ORF_ID e_value Gene_name EC_number CAZy COGs Description
COIBCLKI_00001 7.9e-163 rpoC 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
COIBCLKI_00002 1.5e-67 S cog cog4699
COIBCLKI_00003 7.1e-175 comGA NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
COIBCLKI_00004 5.7e-144 cglB U protein transport across the cell outer membrane
COIBCLKI_00005 2.2e-43 comGC U Required for transformation and DNA binding
COIBCLKI_00006 6.4e-70 cglD NU Competence protein
COIBCLKI_00007 3.1e-15 NU Type II secretory pathway pseudopilin
COIBCLKI_00008 5.3e-72 comGF U Competence protein ComGF
COIBCLKI_00009 5.8e-12 comGF U Putative Competence protein ComGF
COIBCLKI_00010 7.7e-177 ytxK 2.1.1.72 L DNA methylase
COIBCLKI_00011 2.9e-221 ackA 2.7.2.1 F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
COIBCLKI_00012 8.8e-27 lanR K sequence-specific DNA binding
COIBCLKI_00013 2.5e-110 V CAAX protease self-immunity
COIBCLKI_00015 2.7e-112 S CAAX amino terminal protease family protein
COIBCLKI_00016 6.1e-132 proC 1.5.1.2 E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
COIBCLKI_00017 4.8e-204 pepA 3.4.11.7 G COG1363 Cellulase M and related proteins
COIBCLKI_00018 2e-08 XK27_10305 S Domain of unknown function (DUF4651)
COIBCLKI_00019 9.4e-55 ytpP 2.7.1.180, 5.3.4.1 CO Thioredoxin
COIBCLKI_00020 7.6e-09 S NTF2 fold immunity protein
COIBCLKI_00021 5.1e-113 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
COIBCLKI_00022 4.7e-120 S CAAX protease self-immunity
COIBCLKI_00023 5.1e-66 ssb_2 L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
COIBCLKI_00024 1e-90 tadA 3.5.4.1, 3.5.4.33 FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
COIBCLKI_00028 1.2e-160 rrmA 2.1.1.187 Q methyltransferase
COIBCLKI_00029 5.9e-140 S HAD hydrolase, family IA, variant
COIBCLKI_00030 5.3e-58 dapD 2.3.1.117, 2.3.1.89 E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
COIBCLKI_00031 1.1e-219 hipO 3.5.1.47 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
COIBCLKI_00032 2.8e-96 ygfA 6.3.3.2 H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
COIBCLKI_00033 1.2e-115 gluP 3.4.21.105 O membrane protein (homolog of Drosophila rhomboid)
COIBCLKI_00034 6.1e-171 galU 2.7.7.9 M UTP-glucose-1-phosphate uridylyltransferase
COIBCLKI_00035 3.7e-185 gpsA 1.1.1.94 I Glycerol-3-phosphate dehydrogenase
COIBCLKI_00036 3.9e-96 XK27_08585 S Psort location CytoplasmicMembrane, score
COIBCLKI_00037 4.8e-140 fnt P Formate nitrite transporter
COIBCLKI_00038 7.9e-230 XK27_09615 C reductase
COIBCLKI_00039 6.3e-108 XK27_09620 S FMN reductase (NADPH) activity
COIBCLKI_00040 2e-79 dut 3.6.1.23, 4.1.1.36, 6.3.2.5 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
COIBCLKI_00041 3.3e-73 3.5.1.19 Q hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
COIBCLKI_00042 1.8e-226 radA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
COIBCLKI_00043 7e-127 WQ51_05710 S Mitochondrial biogenesis AIM24
COIBCLKI_00044 1e-87 cah 4.2.1.1 P Reversible hydration of carbon dioxide
COIBCLKI_00045 1.2e-50 S Protein of unknown function (DUF3397)
COIBCLKI_00046 3.7e-70 rplK J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
COIBCLKI_00047 1.4e-119 rplA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
COIBCLKI_00048 0.0 dex 3.2.1.11 GH66 G Glycosyl hydrolase family 66
COIBCLKI_00049 8.7e-237 ilvA 4.3.1.19 E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
COIBCLKI_00050 3.3e-112 def 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
COIBCLKI_00051 4.9e-111 fnr5 K Catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
COIBCLKI_00052 1.3e-194 yhjX P Major Facilitator
COIBCLKI_00053 9.2e-43 rpsO J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
COIBCLKI_00054 9.5e-85 V VanZ like family
COIBCLKI_00055 6.6e-183 D nuclear chromosome segregation
COIBCLKI_00056 2.2e-123 glnQ E abc transporter atp-binding protein
COIBCLKI_00057 6.9e-276 glnP P ABC transporter
COIBCLKI_00058 1.5e-152 uppP 3.6.1.27 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
COIBCLKI_00059 8.3e-18 S Protein of unknown function (DUF3021)
COIBCLKI_00060 2.3e-128 mecA NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
COIBCLKI_00061 1e-183 tagO 2.7.8.33, 2.7.8.35 M transferase
COIBCLKI_00062 1.7e-137 sufC O ABC-type transport system involved in Fe-S cluster assembly, ATPase component
COIBCLKI_00063 6.3e-235 sufD O assembly protein SufD
COIBCLKI_00064 1.7e-237 sufS 2.8.1.7, 4.4.1.16 E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
COIBCLKI_00065 2.3e-72 nifU C SUF system FeS assembly protein, NifU family
COIBCLKI_00066 9.2e-33 blpT
COIBCLKI_00067 1e-145 V 'abc transporter, ATP-binding protein
COIBCLKI_00069 1.7e-188 pepP 3.4.11.9, 3.4.13.9 E Belongs to the peptidase M24B family
COIBCLKI_00070 3.3e-85 comEB 3.5.4.12 F ComE operon protein 2
COIBCLKI_00071 1.2e-97 efp J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
COIBCLKI_00072 1.7e-61 yqhY S protein conserved in bacteria
COIBCLKI_00073 8.1e-73 nusB K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
COIBCLKI_00074 9.2e-178 scrR K purine nucleotide biosynthetic process
COIBCLKI_00075 4.4e-285 scrB 3.2.1.26 GH32 G invertase
COIBCLKI_00076 0.0 scrA 2.7.1.201, 2.7.1.208, 2.7.1.211 G pts system
COIBCLKI_00077 1.8e-172 scrK 2.7.1.2, 2.7.1.4 GK Fructokinase
COIBCLKI_00078 5.6e-188 manA 5.3.1.8 G mannose-6-phosphate isomerase
COIBCLKI_00080 0.0 secA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
COIBCLKI_00081 3.3e-197 aroF 2.5.1.54 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
COIBCLKI_00082 6.2e-207 aroF 2.5.1.54 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
COIBCLKI_00083 3.4e-61 acpS 2.7.6.3, 2.7.8.7, 5.1.1.1 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
COIBCLKI_00084 2e-200 alr 5.1.1.1, 5.1.1.5 E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
COIBCLKI_00085 0.0 recG 3.6.4.12 L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
COIBCLKI_00087 2.6e-233 fabF 2.3.1.179 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
COIBCLKI_00088 5.6e-54 accB 2.3.1.12, 4.1.1.3 I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
COIBCLKI_00089 1.5e-71 fabZ 3.5.1.108, 4.2.1.59 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
COIBCLKI_00090 5.4e-256 accC 6.3.4.14, 6.4.1.2 I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
COIBCLKI_00091 2.3e-159 accD 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
COIBCLKI_00092 3.9e-139 accA 2.1.3.15, 6.4.1.2 I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
COIBCLKI_00093 4.7e-90 luxS 4.4.1.21 H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
COIBCLKI_00094 1.6e-206 rny D Endoribonuclease that initiates mRNA decay
COIBCLKI_00095 1.4e-112 fruR K transcriptional
COIBCLKI_00096 8.4e-165 pfkB 2.7.1.11, 2.7.1.56 H Belongs to the carbohydrate kinase PfkB family. LacC subfamily
COIBCLKI_00097 0.0 fruA 2.7.1.202 G phosphotransferase system
COIBCLKI_00098 7.1e-261 gor 1.8.1.7 C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
COIBCLKI_00099 3.4e-241 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
COIBCLKI_00101 2.6e-211 iscS2 2.8.1.7 E Cysteine sulfinate desulfinase cysteine desulfurase and related enzymes
COIBCLKI_00102 3.1e-223 thiI 2.8.1.4 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
COIBCLKI_00103 1.1e-291 gtf1 2.4.1.52 GT4 M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
COIBCLKI_00104 2e-255 gtf2 M A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1
COIBCLKI_00105 1.7e-93 2.3.1.128 K acetyltransferase
COIBCLKI_00106 2.8e-202 dinB 2.7.7.7 L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
COIBCLKI_00107 2.8e-35
COIBCLKI_00108 2e-152 yxeM ET ABC-type amino acid transport signal transduction systems, periplasmic component domain
COIBCLKI_00109 1.3e-157 yxeN P ABC transporter (Permease
COIBCLKI_00110 6.1e-129 tcyN 3.6.3.21 E abc transporter atp-binding protein
COIBCLKI_00111 5e-10 S Protein of unknown function (DUF4059)
COIBCLKI_00112 1.8e-170 trxB 1.8.1.9 C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
COIBCLKI_00113 5.6e-92 rsmD 2.1.1.171 L Methyltransferase
COIBCLKI_00114 5e-87 coaD 2.7.7.3 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
COIBCLKI_00115 4.2e-187 ylbL T Belongs to the peptidase S16 family
COIBCLKI_00116 5.4e-183 yhcC S radical SAM protein
COIBCLKI_00117 1.7e-96 ytqB J (SAM)-dependent
COIBCLKI_00119 0.0 yjcE P NhaP-type Na H and K H antiporters
COIBCLKI_00120 2.1e-143 modF 3.6.3.21, 3.6.3.34 P abc transporter atp-binding protein
COIBCLKI_00121 3.8e-238 hlyX S COG1253 Hemolysins and related proteins containing CBS domains
COIBCLKI_00122 1.5e-07 MU outer membrane autotransporter barrel domain protein
COIBCLKI_00123 5.6e-219 metE 2.1.1.14 E Methionine synthase
COIBCLKI_00124 1e-210 2.7.1.201, 2.7.1.208, 2.7.1.211 G pts system
COIBCLKI_00125 2.7e-241 hisS 6.1.1.21 J histidyl-tRNA synthetase
COIBCLKI_00127 0.0 aspS 6.1.1.12 J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
COIBCLKI_00128 3.2e-167 XK27_01785 S cog cog1284
COIBCLKI_00129 3e-122 yaaA S Belongs to the UPF0246 family
COIBCLKI_00130 2.4e-115 nrdG 1.97.1.4 O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
COIBCLKI_00131 4.1e-89 XK27_10930 K acetyltransferase
COIBCLKI_00132 7.5e-14
COIBCLKI_00133 0.0 nrdD 1.1.98.6 F Ribonucleoside-triphosphate reductase
COIBCLKI_00134 4e-290 ccs S the current gene model (or a revised gene model) may contain a frame shift
COIBCLKI_00135 3.2e-44 yrzB S Belongs to the UPF0473 family
COIBCLKI_00136 1.8e-69 yqgF L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
COIBCLKI_00137 6.3e-44 yrzL S Belongs to the UPF0297 family
COIBCLKI_00138 8.4e-27 rpmB J Belongs to the bacterial ribosomal protein bL28 family
COIBCLKI_00139 3.7e-235 rarA L ATPase related to the helicase subunit of the Holliday junction resolvase
COIBCLKI_00141 4.8e-63 int L Belongs to the 'phage' integrase family
COIBCLKI_00142 9.2e-300 O MreB/Mbl protein
COIBCLKI_00144 5.8e-146 V Psort location CytoplasmicMembrane, score
COIBCLKI_00147 1.5e-13
COIBCLKI_00148 1.5e-234 dcuS 2.7.13.3 T protein histidine kinase activity
COIBCLKI_00149 1.1e-243 2.7.13.3 T protein histidine kinase activity
COIBCLKI_00150 0.0 rexB 3.1.21.3, 3.6.4.12 L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
COIBCLKI_00151 0.0 addA 3.6.4.12 L ATP-dependent helicase nuclease subunit A
COIBCLKI_00152 1.4e-178 pyrD 1.3.1.14, 1.3.98.1 F Catalyzes the conversion of dihydroorotate to orotate
COIBCLKI_00154 6.3e-39 hup L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
COIBCLKI_00155 3.4e-95 ypmS S Protein conserved in bacteria
COIBCLKI_00156 3.9e-159 ypmR E COG2755 Lysophospholipase L1 and related esterases
COIBCLKI_00157 9.8e-144 DegV S DegV family
COIBCLKI_00158 1.1e-300 recN L May be involved in recombinational repair of damaged DNA
COIBCLKI_00159 8.3e-73 argR K Regulates arginine biosynthesis genes
COIBCLKI_00160 3.2e-147 rrmJ 2.1.1.226, 2.1.1.227 J Ribosomal RNA large subunit methyltransferase J
COIBCLKI_00161 8.4e-154 ispA 2.5.1.1, 2.5.1.10, 2.5.1.29, 2.5.1.90 H Belongs to the FPP GGPP synthase family
COIBCLKI_00162 1.3e-28 xseB 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
COIBCLKI_00163 4.7e-233 xseA 3.1.11.6 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
COIBCLKI_00164 6e-07 KT response to antibiotic
COIBCLKI_00165 1.3e-119 nth 4.2.99.18 L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
COIBCLKI_00166 1.3e-125 dnaD
COIBCLKI_00167 2.7e-182 metA 2.3.1.46 E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
COIBCLKI_00168 9.9e-94 apt 2.4.2.22, 2.4.2.7 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
COIBCLKI_00169 0.0 recJ L Single-strand DNA-specific exonuclease, C terminal domain
COIBCLKI_00170 3.1e-146 XK27_08080 3.1.1.53 G Exopolysaccharide biosynthesis protein
