LOCUS       c00001_JAAJBL0..       15712 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAAJBL010000010.1 Limosilactobacillus reuteri strain VA24-5
            NODE_10_length_104642_cov_101.318098, whole genome shotgun sequence.
ACCESSION   JAAJBL010000010
VERSION     JAAJBL010000010
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 09:06:13
            Original ID  :: JAAJBL010000010.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 24041
            Orig. end    :: 39753
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15712
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[29041:34753]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..10712
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..15712
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15712
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             498..758
                     /locus_tag="ctg1_38"
                     /transl_table=11
                     /translation="MVKKQTTGRDQLGDFAPKFAELNDDVLFGQVWSREKELSPRDRSL
                     ITVTALITKEEIAEVITQLAFYVGWPNAWSAFNVAKKVWDD"
     CDS             complement(848..1990)
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 105.9; E-value:
                     2.8e-32)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_39"
                     /transl_table=11
                     /translation="MITIDTPNKQKVKMVAVLIFGAFIMMLTETFFNNALPTIINQYCV
                     SQSIAQWVSTGYQLVTGLMIPLSEWFFHRFNTKHTFISLLLIFLLGSACGFLASNFWLL
                     LLGRLIQAIAAGAMIPLIQNVVLVLYPQEKRGFIMGIINFTNGFITIMGLVVLVFFCWR
                     QLKLEKPLVNLSVFRNYTFNLTTILSAISNIALLSVELVLPLYLQRVHSLSAFQAGLML
                     LPGAILEGITSPIAGRLYDKFGIKKLSLIGYAIIILGTMPMIFFTPETNLLLVAGAYAF
                     RIIRIATVMMPTFTEGLNALPIDLYVHGNAAASTARQIAGSLGTAVLMMIIAFGSKHVA
                     GNNMLQAEQLNYGYRYAFLASFIFALIGFVLSFWLKSKQQ"
     CDS             complement(2048..2503)
                     /locus_tag="ctg1_40"
                     /transl_table=11
                     /translation="MKSIKLFTQDYIGPQIKTLSILIEKKMNAQLVANGISLTGTQISI
                     LAFLYDHQKTVTQKEIELKFKISHPTVRGIIRRLVALNLVETTTSDQDRRQIILMLSTQ
                     GQKFMKENLKIIQDPAKKMESRLRDNIKKSDYDTFQQVLHQMINNLQ"
     CDS             2709..3731
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053:beta-lactamase (Score: 115.1; E-value: 6e-35)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_41"
                     /transl_table=11
                     /translation="MKKFNLFALLMLTSLALFLASAQLKIKADPIDQQTQNQLQDYLKS
                     HHINGVMLVNGKGSKAVTITNRKTTNKREIVTANQLFPIASLQKIMTGTAIYQLKQQKQ
                     LTWDTSLHRYFPQIDGSDDITIRELMNHTSGLVNNDRPPFPLKGEKQQVAYMLKHLRNN
                     HVHTWDYQDVDYEMLAAIISKQTHLSYNAYIHKTFTKPLHLHQIKDFSEVKQKEIPQPM
                     DFAVDWHRVTITTSSDFGAGNLFMSPNNYWKFVYNDVLSNPKMIPAFYQQAKNQEVAYF
                     GGVYFDGDIIRANGSIPGYNCCFVANYKTKRMIMLFSNNIDYLTLKAASDDILHNYMDE
                     "
     CDS             complement(3826..4128)
                     /locus_tag="ctg1_42"
                     /transl_table=11
                     /translation="MTEFIKKNKWNIIVILVLSIACVYDAYNKSVIGFTSSMLCVIIWL
                     ISCLNKKYSYLAGIALILYAVFILITRADLWPGAVACIVIGLLILFFYRKKSQNG"
     CDS             complement(4678..4977)
                     /locus_tag="ctg1_43"
                     /transl_table=11
                     /translation="MNFFKNNKWNIIAILIFFGLCIYYVYDKNIVMTGYSLLGTILWLI
                     SCLKKKYSFLEGMALISYAVFILIIRQDLWPGAVACIVIGLLILFFYLKKRKYQ"
