LOCUS       c00126_JABWOT0..       14231 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JABWOT010000126.1 Streptococcus thermophilus strain CBC-S77
            3CBC_contig_78, whole genome shotgun sequence.
ACCESSION   JABWOT010000126
VERSION     JABWOT010000126
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 00:25:14
            Original ID  :: JABWOT010000126.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14231
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14231
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3538:4231](-)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(3539..4231)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..14231
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14231
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             complement(2..229)
                     /locus_tag="ctg126_1"
                     /transl_table=11
                     /translation="LYVFDERIAVDVNHVDTIVVGKDLFDGTPFERSVHCGNPFCKRRI
                     LTSEEHEDKYLPGCPPDCRVHPRNRYVSEND"
     CDS             complement(248..916)
                     /locus_tag="ctg126_2"
                     /transl_table=11
                     /translation="MAKPIRVLLYYKYVPIENAEQFAADHLAFCKSIGLKGRILVADEG
                     INGTVSGDYETTQKYMDYVHSLPGMEDLWFKIDEEEEQAFKKMFVRYKKEIVHLGLEDN
                     NFDSDINPLETTGAYLSPKEFKDALLDEDTVVLDTRNDYEYDLGHFRGAIRPDIRNFRE
                     LPQWVRDHKEEFMDKRVVVYCTGGVRCEKFSGWLVREGYKDVGQLHGGIVTYGKEPEVQ
                     "
     CDS             complement(1105..1827)
                     /locus_tag="ctg126_3"
                     /transl_table=11
                     /translation="MTQFFYLLRWNYLRQKNLFILFTLAQVLLSVSLLFGYPLVIGKMD
                     TTTAYYLASGSVLMGVISIGCTISSPVIANAKSEGHVDYIRALPIPRILISLADLCIWL
                     IAILPGVFFTFLLGCLRFSVQLNLSILSVFVMLLICLTMISLGFSIAYIFSQNIVTLMS
                     QLILMIGLMFSPIMYPAGRLPDWLDQLYFLLPFVPSANLLRASFYRHGTVSLVDIGVLI
                     FWIFLTQLLILGTLQKEL"
     CDS             complement(1829..2740)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 171; E-value:
                     5.6e-52)"
                     /gene_kind="transport"
                     /locus_tag="ctg126_4"
                     /transl_table=11
                     /translation="MTFETLTIENLTKSFDKQHFANNHIFLELEAAKITALIGHNGAGK
                     STLLKQMIGFIKPDQGDVHYGDISFIHNRKQARTMMSYMSQQYAPLEKLTVEQNLEMIG
                     RMRGLSTSELQKEIEHLLADLEIVEYRDKKGKNLSGGLKRLTSFAMALIGSADIMLLDE
                     PTNDVDPVRREKQWRLLQKLAYKGHTIIIVTHNLLEVEKYADNFALFNHGKLLKSGPVH
                     QMSYKNHYQISFNFVSKEFLSLFEHFTMVNGCVCQMEIEESELTRILIQVKEGIEKGLI
                     SNLSVKMKTLSISDIYKEELVN"
     CDS             complement(2737..3411)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiF"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg126_5"
                     /sec_met_domain="ThiF (E-value: 9.7e-36, bitscore: 113.1,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VDFDIIEKSNLGRQFLYKEEDVGALKTQIAHQEVSKMNSDIEVET
                     HNLRITCVNDLLPLLDNVDIVICVIDEPQYDIQRIVNKAVVTKNIPCVFGASQVSRGRV
                     YSVVPHQTGCFDCLNIHYTKIDSLFLEQFRGIRTVTKKIPTIAYGPAMFQLTSAIVDEA
                     VRLITKYAEPMSLNRQYEINYENGASFTHKPWGHYPDECPTCGNGKEENWEIFSQYGEI
                     KL"