COIBCLKI_00171 1.8e-60 XK27_08085
COIBCLKI_00172 4.2e-192 hisC 2.6.1.9 E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
COIBCLKI_00173 5.5e-178 hisZ 2.4.2.17, 6.1.1.21 E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
COIBCLKI_00174 5.5e-118 hisG 2.4.2.17 E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
COIBCLKI_00175 3.2e-234 hisD 1.1.1.23, 1.1.1.308 E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
COIBCLKI_00176 6.7e-107 hisB 1.1.1.23, 2.6.1.9, 3.1.3.15, 4.2.1.19 E imidazoleglycerol-phosphate dehydratase
COIBCLKI_00177 2.3e-110 hisH E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
COIBCLKI_00178 4.8e-131 hisA 5.3.1.16 E 1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
COIBCLKI_00179 8.1e-137 hisF 3.5.4.19, 3.6.1.31 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
COIBCLKI_00180 4.7e-60 hisI 3.5.4.19, 3.5.4.25, 3.6.1.31, 5.3.1.16 E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
COIBCLKI_00181 4.1e-50 hisE 3.5.4.19, 3.6.1.31, 5.3.1.16 E phosphoribosyl-ATP diphosphatase activity
COIBCLKI_00183 2e-94 XK27_05505 S Psort location CytoplasmicMembrane, score
COIBCLKI_00184 2e-143 P molecular chaperone
COIBCLKI_00185 7.2e-98 S Carbohydrate-binding domain-containing protein Cthe_2159
COIBCLKI_00186 1.3e-177 XK27_08075 M glycosyl transferase family 2
COIBCLKI_00188 1.4e-164 metQ M Belongs to the NlpA lipoprotein family
COIBCLKI_00189 4.5e-263 dapE 3.5.1.18 E COG0624, acetylornithine deacetylase succinyl-diaminopimelate desuccinylase and related deacylases
COIBCLKI_00190 2.7e-186 metN P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
COIBCLKI_00191 1.2e-99 metI P ABC transporter (Permease
COIBCLKI_00192 4.6e-211 sstT E Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
COIBCLKI_00193 4.6e-157 salL 2.5.1.63, 2.5.1.94 S S-adenosyl-l-methionine hydroxide adenosyltransferase
COIBCLKI_00194 1.4e-93 S UPF0397 protein
COIBCLKI_00195 0.0 ykoD P abc transporter atp-binding protein
COIBCLKI_00196 7.7e-149 cbiQ P cobalt transport
COIBCLKI_00197 4.2e-121 ktrA P COG0569 K transport systems, NAD-binding component
COIBCLKI_00198 2.9e-238 P COG0168 Trk-type K transport systems, membrane components
COIBCLKI_00199 1e-128 rsmG 2.1.1.170 J Ribosomal RNA small subunit methyltransferase G
COIBCLKI_00200 3.1e-90 yceD K metal-binding, possibly nucleic acid-binding protein
COIBCLKI_00201 7.9e-123 T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
COIBCLKI_00202 1.6e-94 hpf J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
COIBCLKI_00203 1.7e-82 comFC S Competence protein
COIBCLKI_00204 1.8e-248 comFA L Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
COIBCLKI_00205 1.1e-107 yvyE 3.4.13.9 S YigZ family
COIBCLKI_00206 6.3e-168 cysK 2.5.1.47 E Belongs to the cysteine synthase cystathionine beta- synthase family
COIBCLKI_00207 3.3e-110 acuB S CBS domain
COIBCLKI_00208 1.6e-123 livF E COG0410 ABC-type branched-chain amino acid transport systems, ATPase component
COIBCLKI_00209 3.1e-136 livG E COG0411 ABC-type branched-chain amino acid transport systems, ATPase component
COIBCLKI_00210 4.9e-139 livM E Belongs to the binding-protein-dependent transport system permease family
COIBCLKI_00211 4.2e-145 livH E Belongs to the binding-protein-dependent transport system permease family
COIBCLKI_00212 2.8e-213 livJ E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component
COIBCLKI_00213 1.9e-46 ylbG S UPF0298 protein
COIBCLKI_00214 3e-72 ylbF S Belongs to the UPF0342 family
COIBCLKI_00215 3.7e-105 clpP 3.4.21.92 OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
COIBCLKI_00216 5.7e-112 upp 2.4.2.9 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
COIBCLKI_00217 0.0 sacB 2.4.1.10, 2.4.1.9, 3.2.1.26 GH32,GH68 G Belongs to the glycosyl hydrolase 68 family
COIBCLKI_00218 3.7e-132 ecfT P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
COIBCLKI_00219 5.2e-153 ecfA2 3.6.3.55 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
COIBCLKI_00220 4.1e-150 ecfA1 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
COIBCLKI_00221 4.1e-90 pgsA 2.7.8.41, 2.7.8.5 I Belongs to the CDP-alcohol phosphatidyltransferase class-I family
COIBCLKI_00222 1.7e-130 S sequence-specific DNA binding
COIBCLKI_00223 5.2e-237 ymfH S Peptidase M16
COIBCLKI_00224 1.9e-231 ymfF S Peptidase M16
COIBCLKI_00225 3.7e-58 yaaA S S4 domain protein YaaA
COIBCLKI_00226 2e-200 recF L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
COIBCLKI_00227 5.6e-275 guaB 1.1.1.205 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
COIBCLKI_00228 2.2e-193 trpS 6.1.1.2 J Tryptophanyl-tRNA synthetase
COIBCLKI_00229 7.1e-153 yvjA S membrane
COIBCLKI_00230 5.1e-306 ybiT S abc transporter atp-binding protein
COIBCLKI_00231 4.9e-51 K transcriptional regulator
COIBCLKI_00232 6.2e-243 lysA 4.1.1.20 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
COIBCLKI_00233 7.1e-12 ycdA S Domain of unknown function (DUF4352)
COIBCLKI_00234 2.2e-101 ybhL S Belongs to the BI1 family
COIBCLKI_00235 7.3e-94 XK27_09705 6.1.1.14 S HD superfamily hydrolase
COIBCLKI_00236 3.9e-128 spoU 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
COIBCLKI_00237 6e-45 acyP 3.6.1.7 C Belongs to the acylphosphatase family
COIBCLKI_00238 2.2e-165 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
COIBCLKI_00239 1.2e-77 greA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
COIBCLKI_00240 2.1e-301 mltG ADL Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
COIBCLKI_00241 1.3e-87 XK27_09675 K histone acetyltransferase HPA2 and related acetyltransferases
COIBCLKI_00242 4.7e-257 mpl 6.3.2.4, 6.3.2.45, 6.3.2.8 M Belongs to the MurCDEF family
COIBCLKI_00243 9.6e-23
COIBCLKI_00244 0.0 snf 2.7.11.1 L Superfamily II DNA RNA helicases, SNF2 family'
COIBCLKI_00245 3.9e-173 rsmH 2.1.1.199 J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
COIBCLKI_00246 2.4e-45 ftsL D cell division protein FtsL
COIBCLKI_00247 0.0 ftsI 3.4.16.4 M penicillin-binding protein
COIBCLKI_00248 4.5e-183 mraY 2.7.8.13 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
COIBCLKI_00249 1.2e-220 cshB 3.6.4.13 JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
COIBCLKI_00252 9.6e-269 yunD 3.1.3.5 F Belongs to the 5'-nucleotidase family
COIBCLKI_00253 1.7e-62 yutD J protein conserved in bacteria
COIBCLKI_00254 1.8e-223 rlmN 2.1.1.192 J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
COIBCLKI_00255 1e-90 XK27_09885 V Glycopeptide antibiotics resistance protein
COIBCLKI_00257 0.0 mdlA V abc transporter atp-binding protein
COIBCLKI_00258 0.0 mdlB V abc transporter atp-binding protein
COIBCLKI_00259 9.8e-51 mscL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
COIBCLKI_00260 0.0 dnaG L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
COIBCLKI_00261 2.3e-201 sigA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
COIBCLKI_00262 3.4e-55 yitW K metal-sulfur cluster biosynthetic enzyme
COIBCLKI_00263 2.5e-172 yfdH GT2 M COG0463, glycosyltransferases involved in cell wall biogenesis
COIBCLKI_00264 7.6e-160 rfbD 1.1.1.133, 5.1.3.13 M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
COIBCLKI_00265 1.2e-213 rgpA GT4 M Domain of unknown function (DUF1972)
COIBCLKI_00266 2.6e-172 rgpB GT2 M Glycosyltransferase, group 2 family protein
COIBCLKI_00267 5.2e-142 rgpC GM Transport permease protein
COIBCLKI_00268 5.3e-223 rgpD 3.6.3.38 P Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system
COIBCLKI_00269 3.5e-183 rgpEc GT2 M Glycosyl transferase family 2
COIBCLKI_00270 0.0 rgpF M Rhamnan synthesis protein F
COIBCLKI_00271 4.3e-156 rfbJ M Glycosyl transferase family 2
COIBCLKI_00272 7.8e-143 trpA 4.2.1.20 E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
COIBCLKI_00273 3.4e-230 trpB 4.2.1.20, 5.3.1.24 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
COIBCLKI_00274 1.1e-98 trpF 4.1.1.48, 4.2.1.160, 4.2.1.20, 5.3.1.24 E belongs to the TrpF family
COIBCLKI_00275 3.2e-133 trpC 4.1.1.48, 5.3.1.24 E Belongs to the TrpC family
COIBCLKI_00276 2.5e-178 trpD 2.4.2.18, 4.1.3.27 F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
COIBCLKI_00277 2.7e-105 trpG 2.4.2.18, 2.6.1.85, 4.1.3.27 EH anthranilate
COIBCLKI_00278 1.1e-256 trpE 4.1.3.27 EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
COIBCLKI_00279 3.4e-40 pchB 2.5.1.19, 4.2.1.10, 4.2.99.21, 5.4.99.5 E Chorismate mutase type II
COIBCLKI_00280 1.2e-59
COIBCLKI_00281 0.0 ctpE P E1-E2 ATPase
COIBCLKI_00282 6.8e-47
COIBCLKI_00283 1.2e-43 yaaK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
COIBCLKI_00285 8.9e-14 MA20_06245 S yiaA/B two helix domain
COIBCLKI_00286 2e-132 pip 1.11.1.10 S Alpha beta hydrolase
COIBCLKI_00287 0.0 mprF 2.3.2.3 J Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
COIBCLKI_00288 2.3e-150 cobQ S glutamine amidotransferase
COIBCLKI_00289 9.9e-255 murD 3.4.21.10, 6.3.2.13, 6.3.2.9 M Mur ligase, middle domain protein
COIBCLKI_00290 6.7e-148 dacA 2.7.7.85 S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
COIBCLKI_00291 7.8e-169 ybbR S Protein conserved in bacteria
COIBCLKI_00292 1.3e-249 glmM 5.4.2.10 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
COIBCLKI_00293 5e-64 gtrA S GtrA-like protein
COIBCLKI_00294 2.6e-118 trmK 2.1.1.217 S SAM-dependent methyltransferase
COIBCLKI_00295 6.4e-145 yqfO 3.5.4.16 S Belongs to the GTP cyclohydrolase I type 2 NIF3 family
COIBCLKI_00296 8e-146 zupT P Mediates zinc uptake. May also transport other divalent cations
COIBCLKI_00297 2.4e-168 manL 2.7.1.191 G pts system
COIBCLKI_00298 4.8e-132 manY G pts system
COIBCLKI_00299 1.4e-159 manN G PTS system mannose fructose sorbose family IID component
COIBCLKI_00300 1e-66 manO S Protein conserved in bacteria
COIBCLKI_00301 4.9e-174 manL 2.7.1.191 G pts system
COIBCLKI_00302 1.7e-116 manM G pts system
COIBCLKI_00303 3.3e-169 manN G PTS system mannose fructose sorbose family IID component
COIBCLKI_00304 2.7e-61 manO S protein conserved in bacteria
COIBCLKI_00305 2e-228 serS 6.1.1.11 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
COIBCLKI_00306 1.1e-102
COIBCLKI_00307 2.6e-247 der 1.1.1.399, 1.1.1.95 S GTPase that plays an essential role in the late steps of ribosome biogenesis
COIBCLKI_00308 1.5e-166 dnaI L Primosomal protein DnaI
COIBCLKI_00309 4.7e-216 dnaB L Replication initiation and membrane attachment
COIBCLKI_00310 1.4e-81 nrdR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
COIBCLKI_00311 1.4e-173 tsaD 2.3.1.234 O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
COIBCLKI_00312 3.9e-114 azlC E AzlC protein
COIBCLKI_00313 1.1e-45 azlD S branched-chain amino acid
COIBCLKI_00314 0.0 recD2 3.1.11.5 L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
COIBCLKI_00315 1.5e-115 lepB 3.4.21.89 U Belongs to the peptidase S26 family
COIBCLKI_00316 3.8e-154 rnhC 3.1.26.4 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
COIBCLKI_00317 2.7e-14 zapA D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
COIBCLKI_00318 1.3e-93 cvpA S toxin biosynthetic process
COIBCLKI_00319 0.0 mutS2 L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
COIBCLKI_00320 0.0 polA 2.7.7.7 L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
COIBCLKI_00322 2e-172 fabK 1.3.1.9 S 2-Nitropropane dioxygenase
COIBCLKI_00323 3.3e-30 acpP IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
COIBCLKI_00324 1.1e-170 fabH 2.3.1.180 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
COIBCLKI_00325 5.2e-72 marR K Transcriptional regulator, MarR family
COIBCLKI_00326 2.1e-140 phaB 5.3.3.14, 5.3.3.18 I Belongs to the enoyl-CoA hydratase isomerase family
COIBCLKI_00327 1.3e-111 S HAD hydrolase, family IA, variant 3
COIBCLKI_00328 5.3e-256 lysC 2.7.2.4 E Belongs to the aspartokinase family
COIBCLKI_00329 3e-192 asnA 6.3.1.1 E aspartate--ammonia ligase
