LOCUS       c00034_JAANTB0..       13038 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAANTB010000040.1 Limosilactobacillus fermentum strain CVM-347
            NODE_40_length_13038_cov_176.877546, whole genome shotgun sequence.
ACCESSION   JAANTB010000040
VERSION     JAANTB010000040
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-19 22:59:25
            Original ID  :: JAANTB010000040.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13038
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13038
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2357:10240]"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2358..10240
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     cand_cluster    1..13038
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13038
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="betalactone"
                     /region_number="1"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     CDS             2..82
                     /locus_tag="ctg34_1"
                     /transl_table=11
                     /translation="YLNMTVYHGIEKDDNSEEAGMLKLVK"
     CDS             complement(47..346)
                     /locus_tag="ctg34_2"
                     /transl_table=11
                     /translation="MVIDTHTEIYDLLREYERTCVTITFKDGTSKKIFFLDVDDEYQEN
                     DVRPEKDCIVYNITDSISYGNGIPLDKLRSSPKCWCKLNSANLSFHKLKHTGFF"
     CDS             complement(713..1657)
                     /locus_tag="ctg34_3"
                     /transl_table=11
                     /translation="MTRKVAVVGMGHVGATVAHYLVAGGFTDDLALYDTNEAKVRADAL
                     DLRDAMANLPFHTNLTVNDDSQLADCDVVISTLGKSKLVDTPDHDRFAEFKFTRTQVPL
                     VAKKLVDNGFHGKLVDVTNPCDVITSMYQKLTGLPKNHVMGTGTLLDSARMRACVGEAL
                     HVDSRSVVGFNLGEHGNSQFTAWSTVRVLGKRVLDLVDERHLDLTDMEERARQGGYMVY
                     KGKKYTNYGVATAAVRLTNALLSDARTEMPVSNYREEYGTYLSYPAVVGRDGVVEQLHL
                     DLTAAEKEKLATSAKYIKDRLSAEEQRAAQQDA"
     CDS             2358..5795
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090:acetyl-CoA carboxylase biotin carboxylase (Score:
                     92; E-value: 5.7e-28)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg34_4"
                     /sec_met_domain="HMGL-like (E-value: 1.2e-36, bitscore:
                     116.3, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 9.1e-12, bitscore:
                     34.5, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VFKKVLVANRGEIATRIIRACHELGIKAVAVYAKEDEYSAHRFAA
                     DEAYQIGAGEHPLDAYLDIDEVIRVAKESGAEAVHPGYGFLAENADLAQACIDNGLKFI
                     GPKPEHLRMFGDKLVAKRVAVEAGLQPIPGLSGDVKNVDQVKDFAHQYGYPIMVKAANG
                     GGGRGMRIINDDQQLTDEFDQAKDEALKAFGSDEMYVEKDVQHPKHIEVQVIADEHGHV
                     MHLFERDCSVQRRHQKVIEFALSVVLTPERRVEVCGLAVKLMKSVHYQNAATIEFLATP
                     DHFYFIEVNPRVQVEHTVTELITGIDIVKTQIRVAAGEDLHQDIGLPQQDDLKFHGAAI
                     QCRVTTEDPENNFMPDTGQVTTYDAPGGTGVRLDGNVYPGYKVTPYFDSLLVKCCTRGE
                     DFSDARIKMLRALEEFKIRGVKTNIPFMINVLKHPTFIAGKCSTTFIDENPDLFSFAHR
                     PDTPNQLLQYIGNVTVNGFAGVTKRTKLVLPDMQEPQAGQLTPNQHTTKTAKDILDKQG
                     ADAAMQYVKDQPRVLLTDTTMRDAHQSLFATRMRTHDMLPAMKVYDRAMPNLFSVESWG
                     GATFDVCYRFLGEDPWTRLRLLKKYMPHTLQQMLLRASNAVGYQNYPDNELKRFIEHSA
                     ATGVDVFRIFDSLNWIDQMERSITYVRETGKIAEGTMCFTGDFLSPHEHKYTLDYYMKL
                     AQSLVDAGAQIIGIKDMAGLLKPKAAYELVGSLKAKFDVPVHLHTHDTTGNGVPTYVAA