     CDS             complement(5001..5189)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_44"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 5e-11, bitscore:
                     35.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQQLKNEQLEFILGGNRWGNATIGAMSGAAIGINVCRAGGPWAMA
                     GCGVVGAGVKGYLSYHG"
     CDS             complement(5223..5429)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_45"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 4.7e-17,
                     bitscore: 55.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLDNFQLENILGGKNSWQQNVYGSVGVAAAGAGLGAAICGPAC
                     GFVGAHYGAIAWAGVTGATHGFH"
     CDS             5646..6080
                     /locus_tag="ctg1_46"
                     /transl_table=11
                     /translation="MNNKLLRWFYNISEPLTPQQQNFLGRVSFNIAVMLFIINIVLTLL
                     AIFIVTVTNNYEFAFNILMGALLLFTVFCVGGYSLYMKRQLRLHNTKTRSSHTAITNYF
                     YFHTSIASELRNPMNYIVPIVIGILYGLIIGIITWYKNKS"
     CDS             6490..7752
                     /locus_tag="ctg1_47"
                     /transl_table=11
                     /translation="MNILIQIISVVQALTFELFIFLYLVNIKVTKRDTFCLTIIFTIIF
                     LMIGCGYTWAYLSTILEGSFLYLYFKNRTSKPKLIGAILLTLTTSILTDFSTFTIDEVL
                     SLPTSYILFIDPFFYLFIFILLYHYNPLDKIEEENATINLWILFYLFITLNIAGFIIFT
                     TSRITPAFIVIFCLLVLQCSFTVFIYRISRQIQQKKLQLQEKKDLLFLIQNLEENQSKL
                     RRFKHDYQNLLNSLKLSAIHGDNQALLDKLESYSRDNLGKDSLWQFQDTKNIKDDVLRS
                     IFISKLNSIYQKDIKYHFECLTEINDLPNIDLFDLIRIIGIAYDNALEECETLKKLGAR
                     TVEINSMLYQSAPNKLEFEIKNTCRKQLSTNKIHQEGITNKTNHEGLGLATAQKIANKY
                     HNVYIAYSSDNGYFTFTISIE"
     CDS             7765..8535
                     /locus_tag="ctg1_48"
                     /transl_table=11
                     /translation="MDYHLLICDDDQLQAKNIATLLKMSSIILEEDDIHPNVDLIATDA
                     ASILDYLESNPDLTNIVAFLDIQLDENKQSQAGLALAQQIQKKHRNAQIIFITTHEELA
                     FLTFQRRINPLDYIVKTTDQRKLQRRLTETLELAIRHLNQFEYIQTHTFKYKIGTRIIN
                     VNFNNILYITTTKFPHKLKIVTINGQGEFFGNIKDVEQNYSFFFKASQSALINPQNIES
                     INTKSRIVTFINGDKIKFSRSRTKELNKIYKEKL"
     CDS             8553..10712
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 290.5; E-value:
                     4.4e-88)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_49"
                     /sec_met_domain="TIGR01193 (E-value: 2.7e-287, bitscore:
                     947.7, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 4.9e-41, bitscore:
                     132.6, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYNAFNKYYVSQVDEADCGVAALSMILRKFGSKVSLATLRKATKT
                     TTEGTTALGIVEAAKKYKLNVAAYQADINLFSSNEASYPFIAHLIKKDTGLLHYCVVVK
                     NAKNHLIIADPNPNIKVQKVSKEAFFQEWTGIAIFANPANDYKVIQEQLPTLKRLIVPV
                     IEQKKLLIGIVTSAFLVTFINIISSYFFQGLIDRLIPYKLLTPLNIICIELLIAYVANS
                     LFNFTRDYLLATLGQRLSKTILLDYIKHVLKLPMEFFSTRKTGDIVSRFTDANKVIDAL
                     VNSIISIFLDTTMLCVIGITLAIQNLKLFILTLITIPVYLVIIGSFTHSFKVLNQKEME
                     SNATVSASIIEDIRGIETIKSLNSEESRLTKIENEFNDFLHKSLTHTKLNSIQQSLKSF
                     TQLAFSLIILWFGAIQVINNQFTIGQLMTYNALLVYFITPLQNIINLQPKIQSAQVANN
                     RLNEVYMVQDEFIKKKLYHKITNGDIEIKNVNYSYQYNHPILKDINWKITPGTKMTVVG
                     MSGSGKSTLMKLLVNYFNPTSGQIFINGLNILDIDKTTVRSFINYIPQNPYVFSGTIKE
                     NLLLGSRKDITDEDITKACKVAMIHDDIMHLSLGYDSKLDENATTLSGGQKQRLTVARA
                     LLSPAKVIILDESTSGLDIITEEKLVKNLMNLTSKTIIFIAHRLSIAKITNNITVIDNG
                     TIVEQGTHNQLLKEHGLYFNLLQKY"
     CDS             10792..10902