COIBCLKI_00330 4.2e-245 rumA 2.1.1.190, 2.1.1.35 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
COIBCLKI_00331 2e-138 recX 2.4.1.337 GT4 S Regulatory protein RecX
COIBCLKI_00332 7.8e-102 ygaC J Belongs to the UPF0374 family
COIBCLKI_00333 1.4e-107 S Domain of unknown function (DUF1803)
COIBCLKI_00334 3.5e-166 ppaC 3.6.1.1 C inorganic pyrophosphatase
COIBCLKI_00337 2e-180 msrA 1.8.4.11, 1.8.4.12 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
COIBCLKI_00338 8.1e-233 brnQ E Component of the transport system for branched-chain amino acids
COIBCLKI_00339 1.7e-181 manA 5.3.1.8 G mannose-6-phosphate isomerase
COIBCLKI_00340 1.8e-59 S Protein of unknown function (DUF3290)
COIBCLKI_00341 1.5e-107 S Protein of unknown function (DUF421)
COIBCLKI_00342 1.4e-16 csbD S CsbD-like
COIBCLKI_00343 7.5e-118 S Carbohydrate-binding domain-containing protein Cthe_2159
COIBCLKI_00344 3e-51 XK27_01300 S ASCH
COIBCLKI_00345 2.1e-215 yfnA E amino acid
COIBCLKI_00346 1.1e-43 asd 1.2.1.11 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
COIBCLKI_00347 1.7e-173 dapA 4.3.3.7 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
COIBCLKI_00348 2.5e-124 rnc 3.1.26.3 J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
COIBCLKI_00349 0.0 smc D Required for chromosome condensation and partitioning
COIBCLKI_00350 4.2e-87 S Protein of unknown function (DUF3278)
COIBCLKI_00351 1.1e-22 WQ51_00220 K Helix-turn-helix domain
COIBCLKI_00352 6.6e-198 pheS 6.1.1.20 J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
COIBCLKI_00353 4.1e-92 paiA 2.3.1.57 K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
COIBCLKI_00354 0.0 pheT 6.1.1.20 J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
COIBCLKI_00356 7.3e-189 leuB 1.1.1.85 CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
COIBCLKI_00357 1.2e-276 leuC 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
COIBCLKI_00358 1.1e-112 leuD 4.2.1.33, 4.2.1.35 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
COIBCLKI_00359 0.0 dnaE 2.7.7.7 L DNA polymerase
COIBCLKI_00360 2.1e-188 pfkA 2.7.1.11 F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
COIBCLKI_00361 3.5e-277 pyk 2.7.1.40, 2.7.7.4 G Belongs to the pyruvate kinase family
COIBCLKI_00362 4.8e-31 L COG1943 Transposase and inactivated derivatives
COIBCLKI_00363 3.8e-18 S Domain of unknown function (DUF4649)
COIBCLKI_00364 1.4e-176 XK27_08835 S ABC transporter substrate binding protein
COIBCLKI_00365 0.0 ftsH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
COIBCLKI_00366 2e-97 hpt 2.4.2.8, 6.3.4.19 F Belongs to the purine pyrimidine phosphoribosyltransferase family
COIBCLKI_00367 3.2e-231 tilS 2.4.2.8, 6.3.4.19 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
COIBCLKI_00368 1.3e-238 XK27_09285 3.5.2.6 V Beta-lactamase enzyme family
COIBCLKI_00370 3e-60 divIC D Septum formation initiator
COIBCLKI_00371 2.2e-39 yabO J Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
COIBCLKI_00372 0.0 mfd L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
COIBCLKI_00373 3e-104 pth 3.1.1.29 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
COIBCLKI_00374 1.1e-203 ychF J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
COIBCLKI_00375 1.1e-29 yyzM S Protein conserved in bacteria
COIBCLKI_00376 7.7e-49 dnaN 2.7.7.7 L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
COIBCLKI_00377 2.2e-179 pta 2.3.1.8, 3.6.3.21 C phosphate acetyltransferase
COIBCLKI_00378 1.2e-171 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 J Responsible for synthesis of pseudouridine from uracil
COIBCLKI_00379 7.5e-152 nadK 2.7.1.23 H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
COIBCLKI_00380 1.4e-119 yjbM 2.7.6.5 S Gtp pyrophosphokinase
COIBCLKI_00381 7.8e-100 yjbK S Adenylate cyclase
COIBCLKI_00382 5.1e-176 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
COIBCLKI_00383 2.7e-205 iscS 2.8.1.7 E Cysteine desulfurase
COIBCLKI_00384 8.2e-60 XK27_04120 S Putative amino acid metabolism
COIBCLKI_00385 2.1e-117 rex K Modulates transcription in response to changes in cellular NADH NAD( ) redox state
COIBCLKI_00386 9.1e-127 puuD T peptidase C26
COIBCLKI_00387 1.5e-113 radC E Belongs to the UPF0758 family
COIBCLKI_00388 2e-166
COIBCLKI_00389 8e-67 mrnC J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
COIBCLKI_00390 8.1e-257 cysS 6.1.1.16, 6.3.1.13 J Belongs to the class-I aminoacyl-tRNA synthetase family
COIBCLKI_00392 3.3e-112 cysE 2.3.1.30 E serine acetyltransferase
COIBCLKI_00393 5.1e-139 S SseB protein N-terminal domain
COIBCLKI_00394 0.0 pnp 2.7.7.8 J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
COIBCLKI_00395 7.3e-228 dacA 3.4.16.4 M Belongs to the peptidase S11 family
COIBCLKI_00396 1.2e-230 dacA 3.4.16.4 M Belongs to the peptidase S11 family
COIBCLKI_00397 0.0 clpC O Belongs to the ClpA ClpB family
COIBCLKI_00398 8.2e-67 ctsR K Belongs to the CtsR family
COIBCLKI_00399 1.9e-267 pncB 6.3.4.21 H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
COIBCLKI_00400 9e-150 nadE 6.3.1.5 H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
COIBCLKI_00401 5.3e-72 yhaI S Protein of unknown function (DUF805)
COIBCLKI_00402 1.3e-254 pepC 3.4.22.40 E aminopeptidase
COIBCLKI_00403 0.0 ponA 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
COIBCLKI_00404 8.1e-108 recU L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
COIBCLKI_00405 1.8e-95 ypsA S Belongs to the UPF0398 family
COIBCLKI_00406 5.6e-50 gpsB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
COIBCLKI_00407 1.3e-223 rlmL 2.1.1.173, 2.1.1.264 L Belongs to the methyltransferase superfamily
COIBCLKI_00409 0.0 ftsK D Belongs to the FtsK SpoIIIE SftA family
COIBCLKI_00410 4.6e-188 trxB1 1.18.1.2, 1.19.1.1 C Ferredoxin--NADP reductase
COIBCLKI_00411 1.9e-135 trmD 2.1.1.228, 4.6.1.12 J Belongs to the RNA methyltransferase TrmD family
COIBCLKI_00412 7.6e-94 rimM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
COIBCLKI_00415 1.4e-113 vraR K Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
COIBCLKI_00416 1.9e-170 vraS 2.7.13.3 T Histidine kinase
COIBCLKI_00417 3.3e-116 yvqF S Membrane
COIBCLKI_00418 3.1e-104 kcsA P Ion transport protein
COIBCLKI_00419 1.4e-153 prkC 2.7.11.1 KLT serine threonine protein kinase
COIBCLKI_00420 6e-132 folC 6.3.2.12, 6.3.2.17 H Belongs to the folylpolyglutamate synthase family
COIBCLKI_00421 0.0 ydaO E amino acid
COIBCLKI_00422 7.7e-100 folE 3.5.4.16 F gtp cyclohydrolase
COIBCLKI_00423 5.3e-142 folP 2.5.1.15, 2.7.6.3 H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
COIBCLKI_00424 6.4e-292 amy 3.2.1.1 GH13 G Belongs to the glycosyl hydrolase 13 family
COIBCLKI_00425 1e-60 folB 1.13.11.81, 2.5.1.15, 2.7.6.3, 4.1.2.25, 5.1.99.8 H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
COIBCLKI_00426 1.4e-81 folK 2.7.6.3, 4.1.2.25 H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
COIBCLKI_00427 9.5e-169 murB 1.3.1.98 M cell wall formation
COIBCLKI_00428 5.2e-212 potA 3.6.3.30, 3.6.3.31 P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
COIBCLKI_00429 4.1e-139 potB P ABC-type spermidine putrescine transport system, permease component I
COIBCLKI_00430 2.3e-131 potC P ABC-type spermidine putrescine transport system, permease component II
COIBCLKI_00431 6.1e-205 recA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
COIBCLKI_00432 5e-232 cinA 3.5.1.42 S Belongs to the CinA family
COIBCLKI_00433 2.2e-107 tag 3.2.2.20 L 3-methyladenine DNA glycosylase
COIBCLKI_00434 3e-102 ruvA 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
COIBCLKI_00436 0.0 mutL L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
COIBCLKI_00438 5.3e-72 K LytTr DNA-binding domain
COIBCLKI_00439 1.2e-79 S Protein of unknown function (DUF3021)
COIBCLKI_00440 0.0 mutS L that it carries out the mismatch recognition step. This protein has a weak ATPase activity
COIBCLKI_00441 3.3e-56 ymcA 3.6.3.21 S Belongs to the UPF0342 family
COIBCLKI_00442 3.1e-69 argR K Regulates arginine biosynthesis genes
COIBCLKI_00443 6.1e-157 galK 2.7.1.6 G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
COIBCLKI_00444 5e-287 galT 2.7.7.12 G UDPglucose--hexose-1-phosphate uridylyltransferase
COIBCLKI_00445 8.6e-195 galE 5.1.3.2 M Belongs to the NAD(P)-dependent epimerase dehydratase family
COIBCLKI_00446 1.1e-200 galM 5.1.3.3 G Catalyzes the interconversion of alpha and beta anomers of maltose
COIBCLKI_00447 0.0 lacS G transporter
COIBCLKI_00448 0.0 lacL 3.2.1.23 G -beta-galactosidase
COIBCLKI_00449 1.3e-210 S Tetratricopeptide repeat
COIBCLKI_00450 3e-87 licT K antiterminator
COIBCLKI_00451 4.6e-88 ybeY 2.6.99.2, 3.5.4.5 S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
COIBCLKI_00452 2e-65 dgkA 2.7.1.107, 2.7.1.66 M Diacylglycerol kinase
COIBCLKI_00453 3.4e-166 era M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
COIBCLKI_00454 6.9e-150 fpg 3.2.2.23, 4.2.99.18 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
COIBCLKI_00455 8.6e-102 coaE 2.7.1.24, 3.2.2.23, 4.2.99.18 GH23 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
COIBCLKI_00456 9.1e-223 mdtG EGP Major facilitator Superfamily
COIBCLKI_00457 2e-33 secG U Preprotein translocase subunit SecG
COIBCLKI_00458 0.0 rnr J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
COIBCLKI_00459 2.5e-80 smpB O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
COIBCLKI_00460 2.1e-276 ppiB 5.2.1.8 G PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
COIBCLKI_00461 1.3e-63 yugI 5.3.1.9 J RNA binding protein, contains ribosomal protein S1 domain
COIBCLKI_00462 1.7e-104 pepQ 3.4.13.9 E Belongs to the peptidase M24B family
COIBCLKI_00463 0.0 alaS 6.1.1.7 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
COIBCLKI_00464 7.8e-168 prsA 3.1.3.16, 5.2.1.8 O peptidyl-prolyl cis-trans isomerase activity
COIBCLKI_00465 3.6e-120 yrrM 2.1.1.104 S O-Methyltransferase
COIBCLKI_00466 6.7e-218 oxlT P COG0477 Permeases of the major facilitator superfamily
COIBCLKI_00467 0.0 pepF E oligoendopeptidase F
COIBCLKI_00468 1.3e-184 coiA 3.6.4.12 S Competence protein
COIBCLKI_00469 5.2e-78 L transposition
COIBCLKI_00470 1.7e-07
COIBCLKI_00471 5.6e-135 agrA KT response regulator
COIBCLKI_00472 3.4e-231 2.7.13.3 T GHKL domain
COIBCLKI_00474 0.0 vanY 3.4.17.14, 3.5.1.28 M D-alanyl-D-alanine carboxypeptidase
COIBCLKI_00475 1.5e-141 cnhA 3.5.1.3 S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
COIBCLKI_00476 4.5e-227 mtnE 2.6.1.83 E mutations do not affect methionine salvage in vivo however
COIBCLKI_00477 5.7e-186 argC 1.2.1.38 E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
COIBCLKI_00478 6.7e-63 paaI Q protein possibly involved in aromatic compounds catabolism
COIBCLKI_00479 2.2e-09 O ADP-ribosylglycohydrolase
COIBCLKI_00480 1.3e-131 rsuA 5.4.99.19, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
COIBCLKI_00482 6.7e-248 obg S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
COIBCLKI_00483 1.7e-17 XK27_00735
COIBCLKI_00484 5.7e-135 glnQ 3.6.3.21 E abc transporter atp-binding protein
COIBCLKI_00485 0.0 glnP P ABC-type amino acid transport signal transduction systems periplasmic component domain
COIBCLKI_00486 1.1e-167 S CAAX amino terminal protease family protein
COIBCLKI_00488 0.0 uvrB L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
COIBCLKI_00489 1.6e-247 pbuO S permease
COIBCLKI_00490 9.4e-77 ydiB 2.7.1.221, 5.1.1.1 M ATPase or kinase
COIBCLKI_00491 6e-91 XK27_05885 2.3.1.82 M phosphinothricin N-acetyltransferase activity
COIBCLKI_00492 2e-212 brpA K Transcriptional
COIBCLKI_00493 2.3e-81 rimP S Required for maturation of 30S ribosomal subunits
COIBCLKI_00494 2.4e-196 nusA K Participates in both transcription termination and antitermination
COIBCLKI_00495 2.7e-48 ylxR K Nucleic-acid-binding protein implicated in transcription termination
