LOCUS       c00100_JAAFGQ0..       15504 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAAFGQ010000006.1 Lacticaseibacillus paracasei strain D10-4
            NODE_6_length_93130_cov_197.442, whole genome shotgun sequence.
ACCESSION   JAAFGQ010000006
VERSION     JAAFGQ010000006
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2022-06-21 00:21:45
            Original ID  :: JAAFGQ010000006.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15504
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15504
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2241:5504]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2242..5504
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..15504
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15504
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             complement(206..1138)
                     /locus_tag="ctg100_1"
                     /transl_table=11
                     /translation="MTTLIFGHQNPDTDAITSAMSWAEFQKQAGNTDVEAVALGEPNDE
                     TKFVLDHFKVQAPRVIKTAANETDHVMLVDHNEFQQSVSDIEDVTIDSVVDHHRIANFH
                     TAAPLFYRAEPVGSTNTVIFEMFQEYGFKISPTLAGLMASGLISDTLLLKSPTATDKDK
                     KILPEMAKIAGIDLQSYGLAMLKAGTNLAAKSDMDIIEGDAKSFTMGGKSIRIGQVNTV
                     DLNDIYARQDELINAMTKEAQAKGYDDFLLIATDILDSNSTGFAVGADRDKIASAFNEQ
                     FDKDARLALPGVVSRKKQVVPPMQSTFEG"
     CDS             complement(1168..2136)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     60.8; E-value: 3.2e-19)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg100_2"
                     /sec_met_domain="LysR_substrate (E-value: 1.2e-26,
                     bitscore: 85.7, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 4.2e-19, bitscore: 60.8,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTKQERIFSSKTLTYFLQLAETMNYTQAAQLLGITQPALTQQIK
                     KLERTVGAPLFYSVGKKLHLSDAGQTMLKSTHEIYEILNQTTDEIQQTTSATVGKINIG
                     LLSSIEDSAFIAFIAHYYQLNPEVEVTLRMMTRHEIWESLENNQIDLAIMNLPDETIKN
                     WKPYASKKIIDEQLLFLHHDDALANRKRIHFKDTLAEPWATYPDDYFLGQLLREAYKNQ
                     MVDFPHVVAHFTTPYQLTQFVNLSGVNTALPTSFVRARADQIKAYAIAFDPAIRFEISF
                     VYRKEKADIPRISNFFQTFDDYLKEKDYLSRVSENRVKLDK"
     CDS             complement(2242..3111)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 65.2;
                     E-value: 2.5e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg100_3"
                     /sec_met_domain="Radical_SAM (E-value: 2.3e-25, bitscore:
                     82.3, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLIDQSQSPLNILEQVGQDHDGPIKGYVHSVESFGSVDGPGIRF
                     VVFMQGCRMRCQYCHNPDTWNIGVGEEMTADQILADAQRYKAFWGDQGGITCSGGESLV
                     QIDFILELFTKAKALGISTCLDTSGGPFTRDQPWFGQFEKLMAVTDISLVDIKHIDSAE
                     HKKLTGFPNENILDMVQYMSAHGDDMWIRHVLVPERTDFDPYLKRLGDYIATLDKNVVQ
                     KVEILPYHTLGLKSITSLALRTRLKASNRRLPIALRMQRICCTLRIIPDGKAGVRNQLR
                     ATEFLART"
     CDS             complement(3243..5504)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg100_4"
                     /sec_met_domain="Gly_radical (E-value: 3.3e-41, bitscore:
                     132.6, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate2 (E-value: 1.4e-243, bitscore:
                     802.0, seeds: 33, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQLDETKVPNYWEGFNGGDWQEEINVRDFIEHNLNQYDGDESFL
                     AGPTEATTVLNNQVLNLKKQERANGGVLDADNNIPSTITSHGPGYLNKDLEKIVGVQTD
                     KPFKRAFMPFGGIRMAEDALESYGFKTDPQEHKIFNEYRKTHNQGVFDAYTPDMRKARH
