LOCUS       c00006_JADMYH0..       17084 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JADMYH010000005.1 Lacticaseibacillus rhamnosus strain
            1001311H_170123_H11 NODE_5_length_203294_cov_80.7953, whole genome
            shotgun sequence.
ACCESSION   JADMYH010000005
VERSION     JADMYH010000005
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 04:59:13
            Original ID  :: JADMYH010000005.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 100606
            Orig. end    :: 117690
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..17084
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[105606:112690]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..12084
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..17084
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..17084
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             581..913
                     /locus_tag="ctg6_96"
                     /transl_table=11
                     /translation="MNMVQRNQILFILTGLNLSLKQAASGGLMETEAQEVVDEALDILK
                     RPNVLKNRAADYALSRLYARFTRLIGLQGMKLSAEANQWWQAVKDFMENDIHGELSQVG
                     GPHFII"
     CDS             1086..2513
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 326.9; E-value:
                     2.7e-99)"
                     /gene_kind="transport"
                     /locus_tag="ctg6_97"
                     /transl_table=11
                     /translation="MSKEEDKELINDGLADDTVIEETDAAITQSQRMSATQIIILGLAL
                     IGAFLGVLDTSIVYTGTVKMAAQLHLNAGALSWVQVAYALTYAGLMLVGGKLGDIYGRK
                     PLFIASLAIFGVGSLAVGAATNALVMISFRAVQGVGAAILAPNCLALLTDTFQGKARQR
                     AIGYYASVIGAGAAVGLVIGGFFATFASWRVGFYMNGPIALIMVGIAARYLPSAKRQTG
                     KIDWIGTILSVLAMTSISYGLDGSPWPIPTLLISAVLWVAFIASQGRVAHPTMPLEIFT
                     DRERMASYVSSLLFSAAAIGFWFYTPQFMQGVLGLTPFMTALGMVPMAILLFIVAVKAR
                     TFVDRWRNSKVMIFGFVTVLLSLAELAVASRFANYWFLLLGTLGFAVGFALAFATLATS
                     GLARIRPEISGAASGVYNTARQFGGALGLAIFAASTSSLTKIADVFGQAMLIGVGMTIV
                     GLILVVTLIIPAEKAAK"
     CDS             2568..3008
                     /locus_tag="ctg6_98"
                     /transl_table=11
                     /translation="MAFSVAFSQALEITAYVNAKSQAQHEDYLSIQKISEMLNIPVPSI
                     KKISSTLKKSGILTSKTGLNGGLRLAKTPQTITVYEILTAIEGTAPLFKLHQEIDPAAF
                     VNGERVTSWLTASTNVLNRAEDAMVQVLKQTSIADLAEAAEA"
     CDS             3329..4135
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg6_99"
                     /sec_met_domain="Abi (E-value: 2.4e-14, bitscore: 47.2,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERKRHLLLSPGFCVLYILLLVVLISQLLLIPAVYTLKLDFWAGN
                     ILFKAIILLVMIALNWLLLKQVIVLKVTLSRPRLKPVIIWGLLFILIAWFTVTNRTPID
                     VLQAAVIGTIAAVPEEYLFRGVMLGGLIRAFYVAHHRHAKYQLLFCIGLSSLVFSLAHL
                     SNLPAQGLVITIAQVIQAFGMGAIFAALYIRYGSLLMPILIHFLIDFVITLVSGPYPKE
                     APSDPNAITMTIVHAFLIAGIYLAIALRLFRRGQNNEKFLARLSHS"
     CDS             4185..4370
                     /locus_tag="ctg6_100"
                     /transl_table=11
                     /translation="MSTRLTKLVDYGLIIATIIFAIYTVTSAIGWTNHGSFVTPMLILM
                     TLLMLLSEREEKQKSA"
     CDS             4756..4941
                     /locus_tag="ctg6_101"
                     /transl_table=11
                     /translation="MTMRTGLALKEISGKMLELTSGGNVPLSNCSVDPPNERHPPAYES
                     AFKYKLPIVHPIKVAT"
     CDS             5001..5186
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg6_102"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 2.8e-08,
                     bitscore: 27.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDHLKTLNTADLASISGGDNGNLWTFIGKAIGSTARSWAEGAMFA
                     PAIGPAKEIVDKLNGN"
     CDS             5655..5813
                     /locus_tag="ctg6_103"
