.1.12, 4.1.1.100, 4.2.1.51, 5.4.99.5 E Part of the bacABCDEF operon responsible for the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase. BacA is an unusual prephenate decarboxylase that avoids the typical aromatization of the cyclohexadienol ring of prephenate. BacA catalyzes the protonation of prephenate (1-carboxy-4-hydroxy-alpha-oxo-2,5-cyclohexadiene-1- propanoic acid) at C6 position, followed by a decarboxylation to produce the endocyclic-delta(4),delta(8)-7R-dihydro- hydroxyphenylpyruvate (en-H2HPP). En-H2HPP is able to undergo a slow nonenzymatic isomerization to produce the exocyclic- delta(3),delta(5)-dihydro-hydroxyphenylpyruvate (ex-H2HPP). BacA isomerizes only the pro-R double bond in prephenate
HMLCPHOH_02397 1.3e-136 bacB 5.3.3.19, 5.4.99.5 S Part of the bacABCDEF operon responsible for the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase. BacB catalyzes the allylic isomerization of the
HMLCPHOH_02398 1.3e-139 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HMLCPHOH_02399 3.6e-271 purD 6.3.2.49, 6.3.4.13 F Part of the bacABCDEFG operon responsible for the biosynthesis of bacilysin, an irreversible inactivator of the glutaminase domain of glucosamine synthetase. Catalyzes the formation of alpha-dipeptides from various L-amino acids in the presence of ATP. In vivo catalyzes the ligation of L-alanine and L-anticapsin (epoxycyclohexanonyl-Ala) to produce the final bacilysin antibiotic (L-Ala-L-4S-cyclohexenonyl-Ala dipeptide)
HMLCPHOH_02400 2.9e-210 bacE EGP Major facilitator Superfamily
HMLCPHOH_02401 2.7e-235 ywfG 2.6.1.83 E Aminotransferase class I and II
HMLCPHOH_02402 4e-139 IQ Enoyl-(Acyl carrier protein) reductase
HMLCPHOH_02403 1.1e-146 ywfI C May function as heme-dependent peroxidase
HMLCPHOH_02404 6.6e-176 pta 2.3.1.19, 2.3.1.8, 3.6.3.21 C In Salmonella this enzyme is required for ethanolamine catabolism
HMLCPHOH_02405 9.2e-164 cysL K Transcriptional regulator
HMLCPHOH_02406 6.6e-156 lipL 2.3.1.200, 2.3.1.204 H Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes
HMLCPHOH_02407 5.2e-159 ywfM EG EamA-like transporter family
HMLCPHOH_02408 1.6e-111 rsfA_1
HMLCPHOH_02409 3.1e-36 ywzC S Belongs to the UPF0741 family
HMLCPHOH_02410 1.8e-256 ywfO S COG1078 HD superfamily phosphohydrolases
HMLCPHOH_02411 5.4e-89 ywgA 2.1.1.72, 3.1.21.3
HMLCPHOH_02412 2.8e-79 yffB K Transcriptional regulator
HMLCPHOH_02413 2.6e-242 mmr U Major Facilitator Superfamily
HMLCPHOH_02415 0.0 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HMLCPHOH_02416 3.3e-71 ywhA K Transcriptional regulator
HMLCPHOH_02417 2.7e-25 dmpI 5.3.2.6 G 4-oxalocrotonate tautomerase
HMLCPHOH_02418 5.1e-119 ywhC S Peptidase family M50
HMLCPHOH_02419 5.2e-95 ywhD S YwhD family
HMLCPHOH_02420 0.0 pbpG 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
HMLCPHOH_02421 1.4e-158 speE 2.5.1.16 E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HMLCPHOH_02422 9.2e-169 speB 3.5.3.11 E Belongs to the arginase family
HMLCPHOH_02423 1e-84 ywhH S Aminoacyl-tRNA editing domain
HMLCPHOH_02425 2.3e-79 S aspartate phosphatase
HMLCPHOH_02426 2.5e-205 ywhK CO amine dehydrogenase activity
HMLCPHOH_02427 2.9e-249 ywhL CO amine dehydrogenase activity
HMLCPHOH_02429 1.2e-249 L Peptidase, M16
HMLCPHOH_02430 2.7e-219 2.7.1.26, 2.7.7.2 L Peptidase, M16
HMLCPHOH_02431 3.1e-237 mgtA 3.6.3.2 P ATPase, P-type transporting, HAD superfamily, subfamily IC
HMLCPHOH_02432 3.3e-132 cbiO V ABC transporter
HMLCPHOH_02434 2.6e-271 C Fe-S oxidoreductases
HMLCPHOH_02435 1e-07 S Bacteriocin subtilosin A
HMLCPHOH_02436 4.7e-73 ywiB S protein conserved in bacteria
HMLCPHOH_02437 0.0 argS 6.1.1.19 J Arginyl-tRNA synthetase
HMLCPHOH_02438 9.8e-214 narK P COG2223 Nitrate nitrite transporter
HMLCPHOH_02439 5.3e-130 fnr K helix_turn_helix, cAMP Regulatory protein
HMLCPHOH_02440 1.7e-139 ywiC S YwiC-like protein
HMLCPHOH_02441 7e-86 arfM T cyclic nucleotide binding
HMLCPHOH_02442 0.0 narG 1.7.5.1 C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HMLCPHOH_02443 1.9e-296 narH 1.7.5.1 C Nitrate reductase, beta
HMLCPHOH_02444 3.1e-93 narJ 1.7.5.1 C nitrate reductase
HMLCPHOH_02445 1.8e-124 narI 1.7.5.1 C nitrate reductase, gamma
HMLCPHOH_02446 6.4e-287 ywiE I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HMLCPHOH_02447 0.0 ywjA V ABC transporter
HMLCPHOH_02448 4.8e-96 ywjB H RibD C-terminal domain
HMLCPHOH_02449 2.7e-42 ywjC
HMLCPHOH_02450 6.6e-184 uvsE L Component in a DNA repair pathway. Removal of UV-light damaged nucleotides. Recognizes pyrimidine dimers and cleave a phosphodiester bond immediately 5' to the lesion
HMLCPHOH_02451 2.3e-223 clsB I Belongs to the phospholipase D family. Cardiolipin synthase subfamily
HMLCPHOH_02452 0.0 fadF C COG0247 Fe-S oxidoreductase
HMLCPHOH_02453 2.6e-211 acdA 1.3.8.1, 1.3.8.7 I acyl-CoA dehydrogenase
HMLCPHOH_02454 1.5e-49 rpoE K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
HMLCPHOH_02455 0.0 pyrG 6.3.4.2 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
HMLCPHOH_02456 2.4e-92 ywjG S Domain of unknown function (DUF2529)
HMLCPHOH_02457 1.1e-62 spo0F T COG0784 FOG CheY-like receiver
HMLCPHOH_02458 7.2e-158 fbaA 4.1.2.13, 4.1.2.29 G Aldolase
HMLCPHOH_02459 1.5e-112 tal 2.2.1.2 G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HMLCPHOH_02460 8.6e-240 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HMLCPHOH_02461 1.9e-175 glpX 3.1.3.11, 3.1.3.37 G fructose-1,6-bisphosphatase
HMLCPHOH_02462 2.8e-238 rho K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HMLCPHOH_02463 1.1e-32 rpmE J Binds the 23S rRNA
HMLCPHOH_02464 2.4e-104 tdk 2.7.1.21 F thymidine kinase
HMLCPHOH_02465 0.0 sfcA 1.1.1.38 C malic enzyme
HMLCPHOH_02466 8.6e-160 ywkB S Membrane transport protein
HMLCPHOH_02467 1.7e-91 racA K Required for the formation of axial filaments and for anchoring the origin regions at the cell poles in sporulating cells, thus ensuring proper chromosome segregation in the prespore. Binds in a dispersed manner throughout the chromosome but preferentially to sites clustered in the origin portion of the chromosome, causing condensation of the chromosome and its remodeling into an elongated, anchored structure
HMLCPHOH_02468 8.2e-69 yaeR E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HMLCPHOH_02469 9.5e-192 prfA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HMLCPHOH_02470 2.3e-159 prmC 2.1.1.297 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
HMLCPHOH_02472 3.4e-56 ywlA S Uncharacterised protein family (UPF0715)
HMLCPHOH_02473 6.1e-112 spoIIR S stage II sporulation protein R
HMLCPHOH_02474 1.2e-76 ywlB 1.20.4.1, 2.3.1.1 E Belongs to the acetyltransferase family. ArgA subfamily
HMLCPHOH_02475 1.2e-196 ywlC 2.7.7.87, 3.1.3.48 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
HMLCPHOH_02476 1.7e-91 mntP P Probably functions as a manganese efflux pump
HMLCPHOH_02477 1.7e-78 ywlE 3.1.3.48, 3.9.1.2, 5.3.1.6 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HMLCPHOH_02478 1.7e-81 rpiB 5.3.1.6 G Ribose 5-phosphate isomerase
HMLCPHOH_02479 7.2e-95 ywlG S Belongs to the UPF0340 family
HMLCPHOH_02480 2.1e-238 glyA 2.1.2.1 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HMLCPHOH_02481 4.7e-114 upp 2.4.2.9 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HMLCPHOH_02482 2.5e-62 atpI S ATP synthase
HMLCPHOH_02483 4.6e-129 atpB C it plays a direct role in the translocation of protons across the membrane
HMLCPHOH_02484 1.6e-26 atpE C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HMLCPHOH_02485 3.8e-45 atpF C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HMLCPHOH_02486 1.1e-90 atpH C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HMLCPHOH_02487 6.9e-281 atpA 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HMLCPHOH_02488 1.1e-150 atpG C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HMLCPHOH_02489 1.2e-266 atpD 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HMLCPHOH_02490 5.9e-54 atpC C Produces ATP from ADP in the presence of a proton gradient across the membrane
HMLCPHOH_02491 4.3e-88 ywmA
HMLCPHOH_02492 1.3e-32 ywzB S membrane
HMLCPHOH_02493 1.6e-134 ywmB S TATA-box binding
HMLCPHOH_02494 1.2e-241 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HMLCPHOH_02495 2e-178 spoIID D Stage II sporulation protein D
HMLCPHOH_02496 1.7e-122 ywmC S protein containing a von Willebrand factor type A (vWA) domain
HMLCPHOH_02497 7.2e-121 ywmD S protein containing a von Willebrand factor type A (vWA) domain
HMLCPHOH_02499 2.6e-146 fdhD C Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HMLCPHOH_02500 7e-192 moaA 4.1.99.22, 4.6.1.17 H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HMLCPHOH_02501 1.3e-103 S response regulator aspartate phosphatase
HMLCPHOH_02502 3e-84 ywmF S Peptidase M50
HMLCPHOH_02503 3.8e-11 csbD K CsbD-like
HMLCPHOH_02505 6.3e-51 ureA 3.5.1.5 E Belongs to the urease gamma subunit family
HMLCPHOH_02506 5.9e-64 ureB 3.5.1.5 E Belongs to the urease beta subunit family
HMLCPHOH_02507 0.0 ureC 3.5.1.5 E Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family
HMLCPHOH_02508 1.7e-64 ywnA K Transcriptional regulator
HMLCPHOH_02509 1.6e-114 ywnB S NAD(P)H-binding
HMLCPHOH_02510 2.6e-59 ywnC S Family of unknown function (DUF5362)
HMLCPHOH_02511 4.1e-144 mta K transcriptional
HMLCPHOH_02512 1.2e-277 cls I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HMLCPHOH_02513 2.2e-70 ywnF S Family of unknown function (DUF5392)
HMLCPHOH_02514 2.7e-14 ywnC S Family of unknown function (DUF5362)
HMLCPHOH_02515 6.4e-90 ywnH 2.3.1.183 M COG1247 Sortase and related acyltransferases
HMLCPHOH_02516 5.5e-126 spoIIQ M COG0739 Membrane proteins related to metalloendopeptidases
HMLCPHOH_02517 3.5e-73 ywnJ S VanZ like family
HMLCPHOH_02518 3.4e-103 bcrC 3.6.1.27 I COG0671 Membrane-associated phospholipid phosphatase
HMLCPHOH_02519 1.6e-58 nrgB K Belongs to the P(II) protein family
HMLCPHOH_02520 2.5e-225 amt P Ammonium transporter
HMLCPHOH_02521 2.2e-76
HMLCPHOH_02522 4e-104 phzA Q Isochorismatase family
HMLCPHOH_02523 4.4e-242 ywoD EGP Major facilitator superfamily
HMLCPHOH_02524 3e-281 ybbW FH COG1953 Cytosine uracil thiamine allantoin permeases
HMLCPHOH_02525 1.2e-231 ywoF P Right handed beta helix region
HMLCPHOH_02526 2.7e-211 ywoG EGP Major facilitator Superfamily
HMLCPHOH_02527 2.1e-70 ywoH K COG1846 Transcriptional regulators
HMLCPHOH_02528 3e-44 spoIIID K Stage III sporulation protein D
HMLCPHOH_02529 3.5e-180 mbl D Rod shape-determining protein
HMLCPHOH_02530 6.9e-126 flhO N flagellar basal body
HMLCPHOH_02531 1.5e-141 flhP N flagellar basal body
HMLCPHOH_02532 2.1e-199 S aspartate phosphatase
HMLCPHOH_02533 4.6e-82 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
HMLCPHOH_02534 1.5e-54 mscL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
HMLCPHOH_02535 1.9e-153 ywpD T Histidine kinase
HMLCPHOH_02536 8e-51 srtA 3.4.22.70 M Sortase family
HMLCPHOH_02537 1.1e-66 ywpF S YwpF-like protein
HMLCPHOH_02538 1.3e-66 ywpG
HMLCPHOH_02539 9.8e-58 ssbB L Single-stranded DNA-binding protein
HMLCPHOH_02540 8.8e-139 glcR K COG1349 Transcriptional regulators of sugar metabolism
HMLCPHOH_02541 3.6e-157 ywpJ 3.1.3.104 S hydrolases of the HAD superfamily
HMLCPHOH_02542 0.0 ywqA L COG0553 Superfamily II DNA RNA helicases, SNF2 family
HMLCPHOH_02543 3.8e-309 ywqB S SWIM zinc finger
HMLCPHOH_02544 1.2e-17
HMLCPHOH_02545 2e-116 ywqC M biosynthesis protein
HMLCPHOH_02546 1.1e-119 ywqD 2.7.10.1 D COG0489 ATPases involved in chromosome partitioning
HMLCPHOH_02547 1.4e-141 ywqE 3.1.3.48 GM COG4464 Capsular polysaccharide biosynthesis protein
HMLCPHOH_02548 3e-248 ugd 1.1.1.22 M Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HMLCPHOH_02549 3.4e-154 ywqG S Domain of unknown function (DUF1963)
HMLCPHOH_02550 3.3e-15 S Domain of unknown function (DUF5082)
HMLCPHOH_02551 1.3e-38 ywqI S Family of unknown function (DUF5344)
HMLCPHOH_02552 0.0 ywqJ L nucleic acid phosphodiester bond hydrolysis
HMLCPHOH_02553 1.7e-52 S MORN repeat variant
HMLCPHOH_02554 4.5e-137 nfi 3.1.21.7 L DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA
HMLCPHOH_02555 2.9e-162 K Transcriptional regulator
HMLCPHOH_02556 2.7e-102 ywqN S NAD(P)H-dependent
HMLCPHOH_02558 6.9e-90 ywrA P COG2059 Chromate transport protein ChrA
HMLCPHOH_02559 2.4e-104 ywrB P Chromate transporter
HMLCPHOH_02560 2.1e-82 ywrC K Transcriptional regulator
HMLCPHOH_02561 9.6e-310 ggt 2.3.2.2, 3.4.19.13 E gamma-glutamyltransferase
HMLCPHOH_02562 2.9e-54 S Domain of unknown function (DUF4181)
HMLCPHOH_02563 8.1e-111 ywrF S COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HMLCPHOH_02564 3.7e-12
HMLCPHOH_02565 1.2e-210 cotH M Spore Coat
HMLCPHOH_02566 7.6e-131 cotB
HMLCPHOH_02567 7.5e-126 ywrJ
HMLCPHOH_02568 1.9e-220 ywrK P Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HMLCPHOH_02569 1.1e-169 alsR K LysR substrate binding domain
HMLCPHOH_02570 0.0 alsS 2.2.1.6 EH Belongs to the TPP enzyme family
HMLCPHOH_02571 1.3e-145 budA 4.1.1.5 H Alpha-acetolactate decarboxylase
HMLCPHOH_02572 1.5e-97 ywrO S NADPH-quinone reductase (modulator of drug activity B)
HMLCPHOH_02573 3.6e-48 ywsA S Protein of unknown function (DUF3892)
HMLCPHOH_02574 4.6e-94 batE T Sh3 type 3 domain protein
HMLCPHOH_02575 4.4e-161 rbsB G COG1879 ABC-type sugar transport system, periplasmic component
HMLCPHOH_02576 1.4e-154 rbsC G Belongs to the binding-protein-dependent transport system permease family
HMLCPHOH_02577 2.3e-276 rbsA 3.6.3.17 G Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system
HMLCPHOH_02578 2.8e-64 rbsD 5.4.99.62 G Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose
HMLCPHOH_02579 2.9e-162 rbsK 2.7.1.15, 2.7.1.4 H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HMLCPHOH_02580 1.9e-178 rbsR K transcriptional
HMLCPHOH_02581 6.1e-224 murD 6.3.2.9 M COG0769 UDP-N-acetylmuramyl tripeptide synthase
HMLCPHOH_02582 8.6e-70 pgsC S biosynthesis protein
HMLCPHOH_02583 1.7e-218 capA M enzyme of poly-gamma-glutamate biosynthesis (capsule formation)
HMLCPHOH_02584 3.6e-21 ywtC
HMLCPHOH_02585 5.4e-240 pgdS CBM50 M COG0791 Cell wall-associated hydrolases (invasion-associated proteins)
HMLCPHOH_02586 7e-161 ywtE 3.1.3.104 S hydrolases of the HAD superfamily
HMLCPHOH_02587 8.4e-171 ywtF K Transcriptional regulator
HMLCPHOH_02588 1.9e-248 ywtG EGP Major facilitator Superfamily
HMLCPHOH_02589 7.6e-216 gerAC S Spore germination protein
HMLCPHOH_02590 7.5e-200 gerBB E Spore germination protein
HMLCPHOH_02591 3.5e-266 gerBA EG Spore germination protein
HMLCPHOH_02592 7.1e-191 pmi 5.3.1.8 G mannose-6-phosphate isomerase
HMLCPHOH_02593 7.2e-217 atl 3.2.1.96, 3.5.1.28 GH73 G Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
HMLCPHOH_02594 1.2e-260
HMLCPHOH_02595 5e-215 tagB 2.7.8.14, 2.7.8.44, 2.7.8.47 M glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HMLCPHOH_02596 1.8e-144 tagA 2.4.1.187 GT26 M Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid
HMLCPHOH_02597 5.7e-70 tagD 2.7.7.15, 2.7.7.39 IM Cytidylyltransferase
HMLCPHOH_02598 0.0 tagE 2.4.1.52 GT4 M Glycosyl transferase 1 domain A
HMLCPHOH_02599 0.0 tagF 2.7.8.12 M glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HMLCPHOH_02600 1.1e-150 tagG GM Transport permease protein
HMLCPHOH_02601 1.8e-279 tagH 3.6.3.38, 3.6.3.40 GM Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system
HMLCPHOH_02602 1.6e-100 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
HMLCPHOH_02604 8.1e-257 ggaA M Glycosyltransferase like family 2
HMLCPHOH_02605 0.0 ggaB GT2 M CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
HMLCPHOH_02606 9e-164 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
