# emapper version: emapper-2.0.1b-2-g816e190 emapper DB: 2.0 # command: ./emapper.py -i Streptococcus_thermophilus/1.contigAnn/FFN/A00000037.ffn --translate --temp_dir Streptococcus_thermophilus/4.eggNOG_mapper --output_dir Streptococcus_thermophilus/4.eggNOG_mapper --output A00000037 --cpu 36 --keep_mapping_files -m diamond # time: Wed Jul 13 03:49:43 2022 #query_name seed_eggNOG_ortholog seed_ortholog_evalue seed_ortholog_score best_tax_level Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction taxonomic scope eggNOG OGs best eggNOG OG COG Functional cat. eggNOG free text desc. MIPOCGNA_00001 435842.HMPREF0848_00522 8.3e-10 68.9 Bacilli ko:K14194 ko05150,map05150 ko00000,ko00001 Bacteria 1TV1Y@1239,4HBHJ@91061,COG2373@1,COG2373@2 NA|NA|NA Q the current gene model (or a revised gene model) may contain a frame shift MIPOCGNA_00003 888833.HMPREF9421_1411 9.4e-14 82.8 Bacilli ko:K14194 ko05150,map05150 ko00000,ko00001 Bacteria 1TV1Y@1239,4HBHJ@91061,COG2373@1,COG2373@2,COG2931@1,COG2931@2 NA|NA|NA Q the current gene model (or a revised gene model) may contain a frame shift MIPOCGNA_00004 888833.HMPREF9421_1411 9e-11 72.4 Bacilli ko:K14194 ko05150,map05150 ko00000,ko00001 Bacteria 1TV1Y@1239,4HBHJ@91061,COG2373@1,COG2373@2,COG2931@1,COG2931@2 NA|NA|NA Q the current gene model (or a revised gene model) may contain a frame shift MIPOCGNA_00005 246201.SM12261_0398 3.2e-17 94.0 Streptococcus mitis Bacteria 1U4JG@1239,2AHCZ@1,2TPZV@28037,317PX@2,4IEB9@91061 NA|NA|NA S Domain of unknown function (DUF4649) MIPOCGNA_00006 264199.stu1190 5.8e-175 620.2 Bacilli XK27_08835 ko:K01989,ko:K05832 M00247 ko00000,ko00002,ko02000 Bacteria 1TPB0@1239,4HE7G@91061,COG2984@1,COG2984@2 NA|NA|NA S ABC transporter substrate binding protein MIPOCGNA_00007 264199.stu1189 1.3e-143 515.8 Bacilli XK27_08840 ko:K01989,ko:K05832 M00247 ko00000,ko00002,ko02000 Bacteria 1TPDJ@1239,4HBMY@91061,COG4120@1,COG4120@2 NA|NA|NA S Belongs to the binding-protein-dependent transport system permease family MIPOCGNA_00008 264199.stu1188 8.4e-134 483.0 Bacilli XK27_08845 ko:K05833 M00247 ko00000,ko00002,ko02000 Bacteria 1TPAN@1239,4HCHC@91061,COG1101@1,COG1101@2 NA|NA|NA S abc transporter atp-binding protein MIPOCGNA_00009 264199.stu1187 4.3e-308 1063.1 Bacilli rnjB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360 ko:K12574 ko03018,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 1TQ9G@1239,4HAAP@91061,COG0595@1,COG0595@2 NA|NA|NA S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay MIPOCGNA_00010 264199.stu1186 1.1e-149 535.8 Bacilli estA ko:K03930 ko00000,ko01000 CE1 Bacteria 1TPA9@1239,4IPZQ@91061,COG0627@1,COG0627@2 NA|NA|NA S Putative esterase MIPOCGNA_00011 264199.stu1185 6.1e-126 456.8 Bacilli XK27_08875 Bacteria 1VW9X@1239,4HWF8@91061,COG5549@1,COG5549@2 NA|NA|NA O Zinc-dependent metalloprotease MIPOCGNA_00012 1214166.ALLG01000018_gene972 3.3e-14 84.7 Streptococcus suis XK27_08880 Bacteria 1U92D@1239,1WTJN@1307,29R1H@1,30C2M@2,4IJ2X@91061 NA|NA|NA MIPOCGNA_00013 435842.HMPREF0848_00535 1e-75 289.3 Bacilli fld ko:K03839 ko00000 Bacteria 1V7AG@1239,4HMJF@91061,COG0716@1,COG0716@2 NA|NA|NA C Flavodoxin MIPOCGNA_00014 264199.stu1182 9.8e-283 978.8 Bacilli clcA GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006821,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015672,GO:0015698,GO:0015706,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0031404,GO:0034220,GO:0042802,GO:0043167,GO:0043168,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071705,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 ko:K03281 ko00000 2.A.49 iAF1260.b0155,iB21_1397.B21_00153,iBWG_1329.BWG_0148,iE2348C_1286.E2348C_0162,iEC042_1314.EC042_0155,iEC55989_1330.EC55989_0149,iECBD_1354.ECBD_3463,iECDH10B_1368.ECDH10B_0135,iECDH1ME8569_1439.ECDH1ME8569_0149,iECD_1391.ECD_00154,iECIAI1_1343.ECIAI1_0153,iECO103_1326.ECO103_0155,iECSE_1348.ECSE_0156,iECUMN_1333.ECUMN_0152,iECW_1372.ECW_m0152,iEKO11_1354.EKO11_3761,iETEC_1333.ETEC_0151,iEcDH1_1363.EcDH1_3447,iEcE24377_1341.EcE24377A_0160,iEcolC_1368.EcolC_3504,iJO1366.b0155,iSSON_1240.SSON_0167,iUMNK88_1353.UMNK88_159,iWFL_1372.ECW_m0152,iY75_1357.Y75_RS00790,iZ_1308.Z0166 Bacteria 1TPX0@1239,4HD2H@91061,COG0038@1,COG0038@2 NA|NA|NA P Chloride transporter, ClC family MIPOCGNA_00015 264199.stu1181 8.7e-41 172.6 Bacteria pheA GO:0003674,GO:0003824,GO:0004106,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 1.3.1.12,2.3.1.79,4.2.1.51,5.4.99.5 ko:K00661,ko:K04092,ko:K04093,ko:K04516,ko:K14170,ko:K14187 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715,R01728 RC00125,RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 iECNA114_1301.ECNA114_2667 Bacteria COG1605@1,COG1605@2 NA|NA|NA E Chorismate mutase MIPOCGNA_00016 322159.STER_1145 2.1e-219 768.1 Bacilli XK27_05110 Bacteria 1TPX0@1239,4HBN3@91061,COG0038@1,COG0038@2 NA|NA|NA P chloride MIPOCGNA_00017 264199.stu1179 8.5e-57 226.1 Bacilli rplS GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02884 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V6FT@1239,4HIK3@91061,COG0335@1,COG0335@2 NA|NA|NA J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site MIPOCGNA_00019 1046629.Ssal_01245 7.2e-20 102.4 Bacilli WQ51_02665 Bacteria 1VPEZ@1239,2C91M@1,33E1E@2,4HRR2@91061 NA|NA|NA S Protein of unknown function (DUF3042) MIPOCGNA_00020 264199.stu1177 3e-162 577.8 Bacilli miaA GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 Bacteria 1TPSC@1239,4HAVW@91061,COG0324@1,COG0324@2 NA|NA|NA J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) MIPOCGNA_00021 322159.STER_1139 2.7e-88 331.3 Bacilli ytsP 1.8.4.14 ko:K08968 ko00270,map00270 R02025 RC00639 ko00000,ko00001,ko01000 Bacteria 1V6GQ@1239,4HH7X@91061,COG1956@1,COG1956@2 NA|NA|NA T GAF domain-containing protein MIPOCGNA_00022 322159.STER_1138 7.1e-295 1019.2 Bacilli dnaX GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576 2.7.7.7 ko:K02341,ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 1TPS9@1239,4HAUE@91061,COG2812@1,COG2812@2 NA|NA|NA L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity MIPOCGNA_00023 322159.STER_1136 4.2e-175 620.5 Bacilli birA GO:0000166,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004077,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009305,GO:0009374,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0017053,GO:0017076,GO:0017144,GO:0018130,GO:0018271,GO:0019538,GO:0019752,GO:0019842,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032991,GO:0033218,GO:0033293,GO:0034641,GO:0035639,GO:0036094,GO:0036211,GO:0042364,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043565,GO:0043603,GO:0043604,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1990837 6.3.4.15 ko:K03524,ko:K04096 ko00780,ko01100,map00780,map01100 R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 Bacteria 1TQCU@1239,4HB60@91061,COG0340@1,COG0340@2,COG1654@1,COG1654@2 NA|NA|NA HK Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor MIPOCGNA_00024 322159.STER_1135 2.1e-203 714.9 Bacilli metK GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPCV@1239,4HB33@91061,COG0192@1,COG0192@2 NA|NA|NA H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme MIPOCGNA_00025 322159.STER_1134 1.3e-36 160.2 Firmicutes 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 Bacteria 1UYUX@1239,COG0451@1,COG0451@2 NA|NA|NA GM Psort location CytoplasmicMembrane, score MIPOCGNA_00026 322159.STER_1125 6e-196 689.9 Bacilli galE 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQ7N@1239,4H9U5@91061,COG1087@1,COG1087@2 NA|NA|NA M Belongs to the NAD(P)-dependent epimerase dehydratase family MIPOCGNA_00028 322159.STER_1123 9.4e-231 805.8 Bacilli murA 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 R00660 RC00350 ko00000,ko00001,ko01000,ko01011 Bacteria 1TPAU@1239,4H9KI@91061,COG0766@1,COG0766@2 NA|NA|NA M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine MIPOCGNA_00029 264199.stu1166 1.2e-25 121.7 Bacilli epuA Bacteria 1VMAH@1239,2EK0E@1,33DQZ@2,4HRG1@91061 NA|NA|NA S DNA-directed RNA polymerase subunit beta MIPOCGNA_00030 435842.HMPREF0848_00555 1.4e-145 522.3 Bacilli endA ko:K15051 ko00000 Bacteria 1V4X2@1239,4HIF5@91061,COG2169@1,COG2169@2 NA|NA|NA F DNA RNA non-specific endonuclease MIPOCGNA_00031 264199.stu1164 1.2e-109 402.5 Bacilli tcyB_2 ko:K02029,ko:K02030,ko:K10040,ko:K17073,ko:K17074 ko02010,map02010 M00228,M00236,M00589 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.20 Bacteria 1V14N@1239,4HJ9W@91061,COG0765@1,COG0765@2 NA|NA|NA P ABC transporter (permease) MIPOCGNA_00032 322159.STER_1119 1.8e-114 418.7 Bacilli gltJ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02029,ko:K10003,ko:K10040 ko02010,ko02020,map02010,map02020 M00228,M00230,M00236 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.19,3.A.1.3.4 iJN746.PP_1070 Bacteria 1TQ5K@1239,4HE9C@91061,COG0765@1,COG0765@2 NA|NA|NA P ABC transporter (Permease MIPOCGNA_00033 322159.STER_1118 3.1e-150 537.7 Bacilli peb1A GO:0005575,GO:0005623,GO:0009986,GO:0044464 ko:K10039 ko02010,map02010 M00228 ko00000,ko00001,ko00002,ko02000 3.A.1.3 Bacteria 1TT11@1239,4HAHV@91061,COG0834@1,COG0834@2 NA|NA|NA ET ABC-type amino acid transport signal transduction systems, periplasmic component domain MIPOCGNA_00034 322159.STER_1117 2.1e-140 505.0 Bacilli glnQ 3.6.3.21 ko:K02028,ko:K10041 ko02010,map02010 M00228,M00236 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3 Bacteria 1TNYD@1239,4H9WY@91061,COG1126@1,COG1126@2 NA|NA|NA E abc transporter atp-binding protein MIPOCGNA_00035 322159.STER_1116 9.9e-129 466.1 Bacilli Bacteria 1TPQG@1239,4HA8Q@91061,COG0745@1,COG0745@2 NA|NA|NA KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain MIPOCGNA_00036 322159.STER_1115 5.8e-247 859.8 Bacilli vicK 2.7.13.3 ko:K07652 ko02020,map02020 M00459 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1TQ1H@1239,4HA52@91061,COG5002@1,COG5002@2 NA|NA|NA T Histidine kinase MIPOCGNA_00037 322159.STER_1114 3.9e-153 547.4 Bacilli vicX 3.1.26.11 ko:K00784 ko03013,map03013 ko00000,ko00001,ko01000,ko03016 Bacteria 1TQ8E@1239,4HAKD@91061,COG1235@1,COG1235@2 NA|NA|NA S Metal-dependent hydrolases of the beta-lactamase superfamily I MIPOCGNA_00038 322159.STER_1113 4.2e-34 150.2 Bacteria ko:K09790 ko00000 Bacteria COG2832@1,COG2832@2 NA|NA|NA F Protein of unknown function (DUF454) MIPOCGNA_00039 264199.stu1155 3.4e-230 803.9 Bacilli murM 2.3.2.10,2.3.2.16 ko:K05363,ko:K11693,ko:K12554 ko00550,ko01100,map00550,map01100 R08776,R08779,R08780 RC00055,RC00064,RC00096 ko00000,ko00001,ko01000,ko01011 Bacteria 1TRZU@1239,4HC1Z@91061,COG2348@1,COG2348@2 NA|NA|NA V protein involved in methicillin resistance MIPOCGNA_00040 264199.stu1154 9.2e-147 526.2 Bacilli yidA GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050308 Bacteria 1TR16@1239,4HCZ6@91061,COG0561@1,COG0561@2 NA|NA|NA S hydrolases of the HAD superfamily MIPOCGNA_00041 322159.STER_1109 2.4e-44 184.5 Bacteria XK27_00115 2.3.1.128 ko:K03789 ko00000,ko01000,ko03009 Bacteria COG0454@1,COG0456@2 NA|NA|NA K acetyltransferase MIPOCGNA_00042 264199.stu1151 3.4e-67 260.8 Bacteria ywiB Bacteria COG4506@1,COG4506@2 NA|NA|NA S Domain of unknown function (DUF1934) MIPOCGNA_00043 264199.stu1150 0.0 1627.1 Bacilli pacL 3.6.3.8 ko:K01537 ko00000,ko01000 3.A.3.2 Bacteria 1TPF5@1239,4H9S5@91061,COG0474@1,COG0474@2 NA|NA|NA P cation transport ATPase MIPOCGNA_00044 322159.STER_1106 3.3e-135 487.6 Bacilli nfrA 1.5.1.38,1.5.1.39 ko:K19285,ko:K19286 ko00740,ko01100,map00740,map01100 R05705,R05706 RC00126 ko00000,ko00001,ko01000 Bacteria 1UB8S@1239,4HEGP@91061,COG0778@1,COG0778@2 NA|NA|NA C nitroreductase MIPOCGNA_00045 264199.stu1147 1.3e-181 642.1 Bacilli yjjH Bacteria 1V9B5@1239,4HJX0@91061,COG1409@1,COG1409@2 NA|NA|NA S Calcineurin-like phosphoesterase MIPOCGNA_00046 264199.stu1148 7.9e-202 709.5 Bacilli queG GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 ko:K18979 ko00000,ko01000,ko03016 Bacteria 1TP6Q@1239,4HAEW@91061,COG1600@1,COG1600@2 NA|NA|NA C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) MIPOCGNA_00047 264199.stu1146 5.3e-181 640.2 Bacilli prfB GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02836 ko00000,ko03012 Bacteria 1TPSB@1239,4H9N2@91061,COG1186@1,COG1186@2 NA|NA|NA J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA MIPOCGNA_00048 264199.stu1145 5.5e-124 450.3 Bacilli ftsE GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0019897,GO:0019898,GO:0030554,GO:0031234,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363 ko:K09811,ko:K09812 ko02010,map02010 M00256 ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 Bacteria 1TP58@1239,4H9Z2@91061,COG2884@1,COG2884@2 NA|NA|NA D cell division ATP-binding protein FtsE MIPOCGNA_00049 322159.STER_1100 5.2e-162 577.0 Bacilli ftsX GO:0000910,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0007154,GO:0007165,GO:0007166,GO:0008150,GO:0008356,GO:0009966,GO:0009987,GO:0010033,GO:0010646,GO:0016020,GO:0016021,GO:0016043,GO:0019221,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0023052,GO:0030312,GO:0031224,GO:0031226,GO:0032506,GO:0034097,GO:0040007,GO:0042173,GO:0042221,GO:0043937,GO:0043938,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051301,GO:0051716,GO:0065007,GO:0070098,GO:0070297,GO:0070887,GO:0071310,GO:0071345,GO:0071840,GO:0071944,GO:0090529,GO:1902531 ko:K09811,ko:K09812 ko02010,map02010 M00256 ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 Bacteria 1TPND@1239,4HA5A@91061,COG2177@1,COG2177@2 NA|NA|NA D Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation MIPOCGNA_00050 264199.stu1143 3.5e-93 347.4 Bacilli mutX 3.6.1.55 ko:K03574 ko00000,ko01000,ko03400 Bacteria 1V66I@1239,4HHRE@91061,COG1051@1,COG1051@2 NA|NA|NA F NTP pyrophosphohydrolases including oxidative damage repair enzymes MIPOCGNA_00051 264199.stu1142 8.1e-176 623.2 Bacilli yubA Bacteria 1TQ84@1239,4H9SR@91061,COG0628@1,COG0628@2 NA|NA|NA S permease MIPOCGNA_00052 264199.stu1141 5.4e-223 780.0 Bacilli Bacteria 1TT97@1239,4HAIA@91061,COG0457@1,COG0457@2 NA|NA|NA G COG0457 FOG TPR repeat MIPOCGNA_00053 322159.STER_1096 6e-97 360.1 Bacilli lepB 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 ko00000,ko00001,ko01000,ko01002 Bacteria 1V2BJ@1239,4HGCB@91061,COG0681@1,COG0681@2 NA|NA|NA U Belongs to the peptidase S26 family MIPOCGNA_00054 264199.stu1139 2.4e-43 181.4 Bacilli pepT GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0034641,GO:0034701,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045148,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.11.4 ko:K01258 ko00000,ko01000,ko01002 Bacteria 1TP3A@1239,4HAZE@91061,COG2195@1,COG2195@2 NA|NA|NA E Cleaves the N-terminal amino acid of tripeptides MIPOCGNA_00055 264199.stu1139 1.8e-139 501.9 Bacilli pepT GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0034641,GO:0034701,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045148,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.11.4 ko:K01258 ko00000,ko01000,ko01002 Bacteria 1TP3A@1239,4HAZE@91061,COG2195@1,COG2195@2 NA|NA|NA E Cleaves the N-terminal amino acid of tripeptides MIPOCGNA_00056 264199.stu1138 1.2e-88 332.4 Bacilli ebsA Bacteria 1VQ5S@1239,2FI04@1,349T2@2,4HYC5@91061 NA|NA|NA S Family of unknown function (DUF5322) MIPOCGNA_00057 264199.stu1136 2.8e-18 99.0 Bacilli Bacteria 1VD79@1239,4HT02@91061,COG1388@1,COG1388@2 NA|NA|NA M LysM domain MIPOCGNA_00058 322159.STER_1090 2.5e-121 441.4 Bacilli cmk GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015939,GO:0015940,GO:0015949,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 1.17.7.4,2.5.1.19,2.7.1.26,2.7.4.25,2.7.7.2,6.3.2.1 ko:K00800,ko:K00945,ko:K02945,ko:K03527,ko:K03977,ko:K11753,ko:K13799 ko00240,ko00400,ko00410,ko00740,ko00770,ko00900,ko01100,ko01110,ko01130,ko01230,ko03010,map00240,map00400,map00410,map00740,map00770,map00900,map01100,map01110,map01130,map01230,map03010 M00022,M00052,M00096,M00119,M00125,M00178 R00158,R00161,R00512,R00549,R01665,R02473,R03460,R05884,R08210 RC00002,RC00017,RC00096,RC00141,RC00350,RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03009,ko03011 iPC815.YPO1391,iSDY_1059.SDY_2348 Bacteria 1V3IA@1239,4HFZE@91061,COG0283@1,COG0283@2 NA|NA|NA F Belongs to the cytidylate kinase family. Type 1 subfamily MIPOCGNA_00059 264199.stu1134 5.9e-86 323.6 Bacilli infC GO:0000049,GO:0001731,GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016020,GO:0016043,GO:0019222,GO:0019538,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032268,GO:0032270,GO:0032790,GO:0032984,GO:0032988,GO:0032991,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043254,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045727,GO:0045948,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065003,GO:0065007,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901193,GO:1901195,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:1904688,GO:1904690,GO:1990856,GO:1990904,GO:2000112,GO:2000765,GO:2000767 ko:K02520 ko00000,ko03012,ko03029 Bacteria 1V1RC@1239,4HI4P@91061,COG0290@1,COG0290@2 NA|NA|NA J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins MIPOCGNA_00060 264199.stu1133 8.1e-28 129.0 Bacilli rpmI GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 ko:K02916 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1VF5W@1239,4HNIQ@91061,COG0291@1,COG0291@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL35 family MIPOCGNA_00061 1046629.Ssal_01190 1.5e-56 225.3 Bacilli rplT GO:0000027,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2000113,GO:2001141 ko:K02887 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V6DB@1239,4HH2W@91061,COG0292@1,COG0292@2 NA|NA|NA J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit MIPOCGNA_00062 322159.STER_1630 2.8e-137 494.6 Bacilli cppA Bacteria 1VMPM@1239,4HSVM@91061,COG0346@1,COG0346@2 NA|NA|NA E CppA N-terminal MIPOCGNA_00063 264199.stu1667 1.5e-183 648.7 Bacilli ampC Bacteria 1TNZX@1239,4IPJT@91061,COG1680@1,COG1680@2 NA|NA|NA V COG1680 Beta-lactamase class C and other penicillin binding proteins MIPOCGNA_00064 762051.LKI_10701 3.1e-31 140.6 Leuconostocaceae Bacteria 1VZDZ@1239,2DY5Q@1,34896@2,4AY9W@81850,4HZ9A@91061 NA|NA|NA MIPOCGNA_00065 322159.STER_1628 6.8e-116 423.3 Bacilli ybbL GO:0005575,GO:0005623,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0009987,GO:0016020,GO:0019725,GO:0030003,GO:0042592,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071944,GO:0098771 ko:K02065,ko:K02068 ko02010,map02010 M00210,M00211,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 1V3DQ@1239,4HHGU@91061,COG4619@1,COG4619@2 NA|NA|NA S abc transporter atp-binding protein MIPOCGNA_00066 264199.stu1665 2.3e-123 448.4 Bacilli ybbM GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0009987,GO:0015075,GO:0016020,GO:0016021,GO:0019725,GO:0022857,GO:0030003,GO:0031224,GO:0031226,GO:0034220,GO:0042592,GO:0044425,GO:0044459,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071944,GO:0098771 ko:K02069 M00211 ko00000,ko00002,ko02000 9.B.25.1 Bacteria 1UY1N@1239,4HDM4@91061,COG0390@1,COG0390@2 NA|NA|NA S transport system, permease component MIPOCGNA_00067 264199.stu1664 7.6e-118 429.9 Bacteria XK27_05540 Bacteria COG1434@1,COG1434@2 NA|NA|NA S Gram-negative-bacterium-type cell wall biogenesis MIPOCGNA_00068 203120.LEUM_A08 4.8e-58 230.3 Leuconostocaceae ko:K04763 ko00000,ko03036 Bacteria 1VEIE@1239,4AX2E@81850,4HK3N@91061,COG0582@1,COG0582@2 NA|NA|NA L Phage integrase family MIPOCGNA_00069 264199.stu1663 1.2e-32 145.2 Bacteria ko:K04763 ko00000,ko03036 Bacteria COG0582@1,COG0582@2 NA|NA|NA L DNA integration MIPOCGNA_00070 349519.LCK_p400004 1.5e-86 325.5 Leuconostocaceae Bacteria 1UI5C@1239,4AWZS@81850,4ISE9@91061,COG0497@1,COG0497@2 NA|NA|NA L Plasmid recombination enzyme MIPOCGNA_00072 322159.STER_1624 1e-84 319.3 Bacilli yjcF ko:K02348 ko00000 Bacteria 1VA2J@1239,4HKF5@91061,COG2153@1,COG2153@2 NA|NA|NA S COG0454 Histone acetyltransferase HPA2 and related acetyltransferases MIPOCGNA_00073 264199.stu1658 2.9e-38 164.1 Bacilli cah 4.2.1.1 ko:K01674 ko00910,map00910 R00132,R10092 RC02807 ko00000,ko00001,ko01000 Bacteria 1V16J@1239,4HA62@91061,COG3338@1,COG3338@2 NA|NA|NA P carbonic anhydrase MIPOCGNA_00074 322159.STER_1623 7.2e-43 179.5 Bacilli cah 4.2.1.1 ko:K01674 ko00910,map00910 R00132,R10092 RC02807 ko00000,ko00001,ko01000 Bacteria 1V16J@1239,4HA62@91061,COG3338@1,COG3338@2 NA|NA|NA P carbonic anhydrase MIPOCGNA_00075 264199.stu1657 0.0 1551.2 Bacilli pflB 2.3.1.54 ko:K00656 ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 R00212,R06987 RC00004,RC01181,RC02742,RC02833 ko00000,ko00001,ko01000 Bacteria 1TPTF@1239,4H9RD@91061,COG1882@1,COG1882@2 NA|NA|NA C formate acetyltransferase' MIPOCGNA_00076 322159.STER_1621 8.8e-201 706.1 Bacilli dinB GO:0000731,GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016604,GO:0016607,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019985,GO:0031668,GO:0031974,GO:0031981,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0035770,GO:0036464,GO:0042276,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0070013,GO:0071496,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1990904 2.7.7.7 ko:K02346 ko00000,ko01000,ko03400 Bacteria 1TP42@1239,4HADJ@91061,COG0389@1,COG0389@2 NA|NA|NA L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII MIPOCGNA_00078 264199.stu1654 4.8e-151 540.4 Bacilli yxeM ko:K02030 M00236 ko00000,ko00002,ko02000 3.A.1.3 Bacteria 1V7WQ@1239,4HK1Z@91061,COG0834@1,COG0834@2 NA|NA|NA ET ABC-type amino acid transport signal transduction systems, periplasmic component domain MIPOCGNA_00079 264199.stu1653 2.3e-162 578.2 Bacilli yxeN ko:K02029,ko:K16959,ko:K16962 ko02010,map02010 M00236,M00585,M00586 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.13 Bacteria 1UZ2C@1239,4HF77@91061,COG0765@1,COG0765@2 NA|NA|NA P ABC transporter (Permease MIPOCGNA_00080 322159.STER_1617 1.3e-131 475.7 Bacilli tcyN 3.6.3.21 ko:K02028,ko:K10010,ko:K16960,ko:K16963 ko02010,map02010 M00234,M00236,M00585,M00586 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.10,3.A.1.3.13,3.A.1.3.14 Bacteria 1TNYD@1239,4H9WY@91061,COG1126@1,COG1126@2 NA|NA|NA E abc transporter atp-binding protein MIPOCGNA_00081 40041.SZO_03890 1.1e-09 68.9 Streptococcus dysgalactiae group Bacteria 1M9T3@119603,1TXCH@1239,29I01@1,304X3@2,4I6AC@91061 NA|NA|NA S Protein of unknown function (DUF4059) MIPOCGNA_00082 264199.stu1650 5.5e-172 610.1 Bacilli trxB 1.8.1.9 ko:K00384 ko00450,map00450 R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 Bacteria 1TNZS@1239,4HA4N@91061,COG0492@1,COG0492@2 NA|NA|NA C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family MIPOCGNA_00083 264199.stu1649 4.3e-92 344.0 Bacilli rsmD 2.1.1.171 ko:K08316 R07234 RC00003 ko00000,ko01000,ko03009 Bacteria 1V3JF@1239,4HGXT@91061,COG0742@1,COG0742@2 NA|NA|NA L Methyltransferase MIPOCGNA_00084 264199.stu1648 1.7e-87 328.6 Bacilli coaD 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 1V3MR@1239,4HH47@91061,COG0669@1,COG0669@2 NA|NA|NA H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate MIPOCGNA_00085 264199.stu1647 7.8e-194 682.9 Bacilli ylbL ko:K07177 ko02024,map02024 ko00000,ko00001,ko01002 Bacteria 1TRUF@1239,4HBAY@91061,COG3480@1,COG3480@2 NA|NA|NA T Belongs to the peptidase S16 family MIPOCGNA_00086 264199.stu1646 1.3e-179 635.6 Bacilli yhcC GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464,GO:0048037,GO:0051536,GO:0051539,GO:0051540 ko:K07139 ko00000 Bacteria 1TQ57@1239,4H9N8@91061,COG1242@1,COG1242@2 NA|NA|NA S radical SAM protein MIPOCGNA_00087 264199.stu1645 2e-97 361.7 Bacilli ytqB 2.1.1.176 ko:K03500 ko00000,ko01000,ko03009 Bacteria 1UHQD@1239,4HIMC@91061,COG0144@1,COG0144@2 NA|NA|NA J (SAM)-dependent MIPOCGNA_00089 264199.stu1643 0.0 1248.8 Bacilli yjcE GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006814,GO:0006873,GO:0006885,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015079,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015386,GO:0015491,GO:0015672,GO:0016020,GO:0019725,GO:0022804,GO:0022821,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0035725,GO:0042592,GO:0044464,GO:0046873,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098657,GO:0098659,GO:0098660,GO:0098662,GO:0098719,GO:0098739,GO:0098771,GO:0099516,GO:0099587,GO:1902600 ko:K03316 ko00000 2.A.36 Bacteria 1TR4G@1239,4HBJR@91061,COG0025@1,COG0025@2 NA|NA|NA P NhaP-type Na H and K H antiporters MIPOCGNA_00090 264199.stu1642 2.1e-143 515.0 Bacilli modF GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 3.6.3.21,3.6.3.34 ko:K02013,ko:K02028,ko:K05776 ko02010,map02010 M00189,M00236,M00240 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14,3.A.1.3 Bacteria 1TRR4@1239,4HB4U@91061,COG1119@1,COG1119@2 NA|NA|NA P abc transporter atp-binding protein MIPOCGNA_00091 264199.stu1641 7.6e-239 832.8 Bacilli hlyX ko:K03699 ko00000,ko02042 Bacteria 1TPN0@1239,4H9SB@91061,COG1253@1,COG1253@2 NA|NA|NA S COG1253 Hemolysins and related proteins containing CBS domains MIPOCGNA_00092 264199.stu1640 2e-157 561.6 Bacilli pflA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0018307,GO:0019538,GO:0033554,GO:0036211,GO:0043170,GO:0043364,GO:0043365,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0055114,GO:0070283,GO:0071704,GO:1901564 1.97.1.4 ko:K04069 R04710 ko00000,ko01000 iECOK1_1307.ECOK1_0925,iEcE24377_1341.EcE24377A_0980,iEcSMS35_1347.EcSMS35_2219,iYL1228.KPN_00930 Bacteria 1TPK2@1239,4HACV@91061,COG1180@1,COG1180@2 NA|NA|NA C Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine MIPOCGNA_00094 264199.stu1637 6.9e-75 286.6 Bacilli XK27_03180 ko:K03499,ko:K06149 ko00000,ko02000 2.A.38.1,2.A.38.4 Bacteria 1V3NY@1239,4HIP3@91061,COG0589@1,COG0589@2 NA|NA|NA T universal stress protein MIPOCGNA_00095 322159.STER_1600 3.7e-240 837.0 Bacilli alaA GO:0003674,GO:0003824,GO:0004021,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006090,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016769,GO:0019272,GO:0019752,GO:0019842,GO:0030170,GO:0030632,GO:0032787,GO:0033554,GO:0036094,GO:0040007,GO:0042221,GO:0042851,GO:0042852,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0046677,GO:0047635,GO:0048037,GO:0050662,GO:0050896,GO:0051716,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.2,2.6.1.66 ko:K00814,ko:K14260 ko00220,ko00250,ko00290,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00220,map00250,map00290,map00710,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00171 R00258,R01215 RC00006,RC00008,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 iNJ661.Rv0337c Bacteria 1TP0J@1239,4HD83@91061,COG0436@1,COG0436@2 NA|NA|NA E Aminotransferase MIPOCGNA_00096 264199.stu1635 2.8e-140 504.6 Bacilli codY GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0044424,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 ko:K03706 ko00000,ko03000 Bacteria 1TS7A@1239,4HA9U@91061,COG4465@1,COG4465@2 NA|NA|NA K DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor MIPOCGNA_00097 322159.STER_1598 7.5e-100 369.8 Bacilli pncA ko:K16788 ko00000,ko02000 2.A.88.5 iSB619.SA_RS09955 Bacteria 1V1CY@1239,4HFRS@91061,COG1335@1,COG1335@2 NA|NA|NA Q isochorismatase MIPOCGNA_00098 264199.stu1633 4.8e-154 550.4 Bacilli hlpA ko:K02073 ko02010,map02010 M00238 ko00000,ko00001,ko00002,ko02000 3.A.1.24 Bacteria 1TQAS@1239,4HCTA@91061,COG1464@1,COG1464@2 NA|NA|NA M Belongs to the NlpA lipoprotein family MIPOCGNA_00099 264199.stu1632 4.7e-96 357.1 Bacilli msrA 1.8.4.11,1.8.4.12 ko:K07304,ko:K12267 ko00000,ko01000 Bacteria 1TQ3E@1239,4HAIV@91061,COG0225@1,COG0225@2 NA|NA|NA O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine MIPOCGNA_00100 904306.HMPREF9192_0728 7.3e-258 896.0 Bacilli ascB 3.2.1.86 ko:K01223 ko00010,ko00500,map00010,map00500 R00839,R05133,R05134 RC00049,RC00171,RC00714 ko00000,ko00001,ko01000 GT1 Bacteria 1TP19@1239,4HA1W@91061,COG2723@1,COG2723@2 NA|NA|NA G Belongs to the glycosyl hydrolase 1 family MIPOCGNA_00101 1046629.Ssal_00409 1.4e-47 195.3 Bacilli gatC 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 iAF987.Gmet_0076 Bacteria 1VEK3@1239,4HNNA@91061,COG0721@1,COG0721@2 NA|NA|NA J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) MIPOCGNA_00102 264199.stu1626 7.7e-269 932.6 Bacilli gatA 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 Bacteria 1TP0C@1239,4HBAZ@91061,COG0154@1,COG0154@2 NA|NA|NA J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) MIPOCGNA_00103 322159.STER_1590 5.1e-273 946.4 Bacilli gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.12,6.3.5.6,6.3.5.7 ko:K01876,ko:K02434 ko00970,ko01100,map00970,map01100 M00359,M00360 R03905,R04212,R05577 RC00010,RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Bacteria 1TPG3@1239,4HAFB@91061,COG0064@1,COG0064@2 NA|NA|NA J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) MIPOCGNA_00104 264199.stu1624 1.6e-64 251.9 Firmicutes Bacteria 1VBNR@1239,2B9ZC@1,323D0@2 NA|NA|NA MIPOCGNA_00105 322159.STER_1587 4.5e-80 303.9 Bacilli yicL Bacteria 1TR6G@1239,4HAMD@91061,COG0697@1,COG0697@2 NA|NA|NA EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily MIPOCGNA_00106 322159.STER_1587 2.1e-62 245.0 Bacilli yicL Bacteria 1TR6G@1239,4HAMD@91061,COG0697@1,COG0697@2 NA|NA|NA EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily MIPOCGNA_00107 264199.stu1622 1.8e-98 365.2 Bacilli yqeG ko:K07015 ko00000 Bacteria 1V6KM@1239,4HGAV@91061,COG2179@1,COG2179@2 NA|NA|NA S hydrolase of the HAD superfamily MIPOCGNA_00108 322159.STER_1585 7.1e-214 749.6 Bacilli yqeH GO:0003674,GO:0003824,GO:0003924,GO:0006275,GO:0008150,GO:0008156,GO:0009889,GO:0009890,GO:0009892,GO:0010556,GO:0010558,GO:0010605,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019219,GO:0019222,GO:0022613,GO:0030174,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0042254,GO:0044085,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0060255,GO:0065007,GO:0071840,GO:0080090,GO:0090329,GO:2000104,GO:2000112,GO:2000113 ko:K06948 ko00000,ko03009 Bacteria 1TPM2@1239,4HAAF@91061,COG1161@1,COG1161@2 NA|NA|NA S in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis MIPOCGNA_00109 264199.stu1620 3.5e-49 200.7 Bacilli yhbY GO:0000027,GO:0000028,GO:0000966,GO:0000967,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0034470,GO:0034471,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0042274,GO:0043021,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1990275 ko:K07574 ko00000,ko03009 Bacteria 1VEGM@1239,4HKC7@91061,COG1534@1,COG1534@2 NA|NA|NA J RNA-binding protein MIPOCGNA_00110 264199.stu1619 1.7e-116 425.2 Bacilli nadD GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18,3.6.1.55 ko:K00969,ko:K03574 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 Bacteria 1V3SK@1239,4HGXK@91061,COG1057@1,COG1057@2 NA|NA|NA H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) MIPOCGNA_00111 264199.stu1618 4e-107 394.0 Bacilli nadD 2.7.6.3,2.7.7.18 ko:K00950,ko:K00969,ko:K06950 ko00760,ko00790,ko01100,map00760,map00790,map01100 M00115,M00126,M00841 R00137,R03005,R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 1V6Y1@1239,4HHRY@91061,COG1713@1,COG1713@2 NA|NA|NA H HD superfamily hydrolase involved in NAD metabolism MIPOCGNA_00112 322159.STER_1581 6e-58 229.9 Bacilli rsfS GO:0003674,GO:0005488,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113 ko:K09710 ko00000,ko03009 Bacteria 1VA2Z@1239,4HKEJ@91061,COG0799@1,COG0799@2 NA|NA|NA J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation MIPOCGNA_00113 322159.STER_1580 1.3e-139 502.3 Bacilli yqeM Bacteria 1V24K@1239,4HDFY@91061,COG0500@1,COG2226@2 NA|NA|NA Q Methyltransferase domain protein MIPOCGNA_00114 322159.STER_1579 1.9e-200 704.9 Bacilli ylbM Bacteria 1TPP2@1239,4HAZJ@91061,COG1323@1,COG1323@2 NA|NA|NA S Belongs to the UPF0348 family MIPOCGNA_00115 264199.stu1614 0.0 1320.8 Bacilli clpL ko:K04086 ko00000,ko03110 Bacteria 1TRHP@1239,4HAHZ@91061,COG0542@1,COG0542@2 NA|NA|NA O ATP-dependent Clp protease ATP-binding subunit MIPOCGNA_00116 264199.stu1049 6.8e-170 603.6 Bacilli acoC 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1TR5N@1239,4HDFT@91061,COG0508@1,COG0508@2 NA|NA|NA C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex MIPOCGNA_00117 322159.STER_1033 0.0 1106.7 Bacilli lpdA 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1TP1W@1239,4H9Z5@91061,COG1249@1,COG1249@2 NA|NA|NA C Dehydrogenase MIPOCGNA_00118 904306.HMPREF9192_1715 9.9e-12 75.9 Bacteria 3.5.1.28 ko:K01448,ko:K02395,ko:K21471 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko02035,ko03036 Bacteria COG0860@1,COG0860@2,COG1705@1,COG1705@2,COG3757@1,COG3757@2,COG5263@1,COG5263@2 NA|NA|NA NU amidase activity MIPOCGNA_00119 1046629.Ssal_01134 2.7e-67 261.2 Bacilli 3.4.17.14,3.5.1.28 ko:K01448,ko:K02395,ko:K07260,ko:K07273 ko00550,ko01100,ko01502,ko01503,ko02020,map00550,map01100,map01502,map01503,map02020 M00651,M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504,ko02035,ko03036 Bacteria 1W25V@1239,4HGXW@91061,COG0860@1,COG0860@2,COG1705@1,COG1705@2,COG3757@1,COG3757@2 NA|NA|NA M GBS Bsp-like repeat MIPOCGNA_00120 322159.STER_1030 7e-173 613.2 Bacilli 3.5.1.28 ko:K01448,ko:K07273 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 Bacteria 1W25V@1239,4HGXW@91061,COG0860@1,COG0860@2 NA|NA|NA M GBS Bsp-like repeat MIPOCGNA_00121 1046629.Ssal_01131 2.9e-208 731.1 Bacilli pulA 3.2.1.1,3.2.1.41 ko:K01176,ko:K01200 ko00500,ko01100,ko01110,ko04973,map00500,map01100,map01110,map04973 R02108,R02111,R02112,R11262 ko00000,ko00001,ko01000 CBM48,GH13 Bacteria 1TP3M@1239,4HBP5@91061,COG1523@1,COG1523@2 NA|NA|NA G belongs to the glycosyl hydrolase 13 family MIPOCGNA_00122 1046629.Ssal_01131 1.7e-60 238.4 Bacilli pulA 3.2.1.1,3.2.1.41 ko:K01176,ko:K01200 ko00500,ko01100,ko01110,ko04973,map00500,map01100,map01110,map04973 R02108,R02111,R02112,R11262 ko00000,ko00001,ko01000 CBM48,GH13 Bacteria 1TP3M@1239,4HBP5@91061,COG1523@1,COG1523@2 NA|NA|NA G belongs to the glycosyl hydrolase 13 family MIPOCGNA_00123 264199.stu1031 3.7e-85 320.9 Bacilli pulA 3.2.1.1,3.2.1.41 ko:K01176,ko:K01200 ko00500,ko01100,ko01110,ko04973,map00500,map01100,map01110,map04973 R02108,R02111,R02112,R11262 ko00000,ko00001,ko01000 CBM48,GH13 Bacteria 1TP3M@1239,4HBP5@91061,COG1523@1,COG1523@2 NA|NA|NA G belongs to the glycosyl hydrolase 13 family MIPOCGNA_00124 1046629.Ssal_01131 3e-34 151.0 Bacilli pulA 3.2.1.1,3.2.1.41 ko:K01176,ko:K01200 ko00500,ko01100,ko01110,ko04973,map00500,map01100,map01110,map04973 R02108,R02111,R02112,R11262 ko00000,ko00001,ko01000 CBM48,GH13 Bacteria 1TP3M@1239,4HBP5@91061,COG1523@1,COG1523@2 NA|NA|NA G belongs to the glycosyl hydrolase 13 family MIPOCGNA_00125 322159.STER_1024 3.2e-153 547.7 Bacilli ycdO GO:0000041,GO:0006810,GO:0006811,GO:0006812,GO:0006826,GO:0008150,GO:0015684,GO:0030001,GO:0051179,GO:0051234,GO:0070838,GO:0072511 ko:K07224,ko:K07243 ko00000,ko02000 2.A.108.1,2.A.108.2,2.A.108.2.3 Bacteria 1TS89@1239,4HB0W@91061,COG2822@1,COG2822@2 NA|NA|NA P periplasmic lipoprotein involved in iron transport MIPOCGNA_00126 322159.STER_1023 5.6e-233 813.1 Bacilli ycdB ko:K16301 ko00000,ko01000,ko02000 2.A.108.2.3 Bacteria 1UY9Y@1239,4HACQ@91061,COG2837@1,COG2837@2 NA|NA|NA P peroxidase MIPOCGNA_00127 322159.STER_1022 7.2e-303 1045.8 Bacilli ywbL ko:K07243 ko00000,ko02000 2.A.108.1,2.A.108.2 Bacteria 1TQIA@1239,4HCJZ@91061,COG0672@1,COG0672@2 NA|NA|NA P COG0672 High-affinity Fe2 Pb2 permease MIPOCGNA_00128 322159.STER_1021 4.4e-121 440.7 Bacilli tatC GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 ko:K03118 ko03060,ko03070,map03060,map03070 M00336 ko00000,ko00001,ko00002,ko02044 2.A.64 Bacteria 1U7N7@1239,4HB1U@91061,COG0805@1,COG0805@2 NA|NA|NA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes MIPOCGNA_00129 264199.stu1020 4.6e-25 119.8 Bacteria tatA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K03116,ko:K03117 ko03060,ko03070,map03060,map03070 M00336 ko00000,ko00001,ko00002,ko02044 2.A.64 Bacteria COG1826@1,COG1826@2 NA|NA|NA U protein secretion MIPOCGNA_00130 1069533.Sinf_0020 2.3e-23 114.4 Firmicutes Bacteria 1TQ93@1239,COG3464@1,COG3464@2 NA|NA|NA L Transposase MIPOCGNA_00131 264199.stu1013 1.7e-300 1037.7 Bacilli malQ 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 R05196 RC00049 ko00000,ko00001,ko01000 GH77 Bacteria 1W5VQ@1239,4HCHB@91061,COG1640@1,COG1640@2 NA|NA|NA G 4-alpha-glucanotransferase MIPOCGNA_00132 322159.STER_1016 0.0 1494.6 Bacilli glgP 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 R02111 ko00000,ko00001,ko01000 GT35 Bacteria 1TQAJ@1239,4H9XI@91061,COG0058@1,COG0058@2 NA|NA|NA G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties MIPOCGNA_00133 888816.HMPREF9389_1786 3.7e-09 68.2 Streptococcus sanguinis Bacteria 1UA7P@1239,1WRVC@1305,2AQRJ@1,31FZC@2,4IKIV@91061 NA|NA|NA MIPOCGNA_00136 322159.STER_1014 1.5e-186 658.7 Bacilli lplA 6.3.1.20 ko:K03800 ko00785,ko01100,map00785,map01100 R07770,R07771,R11143 RC00043,RC00070,RC00090,RC00992,RC02896 ko00000,ko00001,ko01000 Bacteria 1TQ5U@1239,4H9P6@91061,COG0095@1,COG0095@2 NA|NA|NA H Lipoate-protein ligase MIPOCGNA_00138 322159.STER_1013 1e-193 682.6 Bacilli xerS GO:0000150,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009987,GO:0015074,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140097,GO:1901360 Bacteria 1URNQ@1239,4HEPI@91061,COG4974@1,COG4974@2 NA|NA|NA D Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division MIPOCGNA_00139 264199.stu1007 0.0 1681.0 Bacilli pepN GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.4.11.2 ko:K01256,ko:K08776 ko00480,ko01100,map00480,map01100 R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 Bacteria 1TR43@1239,4HA20@91061,COG0308@1,COG0308@2 NA|NA|NA E aminopeptidase MIPOCGNA_00140 322159.STER_1011 1.9e-113 415.2 Bacilli phoU ko:K02039 ko00000 Bacteria 1URN3@1239,4HEU9@91061,COG0704@1,COG0704@2 NA|NA|NA P Plays a role in the regulation of phosphate uptake MIPOCGNA_00141 322159.STER_1010 2.3e-139 501.5 Bacilli pstB 3.6.3.27 ko:K02036 ko02010,map02010 M00222 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 iLJ478.TM1261 Bacteria 1TP1M@1239,4HAB1@91061,COG1117@1,COG1117@2 NA|NA|NA P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system MIPOCGNA_00142 322159.STER_1009 1e-150 539.3 Bacilli pstB 3.6.3.27 ko:K02036 ko02010,map02010 M00222 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 iLJ478.TM1261 Bacteria 1TP1M@1239,4HAB1@91061,COG1117@1,COG1117@2 NA|NA|NA P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system MIPOCGNA_00143 322159.STER_1008 1.5e-155 555.4 Bacilli pstA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02038 ko02010,map02010 M00222 ko00000,ko00001,ko00002,ko02000 3.A.1.7 Bacteria 1TP74@1239,4HAKF@91061,COG0581@1,COG0581@2 NA|NA|NA P phosphate transport system permease MIPOCGNA_00144 264199.stu1002 2.5e-156 558.1 Bacilli pstC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02037 ko02010,map02010 M00222 ko00000,ko00001,ko00002,ko02000 3.A.1.7 Bacteria 1TSPP@1239,4HC9H@91061,COG0573@1,COG0573@2 NA|NA|NA P probably responsible for the translocation of the substrate across the membrane MIPOCGNA_00145 322159.STER_1006 4.8e-157 560.5 Bacilli pstS GO:0003674,GO:0005488,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015698,GO:0042301,GO:0043167,GO:0043168,GO:0051179,GO:0051234 ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 ko00000,ko00001,ko00002,ko02000 3.A.1.7 Bacteria 1TQ5X@1239,4HBEB@91061,COG0226@1,COG0226@2 NA|NA|NA P phosphate MIPOCGNA_00146 322159.STER_1005 3.9e-256 890.2 Bacilli rsmF GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176,2.1.1.178 ko:K03500,ko:K11392 ko00000,ko01000,ko03009 Bacteria 1TPGQ@1239,4HCHQ@91061,COG0144@1,COG0144@2,COG3270@1,COG3270@2 NA|NA|NA J NOL1 NOP2 sun family protein MIPOCGNA_00147 322159.STER_1004 4.2e-141 507.3 Bacilli suhB 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 Bacteria 1TR4E@1239,4HB92@91061,COG0483@1,COG0483@2 NA|NA|NA G Belongs to the inositol monophosphatase superfamily MIPOCGNA_00148 264199.stu0998 6.7e-44 183.0 Bacilli yktA ko:K16509 ko00000 Bacteria 1VEK8@1239,4HNKR@91061,COG4476@1,COG4476@2 NA|NA|NA S Belongs to the UPF0223 family MIPOCGNA_00149 264199.stu0997 3e-69 267.7 Bacilli spxA 1.20.4.1 ko:K00537,ko:K16509 ko00000,ko01000 Bacteria 1V3QC@1239,4HH0I@91061,COG1393@1,COG1393@2 NA|NA|NA K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress MIPOCGNA_00150 264199.stu0996 5.5e-172 610.1 Bacilli ribF 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS06310 Bacteria 1TPKS@1239,4H9KE@91061,COG0196@1,COG0196@2 NA|NA|NA H Belongs to the ribF family MIPOCGNA_00151 264199.stu0995 8.4e-151 539.7 Bacilli truB GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 ko:K03177,ko:K03483 ko00000,ko01000,ko03000,ko03016 iSB619.SA_RS06305 Bacteria 1TP9Y@1239,4HA9X@91061,COG0130@1,COG0130@2 NA|NA|NA J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs MIPOCGNA_00152 435842.HMPREF0848_00680 1.1e-34 152.1 Bacilli XK27_04775 ko:K09155 ko00000 Bacteria 1TRD5@1239,4HAAW@91061,COG2461@1,COG2461@2 NA|NA|NA S hemerythrin HHE cation binding domain MIPOCGNA_00153 1046629.Ssal_01094 1.3e-28 131.7 Bacilli XK27_04775 ko:K09155 ko00000 Bacteria 1TRD5@1239,4HAAW@91061,COG2461@1,COG2461@2 NA|NA|NA S hemerythrin HHE cation binding domain MIPOCGNA_00154 264199.stu0993 4e-32 143.7 Bacilli XK27_04775 ko:K09155 ko00000 Bacteria 1TRD5@1239,4HAAW@91061,COG2461@1,COG2461@2 NA|NA|NA S hemerythrin HHE cation binding domain MIPOCGNA_00155 264199.stu0993 5.8e-78 297.0 Bacilli XK27_04775 ko:K09155 ko00000 Bacteria 1TRD5@1239,4HAAW@91061,COG2461@1,COG2461@2 NA|NA|NA S hemerythrin HHE cation binding domain MIPOCGNA_00156 435842.HMPREF0848_00681 3.1e-31 140.6 Bacteria M1-755 ko:K09155 ko00000 Bacteria COG2461@1,COG2461@2 NA|NA|NA P Hemerythrin HHE cation binding domain protein MIPOCGNA_00157 264199.stu0991 1.1e-110 406.0 Bacilli hsdS2 2.1.1.72 ko:K03427 ko00000,ko01000,ko02048 Bacteria 1VQES@1239,4HE4K@91061,COG0732@1,COG0732@2 NA|NA|NA V Type I restriction modification DNA specificity domain MIPOCGNA_00158 264199.stu0990 3.8e-87 327.4 Bacilli tpx GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009405,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0015036,GO:0016209,GO:0016491,GO:0016667,GO:0016671,GO:0016684,GO:0019725,GO:0020012,GO:0030312,GO:0030682,GO:0032843,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0051920,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071944,GO:0075136,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 ko:K11065 ko00000,ko01000 Bacteria 1V474@1239,4HFMW@91061,COG2077@1,COG2077@2 NA|NA|NA O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides MIPOCGNA_00159 904306.HMPREF9192_1752 3.2e-133 481.1 Bacilli Bacteria 1TQTU@1239,4HEHK@91061,COG0561@1,COG0561@2 NA|NA|NA S haloacid dehalogenase-like hydrolase MIPOCGNA_00160 322159.STER_0995 2.3e-240 837.8 Bacilli metY 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 Bacteria 1VYCY@1239,4H9X5@91061,COG2873@1,COG2873@2 NA|NA|NA E o-acetylhomoserine MIPOCGNA_00161 322159.STER_0994 0.0 1385.5 Bacilli pcrA 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 1TPSU@1239,4HB12@91061,COG0210@1,COG0210@2 NA|NA|NA L ATP-dependent DNA helicase MIPOCGNA_00162 322159.STER_0993 7.6e-239 832.8 Bacilli agcS GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03310 ko00000 2.A.25 Bacteria 1TNZP@1239,4H9SZ@91061,COG1115@1,COG1115@2 NA|NA|NA E (Alanine) symporter MIPOCGNA_00163 322159.STER_0992 8.6e-246 855.9 Bacilli mnmE GO:0003674,GO:0005488,GO:0005515,GO:0042802 ko:K03650 R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 Bacteria 1TPJF@1239,4HA06@91061,COG0486@1,COG0486@2 NA|NA|NA S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 MIPOCGNA_00164 1046629.Ssal_01085 1.6e-23 114.8 Bacilli bglC Bacteria 1UZG6@1239,4HCQS@91061,COG2207@1,COG2207@2 NA|NA|NA K Transcriptional regulator MIPOCGNA_00165 264199.stu0981 1.4e-87 328.9 Bacteria yfiF3 Bacteria COG4977@1,COG4977@2 NA|NA|NA K sequence-specific DNA binding MIPOCGNA_00166 1046629.Ssal_01083 2.6e-23 114.4 Bacilli sasH 3.1.3.5,3.6.1.45 ko:K11751 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 Bacteria 1TPV2@1239,4H9VJ@91061,COG0737@1,COG0737@2 NA|NA|NA F Belongs to the 5'-nucleotidase family MIPOCGNA_00168 264199.stu0977 3.5e-21 106.7 Bacteria yecS GO:0000099,GO:0000101,GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006791,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015179,GO:0015184,GO:0015318,GO:0015711,GO:0015804,GO:0015807,GO:0015811,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0072348,GO:0072349,GO:0098656,GO:1901682,GO:1902475,GO:1903825,GO:1905039 ko:K10009 ko02010,map02010 M00234 ko00000,ko00001,ko00002,ko02000 3.A.1.3.10,3.A.1.3.14 iJN746.PP_0226 Bacteria COG0765@1,COG0765@2 NA|NA|NA P amino acid transport MIPOCGNA_00169 264199.stu0976 4.1e-66 257.3 Bacilli yecS GO:0000099,GO:0000101,GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006791,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015179,GO:0015184,GO:0015318,GO:0015711,GO:0015804,GO:0015807,GO:0015811,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0072348,GO:0072349,GO:0098656,GO:1901682,GO:1902475,GO:1903825,GO:1905039 ko:K10009 ko02010,map02010 M00234 ko00000,ko00001,ko00002,ko02000 3.A.1.3.10,3.A.1.3.14 iJN746.PP_0226 Bacteria 1TQ43@1239,4HCZV@91061,COG0765@1,COG0765@2 NA|NA|NA P ABC transporter (Permease MIPOCGNA_00170 264199.stu0975 1.1e-47 195.7 Bacilli artJ_1 ko:K02030,ko:K09996,ko:K09997 ko02010,map02010 M00229,M00236 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.3 Bacteria 1UHHG@1239,4H9NX@91061,COG0834@1,COG0834@2 NA|NA|NA ET Belongs to the bacterial solute-binding protein 3 family MIPOCGNA_00171 435842.HMPREF0848_00690 8.5e-79 299.7 Bacilli yckB ko:K02030,ko:K02424 ko02010,map02010 M00234,M00236 ko00000,ko00001,ko00002,ko02000,ko02035 3.A.1.3,3.A.1.3.10,3.A.1.3.14 Bacteria 1UHHG@1239,4H9NX@91061,COG0834@1,COG0834@2 NA|NA|NA ET Belongs to the bacterial solute-binding protein 3 family MIPOCGNA_00172 264199.stu0973 7.3e-85 320.5 Bacilli nylA 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 Bacteria 1TPGJ@1239,4HBE7@91061,COG0154@1,COG0154@2 NA|NA|NA J Belongs to the amidase family MIPOCGNA_00173 322159.STER_1260 4.8e-59 233.8 Bacilli XK27_01265 ko:K16923 M00582 ko00000,ko00002,ko02000 3.A.1.28 Bacteria 1VC0F@1239,4HMJM@91061,COG4720@1,COG4720@2 NA|NA|NA S ECF-type riboflavin transporter, S component MIPOCGNA_00174 322159.STER_1259 3.6e-293 1013.4 Bacilli yfmM ko:K06158 ko00000,ko03012 Bacteria 1TPAX@1239,4HC58@91061,COG0488@1,COG0488@2 NA|NA|NA S abc transporter atp-binding protein MIPOCGNA_00175 322159.STER_1258 8.3e-257 892.5 Bacilli noxE Bacteria 1TPWW@1239,4H9U7@91061,COG0446@1,COG0446@2 NA|NA|NA P NADH oxidase MIPOCGNA_00176 264199.stu1280 1.6e-180 638.6 Bacilli ldh 1.1.1.27 ko:K00016 ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922 R00703,R01000,R03104 RC00031,RC00044 ko00000,ko00001,ko01000,ko04147 Bacteria 1TPSY@1239,4HB0Z@91061,COG0039@1,COG0039@2 NA|NA|NA C Belongs to the LDH MDH superfamily. LDH family MIPOCGNA_00177 322159.STER_1256 0.0 1413.3 Bacilli gyrA GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 5.99.1.3 ko:K02469,ko:K02621 ko00000,ko01000,ko02048,ko03032,ko03036,ko03400 Bacteria 1TP2Z@1239,4HAHY@91061,COG0188@1,COG0188@2 NA|NA|NA L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner MIPOCGNA_00178 322159.STER_1255 1.6e-132 478.8 Bacilli srtA 3.4.22.70 ko:K07284 ko00000,ko01000,ko01002,ko01011 Bacteria 1V83Z@1239,4HIA0@91061,COG3764@1,COG3764@2 NA|NA|NA M Sortase (surface protein transpeptidase) MIPOCGNA_00179 264199.stu1276 9.8e-52 209.1 Firmicutes yaeR ko:K08234 ko00000 Bacteria 1V6XU@1239,COG0346@1,COG0346@2 NA|NA|NA E COG0346 LactoylglutaTHIone lyase and related lyases MIPOCGNA_00180 264199.stu1275 5.3e-165 587.0 Bacilli ypuA Bacteria 1TR2I@1239,4HBVZ@91061,COG4086@1,COG4086@2 NA|NA|NA S secreted protein MIPOCGNA_00181 264199.stu1274 8.8e-60 236.1 Bacteria Bacteria COG3547@1,COG3547@2 NA|NA|NA L Transposase (IS116 IS110 IS902 family) MIPOCGNA_00182 264199.stu1273 4.2e-71 273.9 Bacteria Bacteria COG3547@1,COG3547@2 NA|NA|NA L Transposase (IS116 IS110 IS902 family) MIPOCGNA_00184 264199.stu1271 8.6e-184 649.4 Bacilli nrdF 1.17.4.1 ko:K00526 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 Bacteria 1TQTH@1239,4H9WX@91061,COG0208@1,COG0208@2 NA|NA|NA F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides MIPOCGNA_00185 264199.stu1270 0.0 1441.4 Bacilli nrdE 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 iYO844.BSU17380 Bacteria 1TPFH@1239,4H9X0@91061,COG0209@1,COG0209@2 NA|NA|NA F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides MIPOCGNA_00186 264199.stu1269 8.5e-34 149.1 Bacilli nrdH GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009893,GO:0009987,GO:0016491,GO:0019222,GO:0019725,GO:0022900,GO:0042592,GO:0043085,GO:0044093,GO:0044237,GO:0045454,GO:0048518,GO:0050789,GO:0050790,GO:0050794,GO:0051341,GO:0051353,GO:0055114,GO:0065007,GO:0065008,GO:0065009 ko:K06191 ko00000 Bacteria 1VEFX@1239,4HNUX@91061,COG0695@1,COG0695@2 NA|NA|NA O Glutaredoxin MIPOCGNA_00187 264199.stu1268 0.0 1751.5 Bacilli acnA GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0043937,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0050789,GO:0050793,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0065007,GO:0071704,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS06730 Bacteria 1VTMM@1239,4HB5N@91061,COG1048@1,COG1048@2 NA|NA|NA C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate MIPOCGNA_00188 264199.stu1267 5.1e-212 743.4 Bacilli citZ 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1TPPS@1239,4H9YE@91061,COG0372@1,COG0372@2 NA|NA|NA C Belongs to the citrate synthase family MIPOCGNA_00189 264199.stu1266 8.2e-221 772.7 Bacilli icd GO:0003674,GO:0003824,GO:0003862,GO:0004448,GO:0004450,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006520,GO:0006551,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022900,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 e_coli_core.b1136,iAF1260.b1136,iECDH1ME8569_1439.ECDH1ME8569_1071,iEcDH1_1363.EcDH1_2511,iJN746.PP_4011,iJO1366.b1136,iJR904.b1136,iY75_1357.Y75_RS05930,iYL1228.KPN_01144 Bacteria 1UHPE@1239,4H9US@91061,COG0538@1,COG0538@2 NA|NA|NA C Isocitrate dehydrogenase MIPOCGNA_00190 264199.stu1265 7.9e-39 166.0 Bacilli ptsH GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0043610,GO:0044424,GO:0044464,GO:0050789,GO:0065007 ko:K11189 ko00000,ko02000 4.A.2.1 Bacteria 1VA0R@1239,4HKGA@91061,COG1925@1,COG1925@2 NA|NA|NA G phosphocarrier protein Hpr MIPOCGNA_00191 264199.stu1264 0.0 1087.4 Bacilli ptsI GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006810,GO:0008150,GO:0008643,GO:0008965,GO:0009401,GO:0016740,GO:0016772,GO:0016775,GO:0019197,GO:0032991,GO:0042802,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0051179,GO:0051234,GO:0071702 2.7.3.9 ko:K08483 ko02060,map02060 ko00000,ko00001,ko01000,ko02000 8.A.7 iB21_1397.B21_02277,iE2348C_1286.E2348C_2602,iEC042_1314.EC042_2625,iECBD_1354.ECBD_1265,iECB_1328.ECB_02316,iECD_1391.ECD_02316,iECH74115_1262.ECH74115_3647,iECIAI1_1343.ECIAI1_2474,iECIAI39_1322.ECIAI39_2562,iECO103_1326.ECO103_2935,iECO111_1330.ECO111_3146,iECO26_1355.ECO26_3469,iECP_1309.ECP_2440,iECSE_1348.ECSE_2707,iECSP_1301.ECSP_3364,iECUMN_1333.ECUMN_2738,iECW_1372.ECW_m2645,iECs_1301.ECs3288,iEKO11_1354.EKO11_1312,iEcE24377_1341.EcE24377A_2703,iEcHS_1320.EcHS_A2551,iEcSMS35_1347.EcSMS35_2571,iEcolC_1368.EcolC_1262,iLF82_1304.LF82_1770,iNRG857_1313.NRG857_12115,iSBO_1134.SBO_2440,iSDY_1059.SDY_2613,iSFV_1184.SFV_2468,iSF_1195.SF2471,iSFxv_1172.SFxv_2720,iSSON_1240.SSON_2505,iS_1188.S2617,iUMNK88_1353.UMNK88_3018,iWFL_1372.ECW_m2645,iZ_1308.Z3682 Bacteria 1TPK8@1239,4H9VD@91061,COG1080@1,COG1080@2 NA|NA|NA G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) MIPOCGNA_00192 264199.stu1263 8.6e-265 919.1 Bacilli gapN GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0043891,GO:0047100,GO:0055114 1.2.1.9 ko:K00131 ko00010,ko00030,ko01100,ko01120,ko01200,map00010,map00030,map01100,map01120,map01200 M00308,M00633 R01058 RC00242 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP4S@1239,4H9MF@91061,COG1012@1,COG1012@2 NA|NA|NA C Belongs to the aldehyde dehydrogenase family MIPOCGNA_00193 322159.STER_1240 4.8e-28 129.8 Bacteria 6.3.2.2,6.3.2.4 ko:K01919,ko:K01921 ko00270,ko00473,ko00480,ko00550,ko01100,ko01502,map00270,map00473,map00480,map00550,map01100,map01502 M00118 R00894,R01150,R10993 RC00064,RC00090,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011 Bacteria COG1181@1,COG1181@2 NA|NA|NA F Belongs to the D-alanine--D-alanine ligase family MIPOCGNA_00194 322159.STER_1239 1.9e-176 625.2 Bacilli yfmL GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 ko:K05592,ko:K18692 ko03018,map03018 ko00000,ko00001,ko01000,ko03009,ko03019 Bacteria 1TQ9R@1239,4HANR@91061,COG0513@1,COG0513@2 NA|NA|NA L DEAD DEAH box helicase MIPOCGNA_00195 264199.stu1260 2.1e-114 418.3 Bacilli udk GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009224,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0043771,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046035,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.1.48 ko:K00876 ko00240,ko00983,ko01100,map00240,map00983,map01100 R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232 RC00002,RC00017 ko00000,ko00001,ko01000 iSBO_1134.SBO_0893 Bacteria 1TQ4V@1239,4HAVR@91061,COG0572@1,COG0572@2 NA|NA|NA F Cytidine monophosphokinase MIPOCGNA_00196 264199.stu1259 0.0 1203.3 Bacilli uup ko:K06158 ko00000,ko03012 Bacteria 1TPAX@1239,4HBVV@91061,COG0488@1,COG0488@2 NA|NA|NA S abc transporter atp-binding protein MIPOCGNA_00198 264199.stu1257 3.1e-130 471.1 Bacilli pip 1.11.1.10 ko:K00433 ko00000,ko01000 Bacteria 1V02M@1239,4HN2K@91061,COG0596@1,COG0596@2 NA|NA|NA S Alpha beta hydrolase MIPOCGNA_00199 264199.stu1256 0.0 1645.6 Bacilli mprF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.3.2.3 ko:K07027,ko:K14205 ko01503,ko02020,ko05150,map01503,map02020,map05150 M00726 ko00000,ko00001,ko00002,ko01000,ko01504,ko02000 2.A.1.3.37,4.D.2 iYO844.BG12900 Bacteria 1TQI2@1239,4HBHU@91061,COG0392@1,COG0392@2,COG2898@1,COG2898@2 NA|NA|NA J Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms MIPOCGNA_00200 264199.stu1255 8.7e-150 536.2 Bacilli cobQ ko:K07009 ko00000 Bacteria 1U7I9@1239,4HD1P@91061,COG3442@1,COG3442@2 NA|NA|NA S glutamine amidotransferase MIPOCGNA_00201 264199.stu1254 7e-253 879.4 Bacilli murD 3.4.21.10,6.3.2.13,6.3.2.9 ko:K01317,ko:K01925,ko:K01928,ko:K01932 ko00300,ko00471,ko00550,ko01100,map00300,map00471,map00550,map01100 R02783,R02788 RC00064,RC00090,RC00141 ko00000,ko00001,ko01000,ko01002,ko01011,ko04131 Bacteria 1UHPI@1239,4HVP0@91061,COG0771@1,COG0771@2 NA|NA|NA M Mur ligase, middle domain protein MIPOCGNA_00202 264199.stu1253 2.8e-123 448.0 Bacilli dacA GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009975,GO:0016020,GO:0016021,GO:0016829,GO:0016849,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 2.7.7.85 ko:K18672 ko00000,ko01000 Bacteria 1TPRW@1239,4H9XZ@91061,COG1624@1,COG1624@2 NA|NA|NA S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria MIPOCGNA_00203 322159.STER_1231 4.3e-167 594.0 Bacilli ybbR GO:0008150,GO:0031279,GO:0031281,GO:0043085,GO:0044093,GO:0045761,GO:0045762,GO:0050790,GO:0051339,GO:0051349,GO:0065007,GO:0065009 Bacteria 1TSIV@1239,4HD8Y@91061,COG4856@1,COG4856@2 NA|NA|NA S Protein conserved in bacteria MIPOCGNA_00204 264199.stu1251 8.2e-249 865.9 Bacilli glmM GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006468,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008966,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019538,GO:0034641,GO:0034654,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046777,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 R02060 RC00408 ko00000,ko00001,ko01000 iSB619.SA_RS11275,iSBO_1134.SBO_3206 Bacteria 1TP1X@1239,4HB16@91061,COG1109@1,COG1109@2 NA|NA|NA G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate MIPOCGNA_00205 264199.stu1250 1.3e-70 272.3 Bacilli gtrA GO:0000166,GO:0003674,GO:0003824,GO:0003870,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008883,GO:0009058,GO:0009987,GO:0016020,GO:0016410,GO:0016491,GO:0016620,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016749,GO:0016903,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0036094,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 Bacteria 1VMS6@1239,4HNB7@91061,COG2246@1,COG2246@2 NA|NA|NA S GtrA-like protein MIPOCGNA_00206 264199.stu1249 3.5e-123 447.6 Bacilli trmK GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.217 ko:K06967 ko00000,ko01000,ko03016 Bacteria 1V3I4@1239,4HHIM@91061,COG2384@1,COG2384@2 NA|NA|NA S SAM-dependent methyltransferase MIPOCGNA_00207 264199.stu1248 9.6e-149 532.7 Bacilli yqfO GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.5.4.16 ko:K22391 ko00790,ko01100,map00790,map01100 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQ27@1239,4H9NY@91061,COG0327@1,COG0327@2 NA|NA|NA S Belongs to the GTP cyclohydrolase I type 2 NIF3 family MIPOCGNA_00208 1046629.Ssal_01342 7e-22 109.4 Bacilli zupT ko:K07238 ko00000,ko02000 2.A.5.5 Bacteria 1TP7J@1239,4HB3R@91061,COG0428@1,COG0428@2 NA|NA|NA P Mediates zinc uptake. May also transport other divalent cations MIPOCGNA_00209 1046629.Ssal_01342 2.3e-100 371.7 Bacilli zupT ko:K07238 ko00000,ko02000 2.A.5.5 Bacteria 1TP7J@1239,4HB3R@91061,COG0428@1,COG0428@2 NA|NA|NA P Mediates zinc uptake. May also transport other divalent cations MIPOCGNA_00210 264199.stu1245 4.5e-205 720.3 Bacilli yurR GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0044424,GO:0044464,GO:0055114 1.4.5.1 ko:K00285 ko00360,map00360 R01374,R09493 RC00006,RC00025 ko00000,ko00001,ko01000 Bacteria 1TQTF@1239,4HA0F@91061,COG0665@1,COG0665@2 NA|NA|NA E oxidoreductase MIPOCGNA_00211 264199.stu1244 5.4e-161 573.5 Bacilli rfbA GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0005996,GO:0006006,GO:0006139,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008879,GO:0009058,GO:0009059,GO:0009117,GO:0009141,GO:0009147,GO:0009200,GO:0009211,GO:0009219,GO:0009225,GO:0009226,GO:0009262,GO:0009394,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019299,GO:0019300,GO:0019305,GO:0019318,GO:0019319,GO:0019438,GO:0019637,GO:0019692,GO:0030312,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0045226,GO:0046075,GO:0046364,GO:0046379,GO:0046383,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv0334 Bacteria 1V301@1239,4H9R0@91061,COG1209@1,COG1209@2 NA|NA|NA M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis MIPOCGNA_00212 264199.stu1243 2.7e-111 407.9 Bacilli rmlC 1.1.1.133,5.1.3.13 ko:K00067,ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777,R06514 RC00182,RC01531 ko00000,ko00001,ko00002,ko01000 Bacteria 1TRVB@1239,4HFQB@91061,COG1898@1,COG1898@2 NA|NA|NA M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose MIPOCGNA_00213 264199.stu1242 9.6e-205 719.2 Bacilli rfbB GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0008460,GO:0009058,GO:0009059,GO:0009987,GO:0016051,GO:0016829,GO:0016835,GO:0016836,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0045226,GO:0046379,GO:0071704,GO:1901576 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPWM@1239,4HA3Y@91061,COG1088@1,COG1088@2 NA|NA|NA M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily MIPOCGNA_00216 322159.STER_1755 1.7e-221 775.0 Bacilli pgk GO:0001871,GO:0002020,GO:0003674,GO:0003824,GO:0004618,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009893,GO:0009986,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019222,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030162,GO:0030193,GO:0030195,GO:0030246,GO:0030247,GO:0030312,GO:0031323,GO:0031325,GO:0032101,GO:0032102,GO:0032268,GO:0032270,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043532,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0045862,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048518,GO:0048519,GO:0048522,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050818,GO:0050819,GO:0050878,GO:0051171,GO:0051173,GO:0051186,GO:0051188,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051917,GO:0051919,GO:0055086,GO:0060255,GO:0061041,GO:0061045,GO:0065007,GO:0065008,GO:0070613,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0080134,GO:0090407,GO:1900046,GO:1900047,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903034,GO:1903035,GO:1903317,GO:1903319,GO:2001065 2.7.2.3,5.3.1.1 ko:K00927,ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01015,R01512 RC00002,RC00043,RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 iSB619.SA_RS04145 Bacteria 1TP3H@1239,4H9R3@91061,COG0126@1,COG0126@2 NA|NA|NA F Belongs to the phosphoglycerate kinase family MIPOCGNA_00217 904306.HMPREF9192_0265 1.5e-12 77.8 Bacteria Bacteria COG3464@1,COG3464@2 NA|NA|NA MIPOCGNA_00218 322159.STER_1753 1.3e-87 328.9 Bacilli Bacteria 1VAJG@1239,4HKDZ@91061,COG4129@1,COG4129@2 NA|NA|NA S Fusaric acid resistance protein-like MIPOCGNA_00219 322159.STER_1752 8.5e-63 246.1 Bacilli glnR GO:0003674,GO:0005488,GO:0005515,GO:0006082,GO:0006355,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016053,GO:0019219,GO:0019222,GO:0019752,GO:0031323,GO:0031326,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1903506,GO:2000112,GO:2001141 ko:K03713,ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 ko00000,ko00001,ko00002,ko02000,ko03000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 1V6JE@1239,4HKM6@91061,COG0789@1,COG0789@2 NA|NA|NA K Transcriptional regulator MIPOCGNA_00220 264199.stu1776 9.9e-263 912.1 Bacilli glnA 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 Bacteria 