                     /locus_tag="ctg1_50"
                     /transl_table=11
                     /translation="MINFIYQLVTKPNRFTIIWLIPIVSVIGTWLLKYFH"
     CDS             11623..12474
                     /locus_tag="ctg1_51"
                     /transl_table=11
                     /translation="MAYCIAKQAGLSTKNLKYSQLMTPLIRKVADQITFYTATDGNHGR
                     GVAWSAEKLGTHAIVKMPAGSTKIRAEHIAAFNNVNVEITDKNYDDTVQLAKQLAAKDP
                     NGILIQDMAWEGYTEIPQAISAGYSIIVTEILRQIDTDNYPTHIFLQAGVGQLSSGIID
                     ALYCLLLRDKRPVITIVEPATVACYYLSAQVADNNLHTVPGSPRTIMAGLICQTPSLIS
                     FPVIRDTASFYGTLTDNVARIGMRTLSTPVGTDPKIISGESGVAAFAYVNAVLQDQHLR
                     KK"
     CDS             complement(12683..13783)
                     /locus_tag="ctg1_52"
                     /transl_table=11
                     /translation="LQKIIAKRVSMLELFYDLIFVYAISKITAMIHHPVAGGIPLFNYI
                     EFVFVVIMVMQIWLYQALYINRFGKSRIIDTIGLLISMYAMTYLANNINTEWSVTFRTF
                     NSAVVLIVAGLIWQYLCGSGKHPMRDHDVRAFVVTLILELIAVLSGLLIGYHYGIFLCV
                     LGGLIGFLIPLVVYKQFVPENVNFPHLVERLGLIIIITFGESLVNITRYFNGSIIQPFP
                     ALIFVLLVTMFGAYIIQDKLLINHHQRSRGFVLMYSHVFMVIALLSMTAGLDYLAESGV
                     SRLNLWLLLAISILGYYICLVANGVYNHRDVKLQLKDYCVMLMIFLIGTGISFYGMQSN
                     FGLITGFALCGVSEFLWLLKISRIRK"
     CDS             complement(13999..14640)
                     /locus_tag="ctg1_53"
                     /transl_table=11
                     /translation="MNEKIDKNQNNKQNDPQQKKHPKLTKKMIVTMSICGGLLLGAGGT
                     LGIMAGHDHHEDVIAAVQRKKANKADIKIDQQAAIDKFYEKYKDKQINEVKLEPDHGQY
                     VYKIKGFDNTNEYKVKVNAKNGKVISSKTEKLENGEKKYSLDPSKAISRDEANTIAEKA
                     AKKGSGVEWELKQETKNKSVWEVKVNDNNKTKEVNINATSKKVLSVDNDH"
ORIGIN
        1 ttgatgcata tctagatctg ttttccgaaa aaagtgcgtt aacagctgtt gttaactggt
       61 accgtgctct tcttcaatta ccgcagattc aatacaagca agtcaccgta ccaaccaaat
      121 ttatttgggg caatcaagat cttgcaattg ccaggagtgg tgttgagcga aaccgtcagt
      181 atgtcagtgg tccttatcaa tttgttgaat tagacgcggg acattggttt atggaattta
      241 atcaagaaga aatctgtagg caaatcattg agaacattga agactattct tatagctagt
      301 aaactaatca tcattaaata tagttgtctt tgtccactaa ctagcaaagt attaaatcac
      361 acctagttgc ttttgtctac tacttattta aaattcactt tttgcataga taattactta
      421 atatgagtat ttcttatttt atttaatcta gtttatatta aagataacta aagagaactt
      481 tgaaaggagt ctttatcatg gtaaaaaaac aaactactgg tcgcgatcaa ttaggtgatt
      541 ttgcccctaa atttgctgaa ttaaacgatg atgtgctatt tggacaagta tggtcccgag
      601 aaaaggaatt aagtcctcgt gatcggagtt taatcacagt taccgcttta atcactaaag
      661 aagaaattgc agaagttatt acccaacttg ccttttacgt tggctggccg aatgcctggt
      721 cagcattcaa cgttgccaag aaagtttggg atgattaatg tttacagact gagaattaac
      781 tcaacagaaa aacaccgaaa atcagcttgc cagccgattt tcggtgtttt tctcactctc
      841 tatgaagtta ctgctgtttt gatttcaacc aaaatgataa gacaaaaccg attaaagcaa
      901 aaataaagga agctaaaaat gcgtatcgat acccatagtt aagctgctca gcctgcaaca
      961 tattgttacc tgctacgtgc ttactaccaa aggcaataat catcattaat actgctgttc
     1021 caagtgaacc ggcaatctgg cgagcagtcg atgctgcagc atttccatga acatataagt
     1081 caattggtaa cgcgttaagt ccttctgtga acgttggcat cattacagta gcaattctaa
     1141 taattcggaa agcatatgct cctgcaacaa gtagcaaatt agtctctgga gtaaaaaata
     1201 tcatcggcat agtccccaaa ataataatag catagccgat taatgagagt ttcttaatac
     1261 cgaatttatc atatagtctt ccagcaatcg ggcttgttat tccctccaaa atcgctccag
     1321 gtaagagcat cagtccagcc tgaaatgctg aaagactatg aactcgttgt aaatatagtg
     1381 gtaagactag ctcaacacta agtaatgcga tattactaat tgcacttaaa atagtcgtta