     CDS             complement(3539..4231)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Pantocin_Microcin_RRE"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg126_6"
                     /sec_met_domain="Pantocin_Microcin_RRE (E-value: 5.6e-14,
                     bitscore: 41.9, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLPSILSRKIFDRITTIRRGEIIESPRLSFFLKNSEEKMKFHCPR
                     IKEIYPIYKLHDNLFRVGSQIGITTEISDEDDKMWSLVNILDGRTINDVVDIMLTKYPD
                     LTEQDIIGAIELLDKEGVIEEGATINCIKERYHSNIYYFSRYLNXXXXXXXXXXXXXXX
                     XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
                     XXXXXLFK"
     CDS             4454..5164
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 58.2; E-value: 1.5e-17)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg126_7"
                     /transl_table=11
                     /translation="MLKVAICDDSDRDASQLEHYLLSYDKFPLETKLYTNPQKLLNQRT
                     PDIHCVFLDINMPGINGIDVAQKIRKFNPFIPIIFVTSYRDYMEQVFEVQTFDYIVKPI
                     EPQKLMKVLDRILRFLDMGQALFTFSFGKHNYSVPSSDIVFFEKDKRSVFIYTKTGTYK
                     SLLKTKEILEKLPNYFIQIHASYILNPKYIKDFDSKTVTILLNGTEEHLLPISRKFQFS
                     FKEKYYSYLSERHF"
     CDS             5164..6459
                     /locus_tag="ctg126_8"
                     /transl_table=11
                     /translation="MLVGLRIISILYDLFLASMLFYRPLSKINMKKKPLVALFFILIFH
                     GELVFLFSESRIFLVSNLLLNILEYYLIGLNFDYPIRQSSFWILLQTSLSLLAGAVLNQ
                     GIQLILPLGELSKNLEAISLYLGISFFLSTGITLILRKLLLSHQRLRIATSKGNWLYQF
                     IVPLLSIFFAFTISAIQGGVFGADYLSIISLSSLIVLTLSSLYFNLYLARQQQQYYQNQ
                     LEKEQLQFQVQEIQQSQEEYQRLQSLRHDLKNKHLTLLSLLEKNPEEAKDYLYSLTDSI
                     VGEQTFYSKNQTINFLLNQKLHHLKDEIEMEIDCFVPQELSIQPDILAVILGNCLDNSI
                     TACLRLPNKERNLSLNIRYFQQNLFINIRNNFDEKEKSTRKSRQKDGWGLRNIDALVQE
                     YQGNIKHFIKDGQYQIEILLPIKIGTIPTKEF"
     CDS             complement(6625..7326)
                     /locus_tag="ctg126_9"
                     /transl_table=11
                     /translation="MKKILVKNQVEGGKVAFELLKESLAAGAQTFGLATGSSPIALYQE
                     MVESDVDFSEFYSINLDEYVGLSPEHDQSYHAFMKAQLFDTKPFKESFLPDGMAEDLEK
                     AAKDYDDVLAHHIIDLQILGIGSNGHIGFNEPGTPFDSQTHVVDLTDSTIEANSRFFAS
                     RGQVPTKAISMGIASIMAAKKIILFAYGDKKADAIFKMLKGPVTEEVPASVLQNHPDVT
                     LILDQAAAAKL"
     CDS             7476..8519
                     /locus_tag="ctg126_10"
                     /transl_table=11
                     /translation="MNTNDFDFELPEELIAQTPLEQRDASKLLVIDPVTREMTDTHFDH
                     IIDQLNPGDALVMNNTRVLPARLYGEKTDTHGHVEFLLLKNTQGDQWEVLAKPAKRLKV
                     GAKVSFGDGRLTATVTEELDHGGRIVEFSYNGIFLEVLESLGEMPLPPYIHEKLEDRDR
                     YQTVYAKENGSAAAPTAGLHFTPELLQKIEAKGVKLVYLTLHVGLGTFRPVSVDNVDEH
                     EMHSEFYTLSQEAADTLNSVKAAGGRIVAVGTTSIRTLETIGNKYDGQLQADSGWTNIF
                     IKPGYQFTVVDAFSTNFHLPKSTLVMLVSAFAGREFVLEAYKHAIQERYRFFSFGDAMF
                     VTRPSEK"
     CDS             complement(8617..10404)
                     /gene_functions="resistance (resist) ABC_efflux (Score:
                     285.7; E-value: 4.4e-87)"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 328.6; E-value:
                     1.3e-99)"
