LOCUS       c00191_JACBJR0..       14244 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JACBJR010000071.1 Ligilactobacillus salivarius strain FFIG58
            Lactobacillus_salivarius_FFIG58_contig_71_1, whole genome shotgun
            sequence.
ACCESSION   JACBJR010000071
VERSION     JACBJR010000071
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2022-06-21 18:39:45
            Original ID  :: JACBJR010000071.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14244
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14244
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4183:9420]"
                     /cutoff="10000"
                     /detection_rule="(Proline_reductase and (Pro_racemase or
                     GRDB) and not ACP_syn_III_C)"
                     /neighbourhood="10000"
                     /product="proline2aminovalerate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      4184..9420
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Proline_reductase and (Pro_racemase or
                     GRDB) and not ACP_syn_III_C)"
                     /neighbourhood="10000"
                     /product="proline2aminovalerate"
                     /protocluster_number="1"
     cand_cluster    1..14244
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Proline_reductase and (Pro_racemase or
                     GRDB) and not ACP_syn_III_C)"
                     /kind="single"
                     /product="proline2aminovalerate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14244
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="proline2aminovalerate"
                     /region_number="1"
                     /rules="(Proline_reductase and (Pro_racemase or GRDB) and
                     not ACP_syn_III_C)"
                     /tool="gutsmash"
     CDS             complement(18..1085)
                     /locus_tag="ctg191_1"
                     /transl_table=11
                     /translation="MQHQLDSKTHHSRQILLSLLFIVVLVLGLLYAKWVPYFQKSFVAA
                     STHNIGNAIVGNGHLGKALPWFSLSLGWNFTKAYFLAIYKAFIVALLVGSLVQVLLPVR
                     TIRKYMGGDKFSNSFWAMLMGVPTMMCTCCTAPVAVGLKRSKASTRSVVSFFLANPLLN
                     PATLIFMGFVLGWNYTIFRLIMGIIVVLLVSWFISKVAKEKMVNVPDNKMFDPIEYDDK
                     SLFTRWLEALGKLMLESIPAYVVIVFILGCFQGLIFPAVANLSNNPILGVIGLAILGTL
                     FVIPTAGEIPIIQTLLALGLAPAFVGTLIIALPALSIVSLSLIKPAFSWKSVSYMFGAV
                     VVMSIISGILGAIIL"
     CDS             complement(1229..2272)
                     /locus_tag="ctg191_2"
                     /transl_table=11
                     /translation="MLTSFGILFGFLFGFFLKRSHYCIAGGLRDITLEKNISGLISVLL
                     IIFIQAGIFFSLIKLGIMPAADYPNYSLIAMIIGGFVFGIGTVASSGCISTALVKVGDG
                     RITGLITMLSFIITVSSVNNGLLSNITAPLQNMTVHQDTMAQTLQPFAIYIILAILVIT
                     FIAMSSTLKKNKPSFNVPYNYTGLRNIIFERRLDTLWAAVIIGIVAGFAFLSNYLAHDY
                     GGFSITGPLSSWLTFLTSNGMSISWGMYFTVGIVLGSFVCSLGNGEFKLQGSDGKTLFK
                     AFIGGILMGFGAGLAKGCLVSNGLVYTAMFSIQGWIALVSIFFGITCSSLLMFQIIPSH
                     HLSYANR"
     CDS             2426..2644
                     /locus_tag="ctg191_3"
                     /transl_table=11
                     /translation="MNYSLDTSGKDCPIPLMELKREIKGKSKGDVIDLTFTCPEAVNNI
                     PEYCEKNNYNIKEFTKNNNSWNIKVEI"
     CDS             2659..3732
                     /locus_tag="ctg191_4"
                     /transl_table=11
                     /translation="MKKSLIVLGLAASLFMGAYSSVSADCKTGNSSTTVAKPAAEKDKL
                     VKDSQEVTDNTYFVNAKWVKDQIKNNPKTVVLSVAYGKVPGFSKGHVPTAMQFSTNNIE
                     SEKNHWNILSPEACRKAFTKYGVTKDTNLIVYSPDVMAASRVAFVAYWLGVKDVKIMDG