                     TNAGVDVVDVAMSSMAGTTSQPSLATFYYALEGDKRQPDLNMHNVAVLNRYWSNVRPLY
                     NDFSNGVNAPQPDLYQTEMPGGQYSNLKQQAQSLGINDFSLVEEKYREVNQLLGDIIKV
                     TPSSKVVGDMAIFMIQNHLDKDNILTKGQRVDFPESVVNFFAGDLGQPYRGFPKDLQKV
                     VLKDHPAITVRPGSLAKPVDFAAVKQELAAKINQEPSEDDLQGYIMYPKVFTTYFRNHQ
                     RYGEVMDLDTTTYYQGMRPGEILHVKYGQGKEMIIKLDFVSAPDDDGDRFLFFELDGRI
                     LKIKVKDNSMKDKVVSVSKADPDKSNEIGMPLNGNVVKVNVAEGDQVKVGDVLVVTEAM
                     KMESAVKAPFTGKVTKVYAKVGDALKSQDLLLTLTEDA"
     CDS             5810..6568
                     /locus_tag="ctg34_5"
                     /transl_table=11
                     /translation="MMYEFPRLTAHHIQTTDQPVVTSTNEMAKERLKVKDQPFLISARQ
                     QTAGHGKTSRKFYSPAGSGAYFTLALPFSYLAKSAGQVTVTAAVAAYEVLSKQFTVPIT
                     IKWVNDLYCERKKVVGILAEMEMTANNQPRGIVVGWGINLAAPTAPLPPALQLRAGWLG
                     TTSIDDHQRLQIVDAVAAHFLDLLANASWKHILQVYQAHQYLINKLLLVDTGAERVRGY
                     FDHITDDGWLCVQTDNGPRAFMTGTVRELV"
     CDS             6781..7158
                     /locus_tag="ctg34_6"
                     /transl_table=11
                     /translation="MTNDINFWTGIKDPYLKPDKPFLTEDKELKIIHLIQSYPMHCPLC
                     GQLMRRNGFRKRPVTIKILTPAGKPAVLKIKKQQYLCPPSPQCPKRVTKVAEIQGVNFA
                     CRIANVVKYHIVQELSESVRN"
     CDS             complement(7567..7950)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1144:thioesterase superfamily protein (Score: 100.2;
                     E-value: 1.1e-30)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg34_7"
                     /transl_table=11
                     /translation="MNLLENLGIHQDLVTKDRVELSMPVQAKHLQPYGIVHGGINTVLA
                     ETAASLGANANVAPGRIAVGVNVTTQHIRAIREGEIFVVATPDHVGRTLQTWQARLLVN
                     DRLTATATITLMNVPAPTNNHKH"
     CDS             7985..8806
                     /NRPS_PKS="Domain: ECH (18-261). E-value: 3.9e-63. Score:
                     204.7. Matches aSDomain: nrpspksdomains_ctg34_8_ECH.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023:enoyl-CoA hydratase (Score: 197.1; E-value:
                     4.6e-60)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg34_8"
                     /transl_table=11
                     /translation="MTSANWTPVKEYSEIIFERDDKIAKITMNRPEKHNAFTPVTVAEM
                     INAFNICRDDSTIGVIILTGAGDKAFSSGGDQSVRGNGGYVGPDHIARLNVLDLQHLIR
                     IIPKPVIAMVKGWSVGGGNVLQLVCDLTIAADNAMFGQTGPKVGSFDAGYGSGYLARVI
                     GHKRAKEVWFLNHFYTADEAYQMNWINKVAPLAEVESVTLDWCHEILKKSPTALRFIKA
                     AMNADTDGLAGLQQFAGDATMLYYTTDEGKEGRDAFNQKRDPDFDKFPKFP"
     aSDomain        8039..8767
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg34_8_ECH.1"
                     /evalue="3.90E-63"
                     /label="ctg34_8_ECH.1"
                     /locus_tag="ctg34_8"
                     /protein_end="261"
                     /protein_start="18"
                     /score="204.7"
                     /tool="antismash"
                     /translation="RDDKIAKITMNRPEKHNAFTPVTVAEMINAFNICRDDSTIGVIIL
                     TGAGDKAFSSGGDQSVRGNGGYVGPDHIARLNVLDLQHLIRIIPKPVIAMVKGWSVGGG
                     NVLQLVCDLTIAADNAMFGQTGPKVGSFDAGYGSGYLARVIGHKRAKEVWFLNHFYTAD
                     EAYQMNWINKVAPLAEVESVTLDWCHEILKKSPTALRFIKAAMNADTDGLAGLQQFAGD
                     ATMLYYTTDEGKEGRDAFNQK"
     CDS             8816..10240
                     /NRPS_PKS="Domain: AMP-binding (8-379). E-value: 2.2e-71.