HMLCPHOH_02607 8.2e-218 mnaA 5.1.3.14 M Belongs to the UDP-N-acetylglucosamine 2-epimerase family
HMLCPHOH_02608 6.1e-163 lytR K May catalyze the final step in cell wall teichoic acid biosynthesis, the transfer of the anionic cell wall polymers (APs) from their lipid-linked precursor to the cell wall peptidoglycan (PG)
HMLCPHOH_02609 6e-38
HMLCPHOH_02610 0.0 lytB 3.5.1.28 D Stage II sporulation protein
HMLCPHOH_02611 3e-268 lytC 3.5.1.28 M n-acetylmuramoyl-L-alanine amidase
HMLCPHOH_02612 4.6e-112 tuaA M COG2148 Sugar transferases involved in lipopolysaccharide synthesis
HMLCPHOH_02613 3.3e-248 wzxC S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
HMLCPHOH_02614 7.4e-222 tuaC 2.4.1.21, 3.2.1.1 GH13,GT4,GT5 GM Teichuronic acid
HMLCPHOH_02615 2.4e-259 tuaD 1.1.1.22 M Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HMLCPHOH_02616 1.7e-263 tuaE M Teichuronic acid biosynthesis protein
HMLCPHOH_02617 6e-115 tuaF M protein involved in exopolysaccharide biosynthesis
HMLCPHOH_02618 2.1e-145 tuaG GT2 M Glycosyltransferase like family 2
HMLCPHOH_02619 4.4e-238 tuaH M Teichuronic acid biosynthesis glycosyltransferase tuaH
HMLCPHOH_02620 2.6e-181 tagO 2.7.8.33, 2.7.8.35 M COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase UDP-N-acetylglucosamine-1-phosphate transferase
HMLCPHOH_02621 6e-163 yvhJ K Transcriptional regulator
HMLCPHOH_02622 2e-120 yvyE 3.4.13.9 S Domain of unknown function (DUF1949)
HMLCPHOH_02623 5.1e-183 degS 2.7.13.3 T Member of the two-component regulatory system DegS DegU, which plays an important role in the transition growth phase
HMLCPHOH_02624 2e-126 degU KT COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HMLCPHOH_02625 7.3e-155 degV S protein conserved in bacteria
HMLCPHOH_02626 5.6e-269 comFA L COG4098 Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HMLCPHOH_02627 5.7e-46 comFB S Late competence development protein ComFB
HMLCPHOH_02628 2.7e-129 comFC S Phosphoribosyl transferase domain
HMLCPHOH_02629 7e-74 yvyF S flagellar protein
HMLCPHOH_02630 4.2e-40 flgM KNU Negative regulator of flagellin synthesis
HMLCPHOH_02631 2.4e-78 flgN NOU FlgN protein
HMLCPHOH_02632 1.2e-264 flgK N flagellar hook-associated protein
HMLCPHOH_02633 1.1e-156 flgL N Belongs to the bacterial flagellin family
HMLCPHOH_02634 2.6e-50 yviE
HMLCPHOH_02635 2.7e-73 fliW S Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HMLCPHOH_02636 2e-30 csrA T Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HMLCPHOH_02637 1.9e-156 fliC N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HMLCPHOH_02638 6.1e-57 flaG N flagellar protein FlaG
HMLCPHOH_02639 1.3e-266 fliD N morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HMLCPHOH_02640 2.9e-69 fliS N flagellar protein FliS
HMLCPHOH_02641 1.9e-08 fliT S bacterial-type flagellum organization
HMLCPHOH_02642 2.8e-66
HMLCPHOH_02643 2.2e-102 hpf J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HMLCPHOH_02644 0.0 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
HMLCPHOH_02645 6.1e-185 prfB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HMLCPHOH_02646 5.5e-142 yvjA S Uncharacterized protein conserved in bacteria (DUF2179)
HMLCPHOH_02647 5.3e-56 cccB C COG2010 Cytochrome c, mono- and diheme variants
HMLCPHOH_02648 1.6e-123 ftsE D cell division ATP-binding protein FtsE
HMLCPHOH_02649 1.6e-155 ftsX D Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation
HMLCPHOH_02650 6.9e-270 ctpB 3.4.21.102 M Belongs to the peptidase S41A family
HMLCPHOH_02651 5.3e-56 swrA S Swarming motility protein
HMLCPHOH_02652 4.9e-221 minJ O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HMLCPHOH_02653 7.9e-228 yvkA EGP Major facilitator Superfamily
HMLCPHOH_02654 7e-101 yvkB K Transcriptional regulator
HMLCPHOH_02655 0.0 yvkC 2.7.9.2 GT Phosphotransferase
HMLCPHOH_02656 1.2e-30 csbA S protein conserved in bacteria
HMLCPHOH_02657 0.0 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
HMLCPHOH_02658 0.0 uvrA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
HMLCPHOH_02659 2.9e-79 fliC N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HMLCPHOH_02660 6.7e-34 yvkN
HMLCPHOH_02661 8e-49 yvlA
HMLCPHOH_02662 3.4e-168 yvlB S Putative adhesin
HMLCPHOH_02663 2.6e-26 pspB KT PspC domain
HMLCPHOH_02664 1.2e-50 yvlD S Membrane
HMLCPHOH_02665 2.7e-203 yvmA EGP Major facilitator Superfamily
HMLCPHOH_02666 3e-87 yvmB K helix_turn_helix multiple antibiotic resistance protein
HMLCPHOH_02667 1.6e-137 yvmC 2.3.2.22 S Involved in the biosynthesis of pulcherrimin, a red extracellular pigment. It uses activated amino acids in the form of aminoacyl-tRNAs (aa-tRNAs) as substrates to catalyze the ATP- independent formation of cyclodipeptides which are intermediates in diketopiperazine (DKP) biosynthetic pathways. Catalyzes the formation of cyclo(L-Leu-L-Leu) (cLL) from L-leucyl-tRNA(Leu). Can also incorporate various nonpolar residues, such as L- phenylalanine, L-leucine and methionine, into cyclodipeptides
HMLCPHOH_02668 8.2e-232 cypX 1.14.15.13 C Cytochrome P450
HMLCPHOH_02669 8.5e-84 adcR K helix_turn_helix multiple antibiotic resistance protein
HMLCPHOH_02670 0.0 yvnB 3.1.4.53 Q Calcineurin-like phosphoesterase
HMLCPHOH_02671 3.6e-134 yvoA K transcriptional
HMLCPHOH_02672 8.9e-133 nagB 3.1.1.31, 3.5.99.6 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
HMLCPHOH_02673 6.8e-223 nagA 3.5.1.25 G Belongs to the metallo-dependent hydrolases superfamily. NagA family
HMLCPHOH_02674 1.7e-168 hprK F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HMLCPHOH_02675 4.9e-148 lgt 2.1.1.199 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HMLCPHOH_02676 1.5e-164 yvoD P COG0370 Fe2 transport system protein B
HMLCPHOH_02677 1.3e-119 ppaX 3.1.3.18, 3.6.1.1 S Hydrolyzes pyrophosphate formed during P-Ser-HPr dephosphorylation by HPrK P. Might play a role in controlling the intracellular pyrophosphate pool
HMLCPHOH_02678 3e-82 yvoF S COG0110 Acetyltransferase (isoleucine patch superfamily)
HMLCPHOH_02679 5.5e-121 hrpW 4.2.2.10, 4.2.2.2 G Pectate lyase
HMLCPHOH_02680 4.5e-140 yvpB NU protein conserved in bacteria
HMLCPHOH_02681 4.8e-221 hisZ 2.4.2.17, 6.1.1.21 E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HMLCPHOH_02682 1.5e-115 hisG 2.4.2.17 E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
HMLCPHOH_02683 6.6e-232 hisD 1.1.1.23, 1.1.1.308 E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HMLCPHOH_02684 2.1e-108 hisB 1.1.1.23, 2.6.1.9, 3.1.3.15, 4.2.1.19 E imidazoleglycerol-phosphate dehydratase
HMLCPHOH_02685 1.7e-116 hisH E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HMLCPHOH_02686 3.1e-133 hisA 5.3.1.16 E 1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HMLCPHOH_02687 2.8e-137 hisF E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
HMLCPHOH_02688 8e-114 hisE 3.5.4.19, 3.6.1.31, 5.3.1.16 E belongs to the PRA-CH family
HMLCPHOH_02689 4.6e-121
HMLCPHOH_02690 0.0
HMLCPHOH_02692 0.0 msbA2 3.6.3.44 V ABC transporter
HMLCPHOH_02693 2.4e-278 S COG0457 FOG TPR repeat
HMLCPHOH_02694 1.4e-102 usp CBM50 M protein conserved in bacteria
HMLCPHOH_02695 1.4e-175 trxB 1.8.1.9 C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
HMLCPHOH_02696 1.8e-89 yvcI 3.6.1.55 F COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
HMLCPHOH_02697 5.7e-166 rapZ S Displays ATPase and GTPase activities
HMLCPHOH_02698 7.3e-178 ybhK S Required for morphogenesis under gluconeogenic growth conditions
HMLCPHOH_02699 1.4e-170 whiA K May be required for sporulation
HMLCPHOH_02700 1.6e-36 crh G Phosphocarrier protein Chr
HMLCPHOH_02701 8.6e-147 nhoA 2.3.1.118 Q Belongs to the arylamine N-acetyltransferase family
HMLCPHOH_02702 1.8e-33
HMLCPHOH_02703 3.9e-133 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HMLCPHOH_02704 2.3e-198 yvcQ 2.7.13.3 T His Kinase A (phosphoacceptor) domain
HMLCPHOH_02705 5.6e-141 yvcR V ABC transporter, ATP-binding protein
HMLCPHOH_02706 0.0 yxdM V ABC transporter (permease)
HMLCPHOH_02707 1.3e-184 ghrB 1.1.1.215, 1.1.1.26, 1.1.1.43, 1.1.1.79, 1.1.1.81 CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HMLCPHOH_02708 5.7e-106 ytiB 4.2.1.1 P Reversible hydration of carbon dioxide
HMLCPHOH_02709 2.1e-288 sulP P COG0659 Sulfate permease and related transporters (MFS superfamily)
HMLCPHOH_02710 6.8e-53 yvdC S MazG nucleotide pyrophosphohydrolase domain
HMLCPHOH_02711 3.3e-106 yvdD 3.2.2.10 S Belongs to the LOG family
HMLCPHOH_02712 3.6e-174 yvdE K Transcriptional regulator
HMLCPHOH_02713 0.0 nplT 3.2.1.133, 3.2.1.135, 3.2.1.54 GH13 G Alpha amylase, N-terminal ig-like domain
HMLCPHOH_02714 1.3e-235 mdxE G COG2182 Maltose-binding periplasmic proteins domains
HMLCPHOH_02715 5.3e-245 malC P COG1175 ABC-type sugar transport systems, permease components
HMLCPHOH_02716 7.8e-149 malD P transport
HMLCPHOH_02717 1.2e-158 malA S Protein of unknown function (DUF1189)
HMLCPHOH_02718 0.0 yvdK 2.4.1.8 GH65 G Glycoside hydrolase, family 65
HMLCPHOH_02719 0.0 malL 3.2.1.10 GH13 G COG0366 Glycosidases
HMLCPHOH_02720 1.3e-122 pgmB 2.4.1.64, 3.1.3.12, 3.2.1.28, 5.4.2.6 GH37,GH65 S Haloacid dehalogenase-like hydrolase
HMLCPHOH_02721 1.2e-103 clpP 3.4.21.92 OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
HMLCPHOH_02723 1.5e-183 S Patatin-like phospholipase
HMLCPHOH_02724 8.4e-270 ygaK C COG0277 FAD FMN-containing dehydrogenases
HMLCPHOH_02725 2.2e-93 yvdQ S Protein of unknown function (DUF3231)
HMLCPHOH_02726 4.1e-50 sugE P Small Multidrug Resistance protein
HMLCPHOH_02727 6.7e-51 ykkC P Small Multidrug Resistance protein
HMLCPHOH_02728 2.6e-106 yvdT K Transcriptional regulator
HMLCPHOH_02729 1.8e-295 yveA E amino acid
HMLCPHOH_02730 0.0 levB 3.2.1.26, 3.2.1.64, 3.2.1.65, 3.2.1.80 GH32 G Belongs to the glycosyl hydrolase 32 family
HMLCPHOH_02731 1.2e-274 sacB 2.4.1.10 GH68 M levansucrase activity
HMLCPHOH_02732 9.6e-266 pbpE V Beta-lactamase
HMLCPHOH_02733 3.1e-127 racX 5.1.1.13 M Belongs to the aspartate glutamate racemases family
HMLCPHOH_02734 1.3e-48 MA20_18690 S Protein of unknown function (DUF3237)
HMLCPHOH_02735 4.6e-93 padC Q Phenolic acid decarboxylase
HMLCPHOH_02737 4.8e-287 pnbA CE10 I Belongs to the type-B carboxylesterase lipase family
HMLCPHOH_02738 5.7e-77 slr K transcriptional
HMLCPHOH_02739 4e-122 ywqC M biosynthesis protein
HMLCPHOH_02740 1e-114 epsB 2.7.10.2 D COG0489 ATPases involved in chromosome partitioning
HMLCPHOH_02741 0.0 pglF 4.2.1.115, 4.2.1.135, 4.2.1.46 GM Polysaccharide biosynthesis protein
HMLCPHOH_02742 2e-224 epsD GT4 M Glycosyl transferase 4-like
HMLCPHOH_02743 4.1e-158 epsE GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
HMLCPHOH_02744 4e-220 epsF GT4 M Glycosyl transferases group 1
HMLCPHOH_02745 4.8e-207 epsG S EpsG family
HMLCPHOH_02746 3.6e-196 epsH GT2 S Glycosyltransferase like family 2
HMLCPHOH_02747 3.6e-207 epsI GM pyruvyl transferase
HMLCPHOH_02748 1.9e-197 epsJ GT2 S COG0463 Glycosyltransferases involved in cell wall biogenesis
HMLCPHOH_02749 8.9e-260 pglK S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
HMLCPHOH_02750 2.6e-109 epsL M COG2148 Sugar transferases involved in lipopolysaccharide synthesis
HMLCPHOH_02751 2.2e-58 epsM GM COG0110 Acetyltransferase (isoleucine patch superfamily)
HMLCPHOH_02752 1.2e-224 epsN 2.6.1.102 E Belongs to the DegT DnrJ EryC1 family
HMLCPHOH_02753 5.8e-188 yvfF GM Exopolysaccharide biosynthesis protein
HMLCPHOH_02754 1e-31 yvfG S YvfG protein
HMLCPHOH_02755 6.5e-243 rpoN K COG1508 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog
HMLCPHOH_02756 1.4e-309 yvfH C L-lactate permease
HMLCPHOH_02757 1e-112 yvfI K COG2186 Transcriptional regulators
HMLCPHOH_02758 1.8e-184 lacR K Transcriptional regulator
HMLCPHOH_02759 2.9e-232 cycB G COG2182 Maltose-binding periplasmic proteins domains
HMLCPHOH_02760 1.3e-232 malC P COG1175 ABC-type sugar transport systems, permease components
HMLCPHOH_02761 3.2e-150 ganQ P transport
HMLCPHOH_02762 0.0 lacA 3.2.1.23 G beta-galactosidase
HMLCPHOH_02763 2.6e-252 galA 3.2.1.89 G arabinogalactan
HMLCPHOH_02764 1.4e-199 rsbU 3.1.3.3 T response regulator
HMLCPHOH_02765 2.6e-157 rsbQ S Alpha/beta hydrolase family
HMLCPHOH_02766 3e-162 yvfR V COG1131 ABC-type multidrug transport system, ATPase component
HMLCPHOH_02767 6.2e-134 yvfS V COG0842 ABC-type multidrug transport system, permease component
HMLCPHOH_02768 8.9e-201 desK 2.7.13.3 T Histidine kinase
HMLCPHOH_02769 2.6e-106 desR T COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HMLCPHOH_02770 1.5e-137 lutA C Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source
HMLCPHOH_02771 1.2e-274 lutB C Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source. Has probably a role as an electron transporter during oxidation of L-lactate
HMLCPHOH_02772 2.3e-133 lutC S Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source
HMLCPHOH_02773 4.3e-197 yvbX S Glycosyl hydrolase
HMLCPHOH_02774 2.8e-241 yvbW E COG1113 Gamma-aminobutyrate permease and related permeases
HMLCPHOH_02775 8.5e-157 yvbV EG EamA-like transporter family
HMLCPHOH_02776 3.9e-159 yvbU K Transcriptional regulator
HMLCPHOH_02777 1.5e-191 yvbT C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HMLCPHOH_02778 5.5e-203 araR K transcriptional
HMLCPHOH_02779 1.6e-252 araE EGP Major facilitator Superfamily
HMLCPHOH_02780 6.3e-185 cggR K COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain
HMLCPHOH_02781 6.2e-185 gapA 1.2.1.12 G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
HMLCPHOH_02782 1e-218 pgk 2.7.2.3, 5.3.1.1 F Belongs to the phosphoglycerate kinase family
HMLCPHOH_02783 4.3e-138 tpiA 2.7.2.3, 5.3.1.1 G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
HMLCPHOH_02784 1.3e-298 gpmI 5.4.2.12 G Catalyzes the interconversion of 2-phosphoglycerate and
HMLCPHOH_02785 8.4e-243 eno 4.2.1.11 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
HMLCPHOH_02786 7.7e-82 yvbK 3.1.3.25 K acetyltransferase
HMLCPHOH_02787 0.0 tcaA S response to antibiotic
HMLCPHOH_02788 4.2e-124 exoY M Membrane
HMLCPHOH_02789 8.6e-113 yvbH S YvbH-like oligomerisation region
HMLCPHOH_02790 6.4e-103 yvbG U UPF0056 membrane protein
HMLCPHOH_02791 1.4e-98 yvbF K Belongs to the GbsR family
HMLCPHOH_02792 8.8e-212 opuCA 3.6.3.32 E COG1125 ABC-type proline glycine betaine transport systems, ATPase components
HMLCPHOH_02793 4.5e-112 opuCB P COG1174 ABC-type proline glycine betaine transport systems, permease component
HMLCPHOH_02794 2.5e-172 opuCC M COG1732 Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
HMLCPHOH_02795 8.7e-114 opuCD P COG1174 ABC-type proline glycine betaine transport systems, permease component
HMLCPHOH_02796 4.5e-45 sdpR K transcriptional
HMLCPHOH_02797 3.3e-96 sdpI S Immunity protein that provides protection for the cell against the toxic effects of SDP, its own SdpC-derived killing factor, and that functions as a receptor signal transduction protein as well. Once SDP accumulates in the extracellular milieu, SdpI binds to SDP, causing sequestration of SdpR at the bacterial membrane
HMLCPHOH_02798 4.4e-08
HMLCPHOH_02799 7.6e-172
HMLCPHOH_02800 7.9e-13 S Sporulation delaying protein SdpA
HMLCPHOH_02801 8.7e-61 yvbF K Belongs to the GbsR family
HMLCPHOH_02802 3e-212 opuCA 3.6.3.32 E COG1125 ABC-type proline glycine betaine transport systems, ATPase components
HMLCPHOH_02803 2.5e-110 opuCB P COG1174 ABC-type proline glycine betaine transport systems, permease component
HMLCPHOH_02804 1.1e-172 opuCC M COG1732 Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
HMLCPHOH_02805 8.1e-112 opuCD P COG1174 ABC-type proline glycine betaine transport systems, permease component