                     /gene_kind="transport"
                     /locus_tag="ctg126_11"
                     /transl_table=11
                     /translation="MKDNKKKTTHSSSFGRLWSYLQVYRFPLYLAIFLKIISVIMSVIE
                     PVVIGLAITELTKNTLDIIKGVAGAHINVSYVGLVLVFYLLRGLIYELASYYSNYFMTN
                     AVQATVQDMRNEMIEKINRTSVSYFDKQQFGDLLGRFTSDVETVSNALQQSFLQVVNAI
                     FTLALVIGTVLYLNLQLGAVVVITIPISYFGARFIMSKSQPYFKQQADALGTLNGFVQE
                     NLTGFNVIKLFGREGRSLDDFKEITEDLQKVGFKANFISGLMMPFLNGLSDLTYLIIAV
                     LGGLQVLAGRLTIGNMQAFVQYVWQINQPIQNLTQLAGQLQSAKSSLDRIFQLMDEPDE
                     ANDATEVLEGDLTGQVIFNHVDFQYVADKPLIRDFNLEVNPGEMVAIVGPTGAGKSTII
                     NLLMRFYDVTAGSISVDGHDIRNLSRKDYRKQFGMVLQDAWLFEGTIKENLRFGNLEAT
                     DEEIVEAAKAANVDHFIRTLPGGYNMEINQESSNISLGQKQLLTIARALLADPKILILD
                     EATSSVDTRLELLIQKAMKTLMQGRTSFVIAHRLSTIQEADKILVLKDGQIIEQGNHES
                     LLADKGFYYDLYNSQFAEK"
     CDS             complement(10417..12153)
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 347.7; E-value:
                     2e-105)"
                     /gene_kind="transport"
                     /locus_tag="ctg126_12"
                     /transl_table=11
                     /translation="MSYIWSYLRRYPKWLAMNFTAAILFVIANLGMPTVLARMIDEGIN
                     RGDADKLYTYAWVMFGVVLTGIVGRVLLAYAVGKLTTTMVQVMRNDIYAKLQEYSHHEY
                     EQIGVSSLVTRITSDAFVLMQFADQVLKVGIITPLMMVSSVFLILTTSPSLAWIVAISL
                     PLLAVVVWYVAVKTRPLSEKQQATLDKINQYARENLTGLRVIRAFAREDFQEKKFASEN
                     AVYADNSSKLFKLTGLTEPLFVQIIIAMIVAIVWFALNPLGSGTLAIGDLVAFIEYSFH
                     ALLSFLFLANLFTMYPRTAVSSERLQEIMDMPISINPNEDGVTETDTKGYLEFDNVTFA
                     YPGETESPVLHNISFKAKAGETIAFIGSTGSGKSSLVQLIPRFYDVTLGRILVDGVDVR
                     DYNLKALRRKIGFIPQKALLFTGTIGENIRYGKENASHEELNQATDVAQAKEFIESKEE
                     RYDSHLAEGGSNLSGGQKQRLSIARAVVKRPDLYIFDDSFSALDYKTDATLRRRLKEVT
                     QDATVLIVAQRVGTIMDADQIIVLDKGEIVGRGRHEELMESNEIYREIANSQLNQKSLT
                     ED"
ORIGIN
        1 aatcattttc agagacataa cggttgcggg gatgaacacg gcagtcgggt gggcaaccag
       61 ggaggtattt gtcttcatgt tcctctgaag taaggatgcg gcgtttgcag aatgggttac
      121 cacagtggac agagcgttcg aaaggtgtgc catcgaacaa gtccttaccg acaacgatag
      181 tatccacatg gttgacatca acggcaatac gctcgtcaaa gacatacaac taaccatccc
      241 aaagttctca ttgaacctct ggttcttttc cgtaagtcac gataccacca tgcaattggc
      301 caacatcttt atagccttca cggaccaacc aacctgagaa tttctcacag cggacaccac
      361 cagtacagta aacaaccacg cgcttatcca tgaactcttc tttatggtcg cggacccatt
      421 gtggcaattc acggaagttg cgaatgtcag gacgaatggc tccacggaag tgaccaaggt
      481 catattcata gtcgttacgt gtatcaagga caacagtatc ctcatccaaa agagcgtctt
      541 taaactcttt gggtgacaag taagcacctg tagtttcaag tggattgatg tcgctatcaa
      601 agttattatc ctctaagcca aggtgaacaa tctccttctt gtagcgaaca aacatcttct
      661 tgaaagcttg ttcttcttcc tcatcaatct tgaaccaaag gtcctccatc cctggaaggc
      721 tatgaacgta gtccatgtat ttttgagtgg tttcatagtc tccagaaacc gttccattaa
      781 tcccctcgtc agcgaccaag atacgacctt ttagaccgat tgacttacaa aaagccaagt
      841 ggtcagccgc aaattgctca gcgttttcga tgggaacgta tttataataa agcaatactc
      901 gaataggttt tgccattgta cttcctcttt ctttatgaaa tatctatatt tgttgtttga
      961 taataaaatc aacttaacta ttataccgct atcaaagagg actaggcaat tgatttgttt