                     /transl_table=11
                     /translation="MTKLNEAELSKISGGIGPLAIPVAAILGFLATDAWSHADELVAGV
                     KQGWERS"
     CDS             5992..6291
                     /locus_tag="ctg6_104"
                     /transl_table=11
                     /translation="MKKLKWFSGGNERAEQAIQLIDELLRDFDDSSSHSDRLRTVLRNN
                     REALIYKQAAVPFILSRMNLEISNALLQNNILLTKQQSDKFEQLSSLANIRYGY"
     CDS             7310..7492
                     /locus_tag="ctg6_105"
                     /transl_table=11
                     /translation="MTVVIYSILLILAFFFTFVFVTAIGWQMIDLLRHRLHPRTSFWEK
                     YSQLTQLAISILPFS"
     CDS             complement(8139..8915)
                     /locus_tag="ctg6_106"
                     /transl_table=11
                     /translation="MPKNKTILNIYILEDNPDYLTFIQETVQQYLLIEELPAKIRLATT
                     SATELLAAVDWSAINDSIFLLDIELGDSATSGVDVATAIRRKSYYVDILFITSHVDEAL
                     RILEHKIAPLDMINKNSPSKTEKKIRNNILYAIKRLKARQVASPRLFSYSINSSIFSLE
                     MDELIYIQTAPGVSGTLELHAENEITTFPGNLKELATKYTNLCRCHKSILINPAHVMRL
                     DITNRFVYMDNQDKLEVSIRRMGELRNILTGTRALS"
     CDS             complement(8908..10275)
                     /locus_tag="ctg6_107"
                     /transl_table=11
                     /translation="LAIFRKLTAYKQKGKDYSMIISTDLYYFLFHLPIFLIDLTFLSYI
                     YFNDFKLRHIFLWSLAAGTLSTFLSSVGEITFGILYATNISKKYQRFDIFWVFLFLELN
                     LIVINLQLLVTKIVFLFLSVQSSTISNSIKLIIDVIFAIVMSQVLMKKKLFINSIREQI
                     QKKIAIWRPAVIYLIVTCVSLYCLEFAFSFLEITDILTLLILLTLILFMVINVFSLFFI
                     VKSYQYSLELLVIKHAEASKRAYYSALEQQRINTSRILHDYKNLLATLQLSLQKSSPHH
                     SSDVRTIVTQAQDALQKAEIGKDALALIESDPLRSLLYLKWSESANRGITMYMHTKDTV
                     RSLESDVGFAIIRILGILIDNAIDETATLKLKSFRVLLLPARDHLEIVVANPIPDGFDL
                     TRLNQKGFTTKGSGHGQGMSIINDLIQQNPNISMRKAIINNDQLKITLFIGGKAHA"
     CDS             10397..10531
                     /locus_tag="ctg6_108"
                     /transl_table=11
                     /translation="MKKFKDEEMPMMTDLELSSFVGGMLRDEGFTFNKFKNWLTSIFG"
     CDS             10780..12084
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 59.2; E-value: 5e-18)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg6_109"
                     /sec_met_domain="TIGR01193 (E-value: 8.3e-183, bitscore:
                     603.0, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.3e-41, bitscore:
                     135.1, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFKHTPKLGQITYYKRFYTAQVDERDCGVAALNMLLKYNGSDYSL
                     AHLRELAKTNQDGTTALGIVRAAEALAFETKPVQADMQLFDLEDVPYPFIAHVLKRGEL
                     LHYYVVFKATRTSILIGDPDPSVRMTWLSREVFEKEWSGVAIFIAPAPQYQPRKEDKGS
                     LFAFVPMLAKQKGIIANIILAAVLITVISIVGSYFLQSIIDTYIPNAMRTTMGMIASGL
                     LVAYLLQAVLTYGQNFLMAVLGQRLAIDVILGYVRHLYELPMSFFSTRRTGEIVSRFAD
                     ANKIIDALANTIMTLFLDVWIVLILGIVLGIQNGTLFLVSLIAVPCYLVIVFAFQRPFD
                     RLNQETMESNAILSSSIIEDLNGIETIKSLTGERVSYERVDREFLTYLKRSFSYTKADQ
                     LQQAIKGLLKLALNVVDWGKFGDCQSNEFGADADL"
     CDS             12071..12964
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 218.4; E-value:
                     3.1e-66)"
                     /gene_kind="transport"
                     /locus_tag="ctg6_110"
                     /transl_table=11
                     /translation="MLTFNALLSYFTNPLESIINLQPKLQMARVANNRLNEVYLVESEF
                     KEQRHLTERHLIEGPIRVRDVSFKYGFGQDVLKNINLEVPENAKYTIVGMSGSGKSTLA
                     KLLVGFYPVDADKGTITFNGIPVKDINLTTLRQYIEYVPQDPFIFSGTVLENLTLGSRS
                     DVSEQDLTQACLAAEIAADIANLPQQWQTKLSESGSILSGGQKQRLAIARALLSPAKVL
                     IFDESTSSLDTITERKIVDRLLAMTDRTIIFVAHRLTIAAKTEQIVVMDHGKIVEQGDH
                     ATLLAQDGYYARLVHE"
     CDS             12977..14356
                     /locus_tag="ctg6_111"