1TNZA@1239,4HACE@91061,COG0174@1,COG0174@2 NA|NA|NA E glutamine synthetase MIPOCGNA_00222 435842.HMPREF0848_01440 7.1e-41 173.3 Bacilli pscB Bacteria 1V8WM@1239,4HIMT@91061,COG3942@1,COG3942@2 NA|NA|NA M CHAP domain protein MIPOCGNA_00223 264199.stu1774 0.0 1109.0 Bacilli rnjA GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004527,GO:0004532,GO:0004534,GO:0004540,GO:0005488,GO:0005515,GO:0006139,GO:0006364,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008409,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042802,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0090503,GO:0140098,GO:1901360 ko:K12574 ko03018,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 1TQ9G@1239,4HAAP@91061,COG0595@1,COG0595@2 NA|NA|NA S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay MIPOCGNA_00224 264199.stu1773 2.5e-33 147.5 Bacilli ykzG Bacteria 1VEI7@1239,4HNSK@91061,COG5503@1,COG5503@2 NA|NA|NA S Belongs to the UPF0356 family MIPOCGNA_00225 322159.STER_1747 2.1e-120 438.3 Bacilli yeaZ GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 ko:K01409,ko:K14742 R10648 RC00070,RC00416 ko00000,ko01000,ko03016 Bacteria 1V4YX@1239,4HHD7@91061,COG1214@1,COG1214@2 NA|NA|NA O COG1214, inactive homolog of metal-dependent proteases MIPOCGNA_00226 264199.stu1771 1.3e-73 282.3 Bacilli rimI 2.3.1.128 ko:K03789 ko00000,ko01000,ko03009 Bacteria 1V6KU@1239,4HP50@91061,COG0454@1,COG0456@2 NA|NA|NA K This enzyme acetylates the N-terminal alanine of ribosomal protein S18 MIPOCGNA_00227 264199.stu1770 1.9e-186 658.3 Bacilli tsaD GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 ko:K01409,ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 R10648 RC00070,RC00416 ko00000,ko00001,ko00002,ko01000,ko02044,ko03016 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 Bacteria 1TQDR@1239,4HANB@91061,COG0533@1,COG0533@2 NA|NA|NA O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction MIPOCGNA_00228 264199.stu1769 8.5e-117 426.4 Bacilli azlC Bacteria 1V64T@1239,4HH44@91061,COG1296@1,COG1296@2 NA|NA|NA E AzlC protein MIPOCGNA_00229 264199.stu1768 8.8e-48 196.1 Bacteria azlD Bacteria COG4392@1,COG4392@2 NA|NA|NA E branched-chain amino acid MIPOCGNA_00230 264199.stu1767 0.0 1622.4 Bacilli recD2 3.1.11.5 ko:K03581 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 1TPZH@1239,4HATQ@91061,COG0507@1,COG0507@2 NA|NA|NA L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity MIPOCGNA_00231 264199.stu1766 1.3e-113 415.6 Bacilli lepB 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 ko00000,ko00001,ko01000,ko01002 Bacteria 1V7H9@1239,4HJSP@91061,COG0681@1,COG0681@2 NA|NA|NA U Belongs to the peptidase S26 family MIPOCGNA_00232 322159.STER_1740 4.7e-160 570.5 Bacilli rnhC GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03470,ko:K03471 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Bacteria 1TQBE@1239,4H9QR@91061,COG1039@1,COG1039@2 NA|NA|NA L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids MIPOCGNA_00233 1302863.I872_01550 2.3e-13 81.3 Bacilli zapA GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0000921,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032185,GO:0032505,GO:0032506,GO:0034622,GO:0042802,GO:0043093,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0051301,GO:0061640,GO:0065003,GO:0070925,GO:0071840,GO:0090529,GO:1902410,GO:1903047 ko:K09888 ko00000,ko03036 Bacteria 1VFZS@1239,4HP4T@91061,COG3027@1,COG3027@2 NA|NA|NA D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division MIPOCGNA_00234 322159.STER_1738 1e-93 349.4 Bacteria cvpA GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009403,GO:0009404,GO:0009987,GO:0016020,GO:0019748,GO:0044237,GO:0044249,GO:0044464,GO:0044550,GO:0071944 ko:K03558 ko00000 Bacteria COG1286@1,COG1286@2 NA|NA|NA S toxin biosynthetic process MIPOCGNA_00235 322159.STER_1737 0.0 1494.6 Bacilli mutS2 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 ko:K07456 ko03430,map03430 ko00000,ko00001,ko03400 Bacteria 1TP5W@1239,4H9NZ@91061,COG1193@1,COG1193@2 NA|NA|NA L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity MIPOCGNA_00236 322159.STER_1736 0.0 1710.7 Bacilli polA GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 Bacteria 1TPKJ@1239,4H9S7@91061,COG0258@1,COG0258@2,COG0749@1,COG0749@2 NA|NA|NA L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity MIPOCGNA_00240 264199.stu1757 2.3e-228 797.7 Bacilli mutY ko:K03575 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 1TPUT@1239,4H9UM@91061,COG1194@1,COG1194@2 NA|NA|NA L A G-specific adenine glycosylase MIPOCGNA_00241 996306.SSUR61_1077 2.8e-41 176.0 Streptococcus suis XK27_05745 Bacteria 1U8WY@1239,1WSBS@1307,2BJFN@1,32DS8@2,4IIVI@91061 NA|NA|NA MIPOCGNA_00242 264199.stu1754 1.9e-46 191.4 Bacilli rpsF GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904 ko:K02990 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011,ko03029 Bacteria 1VA18@1239,4HKHD@91061,COG0360@1,COG0360@2 NA|NA|NA J Binds together with S18 to 16S ribosomal RNA MIPOCGNA_00243 264199.stu1753 2.7e-91 341.3 Bacilli ssb ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 ko00000,ko00001,ko03029,ko03032,ko03400 Bacteria 1V3WT@1239,4HH8I@91061,COG0629@1,COG0629@2 NA|NA|NA L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism MIPOCGNA_00244 264199.stu1752 9.7e-36 155.6 Bacilli rpsR GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02963,ko:K03111,ko:K15125 ko03010,ko03030,ko03430,ko03440,ko05133,map03010,map03030,map03430,map03440,map05133 M00178 br01610,ko00000,ko00001,ko00002,ko00536,ko03011,ko03029,ko03032,ko03400 Bacteria 1V9XS@1239,4HKCC@91061,COG0238@1,COG0238@2 NA|NA|NA J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit MIPOCGNA_00246 322159.STER_1724 2e-123 448.4 Bacilli XK27_01040 Bacteria 1VF5N@1239,4HJMB@91061,COG4858@1,COG4858@2 NA|NA|NA S Pfam PF06570 MIPOCGNA_00247 264199.stu1749 5e-168 597.0 Bacilli corA ko:K03284 ko00000,ko02000 1.A.35.1,1.A.35.3 Bacteria 1TPI8@1239,4HE7S@91061,COG0598@1,COG0598@2 NA|NA|NA P COG0598 Mg2 and Co2 transporters MIPOCGNA_00248 322159.STER_1722 0.0 1867.8 Bacilli uvrA ko:K03701 ko03420,map03420 ko00000,ko00001,ko03400 Bacteria 1TPIJ@1239,4HAW9@91061,COG0178@1,COG0178@2 NA|NA|NA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate MIPOCGNA_00254 435842.HMPREF0848_01406 1.3e-58 232.3 Firmicutes ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TPBQ@1239,COG1131@1,COG1131@2 NA|NA|NA V 'abc transporter, ATP-binding protein MIPOCGNA_00255 904306.HMPREF9192_0620 6.9e-12 75.9 Firmicutes ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TPBQ@1239,COG1131@1,COG1131@2 NA|NA|NA V 'abc transporter, ATP-binding protein MIPOCGNA_00258 264199.stu1742 7.2e-192 676.4 Bacilli pepP GO:0003674,GO:0003824,GO:0004177,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.11.9,3.4.13.9 ko:K01262,ko:K01271,ko:K08326 ko00000,ko01000,ko01002 Bacteria 1TQ44@1239,4HAT7@91061,COG0006@1,COG0006@2 NA|NA|NA E Belongs to the peptidase M24B family MIPOCGNA_00259 264199.stu1741 1.1e-83 315.8 Bacilli comEB 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 Bacteria 1V8V0@1239,4IQZA@91061,COG2131@1,COG2131@2 NA|NA|NA F ComE operon protein 2 MIPOCGNA_00260 264199.stu1740 9.3e-98 362.8 Bacilli efp GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02356 ko00000,ko03012 Bacteria 1TR8P@1239,4H9YX@91061,COG0231@1,COG0231@2 NA|NA|NA J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase MIPOCGNA_00261 322159.STER_1714 3.4e-62 244.2 Bacilli yqhY ko:K10947 ko00000,ko03000 Bacteria 1V4IC@1239,4HJ7T@91061,COG1302@1,COG1302@2 NA|NA|NA S protein conserved in bacteria MIPOCGNA_00262 264199.stu1738 3.6e-73 280.8 Bacilli nusB ko:K03625 ko00000,ko03009,ko03021 Bacteria 1VA9B@1239,4HKMU@91061,COG0781@1,COG0781@2 NA|NA|NA K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons MIPOCGNA_00263 322159.STER_1712 2.4e-178 631.3 Bacilli scrR ko:K02529,ko:K03484 ko00000,ko03000 Bacteria 1TQ7K@1239,4H9V1@91061,COG1609@1,COG1609@2 NA|NA|NA K Transcriptional MIPOCGNA_00264 322159.STER_1711 2.7e-290 1003.8 Bacilli scrB 3.2.1.26 ko:K01193 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00801,R00802,R02410,R03635,R03921,R06088 RC00028,RC00077 ko00000,ko00001,ko01000 GH32 Bacteria 1TPAE@1239,4H9Y7@91061,COG1621@1,COG1621@2 NA|NA|NA G invertase MIPOCGNA_00265 264199.stu1734 0.0 1200.3 Bacilli scrA 2.7.1.208,2.7.1.211 ko:K02756,ko:K02777,ko:K02808,ko:K02809,ko:K02810,ko:K20107,ko:K20108 ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111 M00265,M00266,M00268,M00269,M00270,M00271,M00272,M00303,M00806 R00811,R02738,R02780,R04111,R04394,R05132,R08559 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.1,4.A.1.1.11,4.A.1.1.12,4.A.1.2.1,4.A.1.2.10,4.A.1.2.11,4.A.1.2.12,4.A.1.2.2,4.A.1.2.5,4.A.1.2.6,4.A.1.2.9 Bacteria 1TP5X@1239,4HA0I@91061,COG1263@1,COG1263@2,COG1264@1,COG1264@2,COG2190@1,COG2190@2 NA|NA|NA G pts system MIPOCGNA_00266 264199.stu1733 5.6e-34 149.8 Bacilli scrK 2.7.1.2,2.7.1.4 ko:K00845,ko:K00847 ko00010,ko00051,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R00760,R00867,R01600,R01786,R03920 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQU4@1239,4HA1C@91061,COG1940@1,COG1940@2 NA|NA|NA GK Fructokinase MIPOCGNA_00267 264199.stu1305 9e-278 962.2 Bacilli cls ko:K06131,ko:K06915 ko00564,ko01100,map00564,map01100 R07390 RC00017 ko00000,ko00001,ko01000 Bacteria 1TPKY@1239,4H9TI@91061,COG1502@1,COG1502@2 NA|NA|NA I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol MIPOCGNA_00268 322159.STER_1280 0.0 1182.9 Bacilli uvrC GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 ko:K03703 ko03420,map03420 ko00000,ko00001,ko03400 Bacteria 1TP4B@1239,4H9QH@91061,COG0322@1,COG0322@2 NA|NA|NA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision MIPOCGNA_00269 264199.stu1307 1.6e-20 105.1 Firmicutes yjjG GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006206,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008655,GO:0009058,GO:0009112,GO:0009410,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019856,GO:0019859,GO:0030145,GO:0034641,GO:0034654,GO:0042221,GO:0042578,GO:0043094,GO:0043100,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046112,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 3.1.3.102,3.1.3.104,3.1.3.5,3.8.1.2 ko:K01560,ko:K07025,ko:K08723,ko:K20862 ko00230,ko00240,ko00361,ko00625,ko00740,ko00760,ko01100,ko01110,ko01120,map00230,map00240,map00361,map00625,map00740,map00760,map01100,map01110,map01120 M00125 R00183,R00511,R00548,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346,R05287,R07280 RC00017,RC00697 ko00000,ko00001,ko00002,ko01000 iECNA114_1301.ECNA114_4614 Bacteria 1TWM7@1239,COG1011@1,COG1011@2 NA|NA|NA E hydrolase MIPOCGNA_00270 264199.stu1309 2e-88 332.0 Bacilli proW ko:K05846 ko02010,map02010 M00209 ko00000,ko00001,ko00002,ko02000 3.A.1.12 Bacteria 1V24D@1239,4IQR7@91061,COG1174@1,COG1174@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component MIPOCGNA_00271 264199.stu1310 1.6e-137 495.4 Bacilli proV ko:K05847 ko02010,map02010 M00209 ko00000,ko00001,ko00002,ko02000 3.A.1.12 Bacteria 1TPV8@1239,4H9SI@91061,COG1125@1,COG1125@2 NA|NA|NA E abc transporter atp-binding protein MIPOCGNA_00272 264199.stu1311 3.8e-165 587.4 Bacilli proX ko:K05845 ko02010,map02010 M00209 ko00000,ko00001,ko00002,ko02000 3.A.1.12 Bacteria 1TQ7D@1239,4HESS@91061,COG1732@1,COG1732@2 NA|NA|NA M ABC transporter, substrate-binding protein, QAT family MIPOCGNA_00273 264199.stu1312 2.3e-103 381.7 Bacilli proWZ ko:K05846 ko02010,map02010 M00209 ko00000,ko00001,ko00002,ko02000 3.A.1.12 Bacteria 1V41S@1239,4HH8U@91061,COG1174@1,COG1174@2 NA|NA|NA P ABC transporter (Permease MIPOCGNA_00274 264199.stu1313 2.5e-278 964.1 Bacilli hutH 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPCW@1239,4H9YS@91061,COG2986@1,COG2986@2 NA|NA|NA E Histidine ammonia-lyase MIPOCGNA_00275 264199.stu1314 1.6e-205 721.8 Bacilli ko:K09703 ko00000 Bacteria 1TR39@1239,4HBM2@91061,COG3535@1,COG3535@2 NA|NA|NA S Protein of unknown function (DUF917) MIPOCGNA_00276 264199.stu1315 2.5e-308 1063.9 Bacilli hutU 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPZ9@1239,4H9NH@91061,COG2987@1,COG2987@2 NA|NA|NA E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate MIPOCGNA_00277 264199.stu1316 4.6e-59 234.2 Bacilli sdaAB 4.3.1.17 ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 R00220,R00590 RC00331,RC02600 ko00000,ko00001,ko01000 Bacteria 1U8TZ@1239,4HBD6@91061,COG1760@1,COG1760@2 NA|NA|NA E L-serine dehydratase MIPOCGNA_00278 904306.HMPREF9192_1103 1.3e-100 372.5 Bacilli desR ko:K02479,ko:K07693 ko02020,map02020 M00479 ko00000,ko00001,ko00002,ko02022 Bacteria 1TVTF@1239,4HAJW@91061,COG2197@1,COG2197@2 NA|NA|NA K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain MIPOCGNA_00279 435842.HMPREF0848_00889 6e-186 656.8 Bacilli desK GO:0003674,GO:0003824,GO:0004721,GO:0005488,GO:0005515,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0036211,GO:0042578,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564 2.7.13.3 ko:K07778 ko02020,map02020 M00479 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1TSUE@1239,4HB9N@91061,COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase MIPOCGNA_00280 322159.STER_1292 2.6e-132 478.0 Firmicutes yvfS ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1V1AU@1239,COG0842@1,COG0842@2 NA|NA|NA V ABC-2 type transporter MIPOCGNA_00281 435842.HMPREF0848_00891 7.4e-158 563.1 Bacilli XK27_09825 ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1UZ04@1239,4HDGQ@91061,COG1131@1,COG1131@2 NA|NA|NA V abc transporter atp-binding protein MIPOCGNA_00285 322159.STER_1296 3.3e-212 744.2 Bacilli Bacteria 1UG5D@1239,2ZBIK@2,4H9W5@91061,COG0477@1 NA|NA|NA EGP Major facilitator Superfamily MIPOCGNA_00286 322159.STER_1297 0.0 1530.8 Bacteria 2.7.7.73,2.7.7.80 ko:K03148,ko:K21029 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07459 RC00043 ko00000,ko00001,ko01000 Bacteria COG0476@1,COG0476@2,COG1164@1,COG1164@2 NA|NA|NA E metalloendopeptidase activity MIPOCGNA_00287 322159.STER_1299 7.9e-152 543.1 Bacilli mutR ko:K20373 ko02024,map02024 ko00000,ko00001,ko03000 Bacteria 1VBRX@1239,4HMPG@91061,COG1396@1,COG1396@2 NA|NA|NA K Transcriptional activator, Rgg GadR MutR family MIPOCGNA_00288 1121864.OMO_01808 4.6e-42 177.2 Bacilli 3.6.1.55 ko:K03574 ko00000,ko01000,ko03400 Bacteria 1UJTM@1239,4ITFG@91061,COG1051@1,COG1051@2 NA|NA|NA F NUDIX domain MIPOCGNA_00290 322159.STER_1302 3.7e-122 444.1 Bacilli Bacteria 1VG0A@1239,2DQZH@1,339IV@2,4HTJB@91061 NA|NA|NA S An automated process has identified a potential problem with this gene model MIPOCGNA_00291 435842.HMPREF0848_00905 6.1e-26 123.2 Firmicutes XK27_09825 ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1UZ04@1239,COG1131@1,COG1131@2 NA|NA|NA V 'abc transporter, ATP-binding protein MIPOCGNA_00292 1123300.AUIN01000013_gene1665 1.6e-14 86.7 Bacteria liaI ko:K11619 ko02020,map02020 M00754 ko00000,ko00001,ko00002 Bacteria COG4758@1,COG4758@2 NA|NA|NA KT membrane MIPOCGNA_00293 1123300.AUIN01000013_gene1665 5.8e-30 137.9 Bacteria liaI ko:K11619 ko02020,map02020 M00754 ko00000,ko00001,ko00002 Bacteria COG4758@1,COG4758@2 NA|NA|NA KT membrane MIPOCGNA_00294 322159.STER_1306 6e-99 366.7 Firmicutes XK27_05000 ko:K06940 ko00000 Bacteria 1V67G@1239,COG0727@1,COG0727@2 NA|NA|NA S Fe-S-cluster oxidoreductase MIPOCGNA_00295 322159.STER_1307 0.0 1143.6 Bacilli ko:K02004,ko:K19084 ko02010,ko02020,map02010,map02020 M00258,M00731,M00737 ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.134 Bacteria 1TR2D@1239,4H9SH@91061,COG0577@1,COG0577@2 NA|NA|NA V ABC transporter (permease) MIPOCGNA_00296 322159.STER_1308 1.9e-133 481.9 Bacilli macB2 ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TNZG@1239,4H9UT@91061,COG1136@1,COG1136@2 NA|NA|NA V ABC transporter, ATP-binding protein MIPOCGNA_00297 322159.STER_1309 6.2e-166 590.1 Bacilli Bacteria 1TQSG@1239,4HG2J@91061,COG0642@1,COG0642@2 NA|NA|NA T Histidine kinase MIPOCGNA_00298 904306.HMPREF9192_1091 2e-123 448.4 Bacilli Bacteria 1TR32@1239,4HAUJ@91061,COG0745@1,COG0745@2 NA|NA|NA KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain MIPOCGNA_00299 904306.HMPREF9192_1089 2e-77 295.0 Bacilli xpt GO:0003674,GO:0003824,GO:0006139,GO:0006166,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0043094,GO:0043101,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046128,GO:0046129,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.22,2.4.2.7 ko:K00759,ko:K03816 ko00230,ko01100,ko01110,map00230,map01100,map01110 R00190,R01229,R02142,R04378 RC00063,RC00122 ko00000,ko00001,ko01000,ko04147 iYO844.BSU22070 Bacteria 1V1DU@1239,4HFNW@91061,COG0503@1,COG0503@2 NA|NA|NA F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis MIPOCGNA_00300 904306.HMPREF9192_1088 3.3e-69 267.7 Bacilli pbuX GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006863,GO:0008150,GO:0015205,GO:0015851,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0042906,GO:0042907,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:1904823 ko:K03458,ko:K16169,ko:K16170 ko00000,ko02000 2.A.40,2.A.40.3.1,2.A.40.3.2 iSB619.SA_RS02140 Bacteria 1TNZZ@1239,4HBAM@91061,COG2233@1,COG2233@2 NA|NA|NA F xanthine permease MIPOCGNA_00301 264199.stu1340 9.2e-119 433.0 Bacilli pbuX GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006863,GO:0008150,GO:0015205,GO:0015851,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0042906,GO:0042907,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:1904823 ko:K02824,ko:K03458,ko:K16169,ko:K16170 ko00000,ko02000 2.A.40,2.A.40.1.1,2.A.40.1.2,2.A.40.3.1,2.A.40.3.2 iSB619.SA_RS02140 Bacteria 1TNZZ@1239,4HBAM@91061,COG2233@1,COG2233@2 NA|NA|NA F xanthine permease MIPOCGNA_00302 322159.STER_1313 4.5e-247 860.1 Bacilli norM GO:0003674,GO:0005215,GO:0006810,GO:0006855,GO:0008150,GO:0015238,GO:0015893,GO:0022857,GO:0042221,GO:0042493,GO:0042891,GO:0042895,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0055085 ko:K03327 ko00000,ko02000 2.A.66.1 Bacteria 1TP5U@1239,4HA4W@91061,COG0534@1,COG0534@2 NA|NA|NA V Multidrug efflux pump MIPOCGNA_00303 264199.stu1343 9.7e-188 662.5 Bacilli msrA 1.8.4.11,1.8.4.12 ko:K07304,ko:K07305,ko:K12267 ko00000,ko01000 Bacteria 1TQ3E@1239,4HAIV@91061,COG0225@1,COG0225@2,COG0229@1,COG0229@2 NA|NA|NA O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine MIPOCGNA_00304 322159.STER_1315 6.6e-235 819.7 Bacilli brnQ GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015188,GO:0015190,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015820,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0022857,GO:0034220,GO:0042221,GO:0042493,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903785,GO:1903825,GO:1905039 ko:K03311 ko00000 2.A.26 Bacteria 1TQIS@1239,4HAKA@91061,COG1114@1,COG1114@2 NA|NA|NA E Component of the transport system for branched-chain amino acids MIPOCGNA_00305 264199.stu1358 9.4e-65 252.7 Bacilli manA 5.3.1.8 ko:K01809 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01819 RC00376 ko00000,ko00001,ko00002,ko01000 Bacteria 1VRGI@1239,4HBFW@91061,COG1482@1,COG1482@2 NA|NA|NA G mannose-6-phosphate isomerase MIPOCGNA_00306 264199.stu1359 8.2e-57 226.1 Bacilli manA 5.3.1.8 ko:K01809 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01819 RC00376 ko00000,ko00001,ko00002,ko01000 Bacteria 1VRGI@1239,4HBFW@91061,COG1482@1,COG1482@2 NA|NA|NA G mannose-6-phosphate isomerase MIPOCGNA_00307 264199.stu1360 4.8e-25 119.8 Bacteria csbD Bacteria COG3237@1,COG3237@2 NA|NA|NA K CsbD-like MIPOCGNA_00308 264199.stu1361 1.1e-227 795.8 Bacilli yfnA ko:K03294 ko00000 2.A.3.2 Bacteria 1TQ4K@1239,4HA66@91061,COG0531@1,COG0531@2 NA|NA|NA E amino acid MIPOCGNA_00309 1046629.Ssal_00817 4e-69 267.7 Bacteria Bacteria COG5263@1,COG5263@2 NA|NA|NA S dextransucrase activity MIPOCGNA_00310 435842.HMPREF0848_00928 6.3e-14 82.8 Bacteria Bacteria COG5263@1,COG5263@2 NA|NA|NA S dextransucrase activity MIPOCGNA_00311 435842.HMPREF0848_00928 8.8e-39 166.0 Bacteria Bacteria COG5263@1,COG5263@2 NA|NA|NA S dextransucrase activity MIPOCGNA_00312 435842.HMPREF0848_00928 9.4e-139 499.6 Bacteria Bacteria COG5263@1,COG5263@2 NA|NA|NA S dextransucrase activity MIPOCGNA_00313 904306.HMPREF9192_0124 1.6e-84 318.9 Bacilli comA ko:K06147,ko:K06148,ko:K20344 ko02010,ko02024,map02010,map02024 ko00000,ko00001,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.112,3.A.1.21 Bacteria 1V77J@1239,4HAX2@91061,COG2274@1,COG2274@2 NA|NA|NA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain MIPOCGNA_00314 1046629.Ssal_01905 2.6e-47 194.5 Bacteria yhaI Bacteria COG3152@1,COG3152@2 NA|NA|NA L Membrane MIPOCGNA_00315 1046629.Ssal_01904 1e-55 222.6 Firmicutes Bacteria 1VCM1@1239,2E26M@1,32XD2@2 NA|NA|NA S Domain of unknown function (DUF4173) MIPOCGNA_00316 264199.stu0280 1.2e-94 352.4 Firmicutes ureI GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03191,ko:K22112 ko05120,map05120 ko00000,ko00001,ko02000 1.A.29.1.1,1.A.29.1.2,1.A.29.1.3,1.A.29.1.4,1.A.29.1.5,1.A.29.1.6 Bacteria 1VAKB@1239,29DTM@1,300RH@2 NA|NA|NA S AmiS/UreI family transporter MIPOCGNA_00317 264199.stu0281 7.6e-46 189.5 Bacilli ureA GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0019627,GO:0034641,GO:0042221,GO:0043419,GO:0043603,GO:0043605,GO:0044237,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0050896,GO:0051716,GO:0070887,GO:0071241,GO:0071248,GO:0071281,GO:0071704,GO:0071941,GO:1901564,GO:1901565,GO:1901575 3.5.1.5 ko:K01430,ko:K14048 ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120 R00131 RC02798,RC02806 ko00000,ko00001,ko01000 iYO844.BSU36660 Bacteria 1V7GU@1239,4HIJS@91061,COG0831@1,COG0831@2 NA|NA|NA E Belongs to the urease gamma subunit family MIPOCGNA_00318 1046629.Ssal_01901 7.8e-54 216.1 Bacilli ureB GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0019627,GO:0034641,GO:0042221,GO:0043419,GO:0043603,GO:0043605,GO:0044237,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0050896,GO:0051716,GO:0070887,GO:0071241,GO:0071248,GO:0071281,GO:0071704,GO:0071941,GO:1901564,GO:1901565,GO:1901575 3.5.1.5 ko:K01429,ko:K14048 ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120 R00131 RC02798,RC02806 ko00000,ko00001,ko01000 Bacteria 1VAIA@1239,4HM0I@91061,COG0832@1,COG0832@2 NA|NA|NA E Belongs to the urease beta subunit family MIPOCGNA_00319 904306.HMPREF9192_0116 0.0 1152.1 Bacilli ureC 3.5.1.5 ko:K01428 ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120 R00131 RC02798,RC02806 ko00000,ko00001,ko01000 Bacteria 1TPQP@1239,4HBTS@91061,COG0804@1,COG0804@2 NA|NA|NA E Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family MIPOCGNA_00320 1046629.Ssal_01898 6.6e-78 296.6 Bacteria ureE GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 ko:K03187 ko00000 Bacteria COG2371@1,COG2371@2 NA|NA|NA O enzyme active site formation MIPOCGNA_00321 264199.stu0285 5.3e-130 470.3 Bacilli ureF ko:K03188 ko00000 Bacteria 1V2H0@1239,4HKQE@91061,COG0830@1,COG0830@2 NA|NA|NA O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter MIPOCGNA_00322 1046629.Ssal_01896 9.5e-112 409.5 Bacilli ureG ko:K03189,ko:K04652 ko00000,ko03110 Bacteria 1TS00@1239,4HC5C@91061,COG0378@1,COG0378@2 NA|NA|NA KO Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG MIPOCGNA_00323 264199.stu0287 3.7e-159 567.4 Bacilli ureD ko:K03190 ko00000 Bacteria 1TVM2@1239,4HCED@91061,COG0829@1,COG0829@2 NA|NA|NA O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter MIPOCGNA_00324 322159.STER_0330 2.7e-177 627.9 Bacilli cbiM GO:0000041,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015675,GO:0016020,GO:0016021,GO:0030001,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 ko:K02007 ko02010,map02010 M00245,M00246 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 Bacteria 1TPEN@1239,4HARY@91061,COG0310@1,COG0310@2 NA|NA|NA P PDGLE domain MIPOCGNA_00325 264199.stu0289 3.7e-137 494.2 Firmicutes ko:K02008 ko02010,map02010 M00245,M00246 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 Bacteria 1V7YC@1239,COG0619@1,COG0619@2 NA|NA|NA P cobalt transport protein MIPOCGNA_00326 264199.stu0290 1.6e-131 475.3 Bacilli cbiO GO:0000041,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015675,GO:0016020,GO:0016021,GO:0030001,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 ko:K02006 ko02010,map02010 M00245,M00246 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 Bacteria 1V16T@1239,4HI15@91061,COG1122@1,COG1122@2 NA|NA|NA P ABC transporter MIPOCGNA_00327 322159.STER_0333 5.3e-153 547.0 Bacteria ko:K02030 M00236 ko00000,ko00002,ko02000 3.A.1.3 Bacteria COG0834@1,COG0834@2 NA|NA|NA ET amino acid transport MIPOCGNA_00328 264199.stu0292 0.0 1876.3 Bacilli Bacteria 1TPTH@1239,4HAHU@91061,COG1020@1,COG1020@2 NA|NA|NA Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall MIPOCGNA_00329 264199.stu0293 0.0 1097.0 Bacilli 3.3.1.1,3.6.1.55,3.6.1.67 ko:K01251,ko:K03574,ko:K19965 ko00270,ko00790,ko01100,map00270,map00790,map01100 M00035,M00126 R00192,R04638,R04936 RC00002,RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko03400,ko04147 Bacteria 1V1P7@1239,4HFQH@91061,COG0499@1,COG0499@2,COG1051@1,COG1051@2 NA|NA|NA F NUDIX domain MIPOCGNA_00330 264199.stu0294 3.8e-205 720.7 Firmicutes Bacteria 1UHQE@1239,COG0477@1,COG0477@2 NA|NA|NA EGP Transmembrane secretion effector MIPOCGNA_00331 264199.stu0296 4.5e-144 517.3 Bacteria ko:K02030 M00236 ko00000,ko00002,ko02000 3.A.1.3 Bacteria COG0834@1,COG0834@2 NA|NA|NA ET amino acid transport MIPOCGNA_00332 264199.stu0297 5.8e-158 563.5 Bacilli metQ ko:K02073 ko02010,map02010 M00238 ko00000,ko00001,ko00002,ko02000 3.A.1.24 Bacteria 1TQAS@1239,4HCTA@91061,COG1464@1,COG1464@2 NA|NA|NA M Belongs to the NlpA lipoprotein family MIPOCGNA_00333 904306.HMPREF9192_0106 1.8e-256 891.3 Bacilli dapE 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP2D@1239,4HB9G@91061,COG0624@1,COG0624@2 NA|NA|NA E COG0624, acetylornithine deacetylase succinyl-diaminopimelate desuccinylase and related deacylases MIPOCGNA_00334 264199.stu0301 5.2e-182 643.7 Bacilli metN ko:K02071 ko02010,map02010 M00238 ko00000,ko00001,ko00002,ko02000 3.A.1.24 Bacteria 1TPPN@1239,4H9VX@91061,COG1135@1,COG1135@2 NA|NA|NA P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system MIPOCGNA_00335 264199.stu0302 2e-97 362.1 Bacilli metI ko:K02072 ko02010,map02010 M00238 ko00000,ko00001,ko00002,ko02000 3.A.1.24 Bacteria 1V0GE@1239,4HFMB@91061,COG2011@1,COG2011@2 NA|NA|NA P ABC transporter (Permease MIPOCGNA_00336 264199.stu0303 6.1e-211 740.0 Bacilli sstT GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005295,GO:0005310,GO:0005342,GO:0005343,GO:0005416,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006835,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015077,GO:0015081,GO:0015171,GO:0015175,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015672,GO:0015711,GO:0015804,GO:0015849,GO:0016020,GO:0016021,GO:0017153,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0032329,GO:0034220,GO:0035725,GO:0044425,GO:0044464,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1903825,GO:1905039 ko:K07862 ko00000,ko02000 2.A.23.4 iAF1260.b3089,iBWG_1329.BWG_2799,iECDH10B_1368.ECDH10B_3265,iECDH1ME8569_1439.ECDH1ME8569_2984,iECH74115_1262.ECH74115_4404,iECIAI1_1343.ECIAI1_3235,iECO103_1326.ECO103_3834,iECO111_1330.ECO111_3911,iECO26_1355.ECO26_4192,iECP_1309.ECP_3180,iECSE_1348.ECSE_3370,iECSP_1301.ECSP_4063,iECUMN_1333.ECUMN_3573,iECW_1372.ECW_m3356,iECs_1301.ECs3971,iEKO11_1354.EKO11_0630,iETEC_1333.ETEC_3359,iEcDH1_1363.EcDH1_0612,iEcE24377_1341.EcE24377A_3557,iG2583_1286.G2583_3813,iJO1366.b3089,iJR904.b3089,iSFV_1184.SFV_3130,iSSON_1240.SSON_3242,iUMNK88_1353.UMNK88_3845,iWFL_1372.ECW_m3356,iY75_1357.Y75_RS16050,iYL1228.KPN_03517,iZ_1308.Z4442 Bacteria 1TPD2@1239,4HBEC@91061,COG3633@1,COG3633@2 NA|NA|NA E Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) MIPOCGNA_00337 322159.STER_0345 4.9e-159 567.0 Bacilli salL GO:0003674,GO:0003824,GO:0016740,GO:0016765 2.5.1.63,2.5.1.94 ko:K09134,ko:K21153,ko:K22205 ko00000,ko01000 Bacteria 1TSR3@1239,4HAW6@91061,COG1912@1,COG1912@2 NA|NA|NA S S-adenosyl-l-methionine hydroxide adenosyltransferase MIPOCGNA_00338 322159.STER_0346 8e-94 349.7 Bacilli ko:K16924,ko:K16927 M00582 ko00000,ko00002,ko02000 3.A.1.29,3.A.1.32 Bacteria 1V1GT@1239,4HGAE@91061,COG4720@1,COG4720@2 NA|NA|NA S UPF0397 protein MIPOCGNA_00339 322159.STER_0347 0.0 1090.9 Bacilli ykoD GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0008150,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085 ko:K02006,ko:K16786,ko:K16787 ko02010,map02010 M00245,M00246,M00582 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.18,3.A.1.22,3.A.1.23,3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 Bacteria 1TPH8@1239,4HAJM@91061,COG1122@1,COG1122@2 NA|NA|NA P abc transporter atp-binding protein MIPOCGNA_00340 322159.STER_0348 1.6e-149 535.4 Bacilli cbiQ ko:K16785,ko:K16786,ko:K16787 ko02010,map02010 M00582 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 iSB619.SA_RS14165 Bacteria 1TPMV@1239,4HBTW@91061,COG0619@1,COG0619@2 NA|NA|NA P cobalt transport MIPOCGNA_00341 264199.stu0312 0.0 1310.4 Bacilli tkt 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPIB@1239,4HADA@91061,COG0021@1,COG0021@2 NA|NA|NA G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate MIPOCGNA_00342 1123298.KB904063_gene687 1.4e-11 75.5 Bacilli ulaG GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0005996,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0008150,GO:0008152,GO:0009056,GO:0009109,GO:0009111,GO:0009987,GO:0016052,GO:0016054,GO:0016787,GO:0016788,GO:0019752,GO:0019852,GO:0019854,GO:0030145,GO:0035460,GO:0042365,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0046872,GO:0046914,GO:0051186,GO:0051187,GO:0052689,GO:0071704,GO:1901575 ko:K03476 ko00053,ko01100,ko01120,map00053,map01100,map01120 M00550 R07677 RC02793 ko00000,ko00001,ko00002,ko01000 iAF1260.b4192,iAPECO1_1312.APECO1_2200,iBWG_1329.BWG_3904,iEC55989_1330.EC55989_4749,iECDH10B_1368.ECDH10B_4387,iECH74115_1262.ECH74115_5708,iECIAI1_1343.ECIAI1_4425,iECIAI39_1322.ECIAI39_4657,iECO111_1330.ECO111_5022,iECO26_1355.ECO26_5358,iECSE_1348.ECSE_4490,iECSP_1301.ECSP_5292,iECUMN_1333.ECUMN_4725,iECW_1372.ECW_m4554,iEKO11_1354.EKO11_4120,iEcE24377_1341.EcE24377A_4752,iEcHS_1320.EcHS_A4436,iEcolC_1368.EcolC_3821,iJO1366.b4192,iUTI89_1310.UTI89_C4792,iWFL_1372.ECW_m4554,iY75_1357.Y75_RS21830,iYL1228.KPN_04585,ic_1306.c5280 Bacteria 1TSFV@1239,4HBNW@91061,COG2220@1,COG2220@2 NA|NA|NA S L-ascorbate 6-phosphate lactonase MIPOCGNA_00343 264199.stu0313 1.9e-121 441.8 Bacilli ktrA ko:K03499 ko00000,ko02000 2.A.38.1,2.A.38.4 Bacteria 1TQ9H@1239,4HBPH@91061,COG0569@1,COG0569@2 NA|NA|NA P COG0569 K transport systems, NAD-binding component MIPOCGNA_00344 322159.STER_0351 3.4e-242 844.0 Bacilli ko:K03498 ko00000,ko02000 2.A.38.1,2.A.38.4 Bacteria 1TQ4S@1239,4H9ME@91061,COG0168@1,COG0168@2 NA|NA|NA P COG0168 Trk-type K transport systems, membrane components MIPOCGNA_00345 264199.stu0315 3.1e-130 471.1 Bacilli rsmG GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 ko:K03501 ko00000,ko01000,ko03009,ko03036 Bacteria 1TPBT@1239,4HAAZ@91061,COG0357@1,COG0357@2 NA|NA|NA J Ribosomal RNA small subunit methyltransferase G MIPOCGNA_00346 322159.STER_0353 9e-90 336.3 Bacilli yceD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 ko:K07040 ko00000 Bacteria 1VB08@1239,4HME9@91061,COG1399@1,COG1399@2 NA|NA|NA K metal-binding, possibly nucleic acid-binding protein MIPOCGNA_00347 264199.stu0317 3.3e-121 441.0 Bacilli Bacteria 1TS81@1239,4H9NE@91061,COG0745@1,COG0745@2 NA|NA|NA T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain MIPOCGNA_00348 264199.stu0318 3e-276 957.2 Bacilli Bacteria 1UHQC@1239,4HWKS@91061,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor MIPOCGNA_00349 264199.stu0319 1e-81 309.3 Bacilli nrdR GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K07738 ko00000,ko03000 Bacteria 1V3JA@1239,4HGXA@91061,COG1327@1,COG1327@2 NA|NA|NA K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes MIPOCGNA_00350 264199.stu0320 1.9e-217 761.5 Bacteria dnaB ko:K03346 ko00000,ko03032 Bacteria COG3611@1,COG3611@2 NA|NA|NA L Replication initiation and membrane attachment MIPOCGNA_00351 264199.stu0321 8.9e-167 592.8 Bacilli dnaI GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 ko:K11144 ko00000,ko03032 Bacteria 1TPZX@1239,4HABS@91061,COG1484@1,COG1484@2 NA|NA|NA L Primosomal protein DnaI MIPOCGNA_00352 322159.STER_0359 1.1e-245 855.5 Bacilli der GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 1.1.1.399,1.1.1.95 ko:K00058,ko:K03977 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko03009,ko04147 Bacteria 1TPNM@1239,4HAJ6@91061,COG1160@1,COG1160@2 NA|NA|NA S GTPase that plays an essential role in the late steps of ribosome biogenesis MIPOCGNA_00353 904306.HMPREF9192_0086 4.2e-13 79.3 Bacilli yrdC 3.5.1.19 ko:K08281 ko00760,ko01100,map00760,map01100 R01268 RC00100 ko00000,ko00001,ko01000 Bacteria 1V70H@1239,4HJXC@91061,COG1335@1,COG1335@2 NA|NA|NA Q isochorismatase MIPOCGNA_00354 904306.HMPREF9192_0086 1.4e-27 128.6 Bacilli yrdC 3.5.1.19 ko:K08281 ko00760,ko01100,map00760,map01100 R01268 RC00100 ko00000,ko00001,ko01000 Bacteria 1V70H@1239,4HJXC@91061,COG1335@1,COG1335@2 NA|NA|NA Q isochorismatase MIPOCGNA_00355 1116231.SMA_0321 5.3e-62 243.4 Bacilli Bacteria 1TP4C@1239,4HAXJ@91061,COG3328@1,COG3328@2 NA|NA|NA L Transposase MIPOCGNA_00356 322159.STER_1163 8.7e-276 955.7 Bacilli pyk GO:0001871,GO:0003674,GO:0003824,GO:0004743,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006116,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009266,GO:0009408,GO:0009628,GO:0009986,GO:0009987,GO:0016043,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0019693,GO:0019752,GO:0022607,GO:0030246,GO:0030247,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:2001065 2.7.1.40,2.7.7.4 ko:K00873,ko:K00958 ko00010,ko00230,ko00261,ko00450,ko00620,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00261,map00450,map00620,map00920,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050,M00176,M00596 R00200,R00430,R00529,R01138,R01858,R02320,R04929 RC00002,RC00015,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 iECO103_1326.ECO103_1819,iPC815.YPO2393 Bacteria 1TPGG@1239,4H9VY@91061,COG0469@1,COG0469@2 NA|NA|NA G Belongs to the pyruvate kinase family MIPOCGNA_00357 264199.stu1197 2.2e-185 654.8 Bacilli pfkA GO:0003674,GO:0003824,GO:0003872,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006116,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008443,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019200,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046835,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061615,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.11 ko:K00850 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 iYO844.BSU29190 Bacteria 1TPF4@1239,4HAPN@91061,COG0205@1,COG0205@2 NA|NA|NA F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis MIPOCGNA_00358 322159.STER_1165 0.0 2008.8 Bacilli dnaE 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 1TPYG@1239,4H9T3@91061,COG0587@1,COG0587@2 NA|NA|NA L DNA polymerase MIPOCGNA_00359 264199.stu1199 1.3e-150 538.9 Bacilli sua5 2.7.7.87 ko:K07566 R10463 RC00745 ko00000,ko01000,ko03009,ko03016 Bacteria 1U3HQ@1239,4HFGZ@91061,COG0009@1,COG0009@2 NA|NA|NA J Belongs to the SUA5 family MIPOCGNA_00360 264199.stu1200 3.1e-112 411.0 Bacilli leuD 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1V1I6@1239,4HFTY@91061,COG0066@1,COG0066@2 NA|NA|NA E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate MIPOCGNA_00361 322159.STER_1168 6.8e-275 952.6 Bacilli leuC GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 iEcE24377_1341.EcE24377A_0075,iPC815.YPO0531,iSB619.SA_RS10700 Bacteria 1TPE5@1239,4HAWA@91061,COG0065@1,COG0065@2 NA|NA|NA E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate MIPOCGNA_00362 322159.STER_1169 2.5e-43 181.0 Bacteria ysdA Bacteria COG3326@1,COG3326@2 NA|NA|NA L Membrane MIPOCGNA_00363 264199.stu1202 6.6e-190 669.8 Bacilli leuB GO:0003674,GO:0003824,GO:0003862,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1TPEM@1239,4HATP@91061,COG0473@1,COG0473@2 NA|NA|NA CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate MIPOCGNA_00364 322159.STER_1171 5.9e-291 1006.1 Bacilli leuA 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS10690,iYO844.BSU28280 Bacteria 1TP4Y@1239,4HA6E@91061,COG0119@1,COG0119@2 NA|NA|NA E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) MIPOCGNA_00365 264199.stu1204 4.6e-131 473.8 Bacilli gpmA GO:0001871,GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009986,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030246,GO:0030247,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031,GO:2001065 5.4.2.11 ko:K01834 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 Bacteria 1TQFP@1239,4HAW7@91061,COG0588@1,COG0588@2 NA|NA|NA G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate MIPOCGNA_00366 322159.STER_1173 2.5e-180 637.9 Bacilli pyrD GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.98.1 ko:K00226,ko:K02823,ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01867,R01869 RC00051 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPFV@1239,4HBFE@91061,COG0167@1,COG0167@2 NA|NA|NA F Catalyzes the conversion of dihydroorotate to orotate MIPOCGNA_00368 264199.stu1209 2.8e-39 167.5 Bacilli hup ko:K03530 ko00000,ko03032,ko03036,ko03400 Bacteria 1V9XQ@1239,4HKF2@91061,COG0776@1,COG0776@2 NA|NA|NA L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions MIPOCGNA_00369 904306.HMPREF9192_1574 1.3e-91 342.4 Bacilli ypmS Bacteria 1VF0K@1239,4HIYN@91061,COG4698@1,COG4698@2 NA|NA|NA S Protein conserved in bacteria MIPOCGNA_00370 264199.stu1211 1.3e-85 322.4 Bacteria ypmR GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0016298,GO:0016787,GO:0016788,GO:0052689 Bacteria COG2755@1,COG2755@2 NA|NA|NA E lipolytic protein G-D-S-L family MIPOCGNA_00371 1046629.Ssal_01285 3.8e-45 187.6 Bacilli ypmR GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0016298,GO:0016787,GO:0016788,GO:0052689 Bacteria 1V1HR@1239,4HDXS@91061,COG2755@1,COG2755@2 NA|NA|NA E COG2755 Lysophospholipase L1 and related esterases MIPOCGNA_00372 264199.stu1212 3.3e-147 527.7 Bacilli DegV Bacteria 1TRZ4@1239,4HBR8@91061,COG1307@1,COG1307@2 NA|NA|NA S DegV family MIPOCGNA_00373 322159.STER_1179 2.9e-304 1050.4 Bacilli recN GO:0000724,GO:0000725,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009295,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:1901360 ko:K03631,ko:K13582 ko04112,map04112 ko00000,ko00001,ko03400 Bacteria 1TP99@1239,4H9ZR@91061,COG0497@1,COG0497@2 NA|NA|NA L May be involved in recombinational repair of damaged DNA MIPOCGNA_00374 322159.STER_1180 3.7e-73 280.8 Bacilli argR GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 ko:K03402 ko00000,ko03000 Bacteria 1V1R7@1239,4HFY8@91061,COG1438@1,COG1438@2 NA|NA|NA K Regulates arginine biosynthesis genes MIPOCGNA_00375 264199.stu1215 4.7e-157 560.5 Bacilli rrmJ 2.1.1.226,2.1.1.227 ko:K06442 ko00000,ko01000,ko03009 Bacteria 1TPE4@1239,4HAPY@91061,COG1189@1,COG1189@2 NA|NA|NA J Ribosomal RNA large subunit methyltransferase J MIPOCGNA_00376 264199.stu1216 6.6e-159 566.6 Bacilli ispA GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0071704,GO:1901576 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 ko:K00795,ko:K02523,ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061,R09248 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 Bacteria 1TPQY@1239,4HA8E@91061,COG0142@1,COG0142@2 NA|NA|NA H Belongs to the FPP GGPP synthase family MIPOCGNA_00377 264199.stu1217 3.5e-29 133.7 Bacteria xseB 3.1.11.6 ko:K03602 ko03430,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria COG1722@1,COG1722@2 NA|NA|NA L exodeoxyribonuclease VII activity MIPOCGNA_00378 264199.stu1218 3.4e-247 860.5 Bacilli xseA 3.1.11.6 ko:K03601 ko03430,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 1TP4E@1239,4HAN2@91061,COG1570@1,COG1570@2 NA|NA|NA L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides MIPOCGNA_00379 1198676.SMUGS5_04945 2.5e-07 62.4 Bacteria Bacteria COG4640@1,COG4640@2 NA|NA|NA KT response to antibiotic MIPOCGNA_00381 264199.stu1220 3.4e-120 437.6 Bacilli nth 4.2.99.18 ko:K10773 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 1TRAK@1239,4HATD@91061,COG0177@1,COG0177@2 NA|NA|NA L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate MIPOCGNA_00382 264199.stu1221 1.5e-124 452.2 Bacteria dnaD ko:K02086 ko00000 Bacteria COG3935@1,COG3935@2 NA|NA|NA MIPOCGNA_00383 322159.STER_1189 1.3e-181 642.1 Bacilli metA GO:0003674,GO:0003824,GO:0008374,GO:0008899,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016750 2.3.1.46 ko:K00651 ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230 M00017 R01777 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQVR@1239,4H9W4@91061,COG1897@1,COG1897@2 NA|NA|NA E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine MIPOCGNA_00384 264199.stu1223 2e-94 351.7 Bacilli apt GO:0003674,GO:0003824,GO:0003999,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006168,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.22,2.4.2.7 ko:K00759,ko:K03816,ko:K09685 ko00230,ko01100,ko01110,map00230,map01100,map01110 R00190,R01229,R02142,R04378 RC00063,RC00122 ko00000,ko00001,ko01000,ko03000,ko04147 Bacteria 1V1BV@1239,4HFUA@91061,COG0503@1,COG0503@2 NA|NA|NA F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis MIPOCGNA_00385 322159.STER_1191 0.0 1435.2 Bacilli recJ ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 1TPXE@1239,4H9UP@91061,COG0608@1,COG0608@2,COG4199@1,COG4199@2 NA|NA|NA L Single-strand DNA-specific exonuclease, C terminal domain MIPOCGNA_00386 322159.STER_1192 9.7e-138 496.1 Bacilli XK27_05435 1.1.1.100 ko:K00059,ko:K07124 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 1TSJ3@1239,4HDU5@91061,COG0300@1,COG0300@2 NA|NA|NA S Belongs to the short-chain dehydrogenases reductases (SDR) family MIPOCGNA_00387 264199.stu1226 9.2e-175 619.4 Bacilli rnz GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004527,GO:0004532,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016891,GO:0016893,GO:0016896,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043169,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0090503,GO:0140098,GO:1901360,GO:1905267 3.1.26.11 ko:K00784 ko03013,map03013 ko00000,ko00001,ko01000,ko03016 Bacteria 1TRGP@1239,4HABM@91061,COG1234@1,COG1234@2 NA|NA|NA S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA MIPOCGNA_00388 264199.stu1227 3.9e-116 424.1 Bacilli galT 2.7.7.12 ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 M00362,M00554,M00632 R00955 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 1VY8D@1239,4HXPD@91061,COG4468@1,COG4468@2 NA|NA|NA G UDPglucose--hexose-1-phosphate uridylyltransferase MIPOCGNA_00389 264199.stu1228 2.7e-222 777.7 Bacilli hflX GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0043021,GO:0043022,GO:0044424,GO:0044464,GO:0044877 ko:K03665 ko00000,ko03009 Bacteria 1TNZB@1239,4HACA@91061,COG2262@1,COG2262@2 NA|NA|NA S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis MIPOCGNA_00390 322159.STER_1197 7.3e-232 809.7 Bacilli rodA ko:K05837 ko00000,ko03036 Bacteria 1TPGH@1239,4HAV4@91061,COG0772@1,COG0772@2 NA|NA|NA D Belongs to the SEDS family MIPOCGNA_00391 1046629.Ssal_01315 2e-49 201.4 Bacteria hisE GO:0000105,GO:0000287,GO:0003674,GO:0003824,GO:0004636,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052803,GO:0071704,GO:0071944,GO:0075136,GO:0075139,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.4.19,3.6.1.31,5.3.1.16 ko:K01523,ko:K01814,ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037,R04640 RC00002,RC00945,RC01055 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS14110,iYO844.BSU34860 Bacteria COG0140@1,COG0140@2 NA|NA|NA E phosphoribosyl-ATP diphosphatase activity MIPOCGNA_00392 322159.STER_1199 8e-60 236.1 Bacilli hisI GO:0000105,GO:0003674,GO:0003824,GO:0004635,GO:0004636,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.4.19,3.5.4.25,3.6.1.31,5.3.1.16 ko:K01496,ko:K01497,ko:K01814,ko:K11755 ko00340,ko00740,ko00790,ko01100,ko01110,ko01230,ko02024,map00340,map00740,map00790,map01100,map01110,map01230,map02024 M00026,M00125 R00425,R04035,R04037,R04640 RC00002,RC00293,RC00945,RC01055,RC02504 ko00000,ko00001,ko00002,ko01000 iECNA114_1301.ECNA114_0880,iECW_1372.ECW_m2186,iEKO11_1354.EKO11_1768,iHN637.CLJU_RS05760,iSB619.SA_RS14110,iUMN146_1321.UM146_06665,iWFL_1372.ECW_m2186 Bacteria 1UYNA@1239,4HA9R@91061,COG0139@1,COG0139@2 NA|NA|NA E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP MIPOCGNA_00393 322159.STER_1200 2e-135 488.4 Bacilli hisF GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009382,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 3.5.4.19,3.6.1.31 ko:K01663,ko:K02500,ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037,R04558 RC00002,RC00010,RC01055,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 iECO111_1330.ECO111_2749,iEcolC_1368.EcolC_1617,iHN637.CLJU_RS05755,iLJ478.TM1036,iSB619.SA_RS14115,iYL1228.KPN_02481 Bacteria 1TP0W@1239,4HAAM@91061,COG0107@1,COG0107@2 NA|NA|NA E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit MIPOCGNA_00394 322159.STER_1201 1.9e-127 461.8 Bacilli hisA GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_0388 Bacteria 1V1IR@1239,4HACP@91061,COG0106@1,COG0106@2 NA|NA|NA E 1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase MIPOCGNA_00395 322159.STER_1202 9.8e-109 399.4 Bacilli hisH ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQT0@1239,4HHNQ@91061,COG0118@1,COG0118@2 NA|NA|NA E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR MIPOCGNA_00396 322159.STER_1203 1.5e-106 392.1 Bacilli hisB GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0004424,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042578,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23,2.6.1.9,3.1.3.15,4.2.1.19 ko:K00013,ko:K00817,ko:K01089,ko:K01693 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R01158,R01163,R03012,R03013,R03243,R03457 RC00006,RC00017,RC00099,RC00242,RC00463,RC00888,RC00932 ko00000,ko00001,ko00002,ko01000,ko01007 iECO111_1330.ECO111_2746,iECS88_1305.ECS88_2121,iJN746.PP_0289,iLJ478.TM1039,iSB619.SA_RS14130,iUMNK88_1353.UMNK88_2570 Bacteria 1TRH7@1239,4HCFG@91061,COG0131@1,COG0131@2 NA|NA|NA E imidazoleglycerol-phosphate dehydratase MIPOCGNA_00397 322159.STER_1204 7.8e-233 812.8 Bacilli hisD GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23,1.1.1.308 ko:K00013,ko:K15509 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPAW@1239,4H9XK@91061,COG0141@1,COG0141@2 NA|NA|NA E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine MIPOCGNA_00398 322159.STER_1205 4e-116 424.1 Bacilli hisG GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 ko:K00765,ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 Bacteria 1TSVZ@1239,4H9MH@91061,COG0040@1,COG0040@2 NA|NA|NA E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity MIPOCGNA_00399 322159.STER_1206 5.7e-183 646.7 Bacilli hisZ 2.4.2.17,6.1.1.21 ko:K00765,ko:K01892,ko:K02502 ko00340,ko00970,ko01100,ko01110,ko01230,map00340,map00970,map01100,map01110,map01230 M00026,M00359,M00360 R01071,R03655 RC00055,RC00523,RC02819,RC03200 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1TPZZ@1239,4HBBA@91061,COG3705@1,COG3705@2 NA|NA|NA E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine MIPOCGNA_00400 322159.STER_1207 8.2e-196 689.5 Bacilli hisC 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 iJN678.hisC Bacteria 1TPUV@1239,4HA1H@91061,COG0079@1,COG0079@2 NA|NA|NA E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily MIPOCGNA_00401 1046629.Ssal_01470 2e-83 315.5 Bacilli norB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 ko:K08170,ko:K08218 ko01501,map01501 M00628,M00702 ko00000,ko00001,ko00002,ko01504,ko02000 2.A.1.25,2.A.1.3.23,2.A.1.3.59 Bacteria 1TPHW@1239,4H9YA@91061,COG0477@1,COG0477@2,COG2211@1,COG2211@2 NA|NA|NA P Major facilitator superfamily MIPOCGNA_00402 1154860.SAG0136_02950 4.3e-33 147.1 Firmicutes Bacteria 1TQ93@1239,COG3464@1,COG3464@2 NA|NA|NA L Transposase MIPOCGNA_00403 888833.HMPREF9421_0322 1.1e-99 369.4 Bacilli fic ko:K04095 ko00000,ko03036 Bacteria 1TPUZ@1239,4HIQT@91061,COG2184@1,COG2184@2 NA|NA|NA D Fic/DOC family MIPOCGNA_00404 862967.SIR_1564 6.5e-27 125.9 Streptococcus anginosus group Bacteria 1VPN1@1239,2ETKC@1,33M40@2,42EFP@671232,4I4M5@91061 NA|NA|NA MIPOCGNA_00405 1095738.HMPREF1047_1594 2.1e-60 238.8 Bacilli Bacteria 1UZAP@1239,28NE4@1,2ZBGP@2,4HFEW@91061 NA|NA|NA MIPOCGNA_00406 264199.stu1596 0.0 1489.6 Bacilli ctpE ko:K12952 ko00000,ko01000 3.A.3.23 Bacteria 1TPF5@1239,4H9ZI@91061,COG0474@1,COG0474@2 NA|NA|NA P E1-E2 ATPase MIPOCGNA_00407 1046629.Ssal_00451 1.1e-35 155.6 Bacilli Bacteria 1VCIA@1239,2C4MC@1,32RSW@2,4HKKA@91061 NA|NA|NA MIPOCGNA_00408 1046629.Ssal_00456 1.5e-35 155.2 Bacteria pchB 2.5.1.19,4.2.1.10,4.2.99.21,5.4.99.5 ko:K00800,ko:K03785,ko:K04092,ko:K04782 ko00400,ko01053,ko01100,ko01110,ko01130,ko01230,map00400,map01053,map01100,map01110,map01130,map01230 M00022,M00024,M00025 R01715,R03084,R03460,R06602 RC00350,RC00848,RC01549,RC02148,RC03116 ko00000,ko00001,ko00002,ko01000 Bacteria COG1605@1,COG1605@2 NA|NA|NA E Chorismate mutase MIPOCGNA_00409 904306.HMPREF9192_0786 4.6e-252 876.7 Bacilli trpE GO:0000162,GO:0003674,GO:0003824,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQAP@1239,4HB31@91061,COG0147@1,COG0147@2 NA|NA|NA EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia MIPOCGNA_00410 264199.stu1592 2e-103 381.7 Bacilli trpG 2.4.2.18,2.6.1.85,4.1.3.27 ko:K00766,ko:K01658,ko:K01664,ko:K13497 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01073,R01716 RC00010,RC00440,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 Bacteria 1V4RM@1239,4HHD8@91061,COG0512@1,COG0512@2 NA|NA|NA EH anthranilate MIPOCGNA_00411 322159.STER_1552 7.8e-180 636.3 Bacilli trpD GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 ko:K00766,ko:K13497 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01073 RC00010,RC00440,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP8U@1239,4H9KQ@91061,COG0547@1,COG0547@2 NA|NA|NA F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) MIPOCGNA_00412 322159.STER_1551 3.2e-133 481.1 Bacilli trpC GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48,5.3.1.24 ko:K01609,ko:K01817,ko:K13498 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508,R03509 RC00944,RC00945 ko00000,ko00001,ko00002,ko01000 Bacteria 1TR94@1239,4HG9K@91061,COG0134@1,COG0134@2 NA|NA|NA E Belongs to the TrpC family MIPOCGNA_00413 322159.STER_1550 1.1e-98 365.9 Bacilli trpF GO:0000162,GO:0003674,GO:0003824,GO:0004425,GO:0004640,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.48,4.2.1.160,4.2.1.20,5.3.1.24 ko:K01696,ko:K01817,ko:K13498,ko:K22100 ko00260,ko00400,ko00790,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map00790,map01100,map01110,map01130,map01230 M00023,M00840 R00674,R02340,R02722,R03508,R03509,R11072 RC00209,RC00210,RC00700,RC00701,RC00944,RC00945,RC02868,RC03343 ko00000,ko00001,ko00002,ko01000 iJN678.trpF,iPC815.YPO2205,iSBO_1134.SBO_1804,iSDY_1059.SDY_1330 Bacteria 1V6Y0@1239,4HK18@91061,COG0135@1,COG0135@2 NA|NA|NA E belongs to the TrpF family MIPOCGNA_00414 1046629.Ssal_00464 3.8e-229 800.4 Bacilli trpB GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20,5.3.1.24 ko:K01696,ko:K01817 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722,R03509 RC00209,RC00210,RC00700,RC00701,RC00945,RC02868 ko00000,ko00001,ko00002,ko01000 iYO844.BSU22640 Bacteria 1TPI3@1239,4H9WC@91061,COG0133@1,COG0133@2 NA|NA|NA E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine MIPOCGNA_00415 264199.stu1587 6e-143 513.5 Bacilli trpA 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPXA@1239,4HFQ8@91061,COG0159@1,COG0159@2 NA|NA|NA E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate MIPOCGNA_00416 322159.STER_1547 2.7e-73 281.2 Bacilli copY Bacteria 1VA7Q@1239,4HKGF@91061,COG3682@1,COG3682@2 NA|NA|NA K Copper transport repressor, CopY TcrY family MIPOCGNA_00417 322159.STER_1546 0.0 1315.4 Bacilli copA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 Bacteria 1TP5S@1239,4HAI0@91061,COG2217@1,COG2217@2 NA|NA|NA P P-type ATPase MIPOCGNA_00418 264199.stu1584 3e-30 137.1 Bacilli copZ GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006810,GO:0006811,GO:0006812,GO:0006873,GO:0006875,GO:0008150,GO:0009987,GO:0019725,GO:0030001,GO:0030003,GO:0042592,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0055065,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0098771 2.7.7.77 ko:K03752,ko:K07213,ko:K08364 ko00790,ko01100,ko04978,map00790,map01100,map04978 R11581 ko00000,ko00001,ko01000,ko02000 1.A.72.1 Bacteria 1VK5F@1239,4HR1Z@91061,COG2608@1,COG2608@2 NA|NA|NA P Heavy metal-associated domain protein MIPOCGNA_00419 322159.STER_1544 1.7e-193 681.8 Bacilli ddl 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 Bacteria 1TP2Y@1239,4H9KB@91061,COG1181@1,COG1181@2 NA|NA|NA F Belongs to the D-alanine--D-alanine ligase family MIPOCGNA_00420 264199.stu1582 3.9e-114 417.5 Bacilli papP ko:K02029 M00236 ko00000,ko00002,ko02000 3.A.1.3 Bacteria 1TRU3@1239,4HGE1@91061,COG0765@1,COG0765@2 NA|NA|NA P ABC transporter (Permease MIPOCGNA_00421 1046629.Ssal_00474 3e-106 391.3 Bacilli ko:K02029 M00236 ko00000,ko00002,ko02000 3.A.1.3 Bacteria 1TR7R@1239,4HGVA@91061,COG0765@1,COG0765@2 NA|NA|NA P ABC transporter (Permease MIPOCGNA_00422 264199.stu1580 1.7e-134 485.3 Bacilli glnQ 3.6.3.21 ko:K02028 M00236 ko00000,ko00002,ko01000,ko02000 3.A.1.3 Bacteria 1TNYD@1239,4HDK7@91061,COG1126@1,COG1126@2 NA|NA|NA E abc transporter atp-binding protein MIPOCGNA_00423 322159.STER_1539 1.1e-155 555.8 Bacilli cjaA ko:K02030 M00236 ko00000,ko00002,ko02000 3.A.1.3 Bacteria 1TT11@1239,4HFBQ@91061,COG0834@1,COG0834@2 NA|NA|NA ET ABC transporter substrate-binding protein MIPOCGNA_00426 322159.STER_1534 5.7e-258 896.3 Bacilli murF 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 Bacteria 1VT78@1239,4HACR@91061,COG0770@1,COG0770@2 NA|NA|NA M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein MIPOCGNA_00427 322159.STER_1533 7.1e-121 439.9 Bacteria ywaF Bacteria COG5522@1,COG5522@2 NA|NA|NA S Integral membrane protein (intg_mem_TP0381) MIPOCGNA_00428 322159.STER_1532 3.1e-300 1036.9 Bacilli prfC GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016150,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02837,ko:K07133 ko00000,ko03012 Bacteria 1TPYT@1239,4HADS@91061,COG4108@1,COG4108@2 NA|NA|NA J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP MIPOCGNA_00429 322159.STER_1531 1.4e-84 318.9 Bacilli yjbB ko:K08220 ko00000,ko02000 2.A.1.28.1,2.A.1.28.4 Bacteria 1TR4D@1239,4HDCY@91061,COG2211@1,COG2211@2 NA|NA|NA G Permeases of the major facilitator superfamily MIPOCGNA_00430 264199.stu1573 3.1e-64 251.1 Bacilli yjbB ko:K08220 ko00000,ko02000 2.A.1.28.1,2.A.1.28.4 Bacteria 1TR4D@1239,4HDCY@91061,COG2211@1,COG2211@2 NA|NA|NA G Permeases of the major facilitator superfamily MIPOCGNA_00431 322159.STER_1530 1.4e-153 548.9 Bacilli Z012_04635 Bacteria 1UZI0@1239,4HC2C@91061,COG1396@1,COG1396@2 NA|NA|NA K Transcriptional activator, Rgg GadR MutR family MIPOCGNA_00432 322159.STER_1529 5.6e-98 363.6 Bacilli thiT ko:K16789 ko00000,ko02000 2.A.88.3 Bacteria 1V6YE@1239,4HIJE@91061,COG3859@1,COG3859@2 NA|NA|NA S Thiamine transporter MIPOCGNA_00433 264199.stu1570 2.5e-62 244.6 Bacilli yjqA Bacteria 1V77G@1239,3172B@2,4HJ0W@91061,arCOG12631@1 NA|NA|NA S Bacterial PH domain MIPOCGNA_00434 264199.stu1569 7.4e-145 520.0 Bacilli corA ko:K03284 ko00000,ko02000 1.A.35.1,1.A.35.3 Bacteria 1TPI8@1239,4HCQ6@91061,COG0598@1,COG0598@2 NA|NA|NA P CorA-like protein MIPOCGNA_00435 322159.STER_1526 1.1e-239 835.9 Bacilli cshA GO:0000166,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0008026,GO:0008144,GO:0008150,GO:0008152,GO:0008186,GO:0009266,GO:0009295,GO:0009409,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901363 3.6.4.13 ko:K05592,ko:K18692 ko03018,map03018 ko00000,ko00001,ko01000,ko03009,ko03019 Bacteria 1TPAP@1239,4HAB3@91061,COG0513@1,COG0513@2 NA|NA|NA JKL DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity MIPOCGNA_00436 264199.stu1567 1e-41 175.6 Bacilli yazA ko:K07461 ko00000 Bacteria 1VEZF@1239,4HNHJ@91061,COG2827@1,COG2827@2 NA|NA|NA L endonuclease containing a URI domain MIPOCGNA_00437 322159.STER_1524 2.7e-140 504.6 Bacilli yabB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464 2.1.1.223 ko:K07461,ko:K15460 ko00000,ko01000,ko03016 Bacteria 1TQ25@1239,4HA8W@91061,COG4123@1,COG4123@2 NA|NA|NA L Methyltransferase MIPOCGNA_00438 435842.HMPREF0848_01183 1.8e-140 505.4 Bacilli nodB3 Bacteria 1TYRH@1239,4HHQN@91061,COG0726@1,COG0726@2 NA|NA|NA G deacetylase MIPOCGNA_00439 322159.STER_1522 1.7e-142 511.9 Bacilli plsC GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008374,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0042171,GO:0044464,GO:0071617,GO:0071944 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 1U8N2@1239,4HDQR@91061,COG0204@1,COG0204@2 NA|NA|NA I Acyltransferase MIPOCGNA_00440 322159.STER_1521 3e-98 364.8 Bacilli comEA ko:K02237 M00429 ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 Bacteria 1VA3W@1239,4HKJ1@91061,COG1555@1,COG1555@2 NA|NA|NA L COG1555 DNA uptake protein and related DNA-binding proteins MIPOCGNA_00441 322159.STER_1520 0.0 1442.2 Bacilli comEC ko:K02238 M00429 ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 Bacteria 1TS9U@1239,4H9M4@91061,COG0658@1,COG0658@2,COG2333@1,COG2333@2 NA|NA|NA S Competence protein ComEC MIPOCGNA_00442 322159.STER_1519 1.6e-233 815.1 Bacilli murA GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008760,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016765,GO:0030203,GO:0034645,GO:0042221,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0070589,GO:0070887,GO:0071236,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 R00660 RC00350 ko00000,ko00001,ko01000,ko01011 iYO844.BSU37100 Bacteria 1TPAU@1239,4H9KI@91061,COG0766@1,COG0766@2 NA|NA|NA M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine MIPOCGNA_00443 1123299.AUKZ01000014_gene1677 3.9e-17 94.7 Bacilli Bacteria 1TQN4@1239,4HN8F@91061,COG0358@1,COG0358@2,COG4227@1,COG4227@2 NA|NA|NA L Psort location Cytoplasmic, score MIPOCGNA_00446 264199.stu0329 8.6e-232 809.3 Bacilli serS GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004828,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006434,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0010467,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iAF987.Gmet_3528,iSDY_1059.SDY_2368 Bacteria 1TP4W@1239,4H9Y4@91061,COG0172@1,COG0172@2 NA|NA|NA J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) MIPOCGNA_00447 322159.STER_0369 4.2e-62 243.8 Bacilli manO Bacteria 1VF36@1239,4HPYI@91061,COG4687@1,COG4687@2 NA|NA|NA S protein conserved in bacteria MIPOCGNA_00448 264199.stu0331 6.2e-168 596.7 Bacilli manN ko:K02796 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 M00276 R02630 RC00017,RC03206 ko00000,ko00001,ko00002,ko02000 4.A.6.1 Bacteria 1TQA3@1239,4HA3K@91061,COG3716@1,COG3716@2 NA|NA|NA G PTS system mannose fructose sorbose family IID component MIPOCGNA_00449 322159.STER_0371 3.9e-116 424.5 Bacilli manM ko:K02795,ko:K02796 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 M00276 R02630 RC00017,RC03206 ko00000,ko00001,ko00002,ko02000 4.A.6.1 Bacteria 1TPKK@1239,4H9QI@91061,COG3715@1,COG3715@2 NA|NA|NA G pts system MIPOCGNA_00450 322159.STER_0372 3.1e-173 614.4 Bacilli manL 2.7.1.191 ko:K02793,ko:K02794 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 M00276 R02630 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.6.1 Bacteria 1TQJ4@1239,4H9Z8@91061,COG2893@1,COG2893@2,COG3444@1,COG3444@2 NA|NA|NA G pts system MIPOCGNA_00451 264199.stu0334 4.9e-139 500.4 Bacilli XK27_00940 1.2.1.70,3.5.1.9 ko:K02492,ko:K07130 ko00380,ko00630,ko00860,ko01100,ko01110,ko01120,map00380,map00630,map00860,map01100,map01110,map01120 M00038,M00121 R00988,R01959,R04109,R04911 RC00055,RC00149,RC00263,RC00323 ko00000,ko00001,ko00002,ko01000 Bacteria 1TRBQ@1239,4HCAB@91061,COG1878@1,COG1878@2 NA|NA|NA S Metal-dependent hydrolase MIPOCGNA_00452 322159.STER_0374 5.6e-152 543.5 Bacilli yitU 3.1.3.104 ko:K21064 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R07280 RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 1TREF@1239,4H9Y9@91061,COG0561@1,COG0561@2 NA|NA|NA S hydrolases of the HAD superfamily MIPOCGNA_00453 904306.HMPREF9192_0073 3e-241 840.9 Bacilli pbuO ko:K06901 ko00000,ko02000 2.A.1.40 Bacteria 1TQC6@1239,4HANG@91061,COG2252@1,COG2252@2 NA|NA|NA S permease MIPOCGNA_00454 264199.stu0337 1.4e-77 295.4 Bacilli ydiB GO:0002949,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.7.1.221,5.1.1.1 ko:K01775,ko:K06925,ko:K07102 ko00473,ko00520,ko01100,ko01502,map00473,map00520,map01100,map01502 R00401,R08968,R11024 RC00002,RC00078,RC00285 ko00000,ko00001,ko01000,ko01011,ko03016 Bacteria 1V6CV@1239,4HIIF@91061,COG0802@1,COG0802@2 NA|NA|NA M ATPase or kinase MIPOCGNA_00455 264199.stu0338 3.2e-92 344.4 Firmicutes XK27_05885 2.3.1.82 ko:K18816 br01600,ko00000,ko01000,ko01504 Bacteria 1VA2F@1239,COG1247@1,COG1247@2 NA|NA|NA M Acetyltransferase GNAT Family MIPOCGNA_00456 264199.stu0339 5.7e-217 760.0 Bacilli brpA Bacteria 1TR1B@1239,4HA09@91061,COG1316@1,COG1316@2 NA|NA|NA K Transcriptional MIPOCGNA_00457 264199.stu0340 3.9e-81 307.4 Bacilli rimP GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576 ko:K09748 ko00000,ko03009 Bacteria 1V6KT@1239,4HH88@91061,COG0779@1,COG0779@2 NA|NA|NA S