# emapper version: emapper-2.0.1b-2-g816e190 emapper DB: 2.0 # command: ./emapper.py -i Streptococcus_salivarius/1.contigAnn/FFN/A00000108.ffn --translate --temp_dir Streptococcus_salivarius/4.eggNOG_mapper --output_dir Streptococcus_salivarius/4.eggNOG_mapper --output A00000108 --cpu 36 --keep_mapping_files -m diamond # time: Mon Jul 11 11:31:13 2022 #query_name seed_eggNOG_ortholog seed_ortholog_evalue seed_ortholog_score best_tax_level Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction taxonomic scope eggNOG OGs best eggNOG OG COG Functional cat. eggNOG free text desc. HLLCKODE_00001 1046629.Ssal_01439 3.9e-67 260.8 Bacilli ytxH Bacteria 1VFY7@1239,4HNWV@91061,COG4980@1,COG4980@2 NA|NA|NA S General stress protein HLLCKODE_00002 904306.HMPREF9192_1133 3.7e-08 64.7 Bacilli WQ51_05790 Bacteria 1VAXN@1239,4HM93@91061,COG4768@1,COG4768@2 NA|NA|NA S protein containing a divergent version of the methyl-accepting chemotaxis-like domain HLLCKODE_00003 1046629.Ssal_01442 5.8e-146 523.5 Bacilli lgt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009058,GO:0009059,GO:0009898,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0040007,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0140096,GO:1901564,GO:1901566,GO:1901576 2.1.1.199 ko:K03438,ko:K13292 ko00000,ko01000,ko03009 Bacteria 1TPAK@1239,4HAT0@91061,COG0682@1,COG0682@2 NA|NA|NA M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins HLLCKODE_00004 1046629.Ssal_01443 1.6e-166 592.0 Bacilli hprK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K06023 ko00000,ko01000 Bacteria 1TP5Z@1239,4HAXR@91061,COG1493@1,COG1493@2 NA|NA|NA F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion HLLCKODE_00005 1046629.Ssal_01444 2.2e-41 174.5 Bacilli pspC ko:K03973 ko00000,ko02048,ko03000 Bacteria 1VF0M@1239,4IRAN@91061,COG1983@1,COG1983@2 NA|NA|NA KT PspC domain HLLCKODE_00006 904306.HMPREF9192_1128 0.0 1320.1 Bacilli yhgF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0044424,GO:0044444,GO:0044464,GO:0050896 ko:K06959 ko00000 Bacteria 1TPFE@1239,4HAGY@91061,COG2183@1,COG2183@2 NA|NA|NA K Transcriptional accessory protein HLLCKODE_00008 1046629.Ssal_01448 3.9e-154 550.8 Bacilli XK27_03015 ko:K07089 ko00000 Bacteria 1TQHK@1239,4HB25@91061,COG0701@1,COG0701@2 NA|NA|NA S permease HLLCKODE_00009 904306.HMPREF9192_1125 8.4e-148 529.6 Bacilli ycgQ ko:K08986 ko00000 Bacteria 1V3EX@1239,4HGMG@91061,COG3689@1,COG3689@2 NA|NA|NA S TIGR03943 family HLLCKODE_00010 1046629.Ssal_01450 5.7e-276 956.4 Bacilli sulP GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008272,GO:0008509,GO:0008514,GO:0015075,GO:0015103,GO:0015116,GO:0015138,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015318,GO:0015556,GO:0015698,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015800,GO:0015807,GO:0015810,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070778,GO:0071422,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098656,GO:0098660,GO:0098661,GO:1901682,GO:1902358,GO:1902475,GO:1903825,GO:1905039 ko:K03321 ko00000,ko02000 2.A.53.3 iSbBS512_1146.SbBS512_E1370 Bacteria 1TPI4@1239,4H9V4@91061,COG0659@1,COG0659@2 NA|NA|NA P Sulfate permease and related transporters (MFS superfamily) HLLCKODE_00011 1046629.Ssal_01451 7.6e-101 373.2 Firmicutes Bacteria 1VYAW@1239,2F636@1,33YMH@2 NA|NA|NA HLLCKODE_00012 1046629.Ssal_01453 1.3e-114 419.1 Bacilli estA Bacteria 1V1CQ@1239,4HGVZ@91061,COG2755@1,COG2755@2 NA|NA|NA E GDSL-like Lipase/Acylhydrolase HLLCKODE_00013 1046629.Ssal_01454 4.1e-91 340.9 Bacilli Bacteria 1VBYM@1239,4HM2K@91061,COG1266@1,COG1266@2 NA|NA|NA S CAAX protease self-immunity HLLCKODE_00014 1046629.Ssal_01455 8.8e-49 199.5 Firmicutes Bacteria 1VZAT@1239,2FBVV@1,3440F@2 NA|NA|NA HLLCKODE_00016 1046629.Ssal_01457 1.7e-63 248.4 Bacilli yqeB Bacteria 1V717@1239,2AK1X@1,31ARI@2,4HIQ9@91061 NA|NA|NA S Pyrimidine dimer DNA glycosylase HLLCKODE_00017 435842.HMPREF0848_00317 3.7e-61 240.7 Bacilli ko:K13281 ko00000,ko01000 Bacteria 1VGGK@1239,4HP7S@91061,COG3272@1,COG3272@2 NA|NA|NA S Protein of unknown function (DUF1722) HLLCKODE_00018 1005705.HMPREF9967_0252 2.6e-20 105.1 Streptococcus infantis Bacteria 1TWG1@1239,2DIXF@1,304BM@2,43G59@68892,4I59C@91061 NA|NA|NA M Bacterial lipoprotein HLLCKODE_00019 585203.SMSK564_1364 2.3e-11 74.3 Streptococcus mitis Bacteria 1U4XP@1239,2DKGP@1,2TQDW@28037,309EM@2,4IEP2@91061 NA|NA|NA HLLCKODE_00020 435842.HMPREF0848_00314 6.8e-128 463.4 Bacteria Bacteria COG1266@1,COG1266@2 NA|NA|NA V CAAX protease self-immunity HLLCKODE_00021 888048.HMPREF8577_0358 7.9e-46 189.5 Firmicutes Bacteria 1VAQK@1239,2CUT8@1,32SW2@2 NA|NA|NA HLLCKODE_00022 1123300.AUIN01000009_gene228 3.4e-74 284.6 Bacilli ko:K09017 ko00000,ko03000 Bacteria 1VCGN@1239,4HMEM@91061,COG1309@1,COG1309@2 NA|NA|NA K TetR family transcriptional regulator HLLCKODE_00023 1316408.HSISM1_1770 1.2e-79 302.8 Bacilli Bacteria 1UI83@1239,4HHCN@91061,COG0500@1,COG0500@2 NA|NA|NA Q Methyltransferase domain HLLCKODE_00024 699248.SRA_06236 4.2e-143 514.6 Bacilli acoC 2.3.1.12,2.3.1.61 ko:K00627,ko:K00658 ko00010,ko00020,ko00310,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00310,map00620,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032,M00307 R00209,R02569,R02570,R02571,R08549 RC00004,RC02727,RC02742,RC02833,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1TR5N@1239,4HDFT@91061,COG0508@1,COG0508@2 NA|NA|NA C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex HLLCKODE_00025 388919.SSA_1139 1.3e-174 619.0 Streptococcus sanguinis acoB ko:K21417 ko00000,ko01000 Bacteria 1TP3J@1239,1WR3E@1305,4HAP6@91061,COG0022@1,COG0022@2 NA|NA|NA C dehydrogenase E1 component HLLCKODE_00026 888816.HMPREF9389_1676 3.6e-167 594.3 Streptococcus sanguinis acoA ko:K21416 ko00000,ko01000 Bacteria 1TQDG@1239,1WQRY@1305,4HBEA@91061,COG1071@1,COG1071@2 NA|NA|NA C Acetoin dehydrogenase E1 component subunit alpha HLLCKODE_00027 1123300.AUIN01000017_gene643 2.1e-172 612.1 Bacilli pdhD 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1TP1W@1239,4H9Z5@91061,COG1249@1,COG1249@2 NA|NA|NA C Dehydrogenase HLLCKODE_00028 638301.HMPREF0444_0929 7.8e-10 69.3 Bacilli Bacteria 1VGX4@1239,4HY48@91061,COG3237@1,COG3237@2 NA|NA|NA S CsbD-like HLLCKODE_00029 562981.HMPREF0428_01670 5.5e-31 139.8 Bacilli Bacteria 1VENK@1239,4HNKV@91061,COG2261@1,COG2261@2 NA|NA|NA S Membrane HLLCKODE_00030 1069533.Sinf_1921 1.4e-171 609.0 Bacilli Bacteria 1TRFZ@1239,4HCVP@91061,COG1808@1,COG1808@2 NA|NA|NA S Domain of unknown function (DUF389) HLLCKODE_00031 1069533.Sinf_1920 2.8e-157 561.2 Firmicutes yegS GO:0001727,GO:0003674,GO:0003824,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0030258,GO:0044237,GO:0044238,GO:0044255,GO:0046834,GO:0071704 2.7.1.107 ko:K07029 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 R02240 RC00002,RC00017 ko00000,ko00001,ko01000 Bacteria 1TQ9A@1239,COG1597@1,COG1597@2 NA|NA|NA I Diacylglycerol kinase HLLCKODE_00032 435842.HMPREF0848_00312 2.7e-123 448.0 Bacilli ybbA ko:K07017 ko00000 Bacteria 1V2YF@1239,4IQ46@91061,COG2819@1,COG2819@2 NA|NA|NA S Putative esterase HLLCKODE_00033 435842.HMPREF0848_00311 8.5e-174 616.3 Bacilli fatB ko:K02016 ko02010,map02010 M00240 ko00000,ko00001,ko00002,ko02000 3.A.1.14 Bacteria 1TSDG@1239,4HDG3@91061,COG0614@1,COG0614@2 NA|NA|NA P COG0614 ABC-type Fe3 -hydroxamate transport system, periplasmic component HLLCKODE_00034 435842.HMPREF0848_00310 4.6e-132 477.2 Bacilli fecE 3.6.3.34 ko:K02013 ko02010,map02010 M00240 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 Bacteria 1TP2Q@1239,4HETN@91061,COG1120@1,COG1120@2 