HMLCPHOH_02806 4.2e-226 NT chemotaxis protein
HMLCPHOH_02807 2.2e-54 yodB K transcriptional
HMLCPHOH_02808 8e-70 yvaO K Cro/C1-type HTH DNA-binding domain
HMLCPHOH_02809 4e-69 K transcriptional
HMLCPHOH_02810 7.5e-36 yvzC K Transcriptional
HMLCPHOH_02811 3.7e-153 yvaM S Serine aminopeptidase, S33
HMLCPHOH_02812 2.4e-23 secG U Preprotein translocase subunit SecG
HMLCPHOH_02813 5.6e-143 est 3.1.1.1 S Carboxylesterase
HMLCPHOH_02814 0.0 rnr K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
HMLCPHOH_02815 1.6e-82 smpB O Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HMLCPHOH_02817 9.1e-131 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
HMLCPHOH_02818 4.1e-101 K Bacterial regulatory proteins, tetR family
HMLCPHOH_02819 2.8e-55 yvaE P Small Multidrug Resistance protein
HMLCPHOH_02820 5.7e-73 yvaD S Family of unknown function (DUF5360)
HMLCPHOH_02821 0.0 yvaC S Fusaric acid resistance protein-like
HMLCPHOH_02822 2.4e-118 azoR I Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HMLCPHOH_02823 2.1e-199 yvaA 1.1.1.371 S Oxidoreductase
HMLCPHOH_02824 2.2e-48 csoR S transcriptional
HMLCPHOH_02825 1.5e-29 copZ P Copper resistance protein CopZ
HMLCPHOH_02826 0.0 copA 3.6.3.54 P P-type ATPase
HMLCPHOH_02827 0.0 cadA 3.6.3.3, 3.6.3.5 P COG2217 Cation transport ATPase
HMLCPHOH_02828 1.6e-104 bdbD O Thioredoxin
HMLCPHOH_02829 2.2e-72 bdbC O Required for disulfide bond formation in some proteins
HMLCPHOH_02830 4.1e-107 yvgT S membrane
HMLCPHOH_02831 0.0 helD 3.6.4.12 L DNA helicase
HMLCPHOH_02832 0.0 cysJ 1.8.1.2 P Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HMLCPHOH_02833 0.0 cysI 1.7.7.1, 1.8.1.2, 1.8.7.1 P Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate
HMLCPHOH_02834 0.0 yjcE P COG0025 NhaP-type Na H and K H antiporters
HMLCPHOH_02835 5.4e-86 yvgO
HMLCPHOH_02836 9.1e-158 yvgN S reductase
HMLCPHOH_02837 4.7e-120 modB P COG4149 ABC-type molybdate transport system, permease component
HMLCPHOH_02838 5.8e-138 modA P COG0725 ABC-type molybdate transport system, periplasmic component
HMLCPHOH_02839 8e-171 yvgK P COG1910 Periplasmic molybdate-binding protein domain
HMLCPHOH_02840 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
HMLCPHOH_02841 1e-84 yvsG S LexA-binding, inner membrane-associated putative hydrolase
HMLCPHOH_02842 6.5e-16 S Small spore protein J (Spore_SspJ)
HMLCPHOH_02843 2.6e-237 yvsH E Arginine ornithine antiporter
HMLCPHOH_02845 2.1e-179 fhuD P ABC transporter
HMLCPHOH_02846 9.3e-184 fhuB P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMLCPHOH_02847 5.3e-176 fhuG P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMLCPHOH_02848 4.4e-149 fhuC 3.6.3.34 HP ABC transporter
HMLCPHOH_02849 4.8e-176 M Efflux transporter rnd family, mfp subunit
HMLCPHOH_02850 7.1e-124 macB V ABC transporter, ATP-binding protein
HMLCPHOH_02851 1.8e-210 yvrN V COG0577 ABC-type antimicrobial peptide transport system, permease component
HMLCPHOH_02852 1.3e-64 yvrL S Regulatory protein YrvL
HMLCPHOH_02853 7.3e-230 oxdC 4.1.1.2 G Oxalate decarboxylase
HMLCPHOH_02854 2.4e-19 S YvrJ protein family
HMLCPHOH_02855 1.8e-96 yvrI K RNA polymerase
HMLCPHOH_02856 3.6e-22
HMLCPHOH_02857 3.2e-131 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HMLCPHOH_02858 0.0 T PhoQ Sensor
HMLCPHOH_02859 1.5e-171 yvrE G SMP-30/Gluconolaconase/LRE-like region
HMLCPHOH_02860 6.2e-140 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
HMLCPHOH_02861 1.8e-170 yvrC P COG0614 ABC-type Fe3 -hydroxamate transport system, periplasmic component
HMLCPHOH_02862 7.7e-186 btuC P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMLCPHOH_02863 2.8e-249 yvrA 3.6.3.34 HP COG1120 ABC-type cobalamin Fe3 -siderophores transport systems, ATPase components
HMLCPHOH_02864 6.5e-102 yvqK 2.5.1.17 S Adenosyltransferase
HMLCPHOH_02865 4.8e-227 yvqJ EGP Major facilitator Superfamily
HMLCPHOH_02866 5.6e-62 liaI S membrane
HMLCPHOH_02867 2.5e-105 liaH KT COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription
HMLCPHOH_02868 9.3e-129 liaG S Putative adhesin
HMLCPHOH_02869 5.6e-127 yvqF S Cell wall-active antibiotics response 4TMS YvqF
HMLCPHOH_02870 5.5e-187 vraS 2.7.13.3 T Histidine kinase
HMLCPHOH_02871 1.3e-108 vraR KT COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HMLCPHOH_02872 6e-189 gerAC S Spore germination B3/ GerAC like, C-terminal
HMLCPHOH_02873 9.1e-198 gerAB E Spore germination protein
HMLCPHOH_02874 3.7e-247 gerAA EG Spore germination protein
HMLCPHOH_02875 2.3e-24 S Protein of unknown function (DUF3970)
HMLCPHOH_02876 2.5e-261 fumC 1.1.1.38, 4.2.1.2 C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
HMLCPHOH_02877 4.3e-158 yuxN K Transcriptional regulator
HMLCPHOH_02878 4.3e-250 cssS 2.7.13.3 T PhoQ Sensor
HMLCPHOH_02879 3.4e-126 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HMLCPHOH_02880 9.6e-237 htrA 3.4.21.107 O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HMLCPHOH_02881 1.2e-79 dps P Ferritin-like domain
HMLCPHOH_02882 4.7e-154 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
HMLCPHOH_02883 3.9e-34 pepF2 E COG1164 Oligoendopeptidase F
HMLCPHOH_02884 6.3e-258 pepF2 E COG1164 Oligoendopeptidase F
HMLCPHOH_02885 5.6e-66 S YusW-like protein
HMLCPHOH_02886 1e-153 yusV 3.6.3.34 HP ABC transporter
HMLCPHOH_02887 3.8e-47 yusU S Protein of unknown function (DUF2573)
HMLCPHOH_02888 2.7e-160 yusT K LysR substrate binding domain
HMLCPHOH_02889 2.5e-50 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
HMLCPHOH_02890 2.5e-62 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
HMLCPHOH_02891 8.4e-66 yusQ S Tautomerase enzyme
HMLCPHOH_02892 3.8e-293 yusP P Major facilitator superfamily
HMLCPHOH_02893 5.4e-75 yusO K Iron dependent repressor, N-terminal DNA binding domain
HMLCPHOH_02894 3.2e-53 yusN M Coat F domain
HMLCPHOH_02895 5.1e-40
HMLCPHOH_02896 2.2e-165 fadM E Proline dehydrogenase
HMLCPHOH_02897 4.7e-09 S YuzL-like protein
HMLCPHOH_02898 0.0 fadB 1.1.1.35, 4.2.1.17, 5.1.2.3 I 3-hydroxyacyl-CoA dehydrogenase
HMLCPHOH_02899 1.4e-217 fadA 2.3.1.16 I Belongs to the thiolase family
HMLCPHOH_02900 0.0 fadE 1.3.8.1 I acyl-CoA dehydrogenase
HMLCPHOH_02901 2.8e-63 arsC 1.20.4.1 P Belongs to the ArsC family
HMLCPHOH_02902 9.3e-65 gcvH E Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate
HMLCPHOH_02903 1.1e-39 yusG S Protein of unknown function (DUF2553)
HMLCPHOH_02904 3.3e-74 rnmV 3.1.26.8 L COG1658 Small primase-like proteins (Toprim domain)
HMLCPHOH_02905 5.6e-55 traF CO Thioredoxin
HMLCPHOH_02906 2.4e-56 yusD S SCP-2 sterol transfer family
HMLCPHOH_02907 4.8e-185 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HMLCPHOH_02908 1.4e-95 metI P COG2011 ABC-type metal ion transport system, permease component
HMLCPHOH_02909 1.9e-147 metQ P Belongs to the NlpA lipoprotein family
HMLCPHOH_02910 1.1e-62 yurZ 2.3.1.12, 4.1.1.44 S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HMLCPHOH_02911 2.3e-142 sufC O COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component
HMLCPHOH_02912 1.4e-245 sufD O assembly protein SufD
HMLCPHOH_02913 9.4e-236 sufS 2.8.1.7, 4.4.1.16 E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HMLCPHOH_02914 1.4e-77 nifU C COG0822 NifU homolog involved in Fe-S cluster formation
HMLCPHOH_02915 3.5e-271 sufB O FeS cluster assembly
HMLCPHOH_02916 7.6e-67 yurT E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HMLCPHOH_02917 1e-41
HMLCPHOH_02919 1.8e-209 yurR 1.4.5.1 E COG0665 Glycine D-amino acid oxidases (deaminating)
HMLCPHOH_02920 2.8e-66 yurQ 2.7.7.7 L COG0322 Nuclease subunit of the excinuclease complex
HMLCPHOH_02921 1.8e-184 frlB M Catalyzes the conversion of a range of fructosamine 6- phosphates to glucose 6-phosphate and a free amino acid
HMLCPHOH_02922 1.3e-240 yurO G COG1653 ABC-type sugar transport system, periplasmic component
HMLCPHOH_02923 1.4e-156 yurN G Binding-protein-dependent transport system inner membrane component
HMLCPHOH_02924 7.3e-169 yurM P COG0395 ABC-type sugar transport system, permease component
HMLCPHOH_02925 1.5e-163 yurL 2.7.1.218 G pfkB family carbohydrate kinase
HMLCPHOH_02926 1.1e-135 yurK K UTRA
HMLCPHOH_02927 1.2e-205 msmX P Belongs to the ABC transporter superfamily
HMLCPHOH_02928 2.4e-169 bsn L Ribonuclease
HMLCPHOH_02929 1.6e-238 pucF 3.5.1.6, 3.5.1.87, 3.5.3.9 E COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases
HMLCPHOH_02930 1.9e-239 pucG 2.6.1.112, 2.6.1.44, 2.6.1.45, 2.6.1.51 E COG0075 Serine-pyruvate aminotransferase archaeal aspartate aminotransferase
HMLCPHOH_02932 1.7e-190 pucA 1.17.1.4 O COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HMLCPHOH_02933 3.6e-111 pucB 1.1.1.328, 1.17.1.4, 2.7.7.76 S MobA-like NTP transferase domain
HMLCPHOH_02934 3.4e-152 ygfM 1.17.1.4, 1.2.5.3 C COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM CutM homologs
HMLCPHOH_02935 0.0 xdhA 1.17.1.4 C COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs
HMLCPHOH_02936 1.8e-95 1.17.1.4, 1.2.5.3, 1.3.99.16 C COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs
HMLCPHOH_02937 2.7e-55 uraH 3.5.2.17, 4.1.1.97 S Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily
HMLCPHOH_02938 7.3e-283 uraD 1.7.3.3, 3.5.1.41, 4.1.1.97 Q Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin
HMLCPHOH_02939 1.3e-222 pbuX F xanthine
HMLCPHOH_02940 2.1e-236 pbuX F Permease family
HMLCPHOH_02941 1.2e-302 pucR QT COG2508 Regulator of polyketide synthase expression
HMLCPHOH_02942 1e-259 allB 3.5.2.5 F Catalyzes the conversion of allantoin (5- ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring
HMLCPHOH_02943 3e-62 yunG
HMLCPHOH_02944 4.3e-171 yunF S Protein of unknown function DUF72
HMLCPHOH_02945 2e-141 yunE S membrane transporter protein
HMLCPHOH_02946 5.8e-266 yunD 3.1.3.5 F Belongs to the 5'-nucleotidase family
HMLCPHOH_02947 4.8e-48 yunC S Domain of unknown function (DUF1805)
HMLCPHOH_02948 8.4e-134 yunB S Sporulation protein YunB (Spo_YunB)
HMLCPHOH_02949 4.5e-196 lytH M Peptidase, M23
HMLCPHOH_02950 1e-167 lipA 2.8.1.8 H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HMLCPHOH_02951 4.9e-111 yutC S Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
HMLCPHOH_02952 9.7e-48 yutD S protein conserved in bacteria
HMLCPHOH_02953 1e-75 yutE S Protein of unknown function DUF86
HMLCPHOH_02954 6.5e-142 nagD 2.7.1.25, 3.1.3.41 G Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
HMLCPHOH_02955 2.5e-77 pgpA 3.1.3.27 I COG1267 Phosphatidylglycerophosphatase A and related proteins
HMLCPHOH_02956 2e-199 yutH S Spore coat protein
HMLCPHOH_02957 2.7e-241 hom 1.1.1.3 E homoserine dehydrogenase
HMLCPHOH_02958 2.3e-198 thrC 4.2.3.1 E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HMLCPHOH_02959 8.6e-173 thrB 2.7.1.39 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
HMLCPHOH_02960 0.0 yuxL 3.4.14.5, 3.4.19.1 EU peptidase
HMLCPHOH_02961 1.2e-35 yutI O COG0694 Thioredoxin-like proteins and domains
HMLCPHOH_02962 3.5e-57 yuzD S protein conserved in bacteria
HMLCPHOH_02963 1.2e-199 yutJ 1.6.99.3 C NADH dehydrogenase
HMLCPHOH_02964 3.2e-39 yuzB S Belongs to the UPF0349 family
HMLCPHOH_02965 2.4e-199 yutK F Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HMLCPHOH_02966 2.2e-162 dapF 5.1.1.7 E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HMLCPHOH_02967 3.7e-63 erpA S Belongs to the HesB IscA family
HMLCPHOH_02968 4.7e-72 paiA 2.3.1.57 K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HMLCPHOH_02969 9e-118 paiB K Putative FMN-binding domain
HMLCPHOH_02970 4.9e-187 guaC 1.1.1.205, 1.7.1.7 F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
HMLCPHOH_02972 3.5e-188 yumC 1.18.1.2, 1.19.1.1 C reductase
HMLCPHOH_02973 2.5e-236 yumB 1.6.99.3 C NADH dehydrogenase
HMLCPHOH_02974 8.4e-27 yuiB S Putative membrane protein
HMLCPHOH_02975 9.5e-118 yuiC S protein conserved in bacteria
HMLCPHOH_02976 1.2e-77 yuiD S protein conserved in bacteria
HMLCPHOH_02977 1.5e-280 pepA 3.4.11.1, 3.4.11.5 E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HMLCPHOH_02978 3.9e-211 yuiF S antiporter
HMLCPHOH_02979 1.1e-93 bioY S Biotin biosynthesis protein
HMLCPHOH_02980 5.8e-122 yuiH S Oxidoreductase molybdopterin binding domain
HMLCPHOH_02981 1.3e-167 besA S Putative esterase
HMLCPHOH_02982 7.3e-141 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
HMLCPHOH_02983 2.3e-226 entC 5.4.4.2 HQ Isochorismate synthase
HMLCPHOH_02984 0.0 entE 2.7.7.58, 6.3.2.14 Q 2,3-dihydroxybenzoate-AMP ligase
HMLCPHOH_02985 1.4e-178 entB 3.3.2.1, 6.3.2.14 Q Isochorismatase family
HMLCPHOH_02986 0.0 dhbF Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HMLCPHOH_02987 3.8e-36 mbtH S MbtH-like protein
HMLCPHOH_02988 1.1e-132 yukJ S Uncharacterized conserved protein (DUF2278)
HMLCPHOH_02989 1.2e-205 ald 1.4.1.1 E Belongs to the AlaDH PNT family
HMLCPHOH_02990 6.5e-229 yukF QT Transcriptional regulator
HMLCPHOH_02991 2.8e-45 esxA S Belongs to the WXG100 family
HMLCPHOH_02992 7.7e-41 yukD S WXG100 protein secretion system (Wss), protein YukD
HMLCPHOH_02993 2.3e-211 essB S WXG100 protein secretion system (Wss), protein YukC
HMLCPHOH_02994 0.0 essC D COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins
HMLCPHOH_02995 0.0 esaA S type VII secretion protein EsaA
HMLCPHOH_02996 6.6e-65 yueC S Family of unknown function (DUF5383)
HMLCPHOH_02997 4.4e-132 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HMLCPHOH_02998 4.8e-96 yueE S phosphohydrolase
HMLCPHOH_02999 2.9e-24 S Protein of unknown function (DUF2642)
HMLCPHOH_03000 6.1e-72 S Protein of unknown function (DUF2283)
HMLCPHOH_03001 1.9e-190 yueF S transporter activity
HMLCPHOH_03002 2.1e-32 yueG S Spore germination protein gerPA/gerPF
HMLCPHOH_03003 7.4e-39 yueH S YueH-like protein
HMLCPHOH_03004 1.6e-67 yueI S Protein of unknown function (DUF1694)
HMLCPHOH_03005 2.9e-104 pncA Q COG1335 Amidases related to nicotinamidase
HMLCPHOH_03006 3.6e-266 pncB 6.3.4.21 H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HMLCPHOH_03007 2.2e-232 yuxH 3.1.4.52 T signal transduction protein containing EAL and modified HD-GYP domains
HMLCPHOH_03008 1.1e-22 yuzC
HMLCPHOH_03010 2.5e-162 comQ H Polyprenyl synthetase
HMLCPHOH_03012 0.0 comP 2.7.13.3 T Histidine kinase
HMLCPHOH_03013 5.1e-116 comA K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HMLCPHOH_03014 9.2e-65 ydiI Q protein, possibly involved in aromatic compounds catabolism
HMLCPHOH_03015 5.2e-60 phaG P COG1320 Multisubunit Na H antiporter, MnhG subunit
HMLCPHOH_03016 7.2e-38 phaF P Subunit F of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
HMLCPHOH_03017 4.8e-79 mrpE P Subunit E of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
HMLCPHOH_03018 3.8e-263 mrpD CP Subunit D of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
HMLCPHOH_03019 1.5e-50 phaC 1.6.5.3 P Subunit C of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
HMLCPHOH_03020 5.4e-69 mrpB P Subunit B of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
HMLCPHOH_03021 0.0 phaA 1.6.5.3 CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit
HMLCPHOH_03022 1.9e-14
HMLCPHOH_03023 1.3e-233 maeN C COG3493 Na citrate symporter
HMLCPHOH_03024 4.5e-169 yufQ S Belongs to the binding-protein-dependent transport system permease family
HMLCPHOH_03025 6.5e-185 yufP S Belongs to the binding-protein-dependent transport system permease family
HMLCPHOH_03026 1.1e-273 xylG 3.6.3.17 S ABC transporter, ATP-binding protein
HMLCPHOH_03027 3.4e-197 tcsA S ABC-type transport system, periplasmic component surface lipoprotein
HMLCPHOH_03028 2.3e-125 dcuR T COG4565 Response regulator of citrate malate metabolism
HMLCPHOH_03029 9.9e-294 dcuS 2.7.13.3 T Signal transduction histidine kinase regulating citrate malate metabolism
