LOCUS       c00116_JABWOT0..        6740 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JABWOT010000116.1 Streptococcus thermophilus strain CBC-S77
            3CBC_contig_69, whole genome shotgun sequence.
ACCESSION   JABWOT010000116
VERSION     JABWOT010000116
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 00:25:14
            Original ID  :: JABWOT010000116.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 6740
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..6740
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[268:3160](+)"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      269..3160
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     cand_cluster    1..6740
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..6740
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /tool="antismash"
     CDS             3..80
                     /locus_tag="ctg116_1"
                     /transl_table=11
                     /translation="KLAEKFFGNKDYIPTKDALKVPSKK"
     CDS             269..3160
                     /NRPS_PKS="Domain: AMP-binding (6-388). E-value: 6.9e-65.
                     Score: 210.9. Matches aSDomain:
                     nrpspksdomains_ctg116_2_AMP-binding.1"
                     /NRPS_PKS="type: NRPS-like protein"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     172.5; E-value: 2e-52)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg116_2"
                     /sec_met_domain="AMP-binding (E-value: 9.9e-65, bitscore:
                     206.7, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.5e-07, bitscore:
                     20.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTILKTFSDTVKQYPSKVAVMYSGGEFTFQEVDVMSNFIAKQLLL
                     NSDEETVPFYIEKNKYVLPVVLGIMKSGKIPLPITNSLEVKISLERISEVVFDVLISDR
                     DVKLENHSVTLLLLPKKLESYSEYQEVATTKENEIAHIICTSGTTGVPKKVFLTDDNID
                     WLVKEFYKIVKFTSESKFLFTTPYTFDVSLTEILAPVYTGGTLVCYDGGIQNIIRLGET
                     IEKKKITHLSLSPSFAETIIDISGPEVFQNLRALCLAGETFPSSLANRLRGLIQQGCRV
                     FNLYGPSETTIYATYYELKDRKYNTVPIGKPLPGVQLKIASQKENSKMAELLIGGNGVT
                     EGYRLQPELNKAKFKLIGSNRYYVTGDYVYYQGDNLVFSSRIDSQVQVNGIRIELDEVK
                     SIVDKLKSVKSSRVVFYKKKLVVFYEADLNIKEDIIRSLPSYLNPTVVKVESYYLNQNR
                     KLDVPKMLEIYYYKKQSQQGDDVRKNILDVLSKFERVDITDLDSLELVRFYLEIEDIFD
                     IEIKENDFYRLKSVDSIVDYIRNKSFFQERSTEPNDSFTKEHDLVNLEYNLTKMNYRYL
                     KNIITPSPTQKRLYKNNQNRVIGFNLALEEVTYLELNKLHHIIKYLSYKIDIFRLVVEK
                     EQTRFSIGIVNEGDYSPNIIVLNNLPTELELQGILDNIEVIPIPIIVVGTRDKKVRFYF
                     PYHSIDASSLNKLGDTVYQLYEKKIVIDEVPSSSLVAFSQFKREVLQNDVSGDVLARLP
                     KIKPAIEFEKLNDEVQCFQVSLPEDIKGDDVYLFTIYAISQCILSDYNLSAISGGLSLD
                     FRDYEQFDAYDLIGDIHKKIPFQVNRTETFEEFKNSHFKILEIYRTGIDYYEIAMLGND
                     MSAKEVQERLNNLSLSINFIGEAFRLKDTINNIIDVDFDKNFINVFVHERFAYAVIKSE
                     LLSNSVYDLMHKDSKFELKVIDKKRLENEETNR"
     aSDomain        287..1432
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg116_2_AMP-binding.1"
                     /evalue="6.90E-65"
                     /label="ctg116_2_AMP-binding.1"
                     /locus_tag="ctg116_2"