Required for maturation of 30S ribosomal subunits MIPOCGNA_00458 322159.STER_0380 3.1e-212 744.2 Bacilli nusA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 ko:K02600,ko:K02945 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03009,ko03011,ko03021 Bacteria 1TPB3@1239,4HA7F@91061,COG0195@1,COG0195@2 NA|NA|NA K Participates in both transcription termination and antitermination MIPOCGNA_00459 264199.stu0342 3e-47 194.1 Bacilli ylxR ko:K02600,ko:K07742 ko00000,ko03009,ko03021 Bacteria 1VEJS@1239,4HKBY@91061,COG2740@1,COG2740@2 NA|NA|NA K Nucleic-acid-binding protein implicated in transcription termination MIPOCGNA_00460 264199.stu0343 1.4e-41 175.3 Bacilli ylxQ ko:K07590,ko:K07742 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1VEYG@1239,4HNY7@91061,COG1358@1,COG1358@2 NA|NA|NA J ribosomal protein MIPOCGNA_00461 264199.stu0344 0.0 1165.2 Bacilli infB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 ko:K02519 ko00000,ko03012,ko03029 Bacteria 1TPAI@1239,4HA8S@91061,COG0532@1,COG0532@2 NA|NA|NA J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex MIPOCGNA_00462 264199.stu0345 6.6e-57 226.5 Bacilli rbfA GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030490,GO:0033554,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071840,GO:0090304,GO:1901360 ko:K02834 ko00000,ko03009 Bacteria 1VA0P@1239,4HII1@91061,COG0858@1,COG0858@2 NA|NA|NA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA MIPOCGNA_00463 904306.HMPREF9192_0063 3.8e-73 280.8 Bacilli yvdD 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 Bacteria 1UKED@1239,4HGSU@91061,COG1611@1,COG1611@2 NA|NA|NA S Belongs to the LOG family MIPOCGNA_00465 264199.stu0348 5.9e-225 786.6 Bacilli femA 2.3.2.10,2.3.2.16,2.3.2.17,2.3.2.18 ko:K05363,ko:K11693,ko:K11694,ko:K11695,ko:K12554 ko00550,ko01100,map00550,map01100 R08776,R08777,R08778,R08779,R08780 RC00055,RC00064,RC00096 ko00000,ko00001,ko01000,ko01011 Bacteria 1UZIJ@1239,4HAQ3@91061,COG2348@1,COG2348@2 NA|NA|NA V protein involved in methicillin resistance MIPOCGNA_00466 264199.stu0349 7.9e-274 949.1 Bacilli murE 6.3.2.13,6.3.2.7 ko:K01928,ko:K05362 ko00300,ko00550,ko01100,map00300,map00550,map01100 R02786,R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 Bacteria 1TPQE@1239,4H9T1@91061,COG0769@1,COG0769@2 NA|NA|NA M to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan MIPOCGNA_00467 264199.stu0350 1e-282 978.8 Bacilli ytgP GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03328,ko:K06409 ko00000,ko02000 2.A.66.2,2.A.66.2.14 Bacteria 1TNYX@1239,4H9RY@91061,COG2244@1,COG2244@2 NA|NA|NA S Membrane protein involved in the export of O-antigen and teichoic acid MIPOCGNA_00468 1282665.H353_06423 2.3e-91 341.7 Bacilli pacL 3.6.3.8,3.6.3.9 ko:K01537,ko:K01539 ko04022,ko04024,ko04260,ko04261,ko04911,ko04918,ko04919,ko04925,ko04960,ko04961,ko04964,ko04970,ko04971,ko04972,ko04973,ko04974,ko04976,ko04978,map04022,map04024,map04260,map04261,map04911,map04918,map04919,map04925,map04960,map04961,map04964,map04970,map04971,map04972,map04973,map04974,map04976,map04978 ko00000,ko00001,ko01000,ko04147 3.A.3.1,3.A.3.2 Bacteria 1TPF5@1239,4HTQ4@91061,COG0474@1,COG0474@2 NA|NA|NA P cation transport ATPase MIPOCGNA_00469 264199.stu0352 1.1e-200 705.7 Bacilli metB GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0016740,GO:0016765,GO:0016829,GO:0016846 2.5.1.48,4.4.1.8 ko:K01739,ko:K01760 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04941,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00382,RC00420,RC00488,RC00710,RC01245,RC02303,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPC7@1239,4HAFQ@91061,COG0626@1,COG0626@2 NA|NA|NA E cystathionine MIPOCGNA_00470 264199.stu0353 2.8e-221 774.2 Bacilli malY 4.4.1.8 ko:K14155 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko01000,ko01007 Bacteria 1TP5G@1239,4H9PE@91061,COG1168@1,COG1168@2 NA|NA|NA E COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities MIPOCGNA_00471 1046629.Ssal_01837 8e-10 69.7 Bacilli sacB GO:0005575,GO:0005576 2.4.1.10,2.4.1.9,3.2.1.26 ko:K00692,ko:K01193,ko:K20811 ko00052,ko00500,ko01100,ko02020,map00052,map00500,map01100,map02020 R00801,R00802,R02410,R03635,R03921,R04194,R05140,R06088 RC00028,RC00077,RC00247 ko00000,ko00001,ko01000,ko01003 GH32,GH68 Bacteria 1TR8C@1239,4HBYU@91061,COG1621@1,COG1621@2 NA|NA|NA G Belongs to the glycosyl hydrolase 68 family MIPOCGNA_00472 264199.stu0355 4.4e-112 410.6 Bacilli upp GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.9 ko:K00761 ko00240,ko01100,map00240,map01100 R00966 RC00063 ko00000,ko00001,ko01000 iSB619.SA_RS11010 Bacteria 1TPMT@1239,4H9Y0@91061,COG0035@1,COG0035@2 NA|NA|NA F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate MIPOCGNA_00473 264199.stu0356 8.3e-105 386.3 Bacilli clpP GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0006355,GO:0006508,GO:0006515,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019538,GO:0030163,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042623,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051603,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 ko00000,ko00001,ko01000,ko01002 Bacteria 1TQ91@1239,4HA8J@91061,COG0740@1,COG0740@2 NA|NA|NA OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins MIPOCGNA_00474 264199.stu0357 1.3e-73 282.3 Bacilli ylbF Bacteria 1V3R6@1239,4HGYS@91061,COG3679@1,COG3679@2 NA|NA|NA S Belongs to the UPF0342 family MIPOCGNA_00475 264199.stu0358 7.1e-46 189.5 Bacilli ylbG Bacteria 1VF52@1239,4HNTH@91061,COG4471@1,COG4471@2 NA|NA|NA S UPF0298 protein MIPOCGNA_00476 264199.stu0359 9.1e-212 742.7 Bacilli livJ ko:K01999 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 1TPQ2@1239,4H9PI@91061,COG0683@1,COG0683@2 NA|NA|NA E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component MIPOCGNA_00477 264199.stu0360 1.9e-145 521.9 Bacilli livH ko:K01997 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 1TR24@1239,4HBFZ@91061,COG0559@1,COG0559@2 NA|NA|NA E Belongs to the binding-protein-dependent transport system permease family MIPOCGNA_00478 264199.stu0361 3.2e-138 498.0 Bacilli livM ko:K01995,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 1TPMZ@1239,4HDIU@91061,COG4177@1,COG4177@2 NA|NA|NA E Belongs to the binding-protein-dependent transport system permease family MIPOCGNA_00479 322159.STER_0401 9.6e-138 496.1 Bacilli livG ko:K01995,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 1TR0P@1239,4HASG@91061,COG0411@1,COG0411@2 NA|NA|NA E COG0411 ABC-type branched-chain amino acid transport systems, ATPase component MIPOCGNA_00480 1046629.Ssal_01828 4.8e-123 447.2 Bacilli livF ko:K01996 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 1TPW4@1239,4HABJ@91061,COG0410@1,COG0410@2 NA|NA|NA E COG0410 ABC-type branched-chain amino acid transport systems, ATPase component MIPOCGNA_00481 1046629.Ssal_01826 1e-39 169.1 Bacilli acuB ko:K04767 ko00000 Bacteria 1V4CD@1239,4HGX4@91061,COG0517@1,COG0517@2 NA|NA|NA S CBS domain MIPOCGNA_00482 264199.stu0365 9.3e-42 176.0 Bacteria acuB ko:K04767 ko00000 Bacteria COG0517@1,COG0517@2 NA|NA|NA S IMP dehydrogenase activity MIPOCGNA_00483 264199.stu0366 4.9e-168 597.0 Bacilli cysK GO:0000096,GO:0000097,GO:0000098,GO:0003674,GO:0003824,GO:0004122,GO:0004124,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006555,GO:0006563,GO:0006790,GO:0006807,GO:0008134,GO:0008144,GO:0008150,GO:0008152,GO:0008284,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009070,GO:0009087,GO:0009987,GO:0016043,GO:0016053,GO:0016054,GO:0016740,GO:0016765,GO:0016829,GO:0016835,GO:0016836,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0022607,GO:0030170,GO:0032991,GO:0032993,GO:0036094,GO:0042127,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043388,GO:0043436,GO:0043933,GO:0044085,GO:0044093,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046395,GO:0046983,GO:0048037,GO:0048518,GO:0048522,GO:0050662,GO:0050789,GO:0050794,GO:0051098,GO:0051099,GO:0051101,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051291,GO:0065003,GO:0065007,GO:0065009,GO:0070279,GO:0071704,GO:0071840,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1904796,GO:1904798,GO:2000677,GO:2000679 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP30@1239,4HAMU@91061,COG0031@1,COG0031@2 NA|NA|NA E Belongs to the cysteine synthase cystathionine beta- synthase family MIPOCGNA_00484 322159.STER_0405 6.3e-111 406.8 Bacilli yvyE 3.4.13.9 ko:K01271 ko00000,ko01000,ko01002 Bacteria 1V6MQ@1239,4HBIT@91061,COG1739@1,COG1739@2 NA|NA|NA S YigZ family MIPOCGNA_00485 322159.STER_0406 2e-252 877.9 Bacilli comFA GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 ko:K02240 M00429 ko00000,ko00002,ko02044 3.A.11.1 Bacteria 1TPZE@1239,4HB00@91061,COG4098@1,COG4098@2 NA|NA|NA L Superfamily II DNA RNA helicase required for DNA uptake (late competence protein) MIPOCGNA_00486 264199.stu0369 4.9e-122 443.7 Bacilli comFC ko:K02242 M00429 ko00000,ko00002,ko02044 Bacteria 1V73S@1239,4HJ6R@91061,COG1040@1,COG1040@2 NA|NA|NA S Competence protein MIPOCGNA_00487 264199.stu0370 2.4e-90 338.2 Bacilli hpf GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113 ko:K05808 ko00000,ko03009 Bacteria 1V1D5@1239,4HFX9@91061,COG1544@1,COG1544@2 NA|NA|NA J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase MIPOCGNA_00488 1116231.SMA_1383 5e-125 453.8 Bacilli Bacteria 1TYPK@1239,4HBUE@91061,COG0745@1,COG0745@2 NA|NA|NA T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain MIPOCGNA_00489 1116231.SMA_1384 9.7e-250 869.0 Bacilli Bacteria 1TS12@1239,4HEKK@91061,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor MIPOCGNA_00490 1116231.SMA_1385 0.0 1165.6 Bacilli Bacteria 1V2SB@1239,4HFEX@91061,COG3843@1,COG3843@2 NA|NA|NA U relaxase MIPOCGNA_00491 40041.SZO_17590 1.1e-57 229.2 Streptococcus dysgalactiae group Bacteria 1MA2M@119603,1U9FV@1239,2AN02@1,31CXB@2,4IJJG@91061 NA|NA|NA S Bacterial mobilisation protein (MobC) MIPOCGNA_00492 1123304.AQYA01000037_gene330 1.5e-56 225.3 Bacilli Bacteria 1W52Y@1239,2BWBR@1,2ZDFR@2,4I0XT@91061 NA|NA|NA MIPOCGNA_00493 482234.SCAZ3_06020 1.1e-220 772.3 Bacilli Bacteria 1UYYR@1239,4HHVE@91061,COG2865@1,COG2865@2 NA|NA|NA K Putative DNA-binding domain MIPOCGNA_00494 482234.SCAZ3_06015 1.3e-302 1045.0 Firmicutes Bacteria 1TSYK@1239,COG0210@1,COG0210@2 NA|NA|NA L Superfamily I DNA and RNA helicases MIPOCGNA_00495 663952.SDD27957_05240 0.0 1315.8 Bacilli ko:K07459 ko00000 Bacteria 1TWF2@1239,4HPZD@91061,COG3593@1,COG3593@2 NA|NA|NA L ATP-dependent endonuclease of the OLD family MIPOCGNA_00496 663952.SDD27957_05245 2.3e-131 474.9 Bacilli 2.7.1.176 ko:K07452,ko:K16214 ko00000,ko01000,ko02048 Bacteria 1V4WZ@1239,4HKUZ@91061,COG0542@1,COG0542@2 NA|NA|NA O Zeta toxin MIPOCGNA_00497 391295.SSU05_0937 1.6e-82 312.0 Streptococcus suis nprA ko:K18830,ko:K20480 ko02024,map02024 ko00000,ko00001,ko02048,ko03000 Bacteria 1VRZT@1239,1WSVV@1307,4HWSN@91061,COG1396@1,COG1396@2 NA|NA|NA K Cro/C1-type HTH DNA-binding domain MIPOCGNA_00498 1214217.ALNF01000037_gene351 1.5e-30 138.7 Streptococcus suis Bacteria 1U93B@1239,1WTNM@1307,2BV34@1,32QG3@2,4IJ43@91061 NA|NA|NA MIPOCGNA_00499 391295.SSU05_0939 1.5e-57 228.8 Streptococcus suis XK27_10880 Bacteria 1U91T@1239,1WTG8@1307,2AMA9@1,31C58@2,4IJ22@91061 NA|NA|NA MIPOCGNA_00500 391295.SSU05_0940 2.5e-17 94.4 Streptococcus suis XK27_10875 Bacteria 1U946@1239,1WTQH@1307,2BFJD@1,329DD@2,4IJ55@91061 NA|NA|NA MIPOCGNA_00501 996306.SSUR61_1130 3.8e-188 664.1 Streptococcus suis ko:K02316 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Bacteria 1TRTK@1239,1WT2U@1307,4HK3Y@91061,COG0358@1,COG0358@2 NA|NA|NA L Toprim-like MIPOCGNA_00502 663952.SDD27957_05275 7.1e-102 376.7 Bacteria XK27_10865 Bacteria 2DCG5@1,2ZE0K@2 NA|NA|NA MIPOCGNA_00503 1214166.ALLG01000025_gene1220 2.4e-36 157.9 Streptococcus suis Bacteria 1U94C@1239,1WTR0@1307,2AMFB@1,31CAV@2,4IJ5B@91061 NA|NA|NA MIPOCGNA_00504 996306.SSUR61_1133 6e-43 179.9 Streptococcus suis Bacteria 1U93N@1239,1WTP6@1307,29R24@1,30C38@2,4IJ4F@91061 NA|NA|NA MIPOCGNA_00505 391295.SSU05_0962 0.0 4196.4 Streptococcus suis XK27_00500 Bacteria 1TPQA@1239,1WSVK@1307,4HDHN@91061,COG0553@1,COG0553@2,COG0827@1,COG0827@2,COG4646@1,COG4646@2 NA|NA|NA L SNF2 family N-terminal domain MIPOCGNA_00506 996306.SSUR61_1139 1.6e-89 335.5 Streptococcus suis XK27_00505 Bacteria 1U906@1239,1WT7S@1307,2BQP9@1,32JJP@2,4IJ00@91061 NA|NA|NA MIPOCGNA_00507 996306.SSUR61_1140 5.1e-11 73.2 Streptococcus suis XK27_00510 Bacteria 1U94D@1239,1WTR2@1307,29R2E@1,30C3I@2,4IJ5D@91061 NA|NA|NA MIPOCGNA_00508 910313.HMPREF9320_1723 0.0 2798.5 Bacilli XK27_00515 Bacteria 1TSVF@1239,4HGKU@91061,COG3087@1,COG3087@2 NA|NA|NA D Glucan-binding protein C MIPOCGNA_00509 1282664.H354_02213 1.1e-94 352.8 Firmicutes Bacteria 1V17V@1239,COG4823@1,COG4823@2 NA|NA|NA V Abi-like protein MIPOCGNA_00510 1282664.H354_05061 4.4e-48 197.2 Firmicutes Bacteria 1V17V@1239,COG4823@1,COG4823@2 NA|NA|NA V Abi-like protein MIPOCGNA_00511 1214166.ALLG01000025_gene1228 0.0 1608.2 Streptococcus suis XK27_00530 Bacteria 1VPFZ@1239,1WSSZ@1307,4HFGV@91061,COG3942@1,COG3942@2 NA|NA|NA S CHAP domain MIPOCGNA_00512 996306.SSUR61_1147 0.0 1469.1 Streptococcus suis Bacteria 1TPDR@1239,1WSV1@1307,4HUB9@91061,COG3451@1,COG3451@2 NA|NA|NA U 'COG3451 Type IV secretory pathway, VirB4 components' MIPOCGNA_00513 1214217.ALNF01000064_gene2075 7.5e-61 239.6 Streptococcus suis XK27_00550 Bacteria 1U92M@1239,1WTK7@1307,2AMBF@1,31C6I@2,4IJ34@91061 NA|NA|NA S PrgI family protein MIPOCGNA_00514 910313.HMPREF9320_1729 9.7e-139 499.6 Bacilli Bacteria 1VY42@1239,2EFFF@1,33986@2,4HMPN@91061 NA|NA|NA MIPOCGNA_00515 1214166.ALLG01000025_gene1233 4.6e-33 146.7 Streptococcus suis XK27_00560 Bacteria 1W4XR@1239,1WTPF@1307,295KB@1,2ZSXU@2,4I17I@91061 NA|NA|NA MIPOCGNA_00516 1214217.ALNF01000064_gene2078 0.0 1185.6 Streptococcus suis traG ko:K03205 ko03070,map03070 M00333 ko00000,ko00001,ko00002,ko02044 3.A.7 Bacteria 1UAJF@1239,1WT6H@1307,4IPX4@91061,COG3505@1,COG3505@2 NA|NA|NA U Type IV secretory system Conjugative DNA transfer MIPOCGNA_00517 1214217.ALNF01000064_gene2079 9.3e-78 296.2 Streptococcus suis XK27_00570 Bacteria 1U8XR@1239,1WSKJ@1307,29QYR@1,30BZR@2,4IIWI@91061 NA|NA|NA MIPOCGNA_00518 996306.SSUR61_1153 8.3e-89 333.2 Streptococcus suis ypbD ko:K07052 ko00000 Bacteria 1W5XP@1239,1WSW7@1307,4I0RW@91061,COG1266@1,COG1266@2 NA|NA|NA S CAAX protease self-immunity MIPOCGNA_00519 996306.SSUR61_1154 1.5e-36 158.3 Streptococcus suis XK27_00580 Bacteria 1U945@1239,1WTQF@1307,2AMF1@1,31CAH@2,4IJ54@91061 NA|NA|NA MIPOCGNA_00520 1214217.ALNF01000064_gene2082 1.2e-64 252.3 Streptococcus suis XK27_00585 Bacteria 1U91V@1239,1WTGJ@1307,30C2H@2,4IJ24@91061,COG1393@1 NA|NA|NA P arsenate reductase (glutaredoxin) activity MIPOCGNA_00521 1214217.ALNF01000064_gene2083 6.5e-75 286.6 Streptococcus suis XK27_00590 Bacteria 1W4PT@1239,1WTD4@1307,2EV5A@1,33NK4@2,4IJ1G@91061 NA|NA|NA MIPOCGNA_00522 391295.SSU05_0979 7.4e-258 896.0 Streptococcus suis hpaIIM 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 Bacteria 1TPNE@1239,1WTDE@1307,4HB9C@91061,COG0270@1,COG0270@2 NA|NA|NA H C-5 cytosine-specific DNA methylase MIPOCGNA_00523 1214217.ALNF01000064_gene2086 1.9e-139 501.9 Streptococcus suis repA Bacteria 1VHQA@1239,1WSPT@1307,2DP1C@1,3304N@2,4HPY6@91061 NA|NA|NA S Replication initiator protein A (RepA) N-terminus MIPOCGNA_00524 1214217.ALNF01000064_gene2087 1.1e-20 105.1 Streptococcus suis Bacteria 1U94R@1239,1WTRT@1307,2AMGJ@1,31CC5@2,4IJ5U@91061 NA|NA|NA MIPOCGNA_00525 904306.HMPREF9192_1386 1.8e-248 864.8 Bacilli rumA GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070041,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.190 ko:K03215 ko00000,ko01000,ko03009 Bacteria 1TP4H@1239,4HA6M@91061,COG2265@1,COG2265@2 NA|NA|NA J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family MIPOCGNA_00526 322159.STER_0701 4.5e-97 360.5 Bacteria mip Bacteria COG2128@1,COG2128@2 NA|NA|NA S hydroperoxide reductase activity MIPOCGNA_00527 322159.STER_0700 7e-203 713.0 Bacilli Bacteria 1UYHK@1239,4HCT5@91061,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase MIPOCGNA_00528 1069533.Sinf_0933 4.3e-156 557.4 Bacteria ydiA ko:K03304,ko:K11041 ko05150,map05150 ko00000,ko00001,ko02000,ko02042 2.A.16,2.A.16.1 Bacteria COG1275@1,COG1275@2 NA|NA|NA P C4-dicarboxylate transporter malic acid transport protein MIPOCGNA_00529 322159.STER_0698 9e-238 829.3 Bacilli msrR Bacteria 1TSWQ@1239,4HE66@91061,COG1316@1,COG1316@2 NA|NA|NA K Transcriptional regulator MIPOCGNA_00530 264199.stu0647 2.3e-153 548.1 Bacilli pheA GO:0003674,GO:0003824,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 4.2.1.51 ko:K04518 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024 R00691,R01373 RC00360 ko00000,ko00001,ko00002,ko01000 iYO844.BSU27900 Bacteria 1TPDN@1239,4HA96@91061,COG0077@1,COG0077@2 NA|NA|NA E Prephenate dehydratase MIPOCGNA_00531 322159.STER_0696 1.7e-87 328.6 Bacilli aroK GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019438,GO:0019632,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615 1.1.1.25,2.7.1.71,4.2.1.10,4.2.3.4 ko:K00014,ko:K00891,ko:K03785,ko:K03786,ko:K13829,ko:K15546 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R02413,R03083,R03084 RC00002,RC00078,RC00206,RC00847,RC00848 ko00000,ko00001,ko00002,ko01000,ko03000 iAPECO1_1312.APECO1_1620,iECOK1_1307.ECOK1_0367,iECS88_1305.ECS88_0383,iUMN146_1321.UM146_15425,iUTI89_1310.UTI89_C0407,iYL1228.KPN_00332 Bacteria 1VA6Z@1239,4HKD6@91061,COG0703@1,COG0703@2 NA|NA|NA F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate MIPOCGNA_00532 322159.STER_0695 2.6e-236 824.3 Bacilli aroA GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 1.3.1.12,1.3.1.43,2.5.1.19 ko:K00210,ko:K00220,ko:K00800 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00022,M00025,M00040 R00732,R01728,R03460 RC00125,RC00350 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0345 Bacteria 1TPIH@1239,4HBHZ@91061,COG0128@1,COG0128@2 NA|NA|NA E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate MIPOCGNA_00533 322159.STER_0694 3e-173 614.4 Bacilli ldh 1.1.1.27 ko:K00016 ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922 R00703,R01000,R03104 RC00031,RC00044 ko00000,ko00001,ko01000,ko04147 Bacteria 1UXY2@1239,4HD1S@91061,COG0039@1,COG0039@2 NA|NA|NA C Belongs to the LDH MDH superfamily MIPOCGNA_00534 264199.stu0643 3.2e-53 214.2 Bacilli yheA Bacteria 1VASS@1239,4HPJM@91061,COG3679@1,COG3679@2 NA|NA|NA S Belongs to the UPF0342 family MIPOCGNA_00535 322159.STER_0692 6.3e-207 726.5 Bacilli tyrA GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.3.1.12,1.3.1.43 ko:K00210,ko:K00220,ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025,M00040 R00732,R01728 RC00125 ko00000,ko00001,ko00002,ko01000 iYO844.BSU22610 Bacteria 1TPXG@1239,4HBI4@91061,COG0287@1,COG0287@2 NA|NA|NA E prephenate dehydrogenase MIPOCGNA_00536 264199.stu0641 1.7e-218 765.0 Bacilli aroC GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016491,GO:0016651,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_0976,iNJ661.Rv2540c Bacteria 1TQ40@1239,4HA0H@91061,COG0082@1,COG0082@2 NA|NA|NA E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system MIPOCGNA_00537 322159.STER_0690 3.5e-202 710.7 Bacilli aroB 2.7.1.71,4.2.3.4 ko:K01735,ko:K13829 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPKZ@1239,4HAKN@91061,COG0337@1,COG0337@2 NA|NA|NA E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) MIPOCGNA_00538 322159.STER_0689 1.5e-160 572.0 Bacilli aroE GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQRY@1239,4HD4R@91061,COG0169@1,COG0169@2 NA|NA|NA E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) MIPOCGNA_00539 322159.STER_0688 8.6e-122 443.0 Bacilli aroD GO:0000166,GO:0003674,GO:0003824,GO:0003855,GO:0004764,GO:0005488,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25,4.2.1.10 ko:K03785,ko:K13832 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413,R03084 RC00206,RC00848 ko00000,ko00001,ko00002,ko01000 Bacteria 1VHVX@1239,4IPJP@91061,COG0710@1,COG0710@2 NA|NA|NA E Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate MIPOCGNA_00540 264199.stu0637 2.6e-219 767.7 Bacilli ywbD 2.1.1.191 ko:K06969 ko00000,ko01000,ko03009 Bacteria 1TRAJ@1239,4HAA1@91061,COG1092@1,COG1092@2 NA|NA|NA J Methyltransferase MIPOCGNA_00541 264199.stu0636 0.0 1387.9 Bacilli ltaS GO:0005575,GO:0005576 2.7.8.20 ko:K01138,ko:K19005 ko00561,ko01100,map00561,map01100 R05081,R10849 RC00017 ko00000,ko00001,ko01000 Bacteria 1TRMA@1239,4H9S0@91061,COG1368@1,COG1368@2 NA|NA|NA M Belongs to the LTA synthase family MIPOCGNA_00542 322159.STER_0685 1.3e-24 118.2 Firmicutes WQ51_00785 Bacteria 1W67C@1239,2FKS5@1,34CCP@2 NA|NA|NA MIPOCGNA_00543 1046629.Ssal_01521 8.2e-246 855.9 Bacilli eno GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005518,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0009986,GO:0016829,GO:0016835,GO:0016836,GO:0019899,GO:0030312,GO:0035375,GO:0043236,GO:0044424,GO:0044464,GO:0044877,GO:0050840,GO:0071944 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 Bacteria 1TP2S@1239,4HAKI@91061,COG0148@1,COG0148@2 NA|NA|NA G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis MIPOCGNA_00544 264199.stu0634 5.7e-77 293.5 Bacilli yueI Bacteria 1VFCV@1239,4HNNE@91061,COG5506@1,COG5506@2 NA|NA|NA S Protein of unknown function (DUF1694) MIPOCGNA_00545 322159.STER_0682 2.9e-207 727.6 Firmicutes glxK 2.7.1.165 ko:K00865 ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130 R08572 RC00002,RC00428 ko00000,ko00001,ko01000 Bacteria 1TPSI@1239,COG1929@1,COG1929@2 NA|NA|NA G Belongs to the glycerate kinase type-1 family MIPOCGNA_00546 264199.stu0632 2.9e-111 407.9 Firmicutes yyaQ Bacteria 1V4K7@1239,COG2315@1,COG2315@2 NA|NA|NA S YjbR MIPOCGNA_00547 904306.HMPREF9192_1362 5.2e-27 126.3 Bacilli yyaQ Bacteria 1V4K7@1239,4HP2K@91061,COG2315@1,COG2315@2 NA|NA|NA S YjbR MIPOCGNA_00548 322159.STER_0679 3.7e-182 644.0 Bacilli ccpA GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 ko:K02529 ko00000,ko03000 Bacteria 1TQ7K@1239,4H9NG@91061,COG1609@1,COG1609@2 NA|NA|NA K Catabolite control protein A MIPOCGNA_00549 264199.stu0629 2.7e-210 737.6 Bacilli pepQ 3.4.13.9 ko:K01271 ko00000,ko01000,ko01002 Bacteria 1TQ6R@1239,4HA5I@91061,COG0006@1,COG0006@2 NA|NA|NA E Belongs to the peptidase M24B family MIPOCGNA_00550 264199.stu0628 1.7e-63 248.4 Bacilli yugI 5.3.1.9 ko:K01810,ko:K02945,ko:K07570,ko:K07571,ko:K19142 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko03010,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map03010 M00001,M00004,M00114,M00178 R02739,R02740,R03321 RC00376,RC00563 br01610,ko00000,ko00001,ko00002,ko01000,ko02048,ko03011,ko04147 Bacteria 1VASQ@1239,4HKSW@91061,COG1098@1,COG1098@2 NA|NA|NA J RNA binding protein, contains ribosomal protein S1 domain MIPOCGNA_00551 322159.STER_0676 1.1e-275 955.3 Bacilli ppiB GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564 5.2.1.8 ko:K01802,ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 ko00000,ko00001,ko01000,ko03110,ko04147 Bacteria 1TRHW@1239,4H9V0@91061,COG0561@1,COG0561@2,COG0652@1,COG0652@2 NA|NA|NA G PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides MIPOCGNA_00552 264199.stu0626 1.1e-80 305.8 Bacilli smpB GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0070930,GO:0071704,GO:0097159,GO:1901363,GO:1901564 ko:K03664 ko00000 Bacteria 1V3IJ@1239,4HGZX@91061,COG0691@1,COG0691@2 NA|NA|NA O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA MIPOCGNA_00553 322159.STER_0674 0.0 1490.3 Bacilli rnr ko:K12573,ko:K12585 ko03018,map03018 M00391 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 Bacteria 1TQ1G@1239,4HBBH@91061,COG0557@1,COG0557@2 NA|NA|NA J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs MIPOCGNA_00554 322159.STER_0673 2.6e-33 147.5 Bacilli secG GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 Bacteria 1VEQR@1239,4HNKC@91061,COG1314@1,COG1314@2 NA|NA|NA U Preprotein translocase subunit SecG MIPOCGNA_00555 264199.stu0622 1.6e-219 768.5 Bacilli mdtG GO:0006810,GO:0006855,GO:0008150,GO:0015893,GO:0042221,GO:0042493,GO:0050896,GO:0051179,GO:0051234,GO:0055085 ko:K08161 ko00000,ko02000 2.A.1.2.20 Bacteria 1TRDJ@1239,4H9Q9@91061,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily MIPOCGNA_00556 264199.stu0621 1.3e-105 389.0 Bacilli coaE GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24,3.2.2.23,4.2.99.18 ko:K00859,ko:K08309,ko:K10563 ko00770,ko01100,ko03410,map00770,map01100,map03410 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01011,ko03400 GH23 iIT341.HP0831 Bacteria 1V6FS@1239,4HII3@91061,COG0237@1,COG0237@2 NA|NA|NA H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A MIPOCGNA_00557 264199.stu0620 1.9e-155 555.1 Bacilli fpg 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 1TPM9@1239,4H9Q7@91061,COG0266@1,COG0266@2 NA|NA|NA L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates MIPOCGNA_00558 264199.stu0619 1.3e-165 589.0 Bacilli era GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006275,GO:0008150,GO:0008156,GO:0009889,GO:0009890,GO:0009892,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051302,GO:0051781,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:2000104,GO:2000112,GO:2000113 ko:K03595,ko:K06883 ko00000,ko03009,ko03029 Bacteria 1TP3R@1239,4H9WF@91061,COG1159@1,COG1159@2 NA|NA|NA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism MIPOCGNA_00559 264199.stu0618 1.7e-64 251.9 Bacilli dgkA 2.7.1.107,2.7.1.66 ko:K00887,ko:K00901 ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231 R02240,R05626 RC00002,RC00017 ko00000,ko00001,ko01000 iAF987.Gmet_2369,iSB619.SA_RS07900 Bacteria 1VEGR@1239,4HNKN@91061,COG0818@1,COG0818@2 NA|NA|NA M Diacylglycerol kinase MIPOCGNA_00560 264199.stu0617 1.3e-87 328.9 Bacilli ybeY GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 2.6.99.2,3.5.4.5 ko:K01489,ko:K03474,ko:K03595,ko:K07042 ko00240,ko00750,ko00983,ko01100,map00240,map00750,map00983,map01100 M00124 R01878,R02485,R05838,R08221 RC00074,RC00514,RC01476 ko00000,ko00001,ko00002,ko01000,ko03009,ko03029 Bacteria 1V6BU@1239,4HIIE@91061,COG0319@1,COG0319@2 NA|NA|NA S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA MIPOCGNA_00561 904306.HMPREF9192_1347 3.6e-77 294.3 Bacilli licT ko:K02538,ko:K03488 ko00000,ko03000 Bacteria 1TT5A@1239,4HC5Y@91061,COG3711@1,COG3711@2 NA|NA|NA K antiterminator MIPOCGNA_00563 322159.STER_0663 2.2e-105 388.3 Bacilli recR GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 ko:K06187 ko03440,map03440 ko00000,ko00001,ko03400 Bacteria 1TR87@1239,4HAZR@91061,COG0353@1,COG0353@2 NA|NA|NA L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO MIPOCGNA_00564 322159.STER_0662 0.0 1240.3 Bacilli pbp2b 3.4.16.4 ko:K00687,ko:K05515,ko:K12553,ko:K21465 ko00550,ko01100,ko01501,map00550,map01100,map01501 ko00000,ko00001,ko01000,ko01011 Bacteria 1TQHY@1239,4HAFX@91061,COG0768@1,COG0768@2 NA|NA|NA M penicillin-binding protein MIPOCGNA_00565 322159.STER_0661 1.7e-148 531.9 Bacilli nnrD 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 ko00000,ko01000 Bacteria 1TNZE@1239,4HBZC@91061,COG0063@1,COG0063@2 NA|NA|NA H Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration MIPOCGNA_00566 322159.STER_0660 2.7e-157 561.2 Bacilli folD GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP1P@1239,4H9Q6@91061,COG0190@1,COG0190@2 NA|NA|NA F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate MIPOCGNA_00567 1046629.Ssal_01547 1.5e-23 114.8 Bacilli Bacteria 1V37Y@1239,4ITDD@91061,COG2267@1,COG2267@2 NA|NA|NA I Alpha/beta hydrolase family MIPOCGNA_00568 264199.stu0609 1.9e-33 147.9 Bacteria yugF GO:0003674,GO:0003824,GO:0016787 Bacteria COG2267@1,COG2267@2 NA|NA|NA I carboxylic ester hydrolase activity MIPOCGNA_00569 663952.SDD27957_07575 1.5e-07 61.2 Streptococcus dysgalactiae group Bacteria 1MA5P@119603,1TXF8@1239,2DJ8A@1,304YV@2,4I6DK@91061 NA|NA|NA MIPOCGNA_00570 264199.stu0608 0.0 1359.7 Bacilli feoB ko:K04759 ko00000,ko02000 9.A.8.1 Bacteria 1TP7E@1239,4HBCS@91061,COG0370@1,COG0370@2 NA|NA|NA P transporter of a GTP-driven Fe(2 ) uptake system MIPOCGNA_00571 264199.stu0607 1.2e-77 295.8 Bacilli feoA ko:K04758 ko00000,ko02000 Bacteria 1VEHC@1239,4HPFS@91061,COG1918@1,COG1918@2 NA|NA|NA P FeoA domain protein MIPOCGNA_00572 264199.stu0606 1.1e-130 472.6 Bacilli glnQ 3.6.3.21 ko:K02028 M00236 ko00000,ko00002,ko01000,ko02000 3.A.1.3 Bacteria 1TNYD@1239,4H9WY@91061,COG1126@1,COG1126@2 NA|NA|NA E abc transporter atp-binding protein MIPOCGNA_00573 264199.stu0605 3.2e-116 424.5 Bacilli WQ51_01820 ko:K02029,ko:K02030,ko:K10040,ko:K17073,ko:K17074 ko02010,map02010 M00228,M00236,M00589 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.20 Bacteria 1TPM3@1239,4IQKK@91061,COG0765@1,COG0765@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component MIPOCGNA_00574 264199.stu0604 1.3e-34 151.8 Bacilli ykuJ Bacteria 1VKD0@1239,4HRGC@91061,COG4703@1,COG4703@2 NA|NA|NA S protein conserved in bacteria MIPOCGNA_00575 264199.stu0603 3.1e-181 641.0 Bacilli argF GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPF2@1239,4H9X8@91061,COG0078@1,COG0078@2 NA|NA|NA E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline MIPOCGNA_00576 264199.stu0602 0.0 1308.5 Bacilli clpE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03697 ko00000,ko03110 Bacteria 1TPMU@1239,4HA0V@91061,COG0542@1,COG0542@2 NA|NA|NA O Belongs to the ClpA ClpB family MIPOCGNA_00577 322159.STER_0647 5.7e-85 320.1 Bacilli mutT 3.5.4.33,3.6.1.13,3.6.1.55 ko:K01515,ko:K03574,ko:K11991 ko00230,map00230 R01054,R10223 RC00002,RC00477 ko00000,ko00001,ko01000,ko03016,ko03400 Bacteria 1VH6Q@1239,4HQVJ@91061,COG0494@1,COG0494@2 NA|NA|NA L Belongs to the Nudix hydrolase family MIPOCGNA_00578 1046629.Ssal_01559 2.4e-47 194.5 Bacilli XK27_09445 Bacteria 1VFRS@1239,2EBZ8@1,335YI@2,4HNUK@91061 NA|NA|NA S Domain of unknown function (DUF1827) MIPOCGNA_00579 435842.HMPREF0848_00232 1.4e-54 218.8 Bacilli ko:K22230 ko00562,ko01120,map00562,map01120 R09954 RC00182 ko00000,ko00001,ko01000 Bacteria 1TQSS@1239,4HDXF@91061,COG0673@1,COG0673@2 NA|NA|NA S oxidoreductase MIPOCGNA_00580 435842.HMPREF0848_00232 3e-51 207.6 Bacilli ko:K22230 ko00562,ko01120,map00562,map01120 R09954 RC00182 ko00000,ko00001,ko01000 Bacteria 1TQSS@1239,4HDXF@91061,COG0673@1,COG0673@2 NA|NA|NA S oxidoreductase MIPOCGNA_00581 322159.STER_0644 9.8e-233 812.4 Bacilli murN 2.3.2.10,2.3.2.16 ko:K05363,ko:K11693,ko:K12554 ko00550,ko01100,map00550,map01100 R08776,R08779,R08780 RC00055,RC00064,RC00096 ko00000,ko00001,ko01000,ko01011 Bacteria 1V181@1239,4HEVU@91061,COG2348@1,COG2348@2 NA|NA|NA V FemAB family MIPOCGNA_00582 1046629.Ssal_01562 6.1e-70 270.4 Bacteria Bacteria COG0398@1,COG0398@2 NA|NA|NA M Pfam SNARE associated Golgi protein MIPOCGNA_00583 904306.HMPREF9192_1327 2.6e-101 374.8 Bacilli Bacteria 1VGN9@1239,2DMIQ@1,32RV1@2,4I0DZ@91061 NA|NA|NA S Domain of Unknown Function with PDB structure (DUF3862) MIPOCGNA_00586 264199.stu0592 1.3e-202 712.2 Bacilli rpsA 1.17.7.4 ko:K02945,ko:K03527 ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010 M00096,M00178 R05884,R08210 RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 Bacteria 1TQ9N@1239,4H9PX@91061,COG0539@1,COG0539@2 NA|NA|NA J ribosomal protein S1 MIPOCGNA_00589 1035187.HMPREF9959_0525 1.1e-15 89.0 Streptococcus mitis Bacteria 1U4J6@1239,29N96@1,2TPZ6@28037,30971@2,4IEAX@91061 NA|NA|NA S Protein of unknown function (DUF2969) MIPOCGNA_00590 264199.stu0590 3.4e-199 700.7 Bacilli ilvE 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 1TQQI@1239,4HASX@91061,COG0115@1,COG0115@2 NA|NA|NA E Aminotransferase MIPOCGNA_00591 264199.stu0589 0.0 1557.7 Bacilli parC GO:0005575,GO:0005622,GO:0005623,GO:0009330,GO:0032991,GO:0044424,GO:0044464 5.99.1.3 ko:K02469,ko:K02621 ko00000,ko01000,ko02048,ko03032,ko03036,ko03400 Bacteria 1TRE7@1239,4HAQB@91061,COG0188@1,COG0188@2 NA|NA|NA L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule MIPOCGNA_00592 322159.STER_0633 0.0 1228.8 Bacilli parE GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0034335,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 5.99.1.3 ko:K02470,ko:K02622 ko00000,ko01000,ko02048,ko03032,ko03036,ko03400 Bacteria 1TQCF@1239,4H9UC@91061,COG0187@1,COG0187@2 NA|NA|NA L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule MIPOCGNA_00593 322159.STER_0632 1.6e-101 375.6 Bacilli plsY GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.3.1.15,3.5.1.104 ko:K08591,ko:K22278 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 1VA3J@1239,4HC55@91061,COG0344@1,COG0344@2 NA|NA|NA I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP MIPOCGNA_00594 759913.SDSE_1678 8.3e-15 86.7 Streptococcus dysgalactiae group Bacteria 1M9TG@119603,1TXCP@1239,2DJ7H@1,304X7@2,4I6AH@91061 NA|NA|NA L Helix-hairpin-helix DNA-binding motif class 1 MIPOCGNA_00595 1035184.HMPREF1042_0385 1.4e-29 135.2 Streptococcus anginosus group Bacteria 1VYRT@1239,2BXCI@1,346RD@2,42DR8@671232,4HYPP@91061 NA|NA|NA S Domain of unknown function (DUF1912) MIPOCGNA_00596 264199.stu0584 3.1e-178 630.9 Bacilli mmuM GO:0003674,GO:0003824,GO:0005488,GO:0006575,GO:0006790,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008270,GO:0008757,GO:0008898,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0033477,GO:0033554,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:1901564 1.5.1.20,2.1.1.10 ko:K00297,ko:K00547 ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523 M00377 R00650,R01224,R07168 RC00003,RC00035,RC00081 ko00000,ko00001,ko00002,ko01000 Bacteria 1UHQ5@1239,4HAS6@91061,COG2040@1,COG2040@2 NA|NA|NA H Homocysteine MIPOCGNA_00597 264199.stu0583 1.3e-249 868.6 Bacilli mmuP GO:0000096,GO:0000097,GO:0000100,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0006810,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0015806,GO:0016020,GO:0016053,GO:0019752,GO:0022857,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0072337,GO:0072348,GO:0072349,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901682 ko:K02205,ko:K03293,ko:K16235,ko:K16236 ko00000,ko02000 2.A.3.1,2.A.3.1.10 Bacteria 1UHNR@1239,4HUT7@91061,COG0833@1,COG0833@2 NA|NA|NA E amino acid MIPOCGNA_00598 264199.stu0582 3e-110 404.4 Bacilli engB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:0097367,GO:1901265,GO:1901363 ko:K03978 ko00000,ko03036 Bacteria 1TSPW@1239,4HBXZ@91061,COG0218@1,COG0218@2 NA|NA|NA D Necessary for normal cell division and for the maintenance of normal septation MIPOCGNA_00599 322159.STER_0625 3.7e-224 783.9 Bacilli clpX GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030312,GO:0030554,GO:0031333,GO:0031597,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0043335,GO:0044087,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0051704,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 ko:K03544 ko04112,map04112 ko00000,ko00001,ko03110 Bacteria 1TQ00@1239,4H9U4@91061,COG1219@1,COG1219@2 NA|NA|NA O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP MIPOCGNA_00600 435842.HMPREF0848_00215 9.7e-22 108.6 Bacilli Bacteria 1W5G0@1239,2DFKW@1,2ZS8U@2,4HZFD@91061 NA|NA|NA MIPOCGNA_00601 322159.STER_0623 5.3e-92 343.6 Bacilli folA 1.5.1.3,1.5.1.47,2.1.1.45,3.5.4.12 ko:K00287,ko:K00560,ko:K01493,ko:K05896,ko:K17364 ko00240,ko00670,ko00790,ko01100,ko01523,map00240,map00670,map00790,map01100,map01523 M00053,M00126,M00429,M00840 R00936,R00937,R00939,R00940,R01663,R02101,R02235,R02236,R03388,R11765 RC00074,RC00109,RC00110,RC00158,RC00219,RC00332,RC01584 ko00000,ko00001,ko00002,ko01000,ko02044,ko03036 Bacteria 1VB80@1239,4HIGJ@91061,COG0262@1,COG0262@2 NA|NA|NA H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis MIPOCGNA_00602 322159.STER_0622 1.9e-166 591.7 Bacilli thyA 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 Bacteria 1TSIR@1239,4HI1C@91061,COG0207@1,COG0207@2 NA|NA|NA F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis MIPOCGNA_00603 264199.stu0577 2.9e-218 764.2 Bacilli mvaS 2.3.3.10 ko:K01641 ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130 M00088,M00095 R01978 RC00004,RC00503 ko00000,ko00001,ko00002,ko01000 Bacteria 1TR4K@1239,4HA67@91061,COG3425@1,COG3425@2 NA|NA|NA I synthase MIPOCGNA_00604 264199.stu0576 1.6e-230 805.1 Bacilli mvaA 1.1.1.34,1.1.1.88,2.3.1.9 ko:K00021,ko:K00054,ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,ko04152,ko04976,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020,map04152,map04976 M00088,M00095,M00373,M00374,M00375 R00238,R01177,R02081,R02082 RC00004,RC00326,RC00644 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1TPNY@1239,4HBQ3@91061,COG1257@1,COG1257@2 NA|NA|NA C Belongs to the HMG-CoA reductase family MIPOCGNA_00605 264199.stu0575 4.7e-120 437.2 Bacilli yqfA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K11068 ko00000,ko02042 Bacteria 1TTA5@1239,4HDYT@91061,COG1272@1,COG1272@2 NA|NA|NA K protein, Hemolysin III MIPOCGNA_00606 904306.HMPREF9192_1302 1.2e-22 111.7 Bacilli Bacteria 1VFZ3@1239,2DQ82@1,3357U@2,4HNXV@91061 NA|NA|NA S Protein of unknown function (DUF3114) MIPOCGNA_00607 264199.stu0574 9.8e-163 579.3 Bacilli Bacteria 1VFZ3@1239,2DQ82@1,3357U@2,4HNXV@91061 NA|NA|NA S Protein of unknown function (DUF3114) MIPOCGNA_00608 264199.stu0573 2.2e-168 598.2 Bacilli Bacteria 1V202@1239,4HJ0U@91061,COG0596@1,COG0596@2 NA|NA|NA S hydrolases or acyltransferases (alpha beta hydrolase superfamily) MIPOCGNA_00609 264199.stu0572 0.0 1319.7 Bacilli thrS GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1TP78@1239,4HABZ@91061,COG0441@1,COG0441@2 NA|NA|NA J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) MIPOCGNA_00610 889204.HMPREF9423_1244 3.5e-49 200.7 Bacilli XK27_13030 Bacteria 1VBNS@1239,2DMJF@1,32RYX@2,4HMXU@91061 NA|NA|NA MIPOCGNA_00611 264199.stu0570 3.4e-247 860.5 Bacilli mgs GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006629,GO:0006643,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046872,GO:0071704,GO:1901576 2.4.1.337 ko:K19002 ko00561,ko01100,map00561,map01100 R10850 RC00005,RC00059 ko00000,ko00001,ko01000,ko01003 GT4 Bacteria 1TPTA@1239,4HA41@91061,COG0438@1,COG0438@2 NA|NA|NA M Glycosyltransferase, group 1 family protein MIPOCGNA_00612 322159.STER_0610 7.6e-191 672.9 Bacilli dgs 2.4.1.208 ko:K13677 ko00561,ko01100,map00561,map01100 R05164 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003 GT4 Bacteria 1TPSS@1239,4HBKA@91061,COG0438@1,COG0438@2 NA|NA|NA M Glycosyltransferase, group 1 family protein MIPOCGNA_00613 435842.HMPREF0848_00198 2.5e-08 65.5 Firmicutes Bacteria 1UXB4@1239,COG4932@1,COG4932@2 NA|NA|NA M Pilin isopeptide linkage domain protein MIPOCGNA_00614 1046629.Ssal_01596 1.8e-49 202.2 Bacteria ko:K02460 ko03070,ko05111,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02044 3.A.15 Bacteria COG3156@1,COG3156@2,COG4932@1,COG4932@2 NA|NA|NA U protein secretion MIPOCGNA_00615 1046629.Ssal_01596 3e-29 134.4 Bacteria ko:K02460 ko03070,ko05111,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02044 3.A.15 Bacteria COG3156@1,COG3156@2,COG4932@1,COG4932@2 NA|NA|NA U protein secretion MIPOCGNA_00617 264199.stu0566 2e-118 431.8 Bacilli mtnN 3.2.2.9 ko:K01243 ko00270,ko01100,ko01230,map00270,map01100,map01230 M00034,M00609 R00194,R01401 RC00063,RC00318 ko00000,ko00001,ko00002,ko01000 Bacteria 1U7WK@1239,4HB8K@91061,COG0775@1,COG0775@2 NA|NA|NA E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively MIPOCGNA_00618 322159.STER_0605 2.5e-21 107.8 Bacteria Bacteria 2DC3Q@1,2ZCSA@2 NA|NA|NA MIPOCGNA_00619 322159.STER_0604 1e-96 359.4 Bacilli nudF 3.6.1.13 ko:K01515 ko00230,map00230 R01054 RC00002 ko00000,ko00001,ko01000 iHN637.CLJU_RS05505,iSB619.SA_RS07540,iYO844.BSU23610 Bacteria 1V6F5@1239,4HII9@91061,COG0494@1,COG0494@2 NA|NA|NA L AdP-ribose pyrophosphatase MIPOCGNA_00620 322159.STER_0603 1.8e-251 874.8 Bacilli glmU GO:0000270,GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006629,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009252,GO:0009273,GO:0009987,GO:0016051,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030203,GO:0030260,GO:0033692,GO:0034637,GO:0034645,GO:0035635,GO:0040007,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903509 2.3.1.157,2.7.7.23 ko:K04042,ko:K11528 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP88@1239,4H9V5@91061,COG1207@1,COG1207@2 NA|NA|NA M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain MIPOCGNA_00621 1046629.Ssal_01605 6.2e-185 653.3 Bacilli fni 1.1.1.88,5.3.3.2 ko:K00054,ko:K01823 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00095,M00096,M00364,M00365,M00366,M00367 R01123,R02081 RC00004,RC00455,RC00644 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQZ3@1239,4HAMV@91061,COG1304@1,COG1304@2 NA|NA|NA C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) MIPOCGNA_00622 322159.STER_0600 3.1e-176 624.4 Bacilli mvaK2 2.7.1.36,2.7.1.43,2.7.4.2 ko:K00869,ko:K00938,ko:K16190 ko00040,ko00053,ko00520,ko00900,ko01100,ko01110,ko01130,ko04146,map00040,map00053,map00520,map00900,map01100,map01110,map01130,map04146 M00014,M00095 R01476,R02245,R03245 RC00002,RC00017,RC00078 ko00000,ko00001,ko00002,ko01000 Bacteria 1VXNZ@1239,4IRFS@91061,COG1577@1,COG1577@2 NA|NA|NA I GHMP kinases N terminal domain MIPOCGNA_00623 264199.stu0560 1.1e-170 605.9 Bacilli mvaD 4.1.1.33 ko:K01597 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00095 R01121 RC00453 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQXR@1239,4HAM6@91061,COG3407@1,COG3407@2 NA|NA|NA I diphosphomevalonate decarboxylase MIPOCGNA_00624 264199.stu0559 1.6e-136 492.3 Bacilli mvk 1.1.1.88,2.3.3.10,2.7.1.36 ko:K00054,ko:K00869,ko:K01641 ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,ko04146,map00072,map00280,map00650,map00900,map01100,map01110,map01130,map04146 M00088,M00095 R01978,R02081,R02245 RC00002,RC00004,RC00017,RC00503,RC00644 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPVW@1239,4IRCB@91061,COG1577@1,COG1577@2 NA|NA|NA I mevalonate kinase MIPOCGNA_00625 264199.stu0558 8.8e-104 382.9 Bacilli GBS0088 ko:K09962 ko00000 Bacteria 1V1YD@1239,4HGK6@91061,COG3575@1,COG3575@2 NA|NA|NA J protein conserved in bacteria MIPOCGNA_00626 264199.stu0557 2.2e-246 857.8 Bacilli merA GO:0000302,GO:0000305,GO:0001101,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016491,GO:0016667,GO:0019725,GO:0042221,GO:0042592,GO:0044424,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901530,GO:1901700,GO:1990748 1.16.1.1 ko:K00520,ko:K21739 ko00000,ko01000 Bacteria 1TP1W@1239,4HBZF@91061,COG1249@1,COG1249@2 NA|NA|NA C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family MIPOCGNA_00627 435842.HMPREF0848_00185 3.8e-46 190.7 Bacilli ald GO:0000286,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009653,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0019752,GO:0030154,GO:0030435,GO:0032502,GO:0043436,GO:0043934,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048646,GO:0048856,GO:0048869,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 R00396 RC00008 ko00000,ko00001,ko01000 iAF987.Gmet_1099 Bacteria 1TNZ5@1239,4HABX@91061,COG0686@1,COG0686@2 NA|NA|NA C Belongs to the AlaDH PNT family MIPOCGNA_00628 264199.stu0555 3.4e-17 93.2 Bacteria ald GO:0000286,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009653,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0019752,GO:0030154,GO:0030435,GO:0032502,GO:0043436,GO:0043934,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048646,GO:0048856,GO:0048869,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 R00396 RC00008 ko00000,ko00001,ko01000 iAF987.Gmet_1099 Bacteria COG0686@1,COG0686@2 NA|NA|NA E alanine dehydrogenase activity MIPOCGNA_00629 322159.STER_0594 1.5e-219 768.5 Bacilli hipO 3.5.1.47 ko:K01436,ko:K05823,ko:K21613 ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230 M00525 R02733 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000,ko01002 Bacteria 1TPD7@1239,4H9WQ@91061,COG1473@1,COG1473@2 NA|NA|NA E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase MIPOCGNA_00630 264199.stu0553 7.4e-132 476.5 Bacilli rsuA 5.4.99.19,5.4.99.22 ko:K06178,ko:K06183 ko00000,ko01000,ko03009 Bacteria 1TQZ2@1239,4H9VU@91061,COG1187@1,COG1187@2 NA|NA|NA J Belongs to the pseudouridine synthase RsuA family MIPOCGNA_00631 264199.stu0552 5.6e-113 413.7 Bacilli Bacteria 1V6KW@1239,4IPIC@91061,COG1814@1,COG1814@2 NA|NA|NA S VIT family MIPOCGNA_00632 322159.STER_0591 2.8e-145 521.2 Bacilli deoD_1 2.4.2.3 ko:K00757 ko00240,ko00983,ko01100,map00240,map00983,map01100 R01876,R02484,R08229 RC00063 ko00000,ko00001,ko01000 Bacteria 1V6T2@1239,4HCSE@91061,COG2820@1,COG2820@2 NA|NA|NA F Phosphorylase superfamily MIPOCGNA_00633 655813.HMPREF8579_1629 7.4e-22 110.5 Streptococcus oralis Bacteria 1TWW2@1239,1WPHP@1303,29QF9@1,30BEN@2,4I5QM@91061 NA|NA|NA MIPOCGNA_00634 1046629.Ssal_01621 1.6e-28 131.3 Bacilli XK27_00085 ko:K07729 ko00000,ko03000 Bacteria 1VERT@1239,4HNID@91061,COG1476@1,COG1476@2 NA|NA|NA K Transcriptional MIPOCGNA_00635 1046629.Ssal_01622 6.5e-195 686.4 Bacilli yceA ko:K07146 ko00000 Bacteria 1TRG7@1239,4HA0J@91061,COG1054@1,COG1054@2 NA|NA|NA S Belongs to the UPF0176 family MIPOCGNA_00636 264199.stu0547 5.4e-122 443.7 Bacilli sagI ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1USMY@1239,4HC3J@91061,COG1511@1,COG1511@2 NA|NA|NA S ABC-2 type transporter MIPOCGNA_00637 322159.STER_0586 4.8e-168 597.0 Bacilli ko:K01990,ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1UZK5@1239,4HB2Q@91061,COG1131@1,COG1131@2 NA|NA|NA V ABC transporter MIPOCGNA_00638 264199.stu0545 1.7e-107 395.2 Bacilli 2.7.7.73,2.7.7.80 ko:K03148,ko:K21029 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07459 RC00043 ko00000,ko00001,ko01000 Bacteria 1TQ3U@1239,4HBGP@91061,COG0476@1,COG0476@2 NA|NA|NA H Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 MIPOCGNA_00639 264199.stu0545 9.7e-83 312.8 Bacilli 2.7.7.73,2.7.7.80 ko:K03148,ko:K21029 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07459 RC00043 ko00000,ko00001,ko01000 Bacteria 1TQ3U@1239,4HBGP@91061,COG0476@1,COG0476@2 NA|NA|NA H Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 MIPOCGNA_00640 322159.STER_0583 2.1e-131 474.9 Bacilli rr02 Bacteria 1TXDF@1239,4HDA7@91061,COG3279@1,COG3279@2 NA|NA|NA KT response regulator MIPOCGNA_00641 322159.STER_0582 1.3e-214 752.3 Bacilli 2.7.13.3 ko:K07706 ko02020,ko02024,map02020,map02024 M00495 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1UDI2@1239,4HF65@91061,COG3290@1,COG3290@2 NA|NA|NA T signal transduction protein with a C-terminal ATPase domain MIPOCGNA_00642 1046629.Ssal_01624 2.9e-120 438.0 Bacilli nagB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006040,GO:0008150,GO:0008152,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901135 3.1.1.31,3.5.99.6 ko:K01057,ko:K02564 ko00030,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00520,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R00765,R02035 RC00163,RC00537 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP10@1239,4HAG4@91061,COG0363@1,COG0363@2 NA|NA|NA G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion MIPOCGNA_00643 322159.STER_0580 4.6e-199 700.3 Bacilli queA GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 ko:K07568 ko00000,ko01000,ko03016 Bacteria 1TPKD@1239,4H9PT@91061,COG0809@1,COG0809@2 NA|NA|NA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) MIPOCGNA_00644 322159.STER_0579 0.0 1135.6 Bacilli lmrA ko:K06147,ko:K18888 ko02010,map02010 M00706 ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 1TP0B@1239,4HA3S@91061,COG1132@1,COG1132@2 NA|NA|NA V abc transporter atp-binding protein MIPOCGNA_00645 322159.STER_0578 0.0 1098.6 Bacilli mdlB ko:K06147,ko:K06148,ko:K18887 ko02010,map02010 M00706 ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 1TP0B@1239,4H9SC@91061,COG1132@1,COG1132@2 NA|NA|NA V abc transporter atp-binding protein MIPOCGNA_00647 322159.STER_0576 0.0 1219.1 Firmicutes Bacteria 1V15F@1239,COG3266@1,COG3266@2 NA|NA|NA M the current gene model (or a revised gene model) may contain a MIPOCGNA_00648 904306.HMPREF9192_0446 1.9e-49 201.8 Bacilli ko:K14194,ko:K14195 ko05150,map05150 ko00000,ko00001 Bacteria 1UYRE@1239,4ISZF@91061,COG2373@1,COG2373@2,COG4932@1,COG4932@2 NA|NA|NA M YSIRK type signal peptide MIPOCGNA_00649 322159.STER_0574 3e-92 345.1 Bacteria Bacteria 2DVN5@1,33WG3@2 NA|NA|NA S MucBP domain MIPOCGNA_00652 322159.STER_1347 2.8e-164 584.7 Bacilli hrtB ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 1VRMK@1239,4HTA7@91061,COG0577@1,COG0577@2 NA|NA|NA V MacB-like periplasmic core domain MIPOCGNA_00653 322159.STER_1348 1.3e-117 429.1 Bacilli devA 3.6.3.25 ko:K02003,ko:K06020,ko:K09810 ko02010,map02010 M00255,M00258 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.125 Bacteria 1TQP5@1239,4HBXK@91061,COG1136@1,COG1136@2 NA|NA|NA V abc transporter atp-binding protein MIPOCGNA_00654 1410626.JHXB01000031_gene1709 1.6e-18 98.2 unclassified Lachnospiraceae Bacteria 1TRUP@1239,24AJD@186801,27KEC@186928,COG2801@1,COG2801@2 NA|NA|NA L Integrase core domain MIPOCGNA_00655 322159.STER_0842 1.2e-112 412.5 Firmicutes ko:K07485 ko00000 Bacteria 1TQ93@1239,COG3464@1,COG3464@2 NA|NA|NA L Transposase MIPOCGNA_00656 1214184.ALKY01000014_gene286 6.5e-108 396.7 Streptococcus suis Bacteria 1TQ93@1239,1WT4S@1307,4HJK9@91061,COG3464@1,COG3464@2 NA|NA|NA L Transposase MIPOCGNA_00657 1449342.JQMR01000001_gene1853 2.9e-48 198.4 Bacteria Bacteria COG3247@1,COG3247@2 NA|NA|NA U response to pH MIPOCGNA_00658 1229783.C273_11852 8.5e-22 110.2 Staphylococcaceae ko:K07485 ko00000 Bacteria 1TQ93@1239,4GYPD@90964,4HC0Q@91061,COG3464@1,COG3464@2 NA|NA|NA L Transposase for ISSha1 MIPOCGNA_00659 322159.STER_0842 1.2e-112 412.5 Firmicutes ko:K07485 ko00000 Bacteria 1TQ93@1239,COG3464@1,COG3464@2 NA|NA|NA L Transposase MIPOCGNA_00660 322159.STER_0842 7.9e-64 249.6 Firmicutes ko:K07485 ko00000 Bacteria 1TQ93@1239,COG3464@1,COG3464@2 NA|NA|NA L Transposase MIPOCGNA_00661 322159.STER_0568 3e-52 211.1 Bacilli rplL ko:K02935 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V6EI@1239,4HIGQ@91061,COG0222@1,COG0222@2 NA|NA|NA J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation MIPOCGNA_00662 435842.HMPREF0848_00164 5.6e-78 297.0 Bacilli rplJ GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0017148,GO:0019222,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02864,ko:K02935 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V3JJ@1239,4HH0N@91061,COG0244@1,COG0244@2 NA|NA|NA J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors MIPOCGNA_00663 1054460.SPPN_04745 0.0 1717.6 Bacilli res 3.1.21.5 ko:K01156 ko00000,ko01000,ko02048 Bacteria 1TPRR@1239,4HBNH@91061,COG3587@1,COG3587@2 NA|NA|NA L restriction endonuclease MIPOCGNA_00665 1035187.HMPREF9959_0154 1.4e-71 276.2 Streptococcus mitis Bacteria 1U4QJ@1239,2DIR8@1,2TQ65@28037,303Z4@2,4IEGD@91061 NA|NA|NA S Domain of unknown function (DUF4391) MIPOCGNA_00666 365659.smi_1251 0.0 1795.8 Streptococcus mitis Bacteria 1TQH0@1239,2TQ5W@28037,4HAQK@91061,COG0553@1,COG0553@2 NA|NA|NA L SNF2 family N-terminal domain MIPOCGNA_00667 435842.HMPREF0848_00163 7.1e-212 743.0 Bacilli ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TPUU@1239,4HF9U@91061,COG0577@1,COG0577@2 NA|NA|NA V permease protein MIPOCGNA_00668 1046629.Ssal_01636 3.7e-120 437.6 Bacilli macB ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TPBJ@1239,4HBMF@91061,COG1136@1,COG1136@2 NA|NA|NA V ABC transporter, ATP-binding protein MIPOCGNA_00669 435842.HMPREF0848_00161 4.2e-175 620.9 Bacilli acrA GO:0003674,GO:0005488,GO:0005515,GO:0042802 ko:K02005 ko00000 Bacteria 1VBR9@1239,4HG5X@91061,COG0845@1,COG0845@2 NA|NA|NA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family MIPOCGNA_00670 1046629.Ssal_01638 2.5e-122 444.9 Bacilli 2.1.1.223 ko:K15460 ko00000,ko01000,ko03016 Bacteria 1UJ4P@1239,4IT17@91061,COG4123@1,COG4123@2 NA|NA|NA S Putative SAM-dependent methyltransferase MIPOCGNA_00671 264199.stu0527 0.0 2064.3 Bacilli carB GO:0000050,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPID@1239,4HAEY@91061,COG0458@1,COG0458@2 NA|NA|NA F carbamoyl-phosphate synthetase ammonia chain MIPOCGNA_00672 322159.STER_0558 2.1e-210 738.0 Bacilli carA GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01955,ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1383,iYO844.BSU15510 Bacteria 1TQ8N@1239,4H9Z0@91061,COG0505@1,COG0505@2 NA|NA|NA F carbamoyl-phosphate synthetase glutamine chain MIPOCGNA_00673 264199.stu0525 1e-173 615.9 Bacilli pyrB GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 ko:K00608,ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 iYO844.BSU15490 Bacteria 1TQ96@1239,4H9M6@91061,COG0540@1,COG0540@2 NA|NA|NA F Belongs to the ATCase OTCase family MIPOCGNA_00674 322159.STER_0556 1.9e-226 791.6 Bacilli pyrP ko:K02824 ko00000,ko02000 2.A.40.1.1,2.A.40.1.2 iLJ478.TM0819 Bacteria 1TQKX@1239,4HAEU@91061,COG2233@1,COG2233@2 NA|NA|NA F uracil Permease MIPOCGNA_00675 264199.stu0523 1.1e-87 329.3 Bacilli pyrR 2.4.2.9 ko:K02825 ko00240,ko01100,map00240,map01100 R00966 RC00063 ko00000,ko00001,ko01000,ko03000 Bacteria 1V3GV@1239,4HGYE@91061,COG2065@1,COG2065@2 NA|NA|NA F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant MIPOCGNA_00676 264199.stu0522 8.5e-162 576.2 Bacilli rluD GO:0000027,GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022607,GO:0022613,GO:0022618,GO:0031118,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 ko:K06180 ko00000,ko01000,ko03009 iE2348C_1286.E2348C_2868,iECED1_1282.ECED1_3035,iECSF_1327.ECSF_2432 Bacteria 1TPCM@1239,4HBG2@91061,COG0564@1,COG0564@2 NA|NA|NA J Responsible for synthesis of pseudouridine from uracil MIPOCGNA_00677 264199.stu0521 2.6e-77 294.7 Bacilli lspA 3.4.23.36 ko:K03101 ko03060,map03060 ko00000,ko00001,ko01000,ko01002 Bacteria 1VA9R@1239,4HIR4@91061,COG0597@1,COG0597@2 NA|NA|NA MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins MIPOCGNA_00678 904306.HMPREF9192_0429 1.5e-166 592.0 Bacilli fhuR Bacteria 1V53I@1239,4HIEU@91061,COG0583@1,COG0583@2 NA|NA|NA K transcriptional regulator (lysR family) MIPOCGNA_00683 322159.STER_0545 4.1e-141 507.3 Bacteria ppiA 5.2.1.8 ko:K01802,ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 ko00000,ko00001,ko01000,ko03110,ko04147 Bacteria COG0652@1,COG0652@2 NA|NA|NA O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides MIPOCGNA_00684 904306.HMPREF9192_0423 1.3e-53 215.7 Bacilli pts33BCA ko:K02755,ko:K02756,ko:K02757 ko02060,map02060 M00271 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.2.11,4.A.1.2.2,4.A.1.2.5,4.A.1.2.6 Bacteria 1TP5X@1239,4HA0I@91061,COG1263@1,COG1263@2,COG1264@1,COG1264@2,COG2190@1,COG2190@2 NA|NA|NA G pts system MIPOCGNA_00685 1046629.Ssal_01653 6.8e-119 433.7 Bacilli pts33BCA 2.7.1.201,2.7.1.208,2.7.1.211 ko:K02755,ko:K02756,ko:K02757,ko:K02777,ko:K02808,ko:K02809,ko:K02810,ko:K02817,ko:K02818,ko:K02819,ko:K20107,ko:K20108 ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111 M00265,M00266,M00268,M00269,M00270,M00271,M00272,M00303,M00806 R00811,R02738,R02780,R04111,R04394,R05132,R08559 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.1,4.A.1.1.11,4.A.1.1.12,4.A.1.2.1,4.A.1.2.10,4.A.1.2.11,4.A.1.2.12,4.A.1.2.13,4.A.1.2.2,4.A.1.2.4,4.A.1.2.5,4.A.1.2.6,4.A.1.2.8,4.A.1.2.9 Bacteria 1TP5X@1239,4HA0I@91061,COG1263@1,COG1263@2,COG1264@1,COG1264@2,COG2190@1,COG2190@2 NA|NA|NA G pts system MIPOCGNA_00686 1046629.Ssal_01653 7.4e-25 119.0 Bacilli pts33BCA 2.7.1.201,2.7.1.208,2.7.1.211 ko:K02755,ko:K02756,ko:K02757,ko:K02777,ko:K02808,ko:K02809,ko:K02810,ko:K02817,ko:K02818,ko:K02819,ko:K20107,ko:K20108 ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111 M00265,M00266,M00268,M00269,M00270,M00271,M00272,M00303,M00806 R00811,R02738,R02780,R04111,R04394,R05132,R08559 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.1,4.A.1.1.11,4.A.1.1.12,4.A.1.2.1,4.A.1.2.10,4.A.1.2.11,4.A.1.2.12,4.A.1.2.13,4.A.1.2.2,4.A.1.2.4,4.A.1.2.5,4.A.1.2.6,4.A.1.2.8,4.A.1.2.9 Bacteria 1TP5X@1239,4HA0I@91061,COG1263@1,COG1263@2,COG1264@1,COG1264@2,COG2190@1,COG2190@2 NA|NA|NA G pts system MIPOCGNA_00687 1215915.BN193_08720 1.4e-09 70.1 Lactococcus uvrX 2.7.7.7 ko:K02346,ko:K03502,ko:K14161 ko00000,ko01000,ko03400 Bacteria 1TP42@1239,1YBFV@1357,4HA1P@91061,COG0389@1,COG0389@2 NA|NA|NA L impB/mucB/samB family MIPOCGNA_00688 264199.stu0509 2.6e-250 870.9 Bacilli cycA GO:0001761,GO:0001762,GO:0003333,GO:0003674,GO:0005215,GO:0005326,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015180,GO:0015187,GO:0015238,GO:0015318,GO:0015711,GO:0015804,GO:0015807,GO:0015808,GO:0015816,GO:0015849,GO:0015893,GO:0016020,GO:0022857,GO:0022858,GO:0022889,GO:0032328,GO:0032329,GO:0034220,GO:0042221,GO:0042493,GO:0042891,GO:0042895,GO:0042940,GO:0042941,GO:0042942,GO:0042943,GO:0042944,GO:0042945,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903825,GO:1905039 ko:K03293,ko:K11737 ko00000,ko02000 2.A.3.1,2.A.3.1.7 iECO111_1330.ECO111_5093,iECO26_1355.ECO26_5376,iEcHS_1320.EcHS_A4458,iSbBS512_1146.SbBS512_E4749,iYL1228.KPN_04601 Bacteria 1TP97@1239,4H9QX@91061,COG1113@1,COG1113@2 NA|NA|NA E permease MIPOCGNA_00689 264199.stu0508 4.5e-39 166.8 Bacilli ynzC Bacteria 1VEKJ@1239,4HNIB@91061,COG4224@1,COG4224@2 NA|NA|NA S UPF0291 protein MIPOCGNA_00690 322159.STER_0540 0.0 1285.0 Bacilli glyS GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.14 ko:K01879,ko:K14164 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iAPECO1_1312.APECO1_2891,iE2348C_1286.E2348C_3810,iECABU_c1320.ECABU_c40010,iECED1_1282.ECED1_4242,iECH74115_1262.ECH74115_4934,iECNA114_1301.ECNA114_3710,iECOK1_1307.ECOK1_4005,iECP_1309.ECP_3661,iECS88_1305.ECS88_3976,iECSF_1327.ECSF_3393,iECSP_1301.ECSP_4554,iECs_1301.ECs4442,iG2583_1286.G2583_4300,iJN678.glyS,iUMN146_1321.UM146_17960,iUTI89_1310.UTI89_C4099,ic_1306.c4378 Bacteria 1TNZ7@1239,4H9NT@91061,COG0751@1,COG0751@2 NA|NA|NA J Glycyl-tRNA synthetase beta subunit MIPOCGNA_00691 264199.stu0505 4.8e-176 623.6 Bacilli glyQ GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016874,GO:0016875,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0140098,GO:0140101 6.1.1.14 ko:K01878,ko:K14164 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iAF1260.b3560,iAF987.Gmet_2942,iJO1366.b3560,iPC815.YPO4072,iY75_1357.Y75_RS19360 Bacteria 1TPW8@1239,4HBCF@91061,COG0752@1,COG0752@2 NA|NA|NA J glycyl-tRNA synthetase alpha subunit MIPOCGNA_00692 904306.HMPREF9192_0417 5.2e-62 243.8 Bacilli Bacteria 1U601@1239,4HBYW@91061,COG3949@1,COG3949@2 NA|NA|NA S membrane MIPOCGNA_00693 264199.stu0504 8.7e-60 236.1 Bacteria Bacteria COG3949@1,COG3949@2 NA|NA|NA MIPOCGNA_00694 264199.stu0503 2.2e-25 120.9 Bacteria Bacteria COG3949@1,COG3949@2 NA|NA|NA MIPOCGNA_00695 264199.stu0502 2.5e-50 204.5 Bacteria Bacteria COG3949@1,COG3949@2 NA|NA|NA MIPOCGNA_00696 322159.STER_0537 8e-221 772.7 Bacilli nagA 3.5.1.25 ko:K01443 ko00520,ko01130,map00520,map01130 R02059 RC00166,RC00300 ko00000,ko00001,ko01000 Bacteria 1TPFK@1239,4HC6C@91061,COG1820@1,COG1820@2 NA|NA|NA G Belongs to the metallo-dependent hydrolases superfamily. NagA family MIPOCGNA_00697 1046629.Ssal_01661 1.2e-92 345.9 Bacilli nptA ko:K03324 ko00000,ko02000 2.A.58.2 Bacteria 1TP4K@1239,4HAZ0@91061,COG1283@1,COG1283@2 NA|NA|NA P COG1283 Na phosphate symporter MIPOCGNA_00698 322159.STER_0534 5.8e-149 533.5 Bacilli XK27_04800 Bacteria 1VAFW@1239,4HIFQ@91061,COG0561@1,COG0561@2 NA|NA|NA S Sucrose-6F-phosphate phosphohydrolase MIPOCGNA_00699 264199.stu0496 1.3e-103 382.5 Firmicutes mur1 ko:K02395 ko00000,ko02035 Bacteria 1UYRM@1239,COG1705@1,COG1705@2 NA|NA|NA NU mannosyl-glycoprotein MIPOCGNA_00700 322159.STER_0532 1.2e-52 212.2 Firmicutes glnB ko:K04751,ko:K04752 ko02020,map02020 ko00000,ko00001 Bacteria 1V9Z5@1239,COG0347@1,COG0347@2 NA|NA|NA K Belongs to the P(II) protein family MIPOCGNA_00701 322159.STER_0531 3.7e-232 810.4 Bacilli amt ko:K03320 ko00000,ko02000 1.A.11 Bacteria 1TQYG@1239,4HBGK@91061,COG0004@1,COG0004@2 NA|NA|NA P Ammonium Transporter MIPOCGNA_00705 435842.HMPREF0848_00929 6.9e-136 490.0 Bacilli tcyC2 3.6.3.21 ko:K02028,ko:K10010,ko:K16960 ko02010,map02010 M00234,M00236,M00585 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.10,3.A.1.3.13,3.A.1.3.14 Bacteria 1TNYD@1239,4H9WY@91061,COG1126@1,COG1126@2 NA|NA|NA E abc transporter atp-binding protein MIPOCGNA_00706 435842.HMPREF0848_00930 3e-114 417.9 Bacilli yxeN ko:K16959,ko:K16962 ko02010,map02010 M00585,M00586 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.13 Bacteria 1V1PT@1239,4HI18@91061,COG0765@1,COG0765@2 NA|NA|NA P ABC transporter, permease protein MIPOCGNA_00707 435842.HMPREF0848_00931 6.1e-107 393.7 Bacilli ytmL ko:K02029,ko:K10009,ko:K16958,ko:K16959 ko02010,map02010 M00234,M00236,M00585 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.10,3.A.1.3.13,3.A.1.3.14 Bacteria 1V4Q3@1239,4HDVS@91061,COG0765@1,COG0765@2 NA|NA|NA P ABC transporter (Permease MIPOCGNA_00708 435842.HMPREF0848_00932 2.4e-161 574.7 Bacilli ko:K16957 ko02010,map02010 M00585 ko00000,ko00001,ko00002,ko02000 3.A.1.3.13 Bacteria 1UX4B@1239,4HG72@91061,COG0834@1,COG0834@2 NA|NA|NA ET ABC transporter substrate-binding protein MIPOCGNA_00709 435842.HMPREF0848_00933 8.1e-161 573.2 Bacilli 4.1.1.37 ko:K01599,ko:K16957 ko00860,ko01100,ko01110,ko02010,map00860,map01100,map01110,map02010 M00121,M00585 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3.13 Bacteria 1TNYE@1239,4HQ5B@91061,COG0407@1,COG0407@2 NA|NA|NA H Uroporphyrinogen decarboxylase (URO-D) MIPOCGNA_00710 435842.HMPREF0848_00934 1.1e-83 315.8 Bacilli btuE 1.11.1.9 ko:K00432 ko00480,ko00590,ko04918,map00480,map00590,map04918 R00274,R07034,R07035 RC00011,RC00982 ko00000,ko00001,ko01000 Bacteria 1V3M3@1239,4HH5Q@91061,COG0386@1,COG0386@2 NA|NA|NA O Belongs to the glutathione peroxidase family MIPOCGNA_00711 1046629.Ssal_00807 2.4e-40 171.0 