HMLCPHOH_03030 6.3e-78 yufK S Family of unknown function (DUF5366)
HMLCPHOH_03031 6.3e-75 yuxK S protein conserved in bacteria
HMLCPHOH_03032 0.0 mrcB 2.4.1.129, 3.4.16.4 GT51 M Penicillin-binding Protein
HMLCPHOH_03033 3.5e-186 yuxJ EGP Major facilitator Superfamily
HMLCPHOH_03035 1.9e-115 kapD L the KinA pathway to sporulation
HMLCPHOH_03036 2e-70 kapB G Kinase associated protein B
HMLCPHOH_03037 4.6e-233 T PhoQ Sensor
HMLCPHOH_03038 1.8e-228 patB 4.4.1.8 E COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
HMLCPHOH_03039 9.8e-42 yugE S Domain of unknown function (DUF1871)
HMLCPHOH_03040 1e-156 yugF I Hydrolase
HMLCPHOH_03041 1.6e-85 alaR K Transcriptional regulator
HMLCPHOH_03042 4.3e-200 yugH 2.6.1.1 E Aminotransferase
HMLCPHOH_03043 8.9e-63 yugI 5.3.1.9 J RNA binding protein (contains ribosomal protein S1 domain)
HMLCPHOH_03044 1.1e-34 yuzA S Domain of unknown function (DUF378)
HMLCPHOH_03045 8.9e-228 yugJ C oxidoreductases, Fe-dependent alcohol dehydrogenase family
HMLCPHOH_03046 2.8e-229 yugK C Dehydrogenase
HMLCPHOH_03047 4.2e-261 pgi 5.3.1.9 G Belongs to the GPI family
HMLCPHOH_03049 1.3e-72 yugN S YugN-like family
HMLCPHOH_03050 1.7e-182 yugO P COG1226 Kef-type K transport systems
HMLCPHOH_03051 1.1e-53 mstX S Membrane-integrating protein Mistic
HMLCPHOH_03052 4.6e-39
HMLCPHOH_03053 1.4e-116 yugP S Zn-dependent protease
HMLCPHOH_03054 2.6e-236 yugS S COG1253 Hemolysins and related proteins containing CBS domains
HMLCPHOH_03055 0.0 yugT 3.2.1.10, 3.2.1.20 GH13,GH31 G COG0366 Glycosidases
HMLCPHOH_03056 2.1e-72 yugU S Uncharacterised protein family UPF0047
HMLCPHOH_03057 1e-35
HMLCPHOH_03058 2.6e-140 tgl 2.3.2.13 S protein-glutamine gamma-glutamyltransferase activity
HMLCPHOH_03059 3.2e-225 mcpA NT chemotaxis protein
HMLCPHOH_03060 1.5e-222 mcpA NT chemotaxis protein
HMLCPHOH_03061 2.2e-295 mcpA NT chemotaxis protein
HMLCPHOH_03062 5.1e-239 mcpA NT chemotaxis protein
HMLCPHOH_03063 0.0 rhaD 1.1.1.1, 4.1.2.19 IQ Class II Aldolase and Adducin N-terminal domain
HMLCPHOH_03064 1e-134 fucR K COG1349 Transcriptional regulators of sugar metabolism
HMLCPHOH_03065 1.3e-281 rhaB 2.7.1.12, 2.7.1.17, 2.7.1.5, 5.3.1.14 G Involved in the catabolism of L-rhamnose (6-deoxy-L- mannose). Catalyzes the transfer of the gamma-phosphate group from ATP to the 1-hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate
HMLCPHOH_03066 2.5e-55 rhaM 5.1.3.32 G Involved in the anomeric conversion of L-rhamnose
HMLCPHOH_03067 1.4e-253 rhaA 2.7.1.5, 5.3.1.14 G Belongs to the rhamnose isomerase family
HMLCPHOH_03068 3.3e-183 ygjR S Oxidoreductase
HMLCPHOH_03069 6.3e-197 yubA S transporter activity
HMLCPHOH_03070 1.2e-133 uppP 3.6.1.27 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
HMLCPHOH_03072 2.6e-88 cdoA 1.13.11.20 S Cysteine dioxygenase type I
HMLCPHOH_03073 6.2e-277 yubD P Major Facilitator Superfamily
HMLCPHOH_03074 6.4e-153 NU Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
HMLCPHOH_03075 1e-38 yiaA S yiaA/B two helix domain
HMLCPHOH_03076 5.4e-237 ktrB P Potassium
HMLCPHOH_03077 5e-122 ktrA P COG0569 K transport systems, NAD-binding component
HMLCPHOH_03078 2.2e-91 yuaB
HMLCPHOH_03079 1.1e-95 yuaC K Belongs to the GbsR family
HMLCPHOH_03080 8e-282 gbsA 1.2.1.8 C Belongs to the aldehyde dehydrogenase family
HMLCPHOH_03081 2.9e-229 gbsB 1.1.1.1 C alcohol dehydrogenase
HMLCPHOH_03082 7.9e-108 yuaD
HMLCPHOH_03083 3.9e-84 yuaE S DinB superfamily
HMLCPHOH_03084 1.4e-77 yuaF OU Membrane protein implicated in regulation of membrane protease activity
HMLCPHOH_03085 4.1e-188 yuaG 3.4.21.72 S protein conserved in bacteria
HMLCPHOH_03086 3.4e-94 M1-753 M FR47-like protein
HMLCPHOH_03087 4.3e-90 thiT S Thiamine transporter protein (Thia_YuaJ)
HMLCPHOH_03088 6.7e-167 ygxA S Nucleotidyltransferase-like
HMLCPHOH_03089 1.5e-56 ygzB S UPF0295 protein
HMLCPHOH_03090 4e-80 perR P Belongs to the Fur family
HMLCPHOH_03091 2.8e-87 bcp 1.11.1.15 O Peroxiredoxin
HMLCPHOH_03092 1.2e-246 gsaB 5.4.3.8 H Glutamate-1-semialdehyde aminotransferase
HMLCPHOH_03093 8.7e-180 ygaE S Membrane
HMLCPHOH_03094 1.8e-301 ygaD V ABC transporter
HMLCPHOH_03095 1.3e-104 ygaC J Belongs to the UPF0374 family
HMLCPHOH_03096 1.5e-37 ygaB S YgaB-like protein
HMLCPHOH_03097 2.4e-08 sspE S Small, acid-soluble spore protein, gamma-type
HMLCPHOH_03098 2.9e-134 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HMLCPHOH_03099 6.9e-36 yfhS
HMLCPHOH_03100 7.8e-212 mutY L A G-specific
HMLCPHOH_03101 5.5e-186 yfhP S membrane-bound metal-dependent
HMLCPHOH_03102 0.0 yfhO S Bacterial membrane protein YfhO
HMLCPHOH_03103 2.7e-185 csbB GT2 M COG0463 Glycosyltransferases involved in cell wall biogenesis
HMLCPHOH_03104 6.7e-172 yfhM S Alpha beta hydrolase
HMLCPHOH_03105 3.5e-51 yfhL S SdpI/YhfL protein family
HMLCPHOH_03106 9.2e-92 batE T Bacterial SH3 domain homologues
HMLCPHOH_03107 1.3e-44 yfhJ S WVELL protein
HMLCPHOH_03108 6.2e-20 sspK S reproduction
HMLCPHOH_03109 1.1e-209 yfhI EGP Major facilitator Superfamily
HMLCPHOH_03111 9.7e-52 yfhH S Protein of unknown function (DUF1811)
HMLCPHOH_03112 1.1e-141 recX 2.4.1.337 GT4 S Modulates RecA activity
HMLCPHOH_03113 4.9e-173 yfhF S nucleoside-diphosphate sugar epimerase
HMLCPHOH_03115 2.1e-25 yfhD S YfhD-like protein
HMLCPHOH_03116 3.9e-107 yfhC C nitroreductase
HMLCPHOH_03117 1.5e-166 yfhB 5.3.3.17 S PhzF family
HMLCPHOH_03118 5.2e-171 yfhA P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMLCPHOH_03119 3.1e-176 yfiZ P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMLCPHOH_03120 6.2e-182 yfiY P ABC transporter substrate-binding protein
HMLCPHOH_03121 0.0 mprF 2.3.2.3 S Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HMLCPHOH_03122 3.1e-81 yfiV K transcriptional
HMLCPHOH_03123 8.7e-287 yfiU EGP Major facilitator Superfamily
HMLCPHOH_03124 3.3e-100 yfiT S Belongs to the metal hydrolase YfiT family
HMLCPHOH_03125 5.1e-221 yfiS EGP Major facilitator Superfamily
HMLCPHOH_03126 2e-109 yfiR K Transcriptional regulator
HMLCPHOH_03127 9e-198 yfiQ G COG3936 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HMLCPHOH_03128 4.4e-80 estA 3.1.1.3 S acetyltransferases and hydrolases with the alpha beta hydrolase fold
HMLCPHOH_03129 8.3e-99 padR K transcriptional
HMLCPHOH_03130 4.6e-208 V COG0842 ABC-type multidrug transport system, permease component
HMLCPHOH_03131 9.8e-214 V ABC-2 family transporter protein
HMLCPHOH_03132 6.2e-171 V ABC transporter, ATP-binding protein
HMLCPHOH_03133 3.2e-113 KT LuxR family transcriptional regulator
HMLCPHOH_03134 1.1e-214 yxjM T Histidine kinase
HMLCPHOH_03136 1.1e-233 S Oxidoreductase
HMLCPHOH_03137 8.4e-184 G Xylose isomerase
HMLCPHOH_03138 1.8e-262 iolT EGP Major facilitator Superfamily
HMLCPHOH_03139 1.5e-177 K AraC-like ligand binding domain
HMLCPHOH_03140 5.7e-163 yfiE 1.13.11.2 S glyoxalase
HMLCPHOH_03141 9.8e-65 mhqP S DoxX
HMLCPHOH_03142 0.0 yfiC V COG1132 ABC-type multidrug transport system, ATPase and permease components
HMLCPHOH_03143 2.1e-310 yfiB3 V ABC transporter
HMLCPHOH_03144 4.7e-296 glvC 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
HMLCPHOH_03145 3.2e-141 glvR K Helix-turn-helix domain, rpiR family
HMLCPHOH_03146 9.9e-263 aglB 3.2.1.122, 3.2.1.22, 3.2.1.86 GH4,GT4 G COG1486 Alpha-galactosidases 6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases
HMLCPHOH_03147 1.1e-44 yfjA S Belongs to the WXG100 family
HMLCPHOH_03148 9.2e-191 yfjB
HMLCPHOH_03149 4.1e-144 yfjC
HMLCPHOH_03150 1.8e-101 yfjD S Family of unknown function (DUF5381)
HMLCPHOH_03151 1.3e-80 S Family of unknown function (DUF5381)
HMLCPHOH_03152 4e-56 yfjF S UPF0060 membrane protein
HMLCPHOH_03153 1.2e-25 sspH S Belongs to the SspH family
HMLCPHOH_03154 0.0 acoR KQ COG3284 Transcriptional activator of acetoin glycerol metabolism
HMLCPHOH_03155 6.4e-257 acoL 1.8.1.4 C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
HMLCPHOH_03156 2.9e-197 acoC 2.3.1.12, 2.3.1.61 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
HMLCPHOH_03157 1e-190 acoB C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
HMLCPHOH_03158 1.2e-191 acoA C COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
HMLCPHOH_03159 3e-29 yfjL
HMLCPHOH_03160 3.9e-86 yfjM S Psort location Cytoplasmic, score
HMLCPHOH_03161 5.1e-192 yfjN J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HMLCPHOH_03162 1.6e-39 S YfzA-like protein
HMLCPHOH_03163 1.1e-267 rumA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HMLCPHOH_03164 1e-167 yfjP 3.2.2.21 L COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HMLCPHOH_03165 1.7e-184 corA P Mediates influx of magnesium ions
HMLCPHOH_03166 4.2e-150 yfjR 1.1.1.31 I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
HMLCPHOH_03167 2.6e-154 pdaA G deacetylase
HMLCPHOH_03168 1.1e-26 yfjT
HMLCPHOH_03169 5.4e-222 yfkA S YfkB-like domain
HMLCPHOH_03170 6e-149 yfkC M Mechanosensitive ion channel
HMLCPHOH_03171 1.2e-146 yfkD S YfkD-like protein
HMLCPHOH_03172 6.1e-183 cax P COG0387 Ca2 H antiporter
HMLCPHOH_03173 1.5e-219 ycaD EGP COG0477 Permeases of the major facilitator superfamily
HMLCPHOH_03174 5e-08
HMLCPHOH_03175 9.7e-144 yihY S Belongs to the UPF0761 family
HMLCPHOH_03176 8.4e-51 yfkI S gas vesicle protein
HMLCPHOH_03177 2.2e-84 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HMLCPHOH_03178 2.1e-29 yfkK S Belongs to the UPF0435 family
HMLCPHOH_03179 6.8e-207 ydiM EGP Major facilitator Superfamily
HMLCPHOH_03180 1.6e-91 yfkM 1.11.1.6, 3.5.1.124 S protease
HMLCPHOH_03181 0.0 cpdB 3.1.3.5, 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
HMLCPHOH_03182 1.6e-125 yfkO C nitroreductase
HMLCPHOH_03183 1.8e-133 treR K transcriptional
HMLCPHOH_03184 0.0 treC 3.2.1.93 GH13 G COG0366 Glycosidases
HMLCPHOH_03185 8.5e-257 treP 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
HMLCPHOH_03186 1.5e-283 yfkQ EG Spore germination protein
HMLCPHOH_03187 5.1e-207 yfkR S spore germination
HMLCPHOH_03189 1.6e-194 E Spore germination protein
HMLCPHOH_03190 3.2e-256 agcS_1 E Sodium alanine symporter
HMLCPHOH_03191 6e-67 yhdN S Domain of unknown function (DUF1992)
HMLCPHOH_03192 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
HMLCPHOH_03193 1.1e-250 nagE 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G COG1263 Phosphotransferase system IIC components, glucose maltose N-acetylglucosamine-specific
HMLCPHOH_03194 1.1e-138 map 3.4.11.18 E Methionine aminopeptidase
HMLCPHOH_03195 2.4e-50 yflH S Protein of unknown function (DUF3243)
HMLCPHOH_03196 4.1e-19 yflI
HMLCPHOH_03197 4e-18 yflJ S Protein of unknown function (DUF2639)
HMLCPHOH_03198 9e-124 yflK S protein conserved in bacteria
HMLCPHOH_03199 2.9e-44 acyP 3.6.1.7 C Belongs to the acylphosphatase family
HMLCPHOH_03200 1.3e-217 nos 1.14.14.47 C Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HMLCPHOH_03201 5.5e-152 yflN S COG0491 Zn-dependent hydrolases, including glyoxylases
HMLCPHOH_03202 8.5e-227 citM C Citrate transporter
HMLCPHOH_03204 3e-181 yflP S Tripartite tricarboxylate transporter family receptor
HMLCPHOH_03205 8.9e-119 citT T response regulator
HMLCPHOH_03206 1e-290 citS 2.7.13.3 T Signal transduction histidine kinase regulating citrate malate metabolism
HMLCPHOH_03207 3.2e-235 yflS P Sodium:sulfate symporter transmembrane region
HMLCPHOH_03208 3.8e-240 pel 4.2.2.10, 4.2.2.2 G Pectate lyase
HMLCPHOH_03209 7.6e-58 yflT S Heat induced stress protein YflT
HMLCPHOH_03210 2.9e-24 S Protein of unknown function (DUF3212)
HMLCPHOH_03211 3.4e-169 fecB P COG4594 ABC-type Fe3 -citrate transport system, periplasmic component
HMLCPHOH_03212 4.3e-170 viuD P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMLCPHOH_03213 1.2e-169 fecD P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMLCPHOH_03214 1.1e-149 yfmF 3.6.3.34 P ATPases associated with a variety of cellular activities
HMLCPHOH_03215 3.3e-296 1.14.99.50 S Sulfatase-modifying factor enzyme 1
HMLCPHOH_03216 7.7e-214 G Major Facilitator Superfamily
HMLCPHOH_03217 8.5e-190 yfmJ S N-terminal domain of oxidoreductase
HMLCPHOH_03218 7.5e-82 yfmK 2.3.1.128 K acetyltransferase
HMLCPHOH_03219 6.3e-202 yfmL 3.6.4.13 L COG0513 Superfamily II DNA and RNA helicases
HMLCPHOH_03220 1.9e-297 yfmM S COG0488 ATPase components of ABC transporters with duplicated ATPase domains
HMLCPHOH_03221 1.5e-209 yfmO EGP Major facilitator Superfamily
HMLCPHOH_03222 2.8e-70 yfmP K transcriptional
HMLCPHOH_03223 3e-75 yfmQ S Uncharacterised protein from bacillus cereus group
HMLCPHOH_03224 0.0 yfmR S COG0488 ATPase components of ABC transporters with duplicated ATPase domains
HMLCPHOH_03225 1.1e-113 yfmS NT chemotaxis protein
HMLCPHOH_03226 2.8e-279 yfmT 1.2.1.3, 1.2.1.67 C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
HMLCPHOH_03227 1.3e-241 yfnA E amino acid
HMLCPHOH_03228 7.8e-134 yjjG 3.1.3.102, 3.1.3.104, 3.1.3.5, 3.8.1.2 S Haloacid dehalogenase-like hydrolase
HMLCPHOH_03229 2e-206 fsr P COG0477 Permeases of the major facilitator superfamily
HMLCPHOH_03230 3.5e-190 yfnD M Nucleotide-diphospho-sugar transferase
HMLCPHOH_03231 1.4e-225 yfnE 2.4.1.338 GT2 S Glycosyltransferase like family 2
HMLCPHOH_03232 3.8e-181 yfnF M Nucleotide-diphospho-sugar transferase
HMLCPHOH_03233 1.9e-172 yfnG 4.2.1.45 M dehydratase
HMLCPHOH_03234 2.1e-148 rfbF 2.7.7.33 JM Nucleotidyl transferase
HMLCPHOH_03235 0.0 ltaS 2.7.8.20 M Belongs to the LTA synthase family
HMLCPHOH_03236 0.0 cypD 1.14.14.1, 1.6.2.4 C Belongs to the cytochrome P450 family
HMLCPHOH_03237 3.6e-199 yetN S Protein of unknown function (DUF3900)
HMLCPHOH_03238 7.8e-213 yetM CH FAD binding domain
HMLCPHOH_03239 6.4e-90 yetL K helix_turn_helix multiple antibiotic resistance protein
HMLCPHOH_03240 5.4e-159 yetK EG EamA-like transporter family
HMLCPHOH_03241 5.3e-105 yetJ S Belongs to the BI1 family
HMLCPHOH_03242 8.9e-20 yezD S Uncharacterized small protein (DUF2292)
HMLCPHOH_03243 4.4e-43 T COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
HMLCPHOH_03244 2.2e-89 T COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
HMLCPHOH_03245 2.2e-34
HMLCPHOH_03246 2e-64 yetH E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HMLCPHOH_03247 4.4e-55 isdI 1.14.99.48, 1.14.99.57 S Antibiotic biosynthesis monooxygenase
HMLCPHOH_03248 6.1e-123 yetF S membrane
HMLCPHOH_03249 3.3e-258 lplD 3.2.1.122, 3.2.1.22, 3.2.1.86 GH4,GT4 G Family 4 glycosyl hydrolase
HMLCPHOH_03250 1.7e-162 lplC G Binding-protein-dependent transport system inner membrane component
HMLCPHOH_03251 1.3e-176 lplB G COG4209 ABC-type polysaccharide transport system, permease component
HMLCPHOH_03252 9.6e-291 lplA G Bacterial extracellular solute-binding protein
HMLCPHOH_03253 0.0 yetA
HMLCPHOH_03254 0.0 yesZ 3.2.1.23 G beta-galactosidase activity
HMLCPHOH_03255 3e-124 yesY E GDSL-like Lipase/Acylhydrolase
HMLCPHOH_03256 0.0 yesX 4.2.2.23, 4.2.2.24 PL11 E cell wall organization
HMLCPHOH_03257 0.0 yesX 4.2.2.23, 4.2.2.24 PL11 E cell wall organization
HMLCPHOH_03258 1e-113 yesV S Protein of unknown function, DUF624
HMLCPHOH_03259 8.9e-132 yesU S Domain of unknown function (DUF1961)
HMLCPHOH_03260 3.8e-133 E GDSL-like Lipase/Acylhydrolase
HMLCPHOH_03261 0.0 yesS K Transcriptional regulator
HMLCPHOH_03262 1.6e-199 3.2.1.172 GH105 S Glycosyl Hydrolase Family 88
HMLCPHOH_03263 1.3e-165 yesQ P Binding-protein-dependent transport system inner membrane component
HMLCPHOH_03264 2.8e-171 yesP G Binding-protein-dependent transport system inner membrane component
HMLCPHOH_03265 5e-248 yesO G Bacterial extracellular solute-binding protein
HMLCPHOH_03266 2.9e-204 yesN K helix_turn_helix, arabinose operon control protein
HMLCPHOH_03267 0.0 yesM 2.7.13.3 T Histidine kinase