                     /protein_end="388"
                     /protein_start="6"
                     /score="210.9"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="FSDTVKQYPSKVAVMYSGGEFTFQEVDVMSNFIAKQLLLNSDEET
                     VPFYIEKNKYVLPVVLGIMKSGKIPLPITNSLEVKISLERISEVVFDVLISDRDVKLEN
                     HSVTLLLLPKKLESYSEYQEVATTKENEIAHIICTSGTTGVPKKVFLTDDNIDWLVKEF
                     YKIVKFTSESKFLFTTPYTFDVSLTEILAPVYTGGTLVCYDGGIQNIIRLGETIEKKKI
                     THLSLSPSFAETIIDISGPEVFQNLRALCLAGETFPSSLANRLRGLIQQGCRVFNLYGP
                     SETTIYATYYELKDRKYNTVPIGKPLPGVQLKIASQKENSKMAELLIGGNGVTEGYRLQ
                     PELNKAKFKLIGSNRYYVTGDYVYYQGDNLVFSSRIDSQVQV"
     aSModule        287..1432
                     /domains="nrpspksdomains_ctg116_2_AMP-binding.1"
                     /incomplete
                     /locus_tags="ctg116_2"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       686..742
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg116_2_0001"
                     /evalue="1.00E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg116_2"
                     /protein_end="158"
                     /protein_start="139"
                     /score="15.1"
                     /tool="antismash"
                     /translation="AHIICTSGTTGVPKKVFLT"
     CDS_motif       1259..1330
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg116_2_0002"
                     /evalue="2.80E-06"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg116_2"
                     /protein_end="354"
                     /protein_start="330"
                     /score="19.7"
                     /tool="antismash"
                     /translation="ELLIGGNGVTEGYRLQPELNKAKF"
     CDS_motif       1406..1462
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg116_2_0003"
                     /evalue="2.60E-06"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg116_2"
                     /protein_end="398"
                     /protein_start="379"
                     /score="20.0"
                     /tool="antismash"
                     /translation="SRIDSQVQVNGIRIELDEV"
     CDS_motif       2042..2089
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg116_2_0004"
                     /evalue="1.30E+01"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg116_2"
                     /protein_end="607"
                     /protein_start="591"
                     /score="-0.8"
                     /tool="antismash"
                     /translation="NNQNRVIGFNLALEEV"
     CDS             3157..4803
                     /locus_tag="ctg116_3"
                     /transl_table=11
                     /translation="MSIYKDIVEGYQLNNIQEKDKLNNVLVQLNEKDDQEMINRKNFIG
                     HFTASAFVISKDNRRLLMVHHNILKRYLQPGGHIDKNDRNPLDAAKRELFEETGIDSEI
                     LTYQCAEPLNSLIPFNVSVHKIPENKLKNERSHYHYDLQYLFYIENEVDVKIDSNESSS
                     YEWIQLDNVKDMDGYKEIIKKIEKLEAASQERFLSNMLKGASFEDISCITVQHIIPSTI
                     PIIMTLQKIFGHRLLVCAKPNSVDKMVWHKLENMGVRLTLASRDEYFNVDYLGIKSKTI
                     LLDIGGYFASIAQIPNLPIECIIEDTENGIQKYENVIDQIEYPLFSVARNPLKKNEDYL
                     VGADIVFGTDYILHQKNLLMQYMQVVCIGYGKIGYGICTKLRELGIRPKVLEKDSMRTI