                     GLQAWKNAGYSLEKKSTEPKKVDSFGTDKVAHPEVLISTPNDLLKDEKANKDMVLVSTR
                     SKKEYMGNISGYNYIKNTGEVKGAVYGKISKTSGDVAYLTNDDKTMKNPAEELKYWKDH
                     GITPDKEVVFYCGTGWRATAAFFLAKEEGYNNVKIYDGGWYDWDKSHQKDPKKYPVQKG
                     TPGTSSYKVYAGNEASR"
     CDS             complement(3845..3967)
                     /locus_tag="ctg191_5"
                     /transl_table=11
                     /translation="MGSGVPSGLQNQYEELRASWVGSIPTLSRHIDNEKVISQL"
     CDS             4184..6088
                     /gene_functions="biosynthetic (rule-based-clusters)
                     proline2aminovalerate: Proline_reductase"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg191_6"
                     /sec_met_domain="Proline_reductase (E-value: 4.2e-194,
                     bitscore: 634.4, seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSISVEQAKEHAKDPAVLCCRREAGKVLEAADFEDPTLFDDYVSS
                     GLLEIPEDTLTIEQALGATLNTTTDALNPLVPGIVDNIQGNEEASESDKDENVEEETPV
                     VAEANNEVVNSTSSNGTFHLRIAKGEGIDLEIPLDVLKKNTANSVVDVPKAETSADVTN
                     KDVAEDEESAEDAKVVRTLTKKYFKVDEVKFGDTTKFDGTTLYLRNPKELCKEAVDTEE
                     IVKDMEIEIITPDDYSNYSNTIMDVQPIATKEGDSDLGVGVTKVVDGAVVVLTGTDENG
                     VQVGEFGSSEGPLNENIMWNRPGAVDKGEIMIKIDVVIEAGTNRERKGPLGAHLAADYI
                     TQEIREALKDVDDSSAVKTEEFVQKRHPKQKRVLIVKEIMGQGAMHDNLIMPVEPVGTL
                     GAKPNVDLGNLPVVLAPTELLDGGVHALTCIGPASKETSRHYFREPLVEEAMADEDIDL
                     VGIALVGSPQENVQKFYVSKRLGMMVEAMNLDGAIVTTEGFGNNHIDFASHIEQIGERG
                     VDVVGMTYAAVQGQLVVGNKYMDAMVDNNKSRQGIENEILENNTLSREDAIRALAMLET
                     KMAGGSIKKPERQWNPNVKQNNIEIIEKETGKKIDLVENEQSLPMSKKRREIYEKDAQ"
     CDS             6090..6407
                     /locus_tag="ctg191_7"
                     /transl_table=11
                     /translation="MEEQSTGFDKLKYASTERVWEGIIIELTDASVIIDLKGRLGRLEI
                     PNRMIISDYELKVGEEVAFLMSYPEVLDSEPNQKYLGALNAYHKKMKEIKEKQRRDKNE
                     S"
     CDS             6397..6849
                     /gene_functions="biosynthetic (rule-based-clusters)
                     proline2aminovalerate: GRDB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg191_8"
                     /sec_met_domain="GRDB (E-value: 3e-22, bitscore: 69.4,
                     seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLKKYDGLQSEIFVPITPTPVWAPVKKKLKDMTVAIVTAAGVHL
                     KSDKPFNLAGDTSYRVVPSTATDDELMVSHGGYDNTDVNRDINCMFPIDRLRELAEKGF
                     IKDIAPNMYTCMGGGGDVKVFTEETGPEIAQKLLDEHVDAVVMTAG"
     CDS             6877..7122
                     /locus_tag="ctg191_9"
                     /transl_table=11
                     /translation="VQRAIESVGIPTIIIAALPPVVRQQGSPRAVAPRVPMGANAGEPH
                     NVEMQTGILKDTLEQLEKLDSPGKIVPLPYEYIANI"
     CDS             7142..7882
                     /gene_functions="biosynthetic (rule-based-clusters)
                     proline2aminovalerate: Proline_reductase"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg191_10"
                     /sec_met_domain="Proline_reductase (E-value: 1.4e-49,
                     bitscore: 159.1, seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDDILKIREFHVKDVVFGDGYSFKDSVLTIPQSVNFDLPKEILS
                     INIRIIKKDNRHLKVNSIMDIIPISTKVSGKIGTGVSHTLTGVEVMLTGASASGIQIHD
                     FGSSDGYLDEKMVFGRNGTPDENDIIIGLDVITAEDYSLDRAVITKIFELVDDFIQPIR
                     KILKVTNGRYADYVGEYRNNISNGKPKVVVIKQVSGQGAMYDNILFPNEPCGIKGGVSI
                     IDMNNFPTIVTPNEYRDGIIHALV"
     CDS             7903..8376
                     /gene_functions="biosynthetic (rule-based-clusters)