     1441 aattaaaagt ataattccta aaaacactta aattcaccaa tggcttttct aactttaatt
     1501 ggcgccagca gaaaaatact aatacgacaa gccccattat tgtaataaag ccatttgtaa
     1561 aattaattat tcccataata aagcctcgtt tttcttgagg atagagtacg agaactacat
     1621 tttgaattaa aggaatcatt gccccggcag cgatcgcttg aattaatcgg ccaagtaata
     1681 atagccagaa attacttgct aagaagccgc aagctgaacc gagtaagaaa atcagtaaca
     1741 ggctaataaa agtatgttta gtattaaaac ggtggaaaaa ccattcggat aacggaatca
     1801 ttaatcctgt cacaagttgg taaccagtgc taacccattg cgctattgac tggctaacac
     1861 agtattgatt aataattgtt ggtaaagcat tgttgaaaaa tgtttcagtt aacatcatta
     1921 taaatgctcc aaagattaat actgctacca tttttacttt ttgcttatta ggtgtgtcaa
     1981 ttgtaatcat aagttttttc tccttctaaa tgtagctagc tacactttag cctaaaaata
     2041 aagcaggtta ttgcaaatta ttaatcatct gatgcaatac ctgctgaaaa gtatcgtaat
     2101 ctgacttttt aatattatct cgtaatcttg attccatctt tttagctgga tcttggatta
     2161 tcttcagatt ttctttcata aatttttgtc cttgagttga taacattaaa ataatttgac
     2221 gcctgtcctg atcacttgta gttgtttcaa ctaaatttaa tgcaactaat cgccgaatta
     2281 ttcctcgcac agtagggtgg ctaattttga actttaattc aatctctttt tgggttaccg
     2341 tcttttgatg atcatataaa aaggctaaaa ttgaaatttg ggtccccgtt aagctaattc
     2401 cattggcaac caattgagca ttcatctttt tttcaatcaa aatactcaga gttttgattt
     2461 gaggtccaat ataatcctgt gtaaatagtt ttattgactt cattctttgg catcccctct
     2521 ctcaacaact gtagctcact acatattttt gaataataca agaaaagcac ataattttac
     2581 ttcttccgtt tggttgcttt tctctaccac ttatttaaaa tccactcctt ttgatagcgg
     2641 ttactttcct tgcccaatca gtaaaacaag ttcatactaa tagtatccta ttaggcaagg
     2701 tgtcaattat gaaaaaattt aacttatttg cccttttaat gcttacttcc ctagcattat
     2761 tcttggcatc cgcacaacta aaaattaagg cagatccaat cgatcaacag actcagaacc
     2821 aacttcaaga ttacctgaaa tcgcaccata ttaacggcgt aatgttggtt aatggtaaag
     2881 gaagcaaggc agtcacgata acaaatcgca aaaccaccaa taaacgggaa attgtcacag
     2941 caaaccagct atttccaatt gcttctctcc aaaagatcat gactggaacc gcaatttatc
     3001 aattaaaaca acaaaaacag ctaacctggg atacctcctt gcaccgttat ttcccgcaaa
     3061 tcgatggtag cgatgatatc actatccgtg aattaatgaa ccataccagt ggcctcgtta
     3121 ataacgaccg tcccccattc ccattaaagg gagaaaaaca gcaagttgct tacatgctaa
     3181 aacatttgcg gaataatcat gttcacacct gggattacca agacgtagac tatgagatgt
     3241 tggcagcgat cattagtaaa caaacccact tgagttacaa tgcttatatt cataaaacct
     3301 ttaccaaacc tctccatctc caccaaatta aagacttttc ggaagttaag cagaaagaga
     3361 ttccacagcc aatggatttt gctgttgact ggcaccgagt aaccattacg acttcttcag
     3421 attttggggc aggcaatctt tttatgtcgc ctaataatta ctggaagttt gtatataatg
     3481 atgttctgag taaccctaaa atgatccctg cattttacca acaagccaaa aatcaggaag
     3541 tcgcttattt tggcggagta tattttgacg gtgatattat ccgcgctaat ggaagtatcc
     3601 ccggctacaa ctgttgtttt gttgcgaatt acaaaacaaa gagaatgata atgctttttt
     3661 caaataatat tgattatctg acccttaaag cagcatcgga tgacatattg cataactata
     3721 tggacgaata attaaaataa cgacttaaaa aataaggttc catttacact gtttttgtag
     3781 acggaacctt attctttgtt atttaaagct gatagtttga ttaacctagc cattttggga
     3841 tttttttcgg taaaaaaaca agattagtaa tcctattact atacatgcga ctgctcccgg
     3901 ccataaatct gcccgagtaa ttaaaataaa cacggcatat aagattagtg ctattcctgc
     3961 taagtagcta tattttttat ttaagcaact aatcagccag attattacac aaagcataga
     4021 agacgtgaaa ccaataacgc ttttgttata tgcatcgtat acacaagcaa tagaaagtac
     4081 taatattaca attatattcc acttattctt cttaataaat tctgtcatga ttactacaga
     4141 atatcctcct aactcttaaa atagactatc aggataacta atgcaattac gaacaaaatt
     4201 gcagatacta gccacatgct tgaacttact ataaaaagca ataatccata cgatataaat