                     YKIVTGLPDAYGRGRIVSDFPRIAVYGIDRLMAEKFKDYNLTGDGEMTDDVIKLREEIN
                     EQYRALNDMKKMAKEYGYDISRPAANAQEAVQWIYFGYLAAVKTQNGAAMSVGRIDTVI
                     DAYIQRDMRLGKLNEEQAQELIDHLVMKLRMVRFIRTEEYNSLFSGDPIWATLSLAGMG
                     NDGRHHVTKTAFRFLKTLDNMGAAPEPNITLLWSERLPEGFKRYATEVSIQSSTIQYEN
                     DDLMRNEWGTDYYGIACCVSAQPIADGVQYFGARANLAKTVLYAINGGKDEIQEAQVGP
                     EYAPITSDYIDYKEFMNKFDKMMDWLADTYVNALNVIHYMHDKYYYEAAQLALKDTQLN
                     RTFATGISGLSHAVDSISAIKYGHVKAIRDENGVAVDFVADNDDYPRYGNNDDRADDIA
                     KWLVKTFYNKMNTHHLYRGAKLSTSVLTITSNVVYGKNTGTTPNGRQKGEPFSPGANPA
                     YGAEKNGALASLMSTAKIPYHYATDGISNTFGVTPNTLGHDDETRKDTLVHMVDGYMEN
                     SGMHLNINVFNKETLIDAQKHPEEYPTLTVRVSGYCVYFADLTKEQQDDVIARTFFEEM
                     "
     CDS             complement(5756..8200)
                     /locus_tag="ctg100_5"
                     /transl_table=11
                     /translation="LANQIQELTLEEVMGDRFGRYSKYIIQERALPDVRDGLKPVQRRI
                     LFAMNQDGNTYDKGFRKSAKSVGNVMGNYHPHGDSSIYEAMVRLSQDWKLRAPLIQMHG
                     NNGSMDGDPPAAMRYTEARLSKISKEMLADIDKETVDMVLNFDDTAQEPTVLPAGFPNL
                     LVNGATGISAGYATEIPPHNLREVIAAVLYLLKHPTADLDTLMQYVKGPDFPTGGIIQG
                     LDGIKQAYETGRGKIVVRSRTHIETIRGGREKIVVTEIPYDVNKAQMIKKIDELRINKK
                     VDGIAEVRDESDRFGLSVVIELKKEADAHGILNYLFKNTDLQIAYNFNMVAIADMQPKL
                     LGLKAMLEAYVEHRRDVVTRRTRFDLNKAAARQHIVEGLIKMLSILDQVIAAIRASKDK
                     GDAKRNLVKKFDFSEAQAEAIVSLQLYRLTNTDITALQKEAAQLAKAIAEYQDILARPA
                     ARDRVIEGELKRIAKEYGDDRRSSIQAKIETLEVATTVTVADETVMVQVSRDGYVKRSS
                     LRSYQAVDPADNGLKANDLAIFTGELSTLQHLYIVTNAGNVIYRPVHEISDARWKDTGE
                     HLSQTVGLGTDEKVLAVFAFDQLDGAGSFVLGSSDGYIKQTALSDLQPQRTYKSKPMMA
                     MKLKDPAAIVTNAYFTTDQQQDVFVVSRHAYGLTFPLSDVSTVGARATGVKSMDLKPDD
                     EVVNFILVKDPTTAKVGILTQRGAFKKMALSEVGEMSRARRGLLVLRELKRDPHRIVAM
                     MSVDDATRLNVLTDTGKVTTLNPAQHPAGDRYSNGSFVIDTDVLGKPVFVQTKEEPADQ
                     VE"
     CDS             complement(8207..10219)
                     /locus_tag="ctg100_6"
                     /transl_table=11
                     /translation="MDKATQAYNDSSIQVLHGLEAVRKRPGMYIGSTDGRGLHHLVYEI
                     VDNSVDEALAGFGDEINVTIHADNSVTVQDHGRGMPTGMHPSGKPTIEVILTVLHAGGK
                     FNQNSYKTSGGLHGVGSSVVNALSESLTVRVVRDKHAFEEHFINGGHPDGSLQKLGKVN
                     EPNGTTITFKPDPTIFQTTVFSYDTLAERLRESAFLLKNITINLTDERTGKHDSYHYPD
                     GLVSFVKYLNEGKDALSQVINFEGKKDGIVVDFAGQYNDGYSENLISFVNNVRTGDGGT
                     HEIGLRSGMTRAFNEFARKVGLLRERDKNLEGSDVREGFAGILSVRIPEEILQFEGQTK
                     GKLGTPQARTVVDGIVYDKLSTFLMENGEESQELVRKAVKARDAREAARKARDDSRTGR
                     KRKKDQGLLSGKLTPAQTKNPKRNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVLNT
                     QKAKLQDIVKNEEINTMIYTIGAGVGADFDLQQANYDKIIIMTDADTDGAHIQILLLTF
                     FYRYMRPLIDAGRIYIALPPLYRLQKGAGAKTKISYAWTDEELAKETKAMGKGYTLTRF
                     KGLGEMNADQLWETTMNPETRTLIRVRIDDAQLAERRVTTLMGDRVEPRREWIEHNVKF
                     DMDDDGSILETPTANHEKLQFGAKQIVKQLDKKGK"
     CDS             10936..11643
                     /locus_tag="ctg100_7"
                     /transl_table=11
                     /translation="MYVRFILLTYHSKVKNAKIVSSLRGGAHLILVLCFILAYFIGAIP
                     FGVVIGKLFYHTDIRKGGSHNIGTTNAYRMLGPVGGSIVLVLDILKGTLAASLPILFGI
                     EHHWLVLIVGLAAVFGHTFSIYIRFKGGKAVATSAGILLAYNPPFFVIAFAIWFSLILL