                     Score: 232.3. Matches aSDomain:
                     nrpspksdomains_ctg34_9_AMP-binding.1"
                     /NRPS_PKS="type: NRPS-like protein"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     307.2; E-value: 2.9e-93)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg34_9"
                     /sec_met_domain="AMP-binding (E-value: 4.4e-76, bitscore:
                     245.6, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEIPNWLLKQASLNPNRVAVNDGTTAYTFAQLVPLVAHRAGQIQA
                     QTDQPRVGVMTHNNLAGYLAALGVLAADKTIVWLNWRLAPEELSRQIGDAGLDLVLVDD
                     QLADRYYGGHRVLCSELTAGTAPAAVLTPTVDLDAVASIMYTSGTTGQPKGVLQTYGNH
                     LASAISSSLNLGVLPNDLWLCVAPIFHISGFSILMRGLIYGMGVRLVNHFDAQVVNQIL
                     EDEPVTIISAVPYMLKKMLEDVQANDHCYSSAFRLVLLGGGTIDRATLNACEESGLPIV
                     QCYGMTETCSQFVALSAEEAPYHLGSVGKPLFTTQLRLVGEHHEIEIQTPALTPGYLNQ
                     PAKFAAKHDGDWYRTGDVGHFDEDGFLYVDGRLDEMIISGGENIFPAEVENVLRQYPGI
                     QEIAVVGRNDQQWGAVPVAVVVSKQPVDFQQLEAFGREHLAHYKVPKVYLQTDALPKNA
                     SGKVQKFRLQDLVANA"
     aSDomain        8840..9952
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg34_9_AMP-binding.1"
                     /evalue="2.20E-71"
                     /label="ctg34_9_AMP-binding.1"
                     /locus_tag="ctg34_9"
                     /protein_end="379"
                     /protein_start="8"
                     /score="232.3"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="KQASLNPNRVAVNDGTTAYTFAQLVPLVAHRAGQIQAQTDQPRVG
                     VMTHNNLAGYLAALGVLAADKTIVWLNWRLAPEELSRQIGDAGLDLVLVDDQLADRYYG
                     GHRVLCSELTAGTAPAAVLTPTVDLDAVASIMYTSGTTGQPKGVLQTYGNHLASAISSS
                     LNLGVLPNDLWLCVAPIFHISGFSILMRGLIYGMGVRLVNHFDAQVVNQILEDEPVTII
                     SAVPYMLKKMLEDVQANDHCYSSAFRLVLLGGGTIDRATLNACEESGLPIVQCYGMTET
                     CSQFVALSAEEAPYHLGSVGKPLFTTQLRLVGEHHEIEIQTPALTPGYLNQPAKFAAKH
                     DGDWYRTGDVGHFDEDGFLYVDGRLDEMIIS"
     aSModule        8840..9952
                     /domains="nrpspksdomains_ctg34_9_AMP-binding.1"
                     /incomplete
                     /locus_tags="ctg34_9"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       9236..9286
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg34_9_0001"
                     /evalue="4.30E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg34_9"
                     /protein_end="157"
                     /protein_start="140"
                     /score="22.4"
                     /tool="antismash"
                     /translation="ASIMYTSGTTGQPKGVL"
     CDS             10291..11481
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 230.9; E-value: 3.3e-70)"
                     /gene_kind="transport"
                     /locus_tag="ctg34_10"
                     /transl_table=11
                     /translation="MDAKPNRRALSLGSFVILYLGYMLLFADRTVLNLSLAAIGKDFSV
                     SPAALGATSSVFFLGYTIMQIPGGWLTDRFSSRKVIIATLAFWSVMTIFTGLAWSLAAL
                     LVIRFLFGIAEGPYPPAAMKQVAQDFPVNKRAQLTAALISSNYAGAALAPFIIVPIIAA
                     TGWRSAFFWLGGFGLLLMVSYLFFRGHGGGQTVTKQERQKINWKEIDPRVWAFVVIGLA
                     LNIITKGMETWMPVYFLNARHINLANLAWLVPLPTIAGGIAALISGYVMVHIFKNHERL
                     MIILASFLTVLTMFGLYKSTSLVWLVIFQMATYFVKSLAFTGIFSYAAQLFPQKTYGSQ
                     IGTINFGGQLGGFFGPLLIGWIVQLSGSYDTAFFGLVISALVAGVASLFIGNLKAK"
     CDS             11712..11858
                     /locus_tag="ctg34_11"
                     /transl_table=11
                     /translation="MKGFAMLGPNKTGFIEKEDPKVGSRDALVRPLAVAPCTSDIHTVF
                     EDA"
     CDS             11873..12781
                     /NRPS_PKS="Domain: PKS_ER (2-209). E-value: 3e-12. Score:
                     38.0. Matches aSDomain: nrpspksdomains_ctg34_12_PKS_ER.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040:alcohol dehydrogenase (Score: 198.5; E-value:
                     2.2e-60)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg34_12"
                     /transl_table=11
                     /translation="MILGHEACGVVVEVGEDVKDFKPGDRVLVPAITPNWSDVYSQAGY
                     ATDSDGMLGGWKFSNIKDGVFATRFHVNDADGNLAHLPDEIDPAEACMLSDMIPTGLHA
                     SEMAGVTFGDDVAVIGIGPVGLMALRGAVLHGAGRVFAVGSREKTVEVAKKYGATDIID
                     YHNGRISDQILEATGGQGVDKVLIAGGNAKDTFEEAVRMLKPGGSIGNVNYLNGHDDVV
                     FNAGDWGVGMGHKTIHGGLMPGGRLRMEKLAVLVVNGRIDPSLMITHRFEGFEKIPDAI
                     ELMHHKSADLIKPVVICNDID"
     CDS_motif       11879..11917
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg34_12_0001"
                     /evalue="6.00E-03"
                     /label="PKSI-ER_m2"
                     /locus_tag="ctg34_12"
                     /protein_end="15"
                     /protein_start="2"
                     /score="9.7"
                     /tool="antismash"
                     /translation="LGHEACGVVVEVG"
     aSDomain        11879..12499
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg34_12_PKS_ER.1"
                     /evalue="3.00E-12"
                     /label="ctg34_12_PKS_ER.1"
                     /locus_tag="ctg34_12"
                     /protein_end="209"
                     /protein_start="2"
                     /score="38.0"
                     /tool="antismash"
                     /translation="LGHEACGVVVEVGEDVKDFKPGDRVLVPAITPNWSDVYSQAGYAT
                     DSDGMLGGWKFSNIKDGVFATRFHVNDADGNLAHLPDEIDPAEACMLSDMIPTGLHASE
                     MAGVTFGDDVAVIGIGPVGLMALRGAVLHGAGRVFAVGSREKTVEVAKKYGATDIIDYH
                     NGRISDQILEATGGQGVDKVLIAGGNAKDTFEEAVRMLKPGGSI"
     aSModule        11879..12499
                     /domains="nrpspksdomains_ctg34_12_PKS_ER.1"
                     /incomplete
                     /locus_tags="ctg34_12"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       12278..12304
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg34_12_0002"
                     /evalue="5.30E+00"
                     /label="PKSI-ER_m2"
                     /locus_tag="ctg34_12"
                     /protein_end="144"
                     /protein_start="135"
                     /score="0.9"
                     /tool="antismash"
                     /translation="GAGRVFAVG"
ORIGIN
        1 gtacttaaac atgaccgttt accacgggat tgaaaaagat gacaattcag aagaagccgg
       61 tatgcttaag cttgtgaaat gataaattcg cggaatttaa tttacaccaa cattttggac
      121 ttgacctaag tttatctagc gggatgccat taccatatga tatcgaatcc gttatattgt
      181 atacgataca atctttttca ggtctcacat cattttcttg gtattcatcg tcaacatcca
      241 gaaagaaaat cttcttggac gttccgtctt taaacgtaat ggtcacacaa gtccgttcat
      301 attcccttag gaggtcatat atttcagtat gtgtgtcgat caccatcttt attcactccc
      361 cagtactact taatattctg tcacagaatg gttgattttt aattgccttc catgcattcg
      421 tattggctga gatagcctga cgcattgcct gcatggaatt agccgcctgg acagtatcaa
      481 cagtgatccg ggtcgccatt tcgttttgaa ctttagctat ttttacctcc tttctgcata
      541 ataaaagcca gctatttaag ctggctccgc cgttgattaa ttaactgaaa cttgaaagct
      601 gataacctcg cctgtttgac atggttatca gctttcaagt ttcagttata cagaataagg
      661 ttggtgcttt attagggata tgtttgagga gagatcattt aataccagca agttaggcgt
      721 cttgttgagc tgcccgttgt tcttctgcag aaaggcgatc cttgatgtat ttggcagagg
      781 tagcgagctt ttctttttca gcagcggtaa ggtccaggtg aagttgttcc accaccccgt
      841 cacgaccaac gactgcgggg taggagaggt acgttccgta ttcttcacgg taatttgaaa
      901 ctggcatttc agtccgggca tcacttagta gggcattggt aagccggact gcggcagtag
      961 caacaccgta gttggtatac ttctttccct tatagaccat gtagcctcct tgccgtgcgc