NA|NA|NA HP ABC transporter HLLCKODE_00035 435842.HMPREF0848_00309 2.2e-156 558.5 Bacilli fecD ko:K02015 ko02010,map02010 M00240 ko00000,ko00001,ko00002,ko02000 3.A.1.14 Bacteria 1TPX6@1239,4HAUK@91061,COG0609@1,COG0609@2 NA|NA|NA P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily HLLCKODE_00036 435842.HMPREF0848_00308 7.7e-116 423.3 Bacteria Bacteria COG1266@1,COG1266@2 NA|NA|NA V CAAX protease self-immunity HLLCKODE_00037 435842.HMPREF0848_00305 1.5e-147 528.9 Bacteria Bacteria 28KEH@1,2ZA0R@2 NA|NA|NA S Domain of unknown function (DUF4300) HLLCKODE_00038 1046629.Ssal_01469 6.3e-91 340.1 Bacteria tetR Bacteria COG1309@1,COG1309@2 NA|NA|NA K transcriptional regulator HLLCKODE_00039 1046629.Ssal_01470 4.2e-253 880.6 Bacilli norB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 ko:K08170,ko:K08218 ko01501,map01501 M00628,M00702 ko00000,ko00001,ko00002,ko01504,ko02000 2.A.1.25,2.A.1.3.23,2.A.1.3.59 Bacteria 1TPHW@1239,4H9YA@91061,COG0477@1,COG0477@2,COG2211@1,COG2211@2 NA|NA|NA P Major facilitator superfamily HLLCKODE_00040 1123304.AQYA01000034_gene2108 5.4e-21 109.0 Bacilli Bacteria 1UJCN@1239,2DPDJ@1,331MW@2,4HP2C@91061 NA|NA|NA S Domain of unknown function (DUF4767) HLLCKODE_00042 904306.HMPREF9192_1449 8.6e-108 396.4 Bacilli cutC GO:0006873,GO:0006875,GO:0006878,GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0019725,GO:0030003,GO:0042221,GO:0042592,GO:0046688,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0055065,GO:0055070,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0098771 ko:K06201 ko00000 Bacteria 1UYI8@1239,4IR0G@91061,COG3142@1,COG3142@2 NA|NA|NA P Participates in the control of copper homeostasis HLLCKODE_00043 435842.HMPREF0848_00302 1e-99 369.4 Bacilli ypgQ ko:K06950 ko00000 Bacteria 1V7IZ@1239,4HIVB@91061,COG1418@1,COG1418@2 NA|NA|NA F HD superfamily hydrolase HLLCKODE_00044 1046629.Ssal_01477 2.2e-94 351.7 Bacilli XK27_08140 Bacteria 1VGCX@1239,4HRBM@91061,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family HLLCKODE_00045 904306.HMPREF9192_1447 2.1e-149 535.0 Bacilli yitS Bacteria 1V229@1239,4IPK5@91061,COG1307@1,COG1307@2 NA|NA|NA S EDD domain protein, DegV family HLLCKODE_00046 904306.HMPREF9192_1446 1e-202 712.6 Bacilli yeaN GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0071944 ko:K03449 ko00000,ko02000 2.A.1.17 Bacteria 1TP9R@1239,4H9YZ@91061,COG2807@1,COG2807@2 NA|NA|NA P transporter HLLCKODE_00047 435842.HMPREF0848_00298 2.5e-130 471.5 Bacilli Bacteria 1V0BE@1239,4HDZJ@91061,COG4221@1,COG4221@2 NA|NA|NA S Domain of unknown function (DUF4336) HLLCKODE_00048 1316408.HSISM1_1087 1e-131 476.1 Bacilli Bacteria 1UMWY@1239,4HCGN@91061,COG0596@1,COG0596@2 NA|NA|NA S hydrolases or acyltransferases (alpha beta hydrolase superfamily) HLLCKODE_00050 435842.HMPREF0848_00286 0.0 1317.4 Bacilli cadA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.3,3.6.3.5 ko:K01534 ko00000,ko01000 3.A.3.6 Bacteria 1TQ07@1239,4H9SP@91061,COG2217@1,COG2217@2 NA|NA|NA P COG2217 Cation transport ATPase HLLCKODE_00051 435842.HMPREF0848_00285 1.6e-61 241.9 Bacilli smtB ko:K21903 ko00000,ko03000 Bacteria 1VA6G@1239,4HKYT@91061,COG0640@1,COG0640@2 NA|NA|NA K Transcriptional regulator HLLCKODE_00052 435842.HMPREF0848_00284 2.4e-51 208.0 Bacilli zupT ko:K07238 ko00000,ko02000 2.A.5.5 Bacteria 1TP7J@1239,4HB3R@91061,COG0428@1,COG0428@2 NA|NA|NA P Mediates zinc uptake. May also transport other divalent cations HLLCKODE_00053 435842.HMPREF0848_00283 1.9e-77 295.0 Bacilli ko:K07238 ko00000,ko02000 2.A.5.5 Bacteria 1TP7J@1239,4HB3R@91061,COG0428@1,COG0428@2 NA|NA|NA P Mediates zinc uptake. May also transport other divalent cations HLLCKODE_00054 1282665.H353_06488 1.1e-139 502.7 Bacilli Bacteria 1UMWY@1239,4HCGN@91061,COG0596@1,COG0596@2 NA|NA|NA S hydrolases or acyltransferases (alpha beta hydrolase superfamily) HLLCKODE_00055 1046629.Ssal_01490 1.1e-56 225.7 Bacteria Bacteria 2DVV7@1,33XC5@2 NA|NA|NA S ParE toxin of type II toxin-antitoxin system, parDE HLLCKODE_00056 1046629.Ssal_01491 5.3e-44 183.3 Firmicutes Bacteria 1VX2X@1239,2FAP6@1,342WU@2 NA|NA|NA HLLCKODE_00057 638301.HMPREF0444_1312 5.2e-96 357.1 Bacilli Bacteria 1V2YZ@1239,2DBDH@1,2Z8KQ@2,4HK4W@91061 NA|NA|NA HLLCKODE_00058 638301.HMPREF0444_1318 3.4e-97 360.9 Carnobacteriaceae Bacteria 1V1G4@1239,27HT6@186828,4HI02@91061,COG1670@1,COG1670@2 NA|NA|NA J Acetyltransferase (GNAT) domain HLLCKODE_00059 1054460.SPPN_01620 1.5e-36 158.3 Bacteria uvrX 2.7.7.7 ko:K02346,ko:K03502,ko:K14161 ko00000,ko01000,ko03400 Bacteria COG0389@1,COG0389@2 NA|NA|NA L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII HLLCKODE_00060 562983.HMPREF0433_01099 5.9e-55 219.9 Bacilli Bacteria 1VW5E@1239,2DVQU@1,33WU0@2,4HWDN@91061 NA|NA|NA HLLCKODE_00061 1054460.SPPN_01630 8.7e-60 236.1 Bacilli Bacteria 1VFMU@1239,2E59Z@1,33028@2,4HPP8@91061 NA|NA|NA HLLCKODE_00062 1054460.SPPN_01635 1.1e-49 202.2 Bacilli Bacteria 1VFJD@1239,2E660@1,330UP@2,4HPUS@91061 NA|NA|NA HLLCKODE_00063 1203590.HMPREF1481_00525 1e-257 895.6 Bacilli yheS_2 ko:K18231 ko02010,map02010 br01600,ko00000,ko00001,ko01504,ko02000 3.A.1.121.1,3.A.1.121.3 Bacteria 1TQNA@1239,4H9VW@91061,COG0488@1,COG0488@2 NA|NA|NA S ATPase components of ABC transporters with duplicated ATPase domains HLLCKODE_00064 1008453.HMPREF9957_0964 2e-217 761.5 Streptococcus mitis ko:K08217 br01600,ko00000,ko01504,ko02000 2.A.1.21.1,2.A.1.21.22 Bacteria 1UHRM@1239,2TQ4E@28037,4ISTP@91061,COG0477@1,COG0477@2 NA|NA|NA EGP Transmembrane secretion effector HLLCKODE_00065 1008453.HMPREF9957_0963 4.3e-22 109.8 Streptococcus mitis Bacteria 1U4XK@1239,29NGK@1,2TQDT@28037,309EI@2,4IENZ@91061 NA|NA|NA HLLCKODE_00066 411489.CLOL250_02700 2.8e-65 254.6 Clostridiaceae yvbK 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 Bacteria 1V3IC@1239,24HK5@186801,36JMS@31979,COG0454@1,COG0456@2 NA|NA|NA K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases HLLCKODE_00068 1354300.AUQY01000005_gene87 1.5e-52 211.8 Peptoniphilaceae ko:K07343 ko00000 Bacteria 1V42M@1239,22IPD@1570339,24JNV@186801,COG3070@1,COG3070@2 NA|NA|NA K TfoX N-terminal domain HLLCKODE_00069 888833.HMPREF9421_1225 7.6e-101 373.2 Firmicutes Bacteria 1TPRQ@1239,COG4335@1,COG4335@2 NA|NA|NA L DNA alkylation repair enzyme HLLCKODE_00070 999425.HMPREF9186_00017 2.7e-160 571.2 Bacilli aph 2.7.11.1 ko:K08884 ko00000,ko01000,ko01001 Bacteria 1U4B2@1239,4HG90@91061,COG3173@1,COG3173@2 NA|NA|NA KLT Aminoglycoside phosphotransferase HLLCKODE_00071 1035189.HMPREF9954_1212 1.9e-53 214.9 Bacteria ko:K07979 ko00000,ko03000 Bacteria COG1725@1,COG1725@2 NA|NA|NA K Transcriptional regulator HLLCKODE_00072 1035189.HMPREF9954_1211 5.6e-30 136.3 Bacilli Bacteria 1VAMX@1239,2E06M@1,32VUK@2,4HYCN@91061 NA|NA|NA S Protein of unknown function (DUF1648) HLLCKODE_00073 1095727.HMPREF1117_0768 1.4e-255 888.6 Bacilli 6.1.1.6 ko:K01992,ko:K04567 ko00970,map00970 M00254,M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02000,ko03016 3.A.1 Bacteria 1U5FR@1239,4HDGF@91061,COG2898@1,COG2898@2 NA|NA|NA S Psort location CytoplasmicMembrane, score HLLCKODE_00074 1035189.HMPREF9954_1207 8.1e-131 473.0 Streptococcus infantis ecsA ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TQIH@1239,43F8M@68892,4HA2B@91061,COG1131@1,COG1131@2 NA|NA|NA V AAA domain, putative AbiEii toxin, Type IV TA system HLLCKODE_00075 1035189.HMPREF9954_1206 1.3e-105 389.0 Firmicutes Bacteria 1TPXF@1239,COG1309@1,COG1309@2 NA|NA|NA K Transcriptional regulator HLLCKODE_00076 1316408.HSISM1_1563 1.1e-119 436.0 Bacilli ko:K07497 ko00000 Bacteria 