     4261 aatatcgact gtagatataa aaattttcta cctaaattac taattattag tgaaactcca
     4321 caaaaaatcg acattgagat cataccaaaa ttataatcaa atattaaata catcaaagca
     4381 atagtaaaaa aaattaatgg gtctacgaaa tctttcttta taataatttt ctcctatatt
     4441 tataaacgat atccgacgta tccaccgatg ccacaagttg ggccacaaat agctgtacct
     4501 agttctgcac ctgcagcagc aaaatcaaca gaaccagaaa cattctgctg ccatgagttc
     4561 ctatcaccta gaatattttc tagcagaaca attcagcaat caagtcgcct aaactaattt
     4621 tatctattta acctgtatcc ttgacaggac atagtgcctt agacatttgt ttttggctta
     4681 ttggtactta cgttttttta ggtaaaagaa caaaattaac agcccaatta ctatacatgc
     4741 tactgctccc ggccataggt cctgccgaat aattaaaata aatacggcat atgagattag
     4801 tgccattcct tctaagaaag aatatttttt cttcaaacaa ctaatcagcc aaagtattgt
     4861 acctagtaag gaataaccgg tcataacaat gtttttatca taaacataat atatacaaag
     4921 gccaaaaaat attaatattg caattatatt ccacttattg ttcttaaaga agttcattaa
     4981 cattaatgta tattgaaaaa ttaaccgtga tagctgaggt aaccctttac gcctgctcca
     5041 actactccac aaccagccat tgcccaagga ccaccagcgc gacaaacatt tattccaatt
     5101 gctgctcccg acattgcacc aatagttgca tttccccatc gatttccgcc aagaataaat
     5161 tctaattgtt cattttttaa ttgttgcatt attatttttc ctcccttttt atttctaaag
     5221 ttttaatgaa atccgtgtgt agcgccagtt actcctgccc atgcaatagc accataatgg
     5281 gcaccaacga atccacaggc tgggccacaa atagctgcgc ctaatcccgc acctgcagca
     5341 gccacaccaa cagaaccata aacattctgt tgccatgaat tcttaccacc tagaatattt
     5401 tctaattgaa aattatctaa ctttttcatt tatagttaac ctccttaagt tactatgttt
     5461 taagcctata acaatttcac atcacctaat aaagattttc taattctgtc attttaagtt
     5521 cgtattccat tcagtcaatc aaatatgtag caattcttct aaaattagat gaaatttctc
     5581 gtcataaagt tgatttgcta tagttataag ttagattatc tttacgaaag gaacatcacc
     5641 ataaaatgaa taataaactt cttcgttggt tttataatat ttctgagccc ttaacccctc
     5701 aacaacaaaa ttttcttggc cgagtcagtt tcaatattgc tgtaatgtta tttattatca
     5761 atattgtcct gacattatta gctatcttta tcgtcacagt aaccaataat tacgagtttg
     5821 cttttaacat tttaatgggt gcccttttac tttttacggt attttgcgtt ggcggatatt
     5881 ccctttatat gaaacgtcag cttagactac acaatacaaa aacaagatct tcacatactg
     5941 caataacaaa ttatttttat tttcacactt ctatcgctag cgaactacga aacccaatga
     6001 attatattgt tcctattgtc ataggtatac tttacggtct tattattgga ataattactt
     6061 ggtacaaaaa taaatcgtag taccattctc atagaatttc gctaagttaa tcaaatgctg
     6121 aattattagc gtctgatctg ccagtctatt aatgcggtgt tacattacta tctttaaagt
     6181 agtgaagaag atgtggtgat ttccagtctc tttttcatta ttagacatat ttgctaaatt
     6241 ttttacagaa tttgaatacc aaacaaccac ttttgatcat ttatgatttt atcgatatat
     6301 cctgttaaaa taaattactg ataaaacaat aggagagatt tatttatgaa aaactatcaa
     6361 ctcagcaact atctttgatt aaaggaggtt atggttatat actcacattt aaatctgcaa
     6421 ataataatac atatacttat agcaacaaaa tcataaacag tttacgacat attttccatt
     6481 aattttaata tgaatatttt gattcaaatt atttcagtag tccaagctct tactttcgaa
     6541 ctttttatat tcttatacct tgtaaatatt aaggtcacta agcgagatac attctgctta
     6601 actattattt ttaccattat atttcttatg attggctgtg gttatacatg ggcatatctg
     6661 tcaacaatat tagaaggtag tttcttatat ttatatttta aaaatagaac ctctaagcca
     6721 aaattaattg gtgctatcct attaacttta actacatcaa ttttaactga tttctcaaca
     6781 tttactattg atgaggtact ctcactacca actagttata ttctattcat tgatccattc
     6841 ttttacttat ttatctttat tcttctctac cattacaatc ccctcgacaa aattgaagaa
     6901 gagaatgcaa ctatcaattt atggatctta ttttaccttt ttattacttt aaatatcgca
     6961 ggatttatta tttttacaac ttcgcgaata acgccagcct ttattgttat cttttgctta
     7021 ctagttcttc aatgtagttt tacggtcttt atataccgaa ttagcaggca aattcagcaa
     7081 aagaaactcc agcttcaaga aaagaaagac ttattatttc tcattcaaaa cctagaagaa