Bacilli ko:K15383 ko00000,ko02000 9.A.58.2 Bacteria 1VBI9@1239,4HN2M@91061,COG4095@1,COG4095@2 NA|NA|NA S Sugar efflux transporter for intercellular exchange MIPOCGNA_00712 1095727.HMPREF1117_1383 5.9e-23 113.2 Bacilli ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TSN2@1239,28K0P@1,2Z9QJ@2,4HU6K@91061 NA|NA|NA P FtsX-like permease family MIPOCGNA_00713 1316408.HSISM1_1672 3.2e-91 341.3 Bacilli ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 1U3WD@1239,4HV7M@91061,COG1136@1,COG1136@2 NA|NA|NA V abc transporter atp-binding protein MIPOCGNA_00714 889204.HMPREF9423_0305 3.9e-82 310.8 Bacilli Bacteria 1V2BY@1239,4HPW3@91061,COG1309@1,COG1309@2 NA|NA|NA K WHG domain MIPOCGNA_00715 1046629.Ssal_00802 9.4e-68 262.7 Bacilli ydhF Bacteria 1TQ12@1239,4HA57@91061,COG4989@1,COG4989@2 NA|NA|NA S Aldo keto reductase MIPOCGNA_00716 435842.HMPREF0848_00939 2.1e-71 275.0 Bacilli ydhF Bacteria 1TQ12@1239,4HA57@91061,COG4989@1,COG4989@2 NA|NA|NA S Aldo keto reductase MIPOCGNA_00718 264199.stu1363 7.4e-109 399.8 Bacilli XK27_02070 ko:K07078 ko00000 Bacteria 1V1CR@1239,4HD6W@91061,COG3560@1,COG3560@2 NA|NA|NA S nitroreductase MIPOCGNA_00719 322159.STER_1320 2.7e-149 534.6 Bacilli 1.13.11.2 ko:K07104 ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220 M00569 R00816,R04089,R05295,R05404,R05406,R07795 RC00387,RC00643,RC01075,RC01364,RC01914 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPRF@1239,4HAE7@91061,COG2514@1,COG2514@2 NA|NA|NA S glyoxalase MIPOCGNA_00720 264199.stu1366 3.6e-76 290.8 Bacilli ywnA Bacteria 1V6FK@1239,4HKZD@91061,COG1959@1,COG1959@2 NA|NA|NA K Transcriptional regulator MIPOCGNA_00721 322159.STER_1322 1.3e-154 552.4 Bacilli Bacteria 1V13S@1239,4HENM@91061,COG4814@1,COG4814@2 NA|NA|NA E Alpha/beta hydrolase of unknown function (DUF915) MIPOCGNA_00722 264199.stu1368 4.3e-231 807.0 Bacilli pts13C ko:K02761 ko00500,ko02060,map00500,map02060 M00275 R11170,R11172 RC00017,RC03206 ko00000,ko00001,ko00002,ko02000 4.A.3.2 Bacteria 1V5SI@1239,4HJTK@91061,COG1455@1,COG1455@2 NA|NA|NA G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane MIPOCGNA_00723 264199.stu1369 1.4e-110 405.6 Bacilli drgA Bacteria 1UYJU@1239,4HBVQ@91061,COG0778@1,COG0778@2 NA|NA|NA C Nitroreductase MIPOCGNA_00724 322159.STER_1325 9.9e-98 362.8 Firmicutes yoaK Bacteria 1V9ME@1239,COG3619@1,COG3619@2 NA|NA|NA S Protein of unknown function (DUF1275) MIPOCGNA_00725 264199.stu1371 6.8e-161 573.2 Bacilli yvgN Bacteria 1TPM1@1239,4HARE@91061,COG0656@1,COG0656@2 NA|NA|NA C reductase MIPOCGNA_00726 904306.HMPREF9192_1063 7.5e-180 636.3 Bacilli galE 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQ7N@1239,4H9U5@91061,COG1087@1,COG1087@2 NA|NA|NA M Belongs to the NAD(P)-dependent epimerase dehydratase family MIPOCGNA_00727 322159.STER_1332 3.6e-282 976.9 Bacilli XK27_07020 Bacteria 1TQYE@1239,4HDNX@91061,COG4868@1,COG4868@2 NA|NA|NA S Belongs to the UPF0371 family MIPOCGNA_00729 1203590.HMPREF1481_01686 4.8e-55 220.3 Bacilli Bacteria 1V4S4@1239,4HH0U@91061,COG0745@1,COG0745@2 NA|NA|NA K response regulator MIPOCGNA_00730 904306.HMPREF9192_1034 2.5e-31 141.0 Bacilli Bacteria 1V0E0@1239,2EXVW@1,33R50@2,4HBMI@91061 NA|NA|NA S Signal peptide protein, YSIRK family MIPOCGNA_00731 904306.HMPREF9192_1034 2.6e-31 141.0 Bacilli Bacteria 1V0E0@1239,2EXVW@1,33R50@2,4HBMI@91061 NA|NA|NA S Signal peptide protein, YSIRK family MIPOCGNA_00733 264199.stu1384 3.2e-59 234.2 Bacilli Bacteria 1VFMU@1239,2E59Z@1,33028@2,4HQG9@91061 NA|NA|NA MIPOCGNA_00734 322159.STER_1339 2.5e-264 917.5 Bacilli uvrX 2.7.7.7 ko:K02346,ko:K03502,ko:K14161 ko00000,ko01000,ko03400 Bacteria 1TP42@1239,4HA1P@91061,COG0389@1,COG0389@2 NA|NA|NA L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII MIPOCGNA_00735 264199.stu1386 6.5e-117 427.6 Bacilli Bacteria 1VBXK@1239,2CWIF@1,32SZQ@2,4HWJ5@91061 NA|NA|NA MIPOCGNA_00736 862970.SAIN_0151 2.9e-16 92.4 Streptococcus anginosus group Bacteria 1TVY9@1239,29H5Y@1,3043H@2,42EEJ@671232,4I4K4@91061 NA|NA|NA MIPOCGNA_00737 345219.Bcoa_1815 0.0 1380.5 Bacillus 3.1.21.3 ko:K01153 ko00000,ko01000,ko02048 Bacteria 1TP7S@1239,1ZCG9@1386,4HB5A@91061,COG0610@1,COG0610@2 NA|NA|NA L Subunit R is required for both nuclease and ATPase activities, but not for modification MIPOCGNA_00738 1033740.CAEW01000025_gene756 1.6e-73 283.5 Bacilli 3.1.21.3 ko:K01154 ko00000,ko01000,ko02048 Bacteria 1TP5N@1239,4HM7C@91061,COG0732@1,COG0732@2 NA|NA|NA V Type I restriction modification DNA specificity domain MIPOCGNA_00739 1027396.LMOSA_12070 3e-292 1011.1 Listeriaceae hsdM 2.1.1.72 ko:K03427 ko00000,ko01000,ko02048 Bacteria 1TPGZ@1239,26IQ9@186820,4HA1J@91061,COG0286@1,COG0286@2 NA|NA|NA V Type I restriction-modification system MIPOCGNA_00740 264199.stu1392 0.0 1402.5 Bacilli Bacteria 1VATJ@1239,4HG1M@91061,COG1216@1,COG1216@2,COG1442@1,COG1442@2 NA|NA|NA M family 8 MIPOCGNA_00741 264199.stu0373 4.1e-107 394.0 Bacilli Bacteria 1W4V4@1239,2F8BM@1,340QP@2,4HR72@91061 NA|NA|NA S Domain of unknown function (DUF1803) MIPOCGNA_00742 264199.stu0374 7.8e-102 376.3 Bacilli ygaC ko:K07586 ko00000 Bacteria 1TRX8@1239,4H9NM@91061,COG3557@1,COG3557@2 NA|NA|NA J Belongs to the UPF0374 family MIPOCGNA_00743 264199.stu0375 7.3e-133 479.9 Bacilli recX GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0019899,GO:0031668,GO:0033554,GO:0043086,GO:0044092,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496 2.4.1.337 ko:K03565,ko:K19002 ko00561,ko01100,map00561,map01100 R10850 RC00005,RC00059 ko00000,ko00001,ko01000,ko01003,ko03400 GT4 Bacteria 1V72V@1239,4HKE3@91061,COG2137@1,COG2137@2 NA|NA|NA S Regulatory protein RecX MIPOCGNA_00744 264199.stu0376 1.4e-259 901.7 Bacilli rumA 2.1.1.190,2.1.1.35 ko:K00557,ko:K03215 ko00000,ko01000,ko03009,ko03016 Bacteria 1TP4H@1239,4HA6M@91061,COG2265@1,COG2265@2 NA|NA|NA J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family MIPOCGNA_00745 322159.STER_0424 6.7e-192 676.4 Bacilli asnA GO:0003674,GO:0003824,GO:0004071,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006529,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009987,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.1.1 ko:K01914 ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230 R00483 RC00010 ko00000,ko00001,ko01000 iAPECO1_1312.APECO1_2719,iECOK1_1307.ECOK1_4193,iECS88_1305.ECS88_4166,iUMN146_1321.UM146_18910,iUTI89_1310.UTI89_C4299 Bacteria 1TP28@1239,4HAEC@91061,COG2502@1,COG2502@2 NA|NA|NA E aspartate--ammonia ligase MIPOCGNA_00746 322159.STER_0425 2e-255 887.9 Bacilli lysC GO:0000166,GO:0003674,GO:0003824,GO:0004072,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017076,GO:0019202,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 iYO844.BSU03790 Bacteria 1TPQJ@1239,4HAEP@91061,COG0527@1,COG0527@2 NA|NA|NA E Belongs to the aspartokinase family MIPOCGNA_00747 322159.STER_0426 1.6e-114 418.7 Bacilli Bacteria 1V7XM@1239,4IPJK@91061,COG0637@1,COG0637@2 NA|NA|NA S Haloacid dehalogenase-like hydrolase MIPOCGNA_00748 264199.stu0380 4e-139 500.7 Bacilli phaB GO:0003674,GO:0003824,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006635,GO:0006636,GO:0008150,GO:0008152,GO:0008610,GO:0009056,GO:0009058,GO:0009062,GO:0009987,GO:0016042,GO:0016053,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016860,GO:0016863,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033559,GO:0034017,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:0072330,GO:1901575,GO:1901576 5.3.3.14,5.3.3.18 ko:K15866,ko:K18474 ko00061,ko00360,ko01120,map00061,map00360,map01120 R07639,R09837,R09839 RC00004,RC00326,RC01078,RC02689,RC03003 ko00000,ko00001,ko01000,ko01004 Bacteria 1TQ2V@1239,4HBT0@91061,COG1024@1,COG1024@2 NA|NA|NA I Belongs to the enoyl-CoA hydratase isomerase family MIPOCGNA_00749 322159.STER_0428 4e-72 277.3 Bacilli marR Bacteria 1V6GY@1239,4HIMR@91061,COG1846@1,COG1846@2 NA|NA|NA K Transcriptional regulator, MarR family MIPOCGNA_00750 322159.STER_0429 2.3e-173 614.8 Bacilli fabH 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 1TP0K@1239,4HATK@91061,COG0332@1,COG0332@2 NA|NA|NA I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids MIPOCGNA_00751 1046629.Ssal_01806 3.3e-30 137.1 Bacilli acpP GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 ko:K02078 ko00000,ko00001 Bacteria 1VGIY@1239,4HP0V@91061,COG0236@1,COG0236@2 NA|NA|NA IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis MIPOCGNA_00752 264199.stu0385 1.2e-172 612.5 Bacilli fabK 1.3.1.9 ko:K02371 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000,ko01004 iHN637.CLJU_RS20775 Bacteria 1TPC3@1239,4H9T0@91061,COG2070@1,COG2070@2 NA|NA|NA S 2-Nitropropane dioxygenase MIPOCGNA_00753 264199.stu0386 1.9e-164 585.1 Bacilli fabD 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 1TPB7@1239,4HBCU@91061,COG0331@1,COG0331@2 NA|NA|NA I Malonyl CoA-acyl carrier protein transacylase MIPOCGNA_00754 322159.STER_0433 1.6e-126 458.8 Bacilli Bacteria 1TP76@1239,4HAA6@91061,COG1028@1,COG1028@2 NA|NA|NA IQ reductase MIPOCGNA_00755 322159.STER_0434 1.5e-233 815.1 Bacilli fabF 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 1TPA7@1239,4H9SD@91061,COG0304@1,COG0304@2 NA|NA|NA I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP MIPOCGNA_00756 322159.STER_0435 7e-57 226.9 Bacilli accB 2.3.1.12,4.1.1.3 ko:K00627,ko:K01571,ko:K02160 ko00010,ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00010,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00307,M00376 R00209,R00217,R00742,R02569 RC00004,RC00040,RC00367,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000,ko02000 3.B.1.1.1 Bacteria 1VAB7@1239,4HKCS@91061,COG0511@1,COG0511@2 NA|NA|NA I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA MIPOCGNA_00757 1046629.Ssal_01800 4.3e-71 273.9 Bacilli fabZ 3.5.1.108,4.2.1.59 ko:K02372,ko:K16363 ko00061,ko00540,ko00780,ko01100,ko01212,map00061,map00540,map00780,map01100,map01212 M00060,M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965,R07764,R10117,R10121 RC00166,RC00300,RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004,ko01005 Bacteria 1V6EX@1239,4HGX1@91061,COG0764@1,COG0764@2 NA|NA|NA I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs MIPOCGNA_00758 322159.STER_0437 5.4e-256 889.8 Bacilli accC GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 iSF_1195.SF3294 Bacteria 1TP16@1239,4HARK@91061,COG0439@1,COG0439@2 NA|NA|NA I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism MIPOCGNA_00759 322159.STER_0438 1.3e-159 568.9 Bacilli accD 2.1.3.15,6.4.1.2 ko:K01962,ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP4U@1239,4HAI7@91061,COG0777@1,COG0777@2 NA|NA|NA I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA MIPOCGNA_00760 322159.STER_0439 6.7e-139 500.0 Bacilli accA 2.1.3.15,6.4.1.2 ko:K01962,ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 Bacteria 1UHNS@1239,4HA4C@91061,COG0825@1,COG0825@2 NA|NA|NA I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA MIPOCGNA_00761 1046629.Ssal_01795 4.7e-90 337.0 Bacilli luxS GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0007154,GO:0007267,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009116,GO:0009119,GO:0009372,GO:0009987,GO:0010699,GO:0016053,GO:0016829,GO:0016846,GO:0017144,GO:0019284,GO:0019752,GO:0023052,GO:0033353,GO:0034641,GO:0042278,GO:0043094,GO:0043102,GO:0043436,GO:0043768,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0046128,GO:0046394,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0051704,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901657 4.4.1.21 ko:K07173 ko00270,ko01100,ko01230,ko02024,ko02026,ko05111,map00270,map01100,map01230,map02024,map02026,map05111 M00609 R01291 RC00069,RC01929 ko00000,ko00001,ko00002,ko01000 iECIAI39_1322.ECIAI39_2877,iPC815.YPO3300 Bacteria 1V1V3@1239,4HFR0@91061,COG1854@1,COG1854@2 NA|NA|NA H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) MIPOCGNA_00762 264199.stu0397 1.3e-205 722.6 Bacilli rny GO:0003674,GO:0005488,GO:0005515,GO:0042802 ko:K05802,ko:K18682 ko03018,map03018 ko00000,ko00001,ko01000,ko02000,ko03019 1.A.23.1.1 Bacteria 1TP48@1239,4HC9J@91061,COG1418@1,COG1418@2,COG4372@1,COG4372@2 NA|NA|NA D Endoribonuclease that initiates mRNA decay MIPOCGNA_00763 264199.stu0398 1.8e-84 318.5 Firmicutes ko:K07485 ko00000 Bacteria 1TQ93@1239,COG3464@1,COG3464@2 NA|NA|NA L Transposase MIPOCGNA_00764 904306.HMPREF9192_0316 1.2e-121 442.6 Bacilli fruR ko:K03436 ko00000,ko03000 Bacteria 1TSF8@1239,4HDT9@91061,COG1349@1,COG1349@2 NA|NA|NA K transcriptional MIPOCGNA_00765 264199.stu0400 3.8e-165 587.4 Bacilli pfkB 2.7.1.11,2.7.1.56 ko:K00882,ko:K16370 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00345 R00756,R02071,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQ36@1239,4HANU@91061,COG1105@1,COG1105@2 NA|NA|NA H Belongs to the carbohydrate kinase PfkB family. LacC subfamily MIPOCGNA_00766 1046629.Ssal_01791 0.0 1173.7 Bacilli fruA 2.7.1.202 ko:K02768,ko:K02769,ko:K02770,ko:K02806 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 Bacteria 1TPKU@1239,4H9KR@91061,COG1299@1,COG1299@2,COG1445@1,COG1445@2,COG1762@1,COG1762@2 NA|NA|NA G phosphotransferase system MIPOCGNA_00767 264199.stu0408 3e-259 900.6 Bacilli gor GO:0000166,GO:0003674,GO:0003824,GO:0004362,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015036,GO:0015037,GO:0015038,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071949,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.7 ko:K00383 ko00480,ko04918,map00480,map04918 R00094,R00115 RC00011 ko00000,ko00001,ko01000 iZ_1308.Z4900 Bacteria 1TQFH@1239,4HCT8@91061,COG1249@1,COG1249@2 NA|NA|NA C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family MIPOCGNA_00768 264199.stu0409 1.7e-240 838.2 Bacilli folC 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0166 Bacteria 1TPX5@1239,4HBJM@91061,COG0285@1,COG0285@2 NA|NA|NA H Belongs to the folylpolyglutamate synthase family MIPOCGNA_00770 264199.stu0411 5.7e-211 740.0 Bacilli iscS2 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 Bacteria 1TP21@1239,4HAEE@91061,COG1104@1,COG1104@2 NA|NA|NA E Cysteine sulfinate desulfinase cysteine desulfurase and related enzymes MIPOCGNA_00771 264199.stu0412 1.8e-226 791.6 Bacilli thiI GO:0000049,GO:0002937,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017144,GO:0018130,GO:0019438,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042364,GO:0042723,GO:0042724,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.8.1.4 ko:K03151 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07461 ko00000,ko00001,ko01000,ko03016 iECNA114_1301.ECNA114_0400,iECO26_1355.ECO26_0455,iECSF_1327.ECSF_0383,iSDY_1059.SDY_0307 Bacteria 1TPNW@1239,4HAV9@91061,COG0301@1,COG0301@2 NA|NA|NA H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS MIPOCGNA_00772 322159.STER_0452 4.2e-294 1016.5 Bacilli gtf1 2.4.1.52 ko:K00712 ko00000,ko01000,ko01003 GT4 Bacteria 1TR6K@1239,4HGDG@91061,COG0438@1,COG0438@2 NA|NA|NA M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon MIPOCGNA_00773 264199.stu0414 3e-256 890.6 Firmicutes gtf2 Bacteria 1TQZR@1239,COG0438@1,COG0438@2 NA|NA|NA M A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1 MIPOCGNA_00774 1046629.Ssal_01780 4.9e-39 167.2 Bacteria 2.3.1.128 ko:K03789 ko00000,ko01000,ko03009 Bacteria COG0454@1,COG0456@2 NA|NA|NA K acetyltransferase MIPOCGNA_00775 1046629.Ssal_01780 6.4e-29 132.9 Bacteria 2.3.1.128 ko:K03789 ko00000,ko01000,ko03009 Bacteria COG0454@1,COG0456@2 NA|NA|NA K acetyltransferase MIPOCGNA_00776 264199.stu0417 4.5e-49 200.3 Bacilli rplU GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02888 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V9YH@1239,4HIGK@91061,COG0261@1,COG0261@2 NA|NA|NA J This protein binds to 23S rRNA in the presence of protein L20 MIPOCGNA_00777 1046629.Ssal_01778 1.5e-46 191.8 Bacilli rpmA GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904 ko:K02899 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V6HW@1239,4HIMN@91061,COG0211@1,COG0211@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL27 family MIPOCGNA_00778 1046629.Ssal_01777 9.1e-87 326.2 Bacteria ydaF_2 Bacteria COG1670@1,COG1670@2 NA|NA|NA J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins MIPOCGNA_00779 264199.stu1445 0.0 1255.4 Bacilli amiA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02035,ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 1TQVS@1239,4HCCB@91061,COG4166@1,COG4166@2 NA|NA|NA E ABC transporter, substrate-binding protein, family 5 MIPOCGNA_00780 904306.HMPREF9192_0942 4.2e-270 936.8 Bacilli amiC GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0022857,GO:0051179,GO:0051234,GO:0055085 ko:K02033,ko:K13894,ko:K15581 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00349,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.21,3.A.1.5.24,3.A.1.5.25 Bacteria 1UY5U@1239,4HEZK@91061,COG0601@1,COG0601@2 NA|NA|NA P ABC transporter (Permease MIPOCGNA_00781 264199.stu1440 3.1e-167 594.3 Bacilli amiD ko:K15582 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 1TP4R@1239,4HE8S@91061,COG1173@1,COG1173@2 NA|NA|NA P ABC transporter (Permease MIPOCGNA_00782 264199.stu1439 7.1e-203 713.0 Bacilli oppD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02031,ko:K02032,ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 1TP6E@1239,4H9MR@91061,COG0444@1,COG0444@2 NA|NA|NA P Belongs to the ABC transporter superfamily MIPOCGNA_00783 264199.stu1438 7.3e-172 609.8 Bacilli oppF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02032,ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 1V36J@1239,4HCM4@91061,COG4608@1,COG4608@2 NA|NA|NA P Belongs to the ABC transporter superfamily MIPOCGNA_00784 322159.STER_1404 5.6e-133 480.3 Bacteria ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria COG1131@1,COG1131@2 NA|NA|NA V ATPase activity MIPOCGNA_00785 264199.stu1436 9.8e-121 439.5 Bacilli skfE ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TPUP@1239,4HGHM@91061,COG1131@1,COG1131@2 NA|NA|NA V abc transporter atp-binding protein MIPOCGNA_00786 322159.STER_1402 8.6e-63 246.1 Bacilli yvoA_1 ko:K07979 ko00000,ko03000 Bacteria 1VFD0@1239,4HNIT@91061,COG1725@1,COG1725@2 NA|NA|NA K Transcriptional MIPOCGNA_00787 322159.STER_1401 2.1e-148 531.6 Bacilli supH Bacteria 1V2JE@1239,4IPK2@91061,COG0561@1,COG0561@2 NA|NA|NA S overlaps another CDS with the same product name MIPOCGNA_00788 322159.STER_1400 5.3e-150 537.0 Bacilli XK27_02985 Bacteria 1TR2E@1239,4HGA9@91061,COG0561@1,COG0561@2 NA|NA|NA S overlaps another CDS with the same product name MIPOCGNA_00789 264199.stu1432 1.3e-212 745.7 Bacilli ftsY ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 Bacteria 1TPRI@1239,4HA6A@91061,COG0552@1,COG0552@2 NA|NA|NA U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) MIPOCGNA_00790 264199.stu1431 2e-112 411.8 Bacilli gmk GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 iYO844.BSU15680 Bacteria 1TP0M@1239,4HAYW@91061,COG0194@1,COG0194@2 NA|NA|NA F Essential for recycling GMP and indirectly, cGMP MIPOCGNA_00791 264199.stu1430 1.1e-44 185.7 Bacteria rpoZ GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria COG1758@1,COG1758@2 NA|NA|NA K DNA-directed 5'-3' RNA polymerase activity MIPOCGNA_00792 264199.stu1429 0.0 1583.5 Bacilli priA GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 ko:K04066 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 1TNYB@1239,4H9WW@91061,COG1198@1,COG1198@2 NA|NA|NA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA MIPOCGNA_00793 264199.stu1428 1e-173 615.9 Bacilli fmt GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 R03940 RC00026,RC00165 ko00000,ko00001,ko01000 iSB619.SA_RS06010 Bacteria 1TQ32@1239,4HART@91061,COG0223@1,COG0223@2 NA|NA|NA J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus MIPOCGNA_00794 264199.stu1427 1.7e-246 858.2 Bacilli sun GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176 ko:K03500 ko00000,ko01000,ko03009 Bacteria 1TP3N@1239,4HBQ6@91061,COG0144@1,COG0144@2,COG0781@1,COG0781@2 NA|NA|NA J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA MIPOCGNA_00795 264199.stu1426 3.2e-130 471.1 Bacilli stp 3.1.3.16 ko:K20074 ko00000,ko01000,ko01009 Bacteria 1V6K5@1239,4HCDR@91061,COG0631@1,COG0631@2 NA|NA|NA T phosphatase MIPOCGNA_00796 322159.STER_1392 2.9e-305 1053.9 Bacilli prkC GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701 2.7.11.1 ko:K12132 ko00000,ko01000,ko01001 Bacteria 1TP3F@1239,4H9KD@91061,COG0515@1,COG0515@2,COG2815@1,COG2815@2 NA|NA|NA KLT serine threonine protein kinase MIPOCGNA_00797 264199.stu1422 9.1e-119 433.0 Bacteria yvqF ko:K11622 ko02020,map02020 ko00000,ko00001 Bacteria COG4758@1,COG4758@2 NA|NA|NA KT membrane MIPOCGNA_00798 264199.stu1421 3.8e-174 617.5 Bacilli vraS 2.7.13.3 ko:K07673,ko:K07681,ko:K11617 ko02020,map02020 M00471,M00480,M00481,M00754 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1TPDG@1239,4HC7E@91061,COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase MIPOCGNA_00799 322159.STER_1387 2.2e-114 418.3 Bacilli vraR ko:K07694,ko:K11618 ko02020,map02020 M00480,M00481,M00754 ko00000,ko00001,ko00002,ko02022 Bacteria 1TQ1U@1239,4HA4B@91061,COG2197@1,COG2197@2 NA|NA|NA K Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain MIPOCGNA_00802 322159.STER_1384 5.8e-94 350.1 Bacilli rimM GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 ko:K02860 ko00000,ko03009 Bacteria 1V6HD@1239,4HH3H@91061,COG0806@1,COG0806@2 NA|NA|NA J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes MIPOCGNA_00803 264199.stu1418 1.4e-135 488.8 Bacilli trmD GO:0000287,GO:0001510,GO:0002939,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050518,GO:0052906,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228,4.6.1.12 ko:K00554,ko:K01770 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R00597,R05637 RC00002,RC00003,RC00334,RC01440 ko00000,ko00001,ko00002,ko01000,ko03016 Bacteria 1TPBV@1239,4HBFV@91061,COG0336@1,COG0336@2 NA|NA|NA J Belongs to the RNA methyltransferase TrmD family MIPOCGNA_00804 264199.stu1417 2.5e-186 657.9 Bacilli trxB1 1.18.1.2,1.19.1.1 ko:K21567 ko00000,ko01000 Bacteria 1TRPN@1239,4H9V7@91061,COG0492@1,COG0492@2 NA|NA|NA C Ferredoxin--NADP reductase MIPOCGNA_00805 264199.stu1416 0.0 1441.0 Bacilli ftsK GO:0000003,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0019954,GO:0030436,GO:0031323,GO:0031326,GO:0032502,GO:0043934,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 ko:K03466 ko00000,ko03036 3.A.12 Bacteria 1TPJR@1239,4H9WA@91061,COG1674@1,COG1674@2 NA|NA|NA D Belongs to the FtsK SpoIIIE SftA family MIPOCGNA_00806 1046629.Ssal_00653 3.6e-117 427.9 Bacilli pulA 3.2.1.41 ko:K01200 ko00500,ko01100,ko01110,map00500,map01100,map01110 R02111 ko00000,ko00001,ko01000 CBM48,GH13 Bacteria 1TP3M@1239,4HBP5@91061,COG1523@1,COG1523@2 NA|NA|NA G belongs to the glycosyl hydrolase 13 family MIPOCGNA_00807 904306.HMPREF9192_0969 6.9e-57 226.5 Bacilli pulA 3.2.1.41 ko:K01200 ko00500,ko01100,ko01110,map00500,map01100,map01110 R02111 ko00000,ko00001,ko01000 CBM48,GH13 Bacteria 1TP3M@1239,4HBP5@91061,COG1523@1,COG1523@2 NA|NA|NA G belongs to the glycosyl hydrolase 13 family MIPOCGNA_00808 1046629.Ssal_00653 1e-11 74.7 Bacilli pulA 3.2.1.41 ko:K01200 ko00500,ko01100,ko01110,map00500,map01100,map01110 R02111 ko00000,ko00001,ko01000 CBM48,GH13 Bacteria 1TP3M@1239,4HBP5@91061,COG1523@1,COG1523@2 NA|NA|NA G belongs to the glycosyl hydrolase 13 family MIPOCGNA_00809 1046629.Ssal_00653 2.1e-82 312.0 Bacilli pulA 3.2.1.41 ko:K01200 ko00500,ko01100,ko01110,map00500,map01100,map01110 R02111 ko00000,ko00001,ko01000 CBM48,GH13 Bacteria 1TP3M@1239,4HBP5@91061,COG1523@1,COG1523@2 NA|NA|NA G belongs to the glycosyl hydrolase 13 family MIPOCGNA_00810 1046629.Ssal_00654 5.9e-25 119.4 Bacilli glgB GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033554,GO:0033692,GO:0034637,GO:0034645,GO:0040007,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0071944,GO:1901576 2.4.1.18,3.2.1.141,3.2.1.20 ko:K00700,ko:K01187,ko:K01236,ko:K17734 ko00052,ko00500,ko01100,ko01110,map00052,map00500,map01100,map01110 M00565 R00028,R00801,R00802,R02110,R06087,R06088,R09995,R11256 RC00028,RC00049,RC00077 ko00000,ko00001,ko00002,ko01000,ko01002,ko04147 CBM48,GH13,GH31 iAPECO1_1312.APECO1_3025,iECNA114_1301.ECNA114_3542,iECOK1_1307.ECOK1_3857,iECS88_1305.ECS88_3830,iECSF_1327.ECSF_3253,iJN678.glgB,iLF82_1304.LF82_0837,iNRG857_1313.NRG857_17030,iUTI89_1310.UTI89_C3941 Bacteria 1TP4M@1239,4HAPM@91061,COG0296@1,COG0296@2 NA|NA|NA G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position MIPOCGNA_00811 984892.SPSE_1802 0.0 1399.4 Staphylococcaceae traI 5.99.1.2 ko:K03169 ko00000,ko01000,ko03032 Bacteria 1TPJD@1239,4GY8J@90964,4HAZV@91061,COG0550@1,COG0550@2 NA|NA|NA L Bacterial DNA topoisomerase I DNA-binding domain MIPOCGNA_00812 984892.SPSE_1803 1.3e-105 389.0 Staphylococcaceae tnpR Bacteria 1UZM8@1239,4H1NJ@90964,4IQ67@91061,COG1961@1,COG1961@2 NA|NA|NA L Resolvase, N terminal domain MIPOCGNA_00814 1449338.JQLU01000001_gene928 1.6e-282 978.0 Carnobacteriaceae repE Bacteria 1UBUD@1239,27H8Y@186828,4HB0A@91061,COG1959@1,COG1959@2 NA|NA|NA K Primase C terminal 1 (PriCT-1) MIPOCGNA_00815 565653.EGBG_00002 4.2e-22 110.5 Enterococcaceae Bacteria 1U14H@1239,29K9A@1,3076M@2,4B5N1@81852,4IAKD@91061 NA|NA|NA K Helix-turn-helix XRE-family like proteins MIPOCGNA_00816 1449338.JQLU01000001_gene926 6.7e-44 184.5 Bacteria ko:K06236 ko04151,ko04510,ko04512,ko04611,ko04926,ko04933,ko04974,ko05146,ko05165,map04151,map04510,map04512,map04611,map04926,map04933,map04974,map05146,map05165 ko00000,ko00001,ko00536,ko04516 Bacteria COG3468@1,COG3468@2 NA|NA|NA MU cell adhesion MIPOCGNA_00817 1158614.I592_04089 1.4e-62 245.4 Enterococcaceae Bacteria 1TZKJ@1239,2BKCB@1,32ESV@2,4B3AK@81852,4I8VQ@91061 NA|NA|NA MIPOCGNA_00818 1158604.I591_02897 1.3e-118 433.0 Enterococcaceae Bacteria 1TYVH@1239,2BNIR@1,32H7D@2,4B25T@81852,4I813@91061 NA|NA|NA MIPOCGNA_00819 1449338.JQLU01000001_gene923 6.7e-141 506.9 Bacilli Bacteria 1VPIB@1239,2EN0Y@1,33FP4@2,4HRWI@91061 NA|NA|NA MIPOCGNA_00820 1158614.I592_04086 4.7e-155 553.9 Enterococcaceae Bacteria 1TYQU@1239,29IXP@1,305V2@2,4B0IU@81852,4I7VU@91061 NA|NA|NA MIPOCGNA_00821 1449338.JQLU01000001_gene921 1e-309 1068.5 Bacilli traK ko:K03205 ko03070,map03070 M00333 ko00000,ko00001,ko00002,ko02044 3.A.7 Bacteria 1TPCF@1239,4HPUX@91061,COG3505@1,COG3505@2 NA|NA|NA U TraM recognition site of TraD and TraG MIPOCGNA_00822 1158614.I592_04084 7.8e-60 236.5 Enterococcaceae Bacteria 1TZDJ@1239,29JBM@1,30692@2,4B2W3@81852,4I8MR@91061 NA|NA|NA MIPOCGNA_00823 1158614.I592_04083 6.6e-88 330.1 Enterococcaceae Bacteria 1TZ2U@1239,2BNTC@1,32HGZ@2,4B23E@81852,4I89U@91061 NA|NA|NA MIPOCGNA_00824 1449338.JQLU01000001_gene918 1.1e-211 742.3 Bacilli ko:K08306 ko00000,ko01000,ko01011 GH23 Bacteria 1VD4A@1239,4HN7R@91061,COG0741@1,COG0741@2,COG3942@1,COG3942@2 NA|NA|NA M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) MIPOCGNA_00825 1449338.JQLU01000001_gene917 7.7e-239 832.8 Bacilli Bacteria 1V1PS@1239,4HGKF@91061,COG4499@1,COG4499@2 NA|NA|NA S WXG100 protein secretion system (Wss), protein YukC MIPOCGNA_00826 1158614.I592_04080 0.0 1250.0 Enterococcaceae traE Bacteria 1TPDR@1239,4B6CD@81852,4IQVJ@91061,COG3451@1,COG3451@2 NA|NA|NA U AAA-like domain MIPOCGNA_00827 1158604.I591_02861 3.4e-112 411.0 Enterococcaceae Bacteria 1U1A7@1239,2DJTB@1,3079F@2,4B1TP@81852,4IF6E@91061 NA|NA|NA MIPOCGNA_00828 1158604.I591_02860 3.7e-53 214.2 Enterococcaceae Bacteria 1U5XN@1239,2DKMP@1,309YA@2,4B2JT@81852,4IFKZ@91061 NA|NA|NA MIPOCGNA_00829 1158604.I591_02859 9.3e-53 212.6 Enterococcaceae Bacteria 1U5UX@1239,2DKM7@1,309WM@2,4B3B7@81852,4IFII@91061 NA|NA|NA S Cag pathogenicity island, type IV secretory system MIPOCGNA_00830 1158614.I592_04076 0.0 1184.9 Enterococcaceae traA Bacteria 1VQWC@1239,4B1SS@81852,4HD6B@91061,COG0507@1,COG0507@2 NA|NA|NA L MobA/MobL family MIPOCGNA_00831 1158604.I591_02857 5.6e-25 120.2 Enterococcaceae Bacteria 1TZIH@1239,29JEP@1,306C6@2,4B36S@81852,4I8T5@91061 NA|NA|NA MIPOCGNA_00832 1449338.JQLU01000001_gene970 3.6e-36 157.1 Bacilli Bacteria 1VKZC@1239,2EJES@1,33D5R@2,4HRGI@91061 NA|NA|NA MIPOCGNA_00833 1158614.I592_04073 1.5e-25 121.7 Enterococcaceae Bacteria 1U0Z9@1239,29K6C@1,3073S@2,4B5GH@81852,4IAFF@91061 NA|NA|NA MIPOCGNA_00834 1158604.I591_02854 2.3e-87 328.2 Enterococcaceae ko:K03686 ko00000,ko03029,ko03110 Bacteria 1V7Z6@1239,4AZSE@81852,4HW1S@91061,COG2214@1,COG2214@2 NA|NA|NA O DnaJ molecular chaperone homology domain MIPOCGNA_00835 1140001.I571_02903 2.1e-54 218.0 Enterococcaceae Bacteria 1VZP7@1239,2FB10@1,3437P@2,4B2NI@81852,4HYST@91061 NA|NA|NA MIPOCGNA_00836 1211817.CCAT010000030_gene2061 1.1e-145 522.7 Clostridia 2.7.1.176 ko:K16214 ko00000,ko01000,ko02048 Bacteria 1V1MA@1239,24WRX@186801,COG4185@1,COG4185@2 NA|NA|NA S Zeta toxin MIPOCGNA_00837 996306.SSUR61_1136 2.3e-41 174.5 Bacilli Bacteria 1VGIV@1239,2E6PE@1,3319S@2,4I030@91061 NA|NA|NA S Bacterial epsilon antitoxin MIPOCGNA_00838 1449338.JQLU01000001_gene961 2.8e-31 140.6 Firmicutes Bacteria 1V8Y3@1239,2BT6B@1,32NBG@2 NA|NA|NA S Omega Transcriptional Repressor MIPOCGNA_00839 1140001.I571_02898 3.9e-162 577.4 Enterococcaceae Bacteria 1TP8S@1239,4B06Q@81852,4HAYM@91061,COG1192@1,COG1192@2 NA|NA|NA D AAA domain MIPOCGNA_00840 1121865.OMW_01688 3.6e-16 89.7 Enterococcaceae Bacteria 1VHZC@1239,2A8RU@1,30XUI@2,4B49K@81852,4IBX8@91061 NA|NA|NA MIPOCGNA_00841 1121864.OMO_00465 2.1e-134 485.0 Enterococcaceae ksgA GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182,2.1.1.184 ko:K00561,ko:K02528 R10716 RC00003,RC03257 br01600,ko00000,ko01000,ko01504,ko03009 Bacteria 1UY9S@1239,4B19I@81852,4HC16@91061,COG0030@1,COG0030@2 NA|NA|NA J Ribosomal RNA adenine dimethylase MIPOCGNA_00842 1229517.AMFD01000016_gene840 1.2e-52 212.2 Lactococcus tnp ko:K07498 ko00000 Bacteria 1TTKR@1239,1YB3Z@1357,4HCB4@91061,COG3316@1,COG3316@2 NA|NA|NA L Transposase IS66 family MIPOCGNA_00843 264199.stu0078 5.6e-129 467.2 Bacilli dacA GO:0003674,GO:0003824,GO:0004175,GO:0004180,GO:0004185,GO:0005575,GO:0005618,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0009002,GO:0016787,GO:0017171,GO:0019538,GO:0030312,GO:0043170,GO:0044238,GO:0044464,GO:0070008,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 3.4.16.4 ko:K01286,ko:K07258 ko00550,ko01100,map00550,map01100 ko00000,ko00001,ko01000,ko01002,ko01011 Bacteria 1TQN0@1239,4HBD4@91061,COG1686@1,COG1686@2 NA|NA|NA M Belongs to the peptidase S11 family MIPOCGNA_00844 904306.HMPREF9192_0524 3.9e-59 234.2 Bacilli dacA GO:0003674,GO:0003824,GO:0004175,GO:0004180,GO:0004185,GO:0005575,GO:0005618,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0009002,GO:0016787,GO:0017171,GO:0019538,GO:0030312,GO:0043170,GO:0044238,GO:0044464,GO:0070008,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 3.4.16.4 ko:K01286,ko:K07258 ko00550,ko01100,map00550,map01100 ko00000,ko00001,ko01000,ko01002,ko01011 Bacteria 1TQN0@1239,4HBD4@91061,COG1686@1,COG1686@2 NA|NA|NA M Belongs to the peptidase S11 family MIPOCGNA_00845 322159.STER_0113 7.1e-231 806.2 Bacilli dacA GO:0003674,GO:0003824,GO:0004175,GO:0004180,GO:0004185,GO:0005575,GO:0005618,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0009002,GO:0016787,GO:0017171,GO:0019538,GO:0030312,GO:0043170,GO:0044238,GO:0044464,GO:0070008,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 3.4.16.4 ko:K01286,ko:K07258 ko00550,ko01100,map00550,map01100 ko00000,ko00001,ko01000,ko01002,ko01011 Bacteria 1TQN0@1239,4HBD4@91061,COG1686@1,COG1686@2 NA|NA|NA M Belongs to the peptidase S11 family MIPOCGNA_00846 264199.stu0081 0.0 1352.4 Bacilli pnp GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 Bacteria 1TQDW@1239,4H9Z3@91061,COG1185@1,COG1185@2 NA|NA|NA J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction MIPOCGNA_00847 264199.stu0082 2.2e-142 511.5 Bacilli Bacteria 1VY65@1239,2F67I@1,33YRI@2,4HXHY@91061 NA|NA|NA S SseB protein N-terminal domain MIPOCGNA_00848 264199.stu0083 1.1e-112 412.5 Bacilli cysE 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 Bacteria 1TR42@1239,4HAKS@91061,COG1045@1,COG1045@2 NA|NA|NA E serine acetyltransferase MIPOCGNA_00849 264199.stu0084 1.5e-255 888.3 Bacilli cysS GO:0000166,GO:0001871,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030246,GO:0030247,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065 6.1.1.16,6.3.1.13 ko:K01883,ko:K15526 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iECUMN_1333.ECUMN_0566,iJN746.PP_2905 Bacteria 1TP9D@1239,4HA6D@91061,COG0215@1,COG0215@2 NA|NA|NA J Belongs to the class-I aminoacyl-tRNA synthetase family MIPOCGNA_00850 322159.STER_0118 2.7e-67 261.2 Bacilli mrnC GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 ko:K11145 ko00000,ko01000,ko03009 Bacteria 1VA5V@1239,4HIM3@91061,COG1939@1,COG1939@2 NA|NA|NA J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) MIPOCGNA_00853 264199.stu0088 2.4e-133 481.5 Bacilli trmH GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 ko:K03218,ko:K03437,ko:K12952 ko00000,ko01000,ko03009,ko03016 3.A.3.23 Bacteria 1TP9G@1239,4HBBI@91061,COG0566@1,COG0566@2 NA|NA|NA J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family MIPOCGNA_00854 264199.stu0089 4.6e-91 340.5 Bacilli yacP ko:K06962 ko00000 Bacteria 1V9XR@1239,4HFW4@91061,COG3688@1,COG3688@2 NA|NA|NA S RNA-binding protein containing a PIN domain MIPOCGNA_00855 264199.stu0090 2.8e-154 551.2 Bacilli degV Bacteria 1TQDI@1239,4HAYQ@91061,COG1307@1,COG1307@2 NA|NA|NA S DegV family MIPOCGNA_00856 411460.RUMTOR_00063 4.3e-20 104.4 Clostridia Bacteria 1VK84@1239,24UEE@186801,COG1396@1,COG1396@2 NA|NA|NA K helix-turn-helix MIPOCGNA_00857 264199.stu0092 3e-181 641.0 Bacilli panE 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 Bacteria 1TSZ1@1239,4HB4T@91061,COG1893@1,COG1893@2 NA|NA|NA H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid MIPOCGNA_00858 1046629.Ssal_02077 2e-79 301.6 Bacilli rplM GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0070180,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02871 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V3HX@1239,4HG0I@91061,COG0102@1,COG0102@2 NA|NA|NA J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly MIPOCGNA_00859 264199.stu0094 9.5e-65 252.7 Bacilli rpsI GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02996 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V3MQ@1239,4HH3B@91061,COG0103@1,COG0103@2 NA|NA|NA J Belongs to the universal ribosomal protein uS9 family MIPOCGNA_00860 1095738.HMPREF1047_1586 6.7e-210 736.5 Streptococcus oralis Bacteria 1UXIB@1239,1WQ8A@1303,4I3E7@91061,COG0582@1,COG0582@2 NA|NA|NA L Phage integrase family MIPOCGNA_00861 1005705.HMPREF9967_0077 1e-33 149.1 Streptococcus infantis Bacteria 1TVYW@1239,2BC4R@1,325PI@2,43GN2@68892,4I4M2@91061 NA|NA|NA S Helix-turn-helix domain MIPOCGNA_00862 1005705.HMPREF9967_0076 8.4e-97 359.8 Streptococcus infantis Bacteria 1TWIV@1239,29HG7@1,304DI@2,43GD1@68892,4I5CA@91061 NA|NA|NA S Plasmid replication protein MIPOCGNA_00863 1095738.HMPREF1047_1589 2.3e-65 255.4 Streptococcus oralis Bacteria 1TWYQ@1239,1WPXP@1303,2ERR9@1,304NZ@2,4I5TN@91061 NA|NA|NA MIPOCGNA_00864 1123300.AUIN01000021_gene767 1.2e-197 695.7 Bacilli Bacteria 1UZV0@1239,4HCE6@91061,COG1674@1,COG1674@2 NA|NA|NA D COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins MIPOCGNA_00865 1095738.HMPREF1047_1591 1.9e-47 194.9 Streptococcus oralis Bacteria 1TWYS@1239,1WPXV@1303,29QR3@1,30BQX@2,4I5TQ@91061 NA|NA|NA MIPOCGNA_00867 435842.HMPREF0848_01425 4.3e-181 641.0 Bacilli norB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 ko:K08170 M00702 ko00000,ko00002,ko01504,ko02000 2.A.1.3.23,2.A.1.3.59 Bacteria 1UKEJ@1239,4ITHT@91061,COG0477@1,COG0477@2 NA|NA|NA P Major Facilitator Superfamily MIPOCGNA_00868 435842.HMPREF0848_01424 3.8e-78 298.5 Bacilli Bacteria 1TQ0M@1239,4HA8M@91061,COG0604@1,COG0604@2 NA|NA|NA C nadph quinone reductase MIPOCGNA_00869 435842.HMPREF0848_01423 1.4e-37 162.5 Firmicutes Bacteria 1VG8M@1239,COG1959@1,COG1959@2 NA|NA|NA K Transcriptional regulator MIPOCGNA_00870 435842.HMPREF0848_01422 1.4e-68 266.2 Bacteria ko:K07025 ko00000 Bacteria COG0637@1,COG0637@2 NA|NA|NA S phosphonoacetaldehyde hydrolase activity MIPOCGNA_00871 435842.HMPREF0848_01421 1.7e-28 132.1 Bacteria pcaC 3.1.1.24,4.1.1.44 ko:K01055,ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00568 R02991,R03470 RC00825,RC00938 ko00000,ko00001,ko00002,ko01000 Bacteria COG0599@1,COG0599@2 NA|NA|NA S peroxiredoxin activity MIPOCGNA_00872 1203590.HMPREF1481_01138 6.5e-31 141.0 Bacilli ais Bacteria 1VDCB@1239,4HD4C@91061,COG0406@1,COG0406@2 NA|NA|NA G Phosphoglycerate mutase MIPOCGNA_00875 1229517.AMFD01000016_gene840 5.2e-53 213.4 Lactococcus tnp ko:K07498 ko00000 Bacteria 1TTKR@1239,1YB3Z@1357,4HCB4@91061,COG3316@1,COG3316@2 NA|NA|NA L Transposase IS66 family MIPOCGNA_00877 322159.STER_0729 3e-235 820.8 Bacilli mntH GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0042221,GO:0050896,GO:0051716,GO:0070887,GO:0071241,GO:0071248,GO:0071281 ko:K03322 ko00000,ko02000 2.A.55.2.6,2.A.55.3 Bacteria 1TPT1@1239,4HAEA@91061,COG1914@1,COG1914@2 NA|NA|NA P H( )-stimulated, divalent metal cation uptake system MIPOCGNA_00878 264199.stu0676 1.1e-33 148.7 Bacilli XK27_12190 Bacteria 1VEFE@1239,4HNSP@91061,COG4443@1,COG4443@2 NA|NA|NA S protein conserved in bacteria MIPOCGNA_00880 322159.STER_0726 2.1e-86 325.1 Bacilli bioY ko:K03523 ko02010,map02010 M00581,M00582 ko00000,ko00001,ko00002,ko02000 2.A.88.1,2.A.88.2 Bacteria 1VA1G@1239,4HNE8@91061,COG1268@1,COG1268@2 NA|NA|NA S biotin synthase MIPOCGNA_00881 322159.STER_0725 3.4e-252 877.1 Bacilli yegQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K08303 ko05120,map05120 ko00000,ko00001,ko01000,ko01002 Bacteria 1TPRE@1239,4HBEG@91061,COG0826@1,COG0826@2 NA|NA|NA O Peptidase U32 MIPOCGNA_00882 264199.stu0671 1.7e-176 625.2 Bacilli yegQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K08303 ko05120,map05120 ko00000,ko00001,ko01000,ko01002 Bacteria 1TQIZ@1239,4HA2T@91061,COG0826@1,COG0826@2 NA|NA|NA O Peptidase U32 MIPOCGNA_00884 322159.STER_0722 1.2e-68 265.8 Bacilli ytxH Bacteria 1VFY7@1239,4HNWV@91061,COG4980@1,COG4980@2 NA|NA|NA S General stress protein MIPOCGNA_00886 264199.stu0667 3.1e-147 527.7 Bacilli lgt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009058,GO:0009059,GO:0009898,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0040007,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0140096,GO:1901564,GO:1901566,GO:1901576 2.1.1.199 ko:K03438,ko:K13292 ko00000,ko01000,ko03009 Bacteria 1TPAK@1239,4HAT0@91061,COG0682@1,COG0682@2 NA|NA|NA M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins MIPOCGNA_00887 322159.STER_0719 4.9e-168 597.0 Bacilli hprK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K06023 ko00000,ko01000 Bacteria 1TP5Z@1239,4HAXR@91061,COG1493@1,COG1493@2 NA|NA|NA F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion MIPOCGNA_00888 264199.stu0665 6.4e-41 172.9 Bacilli pspC ko:K03973 ko00000,ko02048,ko03000 Bacteria 1VF0M@1239,4IRAN@91061,COG1983@1,COG1983@2 NA|NA|NA KT PspC domain MIPOCGNA_00889 322159.STER_0716 0.0 1342.4 Bacilli yhgF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0044424,GO:0044444,GO:0044464,GO:0050896 ko:K06959 ko00000 Bacteria 1TPFE@1239,4HAGY@91061,COG2183@1,COG2183@2 NA|NA|NA K Transcriptional accessory protein MIPOCGNA_00891 322159.STER_0714 1.6e-155 555.4 Bacilli XK27_03015 ko:K07089 ko00000 Bacteria 1TQHK@1239,4HB25@91061,COG0701@1,COG0701@2 NA|NA|NA S permease MIPOCGNA_00892 264199.stu0661 3.5e-146 524.2 Bacilli ycgQ ko:K08986 ko00000 Bacteria 1V3EX@1239,4HGMG@91061,COG3689@1,COG3689@2 NA|NA|NA S TIGR03943 family MIPOCGNA_00893 322159.STER_0712 5.9e-186 656.8 Firmicutes Bacteria 1W43F@1239,2DZ2B@1,34C6V@2 NA|NA|NA S CRISPR-associated protein Csn2 subfamily St MIPOCGNA_00894 264199.stu0659 3.1e-53 214.2 Bacilli cas2 ko:K09951 ko00000,ko02048 Bacteria 1VEH4@1239,4HNYR@91061,COG3512@1,COG3512@2 NA|NA|NA L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette MIPOCGNA_00895 322159.STER_0710 5.5e-172 610.1 Bacilli cas1 ko:K15342 ko00000,ko02048,ko03400 Bacteria 1TT0J@1239,4HC5E@91061,COG1518@1,COG1518@2 NA|NA|NA L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette MIPOCGNA_00896 322159.STER_0709 0.0 2046.9 Bacilli cas9 ko:K09952 ko00000,ko01000,ko02048 Bacteria 1TPSD@1239,4HE0R@91061,COG3513@1,COG3513@2 NA|NA|NA L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer MIPOCGNA_00897 1046629.Ssal_01451 2.1e-95 355.1 Firmicutes Bacteria 1VYAW@1239,2F636@1,33YMH@2 NA|NA|NA MIPOCGNA_00898 1046629.Ssal_01453 1.9e-27 127.9 Bacilli estA Bacteria 1V1CQ@1239,4HGVZ@91061,COG2755@1,COG2755@2 NA|NA|NA E GDSL-like Lipase/Acylhydrolase MIPOCGNA_00899 1046629.Ssal_01454 1e-30 139.0 Bacilli Bacteria 1VBYM@1239,4HM2K@91061,COG1266@1,COG1266@2 NA|NA|NA S CAAX protease self-immunity MIPOCGNA_00900 1046629.Ssal_01454 1.7e-26 124.8 Bacilli Bacteria 1VBYM@1239,4HM2K@91061,COG1266@1,COG1266@2 NA|NA|NA S CAAX protease self-immunity MIPOCGNA_00901 1046629.Ssal_01455 2.4e-33 147.5 Firmicutes Bacteria 1VZAT@1239,2FBVV@1,3440F@2 NA|NA|NA MIPOCGNA_00903 1046629.Ssal_01457 3.3e-64 250.8 Bacilli yqeB Bacteria 1V717@1239,2AK1X@1,31ARI@2,4HIQ9@91061 NA|NA|NA S Pyrimidine dimer DNA glycosylase MIPOCGNA_00904 435842.HMPREF0848_00317 7.8e-59 233.0 Bacilli ko:K13281 ko00000,ko01000 Bacteria 1VGGK@1239,4HP7S@91061,COG3272@1,COG3272@2 NA|NA|NA S Protein of unknown function (DUF1722) MIPOCGNA_00905 585203.SMSK564_1364 8.9e-11 72.4 Streptococcus mitis Bacteria 1U4XP@1239,2DKGP@1,2TQDW@28037,309EM@2,4IEP2@91061 NA|NA|NA MIPOCGNA_00906 264199.stu1512 1e-156 559.7 Bacilli ko:K06871 ko00000 Bacteria 1TQPS@1239,4HCKJ@91061,COG0641@1,COG0641@2 NA|NA|NA C Arylsulfatase regulator (Fe-S oxidoreductase) MIPOCGNA_00907 467705.SGO_1358 1.4e-44 186.0 Bacteria ko:K06147,ko:K06148 ko00000,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.21 Bacteria COG1132@1,COG1132@2 NA|NA|NA V (ABC) transporter MIPOCGNA_00908 467705.SGO_1358 5.6e-133 480.7 Bacteria ko:K06147,ko:K06148 ko00000,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.21 Bacteria COG1132@1,COG1132@2 NA|NA|NA V (ABC) transporter MIPOCGNA_00909 1046629.Ssal_00659 1.4e-50 205.3 Bacilli 2.3.1.128 ko:K03789 ko00000,ko01000,ko03009 Bacteria 1VEW7@1239,4HPE4@91061,COG0454@1,COG0456@2 NA|NA|NA K Acetyltransferase GNAT Family MIPOCGNA_00910 1046629.Ssal_00660 1.4e-273 948.3 Bacilli Bacteria 1VBKU@1239,2DI63@1,32UAI@2,4HUJH@91061 NA|NA|NA S Protein of unknown function (DUF3114) MIPOCGNA_00912 264199.stu1413 0.0 1508.0 Bacilli gshF 6.3.2.2,6.3.2.29,6.3.2.30,6.3.2.4 ko:K01919,ko:K01921,ko:K03802,ko:K16786,ko:K16787 ko00270,ko00473,ko00480,ko00550,ko01100,ko01502,ko02010,map00270,map00473,map00480,map00550,map01100,map01502,map02010 M00118,M00582 R00894,R01150,R10993 RC00064,RC00090,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 Bacteria 1TPGX@1239,4HAMJ@91061,COG1181@1,COG1181@2,COG2918@1,COG2918@2 NA|NA|NA H Belongs to the glutamate--cysteine ligase type 1 family MIPOCGNA_00913 264199.stu1412 2.1e-39 167.9 Bacteria ko:K18996,ko:K19171 ko00000,ko02048,ko03032 Bacteria COG1132@1,COG1132@2 NA|NA|NA V (ABC) transporter MIPOCGNA_00914 904306.HMPREF9192_0999 6.5e-102 376.7 Bacilli ko:K06147 ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 1TP0B@1239,4HA3S@91061,COG1132@1,COG1132@2 NA|NA|NA V abc transporter atp-binding protein MIPOCGNA_00915 904306.HMPREF9192_1001 8.1e-258 896.0 Bacilli zmpB GO:0005575,GO:0005618,GO:0005623,GO:0009986,GO:0016020,GO:0030312,GO:0044464,GO:0071944 ko:K08643 ko00000,ko01000,ko01002 Bacteria 1UJ29@1239,4IT10@91061,COG3064@1,COG3064@2 NA|NA|NA M M26 IgA1-specific Metallo-endopeptidase C-terminal region MIPOCGNA_00916 264199.stu1405 6.7e-24 115.9 Bacteria ko:K07497 ko00000 Bacteria COG2801@1,COG2801@2 NA|NA|NA L transposition MIPOCGNA_00917 264199.stu0038 1.2e-08 64.3 Firmicutes ko:K07497 ko00000 Bacteria 1TQQY@1239,COG2801@1,COG2801@2 NA|NA|NA L Integrase core domain protein MIPOCGNA_00918 264199.stu1403 1.3e-182 645.6 Bacilli galR ko:K02529 ko00000,ko03000 Bacteria 1TPZJ@1239,4HC9Z@91061,COG1609@1,COG1609@2 NA|NA|NA K Transcriptional regulator MIPOCGNA_00919 322159.STER_1371 1.1e-220 772.3 Bacilli galK GO:0005975,GO:0005996,GO:0006012,GO:0008150,GO:0008152,GO:0019318,GO:0044238,GO:0044281,GO:0071704 2.7.1.6 ko:K00849 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00554,M00632 R01092 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1TPD0@1239,4HARP@91061,COG0153@1,COG0153@2 NA|NA|NA G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) MIPOCGNA_00920 264199.stu1401 5.4e-286 989.6 Bacilli galT 2.7.7.12 ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 M00362,M00554,M00632 R00955 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPBN@1239,4HAYJ@91061,COG4468@1,COG4468@2 NA|NA|NA G UDPglucose--hexose-1-phosphate uridylyltransferase MIPOCGNA_00921 322159.STER_1369 2.1e-193 681.4 Bacilli galE 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQ7N@1239,4H9U5@91061,COG1087@1,COG1087@2 NA|NA|NA M Belongs to the NAD(P)-dependent epimerase dehydratase family MIPOCGNA_00922 264199.stu1399 8.7e-198 696.0 Bacilli galM 5.1.3.3 ko:K01785 ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130 M00632 R01602,R10619 RC00563 ko00000,ko00001,ko00002,ko01000 Bacteria 1V5UK@1239,4HTRY@91061,COG2017@1,COG2017@2 NA|NA|NA G Catalyzes the interconversion of alpha and beta anomers of maltose MIPOCGNA_00923 322159.STER_1367 0.0 1183.3 Bacilli lacS GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03292,ko:K11104,ko:K16209 ko00000,ko02000 2.A.2,2.A.2.1,2.A.2.2 Bacteria 1TRA5@1239,4HCDS@91061,COG2190@1,COG2190@2,COG2211@1,COG2211@2 NA|NA|NA G transporter MIPOCGNA_00924 264199.stu1397 0.0 2109.7 Bacilli lacL 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 Bacteria 1TPDC@1239,4HANW@91061,COG3250@1,COG3250@2 NA|NA|NA G -beta-galactosidase MIPOCGNA_00926 264199.stu1978 1.7e-23 114.8 Bacteria yegS GO:0001727,GO:0003674,GO:0003824,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0030258,GO:0044237,GO:0044238,GO:0044255,GO:0046834,GO:0071704 2.7.1.107 ko:K07029 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 R02240 RC00002,RC00017 ko00000,ko00001,ko01000 Bacteria COG1597@1,COG1597@2 NA|NA|NA I lipid kinase activity MIPOCGNA_00929 1046629.Ssal_00051 6.7e-19 99.0 Bacteria rpmG GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046677,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02913 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria COG0267@1,COG0267@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL33 family MIPOCGNA_00930 1123315.AUIP01000010_gene919 2e-25 120.9 Bacilli rpmF GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904 ko:K02911 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011,ko03029 Bacteria 1VKMZ@1239,4HR2Q@91061,COG0333@1,COG0333@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL32 family MIPOCGNA_00931 1046629.Ssal_00053 9.2e-36 155.6 Bacilli metE 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPDQ@1239,4HADW@91061,COG0620@1,COG0620@2 NA|NA|NA E Methionine synthase MIPOCGNA_00932 1046629.Ssal_00053 7.6e-64 249.6 Bacilli metE 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPDQ@1239,4HADW@91061,COG0620@1,COG0620@2 NA|NA|NA E Methionine synthase MIPOCGNA_00933 1046629.Ssal_00053 5.7e-52 209.9 Bacilli metE 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPDQ@1239,4HADW@91061,COG0620@1,COG0620@2 NA|NA|NA E Methionine synthase MIPOCGNA_00934 322159.STER_1950 1.6e-241 841.6 Bacilli hisS 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1TP3D@1239,4HAM2@91061,COG0124@1,COG0124@2 NA|NA|NA J histidyl-tRNA synthetase MIPOCGNA_00936 322159.STER_1948 0.0 1142.1 Bacilli aspS 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Bacteria 1TPCN@1239,4HACD@91061,COG0173@1,COG0173@2 NA|NA|NA J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) MIPOCGNA_00937 322159.STER_1947 9.9e-169 599.4 Bacilli XK27_01785 Bacteria 1TRBT@1239,4HBPR@91061,COG1284@1,COG1284@2 NA|NA|NA S cog cog1284 MIPOCGNA_00938 322159.STER_1946 7e-147 526.6 Bacilli yaaA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0033194,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:1901700 ko:K09861 ko00000 Bacteria 1TR33@1239,4HFN2@91061,COG3022@1,COG3022@2 NA|NA|NA S Belongs to the UPF0246 family MIPOCGNA_00939 264199.stu1966 2.8e-116 424.5 Bacilli nrdG GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008998,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0015949,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0019692,GO:0031250,GO:0032991,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046385,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901576 1.97.1.4 ko:K04068 R04710 ko00000,ko01000 iE2348C_1286.E2348C_4563 Bacteria 1V1HG@1239,4HGJ9@91061,COG0602@1,COG0602@2 NA|NA|NA O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine MIPOCGNA_00940 264199.stu1965 9.9e-91 339.3 Bacilli XK27_10930 Bacteria 1V1C4@1239,4HG6C@91061,COG3981@1,COG3981@2 NA|NA|NA K acetyltransferase MIPOCGNA_00941 435842.HMPREF0848_01736 7.5e-14 82.0 Bacilli Bacteria 1TXD1@1239,2DEKJ@1,2ZNBP@2,4HZYT@91061 NA|NA|NA MIPOCGNA_00942 322159.STER_1942 0.0 1501.5 Bacilli nrdD GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008998,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0015949,GO:0016491,GO:0016725,GO:0016728,GO:0017076,GO:0018130,GO:0019001,GO:0019103,GO:0019438,GO:0019637,GO:0019692,GO:0030554,GO:0031250,GO:0032552,GO:0032553,GO:0032554,GO:0032555,GO:0032556,GO:0032558,GO:0032559,GO:0032560,GO:0032564,GO:0032567,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046385,GO:0046483,GO:0046872,GO:0046914,GO:0051065,GO:0055086,GO:0055114,GO:0071704,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576 1.1.98.6 ko:K21636 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R11633,R11634,R11635,R11636 RC00613 ko00000,ko00001,ko00002,ko01000 iECIAI39_1322.ECIAI39_4713,iPC815.YPO3454 Bacteria 1TR9K@1239,4HBIY@91061,COG1327@1,COG1327@2,COG1328@1,COG1328@2 NA|NA|NA F Ribonucleoside-triphosphate reductase MIPOCGNA_00943 264199.stu1962 1.7e-285 988.0 Bacilli ccs Bacteria 1V9D8@1239,2F2IJ@1,33VFI@2,4HS77@91061 NA|NA|NA S the current gene model (or a revised gene model) may contain a frame shift MIPOCGNA_00944 322159.STER_1939 4.2e-44 183.7 Bacilli yrzB Bacteria 1VAPW@1239,4HKV7@91061,COG3906@1,COG3906@2 NA|NA|NA S Belongs to the UPF0473 family MIPOCGNA_00945 264199.stu1960 1.2e-70 272.3 Bacilli yqgF GO:0000966,GO:0000967,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360 ko:K07447 ko00000,ko01000 Bacteria 1V6ER@1239,4HH04@91061,COG0816@1,COG0816@2 NA|NA|NA L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA MIPOCGNA_00946 264199.stu1959 2.2e-44 184.5 Bacilli yrzL Bacteria 1VAC4@1239,4HKD0@91061,COG4472@1,COG4472@2 NA|NA|NA S Belongs to the UPF0297 family MIPOCGNA_00947 264199.stu1958 5.5e-26 122.9 Bacilli rpmB GO:0003674,GO:0003735,GO:0005198 ko:K02902 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1VEI2@1239,4HNIK@91061,COG0227@1,COG0227@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL28 family MIPOCGNA_00948 264199.stu1957 1.1e-236 825.5 Bacilli rarA ko:K07478 ko00000 Bacteria 1TPVV@1239,4HAIS@91061,COG2256@1,COG2256@2 NA|NA|NA L ATPase related to the helicase subunit of the Holliday junction resolvase MIPOCGNA_00950 264199.stu1949 2.1e-280 971.1 Bacilli ko:K06147,ko:K06148 ko00000,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 1TSRV@1239,4HCIZ@91061,COG1132@1,COG1132@2 NA|NA|NA V ABC transporter MIPOCGNA_00951 322159.STER_1920 0.0 1377.1 Bacilli Bacteria 1V7E2@1239,4HJ1U@91061,COG0515@1,COG0515@2 NA|NA|NA KLT serine threonine protein kinase MIPOCGNA_00952 322159.STER_1919 3.4e-155 554.3 Bacilli Z012_04635 ko:K20373 ko02024,map02024 ko00000,ko00001,ko03000 Bacteria 1UZI0@1239,4HC2C@91061,COG1396@1,COG1396@2 NA|NA|NA K Transcriptional activator, Rgg GadR MutR family MIPOCGNA_00954 264199.stu0061 2.3e-66 258.1 Bacilli spxA_2 1.20.4.1 ko:K00537,ko:K16509 ko00000,ko01000 Bacteria 1VYBB@1239,4HWYC@91061,COG1393@1,COG1393@2 NA|NA|NA P Belongs to the ArsC family MIPOCGNA_00955 322159.STER_0077 1e-204 719.2 Bacilli recA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009292,GO:0009294,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030420,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0046483,GO:0050896,GO:0051704,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360 ko:K03553 ko03440,map03440 M00729 ko00000,ko00001,ko00002,ko03400 Bacteria 1TPD5@1239,4HAG5@91061,COG0468@1,COG0468@2 NA|NA|NA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage MIPOCGNA_00956 322159.STER_0076 2.9e-232 810.8 Bacilli cinA GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363 3.5.1.42 ko:K03742,ko:K03743 ko00760,map00760 R02322 RC00100 ko00000,ko00001,ko01000 Bacteria 1TQ1N@1239,4HATN@91061,COG1058@1,COG1058@2,COG1546@1,COG1546@2 NA|NA|NA S Belongs to the CinA family MIPOCGNA_00957 322159.STER_0075 1.9e-106 391.7 Bacilli tag 3.2.2.20 ko:K01246 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 1V9B8@1239,4HJ4I@91061,COG2818@1,COG2818@2 NA|NA|NA L 3-methyladenine DNA glycosylase MIPOCGNA_00958 322159.STER_0074 7.8e-103 379.8 Bacilli ruvA GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 ko:K03550 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 1V3KF@1239,4HHI5@91061,COG0632@1,COG0632@2 NA|NA|NA L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB MIPOCGNA_00960 322159.STER_0072 0.0 1251.1 Bacilli mutL GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0032300,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1990391 ko:K03572 ko03430,map03430 ko00000,ko00001,ko03400 Bacteria 1TPGK@1239,4HB34@91061,COG0323@1,COG0323@2 NA|NA|NA L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex MIPOCGNA_00962 904306.HMPREF9192_0027 5.4e-69 266.9 Bacilli Bacteria 1VE2H@1239,4IPMG@91061,COG3279@1,COG3279@2 NA|NA|NA K LytTr DNA-binding domain MIPOCGNA_00963 1046629.Ssal_02119 2.3e-78 298.1 Bacilli Bacteria 1VHBQ@1239,2E0UI@1,32WBZ@2,4HRYH@91061 NA|NA|NA S Protein of unknown function (DUF3021) MIPOCGNA_00964 322159.STER_0068 0.0 1630.9 Bacilli mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 ko:K03555 ko03430,map03430 ko00000,ko00001,ko03400 Bacteria 1TPRJ@1239,4HA63@91061,COG0249@1,COG0249@2 NA|NA|NA L that it carries out the mismatch recognition step. This protein has a weak ATPase activity MIPOCGNA_00965 264199.stu0049 1e-57 229.2 Bacilli ymcA 3.6.3.21 ko:K02028 M00236 ko00000,ko00002,ko01000,ko02000 3.A.1.3 Bacteria 1V4W0@1239,4HH6Y@91061,COG4550@1,COG4550@2 NA|NA|NA S Belongs to the UPF0342 family MIPOCGNA_00966 264199.stu0048 8.2e-70 269.6 Bacilli argR GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 ko:K03402 ko00000,ko03000 Bacteria 1V1R7@1239,4HFY8@91061,COG1438@1,COG1438@2 NA|NA|NA K Regulates arginine biosynthesis genes MIPOCGNA_00967 322159.STER_0065 0.0 1110.5 Bacilli argS 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Bacteria 1TPEZ@1239,4HAR3@91061,COG0018@1,COG0018@2 NA|NA|NA J Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA MIPOCGNA_00968 264199.stu0045 8.7e-248 862.4 Bacilli purB GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 iLJ478.TM1095,iSB619.SA_RS09895 Bacteria 1TPMM@1239,4HACW@91061,COG0015@1,COG0015@2 NA|NA|NA F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily MIPOCGNA_00969 904306.HMPREF9192_0018 6.6e-34 149.4 Bacilli Bacteria 1VIUY@1239,2DZH9@1,32VAR@2,4HZSZ@91061 NA|NA|NA MIPOCGNA_00970 264199.stu0043 5.6e-86 323.6 Firmicutes 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 Bacteria 1UD8U@1239,COG1893@1,COG1893@2 NA|NA|NA H Ketopantoate reductase MIPOCGNA_00971 264199.stu0043 9.3e-46 189.1 Firmicutes 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 Bacteria 1UD8U@1239,COG1893@1,COG1893@2 NA|NA|NA H Ketopantoate reductase MIPOCGNA_00972 264199.stu0042 1.9e-203 714.9 Bacilli purK 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQCD@1239,4H9M5@91061,COG0026@1,COG0026@2 NA|NA|NA F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) MIPOCGNA_00973 322159.STER_0059 3.8e-70 270.8 Bacilli purE GO:0003674,GO:0003824,GO:0004638,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0016853,GO:0016866,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034023,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 iETEC_1333.ETEC_0575,iJN746.PP_5336,iPC815.YPO3076,iUTI89_1310.UTI89_C0551 Bacteria 1V1MV@1239,4HFR7@91061,COG0041@1,COG0041@2 NA|NA|NA F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) MIPOCGNA_00974 264199.stu0040 2e-241 841.3 Bacilli purD 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS05245,iYO844.BSU06530 Bacteria 1UHN9@1239,4HA70@91061,COG0151@1,COG0151@2 NA|NA|NA F Belongs to the GARS family MIPOCGNA_00975 264199.stu0039 7.5e-160 569.7 Bacilli ko:K21471 ko00000,ko01000,ko01002,ko01011 Bacteria 1VUNU@1239,4HVY0@91061,COG3942@1,COG3942@2 NA|NA|NA S CHAP domain MIPOCGNA_00976 1161413.HMPREF1510_1836 1.5e-30 138.3 Firmicutes ko:K07497 ko00000 Bacteria 1TQQY@1239,COG2801@1,COG2801@2 NA|NA|NA L Integrase core domain protein MIPOCGNA_00977 1316408.HSISM1_519 2.7e-116 424.9 Bacilli ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TPHU@1239,4HA2C@91061,COG0577@1,COG0577@2 NA|NA|NA V ABC transporter (Permease MIPOCGNA_00978 999425.HMPREF9186_00913 4.1e-114 417.5 Bacilli Bacteria 1TRQB@1239,4HAY3@91061,COG1028@1,COG1028@2 NA|NA|NA IQ Belongs to the short-chain dehydrogenases reductases (SDR) family MIPOCGNA_00979 888746.HMPREF9180_1259 1.6e-10 71.6 Bacilli Bacteria 1W4NX@1239,2DD3F@1,2ZGBB@2,4I0KR@91061 NA|NA|NA MIPOCGNA_00980 322159.STER_0946 1.2e-97 362.5 Bacilli Bacteria 1TSUJ@1239,4IPZN@91061,COG1309@1,COG1309@2 NA|NA|NA K Transcriptional regulator, TetR family MIPOCGNA_00981 322159.STER_0947 1.8e-159 568.5 Bacilli czcD ko:K16264 ko00000,ko02000 2.A.4.1 Bacteria 1TR92@1239,4HBCQ@91061,COG1230@1,COG1230@2 NA|NA|NA P cation diffusion facilitator family transporter MIPOCGNA_00982 264199.stu0934 1.5e-52 211.8 Bacilli hemH GO:0003674,GO:0003824,GO:0004325,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPKF@1239,4HAYG@91061,COG0276@1,COG0276@2 NA|NA|NA H Catalyzes the ferrous insertion into protoporphyrin IX MIPOCGNA_00983 322159.STER_0948 6.7e-144 516.5 Bacilli hemH GO:0003674,GO:0003824,GO:0004325,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPKF@1239,4HAYG@91061,COG0276@1,COG0276@2 NA|NA|NA H Catalyzes the ferrous insertion into protoporphyrin IX MIPOCGNA_00984 322159.STER_0949 2.3e-195 688.0 Bacilli adhB 1.1.1.1,1.1.1.14 ko:K00001,ko:K00008 ko00010,ko00040,ko00051,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00040,map00051,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 M00014 R00623,R00754,R00875,R01896,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00085,RC00087,RC00088,RC00099,RC00102,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPIW@1239,4HB2G@91061,COG1063@1,COG1063@2 NA|NA|NA E Dehydrogenase MIPOCGNA_00985 1046629.Ssal_01058 2.3e-07 60.1 Bacilli ko:K06889 ko00000 Bacteria 1TPW7@1239,4HEFQ@91061,COG1073@1,COG1073@2 NA|NA|NA S Hydrolases of the alpha beta superfamily MIPOCGNA_00986 264199.stu0937 7.9e-17 92.0 Bacteria Bacteria COG4814@1,COG4814@2 NA|NA|NA S Alpha/beta hydrolase of unknown function (DUF915) MIPOCGNA_00987 264199.stu0938 1.2e-79 302.4 Bacteria Bacteria COG4814@1,COG4814@2 NA|NA|NA S Alpha/beta hydrolase of unknown function (DUF915) MIPOCGNA_00990 322159.STER_0955 1.2e-143 515.8 Bacilli 2.4.2.3 ko:K00757 ko00240,ko00983,ko01100,map00240,map00983,map01100 R01876,R02484,R08229 RC00063 ko00000,ko00001,ko01000 Bacteria 1TQ71@1239,4HUI7@91061,COG2820@1,COG2820@2 NA|NA|NA F Phosphorylase superfamily MIPOCGNA_00991 322159.STER_0956 1.2e-117 429.1 Bacilli gph 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 R01334 RC00017 ko00000,ko00001,ko01000 Bacteria 1TPPZ@1239,4IPIP@91061,COG0546@1,COG0546@2 NA|NA|NA S HAD hydrolase, family IA, variant 1 MIPOCGNA_00992 1046629.Ssal_01070 9.4e-15 85.1 Bacilli yclQ ko:K02016 ko02010,map02010 M00240 ko00000,ko00001,ko00002,ko02000 3.A.1.14 Bacteria 1UXCZ@1239,4HAMP@91061,COG4607@1,COG4607@2 NA|NA|NA P ABC-type enterochelin transport system, periplasmic component MIPOCGNA_00993 1046629.Ssal_01070 3.3e-19 100.9 Bacilli yclQ ko:K02016 ko02010,map02010 M00240 ko00000,ko00001,ko00002,ko02000 3.A.1.14 Bacteria 1UXCZ@1239,4HAMP@91061,COG4607@1,COG4607@2 NA|NA|NA P ABC-type enterochelin transport system, periplasmic component MIPOCGNA_00994 904306.HMPREF9192_1770 3.9e-15 86.7 Bacilli dinF Bacteria 1TNZN@1239,4HANM@91061,COG0534@1,COG0534@2 NA|NA|NA V Mate efflux family protein MIPOCGNA_00996 264199.stu0950 1.1e-308 1065.1 Bacilli FbpA ko:K12341 ko03070,map03070 ko00000,ko00001,ko02044 1.B.40.1.1 Bacteria 1TQ8A@1239,4H9UF@91061,COG1293@1,COG1293@2 NA|NA|NA K RNA-binding protein homologous to eukaryotic snRNP MIPOCGNA_00998 904306.HMPREF9192_1767 1.8e-80 305.4 Bacilli Bacteria 1V7WE@1239,2B4EH@1,31X62@2,4HJ8G@91061 NA|NA|NA S TraX protein MIPOCGNA_00999 264199.stu0953 5e-96 357.1 Bacilli thiJ 2.7.11.1,3.5.1.124 ko:K03152,ko:K05520,ko:K12132 ko00000,ko01000,ko01001,ko01002 Bacteria 1V3WB@1239,4HM36@91061,COG0693@1,COG0693@2 NA|NA|NA S DJ-1 family MIPOCGNA_01000 264199.stu0954 4.8e-148 530.4 Bacilli pyrK GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0016645,GO:0016646,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042602,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0052875,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 ko:K02823 ko00240,ko01100,map00240,map01100 ko00000,ko00001 iYO844.BSU15530 Bacteria 1TQ5D@1239,4HAU4@91061,COG0543@1,COG0543@2 NA|NA|NA C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) MIPOCGNA_01001 1046629.Ssal_01079 1.9e-175 621.7 Bacilli