                     /transl_table=11
                     /translation="MMDPKKLATTEYYQHRFRNFSTMIIMPSTILFLGLLLFLIFARRE
                     VTVLTAAEIEPVKAAVTVQATAANRIVSNRMKEGKRVKKGETLLVYHDVANPTQIKLLK
                     QQLATLKEQQQQLDVLKQSVTENKDLFSKADRFGYQQQVQDYLSQRRVLTLTAEAEQAT
                     QTVASEKNKEIDRLLSASIQTSQAKMAAISEAKAAIQANKPLASRHAYHYLYQQYESEI
                     KNTDAEAQANLKRQYLAQLQTQLDEEQTNLTSLEQQRAGQKQADVSAQKAGETQANLTA
                     LQSRLQQTAVAEQTKVQQQVQADEAKLATLNDETQNYHVKASASGVLHLETALAGNQYV
                     PSGSVLARILPDLTEQTVADIKLGVSPTEIMSIKRGQKVRLRIAENVPTPTILDGRVYA
                     IDVAPTRDPKVGNFFTVKARVKLSKSQRQSLYYGLAGQASVITGTKTYWDYFADKMFNH
                     R"
     CDS             14474..14827
                     /locus_tag="ctg6_112"
                     /transl_table=11
                     /translation="MDYEEELETKGYIDCLLHELHEQPQLIRQTNIEEVVERTKEEIIR
                     DGFHGYELRRHVFRMILRIDFILTTESVRLSQEGRDAIDELRRIANGQKKEDPRRFLRI
                     RHFLAQRFQHHMQ"
     CDS             15007..16362
                     /locus_tag="ctg6_113"
                     /transl_table=11
                     /translation="MKAKDNQADRGDQPLSEKHHMQIPWYDVIVSEERQADHATLEERA
                     SLVGRVGIMLLACGTGAWRVREAMNTVARALRMSCSADIGLISLSYTCFSNNHAYSEVL
                     SLPKSGVNTDKLDALERFVRHFDKEYATQTVRDIHHRLDQIQKMSGNYDPLRAGLAAAL
                     ACCAFVFLLGGGPIEMVCCFVGAGIGNWLREIMIRRNWTLLACIGVSVAVACLVYFIAF
                     RGLEMGLGIAARHEAGYIGAMLFVIPGFPFITSMLDISKQDMRSGMERLLYALMITIVA
                     SLVGWLVAMVVHLRPENFVDLGLSPVLLLIYRLIASFCGVFGFSVMFNSPRRMAIQAGL
                     IGAVANTLRLELVDLNTIPPAAAAFIGALVAGLIASAINRVDGYPRISLTVPSIVIMVP
                     GLYIYRAVYNIGLNNIGVGAEWMTRAALIIMFLPLGLFTARLIMDSRWRQSD"
ORIGIN
        1 gtccggccgt gaaagctgat gccaaattaa agcaaataat cgaatccaac gcgaaacaac
       61 tggaagatgc agaggacaaa acagcttatg tcgcagtcgt gacccagcta tcgcatgata
      121 tttccaagta ttatctcatt catcacacga ttccagccga gatgatcgcc gttttcaatg
      181 cgatcaaggc ggatgtgcca gcagatcaag tcaatgccaa gcgttatcgc gatcaggcgc
      241 tggctgctgg gctgattgct attccgattg tctggggtgg cgggcattaa ttagccgcat
      301 gggatatgag cttgttcgat gctgatgaac tgtgtcattt cggccttttt acgactatgc
      361 tgaaatacgc gcttccgatt agtcgtggtt aatgcgccac ggctttttct atgcgctttg
      421 gaccgggcga ttcatgtccg caataacgtt aatcggcgaa aaggctacgt ttatcgaaag
      481 tttgacctga agcttgataa atttggtata ttgcagttag caattcaaga aaacgctatc
      541 ttaatgcaaa cacttatcga ccagacatgg aggatcactc atgaatatgg tgcaacgaaa
      601 tcagattctg tttattttga ccggattaaa cctgagtctg aaacaagcgg ctagtggtgg
      661 cctgatggag acagaagcac aggaagttgt agatgaggcc ttagatattt taaagcggcc
      721 taatgtgctc aagaatcgag ccgcagatta cgccttgtcg cgactatacg cacggtttac
      781 gcgattaatc ggcttgcaag gaatgaaact ttcagcggag gccaatcagt ggtggcaggc
      841 ggtaaaagac tttatggaaa atgacattca tggcgaattg agtcaggtag gcgggccgca
      901 ctttattatt tagacagttg ttgcccaagc catggtctga ttccagtaac cggcccgaaa
      961 agaattcgct tgtagccgcg tgtttccata gaattaagga acacgtggtt tttttgctta
     1021 aaaaagattt gccatattag tataaacgga atatactaag tgaaccatag aaaggggcat
     1081 ctcatatgag caaagaagaa gacaaggaat taatcaatga tggcctggct gacgacaccg
     1141 tcattgagga aacagatgcg gcaatcaccc aatcgcagcg catgtcagcg actcaaatca
     1201 ttattttagg gctggcactg attggggctt ttctaggtgt gcttgacaca tcgattgttt
     1261 acacgggtac cgttaaaatg gcggcacaat tgcatttgaa tgctggcgcg ttgtcttggg
     1321 tgcaggtggc ctatgcgcta acttatgctg ggctgatgct agtaggcggt aaattaggcg
     1381 atatttacgg acgcaaacca ttattcattg cgagtttagc tattttcgga gttggcagtc
     1441 tggcagtcgg ggcagctacc aatgcgcttg tcatgattag ctttcgcgct gttcaaggcg
     1501 tgggcgcggc cattcttgca ccgaactgtt tggctttgtt aacagacacc tttcaaggaa
     1561 aagcacgaca gcgggcaatc ggctactatg cttccgtcat tggagccggt gcagcggttg
     1621 gtttagtcat tggcggcttc tttgcaacgt ttgcgtcatg gcgggtcggt ttctacatga