     1021 ggaggagaat tgtcacaaaa gaaaaaggct gagtaccaga tgtctaaacc tgagtttcgt
     1081 aagattgttt tccataagat agtattacaa ctctttctgt agtgtcccta agataagcag
     1141 ttgtgtcaga aaaatccaga aaataagaac tcctatatct acaagcgaaa cagttccatg
     1201 tctataaaag ctagctctaa gaagattcgc agaagggaca aatggaagta gaaaataaag
     1261 ttgatctaac caatctggaa gacgacctgc cggatacatg attggtgaaa acataagacc
     1321 aatcattaaa ataagctgag acattagcgt gacaatattt tgggaaaata tataagcaat
     1381 tgaaaatcct agactaatca ttgttaggca aataagtaac atcacaaaaa cagacaaaat
     1441 tgacaaattt aattggacag aaaagcgaag acagcctaat aaaaaagtga agaatacacc
     1501 tggtaaaata gcaattaacc atatacatag gtcagctaaa gaaattagaa ttctaggaat
     1561 aggtaaagct cgaatatagt ccacatgacc ttctgacttg gcattggcta taacaggaga
     1621 tgaaatcgta cagccaatag aaataactcc cattaaaact gatccagagg caagatagta
     1681 agcagttgtt gtgtccatct taccaattac caacggatac ccaaaaagaa gtgaaacgga
     1741 caaaagcact tgagctagtg tgaatagaat gaatagattt ttttgtcgaa gatagttcca
     1801 acgaagtaag taaaaaaatt gagtcatatc agttaacaag ctcctcttta taaatatcgg
     1861 aaatagataa tgttttcatc ttaactgaaa ggtttgaaat aagccctttt tctatacctt
     1921 ccttaacttg aatgagtatt cgggttaatt cactttcttc aatttccatc tgacaaacac
     1981 aaccattgac catcgtaaaa tgttcgaata gacttaaaaa ttctttacta acaaaattga
     2041 aagaaatttg ataatgattt ttataagaca tttggtgtac tggaccagat tttaataatt
     2101 taccatggtt aaaaagagca aaattatccg catatttttc aacttctagt agattgtggg
     2161 taacaatgat aatagtgtgt cctttataag ccagtttttg taataatcgc cactgttttt
     2221 cacgacgtac aggatcaaca tcgttggttg gttcgtcaag aagcatgata tcagcagagc
     2281 caattaatgc catggcaaaa gatgtaagcc gttttaagcc tcctgaaaga ttcttccctt
     2341 ttttatcacg gtattctact atttccagat ctgctagaag gtgctcaatt tctttttgga
     2401 gttctgaggt acttaaccct ctcattcttc caatcatctc taaattttgc tcaacagtta
     2461 acttttcaag aggtgcatac tgttgtgaca tataactcat cattgttcga gcttgtttac
     2521 ggttatgtat aaaagaaata tctccgtagt gaacatctcc ctgatcaggc ttaataaaac
     2581 caatcatttg ctttaaaaga gttgatttac cagcaccatt atgtcctata agagctgtga
     2641 tttttgcagc ttctagctct aagaagatat ggttattagc aaaatgttgt ttatcaaatg
     2701 attttgttaa attttcaatg gtgagcgttt caaaagtcat aattttattt ctccgtattg
     2761 agaaaagatt tcccaatttt cctccttacc gttaccacat gtaggacact catcaggata
     2821 atgtccccaa ggtttgtgtg tgaacgacgc tccgttttca taattaatct cgtattggcg
     2881 attaagactc attggttctg catatttagt tattaatcga acagcctcat caacaatagc
     2941 agatgtcaat tgaaacatag ccggaccata agcaattgta ggaattttct tagtaacagt
     3001 acgaataccc cgaaattgtt ccaagaatag actatcaatt ttcgtgtaat gaatgtttaa
     3061 acaatcaaaa catcctgttt gatggggtac tacagaataa acacgtccgc gactaacttg
     3121 acttgcacca aaaacacacg gaatattttt tgtaactaca gctttattta caatacgctg
     3181 aatatcatat tgtggttcat caataacaca aataacaatg tcaacattgt ctaataatgg
     3241 caacaagtcg tttacacatg ttatacgtaa attatgagtt tcaacttcga tatcagaatt
     3301 catttttgac acttcttgat gggcaatctg tgttttaaga gcccctacgt cttcctcctt
     3361 atataaaaat tgcctaccta gattactttt ttcaatgata tcaaagtcca caatttttat
     3421 ttttttaggt cccagaccag atagcaaagt tagtatattg gaccctcctc cgccaagtcc
     3481 taataaaaga actgtcgttt cattaagtct cttttgaata tctatactat ctttaaaact