1TSET@1239,4HAMH@91061,COG2801@1,COG2801@2 NA|NA|NA L Molecular Function DNA binding, Biological Process DNA recombination HLLCKODE_00077 585204.SMSK597_1867 4.8e-45 186.8 Streptococcus mitis Bacteria 1U4Y6@1239,2TQEJ@28037,4IEPQ@91061,COG2963@1,COG2963@2 NA|NA|NA L transposase activity HLLCKODE_00078 754027.HMPREF9554_00073 2.5e-91 341.7 Spirochaetes Bacteria 2J8C7@203691,COG0500@1,COG2226@2 NA|NA|NA Q Nodulation protein S (NodS) HLLCKODE_00079 435842.HMPREF0848_00282 1e-251 875.5 Bacilli rumA GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070041,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.190 ko:K03215 ko00000,ko01000,ko03009 Bacteria 1TP4H@1239,4HA6M@91061,COG2265@1,COG2265@2 NA|NA|NA J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family HLLCKODE_00080 1046629.Ssal_01496 5.9e-97 360.1 Bacteria mip Bacteria COG2128@1,COG2128@2 NA|NA|NA S hydroperoxide reductase activity HLLCKODE_00081 322159.STER_0700 1.2e-197 695.7 Bacilli Bacteria 1UYHK@1239,4HCT5@91061,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase HLLCKODE_00082 1069533.Sinf_0933 2.9e-152 544.7 Bacteria ydiA ko:K03304,ko:K11041 ko05150,map05150 ko00000,ko00001,ko02000,ko02042 2.A.16,2.A.16.1 Bacteria COG1275@1,COG1275@2 NA|NA|NA P C4-dicarboxylate transporter malic acid transport protein HLLCKODE_00083 904306.HMPREF9192_1382 2e-245 854.7 Bacilli msrR Bacteria 1TSWQ@1239,4HE66@91061,COG1316@1,COG1316@2 NA|NA|NA K Transcriptional regulator HLLCKODE_00084 1046629.Ssal_01508 1.7e-151 542.0 Bacilli pheA GO:0003674,GO:0003824,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 4.2.1.51 ko:K04518 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024 R00691,R01373 RC00360 ko00000,ko00001,ko00002,ko01000 iYO844.BSU27900 Bacteria 1TPDN@1239,4HA96@91061,COG0077@1,COG0077@2 NA|NA|NA E Prephenate dehydratase HLLCKODE_00085 904306.HMPREF9192_1380 1e-79 302.8 Bacilli aroK GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019438,GO:0019632,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615 1.1.1.25,2.7.1.71,4.2.1.10,4.2.3.4 ko:K00014,ko:K00891,ko:K03785,ko:K03786,ko:K13829,ko:K15546 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R02413,R03083,R03084 RC00002,RC00078,RC00206,RC00847,RC00848 ko00000,ko00001,ko00002,ko01000,ko03000 iAPECO1_1312.APECO1_1620,iECOK1_1307.ECOK1_0367,iECS88_1305.ECS88_0383,iUMN146_1321.UM146_15425,iUTI89_1310.UTI89_C0407,iYL1228.KPN_00332 Bacteria 1VA6Z@1239,4HKD6@91061,COG0703@1,COG0703@2 NA|NA|NA F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate HLLCKODE_00086 1046629.Ssal_01510 3.5e-233 813.9 Bacilli aroA GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 1.3.1.12,1.3.1.43,2.5.1.19 ko:K00210,ko:K00220,ko:K00800 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00022,M00025,M00040 R00732,R01728,R03460 RC00125,RC00350 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0345 Bacteria 1TPIH@1239,4HBHZ@91061,COG0128@1,COG0128@2 NA|NA|NA E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate HLLCKODE_00087 904306.HMPREF9192_1378 4.1e-170 604.0 Bacilli ldh 1.1.1.27 ko:K00016 ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922 R00703,R01000,R03104 RC00031,RC00044 ko00000,ko00001,ko01000,ko04147 Bacteria 1UXY2@1239,4HD1S@91061,COG0039@1,COG0039@2 NA|NA|NA C Belongs to the LDH MDH superfamily HLLCKODE_00088 1046629.Ssal_01512 4.2e-53 213.8 Bacilli yheA Bacteria 1VASS@1239,4HPJM@91061,COG3679@1,COG3679@2 NA|NA|NA S Belongs to the UPF0342 family HLLCKODE_00089 904306.HMPREF9192_1376 1.6e-205 721.8 Bacilli tyrA GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.3.1.12,1.3.1.43 ko:K00210,ko:K00220,ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025,M00040 R00732,R01728 RC00125 ko00000,ko00001,ko00002,ko01000 iYO844.BSU22610 Bacteria 1TPXG@1239,4HBI4@91061,COG0287@1,COG0287@2 NA|NA|NA E prephenate dehydrogenase HLLCKODE_00090 904306.HMPREF9192_1375 9.9e-219 765.8 Bacilli aroC GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016491,GO:0016651,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_0976,iNJ661.Rv2540c Bacteria 1TQ40@1239,4HA0H@91061,COG0082@1,COG0082@2 NA|NA|NA E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system HLLCKODE_00091 1046629.Ssal_01515 5.5e-200 703.4 Bacilli aroB 2.7.1.71,4.2.3.4 ko:K01735,ko:K13829 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPKZ@1239,4HAKN@91061,COG0337@1,COG0337@2 NA|NA|NA E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) HLLCKODE_00092 904306.HMPREF9192_1373 7.7e-160 569.7 Bacilli aroE GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQRY@1239,4HD4R@91061,COG0169@1,COG0169@2 NA|NA|NA E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) HLLCKODE_00093 904306.HMPREF9192_1372 3.2e-116 424.5 Bacilli aroD GO:0000166,GO:0003674,GO:0003824,GO:0003855,GO:0004764,GO:0005488,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25,4.2.1.10 ko:K03785,ko:K13832 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413,R03084 RC00206,RC00848 ko00000,ko00001,ko00002,ko01000 Bacteria 1VHVX@1239,4IPJP@91061,COG0710@1,COG0710@2 NA|NA|NA E Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate HLLCKODE_00094 1046629.Ssal_01518 1.3e-213 748.8 Bacilli ywbD 2.1.1.191 ko:K06969 ko00000,ko01000,ko03009 Bacteria 1TRAJ@1239,4HAA1@91061,COG1092@1,COG1092@2 NA|NA|NA J Methyltransferase HLLCKODE_00095 1046629.Ssal_01519 0.0 1301.2 Bacilli ltaS GO:0005575,GO:0005576 2.7.8.20 ko:K01138,ko:K19005 ko00561,ko01100,map00561,map01100 R05081,R10849 RC00017 ko00000,ko00001,ko01000 Bacteria 1TRMA@1239,4H9S0@91061,COG1368@1,COG1368@2 NA|NA|NA M Belongs to the LTA synthase family HLLCKODE_00096 1046629.Ssal_01520 1.3e-24 118.2 Firmicutes WQ51_00785 Bacteria 1W67C@1239,2FKS5@1,34CCP@2 NA|NA|NA HLLCKODE_00110 388919.SSA_0152 1e-123 451.4 Streptococcus sanguinis Bacteria 1V0JC@1239,1WS19@1305,4HAST@91061,COG3505@1,COG3505@2 NA|NA|NA U TraM recognition site of TraD and TraG HLLCKODE_00112 553973.CLOHYLEM_06044 4.2e-22 112.1 Lachnoclostridium ko:K03496 ko00000,ko03036,ko04812 Bacteria 1TP8S@1239,21Y4A@1506553,24AIZ@186801,COG1192@1,COG1192@2 NA|NA|NA D Cellulose biosynthesis protein BcsQ HLLCKODE_00115 1410622.JNKY01000014_gene161 7.2e-24 119.4 unclassified Lachnospiraceae clpC GO:0006950,GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0046688,GO:0050896,GO:0097501,GO:1990169,GO:1990170 ko:K03696 ko01100,map01100 ko00000,ko03110 Bacteria 1TPMU@1239,247TD@186801,27I63@186928,COG0542@1,COG0542@2 NA|NA|NA O C-terminal, D2-small domain, of ClpB protein HLLCKODE_00121 1121864.OMO_01407 6.5e-33 148.3 Enterococcaceae prsA 3.1.3.16,5.2.1.8 ko:K01802,ko:K03769,ko:K07533,ko:K20074 ko00000,ko01000,ko01009,ko03110 Bacteria 1TX3R@1239,4AZPW@81852,4HC85@91061,COG0760@1,COG0760@2 NA|NA|NA M Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins HLLCKODE_00124 337191.KTR9_4843 5.2e-12 79.7 Actinobacteria Bacteria 2AN32@1,2I9X1@201174,31D0N@2 NA|NA|NA HLLCKODE_00126 1214217.ALNF01000060_gene2203 1.8e-13 84.0 Bacteria dnaX 2.4.99.16,2.7.7.7 ko:K02343,ko:K02519,ko:K07114,ko:K16147 ko00230,ko00240,ko00500,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map00500,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378,R09994 RC02795 ko00000,ko00001,ko00002,ko01000,ko02000,ko03012,ko03029,ko03032,ko03400 1.A.13.2.2,1.A.13.2.3 GH13 Bacteria COG3115@1,COG3115@2 NA|NA|NA D cell septum assembly HLLCKODE_00127 1069533.Sinf_1806 9.9e-131 474.6 Bacteria Bacteria COG3087@1,COG3087@2 NA|NA|NA D Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides HLLCKODE_00132 322159.STER_1829 4.1e-65 254.6 Bacilli ko:K07052 ko00000 