pyrD GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.98.1 ko:K00226,ko:K02823,ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01867,R01869 RC00051 ko00000,ko00001,ko00002,ko01000 iYO844.BSU15540 Bacteria 1TPFV@1239,4HA5H@91061,COG0167@1,COG0167@2 NA|NA|NA F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily MIPOCGNA_01002 264199.stu0967 9.1e-127 459.5 Bacilli pyrF GO:0003674,GO:0003824,GO:0004590,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 iECO103_1326.ECO103_1444,iECSF_1327.ECSF_1264,iSFV_1184.SFV_1294,iSF_1195.SF1285,iSFxv_1172.SFxv_1457,iS_1188.S1368,ic_1306.c1750 Bacteria 1TPPH@1239,4HAJ2@91061,COG0284@1,COG0284@2 NA|NA|NA F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) MIPOCGNA_01003 322159.STER_0981 7.5e-112 409.8 Bacilli pyrE 2.4.2.10,4.1.1.23 ko:K00762,ko:K01591,ko:K13421 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00051 R00965,R01870,R08231 RC00063,RC00409,RC00611 ko00000,ko00001,ko00002,ko01000 iYO844.BSU15560 Bacteria 1V1BZ@1239,4HFV7@91061,COG0461@1,COG0461@2 NA|NA|NA F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) MIPOCGNA_01004 1046629.Ssal_01082 7.1e-18 95.9 Bacteria nylA 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 Bacteria COG0154@1,COG0154@2 NA|NA|NA J amidase activity MIPOCGNA_01005 1069533.Sinf_0729 4.1e-195 687.2 Bacilli wbbI GO:0003674,GO:0003824,GO:0008194,GO:0008378,GO:0008921,GO:0016740,GO:0016757,GO:0016758,GO:0035250 iAF1260.b2034,iBWG_1329.BWG_1824,iECDH10B_1368.ECDH10B_2184,iECDH1ME8569_1439.ECDH1ME8569_1971,iECSF_1327.ECSF_1923,iEcDH1_1363.EcDH1_1623,iJO1366.b2034,iY75_1357.Y75_RS10645 Bacteria 1UZFG@1239,4ISTK@91061,COG0438@1,COG0438@2 NA|NA|NA M transferase activity, transferring glycosyl groups MIPOCGNA_01006 1069533.Sinf_0728 2.1e-57 228.0 Bacilli sacB ko:K20444 ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 Bacteria 1TPG9@1239,4HGEP@91061,COG0438@1,COG0438@2 NA|NA|NA M Stealth protein CR2, conserved region 2 MIPOCGNA_01007 888048.HMPREF8577_1411 5.4e-68 263.5 Bacilli sacB ko:K20444 ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 Bacteria 1TPG9@1239,4HGEP@91061,COG0438@1,COG0438@2 NA|NA|NA M Stealth protein CR2, conserved region 2 MIPOCGNA_01008 1069533.Sinf_0727 4.8e-215 753.4 Bacilli glf GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008767,GO:0009273,GO:0009987,GO:0016020,GO:0016853,GO:0016866,GO:0030312,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0071554,GO:0071766,GO:0071840,GO:0071944,GO:0097159,GO:1901265,GO:1901363 5.4.99.9 ko:K01854 ko00052,ko00520,map00052,map00520 R00505,R09009 RC00317,RC02396 ko00000,ko00001,ko01000 iNJ661.Rv3809c Bacteria 1TQB9@1239,4HB5F@91061,COG0562@1,COG0562@2 NA|NA|NA M UDP-galactopyranose mutase MIPOCGNA_01009 904306.HMPREF9192_1685 2e-242 844.7 Bacilli epsU Bacteria 1TP7R@1239,4HC84@91061,COG2244@1,COG2244@2 NA|NA|NA S Polysaccharide biosynthesis protein MIPOCGNA_01010 1069533.Sinf_0724 7.1e-86 323.2 Bacilli cpsB 3.1.3.48 ko:K01104 ko00000,ko01000 Bacteria 1TQ1T@1239,4HDZR@91061,COG4464@1,COG4464@2 NA|NA|NA GM Capsular polysaccharide biosynthesis protein MIPOCGNA_01012 1069533.Sinf_0722 1e-168 599.4 Bacilli Bacteria 1V0TF@1239,4ISVG@91061,COG1215@1,COG1215@2 NA|NA|NA M Glycosyltransferase, group 2 family protein MIPOCGNA_01013 1122146.AUHP01000009_gene708 9.2e-60 237.3 Lactobacillaceae ycbI Bacteria 1V8T1@1239,3F7RK@33958,4ISGC@91061,COG0463@1,COG0463@2 NA|NA|NA M Glycosyl transferase family 2 MIPOCGNA_01014 1122146.AUHP01000009_gene707 1.1e-17 97.8 Firmicutes Bacteria 1W0PQ@1239,2CKJG@1,34BHH@2 NA|NA|NA MIPOCGNA_01015 1069533.Sinf_0718 3.9e-96 357.8 Bacilli Bacteria 1V3YG@1239,4HG22@91061,COG3774@1,COG3774@2 NA|NA|NA M Glycosyltransferase sugar-binding region containing DXD motif MIPOCGNA_01016 264199.stu1104 1.4e-70 272.3 Bacilli pssE Bacteria 1VBCS@1239,4HIY5@91061,COG5017@1,COG5017@2 NA|NA|NA S Glycosyltransferase family 28 C-terminal domain MIPOCGNA_01017 264199.stu1105 4.6e-79 300.4 Bacilli cpsF Bacteria 1V91X@1239,4IPX3@91061,COG0707@1,COG0707@2 NA|NA|NA M Oligosaccharide biosynthesis protein Alg14 like MIPOCGNA_01018 1214166.ALLG01000019_gene1063 3.4e-83 314.3 Streptococcus suis cpsE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 1TP7M@1239,1WSUX@1307,4HCBG@91061,COG2148@1,COG2148@2 NA|NA|NA M Bacterial sugar transferase MIPOCGNA_01019 1214166.ALLG01000019_gene1063 1.2e-84 319.3 Streptococcus suis cpsE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 1TP7M@1239,1WSUX@1307,4HCBG@91061,COG2148@1,COG2148@2 NA|NA|NA M Bacterial sugar transferase MIPOCGNA_01020 904306.HMPREF9192_1679 2.2e-23 114.4 Bacilli rgpAc ko:K12996 ko00000,ko01000,ko01003,ko01005 GT4 Bacteria 1TR0Y@1239,4IPU2@91061,COG0438@1,COG0438@2 NA|NA|NA M group 1 family protein MIPOCGNA_01021 264199.stu1108 8.8e-251 872.5 Bacilli cpsE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 1TP7M@1239,4HB3Z@91061,COG2148@1,COG2148@2 NA|NA|NA M Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase MIPOCGNA_01022 322159.STER_1068 2.4e-112 411.8 Bacilli cpsD Bacteria 1TS4R@1239,4HCEN@91061,COG0489@1,COG0489@2 NA|NA|NA D COG0489 ATPases involved in chromosome partitioning MIPOCGNA_01023 1046629.Ssal_01180 1e-101 376.3 Bacilli cps4C Bacteria 1UZCR@1239,4HE26@91061,COG3944@1,COG3944@2 NA|NA|NA M biosynthesis protein MIPOCGNA_01024 264199.stu1111 1.1e-135 489.2 Bacilli cpsB 3.1.3.48 ko:K01104 ko00000,ko01000 Bacteria 1TQ1T@1239,4HDZR@91061,COG4464@1,COG4464@2 NA|NA|NA GM Capsular polysaccharide biosynthesis protein MIPOCGNA_01025 322159.STER_1071 1.3e-252 878.6 Bacilli cps4A Bacteria 1TR1B@1239,4HDRS@91061,COG1316@1,COG1316@2 NA|NA|NA K Cell envelope-like function transcriptional attenuator common domain protein MIPOCGNA_01026 322159.STER_1072 2.6e-129 468.0 Bacilli deoD GO:0003674,GO:0003824,GO:0004731,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006152,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009116,GO:0009164,GO:0009987,GO:0015949,GO:0016740,GO:0016757,GO:0016763,GO:0019439,GO:0019686,GO:0033554,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042802,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658 2.4.2.1,2.4.2.28 ko:K00772,ko:K03784 ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110 M00034 R01402,R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122,RC02819 ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_1997,iB21_1397.B21_04226,iE2348C_1286.E2348C_4682,iEC042_1314.EC042_4881,iECABU_c1320.ECABU_c50190,iECBD_1354.ECBD_3636,iECB_1328.ECB_04260,iECD_1391.ECD_04260,iECED1_1282.ECED1_5255,iECIAI39_1322.ECIAI39_4916,iECNA114_1301.ECNA114_4626,iECO26_1355.ECO26_5590,iECOK1_1307.ECOK1_4950,iECP_1309.ECP_4768,iEcolC_1368.EcolC_3672,iLF82_1304.LF82_0467,iNRG857_1313.NRG857_22170,iPC815.YPO0440,iSFV_1184.SFV_4418,iSF_1195.SF4416,iSFxv_1172.SFxv_4809,iS_1188.S4687,iUMN146_1321.UM146_22680,iUMNK88_1353.UMNK88_5303,iUTI89_1310.UTI89_C5155,ic_1306.c5468 Bacteria 1TQPG@1239,4HADM@91061,COG0813@1,COG0813@2 NA|NA|NA F purine nucleoside phosphorylase MIPOCGNA_01027 904306.HMPREF9192_1673 1.5e-124 452.2 Bacilli yfeJ 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 Bacteria 1V97T@1239,4HIKV@91061,COG0518@1,COG0518@2 NA|NA|NA F glutamine amidotransferase MIPOCGNA_01028 904306.HMPREF9192_1672 3.5e-56 224.2 Firmicutes clcA_2 ko:K03281 ko00000 2.A.49 Bacteria 1V07H@1239,COG0038@1,COG0038@2 NA|NA|NA P chloride MIPOCGNA_01029 904306.HMPREF9192_1672 1.1e-58 232.6 Firmicutes clcA_2 ko:K03281 ko00000 2.A.49 Bacteria 1V07H@1239,COG0038@1,COG0038@2 NA|NA|NA P chloride MIPOCGNA_01030 264199.stu1117 1.3e-148 532.3 Bacilli punA 2.4.2.1 ko:K03783 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122 ko00000,ko00001,ko01000 Bacteria 1TQ37@1239,4HABP@91061,COG0005@1,COG0005@2 NA|NA|NA F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate MIPOCGNA_01031 904306.HMPREF9192_1670 1.3e-88 332.4 Bacteria Bacteria COG3797@1,COG3797@2 NA|NA|NA S Protein of unknown function (DUF1697) MIPOCGNA_01032 264199.stu1120 1.2e-235 822.0 Bacilli deoB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008973,GO:0016853,GO:0016866,GO:0016868,GO:0044424,GO:0044444,GO:0044464 5.4.2.7 ko:K01839 ko00030,ko00230,map00030,map00230 R01057,R02749 RC00408 ko00000,ko00001,ko01000 Bacteria 1TP70@1239,4H9RU@91061,COG1015@1,COG1015@2 NA|NA|NA G Phosphotransfer between the C1 and C5 carbon atoms of pentose MIPOCGNA_01033 264199.stu1121 1.9e-121 441.8 Bacilli rpiA GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 2.7.1.12,2.7.1.15,5.3.1.6 ko:K00851,ko:K00852,ko:K01807 ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167,M00580 R01051,R01056,R01737,R02750 RC00002,RC00017,RC00434 ko00000,ko00001,ko00002,ko01000 Bacteria 1V1DB@1239,4HFQ7@91061,COG0120@1,COG0120@2 NA|NA|NA G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate MIPOCGNA_01035 1316408.HSISM1_134 5.7e-08 62.8 Bacilli Bacteria 1VU2V@1239,4HU5W@91061,COG3266@1,COG3266@2 NA|NA|NA V Glucan-binding protein C MIPOCGNA_01036 435842.HMPREF0848_00593 3.6e-22 110.9 Bacilli Bacteria 1VU2V@1239,4HU5W@91061,COG3266@1,COG3266@2 NA|NA|NA V Glucan-binding protein C MIPOCGNA_01037 322159.STER_1082 2.4e-112 411.4 Bacilli ung2 3.2.2.27 ko:K21929 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 1V1F8@1239,4HFVS@91061,COG1573@1,COG1573@2 NA|NA|NA L Uracil-DNA glycosylase MIPOCGNA_01038 264199.stu1127 9e-275 952.2 Bacilli pepV 3.5.1.18 ko:K01270,ko:K01274,ko:K01439 ko00300,ko00480,ko01100,ko01120,ko01230,map00300,map00480,map01100,map01120,map01230 M00016 R00899,R02734,R04951 RC00064,RC00090,RC00096,RC00141 ko00000,ko00001,ko00002,ko01000,ko01002 Bacteria 1TPEG@1239,4HC14@91061,COG0624@1,COG0624@2 NA|NA|NA E Dipeptidase MIPOCGNA_01039 264199.stu1128 5.4e-26 122.9 Bacilli dmpI GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0044237 5.3.2.6 ko:K01821 ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220 M00569 R03966,R05389 RC01040,RC01355 ko00000,ko00001,ko00002,ko01000 Bacteria 1VKD5@1239,4HRBS@91061,COG1942@1,COG1942@2 NA|NA|NA G Belongs to the 4-oxalocrotonate tautomerase family MIPOCGNA_01040 264199.stu1129 2e-41 174.9 Bacilli XK27_03610 Bacteria 1V77V@1239,4HKYX@91061,COG0454@1,COG0456@2 NA|NA|NA K Gnat family MIPOCGNA_01041 264199.stu1807 4.6e-82 310.5 Bacilli ko:K07491 ko00000 Bacteria 1V1CM@1239,4HGN6@91061,COG1943@1,COG1943@2 NA|NA|NA L Transposase MIPOCGNA_01042 1123299.AUKZ01000036_gene1534 1e-13 81.6 Bacteria rpmH GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02914 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria COG0230@1,COG0230@2 NA|NA|NA J Ribosomal protein L34 MIPOCGNA_01043 1069533.Sinf_1766 1.5e-258 898.3 Bacilli Bacteria 1UIMF@1239,2AQ9M@1,31FFI@2,4ISND@91061 NA|NA|NA S Uncharacterised protein family (UPF0236) MIPOCGNA_01046 765869.BDW_06300 7.9e-12 78.2 Deltaproteobacteria Bacteria 1PG5I@1224,2DB9D@1,2WU4Y@28221,2Z7WA@2,42YZF@68525 NA|NA|NA S TIR domain MIPOCGNA_01047 1069533.Sinf_1780 1.7e-69 268.5 Firmicutes Bacteria 1TZWX@1239,COG3177@1,COG3177@2 NA|NA|NA M Filamentation induced by cAMP protein fic MIPOCGNA_01049 1069533.Sinf_1782 9.2e-89 332.8 Bacilli ko:K03496 ko00000,ko03036,ko04812 Bacteria 1V6Q6@1239,4HINH@91061,COG1192@1,COG1192@2 NA|NA|NA D CobQ CobB MinD ParA nucleotide binding domain protein MIPOCGNA_01050 768486.EHR_06450 8.6e-232 809.7 Enterococcaceae Bacteria 1VXZJ@1239,4B6ME@81852,4HXMC@91061,COG5617@1,COG5617@2 NA|NA|NA S Psort location CytoplasmicMembrane, score MIPOCGNA_01052 1116231.SMA_1998 2.2e-81 308.5 Bacilli tnpR Bacteria 1UZM8@1239,4IQ67@91061,COG1961@1,COG1961@2 NA|NA|NA L Resolvase, N terminal domain MIPOCGNA_01054 1069533.Sinf_1786 2.9e-277 960.7 Bacilli Bacteria 1V2SB@1239,4HFEX@91061,COG3843@1,COG3843@2 NA|NA|NA U relaxase MIPOCGNA_01055 862969.SCI_0826 3.7e-26 124.4 Streptococcus anginosus group Bacteria 1TVZI@1239,2BCE6@1,325ZM@2,42EGC@671232,4I4MU@91061 NA|NA|NA S Bacterial mobilisation protein (MobC) MIPOCGNA_01057 1116231.SMA_2004 0.0 2514.6 Bacilli 2.1.1.72,3.1.21.3 ko:K00571,ko:K01154 ko00000,ko01000,ko02048 Bacteria 1TQN4@1239,4HN8F@91061,COG0358@1,COG0358@2,COG0827@1,COG0827@2,COG4227@1,COG4227@2 NA|NA|NA L Psort location Cytoplasmic, score MIPOCGNA_01059 1069533.Sinf_1791 0.0 1128.2 Bacilli topB 5.99.1.2 ko:K03169 ko00000,ko01000,ko03032 Bacteria 1TPJD@1239,4HAZV@91061,COG0550@1,COG0550@2 NA|NA|NA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone MIPOCGNA_01062 1116231.SMA_2009 0.0 1367.4 Bacilli ko:K03205 ko03070,map03070 M00333 ko00000,ko00001,ko00002,ko02044 3.A.7 Bacteria 1TPCF@1239,4HF20@91061,COG3505@1,COG3505@2 NA|NA|NA U An automated process has identified a potential problem with this gene model MIPOCGNA_01063 1000570.HMPREF9966_1919 8e-45 186.8 Streptococcus anginosus group Bacteria 1TVY6@1239,2DITE@1,3043F@2,42EED@671232,4I4JX@91061 NA|NA|NA S Protein of unknown function (DUF3801) MIPOCGNA_01064 1000570.HMPREF9966_1918 8.2e-55 220.7 Streptococcus anginosus group Bacteria 1TVY7@1239,2DITF@1,3043G@2,42EEF@671232,4I4K0@91061 NA|NA|NA MIPOCGNA_01066 1116231.SMA_2013 3e-63 247.7 Bacteria ssb ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 ko00000,ko00001,ko03029,ko03032,ko03400 Bacteria COG0629@1,COG0629@2 NA|NA|NA L single-stranded DNA binding MIPOCGNA_01067 1069533.Sinf_1798 9.1e-99 366.3 Bacilli Bacteria 1VDM9@1239,2DNFF@1,32X8K@2,4HNCS@91061 NA|NA|NA MIPOCGNA_01068 1116231.SMA_2015 0.0 1444.1 Bacilli ko:K21471 ko00000,ko01000,ko01002,ko01011 Bacteria 1VPFZ@1239,4HFGV@91061,COG3942@1,COG3942@2 NA|NA|NA M CHAP domain protein MIPOCGNA_01069 1116231.SMA_2017 0.0 1529.6 Bacilli Bacteria 1TPDR@1239,4HC47@91061,COG3451@1,COG3451@2 NA|NA|NA U Psort location Cytoplasmic, score MIPOCGNA_01070 1000570.HMPREF9966_1913 1.6e-42 178.7 Streptococcus anginosus group Bacteria 1TVYC@1239,2DITG@1,3043I@2,42EER@671232,4I4K8@91061 NA|NA|NA S PrgI family protein MIPOCGNA_01071 1000570.HMPREF9966_1910 1.5e-90 339.3 Streptococcus anginosus group Bacteria 1TVTV@1239,2DISC@1,3041F@2,42E19@671232,4I48P@91061 NA|NA|NA MIPOCGNA_01072 1000570.HMPREF9966_1909 4.1e-24 118.2 Streptococcus anginosus group Bacteria 1TW0I@1239,2BPSY@1,32IKA@2,42EHF@671232,4I4P8@91061 NA|NA|NA MIPOCGNA_01073 1000570.HMPREF9966_1908 8.9e-15 85.9 Streptococcus anginosus group Bacteria 1UGAQ@1239,29V7U@1,30GMQ@2,42EGF@671232,4I4MW@91061 NA|NA|NA MIPOCGNA_01074 1069533.Sinf_1806 0.0 1618.6 Bacteria Bacteria COG3087@1,COG3087@2 NA|NA|NA D Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides MIPOCGNA_01075 862969.SCI_0808 8.6e-20 104.4 Streptococcus anginosus group ko:K06236 ko04151,ko04510,ko04512,ko04611,ko04926,ko04933,ko04974,ko05146,ko05165,map04151,map04510,map04512,map04611,map04926,map04933,map04974,map05146,map05165 ko00000,ko00001,ko00536,ko04516 Bacteria 1UMUJ@1239,42EFA@671232,4IU0F@91061,COG3468@1,COG3468@2 NA|NA|NA MU outer membrane autotransporter barrel domain protein MIPOCGNA_01076 862971.SANR_1416 7e-13 80.1 Streptococcus anginosus group Bacteria 1TW11@1239,2DIUA@1,3044T@2,42EI4@671232,4I4PX@91061 NA|NA|NA MIPOCGNA_01078 1000570.HMPREF9966_1901 6.2e-87 327.8 Bacilli repA Bacteria 1VHQA@1239,2DP1C@1,3304N@2,4HPY6@91061 NA|NA|NA S Replication initiator protein A MIPOCGNA_01081 264199.stu1809 3.2e-184 651.0 Bacilli jag ko:K06346 ko00000 Bacteria 1V3IN@1239,4HHHU@91061,COG1847@1,COG1847@2 NA|NA|NA S RNA-binding protein MIPOCGNA_01082 264199.stu1810 8.5e-141 506.5 Bacilli yidC ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 Bacteria 1TQ0J@1239,4HB3J@91061,COG0706@1,COG0706@2 NA|NA|NA U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins MIPOCGNA_01083 264199.stu1811 1.3e-54 218.8 Bacilli rnpA GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031123,GO:0031404,GO:0031974,GO:0031981,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043628,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904 3.1.26.5 ko:K03536,ko:K08998 ko00000,ko01000,ko03016 Bacteria 1VA78@1239,4HKG6@91061,COG0594@1,COG0594@2 NA|NA|NA J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme MIPOCGNA_01084 264199.stu1812 1.2e-263 915.2 Bacilli argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1TNZ6@1239,4HB24@91061,COG0165@1,COG0165@2 NA|NA|NA E Argininosuccinate lyase MIPOCGNA_01085 264199.stu1813 3.4e-230 803.9 Bacilli argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 iJN678.argG,iSB619.SA_RS04675 Bacteria 1TP3X@1239,4HA1E@91061,COG0137@1,COG0137@2 NA|NA|NA E Belongs to the argininosuccinate synthase family. Type 1 subfamily MIPOCGNA_01086 264199.stu1814 1.5e-280 971.5 Bacilli gltX GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009986,GO:0030246,GO:0030247,GO:0044424,GO:0044464,GO:2001065 6.1.1.17,6.1.1.24 ko:K01885,ko:K09698 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R03651,R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 iSB619.SA_RS02860 Bacteria 1TPJC@1239,4HAKH@91061,COG0008@1,COG0008@2 NA|NA|NA J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) MIPOCGNA_01087 264199.stu1815 6.7e-81 306.6 Bacteria amiA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02035,ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria COG4166@1,COG4166@2 NA|NA|NA E transmembrane transport MIPOCGNA_01088 264199.stu1816 7.3e-69 266.5 Bacteria amiA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02035,ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria COG4166@1,COG4166@2 NA|NA|NA E transmembrane transport MIPOCGNA_01089 264199.stu1817 4.8e-120 437.2 Bacilli rplA GO:0000027,GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006417,GO:0006446,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0017148,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045947,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02863 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1TPTS@1239,4HAK4@91061,COG0081@1,COG0081@2 NA|NA|NA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release MIPOCGNA_01090 264199.stu1818 3.7e-70 270.8 Bacilli rplK GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010467,GO:0015934,GO:0015968,GO:0016043,GO:0019538,GO:0019843,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0032984,GO:0032991,GO:0033554,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0042594,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0051716,GO:0065003,GO:0070925,GO:0071496,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02867 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V1BS@1239,4HFQ0@91061,COG0080@1,COG0080@2 NA|NA|NA J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors MIPOCGNA_01091 264199.stu1819 9.2e-51 206.1 Firmicutes Bacteria 1VNK9@1239,2DSU9@1,33HF9@2 NA|NA|NA S Protein of unknown function (DUF3397) MIPOCGNA_01092 264199.stu1820 2e-88 331.6 Bacilli cah 4.2.1.1 ko:K01673 ko00910,map00910 R00132,R10092 RC02807 ko00000,ko00001,ko01000 Bacteria 1V0TA@1239,4HB9V@91061,COG0288@1,COG0288@2 NA|NA|NA P Reversible hydration of carbon dioxide MIPOCGNA_01093 904306.HMPREF9192_2050 9.3e-34 149.1 Bacilli WQ51_05710 Bacteria 1V6BD@1239,4HIAR@91061,COG2013@1,COG2013@2 NA|NA|NA S Mitochondrial biogenesis AIM24 MIPOCGNA_01094 264199.stu1822 6.8e-32 142.9 Bacteria WQ51_05710 Bacteria COG2013@1,COG2013@2 NA|NA|NA S Mitochondrial biogenesis AIM24 MIPOCGNA_01095 435842.HMPREF0848_01845 1.4e-11 74.3 Bacilli WQ51_05710 Bacteria 1V6BD@1239,4HIAR@91061,COG2013@1,COG2013@2 NA|NA|NA S Mitochondrial biogenesis AIM24 MIPOCGNA_01096 264199.stu1823 9.9e-225 785.8 Bacilli radA ko:K04485 ko00000,ko03400 Bacteria 1TQ7Y@1239,4H9YC@91061,COG1066@1,COG1066@2 NA|NA|NA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function MIPOCGNA_01097 1095738.HMPREF1047_1312 2.4e-75 288.1 Bacteria 3.5.1.19 ko:K08281 ko00760,ko01100,map00760,map01100 R01268 RC00100 ko00000,ko00001,ko01000 Bacteria COG1335@1,COG1335@2 NA|NA|NA Q hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides MIPOCGNA_01098 264199.stu1824 7e-80 303.1 Bacilli dut GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23,4.1.1.36,6.3.2.5 ko:K01520,ko:K13038 ko00240,ko00770,ko00983,ko01100,map00240,map00770,map00983,map01100 M00053,M00120 R02100,R03269,R04231,R11896 RC00002,RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000,ko03400 Bacteria 1V6HX@1239,4HIZ3@91061,COG0756@1,COG0756@2 NA|NA|NA F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA MIPOCGNA_01099 264199.stu1825 1.8e-19 100.9 Bacteria XK27_09620 Bacteria COG0431@1,COG0431@2 NA|NA|NA S FMN reductase (NADPH) activity MIPOCGNA_01100 1046629.Ssal_00181 7.8e-35 152.5 Bacteria XK27_09620 Bacteria COG0431@1,COG0431@2 NA|NA|NA S FMN reductase (NADPH) activity MIPOCGNA_01101 904306.HMPREF9192_2046 4.2e-223 780.4 Bacilli XK27_09615 Bacteria 1TPRA@1239,4HDA5@91061,COG0431@1,COG0431@2,COG2461@1,COG2461@2 NA|NA|NA C reductase MIPOCGNA_01103 435842.HMPREF0848_01839 2.1e-71 275.0 Bacilli fnt ko:K06212,ko:K21993 ko00000,ko02000 1.A.16.1.1,1.A.16.1.3,1.A.16.2 Bacteria 1V164@1239,4HFJC@91061,COG2116@1,COG2116@2 NA|NA|NA P Formate nitrite transporter MIPOCGNA_01104 1046629.Ssal_00177 9e-76 289.7 Bacteria XK27_08585 ko:K16926 M00582 ko00000,ko00002,ko02000 3.A.1.31 Bacteria 2BY0N@1,321KG@2 NA|NA|NA S Psort location CytoplasmicMembrane, score MIPOCGNA_01105 264199.stu1832 7e-184 649.8 Bacilli gpsA GO:0003674,GO:0003824,GO:0004367,GO:0006072,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0046167,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901576 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 R00842,R00844 RC00029 ko00000,ko00001,ko01000 Bacteria 1TQ5P@1239,4HAXW@91061,COG0240@1,COG0240@2 NA|NA|NA I Glycerol-3-phosphate dehydrogenase MIPOCGNA_01106 264199.stu1833 1.7e-165 588.6 Bacilli galU 2.7.7.9 ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 M00129,M00361,M00362,M00549 R00289 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQ24@1239,4HATY@91061,COG1210@1,COG1210@2 NA|NA|NA M UTP-glucose-1-phosphate uridylyltransferase MIPOCGNA_01107 264199.stu1836 3.1e-116 424.5 Bacilli gluP 3.4.21.105 ko:K19225 ko00000,ko01000,ko01002 Bacteria 1TQXT@1239,4HCDF@91061,COG0705@1,COG0705@2 NA|NA|NA O membrane protein (homolog of Drosophila rhomboid) MIPOCGNA_01108 264199.stu1837 4.5e-94 350.5 Bacilli ygfA GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0022611,GO:0030272,GO:0032502,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 R02301 RC00183 ko00000,ko00001,ko01000 iECABU_c1320.ECABU_c31940,iECOK1_1307.ECOK1_3298,iECSF_1327.ECSF_2705,iUTI89_1310.UTI89_C3298 Bacteria 1VA91@1239,4HM35@91061,COG0212@1,COG0212@2 NA|NA|NA H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family MIPOCGNA_01109 264199.stu1838 8.7e-220 769.2 Bacilli hipO GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0050118,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.1.47 ko:K01436,ko:K05823,ko:K21613 ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230 M00525 R02733 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000,ko01002 Bacteria 1TPD7@1239,4H9SG@91061,COG1473@1,COG1473@2 NA|NA|NA E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate MIPOCGNA_01110 264199.stu1839 8.1e-59 233.8 Bacilli dapD GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008666,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016749,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.117,2.3.1.89 ko:K00674,ko:K05822 ko00300,ko01100,ko01110,ko01120,ko01230,map00300,map01100,map01110,map01120,map01230 M00016,M00525 R04364,R04365 RC00004,RC01136 ko00000,ko00001,ko00002,ko01000 iSbBS512_1146.SbBS512_E0158,iYO844.BSU14180 Bacteria 1TQUJ@1239,4H9KY@91061,COG2171@1,COG2171@2 NA|NA|NA E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate MIPOCGNA_01111 1046629.Ssal_00169 1.5e-117 429.1 Bacilli ko:K07025 ko00000 Bacteria 1V73N@1239,4IU82@91061,COG0546@1,COG0546@2 NA|NA|NA S HAD hydrolase, family IA, variant MIPOCGNA_01112 322159.STER_1816 6.3e-159 566.6 Bacteria rrmA 2.1.1.187 ko:K00563,ko:K10947 R07233 RC00003 ko00000,ko01000,ko03000,ko03009 Bacteria COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase MIPOCGNA_01115 322159.STER_1819 1.2e-91 342.4 Bacilli tadA 3.5.4.1,3.5.4.33 ko:K01485,ko:K11991 ko00240,ko00330,ko01100,map00240,map00330,map01100 R00974,R01411,R02922,R10223 RC00074,RC00477,RC00514,RC00809 ko00000,ko00001,ko01000,ko03016 Bacteria 1V3HZ@1239,4HH7S@91061,COG0590@1,COG0590@2 NA|NA|NA FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) MIPOCGNA_01116 322159.STER_1821 5.1e-66 256.9 Bacilli ssb_2 ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 ko00000,ko00001,ko03029,ko03032,ko03400 Bacteria 1VXMZ@1239,4HXCW@91061,COG0629@1,COG0629@2 NA|NA|NA L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism MIPOCGNA_01117 322159.STER_1822 4.1e-36 156.8 Bacteria yeeD GO:0008150,GO:0009987,GO:0019725,GO:0042592,GO:0048878,GO:0055082,GO:0065007,GO:0065008 ko:K07112 ko00000 Bacteria COG0425@1,COG0425@2 NA|NA|NA O sulfur carrier activity MIPOCGNA_01118 264199.stu1847 3.6e-188 664.1 Bacilli yeeE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K07112 ko00000 Bacteria 1TSNG@1239,4HDN0@91061,COG2391@1,COG2391@2 NA|NA|NA S Sulphur transport MIPOCGNA_01119 264199.stu1848 3.9e-113 414.1 Bacilli pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890,ko:K06878 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1V7QA@1239,4HJBD@91061,COG0073@1,COG0073@2 NA|NA|NA J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily MIPOCGNA_01120 264199.stu1849 2.1e-54 218.0 Bacilli ytpP GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 2.7.1.180,5.3.4.1 ko:K01829,ko:K03671,ko:K03734,ko:K06196 ko04621,ko05418,map04621,map05418 ko00000,ko00001,ko01000,ko02000,ko03110 5.A.1.2 Bacteria 1VAS6@1239,4HKGM@91061,COG0526@1,COG0526@2 NA|NA|NA CO Thioredoxin MIPOCGNA_01121 1035184.HMPREF1042_1989 1.4e-09 68.9 Streptococcus anginosus group Bacteria 1TVXJ@1239,2BV7J@1,32QM1@2,42EDG@671232,4I4JA@91061 NA|NA|NA S Domain of unknown function (DUF4651) MIPOCGNA_01122 322159.STER_1827 2e-205 721.5 Bacilli pepA 3.4.11.7 ko:K01261,ko:K01269 ko00000,ko01000,ko01002 Bacteria 1TNZT@1239,4H9SM@91061,COG1363@1,COG1363@2 NA|NA|NA G COG1363 Cellulase M and related proteins MIPOCGNA_01123 264199.stu1852 3.9e-131 474.2 Bacilli proC 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP1E@1239,4HCBY@91061,COG0345@1,COG0345@2 NA|NA|NA E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline MIPOCGNA_01124 264199.stu1853 9.6e-110 402.9 Bacilli ko:K07052 ko00000 Bacteria 1VEE2@1239,4HP4A@91061,COG1266@1,COG1266@2 NA|NA|NA S CAAX amino terminal protease family protein MIPOCGNA_01126 264199.stu1855 1.3e-33 149.1 Bacteria ko:K07052 ko00000 Bacteria COG1266@1,COG1266@2 NA|NA|NA V CAAX protease self-immunity MIPOCGNA_01127 1046629.Ssal_00152 1.8e-33 148.3 Bacteria ko:K07052 ko00000 Bacteria COG1266@1,COG1266@2 NA|NA|NA V CAAX protease self-immunity MIPOCGNA_01128 1046629.Ssal_00151 2.6e-26 124.0 Bacteria lanR ko:K07729 ko00000,ko03000 Bacteria COG1476@1,COG1476@2 NA|NA|NA K sequence-specific DNA binding MIPOCGNA_01129 264199.stu1857 3.2e-220 770.8 Bacilli ackA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv0409 Bacteria 1TQ22@1239,4HA7K@91061,COG0282@1,COG0282@2 NA|NA|NA F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction MIPOCGNA_01130 264199.stu1858 4.2e-175 620.5 Bacilli ytxK 2.1.1.72 ko:K00571 ko00000,ko01000,ko02048 Bacteria 1TRIQ@1239,4H9SE@91061,COG0827@1,COG0827@2 NA|NA|NA L DNA methylase MIPOCGNA_01131 1198676.SMUGS5_08910 2.2e-11 75.1 Bacilli comGF ko:K02246,ko:K02248 M00429 ko00000,ko00002,ko02044 Bacteria 1VJKM@1239,4HQDT@91061,COG4940@1,COG4940@2 NA|NA|NA U Putative Competence protein ComGF MIPOCGNA_01132 322159.STER_1837 1.3e-70 272.3 Bacilli comGF ko:K02246,ko:K02248 M00429 ko00000,ko00002,ko02044 Bacteria 1VKRP@1239,4HR6S@91061,COG4940@1,COG4940@2 NA|NA|NA U Competence protein ComGF MIPOCGNA_01133 873449.STRCR_0577 4.1e-15 87.0 Firmicutes Bacteria 1W385@1239,2ZS6J@2,COG2165@1 NA|NA|NA NU Type II secretory pathway pseudopilin MIPOCGNA_01134 264199.stu1862 2.6e-56 224.6 Bacilli cglD ko:K02246 M00429 ko00000,ko00002,ko02044 Bacteria 1VPGT@1239,33A38@2,4HRZ0@91061,COG2165@1 NA|NA|NA NU Competence protein MIPOCGNA_01135 322159.STER_1840 2.5e-42 177.9 Bacilli comGC GO:0005575,GO:0005623,GO:0005886,GO:0009986,GO:0016020,GO:0044464,GO:0071944 ko:K02245,ko:K02456 ko03070,ko05111,map03070,map05111 M00331,M00429 ko00000,ko00001,ko00002,ko02044 3.A.15 Bacteria 1VFI9@1239,4HNNT@91061,COG4537@1,COG4537@2 NA|NA|NA U Required for transformation and DNA binding MIPOCGNA_01136 264199.stu1864 1e-151 542.7 Bacilli cglB ko:K02244 M00429 ko00000,ko00002,ko02044 3.A.14.1 Bacteria 1U00C@1239,4HGUA@91061,COG1459@1,COG1459@2 NA|NA|NA NU type II secretion system MIPOCGNA_01137 322159.STER_1842 6.4e-176 623.2 Bacilli comGA ko:K02243 M00429 ko00000,ko00002,ko02044 3.A.14.1 Bacteria 1TPGE@1239,4HB0C@91061,COG2804@1,COG2804@2 NA|NA|NA NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB MIPOCGNA_01138 264199.stu1866 3.2e-67 260.8 Bacilli Bacteria 1VHC7@1239,4HS15@91061,COG4699@1,COG4699@2 NA|NA|NA S cog cog4699 MIPOCGNA_01139 322159.STER_1844 0.0 2382.4 Bacilli rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 1TNYT@1239,4HA24@91061,COG0086@1,COG0086@2 NA|NA|NA K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates MIPOCGNA_01140 322159.STER_1845 0.0 2295.8 Bacilli rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 1TP96@1239,4H9PK@91061,COG0085@1,COG0085@2 NA|NA|NA K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates MIPOCGNA_01141 264199.stu1869 0.0 1562.7 Bacilli pbp1B 2.4.1.129,3.4.16.4 ko:K03693,ko:K05365,ko:K05366,ko:K05367,ko:K12551,ko:K12555,ko:K21464 ko00550,ko01100,ko01501,map00550,map01100,map01501 R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 GT51 Bacteria 1TPM5@1239,4H9SA@91061,COG0744@1,COG0744@2 NA|NA|NA M penicillin-binding protein MIPOCGNA_01142 264199.stu1870 2.1e-238 831.2 Bacilli tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006437,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 iAF1260.b1637,iBWG_1329.BWG_1452,iECDH10B_1368.ECDH10B_1771,iECDH1ME8569_1439.ECDH1ME8569_1581,iECH74115_1262.ECH74115_2349,iECIAI39_1322.ECIAI39_1418,iECNA114_1301.ECNA114_1685,iECO103_1326.ECO103_1778,iECO111_1330.ECO111_2107,iECO26_1355.ECO26_2366,iECSE_1348.ECSE_1760,iECSF_1327.ECSF_1500,iECSP_1301.ECSP_2202,iECUMN_1333.ECUMN_1928,iECW_1372.ECW_m1805,iECs_1301.ECs2346,iEKO11_1354.EKO11_2137,iETEC_1333.ETEC_1672,iEcDH1_1363.EcDH1_2003,iEcE24377_1341.EcE24377A_1847,iEcHS_1320.EcHS_A1713,iEcSMS35_1347.EcSMS35_1562,iEcolC_1368.EcolC_1992,iJO1366.b1637,iSFV_1184.SFV_1654,iSF_1195.SF1662,iSSON_1240.SSON_1519,iSbBS512_1146.SbBS512_E1829,iUMNK88_1353.UMNK88_2097,iWFL_1372.ECW_m1805,iY75_1357.Y75_RS08585 Bacteria 1TPGN@1239,4H9YV@91061,COG0162@1,COG0162@2 NA|NA|NA J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) MIPOCGNA_01143 322159.STER_1848 1.6e-196 691.8 Bacilli ilvC 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPI7@1239,4HADK@91061,COG0059@1,COG0059@2 NA|NA|NA H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate MIPOCGNA_01144 264199.stu1872 1.1e-75 289.3 Bacilli ilvN GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 ko:K01653,ko:K16785 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230,map02010 M00019,M00570,M00582 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 Bacteria 1V2AJ@1239,4HDY5@91061,COG0440@1,COG0440@2 NA|NA|NA E Acetolactate synthase MIPOCGNA_01145 264199.stu1873 0.0 1104.4 Bacilli ilvB 2.2.1.6 ko:K01652,ko:K16787 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230,map02010 M00019,M00570,M00582 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 iYO844.BSU28310 Bacteria 1TQE8@1239,4H9VR@91061,COG0028@1,COG0028@2 NA|NA|NA EH Acetolactate synthase MIPOCGNA_01146 322159.STER_1851 0.0 1117.1 Bacilli ilvD 4.2.1.9 ko:K01687,ko:K16786 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00770,map01100,map01110,map01130,map01210,map01230,map02010 M00019,M00570,M00582 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 iAF987.Gmet_1259 Bacteria 1TP1R@1239,4H9ZG@91061,COG0129@1,COG0129@2 NA|NA|NA E Belongs to the IlvD Edd family MIPOCGNA_01147 264199.stu1875 6.7e-301 1039.3 Bacilli yloV ko:K07030 ko00000 Bacteria 1TQMX@1239,4HBSE@91061,COG1461@1,COG1461@2 NA|NA|NA S kinase related to dihydroxyacetone kinase MIPOCGNA_01148 322159.STER_1855 1.8e-57 228.4 Bacilli asp Bacteria 1V3Q6@1239,4HHYJ@91061,COG1302@1,COG1302@2 NA|NA|NA S cog cog1302 MIPOCGNA_01149 322159.STER_1856 2.7e-225 787.7 Bacilli norN ko:K03327 ko00000,ko02000 2.A.66.1 Bacteria 1TQMT@1239,4H9Y2@91061,COG0534@1,COG0534@2 NA|NA|NA V Mate efflux family protein MIPOCGNA_01150 322159.STER_1857 1.9e-278 964.5 Bacilli thrC 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS16355,iIT341.HP0098 Bacteria 1TPR0@1239,4H9R7@91061,COG0498@1,COG0498@2 NA|NA|NA E Threonine synthase MIPOCGNA_01151 904306.HMPREF9192_1994 7.5e-39 166.0 Bacilli adhE 1.1.1.1,1.2.1.10 ko:K04072 ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220 R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927 RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195 ko00000,ko00001,ko01000 iSB619.SA_RS00885 Bacteria 1TPB4@1239,4HAN8@91061,COG1012@1,COG1012@2,COG1454@1,COG1454@2 NA|NA|NA C belongs to the iron- containing alcohol dehydrogenase family MIPOCGNA_01152 264199.stu1880 5.6e-29 132.9 Bacteria adhE 1.1.1.1,1.2.1.10 ko:K04072 ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220 R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927 RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195 ko00000,ko00001,ko01000 iSB619.SA_RS00885 Bacteria COG1454@1,COG1454@2 NA|NA|NA C hydroxyacid-oxoacid transhydrogenase activity MIPOCGNA_01153 264199.stu1881 7e-66 256.5 Bacilli adhE 1.1.1.1,1.2.1.10 ko:K04072 ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220 R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927 RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195 ko00000,ko00001,ko01000 iSB619.SA_RS00885 Bacteria 1TPB4@1239,4HAN8@91061,COG1454@1,COG1454@2 NA|NA|NA C belongs to the iron- containing alcohol dehydrogenase family MIPOCGNA_01154 904306.HMPREF9192_1994 2.1e-135 488.4 Bacilli adhE 1.1.1.1,1.2.1.10 ko:K04072 ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220 R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927 RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195 ko00000,ko00001,ko01000 iSB619.SA_RS00885 Bacteria 1TPB4@1239,4HAN8@91061,COG1012@1,COG1012@2,COG1454@1,COG1454@2 NA|NA|NA C belongs to the iron- containing alcohol dehydrogenase family MIPOCGNA_01155 264199.stu1884 3.6e-64 250.8 Bacilli adhE 1.1.1.1,1.2.1.10 ko:K04072 ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220 R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927 RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195 ko00000,ko00001,ko01000 iSB619.SA_RS00885 Bacteria 1UHQT@1239,4IS6J@91061,COG1012@1,COG1012@2 NA|NA|NA C Dehydrogenase MIPOCGNA_01156 322159.STER_1860 0.0 1279.6 Bacilli pepO 3.4.24.71 ko:K01415,ko:K07386 ko00000,ko01000,ko01002,ko04147 Bacteria 1TQTA@1239,4HDSF@91061,COG3590@1,COG3590@2 NA|NA|NA O Peptidase family M13 MIPOCGNA_01157 264199.stu1886 3.9e-54 217.2 Bacilli treC GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005991,GO:0005993,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008788,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0015927,GO:0016052,GO:0016787,GO:0016798,GO:0033554,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046352,GO:0050896,GO:0051716,GO:0071704,GO:1901575 3.2.1.93 ko:K01226 ko00500,map00500 R00837,R06113 RC00049 ko00000,ko00001,ko01000 GH13 iECW_1372.ECW_m4600,iEKO11_1354.EKO11_4072,iEcE24377_1341.EcE24377A_4811,iEcSMS35_1347.EcSMS35_4720,iWFL_1372.ECW_m4600 Bacteria 1TP53@1239,4HA1G@91061,COG0366@1,COG0366@2 NA|NA|NA G COG0366 Glycosidases MIPOCGNA_01158 1046629.Ssal_00120 1.6e-41 175.3 Bacilli treC GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005991,GO:0005993,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008788,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0015927,GO:0016052,GO:0016787,GO:0016798,GO:0033554,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046352,GO:0050896,GO:0051716,GO:0071704,GO:1901575 3.2.1.93 ko:K01226 ko00500,map00500 R00837,R06113 RC00049 ko00000,ko00001,ko01000 GH13 iECW_1372.ECW_m4600,iEKO11_1354.EKO11_4072,iEcE24377_1341.EcE24377A_4811,iEcSMS35_1347.EcSMS35_4720,iWFL_1372.ECW_m4600 Bacteria 1TP53@1239,4HA1G@91061,COG0366@1,COG0366@2 NA|NA|NA G COG0366 Glycosidases MIPOCGNA_01159 1114965.Spaf_1558 5.5e-80 303.5 Bacilli treC GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005991,GO:0005993,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008788,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0015927,GO:0016052,GO:0016787,GO:0016798,GO:0033554,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046352,GO:0050896,GO:0051716,GO:0071704,GO:1901575 3.2.1.93 ko:K01226 ko00500,map00500 R00837,R06113 RC00049 ko00000,ko00001,ko01000 GH13 iECW_1372.ECW_m4600,iEKO11_1354.EKO11_4072,iEcE24377_1341.EcE24377A_4811,iEcSMS35_1347.EcSMS35_4720,iWFL_1372.ECW_m4600 Bacteria 1TP53@1239,4HA1G@91061,COG0366@1,COG0366@2 NA|NA|NA G COG0366 Glycosidases MIPOCGNA_01160 264199.stu1890 1.4e-54 218.8 Bacteria treB GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0015766,GO:0015771,GO:0015772,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090589 2.7.1.201 ko:K02817,ko:K02818,ko:K02819 ko00500,ko02060,map00500,map02060 M00270 R02780 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.2.13,4.A.1.2.4,4.A.1.2.8 iECABU_c1320.ECABU_c48060,ic_1306.c5339 Bacteria COG1263@1,COG1263@2 NA|NA|NA G PTS System MIPOCGNA_01161 264199.stu1892 2.2e-20 104.0 Bacteria treR ko:K03486,ko:K03710 ko00000,ko03000 Bacteria COG2188@1,COG2188@2 NA|NA|NA K DNA-binding transcription factor activity MIPOCGNA_01162 264199.stu1893 3.3e-86 324.3 Bacilli treR ko:K03486,ko:K03710 ko00000,ko03000 Bacteria 1TRF6@1239,4HDCX@91061,COG2188@1,COG2188@2 NA|NA|NA K trehalose operon MIPOCGNA_01163 322159.STER_1865 5.7e-95 353.6 Bacilli ywlG Bacteria 1V3H0@1239,4HH6F@91061,COG4475@1,COG4475@2 NA|NA|NA S Belongs to the UPF0340 family MIPOCGNA_01166 322159.STER_1876 8.2e-165 586.3 Bacilli fba 4.1.2.13,4.1.2.29 ko:K01624,ko:K03339 ko00010,ko00030,ko00051,ko00562,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00562,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568,R05378 RC00438,RC00439,RC00603,RC00604,RC00721 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQ01@1239,4H9ZU@91061,COG0191@1,COG0191@2 NA|NA|NA G aldolase MIPOCGNA_01168 264199.stu1900 2.1e-103 381.7 Bacteria 6.3.2.2 ko:K01919,ko:K06048 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 Bacteria COG3572@1,COG3572@2 NA|NA|NA H ergothioneine biosynthetic process MIPOCGNA_01169 1046629.Ssal_00112 7.3e-34 149.4 Bacilli 6.3.2.2 ko:K01919,ko:K06048 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 Bacteria 1TW3D@1239,4HTV4@91061,COG3572@1,COG3572@2 NA|NA|NA H gamma-glutamylcysteine synthetase MIPOCGNA_01170 904306.HMPREF9192_1984 3.2e-12 77.4 Bacilli 6.3.2.2 ko:K01919,ko:K06048 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 Bacteria 1TW3D@1239,4HTV4@91061,COG3572@1,COG3572@2 NA|NA|NA H gamma-glutamylcysteine synthetase MIPOCGNA_01171 1046629.Ssal_00544 2.7e-13 80.1 Bacilli Bacteria 1TRSF@1239,4HDM3@91061,COG2826@1,COG2826@2 NA|NA|NA L PFAM Integrase, catalytic core MIPOCGNA_01172 1046629.Ssal_00197 1.6e-71 275.4 Bacilli Bacteria 1TRSF@1239,4HDM3@91061,COG2826@1,COG2826@2 NA|NA|NA L PFAM Integrase, catalytic core MIPOCGNA_01173 264199.stu1907 3.3e-62 244.2 Bacilli rplQ GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02879,ko:K16193 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V6JQ@1239,4HGX2@91061,COG0203@1,COG0203@2 NA|NA|NA J ribosomal protein l17 MIPOCGNA_01174 264199.stu1908 6.2e-171 606.7 Bacilli rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 1TPR8@1239,4H9R1@91061,COG0202@1,COG0202@2 NA|NA|NA K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates MIPOCGNA_01175 1214166.ALLG01000006_gene1437 9.6e-62 242.7 Streptococcus suis rpsK GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02948 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V3IK@1239,1WTHI@1307,4HH2T@91061,COG0100@1,COG0100@2 NA|NA|NA J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome MIPOCGNA_01176 1046629.Ssal_00108 4e-57 227.3 Bacilli rpsM GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02952 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V3JH@1239,4HGX6@91061,COG0099@1,COG0099@2 NA|NA|NA J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits MIPOCGNA_01177 1123301.KB904201_gene1724 6e-15 85.5 Bacteria rpmJ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02919 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria COG0257@1,COG0257@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL36 family MIPOCGNA_01178 1123298.KB904065_gene2021 5.9e-32 142.9 Bacilli infA GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009986,GO:0016020,GO:0030246,GO:0030247,GO:0030312,GO:0040007,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071944,GO:2001065 ko:K02518 ko00000,ko03012 Bacteria 1V9ZK@1239,4HKF4@91061,COG0361@1,COG0361@2 NA|NA|NA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex MIPOCGNA_01179 264199.stu1913 9.2e-121 439.5 Bacilli adk GO:0003674,GO:0003824,GO:0004017,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 iHN637.CLJU_RS20110 Bacteria 1TP27@1239,4HA89@91061,COG0563@1,COG0563@2 NA|NA|NA F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism MIPOCGNA_01180 322159.STER_1887 5.1e-232 810.1 Bacilli secY GO:0002790,GO:0003674,GO:0005048,GO:0005215,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0034613,GO:0040007,GO:0042277,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5 Bacteria 1TPHB@1239,4HAWH@91061,COG0201@1,COG0201@2 NA|NA|NA U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently MIPOCGNA_01181 322159.STER_1888 1.3e-57 229.2 Bacilli rplO GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02876 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V3KE@1239,4HFPW@91061,COG0200@1,COG0200@2 NA|NA|NA J binds to the 23S rRNA MIPOCGNA_01182 264199.stu1916 2.5e-23 114.0 Bacilli rpmD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 ko:K02907 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1VEG4@1239,4HNHF@91061,COG1841@1,COG1841@2 NA|NA|NA J ribosomal protein l30 MIPOCGNA_01183 264199.stu1917 1.7e-79 302.0 Bacilli rpsE GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990145,GO:1990904 ko:K02988 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V1B1@1239,4HFN4@91061,COG0098@1,COG0098@2 NA|NA|NA J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body MIPOCGNA_01184 264199.stu1918 1.9e-56 224.9 Bacilli rplR GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02881 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V6DM@1239,4HIGF@91061,COG0256@1,COG0256@2 NA|NA|NA J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance MIPOCGNA_01185 264199.stu1919 2.3e-93 348.2 Bacilli rplF GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02933 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V1FC@1239,4HFQD@91061,COG0097@1,COG0097@2 NA|NA|NA J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center MIPOCGNA_01186 1123304.AQYA01000030_gene1163 1.6e-67 261.9 Bacilli rpsH GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009894,GO:0009987,GO:0010467,GO:0010468,GO:0010608,GO:0015935,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031323,GO:0031329,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043487,GO:0043488,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0061013,GO:0065003,GO:0065007,GO:0065008,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903311,GO:1990904 ko:K02994 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V3KK@1239,4HH32@91061,COG0096@1,COG0096@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit MIPOCGNA_01187 264199.stu1921 1.5e-28 131.3 Bacilli rpsN GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02954 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1VEF6@1239,4HNKX@91061,COG0199@1,COG0199@2 NA|NA|NA J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site MIPOCGNA_01188 264199.stu1922 1.2e-94 352.4 Bacilli rplE GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02931 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1TPE0@1239,4HBAX@91061,COG0094@1,COG0094@2 NA|NA|NA J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits MIPOCGNA_01189 264199.stu1923 1.1e-47 195.7 Bacilli rplX GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02895 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V9ZQ@1239,4HKH9@91061,COG0198@1,COG0198@2 NA|NA|NA J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit MIPOCGNA_01190 264199.stu1924 1.1e-59 235.7 Bacilli rplN GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02874 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V3N0@1239,4HGYR@91061,COG0093@1,COG0093@2 NA|NA|NA J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome MIPOCGNA_01191 1046629.Ssal_00093 6e-39 166.4 Bacilli rpsQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02961 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V9YC@1239,4HKDN@91061,COG0186@1,COG0186@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA MIPOCGNA_01192 264199.stu1926 2.7e-26 124.0 Bacilli rpmC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02904 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1VEME@1239,4HNUP@91061,COG0255@1,COG0255@2 NA|NA|NA J Belongs to the universal ribosomal protein uL29 family MIPOCGNA_01193 322159.STER_1900 1e-69 269.2 Bacilli rplP GO:0000027,GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02878 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V1AY@1239,4HFPN@91061,COG0197@1,COG0197@2 NA|NA|NA J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs MIPOCGNA_01194 264199.stu1928 2.6e-115 421.4 Bacilli rpsC GO:0000028,GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02982 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1TPCP@1239,4HAUR@91061,COG0092@1,COG0092@2 NA|NA|NA J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation MIPOCGNA_01195 1046629.Ssal_00089 7.3e-53 213.0 Bacilli rplV GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02890 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V6PU@1239,4HIK2@91061,COG0091@1,COG0091@2 NA|NA|NA J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome MIPOCGNA_01196 322159.STER_1903 4.9e-47 193.4 Bacilli rpsS GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02965 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V6CX@1239,4HIG0@91061,COG0185@1,COG0185@2 NA|NA|NA J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA MIPOCGNA_01197 264199.stu1931 2.6e-152 544.7 Bacilli rplB GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02886 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1TP9X@1239,4HAE8@91061,COG0090@1,COG0090@2 NA|NA|NA J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity MIPOCGNA_01198 264199.stu1932 2.4e-44 184.5 Bacilli rplW GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02892 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1VA4W@1239,4HKCV@91061,COG0089@1,COG0089@2 NA|NA|NA J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome MIPOCGNA_01199 1046629.Ssal_00085 2.2e-103 381.7 Bacilli rplD GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003700,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0005886,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008428,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030234,GO:0030312,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032069,GO:0032074,GO:0032268,GO:0032269,GO:0032991,GO:0032993,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060698,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0065003,GO:0065007,GO:0065009,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:0098772,GO:0140110,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990904,GO:2000112,GO:2000113,GO:2001141 ko:K02926,ko:K16193 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1TPGW@1239,4HB01@91061,COG0088@1,COG0088@2 NA|NA|NA J Forms part of the polypeptide exit tunnel MIPOCGNA_01200 264199.stu1934 5.3e-110 403.7 Bacilli rplC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010604,GO:0010628,GO:0015934,GO:0016020,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0031323,GO:0031325,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000232,GO:2000234 ko:K02906 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1TPFT@1239,4HAEN@91061,COG0087@1,COG0087@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit MIPOCGNA_01201 1046629.Ssal_00083 2.9e-48 197.6 Bacilli rpsJ GO:0001072,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006355,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0015935,GO:0019219,GO:0019222,GO:0019538,GO:0022626,GO:0022627,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043244,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0140110,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2001141 ko:K02946 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V6C9@1239,4HIKH@91061,COG0051@1,COG0051@2 NA|NA|NA J Involved in the binding of tRNA to the ribosomes MIPOCGNA_01202 264199.stu1936 6.6e-187 659.8 Bacilli ruvB GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 3.6.4.12 ko:K03551 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 1TR47@1239,4HBMW@91061,COG2255@1,COG2255@2 NA|NA|NA L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing MIPOCGNA_01203 264199.stu1937 0.0 1158.3 Bacilli XK27_09800 Bacteria 1U6DU@1239,4H9XT@91061,COG1835@1,COG1835@2 NA|NA|NA I Acyltransferase MIPOCGNA_01204 264199.stu1938 1.7e-35 155.6 Firmicutes XK27_09805 Bacteria 1TRNW@1239,COG4642@1,COG4642@2 NA|NA|NA S MORN repeat protein MIPOCGNA_01205 264199.stu1939 5.2e-80 303.5 Bacilli ptpA 3.1.3.48 ko:K01104,ko:K20945 ko05111,map05111 ko00000,ko00001,ko01000 Bacteria 1V6SG@1239,4HIZN@91061,COG0394@1,COG0394@2 NA|NA|NA T Belongs to the low molecular weight phosphotyrosine protein phosphatase family MIPOCGNA_01206 264199.stu0035 1.4e-292 1011.5 Bacilli purH GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 iJN678.purH Bacteria 1TPQ5@1239,4H9YY@91061,COG0138@1,COG0138@2 NA|NA|NA F Bifunctional purine biosynthesis protein PurH MIPOCGNA_01207 264199.stu0034 5.2e-101 373.6 Bacilli purN 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 Bacteria 1V3RJ@1239,4HGY5@91061,COG0299@1,COG0299@2 NA|NA|NA F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate MIPOCGNA_01208 904306.HMPREF9192_0010 3.6e-188 664.1 Bacilli purM GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.1,6.3.4.13 ko:K01933,ko:K11788 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144,R04208 RC00090,RC00166,RC01100 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1844,iECSF_1327.ECSF_2340 Bacteria 1TP9J@1239,4HABW@91061,COG0150@1,COG0150@2 NA|NA|NA F Phosphoribosylformylglycinamidine cyclo-ligase MIPOCGNA_01209 435842.HMPREF0848_01956 8.6e-273 945.7 Bacilli purF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 iSB619.SA_RS05225 Bacteria 1TPH3@1239,4HAXU@91061,COG0034@1,COG0034@2 NA|NA|NA F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine MIPOCGNA_01210 264199.stu0031 0.0 2408.6 Bacilli purL 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPAS@1239,4HB3N@91061,COG0046@1,COG0046@2,COG0047@1,COG0047@2 NA|NA|NA F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL MIPOCGNA_01211 264199.stu0030 4.4e-129 467.2 Bacilli purC GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016874,GO:0016879,GO:0016881,GO:0044424,GO:0044444,GO:0044464 4.1.1.21,4.3.2.2,6.3.2.6 ko:K01587,ko:K01756,ko:K01923 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04209,R04559,R04591 RC00064,RC00162,RC00379,RC00444,RC00445,RC00590 ko00000,ko00001,ko00002,ko01000 iAF1260.b2476,iB21_1397.B21_02330,iBWG_1329.BWG_2240,iE2348C_1286.E2348C_2713,iEC042_1314.EC042_2677,iEC55989_1330.EC55989_2759,iECABU_c1320.ECABU_c27880,iECBD_1354.ECBD_1213,iECB_1328.ECB_02368,iECDH10B_1368.ECDH10B_2642,iECDH1ME8569_1439.ECDH1ME8569_2402,iECDH1ME8569_1439.EcDH1_1193,iECD_1391.ECD_02368,iECED1_1282.ECED1_2911,iECH74115_1262.ECH74115_3698,iECIAI1_1343.ECIAI1_2527,iECNA114_1301.ECNA114_2561,iECO103_1326.ECO103_2988,iECO111_1330.ECO111_3199,iECO26_1355.ECO26_3522,iECOK1_1307.ECOK1_2784,iECP_1309.ECP_2490,iECS88_1305.ECS88_2658,iECSE_1348.ECSE_2760,iECSF_1327.ECSF_2329,iECSP_1301.ECSP_3415,iECUMN_1333.ECUMN_2789,iECW_1372.ECW_m2698,iECs_1301.ECs3338,iEKO11_1354.EKO11_1259,iETEC_1333.ETEC_2581,iEcDH1_1363.EcDH1_1193,iEcE24377_1341.EcE24377A_2757,iEcHS_1320.EcHS_A2607,iEcSMS35_1347.EcSMS35_2623,iEcolC_1368.EcolC_1200,iG2583_1286.G2583_2999,iJN746.PP_1240,iJO1366.b2476,iJR904.b2476,iLF82_1304.LF82_1775,iNRG857_1313.NRG857_12360,iSFV_1184.SFV_2521,iSF_1195.SF2519,iSFxv_1172.SFxv_2773,iS_1188.S2669,iSbBS512_1146.SbBS512_E2848,iUMNK88_1353.UMNK88_3071,iWFL_1372.ECW_m2698,iY75_1357.Y75_RS12925,iYL1228.KPN_02810,iZ_1308.Z3735 Bacteria 1TP11@1239,4H9U8@91061,COG0152@1,COG0152@2 NA|NA|NA F Belongs to the SAICAR synthetase family MIPOCGNA_01212 322159.STER_0048 4.2e-34 150.2 Bacteria acpP1 ko:K02078 ko00000,ko00001 Bacteria COG0236@1,COG0236@2 NA|NA|NA IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis MIPOCGNA_01213 322159.STER_0047 5.1e-179 633.6 Bacilli plsX GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 1TPXS@1239,4HA0R@91061,COG0416@1,COG0416@2 NA|NA|NA I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA MIPOCGNA_01214 322159.STER_0046 1e-142 512.7 Bacilli recO GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 ko:K03584 ko03440,map03440 ko00000,ko00001,ko03400 Bacteria 1UZ19@1239,4HAHI@91061,COG1381@1,COG1381@2 NA|NA|NA L Involved in DNA repair and RecF pathway recombination MIPOCGNA_01215 264199.stu0026 8.5e-218 762.7 Bacilli araT 2.6.1.1 ko:K00812,ko:K00841,ko:K10907 ko00220,ko00250,ko00270,ko00300,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00300,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 M00525 R00355,R00694,R00734,R00896,R02433,R02619,R04467,R05052 RC00006 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 1TP0J@1239,4HA13@91061,COG0436@1,COG0436@2 NA|NA|NA E Aminotransferase MIPOCGNA_01216 264199.stu0025 2.5e-26 124.0 Bacteria Bacteria COG3464@1,COG3464@2 NA|NA|NA MIPOCGNA_01217 264199.stu0023 4.3e-175 620.5 Bacilli prs 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2848 Bacteria 1TQ6Q@1239,4HB61@91061,COG0462@1,COG0462@2 NA|NA|NA F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) MIPOCGNA_01218 322159.STER_0042 4.1e-99 368.6 Bacilli usp 3.5.1.28 ko:K21471,ko:K22409 ko00000,ko01000,ko01002,ko01011 CBM50 Bacteria 1VCXB@1239,4IS6H@91061,COG3883@1,COG3883@2,COG3942@1,COG3942@2 NA|NA|NA S CHAP domain MIPOCGNA_01219 322159.STER_0041 8.2e-88 329.7 Bacteria mreD GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944 ko:K03571 ko00000,ko03036 9.B.157.1 Bacteria COG2891@1,COG2891@2 NA|NA|NA M Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins MIPOCGNA_01220 322159.STER_0040 3.6e-138 497.7 Bacilli mreC GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007163,GO:0008150,GO:0008360,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0030428,GO:0031224,GO:0031226,GO:0042546,GO:0043621,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071554,GO:0071840,GO:0071944,GO:0071963 ko:K03570 ko00000,ko03036 9.B.157.1 Bacteria 1TR1V@1239,4HB0K@91061,COG1792@1,COG1792@2 NA|NA|NA M Involved in formation and maintenance of cell shape MIPOCGNA_01225 322159.STER_1276 2.8e-93 347.8 Bacilli pat 2.3.1.183 ko:K03823 ko00440,ko01130,map00440,map01130 R08871,R08938 RC00004,RC00064 ko00000,ko00001,ko01000 Bacteria 1V6X5@1239,4HIP1@91061,COG1247@1,COG1247@2 NA|NA|NA M acetyltransferase MIPOCGNA_01226 322159.STER_1275 1.7e-78 298.5 Bacteria alkD Bacteria COG4912@1,COG4912@2 NA|NA|NA L Dna alkylation repair MIPOCGNA_01227 322159.STER_1274 3.6e-199 700.7 Bacilli asd 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPC6@1239,4HA9H@91061,COG0136@1,COG0136@2 NA|NA|NA E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate MIPOCGNA_01228 322159.STER_1273 6.6e-173 613.2 Bacilli dapA 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPCK@1239,4H9K9@91061,COG0329@1,COG0329@2 NA|NA|NA E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) MIPOCGNA_01229 264199.stu1296 1.9e-124 451.8 Bacilli rnc GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 Bacteria 1TPGC@1239,4HAWU@91061,COG0571@1,COG0571@2 NA|NA|NA J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism MIPOCGNA_01230 264199.stu1295 0.0 1509.6 Bacilli smc ko:K03529 ko00000,ko03036 Bacteria 1TPJV@1239,4HB89@91061,COG1196@1,COG1196@2 NA|NA|NA D Required for chromosome condensation and partitioning MIPOCGNA_01231 264199.stu1294 9.6e-197 692.6 Bacilli pheS GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1TPFW@1239,4HAVN@91061,COG0016@1,COG0016@2 NA|NA|NA J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily MIPOCGNA_01232 264199.stu1293 9.9e-94 349.4 Bacilli paiA 2.3.1.57 ko:K22441 ko00000,ko01000 Bacteria 1VDFK@1239,4HMHW@91061,COG0454@1,COG0456@2 NA|NA|NA K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases MIPOCGNA_01233 322159.STER_1267 0.0 1537.3 Bacilli pheT GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890,ko:K06878 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iG2583_1286.G2583_2160,iPC815.YPO2428 Bacteria 1TP98@1239,4HAQ9@91061,COG0072@1,COG0072@2,COG0073@1,COG0073@2 NA|NA|NA J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily MIPOCGNA_01235 264199.stu1289 2e-55 221.5 Firmicutes nrdD_1 1.1.98.6,1.17.4.1 ko:K00525,ko:K21636 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024,R11633,R11634,R11635,R11636 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 Bacteria 1TT3U@1239,COG0209@1,COG0209@2 NA|NA|NA F Ribonucleoside-triphosphate reductase MIPOCGNA_01236 322159.STER_1264 7.7e-241 839.3 Bacilli XK27_08130 Bacteria 1TPS5@1239,4HBNK@91061,COG1167@1,COG1167@2 NA|NA|NA K Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs MIPOCGNA_01238 264199.stu1285 2e-86 325.1 Firmicutes Bacteria 1V6QK@1239,COG4720@1,COG4720@2 NA|NA|NA S ECF-type riboflavin transporter, S component MIPOCGNA_01239 264199.stu1284 5.5e-42 176.8 Bacilli pdxK 2.7.1.35 ko:K00868 ko00750,ko01100,map00750,map01100 R00174,R01909,R02493 RC00002,RC00017 ko00000,ko00001,ko01000 Bacteria 1TRCR@1239,4HHME@91061,COG2240@1,COG2240@2 NA|NA|NA H Belongs to the pyridoxine kinase family MIPOCGNA_01240 264199.stu1284 9.3e-87 326.2 Bacilli pdxK 2.7.1.35 ko:K00868 ko00750,ko01100,map00750,map01100 R00174,R01909,R02493 RC00002,RC00017 ko00000,ko00001,ko01000 Bacteria 1TRCR@1239,4HHME@91061,COG2240@1,COG2240@2 NA|NA|NA H Belongs to the pyridoxine kinase family MIPOCGNA_01241 322159.STER_1260 1.5e-10 70.9 Bacilli XK27_01265 ko:K16923 M00582 ko00000,ko00002,ko02000 3.A.1.28 Bacteria 1VC0F@1239,4HMJM@91061,COG4720@1,COG4720@2 NA|NA|NA S ECF-type riboflavin transporter, S component MIPOCGNA_01242 322159.STER_1054 3.8e-94 350.9 Bacilli Bacteria 1VA6K@1239,4HKNU@91061,COG4767@1,COG4767@2 NA|NA|NA V VanZ like family MIPOCGNA_01243 1046629.Ssal_01163 4.4e-33 146.7 Bacilli Bacteria 1UXY8@1239,4HFD9@91061,COG0406@1,COG0406@2 NA|NA|NA G Belongs to the phosphoglycerate mutase family MIPOCGNA_01244 904306.HMPREF9192_1694 8.1e-100 369.8 Bacilli Bacteria 1UXY8@1239,4HFD9@91061,COG0406@1,COG0406@2 NA|NA|NA G Belongs to the phosphoglycerate mutase family MIPOCGNA_01245 322159.STER_1050 1e-196 692.6 Bacilli Bacteria 1TQBF@1239,4HGFS@91061,COG0628@1,COG0628@2 NA|NA|NA S hmm pf01594 MIPOCGNA_01246 264199.stu1067 8.4e-27 125.6 Bacteria bglH 3.2.1.86 ko:K01223 ko00010,ko00500,map00010,map00500 R00839,R05133,R05134 RC00049,RC00171,RC00714 ko00000,ko00001,ko01000 GT1 Bacteria COG2723@1,COG2723@2 NA|NA|NA G beta-glucosidase activity MIPOCGNA_01247 264199.stu1066 7.7e-67 259.6 Bacilli bglH 3.2.1.86 ko:K01223 ko00010,ko00500,map00010,map00500 R00839,R05133,R05134 RC00049,RC00171,RC00714 ko00000,ko00001,ko01000 GT1 Bacteria 1TP19@1239,4HA1W@91061,COG2723@1,COG2723@2 NA|NA|NA G Belongs to the glycosyl hydrolase 1 family MIPOCGNA_01248 264199.stu1065 3.8e-43 180.3 Bacteria bglH 3.2.1.86 ko:K01223 ko00010,ko00500,map00010,map00500 R00839,R05133,R05134 RC00049,RC00171,RC00714 ko00000,ko00001,ko01000 GT1 Bacteria COG2723@1,COG2723@2 NA|NA|NA G beta-glucosidase activity MIPOCGNA_01249 322159.STER_1048 4.9e-39 166.8 Bacilli Bacteria 1VK6K@1239,4HRS5@91061,COG3937@1,COG3937@2 NA|NA|NA S granule-associated protein MIPOCGNA_01250 322159.STER_1047 1.6e-291 1008.1 Bacilli ko:K03688 ko00000 Bacteria 1TPIV@1239,4HBW3@91061,COG0661@1,COG0661@2 NA|NA|NA S unusual protein kinase MIPOCGNA_01251 904306.HMPREF9192_1701 3.4e-29 133.7 Bacilli estA Bacteria 1VHUN@1239,4IPN1@91061,COG2755@1,COG2755@2 NA|NA|NA E Lysophospholipase L1 and related esterases MIPOCGNA_01252 264199.stu1061 5.1e-38 163.3 Bacilli estA Bacteria 1V1B9@1239,4HGED@91061,COG2755@1,COG2755@2 NA|NA|NA E GDSL-like protein MIPOCGNA_01253 322159.STER_1044 4.6e-157 560.5 Bacilli rssA Bacteria 1TQ9W@1239,4HCHJ@91061,COG4667@1,COG4667@2 NA|NA|NA S Phospholipase, patatin family MIPOCGNA_01254 264199.stu1059 4.1e-127 460.7 Bacilli 3.4.16.4 ko:K01286 ko00000,ko01000 Bacteria 1TQN0@1239,4HD0P@91061,COG1686@1,COG1686@2 NA|NA|NA M Belongs to the peptidase S11 family MIPOCGNA_01255 264199.stu1059 3.9e-24 116.7 Bacilli 3.4.16.4 ko:K01286 ko00000,ko01000 Bacteria 1TQN0@1239,4HD0P@91061,COG1686@1,COG1686@2 NA|NA|NA M Belongs to the peptidase S11 family MIPOCGNA_01256 264199.stu1058 5.9e-22 109.4 Bacteria dacA1 3.4.16.4 ko:K01286,ko:K07258 ko00550,ko01100,map00550,map01100 ko00000,ko00001,ko01000,ko01002,ko01011 Bacteria COG1686@1,COG1686@2 