     3541 atttaaatag cgnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3601 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3661 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3721 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3781 nnnnnctatt taaatagcga ctaaaatagt agatatttga atgatatctt tccttaatac
     3841 aatttattgt agcaccttct tcaataaccc cctccttatc caatagttca atagcaccta
     3901 ttatatcttg ttccgtcaaa tctggatact tagttaacat aatatctaca acgtcattaa
     3961 tagtccttcc atctaaaata ttaactaaac tccacatttt atcgtcctca tcactgattt
     4021 cagtagttat accaatttgg gagcctaccc taaacaaatt atcgtgaagt ttataaatag
     4081 gatatatttc ttttattctt ggacaatgga atttcatttt ttcctcacta tttttcaaaa
     4141 agaaagaaag acggggtgat tctataattt cccctcgcct tattgtagta attctatcaa
     4201 aaattttccg tgatagaatc gaaggtaaca tttgcttata tgtttattta acatttttaa
     4261 gcaattaaat aataccccag ctaatttcgg tttgagctac ggccttacgt acttgaatgt
     4321 ttttcatttg gaattctcct tgcatcttta ataagaatat tgtatgctaa acttacattt
     4381 ttcttacaat tatgtcataa ttgaccattt taacgttata actaacatac agaaatgagt
     4441 gaggaggttt tcaatgttaa aagttgctat ttgtgatgac tctgatagag atgctagcca
     4501 attagaacat tatttacttt cttatgataa atttcctcta gaaacaaaac tttatacaaa
     4561 tccacaaaaa ctcttaaatc agcggacgcc agacatccac tgtgtctttt tggatatcaa
     4621 tatgccagga atcaatggaa ttgacgtagc acaaaagatt agaaaattta atcctttcat
     4681 tcctattatt tttgtgacaa gttatcgtga ttatatggaa caagtcttcg aagttcagac
     4741 ttttgactat atcgtaaaac cgatagaacc tcaaaagtta atgaaagtat tggatcgtat
     4801 tttgcgtttt ttggatatgg gccaagcact ttttaccttc tcatttggta aacacaatta
     4861 ttctgtccct tcgagcgata ttgtattttt tgagaaagat aaacgttcag tatttatata
     4921 cacaaagaca ggtacctaca agtctctact aaaaacaaaa gagattttgg aaaaactccc
     4981 taattatttt attcaaattc atgcttccta tattttaaac cccaaataca tcaaagactt
     5041 tgattcaaaa acagttacta ttttactaaa tgggactgaa gaacacctac tcccaattag
     5101 tagaaagttt cagttttctt ttaaagaaaa gtattacagc tatctaagtg aaaggcattt
     5161 ttaatgttag taggattacg aataatcagt atcttgtacg atttatttct agcaagtatg
     5221 ttattttata gaccattgtc taaaatcaat atgaaaaaga agcctttagt agcccttttt
     5281 ttcatattga tttttcatgg ggaactcgtg ttcctattct ctgaaagtcg tatttttttg
     5341 gtcagtaatc tccttctaaa cattttagaa tactatctaa tcggtctcaa ttttgattat
     5401 cctattcgcc agtcttcctt ttggattctt ttacaaacta gtctaagttt gttagcagga
     5461 gctgtcctaa accaaggaat ccaactaatt ttacctttag gggaactatc aaaaaattta
     5521 gaagctatta gtttgtatct cggaataagt ttcttcttat ctacaggaat aactcttatc
     5581 ttacgaaagc ttctcctatc ccatcaaagg cttcgtattg ctacttctaa gggaaactgg
     5641 ctttatcagt ttatcgtgcc tcttttatct attttctttg cttttacaat atctgccatt
     5701 caaggagggg tatttggagc agattacctg tcaatcattt ctctctcatc tctcattgta
     5761 ttaactctct cctctcttta ttttaatctg taccttgctc gtcaacagca gcaatattac
     5821 caaaaccaat tggaaaaaga acaattacag ttccaagttc aagaaataca acaatctcaa
     5881 gaagaatatc aacgtctcca aagccttcgg catgacttaa aaaataaaca tttaactctt
     5941 ttatcgcttt tagagaaaaa tcctgaagag gcaaaagatt atctttattc attaacagat
     6001 agtatagtag gtgaacaaac tttctactct aaaaatcaaa ctattaattt tttacttaat
     6061 caaaaactac atcatttaaa agatgagata gaaatggaaa ttgattgctt tgtaccacaa
     6121 gaattatcta ttcaaccaga tattttagct gttatattag gaaactgcct agacaatagt
     6181 attacagctt gtctcagact accaaataaa gaaagaaact tatcacttaa tatccgatac
     6241 tttcaacaaa atctttttat caatattaga aataattttg atgagaaaga aaaatctact