COIBCLKI_00496 1.5e-46 ylxQ J ribosomal protein
COIBCLKI_00497 0.0 infB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
COIBCLKI_00498 8.6e-57 rbfA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
COIBCLKI_00499 5.3e-101 yvdD 3.2.2.10 S Belongs to the LOG family
COIBCLKI_00501 1.7e-187 fni 1.1.1.88, 5.3.3.2 C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
COIBCLKI_00502 7.8e-172 mvaK2 2.7.1.36, 2.7.1.43, 2.7.4.2 I phosphomevalonate kinase
COIBCLKI_00503 1.7e-168 mvaD 4.1.1.33 I diphosphomevalonate decarboxylase
COIBCLKI_00504 3.9e-135 mvk 1.1.1.88, 2.3.3.10, 2.7.1.36 I mevalonate kinase
COIBCLKI_00505 1.5e-247 merA 1.16.1.1 C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
COIBCLKI_00506 4.8e-140 E Alpha beta hydrolase
COIBCLKI_00508 8.3e-199 ald 1.4.1.1 C Belongs to the AlaDH PNT family
COIBCLKI_00509 1.1e-217 hipO 3.5.1.47 E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
COIBCLKI_00510 2.4e-72 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
COIBCLKI_00511 7.1e-224 ftsA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
COIBCLKI_00512 2.2e-133 divIB D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
COIBCLKI_00513 8.6e-201 murG 2.4.1.227 GT28 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
COIBCLKI_00514 1.8e-251 murD 6.3.2.9 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
COIBCLKI_00516 0.0 typA T GTP-binding protein TypA
COIBCLKI_00517 3.5e-177 glk 2.7.1.2 G Glucokinase
COIBCLKI_00518 2.4e-27 yqgQ S protein conserved in bacteria
COIBCLKI_00519 5.2e-83 perR P Belongs to the Fur family
COIBCLKI_00520 9.3e-92 dps P Belongs to the Dps family
COIBCLKI_00521 1.2e-163 gla U Belongs to the MIP aquaporin (TC 1.A.8) family
COIBCLKI_00522 2.7e-99 V CAAX protease self-immunity
COIBCLKI_00523 3.2e-141 cppA E CppA N-terminal
COIBCLKI_00524 1.5e-172 ampC V COG1680 Beta-lactamase class C and other penicillin binding proteins
COIBCLKI_00525 4.8e-76 yjcF S COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
COIBCLKI_00526 4.4e-146 cah 4.2.1.1 P carbonic anhydrase
COIBCLKI_00527 0.0 lai 4.2.1.53 S Myosin-crossreactive antigen
COIBCLKI_00529 2.2e-226 pflB 2.3.1.54 C formate acetyltransferase'
COIBCLKI_00530 8.6e-249 msrR K Transcriptional regulator
COIBCLKI_00531 1.4e-153 pheA 4.2.1.51 E Prephenate dehydratase
COIBCLKI_00532 6.7e-76 aroK 1.1.1.25, 2.7.1.71, 4.2.1.10, 4.2.3.4 F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
COIBCLKI_00533 3.7e-235 aroA 1.3.1.12, 1.3.1.43, 2.5.1.19 E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
COIBCLKI_00534 2.4e-170 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily
COIBCLKI_00535 4.2e-53 yheA S Belongs to the UPF0342 family
COIBCLKI_00536 8.3e-207 tyrA 1.3.1.12, 1.3.1.43 E prephenate dehydrogenase
COIBCLKI_00537 9.9e-219 aroC 4.2.3.5 E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
COIBCLKI_00538 5.9e-202 aroB 2.7.1.71, 4.2.3.4 E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
COIBCLKI_00539 1.3e-159 aroE 1.1.1.25 E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
COIBCLKI_00540 3.2e-59 aroD 1.1.1.25, 4.2.1.10 E Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
COIBCLKI_00541 1.2e-301 3.2.1.26, 3.2.1.65 GH32 G Belongs to the glycosyl hydrolase 32 family
COIBCLKI_00542 1.3e-223 malY 4.4.1.8 E COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
COIBCLKI_00543 2.6e-200 metB 2.5.1.48, 4.4.1.8 E cystathionine
COIBCLKI_00544 0.0 pacL 3.6.3.8, 3.6.3.9 P cation transport ATPase
COIBCLKI_00545 2.9e-282 ytgP S Membrane protein involved in the export of O-antigen and teichoic acid
COIBCLKI_00546 1e-99 thiT S Thiamine transporter
COIBCLKI_00547 3.3e-62 yjqA S Bacterial PH domain
COIBCLKI_00548 2.8e-152 corA P CorA-like protein
COIBCLKI_00549 2.2e-245 cshA 3.6.4.13 JKL DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
COIBCLKI_00550 7e-43 yazA L endonuclease containing a URI domain
COIBCLKI_00551 5.5e-141 yabB 2.1.1.223 L Methyltransferase
COIBCLKI_00552 1.1e-154 nodB3 G deacetylase
COIBCLKI_00553 9.8e-143 plsC 2.3.1.51 I Acyltransferase
COIBCLKI_00554 3.5e-94 comEA L COG1555 DNA uptake protein and related DNA-binding proteins
COIBCLKI_00555 0.0 comEC S Competence protein ComEC
COIBCLKI_00556 3.2e-220 treB 2.7.1.201, 2.7.1.208, 2.7.1.211 G pts system
COIBCLKI_00557 6.6e-61 treB 2.7.1.201 G pts system
COIBCLKI_00558 1.8e-117 treR K trehalose operon
COIBCLKI_00559 9.7e-95 ywlG S Belongs to the UPF0340 family
COIBCLKI_00562 8.2e-165 fba 4.1.2.13, 4.1.2.29 G aldolase
COIBCLKI_00564 2.7e-241 6.3.2.2 H gamma-glutamylcysteine synthetase
COIBCLKI_00565 4.4e-62 rplQ J ribosomal protein l17
COIBCLKI_00566 1.1e-170 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
COIBCLKI_00567 2.3e-27 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
COIBCLKI_00568 5.5e-144 cdsA 2.7.7.41 S Belongs to the CDS family
COIBCLKI_00569 6.1e-230 rseP 3.4.21.107, 3.4.21.116 M zinc metalloprotease
COIBCLKI_00570 0.0 proS 6.1.1.15 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
COIBCLKI_00571 0.0 WQ51_06230 S ABC transporter
COIBCLKI_00572 1.4e-142 cmpC S abc transporter atp-binding protein
COIBCLKI_00573 4.9e-42 groS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
COIBCLKI_00574 4.1e-287 groL O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
COIBCLKI_00576 4.8e-137 stp 3.1.3.16 T phosphatase
COIBCLKI_00577 4.6e-244 sun 2.1.1.176 J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
COIBCLKI_00578 8.1e-171 fmt 2.1.2.9 J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
COIBCLKI_00579 0.0 priA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
COIBCLKI_00580 7.9e-46 rpoZ 2.7.7.6 K DNA-directed 5'-3' RNA polymerase activity
COIBCLKI_00581 8.8e-113 gmk 2.7.4.8 F Essential for recycling GMP and indirectly, cGMP
COIBCLKI_00582 3.9e-193 ftsY U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
COIBCLKI_00583 6e-146 XK27_02985 S overlaps another CDS with the same product name
COIBCLKI_00584 1.4e-147 supH S overlaps another CDS with the same product name
COIBCLKI_00585 6.3e-51 trxA O Belongs to the thioredoxin family
COIBCLKI_00586 7.2e-74 yccU S CoA-binding protein
COIBCLKI_00587 6.6e-145 tatD L Hydrolase, tatd
COIBCLKI_00588 2.9e-99 rnmV 3.1.26.8 J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
COIBCLKI_00589 4.4e-155 ksgA 2.1.1.182 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
COIBCLKI_00591 4e-164 rsgA 3.1.3.100 G One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
COIBCLKI_00592 7.8e-120 rpe 5.1.3.1 G Belongs to the ribulose-phosphate 3-epimerase family
COIBCLKI_00593 1.1e-118 thiN 2.7.6.2 H thiamine pyrophosphokinase
COIBCLKI_00594 1.6e-169 rmuC S RmuC domain protein
COIBCLKI_00595 3.1e-178 cbf S 3'-5' exoribonuclease yhaM
COIBCLKI_00596 4e-142 purR 2.4.2.7 F operon repressor
COIBCLKI_00597 5.3e-141 uppS 2.5.1.31 H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
COIBCLKI_00598 3.1e-48 yajC U protein transport
COIBCLKI_00599 6.1e-126 yeeN K transcriptional regulatory protein
COIBCLKI_00600 6.5e-282 V ABC transporter
COIBCLKI_00601 1.5e-150 Z012_04635 K sequence-specific DNA binding
COIBCLKI_00602 1.6e-257 pgi 5.3.1.9 G Belongs to the GPI family
COIBCLKI_00603 1.7e-156 rgfB 3.1.3.90 L Endonuclease/Exonuclease/phosphatase family
COIBCLKI_00604 0.0 ptsG 2.7.1.199, 2.7.1.201, 2.7.1.208, 2.7.1.211 G pts system
COIBCLKI_00605 4.3e-228 malX G ABC transporter
COIBCLKI_00606 7.4e-250 malF P ABC transporter (Permease
COIBCLKI_00607 9.8e-152 malG P ABC transporter (Permease
COIBCLKI_00608 1.4e-212 msmX P Belongs to the ABC transporter superfamily
COIBCLKI_00609 3e-24 tatA U protein secretion
COIBCLKI_00610 1.1e-119 tatC U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
COIBCLKI_00611 1.6e-286 ywbL P COG0672 High-affinity Fe2 Pb2 permease
COIBCLKI_00612 5.5e-225 ycdB P peroxidase
COIBCLKI_00613 1.9e-23 K MerR, DNA binding
COIBCLKI_00614 0.0 L helicase
COIBCLKI_00615 3.2e-65 nudG 3.6.1.55, 3.6.1.65 L Belongs to the Nudix hydrolase family
COIBCLKI_00616 1.2e-09
COIBCLKI_00617 2.5e-234 mntH P H( )-stimulated, divalent metal cation uptake system
COIBCLKI_00618 1.1e-33 XK27_12190 S protein conserved in bacteria
COIBCLKI_00620 3.9e-85 bioY S biotin synthase
COIBCLKI_00621 1.7e-251 yegQ O Peptidase U32
COIBCLKI_00622 6.8e-178 yegQ O Peptidase U32
COIBCLKI_00623 3.8e-304 yloV S kinase related to dihydroxyacetone kinase
COIBCLKI_00624 1.4e-57 asp S cog cog1302
COIBCLKI_00625 2.1e-225 norN V Mate efflux family protein
COIBCLKI_00626 9.2e-278 thrC 4.2.3.1 E Threonine synthase
COIBCLKI_00629 1.2e-238 adhE 1.1.1.1, 1.2.1.10 C belongs to the iron- containing alcohol dehydrogenase family
COIBCLKI_00630 8.6e-168 yufQ S Belongs to the binding-protein-dependent transport system permease family
COIBCLKI_00631 1.3e-177 yufP S Belongs to the binding-protein-dependent transport system permease family
COIBCLKI_00632 1.6e-280 xylG 3.6.3.17 S ABC transporter, ATP-binding protein
COIBCLKI_00633 1.1e-192 tcsA S membrane
COIBCLKI_00634 1e-66 cdd 2.4.2.2, 3.5.4.5 F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
COIBCLKI_00635 1e-111 deoC 4.1.2.4, 5.4.2.8 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
COIBCLKI_00636 8.6e-232 pdp 2.4.2.2, 2.4.2.4 F Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate
COIBCLKI_00637 4.6e-103 rsmC 2.1.1.172 J Methyltransferase small domain protein
COIBCLKI_00638 3.6e-171 coaA 2.7.1.33 F Pantothenic acid kinase
COIBCLKI_00639 1e-29 rpsT J Binds directly to 16S ribosomal RNA
COIBCLKI_00640 1.5e-135 XK27_08845 S abc transporter atp-binding protein
COIBCLKI_00641 2.8e-310 rnjB S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
COIBCLKI_00642 9.5e-149 estA CE1 S Esterase
COIBCLKI_00643 1.6e-126 XK27_08875 O Zinc-dependent metalloprotease
COIBCLKI_00644 4.8e-18 XK27_08880
COIBCLKI_00645 1e-75 fld C Flavodoxin
COIBCLKI_00646 3.9e-279 clcA P Chloride transporter, ClC family
COIBCLKI_00647 2.6e-29 pheA 1.3.1.12, 2.3.1.79, 4.2.1.51, 5.4.99.5 E Chorismate mutase
COIBCLKI_00648 3.5e-214 XK27_05110 P Chloride transporter ClC family
COIBCLKI_00649 8.2e-64 grpE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
COIBCLKI_00650 3.7e-185 hrcA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
COIBCLKI_00651 3.2e-101 acmA 3.2.1.17, 3.4.17.14, 3.5.1.28 NU Muramidase (Flagellum-specific)
COIBCLKI_00652 8.2e-140 vanY 3.4.17.14 M D-alanyl-D-alanine carboxypeptidase
COIBCLKI_00653 7.3e-132 ais G Phosphoglycerate mutase
COIBCLKI_00654 2.3e-243 XK27_08635 S UPF0210 protein
COIBCLKI_00655 6.1e-39 gcvR T UPF0237 protein
COIBCLKI_00656 2.2e-232 capA M Bacterial capsule synthesis protein
COIBCLKI_00657 3.2e-139 srtB 3.4.22.70 S sortase, SrtB family
COIBCLKI_00658 6e-85
COIBCLKI_00659 1.6e-282 glgA 2.4.1.21 GT5 G Synthesizes alpha-1,4-glucan chains using ADP-glucose
COIBCLKI_00660 2.9e-178 glgD 2.4.1.21, 2.7.7.27 GT5 G glucose-1-phosphate adenylyltransferase
COIBCLKI_00661 4e-188 glgC 2.7.7.27 H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
COIBCLKI_00662 0.0 glgB 2.4.1.18, 3.2.1.141, 3.2.1.20 CBM48,GH13,GH31 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
COIBCLKI_00663 3.4e-103 pulA 3.2.1.41 CBM48,GH13 G belongs to the glycosyl hydrolase 13 family
COIBCLKI_00664 3.3e-264 gapN 1.2.1.9 C Belongs to the aldehyde dehydrogenase family
COIBCLKI_00665 6.1e-162 XK27_05670 S Putative esterase
COIBCLKI_00666 2.7e-153 XK27_05675 S Esterase
COIBCLKI_00667 9.9e-227 XK27_05680 6.3.2.2, 6.3.2.4 M carbamoylphosphate synthase large subunit
COIBCLKI_00668 3.2e-179 yfmL 3.6.4.13 L DEAD DEAH box helicase
COIBCLKI_00669 3.1e-113 udk 2.7.1.48 F Cytidine monophosphokinase
COIBCLKI_00670 0.0 uup S abc transporter atp-binding protein
COIBCLKI_00671 4e-150 sufB O assembly protein SufB
COIBCLKI_00672 2.3e-311 oppA E ABC transporter substrate-binding protein