     1681 atggtccgat cgcattaatc atggttggta ttgcggcaag atatttacct agtgcaaaac
     1741 gccaaaccgg aaagattgac tggattggta cgatcttgtc agtattagcg atgacttcaa
     1801 tctcatatgg gttagatggc agtccatggc caatccccac gttgctgatt tcagcagttc
     1861 tttgggttgc attcattgct agtcaaggtc gcgttgccca cccgacaatg ccactggaaa
     1921 tctttacgga tagggaacgg atggcttctt atgtcagttc tctgttgttt agtgccgctg
     1981 caatcggctt ttggttctac acacctcagt ttatgcaagg cgtcttagga ttaacgccat
     2041 ttatgactgc attaggcatg gtgccaatgg ccatcttact cttcattgtg gcagtcaagg
     2101 cccggacctt cgttgatcgg tggcgtaatt caaaggtcat gatcttcgga tttgtcacgg
     2161 tgctactttc attggctgaa ctggcagtgg catcacggtt tgccaattac tggtttttgt
     2221 tacttgggac actcggattt gcggtaggat tcgcgctggc atttgccaca ctcgctactt
     2281 caggtttggc tagaattcgg ccggaaattt cgggagctgc atcaggcgtc tacaacaccg
     2341 cccgacaatt tggcggcgct ttaggactgg caatctttgc ggcgtcaact agcagcttaa
     2401 ctaagattgc ggatgtattc ggacaggcaa tgttgattgg cgtcggcatg accattgttg
     2461 gcctgatact tgtcgtcacg ctcattattc cggcagaaaa agccgccaag taacggtatc
     2521 attggtataa tagaatatac acaatcgttt aatgggaggt atattcgatg gctttttcag
     2581 tcgcattttc gcaagcactt gaaatcacgg cctacgtcaa cgcaaagtcc caagcacaac
     2641 atgaagacta tttatcgatt caaaagattt ccgaaatgct aaacattccg gttcctagca
     2701 ttaaaaaaat ttcgtccaca cttaaaaaaa gtggtatttt aacgtcgaaa accggtctca
     2761 atggcggttt gcgattagcc aaaacgccac aaacgattac agtttatgag atcttaacgg
     2821 caattgaagg gacggcgccg ttatttaagc ttcatcagga aatcgatccg gccgcgtttg
     2881 tcaacggcga gcgcgtcacg agttggttaa cagcaagcac caacgttcta aaccgagccg
     2941 aagatgctat ggtgcaagtg ctaaagcaga cgagcattgc tgatttggct gaagccgcag
     3001 aagcgtaaaa atcgaaatct aacttttcat cgcctcattc aagactaacg ttggcgcgtt
     3061 ggtattggat gaggcgattt tgcttacggc attttcagga tcgtgcaact gtggggcagt
     3121 cagtaaatag tcagcaagtg cgcctccatt ggcaaacctt ttcggaaatg gggacgatta
     3181 acgcgttgtc aagtttcaaa atacaacgat tatcggcgaa aacccgacgt ttaaaagtta
     3241 atgatccgta acatgcgcag cctcggtata ttgtgggtag cgatatcgaa gctgcgttgc
     3301 attgaaacgt gcgagtgaag gtggataaat ggaaagaaaa cgtcatttgc tattgtcgcc
     3361 aggattttgc gttttatata tcttgctttt ggttgtgcta atcagccagc tgcttttaat
     3421 tccagcagtt tacacgctga aattggactt ctgggctggg aatatcttat ttaaagccat
     3481 cattttactg gtgatgatcg cacttaattg gctgttactg aaacaagtta tcgtcttaaa
     3541 agtgacactt agtcgaccac gattgaagcc agttatcatt tggggactgc tctttatact
     3601 tatcgcttgg ttcacggtta caaatcgaac accgattgac gtcttgcaag cagctgtgat
     3661 tggtactatt gccgctgttc ccgaagagta tttgtttcgt ggcgtcatgc ttggcgggtt
     3721 gattcgggcg ttttatgttg cccatcatcg ccatgccaaa taccaactct tattttgcat
     3781 agggttaagc agtcttgttt tttcattggc tcacctgagt aatttgcctg ctcaagggct
     3841 tgtgataaca attgcccaag tgatccaggc atttggcatg ggggctattt ttgcagcact
     3901 ttatattcgt tacggatcgt tgcttatgcc aatattgatc cactttttga ttgattttgt
     3961 tatcactttg gttagtggac cgtatccgaa agaagcgcct agtgatccca acgctataac
     4021 gatgacgatt gttcacgcat tccttattgc cgggatttac ctggcgattg cactgcgact
     4081 ttttcgccgt ggccaaaaca atgaaaagtt tctggcacga ttgtcgcatt cgtaaactgg
     4141 ctgtatgtat caattatgat agaacgagtt taaggagaaa aacgatgtct acgcgactga
     4201 ctaaactagt cgattatggg ttgataatcg ctaccattat ttttgccatt tatacggtca
     4261 catcggcaat tgggtggacc aatcatggga gttttgtgac gccaatgttg attttgatga
     4321 cgttgttaat gctgttaagc gagcgggagg aaaagcagaa gagcgcgtga atcaaaaaag
     4381 attttggcgc tgcttattaa catttattgt cggttatatg tgtgcagttt gtcatcattt
     4441 ccccggcgaa tggatgcaca tgctggccgc gagcctaatc gcctttctaa gttggcttaa
     4501 gactggatgc tcacagtggc gaaaaagaca tgggtaaaag taaatacagt tgcagttgct
     4561 tgagttttga agagaaggcg gcaatatcaa ataatcgccg ggtttttaac gataaacgtc
     4621 aaaattaggt tttttacgac gattttcttg caaaaatcga cgttaaaaaa ttcattccca
     4681 caaacctggc tgtctacttt atattgatgg ggaagaaggg aagtccttct aacaaaggga