HMLCPHOH_03268 4.4e-104 yesL S Protein of unknown function, DUF624
HMLCPHOH_03270 4.2e-103 yesJ K Acetyltransferase (GNAT) family
HMLCPHOH_03271 5.2e-104 cotJC P Spore Coat
HMLCPHOH_03272 1.5e-45 cotJB S CotJB protein
HMLCPHOH_03273 5.3e-45 cotJA S Spore coat associated protein JA (CotJA)
HMLCPHOH_03274 5e-159 yesF GM NAD(P)H-binding
HMLCPHOH_03275 9.7e-82 yesE S SnoaL-like domain
HMLCPHOH_03276 1.2e-103 dhaR3 K Transcriptional regulator
HMLCPHOH_03278 9.4e-127 yeeN K transcriptional regulatory protein
HMLCPHOH_03280 5.5e-214 S Tetratricopeptide repeat
HMLCPHOH_03281 1.8e-192 3.4.24.40 CO amine dehydrogenase activity
HMLCPHOH_03282 0.0 L nucleic acid phosphodiester bond hydrolysis
HMLCPHOH_03283 5.5e-83 S Protein of unknown function, DUF600
HMLCPHOH_03284 6.2e-31 S Colicin immunity protein / pyocin immunity protein
HMLCPHOH_03286 1.2e-211 pstS P T5orf172
HMLCPHOH_03287 0.0 yeeB L DEAD-like helicases superfamily
HMLCPHOH_03288 0.0 yeeA V Type II restriction enzyme, methylase subunits
HMLCPHOH_03289 3.2e-53 L Resolvase, N terminal domain
HMLCPHOH_03290 3.2e-98 L Recombinase
HMLCPHOH_03291 1.2e-255 rumA 2.1.1.190 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HMLCPHOH_03292 3e-170 yegS 2.7.1.107 I COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
HMLCPHOH_03293 0.0 swrC V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HMLCPHOH_03294 4e-156 yerO K Transcriptional regulator
HMLCPHOH_03295 3.1e-270 gatB 6.1.1.12, 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HMLCPHOH_03296 1.2e-274 gatA 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
HMLCPHOH_03297 2.1e-45 gatC 6.3.5.6, 6.3.5.7 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HMLCPHOH_03298 2e-264 putP E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HMLCPHOH_03299 1.6e-123 sapB S MgtC SapB transporter
HMLCPHOH_03300 1.1e-197 yerI S homoserine kinase type II (protein kinase fold)
HMLCPHOH_03301 4.1e-220 camS S COG4851 Protein involved in sex pheromone biosynthesis
HMLCPHOH_03302 0.0 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HMLCPHOH_03303 0.0 pcrA 3.6.4.12 L ATP-dependent DNA helicase
HMLCPHOH_03304 2.2e-125 pcrB I 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HMLCPHOH_03306 3.2e-305 yerD 1.4.7.1 E Belongs to the glutamate synthase family
HMLCPHOH_03307 4.8e-51 yerC S protein conserved in bacteria
HMLCPHOH_03308 3e-192 yerB S Protein of unknown function (DUF3048) C-terminal domain
HMLCPHOH_03309 0.0 yerA 3.5.4.2 F adenine deaminase
HMLCPHOH_03310 2.7e-27 S Protein of unknown function (DUF2892)
HMLCPHOH_03311 2.3e-232 yjeH E Amino acid permease
HMLCPHOH_03312 3.5e-73 K helix_turn_helix ASNC type
HMLCPHOH_03313 1.7e-235 purD 6.3.4.13 F Belongs to the GARS family
HMLCPHOH_03314 3.5e-288 purH 2.1.2.3, 3.5.4.10 F Bifunctional purine biosynthesis protein PurH
HMLCPHOH_03315 3.7e-105 purN 2.1.2.2 F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HMLCPHOH_03316 3.2e-176 purM 6.3.3.1, 6.3.4.13 F Phosphoribosylformylglycinamidine cyclo-ligase
HMLCPHOH_03317 1.2e-271 purF 2.4.2.14 F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HMLCPHOH_03318 0.0 purL 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HMLCPHOH_03319 5.1e-130 purQ 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HMLCPHOH_03320 2.9e-38 purS 6.3.2.6, 6.3.5.3 F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HMLCPHOH_03321 1.2e-132 purC 4.1.1.21, 4.3.2.2, 6.3.2.6 F Belongs to the SAICAR synthetase family
HMLCPHOH_03322 2.1e-246 purB 4.3.2.2 F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HMLCPHOH_03323 7e-217 purK 6.3.4.18 F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HMLCPHOH_03324 2.5e-83 purE 5.4.99.18 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HMLCPHOH_03325 8e-28 yebG S NETI protein
HMLCPHOH_03326 4e-93 yebE S UPF0316 protein
HMLCPHOH_03328 1.1e-118 yebC M Membrane
HMLCPHOH_03329 6e-212 pbuG S permease
HMLCPHOH_03330 9.8e-256 S Domain of unknown function (DUF4179)
HMLCPHOH_03331 2e-89 K Belongs to the sigma-70 factor family. ECF subfamily
HMLCPHOH_03332 3.7e-306 guaA 2.3.1.128, 6.3.5.2 F Catalyzes the synthesis of GMP from XMP
HMLCPHOH_03333 0.0 yebA E COG1305 Transglutaminase-like enzymes
HMLCPHOH_03334 9.5e-225 yeaD S conserved protein (some members contain a von Willebrand factor type A (vWA) domain)
HMLCPHOH_03335 1.6e-177 yeaC S COG0714 MoxR-like ATPases
HMLCPHOH_03336 7.6e-155 yeaB P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HMLCPHOH_03337 2.6e-253 gabP E COG1113 Gamma-aminobutyrate permease and related permeases
HMLCPHOH_03338 0.0 cotA 1.10.3.4, 1.16.3.3 Q multicopper oxidases
HMLCPHOH_03339 3.3e-175 yeaA S Protein of unknown function (DUF4003)
HMLCPHOH_03340 8.4e-156 ydjP I Alpha/beta hydrolase family
HMLCPHOH_03341 1.4e-34 ydjO S Cold-inducible protein YdjO
HMLCPHOH_03343 2.3e-150 ydjN U Involved in the tonB-independent uptake of proteins
HMLCPHOH_03344 4.5e-64 ydjM M Lytic transglycolase
HMLCPHOH_03345 5.2e-195 bdhA 1.1.1.303, 1.1.1.4 E Dehydrogenase
HMLCPHOH_03346 2.7e-258 iolT EGP Major facilitator Superfamily
HMLCPHOH_03347 4.7e-196 S Ion transport 2 domain protein
HMLCPHOH_03348 1.4e-149 ydjI S virion core protein (lumpy skin disease virus)
HMLCPHOH_03349 1.6e-137 ydjH S COG1512 Beta-propeller domains of methanol dehydrogenase type
HMLCPHOH_03350 3.4e-178 ydjG 3.6.4.12 L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HMLCPHOH_03351 5.1e-114 pspA KT Phage shock protein A
HMLCPHOH_03352 1.5e-175 ydjE 2.7.1.4 G pfkB family carbohydrate kinase
HMLCPHOH_03353 7.1e-256 gutA G MFS/sugar transport protein
HMLCPHOH_03354 3.8e-201 gutB 1.1.1.14 E Dehydrogenase
HMLCPHOH_03355 0.0 K NB-ARC domain
HMLCPHOH_03356 1.1e-08 ydjC S Abhydrolase domain containing 18
HMLCPHOH_03357 4.9e-257 J LlaJI restriction endonuclease
HMLCPHOH_03358 1.2e-199 V AAA domain (dynein-related subfamily)
HMLCPHOH_03360 1.6e-232 ydiP 2.1.1.37 H Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family
HMLCPHOH_03361 1.1e-250 2.1.1.37 L DNA (cytosine-5-)-methyltransferase activity
HMLCPHOH_03362 6.4e-66 KL Phage plasmid primase P4 family
HMLCPHOH_03364 1.2e-281 groL O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
HMLCPHOH_03365 1.3e-42 groS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HMLCPHOH_03366 7.9e-129 ydiL S CAAX protease self-immunity
HMLCPHOH_03367 2.9e-27 ydiK S Domain of unknown function (DUF4305)
HMLCPHOH_03368 8.4e-126 tatC U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HMLCPHOH_03369 7.5e-22 tatA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
HMLCPHOH_03370 8.8e-116 rex K Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HMLCPHOH_03371 5.5e-89 moaC 4.6.1.17 H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)
HMLCPHOH_03372 0.0 ydiF S ABC transporter
HMLCPHOH_03373 3.6e-188 tsaD 2.3.1.234 O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HMLCPHOH_03374 1.3e-84 rimI 2.3.1.128 K This enzyme acetylates the N-terminal alanine of ribosomal protein S18
HMLCPHOH_03375 9e-127 yeaZ 2.3.1.234 O COG1214 Inactive homolog of metal-dependent proteases
HMLCPHOH_03376 9.1e-86 ydiB 2.7.1.221, 5.1.1.1 S ATPase or kinase
HMLCPHOH_03377 4.6e-185 thiL 2.7.4.16 H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HMLCPHOH_03379 7.8e-08
HMLCPHOH_03380 7.2e-250 srfAB Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HMLCPHOH_03381 0.0 srfAC Q COG1020 Non-ribosomal peptide synthetase modules and related proteins
HMLCPHOH_03382 5.7e-140 srfAD Q thioesterase
HMLCPHOH_03383 4.2e-228 EGP Major Facilitator Superfamily
HMLCPHOH_03384 4.9e-91 S YcxB-like protein
HMLCPHOH_03385 7.4e-164 ycxC EG EamA-like transporter family
HMLCPHOH_03386 4.4e-255 ycxD K GntR family transcriptional regulator
HMLCPHOH_03387 5.5e-113 acpT 2.7.8.7 H Belongs to the P-Pant transferase superfamily
HMLCPHOH_03388 4.4e-115 yczE S membrane
HMLCPHOH_03389 2.8e-134 tcyC 3.6.3.21 E COG1126 ABC-type polar amino acid transport system, ATPase component
HMLCPHOH_03390 6.2e-123 tcyB P COG0765 ABC-type amino acid transport system, permease component
HMLCPHOH_03391 1.5e-141 tcyA ET Belongs to the bacterial solute-binding protein 3 family
HMLCPHOH_03392 4.9e-162 bsdA K LysR substrate binding domain
HMLCPHOH_03393 2e-109 ubiX 2.5.1.129 H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN
HMLCPHOH_03394 1.8e-283 yclC 4.1.1.61 H Decarboxylase involved in the decarboxylation and detoxification of phenolic derivatives under both aerobic and anaerobic conditions. It is able to catalyze the reversible decarboxylation of 4-hydroxybenzoate
HMLCPHOH_03395 4e-39 bsdD 4.1.1.61 S response to toxic substance
HMLCPHOH_03396 1.1e-83 yclD
HMLCPHOH_03397 6.2e-162 yclE 3.4.11.5 S Alpha beta hydrolase
HMLCPHOH_03398 1.5e-267 dtpT E amino acid peptide transporter
HMLCPHOH_03399 2.9e-310 yclG M Pectate lyase superfamily protein
HMLCPHOH_03401 6.8e-282 gerKA EG Spore germination protein
HMLCPHOH_03402 1.3e-232 gerKC S spore germination
HMLCPHOH_03403 9.9e-200 gerKB F Spore germination protein
HMLCPHOH_03404 3.9e-122 yclH P ABC transporter
HMLCPHOH_03405 1.7e-204 yclI V ABC transporter (permease) YclI
HMLCPHOH_03406 1.4e-127 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HMLCPHOH_03407 1.8e-262 yclK 2.7.13.3 T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain
HMLCPHOH_03408 5.2e-71 S aspartate phosphatase
HMLCPHOH_03411 7.5e-242 lysC 2.7.2.4 E Belongs to the aspartokinase family
HMLCPHOH_03412 1.6e-161 yclN P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMLCPHOH_03413 2.6e-164 fatC P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMLCPHOH_03414 4.7e-137 yclP 3.6.3.34 P ABC transporter, ATP-binding protein
HMLCPHOH_03415 5.5e-175 yclQ P COG4607 ABC-type enterochelin transport system, periplasmic component
HMLCPHOH_03416 1.4e-251 ycnB EGP Major facilitator Superfamily
HMLCPHOH_03417 6.5e-154 ycnC K Transcriptional regulator
HMLCPHOH_03418 4.4e-135 nfrA2 1.5.1.38, 1.5.1.39 C Oxidoreductase
HMLCPHOH_03419 1.6e-45 ycnE S Monooxygenase
HMLCPHOH_03420 2.2e-51 yczG K helix_turn_helix, Arsenical Resistance Operon Repressor
HMLCPHOH_03421 1.3e-273 gabR K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
HMLCPHOH_03422 4.4e-247 gabT 2.6.1.19, 2.6.1.22 E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HMLCPHOH_03423 3.4e-266 gabD 1.2.1.16, 1.2.1.20, 1.2.1.79 C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
HMLCPHOH_03424 6.1e-149 glcU U Glucose uptake
HMLCPHOH_03425 9.9e-146 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HMLCPHOH_03426 1.3e-100 ycnI S protein conserved in bacteria
HMLCPHOH_03427 1.4e-308 ycnJ P protein, homolog of Cu resistance protein CopC
HMLCPHOH_03428 1.7e-107 ycnK K COG1349 Transcriptional regulators of sugar metabolism
HMLCPHOH_03429 7.3e-56
HMLCPHOH_03430 5.6e-240 mtlA 2.7.1.197 G COG2213 Phosphotransferase system, mannitol-specific IIBC component
HMLCPHOH_03431 2e-71 mtlF 2.7.1.197 G COG4668 Mannitol fructose-specific phosphotransferase system, IIA domain
HMLCPHOH_03432 7.3e-211 mtlD 1.1.1.17 G COG0246 Mannitol-1-phosphate altronate dehydrogenases
HMLCPHOH_03433 3.8e-201 ycsA 1.1.1.83, 1.1.1.93, 4.1.1.73 CE Tartrate dehydrogenase
HMLCPHOH_03434 3.2e-10 sipT 3.4.21.89 U Belongs to the peptidase S26 family
HMLCPHOH_03435 7.6e-76 sipT 3.4.21.89 U Belongs to the peptidase S26 family
HMLCPHOH_03436 5e-113 M1-673 3.1.1.45 Q COG0412 Dienelactone hydrolase and related enzymes
HMLCPHOH_03437 5.4e-68 fabZ 3.5.1.108, 4.2.1.59 I FabA-like domain
HMLCPHOH_03439 8e-137 ycsE 3.1.3.104 S Sucrose-6F-phosphate phosphohydrolase
HMLCPHOH_03440 1.2e-140 ycsF S Belongs to the UPF0271 (lamB) family
HMLCPHOH_03441 6.5e-213 ycsG P COG1914 Mn2 and Fe2 transporters of the NRAMP family
HMLCPHOH_03442 9.6e-149 ycsI S Belongs to the D-glutamate cyclase family
HMLCPHOH_03443 1.9e-135 kipI 3.5.1.54 E Allophanate hydrolase subunit 1
HMLCPHOH_03444 5.1e-187 kipA 6.3.4.6 E Allophanate hydrolase subunit 2
HMLCPHOH_03445 1.2e-132 kipR K Transcriptional regulator
HMLCPHOH_03446 9.9e-120 ycsK E anatomical structure formation involved in morphogenesis
HMLCPHOH_03448 1.4e-49 yczJ S biosynthesis
HMLCPHOH_03449 0.0 pbpC 3.4.16.4 M Penicillin-binding Protein
HMLCPHOH_03450 2.8e-176 ydhF S Oxidoreductase
HMLCPHOH_03451 0.0 mtlR K transcriptional regulator, MtlR
HMLCPHOH_03452 1.4e-294 ydaB IQ acyl-CoA ligase
HMLCPHOH_03453 1.1e-99 ydaC Q Methyltransferase domain
HMLCPHOH_03454 1.4e-161 IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HMLCPHOH_03455 1.2e-96 MA20_27600 5.3.1.15 S Cupin 2, conserved barrel domain protein
HMLCPHOH_03456 5e-104 rimL 1.1.1.25 J COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
HMLCPHOH_03457 6.8e-77 ydaG 1.4.3.5 S general stress protein
HMLCPHOH_03458 4.1e-139 amj U Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane
HMLCPHOH_03459 5.1e-47 ydzA EGP Major facilitator Superfamily
HMLCPHOH_03460 2.5e-74 lrpC K Transcriptional regulator
HMLCPHOH_03461 0.0 topB 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HMLCPHOH_03462 1.9e-208 ydaJ M Belongs to the glycosyl hydrolase 8 (cellulase D) family
HMLCPHOH_03463 2e-152 ydaK T Diguanylate cyclase, GGDEF domain
HMLCPHOH_03464 0.0 ydaL S Uncharacterized protein conserved in bacteria (DUF2334)
HMLCPHOH_03465 4.5e-233 ydaM M Glycosyl transferase family group 2
HMLCPHOH_03466 0.0 ydaN S Bacterial cellulose synthase subunit
HMLCPHOH_03467 0.0 ydaO E amino acid
HMLCPHOH_03468 4.6e-79 mutT 3.6.1.13, 3.6.1.55 L Belongs to the Nudix hydrolase family
HMLCPHOH_03469 0.0 poxB 1.2.3.3, 1.2.5.1 EH Belongs to the TPP enzyme family
HMLCPHOH_03470 9.4e-40
HMLCPHOH_03471 1e-224 mntH P H( )-stimulated, divalent metal cation uptake system
HMLCPHOH_03473 3.3e-77 ydaT S Uncharacterized protein conserved in bacteria (DUF2188)
HMLCPHOH_03474 3.8e-148 ydbA 3.6.3.4, 3.6.3.54 P EcsC protein family
HMLCPHOH_03476 8.9e-59 ydbB G Cupin domain
HMLCPHOH_03477 2.8e-63 ydbC S Domain of unknown function (DUF4937
HMLCPHOH_03478 3.2e-155 ydbD P Catalase
HMLCPHOH_03479 2.7e-199 dctB G COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component
HMLCPHOH_03480 2.5e-297 dctS 2.7.13.3 T Signal transduction histidine kinase regulating citrate malate metabolism
HMLCPHOH_03481 8.1e-120 dctR T COG4565 Response regulator of citrate malate metabolism
HMLCPHOH_03482 6.3e-227 dctA U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
HMLCPHOH_03483 4.4e-181 ydbI S AI-2E family transporter
HMLCPHOH_03484 3.6e-171 ydbJ V ABC transporter, ATP-binding protein
HMLCPHOH_03485 5.5e-125 ydbK S COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
HMLCPHOH_03486 2.7e-52 ydbL
HMLCPHOH_03487 3e-220 ydbM 1.3.8.1 I acyl-CoA dehydrogenase
HMLCPHOH_03488 1.1e-18 S Fur-regulated basic protein B
HMLCPHOH_03489 2.2e-07 S Fur-regulated basic protein A
HMLCPHOH_03490 1.9e-150 yeaB P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HMLCPHOH_03491 2.3e-56 ydbP 2.7.1.180, 5.3.4.1 CO Thioredoxin
HMLCPHOH_03492 4.6e-202 ddl 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
HMLCPHOH_03493 1.9e-259 murF 6.3.2.10 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
HMLCPHOH_03494 9e-249 cshA 3.6.4.13 JKL DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
HMLCPHOH_03495 2.1e-82 ydbS S Bacterial PH domain
HMLCPHOH_03496 2.2e-263 ydbT S Membrane
HMLCPHOH_03497 1.8e-107 ydcA 3.4.21.105 S membrane protein (homolog of Drosophila rhomboid)
HMLCPHOH_03498 2.5e-59 acpS 2.7.6.3, 2.7.8.7, 5.1.1.1 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
HMLCPHOH_03499 2.9e-183 ydcC M COG2834 Outer membrane lipoprotein-sorting protein