Bacteria 1VEE2@1239,4HP4A@91061,COG1266@1,COG1266@2 NA|NA|NA S CAAX amino terminal protease family protein HLLCKODE_00133 1215915.BN193_09870 1.4e-83 316.6 Lactococcus xerS GO:0000150,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009987,GO:0015074,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140097,GO:1901360 Bacteria 1V0KQ@1239,1YCQA@1357,4HDPQ@91061,COG4974@1,COG4974@2 NA|NA|NA L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division HLLCKODE_00134 1519999.A0A075LYE4_9CAUD 8.1e-28 131.0 Caudovirales Viruses 4QPCB@28883 NA|NA|NA S protein disulfide oxidoreductase activity HLLCKODE_00135 1123239.KB898632_gene2200 9.5e-16 91.3 Bacilli xerS GO:0000150,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009987,GO:0015074,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140097,GO:1901360 ko:K04763 ko00000,ko03036 Bacteria 1V0KQ@1239,4HDPQ@91061,COG4974@1,COG4974@2 NA|NA|NA L Belongs to the 'phage' integrase family HLLCKODE_00136 862970.SAIN_0151 3.9e-24 118.2 Streptococcus anginosus group Bacteria 1TVY9@1239,29H5Y@1,3043H@2,42EEJ@671232,4I4K4@91061 NA|NA|NA HLLCKODE_00137 1035184.HMPREF1042_2048 9.3e-33 147.1 Streptococcus anginosus group Bacteria 1TVVB@1239,29H4I@1,30423@2,42E7R@671232,4I4DM@91061 NA|NA|NA HLLCKODE_00138 1140001.I571_02850 6.1e-132 478.4 Enterococcaceae traI 5.99.1.2 ko:K03169 ko00000,ko01000,ko03032 Bacteria 1TPJD@1239,4B026@81852,4HAZV@91061,COG0550@1,COG0550@2 NA|NA|NA L DNA topoisomerase HLLCKODE_00141 388919.SSA_0168 2.5e-30 139.8 Streptococcus sanguinis Bacteria 1UAAQ@1239,1WS1U@1305,29RP8@1,30CSJ@2,4IKNH@91061 NA|NA|NA HLLCKODE_00143 1154757.Q5C_01485 4.7e-09 67.8 Leuconostocaceae GO:0001666,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0036293,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0045926,GO:0045927,GO:0046483,GO:0048518,GO:0048519,GO:0050789,GO:0050896,GO:0065007,GO:0070482,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360 Bacteria 1VB8K@1239,4AYI5@81850,4HKT7@91061,COG4679@1,COG4679@2 NA|NA|NA S Phage derived protein Gp49-like (DUF891) HLLCKODE_00144 264199.stu0916 2.1e-49 201.4 Bacteria ko:K15773 ko00000,ko02048,ko03000 Bacteria COG1813@1,COG1813@2 NA|NA|NA K peptidyl-tyrosine sulfation HLLCKODE_00150 904306.HMPREF9192_2011 1.9e-41 176.4 Bacilli comGA ko:K02243,ko:K02244 M00429 ko00000,ko00002,ko02044 3.A.14.1 Bacteria 1TPGE@1239,4HB0C@91061,COG1459@1,COG1459@2,COG2804@1,COG2804@2 NA|NA|NA NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB HLLCKODE_00151 888064.HMPREF9088_2255 1.1e-39 169.9 Enterococcaceae Bacteria 1V1MA@1239,4AZAZ@81852,4ITM8@91061,COG4185@1,COG4185@2 NA|NA|NA S Zeta toxin HLLCKODE_00154 1229517.AMFD01000025_gene932 7.1e-18 97.1 Lactococcus ssb ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 ko00000,ko00001,ko03029,ko03032,ko03400 Bacteria 1V3WT@1239,1YBKM@1357,4HH8I@91061,COG0629@1,COG0629@2 NA|NA|NA L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism HLLCKODE_00158 1123311.KB904459_gene606 1.5e-87 330.9 Bacteria ko:K02395 ko00000,ko02035 Bacteria COG1705@1,COG1705@2 NA|NA|NA NU amidase activity HLLCKODE_00165 888816.HMPREF9389_0702 2.6e-49 203.0 Streptococcus sanguinis Bacteria 1UABH@1239,1WS3H@1305,29RPN@1,30CT3@2,4IKPN@91061 NA|NA|NA S Ribosomal protein S1-like RNA-binding domain HLLCKODE_00168 997830.HMPREF1124_0869 4.7e-24 117.5 Streptococcus infantis Bacteria 1W6YV@1239,2DIDU@1,302XM@2,43GNG@68892,4I5GY@91061 NA|NA|NA S Replication initiator protein A (RepA) N-terminus HLLCKODE_00169 1408322.JHYK01000005_gene536 2.3e-40 172.9 unclassified Lachnospiraceae yhaM ko:K03698 ko00000,ko01000,ko03019 Bacteria 1TPIU@1239,248SS@186801,27J4F@186928,COG3481@1,COG3481@2 NA|NA|NA S Metal dependent phosphohydrolases with conserved 'HD' motif. HLLCKODE_00176 1121864.OMO_01110 1.6e-16 94.4 Enterococcaceae Bacteria 1TRTK@1239,4B39E@81852,4HK3Y@91061,COG0358@1,COG0358@2 NA|NA|NA L Protein of unknown function (DUF3991) HLLCKODE_00180 1123300.AUIN01000009_gene238 4.6e-48 198.0 Bacilli radC ko:K03630 ko00000 Bacteria 1TQ3K@1239,4HB1W@91061,COG2003@1,COG2003@2 NA|NA|NA E Belongs to the UPF0758 family HLLCKODE_00183 1302863.I872_03935 3.9e-08 64.3 Bacilli Bacteria 1W0V8@1239,2DYZ5@1,34BUX@2,4HYKI@91061 NA|NA|NA HLLCKODE_00184 1396.DJ87_5458 1.9e-27 130.6 Bacillus dnaG ko:K02316 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Bacteria 1TZWY@1239,1ZMDD@1386,4I96C@91061,COG0358@1,COG0358@2 NA|NA|NA L DNA primase activity HLLCKODE_00186 1196322.A370_02674 2.2e-122 446.4 Clostridiaceae Bacteria 1TRXF@1239,24ET3@186801,36NWE@31979,COG1479@1,COG1479@2 NA|NA|NA S Protein of unknown function DUF262 HLLCKODE_00187 563038.HMPREF0851_00491 3.2e-201 708.0 Bacilli Bacteria 1TSBG@1239,4HUFT@91061,COG1479@1,COG1479@2 NA|NA|NA S Protein of unknown function DUF262 HLLCKODE_00188 904306.HMPREF9192_1103 4.4e-101 374.0 Bacilli desR ko:K02479,ko:K07693 ko02020,map02020 M00479 ko00000,ko00001,ko00002,ko02022 Bacteria 1TVTF@1239,4HAJW@91061,COG2197@1,COG2197@2 NA|NA|NA K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain HLLCKODE_00189 904306.HMPREF9192_1102 1.1e-190 672.5 Bacilli desK GO:0003674,GO:0003824,GO:0004721,GO:0005488,GO:0005515,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0036211,GO:0042578,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564 2.7.13.3 ko:K07778 ko02020,map02020 M00479 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1TSUE@1239,4HB9N@91061,COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase HLLCKODE_00190 322159.STER_1292 3.8e-131 474.2 Firmicutes yvfS ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1V1AU@1239,COG0842@1,COG0842@2 NA|NA|NA V ABC-2 type transporter HLLCKODE_00191 322159.STER_1293 3.7e-157 560.8 Firmicutes XK27_09825 ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1UZ04@1239,COG1131@1,COG1131@2 NA|NA|NA V 'abc transporter, ATP-binding protein HLLCKODE_00194 435842.HMPREF0848_00894 1.4e-170 605.5 Bacilli fabH 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 1UYNP@1239,4HECC@91061,COG0332@1,COG0332@2 NA|NA|NA I synthase III HLLCKODE_00195 435842.HMPREF0848_00895 1.2e-238 832.0 Bacilli 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 R02539 RC00004,RC00014 ko00000,ko00001,ko01000 Bacteria 1UYWT@1239,4HD2R@91061,COG1541@1,COG1541@2 NA|NA|NA H Coenzyme F390 synthetase HLLCKODE_00196 435842.HMPREF0848_00896 7.3e-152 543.1 Bacilli gumP Bacteria 1V5YS@1239,4HIA8@91061,COG0491@1,COG0491@2 NA|NA|NA S Metallo-beta-lactamase superfamily HLLCKODE_00197 435842.HMPREF0848_00897 1.2e-180 639.0 Bacilli ybjS 1.1.1.133,5.1.3.13 ko:K00067,ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777,R06514 RC00182,RC01531 ko00000,ko00001,ko00002,ko01000 Bacteria 1TT3X@1239,4HFYX@91061,COG0451@1,COG0451@2 NA|NA|NA M NAD dependent epimerase dehydratase family protein HLLCKODE_00198 435842.HMPREF0848_00898 1.3e-232 812.0 Bacilli 2.4.1.276 ko:K14596 ko00906,map00906 R07574 RC00005,RC01992 ko00000,ko00001,ko01000,ko01003 GT1 Bacteria 1V064@1239,4HUGZ@91061,COG1819@1,COG1819@2 NA|NA|NA CG Glycosyltransferase family 28 C-terminal domain HLLCKODE_00199 999425.HMPREF9186_00184 3.3e-109 401.4 Bacteria 1.1.1.105 ko:K07124,ko:K15734 ko00830,map00830 R02124 RC00649 ko00000,ko00001,ko01000 Bacteria COG0300@1,COG0300@2 NA|NA|NA S Belongs to the short-chain dehydrogenases reductases (SDR) family HLLCKODE_00200 888048.HMPREF8577_0487 5e-199 700.3 Bacteria ugcG 2.4.1.80 ko:K00720 ko00600,ko01100,map00600,map01100 M00066 R01497 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko02000 4.D.1.4 GT21 Bacteria COG1215@1,COG1215@2 NA|NA|NA M