     4741 aaggaggaaa atgggatgac catgcgaaca ggactagctt tgaaggaaat ctcgggaaaa
     4801 atgcttgaat tgacgagcgg tgggaatgtt cctttatcca attgcagtgt ggatccacca
     4861 aacgaacgcc atccgccagc ttacgaatcg gcatttaagt ataaactgcc gattgttcat
     4921 ccaattaagg tggcgactta agtgataatt taggctgata gatagattga aaggctcata
     4981 aaggaaaaag gaggaagaac atggatcatt taaaaacttt aaacacggct gatttggcaa
     5041 gtatttctgg tggcgataat ggtaatctgt ggacctttat cgggaaggcc attggttcaa
     5101 ccgcgcgttc ttgggctgaa ggcgccatgt ttgcgccagc cattggtcct gccaaagaga
     5161 ttgttgacaa acttaacggc aattagtatc cgggatgaat aggcactcga acgggcaaac
     5221 gtatgaataa gataaatctt ttaatgttag ctacgtttat cttggtatat ctattaggtg
     5281 ttttggtata tacgtgctgt aaaaaagatg gtcactatcg cgtttggaat gataaatatc
     5341 tcgacagtga gcatcagata gcctttaaac gtgcttatat tttgaatgcc atctggttta
     5401 ttacctacgc ttaaactttg agtgttccgt tcaatgccta agctgtacgc tgtaatgctg
     5461 ccgtacaaac caagtagcag aatttcgatg gtgaaggtca agtgacttta atccaggcat
     5521 gccgctgatg actccatggt tgtatttgca aaaagttgtg cggtagatga gcattttatc
     5581 gccacaatat ccataacaaa gacttttgga tcaactggcg agtagtttct tacaaataca
     5641 aggaggtaat tttaatgact aagttgaatg aagctgaatt gagtaagatt tccggcggta
     5701 tcggaccgct cgcaatccct gtcgctgcta ttcttggatt cctggcaaca gatgcgtgga
     5761 gccatgctga tgagctggtg gcgggagtca agcaaggatg ggaacgatcg taataacggt
     5821 gcgttaattc ttaagcgttg tcgccgttgt aaaagtatct ctgcccagaa caagcctttt
     5881 atctgtgggc gagcatgttc tttctgtcat tgctacggca gatctggcaa tgcacggcgc
     5941 caaacgtgtt acaagtgaag gtgcactagc gcaacttttt tggagtgaaa gatgaagaaa
     6001 ttgaaatggt tttctggtgg gaatgaacgg gctgaacaag cgatacagct tatcgatgaa
     6061 ctgcttcgcg acttcgatga cagttcttcc catagtgatc gcttacggac agtgctaagg
     6121 aacaatagag aggccttaat ttacaagcaa gcagcggttc catttatttt aagccgcatg
     6181 aatctagaaa tctctaatgc cctgttgcaa aacaatatct tgttaaccaa gcaacaatct
     6241 gacaaattcg agcagctttc ttcgctggcg aatatcagat atgggtacta gaggccactc
     6301 ctaaaacggt gagtgcgctt gattatggtt aggctcactg attcatttgg tgcagatcaa
     6361 actccgattg cgatgctggt tggtatgggc ctgttgtcaa tggatgatgc ctaaaaggtt
     6421 gtccatttta taacggcgac gtaggcaaac tagtttcgaa tataacggtc taacttaaaa
     6481 agacagagcc aaaactgatc ggtcgataaa tgatttagtg atgagcaaag cgaaggtacg
     6541 atgacgattc ttaaaactat gcgcacatag cttaatgaag cttctttctg gattatcgtt
     6601 tgtatctgtt tcggcgggtt ttcgctcagt gatgtcttaa acaagctgat tgtcgattgc
     6661 ttgggttttg attttttcat cgtccgggcg ttcatagaga tgctttcaat cttcattgtt
     6721 ttgattcttt tctctaaatt aagtgtcaca tcttcaaagg ttaaagaccg taaacgctct
     6781 aaataacaaa ttttctttgt ttgatttcaa agtattggta aggtggcagt gttattgtca
     6841 gtgggaagcc tgtcatctca aggagacagc aactattgtg acacagccat ctgccaggct
     6901 ataataatgc aatatcggct gttcatgacg gcaaatgaga ttttaggtga cactactgat
     6961 atttgggaac tgtttttagt gtcagaatct tgttacacta tgttcgatca gccaaaaaac
     7021 gcaaaagtct cctgatttgt attgaaacaa aaatacaaat caggagatct tgcgcgtgag
     7081 tatggcagaa ctgatgctaa ataagatgag ctttcaaaac ccacgattgt tttttcttcc
     7141 tgacagtaaa aggcctttcg gaaacaatat taaataggta aaatggcttc atttttgtga
     7201 cttcttactt gtatgatgac cttagcagaa cgtatagtat ctccgaacct gtgctcgcta
     7261 atttgccgct tcaatgtaaa tttaaaggaa gactcaagga gctttgctta tgacagttgt
     7321 gatatattct atacttttga ttctggcatt tttcttcaca ttcgtatttg taactgcgat
     7381 cggctggcag atgatagacc tcttaagaca tcggcttcat ccgcgaacat ctttttggga
     7441 gaaatattcc caattgacgc agttggccat tagtatattg cctttttctt agaaggcggg
     7501 agaacataaa gaacaggtta ctaatggatt actgaaagaa gtaaaaataa gtctgctcgt
     7561 aaacgaggtg agcgtaatcg atcaatttgc aagattatca ttccaacaga aagtgtcgtt
     7621 gcttgttgcc attggggttt taataatggc gttttggtac ttttcaccgg gaattttaaa
     7681 ggggatttat gacgctggtt atcaaacggg tcagtcgata gcacgttggt tgaagtagag
     7741 ctgatgaagg gtagcactgt gaatctttat tacgcaacat ggcttatctt tttggcaact
     7801 ttgtttgttt tcaaagatcg caaatttgtt aaaagaatga tttccgcgat tttagatgat