                     QAVRDGCDILLEKDFKNIDLIFCATGSKSLDILDFRSIKDGTFLVSATSSDDEFNYSYL
                     LDEYEEIVETSLITRYESEDNYFYLLNQGTPTNFVVNSALGNYILLVQAAILYTAKKFI
                     EDREMAIAKQVNTLSDEDNYNIAKQWLEEFC"
     CDS             4829..6037
                     /gene_functions="transport (smcogs) SMCOG1020:major
                     facilitator transporter (Score: 278.7; E-value: 1.3e-84)"
                     /gene_kind="transport"
                     /locus_tag="ctg116_4"
                     /transl_table=11
                     /translation="LNKKEQQNTYLLVGSRIISRVGDIMFDFANNTFLSSVNVKSLMLV
                     GIYQTLENIISVIFNLFGGVLSDNFQRKRIIILTDILSGVLCLALSFISNQQWLIYAVV
                     ITNIILAFFSSFSGPAYKAFTKEVVEADNISKLNSLLESFITVVKVVVPLVSVSLYGLL
                     GLYGILRLDGITFIASGLLILFIRPILEESTGKQVFSLSKIFSDLFEGGRYLASQKEIL
                     YLVILSAIVNFFLAAYNLLLPYSNQMFPRVTVGLYGVFLGAEAVGGLIGASLSSILNKV
                     LKIKTMILYLGVSGVFLSLTPMVYCVFPSAYMLALYPALFNLFLTMFNLQFFSYIQKNV
                     DNVFLGRVFGIIFTVAILFMPIGTMTFTFLLSPKNIFNFVIVGLSIGGISLLFYRIFSK
                     RLR"
ORIGIN
        1 ctaagttggc tgaaaaattc tttggaaata aagattatat tccaactaaa gacgctttga
       61 aagttccaag taaaaaataa gaaaggctct ttgtcaactg tagtgggtga cgaaaagcct
      121 ttgtttatca tatgataaac aaaagaggga aatgatgaaa aaggtaaaat ttttgccaac
      181 tttgaaaatt gcttttgaaa ttcttattgt tgtgtgtgga taaattatga atgacagtgc
      241 ataatcaatc aaattaagga gaagagaaat gaccatatta aaaactttta gtgatacggt
      301 gaaacaatat ccttctaaag ttgctgttat gtatagcgga ggagagttta cttttcaaga
      361 agtagatgtg atgtctaatt ttattgctaa gcagctacta ctcaatagcg atgaagagac
      421 tgtacctttt tatatagaaa aaaataagta tgttttacca gttgttttgg ggataatgaa
      481 atcgggtaaa attccgttac ctataacaaa tagtcttgag gtcaaaatat cattagaacg
      541 tattagcgaa gttgtctttg acgtgttgat aagtgatagg gatgttaaac ttgaaaatca
      601 ttcagtaact cttttgctct tacccaaaaa attagaaagt tacagtgagt atcaagaagt
      661 agctacaact aaagagaatg aaattgcaca tattatctgt acttctggaa ctactggggt
      721 tcctaaaaaa gtatttttaa ctgatgataa catagattgg cttgtaaaag aattttataa
      781 aattgtgaag tttacttccg aatcaaaatt tttatttaca actccctata cttttgatgt
      841 ttcattaaca gagattttgg cacctgtata tacgggtggt actttggttt gttacgatgg
      901 tgggattcag aatattattc gactaggaga aacaattgag aaaaagaaga taactcattt
      961 atcattatct ccgtcttttg ctgaaactat tattgatatt agtgggccag aagtattcca
     1021 gaatttaaga gcgttgtgtc tagcaggtga gacatttcct agttcattag cgaataggtt
     1081 gagagggctt attcagcaag ggtgtcgagt atttaattta tatgggcctt cagaaacaac
     1141 aatttatgca acctactatg agttgaaaga tagaaaatat aatactgttc caattggtaa
     1201 gcctttgcct ggggttcaac taaagatagc ttctcaaaaa gagaattcta agatggcaga
     1261 acttctaatt ggtggtaatg gagtaacgga agggtataga ctacaacccg aattaaataa
     1321 agctaagttt aagttgatag gttcaaatag gtactatgta acgggggact acgtttatta
     1381 ccaaggagat aacttggtat ttagttcaag aatagatagc caagtccaag taaatggtat
     1441 tcgtattgaa ttagatgagg taaaatctat tgtagataaa cttaaatcag ttaaatcatc
     1501 acgagttgtt ttttataaga agaaacttgt cgtattttat gaagccgatt tgaatattaa
     1561 agaagatatt attagaagtt tacctagtta cttaaatccg acggtagtta aagttgagag
     1621 ttattatctc aatcagaata gaaagttgga tgttccaaaa atgcttgaga tatattatta