transferase activity, transferring glycosyl groups HLLCKODE_00201 999425.HMPREF9186_00186 2.4e-105 388.3 Bacteria Bacteria 28MX1@1,2ZB48@2 NA|NA|NA HLLCKODE_00202 1316408.HSISM1_1160 1.3e-208 732.3 Bacteria 2.4.1.276 ko:K14596 ko00906,map00906 R07574 RC00005,RC01992 ko00000,ko00001,ko01000,ko01003 GT1 Bacteria COG1819@1,COG1819@2 NA|NA|NA CG transferase activity, transferring hexosyl groups HLLCKODE_00204 435842.HMPREF0848_00900 6.3e-233 813.1 Bacteria anK3 ko:K07126 ko00000 Bacteria COG0666@1,COG0666@2 NA|NA|NA G response to abiotic stimulus HLLCKODE_00205 435842.HMPREF0848_00901 0.0 1124.8 Bacilli hscC GO:0003674,GO:0003824,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111 ko:K04045 ko00000,ko03110 1.A.33 iECO26_1355.ECO26_0725,iSFV_1184.SFV_0676 Bacteria 1TQ6N@1239,4HCZX@91061,COG0443@1,COG0443@2 NA|NA|NA O Belongs to the heat shock protein 70 family HLLCKODE_00206 1046629.Ssal_00845 5.1e-165 587.0 Bacilli yocS ko:K03453 ko00000 2.A.28 Bacteria 1TP85@1239,4HBG6@91061,COG0385@1,COG0385@2 NA|NA|NA S Transporter HLLCKODE_00207 264199.stu1331 2.2e-81 308.1 Bacilli cdd GO:0003674,GO:0003824,GO:0004126,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006206,GO:0006213,GO:0006216,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008655,GO:0009056,GO:0009058,GO:0009112,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009972,GO:0009987,GO:0016020,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019856,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042455,GO:0043094,GO:0043100,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046087,GO:0046108,GO:0046109,GO:0046112,GO:0046131,GO:0046132,GO:0046133,GO:0046134,GO:0046135,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0047844,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0072529,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659 2.4.2.4,3.5.4.5 ko:K00758,ko:K01489 ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219 R01570,R01878,R02484,R02485,R08221,R08222,R08230 RC00063,RC00074,RC00514 ko00000,ko00001,ko01000 Bacteria 1V58S@1239,4HHTM@91061,COG0295@1,COG0295@2 NA|NA|NA F cytidine deaminase activity HLLCKODE_00208 1046629.Ssal_00843 1.6e-118 432.2 Bacilli yvfS ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1V1AU@1239,4HHQW@91061,COG0842@1,COG0842@2 NA|NA|NA V Transporter HLLCKODE_00209 1046629.Ssal_00842 1.6e-149 535.4 Bacilli XK27_09825 ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1UZ04@1239,4HDGQ@91061,COG1131@1,COG1131@2 NA|NA|NA V abc transporter atp-binding protein HLLCKODE_00210 1123300.AUIN01000013_gene1665 3.1e-15 89.0 Bacteria liaI ko:K11619 ko02020,map02020 M00754 ko00000,ko00001,ko00002 Bacteria COG4758@1,COG4758@2 NA|NA|NA KT membrane HLLCKODE_00211 1123300.AUIN01000013_gene1665 1.2e-30 140.2 Bacteria liaI ko:K11619 ko02020,map02020 M00754 ko00000,ko00001,ko00002 Bacteria COG4758@1,COG4758@2 NA|NA|NA KT membrane HLLCKODE_00212 1046629.Ssal_00839 6.1e-93 346.7 Bacteria XK27_05000 ko:K06940 ko00000 Bacteria COG0727@1,COG0727@2 NA|NA|NA S metal cluster binding HLLCKODE_00213 1046629.Ssal_00838 0.0 1117.1 Bacilli ko:K02004,ko:K19084 ko02010,ko02020,map02010,map02020 M00258,M00731,M00737 ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.134 Bacteria 1TR2D@1239,4H9SH@91061,COG0577@1,COG0577@2 NA|NA|NA V ABC transporter (permease) HLLCKODE_00214 1046629.Ssal_00837 3.2e-133 481.1 Bacilli macB2 ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TNZG@1239,4H9UT@91061,COG1136@1,COG1136@2 NA|NA|NA V ABC transporter, ATP-binding protein HLLCKODE_00215 264199.stu1335 4.6e-161 573.9 Bacilli Bacteria 1TQSG@1239,4HG2J@91061,COG0642@1,COG0642@2 NA|NA|NA T Histidine kinase HLLCKODE_00216 1046629.Ssal_00835 3.5e-123 447.6 Bacilli Bacteria 1TR32@1239,4HAUJ@91061,COG0745@1,COG0745@2 NA|NA|NA KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain HLLCKODE_00217 1046629.Ssal_00834 6.7e-99 366.7 Bacilli xpt GO:0003674,GO:0003824,GO:0006139,GO:0006166,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0043094,GO:0043101,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046128,GO:0046129,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.22,2.4.2.7 ko:K00759,ko:K03816,ko:K09685 ko00230,ko01100,ko01110,map00230,map01100,map01110 R00190,R01229,R02142,R04378 RC00063,RC00122 ko00000,ko00001,ko01000,ko03000,ko04147 iYO844.BSU22070 Bacteria 1V1DU@1239,4HFNW@91061,COG0503@1,COG0503@2 NA|NA|NA F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis HLLCKODE_00218 1046629.Ssal_00833 4.2e-223 780.4 Bacilli pbuX GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006863,GO:0008150,GO:0015205,GO:0015851,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0042906,GO:0042907,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:1904823 ko:K02824,ko:K03458,ko:K16169,ko:K16170 ko00000,ko02000 2.A.40,2.A.40.1.1,2.A.40.1.2,2.A.40.3.1,2.A.40.3.2 iSB619.SA_RS02140 Bacteria 1TNZZ@1239,4HBAM@91061,COG2233@1,COG2233@2 NA|NA|NA F xanthine permease HLLCKODE_00219 1046629.Ssal_00829 8.2e-241 839.3 Bacilli norM GO:0003674,GO:0005215,GO:0006810,GO:0006855,GO:0008150,GO:0015238,GO:0015893,GO:0022857,GO:0042221,GO:0042493,GO:0042891,GO:0042895,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0055085 ko:K03327 ko00000,ko02000 2.A.66.1 Bacteria 1TP5U@1239,4HA4W@91061,COG0534@1,COG0534@2 NA|NA|NA V Multidrug efflux pump HLLCKODE_00221 1046629.Ssal_00827 1.1e-180 639.0 Bacilli msrA 1.8.4.11,1.8.4.12 ko:K07304,ko:K07305,ko:K12267 ko00000,ko01000 Bacteria 1TQ3E@1239,4HAIV@91061,COG0225@1,COG0225@2,COG0229@1,COG0229@2 NA|NA|NA O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine HLLCKODE_00222 1046629.Ssal_00826 2.8e-233 814.3 Bacilli brnQ GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015188,GO:0015190,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015820,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0022857,GO:0034220,GO:0042221,GO:0042493,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903785,GO:1903825,GO:1905039 ko:K03311 ko00000 2.A.26 Bacteria 1TQIS@1239,4HAKA@91061,COG1114@1,COG1114@2 NA|NA|NA E Component of the transport system for branched-chain amino acids HLLCKODE_00223 904306.HMPREF9192_1083 1.7e-181 641.7 Bacilli manA 5.3.1.8 ko:K01809 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01819 RC00376 ko00000,ko00001,ko00002,ko01000 Bacteria 1VRGI@1239,4HBFW@91061,COG1482@1,COG1482@2 NA|NA|NA G mannose-6-phosphate isomerase HLLCKODE_00224 1046629.Ssal_00824 1.8e-59 235.3 Bacilli Bacteria 1VGVI@1239,2C9NT@1,32V8Q@2,4IRUI@91061 NA|NA|NA S Protein of unknown function (DUF3290) HLLCKODE_00225 1046629.Ssal_00823 1.5e-107 395.6 Bacilli Bacteria 1UYR2@1239,4HGVG@91061,COG2323@1,COG2323@2 NA|NA|NA S Protein of unknown function (DUF421) HLLCKODE_00226 1046629.Ssal_00822 1.4e-16 91.7 Bacilli csbD Bacteria 1VN9B@1239,4I22P@91061,COG3237@1,COG3237@2 NA|NA|NA S CsbD-like HLLCKODE_00227 1046629.Ssal_00820 1.9e-116 427.2 Bacilli Bacteria 1TQ1J@1239,2Z8AD@2,4HDNN@91061,arCOG08054@1 NA|NA|NA S Carbohydrate-binding domain-containing protein Cthe_2159 HLLCKODE_00228 435842.HMPREF0848_01140 5.2e-51 207.2 Bacilli XK27_01300 Bacteria 1V6S0@1239,4HKKR@91061,COG4405@1,COG4405@2 NA|NA|NA P Protein conserved in bacteria HLLCKODE_00229 322159.STER_1318 7.1e-224 783.1 Bacilli yfnA ko:K03294 ko00000 2.A.3.2 Bacteria 1TQ4K@1239,4HA66@91061,COG0531@1,COG0531@2 NA|NA|NA E amino acid HLLCKODE_00230 1046629.Ssal_00817 0.0 1660.2 Bacteria Bacteria COG5263@1,COG5263@2 NA|NA|NA S dextransucrase activity HLLCKODE_00231 1046629.Ssal_00816 2.4e-136 491.5 Bacilli tcyC2 3.6.3.21 