     6301 cgtaaatccc gtcaaaaaga tggctggggg ttgcgaaata ttgatgctct tgttcaagaa
     6361 tatcaaggta atatcaaaca ctttataaaa gatggacaat atcaaataga gattttatta
     6421 ccaataaaaa tagggactat tccgactaaa gaattttagg taattgatga aaaatgagta
     6481 ataattaggt aacgtaaata tttgaagtca aaatctatat tatgtttatt cattaataaa
     6541 caggtggagt agcactagct caacctgttt ttttctataa ctttctgatt acctaactcg
     6601 catctgctcg actcatgttt tctcctacaa tttcgcagca gctgcttgat ccaagataag
     6661 agtcacgtct ggatgatttt gtaagacact agctggcact tcctctgtca ccggcccctt
     6721 aagcatcttg aaaatggcat ctgccttctt gtcaccatag gcaaacaaga ttatcttctt
     6781 ggcagccata atagaagcaa ttcccattga aatagccttt gtagggactt ggcctcgact
     6841 ggcaaagaaa cggctattag cttcaatggt gctatccgtc aagtcgacca catgggtttg
     6901 actatcaaaa ggcgtacctg gctcattaaa accaatatgc ccattacttc cgattcctaa
     6961 gatttgcaga tcaatgatat ggtgtgccaa gacgtcatca taatccttag ccgccttctc
     7021 caaatcttca gccataccgt caggtaagaa gctctcctta aatggcttgg tatcaaagag
     7081 ttgagccttc ataaaggcat gatagctctg atcatgctct ggtgatagtc cgacgtattc
     7141 atccaaattg atgctataaa attccgaaaa atccacgtca ctctcaacca tctcttggta
     7201 aagggcgata ggggaactac ctgtcgccaa tccaaatgtt tgagcacccg ctgcaaggct
     7261 ctcttttaga agttcaaagg caactttgcc tccctcaact tgattcttaa ctaaaatctt
     7321 tttcattcta ttcacctcaa tattggtata taccattttc tttattatct cttttttaac
     7381 cttcctgtca agcgttttca cttgataagt ttaatgactg tcgccctata tcgtgctata
     7441 ataaaaaggc tgaaaatttt taaacgagga aacaaatgaa tacaaacgat tttgattttg
     7501 aactaccaga agaactaatt gcccaaaccc cattggagca acgtgacgcc tctaaactct
     7561 tagtcattga tcctgtaact agggaaatga ctgataccca cttcgaccac atcattgacc
     7621 agcttaaccc tggagatgcc ttagtcatga acaatacgcg cgtgcttcct gcccgcctct
     7681 atggtgaaaa aactgataca cacggccatg tagaatttct ccttttgaaa aatacccaag
     7741 gtgaccaatg ggaagttttg gccaaaccag ccaaacgcct taaagtaggt gctaaagtca
     7801 gttttggtga tggtcgcttg actgccactg tcactgaaga actggatcac ggcggacgta
     7861 tcgtagaatt tagctacaac ggtatcttcc ttgaggtttt ggaaagctta ggcgagatgc
     7921 cactgccacc ttatatccat gaaaaattgg aagaccgcga tcgttatcaa acggtctatg
     7981 ccaaggaaaa tggctctgcc gctgctccaa cagctggact ccatttcaca cctgagttac
     8041 ttcaaaaaat tgaagctaaa ggcgtaaaat tggtctacct caccctccac gttggactgg
     8101 gaaccttccg acctgtttct gttgataatg tcgacgagca tgaaatgcac tcagaatttt
     8161 acaccctcag ccaagaagcg gccgataccc tcaatagtgt caaagctgct ggaggtcgca
     8221 ttgttgcagt agggacaacc tcaatccgaa cactggaaac aatcggaaat aaatatgatg
     8281 gccaactcca agccgactcg ggctggacca atatctttat caaaccaggt tatcaattca
     8341 cagtcgtgga tgccttttca accaacttcc accttccaaa gtcaaccttg gtgatgttgg
     8401 tttcagcctt tgctggtcgt gaattcgtcc tagaagccta caaacacgcc atccaagaac
     8461 gctaccgctt cttcagtttc ggagatgcca tgttcgtaac acgaccttcg gaaaaataaa
     8521 tagtgatgtt gagacttctc ttacagggga agtctctctt actgcacatc acattcagaa
     8581 aaaatccacc agttatgaac tgatggatta ttttgtttat ttctctgcaa attgactatt
     8641 atacaaatcg taatagaaac ctttatctgc aaggagggat tcatggttcc cttgttcgat
     8701 gatttgtcca tctttaagga ccaaaatctt gtctgcttct tggattgttg ataaacggtg
     8761 agcgatgaca aaacttgttc gaccttgcat aagtgtcttc atggcttttt gaatcaagag
     8821 ttccagacgg gtatcaactg atgaggttgc ctcgtccaaa atcaagattt tagggtcagc
     8881 caaaagtgca cgggctatgg tcaaaagttg cttttgtccc agtgaaatgt tacttgattc