HMLCPHOH_03500 2.3e-223 alr 5.1.1.1, 5.1.1.5 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HMLCPHOH_03501 4.8e-42 ndoAI K transcriptional regulators containing the CopG Arc MetJ DNA-binding domain and a metal-binding domain
HMLCPHOH_03502 2.5e-56 ndoA L Toxic component of a toxin-antitoxin (TA) module
HMLCPHOH_03503 1.3e-143 rsbR T Positive regulator of sigma-B
HMLCPHOH_03504 5.2e-57 rsbS T antagonist
HMLCPHOH_03505 1.3e-69 rsbT 2.7.11.1 T COG2172 Anti-sigma regulatory factor (Ser Thr protein kinase)
HMLCPHOH_03506 7.1e-189 rsbU 3.1.3.3 KT phosphatase
HMLCPHOH_03507 7e-53 rsbV T Belongs to the anti-sigma-factor antagonist family
HMLCPHOH_03508 2.4e-86 rsbW 2.7.11.1 F Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B)
HMLCPHOH_03509 3.4e-138 sigB K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HMLCPHOH_03510 4.8e-108 rsbX 3.1.3.16, 3.1.3.3 KT Sigma factor PP2C-like phosphatases
HMLCPHOH_03514 1.5e-82 ydcG S EVE domain
HMLCPHOH_03515 1.6e-76 ydcH K helix_turn_helix multiple antibiotic resistance protein
HMLCPHOH_03516 0.0 yhgF K COG2183 Transcriptional accessory protein
HMLCPHOH_03517 1.6e-84 ydcK S Belongs to the SprT family
HMLCPHOH_03525 1.9e-211 L Belongs to the 'phage' integrase family
HMLCPHOH_03526 1.3e-90 immA E IrrE N-terminal-like domain
HMLCPHOH_03527 4.3e-62 yvaO K Transcriptional
HMLCPHOH_03528 1.1e-16
HMLCPHOH_03529 8.3e-41
HMLCPHOH_03531 5.1e-63 S Bacterial protein of unknown function (DUF961)
HMLCPHOH_03532 1e-273 ydcQ D Ftsk spoiiie family protein
HMLCPHOH_03533 1.5e-205 nicK L Replication initiation factor
HMLCPHOH_03536 1.2e-32 yddA
HMLCPHOH_03537 1.5e-173 yddB S Conjugative transposon protein TcpC
HMLCPHOH_03538 3e-40 yddC
HMLCPHOH_03539 2.4e-95 yddD S TcpE family
HMLCPHOH_03540 0.0 yddE S AAA-like domain
HMLCPHOH_03541 2e-55 S Domain of unknown function (DUF1874)
HMLCPHOH_03542 0.0 yddG S maturation of SSU-rRNA
HMLCPHOH_03543 2.4e-189 yddH CBM50 M Lysozyme-like
HMLCPHOH_03544 8.7e-87 yddI
HMLCPHOH_03545 4.1e-65 S Domain of unknown function with cystatin-like fold (DUF4467)
HMLCPHOH_03546 9.5e-128 S TIR domain
HMLCPHOH_03547 1.4e-74 S response regulator aspartate phosphatase
HMLCPHOH_03549 3.4e-161
HMLCPHOH_03550 2.7e-188 luxA C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HMLCPHOH_03551 2.4e-71 lrpA K transcriptional
HMLCPHOH_03552 1.5e-77 lrpB K transcriptional
HMLCPHOH_03553 9.6e-100 yddQ 3.5.1.19 Q Isochorismatase family
HMLCPHOH_03554 1.5e-143 yddR S Zn-dependent hydrolases of the beta-lactamase fold
HMLCPHOH_03555 5e-227 ydeG EGP Major facilitator Superfamily
HMLCPHOH_03560 1.4e-112 ydeA 1.11.1.6, 3.5.1.124 S DJ-1/PfpI family
HMLCPHOH_03561 8.7e-30 cspL K Cold shock
HMLCPHOH_03562 6.1e-79 carD K Transcription factor
HMLCPHOH_03563 4.6e-35 ydzE EG spore germination
HMLCPHOH_03564 1.1e-166 rhaS5 K AraC-like ligand binding domain
HMLCPHOH_03565 2.3e-173 yicL EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
HMLCPHOH_03566 2.5e-166 ydeE K AraC family transcriptional regulator
HMLCPHOH_03567 2.2e-265 K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
HMLCPHOH_03568 3.4e-220 ydeG EGP Major facilitator superfamily
HMLCPHOH_03569 2.9e-47 ydeH
HMLCPHOH_03570 8.9e-107 ydeI S Bacteriocin-protection, YdeI or OmpD-Associated
HMLCPHOH_03571 4e-116
HMLCPHOH_03572 1.8e-153 ydeK EG -transporter
HMLCPHOH_03573 1.5e-274 ydeL K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
HMLCPHOH_03574 4.2e-74 maoC I N-terminal half of MaoC dehydratase
HMLCPHOH_03575 8.6e-107 ydeN S Serine hydrolase
HMLCPHOH_03576 1.1e-58 K HxlR-like helix-turn-helix
HMLCPHOH_03577 1.9e-153 yqfU S Uncharacterized protein conserved in bacteria (DUF2179)
HMLCPHOH_03578 4.8e-69 ydeP K Transcriptional regulator
HMLCPHOH_03579 1.6e-108 ydeQ S NADPH-quinone reductase (modulator of drug activity B)
HMLCPHOH_03580 1.2e-195 ydeR EGP Major facilitator Superfamily
HMLCPHOH_03581 8.4e-105 ydeS K Transcriptional regulator
HMLCPHOH_03582 1.3e-57 arsR K transcriptional
HMLCPHOH_03583 5.2e-232 arsB P Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HMLCPHOH_03584 7.2e-149 ydfB J GNAT acetyltransferase
HMLCPHOH_03585 1e-162 ydfC EG EamA-like transporter family
HMLCPHOH_03586 1.9e-275 ydfD K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
HMLCPHOH_03587 5.9e-117 ydfE S Flavin reductase like domain
HMLCPHOH_03588 2.7e-123 ydfF K helix_turn_helix, Arsenical Resistance Operon Repressor
HMLCPHOH_03589 1.5e-79 ydfG S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HMLCPHOH_03591 5.3e-180 ydfH 2.7.13.3 T Histidine kinase
HMLCPHOH_03592 1.4e-110 ydfI K Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HMLCPHOH_03593 0.0 ydfJ S drug exporters of the RND superfamily
HMLCPHOH_03594 1.9e-177 S Alpha/beta hydrolase family
HMLCPHOH_03595 5.9e-118 S Protein of unknown function (DUF554)
HMLCPHOH_03596 3.2e-147 K Bacterial transcription activator, effector binding domain
HMLCPHOH_03597 1.6e-155 fieF P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HMLCPHOH_03598 9.6e-112 ydfN C nitroreductase
HMLCPHOH_03599 3.6e-187 ydfO E COG0346 Lactoylglutathione lyase and related lyases
HMLCPHOH_03600 8.8e-63 mhqP S DoxX
HMLCPHOH_03601 1.3e-57 traF CO Thioredoxin
HMLCPHOH_03602 7.1e-15 ydgA S Spore germination protein gerPA/gerPF
HMLCPHOH_03603 6.3e-29
HMLCPHOH_03605 4.4e-118 ydfR S Protein of unknown function (DUF421)
HMLCPHOH_03606 5.2e-122 ydfS S Protein of unknown function (DUF421)
HMLCPHOH_03607 1.7e-75 cotP O Belongs to the small heat shock protein (HSP20) family
HMLCPHOH_03608 1.4e-37 ydgA S Spore germination protein gerPA/gerPF
HMLCPHOH_03609 1.3e-41 ydgB S Spore germination protein gerPA/gerPF
HMLCPHOH_03610 1.5e-101 K Bacterial regulatory proteins, tetR family
HMLCPHOH_03611 7.3e-53 S DoxX-like family
HMLCPHOH_03612 2.4e-86 yycN 2.3.1.128 K Acetyltransferase
HMLCPHOH_03613 4.2e-308 expZ S ABC transporter
HMLCPHOH_03614 4e-251 cycA E COG1113 Gamma-aminobutyrate permease and related permeases
HMLCPHOH_03615 4.6e-91 dinB S DinB family
HMLCPHOH_03616 4.7e-80 K helix_turn_helix multiple antibiotic resistance protein
HMLCPHOH_03617 0.0 ydgH S drug exporters of the RND superfamily
HMLCPHOH_03618 1e-113 drgA C nitroreductase
HMLCPHOH_03619 1.1e-69 ydgJ K Winged helix DNA-binding domain
HMLCPHOH_03620 2.5e-209 tcaB EGP Major facilitator Superfamily
HMLCPHOH_03621 1.2e-121 ydhB S membrane transporter protein
HMLCPHOH_03622 6.5e-122 ydhC K FCD
HMLCPHOH_03623 3.3e-244 ydhD M Glycosyl hydrolase
HMLCPHOH_03624 7e-228 ydhE CG COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase
HMLCPHOH_03625 1.9e-127
HMLCPHOH_03626 1.4e-259 phoB 3.1.3.1 P Belongs to the alkaline phosphatase family
HMLCPHOH_03627 4.6e-69 frataxin S Domain of unknown function (DU1801)
HMLCPHOH_03629 4.1e-86 K Acetyltransferase (GNAT) domain
HMLCPHOH_03630 1.8e-184 ydhJ S Metal dependent phosphohydrolases with conserved 'HD' motif.
HMLCPHOH_03631 1.7e-99 ydhK M Protein of unknown function (DUF1541)
HMLCPHOH_03632 4.6e-200 pbuE EGP Major facilitator Superfamily
HMLCPHOH_03633 1.1e-47 ydhM 2.7.1.196, 2.7.1.205 G phosphotransferase system
HMLCPHOH_03634 3.5e-52 ydhN3 2.7.1.196, 2.7.1.205 G phosphotransferase system
HMLCPHOH_03635 2e-239 celB G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HMLCPHOH_03636 2.4e-288 ydhP 3.2.1.21, 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
HMLCPHOH_03637 3.9e-133 ydhQ K UTRA
HMLCPHOH_03638 9.2e-172 gmuE 2.7.1.2, 2.7.1.4 GK COG1940 Transcriptional regulator sugar kinase
HMLCPHOH_03639 4.2e-191 manA 5.3.1.8 G mannose-6-phosphate isomerase
HMLCPHOH_03640 7.3e-216 gmuG 3.2.1.78 GH26 G Belongs to the glycosyl hydrolase 26 family
HMLCPHOH_03641 8.7e-78 ydhU P Catalase
HMLCPHOH_03642 1.1e-16 ydhU P Manganese containing catalase
HMLCPHOH_03645 1.3e-63 hxlR K transcriptional
HMLCPHOH_03646 3.3e-107 hxlA 4.1.2.43 G 3-hexulose-6-phosphate synthase
HMLCPHOH_03647 4.6e-97 hxlB 4.1.2.43, 5.3.1.27 G SIS domain
HMLCPHOH_03648 3e-187 tlpC 2.7.13.3 NT chemotaxis protein
HMLCPHOH_03649 3.2e-72 nucA M Deoxyribonuclease NucA/NucB
HMLCPHOH_03650 3.4e-70 nin S Competence protein J (ComJ)
HMLCPHOH_03651 1.2e-298 yckE 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
HMLCPHOH_03652 3.5e-52 yckD S Protein of unknown function (DUF2680)
HMLCPHOH_03653 3.3e-77 yckC S membrane
HMLCPHOH_03656 1.1e-132 yckB ET COG0834 ABC-type amino acid transport signal transduction systems, periplasmic component domain
HMLCPHOH_03657 2.4e-116 yecS P COG0765 ABC-type amino acid transport system, permease component
HMLCPHOH_03658 1.4e-228 yciC S GTPases (G3E family)
HMLCPHOH_03659 5.5e-109 yciB M ErfK YbiS YcfS YnhG
HMLCPHOH_03660 1.4e-172 folE2 3.5.4.16 S Converts GTP to 7,8-dihydroneopterin triphosphate
HMLCPHOH_03661 7.6e-222 nasA P COG2223 Nitrate nitrite transporter
HMLCPHOH_03662 0.0 nirB 1.7.1.15 C Assimilatory nitrate reductase (electron transfer subunit)
HMLCPHOH_03663 0.0 nasC C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HMLCPHOH_03664 0.0 nirB 1.7.1.15 C Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HMLCPHOH_03665 4.6e-57 nirD 1.7.1.15 P Nitrite reductase
HMLCPHOH_03666 9.3e-283 cobA 2.1.1.107, 4.2.1.75 H Belongs to the precorrin methyltransferase family
HMLCPHOH_03667 1.3e-193 ycgT 1.18.1.2, 1.19.1.1 C Ferredoxin--NADP reductase
HMLCPHOH_03668 5.7e-163 I alpha/beta hydrolase fold
HMLCPHOH_03669 1.2e-139 ycgR S permeases
HMLCPHOH_03670 2.6e-147 ycgQ S membrane
HMLCPHOH_03671 1.6e-227 ycgP QT COG2508 Regulator of polyketide synthase expression
HMLCPHOH_03672 9e-248 putP E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HMLCPHOH_03673 7.3e-294 rocA 1.2.1.88, 1.5.5.2 C Belongs to the aldehyde dehydrogenase family. RocA subfamily
HMLCPHOH_03674 5.1e-170 ycgM E Proline dehydrogenase
HMLCPHOH_03675 2.9e-145 ycgL S Predicted nucleotidyltransferase
HMLCPHOH_03676 2.9e-184 cah 3.1.1.41 Q Acetyl xylan esterase (AXE1)
HMLCPHOH_03677 2.2e-179 oxyR3 K LysR substrate binding domain
HMLCPHOH_03678 3.6e-145 yafE Q ubiE/COQ5 methyltransferase family
HMLCPHOH_03679 3e-104 aroK 2.7.1.71, 4.2.3.4 F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HMLCPHOH_03680 2.5e-109 tmrB S AAA domain
HMLCPHOH_03681 1.5e-149 nadE 6.3.1.5 H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
HMLCPHOH_03682 2.4e-112 ycgI S Domain of unknown function (DUF1989)
HMLCPHOH_03683 5.6e-250 ycgH E COG1113 Gamma-aminobutyrate permease and related permeases
HMLCPHOH_03684 1.2e-151 yqcI S YqcI/YcgG family
HMLCPHOH_03685 6.8e-113 ycgF E Lysine exporter protein LysE YggA
HMLCPHOH_03686 3.4e-77 emrR K helix_turn_helix multiple antibiotic resistance protein
HMLCPHOH_03687 6.2e-269 mdr EGP Major facilitator Superfamily
HMLCPHOH_03688 6.5e-293 lctP C L-lactate permease
HMLCPHOH_03689 3.3e-183 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
HMLCPHOH_03690 0.0 amyE 3.2.1.1 GH13 G alpha-amylase
HMLCPHOH_03691 1.1e-98 ycgB
HMLCPHOH_03692 8.7e-257 ycgA S Membrane
HMLCPHOH_03693 1.2e-219 amhX S amidohydrolase
HMLCPHOH_03694 5.3e-164 opuAC E glycine betaine
HMLCPHOH_03695 1.3e-127 opuAB P glycine betaine
HMLCPHOH_03696 5.1e-229 proV 3.6.3.32 E glycine betaine
HMLCPHOH_03697 1.6e-45 K helix_turn_helix, Arsenical Resistance Operon Repressor
HMLCPHOH_03698 1.9e-209 yceJ EGP Uncharacterised MFS-type transporter YbfB
HMLCPHOH_03699 1e-218 naiP P Uncharacterised MFS-type transporter YbfB
HMLCPHOH_03700 2e-192 yceH P Belongs to the TelA family
HMLCPHOH_03701 0.0 yceG S Putative component of 'biosynthetic module'
HMLCPHOH_03702 6.3e-137 terC P Protein of unknown function (DUF475)
HMLCPHOH_03703 4.6e-108 yceE T proteins involved in stress response, homologs of TerZ and
HMLCPHOH_03704 2.8e-105 yceD T proteins involved in stress response, homologs of TerZ and
HMLCPHOH_03705 3.9e-110 yceC 3.5.4.33 T proteins involved in stress response, homologs of TerZ and
HMLCPHOH_03706 5.4e-189 yceB C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HMLCPHOH_03707 1.7e-135 adcB P COG1108 ABC-type Mn2 Zn2 transport systems, permease components
HMLCPHOH_03708 2.5e-132 adcC P 'COG1121 ABC-type Mn Zn transport systems, ATPase component'
HMLCPHOH_03709 6.6e-168 adcA P Belongs to the bacterial solute-binding protein 9 family
HMLCPHOH_03710 0.0 ycdG 3.2.1.10 GH13 G COG0366 Glycosidases
HMLCPHOH_03711 1.6e-140 IQ Enoyl-(Acyl carrier protein) reductase
HMLCPHOH_03712 5.5e-174 S response regulator aspartate phosphatase
HMLCPHOH_03713 1.7e-95 cwlK M D-alanyl-D-alanine carboxypeptidase
HMLCPHOH_03714 6.7e-268 ycdC K Belongs to the sigma-70 factor family. ECF subfamily
HMLCPHOH_03715 5.9e-282 ycdB K Belongs to the sigma-70 factor family. ECF subfamily
HMLCPHOH_03716 6.6e-177 ycdA S Domain of unknown function (DUF5105)
HMLCPHOH_03717 1.6e-174 yccK C Aldo keto reductase
HMLCPHOH_03718 4.5e-203 natB CP ABC-2 family transporter protein
HMLCPHOH_03719 4.1e-133 natA 3.6.3.7 CP ATPases associated with a variety of cellular activities
HMLCPHOH_03720 1.2e-126 lytR_2 T LytTr DNA-binding domain
HMLCPHOH_03721 2e-161 2.7.13.3 T GHKL domain
HMLCPHOH_03722 9.5e-200 yccF K DNA-templated transcriptional preinitiation complex assembly
HMLCPHOH_03723 2e-59 S RDD family
HMLCPHOH_03724 5.6e-115 lip 3.1.1.3 S acetyltransferases and hydrolases with the alpha beta hydrolase fold
HMLCPHOH_03725 2.2e-202 ansB 3.5.1.1 EJ COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D
HMLCPHOH_03726 4.8e-102 yxaF K Transcriptional regulator
HMLCPHOH_03727 5.8e-229 lmrB EGP the major facilitator superfamily
HMLCPHOH_03728 6.2e-210 ycbU E Selenocysteine lyase
HMLCPHOH_03729 1.4e-121 pcp 3.4.19.3 O Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HMLCPHOH_03730 1.2e-124 tatC U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HMLCPHOH_03731 5e-28 tatA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
HMLCPHOH_03732 0.0 phoD 3.1.3.1 P COG3540 Phosphodiesterase alkaline phosphatase D
HMLCPHOH_03733 6.6e-136 ycbR T vWA found in TerF C terminus
HMLCPHOH_03734 1.3e-78 sleB 3.5.1.28 M Cell wall
HMLCPHOH_03735 8.2e-53 ycbP S Protein of unknown function (DUF2512)
HMLCPHOH_03736 2.1e-115 S ABC-2 family transporter protein
HMLCPHOH_03737 4.8e-168 ycbN V ABC transporter, ATP-binding protein
HMLCPHOH_03738 2.4e-170 T PhoQ Sensor
HMLCPHOH_03739 1.7e-125 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HMLCPHOH_03740 7.3e-172 eamA1 EG spore germination
HMLCPHOH_03741 4.4e-24 rtpA K Tryptophan RNA-binding attenuator protein inhibitory protein
HMLCPHOH_03742 1.2e-15 ycbJ S Macrolide 2'-phosphotransferase
HMLCPHOH_03743 4.2e-72 ycbJ S Macrolide 2'-phosphotransferase
HMLCPHOH_03744 3.7e-298 garD 4.2.1.42, 4.2.1.7 G Altronate
HMLCPHOH_03745 1.5e-124 ycbG K FCD
HMLCPHOH_03746 2.2e-270 gudD 4.2.1.40 M Belongs to the mandelate racemase muconate lactonizing enzyme family
HMLCPHOH_03747 1.2e-255 gudP G COG0477 Permeases of the major facilitator superfamily
HMLCPHOH_03748 3.7e-274 ycbD C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
HMLCPHOH_03749 2.7e-174 kdgD 4.2.1.41 EM 5-dehydro-4-deoxyglucarate dehydratase activity
HMLCPHOH_03750 9e-170 glnL T Regulator
HMLCPHOH_03751 1.5e-229 phoQ 2.7.13.3 T Histidine kinase
HMLCPHOH_03752 1.5e-188 glsA 3.5.1.2 E Belongs to the glutaminase family
HMLCPHOH_03753 2.3e-257 agcS E Sodium alanine symporter
HMLCPHOH_03754 9.3e-183 mmuM 1.5.1.20, 2.1.1.10 H homocysteine
HMLCPHOH_03755 6.7e-262 mmuP E amino acid
HMLCPHOH_03756 5.4e-203 ilvE 2.6.1.42 E Branched-chain amino acid aminotransferase
HMLCPHOH_03758 4.9e-128 K UTRA
HMLCPHOH_03759 2.1e-137 nagB 3.1.1.31, 3.5.99.6 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
HMLCPHOH_03760 0.0 ptsG 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
HMLCPHOH_03761 4.9e-216 gltP C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
