LOCUS       c00005_JACKWP0..       17026 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JACKWP010000013.1 Lacticaseibacillus rhamnosus strain CBC-LR1
            29CBC_contig_13, whole genome shotgun sequence.
ACCESSION   JACKWP010000013
VERSION     JACKWP010000013
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 04:52:35
            Original ID  :: JACKWP010000013.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17026
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..17026
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3990:12026]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3991..12026
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..17026
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..17026
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(3..497)
                     /locus_tag="ctg5_1"
                     /transl_table=11
                     /translation="MTKYSSEFKAKVVQEYLSGRLSYKSLCTKYSIPSPKPVREWVKQA
                     QVHGLESLQRKHTKTFYSLEQKLAVVDYYQTSGAGVVSAAAHFGINASQVAVWTKIFKT
                     EGVAGLRPKPRGRRSTVKHKKPKQVKKLELSEKEAYQQEILKLRGELYHTRMERDFLKK
                     LG"
     CDS             complement(592..1947)
                     /locus_tag="ctg5_2"
                     /transl_table=11
                     /translation="MKAKDNQADRGDQPLSEKHHMQIPWYDVIVSEERQADHATLEERA
                     SLVGRVGIMLLACGTGAWRVREAMNTVARALRMSCSADIGLISLSYTCFSNNHAYSEVL
                     SLPKSGVNTDKLDALERFVRHFDKEYATQTVRDIHHRLDQIQKMSGNYDPLRAGLAAAL
                     ACCAFVFLLGGGPIEMICCFVGAGIGNWLREIMIRRNWTLLACIGVSVAVACLVYFIAF
                     RGLEMGLGIAARHEAGYIGAMLFVIPGFPFITSMLDISKQDMRSGMERLLYALMITIVA
                     SLVGWLVAMVVHLRPENFVDLGLSPVLLLVYRLIASFCGVFGFSVMFNSPRRMAIQAGL
                     IGAVANTLRLELVDLNTIPPAAAAFIGALVAGLIASAINRVDGYPRISLTVPSIVIMVP
                     GLYIYRAVYNIGLNNIGVGAEWMTRAALIIMFLPLGLFTARLIMDSRWRQSD"
     CDS             complement(2127..2480)
                     /locus_tag="ctg5_3"
                     /transl_table=11
                     /translation="MDYEEELETKGYIDCLLHELHEQPQLIRQTNIEEVVERTKEEIIR
                     DGFHGYELRRHVFRMILRIDFILTTESVRLSQEGRDAIDELRRIANGQKKEDPRRFLRI
                     WRFLAQRFQHHMQ"
     CDS             complement(2599..3978)
                     /locus_tag="ctg5_4"
                     /transl_table=11
                     /translation="MMDPKKLATTEYYQHRFRNFSTMIIMPSTILFLGLLLFLIFARRE
                     VTVLTAAEIEPVKAAVTVQATAANRIVSNRMKEGKRVKKGETLLVYHDVANPTQIKLLK
                     QQLATLKEQQQQLDVLKQSVTENKDLFSKADRFGYQQQVQDYLSQRRVLTLTAEAEQAT
                     QTVASEKNKEIDRLLSASIQTSQAKMAAISEAKAAIQANKPLPNRHAYHYLYQQYESEI
                     KNTDAEAQANLKRQYLAQLQTQLDEEQTNLTSLEQQRAGQKQADVSAQKAGETQANLTA
                     LQSRLQQTAVAEQTKVQQQVQADEAKLATLNDETQSYHVKASASGVLHLETALEGNQYV
                     PSGSVLARILSDLSEQTDADLKLGVSPTEIMSIKRGQKVRLRIAENVPTPTILDGRVYA
                     IDVAPTRDPKVGNFFTVKARVKLSKSQRQALYYGLAGQASVITGTKTYWDYFADKMFNY
                     R"
     CDS             complement(3991..6183)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 310; E-value: 5.3e-94)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_5"
                     /sec_met_domain="TIGR01193 (E-value: 0.0, bitscore: 1108.4,
                     seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 2e-41, bitscore:
                     133.8, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKYTPKLGQITYYKRFYTAQVDERDCGVAALNMLLKYNGSDYSL
                     AHLRELAKTNQDGTTALGIVRAAEALAFETKPVQADMQLFDFEDVPYPFIAHVLKRGEL
                     LHYYVVFKATRTSILIGDPDPSVRMTWLSREVFEKEWSGVAIFIAPAPQYQPRKEDKGS
                     LFAFVPMLAKQKGIIANIILAAVLITVISIVGSYFLQSIIDTYIPNAMRTTMGMIASGL
                     LVAYLLQAVLTYGQNFLMAVLGQRLAIDVILGYVRHLYELPMSFFSTRRTGEIVSRFAD
                     ANKIIDALANTIMTLFLDVWIVLILGIVLGIQNGTLFLVSLIAVPCYLVIVFAFQRPFD