                     proline2aminovalerate: Proline_reductase"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg191_11"
                     /sec_met_domain="Proline_reductase (E-value: 2.4e-25,
                     bitscore: 79.5, seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGVGPSTKETTLHHYHDPLVKVFGDDPDIDFQGVVIVGTPQDNKL
                     KEEVGYRVAKFLKAMRTNGAVISADGWGNSDVDFMNTIESIGDEGISIIGLKFIGTQAT
                     FVVSNEYTPYVLDINKSEKGIETTVVGENNLDERDAHKALGYLKLKMRSDGNS"
     CDS             8401..9420
                     /gene_functions="biosynthetic (rule-based-clusters)
                     proline2aminovalerate: Pro_racemase"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg191_12"
                     /sec_met_domain="Pro_racemase (E-value: 9.1e-128, bitscore:
                     415.9, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLSQMLNVIDSHTAGEPARIVVGGIPVLKGKTVAEKKQYLIDHK
                     DNLRKSIMLEPRGHNAMFGAFLIPATSDEADFGIIFMDTGGYLNMCGHNTIAAVTAIVE
                     TGMVDIDEDTREKDVTLETPAGLVHATAHLDSPYHVKNVSFRNVPAFLYKKDVIVDVPD
                     VGKVKMDISFGGSFFAILDIEQLNETIDSSNAEKLDSIGMKILKAVNEQVKVQHPTLDY
                     INTVDLVEMYSKHPQSEDATMQNVVVFGDGQVDRSPCGTGTSAKLATLFAKGEIGINEK
                     FVYESILNTEFTGRVIEKVSIGGVDAITPEITGSAYITGFNTLLFDPSDPLSNGFELK"
     CDS             9433..10311
                     /locus_tag="ctg191_13"
                     /transl_table=11
                     /translation="MNLVLIIQIILGICLVYFTIIWLKDLIKNKNKLNDGNLLLSGVIG
                     FVTNFFDTLGIGSYAPTTMLLKLTKYVKNDKLLPGTLTIACSIPVLTEAFLYINTVKVE
                     AATLLSLIIAAAVGSFLGSKFISRIDEKKIQVMMGFALIITAILMCLSNTGVLASLGNG
                     NVAVGLTGWKLFIGILGNFILGALMTAGIGLYAPCMAMVYLLGLSPLVAFPIMMASCAV
                     LMPVASREFIKDGNYNRNATIGITIGGILGVFVAVTLVKSMSLTLLTWLVIIVLIYTAI
                     TMLMQGFKKEA"
     CDS             10407..12005
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AA_permease_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg191_14"
                     /sec_met_domain="AA_permease_2 (E-value: 8.6e-50, bitscore:
                     159.8, seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNKKKISLFSGVMLALSSLIGSGWLFGSEQAAKVAGPAAIISWI
                     IGAIIMMVIAFNYVELGTMFPESGGMSRFAQYSHGSFLGFIAAWGNWVSLITLIPIESV
                     AAVQYMSSWPWSWANWTAKFFHGSSITTQGLLMVYLFMIVFTLINFWSVRILTRFTSLI
                     SFFKLIVPTLTIIVLLVEGCHPGNFGHSVSTFMPYGTSSIFEATTVSGIILSYDAFQTV
                     INMGGEMEKPEKNILRGIVISLTITALIYIMLQVTFISSVDPRLIASVGWKGISFTSPF
                     ADIAILLNLNWLSILLYTDAFVSPFGTGVAFVATSARTLSAMTKNGTVPPVLGKLNKKY
                     GIPRYAMAADLGLAMILVFFFRDWSKLATVVSISTFIAYLTGPVSAVALRKLRPNFKRP
                     FKSNWLYILAPVSFVLTSMVIYWAMWPTTVEVIFVVLLGLPLYFYYESKNMRTTWKEQL
                     HGGLWMVVYLIFISLMSYFGSKGYGGNNTIKYPMDFVIVIIGSLIIYAWAVASRIDNPD
                     LDDAEKLNNTVKSEN"
     CDS             12098..12724
                     /locus_tag="ctg191_15"
                     /transl_table=11
                     /translation="MRKVDALGLECPIPVVKTKKALEEEDVVEVLVDNDTSVKNLEKMA
                     KQKEYGFKVDKEENHYKITISKNNDTKTTVEEKHKNEKIMKSTIEDITFESPKGYIVVI
                     NTDSVGHGDEKLGKILLKSFIYSLTGQDVLPEYILLYNGGVKLTVEDSDSFQDLKDLEE
                     AGVKIMSCGICLDYYDLKDKISVGEVTNMFRIVELMRTANRVVRP"
     CDS             12812..13090
                     /locus_tag="ctg191_16"
                     /transl_table=11
                     /translation="LKKQPFTMIVFNSTHAAIEASEILKNNKQVNRIVNTPGKIENGCG
                     LSIYVNDTDVDKITEPIQSFLDDKKVKAIYSGEKEGLSRSYTLIKEI"
     CDS             13090..14244
                     /locus_tag="ctg191_17"
                     /transl_table=11