                     TSMVSVASTLGMVLITAWSLVYHDWLLTTVACGLLVVFLIKHRANFKRIKAGDENMVPF
                     GLGQYLRQHRGRS"
     CDS             complement(11725..12603)
                     /locus_tag="ctg100_8"
                     /transl_table=11
                     /translation="MVTIANDFLTVKISRHGAELTSIKDNLTGRERLWQADPAVWGRHA
                     PVLFPIVGALADNQYHYAGKTYHMGQHGFARDRDFTVLSATPFKASFVLKDDDKTRAMY
                     PFAFRLIITFALENNNLHVTYHVDNPDKSEPLFFSIGGHPGFKVPMTPDTQFSDYYLNF
                     KPRKSLVQIPLVAGEGIDYTHRTLAATDANLALTHETFDHDALIFALLGKTTFNLVSDK
                     TKHGVSVTMTDTPYLGVWSPYPTTGDFVCIEPWWGIADTIGSTGDLTRKLGINRLEPGT
                     AFEKGYMISIF"
     CDS             complement(12639..14048)
                     /locus_tag="ctg100_9"
                     /transl_table=11
                     /translation="MAEVQTPKQIVEKLDQYVIGQDDAKRAVAVALYNRYRRMQLSPKM
                     QEEITPKNLLMIGPTGVGKTEIARRLAKIVEAPFVKVEATKFTEVGYVGRDVESMVRDL
                     AETAVAMEEEKQFSKVRIRAEKEANKRLVKILVPAIRKEKNTNPMAEMMSMLQGMQNGK
                     MPAGDDADAGGEVTDDIRNKRLSVAEQLEKGLLEDHEITVAVNDEKKGGGMGDMYGQMG
                     IDLSDTIGALMPKKKVERTMTVKEAREIFIKEESDKLVNHADIYHDAIQSAENNGIIFI
                     DEIDKIAAGNKHNSGEVSREGVQRDILPIVEGSQINTKYGPINTDHILFIGSGAFAEAK
                     PSDLIAELQGRFPIRVELKDLTEKDFVRILTEPDNALIKQYIALIGADGVKITFTKEAV
                     DRIAEIATQVNHDTDNIGARRLATILEKLLEDVLYEGPDMAMGSVTVTQQYVDDKIGHI
                     AADSNMTRYIL"
     CDS             complement(14092..14616)
                     /locus_tag="ctg100_10"
                     /transl_table=11
                     /translation="MTTIAAVRKDGVTALAGDGQVTLGEKVIMKGNAQKVRRIYHDQVV
                     IGFAGGVADAFTLQDWFEKKLEHYAGNLRRSAVALAQDWRKDPTLQKLEAMMIVMDEHD
                     LLLVSGSGEVIDPDEDVVAIGSGGNFAQAAAIAMLRHAPDMTPADIAKEAVNIAGNIDI
                     FTNHNVIVESF"
ORIGIN
        1 tcctccaatc ttcttgatag accaagtata gagggaggat tttgacaatt ataggtactg
       61 cactatgtga cgcttacgtt gctagtcagc tttatattta acagatttcg caaaaagatg
      121 gctagagact ttttgcaaac aaaaaagccg caactggcta gctgcgactt tccttagaac
      181 aattgtgtgc aattaaagat gaaagttaac cttcaaacgt gctctgcatt ggcggaacga
      241 cctgcttttt gcgggaaaca accccaggca atgccaaacg cgcgtccttg tcgaactgtt
      301 cgttaaaagc actggcgatt ttatcgcggt cagcaccgac tgcgaaacca gttgaattgc
      361 tgtccaagat gtcagtagca atcagcagga aatcgtcgta gcctttcgcc tgcgcctctt
      421 tggtcatggc attgatcaat tcgtcctgac gtgcgtaaat gtcgttcaga tcgacggtat
      481 tgacctgtcc gatgcgaata gacttgccgc ccatggtgaa actcttagca tcgccttcga
      541 taatgtccat atctgacttg gcggccaaat tagtgcctgc cttcagcatg gcaagaccat
      601 atgactgcaa atcaattccg gcaatcttcg ccatttctgg caaaatcttc ttatccttat
      661 cggttgcggt cggcgacttc aacaacagcg tgtctgaaat caaaccagaa gccatcaaac
      721 cagccaatgt tggcgaaatc ttgaagccat attcctggaa catctcaaaa atgacggtat
      781 tggtgctgcc aaccggttct gctcggtaaa acagcggcgc tgccgtgtgg aagttagcga
      841 tgcgatgatg gtcgacaaca gaatcaatcg tcacgtcttc gatatcactg acactttgtt
      901 gaaattcgtt gtgatcaacc aacatgacat gatccgtctc gttggctgcc gtcttgataa
      961 ctcgcggtgc ctgaaccttg aagtgatcaa ggacgaactt agtttcatcg ttcggttcgc
     1021 ctaatgctac cgcctcaaca tccgtgttgc ctgcctgttt ctgaaattct gcccagctca
     1081 tggcactcgt aatcgcgtcg gtgtccgggt tctgatgccc aaaaatcaaa gtcgtcatct
     1141 tatctgatcg ctcctcaact gaataattta cttatcaagt ttaacacggt tttcactgac
     1201 ccgcgacaag taatcttttt ccttcagata atcgtcaaag gtctggaaga agttcgagat
     1261 ccgcggaatg tcagctttct ctttgcgata aacaaaagaa atctcaaagc gaatggccgg