ko:K02028,ko:K10010,ko:K16960 ko02010,map02010 M00234,M00236,M00585 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.10,3.A.1.3.13,3.A.1.3.14 Bacteria 1TNYD@1239,4H9WY@91061,COG1126@1,COG1126@2 NA|NA|NA E abc transporter atp-binding protein HLLCKODE_00232 1046629.Ssal_00815 6.2e-112 410.2 Bacilli yxeN ko:K02029,ko:K16959,ko:K16962 ko02010,map02010 M00236,M00585,M00586 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.13 Bacteria 1V1PT@1239,4HI18@91061,COG0765@1,COG0765@2 NA|NA|NA P ABC transporter, permease protein HLLCKODE_00233 435842.HMPREF0848_00931 1e-109 402.9 Bacilli ytmL ko:K02029,ko:K10009,ko:K16958,ko:K16959 ko02010,map02010 M00234,M00236,M00585 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.10,3.A.1.3.13,3.A.1.3.14 Bacteria 1V4Q3@1239,4HDVS@91061,COG0765@1,COG0765@2 NA|NA|NA P ABC transporter (Permease HLLCKODE_00234 1046629.Ssal_00813 1.8e-164 585.1 Bacilli ko:K02030,ko:K16957 ko02010,map02010 M00236,M00585 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.13 Bacteria 1UX4B@1239,4HG72@91061,COG0834@1,COG0834@2 NA|NA|NA ET ABC transporter substrate-binding protein HLLCKODE_00235 1046629.Ssal_00812 4e-176 624.0 Bacilli 4.1.1.37 ko:K01599,ko:K16957 ko00860,ko01100,ko01110,ko02010,map00860,map01100,map01110,map02010 M00121,M00585 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3.13 Bacteria 1TNYE@1239,4HQ5B@91061,COG0407@1,COG0407@2 NA|NA|NA H Uroporphyrinogen decarboxylase (URO-D) HLLCKODE_00236 435842.HMPREF0848_00934 2.7e-85 321.2 Bacilli btuE 1.11.1.9 ko:K00432 ko00480,ko00590,ko04918,map00480,map00590,map04918 R00274,R07034,R07035 RC00011,RC00982 ko00000,ko00001,ko01000 Bacteria 1V3M3@1239,4HH5Q@91061,COG0386@1,COG0386@2 NA|NA|NA O Belongs to the glutathione peroxidase family HLLCKODE_00237 435842.HMPREF0848_00935 1.5e-42 178.3 Bacilli ko:K15383 ko00000,ko02000 9.A.58.2 Bacteria 1VBI9@1239,4HN2M@91061,COG4095@1,COG4095@2 NA|NA|NA S Sugar efflux transporter for intercellular exchange HLLCKODE_00238 888833.HMPREF9421_1062 4e-204 717.2 Bacilli ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TSN2@1239,28K0P@1,2Z9QJ@2,4HU6K@91061 NA|NA|NA P FtsX-like permease family HLLCKODE_00239 999425.HMPREF9186_00599 2.3e-122 444.9 Bacilli ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 1U3WD@1239,4HV7M@91061,COG1136@1,COG1136@2 NA|NA|NA V abc transporter atp-binding protein HLLCKODE_00240 888746.HMPREF9180_0402 1.8e-96 358.6 Bacilli Bacteria 1V2BY@1239,4HPW3@91061,COG1309@1,COG1309@2 NA|NA|NA K WHG domain HLLCKODE_00241 435842.HMPREF0848_00939 1.8e-170 605.1 Bacilli ydhF Bacteria 1TQ12@1239,4HA57@91061,COG4989@1,COG4989@2 NA|NA|NA S Aldo keto reductase HLLCKODE_00242 1114965.Spaf_1395 2.1e-211 741.5 Bacilli natB ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TXRK@1239,4HC9K@91061,COG1668@1,COG1668@2 NA|NA|NA CP ABC-type Na efflux pump, permease component HLLCKODE_00243 1316408.HSISM1_1676 8.3e-165 586.3 Bacilli natA ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TR06@1239,4H9RX@91061,COG4152@1,COG4152@2 NA|NA|NA S abc transporter atp-binding protein HLLCKODE_00244 888821.HMPREF9394_1732 5.2e-09 68.6 Streptococcus sanguinis Bacteria 1UA4A@1239,1WRFP@1305,29RIY@1,30CN1@2,4IKE5@91061 NA|NA|NA S Protein of unknown function (DUF3169) HLLCKODE_00245 435842.HMPREF0848_00944 5.5e-27 126.3 Bacilli XK27_07105 ko:K07729 ko00000,ko03000 Bacteria 1VEZ1@1239,4HNNM@91061,COG1476@1,COG1476@2 NA|NA|NA K transcriptional HLLCKODE_00246 435842.HMPREF0848_00945 1.3e-35 155.6 Firmicutes Bacteria 1VQQU@1239,2DU7U@1,33P99@2 NA|NA|NA HLLCKODE_00247 1046629.Ssal_00795 2.2e-108 398.3 Bacilli XK27_02070 ko:K07078 ko00000 Bacteria 1V1CR@1239,4HD6W@91061,COG3560@1,COG3560@2 NA|NA|NA S nitroreductase HLLCKODE_00248 435842.HMPREF0848_00947 6.5e-151 540.0 Bacilli 1.13.11.2 ko:K07104 ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220 M00569 R00816,R04089,R05295,R05404,R05406,R07795 RC00387,RC00643,RC01075,RC01364,RC01914 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPRF@1239,4HAE7@91061,COG2514@1,COG2514@2 NA|NA|NA S glyoxalase HLLCKODE_00249 904306.HMPREF9192_1076 8.9e-75 286.2 Bacilli ywnA Bacteria 1V6FK@1239,4HKZD@91061,COG1959@1,COG1959@2 NA|NA|NA K Transcriptional regulator HLLCKODE_00250 904306.HMPREF9192_1075 1.2e-152 545.8 Bacilli Bacteria 1V13S@1239,4HENM@91061,COG4814@1,COG4814@2 NA|NA|NA E Alpha/beta hydrolase of unknown function (DUF915) HLLCKODE_00251 904306.HMPREF9192_1074 8.4e-227 792.7 Bacilli pts13C ko:K02761 ko00500,ko02060,map00500,map02060 M00275 R11170,R11172 RC00017,RC03206 ko00000,ko00001,ko00002,ko02000 4.A.3.2 Bacteria 1V5SI@1239,4HJTK@91061,COG1455@1,COG1455@2 NA|NA|NA G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane HLLCKODE_00252 1046629.Ssal_00789 3.7e-168 597.4 Bacilli bcrA ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TPBQ@1239,4HAGA@91061,COG1131@1,COG1131@2 NA|NA|NA V abc transporter atp-binding protein HLLCKODE_00253 904306.HMPREF9192_1072 1.8e-128 465.3 Bacilli ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1VMES@1239,2EGU7@1,33AKD@2,4HQPP@91061 NA|NA|NA S ABC-2 family transporter protein HLLCKODE_00254 546270.GEMHA0001_1118 1.3e-78 300.8 Bacilli Bacteria 1VC3P@1239,4HQVU@91061,COG1403@1,COG1403@2 NA|NA|NA V HNH nucleases HLLCKODE_00255 546270.GEMHA0001_1119 1.6e-132 480.3 Bacilli Bacteria 1VHTQ@1239,4HX8K@91061,COG3950@1,COG3950@2 NA|NA|NA S AAA domain, putative AbiEii toxin, Type IV TA system HLLCKODE_00256 1046629.Ssal_00786 1.5e-147 528.9 Bacilli Bacteria 1UYK9@1239,4IPWV@91061,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor HLLCKODE_00257 1046629.Ssal_00785 9.9e-126 456.1 Bacilli Bacteria 1TT2Z@1239,4HDGH@91061,COG0745@1,COG0745@2 NA|NA|NA T Xre family transcriptional regulator HLLCKODE_00258 1046629.Ssal_00784 1.2e-109 402.5 Bacilli drgA Bacteria 1UXYI@1239,4HBMN@91061,COG0778@1,COG0778@2 NA|NA|NA C nitroreductase HLLCKODE_00259 904306.HMPREF9192_1065 1e-101 376.3 Firmicutes yoaK Bacteria 1V9ME@1239,COG3619@1,COG3619@2 NA|NA|NA S Protein of unknown function (DUF1275) HLLCKODE_00260 1046629.Ssal_00782 9e-40 169.1 Bacteria ko:K06218 ko00000,ko02048 Bacteria COG2026@1,COG2026@2 NA|NA|NA DJ nuclease activity HLLCKODE_00261 1046629.Ssal_00781 1.1e-30 138.7 Bacilli XK27_10490 Bacteria 1VIWV@1239,2DQ9B@1,335EQ@2,4HQTB@91061 NA|NA|NA HLLCKODE_00262 1046629.Ssal_00780 1.2e-157 562.4 Bacilli yvgN Bacteria 1TPM1@1239,4HARE@91061,COG0656@1,COG0656@2 NA|NA|NA C reductase HLLCKODE_00263 1046629.Ssal_00779 7.1e-209 733.0 Bacilli Bacteria 1VBH7@1239,4IS2V@91061,COG0457@1,COG0457@2 NA|NA|NA S Tetratricopeptide repeat HLLCKODE_00264 435842.HMPREF0848_00966 0.0 2069.7 Bacilli lacL 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 Bacteria 1TPDC@1239,4HANW@91061,COG3250@1,COG3250@2 NA|NA|NA G -beta-galactosidase HLLCKODE_00265 1046629.Ssal_00776 0.0 1221.5 Bacilli lacS GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03292,ko:K11104,ko:K16209 ko00000,ko02000 2.A.2,2.A.2.1,2.A.2.2 Bacteria 1TRA5@1239,4HCDS@91061,COG2190@1,COG2190@2,COG2211@1,COG2211@2 NA|NA|NA G transporter HLLCKODE_00266 1046629.Ssal_00775 1.4e-200 705.3 Bacilli galM 5.1.3.3 ko:K01785 ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130 M00632 R01602,R10619 RC00563 ko00000,ko00001,ko00002,ko01000 Bacteria 1V5UK@1239,4HTRY@91061,COG2017@1,COG2017@2 NA|NA|NA G Catalyzes the interconversion of alpha and beta anomers of maltose HLLCKODE_00267 435842.HMPREF0848_00969 1.1e-194 685.6 Bacilli galE 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQ7N@1239,4H9U5@91061,COG1087@1,COG1087@2 NA|NA|NA M Belongs to the NAD(P)-dependent