     7861 ggaagtttag tatttggtat cagaactgtc atatggttgg ctcttttagg gcttttcttt
     7921 gtcacaaatc acactgattg gccttcagca gtccttatac tgctcatcgt tagtgcagta
     7981 attttaattg attggcataa aacctttcag gaggaatagt atttccaacc tgtataaacc
     8041 aaccaaataa cgcatccttg atattgagga tgcgttattt gtgcgttcag ctgtgttgat
     8101 taacagaaat ctaggatgat tgcccagtca cactcttctt aagataaagc tcgtgtgcct
     8161 gttaagatgt tgcgcaactc gcccattctc cgaatactga cctcaagttt atcttgattg
     8221 tccatataaa cgaatcggtt tgtgatgtcc agacgcataa catgtgcggg attaatcagg
     8281 atactcttat ggcatcgaca caagttggta tatttggttg ccagttcctt aaggttgcca
     8341 ggaaaggttg taatttcatt ttctgcatga agctccagtg tccctgagac gccgggagca
     8401 gtttgaatat agatgagctc atccatttca agtgaaaaaa tgctggagtt gatgctgtag
     8461 ctaaacaatc tgggagatgc gacctgacgc gcctttaaac gttttattgc ataaagaatg
     8521 ttatttcgaa ttttcttttc tgtcttcgaa ggtgagttct tgttgatcat gtccaacggt
     8581 gcgattttgt gctctaaaat ccttaaagct tcatctacat ggctggtgat gaagaggata
     8641 tcgacataat atgactttct ccgaatggct gtggctacat ctacgccgct tgtcgctgaa
     8701 tctcccagct cgatatcaag gaggaagata ctatcattga tggctgacca atcgacagct
     8761 gcaagcagtt cagttgctga cgttgttgcc agccggatct tggcgggtag ttcttcaatc
     8821 agaaggtact gctgcacagt ttcttggata aaggttagat agtcagggtt gtcttcgaga
     8881 atataaatgt ttaggattgt tttgttttta ggcatgggct tttcctccta taaatagcgt
     8941 gatctttaat tgatcattgt tgataattgc tttacgcatg ctgatattgg gattttgttg
     9001 gattaggtca ttgataatgg acatgccttg cccgtggcct gagccctttg ttgtaaatcc
     9061 tttttggtta agtcgagtta aatcaaagcc gtcaggaatc gggtttgcaa caacaatttc
     9121 taagtgatcg cgggcgggta ataagagaac tctgaaagac ttaagtttaa gtgtggcagt
     9181 ttcgtcaata gcattatcaa ttaaaatgcc caagattctg ataattgcaa atccgacatc
     9241 actttccagg gatcggactg tatctttggt atgcatgtac attgttatgc cacggtttgc
     9301 agattcggac catttgagat acagcaaact cctgagcgga tcactttcga tcaaagctaa
     9361 ggcatctttg cctatctcag ctttttgaag tgcatcctgt gcttgagtga caatcgttcg
     9421 aacgtctgat gagtggtgtg gtgatgattt ctgcaagcta agctgtaacg ttgcaagtaa
     9481 gtttttgtaa tcatgaagaa tcctactggt attgatacgt tgctgctcaa gggctgaata
     9541 gtacgcgcgt tttgaagctt ccgcgtgctt gataactaac aactccaaag aatactgata
     9601 tgattttacg atgaagaata acgagaatac attgataacc ataaaaagaa ttaaggttaa
     9661 caaaataaga agtgttagga tatcggtgat ttcaagaaat gaaaaagcaa actctaaaca
     9721 gtaaagcgaa acgcaggtca ctattaaata aataactgcc ggtctccaaa tagctatttt
     9781 tttttggatt tgttcacgga tagaattaat gaatagcttc tttttcatta acacctgaga
     9841 catgacaatt gcaaatatga catcaatgat cagcttgatg ctatttgaga tagtggatga
     9901 ttggacagat agaaacagaa atacgatttt agtgactagt aattgaaggt taataacaat
     9961 taagttaagt tctagaaata agaaaaccca gaagatatca aaacgctgat atttttttga
    10021 aatatttgtt gcatataaaa taccaaatgt tatttcacca actgatgaaa gaaatgtgga
    10081 gagcgttcct gcggcgagtg accataagaa aatatgcctg agtttgaagt cgttaaagta
    10141 aatatacgaa aggaaagtaa gatcaatcaa aaagatcggt aagtgaaaca agaagtaata
    10201 caagtctgta gaaataatca tgctataatc tttacctttc tgtttgtagg cggttaactt
    10261 cctaaaaatt gccaaggtgc tcgaaaatct gcgttaaatg gcgaaaaagc tacgtttatt
    10321 ttttgcctaa ccaaaatttt taaagatctg gtacgatcac tttgaacgaa agacaaaacg
    10381 aagggagaaa aaggtaatga aaaaatttaa agatgaggaa atgccaatga tgacagatct
    10441 tgaactttca agttttgttg gcggaatgct ccgagatgaa ggttttacgt ttaacaagtt
    10501 taagaactgg ctaacgagta tctttggcta gttttcttac gtgtgggaga agaacactcg
    10561 taaaagaggt tacaaataat ctcgtattgc gagctacaca atataaaaat tattaaattt
    10621 gcatatattt ataattttta tattaatata actgctatgg ccctcgataa aatgcatgat
    10681 agcacaattt acctagtcaa tatagtgctt ttacttattt tttgttctgg agaggctgat
    10741 gtcaattggc aattcaattt ttaaagtgga gataattaca tgtttaaaca cacccccaaa
    10801 ctaggccaga tcacctacta caaacgcttc tacaccgcac aagttgacga gcgtgactgt
    10861 ggtgtggctg cgttaaacat gctgcttaaa tacaatgggt cggactattc gttagcccac