COIBCLKI_00673 9.7e-161 oppB P ABC-type dipeptide oligopeptide nickel transport systems, permease components
COIBCLKI_00674 1.9e-165 oppC EP ABC-type dipeptide oligopeptide nickel transport systems, permease components
COIBCLKI_00675 1.9e-197 oppD P Belongs to the ABC transporter superfamily
COIBCLKI_00676 4.1e-167 oppF P Belongs to the ABC transporter superfamily
COIBCLKI_00677 8e-26
COIBCLKI_00678 4.3e-158 hslO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
COIBCLKI_00679 9.4e-77 K TetR family transcriptional regulator
COIBCLKI_00680 7.6e-82 Q Methyltransferase domain
COIBCLKI_00681 3.9e-122 ybbA S Putative esterase
COIBCLKI_00682 1e-171 fatB P COG0614 ABC-type Fe3 -hydroxamate transport system, periplasmic component
COIBCLKI_00683 4.9e-134 fecE 3.6.3.34 HP ABC transporter
COIBCLKI_00684 1.4e-155 fecD P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
COIBCLKI_00685 5.4e-125 V CAAX protease self-immunity
COIBCLKI_00686 5.6e-155 S Domain of unknown function (DUF4300)
COIBCLKI_00687 4.3e-191 M family 8
COIBCLKI_00688 3.7e-25
COIBCLKI_00691 5e-69 yhaI J Protein of unknown function (DUF805)
COIBCLKI_00692 4.3e-65 yhaI S Protein of unknown function (DUF805)
COIBCLKI_00693 1.5e-225 proA 1.2.1.41 E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
COIBCLKI_00694 5.2e-142 proB 2.7.2.11 E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
COIBCLKI_00695 2.1e-272 XK27_00765
COIBCLKI_00696 3.4e-132 ecsA_2 V abc transporter atp-binding protein
COIBCLKI_00697 1.4e-125 S Protein of unknown function (DUF554)
COIBCLKI_00698 7.8e-92 yvbG U UPF0056 membrane protein
COIBCLKI_00699 0.0 gidA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
COIBCLKI_00700 0.0 yybT T signaling protein consisting of a modified GGDEF domain and a DHH domain
COIBCLKI_00701 2.2e-73 rplI J binds to the 23S rRNA
COIBCLKI_00702 1e-246 dnaB 3.6.4.12 L Participates in initiation and elongation during chromosome replication
COIBCLKI_00703 1.8e-47 veg S Biofilm formation stimulator VEG
COIBCLKI_00704 5.8e-109 rpsD J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
COIBCLKI_00705 9.6e-53 sip L Belongs to the 'phage' integrase family
COIBCLKI_00706 2.4e-16 atpE C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
COIBCLKI_00707 9e-122 atpB C it plays a direct role in the translocation of protons across the membrane
COIBCLKI_00708 1.6e-77 atpF C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
COIBCLKI_00709 1e-85 atpH C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
COIBCLKI_00710 3.4e-280 atpA 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
COIBCLKI_00711 4.8e-157 atpG C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
COIBCLKI_00712 7.9e-263 atpD 3.6.3.14 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
COIBCLKI_00713 2.6e-68 atpC C Produces ATP from ADP in the presence of a proton gradient across the membrane
COIBCLKI_00714 5.1e-216 ftsW D Belongs to the SEDS family
COIBCLKI_00715 1.4e-77 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
COIBCLKI_00716 6.3e-35 XK27_09805 S MORN repeat protein
COIBCLKI_00717 0.0 XK27_09800 I Acyltransferase
COIBCLKI_00718 3e-187 ruvB 3.6.4.12 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
COIBCLKI_00719 2.9e-48 rpsJ J Involved in the binding of tRNA to the ribosomes
COIBCLKI_00720 2.6e-109 rplC J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
COIBCLKI_00721 5.7e-104 rplD J Forms part of the polypeptide exit tunnel
COIBCLKI_00722 2.4e-44 rplW J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
COIBCLKI_00723 6.8e-153 rplB J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
COIBCLKI_00724 2.9e-47 rpsS J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
COIBCLKI_00725 6.9e-51 rplV J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
COIBCLKI_00726 4.3e-81 ssb L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
COIBCLKI_00727 1.7e-35 rpsR J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
COIBCLKI_00729 2.6e-123 XK27_01040 S Protein of unknown function (DUF1129)
COIBCLKI_00730 1e-168 corA P COG0598 Mg2 and Co2 transporters
COIBCLKI_00731 0.0 uvrA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
COIBCLKI_00735 0.0 amiA E ABC transporter, substrate-binding protein, family 5
COIBCLKI_00736 3.5e-274 gltX 6.1.1.17, 6.1.1.24 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
COIBCLKI_00737 6.7e-232 2.7.13.3 T signal transduction protein with a C-terminal ATPase domain
COIBCLKI_00738 3.5e-155 hpk9 2.7.13.3 T protein histidine kinase activity
COIBCLKI_00739 7.3e-207 hpk9 2.7.13.3 T protein histidine kinase activity
COIBCLKI_00740 4.1e-181 ldh 1.1.1.27 C Belongs to the LDH MDH superfamily. LDH family
COIBCLKI_00741 0.0 gyrA 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
COIBCLKI_00742 6e-132 srtA 3.4.22.70 M Sortase (surface protein transpeptidase)
COIBCLKI_00743 2e-70 yaeR E COG0346 Lactoylglutathione lyase and related lyases
COIBCLKI_00744 5.8e-164 ypuA S secreted protein
COIBCLKI_00745 3.6e-230 mntH P Mn2 and Fe2 transporters of the NRAMP family
COIBCLKI_00746 4.4e-45 rpmE2 J 50S ribosomal protein L31
COIBCLKI_00747 3.5e-52 WQ51_03320 S cog cog4835
COIBCLKI_00748 2.4e-150 XK27_08360 S EDD domain protein, DegV family
COIBCLKI_00749 1.3e-137 dapB 1.17.1.8 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
COIBCLKI_00750 3e-218 cca 2.7.7.19, 2.7.7.72 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
COIBCLKI_00751 0.0 yfmR S abc transporter atp-binding protein
COIBCLKI_00752 1.3e-26 U response to pH
COIBCLKI_00753 1.6e-129 3.6.1.13, 3.6.1.55 F AdP-ribose pyrophosphatase
COIBCLKI_00754 6.5e-204 nadD 2.7.1.22, 2.7.7.1, 2.7.7.18, 3.6.1.55 H adenylyltransferase
COIBCLKI_00755 4.6e-45 rplL J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
COIBCLKI_00756 1.9e-78 rplJ J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
COIBCLKI_00757 1.1e-201 V permease protein
COIBCLKI_00758 4.4e-121 macB V ABC transporter, ATP-binding protein
COIBCLKI_00759 2.6e-180 acrA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
COIBCLKI_00760 4.7e-129 2.1.1.223 S Putative SAM-dependent methyltransferase
COIBCLKI_00761 0.0 carB 6.3.5.5 F carbamoyl-phosphate synthetase ammonia chain
COIBCLKI_00762 0.0 pbp1B 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
COIBCLKI_00763 1.9e-239 tyrS 6.1.1.1 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
COIBCLKI_00764 3e-195 ilvC 1.1.1.86 H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
COIBCLKI_00765 2.2e-76 ilvN 2.2.1.6 E Acetolactate synthase
COIBCLKI_00766 0.0 ilvB 2.2.1.6 EH Acetolactate synthase
COIBCLKI_00767 7.9e-44 yoeB S Addiction module toxin, Txe YoeB family
COIBCLKI_00768 7.6e-39 yefM 2.3.1.15 D Antitoxin component of a toxin-antitoxin (TA) module
COIBCLKI_00769 1.3e-196 ylbM S Belongs to the UPF0348 family
COIBCLKI_00770 1.3e-139 yqeM Q Methyltransferase domain protein
COIBCLKI_00771 2e-58 rsfS J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
COIBCLKI_00772 4e-107 nadD 2.7.6.3, 2.7.7.18 H HD superfamily hydrolase involved in NAD metabolism
COIBCLKI_00773 1.2e-117 nadD 2.7.7.18, 3.6.1.55 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
COIBCLKI_00774 7.7e-49 yhbY J RNA-binding protein
COIBCLKI_00775 4.6e-213 yqeH S in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis
COIBCLKI_00776 3e-98 yqeG S hydrolase of the HAD superfamily
COIBCLKI_00777 0.0 2.4.1.5 GH13 M KxYKxGKxW signal domain protein
COIBCLKI_00778 6e-240 S dextransucrase activity
COIBCLKI_00779 4.2e-235 nylA 3.5.1.4 J Belongs to the amidase family
COIBCLKI_00780 1.7e-111 pyrE 2.4.2.10, 4.1.1.23 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
COIBCLKI_00781 5.3e-127 pyrF 4.1.1.23 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
COIBCLKI_00782 4.5e-177 pyrD 1.3.1.14, 1.3.98.1 F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
COIBCLKI_00783 1.3e-145 pyrK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )
COIBCLKI_00784 2.9e-96 thiJ 2.7.11.1, 3.5.1.124 S DJ-1 family
COIBCLKI_00785 1.8e-142 S TraX protein
COIBCLKI_00786 0.0 2.4.1.5 GH13 M KxYKxGKxW signal domain protein
COIBCLKI_00787 6e-121 yhfC S Putative membrane peptidase family (DUF2324)
COIBCLKI_00788 1.1e-43 czrA K helix_turn_helix, Arsenical Resistance Operon Repressor
COIBCLKI_00789 1.2e-15 S integral membrane protein
COIBCLKI_00790 5.2e-47 mccF V LD-carboxypeptidase
COIBCLKI_00791 3.9e-72 badR K Transcriptional regulator, marr family
COIBCLKI_00792 1.2e-35 XK27_02060 S Transglycosylase associated protein
COIBCLKI_00793 1.5e-236 pepS E COG2309 Leucyl aminopeptidase (aminopeptidase T)
COIBCLKI_00794 0.0 polC 2.7.7.7 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
COIBCLKI_00800 1.9e-107 S Domain of Unknown Function with PDB structure (DUF3862)
COIBCLKI_00801 8.4e-117 M Pfam SNARE associated Golgi protein
COIBCLKI_00802 3.4e-29 murN 2.3.2.16 V FemAB family
COIBCLKI_00803 7.2e-189 murN 2.3.2.16 V FemAB family
COIBCLKI_00804 2.3e-173 S oxidoreductase
COIBCLKI_00805 6.2e-48 XK27_09445 S Domain of unknown function (DUF1827)
COIBCLKI_00806 4.8e-84 mutT 3.5.4.33, 3.6.1.13, 3.6.1.55 L Belongs to the Nudix hydrolase family
COIBCLKI_00807 0.0 clpE O Belongs to the ClpA ClpB family
COIBCLKI_00808 6.7e-73 S Psort location CytoplasmicMembrane, score
COIBCLKI_00809 1.6e-126 sitB 3.6.3.35 P ABC transporter, ATP-binding protein
COIBCLKI_00810 3.8e-135 mtsC P ABC-type Mn2 Zn2 transport systems, permease components
COIBCLKI_00811 1.5e-172 sitA P Belongs to the bacterial solute-binding protein 9 family
COIBCLKI_00812 1e-119 sirR K iron dependent repressor
COIBCLKI_00813 4e-135 htpX O Belongs to the peptidase M48B family
COIBCLKI_00814 1.2e-92 lemA S LemA family
COIBCLKI_00815 4e-176 spd F DNA RNA non-specific endonuclease
COIBCLKI_00816 4.1e-98 mvaS 2.3.3.10 I synthase
COIBCLKI_00817 9.5e-223 mvaA 1.1.1.34, 1.1.1.88, 2.3.1.9 C Belongs to the HMG-CoA reductase family
COIBCLKI_00818 8.6e-78 K hmm pf08876
COIBCLKI_00819 5.2e-119 yqfA K protein, Hemolysin III
COIBCLKI_00820 4.1e-29 pspC KT PspC domain protein
COIBCLKI_00821 4.4e-197 S Protein of unknown function (DUF3114)
COIBCLKI_00822 1.8e-170 S hydrolases or acyltransferases (alpha beta hydrolase superfamily)
COIBCLKI_00823 1.5e-302 thrS 6.1.1.3 J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
COIBCLKI_00825 1e-57 arsC 1.20.4.1 P Belongs to the ArsC family
COIBCLKI_00826 7.8e-72 ogt 2.1.1.63, 3.2.2.20 L methylated-DNA-[protein]-cysteine S-methyltransferase activity
COIBCLKI_00827 1.4e-220 serA 1.1.1.399, 1.1.1.95 EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
COIBCLKI_00828 5.1e-104 wecD M Acetyltransferase (GNAT) domain
COIBCLKI_00829 3e-209 serC 2.6.1.52 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
COIBCLKI_00830 4.7e-160 GK ROK family
COIBCLKI_00831 1.8e-71 gloA 4.4.1.5 E Lactoylglutathione lyase
COIBCLKI_00832 1.9e-145 XK27_08050 O HflC and HflK could regulate a protease
COIBCLKI_00833 9.1e-42 WQ51_02910 S Protein of unknown function, DUF536
COIBCLKI_00834 8.2e-63 XK27_02560 S cog cog2151
COIBCLKI_00835 0.0 ilvD 4.2.1.9 E Belongs to the IlvD Edd family
COIBCLKI_00836 4.7e-224 ytfP S Flavoprotein
COIBCLKI_00838 2.6e-120 trmB 2.1.1.297, 2.1.1.33 J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
COIBCLKI_00839 7.1e-152 ytmP 2.7.1.89 M Phosphotransferase
COIBCLKI_00840 2.2e-102 1.6.5.2 S NADPH-quinone reductase (modulator of drug activity B)
COIBCLKI_00841 8.4e-105 K Transcriptional regulator
COIBCLKI_00842 1.6e-151 jag S RNA-binding protein
COIBCLKI_00843 8.2e-146 yidC U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
COIBCLKI_00844 3.8e-54 rnpA 3.1.26.5 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
COIBCLKI_00845 2.4e-264 argH 4.3.2.1 E Argininosuccinate lyase