     1021 gttcttccat gtcggtaagg tcgaggtgcc gttcatccac cagatctagt actcgtttgc
     1081 cgagaacccg gactgttgac caggcagtaa attgggagtt accgtgttca ccaagattga
     1141 agccgaccac ggatcgtgag tcaacatgga gggcttcccc aacacatgcg cgcattcgtg
     1201 cggagtctag cagggtcccc gtacccatca cgtgattctt tggtagcccc gtgagcttct
     1261 gatacattga agtgatgacg tcacagggat tggtaacgtc gacaagtttg ccatgaaaac
     1321 cgttatcaac gagtttctta gcgaccaatg gaacctgagt ccgggtaaat ttaaattctg
     1381 caaagcggtc gtgatcgggt gtgtccacca gcttagactt tcccagagta gagattacaa
     1441 cgtcacagtc agctaattgt gaatcatcat taacggttaa gtttgtgtgg aacgggagat
     1501 tcgccatggc gtcacggagg tcaagcgcat cggcacggac ctttgcttcg ttagtatcat
     1561 agagggctaa atcatcagtg aatccaccag caacgagata atgggcgaca gttgcgccaa
     1621 cgtgccccat tccaactact gctactttcc ttgtcataat aaaacttcct ttcgattatc
     1681 gtattgttgc ctttaatctt actaatgtca gaaatatcac tgtctgccat gatcaccacc
     1741 acctttaata tcaaaacaaa aagcgtcctt tctagctctt gataaatcta agaactaaaa
     1801 aggacgcttg tgcgtggtac cacctttctt tacgacataa tgtcgcctca accaaccgcc
     1861 acaaataatg tggtattagc cggcacggta atgggtgcta ccaatacgct ctactaggga
     1921 atccgttcgg cgtacgactc acgagtgatt agtaggtgcg gcctctcact ggttcacacc
     1981 acccaccagc tctcttgctt cggcctcatc gctgtttctc gctcaacgtc tttaacttgt
     2041 ttcaattgat tgttaagtac tatatcacta ggcagatagg gaagtcaaga taaaaattaa
     2101 aaaaagatga gaaaagatgg gtgcaaaggc agataattta tagtataaat tcgtttgata
     2161 gcgggcattt cttgaggaaa aattattgac acgttagctt agattgatta tagtttgttt
     2221 taaaatttga ttagaaaaat gaggaggtga gtgcaatggt tggtaatatt aatatttcta
     2281 caaatacagc caccctcacc gccaatagta atgacgtgat gggcgtgaag gattaataaa
     2341 aaggatggtg gataattgtg tttaaaaaag ttttagttgc taaccgtggt gaaattgcta
     2401 cacggattat tcgcgcctgt catgagctgg gaatcaaagc cgtcgcagtt tatgctaagg
     2461 aggatgagta tagtgcgcac cgctttgctg ctgatgaggc gtaccaaatc ggggctggtg
     2521 aacatccgct tgatgcttac ctggatattg atgaagtaat tcgggtggcc aaagaaagcg
     2581 gggcagaagc tgttcaccct ggttatggct tcctggcaga aaacgctgac cttgcgcagg
     2641 cctgtattga taatggatta aagtttattg gacctaagcc ggaacacctt cgtatgtttg
     2701 gggataagtt ggttgctaaa cgtgtggccg ttgaggcagg gctgcaacca attcccggtt
     2761 tatcggggga tgttaaaaat gttgaccagg taaaggattt tgctcaccaa tatggttacc
     2821 cgatcatggt taaggctgct aatggtggtg gcggtcgggg gatgcggatc atcaatgacg
     2881 accagcaact caccgacgag tttgatcagg cgaaggatga ggcgctgaag gcgtttggat
     2941 cggatgagat gtatgtcgaa aaggacgtcc aacacccgaa gcatattgaa gtgcaggtaa
     3001 ttgctgatga gcacgggcat gtgatgcacc tctttgaacg tgactgctct gtccagcgcc
     3061 gccaccagaa ggttattgaa tttgcactta gcgttgtctt gacccctgag cggcgggtcg
     3121 aagtttgtgg cctggccgtc aagctgatga agagtgttca ctaccagaat gcggcgacga
     3181 tcgaattctt ggcgaccccg gatcattttt acttcattga ggttaatccc cgggtgcagg
     3241 ttgaacacac cgttaccgag ttgattactg ggattgatat tgttaagacc cagattcggg
     3301 ttgcggccgg tgaagatctt catcaagata ttggccttcc ccagcaagac gatctcaagt
     3361 tccacggggc agccattcag tgccgggtca caacagaaga tcccgagaat aactttatgc
     3421 cagatacggg acaggttacg acctatgatg cgccaggggg aaccggtgtc cggcttgacg
     3481 ggaacgtcta tcccggctat aaggtcactc cttactttga ttccttgctc gttaagtgtt
     3541 gtacccgggg tgaagacttc agtgatgccc ggattaagat gctgcgggcg cttgaagaat
     3601 tcaagattcg gggagtcaaa actaatattc ccttcatgat caacgtgtta aagcatccca
     3661 cgtttattgc cggaaaatgc tcgacaacgt ttatcgacga gaatcccgac ctctttagct
     3721 ttgcgcaccg gcccgatacg cctaaccagt tgctccaata tattggcaat gttaccgtca
     3781 atggctttgc aggggtaacc aagcggacca aacttgtttt gcctgacatg caagaaccac
     3841 aagcaggcca acttacacct aaccagcata caacaaaaac agcaaaggac atcctggata
     3901 aacagggagc cgatgcggcg atgcagtatg ttaaggacca gccgagggta ctactgactg
     3961 ataccacaat gcgtgatgct caccaaagcc tttttgccac tcggatgcgg acgcacgata