HMLCPHOH_03762 3.9e-192 yceA S Belongs to the UPF0176 family
HMLCPHOH_03763 6.7e-167 ybfP K Transcriptional regulator
HMLCPHOH_03764 4.3e-258 S Erythromycin esterase
HMLCPHOH_03765 3.2e-46 ybfN
HMLCPHOH_03766 5.6e-149 psd 4.1.1.65 I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)
HMLCPHOH_03767 2.7e-85 ybfM S SNARE associated Golgi protein
HMLCPHOH_03768 3.2e-95 pssA 2.7.8.8 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HMLCPHOH_03769 2.5e-169 S Alpha/beta hydrolase family
HMLCPHOH_03771 6.9e-178 mpr 3.4.21.19 M Belongs to the peptidase S1B family
HMLCPHOH_03772 1.9e-214 purT 2.1.2.2 F Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HMLCPHOH_03773 2.3e-145 msmR K AraC-like ligand binding domain
HMLCPHOH_03774 8.8e-162 ybfH EG EamA-like transporter family
HMLCPHOH_03775 0.0 ybfG 3.2.1.132 M Domain of unknown function (DUF1906)
HMLCPHOH_03777 2.2e-224 ybfB G COG0477 Permeases of the major facilitator superfamily
HMLCPHOH_03778 1.6e-171 ybfA 3.4.15.5 K FR47-like protein
HMLCPHOH_03779 2.9e-35 S Protein of unknown function (DUF2651)
HMLCPHOH_03780 7.3e-258 glpT G -transporter
HMLCPHOH_03781 5.6e-166 glpQ 3.1.4.46 C glycerophosphoryl diester phosphodiesterase
HMLCPHOH_03782 2.3e-290 ybeC E amino acid
HMLCPHOH_03783 4.9e-41 ybyB
HMLCPHOH_03784 1.4e-247 cypC 1.11.2.4, 1.14.14.1 Q Cytochrome P450
HMLCPHOH_03785 7.2e-152 ybxI 3.5.2.6 V beta-lactamase
HMLCPHOH_03786 4.9e-30 ybxH S Family of unknown function (DUF5370)
HMLCPHOH_03787 3.7e-38 csgA S Sigma-G-dependent sporulation-specific SASP protein
HMLCPHOH_03788 2.4e-259 yifK E COG1113 Gamma-aminobutyrate permease and related permeases
HMLCPHOH_03789 1.5e-217 ybdO S Domain of unknown function (DUF4885)
HMLCPHOH_03790 4.8e-154 ybdN
HMLCPHOH_03791 1.6e-140 KLT Protein tyrosine kinase
HMLCPHOH_03793 1.8e-173 T His Kinase A (phospho-acceptor) domain
HMLCPHOH_03794 1.5e-123 T Transcriptional regulatory protein, C terminal
HMLCPHOH_03795 6.2e-182 S hydrolases or acyltransferases (alpha beta hydrolase superfamily)
HMLCPHOH_03796 9.6e-79 txn CO Thioredoxin-like
HMLCPHOH_03797 7.8e-91 C HEAT repeats
HMLCPHOH_03798 4e-248 skfF S ABC transporter
HMLCPHOH_03799 1.9e-135 skfE V ABC transporter
HMLCPHOH_03800 1.6e-277 V CAAX protease self-immunity
HMLCPHOH_03801 9.1e-239 J 4Fe-4S single cluster domain
HMLCPHOH_03803 2e-203 ybcL EGP Major facilitator Superfamily
HMLCPHOH_03804 5.1e-50 ybzH K Helix-turn-helix domain
HMLCPHOH_03805 4.7e-61 ybcI S Uncharacterized conserved protein (DUF2294)
HMLCPHOH_03806 3.9e-47
HMLCPHOH_03807 3.7e-96 can 4.2.1.1 P carbonic anhydrase
HMLCPHOH_03808 0.0 ybcC S Belongs to the UPF0753 family
HMLCPHOH_03809 1.5e-278 ndhF 1.6.5.3 CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit
HMLCPHOH_03810 5.1e-101 ogt 2.1.1.63, 3.2.2.21 L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HMLCPHOH_03811 1.4e-121 adaA 3.2.2.21 K Transcriptional regulator
HMLCPHOH_03812 2.1e-176 alkA 3.2.2.21 L COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HMLCPHOH_03813 0.0 glmS 2.6.1.16 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
HMLCPHOH_03814 9.3e-253 glmM 5.4.2.10 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HMLCPHOH_03815 3e-225 ybbR S protein conserved in bacteria
HMLCPHOH_03816 2.7e-146 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HMLCPHOH_03817 1.7e-103 rsiW K Is the anti-sigma factor for SigW. The presence of RsiW leads to the inactivation of SigW, and its proteolytic destruction to sigma-W activation
HMLCPHOH_03818 8.5e-99 sigW K Belongs to the sigma-70 factor family. ECF subfamily
HMLCPHOH_03824 3.9e-78 ybbK 2.4.2.1, 6.3.2.4 S Protein of unknown function (DUF523)
HMLCPHOH_03825 6.4e-87 ybbJ J acetyltransferase
HMLCPHOH_03826 2.1e-163 murQ 4.2.1.126 G Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HMLCPHOH_03827 1.1e-150 ybbH K transcriptional
HMLCPHOH_03828 9.8e-234 ybbF 2.7.1.193, 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G phosphotransferase system
HMLCPHOH_03829 4e-256 yfeW 3.4.16.4 V Belongs to the UPF0214 family
HMLCPHOH_03830 0.0 ybbD 3.2.1.52 G Belongs to the glycosyl hydrolase 3 family
HMLCPHOH_03831 4.4e-241 ybbC 3.2.1.52 S protein conserved in bacteria
HMLCPHOH_03832 5.4e-308 ybbB K COG2207 AraC-type DNA-binding domain-containing proteins
HMLCPHOH_03833 7.2e-167 feuA P Iron-uptake system-binding protein
HMLCPHOH_03834 1.1e-176 feuB P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMLCPHOH_03835 3e-179 feuC P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMLCPHOH_03836 2.2e-142 ybbA S Putative esterase
HMLCPHOH_03837 1.2e-161 ybaS 1.1.1.58 S Na -dependent transporter
HMLCPHOH_03839 4.6e-250 ybaR P COG0659 Sulfate permease and related transporters (MFS superfamily)
HMLCPHOH_03840 0.0 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HMLCPHOH_03841 0.0 gyrB 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HMLCPHOH_03842 1.8e-37 yaaB S Domain of unknown function (DUF370)
HMLCPHOH_03843 1.4e-206 recF L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HMLCPHOH_03844 2.4e-33 yaaA S S4 domain
HMLCPHOH_03845 6.1e-205 dnaN 2.7.7.7 L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
HMLCPHOH_03846 6e-252 dnaA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HMLCPHOH_03847 3e-54 rnpA 3.1.26.5 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
HMLCPHOH_03848 1.7e-118 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HMLCPHOH_03849 6.5e-108 jag S single-stranded nucleic acid binding R3H
HMLCPHOH_03850 3.7e-249 mnmE S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HMLCPHOH_03851 0.0 gidA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
HMLCPHOH_03852 1.4e-130 rsmG 2.1.1.170 J Specifically methylates the N7 position of guanine in position 535 of 16S rRNA
HMLCPHOH_03853 1.9e-150 noc D Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage
HMLCPHOH_03854 1.9e-74 S Bacterial PH domain
HMLCPHOH_03855 2.2e-134 soj D COG1192 ATPases involved in chromosome partitioning
HMLCPHOH_03856 2.1e-149 spo0J K Belongs to the ParB family
HMLCPHOH_03857 1.6e-111 yyaC S Sporulation protein YyaC
HMLCPHOH_03858 8.1e-177 yyaD S Membrane
HMLCPHOH_03859 2.3e-33 yyzM S protein conserved in bacteria
HMLCPHOH_03860 0.0 yyaE C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HMLCPHOH_03861 4e-201 ychF J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
HMLCPHOH_03862 4.3e-46 rpsF J Binds together with S18 to 16S ribosomal RNA
HMLCPHOH_03863 2.9e-69 ssb L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
HMLCPHOH_03864 5.1e-37 rpsR J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HMLCPHOH_03865 8.1e-145 xth 3.1.11.2 L exodeoxyribonuclease III
HMLCPHOH_03866 3.3e-180 ccpB 3.5.1.4, 5.1.1.1 K Transcriptional regulator
HMLCPHOH_03867 4e-68 yyaH 4.4.1.5 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HMLCPHOH_03868 5.1e-96 maa 2.3.1.79 S Bacterial transferase hexapeptide (six repeats)
HMLCPHOH_03869 3.8e-246 EGP Major facilitator superfamily
HMLCPHOH_03870 9.5e-169 yyaK S CAAX protease self-immunity
HMLCPHOH_03871 0.0 yyaL O COG1331 Highly conserved protein containing a thioredoxin domain
HMLCPHOH_03872 3.3e-161 yyaM EG EamA-like transporter family
HMLCPHOH_03873 5.1e-61 yyaN K MerR HTH family regulatory protein
HMLCPHOH_03874 9.7e-44 yyaL O Highly conserved protein containing a thioredoxin domain
HMLCPHOH_03875 1.7e-249 tetL EGP Major facilitator Superfamily
HMLCPHOH_03876 1.7e-107 yyaP 1.5.1.3 H RibD C-terminal domain
HMLCPHOH_03877 5.4e-67 yyaQ S YjbR
HMLCPHOH_03878 5.4e-100 yyaR K Acetyltransferase (GNAT) domain
HMLCPHOH_03879 1.5e-101 yyaS S Membrane
HMLCPHOH_03880 5.9e-79 yjcF S Acetyltransferase (GNAT) domain
HMLCPHOH_03881 5.6e-77 yybA 2.3.1.57 K transcriptional
HMLCPHOH_03882 3e-127 S Metallo-beta-lactamase superfamily
HMLCPHOH_03883 2.7e-77 yybC
HMLCPHOH_03884 2e-79 yjcF S Acetyltransferase (GNAT) domain
HMLCPHOH_03885 2.1e-165 yybE K Transcriptional regulator
HMLCPHOH_03886 3.2e-220 ynfM EGP Major facilitator Superfamily
HMLCPHOH_03887 3e-124 yybG S Pentapeptide repeat-containing protein
HMLCPHOH_03888 5.9e-67 yybH S SnoaL-like domain
HMLCPHOH_03889 6.2e-132
HMLCPHOH_03890 2.6e-115 V ATPases associated with a variety of cellular activities
HMLCPHOH_03891 2e-127 S Protein of unknown function (DUF2705)
HMLCPHOH_03892 9e-122
HMLCPHOH_03893 4.1e-125
HMLCPHOH_03894 1.3e-78 yybN S Protein of unknown function (DUF2712)
HMLCPHOH_03895 1e-16
HMLCPHOH_03896 2.3e-240 yybO G COG0477 Permeases of the major facilitator superfamily
HMLCPHOH_03898 1.3e-70
HMLCPHOH_03899 1.1e-164 ppaC 3.6.1.1 C Inorganic pyrophosphatase
HMLCPHOH_03900 1.4e-68 ydeP3 K Transcriptional regulator
HMLCPHOH_03901 3.9e-84 cotF M Spore coat protein
HMLCPHOH_03903 2.9e-160 yybS S membrane
HMLCPHOH_03904 0.0 yybT T signaling protein consisting of a modified GGDEF domain and a DHH domain
HMLCPHOH_03905 2.2e-73 rplI J binds to the 23S rRNA
HMLCPHOH_03906 0.0 yycA M COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HMLCPHOH_03907 8.4e-221 yeaN P COG2807 Cyanate permease
HMLCPHOH_03908 1.9e-15 yycC K YycC-like protein
HMLCPHOH_03910 1.9e-29 yycD S Uncharacterized protein conserved in bacteria (DUF2188)
HMLCPHOH_03911 3e-251 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
HMLCPHOH_03912 8e-78 yycE 3.4.21.26, 5.3.1.24 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HMLCPHOH_03913 1.7e-248 purA 6.3.4.4 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HMLCPHOH_03918 1.1e-132 T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HMLCPHOH_03919 0.0 vicK 2.7.13.3 T Histidine kinase
HMLCPHOH_03920 3.6e-260 yycH S protein conserved in bacteria
HMLCPHOH_03921 7.3e-155 yycI S protein conserved in bacteria
HMLCPHOH_03922 8.7e-150 vicX 3.1.26.11 S COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I
HMLCPHOH_03923 8.4e-221 htrA 3.4.21.107 O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HMLCPHOH_03924 1.5e-258 rocR KT COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains
HMLCPHOH_03925 1.7e-234 rocD 2.6.1.11, 2.6.1.13, 2.6.1.17 E Catalyzes the interconversion of ornithine to glutamate semialdehyde
HMLCPHOH_03926 9.7e-261 rocE E amino acid
HMLCPHOH_03927 2.3e-167 rocF 3.5.3.1, 3.5.3.11 E Belongs to the arginase family
HMLCPHOH_03929 5e-188 S aspartate phosphatase
HMLCPHOH_03930 3.1e-86 yycN 2.3.1.128 K Acetyltransferase
HMLCPHOH_03931 5.8e-132 yycO S Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HMLCPHOH_03932 1.6e-221 yycP
HMLCPHOH_03933 2.1e-33 yycQ S Protein of unknown function (DUF2651)
HMLCPHOH_03935 3e-234 fdhA 1.1.1.1, 1.1.1.14, 1.1.1.284, 1.2.1.46 E COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
HMLCPHOH_03936 4.2e-71
HMLCPHOH_03937 1.1e-09 S YyzF-like protein
HMLCPHOH_03938 5.2e-81 rlmH 2.1.1.177 J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HMLCPHOH_03939 7.3e-280 S Calcineurin-like phosphoesterase
HMLCPHOH_03940 3.5e-65
HMLCPHOH_03941 0.0 S Uncharacterised protein conserved in bacteria (DUF2326)
HMLCPHOH_03942 0.0 fbp 3.1.3.11 G Firmicute fructose-1,6-bisphosphatase
HMLCPHOH_03943 8e-12
HMLCPHOH_03944 7.7e-185 S Radical SAM superfamily
HMLCPHOH_03945 8.4e-134 yydH O Peptidase M50
HMLCPHOH_03946 1.8e-110 prrC P ABC transporter
HMLCPHOH_03947 3.3e-119 S ABC-2 family transporter protein
HMLCPHOH_03948 7.6e-13
HMLCPHOH_03949 1.3e-128 yydK K Transcriptional regulator
HMLCPHOH_03950 2.3e-34 2.7.1.199 G phosphoenolpyruvate-dependent sugar phosphotransferase system
HMLCPHOH_03951 6.4e-292 bglA 3.2.1.86 GT1 G Belongs to the glycosyl hydrolase 1 family
HMLCPHOH_03952 3.8e-287 ahpF O Alkyl hydroperoxide reductase
HMLCPHOH_03953 2.1e-105 ahpC 1.11.1.15 O Alkyl hydroperoxide reductase
HMLCPHOH_03954 3.8e-273 gnd 1.1.1.343, 1.1.1.44 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HMLCPHOH_03955 4.5e-231 gntP EG COG2610 H gluconate symporter and related permeases
HMLCPHOH_03956 4.6e-304 gntK 2.7.1.12, 2.7.1.17, 2.7.1.5 G Belongs to the FGGY kinase family
HMLCPHOH_03957 7.3e-127 gntR K transcriptional
HMLCPHOH_03958 7e-209 glxK 2.7.1.165 G Belongs to the glycerate kinase type-1 family
HMLCPHOH_03959 1.3e-193 yxaB GM Polysaccharide pyruvyl transferase
HMLCPHOH_03960 2.6e-118 yxaC M effector of murein hydrolase
HMLCPHOH_03961 5.2e-50 S LrgA family
HMLCPHOH_03962 4.4e-71 yxaD K helix_turn_helix multiple antibiotic resistance protein
HMLCPHOH_03963 2.3e-201 IQ Belongs to the short-chain dehydrogenases reductases (SDR) family
HMLCPHOH_03964 7.1e-101 yxaF K Transcriptional regulator
HMLCPHOH_03965 1.5e-199 yxaG 1.13.11.24 S AraC-like ligand binding domain
HMLCPHOH_03966 1.4e-228 P Protein of unknown function (DUF418)
HMLCPHOH_03967 1.1e-75 yxaI S membrane protein domain
HMLCPHOH_03968 3.5e-65 S Family of unknown function (DUF5391)
HMLCPHOH_03969 6.8e-93 S PQQ-like domain
HMLCPHOH_03970 7.6e-214 yxaM U MFS_1 like family
HMLCPHOH_03971 0.0 asnB 6.3.5.4 E Asparagine synthase
HMLCPHOH_03972 1.1e-86 yxnB
HMLCPHOH_03973 4.9e-44 S Coenzyme PQQ synthesis protein D (PqqD)
HMLCPHOH_03974 3.3e-127 yxbB Q Met-10+ like-protein
HMLCPHOH_03975 1.2e-140 pdaB 3.5.1.104 G Polysaccharide deacetylase
HMLCPHOH_03976 1.3e-102 kbaA 2.7.8.43 S Involved in the activation of the KinB signaling pathway of sporulation
HMLCPHOH_03977 1.2e-84 gerD
HMLCPHOH_03978 1.4e-198 mrp D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP
HMLCPHOH_03979 1.1e-132 cwlD 3.5.1.28 M n-acetylmuramoyl-L-alanine amidase
HMLCPHOH_03980 9.7e-66 ybaK S Protein of unknown function (DUF2521)
HMLCPHOH_03981 8.2e-145 ybaJ Q Methyltransferase domain
HMLCPHOH_03982 4.7e-64 rpsI J Belongs to the universal ribosomal protein uS9 family
HMLCPHOH_03983 6.4e-78 rplM J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HMLCPHOH_03984 2.8e-142 truA 5.4.99.12 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
HMLCPHOH_03985 4.7e-119 ecfT P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HMLCPHOH_03986 1.7e-154 ecfA2 3.6.3.55 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HMLCPHOH_03987 5.1e-156 cbiO P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HMLCPHOH_03988 3.6e-58 rplQ J Ribosomal protein L17
HMLCPHOH_03989 3.1e-170 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HMLCPHOH_03990 2.1e-64 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HMLCPHOH_03991 3.1e-57 rpsM J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HMLCPHOH_03992 4.2e-13 rpmJ J Belongs to the bacterial ribosomal protein bL36 family
HMLCPHOH_03993 1.1e-33 infA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HMLCPHOH_03994 3.7e-142 map 3.4.11.18 E Methionine aminopeptidase
HMLCPHOH_03995 5.7e-123 adk 2.7.4.3 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
HMLCPHOH_03996 4.2e-234 secY U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
HMLCPHOH_03997 1.8e-72 rplO J binds to the 23S rRNA
HMLCPHOH_03998 1.9e-23 rpmD J Ribosomal protein L30
HMLCPHOH_03999 3.1e-84 rpsE J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HMLCPHOH_04000 4e-57 rplR J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HMLCPHOH_04001 1.3e-93 rplF J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HMLCPHOH_04002 3.9e-66 rpsH J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HMLCPHOH_04003 3.4e-28 rpsN J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HMLCPHOH_04004 4.6e-94 rplE J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HMLCPHOH_04005 6.2e-51 rplX J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HMLCPHOH_04006 3.9e-60 rplN J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HMLCPHOH_04007 3.5e-39 rpsQ J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HMLCPHOH_04008 1.7e-25 rpmC J Belongs to the universal ribosomal protein uL29 family