    10921 ctgcgcgagt tagcgaagac aaatcaggat ggcacgacgg ctttgggaat cgttcgggcc
    10981 gctgaagcac tagcgtttga gacaaaaccg gtacaggcgg atatgcagtt gtttgatctt
    11041 gaggatgtgc cttatccgtt tattgcccat gtgctgaagc gcggtgaatt gcttcattac
    11101 tatgttgttt ttaaagcaac gcgcacgagt attctgattg gcgatcctga cccgtcagtg
    11161 cgcatgacct ggctttcgcg agaggtgttt gaaaaagaat ggtcgggtgt ggccatcttt
    11221 attgcaccgg cgccgcagta tcagccgcgt aaggaggaca aaggcagttt gtttgcgttt
    11281 gtacccatgc tggctaagca aaaaggtatt atcgcgaaca ttattctggc cgcggtattg
    11341 attacggtca ttagtatcgt tgggtcgtat tttttgcagt ctattattga tacgtatata
    11401 ccgaatgcca tgcggacgac gatggggatg attgctagtg gccttttggt ggcttacttg
    11461 ctgcaagctg tgttgactta tggccagaat tttttgatgg cggtgttggg gcagcggctt
    11521 gcgattgatg tcattttagg gtatgtgcgc cacttatatg aattgccgat gtcgtttttt
    11581 tcaactcggc ggaccggaga gattgtgtcg cggtttgcgg atgccaataa aattattgac
    11641 gcgctggcga atacgattat gacgttgttt ttggatgtct ggattgtcct aatattaggc
    11701 attgttctag ggatccaaaa tgggactttg tttttagtgt cattgattgc cgtgccgtgt
    11761 tatttggtga ttgtttttgc atttcagcgg ccgtttgatc ggttgaacca agagacgatg
    11821 gaaagtaacg caatcttgag ttcatcgatt attgaagatt tgaatggcat tgaaaccatc
    11881 aagtccttga ccggcgaacg agttagctat gaacgggttg atcgggaatt tctaacctat
    11941 ttgaagaggt cgtttagtta caccaaggca gatcagttac agcaagcgat taaaggcctg
    12001 ttgaagctgg cgttgaacgt tgtggattgg ggcaagtttg gtgattgcca atcgaatgag
    12061 tttggggcag atgctgacct ttaatgcgct gctgtcatac tttacgaatc cgcttgaaag
    12121 catcatcaac ctacagccaa agttacaaat ggcgcgggtt gctaacaatc gcctgaatga
    12181 agtttatctg gtcgaatcgg aattcaaaga acagcggcac ttgacggagc ggcatttaat
    12241 cgaaggtccg atacgcgttc gggatgtctc gtttaaatat ggttttggcc aagatgtgtt
    12301 aaaaaacatc aaccttgaag tgccggaaaa tgctaaatat accattgtcg gtatgagcgg
    12361 ttctggtaag tcgacattag caaaattatt agttggcttt tacccggttg atgccgataa
    12421 aggaaccatt acgtttaatg gcattccggt caaagacatt aacctgacaa cattacggca
    12481 atatattgaa tatgtacctc aggatccgtt tattttttcg ggcacggtgt tggagaattt
    12541 gacgttaggt agccgttcgg atgtttcgga acaagatttg acgcaggcgt gtttggctgc
    12601 ggaaattgcc gcagacatcg caaacttacc gcagcagtgg cagaccaaat tgtcagaaag
    12661 cggcagcatt ttatcaggcg gtcagaagca gcggctggcg attgcacggg ccttgttgtc
    12721 accggcaaaa gtactgattt ttgacgaatc gaccagcagt ctggatacca ttacagagcg
    12781 aaaaattgtc gatcgcttgc tggcaatgac ggatcggacc attatttttg ttgcccatcg
    12841 cttaactatt gcggctaaaa ccgaacaaat tgtggtgatg gatcatggca aaattgtgga
    12901 acaaggtgac catgcaacgt tgttagccca agacggttat tacgcgcgcc tggttcatga
    12961 gtgaggtgag ctttagatga tggatcccaa aaaacttgca acgaccgaat attaccagca
    13021 ccgctttcgc aatttttcaa cgatgattat tatgcctagt acgattcttt tcttaggctt
    13081 gctattgttt ctgatctttg ctcggcgcga ggtaactgtg ctgacagctg ccgaaattga
    13141 accggtaaag gcagccgtga cagttcaggc gacggccgcc aatcggatcg tctcgaaccg
    13201 catgaaagaa ggcaagcgcg tgaagaaagg cgagacctta cttgtttacc acgatgtcgc
    13261 caatccaaca caaatcaaat tactcaagca gcaactggca acgctaaaag agcaacagca
    13321 gcaattggat gttttgaaac aaagtgttac cgaaaacaaa gatctttttt caaaggcaga
    13381 ccgattcggc tatcaacaac aggtgcaaga ttatctgagt caacggcgag tgctgacact
    13441 gacagcagag gctgagcagg caacccaaac cgtcgctagt gaaaaaaaca aagagattga
    13501 tcggttacta agcgccagta tccaaacgag ccaagcaaaa atggccgcta tctccgaggc
    13561 aaaagcggcg attcaggcga acaaaccctt ggccagtcgc cacgcctatc actaccttta
    13621 tcaacaatat gaaagtgaga taaaaaatac cgacgcggag gcacaggcga accttaaacg
    13681 ccagtacctt gctcaattac agacacagtt ggatgaggaa caaaccaatt tgacgtcttt
    13741 agagcagcaa cgggccggtc aaaaacaagc agatgtatcg gctcaaaaag cgggagagac
    13801 tcaggctaat ctaaccgcat tacaaagtcg gttgcagcaa acagccgttg cggaacagac
    13861 gaaggttcag caacaggtcc aagcagacga ggctaagtta gctaccttga atgatgaaac
    13921 tcaaaactat catgtcaaag caagtgccag tggcgttttg catttagaaa ctgccttggc