                     /translation="MMGIILATAGHVDHGKTTLIKKLTGIDTDTTEEEKKRGLTINLGF
                     AHLKLPNKSTIGIVDVPGHEKFLKNMLSGLSGIDAALLVVDPNEGVMPQTIEHARILLL
                     LGVTKFIVVITKVDTVDKDMVELVHEDIKESFSGTPIEKAEFFDVDAVSGTGVTDLIYG
                     IQKLCSSIDNTDISGYPRLNIDRSFSLKGIGTVVTGTLQDGNLSLDDKLVLYPQEKEVN
                     IKNIRVYEGNTTSAQYSTRTALNITLPSETFHRGDALATPNTIEVVDRINVVCDILSIP
                     DLDLKLNDRVRVYMGSKEVYGRIYPLGKNEIIPGETNFLQIRLEDNIAVRYQDKFILRS
                     YSPIKVIGGGRVLEMNPTNKRRFDSDTLKRLEIRLENKCTDVILE"
ORIGIN
        1 tatataatag gaagagatta taaaataatt gcacctaaaa taccagatat aatactcatt
       61 actactaccg caccgaacat gtaactaacg ctcttccatg aaaatgctgg tttaatgagt
      121 gataatgata caatactcaa agcgggtagg gcaatgatta aagtacctac aaaagctgga
      181 gcaaggccaa gagctagtaa agtttggata attggaattt caccagcagt tggaataaca
      241 aataaagtac ctaaaatagc taaaccaata actcctagaa taggattatt acttaaattt
      301 gcaacagcag ggaaaatcaa tccttggaaa catcccaaaa taaatactat aacaacgtaa
      361 gcagggatac tttcaagcat taatttaccg agagcttcga gccagcgtgt gaatagtgat
      421 ttatcatcat attctattgg atcaaacatt ttattgtcag gaacattaac cattttttct
      481 ttagcaactt tgctaatgaa ccaagaaacc aatagaacaa caataatacc cataattaaa
      541 cggaaaatag tataattcca tcctaagaca aatcccataa atattaaagt agcgggattt
      601 aacaatggat tagctaaaaa gaatgaaaca acactcctag tagaggcctt tgaacgcttt
      661 aaaccgacag caacgggagc tgtacaacat gtacacatca ttgtaggaac acccattagc
      721 atagcccaaa aagagttact aaatttatct ccacccatgt attttctaat agtgcgaact
      781 ggtagtaaaa cttgaacgag agaaccaact aataaagcaa caataaatgc tttgtaaata
      841 gctaaaaaat aagctttagt aaagttccag cccagtgaga gtgaaaacca aggtaacgct
      901 ttccccagat ggccgttacc gacaatcgca ttacctatgt tatgtgtgct tgctgcaaca
      961 aatgattttt gaaaatatgg aacccatttt gcataaagca agccaagaac taaaactaca
     1021 ataaagagta aactgagtaa aatttgtcta ctatggtgag tcttagaatc taattgatgt
     1081 tgcataaaaa actccttctt tctacttaca aattgtaaat taattatttc aaaataatta
     1141 tatcacaata attttaaaat tgttcaataa ataacaaaca aatcaaaaaa tttattttat
     1201 taaattctta aaattaaatt taaaatatct atctattagc ataacttaaa tgatgagaag
     1261 gtataatttg aaacattaga agtgatgaac aagttatacc aaagaaaata gaaacaagcg
     1321 ctatccatcc ttgaatagag aacatagcag tgtataccaa tccatttgat actagacagc
     1381 ctttagctaa gccagcacca aatcccatta aaataccacc aataaatgct ttaaataaag
     1441 tttttccatc gctaccttgt aatttaaatt caccatttcc taatgaacaa acaaaagatc
     1501 ctaatacaat tccaacggta aagtacattc cccaagaaat tgacattcca tttgaagtta
     1561 aaaaagttag ccacgaagaa agaggaccag taattgaaaa gccaccataa tcatgtgcta
     1621 aatagtttga tagaaaagca aatcctgcaa cgataccaat aataactgct gcccagagag
     1681 tatctagtct tctttcaaaa atgatattac gtaatccagt gtaattgtaa ggaacattaa
     1741 aagaaggttt attctttttt aatgtagaag acatagctat aaatgtaata actagaattg
     1801 caaggataat gtatatcgca aaaggttgta aagtttgagc catagtatct tgatgaacag
     1861 tcatattttg taaaggtgca gttatattag agagtagacc attatttacg gaagatacag
     1921 taataataaa gctcaacatg gtaattaaac cagtgattct accatctccg actttgacaa
     1981 gagcagttga aatacagcca ctcgaagcaa cggtgcctat tccaaaaaca aatccaccta
     2041 ttatcatggc tattaaagaa taattaggat aatcagcagc aggcatgatt cctaatttta
     2101 ttaacgagaa aaaaattcct gcttggataa aaataatcag taaaacagaa ataagtcctg
     2161 agatattttt ttctaaagtt atatccctaa gaccacctgc aatacaataa tggcttcttt
     2221 ttagaaaaaa tccaaataga aaaccaaata aaattccaaa agaggttaac ataacatatc
     2281 ccaccttaaa gtaaaaacaa ttataaacat ttttcattat aaagataaaa aataaattat
     2341 caagattttt tggaaaacgt ttcacaaaaa aataaaaagg tgtataatcc taagtgaaaa
     2401 ttaacacaaa gaggtgtgag aaattatgaa ctatagtctt gatacaagtg ggaaagattg
     2461 cccaatacct ttaatggagc taaaaagaga aattaaaggt aaaagtaaag gagatgttat