     1321 atcaaacgca atagcatagg ccttgatttg atcagcgcgt gcccgaacaa aactggttgg
     1381 taaggccgtg ttgacccctg acaagttaac gaattgggtt aactgatatg gcgtggtgaa
     1441 atgtgcgacc acgtgcggaa aatcaaccat ttgattcttg tacgcctcac gcagaagctg
     1501 tccaaggaaa tagtcgtcag gataagttgc ccaaggttca gctaaagtat ctttgaaatg
     1561 gattcgctta cggttagcca aggcgtcatc gtggtgcaag aacagcaatt gttcatcaat
     1621 aattttcttg ctggcgtatg gtttccagtt cttaatggtt tcatctggca gattcatgat
     1681 agccaaatca atctggttgt tttccaatga ttcccaaatt tcgtgacggg tcatcatccg
     1741 tagcgttact tcaacttcag gattcagttg atagtaatga gcaatgaacg caataaaggc
     1801 gctatcctcg attgagctta ataacccaat attgattttt ccgacggttg cactggttgt
     1861 ttgttgaatt tcgtcggttg tctggttcaa gatctcgtag atctcatggg ttgactttaa
     1921 catggtctga ccagcgtcag ataaatgcag tttcttcccg acagaataaa acagcggtgc
     1981 ccccactgtc cgttccaatt tcttgatctg ctgtgttaag gctggctggg taatgccaag
     2041 caattgggcg gcttgggtgt agttcatggt ttctgccaat tgcagaaaat aagttagtgt
     2101 ctttgaggaa aaaatgcgct cttgtttcgt tttcataggg cggcttccct ttcgtttatt
     2161 atttaataat atcgttcaac catcatcata agtggcaatg aaaaaaaacg caacgaattt
     2221 gccgcgtttt taatcgttac gttaagttct agctaaaaat tcagttgctc gcaactggtt
     2281 tcggacgcca gctttgccat ccggtataat ccttaacgtg cagcagattc tctgcattct
     2341 taacgcgatc ggcagacggc ggttcgatgc cttcaagcgg gtacgtaatg ccaagctcgt
     2401 gatacttttt aagcctaacg tgtgatacgg cagaatctca actttttgga ccacgttttt
     2461 gtccaatgtc gcaatatagt cccctaatcg tttgagataa gggtcaaagt cagtgcgttc
     2521 cgggaccaga acgtggcgaa tccacatgtc atcaccatgc gccgacatat actgcaccat
     2581 atctaaaata ttttcattag gaaaaccggt gagcttttta tgctcggccg aatcgatgtg
     2641 tttaatatca actaatgaga tgtcagtaac agccatcagc ttttcaaact ggccaaacca
     2701 cggttggtca cgcgtgaagg ggccgcctga cgtatcgagg caagtcgaaa ttcccagtgc
     2761 cttagccttg gtgaagagtt cgagaatgaa atcgatttgt accaaactct caccgccact
     2821 gcacgtaata cccccttggt caccccagaa tgctttatag cgctgggcat ccgccaaaat
     2881 ttgatcggcc gtcatttctt caccaacccc aatgttccag gtgtcagggt tgtgacaata
     2941 ctggcaacgc atgcgacacc cttgcataaa gacaacgaag cgaataccag ggccatcgac
     3001 cgaaccaaaa ctttcgaccg agtgaacata ccctttgatc gggccatcat gatcctgacc
     3061 aacttgttct aagatattta atgggctttg tgactgatcg atgagtttca tcttattgcc
     3121 tccactacaa catcatgtgt cgttttcaat tgattttcat ttcattctgc caaaaaacgg
     3181 caacagcatc gttgccgtct tttggcaaaa caggaatggc ttcctgtctt gagttaagct
     3241 gcttacattt cttcgaagaa ggtccgagca atgacatcgt cttgttgttc cttggtcaaa
     3301 tctgcgaagt agacgcagta gccagaaacc cgaacggtca atgttgggta ttcttctggg
     3361 tgcttctgag catcaatcag ggtctccttg ttgaagacgt tgatgttcaa atgcatgccg
     3421 ctgttttcca tatagccgtc aaccatgtga accaaggtat ccttacgagt ttcatcatcg
     3481 tggcccagtg tgttcggagt aaccccaaac gtattactaa tgccgtcagt tgcgtaatga
     3541 tacggaatct tggcggtgga catcaaggat gccaatgcgc cgttcttttc tgcgccgtat
     3601 gccgggttgg cacctggtga gaatggttcg cctttttgac gaccgtttgg tgttgtccct
     3661 gtattcttac cataaaccac gttggaagta atggtcagga cactggtact caacttcgcg
     3721 ccgcgataca gatgatgcgt gttcatcttg ttatagaagg tcttaaccaa ccacttagcg
     3781 atgtcatcag cgcgatcatc gttgttacca taacgtggat agtcatcatt gtcagcaacg
     3841 aagtcaactg caacaccatt ttcatcgcga attgccttga catgaccata cttgattgca
     3901 ctgatggaat caaccgcgtg tgacaggccg gaaatcccgg ttgcgaaggt ccggttcagt
     3961 tgggtatcct tcaatgccag ctgtgcagct tcataataat acttgtcatg catatagtga
     4021 atcacattca aagcattgac atacgtgtcg gccagccagt ccatcatctt gtcgaactta
     4081 ttcatgaatt ctttgtaatc aatgtaatcg ctggtgatcg gtgcatattc aggccctact
     4141 tgcgcttcct gaatttcatc tttaccaccg ttgatcgcat acagaaccgt cttagctaag