HMLCPHOH_04009 1.3e-75 rplP J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HMLCPHOH_04010 6.2e-117 rpsC J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HMLCPHOH_04011 4.3e-53 rplV J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HMLCPHOH_04012 3.7e-47 rpsS J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HMLCPHOH_04013 1.5e-155 rplB J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HMLCPHOH_04014 1.2e-43 rplW J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
HMLCPHOH_04015 3e-105 rplD J Forms part of the polypeptide exit tunnel
HMLCPHOH_04016 6.3e-111 rplC J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HMLCPHOH_04017 7.5e-49 rpsJ J Involved in the binding of tRNA to the ribosomes
HMLCPHOH_04018 9.1e-186 ybaC 3.4.11.5 S Alpha/beta hydrolase family
HMLCPHOH_04019 2.5e-225 tuf J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HMLCPHOH_04020 0.0 fusA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HMLCPHOH_04021 6e-82 rpsG J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
HMLCPHOH_04022 8.5e-72 rpsL J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HMLCPHOH_04023 8e-33 ybxF J Belongs to the eukaryotic ribosomal protein eL8 family
HMLCPHOH_04024 0.0 rpoC 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HMLCPHOH_04025 0.0 rpoB 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HMLCPHOH_04026 8.2e-108 rsmC 2.1.1.172 J Methyltransferase
HMLCPHOH_04027 1.3e-42 rplL J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
HMLCPHOH_04028 5.1e-79 rplJ J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HMLCPHOH_04029 1.1e-124 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
HMLCPHOH_04030 2.8e-70 rplK J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HMLCPHOH_04031 5.2e-96 nusG K Participates in transcription elongation, termination and antitermination
HMLCPHOH_04032 1e-21 secE U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
HMLCPHOH_04033 4.4e-115 sigH K Belongs to the sigma-70 factor family
HMLCPHOH_04034 1.2e-88 yacP S RNA-binding protein containing a PIN domain
HMLCPHOH_04035 1.2e-135 trmH 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HMLCPHOH_04036 1e-72 mrnC J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HMLCPHOH_04037 4.9e-273 cysS 6.1.1.16, 6.3.1.13 J Belongs to the class-I aminoacyl-tRNA synthetase family
HMLCPHOH_04038 7.2e-118 cysE 2.3.1.30 E Serine acetyltransferase
HMLCPHOH_04039 1.9e-280 gltX 6.1.1.17, 6.1.1.24 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HMLCPHOH_04040 3.1e-86 ispF 2.1.1.228, 2.7.7.60, 4.6.1.12 I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)
HMLCPHOH_04041 3.8e-125 ispD 2.7.7.60, 4.6.1.12 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)
HMLCPHOH_04042 2.7e-197 yacL S COG4956 Integral membrane protein (PIN domain superfamily)
HMLCPHOH_04043 1.3e-196 disA 2.7.7.85 L Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HMLCPHOH_04044 9.6e-256 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HMLCPHOH_04045 0.0 clpC O Belongs to the ClpA ClpB family
HMLCPHOH_04046 6.1e-202 mcsB 2.7.14.1, 2.7.3.2, 2.7.3.3 E Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity
HMLCPHOH_04047 4.7e-47 mcsA 2.7.14.1 S protein with conserved CXXC pairs
HMLCPHOH_04048 2.9e-76 ctsR K Belongs to the CtsR family
HMLCPHOH_04049 3.4e-31 csfB S Inhibitor of sigma-G Gin
HMLCPHOH_04050 4.7e-103 xpaC S 5-bromo-4-chloroindolyl phosphate hydrolysis protein
HMLCPHOH_04051 4.5e-203 yaaN P Belongs to the TelA family
HMLCPHOH_04052 1.1e-275 adiA 4.1.1.17, 4.1.1.18, 4.1.1.19 E Orn Lys Arg decarboxylase
HMLCPHOH_04053 3.6e-114 tmk 2.7.4.9 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HMLCPHOH_04054 2.2e-54 yaaQ S protein conserved in bacteria
HMLCPHOH_04055 1.5e-71 yaaR S protein conserved in bacteria
HMLCPHOH_04056 2.2e-182 holB 2.7.7.7 L DNA polymerase III
HMLCPHOH_04057 2.1e-146 yaaT S stage 0 sporulation protein
HMLCPHOH_04058 4.8e-31 yabA L Involved in initiation control of chromosome replication
HMLCPHOH_04059 2.5e-138 yabB 2.1.1.223 S Conserved hypothetical protein 95
HMLCPHOH_04060 1.5e-49 yazA L endonuclease containing a URI domain
HMLCPHOH_04061 4.3e-158 rsmI 2.1.1.198 H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HMLCPHOH_04062 8.8e-44 abrB K COG2002 Regulators of stationary sporulation gene expression
HMLCPHOH_04063 0.0 metG 6.1.1.10, 6.1.1.20 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HMLCPHOH_04064 1.8e-144 tatD L hydrolase, TatD
HMLCPHOH_04065 4.3e-194 rpfB GH23 T protein conserved in bacteria
HMLCPHOH_04066 8.4e-99 rnmV 3.1.26.8 J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HMLCPHOH_04067 2.4e-156 ksgA 2.1.1.182 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
HMLCPHOH_04068 1.6e-136 yabG S peptidase
HMLCPHOH_04069 7.8e-39 veg S protein conserved in bacteria
HMLCPHOH_04070 8.3e-27 sspF S DNA topological change
HMLCPHOH_04071 4.1e-161 ispE 2.1.1.182, 2.7.1.148 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HMLCPHOH_04072 2.6e-152 purR 2.4.2.22, 2.4.2.7 F pur operon repressor
HMLCPHOH_04073 3.8e-63 yabJ 3.5.99.10 J translation initiation inhibitor, yjgF family
HMLCPHOH_04074 4.6e-48 spoVG D Essential for sporulation. Interferes with or is a negative regulator of the pathway leading to asymmetric septation
HMLCPHOH_04075 6.6e-230 glmU 2.3.1.157, 2.7.7.23 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HMLCPHOH_04076 9.4e-175 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HMLCPHOH_04077 3.9e-97 ctc J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HMLCPHOH_04078 8e-105 pth 3.1.1.29 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
HMLCPHOH_04079 2.4e-39 yabK S Peptide ABC transporter permease
HMLCPHOH_04080 0.0 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HMLCPHOH_04081 1.5e-92 spoVT K stage V sporulation protein
HMLCPHOH_04082 2.4e-287 yabM S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
HMLCPHOH_04083 2.7e-245 mazG 3.6.1.66, 3.6.1.9 S COG3956 Protein containing tetrapyrrole methyltransferase domain and MazG-like
HMLCPHOH_04084 1.1e-37 yabO J COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
HMLCPHOH_04085 1.5e-49 yabP S Sporulation protein YabP
HMLCPHOH_04086 3.9e-108 yabQ S spore cortex biosynthesis protein
HMLCPHOH_04087 1.1e-44 divIC D Septum formation initiator
HMLCPHOH_04088 8.5e-58 yabR J RNA binding protein (contains ribosomal protein S1 domain)
HMLCPHOH_04091 0.0 spoIIE 3.1.3.16, 3.1.3.3 KT stage II sporulation protein E
HMLCPHOH_04092 1.5e-124 yabS S protein containing a von Willebrand factor type A (vWA) domain
HMLCPHOH_04093 6.7e-187 KLT serine threonine protein kinase
HMLCPHOH_04094 3.5e-274 tilS 2.4.2.8, 6.3.4.19 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
HMLCPHOH_04095 7.9e-94 hpt 2.4.2.8, 6.3.4.19 F Belongs to the purine pyrimidine phosphoribosyltransferase family
HMLCPHOH_04096 0.0 ftsH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HMLCPHOH_04097 1.5e-146 coaX 2.7.1.33 F Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HMLCPHOH_04098 2.9e-162 hslO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HMLCPHOH_04099 3.1e-153 yacD 5.2.1.8 O peptidyl-prolyl isomerase
HMLCPHOH_04100 8.9e-170 cysK 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
HMLCPHOH_04101 4.7e-271 pabB 2.6.1.85 EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HMLCPHOH_04102 1.5e-106 pabA 2.6.1.85, 4.1.3.27 EH Anthranilate synthase
HMLCPHOH_04103 1.6e-168 pabC 2.6.1.42, 4.1.3.38 EH 4-amino-4-deoxychorismate lyase
HMLCPHOH_04104 2.6e-160 folP 2.5.1.15, 2.7.6.3 H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HMLCPHOH_04105 8.2e-63 folB 1.13.11.81, 2.5.1.15, 2.7.6.3, 4.1.2.25, 5.1.99.8 H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HMLCPHOH_04106 2.7e-88 folK 1.13.11.81, 2.5.1.15, 2.7.6.3, 3.5.4.16, 4.1.2.25, 5.1.99.8 H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HMLCPHOH_04107 4.1e-30 yazB K transcriptional
HMLCPHOH_04108 3.7e-190 dus J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HMLCPHOH_04109 1.3e-287 lysS 6.1.1.6 J Belongs to the class-II aminoacyl-tRNA synthetase family
HMLCPHOH_04113 2e-08
HMLCPHOH_04114 1.4e-09 lexA 3.4.21.88 K LexA DNA binding domain
HMLCPHOH_04115 9.6e-09
HMLCPHOH_04116 3e-35 S YolD-like protein
HMLCPHOH_04118 1.1e-156 S Aspartate phosphatase response regulator
HMLCPHOH_04119 6.2e-185 A Pre-toxin TG
HMLCPHOH_04120 1.7e-39
HMLCPHOH_04121 1e-123 xlyA 3.5.1.28 M N-acetylmuramoyl-L-alanine amidase
HMLCPHOH_04122 7.9e-31 xhlB S SPP1 phage holin
HMLCPHOH_04123 2.8e-34 xhlA S Haemolysin XhlA
HMLCPHOH_04124 4.9e-149 xepA
HMLCPHOH_04125 6.7e-20
HMLCPHOH_04126 1.8e-43 xkdW S XkdW protein
HMLCPHOH_04127 5.2e-163
HMLCPHOH_04128 2.5e-35
HMLCPHOH_04129 6.7e-99 xkdU S Uncharacterised protein conserved in bacteria (DUF2313)
HMLCPHOH_04130 5.5e-184 xkdT S Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
HMLCPHOH_04131 2.5e-66 xkdS S Protein of unknown function (DUF2634)
HMLCPHOH_04132 1e-30 xkdR S Protein of unknown function (DUF2577)
HMLCPHOH_04133 7.2e-178 yqbQ 3.2.1.96 G NLP P60 protein
HMLCPHOH_04134 4.3e-110 xkdP S Lysin motif
HMLCPHOH_04135 0.0 xkdO L Transglycosylase SLT domain
HMLCPHOH_04136 5.5e-16
HMLCPHOH_04137 2.3e-67 S Phage XkdN-like tail assembly chaperone protein, TAC
HMLCPHOH_04138 7.4e-74 xkdM S Phage tail tube protein
HMLCPHOH_04139 1.2e-242 xkdK S Phage tail sheath C-terminal domain
HMLCPHOH_04140 2e-23
HMLCPHOH_04141 4.3e-66
HMLCPHOH_04142 3.1e-84 S Bacteriophage HK97-gp10, putative tail-component
HMLCPHOH_04143 4.4e-56 yqbH S Domain of unknown function (DUF3599)
HMLCPHOH_04144 1.5e-46 S Protein of unknown function (DUF3199)
HMLCPHOH_04145 2.1e-22 S YqbF, hypothetical protein domain
HMLCPHOH_04146 1.1e-146 xkdG S Phage capsid family
HMLCPHOH_04147 1.8e-95 yqbD 2.1.1.72 L Putative phage serine protease XkdF
HMLCPHOH_04149 2.2e-144 S Phage Mu protein F like protein
HMLCPHOH_04150 2.2e-250 yqbA S portal protein
HMLCPHOH_04151 7.2e-234 S phage terminase, large subunit
HMLCPHOH_04152 7.9e-75
HMLCPHOH_04153 1.8e-21
HMLCPHOH_04154 4.1e-08
HMLCPHOH_04155 1.2e-135 S helicase activity
HMLCPHOH_04160 1.5e-38
HMLCPHOH_04161 9.4e-19
HMLCPHOH_04164 3.2e-30
HMLCPHOH_04167 5.1e-69
HMLCPHOH_04168 1.3e-57 rusA L Endodeoxyribonuclease RusA
HMLCPHOH_04171 2.9e-150 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
HMLCPHOH_04173 2.8e-28 L primosome component and related proteins
HMLCPHOH_04175 4.9e-104 S Metallo-beta-lactamase superfamily
HMLCPHOH_04176 8e-112 recT L RecT family
HMLCPHOH_04178 1.9e-177 D nuclear chromosome segregation
HMLCPHOH_04182 1.5e-44
HMLCPHOH_04183 1.4e-13 S Helix-turn-helix domain
HMLCPHOH_04184 4.8e-14 K Helix-turn-helix XRE-family like proteins
HMLCPHOH_04185 5.2e-48 bldD K domain, Protein
HMLCPHOH_04186 1.4e-14
HMLCPHOH_04187 1.6e-35 xkdA E IrrE N-terminal-like domain
HMLCPHOH_04188 4.4e-81 L Phage integrase, N-terminal SAM-like domain
HMLCPHOH_04191 1.4e-100 yqaB E IrrE N-terminal-like domain
HMLCPHOH_04192 1e-101 adk 2.7.4.3 F adenylate kinase activity
HMLCPHOH_04194 1.1e-56 K sequence-specific DNA binding
HMLCPHOH_04195 6.5e-37 K Helix-turn-helix XRE-family like proteins
HMLCPHOH_04197 1.2e-103
HMLCPHOH_04201 1.5e-180 yqaJ L YqaJ-like viral recombinase domain
HMLCPHOH_04202 2.5e-155 recT L RecT family
HMLCPHOH_04203 1e-122 3.1.3.16 L DnaD domain protein
HMLCPHOH_04204 5.9e-168 xkdC L IstB-like ATP binding protein
HMLCPHOH_04206 7.2e-74 rusA L Endodeoxyribonuclease RusA
HMLCPHOH_04207 2.1e-31 yqaO S Phage-like element PBSX protein XtrA
HMLCPHOH_04208 1.6e-166
HMLCPHOH_04209 6.5e-81 L Transposase
HMLCPHOH_04211 6.3e-107 yqaS L DNA packaging
HMLCPHOH_04212 2.4e-253 S phage terminase, large subunit
HMLCPHOH_04213 5.9e-296 yqbA S portal protein
HMLCPHOH_04214 5.7e-169 S Phage Mu protein F like protein
HMLCPHOH_04215 2e-115
HMLCPHOH_04216 5.1e-128 yqbD 2.1.1.72 L Putative phage serine protease XkdF
HMLCPHOH_04217 1.9e-167 xkdG S Phage capsid family
HMLCPHOH_04218 3.6e-51 S YqbF, hypothetical protein domain
HMLCPHOH_04219 2.1e-67 S Protein of unknown function (DUF3199)
HMLCPHOH_04220 6.7e-65 yqbH S Domain of unknown function (DUF3599)
HMLCPHOH_04221 4.3e-94 S Bacteriophage HK97-gp10, putative tail-component
HMLCPHOH_04222 1.4e-77
HMLCPHOH_04223 3.2e-26
HMLCPHOH_04224 5.5e-256 xkdK S Phage tail sheath C-terminal domain
HMLCPHOH_04225 3.6e-76 xkdM S Phage tail tube protein
HMLCPHOH_04227 1.8e-67 S Phage XkdN-like tail assembly chaperone protein, TAC
HMLCPHOH_04228 0.0 xkdO L Transglycosylase SLT domain
HMLCPHOH_04229 9e-114 xkdP S Lysin motif
HMLCPHOH_04230 2.4e-181 yqbQ 3.2.1.96 G NLP P60 protein
HMLCPHOH_04231 1.8e-38 xkdR S Protein of unknown function (DUF2577)
HMLCPHOH_04232 9.6e-71 xkdS S Protein of unknown function (DUF2634)
HMLCPHOH_04233 6e-191 xkdT S Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
HMLCPHOH_04234 9.9e-103 xkdU S Uncharacterised protein conserved in bacteria (DUF2313)
HMLCPHOH_04235 9.6e-40
HMLCPHOH_04236 2e-221
HMLCPHOH_04237 4.1e-56 xkdW S XkdW protein
HMLCPHOH_04238 1.3e-23
HMLCPHOH_04239 4.8e-165 xepA
HMLCPHOH_04240 2.6e-68 S Bacteriophage holin family
HMLCPHOH_04241 1.1e-144 xlyA 3.5.1.28 M N-acetylmuramoyl-L-alanine amidase
HMLCPHOH_04243 5e-60
HMLCPHOH_04245 1.1e-104 S Suppressor of fused protein (SUFU)
HMLCPHOH_04246 1.1e-276 A Pre-toxin TG
HMLCPHOH_04249 1.6e-96 S Tetratricopeptide repeat
HMLCPHOH_04250 1.1e-152 yqcI S YqcI/YcgG family
HMLCPHOH_04251 1.6e-54 arsR K ArsR family transcriptional regulator
HMLCPHOH_04252 2.8e-73 cadI 4.4.1.5 E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HMLCPHOH_04253 6e-183 arsB 1.20.4.1 P Arsenic resistance protein
HMLCPHOH_04254 1.8e-77 arsC 1.20.4.1 T Catalyzes the reduction of arsenate As(V) to arsenite As(III)
HMLCPHOH_04255 1.4e-281 cisA2 L Recombinase
HMLCPHOH_04256 2.7e-182 yaaC S YaaC-like Protein
HMLCPHOH_04257 1.8e-273 guaB 1.1.1.205 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
HMLCPHOH_04258 5.2e-248 dacA 3.4.16.4 M Belongs to the peptidase S11 family
HMLCPHOH_04259 2.2e-157 pdxS 4.3.3.6 H Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HMLCPHOH_04260 8e-108 pdxT 4.3.3.6 H Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HMLCPHOH_04261 4.3e-207 serS 6.1.1.11 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HMLCPHOH_04262 1.3e-09
HMLCPHOH_04263 2.2e-122 dck 2.7.1.113, 2.7.1.74, 2.7.1.76 F Deoxycytidine kinase
HMLCPHOH_04264 3.2e-115 dgk 2.7.1.113, 2.7.1.74, 2.7.1.76 F Deoxyguanosine kinase
HMLCPHOH_04265 5.6e-215 yaaH M Glycoside Hydrolase Family
HMLCPHOH_04266 2.4e-98 yaaI Q COG1335 Amidases related to nicotinamidase
HMLCPHOH_04267 1e-84 tadA 3.5.4.1, 3.5.4.3, 3.5.4.33 FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
HMLCPHOH_04268 0.0 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HMLCPHOH_04269 5.3e-37 yaaK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HMLCPHOH_04270 3.9e-110 recR L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HMLCPHOH_04271 7.9e-32 yaaL S Protein of unknown function (DUF2508)
HMLCPHOH_04272 3.7e-36 bofA S Sigma-K factor-processing regulatory protein BofA
HMLCPHOH_04273 6.7e-270 srfAA Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HMLCPHOH_04274 3.4e-39 S COG NOG14552 non supervised orthologous group
HMLCPHOH_04279 2e-08
HMLCPHOH_04284 1.9e-33 accC 6.3.4.14, 6.4.1.2 I Biotin carboxylase, N-terminal domain
HMLCPHOH_04285 1.1e-52 M PFAM Lytic transglycosylase catalytic
HMLCPHOH_04286 3.8e-47 glnA 5.4.4.3, 6.3.1.2 E glutamine synthetase

eggNOG-mapper v2 (Database: eggNOG v5.0, Jul. 2018 release)