     7141 aatcaatcga agttaagacg atttaaacat gattaccaaa acttactaaa tagcctcaaa
     7201 ttaagtgcca tccatggtga taatcaagcc ttacttgata aattagaaag ctattcccga
     7261 gataaccttg gtaaagattc tctttggcaa ttccaagaca ctaaaaacat taaagatgat
     7321 gtcttgcgaa gtatctttat tagtaaatta aattcaattt accaaaaaga tattaaatat
     7381 cattttgaat gtttaactga aattaatgat ctcccaaata tcgatttatt tgatttaatt
     7441 cgaataattg gaatcgctta tgataatgcc cttgaagaat gcgaaacctt aaaaaagtta
     7501 ggagcacgta ctgtagaaat caattcaatg ctgtatcaaa gtgcacctaa caaattagaa
     7561 tttgaaatta agaatacttg tcgaaagcag cttagcacca ataagattca tcaagaagga
     7621 attacaaata agactaacca tgagggactg ggattagcaa cggctcaaaa aatagctaac
     7681 aaataccaca acgtatatat tgcttactcc tccgataatg gttactttac atttacaatt
     7741 tcaattgaat agaaaggaat acttatggac taccatctac tcatttgcga tgatgaccag
     7801 ctacaagcta aaaatattgc cacattatta aaaatgtcgt caattattct ggaagaagac
     7861 gatatacacc ctaacgtgga tctaattgcc actgatgcag ctagtatttt agattatcta
     7921 gaatctaatc cagacttaac taatatcgtt gcgttcttag atattcaatt agacgaaaac
     7981 aaacaatctc aagcaggttt agcattagct cagcaaattc aaaaaaagca ccgtaacgcc
     8041 caaattatct ttattaccac ccatgaagaa cttgcttttc ttacctttca aagacgaatt
     8101 aatccattag attatattgt caagacaact gaccaacgaa aattacaacg gcgattaaca
     8161 gaaacattag agttagcaat taggcacctt aaccagtttg agtatattca aacacacaca
     8221 tttaaatata aaattggtac gcgaattata aacgtaaatt tcaataatat tctttacatt
     8281 actactacta agtttcctca taagctaaaa atagtaacta ttaatggaca aggagaattt
     8341 ttcggcaata taaaagatgt cgaacaaaat tattcgttct tttttaaggc atcacaatca
     8401 gctctgatca atccgcaaaa catcgaatca atcaatacaa aaagccgaat cgtaacgttt
     8461 atcaatggcg ataaaattaa attttctcgg agtcgaacaa aagaactaaa taaaatctat
     8521 aaggagaaat tatagattag tggggtattt ttatgtataa cgcatttaat aaatactatg
     8581 taagtcaagt tgacgaagca gattgtggag tagccgcact atccatgatt cttcgtaaat
     8641 ttggctctaa agtttcactt gcaactttaa gaaaagctac taaaacaact actgaaggta
     8701 caactgcttt aggtattgtc gaagccgcta aaaagtataa gcttaacgtt gctgcttatc
     8761 aagcagatat aaatcttttt agctctaacg aagcttctta cccttttatt gcacatctca
     8821 ttaaaaagga taccggctta ttacattact gtgtagtcgt taaaaacgca aaaaatcatc
     8881 ttattattgc agatccaaat ccaaacataa aagttcaaaa ggtatctaaa gaagctttct
     8941 ttcaagaatg gaccggaatt gcaattttcg ctaatcctgc taatgattat aaagttattc
     9001 aagaacaatt acctacacta aagaggttaa tcgttcctgt catagagcag aagaagttat
     9061 taataggcat tgttacatca gcatttttag taacatttat caatataata agctcatact
     9121 ttttccaagg cttaattgat agattgatcc cttataaatt gttaacacct ttaaacataa
     9181 tttgtattga actactaata gcatatgtag caaattcatt atttaacttt acaagagact
     9241 atctattagc aactctaggt caaagactat cgaaaactat tcttctagat tacattaagc
     9301 atgttcttaa actccccatg gaattctttt caactagaaa aacaggagat atagtttcaa
     9361 ggtttactga tgctaataaa gtaattgatg ctcttgttaa ttctataata tctatttttc
     9421 tagacacaac tatgctatgc gttattggta ttaccctggc aattcaaaat ttaaaactat
     9481 ttatactaac tttaattaca attcccgtat accttgtcat aataggttct tttacccact
     9541 cattcaaagt tctaaaccaa aaagaaatgg aaagtaatgc tactgtaagt gcatcaatta
     9601 tagaggatat ccgtggaatt gaaactatta aatcactaaa tagtgaagaa agccgtttaa
     9661 ctaaaattga aaatgaattt aatgattttt tacataaatc attaacacac actaaattaa
     9721 atagtattca acagagcctt aaaagcttta ctcaattggc atttagcctc atcattcttt
     9781 ggtttggtgc aattcaagtt attaacaacc aatttacaat aggacaattg atgacgtata
     9841 acgcactcct tgtatacttt attacaccac tccaaaatat tattaattta cagcctaaaa
     9901 tccaaagtgc tcaagtggca aataatcgtt taaatgaggt ttacatggtc caagacgaat
     9961 tcatcaaaaa gaagttatat cataaaataa ctaatggcga tattgagatc aaaaatgtta