                     RLNQETMESNAILSSSIIEDLNGIETIKSLTGERVSYERVDREFLTYLKKSFSYTKADQ
                     LQQAIKGLLKLALNVVVLWIGASLVIANRMSLGQMLTFNALLSYFTNPLESIINLQPKL
                     QMARVANNRLNEVYLVESEFKEQRHLTERHLIEGPLRVRDVSFKYGFGQGVLKNVNLEV
                     PENAKYTIVGMSGSGKSTLAKLLVGFYPVDADKGTITFNGIPVKDINLTTLRQYIEYVP
                     QDPFIFSGTVLENLTLGSRSDVSEQDLTQACLVAEIAADIANLPQQWQTKLSESGSILS
                     GGQKQRLAIARALLSPAKVLIFDESTSSLDTITERKIVDRLLAMTDRTIIFVAHRLTIA
                     AKTEQIVVMDHGKIVEQGDHATLLAQDGYYARLVHE"
     CDS             6813..8108
                     /locus_tag="ctg5_6"
                     /transl_table=11
                     /translation="MTVASNITYFFITFPIFATGIYFLTVIFDSRFRVIHITFWSIFGT
                     LLSLLLSTYGEVIFFIIYTCYIVKTTSRSNIFWIFIFMEANLVVITIQSSITQALISAK
                     AHLEPWTLISDSVINLAIIIAIFWLLSNKKEQILKLRDLVQEQNKLQHSVLIYTGATCA
                     SLYCFEATWELIDLNNFLSWLSLGVFLLSVVISLYSIFFILKSYKYYIELIWIKRAESS
                     QRAYYATLAQQQKRTDKLLHDYKNLLATLQLSMDQSTHDISSETRDVVSKAQQALSQVE
                     VNQETFDAIKSDSLKSLLYLKWTEALHQNIKMYVHIEGIIEPLDSSTSFAVIRALGILI
                     DNALEETSRSGNSKFSVLLINSSSYLEVNVINDVTAGFELSNLNQPGFTTKGHGRGKGL
                     TIINELIEQNKKISLKKKVKDNQLKITLFVWR"
     CDS             8113..8889
                     /locus_tag="ctg5_7"
                     /transl_table=11
                     /translation="MSKNKTILNIYILEDNPDYLTFIQETVQQYLLIEELPAKIRLATT
                     SATELLATIDWSAINDSIFLLDIELGDSATSGVDVATAIRKKSYYVDILFITSHVDEAL
                     RILEHKIAPLDMINKNSPSKTEKKIRNNILYAIKRLKARQVASPRLFSYSINSSIFSLD
                     MDELIYIQTAPGVSGTLELHAENEITTFPGNLKELATKYTNLCRCHKSILINPAHVLRL
                     DITNRFVYMDNQDKLEVSIRRMGELRNILTGTRALS"
     CDS             complement(9008..9268)
                     /locus_tag="ctg5_8"
                     /transl_table=11
                     /translation="VNLYYATWLIFLATLFVFKDRKFVKRMISAILDDGNLGFGIRIVI
                     WLALLGLFFVTNHTDWPSAVLILLIVSAVILIDWHKTFQEE"
     CDS             complement(10738..11037)
                     /locus_tag="ctg5_9"
                     /transl_table=11
                     /translation="MNKLKWFAGGNERAEQAIQLIDELLRDFDDSSSHSDRLRTVLRNN
                     REALIHKQAAVPFILSRMNLEISNALLQNNILLTKQQSDKFEQLSSLANIRYGY"
     CDS             complement(11215..11373)
                     /locus_tag="ctg5_10"
                     /transl_table=11
                     /translation="MTKLNEAELSKISGGIGPLVIPVAAILGFLATDAWSHADELVAGV
                     KQGWERS"
     CDS             complement(11841..12026)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_11"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1.7e-08,
                     bitscore: 27.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDHLKTLNTADLASISGGDNGNLWTFIGKAIGSTARSWAEGAMFA
                     PAIGPAKEMVDKFKGN"
     CDS             complement(12086..12271)
                     /locus_tag="ctg5_12"
                     /transl_table=11
                     /translation="MTTRTRLALKEISEEKLEMTTGGNVPLSNCSVDPPNERHPPAYEA
                     AFKYKLPIVHPIKVAT"
     CDS             complement(12663..12848)
                     /locus_tag="ctg5_13"
                     /transl_table=11
                     /translation="MPTRLTKLVDYGLIIATIIFAIYTVTSAIGWTNHGSFVTPMLILM
                     TLLMLLSEREEKQKKA"
     CDS             complement(12898..13704)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_14"
                     /sec_met_domain="Abi (E-value: 2.1e-14, bitscore: 46.6,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERKRHLLLSPGFCVLYILLLVVLISQLLLIPAVYTLKLDFWAGN
                     ILFKAIILLVMIALNWLLLKQAIVLKVTLRRPRLKPVVIWGLLLMLIGWFTVTNRTPID
                     VLQAAVIGTIAAVPEEYLFRGVMLGGLIRAFYVAHHRHAKYQLLFCVGLSSLVFSLAHL