NA|NA|NA M Belongs to the peptidase S11 family MIPOCGNA_01257 322159.STER_1042 5.2e-215 753.4 Bacilli yeaB Bacteria 1TSGY@1239,4H9WP@91061,COG0053@1,COG0053@2,COG4994@1,COG4994@2 NA|NA|NA K Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family MIPOCGNA_01258 322159.STER_1041 2.2e-127 461.5 Firmicutes ung GO:0003674,GO:0003824,GO:0004844,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097510,GO:0140097,GO:1901360 3.2.2.27 ko:K03648 ko03410,ko05340,map03410,map05340 ko00000,ko00001,ko01000,ko03400 Bacteria 1TPSN@1239,COG0692@1,COG0692@2 NA|NA|NA L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine MIPOCGNA_01259 264199.stu1054 1.1e-234 818.9 Bacilli pyrC GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPQM@1239,4HA90@91061,COG0044@1,COG0044@2 NA|NA|NA F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily MIPOCGNA_01260 1046629.Ssal_01151 0.0 1136.3 Bacilli Bacteria 1TS3Q@1239,4HF7D@91061,COG4907@1,COG4907@2 NA|NA|NA S the current gene model (or a revised gene model) may contain a frame shift MIPOCGNA_01261 322159.STER_1036 8.6e-184 649.4 Bacilli acoA 1.2.4.1,1.2.4.4 ko:K00161,ko:K11381,ko:K21416 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1TQDG@1239,4HBEA@91061,COG1071@1,COG1071@2 NA|NA|NA C Dehydrogenase E1 component MIPOCGNA_01262 264199.stu1050 3.7e-182 644.0 Bacilli acoB 1.2.4.1,1.2.4.4 ko:K00162,ko:K11381,ko:K21417 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1TP3J@1239,4HAP6@91061,COG0022@1,COG0022@2 NA|NA|NA C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit MIPOCGNA_01274 1198676.SMUGS5_00840 5.3e-11 72.0 Firmicutes Bacteria 1VP0T@1239,2EG8N@1,33A0G@2 NA|NA|NA MIPOCGNA_01282 322159.STER_0095 0.0 2907.1 Bacilli polC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.7.7 ko:K02342,ko:K03763 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 1TPAG@1239,4H9RF@91061,COG2176@1,COG2176@2 NA|NA|NA L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity MIPOCGNA_01283 264199.stu0063 2.1e-235 821.2 Bacilli pepS ko:K19689 ko00000,ko01000,ko01002 Bacteria 1TP65@1239,4H9W8@91061,COG2309@1,COG2309@2 NA|NA|NA E COG2309 Leucyl aminopeptidase (aminopeptidase T) MIPOCGNA_01284 264199.stu0064 1.6e-35 154.8 Bacteria XK27_02060 Bacteria COG2261@1,COG2261@2 NA|NA|NA S Transglycosylase associated protein MIPOCGNA_01285 264199.stu0065 1.3e-54 218.8 Bacteria badR ko:K15973 ko00000,ko03000 Bacteria COG1846@1,COG1846@2 NA|NA|NA K DNA-binding transcription factor activity MIPOCGNA_01286 264199.stu0066 3.5e-97 360.9 Firmicutes ko:K19784 ko00000 Bacteria 1VAI8@1239,COG0431@1,COG0431@2 NA|NA|NA S reductase MIPOCGNA_01287 322159.STER_0101 1.2e-32 145.2 Firmicutes ko:K07497 ko00000 Bacteria 1TQQY@1239,COG2801@1,COG2801@2 NA|NA|NA L Integrase core domain protein MIPOCGNA_01289 1116231.SMA_2094 7.5e-172 609.8 Bacilli yocD 3.4.17.13 ko:K01297 ko00000,ko01000,ko01002,ko01011 Bacteria 1TRBB@1239,4HB1P@91061,COG1619@1,COG1619@2 NA|NA|NA V proteins, homologs of microcin C7 resistance protein MccF MIPOCGNA_01291 264199.stu0073 3.7e-137 494.2 Bacilli rpsB GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02967 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1TPNA@1239,4H9N5@91061,COG0052@1,COG0052@2 NA|NA|NA J Belongs to the universal ribosomal protein uS2 family MIPOCGNA_01292 264199.stu0074 6.6e-182 643.3 Bacilli tsf GO:0001871,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005085,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0019538,GO:0019899,GO:0030246,GO:0030247,GO:0034641,GO:0034645,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051020,GO:0065007,GO:0065009,GO:0071704,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065 ko:K02357 ko00000,ko03012,ko03029 Bacteria 1TPFJ@1239,4HBDV@91061,COG0264@1,COG0264@2 NA|NA|NA J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome MIPOCGNA_01293 322159.STER_0107 9.3e-83 312.8 Bacilli Bacteria 1V3UW@1239,4HPN6@91061,COG2426@1,COG2426@2 NA|NA|NA S Putative small multi-drug export protein MIPOCGNA_01294 264199.stu0076 6.2e-76 290.0 Bacilli ctsR GO:0006950,GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0046688,GO:0050896,GO:0097501,GO:1990169,GO:1990170 ko:K03708 ko00000,ko03000 Bacteria 1VAXT@1239,4HIFT@91061,COG4463@1,COG4463@2 NA|NA|NA K Belongs to the CtsR family MIPOCGNA_01295 264199.stu0077 0.0 1549.6 Bacilli clpC GO:0006950,GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0046688,GO:0050896,GO:0097501,GO:1990169,GO:1990170 ko:K03696 ko01100,map01100 ko00000,ko03110 Bacteria 1TPMU@1239,4HACY@91061,COG0542@1,COG0542@2 NA|NA|NA O Belongs to the ClpA ClpB family MIPOCGNA_01296 1161413.HMPREF1510_1836 4.2e-28 130.2 Firmicutes ko:K07497 ko00000 Bacteria 1TQQY@1239,COG2801@1,COG2801@2 NA|NA|NA L Integrase core domain protein MIPOCGNA_01297 1069533.Sinf_1704 4.3e-186 657.1 Bacilli gap GO:0000166,GO:0002020,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009986,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0019362,GO:0019637,GO:0019674,GO:0019899,GO:0022610,GO:0034641,GO:0036094,GO:0043891,GO:0044237,GO:0044238,GO:0044281,GO:0044403,GO:0044406,GO:0044419,GO:0044424,GO:0044464,GO:0044650,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051287,GO:0051704,GO:0055086,GO:0055114,GO:0071704,GO:0072524,GO:0097159,GO:0140030,GO:0140032,GO:1901265,GO:1901360,GO:1901363,GO:1901564 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 Bacteria 1TNYU@1239,4H9NS@91061,COG0057@1,COG0057@2 NA|NA|NA G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family MIPOCGNA_01298 264199.stu1789 0.0 1357.4 Bacilli fusA GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0030312,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02355 ko00000,ko03012,ko03029 Bacteria 1TPF9@1239,4HAB8@91061,COG0480@1,COG0480@2 NA|NA|NA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome MIPOCGNA_01299 1046629.Ssal_00227 4.3e-80 303.9 Bacilli rpsG GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016020,GO:0016043,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02992 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V1GG@1239,4H9PA@91061,COG0049@1,COG0049@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA MIPOCGNA_01300 1046629.Ssal_00226 5.1e-69 266.9 Bacilli rpsL GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02950 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V1FJ@1239,4HFMZ@91061,COG0048@1,COG0048@2 NA|NA|NA J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit MIPOCGNA_01301 322159.STER_1765 7e-142 510.0 Bacilli purR 2.4.2.7 ko:K00759,ko:K09685 ko00230,ko01100,map00230,map01100 R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko03000,ko04147 Bacteria 1TPN9@1239,4HB8I@91061,COG0503@1,COG0503@2 NA|NA|NA F operon repressor MIPOCGNA_01302 264199.stu1794 3.6e-179 634.0 Bacilli cbf ko:K03698 ko00000,ko01000,ko03019 Bacteria 1TPIU@1239,4HB1M@91061,COG3481@1,COG3481@2 NA|NA|NA S 3'-5' exoribonuclease yhaM MIPOCGNA_01303 264199.stu1795 4.5e-172 610.9 Bacilli rmuC ko:K09760 ko00000 Bacteria 1TPWI@1239,4HE2N@91061,COG1322@1,COG1322@2 NA|NA|NA S RmuC domain protein MIPOCGNA_01304 264199.stu1796 9.2e-118 429.5 Bacilli thiN 2.7.6.2 ko:K00949 ko00730,ko01100,map00730,map01100 R00619 RC00002,RC00017 ko00000,ko00001,ko01000 Bacteria 1VA0W@1239,4HHS1@91061,COG1564@1,COG1564@2 NA|NA|NA H thiamine pyrophosphokinase MIPOCGNA_01305 264199.stu1797 1.1e-118 432.6 Bacilli rpe 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQK8@1239,4H9RW@91061,COG0036@1,COG0036@2 NA|NA|NA G Belongs to the ribulose-phosphate 3-epimerase family MIPOCGNA_01306 264199.stu1798 1.3e-162 578.9 Bacilli rsgA 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 Bacteria 1TPSQ@1239,4HA9W@91061,COG1162@1,COG1162@2 NA|NA|NA G One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit MIPOCGNA_01308 264199.stu1799 8.9e-156 556.2 Bacilli ksgA GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 ko:K02528 R10716 RC00003,RC03257 ko00000,ko01000,ko03009 Bacteria 1TP9W@1239,4HA4R@91061,COG0030@1,COG0030@2 NA|NA|NA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits MIPOCGNA_01309 322159.STER_1773 2.1e-97 361.7 Bacilli rnmV GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043822,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360 3.1.26.8 ko:K05985,ko:K07476 ko00000,ko01000 Bacteria 1V3K3@1239,4HH5Y@91061,COG1658@1,COG1658@2 NA|NA|NA J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step MIPOCGNA_01310 264199.stu1801 4.1e-144 517.3 Bacilli tatD GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575 ko:K03424 ko00000,ko01000 Bacteria 1TNY1@1239,4HA74@91061,COG0084@1,COG0084@2 NA|NA|NA L Hydrolase, tatd MIPOCGNA_01311 264199.stu1802 1.9e-74 285.0 Bacilli yccU GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K06929 ko00000 Bacteria 1V7C7@1239,4HIZT@91061,COG1832@1,COG1832@2 NA|NA|NA S CoA-binding protein MIPOCGNA_01312 264199.stu1803 1.1e-50 205.7 Bacilli trxA ko:K03671 ko04621,ko05418,map04621,map05418 ko00000,ko00001,ko03110 Bacteria 1VA3Y@1239,4HKKX@91061,COG3118@1,COG3118@2 NA|NA|NA O Belongs to the thioredoxin family MIPOCGNA_01313 322159.STER_1196 5.4e-197 693.3 Firmicutes Bacteria 1UEG7@1239,COG3039@1,COG3039@2 NA|NA|NA L transposase, IS4 family MIPOCGNA_01314 264199.stu1804 7.8e-143 513.1 Bacilli Bacteria 1TQSZ@1239,4HCXD@91061,COG2110@1,COG2110@2 NA|NA|NA S Macro domain protein MIPOCGNA_01315 435842.HMPREF0848_01462 1.8e-10 70.5 Bacilli ko:K07107 ko00000,ko01000 Bacteria 1VAGM@1239,4HIVC@91061,COG0824@1,COG0824@2 NA|NA|NA L thioesterase MIPOCGNA_01316 264199.stu1805 2.2e-54 218.0 Bacteria bta 1.8.1.8 ko:K03671,ko:K03672 ko04621,ko05418,map04621,map05418 ko00000,ko00001,ko01000,ko03110 Bacteria COG0526@1,COG0526@2 NA|NA|NA CO cell redox homeostasis MIPOCGNA_01317 1069533.Sinf_0122 3.3e-247 860.5 Bacilli Bacteria 1TWQ0@1239,4HD9K@91061,COG0726@1,COG0726@2 NA|NA|NA G polysaccharide deacetylase MIPOCGNA_01318 888064.HMPREF9088_2327 5.5e-65 253.4 Enterococcaceae dhaL 2.7.1.121 ko:K05879 ko00561,ko01100,map00561,map01100 R01012 RC00015,RC00017 ko00000,ko00001,ko01000 Bacteria 1V4FH@1239,4AZZ9@81852,4HGZY@91061,COG1461@1,COG1461@2 NA|NA|NA G Dihydroxyacetone kinase MIPOCGNA_01319 945021.TEH_22050 2.9e-125 454.5 Enterococcaceae tnp ko:K07498 ko00000 Bacteria 1TTKR@1239,4B14R@81852,4HCB4@91061,COG3316@1,COG3316@2 NA|NA|NA L Transposase IS66 family MIPOCGNA_01320 904306.HMPREF9192_0491 2.8e-224 784.3 Bacilli capA ko:K07282 ko00000 Bacteria 1UZW4@1239,4HBC3@91061,COG2843@1,COG2843@2 NA|NA|NA M Bacterial capsule synthesis protein MIPOCGNA_01321 264199.stu0112 6.1e-39 166.4 Bacilli gcvR ko:K07166 ko00000 Bacteria 1VENW@1239,4HNJ4@91061,COG3830@1,COG3830@2 NA|NA|NA T UPF0237 protein MIPOCGNA_01322 264199.stu0113 3.9e-243 847.0 Bacilli XK27_08635 ko:K09157 ko00000 Bacteria 1TQG8@1239,4HBTU@91061,COG2848@1,COG2848@2 NA|NA|NA S UPF0210 protein MIPOCGNA_01323 322159.STER_0158 2.4e-135 488.0 Bacilli ais Bacteria 1VDCB@1239,4HJ9X@91061,COG0406@1,COG0406@2 NA|NA|NA G Phosphoglycerate mutase MIPOCGNA_01324 322159.STER_0159 7.9e-143 513.1 Bacilli vanY 3.4.17.14 ko:K07260 ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020 M00651 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504 Bacteria 1V1F7@1239,4HBR1@91061,COG1876@1,COG1876@2 NA|NA|NA M D-alanyl-D-alanine carboxypeptidase MIPOCGNA_01325 264199.stu0117 7.2e-101 373.2 Bacteria acmA 3.2.1.17 ko:K01185,ko:K02395 ko00000,ko01000,ko02035 Bacteria COG1705@1,COG1705@2 NA|NA|NA NU amidase activity MIPOCGNA_01326 264199.stu0118 5.4e-195 686.8 Bacilli hrcA GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K03705 ko00000,ko03000 Bacteria 1TQP7@1239,4HAX5@91061,COG1420@1,COG1420@2 NA|NA|NA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons MIPOCGNA_01327 264199.stu0119 1.9e-69 268.9 Bacilli grpE GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009408,GO:0009605,GO:0009628,GO:0009986,GO:0009987,GO:0009991,GO:0016043,GO:0017076,GO:0019904,GO:0022607,GO:0030234,GO:0030246,GO:0030247,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0042802,GO:0042803,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065003,GO:0065007,GO:0065009,GO:0071496,GO:0071840,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065 ko:K03687 ko00000,ko03029,ko03110 Bacteria 1V6G2@1239,4HIRK@91061,COG0576@1,COG0576@2 NA|NA|NA O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ MIPOCGNA_01328 322159.STER_0163 8.4e-281 972.6 Bacilli dnaK GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0009986,GO:0030246,GO:0030247,GO:0044464,GO:0051704,GO:0098630,GO:0098743,GO:2001065 ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 Bacteria 1TP1J@1239,4HA9S@91061,COG0443@1,COG0443@2 NA|NA|NA O Heat shock 70 kDa protein MIPOCGNA_01329 322159.STER_0164 2.8e-181 641.3 Bacilli dnaJ ko:K03686 ko00000,ko03029,ko03110 Bacteria 1TP00@1239,4H9KA@91061,COG0484@1,COG0484@2 NA|NA|NA O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins MIPOCGNA_01330 264199.stu0122 3.2e-138 497.7 Bacilli truA GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 ko:K06173 ko00000,ko01000,ko03016 Bacteria 1TQUY@1239,4HCFI@91061,COG0101@1,COG0101@2 NA|NA|NA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs MIPOCGNA_01331 264199.stu0123 1.4e-136 492.3 Bacilli thiD 2.7.1.35,2.7.1.49,2.7.4.7 ko:K00868,ko:K00941 ko00730,ko00750,ko01100,map00730,map00750,map01100 M00127 R00174,R01909,R02493,R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQ4A@1239,4H9PP@91061,COG0351@1,COG0351@2 NA|NA|NA H phosphomethylpyrimidine kinase MIPOCGNA_01332 1046629.Ssal_02049 3.3e-72 277.7 Bacilli hmpT GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 1VBBN@1239,4HNM0@91061,COG4720@1,COG4720@2 NA|NA|NA S cog cog4720 MIPOCGNA_01333 322159.STER_0762 8.5e-113 412.9 Bacilli sodA GO:0005575,GO:0005576 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 ko00000,ko00001,ko01000 Bacteria 1TPXT@1239,4HA6U@91061,COG0605@1,COG0605@2 NA|NA|NA C radicals which are normally produced within the cells and which are toxic to biological systems MIPOCGNA_01334 264199.stu0719 2.4e-184 651.4 Bacilli holA 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 1TRM0@1239,4HBB4@91061,COG1466@1,COG1466@2 NA|NA|NA L DNA polymerase III delta subunit MIPOCGNA_01335 322159.STER_0760 0.0 1805.0 Bacilli ppc GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008964,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0072350 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 iJN678.ppc,iSFV_1184.SFV_4025 Bacteria 1TQB6@1239,4HCAF@91061,COG2352@1,COG2352@2 NA|NA|NA H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle MIPOCGNA_01336 1046629.Ssal_01392 6.2e-56 223.4 Bacilli Bacteria 1VF26@1239,2DNM7@1,32Y2X@2,4HP82@91061 NA|NA|NA S Domain of unknown function (DUF4430) MIPOCGNA_01337 264199.stu0716 4.2e-75 287.3 Bacilli ko:K16924,ko:K16927 M00582 ko00000,ko00002,ko02000 3.A.1.29,3.A.1.32 Bacteria 1V5GD@1239,4HI8Y@91061,COG4720@1,COG4720@2 NA|NA|NA S Psort location CytoplasmicMembrane, score MIPOCGNA_01338 904306.HMPREF9192_1176 6.4e-133 480.3 Bacilli htpX ko:K03799 M00743 ko00000,ko00002,ko01000,ko01002 Bacteria 1TP23@1239,4HB11@91061,COG0501@1,COG0501@2 NA|NA|NA O Belongs to the peptidase M48B family MIPOCGNA_01339 322159.STER_0756 2.6e-92 344.7 Bacilli lemA ko:K03744 ko00000 Bacteria 1V1G7@1239,4IR1J@91061,COG1704@1,COG1704@2 NA|NA|NA S LemA family MIPOCGNA_01340 264199.stu0713 1.7e-171 608.6 Bacilli spd ko:K15051 ko00000 Bacteria 1TR37@1239,4HK9Z@91061,COG2169@1,COG2169@2 NA|NA|NA F DNA RNA non-specific endonuclease MIPOCGNA_01341 904306.HMPREF9192_1173 2.3e-48 198.0 Bacteria Bacteria COG5464@1,COG5464@2 NA|NA|NA S double-stranded DNA endodeoxyribonuclease activity MIPOCGNA_01342 264199.stu0711 4.3e-305 1053.1 Bacilli hsdM 2.1.1.72 ko:K03427 ko00000,ko01000,ko02048 Bacteria 1TPGZ@1239,4HA1J@91061,COG0286@1,COG0286@2 NA|NA|NA V type I restriction-modification system MIPOCGNA_01343 435842.HMPREF0848_00365 5.6e-130 470.3 Bacilli Bacteria 1V2TW@1239,4HHGA@91061,COG2852@1,COG2852@2 NA|NA|NA S Protein conserved in bacteria MIPOCGNA_01344 264199.stu0709 0.0 1152.9 Bacilli Bacteria 1VTZC@1239,2F066@1,33T9S@2,4HTGQ@91061 NA|NA|NA S KAP family P-loop domain MIPOCGNA_01345 888746.HMPREF9180_1164 2.2e-120 439.1 Bacilli hsdS 3.1.21.3 ko:K01154 ko00000,ko01000,ko02048 Bacteria 1TP5N@1239,4HFAV@91061,COG0732@1,COG0732@2 NA|NA|NA V type I restriction modification DNA specificity domain protein MIPOCGNA_01346 525919.Apre_1447 1.3e-17 97.8 Clostridia Bacteria 1VDHK@1239,24PVF@186801,2CBBI@1,32RT2@2 NA|NA|NA MIPOCGNA_01347 264199.stu0692 3.5e-285 986.9 Bacilli lysS GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1TP2P@1239,4H9X4@91061,COG1190@1,COG1190@2 NA|NA|NA J Belongs to the class-II aminoacyl-tRNA synthetase family MIPOCGNA_01348 322159.STER_0734 1.9e-15 87.4 Bacilli Bacteria 1VWTU@1239,4HX18@91061,COG1388@1,COG1388@2 NA|NA|NA M LysM domain MIPOCGNA_01349 904306.HMPREF9192_1148 2.4e-58 231.9 Bacteria Bacteria COG1388@1,COG1388@2 NA|NA|NA M LysM domain MIPOCGNA_01350 904293.HMPREF9176_0571 3.5e-19 101.3 Bacilli Bacteria 1VVCA@1239,2BXK6@1,33WGZ@2,4HWEI@91061 NA|NA|NA MIPOCGNA_01351 264199.stu0696 6.4e-173 613.2 Bacilli ko:K07025 ko00000 Bacteria 1V5P7@1239,4HHGY@91061,COG1011@1,COG1011@2 NA|NA|NA S hydrolase MIPOCGNA_01352 264199.stu0697 4.3e-115 420.6 Bacilli pgm6 5.4.2.11,5.4.2.12 ko:K01834,ko:K15634 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 Bacteria 1V7EZ@1239,4HJCK@91061,COG0406@1,COG0406@2 NA|NA|NA G Phosphoglycerate mutase MIPOCGNA_01353 264199.stu0698 7.9e-82 309.7 Bacilli ybaK ko:K03976 ko00000,ko01000,ko03016 Bacteria 1V6JF@1239,4HIH1@91061,COG2606@1,COG2606@2 NA|NA|NA S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily MIPOCGNA_01354 264199.stu0699 4.5e-145 520.8 Bacilli XK27_00880 3.5.1.28 ko:K01447,ko:K07273 R04112 RC00064,RC00141 ko00000,ko01000 Bacteria 1V2YH@1239,4HI8U@91061,COG3757@1,COG3757@2 NA|NA|NA M Glycosyl hydrolase, family 25 MIPOCGNA_01355 1123304.AQYA01000028_gene1720 2.7e-27 128.3 Bacteria Bacteria COG2461@1,COG2461@2 NA|NA|NA P Hemerythrin HHE cation binding domain protein MIPOCGNA_01356 322159.STER_0743 2.6e-112 411.4 Bacilli 1.14.14.5 ko:K04091 ko00920,map00920 R07210,R10206 RC01779,RC02556 ko00000,ko00001,ko01000 Bacteria 1VJRB@1239,4ISN7@91061,COG2141@1,COG2141@2 NA|NA|NA C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases MIPOCGNA_01357 904306.HMPREF9192_1160 1.4e-23 114.8 Bacilli MA20_36090 Bacteria 1VEWD@1239,4IQU0@91061,COG1073@1,COG1073@2 NA|NA|NA S Protein of unknown function (DUF2974) MIPOCGNA_01358 1046629.Ssal_01417 2.2e-48 198.4 Bacilli MA20_36090 Bacteria 1VEWD@1239,4IQU0@91061,COG1073@1,COG1073@2 NA|NA|NA S Protein of unknown function (DUF2974) MIPOCGNA_01359 904306.HMPREF9192_1161 7.4e-130 469.9 Bacilli sdh 1.1.1.276,1.1.1.313,1.1.1.381 ko:K05886,ko:K15373,ko:K16066 ko00240,ko00260,ko00430,ko01100,map00240,map00260,map00430,map01100 R02600,R09289,R10851,R10852 RC00087,RC00525,RC03288 ko00000,ko00001,ko01000 Bacteria 1V08N@1239,4IPTJ@91061,COG4221@1,COG4221@2 NA|NA|NA S Belongs to the short-chain dehydrogenases reductases (SDR) family MIPOCGNA_01360 264199.stu0705 0.0 1947.2 Bacilli hsdR 3.1.21.3 ko:K01153 ko00000,ko01000,ko02048 Bacteria 1TP7S@1239,4HB5A@91061,COG0610@1,COG0610@2 NA|NA|NA L Subunit R is required for both nuclease and ATPase activities, but not for modification MIPOCGNA_01361 1139219.I569_01652 9.2e-53 214.2 Bacilli Bacteria 1VYCI@1239,2F998@1,341KD@2,4HXBU@91061 NA|NA|NA MIPOCGNA_01363 638301.HMPREF0444_1312 5.7e-95 353.6 Bacilli Bacteria 1V2YZ@1239,2DBDH@1,2Z8KQ@2,4HK4W@91061 NA|NA|NA MIPOCGNA_01364 936375.HMPREF1152_0495 6e-55 219.9 Clostridiales incertae sedis Bacteria 1V1G4@1239,24G4Y@186801,3WCKV@538999,COG1670@1,COG1670@2 NA|NA|NA J Acetyltransferase (GNAT) domain MIPOCGNA_01365 1116231.SMA_1372 0.0 1112.4 Bacilli Bacteria 1TPBH@1239,4IQFB@91061,COG1961@1,COG1961@2 NA|NA|NA L Recombinase zinc beta ribbon domain MIPOCGNA_01366 1116231.SMA_1373 1.3e-34 151.8 Bacilli Bacteria 1VK84@1239,4HRBT@91061,COG1396@1,COG1396@2 NA|NA|NA K transcriptional MIPOCGNA_01367 1116231.SMA_1374 1.7e-123 448.7 Bacilli ko:K20460,ko:K20461 ko02010,map02010 M00813 ko00000,ko00001,ko00002,ko02000 3.A.1.124.3,3.A.1.124.4,3.A.1.124.5 Bacteria 1V3PM@1239,4HHIJ@91061,COG4200@1,COG4200@2 NA|NA|NA S ABC-2 family transporter protein MIPOCGNA_01368 1116231.SMA_1375 1.6e-129 468.8 Bacilli ko:K20460,ko:K20461 ko02010,map02010 M00813 ko00000,ko00001,ko00002,ko02000 3.A.1.124.3,3.A.1.124.4,3.A.1.124.5 Bacteria 1V5VS@1239,4HH7H@91061,COG4200@1,COG4200@2 NA|NA|NA S ABC-2 family transporter protein MIPOCGNA_01369 1116231.SMA_1376 2e-166 591.7 Bacilli bcrA ko:K20459 ko02010,map02010 M00813 ko00000,ko00001,ko00002,ko02000 3.A.1.124.3,3.A.1.124.4,3.A.1.124.5 Bacteria 1TP4J@1239,4HBGH@91061,COG1131@1,COG1131@2 NA|NA|NA V abc transporter atp-binding protein MIPOCGNA_01370 1116231.SMA_1377 0.0 1248.8 Bacilli ko:K20344 ko02010,ko02024,map02010,map02024 ko00000,ko00001,ko02000 3.A.1.112 Bacteria 1V77J@1239,4HAX2@91061,COG2274@1,COG2274@2 NA|NA|NA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain MIPOCGNA_01371 1116231.SMA_1378 0.0 1823.5 Bacilli lcnDR2 Bacteria 1TS6F@1239,4HCU7@91061,COG4403@1,COG4403@2 NA|NA|NA V Domain of unknown function (DUF4135) MIPOCGNA_01373 762963.HMPREF9056_00805 1.6e-07 61.2 Actinobacteria Bacteria 2ASYV@1,2HMW6@201174,31IEG@2,4D7MX@85005 NA|NA|NA S Type-A lantibiotic MIPOCGNA_01374 264199.stu1598 1.2e-43 182.2 Bacilli yaaK ko:K09747 ko00000 Bacteria 1VA1S@1239,4HKH3@91061,COG0718@1,COG0718@2 NA|NA|NA S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection MIPOCGNA_01375 264199.stu1599 5.1e-47 193.4 Bacilli Bacteria 1VFYX@1239,4HNKT@91061,COG2963@1,COG2963@2 NA|NA|NA L transposase activity MIPOCGNA_01376 904306.HMPREF9192_0780 6e-121 440.3 Bacilli Bacteria 1UZ0H@1239,4HGGU@91061,COG0789@1,COG0789@2 NA|NA|NA K transcriptional regulator, MerR family MIPOCGNA_01377 264199.stu1601 1.3e-102 379.0 Bacilli dnaQ 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 1V8EQ@1239,4HJYT@91061,COG0847@1,COG0847@2 NA|NA|NA L DNA polymerase III MIPOCGNA_01378 264199.stu1602 9.1e-42 176.8 Bacilli WQ51_02910 Bacteria 1VNC1@1239,2EHT6@1,33BIW@2,4HRJ5@91061 NA|NA|NA S Protein of unknown function, DUF536 MIPOCGNA_01379 264199.stu1603 4.8e-63 246.9 Bacilli XK27_02560 ko:K02612 ko00360,ko01120,map00360,map01120 R09838 RC02690 ko00000,ko00001 Bacteria 1VX9Z@1239,4HXCM@91061,COG2151@1,COG2151@2 NA|NA|NA S cog cog2151 MIPOCGNA_01380 264199.stu1604 0.0 1133.6 Bacilli ilvD GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP1R@1239,4H9ZG@91061,COG0129@1,COG0129@2 NA|NA|NA E Belongs to the IlvD Edd family MIPOCGNA_01381 264199.stu1605 1e-226 792.3 Bacilli ytfP ko:K07007 ko00000 Bacteria 1TQ6E@1239,4HAAT@91061,COG2081@1,COG2081@2 NA|NA|NA S Flavoprotein MIPOCGNA_01383 264199.stu1606 3.4e-120 437.6 Bacilli trmB GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.297,2.1.1.33 ko:K02493,ko:K03439 R10806 RC00003,RC03279 ko00000,ko01000,ko03012,ko03016 Bacteria 1TQCA@1239,4HC08@91061,COG0220@1,COG0220@2 NA|NA|NA J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA MIPOCGNA_01384 264199.stu1607 1.2e-151 542.3 Bacilli ytmP 2.7.1.89 ko:K07251 ko00730,ko01100,map00730,map01100 R02134 RC00002,RC00017 ko00000,ko00001,ko01000 Bacteria 1UMFY@1239,4HBF9@91061,COG0510@1,COG0510@2 NA|NA|NA M Phosphotransferase MIPOCGNA_01385 322159.STER_1571 4.3e-181 640.6 Bacilli ecsB ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1V1VG@1239,4HG1K@91061,COG4473@1,COG4473@2 NA|NA|NA U ABC transporter MIPOCGNA_01386 264199.stu1609 1.1e-130 472.6 Bacilli ecsA ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TQIH@1239,4HA2B@91061,COG1131@1,COG1131@2 NA|NA|NA V abc transporter atp-binding protein MIPOCGNA_01387 322159.STER_1573 2.5e-71 274.6 Bacilli hit ko:K02503 ko00000,ko04147 Bacteria 1V9ZJ@1239,4HIG2@91061,COG0537@1,COG0537@2 NA|NA|NA FG Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases MIPOCGNA_01388 1000588.HMPREF9965_1970 1.9e-09 68.6 Streptococcus mitis Bacteria 1U4H8@1239,2DKCI@1,2TPVV@28037,30963@2,4IE92@91061 NA|NA|NA MIPOCGNA_01390 435842.HMPREF0848_01249 6.9e-19 100.1 Bacilli Bacteria 1VI51@1239,2E9BR@1,333JH@2,4HQRQ@91061 NA|NA|NA MIPOCGNA_01391 1008453.HMPREF9957_0290 6.3e-07 60.8 Streptococcus mitis Bacteria 1UD5G@1239,2DIAX@1,2TNYQ@28037,302KA@2,4IE19@91061 NA|NA|NA MIPOCGNA_01392 435842.HMPREF0848_01592 4.4e-56 223.8 Bacilli comA ko:K06147,ko:K06148,ko:K20344 ko02010,ko02024,map02010,map02024 ko00000,ko00001,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.112,3.A.1.21 Bacteria 1V77J@1239,4HAX2@91061,COG2274@1,COG2274@2 NA|NA|NA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain MIPOCGNA_01393 264199.stu0272 5.5e-105 387.1 Bacilli GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0071702 ko:K06147,ko:K06148,ko:K20344 ko02010,ko02024,map02010,map02024 ko00000,ko00001,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.112,3.A.1.21 Bacteria 1V77J@1239,4HAX2@91061,COG2274@1,COG2274@2 NA|NA|NA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain MIPOCGNA_01394 264199.stu0271 2.1e-32 144.4 Bacteria GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0071702 ko:K06147,ko:K06148,ko:K20344 ko02010,ko02024,map02010,map02024 ko00000,ko00001,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.112,3.A.1.21 Bacteria COG2274@1,COG2274@2 NA|NA|NA V protein secretion by the type I secretion system MIPOCGNA_01395 264199.stu0270 5.6e-161 573.5 Bacteria ko:K20342,ko:K20480 ko02024,map02024 ko00000,ko00001,ko03000 Bacteria COG1396@1,COG1396@2 NA|NA|NA K sequence-specific DNA binding MIPOCGNA_01396 322159.STER_0315 6.5e-111 406.8 Bacilli bcrC 3.6.1.27 ko:K19302 ko00550,map00550 R05627 RC00002 ko00000,ko00001,ko01000,ko01011 Bacteria 1VF2U@1239,4HNXR@91061,COG0671@1,COG0671@2 NA|NA|NA I Membrane-associated phospholipid phosphatase MIPOCGNA_01397 322159.STER_0314 6.4e-91 340.1 Bacilli ribU GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015238,GO:0015711,GO:0015893,GO:0016020,GO:0022857,GO:0032217,GO:0032218,GO:0034220,GO:0035461,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051180,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0090482,GO:0098656 Bacteria 1V4BW@1239,4HHFT@91061,COG3601@1,COG3601@2 NA|NA|NA U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins MIPOCGNA_01398 264199.stu0267 1.6e-96 358.6 Bacilli trmL GO:0001510,GO:0002128,GO:0002130,GO:0002131,GO:0002132,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.207 ko:K03216 ko00000,ko01000,ko03016 Bacteria 1V3GW@1239,4HFNY@91061,COG0219@1,COG0219@2 NA|NA|NA J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily MIPOCGNA_01399 264199.stu0265 1.4e-245 855.1 Bacilli trkA ko:K03499 ko00000,ko02000 2.A.38.1,2.A.38.4 Bacteria 1TPNS@1239,4HCRM@91061,COG0569@1,COG0569@2 NA|NA|NA P Potassium transporter peripheral membrane component MIPOCGNA_01400 264199.stu0264 1.4e-254 885.2 Bacilli trkH GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005267,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0022803,GO:0022838,GO:0022857,GO:0022890,GO:0030001,GO:0030955,GO:0031224,GO:0031226,GO:0031420,GO:0034220,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046983,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662 ko:K03498,ko:K03499 ko00000,ko02000 2.A.38.1,2.A.38.4 iECDH1ME8569_1439.ECDH1ME8569_1308,iPC815.YPO3762,iSFV_1184.SFV_3651 Bacteria 1TPAF@1239,4HCWN@91061,COG0168@1,COG0168@2 NA|NA|NA P Cation transport protein MIPOCGNA_01401 264199.stu0263 8e-41 172.6 Bacilli yidD ko:K08998 ko00000 Bacteria 1VEIG@1239,4HPA3@91061,COG0759@1,COG0759@2 NA|NA|NA S Could be involved in insertion of integral membrane proteins into the membrane MIPOCGNA_01402 264199.stu0262 1.6e-140 505.4 Bacilli rluB GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.19,5.4.99.21,5.4.99.22 ko:K06178,ko:K06182,ko:K06183 ko00000,ko01000,ko03009 Bacteria 1TP68@1239,4H9MU@91061,COG1187@1,COG1187@2 NA|NA|NA J Belongs to the pseudouridine synthase RsuA family MIPOCGNA_01403 264199.stu0261 3e-99 367.9 Bacilli scpB GO:0003674,GO:0005488,GO:0005515,GO:0042802 ko:K06024 ko00000,ko03036 Bacteria 1V6HI@1239,4HIQ0@91061,COG1386@1,COG1386@2 NA|NA|NA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves MIPOCGNA_01404 264199.stu0260 1.5e-121 442.2 Bacilli scpA GO:0003674,GO:0005488,GO:0005515,GO:0042802 ko:K05896 ko00000,ko03036 Bacteria 1V8JV@1239,4IQZ5@91061,COG1354@1,COG1354@2 NA|NA|NA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves MIPOCGNA_01405 264199.stu0259 2.8e-137 494.6 Bacilli xerD ko:K04763 ko00000,ko03036 Bacteria 1VY7C@1239,4IT0W@91061,COG4974@1,COG4974@2 NA|NA|NA L tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site MIPOCGNA_01406 322159.STER_0305 2.7e-85 321.2 Bacilli ykuL Bacteria 1VFAB@1239,4HRWJ@91061,COG0517@1,COG0517@2 NA|NA|NA S CBS domain MIPOCGNA_01407 264199.stu0257 1.7e-98 365.2 Bacilli XK27_09740 ko:K07095 ko00000 Bacteria 1VA0U@1239,4HM24@91061,COG0622@1,COG0622@2 NA|NA|NA S Phosphoesterase MIPOCGNA_01408 264199.stu0256 8.7e-184 649.4 Bacilli rdgB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66,5.1.1.3 ko:K01776,ko:K02428 ko00230,ko00471,ko01100,map00230,map00471,map01100 R00260,R00426,R00720,R01855,R02100,R02720,R03531 RC00002,RC00302 ko00000,ko00001,ko01000,ko01011 Bacteria 1V6RN@1239,4HCP6@91061,COG0127@1,COG0127@2 NA|NA|NA F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions MIPOCGNA_01409 322159.STER_0302 1.9e-147 528.5 Bacilli murI GO:0000270,GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008657,GO:0008881,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010911,GO:0016020,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0030234,GO:0032780,GO:0034645,GO:0036361,GO:0042030,GO:0042546,GO:0042802,GO:0043086,GO:0043170,GO:0043462,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0047661,GO:0050790,GO:0051336,GO:0051346,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0072586,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:2000371,GO:2000372 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 R00260 RC00302 ko00000,ko00001,ko01000,ko01011 iYO844.BSU28390 Bacteria 1TPPR@1239,4HA46@91061,COG0796@1,COG0796@2 NA|NA|NA M Provides the (R)-glutamate required for cell wall biosynthesis MIPOCGNA_01410 264199.stu0254 7.6e-36 156.0 Bacilli yneF ko:K09976 ko00000 Bacteria 1VDSU@1239,4HM8G@91061,COG3763@1,COG3763@2 NA|NA|NA S UPF0154 protein MIPOCGNA_01411 322159.STER_0300 4.5e-89 334.0 Bacteria Bacteria COG1309@1,COG1309@2 NA|NA|NA K transcriptional regulator MIPOCGNA_01412 264199.stu0252 8.1e-243 845.9 Bacilli lysA 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPE9@1239,4H9XW@91061,COG0019@1,COG0019@2 NA|NA|NA E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine MIPOCGNA_01415 322159.STER_0296 2.9e-93 348.2 Bacilli ybhL GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K06890 ko00000 Bacteria 1V779@1239,4HIX1@91061,COG0670@1,COG0670@2 NA|NA|NA S Belongs to the BI1 family MIPOCGNA_01416 322159.STER_0295 4.7e-93 347.1 Bacilli XK27_09705 6.1.1.14 ko:K01879,ko:K06950 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1V4QX@1239,4HHW0@91061,COG1418@1,COG1418@2 NA|NA|NA S HD superfamily hydrolase MIPOCGNA_01417 264199.stu0247 6.4e-131 473.4 Bacilli spoU 2.1.1.185 ko:K03218,ko:K03437 ko00000,ko01000,ko03009,ko03016 Bacteria 1V3JP@1239,4HCF5@91061,COG0566@1,COG0566@2 NA|NA|NA J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family MIPOCGNA_01418 264199.stu0246 6e-45 186.4 Bacteria acyP GO:0003674,GO:0003824,GO:0003998,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016787,GO:0016817,GO:0016818,GO:0050896 3.6.1.7 ko:K01512 ko00620,ko00627,ko01120,map00620,map00627,map01120 R00317,R01421,R01515 RC00043 ko00000,ko00001,ko01000 iSB619.SA_RS07020,iSBO_1134.SBO_2263,iSF_1195.SF0969,iSFxv_1172.SFxv_1053,iS_1188.S1036 Bacteria COG1254@1,COG1254@2 NA|NA|NA C Belongs to the acylphosphatase family MIPOCGNA_01419 264199.stu0245 2.9e-165 587.8 Bacilli yidC ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 Bacteria 1TSDN@1239,4HCC8@91061,COG0706@1,COG0706@2 NA|NA|NA U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins MIPOCGNA_01420 322159.STER_0291 2.6e-88 331.3 Firmicutes ko:K07497 ko00000 Bacteria 1TQQY@1239,COG2801@1,COG2801@2 NA|NA|NA L Integrase core domain protein MIPOCGNA_01421 322159.STER_0289 1.6e-77 295.4 Bacilli greA GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 ko:K03624 ko00000,ko03021 Bacteria 1V44S@1239,4HGZU@91061,COG0782@1,COG0782@2 NA|NA|NA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides MIPOCGNA_01422 322159.STER_0288 0.0 1189.1 Bacilli mltG ko:K07082 ko00000 Bacteria 1TS48@1239,4HAUV@91061,COG1559@1,COG1559@2 NA|NA|NA ADL Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation MIPOCGNA_01423 264199.stu0240 3.3e-80 304.3 Bacteria XK27_09675 ko:K07105 ko00000 Bacteria COG0454@1,COG0454@2 NA|NA|NA K -acetyltransferase MIPOCGNA_01424 264199.stu0239 2.6e-255 887.5 Bacilli mpl GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0016874,GO:0016879,GO:0016881,GO:0042802,GO:0044424,GO:0044464 6.3.2.4,6.3.2.45,6.3.2.8 ko:K01921,ko:K01924,ko:K02558 ko00471,ko00473,ko00550,ko01100,ko01502,map00471,map00473,map00550,map01100,map01502 R01150,R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 iSDY_1059.SDY_4251 Bacteria 1TQ5H@1239,4HAR4@91061,COG0773@1,COG0773@2 NA|NA|NA M Belongs to the MurCDEF family MIPOCGNA_01425 40041.SZO_03140 2.5e-23 115.9 Streptococcus dysgalactiae group Bacteria 1M9KI@119603,1TXB8@1239,2DJ6Z@1,304WH@2,4I68V@91061 NA|NA|NA MIPOCGNA_01426 322159.STER_0284 0.0 2030.4 Bacilli snf 2.7.11.1 ko:K08282 ko00000,ko01000 Bacteria 1TPFZ@1239,4HAIF@91061,COG0553@1,COG0553@2 NA|NA|NA L Superfamily II DNA RNA helicases, SNF2 family' MIPOCGNA_01427 322159.STER_0283 1.7e-305 1054.7 Bacilli mapZ ko:K20073 ko00000 Bacteria 1VDPS@1239,2DB6P@1,32TWV@2,4HK8Y@91061 NA|NA|NA D Early cell division protein that marks the future cell division site and supports proper FtsZ ring positioning MIPOCGNA_01428 264199.stu0234 1.9e-222 778.1 Bacilli rlmL GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016423,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.173,2.1.1.264 ko:K07444,ko:K12297 R07234 RC00003 ko00000,ko01000,ko03009 Bacteria 1TP0X@1239,4HBKY@91061,COG0116@1,COG0116@2 NA|NA|NA L Belongs to the methyltransferase superfamily MIPOCGNA_01429 264199.stu0233 7.3e-50 203.0 Bacilli gpsB ko:K04074 ko00000,ko03036 Bacteria 1VEQ4@1239,4HKUX@91061,COG3599@1,COG3599@2 NA|NA|NA D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation MIPOCGNA_01430 322159.STER_0279 3.1e-95 354.4 Bacilli ypsA Bacteria 1V5Q7@1239,4HECZ@91061,COG4474@1,COG4474@2 NA|NA|NA S Belongs to the UPF0398 family MIPOCGNA_01431 264199.stu0231 2.5e-109 401.4 Bacilli recU GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 ko:K03700 ko00000,ko03400 Bacteria 1V3S4@1239,4HGZ7@91061,COG3331@1,COG3331@2 NA|NA|NA L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation MIPOCGNA_01432 322159.STER_0277 0.0 1393.6 Bacilli ponA GO:0005575,GO:0005576 2.4.1.129,3.4.16.4 ko:K03693,ko:K05365,ko:K05366,ko:K12555,ko:K21464 ko00550,ko01100,ko01501,map00550,map01100,map01501 R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 GT51 Bacteria 1TPM5@1239,4H9SA@91061,COG0744@1,COG0744@2 NA|NA|NA M penicillin-binding protein MIPOCGNA_01433 1046629.Ssal_01946 5.4e-253 879.8 Bacilli pepC GO:0000096,GO:0000098,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006508,GO:0006520,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0009056,GO:0009063,GO:0009636,GO:0009987,GO:0016054,GO:0016787,GO:0019538,GO:0019752,GO:0042221,GO:0043170,GO:0043418,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0050667,GO:0050896,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.4.22.40 ko:K01372 ko00000,ko01000,ko01002 Bacteria 1TRJN@1239,4HBZ9@91061,COG3579@1,COG3579@2 NA|NA|NA E aminopeptidase MIPOCGNA_01434 264199.stu0228 1.1e-69 269.2 Bacteria yhaI Bacteria COG3152@1,COG3152@2 NA|NA|NA L Membrane MIPOCGNA_01435 264199.stu0227 2.1e-151 541.6 Bacilli nadE GO:0003674,GO:0003824,GO:0003952,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0016884,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0033554,GO:0034355,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043094,GO:0043173,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.1.5 ko:K01916 ko00760,ko01100,map00760,map01100 M00115 R00189 RC00100 ko00000,ko00001,ko00002,ko01000 iECSE_1348.ECSE_1910,iECW_1372.ECW_m1909,iEKO11_1354.EKO11_2035,iETEC_1333.ETEC_1772,iEcE24377_1341.EcE24377A_1961,iSFV_1184.SFV_1480,iSF_1195.SF1486,iSFxv_1172.SFxv_1676,iSSON_1240.SSON_1418,iS_1188.S1603,iWFL_1372.ECW_m1909 Bacteria 1TQ38@1239,4HA2R@91061,COG0171@1,COG0171@2 NA|NA|NA H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source MIPOCGNA_01436 264199.stu0226 2.7e-274 950.7 Bacilli pncB GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.21 ko:K00763 ko00760,ko01100,map00760,map01100 R01724 RC00033 ko00000,ko00001,ko01000 iYO844.BSU31750 Bacteria 1TPDW@1239,4HAI4@91061,COG1488@1,COG1488@2 NA|NA|NA H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP MIPOCGNA_01437 1046629.Ssal_01959 2.2e-232 811.2 Bacilli ko:K06889 ko00000 Bacteria 1V38K@1239,4HE7V@91061,COG1073@1,COG1073@2 NA|NA|NA S COG1073 Hydrolases of the alpha beta superfamily MIPOCGNA_01438 1046629.Ssal_01960 3.5e-71 274.2 Bacilli Bacteria 1V1U2@1239,4HI88@91061,COG1846@1,COG1846@2 NA|NA|NA K transcriptional MIPOCGNA_01439 264199.stu0220 0.0 1707.6 Bacilli leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Bacteria 1TP0Y@1239,4HAG1@91061,COG0495@1,COG0495@2 NA|NA|NA J Belongs to the class-I aminoacyl-tRNA synthetase family MIPOCGNA_01440 264199.stu0219 1.9e-98 365.2 Bacilli glcR ko:K02444,ko:K22103 ko00000,ko03000 Bacteria 1V6VV@1239,4HK1E@91061,COG1349@1,COG1349@2 NA|NA|NA K transcriptional regulator (DeoR family) MIPOCGNA_01441 264199.stu0218 2.1e-35 154.5 Bacteria cof Bacteria COG0561@1,COG0561@2 NA|NA|NA Q phosphatase activity MIPOCGNA_01442 264199.stu0217 4e-47 193.7 Bacteria cof Bacteria COG0561@1,COG0561@2 NA|NA|NA Q phosphatase activity MIPOCGNA_01443 264199.stu0216 4.6e-85 320.5 Bacteria 3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27 ko:K01096,ko:K19302 ko00550,ko00564,ko01100,map00550,map00564,map01100 R02029,R05627 RC00002,RC00017 ko00000,ko00001,ko01000,ko01011 Bacteria COG0671@1,COG0671@2 NA|NA|NA I phosphatidate phosphatase activity MIPOCGNA_01444 1046629.Ssal_01967 8.4e-96 356.3 Bacilli nusG GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 ko:K02601 ko00000,ko03009,ko03021 Bacteria 1TR3P@1239,4HAJA@91061,COG0250@1,COG0250@2 NA|NA|NA K Participates in transcription elongation, termination and antitermination MIPOCGNA_01445 904306.HMPREF9192_0204 2.2e-24 117.5 Firmicutes secE GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K03073 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 Bacteria 1W4QH@1239,COG0690@1,COG0690@2 NA|NA|NA U Belongs to the SecE SEC61-gamma family MIPOCGNA_01446 264199.stu0212 0.0 1503.4 Bacilli pbp2A 2.4.1.129,3.4.16.4 ko:K03693,ko:K05365,ko:K05366,ko:K12555,ko:K21464 ko00550,ko01100,ko01501,map00550,map01100,map01501 R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 GT51 Bacteria 1TPM5@1239,4H9SA@91061,COG0744@1,COG0744@2 NA|NA|NA M penicillin-binding protein MIPOCGNA_01447 264199.stu0211 3.1e-164 584.3 Bacilli rluA GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 ko:K06180 ko00000,ko01000,ko03009 Bacteria 1TSM6@1239,4HA7M@91061,COG0564@1,COG0564@2 NA|NA|NA J Responsible for synthesis of pseudouridine from uracil MIPOCGNA_01448 322159.STER_0258 1.7e-54 218.4 Bacilli Bacteria 1VKEZ@1239,4HS74@91061,COG2314@1,COG2314@2 NA|NA|NA S TM2 domain MIPOCGNA_01449 435842.HMPREF0848_01529 5.3e-16 89.4 Bacteria Bacteria 2C0H5@1,2ZRTJ@2 NA|NA|NA MIPOCGNA_01452 264199.stu0207 1.3e-31 141.7 Firmicutes ko:K07497 ko00000 Bacteria 1TQQY@1239,COG2801@1,COG2801@2 NA|NA|NA L Integrase core domain protein MIPOCGNA_01453 264199.stu0206 1e-51 209.5 Bacteria ko:K07497 ko00000 Bacteria COG2801@1,COG2801@2 NA|NA|NA L transposition MIPOCGNA_01454 322159.STER_0055 2.2e-73 281.6 Bacteria ko:K07483 ko00000 Bacteria COG2963@1,COG2963@2 NA|NA|NA L transposase activity MIPOCGNA_01455 264199.stu0204 2.5e-284 984.2 Bacilli groL GO:0001817,GO:0001819,GO:0001871,GO:0002791,GO:0002793,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009986,GO:0009987,GO:0016465,GO:0030246,GO:0030247,GO:0032677,GO:0032757,GO:0032879,GO:0032880,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044764,GO:0046812,GO:0048518,GO:0048522,GO:0050707,GO:0050708,GO:0050714,GO:0050715,GO:0050789,GO:0050794,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051082,GO:0051222,GO:0051223,GO:0051239,GO:0051240,GO:0051704,GO:0061077,GO:0065007,GO:0070201,GO:0090087,GO:0098630,GO:0098743,GO:0101031,GO:1903530,GO:1903532,GO:1904951,GO:1990220,GO:2000482,GO:2000484,GO:2001065 ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 Bacteria 1TP1T@1239,4HA38@91061,COG0459@1,COG0459@2 NA|NA|NA O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions MIPOCGNA_01456 264199.stu0203 1e-39 169.1 Bacteria groS GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010468,GO:0010556,GO:0016020,GO:0016032,GO:0016465,GO:0019058,GO:0019068,GO:0019219,GO:0019222,GO:0019899,GO:0030312,GO:0031323,GO:0031326,GO:0032991,GO:0033554,GO:0034605,GO:0035375,GO:0035966,GO:0040007,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046677,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051704,GO:0051716,GO:0060255,GO:0061077,GO:0065007,GO:0071944,GO:0080090,GO:0101031,GO:1903506,GO:1990220,GO:2000112,GO:2001141 ko:K04078 ko00000,ko03029,ko03110 Bacteria COG0234@1,COG0234@2 NA|NA|NA O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter MIPOCGNA_01457 1046629.Ssal_01977 1.3e-140 505.8 Bacilli cmpC ko:K05833 M00247 ko00000,ko00002,ko02000 Bacteria 1TPAN@1239,4HCHC@91061,COG1101@1,COG1101@2 NA|NA|NA S abc transporter atp-binding protein MIPOCGNA_01458 264199.stu0201 0.0 1132.9 Firmicutes WQ51_06230 ko:K01989,ko:K05832 M00247 ko00000,ko00002,ko02000 Bacteria 1TPB0@1239,COG2984@1,COG2984@2,COG4120@1,COG4120@2 NA|NA|NA S ABC transporter substrate binding protein MIPOCGNA_01459 264199.stu0200 0.0 1206.8 Bacilli proS GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0043906,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iJN678.proS,iUTI89_1310.UTI89_C0210 Bacteria 1TRBV@1239,4H9NN@91061,COG0442@1,COG0442@2 NA|NA|NA J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS MIPOCGNA_01460 322159.STER_0246 1e-229 802.4 Bacilli rseP GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016021,GO:0016787,GO:0019219,GO:0019222,GO:0019538,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0040007,GO:0043170,GO:0043856,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0045152,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:0140110,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 3.4.21.107,3.4.21.116 ko:K04771,ko:K06399,ko:K11749,ko:K16922 ko01503,ko02020,ko02024,ko04112,map01503,map02020,map02024,map04112 M00728 ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 Bacteria 1TPMC@1239,4HAQ5@91061,COG0750@1,COG0750@2 NA|NA|NA M zinc metalloprotease MIPOCGNA_01461 264199.stu0198 5e-145 520.4 Bacilli cdsA GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS06255 Bacteria 1TT0Q@1239,4HAMN@91061,COG4589@1,COG4589@2 NA|NA|NA S Belongs to the CDS family MIPOCGNA_01462 264199.stu0197 2.4e-141 508.1 Bacilli uppS GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 Bacteria 1TQTS@1239,4HA37@91061,COG0020@1,COG0020@2 NA|NA|NA H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids MIPOCGNA_01463 264199.stu0196 9.8e-50 202.6 Bacteria yajC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031522,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 Bacteria COG1862@1,COG1862@2 NA|NA|NA U protein transport MIPOCGNA_01464 264199.stu0195 1.2e-126 459.1 Bacilli yeeN GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 Bacteria 1TPP5@1239,4H9WJ@91061,COG0217@1,COG0217@2 NA|NA|NA K transcriptional regulatory protein MIPOCGNA_01465 264199.stu0194 3.4e-255 887.1 Bacilli pgi GO:0003674,GO:0003824,GO:0004347,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 iLJ478.TM1385 Bacteria 1TP29@1239,4H9VI@91061,COG0166@1,COG0166@2 NA|NA|NA G Belongs to the GPI family MIPOCGNA_01466 264199.stu0193 9.8e-157 559.3 Bacilli rgfB 3.1.3.90 ko:K06896 ko00500,map00500 R10486 RC00017 ko00000,ko00001,ko01000 Bacteria 1TQZG@1239,4HGS5@91061,COG3568@1,COG3568@2 NA|NA|NA L Endonuclease/Exonuclease/phosphatase family MIPOCGNA_01467 435842.HMPREF0848_01513 4.2e-257 893.6 Bacilli ptsG 2.7.1.199,2.7.1.208 ko:K02777,ko:K02778,ko:K02779,ko:K20107,ko:K20108 ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111 M00265,M00266,M00268,M00270,M00272,M00303,M00806 R02738,R02780,R04111,R04394,R05132,R08559 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.1,4.A.1.1.11,4.A.1.1.12 Bacteria 1TPJ8@1239,4HA8X@91061,COG1263@1,COG1263@2,COG1264@1,COG1264@2,COG2190@1,COG2190@2 NA|NA|NA G pts system MIPOCGNA_01468 435842.HMPREF0848_01513 9.2e-25 119.0 Bacilli ptsG 2.7.1.199,2.7.1.208 ko:K02777,ko:K02778,ko:K02779,ko:K20107,ko:K20108 ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111 M00265,M00266,M00268,M00270,M00272,M00303,M00806 R02738,R02780,R04111,R04394,R05132,R08559 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.1,4.A.1.1.11,4.A.1.1.12 Bacteria 1TPJ8@1239,4HA8X@91061,COG1263@1,COG1263@2,COG1264@1,COG1264@2,COG2190@1,COG2190@2 NA|NA|NA G pts system MIPOCGNA_01469 264199.stu0189 1.3e-64 252.3 Bacilli ptsG 2.7.1.199,2.7.1.208 ko:K02777,ko:K02778,ko:K02779,ko:K20107,ko:K20108 ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111 M00265,M00266,M00268,M00270,M00272,M00303,M00806 R02738,R02780,R04111,R04394,R05132,R08559 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.1,4.A.1.1.11,4.A.1.1.12 Bacteria 1TPJ8@1239,4HA8X@91061,COG1263@1,COG1263@2 NA|NA|NA G pts system MIPOCGNA_01470 264199.stu0188 2.1e-163 581.6 Bacilli mleP2 ko:K07088 ko00000 Bacteria 1UY4N@1239,4HB48@91061,COG0679@1,COG0679@2 NA|NA|NA S Transporter, auxin efflux carrier (AEC) family protein MIPOCGNA_01471 322159.STER_0235 1.9e-128 465.3 Bacilli adcB GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0010035,GO:0010038,GO:0010043,GO:0016020,GO:0042221,GO:0044464,GO:0050896,GO:0071944 ko:K09816 ko02010,map02010 M00242 ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 Bacteria 1TR79@1239,4HC3C@91061,COG1108@1,COG1108@2 NA|NA|NA P ABC transporter (Permease MIPOCGNA_01472 264199.stu0186 2.2e-136 491.5 Bacilli adcC ko:K09817 ko02010,map02010 M00242 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15.3,3.A.1.15.5 iHN637.CLJU_RS15665,iYO844.BSU02860 Bacteria 1TQ68@1239,4HAZI@91061,COG1121@1,COG1121@2 NA|NA|NA P ABC transporter, ATP-binding protein MIPOCGNA_01473 264199.stu0185 3.1e-72 277.7 Bacilli adcR Bacteria 1VXZT@1239,4HXMU@91061,COG1846@1,COG1846@2 NA|NA|NA K transcriptional MIPOCGNA_01474 264199.stu0184 1.9e-223 781.6 Bacilli Bacteria 1UG5D@1239,2ZBIK@2,4H9W5@91061,COG0477@1 NA|NA|NA EGP Major facilitator Superfamily MIPOCGNA_01475 264199.stu0183 0.0 1171.0 Bacilli Bacteria 1V7E2@1239,4HJ1U@91061,COG0515@1,COG0515@2 NA|NA|NA KLT serine threonine protein kinase MIPOCGNA_01476 264199.stu0183 1.5e-106 392.1 Bacilli Bacteria 1V7E2@1239,4HJ1U@91061,COG0515@1,COG0515@2 NA|NA|NA KLT serine threonine protein kinase MIPOCGNA_01477 264199.stu0182 6e-128 463.8 Bacteria ko:K20374,ko:K21405 ko02024,map02024 ko00000,ko00001,ko03000 Bacteria COG1396@1,COG1396@2 NA|NA|NA K sequence-specific DNA binding MIPOCGNA_01478 322159.STER_0231 1.3e-182 645.6 Bacilli dus ko:K05540 ko00000,ko01000,ko03016 Bacteria 1TQ2R@1239,4HA9K@91061,COG0042@1,COG0042@2 NA|NA|NA J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines MIPOCGNA_01479 322159.STER_0230 5.6e-158 563.5 Bacilli hslO GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0031647,GO:0036506,GO:0042026,GO:0042802,GO:0043167,GO:0043169,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0065007,GO:0065008 ko:K04083 ko00000,ko03110 Bacteria 1TRCH@1239,4HAFR@91061,COG1281@1,COG1281@2 NA|NA|NA O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress MIPOCGNA_01481 435842.HMPREF0848_01505 8.1e-163 579.7 Bacilli oppF ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 1V36J@1239,4H9YB@91061,COG4608@1,COG4608@2 NA|NA|NA P Belongs to the ABC transporter superfamily MIPOCGNA_01482 435842.HMPREF0848_01504 7.3e-189 666.4 Bacilli oppD ko:K02031,ko:K02032,ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 1TP6E@1239,4HA4E@91061,COG0444@1,COG0444@2 NA|NA|NA P Belongs to the ABC transporter superfamily MIPOCGNA_01483 1046629.Ssal_02002 6.2e-61 240.0 Bacilli oppC ko:K15582 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 1TP4R@1239,4H9PZ@91061,COG1173@1,COG1173@2 NA|NA|NA EP ABC-type dipeptide oligopeptide nickel transport systems, permease components MIPOCGNA_01485 1046629.Ssal_02003 8.5e-28 129.0 Bacilli oppB ko:K02033,ko:K15581 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 1TP1S@1239,4HA2S@91061,COG0601@1,COG0601@2 NA|NA|NA P ABC-type dipeptide oligopeptide nickel transport systems, permease components MIPOCGNA_01486 264199.stu0170 8.8e-139 499.6 Bacilli oppA ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 1TNYQ@1239,4HAMK@91061,COG4166@1,COG4166@2 NA|NA|NA E ABC transporter substrate-binding protein MIPOCGNA_01487 435842.HMPREF0848_01501 9.7e-19 99.0 Bacilli oppA ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 1TNYQ@1239,4HAMK@91061,COG4166@1,COG4166@2 NA|NA|NA E ABC transporter substrate-binding protein MIPOCGNA_01488 264199.stu0168 2.2e-273 947.6 Bacilli sufB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 ko:K07033,ko:K09014 ko00000 Bacteria 1TQ21@1239,4HA1Z@91061,COG0719@1,COG0719@2 NA|NA|NA O assembly protein SufB MIPOCGNA_01489 264199.stu0167 4.7e-73 280.4 Bacilli nifU GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0030003,GO:0036455,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0097428,GO:0098771,GO:1901564 ko:K04488 ko00000 Bacteria 1V3H9@1239,4HIJ0@91061,COG0822@1,COG0822@2 NA|NA|NA C SUF system FeS assembly protein, NifU family MIPOCGNA_01490 264199.stu0166 2.3e-237 827.8 Bacilli sufS 2.8.1.7,4.4.1.16 ko:K04487,ko:K11717 ko00450,ko00730,ko01100,ko04122,map00450,map00730,map01100,map04122 R03599,R07460,R11528,R11529 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 Bacteria 1TQ1W@1239,4HA6Z@91061,COG0520@1,COG0520@2 NA|NA|NA E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine MIPOCGNA_01491 322159.STER_0219 6.3e-235 819.7 Bacilli sufD ko:K07033,ko:K09015 ko00000 Bacteria 1TRT0@1239,4HB6W@91061,COG0719@1,COG0719@2 NA|NA|NA O assembly protein SufD MIPOCGNA_01492 264199.stu0164 9.5e-144 516.2 Bacilli sufC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0071840 ko:K09013 ko00000,ko02000 iECH74115_1262.ECH74115_2396,iECIAI1_1343.ECIAI1_1734,iECIAI39_1322.ECIAI39_1376,iECSP_1301.ECSP_2249,iECs_1301.ECs2389,iEcSMS35_1347.EcSMS35_1514,iG2583_1286.G2583_2077,iSFV_1184.SFV_1705,iSFxv_1172.SFxv_1919,iSSON_1240.SSON_1474,iS_1188.S1844,iZ_1308.Z2710 Bacteria 1TQ98@1239,4HAD9@91061,COG0396@1,COG0396@2 NA|NA|NA O ABC-type transport system involved in Fe-S cluster assembly, ATPase component MIPOCGNA_01493 264199.stu0163 3e-183 647.9 Bacilli tagO GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0034645,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0045229,GO:0046872,GO:0046914,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901576 2.7.8.33,2.7.8.35 ko:K02851 R08856 RC00002 ko00000,ko01000,ko01003,ko01005 Bacteria 1TP9V@1239,4H9KT@91061,COG0472@1,COG0472@2 NA|NA|NA M transferase MIPOCGNA_01494 322159.STER_0216 2.3e-136 491.5 Bacilli mecA GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K16511 ko00000 Bacteria 1UZ7D@1239,4HID6@91061,COG4862@1,COG4862@2 NA|NA|NA NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis MIPOCGNA_01495 322159.STER_0215 9.1e-153 546.2 Bacilli uppP GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0031224,GO:0031226,GO:0042221,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050380,GO:0050896,GO:0071944 3.6.1.27 ko:K06153 ko00550,map00550 R05627 RC00002 ko00000,ko00001,ko01000,ko01011 iYL1228.KPN_03461 Bacteria 1TPFA@1239,4HB0M@91061,COG1968@1,COG1968@2 NA|NA|NA V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin MIPOCGNA_01496 322159.STER_0214 1.8e-276 958.0 Bacilli glnP ko:K02029,ko:K02030,ko:K10040,ko:K17073,ko:K17074 ko02010,map02010 M00228,M00236,M00589 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.20 Bacteria 1TPM3@1239,4HAS2@91061,COG0765@1,COG0765@2,COG0834@1,COG0834@2 NA|NA|NA P ABC transporter MIPOCGNA_01497 264199.stu0158 1e-123 449.5 Bacilli glnQ ko:K17074,ko:K17076 ko02010,map02010 M00589 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3.20 Bacteria 1TNYD@1239,4H9WY@91061,COG1126@1,COG1126@2 NA|NA|NA E abc transporter atp-binding protein MIPOCGNA_01500 264199.stu0155 5e-94 350.5 Bacteria Bacteria COG4767@1,COG4767@2 NA|NA|NA V VanZ like family MIPOCGNA_01501 264199.stu0154 9.2e-43 179.1 Bacilli rpsO GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016071,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031123,GO:0031124,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02956 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1VA5C@1239,4HKE9@91061,COG0184@1,COG0184@2 NA|NA|NA J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome MIPOCGNA_01502 322159.STER_0207 1.4e-201 708.8 Bacilli yhjX ko:K03449,ko:K08177 ko00000,ko02000 2.A.1.11,2.A.1.17 Bacteria 1TSM5@1239,4HF98@91061,COG2807@1,COG2807@2 NA|NA|NA P Major Facilitator MIPOCGNA_01503 322159.STER_0206 1.1e-113 416.0 Bacilli fnr5 Bacteria 1V2AH@1239,4HFNC@91061,COG0664@1,COG0664@2 NA|NA|NA K Catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases MIPOCGNA_01504 264199.stu0151 3.3e-112 411.0 Bacilli def GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.31,3.5.1.88 ko:K01450,ko:K01462 ko00270,ko00630,map00270,map00630 R00653 RC00165,RC00323 ko00000,ko00001,ko01000 Bacteria 1V5C6@1239,4HGUI@91061,COG0242@1,COG0242@2 NA|NA|NA J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions MIPOCGNA_01505 322159.STER_0204 1.7e-237 828.2 Bacilli ilvA GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP22@1239,4H9NK@91061,COG1171@1,COG1171@2 NA|NA|NA E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA MIPOCGNA_01506 435842.HMPREF0848_01478 1.7e-39 168.7 Bacilli dex 3.2.1.11 ko:K05988 ko00500,map00500 R11309 ko00000,ko00001,ko01000 GH66 Bacteria 1TS2G@1239,4HF5J@91061,COG5297@1,COG5297@2 NA|NA|NA G Glycosyl hydrolase family 66 MIPOCGNA_01507 1046629.Ssal_02025 2.3e-18 97.4 Bacilli dex 3.2.1.11 ko:K05988 ko00500,map00500 R11309 ko00000,ko00001,ko01000 GH66 Bacteria 1TS2G@1239,4HF5J@91061,COG5297@1,COG5297@2 NA|NA|NA G Glycosyl hydrolase family 66 MIPOCGNA_01508 1046629.Ssal_02025 3e-28 131.0 Bacilli dex 3.2.1.11 ko:K05988 ko00500,map00500 R11309 ko00000,ko00001,ko01000 GH66 Bacteria 1TS2G@1239,4HF5J@91061,COG5297@1,COG5297@2 NA|NA|NA G Glycosyl hydrolase family 66 MIPOCGNA_01509 1046629.Ssal_02025 2e-08 64.3 Bacilli dex 3.2.1.11 ko:K05988 ko00500,map00500 R11309 ko00000,ko00001,ko01000 GH66 Bacteria 1TS2G@1239,4HF5J@91061,COG5297@1,COG5297@2 NA|NA|NA G Glycosyl hydrolase family 66 MIPOCGNA_01510 264199.stu0146 3.3e-74 284.3 Bacilli dtd GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106026,GO:0106074,GO:0140098,GO:0140101,GO:1901360 ko:K07560 ko00000,ko01000,ko03016 Bacteria 1V6GH@1239,4HINN@91061,COG1490@1,COG1490@2 NA|NA|NA J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality MIPOCGNA_01511 322159.STER_0200 0.0 1432.5 Bacilli relA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009605,GO:0009987,GO:0009991,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5 ko:K00951 ko00230,map00230 R00429 RC00002,RC00078 ko00000,ko00001,ko01000 iHN637.CLJU_RS16615,iYO844.BSU27600 Bacteria 1TNYZ@1239,4HBX7@91061,COG0317@1,COG0317@2 NA|NA|NA KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance MIPOCGNA_01512 264199.stu0144 5.3e-83 313.5 Bacilli nrdI ko:K03647 ko00000 Bacteria 1V71V@1239,4HIW7@91061,COG1780@1,COG1780@2 NA|NA|NA F Belongs to the NrdI family MIPOCGNA_01513 322159.STER_0198 1e-241 842.4 Bacilli cpdB GO:0003674,GO:0003824,GO:0004112,GO:0005575,GO:0005623,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0008252,GO:0008254,GO:0008663,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0030288,GO:0030313,GO:0031975,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0042597,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.1.3.6,3.1.4.16 ko:K01119 ko00230,ko00240,map00230,map00240 R01562,R01877,R02148,R02370,R03537,R03538,R03929,R05135 RC00078,RC00296 ko00000,ko00001,ko01000 iEC55989_1330.EC55989_4773,iECH74115_1262.ECH74115_5730,iECNA114_1301.ECNA114_4436,iECSP_1301.ECSP_5315,iECW_1372.ECW_m4577,iECs_1301.ECs5191,iEKO11_1354.EKO11_4095,iEcE24377_1341.EcE24377A_4783,iG2583_1286.G2583_5043,iWFL_1372.ECW_m4577,iZ_1308.Z5824 Bacteria 1TPV2@1239,4HB9S@91061,COG0737@1,COG0737@2 NA|NA|NA F Belongs to the 5'-nucleotidase family MIPOCGNA_01514 264199.stu0141 2.1e-21 108.2 Bacilli cpdB GO:0003674,GO:0003824,GO:0004112,GO:0005575,GO:0005623,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0008252,GO:0008254,GO:0008663,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0030288,GO:0030313,GO:0031975,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0042597,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.1.3.6,3.1.4.16 ko:K01119 ko00230,ko00240,map00230,map00240 R01562,R01877,R02148,R02370,R03537,R03538,R03929,R05135 RC00078,RC00296 ko00000,ko00001,ko01000 iEC55989_1330.EC55989_4773,iECH74115_1262.ECH74115_5730,iECNA114_1301.ECNA114_4436,iECSP_1301.ECSP_5315,iECW_1372.ECW_m4577,iECs_1301.ECs5191,iEKO11_1354.EKO11_4095,iEcE24377_1341.EcE24377A_4783,iG2583_1286.G2583_5043,iWFL_1372.ECW_m4577,iZ_1308.Z5824 Bacteria 1TPV2@1239,4HB9S@91061,COG0737@1,COG0737@2 NA|NA|NA F Belongs to the 5'-nucleotidase family MIPOCGNA_01515 1046629.Ssal_02030 8.6e-45 186.0 Bacilli cpdB GO:0003674,GO:0003824,GO:0004112,GO:0005575,GO:0005623,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0008252,GO:0008254,GO:0008663,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0030288,GO:0030313,GO:0031975,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0042597,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.1.3.6,3.1.4.16 ko:K01119 ko00230,ko00240,map00230,map00240 R01562,R01877,R02148,R02370,R03537,R03538,R03929,R05135 RC00078,RC00296 ko00000,ko00001,ko01000 iEC55989_1330.EC55989_4773,iECH74115_1262.ECH74115_5730,iECNA114_1301.ECNA114_4436,iECSP_1301.ECSP_5315,iECW_1372.ECW_m4577,iECs_1301.ECs5191,iEKO11_1354.EKO11_4095,iEcE24377_1341.EcE24377A_4783,iG2583_1286.G2583_5043,iWFL_1372.ECW_m4577,iZ_1308.Z5824 Bacteria 1TPV2@1239,4HB9S@91061,COG0737@1,COG0737@2 NA|NA|NA F Belongs to the 5'-nucleotidase family MIPOCGNA_01516 322159.STER_0198 1.5e-35 156.0 Bacilli cpdB GO:0003674,GO:0003824,GO:0004112,GO:0005575,GO:0005623,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0008252,GO:0008254,GO:0008663,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0030288,GO:0030313,GO:0031975,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0042597,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.1.3.6,3.1.4.16 ko:K01119 ko00230,ko00240,map00230,map00240 R01562,R01877,R02148,R02370,R03537,R03538,R03929,R05135 RC00078,RC00296 ko00000,ko00001,ko01000 iEC55989_1330.EC55989_4773,iECH74115_1262.ECH74115_5730,iECNA114_1301.ECNA114_4436,iECSP_1301.ECSP_5315,iECW_1372.ECW_m4577,iECs_1301.ECs5191,iEKO11_1354.EKO11_4095,iEcE24377_1341.EcE24377A_4783,iG2583_1286.G2583_5043,iWFL_1372.ECW_m4577,iZ_1308.Z5824 Bacteria 1TPV2@1239,4HB9S@91061,COG0737@1,COG0737@2 NA|NA|NA F Belongs to the 5'-nucleotidase family MIPOCGNA_01517 322159.STER_0197 3.7e-134 484.2 Bacilli rsmE GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070042,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.193 ko:K09761 ko00000,ko01000,ko03009 Bacteria 1V1CT@1239,4HH8P@91061,COG1385@1,COG1385@2 NA|NA|NA J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit MIPOCGNA_01518 264199.stu0137 1.3e-176 625.5 Bacilli prmA ko:K02687 ko00000,ko01000,ko03009 Bacteria 1TPKI@1239,4HAMF@91061,COG2264@1,COG2264@2 NA|NA|NA J Ribosomal protein L11 methyltransferase MIPOCGNA_01519 322159.STER_0195 3.1e-80 304.3 Bacilli mutT3 3.6.1.13,3.6.1.55 ko:K01515,ko:K03574 ko00230,map00230 R01054 RC00002 ko00000,ko00001,ko01000,ko03400 Bacteria 1V8D5@1239,4HJKW@91061,COG0494@1,COG0494@2 NA|NA|NA L NUDIX domain MIPOCGNA_01520 264199.stu0135 4.2e-83 313.9 Bacilli XK27_03960 Bacteria 1VFZQ@1239,2E0MY@1,32W75@2,4HKWR@91061 NA|NA|NA S Protein of unknown function (DUF3013) MIPOCGNA_01521 264199.stu0134 7.6e-310 1068.9 Bacilli pyrG GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS01075,iNJ661.Rv1699 Bacteria 1TP34@1239,4H9X6@91061,COG0504@1,COG0504@2 NA|NA|NA F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates MIPOCGNA_01522 322159.STER_0192 4.8e-73 280.8 Bacilli rpoE GO:0003674,GO:0003824,GO:0003899,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 ko:K03048 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko03021,ko03400 Bacteria 1V6WX@1239,4HIUK@91061,COG3343@1,COG3343@2 NA|NA|NA K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling MIPOCGNA_01523 322159.STER_0191 6.4e-219 766.5 Bacilli tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 ko:K03545 ko00000 Bacteria 1TQQ8@1239,4H9Q8@91061,COG0544@1,COG0544@2 NA|NA|NA D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase MIPOCGNA_01524 264199.stu0131 1.6e-146 525.4 Bacilli ykuT GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0006810,GO:0006950,GO:0006970,GO:0008150,GO:0008381,GO:0009628,GO:0009987,GO:0015267,GO:0022803,GO:0022836,GO:0022857,GO:0033554,GO:0042802,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071214,GO:0071470,GO:0104004 ko:K22044 ko00000,ko02000 1.A.23.3 Bacteria 1TR9Z@1239,4HCB8@91061,COG0668@1,COG0668@2 NA|NA|NA M mechanosensitive ion channel MIPOCGNA_01525 1046629.Ssal_02044 1.6e-77 295.4 Bacteria sigH ko:K03088,ko:K03091,ko:K12296 ko02020,ko02024,map02020,map02024 ko00000,ko00001,ko03000,ko03021 Bacteria COG1595@1,COG1595@2 NA|NA|NA K DNA-templated transcription, initiation MIPOCGNA_01526 264199.stu0838 8e-42 176.0 Bacilli ko:K03704 ko00000,ko03000 Bacteria 1VEE0@1239,4HNJC@91061,COG1278@1,COG1278@2 NA|NA|NA K Cold-Shock Protein MIPOCGNA_01527 322159.STER_0879 9.3e-32 142.1 Bacilli cspD GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006275,GO:0006355,GO:0006950,GO:0008150,GO:0008156,GO:0009266,GO:0009409,GO:0009605,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0009991,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031667,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2000113,GO:2001141 ko:K03704 ko00000,ko03000 Bacteria 1W15H@1239,4HXYN@91061,COG1278@1,COG1278@2 NA|NA|NA K Cold shock protein domain MIPOCGNA_01528 416870.llmg_1254 2.4e-27 127.5 Lactococcus Bacteria 1U9S4@1239,1YCN6@1357,29RCS@1,30CEY@2,4ID5R@91061 NA|NA|NA MIPOCGNA_01530 1069533.Sinf_0805 7.1e-28 129.4 Bacteria ko:K07483 ko00000 Bacteria COG2963@1,COG2963@2 NA|NA|NA L transposase activity MIPOCGNA_01531 1116231.SMA_0302 9.9e-64 249.2 Bacilli tnp ko:K07498 ko00000 Bacteria 1UTIC@1239,4HCF1@91061,COG3316@1,COG3316@2 NA|NA|NA L DDE domain MIPOCGNA_01532 1046629.Ssal_00974 2.6e-44 184.5 Bacilli pepD ko:K08659 ko00000,ko01000,ko01002 Bacteria 1TQ0F@1239,4HC3G@91061,COG4690@1,COG4690@2 NA|NA|NA E Dipeptidase MIPOCGNA_01533 264199.stu0835 5.8e-77 293.5 Bacilli pepD ko:K08659 ko00000,ko01000,ko01002 Bacteria 1TQ0F@1239,4HC3G@91061,COG4690@1,COG4690@2 NA|NA|NA E Dipeptidase MIPOCGNA_01534 904306.HMPREF9192_1264 7.2e-25 119.4 Bacilli pepD ko:K08659 ko00000,ko01000,ko01002 Bacteria 1TQ0F@1239,4HC3G@91061,COG4690@1,COG4690@2 NA|NA|NA E Dipeptidase MIPOCGNA_01535 264199.stu0833 1.9e-161 575.1 Bacilli whiA GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0043937,GO:0044464,GO:0050789,GO:0050793,GO:0065007,GO:0071944 ko:K09762 ko00000 Bacteria 1TP2X@1239,4HB4H@91061,COG1481@1,COG1481@2 NA|NA|NA K May be required for sporulation MIPOCGNA_01536 322159.STER_0876 3.6e-182 644.0 Bacilli ybhK Bacteria 1TPNV@1239,4HA0Z@91061,COG0391@1,COG0391@2 NA|NA|NA S Required for morphogenesis under gluconeogenic growth conditions MIPOCGNA_01537 264199.stu0831 4.5e-163 580.5 Bacilli rapZ GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363 ko:K06958 ko00000,ko03019 Bacteria 1TPS4@1239,4H9KM@91061,COG1660@1,COG1660@2 NA|NA|NA S Displays ATPase and GTPase activities MIPOCGNA_01538 322159.STER_0874 8.5e-134 483.0 Bacilli yejC Bacteria 1V46X@1239,4HI49@91061,COG4420@1,COG4420@2 NA|NA|NA S cyclic nucleotide-binding protein MIPOCGNA_01539 1046629.Ssal_00969 3.6e-17 93.6 Bacteria Bacteria COG1196@1,COG1196@2 NA|NA|NA D nuclear chromosome segregation MIPOCGNA_01540 904306.HMPREF9192_0984 8.3e-160 569.7 Bacilli 4.1.3.39 ko:K01666 ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220 M00545,M00569 R00750 RC00307,RC00371 br01602,ko00000,ko00001,ko00002,ko01000 Bacteria 1TS0A@1239,4HAXZ@91061,COG0119@1,COG0119@2 NA|NA|NA E Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds MIPOCGNA_01542 904306.HMPREF9192_0987 4e-209 733.8 Bacilli dlpA 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1TPEM@1239,4HA76@91061,COG0473@1,COG0473@2 NA|NA|NA CE Tartrate dehydrogenase MIPOCGNA_01543 904306.HMPREF9192_0988 7.7e-123 446.4 Bacilli dlpA Bacteria 1V1ME@1239,4HGQE@91061,COG0684@1,COG0684@2 NA|NA|NA H Methyltransferase MIPOCGNA_01544 904306.HMPREF9192_0989 6.8e-153 546.6 Firmicutes Bacteria 1UKB6@1239,COG1735@1,COG1735@2 NA|NA|NA S metal-dependent hydrolase with the TIM-barrel fold MIPOCGNA_01545 575606.HMPREF0525_01168 1.2e-71 276.6 Lactobacillaceae 2.7.7.12 ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 M00362,M00554,M00632 R00955 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 1TSNU@1239,3F3JH@33958,4H9TY@91061,COG1085@1,COG1085@2 NA|NA|NA C Domain of unknown function (DUF4931) MIPOCGNA_01546 904306.HMPREF9192_0991 6.3e-160 570.1 Bacilli yrdR Bacteria 1UZGC@1239,4HDET@91061,COG0697@1,COG0697@2 NA|NA|NA EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily MIPOCGNA_01547 1423734.JCM14202_2269 4.7e-16 91.7 Bacilli Bacteria 1UZT5@1239,4IPKX@91061,COG0640@1,COG0640@2 NA|NA|NA K helix_turn_helix, Arsenical Resistance Operon Repressor MIPOCGNA_01548 536227.CcarbDRAFT_1827 2.4e-13 81.6 Clostridiaceae arsR Bacteria 1V5AM@1239,24JP3@186801,36PN5@31979,COG0640@1,COG0640@2 NA|NA|NA K helix_turn_helix, Arsenical Resistance Operon Repressor MIPOCGNA_01549 1008453.HMPREF9957_1401 5.1e-21 107.1 Streptococcus mitis ko:K07497 ko00000 Bacteria 1TRR6@1239,2TP00@28037,4HAJS@91061,COG2801@1,COG2801@2 NA|NA|NA L overlaps another CDS with the same product name MIPOCGNA_01550 264199.stu1395 7.6e-230 802.7 Bacilli sbcD ko:K03547 ko00000,ko03400 Bacteria 1TQY6@1239,4HAKB@91061,COG0420@1,COG0420@2 NA|NA|NA L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity MIPOCGNA_01551 264199.stu1394 0.0 1419.1 Bacilli sbcC ko:K03546 ko00000,ko03400 Bacteria 1TPCS@1239,4H9Q3@91061,COG0419@1,COG0419@2 NA|NA|NA L ATPase involved in DNA repair MIPOCGNA_01552 706433.HMPREF9430_01341 1e-31 143.3 Firmicutes Bacteria 1V146@1239,28ITE@1,2Z8SB@2 NA|NA|NA MIPOCGNA_01553 1403946.Q615_SPAC00123G0004 9e-44 182.6 Bacilli ko:K07483 ko00000 Bacteria 1V9ZX@1239,4HKN9@91061,COG2963@1,COG2963@2 NA|NA|NA L COG2963 Transposase and inactivated derivatives MIPOCGNA_01554 1403946.Q615_SPAC00123G0003 2.2e-61 241.5 Bacilli Bacteria 1TPEH@1239,4HCHG@91061,COG2801@1,COG2801@2 NA|NA|NA L Transposase and inactivated derivatives MIPOCGNA_01555 1123299.AUKZ01000032_gene1329 5.1e-40 169.9 Bacteria Bacteria COG2801@1,COG2801@2 NA|NA|NA L transposition MIPOCGNA_01556 862970.SAIN_0151 2.2e-17 95.9 Streptococcus anginosus group Bacteria 1TVY9@1239,29H5Y@1,3043H@2,42EEJ@671232,4I4K4@91061 NA|NA|NA MIPOCGNA_01557 264199.stu1236 6.9e-217 759.6 Bacilli hemN GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 Bacteria 1TPES@1239,4HA60@91061,COG0635@1,COG0635@2 NA|NA|NA H Involved in the biosynthesis of porphyrin-containing compound MIPOCGNA_01558 264199.stu1235 4.8e-142 510.4 Bacilli fat 3.1.2.21 ko:K01071 ko00061,ko01100,map00061,map01100 R04014,R08157,R08158 RC00014,RC00039 ko00000,ko00001,ko01000,ko01004 Bacteria 1V3RB@1239,4HHJ4@91061,COG3884@1,COG3884@2 NA|NA|NA I Acyl-ACP thioesterase MIPOCGNA_01559 322159.STER_1214 5.9e-143 513.5 Bacilli nagD 2.7.1.25,3.1.3.41 ko:K00860,ko:K01101 ko00230,ko00627,ko00920,ko01100,ko01120,map00230,map00627,map00920,map01100,map01120 M00176 R00509,R03024,R04928 RC00002,RC00078,RC00151 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQGM@1239,4HA3R@91061,COG0647@1,COG0647@2 NA|NA|NA G Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro MIPOCGNA_01560 322159.STER_1213 3.4e-120 437.6 Bacilli ylfI Bacteria 1VGZ1@1239,4HNTM@91061,COG4478@1,COG4478@2 NA|NA|NA S tigr01906 MIPOCGNA_01561 322159.STER_1212 5.8e-140 503.4 Bacilli hisK 3.1.3.15 ko:K04486 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013 RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 1V77D@1239,4HGYX@91061,COG1387@1,COG1387@2 NA|NA|NA E Histidinol phosphatase and related hydrolases of the PHP family MIPOCGNA_01562 1046629.Ssal_01327 7.9e-10 69.3 Bacilli XK27_08080 3.1.1.53 ko:K05970 ko00000,ko01000 Bacteria 1TR6Z@1239,4HGB0@91061,COG4632@1,COG4632@2 NA|NA|NA G Exopolysaccharide biosynthesis protein MIPOCGNA_01563 322159.STER_1210 8.4e-88 329.7 Bacilli XK27_08080 3.1.1.53 ko:K05970 ko00000,ko01000 Bacteria 1TR6Z@1239,4HGB0@91061,COG4632@1,COG4632@2 NA|NA|NA G Exopolysaccharide biosynthesis protein MIPOCGNA_01564 435842.HMPREF0848_00449 2e-31 141.4 Firmicutes XK27_08085 Bacteria 1VM50@1239,2EJUK@1,33DJ8@2 NA|NA|NA MIPOCGNA_01565 904306.HMPREF9192_0691 9.5e-140 503.1 Bacilli blpT Bacteria 1W6SH@1239,2DWQH@1,341F6@2,4HX74@91061 NA|NA|NA MIPOCGNA_01566 322159.STER_1636 3e-47 194.1 Bacteria spiA ko:K18831 ko00000,ko02048,ko03000 Bacteria COG1476@1,COG1476@2 NA|NA|NA K sequence-specific DNA binding MIPOCGNA_01569 322159.STER_1633 0.0 1513.8 Bacilli pepX 3.4.14.11 ko:K01281 ko00000,ko01000,ko01002 Bacteria 1TT78@1239,4HBA0@91061,COG2936@1,COG2936@2 NA|NA|NA E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline MIPOCGNA_01570 264199.stu1671 2.3e-164 584.7 Bacilli gla ko:K02440 ko00000,ko02000 1.A.8.1,1.A.8.2 Bacteria 1TP4T@1239,4HE39@91061,COG0580@1,COG0580@2 NA|NA|NA U Belongs to the MIP aquaporin (TC 1.A.8) family MIPOCGNA_01571 322159.STER_1913 2.7e-249 867.5 Bacilli purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQ4C@1239,4H9YT@91061,COG0104@1,COG0104@2 NA|NA|NA F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP MIPOCGNA_01572 1046629.Ssal_00076 1.1e-89 335.9 Bacilli adk 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1V7AW@1239,4HH8A@91061,COG0563@1,COG0563@2 NA|NA|NA F topology modulation protein MIPOCGNA_01573 1116231.SMA_1917 2.2e-186 658.3 Bacteria yxaM Bacteria COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily MIPOCGNA_01574 322159.STER_1916 1.9e-197 694.9 Bacteria 2.7.7.73,2.7.7.80 ko:K03148,ko:K21029 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07459 RC00043 ko00000,ko00001,ko01000 Bacteria COG0476@1,COG0476@2 NA|NA|NA H Involved in molybdopterin and thiamine biosynthesis, family 2 MIPOCGNA_01577 525379.HMPREF0819_1359 3.3e-31 140.6 Bacilli Bacteria 1VK2R@1239,2ED8H@1,33752@2,4HQ99@91061 NA|NA|NA MIPOCGNA_01578 322159.STER_1960 4.5e-39 166.8 Bacilli Bacteria 1VK2R@1239,2ED8H@1,33752@2,4HQ99@91061 NA|NA|NA MIPOCGNA_01579 1116231.SMA_0314 9.7e-22 108.6 Bacteria Bacteria COG5547@1,COG5547@2 NA|NA|NA S Small integral membrane protein MIPOCGNA_01580 264199.stu1986 9e-77 293.1 Bacteria Bacteria COG1302@1,COG1302@2 NA|NA|NA M Protein conserved in bacteria MIPOCGNA_01581 525379.HMPREF0819_1362 1e-09 68.9 Bacteria Bacteria COG3237@1,COG3237@2 NA|NA|NA K CsbD-like MIPOCGNA_01582 888821.HMPREF9394_0461 6.7e-125 454.1 Bacilli gltT ko:K03309,ko:K11102 ko00000,ko02000 2.A.23,2.A.23.1.1,2.A.23.1.2 Bacteria 1TPME@1239,4H9T7@91061,COG1301@1,COG1301@2 NA|NA|NA C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family MIPOCGNA_01583 1005705.HMPREF9967_1422 1.4e-135 489.2 Streptococcus infantis Bacteria 1TSHN@1239,43FXH@68892,4HBFG@91061,COG0189@1,COG0189@2 NA|NA|NA HJ the current gene model (or a revised gene model) may contain a frame shift MIPOCGNA_01584 1046629.Ssal_00038 1.1e-107 396.0 Bacilli nudL GO:0003674,GO:0003824,GO:0016787,GO:0016817,GO:0016818 Bacteria 1V6SF@1239,4HG46@91061,COG0494@1,COG0494@2 NA|NA|NA L hydrolase MIPOCGNA_01585 322159.STER_1963 1.1e-11 75.5 Bacteria Bacteria COG3237@1,COG3237@2 NA|NA|NA K CsbD-like MIPOCGNA_01586 264199.stu1986 6.5e-83 313.5 Bacteria Bacteria COG1302@1,COG1302@2 NA|NA|NA M Protein conserved in bacteria MIPOCGNA_01587 264199.stu1984 1.8e-23 114.4 Bacteria Bacteria COG5547@1,COG5547@2 NA|NA|NA S Small integral membrane protein MIPOCGNA_01588 322159.STER_1960 1.7e-99 368.6 Bacilli Bacteria 1VK2R@1239,2ED8H@1,33752@2,4HQ99@91061 NA|NA|NA MIPOCGNA_01589 46256.BBIK01000021_gene1814 0.0 1138.3 Leuconostocaceae copB 3.6.3.4 ko:K01533 R00086 RC00002 ko00000,ko01000 3.A.3.5 Bacteria 1TP5S@1239,4AX7X@81850,4HAI0@91061,COG2217@1,COG2217@2 NA|NA|NA P COG2217 Cation transport ATPase MIPOCGNA_01590 264199.stu1455 2.9e-179 634.4 Bacilli pta 2.3.1.8,3.6.3.21 ko:K00625,ko:K02028,ko:K13788 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00236,M00357,M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3 iSB619.SA_RS03155 Bacteria 1TPQ0@1239,4H9VH@91061,COG0280@1,COG0280@2 NA|NA|NA C phosphate acetyltransferase MIPOCGNA_01591 264199.stu1456 2.8e-173 614.4 Bacilli rluD GO:0000027,GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022607,GO:0022613,GO:0022618,GO:0031118,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 5.4.99.23,5.4.99.28,5.4.99.29 ko:K06177,ko:K06180 ko00000,ko01000,ko03009,ko03016 iE2348C_1286.E2348C_2868,iECED1_1282.ECED1_3035,iECSF_1327.ECSF_2432 Bacteria 1TS1T@1239,4HBRY@91061,COG0564@1,COG0564@2 NA|NA|NA J Responsible for synthesis of pseudouridine from uracil MIPOCGNA_01592 264199.stu1457 3.7e-151 540.8 Bacilli nadK GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 R00104 RC00002,RC00078 ko00000,ko00001,ko01000 iEcSMS35_1347.EcSMS35_2767,iHN637.CLJU_RS05480,iLJ478.TM1733,iSB619.SA_RS04895 Bacteria 1TRB3@1239,4HB08@91061,COG0061@1,COG0061@2 NA|NA|NA H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP MIPOCGNA_01593 264199.stu1459 1.4e-119 435.6 Bacilli yjbM 2.7.6.5 ko:K07816 ko00230,map00230 R00429 RC00002,RC00078 ko00000,ko00001,ko01000 Bacteria 1TQ2F@1239,4HA3Q@91061,COG2357@1,COG2357@2 NA|NA|NA S Gtp pyrophosphokinase MIPOCGNA_01594 264199.stu1458 1.5e-103 382.1 Bacilli yjbK Bacteria 1VA56@1239,4HMNE@91061,COG4116@1,COG4116@2 NA|NA|NA S Adenylate cyclase MIPOCGNA_01595 322159.STER_1425 1.2e-177 629.0 Bacilli prs 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2848 Bacteria 1TQ4I@1239,4HDRN@91061,COG0462@1,COG0462@2 NA|NA|NA F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) MIPOCGNA_01596 264199.stu1461 3.2e-206 724.2 Bacilli iscS 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 Bacteria 1TP21@1239,4HA6H@91061,COG1104@1,COG1104@2 NA|NA|NA E Cysteine desulfurase MIPOCGNA_01597 322159.STER_1427 1.2e-58 232.3 Bacilli XK27_04120 Bacteria 1VDSF@1239,2DHWG@1,32U9W@2,4HP9N@91061 NA|NA|NA S Putative amino acid metabolism MIPOCGNA_01598 264199.stu1463 6.3e-117 426.8 Bacilli rex ko:K01926 ko00000,ko03000 Bacteria 1TSMR@1239,4HB7Q@91061,COG2344@1,COG2344@2 NA|NA|NA K Modulates transcription in response to changes in cellular NADH NAD( ) redox state MIPOCGNA_01599 904306.HMPREF9192_0931 2.7e-123 448.0 Bacilli puuD ko:K07010 ko00000,ko01002 Bacteria 1V1KC@1239,4HI59@91061,COG2071@1,COG2071@2 NA|NA|NA T peptidase C26 MIPOCGNA_01600 322159.STER_1430 3.9e-114 417.5 Bacilli radC ko:K03630 ko00000 Bacteria 1TQ3K@1239,4HB1W@91061,COG2003@1,COG2003@2 NA|NA|NA E Belongs to the UPF0758 family MIPOCGNA_01601 264199.stu1467 0.0 1217.6 Bacilli rgpF ko:K07272 ko00000,ko01000,ko01003,ko01005 Bacteria 1V95X@1239,4HIXP@91061,COG3754@1,COG3754@2 NA|NA|NA M Rhamnan synthesis protein F MIPOCGNA_01602 264199.stu1468 3.1e-195 687.6 Bacilli rgpEc ko:K12998 ko00000,ko01000,ko01003,ko01005 GT2 Bacteria 1TSUF@1239,4HF68@91061,COG0463@1,COG0463@2 NA|NA|NA M COG0463 Glycosyltransferases involved in cell wall biogenesis MIPOCGNA_01603 264199.stu1469 8.7e-226 789.3 Bacilli rgpD 3.6.3.38 ko:K01990,ko:K09689,ko:K09691 ko02010,map02010 M00249,M00250,M00254 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.101,3.A.1.103 Bacteria 1TQKK@1239,4HC6N@91061,COG1134@1,COG1134@2 NA|NA|NA P Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system MIPOCGNA_01604 264199.stu1470 1.4e-142 512.3 Bacilli rgpC ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1V1J2@1239,4HI7C@91061,COG1682@1,COG1682@2 NA|NA|NA GM Transport permease protein MIPOCGNA_01605 264199.stu1471 6.3e-179 633.3 Bacilli rgpB ko:K12997 ko00000,ko01000,ko01003,ko01005 GT2 Bacteria 1V7IQ@1239,4HK7R@91061,COG0463@1,COG0463@2 NA|NA|NA M Glycosyltransferase, group 2 family protein MIPOCGNA_01606 264199.stu1472 3.5e-224 783.9 Bacilli rgpA ko:K12996 ko00000,ko01000,ko01003,ko01005 GT4 Bacteria 1V7K7@1239,4HA9A@91061,COG0438@1,COG0438@2 NA|NA|NA M Domain of unknown function (DUF1972) MIPOCGNA_01607 889201.HMPREF9422_0750 6.4e-141 507.7 Bacilli Bacteria 1TU1A@1239,4HU08@91061,COG4713@1,COG4713@2 NA|NA|NA S Predicted membrane protein (DUF2142) MIPOCGNA_01608 264199.stu1473 2.6e-183 647.9 Bacteria tagF 2.7.8.12 ko:K09809,ko:K19046 ko00000,ko01000,ko02048 Bacteria COG0463@1,COG0463@2 NA|NA|NA M Glycosyl transferase, family 2 MIPOCGNA_01609 264199.stu1480 5.8e-220 770.0 Bacilli amrA Bacteria 1TTBW@1239,4IR8C@91061,COG2244@1,COG2244@2 NA|NA|NA S polysaccharide biosynthetic process MIPOCGNA_01610 264199.stu1481 5.3e-48 196.8 Bacilli XK27_09090 ko:K09153 ko00000 Bacteria 1VFCF@1239,4HM3R@91061,COG2456@1,COG2456@2 NA|NA|NA S Uncharacterized conserved protein (DUF2304) MIPOCGNA_01611 264199.stu1482 2.2e-125 454.9 Bacilli ycbB Bacteria 1TS11@1239,4HVX1@91061,COG1216@1,COG1216@2 NA|NA|NA S Glycosyl transferase family 2 MIPOCGNA_01612 264199.stu1483 4e-161 573.9 Bacilli rfbD 1.1.1.133,5.1.3.13 ko:K00067,ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777,R06514 RC00182,RC01531 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP71@1239,4HBXF@91061,COG1091@1,COG1091@2 NA|NA|NA M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose MIPOCGNA_01613 264199.stu1484 1.9e-245 854.7 Firmicutes Bacteria 1VPDR@1239,2DSN8@1,33GRU@2 NA|NA|NA MIPOCGNA_01614 322159.STER_1446 1.8e-170 605.1 Bacilli yfdH ko:K12999,ko:K20534 ko00000,ko01000,ko01003,ko01005,ko02000 4.D.2.1.9 GT2 Bacteria 1TPR3@1239,4HC2Z@91061,COG0463@1,COG0463@2 NA|NA|NA M COG0463, glycosyltransferases involved in cell wall biogenesis MIPOCGNA_01615 264199.stu1487 3.4e-55 220.7 Bacilli yitW ko:K02612 ko00360,ko01120,map00360,map01120 R09838 RC02690 ko00000,ko00001 Bacteria 1V9YV@1239,4HKC6@91061,COG2151@1,COG2151@2 NA|NA|NA K metal-sulfur cluster biosynthetic enzyme MIPOCGNA_01616 322159.STER_1448 1.1e-201 709.1 Bacilli sigA GO:0000988,GO:0000990,GO:0001098,GO:0001101,GO:0001108,GO:0001666,GO:0002791,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009405,GO:0009408,GO:0009410,GO:0009415,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010035,GO:0010468,GO:0010556,GO:0010557,GO:0010565,GO:0010604,GO:0010628,GO:0016020,GO:0016987,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0019899,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032879,GO:0032880,GO:0036293,GO:0040007,GO:0042221,GO:0043175,GO:0043254,GO:0044087,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050708,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051049,GO:0051128,GO:0051171,GO:0051173,GO:0051223,GO:0051252,GO:0051254,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0070063,GO:0070201,GO:0070482,GO:0071944,GO:0080090,GO:0090087,GO:0097159,GO:0140110,GO:1901363,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:1903530,GO:2000112,GO:2000142,GO:2001141 ko:K03086,ko:K03087 ko02026,ko05111,map02026,map05111 ko00000,ko00001,ko03021 Bacteria 1TPD6@1239,4HB1H@91061,COG0568@1,COG0568@2 NA|NA|NA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth MIPOCGNA_01617 264199.stu1489 0.0 1161.7 Bacilli dnaG ko:K02316 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Bacteria 1TQ0X@1239,4HAG2@91061,COG0358@1,COG0358@2 NA|NA|NA L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication MIPOCGNA_01618 873449.STRCR_1157 4.3e-46 190.7 Bacilli mscL GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 ko:K03282 ko00000,ko02000 1.A.22.1 Bacteria 1VA14@1239,4HKIA@91061,COG1970@1,COG1970@2 NA|NA|NA M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell MIPOCGNA_01619 1046629.Ssal_00586 1.2e-19 101.7 Bacilli rpsU GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02970 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1VEHU@1239,4HNPV@91061,COG0828@1,COG0828@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bS21 family MIPOCGNA_01620 322159.STER_1452 4.2e-136 490.7 Bacilli gltS ko:K02030,ko:K17073,ko:K17074 ko02010,map02010 M00236,M00589 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.20 Bacteria 1TT16@1239,4HD16@91061,COG0834@1,COG0834@2 NA|NA|NA ET Belongs to the bacterial solute-binding protein 3 family MIPOCGNA_01621 264199.stu1493 7.5e-200 703.0 Bacilli arcT 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 Bacteria 1TQPD@1239,4HE7P@91061,COG0436@1,COG0436@2 NA|NA|NA E Aminotransferase MIPOCGNA_01622 322159.STER_1454 4.7e-135 487.3 Bacilli ko:K02030,ko:K17073,ko:K17074 ko02010,map02010 M00236,M00589 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.20 Bacteria 1TT16@1239,4HJ2R@91061,COG0834@1,COG0834@2 NA|NA|NA ET ABC transporter MIPOCGNA_01623 264199.stu1495 1.7e-140 505.4 Firmicutes ko:K02030,ko:K17073,ko:K17074 ko02010,map02010 M00236,M00589 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.20 Bacteria 1TT16@1239,COG0834@1,COG0834@2 NA|NA|NA ET Belongs to the bacterial solute-binding protein 3 family MIPOCGNA_01624 322159.STER_1456 2.9e-84 317.8 Firmicutes mutT 3.6.1.55 ko:K03574 ko00000,ko01000,ko03400 Bacteria 1V3MM@1239,COG1051@1,COG1051@2 NA|NA|NA F Nudix family MIPOCGNA_01625 322159.STER_1457 0.0 1291.6 Bacilli uvrB ko:K03702,ko:K08999 ko03420,map03420 ko00000,ko00001,ko03400 Bacteria 1TPKB@1239,4HB81@91061,COG0556@1,COG0556@2 NA|NA|NA L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage MIPOCGNA_01627 904306.HMPREF9192_0897 4.3e-82 310.8 Bacilli ko:K07052 ko00000 Bacteria 1VA8S@1239,4IQWI@91061,COG1266@1,COG1266@2 NA|NA|NA S CAAX amino terminal protease family protein MIPOCGNA_01628 904306.HMPREF9192_0897 2.4e-33 147.9 Bacilli ko:K07052 ko00000 Bacteria 1VA8S@1239,4IQWI@91061,COG1266@1,COG1266@2 NA|NA|NA S CAAX amino terminal protease family protein MIPOCGNA_01629 322159.STER_1461 0.0 1363.2 Bacilli glnP ko:K02029,ko:K02030,ko:K10040,ko:K17073,ko:K17074 ko02010,map02010 M00228,M00236,M00589 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.20 Bacteria 1TQUG@1239,4HAJ5@91061,COG0765@1,COG0765@2,COG0834@1,COG0834@2 NA|NA|NA P ABC-type amino acid transport signal transduction systems periplasmic component domain MIPOCGNA_01630 322159.STER_1462 6e-137 493.4 Bacilli glnQ 3.6.3.21 ko:K02028,ko:K10038 ko02010,map02010 M00227,M00236 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.2 Bacteria 1TNYD@1239,4H9WY@91061,COG1126@1,COG1126@2 NA|NA|NA E abc transporter atp-binding protein MIPOCGNA_01631 1214217.ALNF01000018_gene931 1.1e-16 92.0 Streptococcus suis XK27_00735 Bacteria 1U94Q@1239,1WTRS@1307,29R2M@1,30C3R@2,4IJ5T@91061 NA|NA|NA MIPOCGNA_01632 264199.stu1504 1.4e-248 865.1 Bacilli obg GO:0000003,GO:0000160,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019954,GO:0023052,GO:0030436,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035556,GO:0035639,GO:0036094,GO:0043021,GO:0043022,GO:0043167,GO:0043168,GO:0043934,GO:0044424,GO:0044464,GO:0044877,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0097159,GO:0097367,GO:1901265,GO:1901363 ko:K03979 ko00000,ko01000,ko03009 Bacteria 1TPX7@1239,4H9P8@91061,COG0536@1,COG0536@2 NA|NA|NA S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control MIPOCGNA_01634 322159.STER_1466 3.1e-133 481.1 Bacilli rsuA GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.19,5.4.99.22 ko:K06178,ko:K06183 ko00000,ko01000,ko03009 Bacteria 1TQZ2@1239,4H9VU@91061,COG1187@1,COG1187@2 NA|NA|NA J Belongs to the pseudouridine synthase RsuA family MIPOCGNA_01637 264199.stu1516 5.5e-65 253.4 Bacilli paaI ko:K02614 ko00360,map00360 R09840 RC00004,RC00014 ko00000,ko00001,ko01000 Bacteria 1VN0K@1239,4HM66@91061,COG2050@1,COG2050@2 NA|NA|NA Q protein possibly involved in aromatic compounds catabolism MIPOCGNA_01638 322159.STER_1470 6.7e-50 203.0 Bacteria ycaO ko:K06889,ko:K07397,ko:K09136 ko00000,ko03009 Bacteria COG1765@1,COG1765@2 NA|NA|NA O OsmC-like protein MIPOCGNA_01640 264199.stu1517 3.2e-153 547.7 Firmicutes Bacteria 1TYSF@1239,COG0697@1,COG0697@2 NA|NA|NA EG Permeases of the drug metabolite transporter (DMT) superfamily MIPOCGNA_01642 264199.stu1519 5.3e-113 413.7 Bacilli serB 3.1.3.3 ko:K01079 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R00582 RC00017 ko00000,ko00001,ko00002,ko01000,ko01009 Bacteria 1V9R7@1239,4HTNE@91061,COG0560@1,COG0560@2 NA|NA|NA E phosphoserine phosphatase MIPOCGNA_01643 264199.stu1520 9.6e-303 1045.4 Bacilli ezrA GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0000918,GO:0000921,GO:0005575,GO:0005623,GO:0005886,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0022402,GO:0022607,GO:0031106,GO:0032185,GO:0032506,GO:0034622,GO:0043933,GO:0044085,GO:0044464,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051301,GO:0051302,GO:0051781,GO:0061640,GO:0065003,GO:0065007,GO:0070925,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047 ko:K06286,ko:K07158 ko00000,ko03036 Bacteria 1TQR7@1239,4HA15@91061,COG4477@1,COG4477@2 NA|NA|NA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization MIPOCGNA_01644 264199.stu1521 0.0 1273.8 Bacilli gyrB GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 5.99.1.3 ko:K02470,ko:K02622 ko00000,ko01000,ko02048,ko03032,ko03036,ko03400 Bacteria 1TQ0R@1239,4H9Y6@91061,COG0187@1,COG0187@2 NA|NA|NA L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner MIPOCGNA_01645 264199.stu1522 1.6e-97 362.1 Bacilli 3.1.3.18 ko:K01091,ko:K07025 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 R01334 RC00017 ko00000,ko00001,ko01000 Bacteria 1V421@1239,4HHYH@91061,COG0546@1,COG0546@2 NA|NA|NA S IA, variant 1 MIPOCGNA_01646 322159.STER_1482 2.2e-117 428.3 Bacilli lrgB Bacteria 1TRGN@1239,4HF0M@91061,COG1346@1,COG1346@2 NA|NA|NA M effector of murein hydrolase MIPOCGNA_01647 322159.STER_1483 7.7e-56 223.0 Firmicutes lrgA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K06518 ko00000,ko02000 1.E.14.2 Bacteria 1VEN4@1239,COG1380@1,COG1380@2 NA|NA|NA S Effector of murein hydrolase LrgA MIPOCGNA_01649 264199.stu1525 6.4e-60 236.5 Bacilli arsC 1.20.4.1 ko:K00537,ko:K16509 ko00000,ko01000 Bacteria 1VA5Q@1239,4HKQQ@91061,COG1393@1,COG1393@2 NA|NA|NA P Belongs to the ArsC family MIPOCGNA_01650 904306.HMPREF9192_0874 6.3e-57 226.5 Bacteria ogt GO:0003674,GO:0003824,GO:0003908,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 2.1.1.63,3.2.2.20 ko:K00567,ko:K01246 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria COG0350@1,COG0350@2 NA|NA|NA L methylated-DNA-[protein]-cysteine S-methyltransferase activity MIPOCGNA_01651 322159.STER_1487 7e-220 769.6 Bacilli serA 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1V410@1239,4H9PH@91061,COG0111@1,COG0111@2 NA|NA|NA EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family MIPOCGNA_01652 264199.stu1528 1.3e-104 385.6 Bacilli wecD Bacteria 1UIW7@1239,4ISU9@91061,COG1247@1,COG1247@2 NA|NA|NA M Acetyltransferase (GNAT) domain MIPOCGNA_01653 322159.STER_1489 5.1e-209 733.4 Bacilli serC GO:0003674,GO:0003824,GO:0004648,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 1TP6Y@1239,4HATT@91061,COG1932@1,COG1932@2 NA|NA|NA E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine MIPOCGNA_01654 264199.stu1530 1.2e-45 188.7 Bacilli Bacteria 1TRQ7@1239,4HE30@91061,COG1940@1,COG1940@2 NA|NA|NA GK ROK family MIPOCGNA_01655 264199.stu1530 1.6e-12 77.8 Bacilli Bacteria 1TRQ7@1239,4HE30@91061,COG1940@1,COG1940@2 NA|NA|NA GK ROK family MIPOCGNA_01656 264199.stu1532 8.1e-72 276.2 Bacilli gloA 4.4.1.5 ko:K01759,ko:K15772 ko00620,ko02010,map00620,map02010 M00491 R02530 RC00004,RC00740 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.1.16,3.A.1.1.2 Bacteria 1V6K3@1239,4HJ7X@91061,COG0346@1,COG0346@2 NA|NA|NA E Lactoylglutathione lyase MIPOCGNA_01657 264199.stu1533 6.6e-62 243.4 Bacteria XK27_08050 Bacteria COG0330@1,COG0330@2 NA|NA|NA O stress-induced mitochondrial fusion MIPOCGNA_01658 1046629.Ssal_00531 6.2e-13 79.0 Bacilli XK27_08050 Bacteria 1TPXU@1239,4HGRC@91061,COG0330@1,COG0330@2 NA|NA|NA O HflC and HflK could regulate a protease MIPOCGNA_01659 888049.HMPREF8578_1272 3.9e-75 287.3 Streptococcus oralis XK27_01300 Bacteria 1V6S0@1239,1WPM6@1303,4HKKR@91061,COG4405@1,COG4405@2 NA|NA|NA S ASCH MIPOCGNA_01661 861450.HMPREF0080_01875 7.3e-51 206.5 Negativicutes GO:0001666,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0036293,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0045926,GO:0045927,GO:0046483,GO:0048518,GO:0048519,GO:0050789,GO:0050896,GO:0065007,GO:0070482,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360 Bacteria 1VB8K@1239,4H5S1@909932,COG4679@1,COG4679@2 NA|NA|NA S Toxin-antitoxin system, toxin component, RelE family MIPOCGNA_01662 861450.HMPREF0080_01876 2e-29 134.8 Negativicutes ko:K15773 ko00000,ko02048,ko03000 Bacteria 1UM2Z@1239,4H69H@909932,COG1813@1,COG1813@2 NA|NA|NA K Helix-turn-helix XRE-family like proteins MIPOCGNA_01663 999425.HMPREF9186_01000 7.5e-09 66.6 Bacilli ko:K07124 ko00000 Bacteria 1TR8Z@1239,4H9ZH@91061,COG0300@1,COG0300@2 NA|NA|NA S Belongs to the short-chain dehydrogenases reductases (SDR) family MIPOCGNA_01664 663952.SDD27957_08275 1.1e-12 78.2 Streptococcus dysgalactiae group Bacteria 1M9X8@119603,1TXDE@1239,2DJ7U@1,304XK@2,4I6BD@91061 NA|NA|NA MIPOCGNA_01665 435842.HMPREF0848_00446 4.3e-167 594.3 Bacilli ko:K03327,ko:K18908 M00705 ko00000,ko00002,ko01504,ko02000 2.A.66.1,2.A.66.1.13 Bacteria 1V3MS@1239,4HI19@91061,COG0534@1,COG0534@2 NA|NA|NA V MatE MIPOCGNA_01667 435842.HMPREF0848_00444 3.9e-110 404.1 Bacilli ko:K07011,ko:K22227 ko00000 Bacteria 1TR52@1239,4HAY2@91061,COG0535@1,COG0535@2 NA|NA|NA C Fe-S oxidoreductases MIPOCGNA_01668 585203.SMSK564_1565 1.2e-176 625.9 Bacilli Bacteria 1VUFN@1239,4HVXJ@91061,COG0477@1,COG2814@2 NA|NA|NA EGP Major Facilitator Superfamily MIPOCGNA_01669 322159.STER_1356 5.5e-258 896.3 Bacteria Bacteria COG0535@1,COG0535@2 NA|NA|NA I radical SAM domain protein MIPOCGNA_01671 322159.STER_1358 3.2e-158 564.3 Bacilli Z012_04635 Bacteria 1UZI0@1239,4HC2C@91061,COG1396@1,COG1396@2 NA|NA|NA K Transcriptional activator, Rgg GadR MutR family MIPOCGNA_01672 322159.STER_1359 1.4e-150 538.9 Firmicutes ko:K07497 ko00000 Bacteria 1TQQY@1239,COG2801@1,COG2801@2 NA|NA|NA L Integrase core domain protein MIPOCGNA_01673 322159.STER_1360 1.8e-87 328.6 Bacteria ko:K07483 ko00000 Bacteria COG2963@1,COG2963@2 NA|NA|NA L transposase activity MIPOCGNA_01675 1035187.HMPREF9959_0071 1.9e-107 395.2 Streptococcus mitis Bacteria 1U48F@1239,2DKA2@1,2TNQ0@28037,30904@2,4IDZK@91061 NA|NA|NA MIPOCGNA_01676 1046629.Ssal_01001 7.4e-90 336.7 Bacilli Bacteria 1W0N0@1239,2FFHU@1,347FA@2,4HZDI@91061 NA|NA|NA MIPOCGNA_01677 1046629.Ssal_00531 4.5e-21 107.1 Bacilli XK27_08050 Bacteria 1TPXU@1239,4HGRC@91061,COG0330@1,COG0330@2 NA|NA|NA O HflC and HflK could regulate a protease MIPOCGNA_01679 264199.stu1535 2.3e-206 724.5 Bacilli potD ko:K11069 ko02010,map02010 M00299 ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 iSB619.SA_RS05395 Bacteria 1TPY1@1239,4HAET@91061,COG0687@1,COG0687@2 NA|NA|NA P spermidine putrescine ABC transporter MIPOCGNA_01680 322159.STER_1494 3e-134 484.6 Bacilli potC GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008519,GO:0015075,GO:0015101,GO:0015203,GO:0015399,GO:0015405,GO:0015417,GO:0015595,GO:0015606,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0015848,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072488,GO:0098533,GO:0098655,GO:0098796,GO:0098797,GO:1902047,GO:1902494,GO:1902495,GO:1903711,GO:1904949,GO:1990351 ko:K11070 ko02010,map02010 M00299 ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 iSBO_1134.SBO_1939 Bacteria 1V0VD@1239,4H9ZC@91061,COG1177@1,COG1177@2 NA|NA|NA P ABC-type spermidine putrescine transport system, permease component II MIPOCGNA_01681 264199.stu1537 3.7e-140 504.2 Bacilli potB ko:K11071 ko02010,map02010 M00299 ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 Bacteria 1TQ7Z@1239,4HAYS@91061,COG1176@1,COG1176@2 NA|NA|NA P ABC-type spermidine putrescine transport system, permease component I MIPOCGNA_01682 322159.STER_1496 1.2e-213 748.8 Bacilli potA 3.6.3.30,3.6.3.31 ko:K02010,ko:K11072 ko02010,map02010 M00190,M00299 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10,3.A.1.11.1 iSB619.SA_RS05380 Bacteria 1TP2M@1239,4H9MS@91061,COG3842@1,COG3842@2 NA|NA|NA P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system MIPOCGNA_01683 322159.STER_1497 7.8e-171 606.3 Bacilli murB 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 Bacteria 1TP3W@1239,4HAD8@91061,COG0812@1,COG0812@2 NA|NA|NA M cell wall formation MIPOCGNA_01684 322159.STER_1498 2.9e-87 327.8 Bacilli folK 2.7.6.3,4.1.2.25 ko:K00950,ko:K13940 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503,R03504 RC00002,RC00017,RC00721,RC00943 ko00000,ko00001,ko00002,ko01000 Bacteria 1V6PR@1239,4HIMG@91061,COG0801@1,COG0801@2 NA|NA|NA H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase MIPOCGNA_01685 322159.STER_1499 7.6e-61 239.6 Bacilli folB 1.13.11.81,2.5.1.15,2.7.6.3,4.1.2.25,5.1.99.8 ko:K00796,ko:K00950,ko:K01633,ko:K13940 ko00790,ko01100,map00790,map01100 M00126,M00840,M00841 R03066,R03067,R03503,R03504,R11037,R11073 RC00002,RC00017,RC00121,RC00721,RC00842,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 Bacteria 1VA0I@1239,4HKKK@91061,COG1539@1,COG1539@2 NA|NA|NA H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin MIPOCGNA_01686 264199.stu1542 3e-297 1026.9 Bacilli amy 3.2.1.1 ko:K01176 ko00500,ko01100,ko04973,map00500,map01100,map04973 R02108,R02112,R11262 ko00000,ko00001,ko01000 GH13 Bacteria 1TRKZ@1239,4HC8C@91061,COG0366@1,COG0366@2 NA|NA|NA G Belongs to the glycosyl hydrolase 13 family MIPOCGNA_01687 264199.stu1543 7e-147 526.6 Bacilli folP GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.15,2.7.6.3 ko:K00796,ko:K13941 ko00790,ko01100,map00790,map01100 M00126,M00840,M00841 R03066,R03067,R03503 RC00002,RC00017,RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS03115 Bacteria 1TPKT@1239,4H9SY@91061,COG0294@1,COG0294@2 NA|NA|NA H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives MIPOCGNA_01688 264199.stu1544 1e-99 369.4 Bacilli folE GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv3609c Bacteria 1TRNM@1239,4HAXS@91061,COG0302@1,COG0302@2 NA|NA|NA F gtp cyclohydrolase MIPOCGNA_01689 322159.STER_1503 0.0 1163.7 Bacilli ydaO GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015179,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015807,GO:0015849,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1902475,GO:1903825,GO:1905039 Bacteria 1TQE1@1239,4HAZH@91061,COG0531@1,COG0531@2 NA|NA|NA E amino acid MIPOCGNA_01690 264199.stu1546 5.5e-239 833.2 Bacilli folC 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0166 Bacteria 1TPX5@1239,4HBJM@91061,COG0285@1,COG0285@2 NA|NA|NA H Belongs to the folylpolyglutamate synthase family MIPOCGNA_01691 264199.stu1547 4.1e-37 160.2 Bacteria ylqC ko:K06960 ko00000 Bacteria COG1837@1,COG1837@2 NA|NA|NA L Belongs to the UPF0109 family MIPOCGNA_01692 1046629.Ssal_00517 2.4e-43 181.0 Bacilli rpsP GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02959 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011,ko03029 Bacteria 1VA0X@1239,4HKNN@91061,COG0228@1,COG0228@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bS16 family MIPOCGNA_01693 322159.STER_1507 6.9e-172 609.8 Bacilli tehB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0010035,GO:0016740,GO:0016741,GO:0032259,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0046690,GO:0050896 2.1.1.265 ko:K03647,ko:K16868 ko00000,ko01000 Bacteria 1TSZK@1239,4HJT1@91061,COG0500@1,COG0500@2,COG3615@1,COG3615@2 NA|NA|NA PQ tellurite resistance protein tehb MIPOCGNA_01694 264199.stu1550 1e-156 559.3 Bacilli xth GO:0003674,GO:0003824,GO:0003906,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008296,GO:0008309,GO:0008311,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.11.2 ko:K01142 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 1TPFB@1239,4HAIU@91061,COG0708@1,COG0708@2 NA|NA|NA L exodeoxyribonuclease III MIPOCGNA_01695 322159.STER_1509 2.1e-74 285.0 Firmicutes Bacteria 1V99E@1239,COG4708@1,COG4708@2 NA|NA|NA S QueT transporter MIPOCGNA_01696 264199.stu1552 1.7e-119 435.3 Bacilli ribD 1.1.1.193,3.5.4.26 ko:K00082,ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 iLJ478.TM1828 Bacteria 1UHQR@1239,4IS6G@91061,COG1985@1,COG1985@2 NA|NA|NA L Transposase DDE domain MIPOCGNA_01697 322159.STER_1512 1.9e-186 658.3 Bacilli yegS GO:0001727,GO:0003674,GO:0003824,GO:0004143,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0030258,GO:0044237,GO:0044238,GO:0044255,GO:0046834,GO:0071704 2.7.1.107 ko:K07029 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 R02240 RC00002,RC00017 ko00000,ko00001,ko01000 Bacteria 1TQAU@1239,4H9WD@91061,COG1597@1,COG1597@2 NA|NA|NA I Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase MIPOCGNA_01698 264199.stu1554 0.0 1238.4 Bacilli ligA GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 Bacteria 1TPQ3@1239,4HA1D@91061,COG0272@1,COG0272@2 NA|NA|NA L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA MIPOCGNA_01699 264199.stu1555 1.3e-85 322.4 Bacilli ccl GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 1V22G@1239,4HGG2@91061,COG4708@1,COG4708@2 NA|NA|NA S cog cog4708 MIPOCGNA_01700 322159.STER_1515 2.4e-159 568.2 Bacilli rbn ko:K07058 ko00000 Bacteria 1U7HM@1239,4H9MJ@91061,COG1295@1,COG1295@2 NA|NA|NA E Belongs to the UPF0761 family MIPOCGNA_01701 322159.STER_1516 7.2e-166 589.7 Bacilli map GO:0000096,GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006508,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009066,GO:0009987,GO:0010467,GO:0016151,GO:0016485,GO:0016787,GO:0019538,GO:0019752,GO:0030145,GO:0035551,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050897,GO:0051604,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0140096,GO:1901564,GO:1901605 3.4.11.18 ko:K01265 ko00000,ko01000,ko01002 Bacteria 1TQC1@1239,4H9S9@91061,COG0024@1,COG0024@2 NA|NA|NA E Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed MIPOCGNA_01702 322159.STER_1517 2.8e-230 804.3 Bacilli ytoI Bacteria 1TPU6@1239,4HB62@91061,COG4109@1,COG4109@2 NA|NA|NA K transcriptional regulator containing CBS domains MIPOCGNA_01703 322159.STER_1518 4.5e-97 360.5 Bacilli XK27_07830 2.3.1.128 ko:K03790 ko00000,ko01000,ko03009 Bacteria 1V576@1239,4HH6U@91061,COG1670@1,COG1670@2 NA|NA|NA J Acetyltransferase GNAT Family MIPOCGNA_01704 264199.stu1447 5e-45 186.8 Bacilli oppF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02032,ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 1V36J@1239,4HCM4@91061,COG4608@1,COG4608@2 NA|NA|NA P Belongs to the ABC transporter superfamily MIPOCGNA_01705 525379.HMPREF0819_1242 1.4e-40 171.8 Bacilli tatD GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575 ko:K03424 ko00000,ko01000 Bacteria 1TNY1@1239,4HA74@91061,COG0084@1,COG0084@2 NA|NA|NA L Hydrolase, tatd MIPOCGNA_01706 322159.STER_1416 9.9e-214 749.2 Bacilli oxlT ko:K08177 ko00000,ko02000 2.A.1.11 Bacteria 1TPR9@1239,4HB93@91061,COG2223@1,COG2223@2 NA|NA|NA P COG0477 Permeases of the major facilitator superfamily MIPOCGNA_01707 888048.HMPREF8577_0808 1.1e-75 289.3 Bacilli ko:K07497 ko00000 Bacteria 1TQQY@1239,4HC8M@91061,COG2801@1,COG2801@2 NA|NA|NA L Transposase and inactivated derivatives MIPOCGNA_01708 264199.stu1389 3.5e-106 391.0 Bacilli MA20_06410 Bacteria 1TRUX@1239,4HFB2@91061,COG1280@1,COG1280@2 NA|NA|NA E LysE type translocator MIPOCGNA_01709 491916.RHECIAT_PC0000880 1.9e-69 269.6 Rhizobiaceae Bacteria 1N5JR@1224,2VGXQ@28211,4BNNM@82115,COG0318@1,COG0318@2 NA|NA|NA IQ PFAM AMP-dependent synthetase and ligase MIPOCGNA_01713 862971.SANR_0567 6.7e-26 122.9 Streptococcus anginosus group Bacteria 1TVYK@1239,2DITH@1,3043M@2,42EF9@671232,4I4KQ@91061 NA|NA|NA S Bacteriocin class II with double-glycine leader peptide MIPOCGNA_01714 467705.SGO_1359 7.9e-100 370.2 Bacteria ko:K20373 ko02024,map02024 ko00000,ko00001,ko03000 Bacteria COG1396@1,COG1396@2 NA|NA|NA K sequence-specific DNA binding MIPOCGNA_01715 264199.stu1512 2e-11 74.7 Bacilli ko:K06871 ko00000 Bacteria 1TQPS@1239,4HCKJ@91061,COG0641@1,COG0641@2 NA|NA|NA C Arylsulfatase regulator (Fe-S oxidoreductase) MIPOCGNA_01716 322159.STER_1785 9.1e-225 785.8 Bacilli tgt GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 ko:K00773 R03789,R10209 RC00063 ko00000,ko01000,ko03016 Bacteria 1TNZ4@1239,4HCNM@91061,COG0343@1,COG0343@2 NA|NA|NA F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) MIPOCGNA_01717 264199.stu1386 8.5e-09 66.2 Bacilli Bacteria 1VBXK@1239,2CWIF@1,32SZQ@2,4HWJ5@91061 NA|NA|NA MIPOCGNA_01718 1321372.AQQB01000076_gene537 3.3e-30 137.1 Streptococcus suis Bacteria 1U996@1239,1WU2Q@1307,2B3ZK@1,31WPQ@2,4IJBS@91061 NA|NA|NA S Antidote-toxin recognition MazE, bacterial antitoxin MIPOCGNA_01719 1123299.AUKZ01000011_gene1075 1e-69 269.2 Bacilli doc ko:K07341 ko00000,ko02048 Bacteria 1VCC8@1239,4HKXW@91061,COG3654@1,COG3654@2 NA|NA|NA S Prophage maintenance system killer protein MIPOCGNA_01720 264199.stu0372 1e-165 589.3 Bacilli ppaC GO:0003674,GO:0003824,GO:0004427,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006793,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0044237,GO:0044424,GO:0044464 3.6.1.1 ko:K15986 ko00190,map00190 ko00000,ko00001,ko01000 Bacteria 1TPH6@1239,4H9T8@91061,COG1227@1,COG1227@2 NA|NA|NA C inorganic pyrophosphatase MIPOCGNA_01721 1158601.I585_02313 2.3e-27 128.3 Enterococcaceae Bacteria 1W4UE@1239,28X4W@1,2ZJ3B@2,4B3JU@81852,4I08E@91061 NA|NA|NA S Protein of unknown function (DUF2568) MIPOCGNA_01722 1215915.BN193_09415 1.8e-79 302.0 Lactococcus tnpR Bacteria 1UZM8@1239,1YCIK@1357,4IQDC@91061,COG1961@1,COG1961@2 NA|NA|NA L Resolvase, N terminal domain MIPOCGNA_01723 322159.STER_1413 4.1e-158 563.9 Bacilli ko:K07497 ko00000 Bacteria 1TU21@1239,4HDK4@91061,COG2801@1,COG2801@2 NA|NA|NA L COG2801 Transposase and inactivated derivatives MIPOCGNA_01724 272623.L137335 8.1e-45 186.0 Bacilli ko:K07483 ko00000 Bacteria 1VE7W@1239,4HKEI@91061,COG2963@1,COG2963@2 NA|NA|NA L Transposase MIPOCGNA_01725 264199.stu0828 2.5e-94 351.3 Bacilli queF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016651,GO:0016657,GO:0018130,GO:0019438,GO:0033739,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.7.1.13 ko:K06879,ko:K09457 ko00790,ko01100,map00790,map01100 R07605 RC01875 ko00000,ko00001,ko01000,ko03016 iSFV_1184.SFV_2663,iSF_1195.SF2807,iS_1188.S3002 Bacteria 1TPYC@1239,4HB14@91061,COG0780@1,COG0780@2 NA|NA|NA S Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily MIPOCGNA_01726 264199.stu0827 3.9e-133 480.7 Bacilli queE GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008144,GO:0016829,GO:0016840,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:1901681,GO:1904047 1.97.1.4,4.3.99.3 ko:K04068,ko:K10026 ko00790,ko01100,map00790,map01100 R04710,R10002 RC02989 ko00000,ko00001,ko01000,ko03016 Bacteria 1TQ58@1239,4HAJ3@91061,COG0602@1,COG0602@2 NA|NA|NA H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds MIPOCGNA_01727 264199.stu0826 2.2e-81 308.1 Bacilli queD 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 Bacteria 1V9HU@1239,4HJEX@91061,COG0720@1,COG0720@2 NA|NA|NA H synthase MIPOCGNA_01728 1046629.Ssal_00963 2.2e-122 444.9 Bacilli queC 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 R09978 RC00959 ko00000,ko00001,ko01000,ko03016 Bacteria 1TP4Z@1239,4HB1Y@91061,COG0603@1,COG0603@2 NA|NA|NA F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) MIPOCGNA_01729 264199.stu0824 3e-63 247.7 Bacilli tdcF 3.5.99.10 ko:K09022 R11098,R11099 RC03275,RC03354 ko00000,ko01000 Bacteria 1V6HG@1239,4HKEF@91061,COG0251@1,COG0251@2 NA|NA|NA J endoribonuclease L-PSP MIPOCGNA_01730 888833.HMPREF9421_1356 3.3e-201 707.6 Bacilli pmrB Bacteria 1V6VB@1239,4IT0A@91061,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily MIPOCGNA_01731 562983.HMPREF0433_01645 3.7e-19 101.3 Bacilli Bacteria 1W2BC@1239,2DF7W@1,2ZQU2@2,4HZFK@91061 NA|NA|NA MIPOCGNA_01732 264199.stu0818 3.5e-260 903.7 Bacilli asnS GO:0003674,GO:0003824,GO:0004812,GO:0004816,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006421,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.22 ko:K01893 ko00970,map00970 M00359,M00360 R03648 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1TP38@1239,4H9YH@91061,COG0017@1,COG0017@2 NA|NA|NA J Catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA MIPOCGNA_01733 264199.stu0817 1.6e-216 758.4 Bacilli aspB GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769,GO:0047297 2.6.1.1,2.6.1.14 ko:K00812,ko:K22457 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 R00355,R00694,R00734,R00896,R01346,R02433,R02619,R05052 RC00006,RC00025 ko00000,ko00001,ko01000,ko01007 iHN637.CLJU_RS06550 Bacteria 1TP0J@1239,4HA13@91061,COG0436@1,COG0436@2 NA|NA|NA E Aminotransferase MIPOCGNA_01734 322159.STER_0862 3.1e-81 307.8 Bacilli ypmB Bacteria 1VA2H@1239,4HNMM@91061,COG5353@1,COG5353@2 NA|NA|NA S Protein conserved in bacteria MIPOCGNA_01735 904306.HMPREF9192_1246 0.0 1501.5 Bacilli dinG GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7,3.6.4.12 ko:K02342,ko:K03722 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 1TQHQ@1239,4HB2Y@91061,COG1199@1,COG1199@2,COG2176@1,COG2176@2 NA|NA|NA L helicase involved in DNA repair and perhaps also replication MIPOCGNA_01736 264199.stu0812 2e-120 438.3 Bacilli ycbL GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019243,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0051596,GO:0061727,GO:0071704,GO:1901575,GO:1901615 3.1.2.6 ko:K01069 ko00620,map00620 R01736 RC00004,RC00137 ko00000,ko00001,ko01000 Bacteria 1V6FA@1239,4HHRQ@91061,COG0491@1,COG0491@2 NA|NA|NA S COG0491 Zn-dependent hydrolases, including glyoxylases MIPOCGNA_01737 264199.stu0811 1e-168 599.4 Bacilli yufQ ko:K02057 M00221 ko00000,ko00002,ko02000 3.A.1.2 Bacteria 1TP8Y@1239,4HAX4@91061,COG1079@1,COG1079@2 NA|NA|NA S Belongs to the binding-protein-dependent transport system permease family MIPOCGNA_01738 322159.STER_0858 8.9e-190 669.5 Bacilli yufP GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0044425,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944 ko:K02057 M00221 ko00000,ko00002,ko02000 3.A.1.2 Bacteria 1TP1F@1239,4H9VE@91061,COG4603@1,COG4603@2 NA|NA|NA S Belongs to the binding-protein-dependent transport system permease family MIPOCGNA_01739 322159.STER_0857 5.4e-281 973.0 Bacilli xylG 3.6.3.17 ko:K02056,ko:K06400 M00221 ko00000,ko00002,ko01000,ko02000 3.A.1.2 Bacteria 1UYQA@1239,4HVSH@91061,COG3845@1,COG3845@2 NA|NA|NA S ABC transporter, ATP-binding protein MIPOCGNA_01740 322159.STER_0856 5.8e-189 666.8 Bacilli tcsA ko:K02058,ko:K07335 M00221 ko00000,ko00002,ko02000 3.A.1.2 Bacteria 1TPEU@1239,4HANH@91061,COG1744@1,COG1744@2 NA|NA|NA S ABC-type transport system, periplasmic component surface lipoprotein MIPOCGNA_01741 322159.STER_0855 2.2e-47 194.5 Bacilli cdd 2.4.2.2,3.5.4.5 ko:K00756,ko:K01489 ko00240,ko00983,ko01100,map00240,map00983,map01100 R01570,R01876,R01878,R02296,R02484,R02485,R08221 RC00063,RC00074,RC00514 ko00000,ko00001,ko01000 iSB619.SA_RS07895 Bacteria 1V6IP@1239,4HIJ3@91061,COG0295@1,COG0295@2 NA|NA|NA F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis MIPOCGNA_01742 264199.stu0806 3.2e-38 164.5 Bacilli deoC GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 4.1.2.4,5.4.2.8 ko:K01619,ko:K01840 ko00030,ko00051,ko00520,ko01100,ko01110,ko01130,map00030,map00051,map00520,map01100,map01110,map01130 M00114 R01066,R01818 RC00408,RC00436,RC00437 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS00835 Bacteria 1TPAJ@1239,4HAAJ@91061,COG0274@1,COG0274@2 NA|NA|NA F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate MIPOCGNA_01743 264199.stu0804 2.3e-43 181.4 Bacteria pdp GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016757,GO:0016758,GO:0044424,GO:0044444,GO:0044464 2.4.2.2,2.4.2.4 ko:K00756,ko:K00758 ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219 R01570,R01876,R02296,R02484,R08222,R08230 RC00063 ko00000,ko00001,ko01000 Bacteria COG0213@1,COG0213@2 NA|NA|NA F phosphorylase activity MIPOCGNA_01744 1046629.Ssal_00947 7.1e-59 233.4 Bacilli pdp GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016757,GO:0016758,GO:0044424,GO:0044444,GO:0044464 2.4.2.2,2.4.2.4 ko:K00756,ko:K00758 ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219 R01570,R01876,R02296,R02484,R08222,R08230 RC00063 ko00000,ko00001,ko01000 Bacteria 1TPCH@1239,4H9NP@91061,COG0213@1,COG0213@2 NA|NA|NA F Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate MIPOCGNA_01745 264199.stu0802 3e-23 113.6 Bacteria pdp GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016757,GO:0016758,GO:0044424,GO:0044444,GO:0044464 2.4.2.2,2.4.2.4 ko:K00756,ko:K00758 ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219 R01570,R01876,R02296,R02484,R08222,R08230 RC00063 ko00000,ko00001,ko01000 Bacteria COG0213@1,COG0213@2 NA|NA|NA F phosphorylase activity MIPOCGNA_01746 1046629.Ssal_00947 9.3e-35 152.5 Bacilli pdp GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016757,GO:0016758,GO:0044424,GO:0044444,GO:0044464 2.4.2.2,2.4.2.4 ko:K00756,ko:K00758 ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219 R01570,R01876,R02296,R02484,R08222,R08230 RC00063 ko00000,ko00001,ko01000 Bacteria 1TPCH@1239,4H9NP@91061,COG0213@1,COG0213@2 NA|NA|NA F Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate MIPOCGNA_01747 322159.STER_0852 3.7e-105 387.5 Bacilli rsmC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044464 2.1.1.172 ko:K00564 R07234 RC00003 ko00000,ko01000,ko03009 Bacteria 1V3JX@1239,4IR00@91061,COG2813@1,COG2813@2 NA|NA|NA J Methyltransferase small domain protein MIPOCGNA_01748 264199.stu0799 5.5e-172 610.1 Bacilli coaA GO:0003674,GO:0003824,GO:0004594,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.33 ko:K00867 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 iECDH1ME8569_1439.ECDH1ME8569_3838,iECH74115_1262.ECH74115_5439,iECSE_1348.ECSE_4265,iECSF_1327.ECSF_3833,iECSP_1301.ECSP_5045,iECW_1372.ECW_m4332,iEcDH1_1363.EcDH1_4016,iEcolC_1368.EcolC_4046,iPC815.YPO3758,iSFV_1184.SFV_4047,iSFxv_1172.SFxv_4418,iWFL_1372.ECW_m4332,iZ_1308.Z5545 Bacteria 1TPHJ@1239,4HA4K@91061,COG1072@1,COG1072@2 NA|NA|NA F Pantothenic acid kinase MIPOCGNA_01749 264199.stu0798 2.1e-30 137.9 Bacteria rpsT GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02968 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria COG0268@1,COG0268@2 NA|NA|NA J rRNA binding MIPOCGNA_01750 264199.stu0796 5.5e-135 486.9 Firmicutes Bacteria 1TQEG@1239,COG2801@1,COG2801@2 NA|NA|NA L integrase core domain MIPOCGNA_01751 264199.stu0797 2.6e-52 211.1 Bacilli ko:K07483 ko00000 Bacteria 1V2T5@1239,4HFZ1@91061,COG2963@1,COG2963@2 NA|NA|NA L Transposase MIPOCGNA_01752 264199.stu0797 1.2e-21 108.2 Bacilli ko:K07483 ko00000 Bacteria 1V2T5@1239,4HFZ1@91061,COG2963@1,COG2963@2 NA|NA|NA L Transposase MIPOCGNA_01759 322159.STER_1649 7.4e-135 486.5 Bacteria agrA ko:K07707 ko02020,ko02024,map02020,map02024 M00495 ko00000,ko00001,ko00002,ko02022 Bacteria COG3279@1,COG3279@2 NA|NA|NA KT phosphorelay signal transduction system MIPOCGNA_01760 322159.STER_1650 9.9e-239 832.4 Bacteria blpH 2.7.13.3 ko:K07706 ko02020,ko02024,map02020,map02024 M00495 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria COG3290@1,COG3290@2 NA|NA|NA T protein histidine kinase activity MIPOCGNA_01762 322159.STER_1652 7.3e-237 826.2 Bacilli mesE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K20345 ko02024,map02024 ko00000,ko00001,ko02000 3.A.1.112,8.A.1 Bacteria 1V5C8@1239,4HHKB@91061,COG0845@1,COG0845@2 NA|NA|NA M Transport protein ComB MIPOCGNA_01763 322159.STER_1653 0.0 1373.2 Bacilli comA ko:K06147,ko:K06148,ko:K20344 ko02010,ko02024,map02010,map02024 ko00000,ko00001,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.112,3.A.1.21 Bacteria 1V77J@1239,4HAX2@91061,COG2274@1,COG2274@2 NA|NA|NA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain MIPOCGNA_01764 264199.stu1693 0.0 1084.7 Bacilli mdlB GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008144,GO:0008150,GO:0010876,GO:0015399,GO:0015405,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0033036,GO:0034040,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043492,GO:0044425,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363 ko:K06147,ko:K18890 ko02010,map02010 M00707 ko00000,ko00001,ko00002,ko02000 3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21 Bacteria 1TP0B@1239,4HA3S@91061,COG1132@1,COG1132@2 NA|NA|NA V abc transporter atp-binding protein MIPOCGNA_01765 264199.stu1694 0.0 1109.7 Bacilli mdlA GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0016021,GO:0017076,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044425,GO:0044464,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363 ko:K06148,ko:K18889 ko02010,map02010 M00707 ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.106.13,3.A.1.106.5 Bacteria 1TP0B@1239,4HA3S@91061,COG1132@1,COG1132@2 NA|NA|NA V abc transporter atp-binding protein MIPOCGNA_01767 264199.stu1695 1.7e-93 348.6 Bacilli XK27_09885 Bacteria 1VKIA@1239,4HQZW@91061,COG4767@1,COG4767@2 NA|NA|NA V Glycopeptide antibiotics resistance protein MIPOCGNA_01768 322159.STER_1660 3e-223 780.8 Bacilli rlmN GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 ko:K06941 ko00000,ko01000,ko03009 Bacteria 1TPVF@1239,4H9NU@91061,COG0820@1,COG0820@2 NA|NA|NA J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs MIPOCGNA_01769 322159.STER_1661 2.4e-66 258.8 Bacilli yutD Bacteria 1VA85@1239,4HKF7@91061,COG4470@1,COG4470@2 NA|NA|NA J protein conserved in bacteria MIPOCGNA_01770 322159.STER_1662 9e-267 925.6 Bacilli yunD 3.1.3.5 ko:K01081 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 Bacteria 1TQCW@1239,4HAUC@91061,COG0737@1,COG0737@2 NA|NA|NA F Belongs to the 5'-nucleotidase family MIPOCGNA_01772 322159.STER_1664 1.4e-221 775.4 Bacilli cshB GO:0000166,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0008026,GO:0008144,GO:0008150,GO:0008152,GO:0008186,GO:0009266,GO:0009295,GO:0009409,GO:0009628,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0070035,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901363 3.6.4.13 ko:K05592,ko:K18692 ko03018,map03018 ko00000,ko00001,ko01000,ko03009,ko03019 Bacteria 1TPAP@1239,4HA98@91061,COG0513@1,COG0513@2 NA|NA|NA JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures MIPOCGNA_01773 322159.STER_1665 6.3e-185 653.3 Bacilli mraY GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 iAF987.Gmet_0409,iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105 Bacteria 1TP8W@1239,4H9TP@91061,COG0472@1,COG0472@2 NA|NA|NA M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan MIPOCGNA_01774 322159.STER_1666 0.0 1455.7 Bacilli ftsI GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031226,GO:0031406,GO:0032153,GO:0033218,GO:0033293,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:1901363,GO:1901681 3.4.16.4 ko:K03587,ko:K08384,ko:K08724,ko:K12552,ko:K12556 ko00550,ko01100,ko01501,map00550,map01100,map01501 ko00000,ko00001,ko01000,ko01011,ko03036 iSSON_1240.SSON_0092 Bacteria 1TP93@1239,4H9VQ@91061,COG0768@1,COG0768@2 NA|NA|NA M penicillin-binding protein MIPOCGNA_01775 322159.STER_1667 4.3e-47 193.7 Bacilli ftsL Bacteria 1VCE5@1239,4HM4W@91061,COG4839@1,COG4839@2 NA|NA|NA D cell division protein FtsL MIPOCGNA_01776 322159.STER_1668 3e-157 561.2 Bacilli rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 ko00000,ko01000,ko03009 Bacteria 1TNZV@1239,4H9U2@91061,COG0275@1,COG0275@2 NA|NA|NA J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA MIPOCGNA_01777 264199.stu1704 1.6e-65 255.4 Bacilli Bacteria 1W5UA@1239,2DDKD@1,2ZIF1@2,4HZND@91061 NA|NA|NA MIPOCGNA_01778 264199.stu1704 7.4e-27 125.9 Bacilli Bacteria 1W5UA@1239,2DDKD@1,2ZIF1@2,4HZND@91061 NA|NA|NA MIPOCGNA_01779 264199.stu1704 7.5e-30 136.7 Bacilli Bacteria 1W5UA@1239,2DDKD@1,2ZIF1@2,4HZND@91061 NA|NA|NA MIPOCGNA_01780 1046629.Ssal_00333 8.7e-33 146.4 Bacilli yhaI Bacteria 1V90R@1239,4HQ7Q@91061,COG3152@1,COG3152@2 NA|NA|NA J Protein of unknown function (DUF805) MIPOCGNA_01781 435842.HMPREF0848_01480 4.5e-18 97.1 Bacteria Bacteria COG1196@1,COG1196@2 NA|NA|NA D nuclear chromosome segregation MIPOCGNA_01782 322159.STER_1675 2e-225 788.1 Bacilli proA GO:0003674,GO:0003824,GO:0004350,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0055114,GO:0055129,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 iB21_1397.B21_00243,iECBD_1354.ECBD_3376,iECB_1328.ECB_00240,iECD_1391.ECD_00240,iLJ478.TM0293,iYL1228.KPN_00280,iYO844.BSU13130 Bacteria 1TQ9V@1239,4HB7B@91061,COG0014@1,COG0014@2 NA|NA|NA E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate MIPOCGNA_01783 904306.HMPREF9192_0659 2.6e-141 508.1 Bacilli proB GO:0003674,GO:0003824,GO:0004349,GO:0004350,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016491,GO:0016620,GO:0016740,GO:0016772,GO:0016774,GO:0016903,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPG6@1239,4HA9B@91061,COG0263@1,COG0263@2 NA|NA|NA E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate MIPOCGNA_01784 322159.STER_1677 2e-286 991.1 Bacilli XK27_00765 ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TSZA@1239,28MBB@1,2ZAPV@2,4HDKH@91061 NA|NA|NA MIPOCGNA_01785 1046629.Ssal_00328 8.1e-134 483.0 Bacilli ecsA_2 ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TQIH@1239,4HCEU@91061,COG1131@1,COG1131@2 NA|NA|NA V abc transporter atp-binding protein MIPOCGNA_01786 1046629.Ssal_00327 7.6e-12 75.5 Bacilli ko:K07150 ko00000 Bacteria 1TQWV@1239,4HEYY@91061,COG1811@1,COG1811@2 NA|NA|NA S Protein of unknown function (DUF554) MIPOCGNA_01787 904306.HMPREF9192_0656 3.1e-99 367.9 Bacilli ko:K07150 ko00000 Bacteria 1TQWV@1239,4HEYY@91061,COG1811@1,COG1811@2 NA|NA|NA S Protein of unknown function (DUF554) MIPOCGNA_01788 264199.stu1716 0.0 2331.2 Bacilli addA 3.6.4.12 ko:K16898 ko00000,ko01000,ko03400 Bacteria 1TQ35@1239,4HA64@91061,COG1074@1,COG1074@2 NA|NA|NA L ATP-dependent helicase nuclease subunit A MIPOCGNA_01789 264199.stu1717 0.0 2133.2 Bacilli rexB GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0004518,GO:0004519,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.21.3,3.6.4.12 ko:K01153,ko:K16899 ko00000,ko01000,ko02048,ko03400 Bacteria 1TQJW@1239,4HAY6@91061,COG3857@1,COG3857@2 NA|NA|NA L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination MIPOCGNA_01790 435842.HMPREF0848_01378 2.4e-55 221.5 Bacilli liaI ko:K11619 ko02020,map02020 M00754 ko00000,ko00001,ko00002 Bacteria 1VGSF@1239,4IRBC@91061,COG4758@1,COG4758@2 NA|NA|NA S membrane MIPOCGNA_01791 435842.HMPREF0848_01379 2.7e-09 67.0 Bacilli XK27_02470 Bacteria 1VBF7@1239,4HHGZ@91061,COG3279@1,COG3279@2 NA|NA|NA K LytTr DNA-binding domain protein MIPOCGNA_01792 1046629.Ssal_00311 3e-53 214.5 Bacteria Bacteria COG4640@1,COG4640@2 NA|NA|NA KT response to antibiotic MIPOCGNA_01793 1046629.Ssal_00311 1.4e-08 65.5 Bacteria Bacteria COG4640@1,COG4640@2 NA|NA|NA KT response to antibiotic MIPOCGNA_01794 1046629.Ssal_00311 9.1e-18 95.1 Bacteria Bacteria COG4640@1,COG4640@2 NA|NA|NA KT response to antibiotic MIPOCGNA_01795 435842.HMPREF0848_01381 9.8e-80 303.5 Bacilli yebC ko:K16637 ko00000,ko02042 Bacteria 1VK5M@1239,4HS44@91061,COG3064@1,COG3064@2 NA|NA|NA M Membrane MIPOCGNA_01796 1046629.Ssal_00310 1.1e-16 92.0 Bacilli yebC ko:K16637 ko00000,ko02042 Bacteria 1VK5M@1239,4HS44@91061,COG3064@1,COG3064@2 NA|NA|NA M Membrane MIPOCGNA_01797 904306.HMPREF9192_0643 1.2e-258 898.7 Bacilli XK27_03190 ko:K16785 ko02010,map02010 M00582 ko00000,ko00001,ko00002,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 Bacteria 1TSZZ@1239,4HB54@91061,COG0561@1,COG0561@2,COG4696@1,COG4696@2 NA|NA|NA S hydrolases of the HAD superfamily MIPOCGNA_01798 264199.stu1724 1.5e-172 612.1 Bacilli ansA 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 R00485 RC00010,RC02798 ko00000,ko00001,ko01000 Bacteria 1TPP9@1239,4H9YJ@91061,COG0252@1,COG0252@2 NA|NA|NA EJ COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D MIPOCGNA_01799 322159.STER_1700 0.0 1315.1 Bacilli recG GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 ko:K03655 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 1TQ6I@1239,4HAWN@91061,COG1200@1,COG1200@2 NA|NA|NA L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) MIPOCGNA_01800 322159.STER_1701 1.8e-185 655.2 Bacilli alr 5.1.1.1,5.1.1.5 ko:K01775,ko:K20707 ko00473,ko01100,ko01502,map00473,map01100,map01502 R00401 RC00285 ko00000,ko00001,ko01000,ko01011 Bacteria 1TNYY@1239,4HA95@91061,COG0787@1,COG0787@2 NA|NA|NA E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids MIPOCGNA_01801 322159.STER_1702 3.1e-62 244.2 Bacilli acpS 2.7.6.3,2.7.8.7,5.1.1.1 ko:K00950,ko:K00997,ko:K01775 ko00473,ko00770,ko00790,ko01100,ko01502,map00473,map00770,map00790,map01100,map01502 M00126,M00841 R00401,R01625,R03503 RC00002,RC00017,RC00285 ko00000,ko00001,ko00002,ko01000,ko01011 iYO844.BSU04620 Bacteria 1VA0T@1239,4HKBI@91061,COG0736@1,COG0736@2 NA|NA|NA I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein MIPOCGNA_01802 322159.STER_1703 2.5e-197 694.5 Firmicutes aroF 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS07240 Bacteria 1TQI4@1239,COG0722@1,COG0722@2 NA|NA|NA E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) MIPOCGNA_01803 322159.STER_1704 3.8e-198 697.2 Firmicutes aroF 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS07240 Bacteria 1TQI4@1239,COG0722@1,COG0722@2 NA|NA|NA E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) MIPOCGNA_01804 264199.stu1730 0.0 1656.0 Bacilli secA GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 Bacteria 1TPEY@1239,4HA22@91061,COG0653@1,COG0653@2 NA|NA|NA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane MIPOCGNA_01806 264199.stu1732 3e-189 667.5 Bacilli manA 5.3.1.8 ko:K01809 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01819 RC00376 ko00000,ko00001,ko00002,ko01000 Bacteria 1VRGI@1239,4HBFW@91061,COG1482@1,COG1482@2 NA|NA|NA G mannose-6-phosphate isomerase MIPOCGNA_01807 264199.stu1733 5.2e-130 470.3 Bacilli scrK 2.7.1.2,2.7.1.4 ko:K00845,ko:K00847 ko00010,ko00051,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R00760,R00867,R01600,R01786,R03920 