COIBCLKI_00846 5.8e-230 argG 6.3.4.5 E Belongs to the argininosuccinate synthase family. Type 1 subfamily
COIBCLKI_00847 0.0 dinG 2.7.7.7, 3.6.4.12 L helicase involved in DNA repair and perhaps also replication
COIBCLKI_00848 1.1e-81 ypmB S Protein conserved in bacteria
COIBCLKI_00849 1.8e-212 aspB 2.6.1.1, 2.6.1.14 E Aminotransferase
COIBCLKI_00850 8.4e-262 asnS 6.1.1.22 J Catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
COIBCLKI_00851 4.2e-56 ywlC 2.7.7.87, 3.1.3.48 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
COIBCLKI_00852 2.7e-230 glyA 2.1.2.1 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
COIBCLKI_00853 1.9e-178 ndpA S 37-kD nucleoid-associated bacterial protein
COIBCLKI_00854 1.9e-99 pvaA M lytic transglycosylase activity
COIBCLKI_00855 1.7e-291 yfiB1 V abc transporter atp-binding protein
COIBCLKI_00856 1.2e-143 hom 1.1.1.3, 2.7.2.4 E homoserine dehydrogenase
COIBCLKI_00857 2.7e-152 thrB 2.7.1.39 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
COIBCLKI_00858 1.7e-149 rarD S Transporter
COIBCLKI_00859 6.8e-17 T peptidase
COIBCLKI_00860 3e-14 coiA 3.6.4.12 S Competence protein
COIBCLKI_00861 1.5e-106 S COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
COIBCLKI_00862 7.7e-108 rimL 2.3.1.128, 5.2.1.8 J COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
COIBCLKI_00863 4.2e-175 S Helix-hairpin-helix DNA-binding motif class 1
COIBCLKI_00864 3e-38 ptsH G phosphocarrier protein Hpr
COIBCLKI_00865 9.7e-222 icd 1.1.1.42 C Isocitrate dehydrogenase
COIBCLKI_00866 2.5e-211 citZ 2.3.3.1 C Belongs to the citrate synthase family
COIBCLKI_00867 0.0 acnA 4.2.1.3 C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
COIBCLKI_00868 1.7e-117 mtnN 3.2.2.9 E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
COIBCLKI_00869 2.9e-25
COIBCLKI_00870 1e-96 nudF 3.6.1.13 L AdP-ribose pyrophosphatase
COIBCLKI_00871 2.1e-255 glmU 2.3.1.157, 2.7.7.23 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
COIBCLKI_00872 0.0 mgtA 3.6.3.2 P COG0474 Cation transport ATPase
COIBCLKI_00873 1.3e-274 lmrA2 V abc transporter atp-binding protein
COIBCLKI_00874 3.3e-112 K Acetyltransferase (GNAT) family
COIBCLKI_00875 5.1e-113 2.7.6.5 S Region found in RelA / SpoT proteins
COIBCLKI_00876 4.4e-118 T response regulator
COIBCLKI_00877 4.4e-217 sptS 2.7.13.3 T Histidine kinase
COIBCLKI_00878 1.7e-131 pyrH 2.7.4.22 F Catalyzes the reversible phosphorylation of UMP to UDP
COIBCLKI_00879 1.7e-91 frr J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
COIBCLKI_00880 1.6e-36 yneF S UPF0154 protein
COIBCLKI_00881 1.5e-149 murI 5.1.1.3 M Provides the (R)-glutamate required for cell wall biosynthesis
COIBCLKI_00882 3.2e-186 rdgB 3.6.1.66, 5.1.1.3 F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
COIBCLKI_00883 3.9e-98 XK27_09740 S Phosphoesterase
COIBCLKI_00884 8.3e-87 ykuL S CBS domain
COIBCLKI_00885 1e-134 xerD L tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site
COIBCLKI_00886 1.8e-122 scpA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
COIBCLKI_00887 1.7e-94 scpB D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
COIBCLKI_00888 3.4e-132 rluB 5.4.99.19, 5.4.99.21, 5.4.99.22 J Belongs to the pseudouridine synthase RsuA family
COIBCLKI_00889 1.4e-13 yidD M Could be involved in insertion of integral membrane proteins into the membrane
COIBCLKI_00890 2.4e-308 asp1 S Accessory Sec system protein Asp1
COIBCLKI_00891 1.5e-302 asp2 3.4.11.5 S Accessory Sec system protein Asp2
COIBCLKI_00892 1.1e-67 asp3 S Accessory Sec system protein Asp3
COIBCLKI_00893 0.0 secA2 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
COIBCLKI_00894 1.1e-12 S Accessory secretory protein Sec Asp4
COIBCLKI_00895 7e-12 S Accessory secretory protein Sec, Asp5
COIBCLKI_00896 0.0 lmrA1 V abc transporter atp-binding protein
COIBCLKI_00897 3.3e-74 K DNA-binding transcription factor activity
COIBCLKI_00898 4.6e-70 def_1 3.5.1.31, 3.5.1.88 J Removes the formyl group from the N-terminal Met of newly synthesized proteins
COIBCLKI_00899 1.4e-279 S Psort location CytoplasmicMembrane, score
COIBCLKI_00900 1.5e-255 gdhA 1.4.1.4 E Belongs to the Glu Leu Phe Val dehydrogenases family
COIBCLKI_00901 0.0 lpdA 1.8.1.4 C Dehydrogenase
COIBCLKI_00902 1.8e-198 acoC 2.3.1.12 C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
COIBCLKI_00903 6.4e-182 acoB 1.2.4.1, 1.2.4.4 C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
COIBCLKI_00904 7.8e-185 acoA 1.2.4.1, 1.2.4.4 C Dehydrogenase E1 component
COIBCLKI_00905 1.4e-110 hsdS2 2.1.1.72 V Type I restriction modification DNA specificity domain
COIBCLKI_00906 4.7e-35 M1-755 S Domain of unknown function (DUF1858)
COIBCLKI_00907 4.5e-247 XK27_04775 S hemerythrin HHE cation binding domain
COIBCLKI_00908 4.8e-146 truB 5.4.99.25 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
COIBCLKI_00909 1.2e-171 ribF 2.7.1.26, 2.7.7.2 H Belongs to the ribF family
COIBCLKI_00910 1.6e-70 spxA 1.20.4.1 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
COIBCLKI_00911 5.1e-44 yktA S Belongs to the UPF0223 family
COIBCLKI_00912 6.5e-142 suhB 3.1.3.25 G Belongs to the inositol monophosphatase superfamily
COIBCLKI_00913 0.0 gshF 6.3.2.2, 6.3.2.29, 6.3.2.30, 6.3.2.4 H Belongs to the glutamate--cysteine ligase type 1 family
COIBCLKI_00915 5e-287 S Protein of unknown function (DUF3114)
COIBCLKI_00916 2.5e-98 2.3.1.128 K Acetyltransferase GNAT Family
COIBCLKI_00917 1.4e-78 glgP 2.4.1.1 GT35 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
COIBCLKI_00918 1.2e-112 serB 3.1.3.3 E phosphoserine phosphatase
COIBCLKI_00919 5.1e-304 ezrA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
COIBCLKI_00920 0.0 gyrB 5.99.1.3 L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
COIBCLKI_00921 4.6e-97 3.1.3.18 S IA, variant 1
COIBCLKI_00922 1.6e-115 lrgB M Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like proteins CidA and or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses
COIBCLKI_00923 3.5e-56 lrgA S Effector of murein hydrolase LrgA
COIBCLKI_00924 1.7e-307 M family 8
COIBCLKI_00925 2e-147 epsH S acetyltransferase'
COIBCLKI_00926 1.1e-233 M Glycosyltransferase, family 8
COIBCLKI_00927 1.9e-286 tagE 2.4.1.52 GT4 M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
COIBCLKI_00929 0.0 metG 6.1.1.10, 6.1.1.20 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
COIBCLKI_00930 2.1e-162 S reductase
COIBCLKI_00931 4.7e-168 K transcriptional regulator (lysR family)
COIBCLKI_00932 2.7e-105 S CAAX amino terminal protease family protein
COIBCLKI_00933 5.5e-29 S Antitoxin component of a toxin-antitoxin (TA) module
COIBCLKI_00934 2e-48 doc S Fic/DOC family
COIBCLKI_00935 0.0 mdlB V abc transporter atp-binding protein
COIBCLKI_00936 0.0 lmrA V abc transporter atp-binding protein
COIBCLKI_00937 3e-198 queA 2.4.99.17 J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
COIBCLKI_00938 2.5e-36 cpdB 3.1.3.6, 3.1.4.16 F Belongs to the 5'-nucleotidase family
COIBCLKI_00939 3.2e-130 rsmE 2.1.1.193 J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
COIBCLKI_00940 1.2e-177 prmA J Ribosomal protein L11 methyltransferase
COIBCLKI_00941 2.1e-82 XK27_02675 K Acetyltransferase GNAT Family
COIBCLKI_00942 2.1e-70 mutT3 3.6.1.13, 3.6.1.55 L NUDIX domain
COIBCLKI_00943 3.2e-83 XK27_03960 S Protein of unknown function (DUF3013)
COIBCLKI_00944 2.4e-308 pyrG 6.3.4.2 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
COIBCLKI_00945 2.5e-39 rpoE K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
COIBCLKI_00946 9e-156 pstS P phosphate
COIBCLKI_00947 2.5e-156 pstC P probably responsible for the translocation of the substrate across the membrane
COIBCLKI_00948 1.5e-155 pstA P phosphate transport system permease
COIBCLKI_00949 4e-150 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
COIBCLKI_00950 3.9e-139 pstB 3.6.3.27 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
COIBCLKI_00951 3.2e-113 phoU P Plays a role in the regulation of phosphate uptake
COIBCLKI_00952 6.6e-08
COIBCLKI_00953 0.0 feoB P transporter of a GTP-driven Fe(2 ) uptake system
COIBCLKI_00954 3.1e-78 feoA P FeoA domain protein
COIBCLKI_00955 9.3e-130 glnQ 3.6.3.21 E abc transporter atp-binding protein
COIBCLKI_00956 1.3e-117 WQ51_01820 P Binding-protein-dependent transport system inner membrane component
COIBCLKI_00957 1e-34 ykuJ S protein conserved in bacteria
COIBCLKI_00958 1.1e-181 argF 2.1.3.3 E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
COIBCLKI_00959 6.2e-120 yoaK S Protein of unknown function (DUF1275)
COIBCLKI_00960 4.8e-85 rlmH 2.1.1.177 J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
COIBCLKI_00961 9.2e-207 htrA 3.4.21.107 O Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain'
COIBCLKI_00962 5e-134 parB K Belongs to the ParB family
COIBCLKI_00963 1e-254 dnaA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
COIBCLKI_00964 0.0 2.4.1.21 GT5 M Right handed beta helix region
COIBCLKI_00965 6.7e-159 S double-stranded DNA endodeoxyribonuclease activity
COIBCLKI_00966 6.5e-196 higA K Pfam:DUF955
COIBCLKI_00967 6.1e-192 XK27_10075 S abc transporter atp-binding protein
COIBCLKI_00968 0.0 V abc transporter atp-binding protein
COIBCLKI_00969 5.2e-296 V abc transporter atp-binding protein
COIBCLKI_00970 2.1e-132 glcR K transcriptional regulator (DeoR family)
COIBCLKI_00971 5.8e-149 cof S Sucrose-6F-phosphate phosphohydrolase
COIBCLKI_00972 1.1e-69 3.1.3.27, 3.1.3.4, 3.1.3.81, 3.6.1.27 I phosphatidate phosphatase activity
COIBCLKI_00973 8.4e-96 nusG K Participates in transcription elongation, termination and antitermination
COIBCLKI_00974 2.8e-24 secE U Belongs to the SecE SEC61-gamma family
COIBCLKI_00975 6.2e-20 rpmG J Belongs to the bacterial ribosomal protein bL33 family
COIBCLKI_00976 0.0 pbp2A 2.4.1.129, 3.4.16.4 GT51 M penicillin-binding protein
COIBCLKI_00977 9.1e-30 dhaK 2.7.1.121, 2.7.1.28, 2.7.1.29, 4.6.1.15 G Dihydroxyacetone kinase
COIBCLKI_00978 3.8e-94 dhaL 2.7.1.121 S Dihydroxyacetone kinase
COIBCLKI_00979 6.3e-58 dhaM 2.7.1.121 S dihydroxyacetone kinase, phosphotransfer subunit
COIBCLKI_00980 4.7e-177 XK27_10475 S oxidoreductase
COIBCLKI_00981 6.7e-193 gldA 1.1.1.6 C glycerol dehydrogenase
COIBCLKI_00983 7.3e-283 XK27_07020 S Belongs to the UPF0371 family
COIBCLKI_00984 1.3e-167 cpsJ M Glycosyltransferase group 2 family protein
COIBCLKI_00985 0.0 M cog cog1442
COIBCLKI_00986 8.9e-242 M family 8
COIBCLKI_00987 9.9e-65 secY2 U Part of the accessory SecA2 SecY2 system specifically required for export of
COIBCLKI_00988 4.9e-25 XK27_07105 K transcriptional
COIBCLKI_00989 1.8e-26
COIBCLKI_00990 8.2e-108 XK27_02070 S nitroreductase
COIBCLKI_00991 7.9e-149 1.13.11.2 S glyoxalase
COIBCLKI_00992 4.7e-76 ywnA K Transcriptional regulator
COIBCLKI_00993 2.2e-154 E Alpha/beta hydrolase of unknown function (DUF915)
COIBCLKI_00994 1.1e-206 pts13C G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
COIBCLKI_00995 5.6e-261 XK27_03190 5.2.1.8 S hydrolases of the HAD superfamily
COIBCLKI_00996 1.5e-110 yebC M Membrane
COIBCLKI_00997 7.8e-297 KT response to antibiotic
COIBCLKI_00998 6.8e-75 XK27_02470 K LytTr DNA-binding domain protein
COIBCLKI_00999 4e-248 mgs 2.4.1.337 GT4 M Glycosyltransferase, group 1 family protein
COIBCLKI_01000 2.3e-192 dgs 2.4.1.208 GT4 M Glycosyltransferase, group 1 family protein
COIBCLKI_01001 0.0 U protein secretion
COIBCLKI_01002 9.5e-112 ureG KO Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
COIBCLKI_01003 5.3e-130 ureF O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
COIBCLKI_01004 6.6e-78 ureE O enzyme active site formation
COIBCLKI_01005 0.0 ureC 3.5.1.5 E Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family
COIBCLKI_01006 7.8e-54 ureB 3.5.1.5 E Belongs to the urease beta subunit family