     2521 agatttaact tttacttgtc cggaagccgt caataatatt ccggaatatt gtgaaaagaa
     2581 taattataac attaaagaat ttactaagaa caacaatagt tggaatatta aagttgaaat
     2641 ttaaaggaga aaaggtaaat gaaaaagtcg ttgatagttt taggtttggc tgcatcttta
     2701 tttatggggg catatagtag tgtaagtgcc gattgtaaaa ccggtaatag ttcaacaacg
     2761 gtggctaagc ctgctgcaga aaaggataag ttagtaaaag actctcaaga agttactgat
     2821 aatacatact ttgtaaatgc taagtgggta aaggatcaaa ttaaaaataa tcctaaaaca
     2881 gtagtgctct ctgttgctta tggaaaagtt ccaggcttct caaagggcca tgttcctact
     2941 gcaatgcaat tcagcacaaa taatattgaa agcgaaaaaa atcactggaa tattttaagt
     3001 cctgaagctt gtcgtaaagc ttttacaaaa tatggtgtta ctaaagatac taacttgata
     3061 gtttattcac cagacgtaat ggctgcatct agagttgctt ttgtagcata ttggttaggt
     3121 gtaaaagatg taaaaattat ggatgggggc ctacaagctt ggaaaaatgc aggttatagt
     3181 ctagaaaaga agtcaactga accaaagaaa gttgatagtt ttggtacaga taaagttgct
     3241 catccggaag ttttaatttc tacaccaaat gatttattga aggacgaaaa ggctaataag
     3301 gatatggtat tagtaagtac acgttctaag aaagaatata tgggaaatat tagtggatac
     3361 aactacatca agaatactgg agaagtaaag ggtgcagtat acggtaagat tagtaaaact
     3421 agtggtgatg tagcttatct aacaaatgat gataagacaa tgaaaaatcc agcagaagaa
     3481 ttgaagtatt ggaaagacca cggtattaca cctgataaag aagtggtatt ttattgtggt
     3541 acaggatgga gagcaactgc tgcattcttc ttagctaaag aagagggata caataatgtt
     3601 aagatctatg atggtggttg gtacgattgg gataagagtc atcaaaaaga tcctaagaag
     3661 tatcctgttc aaaaaggaac accaggtaca tcaagttata aagtatatgc tggaaatgaa
     3721 gcatctagat aattgataga ataaataaga aacaatttat cgattttgta tcattataat
     3781 cgataaattg tttttttatt tttatataga aaaagaaaaa ccggagttaa cttgtaactc
     3841 cggctcataa ttggcttata accttttcat tatctatatg gcgggaaagt gtaggaatcg
     3901 aacctaccca agaagctctt aactcctcat actggttttg aagaccagag ggaacaccag
     3961 aacccatcca ttcccattca gtataatagc ataatatgtg aattattgca aattataaca
     4021 tttaaaaatt acattgaaat attttttgat agtgatataa ttaacatgca atattgagaa
     4081 aacgtgtaca tttaccctat atgtggaata ttaatactta ctaaaataat atatatgtta
     4141 ctcaatattg taattaaact tatagaagtt aggaggaaat tctatgtcaa tttcagttga
     4201 acaagctaaa gaacatgcta aggatccagc agttctttgc tgtagaagag aggcaggaaa
     4261 agttctggaa gctgccgatt ttgaagaccc aactttattt gatgactatg ttagttcagg
     4321 acttttagaa atacctgaag atacgttaac tattgaacaa gcattgggtg caacattaaa
     4381 tactactaca gatgcattaa atcctttagt tcctggtatt gtagataata ttcagggaaa
     4441 tgaagaagca tctgaaagtg ataaagacga aaatgttgaa gaagaaacac cagttgtagc
     4501 agaagctaac aatgaagtag taaattcaac atcatcaaat ggtacattcc atttaagaat
     4561 cgctaaaggt gaaggtattg atttagaaat acctttggat gtattaaaaa aaaacacagc
     4621 taactcagtt gtagatgtcc ccaaggcgga aacaagtgct gatgtaacta ataaagatgt
     4681 tgcagaagat gaagaatcag cagaagatgc taaagttgtt cgtactctaa ctaaaaaata
     4741 cttcaaagta gatgaagtta aatttggaga cacaacaaag tttgatggaa caacacttta
     4801 cttacgtaat cctaaagaac tttgcaaaga agctgttgat actgaagaaa ttgttaagga
     4861 tatggaaatt gaaattatca cacctgatga ttattccaac tatagtaaca ctattatgga
     4921 cgttcaacca atcgctacaa aagaaggaga tagtgatttg ggcgtaggcg ttacaaaagt
     4981 tgtggatggt gctgtagtag tactcacagg tactgatgaa aatggtgtcc aagttggtga
     5041 atttggttct tcagaaggtc cattgaatga aaatattatg tggaatcgtc ctggtgcagt
     5101 tgataaaggc gaaatcatga ttaagattga tgttgttatc gaagctggaa ctaaccgtga
     5161 acgtaaagga cctttaggag cacatttagc agcagattac attacacaag aaattagaga
     5221 agcgctaaaa gatgttgatg atagttcagc agttaaaact gaagaatttg ttcaaaaacg
     5281 tcatcctaag caaaagagag tattaattgt aaaagaaatc atgggtcaag gtgcaatgca
     5341 cgataattta attatgcctg tggaaccagt tggtactctt ggtgcaaagc caaatgttga
     5401 cttaggtaac ttgccagttg tattagctcc aacggaatta ttagatggtg gtgtacatgc