     4201 ttagcacggg caccaaagta ttgaacgcca tcagcaattg gttgtgccga gacacagcaa
     4261 gcaataccgt agtaatcggt accccattca ttgcgcatca ggtcatcatt ttcatattga
     4321 atggttgaac tttggatgga tacttcggtt gcatagcgtt taaagccttc tggcaagcgt
     4381 tcgctccaaa gcaaggtgat gtttggttct ggtgctgcgc ccatgttgtc caaagtcttc
     4441 aggaaacgga aagccgtctt ggtaacgtgg tgacggccat cattgcccat tcctgccaat
     4501 gacaaggttg cccagattgg atcgcctgag aacagtgagt tatattcttc agtccggatg
     4561 aaacgaacca tccgcaattt cataaccaaa tgatcaatca gttcctgtgc ctgttcttcg
     4621 ttcaatttgc ctaagcgcat atcgcgttgg atataagcat caataaccgt atcgatccgg
     4681 ccaacggaca ttgcggcacc gttttgagtc ttaacagcag ccagatagcc aaagtagatc
     4741 cactgaacag cttcttgcgc attagctgcc ggacgcgaga tgtcatagcc atattccttg
     4801 gccatcttct tcatgtcgtt taaggcacga tattgttcat tgatttcttc acgcaatttg
     4861 attacatcgt cagtcatttc gccgtcgccg gtcaagttat aatccttgaa cttctcagcc
     4921 attaaacgat cgatcccgta aacagcgatc cgtgggaaat cagaaacaat ccggccgcgg
     4981 ccgtatgcgt ctggcaagcc agtcacgatc ttgtaatggc gagcctttcg catatcaggg
     5041 gtataagcat caaagacacc ttggttatgg gtcttacgat attcattgaa aatcttgtgt
     5101 tcttgaggat ctgtcttgaa gccataagat tccaatgcat cttcagccat tcgaataccg
     5161 ccaaatggca tgaatgctcg tttgaatggc ttgtcggtct gaacaccaac aatcttttca
     5221 agatctttgt tcaaataacc agggccgtgt gaggtgatcg tagatggaat attgttgtca
     5281 gcatccaaaa caccgccatt tgcacgttct tgcttcttta aatttagaac ctgattgttc
     5341 aggactgttg tcgcttcagt ggggccagca aggaaacttt cgtccccgtc atattggttc
     5401 aggttatgct cgataaaatc gcgcacatta atttcttctt gccagtcgcc gccgttaaag
     5461 ccttcccaat aattaggaac tttggtttcg tcaagctgtt tcatagttgt ttgcctccta
     5521 aagtggatta cagatgtgac agttcttaca aacacagtat aacacgccgc caaatctatg
     5581 caagcgtttt attgcccata taataggcgt tatattgttt tttaagtgtg cttcgtcgct
     5641 tcttttcgcc catgatttcg gcattttgtt aaattgtgca caactggtct gtcctataat
     5701 aatcaaaaac gccaccatct gtattagtac agacggcggt gtcaatgatc accatttatt
     5761 cgacttgatc tgctggttct tctttggttt gaacaaaaac tggcttgcca aggacatcag
     5821 tgtcaatgac aaacgaacca ttcgaatagc ggtcacctgc tggatgttgt gccggattaa
     5881 gggtcgttac cttacccgta tcggtcaaaa cattcaggcg ggtagcgtca tcgactgaca
     5941 tcatcgcgac aatccgatgc ggatcacgct taagctcacg caagaccagt aaaccacgac
     6001 gggcacgact catttccccg acttcgctta aggccatctt tttgaaggcg ccacgttggg
     6061 tcaaaatacc gaccttagcc gtagttggat ccttcactag aatgaaattg acaacctcat
     6121 cgtctggctt tagatccata cttttaacgc cggttgcccg ggcaccgaca gttgacacat
     6181 cgcttaacgg gaatgtcagt ccgtaagcgt ggcggctgac cacaaagaca tcctgttgct
     6241 gatcagtcgt gaagtatgca ttggtgacaa tcgcggctgg gtctttcagc ttcatcgcca
     6301 tcatcggctt actcttgtac gtccgttgcg gctgcaaatc acttaaggca gtttgtttga
     6361 tgtacccgtc acttgaccct aacacaaaac tgccagcgcc atcgagttga tcaaaagcaa
     6421 acactgccaa gactttttcg tcagtgccaa ggccaactgt ttggcttaag tgttcgccgg
     6481 tgtctttcca acgcgcatca ctaatttcat gcactggtcg ataaatgaca tttccggcat
     6541 ttgtcacgat gtaaagatgc tgcaacgtac tcagttcgcc agtgaaaatg gcaagatcat
     6601 tggccttcaa accattgtcg gccggatcaa ccgcctgata actgcgcagt gaactgcgtt
     6661 taacgtaccc atcacgagaa acctgcacca tgacggtttc atcagccacc gtcaccgttg
     6721 tcgccacttc aagtgtttca attttggctt gaatgctgct gcgacgatca tccccgtact
     6781 ccttggcaat ccgcttcaac tcgccttcaa tcacccgatc gcgggcagcg gggcgggcca
     6841 aaatatcttg atactcggcg attgctttcg ccaattgtgc tgcttctttc tgtaaagccg
     6901 tgatatcggt attggtcaat cgatacagct gcaaggaaac aatcgcttcc gcctgagctt
     6961 ccgaaaaatc aaacttcttg actaagttac gcttagcatc ccctttatcc ttggaagcac