     8941 ctggtttatt tccatgttgt agccaccagg cagcgtacgg ataaagtgat ccacattggc
     9001 agccttcgct gcttcaacaa tttcttcatc agttgcctca agattaccaa aacgaagatt
     9061 ttccttgata gttccttcaa agagccaagc atcctgaagc accataccaa actgtttacg
     9121 ataatcttta cgcgacaagt tgcgtatatc atgaccatca accgagatag aacctgcagt
     9181 aacatcatag aaacgcatga gaagattgat aatagttgat tttccagcac cggtaggacc
     9241 gacaatagcc accatttcac caggattaac ctcaagatta aagtcacgaa tcaaaggttt
     9301 atcagctaca tactggaagt ccacatgatt aaagataact tgaccagtta aatctccttc
     9361 aagcacctca gtagcatcat tagcctcgtc tggttcatcc atcagttgga aaatacggtc
     9421 caaggaagat ttagcactct gcaattgtcc agccaactga gtcaagttct gaataggttg
     9481 attaatctgc caaacgtact gaacgaaagc ctgcatatta ccaatcgtca agcgaccagc
     9541 caagacttgc aaaccaccta ggacggcaat aattagatag gtcaagtcag ataaaccatt
     9601 aaggaaaggc atcatgaggc ctgaaatgaa attggcctta aaacctacct tttgaaggtc
     9661 ttccgtaatt tctttaaagt cgtctaatga tctaccctca cgcccaaaaa gtttaatcac
     9721 attgaaacca gtcagatttt cctgaacaaa accgttaaga gtacctaggg catcagcctg
     9781 ctgcttaaag taaggttgag acttactcat aatgaagcga gcaccaaagt aagaaatcgg
     9841 aatagtgata acaaccacag ctcccaactg aagattaagg taaagcactg tcccaataac
     9901 caaggctaga gtaaagatgg cgttgacaac ctgcaagaat gactgctgca aggcatttga
     9961 aactgtctcg acgtcactag taaagcgacc caaaaggtct ccaaattgtt gcttatcaaa
    10021 gtatgacact gaggtacgat tgattttctc aatcatctca tttcgcatat cctgaaccgt
    10081 tgcttgcacg gcattggtca taaaatagtt ggaatagtaa gaagccaact catagatgag
    10141 accacgcaag aggtaaaaga ccaaaactaa accaacgtag gacacgttga tatgagcacc
    10201 tgctaccccc ttaatgatgt ccagtgtatt tttagtcagt tccgtaatgg ctaaaccaat
    10261 gaccaccggc tcaataacac tcatgatgac actaataatt ttcaggaaaa tagctaagta
    10321 aagtgggaaa cgataaacct gcaagtatga ccaaaggcgg ccaaaacttg aggaatgagt
    10381 tgttttcttt ttattatcct tcattttgac ctccttctag tcttctgtaa gactcttttg
    10441 attcaattgt gaattagcaa tctcacggta aatctcatta ctttccatga gctcttcgtg
    10501 acggccacga ccaacaattt cacccttatc aagaacgata atctgatcag catccataat
    10561 ggttcccaca cgttgagcca cgatcaagac cgtcgcatcc tgagtcactt cttttagacg
    10621 acggcgcaag gtcgcatcag tcttgtagtc caaggcagag aaggaatcat caaagatata
    10681 gagatcagga cgtttaacca ccgcacgtgc aattgacaaa cgctgcttct gtcccccaga
    10741 aaggttgcta ccaccctcag ccaagtgaga atcatagcgt tcttccttgc tttcaataaa
    10801 ttccttagcc tgagccacgt ccgtagcttg attcaattct tcatgactag cattttcctt
    10861 accataacgg atattttcac cgatagttcc agtaaagagt agagcttttt gtggaataaa
    10921 gccaatctta cgacgaagag ccttaagatt gtagtcacgt acatccacac catccacaag
    10981 aatacgtcca agtgtgacat cataaaagcg tggaatcaac tgtacaagtg atgattttcc
    11041 tgagcccgta gacccaataa aggcaatagt ttcacctgcc ttagccttaa aagaaatatt
    11101 gtgtagaaca ggactctcag tttcaccagg ataggcaaag gtcacattat caaattccaa
    11161 atatccctta gtatcagtct ctgtcacccc atcttcattt gggttgatag aaataggcat
    11221 atccataatt tcctgcagac gttcactaga taccgctgta cgaggataca tagtaaagag
    11281 attagctaga aagaggaagg ataatagtgc atggaaactg tactcaatga aggcaaccaa
    11341 gtccccgatt gccagagttc cagaacctaa tggatttagg gcaaaccaaa caatagccac
    11401 aatcatagcg atgataattt gtacaaaaag tggctctgtt aaaccagtca atttaaagag
    11461 cttgcttgaa ttatccgcat agacagcatt ttcagaggca aacttcttct cttggaaatc
    11521 ttctctagcg aaagcacgga tgacacgaag tccagtcaga ttttcacgag catactggtt