     5461 tttaacatgt attggacctg cttctaagga aacatcaaga cattacttca gagaaccttt
     5521 ggtagaagaa gcaatggctg atgaagatat tgatttagtt ggtattgcat tagtcggttc
     5581 acctcaagag aatgttcaaa aattctacgt ttctaagaga ttaggtatga tggtagaagc
     5641 tatgaattta gatggtgcta ttgttacaac agaaggattt ggtaataacc atatcgactt
     5701 tgcttctcac atcgaacaaa ttggtgaaag aggagtagat gttgttggaa tgacatatgc
     5761 tgctgtccaa ggacaattag ttgttggtaa taagtatatg gatgcaatgg tagataacaa
     5821 caaatctcgt caaggtattg aaaacgaaat tcttgaaaac aatactctat cacgtgaaga
     5881 tgctatcaga gctttagcaa tgttggaaac aaagatggct ggtggatcaa ttaagaaacc
     5941 tgaacgtcaa tggaatccaa atgttaagca aaacaatatt gaaattattg aaaaagaaac
     6001 cggtaagaag attgacttag ttgagaatga acaatctcta ccaatgagta agaagcgtcg
     6061 tgaaatttac gaaaaggatg ctcaatagta tggaagaaca aagtacagga tttgacaaat
     6121 tgaaatatgc ctcaaccgag agagtatggg agggcataat aatagaattg acagatgcga
     6181 gtgtcataat tgatcttaaa ggacgtctag gtagactaga aattcctaat agaatgatta
     6241 ttagtgatta tgagttgaaa gtcggtgagg aagtagcatt cttaatgtca tatcccgaag
     6301 ttttggatag tgaacctaat caaaaatatt taggagcact aaatgcatac cataaaaaaa
     6361 tgaaagaaat aaaagaaaag caaaggagag ataaaaatga gtcttaagaa atatgatgga
     6421 ctacaatccg aaatatttgt acctattact cctacgccag tgtgggctcc agttaaaaag
     6481 aagctaaaag acatgactgt agcaattgta actgctgctg gtgtacattt gaaatcagat
     6541 aaaccattta atttagctgg tgatacttca tatagagtag taccttcaac tgcaactgat
     6601 gatgaattga tggtatcaca tggtggttat gataacactg atgttaacag agatattaac
     6661 tgtatgttcc caattgatag attaagagaa cttgcagaga aaggatttat taaggatatt
     6721 gcgccaaaca tgtatacatg tatgggtggt ggtggagacg ttaaagtctt tactgaagaa
     6781 actggtccag aaattgccca aaaattattg gatgaacatg tagatgctgt cgtaatgact
     6841 gctggttgag gtacctgtca tagaactgcc gtgatcgtgc agagagctat tgaatcagtt
     6901 ggtatcccaa caattattat tgcagcctta cctccagtag tacgtcaaca aggatctcct
     6961 agagctgttg ctcctcgagt tcctatgggg gctaacgccg gagaaccaca caacgtcgaa
     7021 atgcaaacag gtattttgaa agatacgtta gagcaattag aaaaattaga ttccccaggt
     7081 aagattgtgc cactaccata tgaatatata gcaaatatat agttatattg gaagtgttat
     7141 tatgtcagat gatattttaa aaatcagaga attccatgta aaagatgtag tttttggaga
     7201 tggatactct tttaaggata gtgttttaac tatacctcag agtgtaaatt ttgatttacc
     7261 taaagaaata ttgtcgataa atattaggat aataaaaaaa gataatcgtc atttaaaggt
     7321 taactctatt atggatatta tacctatatc tactaaagtt agtgggaaga tagggactgg
     7381 agtttcccat acattgacag gtgtagaggt tatgttgact ggtgcttcag caagtggtat
     7441 ccaaattcat gactttggat cttccgatgg atatttagat gaaaaaatgg tttttggaag
     7501 aaacggtacg cctgatgaga atgacattat cataggccta gatgttataa ctgctgaaga
     7561 ttatagtcta gatcgtgcag ttatcactaa aatttttgaa ttggttgatg attttataca
     7621 acctattcga aagattttga aagtaaccaa tggacgttat gctgattatg taggtgaata
     7681 taggaataat atttcaaatg gtaaacctaa agtagtagtt attaaacaag tttctgggca
     7741 aggtgctatg tatgacaata ttttatttcc taatgagcct tgtggtataa aaggtggagt
     7801 ttcgattatt gatatgaata actttccaac aatagtaact ccaaatgagt accgtgatgg
     7861 cataatacat gcattggttt aattagatgg aagtgatgtt ttatgggtgt tggtccttca
     7921 actaaggaaa ctacattaca tcattatcat gatccgttag taaaagtttt tggcgatgat
     7981 ccagatattg actttcaagg tgttgttata gtgggaacac ctcaagacaa caagttaaaa
     8041 gaggaagttg gatatagagt tgctaaattc ttaaaagcta tgagaactaa tggtgcagta
     8101 atttctgctg acggatgggg aaactctgat gtggatttta tgaatactat tgaatctata
     8161 ggtgatgaag gtatctcaat tattggatta aaatttattg gaactcaagc aacatttgtt
     8221 gtatcaaatg aatatacacc atatgtttta gatataaata aatctgaaaa gggtatagaa
     8281 acaacagttg ttggggaaaa taatttagat gaacgagatg cacataaagc cttaggatat
     8341 ttaaagctta aaatgcgttc agatggtaat tcctgatgaa ctacgaagaa ggtaaggttt