     4021 tgttgcccgc aatgaaggtt tacgaccggg cgatgcctaa cctcttttct gttgaaagct
     4081 ggggcggggc aacctttgac gtgtgctacc ggttccttgg tgaagacccg tggacccgat
     4141 tacgattatt gaagaagtac atgccacata ctctccagca gatgttgttg cgggcgtcga
     4201 acgcggtcgg ttaccagaat tatccggata atgaactgaa gcggttcatt gagcacagtg
     4261 ccgcaaccgg ggtggatgtt ttccggatct ttgactccct caactggatt gaccagatgg
     4321 aacgtagcat tacatatgtt cgggaaaccg gcaaaatcgc cgaaggaaca atgtgcttta
     4381 ccggcgactt ccttagtcct cacgagcaca agtacaccct agattattac atgaagttgg
     4441 cacagtcatt agtcgacgcg ggagcgcaga ttattggtat taaggatatg gccggcctct
     4501 tgaaaccaaa ggccgcttac gaactagtcg gtagtttgaa ggctaagttt gatgttcctg
     4561 ttcacctcca cactcatgac acaacgggta atggagttcc aacctacgtt gccgccacaa
     4621 atgcgggtgt tgacgtggtg gacgtggcga tgtcttcaat ggcggggaca accagtcagc
     4681 ctagtttagc caccttttac tacgcgctag aaggagataa acgccaaccg gaccttaata
     4741 tgcataacgt ggcggtctta aaccggtact ggtccaatgt ccggccgctt tacaacgact
     4801 tcagcaacgg ggtcaacgca ccgcaaccag acctatacca gacggaaatg ccaggtggcc
     4861 agtactcgaa cctgaagcaa caggcccagt cactaggaat caatgatttt agcctggtgg
     4921 aagaaaaata ccgggaggtc aatcagttgc tcggtgacat catcaaggtg acgccaagct
     4981 cgaaggtggt tggcgacatg gcaatcttca tgatccaaaa ccaccttgat aaagacaata
     5041 tcctgacaaa ggggcaacga gtcgactttc cagaatcagt ggttaacttc tttgctggcg
     5101 accttggtca accatatagg ggcttcccca aggacctaca gaaggttgtc ttgaaggacc
     5161 atcctgcaat cacggttcgg cccgggagcc ttgctaaacc ggttgatttt gccgccgtta
     5221 agcaggaact ggccgcaaag atcaaccagg aaccgagcga ggacgacctg cagggttaca
     5281 tcatgtatcc gaaagtcttt accacttact tccgcaacca tcagcggtac ggtgaagtga
     5341 tggaccttga taccacgacc tactatcaag gtatgcgtcc tggtgaaatt ttgcatgtta
     5401 agtatggtca gggaaaagaa atgattataa aactcgactt tgtttcagca ccagatgatg
     5461 acggtgatcg cttcctcttc tttgaactgg acgggcggat ccttaaaata aaagttaagg
     5521 acaatagcat gaaggacaag gttgtcagtg tttcaaaggc tgatcccgat aagagtaatg
     5581 agatcgggat gccgttgaac gggaacgtgg tcaaggttaa cgtagcagaa ggtgaccagg
     5641 tcaaggttgg tgacgttctg gttgttactg aggcgatgaa gatggaatca gcagttaaag
     5701 cgccatttac tggtaaggtg acgaaagtat acgctaaggt tggcgatgcg ttaaagagtc
     5761 aggacctctt actaacattg actgaggatg cttgataagg agagtagcaa tgatgtacga
     5821 atttcctaga ctgacagcac atcatatcca gacaaccgat cagccagtgg tcacttcgac
     5881 taacgaaatg gcaaaggaac ggttaaaggt gaaagatcag ccctttctca tctccgcccg
     5941 gcagcaaacg gcaggccacg gaaagaccag ccggaagttt tattcacccg cgggaagtgg
     6001 ggcctacttc acccttgcct taccctttag ctacctggca aaaagtgctg gtcaggtaac
     6061 ggtgactgcc gcggtcgctg cttatgaagt cctcagcaag caattcactg ttcccattac
     6121 tattaaatgg gtgaacgacc tgtactgtga gcgaaagaag gtggtgggga ttcttgctga
     6181 aatggaaatg accgcgaata atcagccgcg gggaatagtg gtcggctggg ggattaacct
     6241 ggcggcacca actgctccct tgccgccagc acttcagtta cgtgcgggat ggctcggcac
     6301 cacctcaatt gatgaccatc aacggctaca aatcgttgat gcagtcgctg cgcacttcct
     6361 tgacctgtta gcaaacgcgt cctggaaaca catcctgcag gtttaccagg ctcatcaata
     6421 ccttattaac aagctgctcc tcgttgatac aggagcggaa cgtgttaggg gatactttga
     6481 ccatattacg gatgatggct ggttatgtgt gcagacagat aacgggcccc gcgcattcat
     6541 gacggggacg gttcgggaac tggtttagta attaaaaaag cagtccttct tggacaaacg
     6601 cggacgtgtt ttgaccgcag ttatccttga aggttctatg atattcggta aggataagat
     6661 gatttcttgt ctttaccgtt ttttgttact tgctgtacca ttgatttaaa aataaaaaaa
     6721 gacaactgtc ttaagttatc cccataacca ctcagttgtc ttagaaagga tatattcctc
     6781 atgactaatg atatcaattt ttggactgga atcaaggatc cttacttaaa acctgacaaa
     6841 ccatttttaa ctgaagataa agaactaaag attatccatt taattcagtc ttatcccatg
     6901 cactgtccgc tttgcggcca gttgatgcgt cgtaatggct tccgtaagcg gcccgtaacg
     6961 atcaaaatcc ttacaccggc tggaaaacca gctgtcttaa aaatcaagaa acaacagtat