                     SNLPAQGLVITIAQVIQAFGMGAIFAALYIRYGSLLMPILIHFLIDFVITLVSGPYPKE
                     APSDPNAITMTIVHAFLIAGIYLAIALRLFRRGQNNEEFLARLSHS"
     CDS             complement(14025..14465)
                     /locus_tag="ctg5_15"
                     /transl_table=11
                     /translation="MAFSVAFSQALEITAYVNSKSQAQHEDYLSIQKISEMLNIPVPSI
                     KKISSTLKKSGILTSKTGLNGGLRLAKTPQTITVYEILTAIEGTAPLFKLHQGIDPAAF
                     VNGERVTSWLAASTNVLNQAEDAMVQVLKQTSIADLAEAAEA"
     CDS             complement(14520..15947)
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 326.4; E-value:
                     3.7e-99)"
                     /gene_kind="transport"
                     /locus_tag="ctg5_16"
                     /transl_table=11
                     /translation="MSKEEDKELINDGLADDTVIEETDAAITQSQRMSATQVIILGLAL
                     IGAFLGVLDTSIVYTGTVKMAVQLHLNAGALSWVQVAYALTYAGLMLVGGKLGDIYGRK
                     PLFIASLAIFGVGSLAVGAATNALVMISFRAVQGVGAAILAPNCLALLTDTFQGKARQR
                     AIGYYASVIGAGAAVGLVIGGFFATFASWRVGFYMNGPIALIMVGIAVRYLPSAKRQTG
                     KIDWIGTILSVLAMTSISYGLDGSPWPILTLLISAVLWVAFIASQGRVAHPTMPLEIFT
                     DRERMASYVSSLLFSAAAIGFWFYTPQFMQGVLGLTPFMTALGMVPMAILLFIVAVKAR
                     TFVDRWRNSRVMIFGFVTVLLSLAELAVASRFANYWFLLLGTLGFAVGFALAFATLATS
                     GLARIRPEISGAASGVYNTARQFGGALGLAIFAASTASLSKIADVFGQAMLIGVGMTIV
                     GLILVVALIIPAEKAAK"
     CDS             complement(16120..16452)
                     /locus_tag="ctg5_17"
                     /transl_table=11
                     /translation="MNMVQRNQILFILTGLNLSLKQAASGGLMETEAQEVVDEALDILK
                     RPNVLKNRAADYALSRLYARFTRLIGLQGMKLSAEANQWWQAVKDFMENDIHGELSQVG
                     GPHFII"
ORIGIN
        1 gcccctaatt tttttaagaa gtcacgctcc attcgggtat ggtacagttc gccgcgcagt
       61 ttcaggatct cttgctgata agcttccttc tcactaagct caagcttctt aacttgtttg
      121 ggtttcttgt gtttcactgt agaccgcctt cctcgtggtt tcggacgcag cccagccact
      181 ccctcagtct tgaagatctt cgtccagaca gccacctgcg aggcattgat cccgaaatga
      241 gcagccgcag ataccacacc cgcaccactg gtttggtaat agtctaccac ggccagcttc
      301 tgttccagag aataaaatgt cttcgtatgc tttcgctgaa gagattcaag tccatggact
      361 tgggcttgct taacccactc tcggactggt ttcggtgacg ggatactgta tttagtgcaa
      421 aggcttttat aggagagccg tccagaaaga tactcttgta caacctttgc cttgaactca
      481 cttgaatatt tagtcataaa aatgccccac aatcgttaga gtatctgtct aacaattatg
      541 gggcacttca tttgaagtgg ggttatttgt gttgctaaaa agttatactg atcaatcgct
      601 ttgccgccag cgagaatcca taatcaagcg agcggtaaac aagcccagcg gtaaaaacat
      661 aatgataagt gcggcacgcg tcatccattc ggcaccgacg ccaatattat tcaatccaat
      721 attgtaaact gcccggtaaa tatacaagcc aggcaccatg atgacgatgg atggcactgt
      781 tagcgaaatc cgcggatagc catcgacgcg attaatcgcc gacgcaatca gtccggctac
      841 caacgcgccg ataaatgccg ccgcagcagg gggaatcgtg ttgagatcca ccaattcaag
      901 ccgcaacgta ttcgccactg ccccaatcaa cccggcctgg attgccattc ggcgggggct
      961 gttaaacatc accgagaatc cgaagacccc acaaaagctg gcaatgaggc gataaaccaa
     1021 aagaaggacc ggactcaaac ctaagtcgac aaagttttcc gggcgtaaat ggacaaccat
     1081 cgcgaccagc cagccaacca gcgaagccac aatggtaatc atcaacgcat acagtagtcg
     1141 ttccattccc gagcgcatat cctgcttcga aatgtccagc atactggtga taaacgggaa
     1201 acccggaatc acaaacaaca tggcgccgat ataccccgct tcatgccgcg ctgcaatacc
     1261 cagtcccatt tccagtccgc gaaaagcaat aaaataaacc aaacaggcaa ccgccacact
     1321 gacaccgata caagccagca gtgtccagtt acgccgaatc atgatttcac gcagccaatt
     1381 accgatccct gcaccaacaa aacaacagat catttcgata ggaccgccgc ctagcaaaaa
     1441 gacgaaagcg caacacgcca aggctgctgc caatccggcg cgcaacggat cgtaattgcc
     1501 agacattttt tgaatttgat caagtcgatg gtgaatatcc cggacggttt gagtcgcata
     1561 ctctttgtca aaatgacgca caaaacgttc caacgcatcc aacttgtcag tattcacacc
     1621 gctttttggc agtgaaagca cctcagaata ggcatggtta ttgctaaagc aggtatacga