     1681 taaaaaacaa agtcaacaag gagatgatgt tagaaaaaat attttagatg tactatctaa
     1741 atttgaaaga gttgatatca cagatttgga ttcgttagaa ttagttagat tttatttaga
     1801 gattgaggat atctttgata ttgaaattaa agaaaatgat ttttataggc taaagagtgt
     1861 agattcgatt gtggactata ttagaaataa atcatttttt caagaacgtt caactgagcc
     1921 aaacgatagt tttactaaag aacatgactt ggttaattta gagtataatc tcacaaaaat
     1981 gaattatcgt tatttgaaaa atattattac tcctagcccg acacaaaaga gactttataa
     2041 aaacaatcaa aatcgtgtta ttggttttaa tttagcactg gaagaagtga cttatttaga
     2101 attgaataag ctgcaccata ttattaaata tttaagctat aaaattgata tatttagact
     2161 tgttgtcgaa aaggagcaaa ctcgatttag cataggtatt gtgaatgaag gagattactc
     2221 acctaatatt attgtactaa ataatttacc aacagagtta gaattacaag gaatattaga
     2281 taatatagaa gtgattccta ttccaattat tgtggtggga acaagagata aaaaagtaag
     2341 attttatttt ccatatcatt ctattgatgc atcatcatta aataaacttg gagatacagt
     2401 atatcaactg tacgaaaaaa agatagttat tgatgaagta cctagtagtt cactggttgc
     2461 tttttcgcag tttaaaaggg aggtgttaca gaatgatgtc tctggggatg ttcttgctag
     2521 attgccaaag ataaagcctg ctattgagtt tgagaaatta aatgatgaag ttcaatgttt
     2581 tcaagtttct ttaccagaag atattaaagg agacgatgta tatcttttta caatttatgc
     2641 tatctcacag tgtattttaa gcgactataa tctgtctgct atatctgggg gtctatcttt
     2701 ggattttaga gattatgaac agtttgatgc gtatgactta ataggagaca ttcacaagaa
     2761 aattccattc caagtaaatc gaactgaaac ttttgaggag tttaaaaact ctcatttcaa
     2821 aattttggag atctatcgta caggtattga ttactatgaa attgcaatgt taggaaatga
     2881 tatgagtgct aaagaagtgc aagaacgatt aaataatctg tctctatcaa taaatttcat
     2941 tggcgaagca tttaggttaa aagatactat taataatata attgatgttg attttgataa
     3001 aaattttatt aatgtatttg tacatgagcg atttgcatac gcagttataa aatctgagtt
     3061 attgagtaat agtgtttatg acttaatgca taaagatagc aaattcgagc taaaagtaat
     3121 tgataaaaaa cgactggaaa atgaggagac aaaccgatga gtatttataa agatatagta
     3181 gaggggtacc aactgaataa tattcaggaa aaggataaat tgaataacgt tttggtacag
     3241 cttaatgaaa aagatgatca agagatgata aatagaaaga atttcattgg gcattttaca
     3301 gcatcagcat ttgttatttc aaaagataac aggcgtttat tgatggttca ccataatatt
     3361 ttaaaaagat acctacagcc tggggggcat attgataaaa atgatagaaa cccgctagat
     3421 gcagcgaaac gtgagctgtt tgaggagact gggatagatt ctgaaatatt gacgtatcaa
     3481 tgtgcagaac cattgaatag cttgatacct tttaatgttt ctgtgcataa gataccagaa
     3541 aataaattga agaatgagcg ttcccactac cattatgact tgcaatattt attttatatt
     3601 gaaaatgagg ttgatgtgaa aattgacagc aacgaatcga gttcctatga gtggattcag
     3661 ctagataatg taaaggacat ggacggctat aaggaaatca ttaagaagat tgaaaaactt
     3721 gaagcagctt ctcaagaacg ttttttatct aatatgctga aaggtgcatc gtttgaagac
     3781 atatcatgta ttactgtaca acatattatt ccaagtacaa taccgattat catgacattg
     3841 caaaaaatat ttgggcatcg tttgttagtg tgtgctaaac caaactctgt tgataagatg
     3901 gtatggcaca agctagaaaa tatgggggta agattaacat tagcttcaag ggatgaatat
     3961 tttaatgtag attatctggg gataaagagt aaaacaattt tattagacat tggtgggtat
     4021 tttgcctcaa ttgctcagat tccaaactta cctatcgagt gtatcattga agatacagaa
     4081 aatgggattc aaaaatatga gaatgttatt gatcaaatag aatatccgtt attttctgtc
     4141 gctagaaatc ccctgaagaa gaatgaggat tacttagttg gtgcggatat tgtttttggg