     8401 atgagattat cacaaatgtt gaatgtgatt gattcccata cagcaggaga accagcaaga
     8461 attgttgttg gtggaattcc tgttttaaaa gggaaaacag ttgctgaaaa gaaacaatat
     8521 ttgattgatc ataaagataa tttaagaaaa tctatcatgc ttgaacctag aggacacaat
     8581 gcaatgtttg gagcattttt gatcccagct acaagtgatg aagcagattt cggcattatc
     8641 tttatggata ctggtggata tttaaatatg tgcggccata atactattgc tgcagttaca
     8701 gctatagtag agactggaat ggttgacata gatgaagaca ccagggaaaa agatgtcaca
     8761 ttagaaacac cagccggttt ggtgcatgca acagcacatt tagattctcc atatcatgtg
     8821 aagaatgtat cgtttagaaa tgtacctgca tttctatata agaaagatgt aattgttgat
     8881 gttccagatg ttggtaaagt aaaaatggac atttcatttg gtggtagttt ctttgcaata
     8941 ttagatatag agcagttaaa tgaaactatt gatagtagta atgcagagaa acttgatagc
     9001 atcggaatga agatcctaaa ggctgttaat gaacaagtaa aagttcagca tcctacttta
     9061 gattatatca atacggttga tctggtagaa atgtacagca agcatcctca atctgaagat
     9121 gcaactatgc aaaatgtagt agtttttggt gatggtcaag ttgatcgttc tccttgtggt
     9181 acaggtacta gtgctaaatt agcaacttta tttgctaaag gagaaatagg cattaacgaa
     9241 aagtttgttt acgagagcat cttaaacact gaatttaccg gaagagttat agaaaaggta
     9301 agtattggtg gtgttgatgc aattacaccc gaaattacag gttcagcata tatcacaggc
     9361 ttcaatacac tattattcga tcctagtgat ccgttaagta atggtttcga attgaagtaa
     9421 ggatgtgatt aaatgaatct ggtattaata attcaaataa ttttaggaat atgtttagta
     9481 tattttacaa ttatttggtt gaaagattta attaaaaata aaaataagtt aaatgatggc
     9541 aatttacttt tatctggtgt gataggtttt gttactaact tttttgacac attagggatt
     9601 ggtagctatg caccaactac aatgctacta aaactaacta agtatgtgaa gaatgacaag
     9661 ttattgccag gtactttgac aattgcttgt tcaattcctg tcttaacaga agcttttctt
     9721 tatatcaata ctgtaaaagt agaagcagca actttgctat cattaattat tgctgcagca
     9781 gtgggctcgt ttttaggatc taagtttatt tctcgtatag atgaaaagaa aatacaagta
     9841 atgatgggct ttgcgttgat tataaccgca attttaatgt gtttatctaa taccggtgtt
     9901 ttagcaagct taggtaatgg aaatgttgca gttggtttaa caggatggaa actatttatt
     9961 ggtatattag gtaactttat attaggtgct ttgatgacag ccggtatcgg cttatatgca
    10021 ccttgtatgg caatggttta cttactaggt ttgtcgccat tagtagcctt tccgataatg
    10081 atggcatcct gcgcagtttt aatgccagtt gcaagtagag agttcataaa ggatggtaat
    10141 tacaatagaa atgctactat tggaattact atcggtggta tattaggtgt atttgtcgca
    10201 gttactcttg ttaagagtat gagtttaact ttactaacat ggttagtcat aattgtgtta
    10261 atctatacgg caattacaat gcttatgcaa ggatttaaaa aagaagcata atgtttgagg
    10321 ggctctttat tacatatatt attgatatgt aatagaggcc cttcgtgtat atatagttag
    10381 aaaaagcgaa agatatgtga taatttatga aaaataaaaa gaaaataagt cttttttcag
    10441 gtgttatgct agctttgagt tcgctaatag gttctggatg gttatttggt tcagaacaag
    10501 cggctaaagt ggcaggacca gccgcaataa tatcttggat tattggggca ataataatga
    10561 tggttattgc ttttaactat gtagaattag gaacaatgtt tcctgaaagt ggaggaatga
    10621 gtaggtttgc tcaatatagt catggttcat ttttaggttt tattgcagca tggggtaatt
    10681 gggtttcttt gattaccttg attccgatag aatcagttgc tgcagttcaa tatatgagtt
    10741 catggccatg gtcttgggca aactggacag ctaaattctt tcatggaagt agtataacaa
    10801 cacaaggatt attaatggtg tacttattta tgattgtatt tacacttatt aatttttggt
    10861 ccgttagaat tttaacgaga tttacaagtt taatctcttt ctttaaattg atagttccga
    10921 cgttaactat aattgtttta ctagttgagg gatgccatcc tggaaatttt ggtcatagtg
    10981 tttctacatt tatgccttat gggacaagtt cgatttttga agcaacgact gtttctggaa
    11041 ttatattatc gtatgatgca tttcagactg ttataaatat gggtggagaa atggagaaac
    11101 cagaaaaaaa tattctacgt gggatagtaa tttctttaac cattaccgct ctaatttata
    11161 tcatgttgca agttacattt ataagtagtg tagacccaag attgattgct agtgtaggtt
    11221 ggaaagggat aagttttaca tctccatttg ctgatattgc aattctattg aatttaaatt
    11281 ggttatccat attactatat acagacgcct ttgtttcacc atttggaaca ggagtagcat