     7021 gaatcgcggc gatgacctga tccaaaatcg atagcatttt gatcaagcct tcgacaatgt
     7081 gctgtcgagc agcggccttg ttgaggtcaa aacgcgttcg ccgagtgacc acatcgcgtc
     7141 gatgttcgac gtatgcttcc aacatggcct taagtcctag caacttcggc tgcatgtcgg
     7201 caatagcgac catgttaaag ttgtatgcaa tttgtagatc ggtattttta aataaatagt
     7261 ttaagatgcc atgtgcatcg gcttcttttt ttaattcgat gacaacgcta agcccaaaac
     7321 ggtcgctttc gtcacggact tcggcgatac cgtccacttt tttgttgatg cgtaattcat
     7381 cgattttttt aatcatctgc gctttattga catcatacgg gatctcagtg accacgatct
     7441 tctcacgacc gccacgaatg gtttcgatgt gtgtccgaga acgaaccacg attttaccgc
     7501 ggccggtttc gtaagcttgc ttgatgccat caagcccttg aataatccca cctgttggaa
     7561 aatcgggacc cttgacgtat tgcattaaag tatctaaatc agcagtggga tgcttcagca
     7621 agtataagac ggcagcaata acttcccgca gattgtgcgg cggaatttcg gttgcataac
     7681 cggcagaaat accggtggca ccgttcacca gcaaatttgg aaacccagct ggcagcacag
     7741 tcggttcctg tgccgtgtca tcaaagttca acaccatatc gacggtttcc ttatcgatgt
     7801 cggccagcat ttccttgctg attttgctta aacgcgcttc cgtgtatcgc attgcagctg
     7861 gcggatcacc atccatggaa ccgttattcc cgtgcatctg aatcagtggg gcccgtaact
     7921 tccaatcctg gcttagccga accatcgctt cataaatgga gctgtcgccg tggggatgat
     7981 aattacccat gacattcccg acacttttag ccgacttgcg gaagccctta tcatacgtat
     8041 tgccatcttg gttcatcgca aataaaatgc gacgctgaac cggtttgagg ccgtcacgca
     8101 catcaggcag cgcccgttct tgaataatgt atttcgagta ccggccaaac cggtcgccca
     8161 tgacctcttc taaggtcagt tcttgaatct gattggccaa tggcttttac tttcctttct
     8221 tgtccagttg tttgacgatt tgcttggcac caaactgtaa tttttcgtga ttagcagtcg
     8281 gggtttccaa aatactgccg tcgtcatcca tatcaaactt gacgttatgc tcaatccatt
     8341 cacgacgcgg ctcaacgcga tcacccatca aagtggtcac gcgtcgttcc gccagctgag
     8401 catcgtcaat ccgaacccgg atcaaagtcc gcgtctcagg attcatagtc gtttcccaaa
     8461 gctggtcggc attcatttcc ccaagtcctt taaatcgggt caatgtgtaa cccttgccca
     8521 tggccttggt ctctttggcc aactcttcat cggtccaagc ataactgatc ttggttttag
     8581 caccagcgcc tttttgcagc cgatacaatg gtggcaaagc aatgtaaatt cggcctgcgt
     8641 caatcagcgg ccgcatgtag cgataaaaga aggttagtag caaaatctga atatgcgcgc
     8701 catcagtatc cgcatcagtc ataataatga ttttgtcgta gttggcctgc tgcagatcaa
     8761 aatccgcacc gacaccagcg ccgatggtgt aaatcatcgt attgatttct tcgtttttaa
     8821 cgatgtcctg taacttggcc ttctgggtat tcagtacttt ccctcgcaat ggcaagatcg
     8881 cctgaaactt tcggtctcgg ccttgtttag ctgaaccacc ggcagaatcc ccttcgacga
     8941 gatacaattc gttacgctta gggttcttgg tttgcgccgg ggtcaattta ccggaaagca
     9001 aaccttggtc cttcttgcgc ttgcgtcccg tccggctatc gtcgcgcgct tttcgagccg
     9061 cttcccgcgc atcacgggct ttgacggctt tacgaaccaa ctcttgcgac tcttcaccgt
     9121 tttccatcaa aaaagttgac agcttgtcat agacaatccc atcgaccaca gtgcgggctt
     9181 gcggcgtacc tagcttgccc tttgtctggc cctcaaattg caaaatttct tctggaatgc
     9241 ggacacttaa aatacctgca aaaccttcac gcacatcact gccttcaagg ttcttgtcgc
     9301 gttccctcag caagccgact tttcgggcaa attcattgaa tgctcgcgtc atgccgctgc
     9361 gcaagccaat ttcatgcgtc ccgccatcac cagtgcgaac gttattaaca aacgaaatca
     9421 ggttttcaga atagccatcg ttatattggc cggcaaaatc aaccacgata ccgtcctttt
     9481 tgccttcaaa attgatcacc tgtgacaatg cgtctttgcc ttcattaagg tatttaacaa
     9541 aactgaccaa gccatcagga tagtgataac tgtcgtgctt accggtgcgt tcatccgtca
     9601 gattaatcgt aatatttttc agtagaaagg ctgattcgcg caagcgttcg gccaaggtat
     9661 cataactgaa gacggtggtt tgaaaaatag tcgggtccgg cttgaatgtg atggtcgtgc
     9721 cattaggttc attaactttg cccaacttct gcaaactgcc atcaggatga ccgccattga
     9781 taaaatgctc ctcaaatgcg tgtttatccc gcacaactcg cacagtcaat gactccgata