epimerase dehydratase family HLLCKODE_00268 1046629.Ssal_00773 9.8e-288 995.3 Bacilli galT 2.7.7.12 ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 M00362,M00554,M00632 R00955 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPBN@1239,4HAYJ@91061,COG4468@1,COG4468@2 NA|NA|NA G UDPglucose--hexose-1-phosphate uridylyltransferase HLLCKODE_00269 435842.HMPREF0848_00971 2.1e-221 774.6 Bacilli galK GO:0005975,GO:0005996,GO:0006012,GO:0008150,GO:0008152,GO:0019318,GO:0044238,GO:0044281,GO:0071704 2.7.1.6 ko:K00849 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00554,M00632 R01092 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1TPD0@1239,4HARP@91061,COG0153@1,COG0153@2 NA|NA|NA G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) HLLCKODE_00270 1046629.Ssal_00771 3.2e-181 641.0 Bacilli galR ko:K02529 ko00000,ko03000 Bacteria 1TPZJ@1239,4HC9Z@91061,COG1609@1,COG1609@2 NA|NA|NA K Transcriptional regulator HLLCKODE_00271 904306.HMPREF9192_1062 6e-307 1059.3 Bacilli dexB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.2.1.10,3.2.1.70 ko:K01182,ko:K01215 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00801,R01718,R01791,R06199 RC00028,RC00059,RC00077,RC00451 ko00000,ko00001,ko01000 GH13 Bacteria 1TP53@1239,4HA1G@91061,COG0366@1,COG0366@2 NA|NA|NA G COG0366 Glycosidases HLLCKODE_00272 1046629.Ssal_00769 7.9e-225 786.2 Bacilli vncS 2.7.13.3 ko:K10819,ko:K18986 ko02020,map02020 M00719 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1TQZD@1239,4HDFP@91061,COG0642@1,COG0642@2 NA|NA|NA T Histidine kinase HLLCKODE_00273 999425.HMPREF9186_00549 2e-115 421.8 Bacilli Bacteria 1TT7R@1239,4HG6F@91061,COG0745@1,COG0745@2 NA|NA|NA K Response regulator receiver domain protein HLLCKODE_00274 904306.HMPREF9192_1059 4.6e-239 833.6 Bacilli vex3 ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TPSE@1239,4HDMR@91061,COG0577@1,COG0577@2 NA|NA|NA V Efflux ABC transporter, permease protein HLLCKODE_00275 1046629.Ssal_00766 1e-108 399.4 Bacilli vex2 ko:K02003,ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TP5M@1239,4HBJW@91061,COG1136@1,COG1136@2 NA|NA|NA V abc transporter atp-binding protein HLLCKODE_00276 904306.HMPREF9192_1057 7.8e-177 626.7 Bacilli vex1 ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TT8B@1239,4HFDY@91061,COG0577@1,COG0577@2 NA|NA|NA V Efflux ABC transporter, permease protein HLLCKODE_00277 1046629.Ssal_00764 1.5e-283 981.5 Bacilli XK27_07020 Bacteria 1TQYE@1239,4HDNX@91061,COG4868@1,COG4868@2 NA|NA|NA S Belongs to the UPF0371 family HLLCKODE_00279 1046629.Ssal_00761 1.9e-195 688.3 Bacilli gldA 1.1.1.6 ko:K00005 ko00561,ko00640,ko01100,map00561,map00640,map01100 R01034,R10715,R10717 RC00029,RC00117,RC00670 ko00000,ko00001,ko01000 Bacteria 1TQFU@1239,4HC8K@91061,COG0371@1,COG0371@2 NA|NA|NA C glycerol dehydrogenase HLLCKODE_00280 435842.HMPREF0848_00978 3e-176 624.4 Bacilli XK27_10475 Bacteria 1TPT5@1239,4HAPJ@91061,COG0673@1,COG0673@2 NA|NA|NA S oxidoreductase HLLCKODE_00281 1046629.Ssal_00759 8.2e-58 229.6 Firmicutes dhaM GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0047324 2.7.1.121 ko:K05881 ko00561,map00561 R01012 RC00015,RC00017 ko00000,ko00001,ko01000,ko02000 Bacteria 1VF32@1239,COG3412@1,COG3412@2 NA|NA|NA S dihydroxyacetone kinase, phosphotransfer subunit HLLCKODE_00282 1046629.Ssal_00758 9e-96 356.3 Bacilli dhaL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0046872,GO:0047324,GO:0097159,GO:0097367,GO:1901265,GO:1901363 2.7.1.121 ko:K05879 ko00561,ko01100,map00561,map01100 R01012 RC00015,RC00017 ko00000,ko00001,ko01000 Bacteria 1V4FH@1239,4HGZY@91061,COG1461@1,COG1461@2 NA|NA|NA S Dihydroxyacetone kinase HLLCKODE_00283 1046629.Ssal_00757 4.5e-180 637.1 Bacilli dhaK GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019637,GO:0019751,GO:0033554,GO:0034308,GO:0042180,GO:0042182,GO:0042802,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0047324,GO:0050896,GO:0051716,GO:0061610,GO:0071704,GO:1901135,GO:1901575,GO:1901615 2.7.1.121,2.7.1.28,2.7.1.29,4.6.1.15 ko:K00863,ko:K05878,ko:K05879 ko00051,ko00561,ko00680,ko01100,ko01120,ko01200,ko04622,map00051,map00561,map00680,map01100,map01120,map01200,map04622 M00344 R01011,R01012,R01059 RC00002,RC00015,RC00017 ko00000,ko00001,ko00002,ko01000 iEcHS_1320.EcHS_A1304,iUMNK88_1353.UMNK88_1515,iYL1228.KPN_03495 Bacteria 1TP92@1239,4H9VS@91061,COG2376@1,COG2376@2 NA|NA|NA G Dihydroxyacetone kinase HLLCKODE_00284 1046629.Ssal_00756 2.8e-227 794.3 Firmicutes thrE Bacteria 1TSE8@1239,COG2966@1,COG2966@2,COG3610@1,COG3610@2 NA|NA|NA K Psort location CytoplasmicMembrane, score HLLCKODE_00285 1046629.Ssal_00755 0.0 1967.2 Firmicutes Bacteria 1V0PX@1239,COG5263@1,COG5263@2 NA|NA|NA M Putative cell wall binding repeat HLLCKODE_00286 927666.SOR_0713 2.4e-34 151.4 Bacilli Bacteria 1U54E@1239,2DKHV@1,309HT@2,4I1BW@91061 NA|NA|NA S Immunity protein 41 HLLCKODE_00287 1046629.Ssal_00750 0.0 1288.1 Bacilli pepO 3.4.24.71 ko:K01415,ko:K07386 ko00000,ko01000,ko01002,ko04147 Bacteria 1TQTA@1239,4HDSF@91061,COG3590@1,COG3590@2 NA|NA|NA O Peptidase family M13 HLLCKODE_00288 1069533.Sinf_1729 4.5e-07 60.8 Bacilli Bacteria 1VP2X@1239,2EGBF@1,33A3A@2,4HS3U@91061 NA|NA|NA S Enterocin A Immunity HLLCKODE_00289 1123307.KB904375_gene405 1.6e-15 89.7 Bacteria Bacteria COG5658@1,COG5658@2 NA|NA|NA S integral membrane protein HLLCKODE_00290 1046629.Ssal_00745 4.2e-43 180.3 Bacilli czrA Bacteria 1UKJV@1239,4ITJ6@91061,COG0640@1,COG0640@2 NA|NA|NA K helix_turn_helix, Arsenical Resistance Operon Repressor HLLCKODE_00291 1046629.Ssal_00744 1.3e-110 406.0 Bacteria yhfC Bacteria COG4377@1,COG4377@2 NA|NA|NA S Putative membrane peptidase family (DUF2324) HLLCKODE_00292 1046629.Ssal_00742 0.0 2702.5 Bacilli GO:0005575,GO:0005576 2.4.1.5 ko:K00689,ko:K20276 ko00500,ko02020,ko02024,map00500,map02020,map02024 R02120,R06066 RC00028 ko00000,ko00001,ko01000 GH13 Bacteria 1VQXK@1239,4HEIA@91061,COG0366@1,COG0366@2,COG5263@1,COG5263@2 NA|NA|NA M KxYKxGKxW signal domain protein HLLCKODE_00294 1046629.Ssal_00740 1.7e-258 898.7 Bacteria Bacteria COG5263@1,COG5263@2 NA|NA|NA S dextransucrase activity HLLCKODE_00295 1046629.Ssal_00738 0.0 2317.0 Bacilli GO:0005575,GO:0005576 2.4.1.5 ko:K00689,ko:K20276 ko00500,ko02020,ko02024,map00500,map02020,map02024 R02120,R06066 RC00028 ko00000,ko00001,ko01000 GH13 Bacteria 1VQXK@1239,4HEIA@91061,COG0366@1,COG0366@2,COG5263@1,COG5263@2 NA|NA|NA M KxYKxGKxW signal domain protein HLLCKODE_00296 1046629.Ssal_00736 0.0 1314.3 Bacteria Bacteria COG5263@1,COG5263@2 NA|NA|NA S dextransucrase activity HLLCKODE_00297 1046629.Ssal_00731 4e-99 367.5 Bacilli pdxT GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600 4.3.3.6 ko:K08681 ko00750,map00750 R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 iHN637.CLJU_RS19495 Bacteria 1V3I6@1239,4HFSZ@91061,COG0311@1,COG0311@2 NA|NA|NA H Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS HLLCKODE_00298 1046629.Ssal_00730 6.9e-156 556.6 Bacilli pdxS GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0040007,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 4.3.3.6 ko:K06215 ko00750,map00750 R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 Bacteria 1TPSZ@1239,4H9RA@91061,COG0214@1,COG0214@2 NA|NA|NA H Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively HLLCKODE_00299 1046629.Ssal_00728 1.9e-299 1034.6 Bacteria Bacteria COG5263@1,COG5263@2 NA|NA|NA S dextransucrase activity HLLCKODE_00300 1046629.Ssal_00725 4.5e-186 658.7 Bacteria Bacteria COG5263@1,COG5263@2 NA|NA|NA S dextransucrase activity HLLCKODE_00302 