    13981 agggaatcaa tacgtccctt caggaagcgt gttggcacga attctgccgg atttaacgga
    14041 acaaacggtt gctgacataa aattaggcgt ttcgccgaca gagatcatga gcatcaagcg
    14101 tgggcagaaa gtacgcctgc gaattgctga gaatgtgccg acccctacca tattagatgg
    14161 ccgggtttat gcgattgacg tcgccccaac acgcgatccg aaagttggta acttctttac
    14221 ggtcaaggcg cgggtgaaat tatctaaatc gcagcggcag tccctttatt atggattagc
    14281 cggccaagca tctgttatca ccggcacaaa gacttattgg gattactttg cagataagat
    14341 gtttaaccat cgataaatcg gtatttaccg cttttgtcgt ttagtagcga aaaggcgatg
    14401 cccattattt aagaaaatga ccataaaaaa cgatacggat caagttaatc aaatgaaagg
    14461 cggtgatcgg cgtatggatt acgaggaaga attagaaaca aaaggctata tcgactgcct
    14521 gttgcatgaa ttacatgaac aaccgcagct catccgccaa acgaatattg aagaagttgt
    14581 ggaaagaacc aaggaagaga ttatccgcga tggtttccat ggctatgaat tacgacggca
    14641 tgtttttcgg atgatactaa gaattgattt tatcctcacg actgaaagtg tacggttgag
    14701 tcaagaagga cgagatgcga ttgatgagct acgaaggatc gccaatggac agaagaagga
    14761 agatccccgt cgctttttgc gaatccggca ttttctggcg cagcgattcc aacatcatat
    14821 gcaataagtt gagaccgaga aatgattgct agtttgtgcg tgcttgtcat gaataaggcg
    14881 gtcaaatccg ttagtttcaa aaagtcaaaa atacaccctg ttatgaattg tgctagaata
    14941 gtgaatgttt attttcaatt tttttggaaa agacaatccc tataagaaga aggattagca
    15001 cgagttatga aggcaaaaga taaccaagcg gatcggggag accaaccgct ttcagaaaaa
    15061 catcatatgc agattccgtg gtatgacgtg attgtcagcg aagagcggca agcggatcat
    15121 gccacccttg aagagcgcgc gtcactcgtc ggccgagtcg ggatcatgtt gctggcgtgt
    15181 ggtaccgggg cgtggcgcgt gcgtgaggcg atgaacaccg ttgctcgagc attgcggatg
    15241 tcatgttcag cagatattgg cctaatttcc ttatcgtata cctgctttag caataaccat
    15301 gcctattctg aggtgctttc actgccaaaa agcggtgtga atactgataa gttggatgcg
    15361 ttggaacgtt ttgtgcgtca ttttgacaaa gagtatgcga ctcaaaccgt ccgggatatt
    15421 caccatcgac ttgatcaaat tcaaaaaatg tctggcaatt acgatccgtt gcgcgccgga
    15481 ttggcagcag ccttggcgtg ttgcgctttc gtctttttgt taggcggcgg tcctatcgaa
    15541 atggtttgtt gttttgttgg tgcagggatc ggtaattggc tgcgtgaaat catgattcgg
    15601 cgtaactgga cactgctggc ttgtatcggt gtcagtgtgg cggttgcctg tttggtttat
    15661 tttatcgctt ttcgcggatt ggaaatggga ctgggcattg cagcgcggca tgaagcgggg
    15721 tatatcggcg ccatgttgtt tgtgattccg ggcttcccgt ttatcaccag tatgctggat
    15781 atttcgaagc aggatatgcg ctcgggaatg gaacgactac tgtatgcgtt gatgattacc
    15841 attgtggctt cgctggttgg ttggctggtc gcgatggttg tccatttacg cccggaaaac
    15901 tttgtcgact taggcttgag tccggtcctt cttttgattt atcgcctcat tgccagcttt
    15961 tgtggggtct tcggattctc ggtgatgttt aacagccccc gccgaatggc aatccaggcc
    16021 gggttgattg gggcagtggc gaatacgttg cggcttgaat tggtggatct caatacgatt
    16081 ccccctgctg cggcggcatt tatcggcgca ctggtggctg ggctgattgc atcggcgatt
    16141 aatcgcgttg atggctatcc gcggatttcg ctaacagtgc catcaatcgt catcatggtg
    16201 cctggcttgt atatttaccg ggcagtttac aatattggat tgaataatat tggcgtcggt
    16261 gccgaatgga tgacgcgtgc cgcacttatc attatgtttt taccgctggg cttgtttacc
    16321 gctcgcttga ttatggattc tcgctggcgg caaagtgatt aattaatatg actttttagc
    16381 aacacaaata accccacttc aaatcggagt gggtttttgt gatggttatg acttgaatcg
    16441 tcaactggaa gtgtgggtgc tttttggtga actcgttagt tgttatgtag caacagcgct
    16501 gttgcagaag aaagctgccg gcagcaacga gttaacgcaa gcatcaaacc aacttggcaa
    16561 gcgtgatcgt catcacactc agatggcttg tacagtcagc ttacacttag ataaatcggt
    16621 gagggggttc atttgacaac cgctcactga ttattagttg actaccactc gtaaccaacc
    16681 ggattcttga tcatgcgctc gtaaacatct ttaacgactg ccatctgatc aggggttaag
    16741 gcaggcattt cggctgcgtc ggtgttacgt tcgatctggg tcgggttgct ggcaccggga
    16801 atgaccgctg aaacggcatc gtacattaga ataaaccgta gtgccgttgc ggccagattg
    16861 tcagatccta accgctcttt tagttcgcgg gctgctttga cgccggttaa atagtcaacg
    16921 ccggagaaag tttcgccttt gctgaagtgt tcgccatggc ggttgttggc gcgctgatct
    16981 gtgggggcaa attgggtctt ttcatcgaac tttccggtca ggaggccgct tgccaagggt
    17041 acccgcgcga gaatgccgac attgtgttgt ttagccagcg ggaa
//