    11581 aatcttgtcg agagttgcct gttgcttttc agaaagcgga cgcgttttta ccgccacata
    11641 ccagacaact acagctagta aaggcaagga gattgccaca atccaagcca aagatggact
    11701 tgtcgtcaaa atcaaaaaga cactggaaac catcatcaaa ggagtgataa tacccacctt
    11761 gaggacttga tctgcaaact gcatgagaac aaaagcatcc gacgtgatac gagtcaccaa
    11821 agaagatacc ccaatttgtt cgtactcatg gtgtgaatac tcctgaagtt tggcgtagat
    11881 atcattacgc atgacctgca ccatagtagt cgtcaactta ccaaccgcat aggccaaaag
    11941 cacacgacca acaataccag ttaagaccac accaaacatg acccaagcat aggtataaag
    12001 cttgtcagca tccccacggt taattccctc atcaatcatt ctagcaagaa ccgtcggcat
    12061 acccaggtta gcaataacaa ataaaatggc tgccgtaaaa ttcatcgcta gccacttagg
    12121 gtaacgcctg agataagacc aaatataaga cataaatttt ctcccccttt tcttcttcat
    12181 ttagctatac ttttaggttc acaagaatcg atactaactt ccgaaacctt aaaaagcaca
    12241 taaaaagggc gtgacaagca cgcaaattac ctacattcta acaaatgaaa atattaaaag
    12301 caatagaaaa aagcaggact tacaccctgg ttttctttat taagcgactt gagtcgtcac
    12361 cttattattt taagagtaac tgaagcagac tgattctaat tactgatatt gctgaattta
    12421 tttaatgaat ttacattttg acaatttttt ggaaggatac taaagaatat ttgattgtaa
    12481 aatattttga gtgatctttc cagaatcccg attatatcat tatgatacca aagactataa
    12541 gcattttaag tcactgattt atcagtgtga cctggtctat gtgaaacata taggggacac
    12601 atcttaggaa cattaagaag ataagatgaa tgactataac tcaagccttt tctaggaatc
    12661 cttggaacat ccacaatctt agcctgtcgt ttaatcatac ggcaaataat tgatttaaat
    12721 aagggattgc caaatcgagc taaaacataa tcatcttcgt cattttacac ttgaactcac
    12781 gccaattagt taatacttct aaagttacat cgtctaaatc aattttacgc gatccagcaa
    12841 ccatctttgc ttgctactta gaatactaat ttccatattc aactttttaa agtgtttcat
    12901 aggcgttgag aagcttttta taaggtttat agccatccca attacactca atatatgata
    12961 tttattataa taaattaaga attcaatttt cagtttagtt tcctgaagag attatatatt
    13021 tttgtatttt taccaagaat aaattagtat aattttattt caattaaatt acatatactt
    13081 cctttagttc aatgtgcaca tattcctttc atagataaag taaaaaaact gatgaatcat
    13141 tcgattcatc agttttaagg aagatatgtt cattgcaaac aaatcgtatc aattagaaag
    13201 attaatcttc tttcttctta cgagctacaa gaccaaatcc actcaatact ccgagaagtc
    13261 caagtgctgc taggctagca ttatcttctg tacctgtatt tggaagttca cgtttgccat
    13321 ccatatattg aggtgtagaa ggtgatgctg gttgagctgc agttgttgga gttccattat
    13381 tatctccatt atctgtaggt cttacaggtt gtggtactgg aacatagttg attacagtat
    13441 cttctgttgg gttttcaggt gttggtggaa catatccttt acttggatcg tttggatcta
    13501 ctggtttcag tgggtttcca tttgaatctt ttggagttgt tcctggcact tgaggaatca
    13561 ctgttgttgg tgttcctggt tttgttggat ctgttggatc gtttggatat tgaggtttat
    13621 caagttttgg ttcctcgaat ccttctggta cttttggtac ccatgaacca agtttagtgt
    13681 agacaacttc gatattttca tctttagagt ctaccgttaa tcctgttgta gctgctactt
    13741 ctttttgttt agcatctttc aggatgtagc cttgaactac tggtgattca actttatcga
    13801 atgttgtatc tccatcttta gctgtccagt tgccgtaagt gatttcacct gttacagaat
    13861 taatcttacc ttcacgagtg aatgtaactt tatctgttac tttctgagct acttcctcac
    13921 ctttttcgtt aacggatgtg attgtacggt tcacgtggcg agttgtatca atctgtttaa
    13981 tgagatcttc tgtccatttt ggtccatcag ggttgttagg atcgattgga tcacctggtt
    14041 ttggtttatt tggatcattt ggattttctg gatctactgg tttgattggt tcaacgtgtg
    14101 gtttaaccgt tactacaaag ctttgatcta ctttcgtatc tttatcgaag ttcttatctg
    14161 tagctgttgt gaatccatca gttacgaggt cataccctag agctttaagt tcagcaagct
    14221 tagctactgt t
//