     4201 acagattata tattacatca aaaaaattta ttaatgcaat atatgcaagt ggtttgtatt
     4261 ggatatggga aaatcggtta cggcatctgt accaaattaa gagaacttgg tattagaccg
     4321 aaggtgctgg aaaaagatag catgagaact attcaagcgg tacgtgatgg ttgcgacatt
     4381 ttgctagaaa aagatttcaa gaatattgat ttgatttttt gtgcgaccgg ttcaaaaagt
     4441 ctagatattt tagattttcg ctctatcaaa gatggaacct tcctagtctc tgcaacatct
     4501 agtgatgatg aatttaatta tagctattta ttggatgaat atgaagaaat agtcgaaact
     4561 tcattaatca ctagatatga aagtgaagac aactatttct atctgttaaa tcaaggaaca
     4621 ccaactaatt ttgtagtaaa ctccgctttg ggaaattata ttttattagt ccaggcagcc
     4681 attctatata cagctaagaa gtttattgaa gatagagaaa tggctatagc taagcaagta
     4741 aacactcttt cggatgagga taactataat attgcgaagc aatggttaga agagttctgc
     4801 taatgaacaa atatctgagg agtttatttt gaataaaaaa gaacaacaaa atacatattt
     4861 acttgtaggg agccgtatta tttctcgtgt tggagatatt atgtttgact ttgcgaataa
     4921 cactttttta tcgagtgtaa atgttaagtc acttatgtta gttggtattt atcagacatt
     4981 agaaaacatc atcagtgtga tttttaatct ttttggtggt gttctgtctg ataactttca
     5041 aagaaaacgg attatcattt taacagatat tttaagcgga gtattgtgtc ttgccttatc
     5101 ttttatttct aatcagcagt ggttgattta tgctgtggtt atcacaaaca ttatattagc
     5161 ttttttctca tcattttcag gccctgctta taaggctttt actaaagaag tggtggaagc
     5221 agataatatt tcaaaactaa actcattact agaatcgttt ataacggtag ttaaagtcgt
     5281 tgttcccctg gtatcggtat ctctatacgg tttactagga ttatatggta ttttacgtct
     5341 agatgggata acatttattg catctgggtt gcttattctc tttattcgtc ccatacttga
     5401 agaaagtact gggaaacagg tgttttcatt atcgaaaatc ttttcagatc tttttgaagg
     5461 aggaaggtat ctagctagtc aaaaggaaat tttgtacttg gttattttat ctgcgattgt
     5521 taatttcttt ttagcagctt ataatctgtt gttaccatat agcaatcaga tgttcccaag
     5581 agttaccgtt ggcttatacg gtgttttcct aggagcagaa gcagtaggtg gtcttattgg
     5641 agcgtcttta agcagtattc tcaataaagt tttgaaaata aaaacaatga ttttatatct
     5701 tggagtatca ggtgtttttc tatctttgac acctatggta tactgtgttt ttccaagtgc
     5761 ttatatgctt gcgttatatc ctgctttatt caacttgttt ttgactatgt tcaacttaca
     5821 gtttttttca tatatccaaa agaatgtgga taatgtcttt cttggtagag tttttgggat
     5881 tatttttact gttgcaattt tatttatgcc cattgggaca atgacattta cttttctttt
     5941 aagccctaaa aatatcttta attttgttat cgttggttta tctataggag gtatttcgct
     6001 tctcttttat aggattttta gcaaaagatt gaggtaaatt ttcagagtaa ttttagctcc
     6061 gatggcgtag taaaattgct tagtaaagtc acaatttata tacttgttag ggcaaccatt
     6121 acacacataa ggtaatcgtt ttagaagtgg gcgggcctca cattttgagt gttgattgat
     6181 tccttgatgg taaggtgttt acatactttt ttagagacag tagatgggtc gccgattagt
     6241 ttagaaatag ctctaaatgt cttgttcgtt tctcataaaa gtcagcgata ttgcagggat
     6301 tggtatgact agctgaagcg atgttgtgaa tgtacttgaa caagatttta ctggcatagg
     6361 gattccctcg tttagtgatg tgttccttag cgagaaagtt cccagattca tagtgtctca
     6421 ggtcaatgcc aataaaagcg ttgatttgat tggtatactg cgacgaatat ctcccaattc
     6481 gccaatgata gatgtcgctg tggtttctgc gatgccagga attgaccgta agatgtcata
     6541 ctctggtaaa ggctgagcta gagctaccat gtcgtttaag acaacccgtc tgcgttcaga
     6601 aagacgaagc aattcggctc tttgtcaaac aattgatatt tttaggtgat agtattttct
     6661 tatcactttg attatgttta agtattagtt aagcttagtg aattctgtta caataaaaac
     6721 aatcaatctc aaaggagagt
//