     1681 taaggaaatt aggccaatat ctgctgagca cgacatccgc aatgctcgag caacggtgtt
     1741 catcgcctca cgcacgcgcc acgccccggt accacacgcc agcaacatga tcccgactcg
     1801 gccgacaagt gacgcgcgct cttcaagggt ggcatgatcg gcttgtcgct cttcgctgac
     1861 aatcacgtca taccacggga tctgcatatg atgtttttct gaaagcggtt ggtctccccg
     1921 atccgcttgg ttatcttttg ccttcataac tcgtgctaat ccttcttctt atagggattg
     1981 tctttttcaa aaaaattgaa aataaacatt cactattcta gcacaattca taacagggtg
     2041 tatttttgac tttttgaaac taacggattt gaccgcctta ttcatgacaa gcatgcacaa
     2101 attagcaatc atttctcggt ctcaacttat tgcatatgat gttggaatcg ctgcgccaga
     2161 aaacgccaga ttcgcaaaaa gcgacgggga tcttccttct tctgtccatt ggctatccgt
     2221 cgtagttcgt caattgcatc gcgaccttct tgactcaacc gtacactttc agtcgtgagg
     2281 ataaaatcaa ttcttagtat catccgaaaa acatgtcgtc gtaattcata gccatggaaa
     2341 ccatcgcgga taatctcttc cttggttctt tccacaactt cttcaatatt cgtttggcgg
     2401 atgagctgcg gttgttcatg taattcatgc aacaggcagt cgatatagcc ttttgtttct
     2461 aattcttcct cgtaatccat acgccgatca ccgcctttca tttgactaac ttgatccgca
     2521 tcgttttttt atggtcattt tcttaaataa tgggcatcgc attttcgcta ctaaacgaca
     2581 aaagcggtaa ataccgattc atcgatagtt aaacatctta tctgcaaagt aatcccaata
     2641 agtctttgtg ccggtgataa cagatgcttg accggctaat ccataataaa gggcctgccg
     2701 ctgcgattta gataatttca cccgcgcctt gaccgtaaag aagttgccaa ctttcggatc
     2761 gcgtgtcggg gcgacgtcaa tcgcataaac ccggccatct aatatggtag gggtcggcac
     2821 attctcagca attcgcaggc gtactttctg cccacgcttg atgctcatga tttctgtcgg
     2881 cgaaacaccc aattttaagt cggcatccgt ttgttccgat aagtccgaca gaattcgtgc
     2941 caacacgctt cctgaaggga cgtattgatt cccttccaag gcagtttcta aatgcaaaac
     3001 gccactggca cttgctttga catgatagct ttgagtttca tcattcaagg tagctaactt
     3061 agcctcgtct gcttggacct gttgttgaac cttcgtctgt tccgcaacgg ctgtttgctg
     3121 caaccgactt tgtaatgcgg ttagattagc ctgagtctcc cccgcttttt gagccgatac
     3181 atctgcttgt ttttgaccgg cccgttgctg ctctaaagac gtcaaattgg tttgttcctc
     3241 atccaactgt gtctgtaatt gagcaaggta ctggcgttta aggttcgcct gtgcctccgc
     3301 gtcggtattt tttatctcac tttcatattg ttgataaagg tagtgatagg cgtggcgatt
     3361 gggcaagggt ttgttcgcct gaatcgccgc ttttgcctcg gagatagcgg ccatttttgc
     3421 ttggctcgtt tggatactgg cgcttagtaa ccgatcaatc tctttgtttt tttcactagc
     3481 gacggtttgg gttgcctgct cagcctctgc tgtcagtgtc agcactcggc gttgactcag
     3541 ataatcttgc acctgttgtt gatagccgaa tcggtctgcc tttgaaaaaa gatctttgtt
     3601 ttcggtaaca ctttgtttca aaacatccaa ttgctgctgt tgctctttta gcgttgccag
     3661 ttgctgcttg agtaatttaa tttgtgttgg attggcgaca tcgtggtaaa caagtaaggt
     3721 ctcgcctttc ttcacgcgct tgccttcttt catgcggttc gagacgatcc gattggcggc
     3781 cgtcgcctga accgtcacgg ctgcctttac cggttcaatt tcggcagctg tcagcacagt
     3841 tacctcgcgc cgagcaaaga tcagaaacaa tagcaagcct aagaaaagaa tcgtactagg
     3901 cataataatc attgttgaaa aattgcgaaa gcggtgctgg taatattcgg tcgttgcaag
     3961 ttttttggga tccatcatct aaagctcacc tcactcatga accaggcgcg cgtaataacc
     4021 gtcttgggct aacaacgtcg catggtcacc ttgttccaca attttgccat gatccatcac
     4081 cacaatttgt tcggttttag ccgcaatggt taagcgatgg gcaacaaaaa taatggtccg
     4141 atccgtcatt gccagcaagc gatcgacaat ttttcgctct gtaatggtat ccagactgct
     4201 ggtcgattcg tcaaaaatga gtacttttgc cggtgataac aaggctcgtg caatcgccag
     4261 ccgctgcttc tgaccccctg ataaaatgct gccgctttct gacagtttgg tctgccactg
     4321 ctgcggtaag tttgcgatgt ctgcagcaat ttccgcaacc aaacacgcct gcgtcaagtc
     4381 ttgttccgaa acatccgaac ggctacctaa cgtcaaattc tccaacaccg tccccgaaaa
     4441 aataaatgga tcctgaggta catattcaat atattgccgt aatgttgtga gattaatatc
     4501 tttgaccgga ataccattaa acgtgatggt tcctttatcg gcatcaaccg ggtaaaagcc
     4561 aactaataat tttgctaatg tcgacttacc agaaccgctc atgccgacga tggtatattt
     4621 agcattttcc gggacttcaa ggttgacgtt tttcaacaca ccttggccaa aaccatattt
     4681 aaacgaaaca tcccgaacgc gtaacgggcc ttcgattaaa tgccgctccg tcaagtgccg