     7021 ctctgtccac catcgcccca atgccccaag cgagttacca aggttgccga gattcaagga
     7081 gttaattttg cctgtcgaat tgcgaatgtc gttaaatacc atattgttca ggaactcagt
     7141 gagagcgtac gtaattaagt cttgaacatc tgtattgtca tcctcggagg gcctttgagg
     7201 cttctttaat catcaaacga tatctttaca taatgtaaat ttacagaagt aagtctaatt
     7261 agcgccgtta gagtaattac ctgaaaagag cggcgatgca aaagacgacc agtttcaatt
     7321 ccacccacca tttcctcata tctggtcctc ccctcgataa attatgtgtg cttttgcgta
     7381 ctggttgcaa cactaataca aaatcggggc caacttaaat cgactgcgta gtggcgcccc
     7441 tttcataaca gttagccgac gacttctcga ttgatttaca taatataaaa ttaaaaaatg
     7501 tgatttaggt aatcccccaa tggtcacccg gcaactttct aagcataata gtagccaatt
     7561 tgtgaattaa tgtttatgat tgttggttgg tgctgggacg ttcatcaggg tgatggttgc
     7621 ggtagccgtt aatcggtcgt taaccagtag ccgggcttgc caggtctgaa gtgtgcgacc
     7681 aacgtgatca ggggttgcaa ccacaaaaat ctccccttcc cgtatcgcac ggatatgttg
     7741 tgtggtaaca ttgaccccga ccgcgattcg ccccggcgct acgttggcgt tagcccctag
     7801 ggaggccgcg gtttccgcca gcacggtgtt aattccgccg tgaacgatcc cgtacggttg
     7861 caagtgcttt gcttggaccg gcatggagag ttcaacgcgg tctttggtca ccaagtcctg
     7921 gtgaatgcct aagttttcaa gtaaattcat ttttgtacct ctggattttg taaaggagtt
     7981 tgttatgacg agtgctaact ggacccccgt taaggagtat tccgaaatta tttttgaacg
     8041 cgacgataag attgccaaga ttacaatgaa ccggccggaa aagcacaatg ccttcacccc
     8101 ggtaacggtc gccgaaatga tcaacgcgtt taacatctgt cgtgatgata gcacaattgg
     8161 cgtgattatt cttaccggag ccggcgataa ggccttttct tccggtggtg accaatccgt
     8221 gcggggtaac gggggttacg tgggccccga ccacatcgcc cggctcaacg ttttggacct
     8281 ccaacacttg attcggatca tccccaagcc ggtgattgcc atggtcaagg gctggtcagt
     8341 cgggggcggg aacgtcttac aactggtttg tgacctgacg atcgccgccg ataacgccat
     8401 gtttgggcaa acggggccga aggtgggttc ctttgacgcc ggttatggct cgggttacct
     8461 agcccgggtg atcggccaca agcgggccaa ggaagtttgg ttcttaaacc acttctacac
     8521 ggctgacgaa gcttaccaaa tgaactggat taacaaggtg gcgcccctag ctgaggtcga
     8581 atcagttact ttagactggt gtcatgaaat cttaaagaag tcaccgaccg cccttcgctt
     8641 cattaaggcg gccatgaacg ccgatacaga tggtttagcg gggcttcaac aatttgccgg
     8701 tgacgccacg atgctttact acacgactga cgaaggaaag gaagggcgcg acgcctttaa
     8761 ccaaaagcgc gaccccgact tcgataagtt cccgaagttc ccgtaggagg ccgtcatgga
     8821 gattccaaat tggctcctca aacaggcttc gctaaaccct aaccgggtgg cggttaacga
     8881 cggtaccacc gcctacacct ttgcccagct ggttcccctg gtcgcccacc gtgctggcca
     8941 gattcaagcg cagacggacc agccccgggt tggggtgatg acccacaata acctggctgg
     9001 ttacttagcc gccctggggg tcttagccgc cgacaagacc atcgtttggc taaattggcg
     9061 ccttgcccct gaagaactga gccgccaaat cggcgacgcg gggctcgacc tagtcttagt
     9121 cgatgaccaa ctagccgacc gctattacgg tgggcaccgg gtcctctgtt cggaattgac
     9181 agccggcact gccccggcgg cagtgttgac gccgacggtt gacctagacg ccgtggcctc
     9241 gatcatgtac acctcgggaa ccaccggtca gccaaagggc gtcttgcaaa cctacggcaa
     9301 ccacttggcc tccgccattt cgtcatcttt gaacctcggg gtgttgccaa acgacctctg
     9361 gttgtgcgtc gcccccatct tccacatttc gggcttttca attctaatgc ggggcctgat
     9421 ttacgggatg ggcgttcgcc tagtcaacca tttcgatgcg caagtggtca accaaatcct
     9481 ggaggacgaa ccggttacga tcatttcggc cgttccctac atgctaaaga agatgctcga
     9541 agacgtccaa gcaaatgacc actgttactc atcggccttt cgcctggtgc tactcggcgg
     9601 tgggacgatt gaccgggcga cccttaacgc ctgcgaagaa agtgggctgc cgattgtcca
     9661 gtgttacggg atgaccgaaa cttgctcgca gttcgttgcc ctctcggctg aagaggcgcc
     9721 ttaccacctt ggttcggtcg gtaagcccct gtttaccacc cagctgcgtt tggtgggtga
     9781 gcatcacgaa atcgagatcc agaccccggc cttaaccccg ggttacttaa accaaccggc
     9841 caagtttgcg gctaagcacg atggcgactg gtaccgaacc ggcgacgtcg gccactttga
     9901 tgaagacggt ttcttgtacg tcgacggacg gttagatgaa atgatcatct ccgggggcga
     9961 aaacattttc cccgccgagg tggaaaacgt cttgcgccag tacccaggca tccaagaaat