    10021 attatagtta tcaatataat catcctattc taaaagatat taattggaag attacgccag
    10081 gtactaaaat gacagtcgtc ggtatgagtg gttcaggaaa gtccacattg atgaagctct
    10141 tggtaaatta tttcaatcct acaagtggac agatttttat taatggttta aacattttag
    10201 atatagacaa aacaactgtg cgatctttta ttaactatat tcctcagaat ccttatgtat
    10261 tctctggaac aattaaagaa aacttacttc taggaagtag aaaagacatc actgatgaag
    10321 acattactaa agcctgcaaa gttgcgatga ttcatgacga tattatgcac ctatcgttag
    10381 gatatgatag taaactagac gaaaatgcta ctaccctttc aggtggacaa aagcaacgtc
    10441 ttacagttgc ccgtgcattg ttatccccag ccaaagtcat tattctcgat gaatcgacaa
    10501 gtggattaga catcataaca gaggaaaagc tagtcaagaa tcttatgaat ctaacttcaa
    10561 agactattat ctttattgct caccgccttt caatcgcaaa gattacaaat aatattactg
    10621 taattgataa tggaacaatc gtagaacaag gaactcacaa tcaactactt aaagagcacg
    10681 gtctgtattt taatctactt cagaagtatt aatatagact cttactaacc cacatctttc
    10741 aatcaatgaa ttttttaatt attttatatt tactttaaaa gaggtaatat tatgatcaat
    10801 tttatttatc aattagttac taagccaaat cgttttacaa ttatttggct aatacctatt
    10861 gtttccgtta tcggaacttg gctattaaaa tatttccact agtgccacct aatttttagg
    10921 attatctctc ctaatgaagt tcaactgaaa ttaaagctac tcctcgcagt agaacacgtt
    10981 atacttaata caaaaactag aaaagttatc gtttgcgctt atgtagaaga aggtgtcccc
    11041 atgtttgacg atatcttaaa atataaaaag tggccattat ggaagagaat actataccta
    11101 attctaatgg ctttaccttt accaattaaa taatgcggtc ccatttgtat tgaatggatc
    11161 taatgctaga aaataactta actcatttta aaatataaca aatacaaaag ccttcagtag
    11221 cttaagaccc tgctgaaggc ttttgtgcgt agttagagtc ttcgcttata ccaatattaa
    11281 tacttacgct tgtttagccg ccacgcaatt acgtatctta agtgtatttg acatagatca
    11341 tcagactttg ttagcttgaa tattaaggag gaaactaatt attacagaaa tccaacttat
    11401 taaatcacca tttgagattg gcaatcatcc ctttaatgat gctaaaattg tgaaacaagt
    11461 tgcaaacttt tatcaatcag taccttttta tcagccaaca ccattaatta atttgaatca
    11521 gtatgctaaa aaaataatat aggtaacctt tatgtaaaag atgaatctca acggtttagc
    11581 aaagccctaa aagtctttaa agctactggt ggtttatacg caatggcata ttgtattgct
    11641 aaacaagccg gattatcaac aaagaatttg aaatattctc aattaatgac accgttgata
    11701 agaaaagtcg ctgatcaaat cactttttat actgctactg atggtaatca tggccgcggt
    11761 gtggcttggt cggccgaaaa attaggcact cacgcaatag ttaagatgcc tgcgggttca
    11821 actaagatac gtgcagaaca tattgctgca tttaataatg tgaatgtaga aataacagat
    11881 aaaaactacg acgatactgt tcagcttgcc aaacagcttg ctgctaaaga tccaaacggg
    11941 attctaattc aagatatggc ttgggaaggc tatacagaaa ttccacaagc gatttctgca
    12001 ggatattcta tcattgtcac cgaaattctt agacaaattg acaccgacaa ttatcctaca
    12061 catatcttct tacaagcagg agtcggtcaa ttatcatctg gaattattga tgccttgtat
    12121 tgtttattgc taagagataa acgcccagta attacaattg ttgaaccggc aacagttgct
    12181 tgttactatc tatccgcaca ggtggcggat aataacttgc acactgttcc tggatcacct
    12241 cgcacgatta tggctgggct aatttgtcag acaccaagtt taatttcatt tccagtaatt
    12301 cgtgatactg ccagctttta tggaacacta acagataacg ttgcacgaat tggaatgcgc
    12361 accctatcaa cccccgttgg aactgatcca aaaattattt ccggtgaatc tggagttgca
    12421 gcctttgcct atgttaatgc cgttctccaa gatcaacacc tccgtaaaaa ataggattag
    12481 acaccaaagc acgagtacta atcattaata ccgaaggcga tacagacgag cagatatatc
    12541 aagaaataat taaaaacaat tagctaaaaa gtagttattt caatttcata tttatgtctt
    12601 gaaataagta gatctttttt accgaaaacg ggatagaaaa tttaacttta ccaaattatc
    12661 tatcccgttc ttcgatctct aactatttcc ttatccggct tatctttaat aaccatagaa
    12721 attcactaac gccacaaaga gcaaaaccgg taattaagcc aaaattactt tgcatcccat
    12781 aaaatgaaat tcccgtaccg attaggaaga tcatcaacat cacacaataa tcttttaact