     4741 ctgttctttg aattccgatt caaccagata aacctcattc aaacgattgt tagcaacccg
     4801 cgccatttgt aactttggct gtaggttgat gatgctttca agcggattcg taaagtatga
     4861 cagcagcgca ttaaaggtca gcatctgccc caaactcatc cgattggcaa tcaccaaact
     4921 tgccccaatc cacaacacca caacgttcaa cgccagcttc aacagacctt taatcgcttg
     4981 ctgtaattga tctgccttag tgtaactaaa cgatttcttc agataagtta gaaattcccg
     5041 atcaacccgt tcatagctaa ctcgttcgcc ggtcagggac ttgatggttt caatgccatt
     5101 caaatcttca ataatcgatg aactcaagat tgcgttactt tccatcgtct cttggttcaa
     5161 ccgatcaaac ggccgctgaa atgcaaaaac aatcaccaaa taacacggca cggcaatcaa
     5221 tgacactaaa aacaaagtcc cattttggat ccctagaaca atgcctaata ttaggacaat
     5281 ccagacatcc aaaaataacg tcataatcgt attcgccagc gcatcaataa ttttattcgc
     5341 gtccgcaaac cgcgacacaa tctctccggt ccgccgagtt gaaaaaaacg acatcggcaa
     5401 ttcatataaa tggcgcacat accctaaaat gacatcaatc gcaagtcgct gccccaacac
     5461 cgccatcaaa aaattctggc cataagtcaa cacagcttgc agcaagtaag ccaccaaaag
     5521 gccactagca atcatcccca tcgtcgtccg catggcattc ggtatatacg tatcaataat
     5581 agactgcaaa aaatacgacc caacgatact aatgaccgta atcaataccg cggccagaat
     5641 aatgttcgcg atgatgcctt tctgcttagc tagcatgggt acaaacgcaa acaaactgcc
     5701 tttgtcctcc ttacgcggct gatactgcgg cgccggtgca ataaagatgg ccacacccga
     5761 ccattctttt tcaaacacct ctcgcgaaag ccaggtcatg cgcactgacg ggtcaggatc
     5821 gccaatcaga atactcgtgc gcgttgcctt aaaaacaaca taataatgaa gcaattcacc
     5881 acgcttcagc acatgggcaa taaacggata aggcacatcc tcaaaatcaa acaactgcat
     5941 atccgcctgc accggtttcg tctcaaacgc tagtgcttca gcggcccgaa caattcccaa
     6001 agcagtcgtg ccatcctgat ttgtcttcgc taactcgcgc aagtgggcta acgaatagtc
     6061 cgacccattg tatttaagca gcatgtttaa cgcagccaca ccacagtcac gctcgtcaac
     6121 ttgtgcggtg tagaagcgtt tgtagtaggt gatctggcct agttttgggg tgtatttaac
     6181 cattaactct cctcgcttat taagccatta gattcaggcc tcttttatga acttatatgt
     6241 caaaacagtt agccaaagat acaggtgaag tatcgcaaac ttttgcttaa cagctttgat
     6301 ctaagtgtcg taagatttag ttttttgcat ttaaaatatg tggtagtata ttttaaagca
     6361 gataaaatag catataaaaa taaatattca ttttaaaagt acttttatat ttaaatattt
     6421 attcttatat gcttaaagca attatgtgct cagctttttc aaaagacgta tatggcttta
     6481 atgctttctt tgaaactgtt ctatcagcca tttttttata ttttcaaacg cttggcttgt
     6541 tggtcgcaaa ttgccaccat gtatttgtac gagccgctca tccgaaatca cgctgttttt
     6601 catctgactc tgaaacccct ttttgttgtt cacttcaaac tacctcctat gatttattct
     6661 tctgttttta acctaacatg tcgtgagctt tttggggcat acaaaaaata aacgtcgtgt
     6721 tttggccatt taacgtcatt gtgtcagcag atgacgtcat ttatcttcat tcaaaacttg
     6781 ccatactttc ataacttgcg gaggttttct atatgacagt ggcgtcaaac ataacctact
     6841 tctttataac ttttcctatt tttgcgactg gaatttactt tcttaccgtc attttcgaca
     6901 gccgtttcag agttatccac atcacttttt ggtcaatctt cggaaccctt ctgtctttgc
     6961 tcctttcaac ttatggcgag gtcatattct ttataatcta tacgtgctat atagttaaga
     7021 ccacttcacg ttctaatatt ttctggattt ttatctttat ggaagccaac cttgttgtta
     7081 tcacaattca atcctctatt acacaagcct tgatctcagc taaagcacac cttgagcctt
     7141 ggacattaat ttccgactca gttattaact tggcaataat catcgcgatt ttctggttac
     7201 tttctaacaa gaaagagcaa attttaaaac tgcgcgacct agttcaggaa cagaataaac
     7261 tgcaacattc agttctgatc tacacaggcg caacctgtgc gtcactatac tgttttgagg
     7321 ctacttggga gctaatcgat ctcaacaact tcttatcttg gttaagtctt ggcgtattcc
     7381 tactttcagt tgtgatcagc ctttattcaa ttttctttat cttaaaatcc tataaatatt
     7441 atatagagct catctggatt aaacgggcag aaagttccca gcgtgcttac tatgcaacgt
     7501 tagcacagca acaaaagaga acggacaagc tccttcatga ttacaaaaac ttattagcca
     7561 cgttgcagtt gtcaatggat caatcaactc acgacatttc ttctgagacg cgagacgttg
     7621 tttcaaaggc acaacaagcg ctatctcaag tcgaggtcaa tcaagaaacc ttcgatgcaa
     7681 ttaaaagcga ttcgctgaaa agtctactct atttaaaatg gacagaagcg ctacatcaga
     7741 atatcaagat gtacgttcac atcgaaggga tcattgaacc gctcgatagc agcacttcat