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQU4@1239,4HA1C@91061,COG1940@1,COG1940@2 NA|NA|NA GK Fructokinase MIPOCGNA_01808 322159.STER_1959 8.2e-27 125.9 Bacilli Bacteria 1VENK@1239,4HNKV@91061,COG2261@1,COG2261@2 NA|NA|NA S Membrane MIPOCGNA_01809 1117379.BABA_02482 1.1e-116 426.0 Bacillus ko:K07497 ko00000 Bacteria 1TU21@1239,1ZB1J@1386,4HDK4@91061,COG2801@1,COG2801@2 NA|NA|NA L COG2801 Transposase and inactivated derivatives MIPOCGNA_01810 322159.STER_1757 9.7e-43 179.1 Bacteria ko:K07483 ko00000 Bacteria COG2963@1,COG2963@2 NA|NA|NA L transposase activity MIPOCGNA_01811 322159.STER_0016 2.9e-18 97.8 Firmicutes ko:K07483 ko00000 Bacteria 1W68S@1239,COG2963@1,COG2963@2 NA|NA|NA L Transposase MIPOCGNA_01812 416870.llmg_0717 7e-124 449.9 Lactococcus tnp ko:K07498 ko00000 Bacteria 1UTIC@1239,1YC0H@1357,4HCF1@91061,COG3316@1,COG3316@2 NA|NA|NA L DDE domain MIPOCGNA_01813 322159.STER_0458 2.6e-64 251.1 Bacilli WQ51_03320 Bacteria 1VHA6@1239,4HPTC@91061,COG4835@1,COG4835@2 NA|NA|NA S cog cog4835 MIPOCGNA_01814 904306.HMPREF9192_0332 2.4e-44 184.5 Bacilli XK27_08360 Bacteria 1TRM7@1239,4HVKJ@91061,COG1307@1,COG1307@2 NA|NA|NA S EDD domain protein, DegV family MIPOCGNA_01815 264199.stu0423 7.8e-86 323.2 Firmicutes XK27_08360 Bacteria 1TRM7@1239,COG1307@1,COG1307@2 NA|NA|NA T EDD domain protein, DegV family MIPOCGNA_01816 264199.stu0424 4.3e-138 497.3 Bacilli dapB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0070402,GO:0070404,GO:0071704,GO:0071944,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 iJN678.dapB,iNJ661.Rv2773c,iYO844.BSU22490 Bacteria 1TR9D@1239,4HA5X@91061,COG0289@1,COG0289@2 NA|NA|NA E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate MIPOCGNA_01817 264199.stu0425 9e-223 779.2 Bacilli cca 2.7.7.19,2.7.7.72 ko:K00970,ko:K00974 ko03013,ko03018,map03013,map03018 R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016,ko03019 Bacteria 1TQ2A@1239,4HB2W@91061,COG0617@1,COG0617@2 NA|NA|NA J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate MIPOCGNA_01818 322159.STER_0462 0.0 1186.8 Bacilli yfmR ko:K15738 ko00000,ko02000 3.A.1.120.6 Bacteria 1TPAX@1239,4H9TK@91061,COG0488@1,COG0488@2 NA|NA|NA S abc transporter atp-binding protein MIPOCGNA_01819 1123298.KB904062_gene886 3.3e-25 121.7 Bacteria Bacteria COG3247@1,COG3247@2 NA|NA|NA U response to pH MIPOCGNA_01820 322159.STER_0465 3e-139 501.1 Bacilli 3.6.1.13,3.6.1.55 ko:K01515,ko:K03574 ko00230,map00230 R01054 RC00002 ko00000,ko00001,ko01000,ko03400 Bacteria 1TST7@1239,4HEFP@91061,COG1051@1,COG1051@2 NA|NA|NA F AdP-ribose pyrophosphatase MIPOCGNA_01821 264199.stu0429 3.4e-208 730.7 Bacilli nadD 2.7.1.22,2.7.7.1,2.7.7.18,3.6.1.55 ko:K00969,ko:K03574,ko:K06211 ko00760,ko01100,map00760,map01100 M00115 R00137,R02324,R03005 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko03000,ko03400 iIT341.HP1337 Bacteria 1TQ29@1239,4HBZT@91061,COG1057@1,COG1057@2,COG3172@1,COG3172@2 NA|NA|NA H adenylyltransferase MIPOCGNA_01822 264199.stu0430 6.9e-256 889.4 Bacilli gdhA 1.4.1.4 ko:K00262 ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100 R00248 RC00006,RC02799 ko00000,ko00001,ko01000 Bacteria 1TP45@1239,4HAEI@91061,COG0334@1,COG0334@2 NA|NA|NA E Belongs to the Glu Leu Phe Val dehydrogenases family MIPOCGNA_01823 322159.STER_0468 8.7e-69 266.2 Bacilli def_1 3.5.1.31,3.5.1.88 ko:K01450,ko:K01462 ko00270,ko00630,map00270,map00630 R00653 RC00165,RC00323 ko00000,ko00001,ko01000 Bacteria 1V73T@1239,4HGYC@91061,COG0242@1,COG0242@2 NA|NA|NA J Removes the formyl group from the N-terminal Met of newly synthesized proteins MIPOCGNA_01824 264199.stu0432 1.6e-76 292.0 Bacteria Bacteria COG1846@1,COG1846@2 NA|NA|NA K DNA-binding transcription factor activity MIPOCGNA_01825 264199.stu0433 0.0 1078.9 Bacilli lmrA1 ko:K02021,ko:K06147,ko:K06148,ko:K18887 ko02010,map02010 M00706 ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21 Bacteria 1TP0B@1239,4H9SC@91061,COG1132@1,COG1132@2 NA|NA|NA V abc transporter atp-binding protein MIPOCGNA_01826 264199.stu0434 0.0 1102.8 Bacilli lmrA2 ko:K06147 ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 1TP0B@1239,4HA3S@91061,COG1132@1,COG1132@2 NA|NA|NA V abc transporter atp-binding protein MIPOCGNA_01827 1046629.Ssal_01762 1.1e-49 202.6 Bacilli Bacteria 1VF01@1239,4HPKN@91061,COG0454@1,COG0456@2 NA|NA|NA K Acetyltransferase (GNAT) family MIPOCGNA_01828 904306.HMPREF9192_0347 2.7e-27 127.5 Bacilli 2.7.6.5 ko:K00951,ko:K07816 ko00230,map00230 R00429 RC00002,RC00078 ko00000,ko00001,ko01000 Bacteria 1TQ2F@1239,4HTR5@91061,COG2357@1,COG2357@2 NA|NA|NA S Region found in RelA / SpoT proteins MIPOCGNA_01829 904306.HMPREF9192_0347 2.6e-28 130.6 Bacilli 2.7.6.5 ko:K00951,ko:K07816 ko00230,map00230 R00429 RC00002,RC00078 ko00000,ko00001,ko01000 Bacteria 1TQ2F@1239,4HTR5@91061,COG2357@1,COG2357@2 NA|NA|NA S Region found in RelA / SpoT proteins MIPOCGNA_01830 904306.HMPREF9192_0348 7.9e-32 142.9 Bacilli Bacteria 1TPU2@1239,4HG2E@91061,COG0745@1,COG0745@2 NA|NA|NA T response regulator MIPOCGNA_01831 904306.HMPREF9192_0348 2.8e-28 130.6 Bacilli Bacteria 1TPU2@1239,4HG2E@91061,COG0745@1,COG0745@2 NA|NA|NA T response regulator MIPOCGNA_01833 435842.HMPREF0848_00055 1.1e-13 82.0 Bacilli sptS 2.7.13.3 ko:K11328 ko02020,map02020 M00464 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1UHQH@1239,4HAHG@91061,COG0642@1,COG0642@2 NA|NA|NA T Histidine kinase MIPOCGNA_01834 264199.stu0437 4.3e-107 394.0 Bacilli sptS 2.7.13.3 ko:K11328 ko02020,map02020 M00464 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1UHQH@1239,4HAHG@91061,COG0642@1,COG0642@2 NA|NA|NA T Histidine kinase MIPOCGNA_01835 322159.STER_0474 4.9e-131 473.8 Bacilli pyrH GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006225,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009163,GO:0009165,GO:0009185,GO:0009188,GO:0009193,GO:0009194,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0033862,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042455,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046048,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 R00158 RC00002 ko00000,ko00001,ko01000 iSB619.SA_RS06240 Bacteria 1TPXN@1239,4H9UB@91061,COG0528@1,COG0528@2 NA|NA|NA F Catalyzes the reversible phosphorylation of UMP to UDP MIPOCGNA_01836 322159.STER_0475 1.3e-91 342.4 Bacilli frr GO:0002181,GO:0002184,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0030312,GO:0032984,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02838 ko00000,ko03012 Bacteria 1V1F2@1239,4HFSH@91061,COG0233@1,COG0233@2 NA|NA|NA J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another MIPOCGNA_01837 322159.STER_0476 7e-161 573.2 Bacilli cvfB ko:K00243 ko00000 Bacteria 1TQ1Z@1239,4HDAZ@91061,COG2996@1,COG2996@2 NA|NA|NA S Protein conserved in bacteria MIPOCGNA_01838 264199.stu0441 7.4e-35 152.5 Bacilli yozE Bacteria 1VFI4@1239,4HR7P@91061,COG4479@1,COG4479@2 NA|NA|NA S Belongs to the UPF0346 family MIPOCGNA_01839 264199.stu0442 4.2e-120 438.3 Bacteria usp 3.5.1.104,3.5.1.28 ko:K15125,ko:K17733,ko:K21449,ko:K21471,ko:K22278,ko:K22409 ko05133,map05133 ko00000,ko00001,ko00536,ko01000,ko01002,ko01011,ko02000 1.B.40.2 CBM50 Bacteria COG1388@1,COG1388@2,COG3942@1,COG3942@2 NA|NA|NA S pathogenesis MIPOCGNA_01840 264199.stu0446 2.6e-61 241.5 Bacilli rlpA ko:K03642 ko00000 Bacteria 1V61Q@1239,4HHT0@91061,COG1388@1,COG1388@2 NA|NA|NA M LysM domain protein MIPOCGNA_01841 322159.STER_0480 2.3e-190 671.4 Bacilli phoH GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K06217 ko00000 Bacteria 1TP35@1239,4HBD5@91061,COG1702@1,COG1702@2 NA|NA|NA T phosphate starvation-inducible protein PhoH MIPOCGNA_01845 264199.stu0451 0.0 1342.8 Bacilli metG GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10,6.1.1.20 ko:K01874,ko:K01890,ko:K06878 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R03660,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1TPA1@1239,4H9VC@91061,COG0073@1,COG0073@2,COG0143@1,COG0143@2 NA|NA|NA J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation MIPOCGNA_01846 904306.HMPREF9192_0361 9.2e-164 582.8 Bacilli Bacteria 1V53I@1239,4HIEU@91061,COG0583@1,COG0583@2 NA|NA|NA K transcriptional regulator (lysR family) MIPOCGNA_01847 322159.STER_0488 1.4e-186 658.7 Bacilli coiA 3.6.4.12 ko:K03657,ko:K06198 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 1TRGD@1239,4HFP5@91061,COG4469@1,COG4469@2 NA|NA|NA S Competence protein MIPOCGNA_01848 322159.STER_0489 0.0 1194.5 Bacilli pepF GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006465,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0051604,GO:0070011,GO:0071704,GO:0140096,GO:1901564 ko:K08602 ko00000,ko01000,ko01002 Bacteria 1TP4P@1239,4HA7X@91061,COG1164@1,COG1164@2 NA|NA|NA E oligoendopeptidase F MIPOCGNA_01849 264199.stu0455 7.1e-127 459.9 Bacilli yrrM 2.1.1.104 ko:K00588 ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110 M00039,M00350 R01942,R06578 RC00003,RC00392 ko00000,ko00001,ko00002,ko01000 Bacteria 1UF4M@1239,4HE9E@91061,COG4122@1,COG4122@2 NA|NA|NA S O-Methyltransferase MIPOCGNA_01850 322159.STER_0492 3.9e-167 594.3 Bacteria prsA 3.1.3.16,5.2.1.8 ko:K01802,ko:K03769,ko:K07533,ko:K20074 ko00000,ko01000,ko01009,ko03110 Bacteria COG0760@1,COG0760@2 NA|NA|NA O peptidyl-prolyl cis-trans isomerase activity MIPOCGNA_01851 264199.stu0457 0.0 1717.6 Bacilli alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1TPK6@1239,4H9XC@91061,COG0013@1,COG0013@2 NA|NA|NA J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain MIPOCGNA_01852 322159.STER_0495 2.5e-146 525.0 Bacilli 3.4.17.14,3.5.1.28 ko:K01448,ko:K07260,ko:K21471 ko00550,ko01100,ko01502,ko01503,ko02020,map00550,map01100,map01502,map01503,map02020 M00651,M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504,ko03036 Bacteria 1W25V@1239,4HGXW@91061,COG0860@1,COG0860@2,COG3942@1,COG3942@2 NA|NA|NA M GBS Bsp-like repeat MIPOCGNA_01853 264199.stu0461 1.9e-39 169.1 Bacteria 3.4.17.14,3.5.1.28 ko:K01448,ko:K02395,ko:K07260 ko00550,ko01100,ko01502,ko01503,ko02020,map00550,map01100,map01502,map01503,map02020 M00651,M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504,ko02035,ko03036 Bacteria COG1705@1,COG1705@2 NA|NA|NA NU amidase activity MIPOCGNA_01854 264199.stu0461 1.3e-30 138.3 Bacteria 3.4.17.14,3.5.1.28 ko:K01448,ko:K02395,ko:K07260 ko00550,ko01100,ko01502,ko01503,ko02020,map00550,map01100,map01502,map01503,map02020 M00651,M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504,ko02035,ko03036 Bacteria COG1705@1,COG1705@2 NA|NA|NA NU amidase activity MIPOCGNA_01855 264199.stu0462 4.9e-145 520.4 Bacilli cnhA 3.5.1.3 ko:K11206,ko:K13566 ko00250,map00250 R00269,R00348 RC00010 ko00000,ko00001,ko01000 Bacteria 1TQDK@1239,4HC44@91061,COG0388@1,COG0388@2 NA|NA|NA S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase MIPOCGNA_01856 322159.STER_0499 1.7e-226 791.6 Bacilli mtnE 2.6.1.83 ko:K08969,ko:K10206 ko00270,ko00300,ko01100,ko01110,ko01130,ko01230,map00270,map00300,map01100,map01110,map01130,map01230 M00034,M00527 R07396,R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 1TQD6@1239,4HAHQ@91061,COG0436@1,COG0436@2 NA|NA|NA E mutations do not affect methionine salvage in vivo however MIPOCGNA_01857 264199.stu0464 1.4e-189 668.7 Bacilli argC GO:0003674,GO:0003824,GO:0003942,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 iLJ478.TM1782,iSSON_1240.SSON_4131,iYO844.BSU11190 Bacteria 1TPVI@1239,4H9YD@91061,COG0002@1,COG0002@2 NA|NA|NA E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde MIPOCGNA_01858 322159.STER_0501 1.5e-222 778.5 Bacilli argJ GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35,2.7.2.8 ko:K00620,ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282,R02649 RC00002,RC00004,RC00043,RC00064 ko00000,ko00001,ko00002,ko01000 iLJ478.TM1783 Bacteria 1TPBP@1239,4H9TQ@91061,COG1364@1,COG1364@2 NA|NA|NA E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate MIPOCGNA_01859 264199.stu0466 1.3e-128 465.7 Firmicutes argB GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP0N@1239,COG0548@1,COG0548@2 NA|NA|NA E Belongs to the acetylglutamate kinase family. ArgB subfamily MIPOCGNA_01860 322159.STER_0503 4.5e-208 730.3 Bacilli argD GO:0003674,GO:0003824,GO:0003992,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 1TP9S@1239,4H9VZ@91061,COG4992@1,COG4992@2 NA|NA|NA E acetylornithine aminotransferase MIPOCGNA_01861 322159.STER_0504 3.6e-128 464.5 Bacilli yxkH Bacteria 1V6AW@1239,4HHC9@91061,COG0726@1,COG0726@2 NA|NA|NA G deacetylase MIPOCGNA_01862 264199.stu0469 4e-237 827.0 Bacilli hom GO:0003674,GO:0003824,GO:0004412,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.3,2.7.2.4 ko:K00003,ko:K12524 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00017,M00018,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1294,iSB619.SA_RS06610 Bacteria 1TQ2H@1239,4HBAP@91061,COG0460@1,COG0460@2 NA|NA|NA E homoserine dehydrogenase MIPOCGNA_01863 1046629.Ssal_01693 2.1e-149 535.0 Bacilli thrB GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.1.39 ko:K00872 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 iECSE_1348.ECSE_0003,iJN678.thrB,iLJ478.TM0545 Bacteria 1TRWS@1239,4HCQN@91061,COG0083@1,COG0083@2 NA|NA|NA E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate MIPOCGNA_01864 264199.stu0471 1e-151 542.7 Bacilli rarD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016021,GO:0031224,GO:0044425,GO:0044464,GO:0071944 ko:K05786 ko00000,ko02000 2.A.7.7 Bacteria 1TQF2@1239,4HAYU@91061,COG2962@1,COG2962@2 NA|NA|NA S Transporter MIPOCGNA_01865 1123315.AUIP01000020_gene2219 2.6e-16 92.4 Bacteria Bacteria COG3212@1,COG3212@2 NA|NA|NA T peptidase MIPOCGNA_01866 1123314.AUIO01000005_gene141 8.9e-14 82.4 Bacilli coiA 3.6.4.12 ko:K03657,ko:K06198 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 1TRGD@1239,4HFP5@91061,COG4469@1,COG4469@2 NA|NA|NA S Competence protein MIPOCGNA_01867 322159.STER_0511 2.3e-99 368.2 Bacilli Bacteria 1VENC@1239,4HQ31@91061,COG1853@1,COG1853@2 NA|NA|NA S COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family MIPOCGNA_01868 1035189.HMPREF9954_2024 1.1e-96 359.4 Streptococcus infantis 2.3.1.128,5.2.1.8 ko:K03768,ko:K03790 ko00000,ko01000,ko03009,ko03110 Bacteria 1V2C6@1239,43F7Y@68892,4HG3C@91061,COG1670@1,COG1670@2 NA|NA|NA J Acetyltransferase (GNAT) domain MIPOCGNA_01869 1231377.C426_1192 2.5e-16 92.8 Lactococcus endA ko:K15051 ko00000 Bacteria 1V4X2@1239,1YC93@1357,4HIF5@91061,COG2169@1,COG2169@2 NA|NA|NA F DNA/RNA non-specific endonuclease MIPOCGNA_01870 322159.STER_0513 0.0 1741.5 Bacilli valS GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iLJ478.TM1817 Bacteria 1TPN4@1239,4HB85@91061,COG0525@1,COG0525@2 NA|NA|NA J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner MIPOCGNA_01871 1123298.KB904069_gene1213 1.4e-16 91.7 Bacteria atpE GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 Bacteria 2ZI0B@2,COG0636@1 NA|NA|NA C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation MIPOCGNA_01872 322159.STER_0516 1.6e-123 448.7 Bacilli atpB GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 iAPECO1_1312.APECO1_2725,iE2348C_1286.E2348C_4048,iEC042_1314.EC042_4125,iECABU_c1320.ECABU_c42230,iECED1_1282.ECED1_4428,iECIAI39_1322.ECIAI39_4342,iECNA114_1301.ECNA114_3887,iECOK1_1307.ECOK1_4187,iECP_1309.ECP_3937,iECS88_1305.ECS88_4160,iECSF_1327.ECSF_3586,iECUMN_1333.ECUMN_4268,iEcSMS35_1347.EcSMS35_4106,iLF82_1304.LF82_0192,iNRG857_1313.NRG857_18615,iUMN146_1321.UM146_18880,iUMNK88_1353.UMNK88_4550,iUTI89_1310.UTI89_C4293,ic_1306.c4666 Bacteria 1TQIT@1239,4H9NV@91061,COG0356@1,COG0356@2 NA|NA|NA C it plays a direct role in the translocation of protons across the membrane MIPOCGNA_01873 264199.stu0480 2.3e-76 291.6 Firmicutes atpF ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 iHN637.CLJU_RS01170,iYO844.BSU36850 Bacteria 1V74A@1239,COG0711@1,COG0711@2 NA|NA|NA C ATP synthase F(0) sector subunit b MIPOCGNA_01874 264199.stu0481 1e-85 322.8 Bacilli atpH GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 iSF_1195.SF3815,iSFxv_1172.SFxv_4157,iS_1188.S3953 Bacteria 1VAG3@1239,4HKW1@91061,COG0712@1,COG0712@2 NA|NA|NA C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation MIPOCGNA_01875 264199.stu0482 2.5e-278 964.1 Bacilli atpA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 iIT341.HP1134,iSB619.SA_RS10975,iSbBS512_1146.SbBS512_E4187 Bacteria 1TNZ8@1239,4HAMZ@91061,COG0056@1,COG0056@2 NA|NA|NA C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit MIPOCGNA_01876 264199.stu0483 6.2e-157 560.1 Bacilli atpG GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 iLJ478.TM1611,iSB619.SA_RS10970,iYO844.BSU36820 Bacteria 1TPBX@1239,4HB0E@91061,COG0224@1,COG0224@2 NA|NA|NA C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex MIPOCGNA_01877 322159.STER_0521 3.9e-262 910.2 Bacilli atpD 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 iSB619.SA_RS10965 Bacteria 1TPGF@1239,4HAT6@91061,COG0055@1,COG0055@2 NA|NA|NA C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits MIPOCGNA_01878 264199.stu0485 2e-52 211.8 Bacilli atpC GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 iJN746.PP_5412,iSbBS512_1146.SbBS512_E4190 Bacteria 1VA89@1239,4HKHS@91061,COG0355@1,COG0355@2 NA|NA|NA C Produces ATP from ADP in the presence of a proton gradient across the membrane MIPOCGNA_01879 264199.stu0486 7.5e-228 796.2 Bacilli ftsW ko:K03588 ko04112,map04112 ko00000,ko00001,ko02000,ko03036 2.A.103.1 Bacteria 1TPT7@1239,4HAEV@91061,COG0772@1,COG0772@2 NA|NA|NA D Belongs to the SEDS family MIPOCGNA_01880 264199.stu0487 3.6e-224 783.9 Bacilli tuf GO:0001817,GO:0001819,GO:0002791,GO:0002793,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009274,GO:0009275,GO:0009986,GO:0010339,GO:0016020,GO:0022610,GO:0030312,GO:0032677,GO:0032757,GO:0032879,GO:0032880,GO:0035821,GO:0044003,GO:0044068,GO:0044403,GO:0044406,GO:0044419,GO:0044424,GO:0044426,GO:0044462,GO:0044464,GO:0044650,GO:0044651,GO:0048518,GO:0048522,GO:0050707,GO:0050708,GO:0050714,GO:0050715,GO:0050789,GO:0050794,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051222,GO:0051223,GO:0051239,GO:0051240,GO:0051701,GO:0051704,GO:0051817,GO:0065007,GO:0070201,GO:0071944,GO:0090087,GO:1903530,GO:1903532,GO:1904951,GO:2000482,GO:2000484 ko:K02358,ko:K15771 ko02010,map02010 M00491 ko00000,ko00001,ko00002,ko02000,ko03012,ko03029,ko04147 3.A.1.1.16,3.A.1.1.2 Bacteria 1TPKC@1239,4HAEH@91061,COG0050@1,COG0050@2 NA|NA|NA J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis MIPOCGNA_01881 264199.stu0488 3.4e-135 487.6 Bacilli tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 2.7.2.3,5.3.1.1 ko:K00927,ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01015,R01512 RC00002,RC00043,RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 iHN637.CLJU_RS19265 Bacteria 1TP2F@1239,4HAPT@91061,COG0149@1,COG0149@2 NA|NA|NA G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) MIPOCGNA_01882 264199.stu0489 3.7e-111 407.5 Bacilli tmk GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS02535 Bacteria 1V1HE@1239,4HGWR@91061,COG0125@1,COG0125@2 NA|NA|NA F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis MIPOCGNA_01883 904306.HMPREF9192_0406 1.1e-156 559.3 Bacilli holB 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 1TRVS@1239,4HA3T@91061,COG0470@1,COG0470@2 NA|NA|NA L dna polymerase iii MIPOCGNA_01884 904306.HMPREF9192_0407 8e-135 486.5 Bacilli yaaT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 Bacteria 1TP1V@1239,4H9M9@91061,COG1774@1,COG1774@2 NA|NA|NA S stage 0 sporulation protein MIPOCGNA_01885 264199.stu0492 2.8e-54 217.6 Bacilli yabA GO:0003674,GO:0005488,GO:0005515,GO:0042802 Bacteria 1VA1F@1239,4HKND@91061,COG4467@1,COG4467@2 NA|NA|NA L Involved in initiation control of chromosome replication MIPOCGNA_01886 264199.stu0493 2.7e-160 571.2 Bacilli rsmI GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.198 ko:K07056 ko00000,ko01000,ko03009 Bacteria 1TP6U@1239,4HAH8@91061,COG0313@1,COG0313@2 NA|NA|NA H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA MIPOCGNA_01887 1069533.Sinf_0020 3.4e-24 117.1 Firmicutes Bacteria 1TQ93@1239,COG3464@1,COG3464@2 NA|NA|NA L Transposase MIPOCGNA_01888 322159.STER_0765 3e-190 671.4 Bacilli 3.5.2.6 ko:K01467,ko:K17836 ko00311,ko01130,ko01501,ko02020,map00311,map01130,map01501,map02020 M00627,M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000,ko01504 Bacteria 1VHF8@1239,4HU1N@91061,COG2367@1,COG2367@2 NA|NA|NA V D-alanyl-D-alanine carboxypeptidase MIPOCGNA_01889 264199.stu0722 4.4e-115 420.6 Firmicutes pilD 3.4.23.43 ko:K02236,ko:K02506,ko:K02654 M00331,M00429 ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 Bacteria 1V91J@1239,COG1989@1,COG1989@2 NA|NA|NA NOU Bacterial Peptidase A24 N-terminal domain MIPOCGNA_01890 322159.STER_0767 3.2e-92 344.4 Bacilli dps ko:K04047 ko00000,ko03036 Bacteria 1VCVJ@1239,4HMBD@91061,COG0783@1,COG0783@2 NA|NA|NA P Belongs to the Dps family MIPOCGNA_01891 322159.STER_0768 4.4e-79 300.4 Bacilli perR GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 ko:K03711,ko:K09825 ko00000,ko03000 Bacteria 1V400@1239,4HHF8@91061,COG0735@1,COG0735@2 NA|NA|NA P Belongs to the Fur family MIPOCGNA_01892 264199.stu0727 1.9e-27 127.9 Bacilli yqgQ Bacteria 1VK83@1239,4HRG2@91061,COG4483@1,COG4483@2 NA|NA|NA S protein conserved in bacteria MIPOCGNA_01893 264199.stu0728 7.8e-177 626.3 Bacilli glk GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS07790 Bacteria 1TPKW@1239,4HBAU@91061,COG1940@1,COG1940@2 NA|NA|NA G Glucokinase MIPOCGNA_01894 264199.stu0729 0.0 1194.1 Bacilli typA GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840 ko:K06207 ko00000 Bacteria 1TQ5Y@1239,4HAQ6@91061,COG1217@1,COG1217@2 NA|NA|NA T GTP-binding protein TypA MIPOCGNA_01896 264199.stu0731 1.6e-252 878.2 Bacilli murD 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 Bacteria 1TQ3P@1239,4HA5P@91061,COG0771@1,COG0771@2 NA|NA|NA M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) MIPOCGNA_01897 264199.stu0732 3.9e-201 707.2 Bacilli murG 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 GT28 Bacteria 1TQFT@1239,4HBAQ@91061,COG0707@1,COG0707@2 NA|NA|NA M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) MIPOCGNA_01898 264199.stu0733 8.2e-170 603.2 Firmicutes divIB ko:K03589 ko04112,map04112 ko00000,ko00001,ko03036 Bacteria 1VHEY@1239,COG1589@1,COG1589@2 NA|NA|NA D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex MIPOCGNA_01899 264199.stu0734 1.2e-250 872.1 Bacilli ftsA GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032153,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0071944,GO:0098552,GO:0098562 ko:K03590 ko04112,map04112 ko00000,ko00001,ko03036,ko04812 Bacteria 1TP1Z@1239,4H9NF@91061,COG0849@1,COG0849@2 NA|NA|NA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring MIPOCGNA_01900 264199.stu0735 2.7e-236 824.3 Bacilli ftsZ GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0030428,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 ko:K03531 ko04112,map04112 ko00000,ko00001,ko02048,ko03036,ko04812 Bacteria 1TP6W@1239,4H9WZ@91061,COG0206@1,COG0206@2 NA|NA|NA D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity MIPOCGNA_01901 264199.stu0736 5.1e-122 443.7 Bacilli ylmE GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 ko:K06997 ko00000 Bacteria 1TRDN@1239,4HC45@91061,COG0325@1,COG0325@2 NA|NA|NA S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis MIPOCGNA_01902 322159.STER_0779 1.4e-96 359.0 Bacteria sepF GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0022402,GO:0022607,GO:0032506,GO:0042802,GO:0044085,GO:0044464,GO:0051301,GO:0071840,GO:0071944,GO:0090529 ko:K09772 ko00000,ko03036 Bacteria COG1799@1,COG1799@2 NA|NA|NA D cell septum assembly MIPOCGNA_01903 322159.STER_0780 9.7e-34 149.1 Bacteria yggT GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02221 ko00000,ko02044 Bacteria COG0762@1,COG0762@2 NA|NA|NA D integral membrane protein MIPOCGNA_01904 264199.stu0739 8e-143 513.1 Bacteria ylmH ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 Bacteria COG2302@1,COG2302@2 NA|NA|NA T S4 RNA-binding domain MIPOCGNA_01905 322159.STER_0782 9.7e-134 483.0 Bacilli divIVA ko:K04074 ko00000,ko03036 Bacteria 1V27M@1239,4HJYN@91061,COG3599@1,COG3599@2 NA|NA|NA D Cell division protein DivIVA MIPOCGNA_01906 264199.stu0741 0.0 1871.7 Bacilli ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iG2583_1286.G2583_0027,iPC815.YPO0475 Bacteria 1TPS7@1239,4HAWB@91061,COG0060@1,COG0060@2 NA|NA|NA J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) MIPOCGNA_01907 322159.STER_0786 7.9e-230 802.7 Bacilli mntH Bacteria 1V04N@1239,4HBF6@91061,COG1914@1,COG1914@2 NA|NA|NA P Mn2 and Fe2 transporters of the NRAMP family MIPOCGNA_01908 1214166.ALLG01000032_gene234 4.1e-242 843.6 Streptococcus suis ltrA_1 Bacteria 1TP9A@1239,1WU2A@1307,4H9NW@91061,COG3344@1,COG3344@2 NA|NA|NA L Reverse transcriptase (RNA-dependent DNA polymerase) MIPOCGNA_01909 264199.stu0746 2e-45 188.0 Bacilli rpmE2 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0034224,GO:0034641,GO:0034645,GO:0042594,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0120127,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02909 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1VEGU@1239,4HNQF@91061,COG0254@1,COG0254@2 NA|NA|NA J 50S ribosomal protein L31 MIPOCGNA_01910 264199.stu0747 1.2e-174 619.0 Bacilli apbE 2.7.1.180 ko:K03734 ko00000,ko01000 Bacteria 1TR9C@1239,4HDFE@91061,COG1477@1,COG1477@2 NA|NA|NA H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein MIPOCGNA_01911 264199.stu0748 7.6e-177 626.3 Bacilli nrnA GO:0008150,GO:0040007 3.1.13.3,3.1.3.7 ko:K06881 ko00920,ko01100,ko01120,map00920,map01100,map01120 R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03400 Bacteria 1TPXX@1239,4H9ZW@91061,COG0618@1,COG0618@2 NA|NA|NA S domain protein MIPOCGNA_01912 322159.STER_0790 2.6e-154 551.2 Bacilli gst ko:K11209 ko00000,ko01000 Bacteria 1TPZ7@1239,4HD0K@91061,COG0625@1,COG0625@2 NA|NA|NA O Glutathione S-transferase MIPOCGNA_01913 264199.stu0750 6.7e-187 659.8 Bacilli add 3.5.4.4 ko:K01488,ko:K02029 ko00230,ko01100,ko05340,map00230,map01100,map05340 M00236 R01560,R02556 RC00477 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3 iHN637.CLJU_RS13960 Bacteria 1U44B@1239,4HCES@91061,COG1816@1,COG1816@2 NA|NA|NA F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism MIPOCGNA_01914 264199.stu0751 3.5e-111 407.5 Bacilli tdk GO:0003674,GO:0003824,GO:0004797,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006259,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009120,GO:0009123,GO:0009124,GO:0009157,GO:0009162,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019136,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046104,GO:0046125,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0090304,GO:0090407,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.1.21 ko:K00857 ko00240,ko00983,ko01100,map00240,map00983,map01100 R01567,R02099,R08233 RC00002,RC00017 ko00000,ko00001,ko01000 iAF1260.b1238,iBWG_1329.BWG_1065,iECDH10B_1368.ECDH10B_1298,iECDH1ME8569_1439.ECDH1ME8569_1176,iEcDH1_1363.EcDH1_2411,iJO1366.b1238,iJR904.b1238,iPC815.YPO2176,iY75_1357.Y75_RS06470 Bacteria 1TRVM@1239,4HA4A@91061,COG1435@1,COG1435@2 NA|NA|NA F thymidine kinase MIPOCGNA_01915 264199.stu0752 1.8e-190 671.8 Bacilli prfA ko:K02835 ko00000,ko03012 Bacteria 1TQ7V@1239,4H9MB@91061,COG0216@1,COG0216@2 NA|NA|NA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA MIPOCGNA_01916 322159.STER_0794 6.8e-153 546.6 Bacilli prmB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006304,GO:0006305,GO:0006306,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009007,GO:0009008,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0032775,GO:0034641,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0044728,GO:0046483,GO:0071704,GO:0090304,GO:0140096,GO:0140097,GO:1901360,GO:1901564 2.1.1.297,2.1.1.298 ko:K02493,ko:K07320 R10806 RC00003,RC03279 ko00000,ko01000,ko03009,ko03012 Bacteria 1TSMA@1239,4HC6W@91061,COG2890@1,COG2890@2 NA|NA|NA J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif MIPOCGNA_01917 264199.stu0754 2.5e-109 401.4 Bacilli ywlC GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 2.7.7.87,3.1.3.48 ko:K01104,ko:K07566 R10463 RC00745 ko00000,ko01000,ko03009,ko03016 Bacteria 1TP1I@1239,4HA7W@91061,COG0009@1,COG0009@2 NA|NA|NA J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine MIPOCGNA_01918 322159.STER_0796 3.4e-233 813.9 Bacilli glyA 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQVM@1239,4HA5K@91061,COG0112@1,COG0112@2 NA|NA|NA E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism MIPOCGNA_01919 264199.stu0756 1.3e-174 619.0 Bacilli ndpA GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003723,GO:0003727,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0009295,GO:0042802,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044464,GO:0097159,GO:1901363 ko:K06899 ko00000,ko03036 Bacteria 1V437@1239,4IQXJ@91061,COG3081@1,COG3081@2 NA|NA|NA S 37-kD nucleoid-associated bacterial protein MIPOCGNA_01920 264199.stu0757 8e-100 369.8 Bacteria pvaA ko:K02395 ko00000,ko02035 Bacteria COG0741@1,COG0741@2 NA|NA|NA M lytic transglycosylase activity MIPOCGNA_01921 322159.STER_0799 6.5e-307 1059.3 Bacilli yfiB1 ko:K06147,ko:K06148,ko:K18887 ko02010,map02010 M00706 ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 1TP0B@1239,4H9SC@91061,COG1132@1,COG1132@2 NA|NA|NA V abc transporter atp-binding protein MIPOCGNA_01922 322159.STER_0800 9.7e-311 1072.0 Bacilli XK27_10035 ko:K06147,ko:K11085 ko02010,map02010 ko00000,ko00001,ko01000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 1TP0B@1239,4HCVN@91061,COG1132@1,COG1132@2 NA|NA|NA V abc transporter atp-binding protein MIPOCGNA_01923 1000570.HMPREF9966_1459 1.3e-09 68.2 Streptococcus anginosus group Bacteria 1TW0K@1239,2DIU2@1,3044G@2,42EHI@671232,4I4PC@91061 NA|NA|NA S D-Ala-teichoic acid biosynthesis protein MIPOCGNA_01924 264199.stu0761 6e-296 1022.7 Bacilli dltA GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0006810,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016208,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0022857,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0051179,GO:0051234,GO:0055085,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.13 ko:K03367 ko00473,ko01503,ko02020,ko05150,map00473,map01503,map02020,map05150 M00725 R02718 RC00037,RC00094 ko00000,ko00001,ko00002,ko01000,ko01504 Bacteria 1TPTH@1239,4HAHU@91061,COG1020@1,COG1020@2 NA|NA|NA Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall MIPOCGNA_01925 264199.stu0762 1.6e-235 821.6 Bacilli dltB ko:K03739 ko01503,ko02020,ko05150,map01503,map02020,map05150 M00725 ko00000,ko00001,ko00002,ko01504 Bacteria 1TP52@1239,4HBQG@91061,COG1696@1,COG1696@2 NA|NA|NA M Membrane protein involved in D-alanine export MIPOCGNA_01926 264199.stu0763 2.2e-35 154.5 Bacilli dltC GO:0000270,GO:0003674,GO:0005215,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0006810,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0022857,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0051179,GO:0051234,GO:0055085,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.1.1.13 ko:K02078,ko:K14188 ko00473,ko01503,ko02020,ko05150,map00473,map01503,map02020,map05150 M00725 R02718 RC00037,RC00094 ko00000,ko00001,ko00002,ko01000,ko01504 Bacteria 1VFQI@1239,4HNIH@91061,COG0236@1,COG0236@2 NA|NA|NA IQ Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall MIPOCGNA_01927 322159.STER_0805 4.4e-228 797.0 Bacilli dltD ko:K03740 ko01503,ko02020,ko05150,map01503,map02020,map05150 M00725 ko00000,ko00001,ko00002,ko01504 Bacteria 1TSZU@1239,4HC3H@91061,COG3966@1,COG3966@2 NA|NA|NA M Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) MIPOCGNA_01928 264199.stu1787 4.9e-57 226.9 Firmicutes ko:K07497 ko00000 Bacteria 1TQQY@1239,COG2801@1,COG2801@2 NA|NA|NA L Integrase core domain protein MIPOCGNA_01929 322159.STER_0055 3.7e-18 96.7 Bacteria ko:K07483 ko00000 Bacteria COG2963@1,COG2963@2 NA|NA|NA L transposase activity MIPOCGNA_01930 435842.HMPREF0848_01320 3.6e-39 167.2 Bacilli ko:K07483 ko00000 Bacteria 1VDX9@1239,4HRT2@91061,COG2963@1,COG2963@2 NA|NA|NA L Transposase MIPOCGNA_01931 264199.stu0770 0.0 1632.1 Bacilli 3.6.3.8 ko:K01537,ko:K12955 ko00000,ko01000 3.A.3.2,3.A.3.24 Bacteria 1TPF5@1239,4H9S5@91061,COG0474@1,COG0474@2 NA|NA|NA P cation transport ATPase MIPOCGNA_01932 264199.stu0771 0.0 1138.6 Bacilli pabB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.6.1.85,4.1.3.27,4.1.3.38 ko:K01665,ko:K02619,ko:K03342,ko:K13503,ko:K13950 ko00400,ko00790,ko01100,ko01110,ko01130,ko01230,map00400,map00790,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01716,R05553 RC00010,RC01418,RC01843,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 1TQAP@1239,4HBKC@91061,COG0115@1,COG0115@2,COG0147@1,COG0147@2 NA|NA|NA EH component I MIPOCGNA_01934 264199.stu0785 0.0 1493.8 Bacilli metE GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003871,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0030312,GO:0032259,GO:0034641,GO:0035999,GO:0036211,GO:0040007,GO:0042084,GO:0042085,GO:0042558,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0050667,GO:0051186,GO:0071704,GO:0071944,GO:0140096,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 iE2348C_1286.E2348C_4130,iECO103_1326.ECO103_4334,iECO111_1330.ECO111_4657,iECO26_1355.ECO26_4756,iECW_1372.ECW_m4131,iEKO11_1354.EKO11_4528,iPC815.YPO3788,iWFL_1372.ECW_m4131 Bacteria 1TP2H@1239,4H9QC@91061,COG0620@1,COG0620@2 NA|NA|NA E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation MIPOCGNA_01935 264199.stu0786 2.1e-165 588.2 Bacilli metF GO:0000166,GO:0003674,GO:0003824,GO:0004489,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019438,GO:0019752,GO:0022607,GO:0034641,GO:0036094,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.5.1.20 ko:K00297,ko:K21010 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,ko02025,map00670,map00720,map01100,map01120,map01200,map01523,map02025 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 iPC815.YPO0117,iSBO_1134.SBO_3961 Bacteria 1TQFE@1239,4HGHI@91061,COG0685@1,COG0685@2 NA|NA|NA C reductase MIPOCGNA_01936 322159.STER_0833 0.0 1116.3 Bacilli pgm GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 5.4.2.2,5.4.2.8 ko:K01835,ko:K01840 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114,M00549 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP2N@1239,4HADU@91061,COG1109@1,COG1109@2 NA|NA|NA G Phosphoglucomutase MIPOCGNA_01937 264199.stu0788 1.1e-93 349.4 Bacilli panT GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 1V2M1@1239,4HFPD@91061,COG4684@1,COG4684@2 NA|NA|NA S ECF transporter, substrate-specific component MIPOCGNA_01938 264199.stu0789 2.8e-91 341.3 Bacilli coaBC 4.1.1.36,6.3.2.5 ko:K01598,ko:K13038,ko:K21977 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPP3@1239,4HAK8@91061,COG0452@1,COG0452@2 NA|NA|NA H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine MIPOCGNA_01939 264199.stu0790 2.8e-120 438.0 Bacilli coaB 4.1.1.36,6.3.2.5 ko:K01598,ko:K13038,ko:K21977 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 Bacteria 1V7YG@1239,4HMIF@91061,COG0452@1,COG0452@2 NA|NA|NA H Phosphopantothenate-cysteine ligase MIPOCGNA_01940 322159.STER_0837 0.0 1093.2 Bacilli fhs GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP6N@1239,4HA2X@91061,COG2759@1,COG2759@2 NA|NA|NA F Belongs to the formate--tetrahydrofolate ligase family MIPOCGNA_01941 904306.HMPREF9192_1233 1.2e-118 432.6 Bacilli Bacteria 1V295@1239,4HG3X@91061,COG0745@1,COG0745@2 NA|NA|NA T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain MIPOCGNA_01942 904306.HMPREF9192_1234 4.1e-43 180.6 Bacilli Bacteria 1UHNC@1239,4IS4A@91061,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor MIPOCGNA_01943 264199.stu0795 1.7e-120 438.7 Bacilli Bacteria 1UHNC@1239,4IS4A@91061,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor MIPOCGNA_01944 435842.HMPREF0848_00743 2e-129 468.4 Bacilli budA GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0047605 4.1.1.5 ko:K01575 ko00650,ko00660,map00650,map00660 R02948 RC00812 ko00000,ko00001,ko01000 Bacteria 1V4AH@1239,4HJ98@91061,COG3527@1,COG3527@2 NA|NA|NA H Belongs to the alpha-acetolactate decarboxylase family MIPOCGNA_01945 322159.STER_0940 0.0 1105.1 Bacilli alsS 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQE8@1239,4HAV1@91061,COG0028@1,COG0028@2 NA|NA|NA EH Belongs to the TPP enzyme family MIPOCGNA_01946 1121864.OMO_01537 6.6e-61 241.5 Bacteria ko:K08218 ko01501,map01501 M00628 ko00000,ko00001,ko00002,ko02000 2.A.1.25 Bacteria COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily MIPOCGNA_01947 264199.stu0921 3.9e-136 490.7 Bacteria speB 3.5.3.11 ko:K01480 ko00330,ko01100,map00330,map01100 M00133 R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 Bacteria COG0010@1,COG0010@2 NA|NA|NA E hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines MIPOCGNA_01948 264199.stu0920 1.1e-212 745.7 Firmicutes pqqE Bacteria 1TR52@1239,COG0535@1,COG0535@2 NA|NA|NA C radical SAM domain protein MIPOCGNA_01951 322159.STER_0934 2e-155 555.1 Bacilli Z012_04635 Bacteria 1UZI0@1239,4HC2C@91061,COG1396@1,COG1396@2 NA|NA|NA K Transcriptional activator, Rgg GadR MutR family MIPOCGNA_01952 322159.STER_0932 0.0 1176.4 Bacilli lepA ko:K03596 ko05134,map05134 ko00000,ko00001 Bacteria 1TP0G@1239,4HASA@91061,COG0481@1,COG0481@2 NA|NA|NA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner MIPOCGNA_01954 435842.HMPREF0848_00749 1.8e-136 491.9 Bacilli Bacteria 1TRQC@1239,4HD7P@91061,COG1028@1,COG1028@2 NA|NA|NA IQ Acetoin reductase MIPOCGNA_01955 1116231.SMA_1763 2.9e-92 345.1 Bacilli ko:K02030,ko:K16957 ko02010,map02010 M00236,M00585 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.13 Bacteria 1TSTP@1239,4IQKT@91061,COG0834@1,COG0834@2 NA|NA|NA ET Bacterial periplasmic substrate-binding proteins MIPOCGNA_01956 264199.stu0907 4.4e-45 187.2 Bacteria pspE ko:K03972 ko00000 Bacteria COG0607@1,COG0607@2 NA|NA|NA P Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS MIPOCGNA_01957 264199.stu0906 5e-75 287.0 Firmicutes ndk GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 Bacteria 1V44G@1239,COG0105@1,COG0105@2 NA|NA|NA F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate MIPOCGNA_01958 1046629.Ssal_01022 1e-34 152.1 Bacilli XK27_05470 Bacteria 1TPDQ@1239,4HADW@91061,COG0620@1,COG0620@2 NA|NA|NA E Methionine synthase MIPOCGNA_01959 264199.stu0905 1.4e-77 295.4 Bacilli XK27_05470 Bacteria 1TPDQ@1239,4HADW@91061,COG0620@1,COG0620@2 NA|NA|NA E Methionine synthase MIPOCGNA_01960 322159.STER_0927 9.6e-258 895.6 Bacilli trmFO GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 ko:K04094 ko00000,ko01000,ko03016,ko03036 Bacteria 1TP67@1239,4HB27@91061,COG1206@1,COG1206@2 NA|NA|NA J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs MIPOCGNA_01961 264199.stu0902 3.4e-250 870.5 Bacilli Bacteria 1TS1G@1239,4HEWT@91061,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor MIPOCGNA_01962 322159.STER_0925 2.2e-122 444.9 Firmicutes Bacteria 1TQ0D@1239,COG0745@1,COG0745@2 NA|NA|NA KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain MIPOCGNA_01963 322159.STER_0924 3.6e-154 550.8 Bacilli Bacteria 1V2FW@1239,2DC01@1,2ZC51@2,4HG69@91061 NA|NA|NA S TraX protein MIPOCGNA_01964 322159.STER_0923 0.0 1323.9 Bacilli topA 5.99.1.2 ko:K03168 ko00000,ko01000,ko03032,ko03400 Bacteria 1TPUS@1239,4HA6C@91061,COG0550@1,COG0550@2 NA|NA|NA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone MIPOCGNA_01965 264199.stu0896 3.5e-157 560.8 Bacilli dprA GO:0007154,GO:0008150,GO:0009292,GO:0009294,GO:0009605,GO:0009987,GO:0009991,GO:0030420,GO:0031668,GO:0044764,GO:0050896,GO:0051704,GO:0051716,GO:0071496 ko:K04096 ko00000 Bacteria 1TPP7@1239,4HGWM@91061,COG0758@1,COG0758@2 NA|NA|NA LU DNA protecting protein DprA MIPOCGNA_01966 264199.stu0895 3.5e-166 590.9 Firmicutes Bacteria 1TRQ7@1239,COG1940@1,COG1940@2 NA|NA|NA GK ROK family MIPOCGNA_01967 322159.STER_0920 2.6e-135 488.0 Bacilli rnhB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03470 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Bacteria 1V1D6@1239,4HB7M@91061,COG0164@1,COG0164@2 NA|NA|NA L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids MIPOCGNA_01968 264199.stu0893 1.1e-158 565.8 Bacilli ylqF GO:0003674,GO:0003824,GO:0003924,GO:0008150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022613,GO:0042254,GO:0044085,GO:0071840 ko:K14540 ko00000,ko03009 Bacteria 1TQGK@1239,4HA4D@91061,COG1161@1,COG1161@2 NA|NA|NA S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity MIPOCGNA_01969 264199.stu0892 8.1e-128 463.0 Bacilli Bacteria 1V758@1239,4HIKZ@91061,COG1396@1,COG1396@2,COG2932@1,COG2932@2 NA|NA|NA K DNA-binding helix-turn-helix protein MIPOCGNA_01970 264199.stu0891 3e-90 337.8 Bacilli niaR ko:K07105 ko00000 Bacteria 1V6EY@1239,4HGYB@91061,COG1827@1,COG1827@2 NA|NA|NA S small molecule binding protein (contains 3H domain) MIPOCGNA_01971 264199.stu0890 3.1e-87 327.8 Bacilli niaX GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K16788 ko00000,ko02000 2.A.88.5 Bacteria 1V4NF@1239,2A1RE@1,311D4@2,4HH6C@91061 NA|NA|NA MIPOCGNA_01972 264199.stu0889 1.6e-272 944.9 Bacilli ffh GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 Bacteria 1TP06@1239,4H9T4@91061,COG0541@1,COG0541@2 NA|NA|NA U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY MIPOCGNA_01973 264199.stu0888 1.1e-53 215.7 Bacilli ylxM GO:0003674,GO:0008150,GO:0030234,GO:0030695,GO:0050790,GO:0060589,GO:0065007,GO:0065009,GO:0098772 ko:K09787 ko00000 Bacteria 1VEGP@1239,4HKK6@91061,COG2739@1,COG2739@2 NA|NA|NA S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein MIPOCGNA_01974 322159.STER_0913 2e-126 458.4 Bacilli gntR1 ko:K03710,ko:K11922 ko00000,ko03000 Bacteria 1UYBW@1239,4HDDG@91061,COG2188@1,COG2188@2 NA|NA|NA K transcriptional MIPOCGNA_01975 264199.stu0886 4.3e-302 1043.1 Bacilli guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.3.1.128,6.3.5.2 ko:K01951,ko:K03790 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002,ko03009 iJN746.PP_1032,iLJ478.TM1820,iSF_1195.SF2553,iSFxv_1172.SFxv_2808,iS_1188.S2725,iYL1228.KPN_02833 Bacteria 1TPG8@1239,4HA7Q@91061,COG0518@1,COG0518@2,COG0519@1,COG0519@2 NA|NA|NA F Catalyzes the synthesis of GMP from XMP MIPOCGNA_01976 264199.stu0885 0.0 1274.2 Bacilli sthIM 2.1.1.72 ko:K07316 ko00000,ko01000,ko02048 Bacteria 1TR8A@1239,4HBP1@91061,COG2189@1,COG2189@2 NA|NA|NA L Adenine specific DNA methylase Mod MIPOCGNA_01977 264199.stu0884 0.0 1801.2 Bacilli res_1 3.1.21.5 ko:K01156 ko00000,ko01000,ko02048 Bacteria 1TRVK@1239,4HAVG@91061,COG3421@1,COG3421@2 NA|NA|NA S Type III restriction MIPOCGNA_01978 1116231.SMA_0980 3e-21 107.1 Bacilli Bacteria 1W1ET@1239,2DY2G@1,347TK@2,4HYVW@91061 NA|NA|NA MIPOCGNA_01980 904306.HMPREF9192_1827 5.7e-110 403.7 Bacilli adhP GO:0003674,GO:0003824,GO:0004022,GO:0005488,GO:0006081,GO:0006117,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009636,GO:0009987,GO:0010033,GO:0016491,GO:0016614,GO:0016616,GO:0033554,GO:0042221,GO:0042493,GO:0043167,GO:0043169,GO:0044237,GO:0044248,GO:0045471,GO:0046185,GO:0046187,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0097305,GO:1901575,GO:1901700 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 iECP_1309.ECP_1480 Bacteria 1TP5B@1239,4HA9Z@91061,COG1064@1,COG1064@2 NA|NA|NA C alcohol dehydrogenase MIPOCGNA_01981 264199.stu0880 5.6e-61 240.0 Bacilli adhP GO:0003674,GO:0003824,GO:0004022,GO:0005488,GO:0006081,GO:0006117,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009636,GO:0009987,GO:0010033,GO:0016491,GO:0016614,GO:0016616,GO:0033554,GO:0042221,GO:0042493,GO:0043167,GO:0043169,GO:0044237,GO:0044248,GO:0045471,GO:0046185,GO:0046187,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0097305,GO:1901575,GO:1901700 1.1.1.1 ko:K00001,ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 iECP_1309.ECP_1480 Bacteria 1TP5B@1239,4HA9Z@91061,COG1064@1,COG1064@2 NA|NA|NA C alcohol dehydrogenase MIPOCGNA_01982 435842.HMPREF0848_00769 2.1e-07 60.1 Firmicutes Bacteria 1VFJD@1239,2E660@1,330UP@2 NA|NA|NA MIPOCGNA_01983 264199.stu0879 1.6e-65 255.4 Bacilli uvrX 2.7.7.7 ko:K02346,ko:K03502,ko:K14161 ko00000,ko01000,ko03400 Bacteria 1TP42@1239,4HA1P@91061,COG0389@1,COG0389@2 NA|NA|NA L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII MIPOCGNA_01984 264199.stu0879 1.1e-31 142.1 Bacilli uvrX 2.7.7.7 ko:K02346,ko:K03502,ko:K14161 ko00000,ko01000,ko03400 Bacteria 1TP42@1239,4HA1P@91061,COG0389@1,COG0389@2 NA|NA|NA L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII MIPOCGNA_01985 904306.HMPREF9192_1830 2.1e-73 281.6 Bacilli uvrX 2.7.7.7 ko:K02346,ko:K03502,ko:K14161 ko00000,ko01000,ko03400 Bacteria 1TP42@1239,4HA1P@91061,COG0389@1,COG0389@2 NA|NA|NA L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII MIPOCGNA_01986 322159.STER_0907 1.2e-157 562.4 Firmicutes aatB ko:K02029,ko:K02030 M00236 ko00000,ko00002,ko02000 3.A.1.3 Bacteria 1TQNR@1239,COG0834@1,COG0834@2 NA|NA|NA ET ABC transporter substrate-binding protein MIPOCGNA_01987 264199.stu0876 1.5e-112 412.1 Bacteria glnQ 3.6.3.21 ko:K02028 M00236 ko00000,ko00002,ko01000,ko02000 3.A.1.3 Bacteria COG1126@1,COG1126@2 NA|NA|NA E abc transporter atp-binding protein MIPOCGNA_01988 264199.stu0875 5.3e-105 387.1 Bacilli artQ ko:K02029,ko:K02030,ko:K17073,ko:K17074 ko02010,map02010 M00236,M00589 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.20 Bacteria 1V280@1239,4HGMH@91061,COG0765@1,COG0765@2 NA|NA|NA P ABC transporter (Permease MIPOCGNA_01989 322159.STER_0904 6.1e-57 226.5 Bacilli phnA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K06193 ko01120,map01120 ko00000 Bacteria 1V6NA@1239,4HIKN@91061,COG2824@1,COG2824@2 NA|NA|NA P Alkylphosphonate utilization operon protein PhnA MIPOCGNA_01990 322159.STER_0903 0.0 1164.8 Bacilli glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 iNJ661.Rv3436c,iSB619.SA_RS11245,iYO844.BSU01780 Bacteria 1TPGU@1239,4H9R4@91061,COG0449@1,COG0449@2 NA|NA|NA M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source MIPOCGNA_01991 322159.STER_0901 2.2e-165 588.2 Bacilli cpsY Bacteria 1TP3E@1239,4HC5J@91061,COG0583@1,COG0583@2 NA|NA|NA K Transcriptional regulator MIPOCGNA_01992 264199.stu1454 4.2e-20 103.6 Bacteria ko:K07483 ko00000 Bacteria COG2963@1,COG2963@2 NA|NA|NA L transposase activity MIPOCGNA_01993 904306.HMPREF9192_1840 1.6e-118 432.2 Bacilli mur1 ko:K02395 ko00000,ko02035 Bacteria 1UYRM@1239,4HAU6@91061,COG1705@1,COG1705@2 NA|NA|NA NU muramidase MIPOCGNA_01994 322159.STER_0898 1.5e-170 605.5 Firmicutes yeiH Bacteria 1TQYA@1239,COG2855@1,COG2855@2 NA|NA|NA S Membrane MIPOCGNA_01995 663952.SDD27957_05960 1.7e-08 65.9 Streptococcus dysgalactiae group Bacteria 1M9M6@119603,1TXBA@1239,2DJ70@1,304WJ@2,4I68X@91061 NA|NA|NA MIPOCGNA_01996 264199.stu0860 6.2e-293 1012.7 Bacilli adcA GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0007154,GO:0008150,GO:0008270,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010035,GO:0010038,GO:0030288,GO:0030313,GO:0031667,GO:0031668,GO:0031669,GO:0031975,GO:0033554,GO:0034224,GO:0042221,GO:0042594,GO:0042597,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046686,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0120127 ko:K09815 ko02010,map02010 M00242 ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 Bacteria 1TPG7@1239,4H9UN@91061,COG0803@1,COG0803@2,COG3443@1,COG3443@2 NA|NA|NA P Belongs to the bacterial solute-binding protein 9 family MIPOCGNA_01997 264199.stu0859 6.4e-58 229.9 Bacteria XK27_10720 Bacteria COG2339@1,COG2339@2 NA|NA|NA D peptidase activity MIPOCGNA_01998 1046629.Ssal_00974 2.4e-57 228.0 Bacilli pepD ko:K08659 ko00000,ko01000,ko01002 Bacteria 1TQ0F@1239,4HC3G@91061,COG4690@1,COG4690@2 NA|NA|NA E Dipeptidase MIPOCGNA_02000 1449337.JQLL01000001_gene1095 8e-102 377.1 Bacilli Bacteria 1TRZQ@1239,2DB8S@1,2Z7SU@2,4HTXH@91061 NA|NA|NA MIPOCGNA_02001 1215915.BN193_11475 5.6e-101 373.6 Lactococcus ko:K04763 ko00000,ko03036 Bacteria 1UD2A@1239,1YC8P@1357,4IEJF@91061,COG0582@1,COG0582@2 NA|NA|NA L Phage integrase family MIPOCGNA_02002 1215915.BN193_11480 1.5e-147 528.9 Lactococcus Bacteria 1U2J5@1239,1YC8Q@1357,2BJ8M@1,32DI8@2,4IC6N@91061 NA|NA|NA MIPOCGNA_02003 264199.stu0851 7.4e-55 219.5 Bacteria hsdS 2.1.1.72,3.1.21.3 ko:K01154,ko:K07317 ko00000,ko01000,ko02048 Bacteria COG0732@1,COG0732@2 NA|NA|NA V type I restriction modification DNA specificity domain MIPOCGNA_02004 264199.stu0852 7.7e-94 349.7 Bacilli hsdM 2.1.1.72 ko:K03427 ko00000,ko01000,ko02048 Bacteria 1TPGZ@1239,4HA1J@91061,COG0286@1,COG0286@2 NA|NA|NA V type I restriction-modification system MIPOCGNA_02005 322159.STER_0891 1.5e-150 538.9 Bacilli glcU ko:K05340 ko00000,ko02000 2.A.7.5 Bacteria 1TQBN@1239,4HAVH@91061,COG4975@1,COG4975@2 NA|NA|NA U Glucose uptake MIPOCGNA_02006 322159.STER_0015 5.6e-161 573.5 Firmicutes ko:K07485 ko00000 Bacteria 1TQ93@1239,COG3464@1,COG3464@2 NA|NA|NA L Transposase MIPOCGNA_02007 322159.STER_0014 0.0 1253.0 Bacilli ftsH GO:0003674,GO:0003824,GO:0004176,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0030428,GO:0032502,GO:0042623,GO:0043170,GO:0043934,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 ko:K03798 M00742 ko00000,ko00002,ko01000,ko01002,ko03110 Bacteria 1TPTV@1239,4HAJB@91061,COG0465@1,COG0465@2 NA|NA|NA O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins MIPOCGNA_02008 264199.stu0011 3.4e-97 360.9 Bacilli hpt GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.2.8,6.3.4.19 ko:K00760,ko:K15780 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000,ko03016 Bacteria 1V1C9@1239,4HFZ2@91061,COG0634@1,COG0634@2 NA|NA|NA F Belongs to the purine pyrimidine phosphoribosyltransferase family MIPOCGNA_02009 264199.stu0010 5.5e-239 833.2 Bacilli tilS 2.4.2.8,6.3.4.19 ko:K04075,ko:K15780 ko00230,ko01100,ko01110,map00230,map01100,map01110 R01132,R01229,R02142,R09597 RC00063,RC00122,RC02633,RC02634 ko00000,ko00001,ko01000,ko03016 Bacteria 1TPXP@1239,4H9ZM@91061,COG0037@1,COG0037@2 NA|NA|NA D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine MIPOCGNA_02010 322159.STER_0011 1.5e-239 835.1 Bacilli XK27_09285 3.5.2.6 ko:K01467,ko:K17836 ko00311,ko01130,ko01501,ko02020,map00311,map01130,map01501,map02020 M00627,M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000,ko01504 Bacteria 1VGXR@1239,4IPWW@91061,COG2367@1,COG2367@2 NA|NA|NA V Beta-lactamase enzyme family MIPOCGNA_02012 322159.STER_0009 7.9e-61 239.6 Bacilli divIC ko:K05589,ko:K13052 ko00000,ko03036 Bacteria 1VKC5@1239,4HR53@91061,COG2919@1,COG2919@2 NA|NA|NA D Septum formation initiator MIPOCGNA_02013 264199.stu0007 1.7e-39 168.3 Bacilli yabO GO:0008150,GO:0040007 Bacteria 1VEI5@1239,4HKJJ@91061,COG1188@1,COG1188@2 NA|NA|NA J Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) MIPOCGNA_02014 322159.STER_0007 0.0 2258.4 Bacilli mfd ko:K03723 ko03420,map03420 ko00000,ko00001,ko01000,ko03400 Bacteria 1TPF1@1239,4H9NB@91061,COG1197@1,COG1197@2 NA|NA|NA L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site MIPOCGNA_02015 264199.stu0005 1.4e-104 385.6 Bacilli pth GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016788,GO:0040007,GO:0044464,GO:0052689,GO:0071944,GO:0140098,GO:0140101 3.1.1.29 ko:K01056 ko00000,ko01000,ko03012 Bacteria 1V3NB@1239,4HH2Z@91061,COG0193@1,COG0193@2 NA|NA|NA J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis MIPOCGNA_02016 264199.stu0004 8.6e-204 716.1 Bacilli ychF GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0043021,GO:0043022,GO:0043023,GO:0043086,GO:0044092,GO:0044424,GO:0044464,GO:0044877,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0098772 ko:K06942 ko00000,ko03009 Bacteria 1TPRK@1239,4H9SQ@91061,COG0012@1,COG0012@2 NA|NA|NA J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner MIPOCGNA_02017 1046629.Ssal_02164 4.1e-29 133.3 Bacilli yyzM Bacteria 1VEQ7@1239,4HNHU@91061,COG4481@1,COG4481@2 NA|NA|NA S Protein conserved in bacteria MIPOCGNA_02018 322159.STER_0002 2.4e-201 708.0 Bacilli dnaN 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 1TQ7J@1239,4H9TF@91061,COG0592@1,COG0592@2 NA|NA|NA L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria MIPOCGNA_02019 264199.stu0001 4.8e-257 893.3 Bacilli dnaA GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 ko:K02313 ko02020,ko04112,map02020,map04112 ko00000,ko00001,ko03032,ko03036 Bacteria 1TPV7@1239,4H9MW@91061,COG0593@1,COG0593@2 NA|NA|NA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids MIPOCGNA_02020 322159.STER_2003 1e-134 486.1 Bacilli parB ko:K03497 ko00000,ko03000,ko03036,ko04812 Bacteria 1TQ2B@1239,4H9TB@91061,COG1475@1,COG1475@2 NA|NA|NA K Belongs to the ParB family MIPOCGNA_02021 264199.stu2024 1.1e-196 692.6 Bacilli htrA GO:0008150,GO:0009266,GO:0009628,GO:0050896 3.4.21.107 ko:K04691,ko:K04771 ko01503,ko02020,map01503,map02020 M00728 ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 Bacteria 1TRM8@1239,4HA31@91061,COG0265@1,COG0265@2 NA|NA|NA O Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain' MIPOCGNA_02022 322159.STER_2001 2.5e-86 324.7 Bacilli rlmH 2.1.1.177 ko:K00783 ko00000,ko01000,ko03009 Bacteria 1V3JM@1239,4HFP8@91061,COG1576@1,COG1576@2 NA|NA|NA J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA MIPOCGNA_02023 264199.stu2022 1.4e-119 435.6 Firmicutes yoaK Bacteria 1V1VQ@1239,COG3619@1,COG3619@2 NA|NA|NA S Psort location CytoplasmicMembrane, score MIPOCGNA_02027 264199.stu2021 0.0 1662.5 Bacilli XK27_10405 Bacteria 1TRR1@1239,4HCR9@91061,COG4485@1,COG4485@2 NA|NA|NA S Bacterial membrane protein YfhO MIPOCGNA_02028 264199.stu2020 6.7e-306 1055.8 Bacilli ybiT GO:0006950,GO:0008150,GO:0009266,GO:0009409,GO:0009628,GO:0050896 ko:K06158 ko00000,ko03012 Bacteria 1TPW0@1239,4HATH@91061,COG0488@1,COG0488@2 NA|NA|NA S abc transporter atp-binding protein MIPOCGNA_02029 322159.STER_1994 5.4e-153 547.0 Bacilli yvjA Bacteria 1TR9J@1239,4H9N6@91061,COG1284@1,COG1284@2 NA|NA|NA S membrane MIPOCGNA_02030 264199.stu2018 1.4e-192 678.7 Bacilli trpS GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1TPY7@1239,4HA1K@91061,COG0180@1,COG0180@2 NA|NA|NA J Tryptophanyl-tRNA synthetase MIPOCGNA_02031 322159.STER_1992 4.7e-274 949.9 Bacilli guaB GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 iAPECO1_1312.APECO1_4018,iECABU_c1320.ECABU_c28100,iECP_1309.ECP_2510,iECSF_1327.ECSF_2349,iUTI89_1310.UTI89_C2826,ic_1306.c3027 Bacteria 1TNZ1@1239,4H9V3@91061,COG0516@1,COG0516@2,COG0517@1,COG0517@2 NA|NA|NA F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth MIPOCGNA_02032 322159.STER_1991 2.5e-203 714.5 Bacilli recF GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 ko:K03629 ko03440,map03440 ko00000,ko00001,ko03400 Bacteria 1TP9U@1239,4HA0W@91061,COG1195@1,COG1195@2 NA|NA|NA L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP MIPOCGNA_02033 264199.stu2014 3.6e-45 187.6 Bacilli yaaA GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K14761 ko00000,ko03009 Bacteria 1VKF4@1239,4HRX5@91061,COG2501@1,COG2501@2 NA|NA|NA S S4 domain protein YaaA MIPOCGNA_02034 322159.STER_1989 1.5e-233 815.1 Bacilli ymfF Bacteria 1TPN6@1239,4H9P5@91061,COG0612@1,COG0612@2 NA|NA|NA S Peptidase M16 MIPOCGNA_02035 264199.stu2012 7.4e-228 796.2 Bacilli ymfH ko:K07263 ko00000,ko01000,ko01002 Bacteria 1TP5I@1239,4H9YG@91061,COG0612@1,COG0612@2 NA|NA|NA S Peptidase M16 MIPOCGNA_02036 322159.STER_1987 7e-137 493.4 Bacteria ymfM ko:K15539 ko00000 Bacteria COG1426@1,COG1426@2 NA|NA|NA S sequence-specific DNA binding MIPOCGNA_02037 264199.stu2010 4.1e-90 337.4 Bacilli pgsA GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 iSB619.SA_RS06365 Bacteria 1V6PJ@1239,4HCEX@91061,COG0558@1,COG0558@2 NA|NA|NA I Belongs to the CDP-alcohol phosphatidyltransferase class-I family MIPOCGNA_02038 322159.STER_1985 1.8e-150 538.5 Bacilli ecfA1 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015238,GO:0015711,GO:0015893,GO:0016020,GO:0022857,GO:0032217,GO:0032218,GO:0034220,GO:0035461,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051180,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0090482,GO:0098656 ko:K16784,ko:K16786,ko:K16787 ko02010,map02010 M00581,M00582 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 Bacteria 1TPH8@1239,4H9R8@91061,COG1122@1,COG1122@2 NA|NA|NA P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates MIPOCGNA_02039 264199.stu2008 3.8e-151 540.8 Bacilli ecfA2 GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0008144,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015238,GO:0015711,GO:0015893,GO:0016020,GO:0017076,GO:0022857,GO:0030554,GO:0032217,GO:0032218,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035461,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0044464,GO:0050896,GO:0051179,GO:0051180,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0090482,GO:0097159,GO:0097367,GO:0098656,GO:1901265,GO:1901363 3.6.3.55 ko:K02068,ko:K06857,ko:K16784,ko:K16786,ko:K16787 ko02010,map02010 M00186,M00211,M00581,M00582 R10531 RC00002 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35,3.A.1.6.2,3.A.1.6.4 Bacteria 1TPH8@1239,4HA7T@91061,COG1122@1,COG1122@2 NA|NA|NA P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates MIPOCGNA_02040 264199.stu2007 1e-134 486.1 Bacilli ecfT GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015238,GO:0015711,GO:0015893,GO:0016020,GO:0022857,GO:0032217,GO:0032218,GO:0034220,GO:0035461,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051180,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0090482,GO:0098656 ko:K02008,ko:K16783,ko:K16785 ko02010,map02010 M00245,M00246,M00581,M00582 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23,3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 Bacteria 1TQ0E@1239,4H9VT@91061,COG0619@1,COG0619@2 NA|NA|NA P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates MIPOCGNA_02041 264199.stu2006 3.9e-80 304.3 Bacilli lytE Bacteria 1VA10@1239,4HMUH@91061,COG1388@1,COG1388@2 NA|NA|NA M LysM domain protein MIPOCGNA_02042 322159.STER_1981 8.2e-44 183.7 Bacilli isaA ko:K21687 ko00000 GH23 Bacteria 1VGPA@1239,4HP1I@91061,COG0741@1,COG0741@2 NA|NA|NA M Immunodominant staphylococcal antigen A MIPOCGNA_02043 322159.STER_1980 6.8e-301 1039.3 Bacilli Bacteria 1V0XZ@1239,4HEBN@91061,COG4485@1,COG4485@2 NA|NA|NA S Bacterial membrane protein, YfhO MIPOCGNA_02044 1046629.Ssal_00023 2.4e-214 751.1 Bacilli mnmA GO:0001510,GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0003824,GO:0004808,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016782,GO:0016783,GO:0030488,GO:0032259,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.8.1.13 ko:K00566 ko04122,map04122 R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 Bacteria 1TPIZ@1239,4HBJ6@91061,COG0482@1,COG0482@2 NA|NA|NA J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 MIPOCGNA_02045 435842.HMPREF0848_01708 2e-74 285.0 Bacilli Bacteria 1VAVP@1239,4HSPC@91061,COG1051@1,COG1051@2 NA|NA|NA F NUDIX domain MIPOCGNA_02046 435842.HMPREF0848_01709 0.0 1227.2 Bacilli gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 ko:K03495 R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 Bacteria 1TQ4B@1239,4HA6S@91061,COG0445@1,COG0445@2 NA|NA|NA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 MIPOCGNA_02047 322159.STER_1977 0.0 1255.0 Bacilli yybT Bacteria 1TPGP@1239,4HBVH@91061,COG3887@1,COG3887@2 NA|NA|NA T signaling protein consisting of a modified GGDEF domain and a DHH domain MIPOCGNA_02048 435842.HMPREF0848_01711 8.5e-73 279.6 Bacilli rplI GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02939 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V6QG@1239,4HIKJ@91061,COG0359@1,COG0359@2 NA|NA|NA J binds to the 23S rRNA MIPOCGNA_02049 322159.STER_1975 1.5e-245 855.1 Bacilli dnaB GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 ko00000,ko00001,ko01000,ko03032 Bacteria 1TPCT@1239,4H9Y8@91061,COG0305@1,COG0305@2 NA|NA|NA L Participates in initiation and elongation during chromosome replication MIPOCGNA_02050 264199.stu1998 8.2e-48 196.1 Bacilli veg Bacteria 1VPZY@1239,4HSFF@91061,COG4466@1,COG4466@2 NA|NA|NA S Biofilm formation stimulator VEG MIPOCGNA_02051 264199.stu1997 4.9e-108 397.1 Bacilli rpsD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 ko:K02986 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1TR0J@1239,4HAC9@91061,COG0522@1,COG0522@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit MIPOCGNA_02052 1123318.KB904633_gene1270 2e-07 61.2 Bacilli Bacteria 1W3FT@1239,2914P@1,2ZNS1@2,4I23Q@91061 NA|NA|NA MIPOCGNA_02053 1046629.Ssal_00032 5.5e-11 72.4 Firmicutes ypaA ko:K08987 ko00000 Bacteria 1VAEU@1239,COG3759@1,COG3759@2 NA|NA|NA M Membrane MIPOCGNA_02054 264199.stu1995 2.1e-94 351.7 Bacteria XK27_06935 Bacteria COG1309@1,COG1309@2 NA|NA|NA K transcriptional regulator MIPOCGNA_02055 322159.STER_1969 4e-158 565.5 Bacilli XK27_06930 ko:K01421 ko00000 Bacteria 1TQ15@1239,4H9T9@91061,COG1511@1,COG1511@2 NA|NA|NA V domain protein MIPOCGNA_02056 264199.stu1992 3.1e-108 398.3 Bacilli Bacteria 1VGGF@1239,4I0VY@91061,COG3595@1,COG3595@2 NA|NA|NA S Putative adhesin MIPOCGNA_02057 904306.HMPREF9192_1905 9.1e-13 79.3 Bacilli XK27_06920 Bacteria 1VBG6@1239,4HSRQ@91061,COG4709@1,COG4709@2 NA|NA|NA S Protein of unknown function (DUF1700) MIPOCGNA_02058 435842.HMPREF0848_01720 9.6e-08 61.2 Bacilli XK27_06920 Bacteria 1VBG6@1239,4HSRQ@91061,COG4709@1,COG4709@2 NA|NA|NA S Protein of unknown function (DUF1700) MIPOCGNA_02059 435842.HMPREF0848_01721 3e-48 197.6 Bacilli ko:K10947 ko00000,ko03000 Bacteria 1VIVQ@1239,4IR4R@91061,COG1695@1,COG1695@2 NA|NA|NA K transcriptional regulator, PadR family # 1866 queries scanned # Total time (seconds): 4.92628598213 # Rate: 378.78 q/s