    12841 gtaatttaac atcacgatgg ttataaacgc catttgccac aagacatata tagtatccca
    12901 aaatactgat agccaataat agccacaaat tcagccgtga tactcctgat tcagcaagat
    12961 aatcaagccc tgccgtcatc gagagaaggg caattaccat gaatacgtgc gaatacatta
    13021 ggacgaatcc gcgtgaacgc tggtggtgat taatcagcag tttgtcttgg ataatatatg
    13081 caccaaacat tgtcaccagt agtacaaaaa ttaatgcagg aaacggctga attatcgaac
    13141 cattgaagta gcgcgtaata ttgactaacg attcaccaaa agtaatgata ataattaagc
    13201 cgagtcgttc tactaaatgc ggaaagttca cgttctctgg gacaaattgt ttatatacaa
    13261 ctaatggtat taaaaagcca atcaagccac ccaatacaca caggaaaata ccatagtgat
    13321 aaccgattag taagccgctt aacacagcaa ttagttctaa tattaaggtt actacaaagg
    13381 cccgaacatc atgatcgcgc atcgggtgtt ttcctgaacc acagaggtac tgccaaatta
    13441 agccagcaac tattagtacc actgccgaat taaaagttct aaatgtgact gaccattcag
    13501 tgttgatatt attagcaaga taagtcattg cgtacatact tattagcaaa ccaattgtat
    13561 caatgatgcg acttttgccg aagcgattaa tatataatgc ctgataaagc caaatctgca
    13621 ttaccataat aacaacaaaa acaaattcaa tgtaattaaa tagcggaata ccacctgcaa
    13681 cgggatgatg aatcattgcg gtgattttag aaattgcata gacaaaaatc aggtcataga
    13741 acagttccaa cattgaaacc cgtttagcga tgattttttg caaaacgctc ccccctccta
    13801 atttgataaa taaaattgtt agattactcc tgttaagttt atcaaattac taataatccg
    13861 caataatttc tcttgtacca tatataaaag cgttcaagta gtcatcaaca cgattacttg
    13921 aacgcttatt taattatcta tttattttta atgtttcata tgaaacatta aaaataatca
    13981 atttacaagc cattaaattt agtggtcatt atcaacgctt agtacttttt tagaagtagc
    14041 attaatattt acttctttag tcttattgtt atcattgact ttaacttccc aaacgctctt
    14101 attctttgtt tcctgcttca attcccattc aacgccactg ccttttttag ctgctttttc
    14161 agcaattgta tttgcttcat cacggctgat cgctttactt ggatctagtg aatatttttt
    14221 ctcgccattt tctagttttt ctgttttgct agaaatcact tttccgtttt tggcgttcac
    14281 cttaacttta tactcgtttg tgttatcaaa gccctttatt ttgtacacat attgaccatg
    14341 atcgggttct aatttaactt cattaatttg cttatcttta tatttctcat aaaatttatc
    14401 gattgccgct tgctgatcaa tttttatatc tgctttattt gccttttttc gttgaactgc
    14461 tgcgattaca tcttcgtggt gatcatgacc tgccattatt ccgagcgtcc caccagcgcc
    14521 taataataat cctccacaaa tactcatagt tacaatcatc tttttagtta attttggatg
    14581 cttcttttgt tggggatcat tttgtttgtt attttgattt ttatcgattt tttcattcat
    14641 tttaactaac tcccttcaag gttttgcttt agcttataac tatattttat gaggggatct
    14701 cctaaaaata accaaaatta ggtgaaggta tgatgaaaaa atcttcattt ttgttgagaa
    14761 agataaattg taaaaatcgt tccttgtggc tgattagact gcactttaat ttcaccctta
    14821 tatttttcaa caatcttttt tacaatcgct aaaccaattc cagaacctgc aatgcggcta
    14881 gcatgtgacg tatcctctct gaaaaagcgt tcaaaaattt tttgccgatt ttctttggca
    14941 ataccgcaac cctggtctat tacttggaac ataatttgat tgtttattga atgcaaacta
    15001 actttaatta tcgaattaag tggtgaatac tttgccgcgt tttccaatac attgtgaaca
    15061 agactttgcc aatcaccagt tactatttga tattctaacc gttctggcat atccataatg
    15121 aattttcttt tatatgctcc ctgcaaggag gttatttctg tcttaataat tgctggcaaa
    15181 ttagttaagt catgtgaatt ttttgattga tgtccctcta atatcaataa ctcgtttacc
    15241 aagcgttgca ttcgatgcgc ctcttgatca atatatccaa tagatttctt aattaattct
    15301 ggatgcgtat caccatggcg tttaattaag tttacgtgcc ctaaaattcc tgctaatggt
    15361 gtcttcaatt catgcgaagc gttagtgata aactcctttt cacgttgaat tgcttgaaat
    15421 tgacgttcaa gtaactcatt aaatgattta gcaacattac ttacttcaat aggttgttcg
    15481 ggaacggtta aaatttgtaa tttactactc tgcggattaa tgctgttagt ttgtaaactc
    15541 aaattagtta atggtttagt ccaccgatgt gctaagtgac gaattaatgg aattgatagc
    15601 agaactactg ccaagttaat tacaaccatt aatcccagta accaattcgt taatttaaca
    15661 aggtcatcaa cattaatcgc aactttaaca aaactattag ccatcttttc ct
//