     7801 tcgcggtcat tcgcgcactc ggtattttaa ttgacaacgc tttagaagaa acaagccgct
     7861 ccggaaactc aaagtttagt gtcttattaa tcaattcaag ctcgtacctg gaagttaatg
     7921 tcatcaatga cgtgaccgcg ggatttgaac tatcaaatct taaccagcct ggatttacca
     7981 ccaaaggcca tggtcgcgga aaggggttga ccattattaa cgagctgatt gaacaaaaca
     8041 aaaaaatcag ccttaagaaa aaggtcaaag ataaccagtt gaaaatcaca ctttttgtat
     8101 ggaggtaact ttatgtctaa aaacaaaacg atcctaaaca tttatattct cgaagacaac
     8161 cctgactatc taacctttat ccaagaaact gtgcagcagt accttctgat tgaagaacta
     8221 cccgccaaga tccggctggc aacaacgtca gcaaccgaac tgctcgcaac tattgattgg
     8281 tcagccatca acgatagtat cttcctcctt gatatcgagc tgggagattc agcgacaagc
     8341 ggcgtagatg tagccacagc cattcggaaa aagtcatatt atgtcgatat cctcttcatc
     8401 actagccatg tagatgaagc tttaaggatt ttagagcaca aaatcgcacc gttggacatg
     8461 atcaataaga actcaccttc gaagacagaa aagaaaattc gaaataacat tctttatgca
     8521 ataaaacggc taaaggcgcg tcaggtcgca tctcccagat tgtttagcta cagcatcaac
     8581 tccagcattt tttcacttga tatggatgag ctcatctata ttcaaactgc tcccggtgtc
     8641 tcagggacac tggagcttca tgcagaaaat gaaatcacaa cctttcccgg caaccttaag
     8701 gaactagcga ccaaatatac caacttatgt cgatgccata agagtatcct gattaatccc
     8761 gcacatgttt tgcgtctgga catcacaaac cgattcgttt atatggacaa tcaagataaa
     8821 cttgaggtca gtattcggag aatgggcgag ttgcgcaaca tcttaacagg cacacgggct
     8881 ttatcttaag aagagtgtga ctgggcaatc atcctagatt tctgttaatc aacacagctg
     8941 aacgcacaaa taacgcatcc tcaatatcaa gggtgcgtta tttggtggtt tatacaggtt
     9001 ggaaatacta ttcctcctga aaggttttat gccaatcaat taaaattact gcactaacga
     9061 tgagcagtat aaggactgcc gaaggccaat cagtgtgatt tgtgacaaag aaaagcccta
     9121 aaagagccaa ccatatgaca attctgatac caaatcctaa atttccatca tctaaaattg
     9181 cggaaatcat tcttttgaca aatttgcgat ctttgaaaac aaacaaagtt gccaaaaaga
     9241 taagccatgt tgcgtaataa agattcacag tgctactcct tcatcagctc tacttcaacc
     9301 aacgcgctat cgactgaccc gtttgataac cagcgtcata aatccccttt aaaattcccg
     9361 gtgaaaagta ccaaaacgac attattaaaa ccccaatggc gacaagcaac gacactttct
     9421 gttggaatga taatcttgca aattgatcga ttacgctcac ctcgtttaca aacagactta
     9481 tttttacttc tttcagcaat ccattagtaa cctgttcttt atgttctccc accttctaag
     9541 aaaaaggcaa tatactaatg gccaactgca tcaattggga acatttctcc caaaaagatg
     9601 ttcgcgcatg aagccgatgt cttaagaggt ctatcatctg ccagctgatc gcagttacaa
     9661 atacgaatgt gaagaaaaat gccagaatca aaagcataga atataacaca actgtcataa
     9721 gcaaagctcc ttgagtcttc ctttaaactt acattgaggc ggcaaattag cgagcacagg
     9781 ttcggagata ctatacgttc tgctagggtc ggtcatacaa gcaaggagtc acaaaaaatg
     9841 acaccatttt agctatttaa tgctgtttcc taaagccctt ttgctgtcag ggaaaaaaca
     9901 attgttggtt ttgaaagctc atcttgttta gcatctgttc tgccatactc acgcgcaaga
     9961 tctcctgatt tgtatttttg tttcaataca aatcaggaga ccttttgcgg tttttggctg
    10021 atagaacata gggtaacaag attctgacac taaaagcagt ttccaaatat cagtagtgtc
    10081 acctaaaatc tcatttgccg tcatgaacag tcgacattgc attattatgg cctggcagat
    10141 agctgtgtca caatagttgc tgtctctcgg tgctgacagg cttcctactg acaatgacgc
    10201 tgccgcctta ccaatacttc gaaatcaaac aaagaaaatt tgttatttag agcgtttatg
    10261 atctttaacc cttgaagatg cgacacttat tttagaaaaa agaatcaaaa caatgaagat
    10321 tgaaagcatc tcaatgaacg cccggacgat gaaaaaatca aaacccaagc aatcgacaat
    10381 cagcttgttt aagctatcac tgagcgagaa cccgccgaaa aagatacaaa cgataatcca
    10441 gaaagaagct tcattaagcc atgtgtgcat agttttaaga atcgtcatcg tacctccgct
    10501 ttgctcatca ctaaatcatt tatcgaccga tcagttttgg ctctgtcttt ttaagttaga
    10561 ccgttatatt cgaaactagt ttgccaaagt cgccgttata aattggacaa ccttttaggc
    10621 atcatccatt gacaacaagc ccataccaac cagcatcgca atcggagttt gatctgcacc
    10681 aaatgaatca gtgaacctaa ccataatcaa gcgcgctcac cgttttagta gtggcttcta
    10741 gtacccatat ctgatattcg ccagcgaaga aagctgctcg aatttatcag attgttgctt
    10801 ggttaacaaa atattgtttt gcaacagggc attagagatt tctagattca tgcggcttaa
    10861 aataaatgga accgctgctt gcttgtgaat taaggcctct ctattgttcc ttagcactgt