     9841 gggcattgac gacgcttgag ccaaccccat gcaaaccacc agaagttttg taactatttt
     9901 ggttaaattt tccgccggca tgtagcacgg ttaaaatgac ttcaatcgtc ggtttaccac
     9961 tcgggtgcat ccccgttggc atccctcgac catgatcctg tacggtcaca gagttatcgg
    10021 cgtgaatcgt cacattgatc tcatccccaa accccgcgag cgcttcatcg acagagttgt
    10081 ccacgatttc atagaccaag tgatgcaaac cgcggccatc ggtggaacca atatacatcc
    10141 ccggacgctt ccgcacagct tccaagccat gcagcacctg aatggatgaa tcattatatg
    10201 cttgcgttgc tttatccata gtaaactccc ttttttgaac aactaagtta tagaatacac
    10261 cacgcgttga gatttcagaa ataaaaaata agagcgcgag ccagcccgat tagaaaccgg
    10321 agcataagcg gccttgggtg cgatggttgg gctttgacca ttgtgcccaa ggtccttatg
    10381 tgcaggtttc tgggctggcg agcgcgtttc agtagagcgc gagcaggagc ggttagcaac
    10441 cggagtgtaa gcggccttgg acgtgatggt cggctttgac cattgcggcc aagtccctta
    10501 cacgcaggtt gctgcgactg cgagcgcgtt tcaatagagc agcccgatta gaaaccggag
    10561 cataagcggc cttgggtgcg atggttggac tttgaccatt gcacccaagg tccttacacg
    10621 caggttgctg cgagtgcgtt taggcatcaa caccatcaac agcagacctc aacgtattgc
    10681 tctcaggact cctgttttct cctcaaaatc gacccagctg gctaatacca tcattgttca
    10741 tttaaatttt attagccgtg tcaatgtccc aaagctcagc agaaaaccgc acttccctaa
    10801 gcatggcaca taactatgac ttcttgacgt gaaattcatc gcccgctggc accatatcta
    10861 cgctgtgccc cgccatgatc cttgcgcaag acaacaccaa atcgcgccac aacccgcttc
    10921 acaggtttta ttcgaatgta cgttcgtttt attctactga cgtatcactc aaaagtcaaa
    10981 aatgctaaaa tagtttctag tttgagagga ggggcacatt tgatacttgt gctttgtttt
    11041 atactcgcgt atttcatagg cgccatcccg tttggtgtgg tcattggtaa actcttttat
    11101 cacacggata tccgcaaagg cgggagtcac aatattggca ccacaaatgc ctatcgcatg
    11161 ttagggccag tcggcggctc aattgtcttg gtgctggata tcttaaaagg cacgttggct
    11221 gccagcttac ccattctctt tggcatcgag catcattggc tggtgctgat cgtgggttta
    11281 gcggccgtat tcggtcatac attttcgatc tacattcgct ttaaaggcgg taaggcggtg
    11341 gcaactagcg ctggcatttt acttgcatat aatccgccat tttttgtcat tgcatttgcc
    11401 atctggttca gtttgatctt gctaacgtcc atggtcagcg ttgccagcac actgggtatg
    11461 gtgttgatca cagcttggtc gcttgtttac catgattggt tgctgacaac tgttgcctgc
    11521 gggttgctgg ttgtcttttt gatcaaacat cgggcaaact tcaaacgcat caaggccgga
    11581 gatgaaaata tggtgccctt tggcttaggc caatatcttc gtcaacaccg gggccgctct
    11641 tagtcacctt ttgatggcaa ccaaaaagac atccgaaact ggatgtcttt ttttcatgta
    11701 cctaatcgac aaactgatga caccttagaa aatgctgatc atgtaaccct tctcaaatgc
    11761 cgtgccaggt tcaagtcgat tgatcccgag tttgcgcgtc aggtcgccag tgctgccaat
    11821 cgtgtcggcg atgccccacc aaggttcgat gcagacaaag tcgccagtgg ttggatacgg
    11881 actccaaacg cccagatatg gggtatcggt catggtaacg ctgacaccat gtttcgtctt
    11941 gtcagaaacc aagttgaagg ttgtcttacc aagcaacgcg aaaattaaag catcatgatc
    12001 aaatgtttcg tgcgttaagg ccaaattggc atcagttgca gccaaggtcc ggtgcgtgta
    12061 atcaatgcct tcaccagcaa ccaatggaat ctgaacaagc gacttacgcg gtttgaagtt
    12121 caaataataa tcggagaatt gagtatccgg cgtcattggg accttgaagc ccggatggcc
    12181 gccgatgcta aagaacagtg gctcactttt gtccggattg tcaacgtgat acgtgacatg
    12241 tagattgtta ttttctagtg caaacgtgat gattaaacga aaagcgaacg ggtacatcgc
    12301 ccgcgttttg tcatcatcct tcagaacgaa gctcgcttta aacggtgtcg cagagagcac
    12361 cgtgaaatca cgatcacggg caaaaccgtg ctggcccatg tggtaagtct tgcctgcgta
    12421 atgatattga ttgtcagcca gcgccccaac aatcgggaac aagaccgggg cgtggcgacc
    12481 ccacaccgca ggatctgctt gccacagacg ctccctgcct gtcaggttat ctttgatact
    12541 ggtcagttca gcaccatgcc gactgatttt aactgtcaaa aagtcatttg caatcgttac
    12601 catacatcct catcctttac ctacaacatt attgttaact acaaaatata ccgcgtcatg