    10021 tgccgtggtc ggccgtaatg atcaacagtg gggcgccgtt cccgtggccg tggtcgtcag
    10081 caaacaaccc gtcgactttc agcagttgga ggccttcggg cgtgaacacc tggcccacta
    10141 taaggtaccc aaggtctact tgcaaacaga cgccctaccg aaaaacgcca gcggcaaggt
    10201 ccaaaagttt cgcttacaag acctggtcgc taacgcttag tcatgccaca acagaataat
    10261 caattgagaa aagaaagata caaataaatg atggatgcaa aacccaaccg ccgggcgctg
    10321 tcgctcggtt cctttgtgat tttatacctt ggttacatgc tcttattcgc cgaccggacc
    10381 gtgcttaact tatcgttggc cgcgatcggc aaggatttct ccgttagccc ggccgcactg
    10441 ggggcgacta gttccgtctt cttcttgggc tacacgatca tgcaaatccc ggggggctgg
    10501 ctgaccgacc gcttctcttc ccgtaaggtg atcatcgcca ccctcgcctt ttggtcggtg
    10561 atgacgatct ttaccgggct ggcctggtcc ttagccgccc tcttggtaat tcggttcctg
    10621 tttgggatcg ccgagggccc ttacccaccg gccgccatga agcaagtcgc ccaggacttc
    10681 ccggtcaaca agcgtgccca actgaccgcc gccttaattt cctctaacta cgccggcgcg
    10741 gccctggccc ctttcatcat cgtgccaatc atcgccgcta ccggttggcg ctcggccttc
    10801 ttctggttgg ggggctttgg cctactcttg atggtcagct acctcttctt ccgcggtcac
    10861 ggcggtggac aaacggtaac gaaacaagaa cggcaaaaga taaactggaa ggaaatcgac
    10921 ccgcgggtct gggccttcgt ggtgatcggg ctggccttaa acattatcac caaggggatg
    10981 gaaacctgga tgccggttta cttcttaaac gcccgccaca tcaacttagc caacttggct
    11041 tggttagttc ccctaccgac gattgccggg gggattgcgg ccttgatttc cggttacgta
    11101 atggtgcaca tctttaaaaa tcacgaacgc ctgatgatta tcctggcctc ctttttaacg
    11161 gtcctgacca tgtttggact ctacaagtcc accagcctgg tttggttagt gatcttccaa
    11221 atggccacct acttcgtcaa gtcgctagcc ttcaccggga tcttctccta cgcggcccaa
    11281 ctcttcccgc aaaagactta tggctcccag atcgggacga ttaactttgg tggccaactc
    11341 gggggcttct tcggtcccct cttaatcggc tggatcgttc agttgagcgg ttcatacgac
    11401 acggccttct tcggcctggt catctccgcc ttggtggccg gggtggcgtc cctcttcatt
    11461 gggaatttaa aagctaaata atccgctaat tatagaatga ttaatgactg tggtgacctc
    11521 gtacgggatt atcacagtca ttttatttat ttcaaatcaa tttcttaact atcataatcc
    11581 ctgttatttt aaccctttca gagaatgtgg acgctttctt taaaattaat taaactcaca
    11641 tatgaagact tggttataac atgatttatg ttagaatgac ggcaactaat caagaaaggt
    11701 ggtagttatg aatgaaaggt tttgcaatgc tgggccccaa caagacgggc tttattgaaa
    11761 aagaagatcc caaggtgggc agccgtgacg ccctggtacg tcccctagcc gttgccccgt
    11821 gtacttctga catccacacc gtgtttgaag atgcctaggg ccacgggaga atatgattct
    11881 cggccacgaa gcctgcgggg tggttgtgga agtcggtgaa gacgtcaagg actttaaacc
    11941 gggtgaccgg gtactcgttc cggcgatcac gccaaactgg tctgacgttt actcccaagc
    12001 tggctacgcc actgattccg acgggatgct gggcggctgg aagttctcta atatcaagga
    12061 cggggtcttc gccactcgtt tccacgttaa cgacgccgac gggaacctgg ctcacctacc
    12121 ggatgaaatt gacccggccg aggcctgcat gctttccgac atgatcccaa ctggcctcca
    12181 cgcttccgaa atggcgggcg tgacctttgg ggatgacgtc gccgtgattg ggatcggccc
    12241 ggttggcttg atggccctgc gcggggcggt gctccacggg gctggccgcg tctttgcggt
    12301 tggttcacgg gaaaagacgg tcgaagtggc taaaaagtac ggcgcaaccg acatcattga
    12361 ctaccacaac ggccggattt ccgaccaaat cctggaagcc actggtggcc aaggggtcga
    12421 caaggtcctg atcgccggtg ggaacgccaa ggacaccttt gaagaagccg tccggatgct
    12481 caagccgggt ggctcaatcg ggaacgttaa ctacttaaac ggtcacgacg acgtggtctt
    12541 caacgccggt gactggggtg ttgggatggg tcacaagacc atccacggtg gcctgatgcc
    12601 tggtggccgc ctgcggatgg aaaagctggc cgtcctcgtg gtgaacggcc ggatcgatcc
    12661 atcactaatg atcacccatc gcttcgaagg cttcgagaag attccggacg ccatcgaact
    12721 gatgcaccac aagtcggcgg acttaatcaa gccggtcgta atttgcaacg atatcgacta
    12781 attaaaaggg agtggcaaat aacttgcttg gcaggtcgta tgactaagct aggggcggaa
    12841 cgcatcgttc ttcggccggc ttagacacta ggcctgtggt tattgaccac gttttctatc
    12901 taacatacgc aaagtcaacc accactgact aaagtcagta gcttgtgagc aagcaccctt
    12961 ctgatgagtg tttgaatcac aatttgcata gatacaccac tgcgaacagt tctacgaacc
    13021 gtttcgtctt acacggca
//