    10921 ccgtaagcga tcactatggg aagaactgtc atcgaagtcg cgaagcagct catcgataag
    10981 ctgtatcgct tgttcagctc gttcattccc gccagcaaac catttcaatt tgttcatcat
    11041 tcactccaaa aaacgttgtg cttgtgcatc ttcacttgta acacgtttgg cgccgtgcat
    11101 tgccagatct gccgtagcaa taacggtaag tgcgtgctcg cccacagata aaaacttgtt
    11161 ctggggagag atacttttac aacggcgaaa tcgctaaaaa tcaacgcacc gttattacga
    11221 tcgttcccat ccttgcttga ccccagctac cagctcatca gcatggctcc acgcatctgt
    11281 tgccagaaat ccaagaatgg cagcgacagg gattacgagc ggtccgatac cgccggaaat
    11341 cttactcaat tcagcttcat tcaacttagt cattaaaatt acccccttgt atttgtagaa
    11401 actactcgcc agttgatcca aaagtccttg ttatggatat cgtggcgata aaacactcat
    11461 caaccgcaca actttttgca aatacaacca ttgagtcatc atcggcatgc ctggattaag
    11521 gccacttgac cttcaccatc gaaattcgac tactggattt gtatggcagc attacagcgt
    11581 acggcttagg cattgaacgg aacactcaaa gtttaagcgt aggtaataaa ccagatggca
    11641 ttcaaaatat aagcacgttt aaaggctatc tgatgcccac tgtcgagata tttatcattc
    11701 ccaacgcgat agtgaccatc ttttttacag cacgtatata ccaaaacacc taatagatat
    11761 accaagataa acgtagctaa cattaaaaga tttatcttat tcatacgttc gcccgttcga
    11821 gtgcctattc atcgcggatg ctaattgcct ttgaacttgt caaccatctc tttggcagga
    11881 ccaatggctg gtgcaaacat ggcgccttca gcccaagaac gcgcggttga accaatagcc
    11941 ttcccgataa aggtccacag attaccatta tcgccaccag aaatgcttgc taagtcagct
    12001 gtgtttaaag tttttaaatg atccatgttt ttcctccttt tttctttatg agcctgtcaa
    12061 tgtattaatc agcccaggtt attgcttaag tcgccacctt aattggatga acaatcggca
    12121 gtttatactt aaatgccgct tcgtaagctg gcggatggcg ttcgtttggt ggatccacac
    12181 tgcaattgga taaaggaaca ttcccaccgg tcgtcatttc aagcttttct tctgagattt
    12241 ctttcaaagc tagccgcgtt cgtgtggtca tcccattttt ctcctttccc tttgttagaa
    12301 ggacttccct tcttcctcat caatataaag tagacagcca ggtttgtggg aatgaatttt
    12361 ttaacgtcga tttttgcaag aaaatcgtcg taaaaaacct aattttgacg tttatcgtta
    12421 aaaacccggc gattatttga tattgccgcc ttctcttcaa aactcaagca actgcaactg
    12481 taactgtatt tacttttacc catgtctttt tcgccactgt gagcatccag tcttaagcca
    12541 acttagaaag gcgatcaggc tcgcggccag catgtgcatc cattcaccgg gaaagtgata
    12601 acaaactgca cacatataac cgacaaaaaa tgttaataaa cagcgccaaa atcttttttg
    12661 attcacgctt tcttctgctt ttcctcccgc tcactcaaca gcatcaacaa cgtcatcaaa
    12721 atcaacattg gcgtcacaaa actgccgtga ttggtccacc caattgccga tgtgaccgta
    12781 taaatggcga aaataatggt agcgattatc aacccataat cgactagttt agtcagtcgc
    12841 gtaggcatcg tttttctcct taaactcgtt ctatcataat tgatacagac agccgcgcta
    12901 cgaatgcgat aaccgtgcca gaaactcttc attgttttgg ccacggcgaa aaagtcgcag
    12961 tgcaatcgct aggtaaatcc cggcaataag gaatgcgtga acaatcgtca tcgttatagc
    13021 gttgggatca ctaggcgctt ctttcggata cggtccacta accaaagtga taacaaaatc
    13081 aatcaaaaaa tggatcaata ttggcataag caacgatccg tagcgaatat aaagtgctgc
    13141 aaaaatagcc cccatgccaa atgcctggat cacttgggca attgttatca caagcccttg
    13201 agcaggcaaa ttactcaggt gagccaatga aaaaaccaag ctgcttaacc ctacgcaaaa
    13261 taagagttgg tatttggcat ggcgatgatg ggcaacataa aacgcccgaa tcaaaccgcc
    13321 aagcatgacg ccacgaaaca aatactcttc tggaacagcg gcaatggtac caatcacagc
    13381 tgcttgcaag acgtcaatcg gtgttcgatt tgtaaccgtg aaccacccga taagcatcaa
    13441 gagcagtccc cagatgacaa ccggcttcaa tcgtggccgc ctaagtgtca ctttcaagac
    13501 gatagcttgt ttcagcagca gccagttaag tgcgatcatc accagtaaaa tgatggcttt
    13561 aaataagata ttcccagccc agaagtccaa tttcagcgtg taaactgctg gaattaaaag
    13621 cagctggctg attagcacaa ccaaaagcaa gatatataaa acgcaaaatc ctggcgacaa
    13681 tagcaaatga cgttttcttt ccatttattc accttcactc gcacgtttca atgcaaagca
    13741 gcttcgatat cgctacccac aatataccga gtcttcgcat gttacggatc attaactttt
    13801 aaacgtcggg ttttcaccga taatcgttgt gttttgaaac ttgacaacgc gttaatcgtc
    13861 cccatttccg aaaaggtcgg caaatggagg cgcacttgct gactatttac tgactgcccc
    13921 acagttgcac gatcctgaaa atgccgtaag caaaatcgcc tcatccaatg ccaacgcgcc