    12661 tttgaatcag ccgcaatatg gccaatcttg tcatccacat attgctgggt gacggtcaca
    12721 ctgcccatcg ccatatctgg accttcataa agtacgtctt caagcagttt ttcaagaatg
    12781 gttgccagtc gccgcgctcc aatattatca gtgtcgtggt tgacctgagt cgcaatctct
    12841 gcaattcgat caaccgcttc cttcgtgaag gtaatcttca cgccatctgc accaatcaag
    12901 gcgatatact gcttgatcaa agcattgtct ggctcggtca agatccgcac aaagtctttt
    12961 tcggttaagt ccttcaattc aacccgaatt ggaaaacgcc cttgaagttc agcaatcaaa
    13021 tcactaggct tagcctcggc aaacgcaccc gagccaatga acaagatgtg atccgtattg
    13081 ataggaccat acttagtgtt aatctgcgat ccttctacaa tcggtaaaat atctcgctgc
    13141 acaccttcac gcgaaacttc gccgctatta tgcttgtttc ctgcagcaat tttatcgatt
    13201 tcatcgatga aaatgatccc gttattctcg gcactttgaa tggcgtcgtg ataaatgtcg
    13261 gcatgattga ccagtttgtc agattcctct ttgatgaaga tttcgcgagc ttctttgacg
    13321 gtcatggtcc gctcaacctt tttcttaggc attaaagcgc caatagtgtc gcttagatca
    13381 atgcccatct gaccgtacat gtcacccatg ccaccgcctt ttttctcatc attgacagca
    13441 acggtgattt catgatcttc aagtaatcct ttttccagtt gctctgccac gctcaaacgc
    13501 ttattgcgaa tatcatcggt cacttcgccg cctgcatctg catcatcgcc agctggcatt
    13561 ttgccatttt gcatcccttg caacatgctc atcatctcgg ccatcggatt ggtattcttt
    13621 tccttacgaa tggccggcac taaaatttta accaaacgct tgttggcttc tttttcggca
    13681 cgtatgcgaa cctttgaaaa ttgcttctct tcttccatgg caacggcagt ttcggcaaga
    13741 tctcggacca tggattcgac atcacggcca acgtagccaa cttccgtaaa cttagtcgct
    13801 tccaccttca caaatggcgc ctcaactatt ttcgccagtc gtcgtgcaat ttcggttttc
    13861 ccgacaccgg ttggtccgat catcagtaag tttttcgggg taatctcttc ttgcattttt
    13921 ggcgataatt gcattcgccg ataacggtta tacaaggcaa ccgcgacggc ccgttttgca
    13981 tcatcttgtc caatgacata ttgatcgagt ttttcaacga tctgttttgg ggtttgtact
    14041 tctgccatca taagcctcct gtaggtcaat gtaattgccg acggttacaa actaaaagct
    14101 ttcgacaata acattgtggt ttgtgaaaat atcgatattc cctgcgatat tcactgcttc
    14161 tttggcaatg tcagctggtg tcatatctgg ggcatgccgc agcatcgcga ttgccgcggc
    14221 ttgcgcaaag ttgccgccgg agccgatcgc taccacgtct tcatctggat ctatcacttc
    14281 gccagacccg gatacaagta acaggtcatg ctcatccatc acgatcatca tggcttcaag
    14341 tttctgcaag gtcggatcct tgcgccaatc ttgagccagc gcaactgcgg aacgtcgcaa
    14401 gttgccagca taatgctcca gcttcttttc aaaccagtct tgcagggtga aagcatctgc
    14461 caccccgccg gcaaatccga tgacgacttg atcatgatag atccggcgaa ctttctgcgc
    14521 gttgcctttc atgatgacct tttcgccaag ggttacctga ccgtcaccgg ccaaagcggt
    14581 cacaccatct tttcttactg ctgcaattgt tgtcatagtc atgctccttt ttaagtgagc
    14641 gcgagcagaa gcgcttagaa accggagcat aagtgggctg caagcctaaa tggctgaatt
    14701 ttggctattt aggcttgcag gtcattatgt gtaggtttct gcgactgcga gcgcgttatc
    14761 tgcgtatctc gtcggataaa aacagctaaa gtagcgatta atctgttatc gccaatgttc
    14821 ttagcttaaa aaactcagac tgcttttgca tcatgcttta gtcttaatta tgcttcggat
    14881 aatatttcat atactcattt tttaaatgtg ccatggtgac atgcgtgtag atttgtgtgg
    14941 ttgataaact tgcatgaccc agtagctctt gaacagttcg caggtcagca ccatgatcca
    15001 gcatatgggt tgcaaaacta tgccgcagca tgtggggatg aatgttagct gtcagcgtcg
    15061 tctgcttgat gagctgatcc aaaatatatt caatgccacg cgaggtaatc ggacgcccat
    15121 actggttcac gaatacatat cgatgctgtg cctgactttt agccatcaag acttgtcggc
    15181 catcttttaa ataagttcgt agtgcttgct gagcgtactg tccaaagggc acatacctat
    15241 ctttgttgcc tttaccatga atcaacagta atgccgtatt gaaatcgacc tgattcaatg
    15301 tcagtttggc acactcggaa actcgaatac cggtgccata caaaacttcc aacaaagcgc
    15361 gattacgttg atccagcggg gttttgccag caactgtctt aaacagttcc tgaatctcgg
    15421 cttcatagaa aaattgtggt aaatgatgat gctgcttttt taattcaacc agctcaaatg
    15481 ggttgcgttt gacgacatca attc
//