COIBCLKI_01007 7.6e-46 ureA 3.5.1.5 E Belongs to the urease gamma subunit family
COIBCLKI_01008 3.4e-94 ureI S AmiS/UreI family transporter
COIBCLKI_01009 4.5e-59 pdxH S pyridoxamine 5'-phosphate oxidase
COIBCLKI_01010 3.8e-224 pbuX F xanthine permease
COIBCLKI_01011 1.3e-97 xpt 2.4.2.22, 2.4.2.7 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
COIBCLKI_01012 5.4e-124 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
COIBCLKI_01013 4.8e-150 T Histidine kinase
COIBCLKI_01014 3.2e-133 macB2 V ABC transporter, ATP-binding protein
COIBCLKI_01015 7.9e-255 cycA E permease
COIBCLKI_01016 2.3e-07 uvrX 2.7.7.7 L impB/mucB/samB family
COIBCLKI_01017 0.0 pts33BCA 2.7.1.201, 2.7.1.208, 2.7.1.211 G pts system
COIBCLKI_01018 9.2e-141 ppiA 5.2.1.8 O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
COIBCLKI_01019 2.3e-173 apbE 2.7.1.180 H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
COIBCLKI_01020 2.9e-176 nrnA 3.1.13.3, 3.1.3.7 S domain protein
COIBCLKI_01021 1.2e-114 gst O Glutathione S-transferase
COIBCLKI_01022 7.6e-183 add 3.5.4.4 F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
COIBCLKI_01023 6.2e-108 tdk 2.7.1.21 F thymidine kinase
COIBCLKI_01024 7e-256 noxE P NADH oxidase
COIBCLKI_01025 1.1e-294 yfmM S abc transporter atp-binding protein
COIBCLKI_01026 4.3e-84 XK27_01265 S ECF-type riboflavin transporter, S component
COIBCLKI_01027 2.4e-153 pdxK 2.7.1.35 H Belongs to the pyridoxine kinase family
COIBCLKI_01028 2.2e-85 S ECF-type riboflavin transporter, S component
COIBCLKI_01030 6e-174 birA 6.3.4.15 HK Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
COIBCLKI_01031 9.8e-305 dnaX 2.7.7.7 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
COIBCLKI_01032 1.5e-86 ytsP 1.8.4.14 T GAF domain-containing protein
COIBCLKI_01033 6.3e-160 miaA 2.5.1.75 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
COIBCLKI_01034 3.2e-20 WQ51_02665 S Protein of unknown function (DUF3042)
COIBCLKI_01036 2.3e-201 oppD P Belongs to the ABC transporter superfamily
COIBCLKI_01037 1.4e-167 amiD P ABC transporter (Permease
COIBCLKI_01038 1.1e-275 amiC P ABC transporter (Permease
COIBCLKI_01039 4e-248 amiA E ABC transporter, substrate-binding protein, family 5
COIBCLKI_01040 0.0 uvrC L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
COIBCLKI_01041 1.3e-128 yjjG 3.1.3.102, 3.1.3.104, 3.1.3.5, 3.8.1.2 E hydrolase
COIBCLKI_01042 1.8e-119 sdaAB 4.3.1.17 E L-serine dehydratase
COIBCLKI_01043 1.5e-147 sdaAA 4.3.1.17 E L-serine dehydratase
COIBCLKI_01044 9.9e-106 S TraX protein
COIBCLKI_01045 1.5e-118 T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
COIBCLKI_01046 4.7e-236 T PhoQ Sensor
COIBCLKI_01047 1.1e-258 trmFO 2.1.1.74 J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
COIBCLKI_01048 5.9e-224 XK27_05470 E Methionine synthase
COIBCLKI_01049 3.4e-310 FbpA K RNA-binding protein homologous to eukaryotic snRNP
COIBCLKI_01050 3.3e-270 S Psort location CytoplasmicMembrane, score
COIBCLKI_01051 8.5e-227 dinF V Mate efflux family protein
COIBCLKI_01052 1.1e-83 yclQ P ABC-type enterochelin transport system, periplasmic component
COIBCLKI_01053 6e-15 rpmJ J Belongs to the bacterial ribosomal protein bL36 family
COIBCLKI_01054 2.7e-32 infA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
COIBCLKI_01055 7.3e-118 adk 2.7.4.3 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
COIBCLKI_01056 2.1e-230 secY U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
COIBCLKI_01057 5.7e-58 rplO J binds to the 23S rRNA
COIBCLKI_01058 1.9e-23 rpmD J ribosomal protein l30
COIBCLKI_01059 1.3e-79 rpsE J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
COIBCLKI_01060 2.5e-56 rplR J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
COIBCLKI_01061 6.6e-93 rplF J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
COIBCLKI_01062 9.7e-32 rpsH J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
COIBCLKI_01063 3.1e-150 S von Willebrand factor (vWF) type A domain
COIBCLKI_01064 0.0 V Type III restriction enzyme, res subunit
COIBCLKI_01065 1.9e-53 glnB K Belongs to the P(II) protein family
COIBCLKI_01066 1.9e-228 amt P Ammonium Transporter
COIBCLKI_01067 4e-156 rsmI 2.1.1.198 H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
COIBCLKI_01068 1.2e-54 yabA L Involved in initiation control of chromosome replication
COIBCLKI_01069 2.2e-132 yaaT S stage 0 sporulation protein
COIBCLKI_01070 3.9e-159 holB 2.7.7.7 L dna polymerase iii
COIBCLKI_01071 9.1e-110 tmk 2.7.4.9 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
COIBCLKI_01073 6.2e-30 acpP1 IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis
COIBCLKI_01074 1.9e-184 plsX 2.3.1.15 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
COIBCLKI_01075 7e-144 recO L Involved in DNA repair and RecF pathway recombination
COIBCLKI_01076 3.8e-218 araT 2.6.1.1 E Aminotransferase
COIBCLKI_01077 9.5e-175 prs 2.7.6.1 F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
COIBCLKI_01079 1.5e-166 fhuR K transcriptional regulator (lysR family)
COIBCLKI_01080 1.3e-76 lspA 3.4.23.36 MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins
COIBCLKI_01081 1.5e-161 rluD 5.4.99.23 J Responsible for synthesis of pseudouridine from uracil
COIBCLKI_01082 4.8e-88 pyrR 2.4.2.9 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
COIBCLKI_01083 0.0 sbcC L ATPase involved in DNA repair
COIBCLKI_01084 9.3e-220 sbcD L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
COIBCLKI_01085 3.2e-124 ftsE D cell division ATP-binding protein FtsE
COIBCLKI_01086 1.3e-182 prfB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
COIBCLKI_01087 1e-204 queG 1.17.99.6 C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
COIBCLKI_01088 2.5e-155 yjjH S Calcineurin-like phosphoesterase
COIBCLKI_01089 9.7e-135 nfrA 1.5.1.38, 1.5.1.39 C nitroreductase
COIBCLKI_01090 3.9e-20 pacL 3.6.3.8 P cation transport ATPase
COIBCLKI_01091 3.9e-125 V abc transporter atp-binding protein
COIBCLKI_01092 0.0 V ABC transporter (Permease
COIBCLKI_01093 2.9e-131 K transcriptional regulator, MerR family
COIBCLKI_01094 3.3e-121 rpiA 2.7.1.12, 2.7.1.15, 5.3.1.6 G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
COIBCLKI_01095 2.5e-253 V Glucan-binding protein C
COIBCLKI_01096 4.8e-137 XK27_05435 1.1.1.100 S Belongs to the short-chain dehydrogenases reductases (SDR) family
COIBCLKI_01097 5.9e-174 rnz 3.1.26.11 S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
COIBCLKI_01098 8.1e-114 galT 2.7.7.12 G UDPglucose--hexose-1-phosphate uridylyltransferase
COIBCLKI_01099 1.1e-245 hflX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
COIBCLKI_01100 1.5e-111 rodA D Belongs to the SEDS family
COIBCLKI_01101 1.2e-97 lepB 3.4.21.89 U Belongs to the peptidase S26 family
COIBCLKI_01102 2.8e-224 G COG0457 FOG TPR repeat
COIBCLKI_01103 3e-178 yubA S permease
COIBCLKI_01104 1.9e-91 mutX 3.6.1.55 F NTP pyrophosphohydrolases including oxidative damage repair enzymes
COIBCLKI_01105 6.8e-251 mmuP E amino acid
COIBCLKI_01106 3.9e-110 engB D Necessary for normal cell division and for the maintenance of normal septation
COIBCLKI_01107 2.6e-225 clpX O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
COIBCLKI_01108 9.7e-22
COIBCLKI_01109 1.4e-92 folA 1.5.1.3, 1.5.1.47, 2.1.1.45, 3.5.4.12 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
COIBCLKI_01110 5.2e-65 thyA 2.1.1.45 F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
COIBCLKI_01111 6.1e-96 trmL 2.1.1.207 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
COIBCLKI_01112 6e-89 ribU U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
COIBCLKI_01113 2.8e-106 bcrC 3.6.1.27 I Membrane-associated phospholipid phosphatase
COIBCLKI_01114 3e-154 K sequence-specific DNA binding
COIBCLKI_01115 2.1e-33
COIBCLKI_01116 2.5e-283 adcA P Belongs to the bacterial solute-binding protein 9 family
COIBCLKI_01117 4.3e-128 adcB P ABC transporter (Permease
COIBCLKI_01118 7.3e-132 adcC 3.6.3.35 P ABC transporter, ATP-binding protein
COIBCLKI_01119 1.8e-72 adcR K transcriptional
COIBCLKI_01120 6.9e-145 rbn E Belongs to the UPF0761 family
COIBCLKI_01121 8.2e-85 ccl S cog cog4708
COIBCLKI_01122 0.0 ligA 6.5.1.2 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
COIBCLKI_01123 7.4e-186 yegS 2.7.1.107 I Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
COIBCLKI_01124 4.5e-120 ung 3.2.2.27 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
COIBCLKI_01125 6.3e-235 pyrC 3.5.2.3 F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
COIBCLKI_01126 0.0 S the current gene model (or a revised gene model) may contain a frame shift
COIBCLKI_01127 6.1e-82 2.7.13.3 T protein histidine kinase activity
COIBCLKI_01128 0.0 3.5.1.28 M domain protein
COIBCLKI_01129 2.3e-300 prfC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
COIBCLKI_01130 1.1e-116 ywaF S Integral membrane protein (intg_mem_TP0381)
COIBCLKI_01131 8.9e-259 murF 6.3.2.10 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
COIBCLKI_01132 1.2e-134 queE 1.97.1.4, 4.3.99.3 H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
COIBCLKI_01133 1.8e-83 queD 4.1.2.50, 4.2.3.12 H synthase
COIBCLKI_01134 1.2e-123 queC 6.3.4.20 F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
COIBCLKI_01135 2.3e-63 tdcF 3.5.99.10 J endoribonuclease L-PSP
COIBCLKI_01136 4.3e-201 pmrB EGP Major facilitator Superfamily
COIBCLKI_01137 0.0 parC 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
COIBCLKI_01138 4.8e-201 ilvE 2.6.1.42 E Aminotransferase
COIBCLKI_01139 4.8e-16 S Protein of unknown function (DUF2969)
COIBCLKI_01140 5.8e-149 supH 3.1.3.102, 3.1.3.104 S Sucrose-6F-phosphate phosphohydrolase
COIBCLKI_01141 3.1e-107 pgm G Belongs to the phosphoglycerate mutase family
COIBCLKI_01142 1.4e-107 G Belongs to the phosphoglycerate mutase family
COIBCLKI_01143 1.5e-106 G Belongs to the phosphoglycerate mutase family
COIBCLKI_01144 3.6e-197 S hmm pf01594
COIBCLKI_01145 9.1e-112 ung2 3.2.2.27 L Uracil-DNA glycosylase
COIBCLKI_01146 2.2e-273 pepV 3.5.1.18 E Dipeptidase
COIBCLKI_01147 4.9e-27 dmpI 5.3.2.6 G Belongs to the 4-oxalocrotonate tautomerase family
COIBCLKI_01148 3.9e-90 yybC
COIBCLKI_01149 4.2e-83 XK27_03610 K Gnat family
COIBCLKI_01150 2.3e-303 guaA 2.3.1.128, 6.3.5.2 F Catalyzes the synthesis of GMP from XMP
COIBCLKI_01151 2.7e-126 gntR1 K transcriptional
COIBCLKI_01152 2e-55 ylxM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
COIBCLKI_01153 3.2e-71 M LysM domain
COIBCLKI_01154 8.4e-23
COIBCLKI_01155 1.5e-174 S hydrolase
COIBCLKI_01156 4.3e-115 pgm6 5.4.2.11, 5.4.2.12 G Phosphoglycerate mutase
COIBCLKI_01157 1e-81 ybaK S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
COIBCLKI_01158 7e-41 XK27_00880 3.4.17.14, 3.5.1.28 M Glycosyl hydrolase, family 25
COIBCLKI_01159 6.8e-37 L Transposase
COIBCLKI_01160 0.0 ileS 6.1.1.5 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
COIBCLKI_01161 3.5e-136 divIVA D Cell division initiation protein
COIBCLKI_01163 0.0 alsS 2.2.1.6 EH Belongs to the TPP enzyme family
COIBCLKI_01164 3e-133 budA 4.1.1.5 H Belongs to the alpha-acetolactate decarboxylase family
COIBCLKI_01165 1.2e-41 C Pyridoxamine 5'-phosphate oxidase
COIBCLKI_01166 2.6e-233 murA 2.5.1.7 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
COIBCLKI_01167 7e-98 XK27_07830 2.3.1.128 J Acetyltransferase GNAT Family
COIBCLKI_01168 1.1e-231 ytoI K transcriptional regulator containing CBS domains
COIBCLKI_01169 1.1e-166 map 3.4.11.18 E Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed
COIBCLKI_01170 2.4e-27 XK27_05745
COIBCLKI_01171 6.1e-229 mutY L A G-specific adenine glycosylase
COIBCLKI_01173 4.8e-07
COIBCLKI_01174 4.5e-202 I acyl-CoA dehydrogenase
COIBCLKI_01175 2e-97 mip S hydroperoxide reductase activity
COIBCLKI_01176 3.1e-250 rumA 2.1.1.190 J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