    13981 aacgtcagtc ttggatgagg cgatgaaaag ttagagttcg atatttacgc ttctgcggct
    14041 tcagccaaat cagcaatgct cgtctgcttt agcacttgca ccatagcatc ttcggcttgg
    14101 tttaaaacat tggtgcttgc cgctaaccag ctcgtgacgc gctcgccgtt gacaaacgca
    14161 gctggatcga ttccctgatg aagcttaaat aacggtgccg tcccttcaat agccgttaag
    14221 atttcgtaaa ctgtaatcgt ttgtggcgtt ttggctaatc gcaaaccgcc attgagaccg
    14281 gttttcgacg ttaaaatacc acttttttta agtgtagacg aaattttttt aatgctagga
    14341 accggaatgt ttagcatttc ggaaatcttt tgaattgata aatagtcttc gtgttgtgct
    14401 tgggactttg agttgacata agccgtaatt tcaagtgctt gcgagaatgc gactgaaaaa
    14461 gccatcgaat atacctccca ttaggcgatt gtgtatattc tattatacca atgataccgt
    14521 tacttggcgg ctttttctgc cggaataatg agcgcgacga caagtattaa gccaacaatg
    14581 gtcatgccaa cgccaatcaa cattgcctgt ccgaatacat cggcaatttt agataagctg
    14641 gcggtcgagg ccgcaaaaat tgccagtcct aaagcgccgc caaattgtcg ggcggtgttg
    14701 tagacgcctg atgcagctcc cgaaatttcc ggccgaattc tagccaaacc tgaagtagcg
    14761 agtgtggcaa atgccagcgc gaatcctacc gcaaatccga gtgttccgag taacaaaaac
    14821 cagtaattgg caaaccgtga tgccactgcc agttcagcca atgaaagtag caccgtgaca
    14881 aatccgaaga tcatgaccct tgagttacgc caccgatcaa cgaaggtccg ggccttgact
    14941 gccacaatga acagtaggat ggccattggc accatgccta acgcagtcat aaatggcgtt
    15001 aatcctaaga cgccttgcat aaactgaggt gtgtagaacc aaaagccgat tgcagcggca
    15061 ctaaacaaca gagaactgac ataagaagcc atccgttccc tatccgtaaa gatttccagt
    15121 ggcattgtcg ggtgggcaac gcgaccttga ctagcaatga atgcaaccca aagaactgct
    15181 gaaatcagca acgtgaggat tggccatgga ctgccatcta acccatatga gattgaagtc
    15241 atcgctaata ctgacaagat cgtaccaatc cagtcaatct ttccggtttg gcgttttgca
    15301 ctaggtaaat atcttaccgc aataccaacc atgattaacg cgatcggacc attcatgtag
    15361 aaaccgaccc gccatgacgc aaatgttgca aagaagccgc caatgactaa accaaccgct
    15421 gcaccggctc caatcacaga ggcgtagtag ccaatcgccc gctgccgtgc ttttccttga
    15481 aaggtgtcgg ttaacaatgc taaacagttc ggtgcaagaa tggccgcgcc cacgccttgc
    15541 acagcgcgaa agctaatcat gacaagcgca ttagtagctg ccccgactgc cagactgcca
    15601 accccgaaaa tagctaaact cgcaatgaat aatggcttgc gtccgtatat atcgcctaat
    15661 ttaccgccta ctagcatcag cccagcataa gttagcgcat aggccacctg cacccaagac
    15721 aacgcgccag cattcaaatg caattgtacc gccattttga cggtacctgt gtaaacaatc
    15781 gatgtgtcaa gcacacctag aaaagcccca atcagtgcca gacctaaaat aatgacttga
    15841 gtcgctgaca tgcgctgcga ttgggtgatt gccgcatctg tttcctcaat gacggtgtcg
    15901 tcagccaggc catcattgat taattccttg tcttcttctt tgctcatatg agatgcccct
    15961 ttctatggtt cacttagtat attccgttta tactaatatg gcaaatcttt tttgagcaaa
    16021 aaaaccacgt gttccttaat tctgtggaaa cacgcggcta caagcgaatt cttttcgggc
    16081 cggttactgg aatcagacca tggcttgggc aacaactgtc taaataataa agtgcggccc
    16141 gcctacctga ctcaattcgc catgaatgtc attttccata aagtctttta ccgcctgcca
    16201 ccactgattg gcctctgctg aaagtttcat tccttgcaag ccgattaatc gcgtaaaccg
    16261 tgcgtatagt cgcgacaagg cgtaatctgc ggctcgattc ttgagcacat taggccgctt
    16321 taaaatatct aaggcctcat ccacaacttc ctgtgcttct gtctccatca agccaccact
    16381 agccgcttgt ttcagactca ggtttaatcc ggtcaaaata aacagaatct gatttcgttg
    16441 caccatattc atgagcgatc ctccatgtct ggtagataaa tgtttgcaat gagataatgt
    16501 tttcttgaat tgctaactgc aatataccaa atctatcaag cttcgggtca aactttcgat
    16561 aaacgtcgcc ttttcgccga ttaacgttat tgcggacatg aatcgcccgg tccaaagcac
    16621 atagaaaaag ccgtggtgca ttaaccacga ctaatcggaa gcgcgtattt cagcatagtc
    16681 gtaaaaaggc tgaaatgaca cagttcatca gcatcaaaca aattcatatt ccatccggct
    16741 acttaatgtc cgccacccca gacaattgga aaggcgacga gcccagcagc cagcgcctga
    16801 tcgcgataac gcttggcatt gacctgatct gccggcacat ccgccttgat cgcattgaaa
    16861 atggcgatca tctcgtctgg aatcgtgtga tgaatgagat aatacttgga aatatcatgc
    16921 gatagctggg tcacgactgc gacataagtt gttttatcct ctgcatcttc cagttgtttc
    16981 gcgttggatt cgattatttg ctttaatttg gcatcagctt tcacgg
//