    11341 ttgtagcaac atcagctcgt actttgtctg caatgactaa aaatggtaca gttcctccag
    11401 ttttaggaaa gttaaacaaa aaatacggta tacctagata tgcgatggca gcagatttag
    11461 gcttagcgat gatattagtc tttttcttta gagattggag taaattagct acagttgtat
    11521 caatatcaac ttttatagcc tacttaacag ggccggtatc tgctgtagca cttagaaaac
    11581 ttcgtccaaa ctttaagaga ccatttaaat caaattggct atatatttta gctccagttt
    11641 cttttgtact tacaagtatg gttatatact gggcaatgtg gccaacaact gtagaagtaa
    11701 tttttgttgt attactagga ctaccacttt atttctatta tgaatctaaa aatatgcgaa
    11761 ctacatggaa agaacaatta catggtggtt tgtggatggt agtatattta attttcatct
    11821 cactaatgtc atattttggt agtaaaggat atggtgggaa taacacgata aaatatccaa
    11881 tggatttcgt aatagttata ataggatcat taattattta tgcgtgggca gttgcaagta
    11941 gaatagataa tccagattta gatgatgcgg aaaaattaaa taatactgta aaaagtgaaa
    12001 attaaaaatt acattaaaaa atttttattt atatatatga gtagtagtgt taaaatgata
    12061 gcgtaaacac aattgatatt aggaagtgta tgtagttatg agaaaagtag atgctttagg
    12121 gttggaatgt cctattccag ttgtaaaaac taagaaagct ttggaagaag aagatgttgt
    12181 tgaagttttg gtagataacg atacatctgt aaaaaactta gaaaaaatgg ctaaacaaaa
    12241 ggaatatggc tttaaagttg ataaagaaga aaatcattat aagataacga tatctaaaaa
    12301 taatgatact aaaacaacag ttgaagaaaa acataaaaat gaaaaaatta tgaaatcaac
    12361 aatagaagat ataacattcg aatcgcctaa aggatatatt gtagttatta acacagacag
    12421 tgttggtcat ggtgatgaaa aattaggaaa aattctttta aagagtttca tttattcatt
    12481 aacgggccaa gatgtcttac cagaatacat tctcttatat aatggtggag taaaactaac
    12541 cgttgaagat tcagattctt ttcaagattt aaaagatctt gaagaagctg gggttaaaat
    12601 tatgtcttgt ggtatttgtc ttgactacta cgatttgaaa gataagataa gtgttggtga
    12661 agttacaaat atgtttagaa ttgtagaatt aatgagaact gcaaatagag ttgtaagacc
    12721 ataatttaat aatttagata aaagatgaga atttattttt ttaaaagtct catcttttag
    12781 tctataaaac atatgctcga ggtgactaga tttgaaaaaa caacctttta caatgatagt
    12841 attcaattct actcatgcag ctatagaggc tagtgagatt ttaaaaaata ataagcaggt
    12901 taatagaatt gttaatacac ctggaaaaat tgagaatgga tgtggattaa gtatctatgt
    12961 aaatgatacg gatgtcgata agattacaga acccattcaa agttttttgg atgataaaaa
    13021 ggtaaaagct atttatagcg gtgaaaaaga ggggctatca agaagttata cattaattaa
    13081 ggagatttga tgatgggaat catattagct acggcaggac atgtggatca tggtaaaaca
    13141 actttaataa agaaattaac aggtatagac acagatacta cagaagaaga aaagaagcga
    13201 ggtttaacaa taaatttggg ctttgctcat ttaaaacttc caaataaaag tacaattgga
    13261 attgtagacg ttccaggaca tgaaaaattt ttaaaaaata tgctttctgg tttatcaggt
    13321 atagatgcag ctttattagt agttgatcct aatgaaggtg ttatgccaca aactattgaa
    13381 catgcaagaa tactattgct acttggtgtg actaagttca tagttgtaat tactaaagta
    13441 gatacagttg ataaagatat ggtagagcta gttcatgagg atatcaagga aagttttagt
    13501 ggaacaccga ttgaaaaagc tgagttcttt gatgtagatg cagtaagtgg tacaggagta
    13561 actgacttga tttatgggat acaaaaatta tgttctagca tcgataacac tgatatttct
    13621 ggttatcccc gtttgaatat tgatagatca ttttctttaa aaggtattgg aacagtcgtt
    13681 acaggtactt tacaagatgg gaatctatcc ttagatgaca agttggtcct atatcctcag
    13741 gaaaaagaag taaatattaa aaatattcgt gtatatgaag gaaatacaac ttctgcacaa
    13801 tatagtacaa gaacagcgtt aaatattact ttgccttctg aaactttcca tcgcggtgat
    13861 gcgcttgcaa caccaaacac tatagaagtt gttgatagga taaatgtagt atgtgatatt
    13921 ctttcgatac cagatttgga tttaaaatta aatgatagag tacgtgtata tatgggatct
    13981 aaagaagttt acggaagaat atatccgtta ggtaaaaatg agattatacc tggggaaaca
    14041 aatttcttac aaataagatt ggaagataat atagctgtaa gatatcaaga taaatttatt
    14101 ttaagaagtt attctcctat taaggtgata ggtggaggaa gagtattgga aatgaatcct
    14161 actaataagc gtagatttga ctctgataca cttaagcgac tagaaataag attagaaaat
    14221 aaatgtacag atgtaatttt agaa
//