COIBCLKI_01177 4.3e-220 S membrane
COIBCLKI_01178 2.6e-211 nagA 3.5.1.25 G Belongs to the metallo-dependent hydrolases superfamily. NagA family
COIBCLKI_01179 4.8e-216 nptA P COG1283 Na phosphate symporter
COIBCLKI_01180 1.9e-139 ET ABC transporter
COIBCLKI_01181 1.3e-137 ET Belongs to the bacterial solute-binding protein 3 family
COIBCLKI_01182 1e-212 arcT 2.6.1.1 E Aminotransferase
COIBCLKI_01183 2.7e-135 gltS ET Belongs to the bacterial solute-binding protein 3 family
COIBCLKI_01184 4.9e-39 S granule-associated protein
COIBCLKI_01185 2.4e-284 S unusual protein kinase
COIBCLKI_01186 1.4e-102 estA E Lysophospholipase L1 and related esterases
COIBCLKI_01187 2.7e-157 rssA S Phospholipase, patatin family
COIBCLKI_01188 2.3e-18 3.4.16.4 M Belongs to the peptidase S11 family
COIBCLKI_01189 1.3e-165 tehB 2.1.1.265 PQ tellurite resistance protein tehb
COIBCLKI_01190 2.9e-17 yjdB S Domain of unknown function (DUF4767)
COIBCLKI_01191 2.3e-198 XK27_00915 C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
COIBCLKI_01193 8.4e-177 fatB P ABC-type enterochelin transport system, periplasmic component
COIBCLKI_01194 1.8e-125 yclP 3.6.3.34 P abc transporter atp-binding protein
COIBCLKI_01195 1.2e-156 fatC P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
COIBCLKI_01196 1.8e-128 yclN P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
COIBCLKI_01197 4.3e-239 metY 2.5.1.49 E o-acetylhomoserine
COIBCLKI_01198 0.0 pcrA 3.6.4.12 L ATP-dependent DNA helicase
COIBCLKI_01199 2.8e-157 XK27_09825 V abc transporter atp-binding protein
COIBCLKI_01200 1.4e-15 liaI KT membrane
COIBCLKI_01201 3.8e-29 liaI KT membrane
COIBCLKI_01202 6.1e-93 XK27_05000 S metal cluster binding
COIBCLKI_01203 8e-77 V ABC transporter (permease)
COIBCLKI_01204 5.3e-248 dacA1 3.4.16.4 M Belongs to the peptidase S11 family
COIBCLKI_01205 1.9e-217 yeaB K Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
COIBCLKI_01206 2.3e-190 ddl 6.3.2.4 F Belongs to the D-alanine--D-alanine ligase family
COIBCLKI_01207 9e-20 S peptidase inhibitor activity
COIBCLKI_01208 6.3e-138 ET ABC transporter substrate-binding protein
COIBCLKI_01209 1.4e-130 cbiO P ABC transporter
COIBCLKI_01210 1.1e-136 P cobalt transport protein
COIBCLKI_01211 1.3e-176 cbiM P biosynthesis protein CbiM
COIBCLKI_01212 3e-87 S Fusaric acid resistance protein-like
COIBCLKI_01213 2.5e-62 glnR K Transcriptional regulator
COIBCLKI_01214 5.2e-264 glnA 6.3.1.2 E glutamine synthetase
COIBCLKI_01215 3.3e-115 pscB M CHAP domain protein
COIBCLKI_01216 5.1e-22 K Transcriptional
COIBCLKI_01218 4.1e-153 degV S DegV family
COIBCLKI_01219 6e-91 yacP S RNA-binding protein containing a PIN domain
COIBCLKI_01220 9.7e-135 trmH 2.1.1.185 J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
COIBCLKI_01222 3e-27 nnrD 4.2.1.136, 5.1.99.6 H Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
COIBCLKI_01223 0.0 pbp2b 3.4.16.4 M penicillin-binding protein
COIBCLKI_01224 1.3e-105 recR L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
COIBCLKI_01225 2.8e-191 phoH T phosphate starvation-inducible protein PhoH
COIBCLKI_01226 6e-137 sip M LysM domain protein
COIBCLKI_01227 3.7e-34 yozE S Belongs to the UPF0346 family
COIBCLKI_01228 1.8e-144 cvfB S Protein conserved in bacteria
COIBCLKI_01229 2.2e-148 ycgQ S TIGR03943 family
COIBCLKI_01230 1e-154 XK27_03015 S permease
COIBCLKI_01232 0.0 glgP 2.4.1.1 GT35 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
COIBCLKI_01233 1.8e-228 malQ 2.4.1.25 GH77 G 4-alpha-glucanotransferase
COIBCLKI_01234 2e-146 yidA S hydrolases of the HAD superfamily
COIBCLKI_01235 1.7e-159 XK27_00115 2.3.1.128 K Acetyltransferase GNAT family
COIBCLKI_01236 2.6e-62 rplQ J ribosomal protein l17
COIBCLKI_01237 1.8e-170 rpoA 2.7.7.6 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
COIBCLKI_01238 2.1e-61 rpsK J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
COIBCLKI_01239 6.2e-58 rpsM J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
COIBCLKI_01241 1.6e-68 ytxH S General stress protein
COIBCLKI_01242 3.7e-08 WQ51_05790 S protein containing a divergent version of the methyl-accepting chemotaxis-like domain
COIBCLKI_01243 9.6e-149 lgt 2.1.1.199 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
COIBCLKI_01244 8e-171 hprK F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
COIBCLKI_01245 2.2e-41 pspC KT PspC domain
COIBCLKI_01246 2.1e-120 dus J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
COIBCLKI_01247 1e-70 adcR K transcriptional
COIBCLKI_01248 9.2e-135 adcC P ABC transporter, ATP-binding protein
COIBCLKI_01249 1.3e-127 adcB P ABC transporter (Permease
COIBCLKI_01250 0.0 sasH 3.1.3.5, 3.6.1.45 F Belongs to the 5'-nucleotidase family
COIBCLKI_01251 6.6e-170 bglC K Transcriptional regulator
COIBCLKI_01252 3.7e-258 S dextransucrase activity
COIBCLKI_01253 2.1e-82 btuE 1.11.1.9 O Belongs to the glutathione peroxidase family
COIBCLKI_01254 2e-42 S Sugar efflux transporter for intercellular exchange
COIBCLKI_01255 1.5e-77 P FtsX-like permease family
COIBCLKI_01256 2.7e-31 copZ 2.7.7.77 P Heavy metal-associated domain protein
COIBCLKI_01257 0.0 copA 3.6.3.54 P P-type ATPase
COIBCLKI_01258 2.1e-73 copY K negative regulation of transcription, DNA-templated
COIBCLKI_01259 1.5e-33 ykzG S Belongs to the UPF0356 family
COIBCLKI_01260 3.5e-115 yeaZ 2.3.1.234 O COG1214, inactive homolog of metal-dependent proteases
COIBCLKI_01261 7.6e-71 rimI 2.3.1.128 K This enzyme acetylates the N-terminal alanine of ribosomal protein S18
COIBCLKI_01262 1.5e-228 tig D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
COIBCLKI_01263 5.8e-138 ykuT M mechanosensitive ion channel
COIBCLKI_01264 5.9e-88 sigH K DNA-templated transcription, initiation
COIBCLKI_01265 9.4e-121 T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
COIBCLKI_01266 0.0 fhs 6.3.4.3 F Belongs to the formate--tetrahydrofolate ligase family
COIBCLKI_01267 3e-114 papP P ABC transporter (Permease
COIBCLKI_01268 3e-106 P ABC transporter (Permease
COIBCLKI_01269 5.2e-136 glnQ 3.6.3.21 E abc transporter atp-binding protein
COIBCLKI_01270 3.3e-155 cjaA ET ABC transporter substrate-binding protein
COIBCLKI_01271 3.1e-56 dltA 6.1.1.13 Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
COIBCLKI_01272 6.6e-237 dltB M Membrane protein involved in D-alanine export
COIBCLKI_01273 2.2e-35 dltC 6.1.1.13 IQ Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
COIBCLKI_01274 3e-245 dltD M Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
COIBCLKI_01275 4.6e-152 sdaAA 4.3.1.17 E L-serine dehydratase
COIBCLKI_01276 8.5e-122 sdaAB 4.3.1.17 E L-serine dehydratase
COIBCLKI_01277 1.4e-74 lytE M LysM domain protein
COIBCLKI_01278 2.4e-184 adhB 1.1.1.1, 1.1.1.14 E Zinc-binding dehydrogenase
COIBCLKI_01279 3.7e-191 hemH 4.99.1.1, 4.99.1.9 H Catalyzes the ferrous insertion into protoporphyrin IX
COIBCLKI_01280 5.2e-119 czcD P cation diffusion facilitator family transporter
COIBCLKI_01281 0.0 ppc 4.1.1.31 H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
COIBCLKI_01282 7.2e-200 yyaQ S YjbR
COIBCLKI_01283 1.9e-181 ccpA K Catabolite control protein A
COIBCLKI_01284 0.0 topA 5.99.1.2 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
COIBCLKI_01285 1.1e-71 dprA LU DNA protecting protein DprA
COIBCLKI_01286 0.0 nrdE 1.17.4.1 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
COIBCLKI_01287 2.6e-112 3.4.17.14, 3.5.1.28 NU amidase activity
COIBCLKI_01288 2e-81 S Bacterial inner membrane protein
COIBCLKI_01289 1.4e-107 XK27_04800 S Sucrose-6F-phosphate phosphohydrolase
COIBCLKI_01290 9.5e-124 ftsZ D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
COIBCLKI_01291 1e-122 ylmE S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
COIBCLKI_01292 3.2e-101 sepF D cell septum assembly
COIBCLKI_01293 6.5e-30 yggT D integral membrane protein
COIBCLKI_01294 1.8e-243 mnmE S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
COIBCLKI_01295 4.3e-242 agcS E (Alanine) symporter
COIBCLKI_01296 1e-223 nagA 3.5.1.25 G Belongs to the metallo-dependent hydrolases superfamily. NagA family
COIBCLKI_01297 6.8e-216 XK27_09800 M Acyltransferase family
COIBCLKI_01298 5.2e-44 esxA S protein secretion by the type VII secretion system
COIBCLKI_01299 2.9e-76 purE 5.4.99.18 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
COIBCLKI_01300 3.3e-200 purK 6.3.4.18 F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
COIBCLKI_01301 1.7e-176 1.1.1.169 H Ketopantoate reductase
COIBCLKI_01302 3.3e-33
COIBCLKI_01303 2.2e-73 dtd J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
COIBCLKI_01304 0.0 relA 2.7.6.5 KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
COIBCLKI_01305 4.8e-174 yfjR K regulation of single-species biofilm formation
COIBCLKI_01306 1.6e-52 coaB 4.1.1.36, 6.3.2.5 H Phosphopantothenate-cysteine ligase
COIBCLKI_01307 3.3e-92 coaBC 4.1.1.36, 6.3.2.5 H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
COIBCLKI_01308 7.1e-93 panT S ECF transporter, substrate-specific component
COIBCLKI_01309 2.9e-91 panT S Psort location CytoplasmicMembrane, score
COIBCLKI_01310 3.8e-128 KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
COIBCLKI_01311 1e-235 vicK 2.7.13.3 T Histidine kinase
COIBCLKI_01313 0.0 parE 5.99.1.3 L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
COIBCLKI_01314 4.6e-126 ybhF_2 V abc transporter atp-binding protein
COIBCLKI_01315 3.8e-180 ybhR V ABC transporter
COIBCLKI_01316 5.1e-105 K Bacterial regulatory proteins, tetR family
COIBCLKI_01317 2.9e-30 KT response to antibiotic
COIBCLKI_01318 2.9e-215 hemN H Involved in the biosynthesis of porphyrin-containing compound
COIBCLKI_01319 2.6e-60 trkH P Cation transport protein
COIBCLKI_01320 1.2e-247 trkA P Potassium transporter peripheral membrane component
COIBCLKI_01321 1.2e-126 mta K Transcriptional
COIBCLKI_01322 4.4e-31 S Protein of unknown function (DUF3021)
COIBCLKI_01323 9e-75 K COG3279 Response regulator of the LytR AlgR family
COIBCLKI_01324 2e-122 cylB V ABC-2 type transporter
COIBCLKI_01327 8.7e-159 XK27_09825 V 'abc transporter, ATP-binding protein
COIBCLKI_01328 5.3e-133 yvfS V ABC-2 type transporter
COIBCLKI_01329 6.1e-188 purM 6.3.3.1, 6.3.4.13 F Phosphoribosylformylglycinamidine cyclo-ligase
COIBCLKI_01330 9.9e-277 purF 2.4.2.14 F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
COIBCLKI_01331 6.1e-39 nagB 3.1.1.31, 3.5.99.6 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
COIBCLKI_01332 5.3e-197 yceA S Belongs to the UPF0176 family
COIBCLKI_01333 1.6e-28 XK27_00085 K Transcriptional
COIBCLKI_01334 1.6e-21
COIBCLKI_01337 2.3e-165 yocS S Transporter
COIBCLKI_01338 7.5e-82 cdd 2.4.2.4, 3.5.4.5 F cytidine deaminase activity
COIBCLKI_01339 4.7e-64 yvfS V Transporter
COIBCLKI_01340 3.2e-07 N PFAM Uncharacterised protein family UPF0150
COIBCLKI_01341 1.1e-153 EG Permeases of the drug metabolite transporter (DMT) superfamily
COIBCLKI_01343 3.3e-59 ycaO O OsmC-like protein
COIBCLKI_01344 1.4e-291 I Acyltransferase
COIBCLKI_01345 8.7e-29 XK27_09805 S MORN repeat protein
COIBCLKI_01346 1.9e-28 ptpA 3.1.3.48 T Belongs to the low molecular weight phosphotyrosine protein phosphatase family
COIBCLKI_01347 3.6e-148 I Alpha/beta hydrolase family
COIBCLKI_01348 1.5e-155 folD 1.5.1.5, 3.5.4.9 F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
COIBCLKI_01349 1e-156 rrmA 2.1.1.187 Q cog cog0500
COIBCLKI_01350 6.7e-104 1.6.5.2 S NADPH-quinone reductase (modulator of drug activity B)
COIBCLKI_01351 2.6e-106 K Transcriptional regulator
COIBCLKI_01352 2.2e-35 lytC 3.5.1.28 M N-acetylmuramoyl-L-alanine amidase
COIBCLKI_01355 2.9e-31 yozG K Transcriptional regulator
COIBCLKI_01357 4.3e-121 ansA 3.5.1.1 EJ COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D

eggNOG-mapper v2 (Database: eggNOG v5.0, Jul. 2018 release)