1123309.AQYB01000022_gene40 1.9e-07 60.1 Bacilli Bacteria 1VNP3@1239,2ED1A@1,336Y8@2,4HRCX@91061 NA|NA|NA HLLCKODE_00307 1046629.Ssal_02107 0.0 2808.5 Bacilli polC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.7.7 ko:K02342,ko:K03763 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 1TPAG@1239,4H9RF@91061,COG2176@1,COG2176@2 NA|NA|NA L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity HLLCKODE_00308 1046629.Ssal_02106 4.9e-232 810.1 Bacilli pepS ko:K19689 ko00000,ko01000,ko01002 Bacteria 1TP65@1239,4H9W8@91061,COG2309@1,COG2309@2 NA|NA|NA E COG2309 Leucyl aminopeptidase (aminopeptidase T) HLLCKODE_00309 904306.HMPREF9192_0535 1.2e-35 155.2 Bacteria XK27_02060 Bacteria COG2261@1,COG2261@2 NA|NA|NA S Transglycosylase associated protein HLLCKODE_00310 1046629.Ssal_02104 3.9e-72 277.3 Bacilli badR ko:K15973 ko00000,ko03000 Bacteria 1VB3Q@1239,4HP7J@91061,COG1846@1,COG1846@2 NA|NA|NA K Transcriptional regulator, marr family HLLCKODE_00311 904306.HMPREF9192_0533 1.1e-92 345.9 Firmicutes ko:K19784 ko00000 Bacteria 1VAI8@1239,COG0431@1,COG0431@2 NA|NA|NA S reductase HLLCKODE_00313 1046629.Ssal_02102 1.8e-284 984.6 Bacilli ahpF ko:K03387 ko00000,ko01000 Bacteria 1TPYN@1239,4H9W1@91061,COG3634@1,COG3634@2 NA|NA|NA O alkyl hydroperoxide reductase HLLCKODE_00314 1046629.Ssal_02101 4.2e-106 390.6 Bacilli ahpC GO:0003674,GO:0003824,GO:0004601,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009321,GO:0009605,GO:0009636,GO:0009970,GO:0009987,GO:0009991,GO:0010033,GO:0016209,GO:0016491,GO:0016667,GO:0016671,GO:0016684,GO:0019725,GO:0030003,GO:0031667,GO:0031668,GO:0031669,GO:0032843,GO:0032991,GO:0033194,GO:0033195,GO:0033212,GO:0033214,GO:0033554,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071496,GO:0097237,GO:0098754,GO:0098771,GO:0098869,GO:1901700,GO:1902494,GO:1990204,GO:1990748 1.11.1.15 ko:K03386 ko04214,map04214 ko00000,ko00001,ko01000,ko04147 Bacteria 1TQU7@1239,4HA2M@91061,COG0450@1,COG0450@2 NA|NA|NA O alkyl hydroperoxide reductase HLLCKODE_00315 1046629.Ssal_02100 7.4e-138 496.5 Bacilli rpsB GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02967 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1TPNA@1239,4H9N5@91061,COG0052@1,COG0052@2 NA|NA|NA J Belongs to the universal ribosomal protein uS2 family HLLCKODE_00316 1046629.Ssal_02098 1e-182 646.0 Bacilli tsf GO:0001871,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005085,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0019538,GO:0019899,GO:0030246,GO:0030247,GO:0034641,GO:0034645,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051020,GO:0065007,GO:0065009,GO:0071704,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065 ko:K02357 ko00000,ko03012,ko03029 Bacteria 1TPFJ@1239,4HBDV@91061,COG0264@1,COG0264@2 NA|NA|NA J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome HLLCKODE_00317 1046629.Ssal_02096 1.6e-82 312.0 Bacilli Bacteria 1V3UW@1239,4HPN6@91061,COG2426@1,COG2426@2 NA|NA|NA S Putative small multi-drug export protein HLLCKODE_00318 1046629.Ssal_02095 2e-74 285.0 Bacilli ctsR GO:0006950,GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0046688,GO:0050896,GO:0097501,GO:1990169,GO:1990170 ko:K03708 ko00000,ko03000 Bacteria 1VAXT@1239,4HIFT@91061,COG4463@1,COG4463@2 NA|NA|NA K Belongs to the CtsR family HLLCKODE_00319 904306.HMPREF9192_0525 0.0 1539.6 Bacilli clpC GO:0006950,GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0046688,GO:0050896,GO:0097501,GO:1990169,GO:1990170 ko:K03696 ko01100,map01100 ko00000,ko03110 Bacteria 1TPMU@1239,4HACY@91061,COG0542@1,COG0542@2 NA|NA|NA O Belongs to the ClpA ClpB family HLLCKODE_00320 1046629.Ssal_02093 5.1e-229 800.0 Bacilli dacA GO:0003674,GO:0003824,GO:0004175,GO:0004180,GO:0004185,GO:0005575,GO:0005618,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0009002,GO:0016787,GO:0017171,GO:0019538,GO:0030312,GO:0043170,GO:0044238,GO:0044464,GO:0070008,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 3.4.16.4 ko:K01286,ko:K07258 ko00550,ko01100,map00550,map01100 ko00000,ko00001,ko01000,ko01002,ko01011 Bacteria 1TQN0@1239,4HBD4@91061,COG1686@1,COG1686@2 NA|NA|NA M Belongs to the peptidase S11 family HLLCKODE_00321 1046629.Ssal_02092 5.8e-225 786.6 Bacilli dacA GO:0003674,GO:0003824,GO:0004175,GO:0004180,GO:0004185,GO:0005575,GO:0005618,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0009002,GO:0016787,GO:0017171,GO:0019538,GO:0030312,GO:0043170,GO:0044238,GO:0044464,GO:0070008,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 3.4.16.4 ko:K01286,ko:K07258 ko00550,ko01100,map00550,map01100 ko00000,ko00001,ko01000,ko01002,ko01011 Bacteria 1TQN0@1239,4HBD4@91061,COG1686@1,COG1686@2 NA|NA|NA M Belongs to the peptidase S11 family HLLCKODE_00322 1046629.Ssal_02091 0.0 1364.7 Bacilli pnp GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 Bacteria 1TQDW@1239,4H9Z3@91061,COG1185@1,COG1185@2 NA|NA|NA J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction HLLCKODE_00323 1046629.Ssal_02090 3.6e-140 504.2 Bacilli Bacteria 1VY65@1239,2F67I@1,33YRI@2,4HXHY@91061 NA|NA|NA S SseB protein N-terminal domain HLLCKODE_00324 1046629.Ssal_02089 2.5e-112 411.4 Bacilli cysE 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 Bacteria 1TR42@1239,4HAKS@91061,COG1045@1,COG1045@2 NA|NA|NA E serine acetyltransferase HLLCKODE_00326 1046629.Ssal_02087 8.1e-257 892.5 Bacilli cysS GO:0000166,GO:0001871,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030246,GO:0030247,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065 6.1.1.16,6.3.1.13 ko:K01883,ko:K15526 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iECUMN_1333.ECUMN_0566,iJN746.PP_2905 Bacteria 1TP9D@1239,4HA6D@91061,COG0215@1,COG0215@2 NA|NA|NA J Belongs to the class-I aminoacyl-tRNA synthetase family HLLCKODE_00327 1046629.Ssal_02085 2.7e-67 261.2 Bacilli mrnC GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 ko:K11145 ko00000,ko01000,ko03009 Bacteria 1VA5V@1239,4HIM3@91061,COG1939@1,COG1939@2 NA|NA|NA J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) HLLCKODE_00329 1046629.Ssal_02082 9.7e-135 486.1 Bacilli trmH GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 ko:K03218,ko:K03437,ko:K12952 ko00000,ko01000,ko03009,ko03016 3.A.3.23 Bacteria 1TP9G@1239,4HBBI@91061,COG0566@1,COG0566@2 NA|NA|NA J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family HLLCKODE_00330 1046629.Ssal_02081 2.7e-91 341.3 Bacilli yacP ko:K06962 ko00000 Bacteria 1V9XR@1239,4HFW4@91061,COG3688@1,COG3688@2 NA|NA|NA S RNA-binding protein containing a PIN domain HLLCKODE_00331 1046629.Ssal_02080 4.1e-153 547.4 Bacilli degV Bacteria 1TQDI@1239,4HAYQ@91061,COG1307@1,COG1307@2 NA|NA|NA S DegV family HLLCKODE_00333 1046629.Ssal_02078 5.1e-22 109.8 Bacilli ko:K07729 ko00000,ko03000 Bacteria 1VERT@1239,4HNID@91061,COG1476@1,COG1476@2 NA|NA|NA K Transcriptional HLLCKODE_00334 1046629.Ssal_02077 2e-79 301.6 Bacilli rplM GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0070180,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02871 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V3HX@1239,4HG0I@91061,COG0102@1,COG0102@2 NA|NA|NA J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly HLLCKODE_00335 1046629.Ssal_02076 7.3e-65 253.1 Bacilli rpsI GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02996 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V3MQ@1239,4HH3B@91061,COG0103@1,COG0103@2 NA|NA|NA J Belongs to the universal ribosomal protein uS9 family HLLCKODE_00336 388919.SSA_2297 2e-18 99.4 Streptococcus sanguinis Bacteria 1UA2V@1239,1WR6Y@1305,29RI7@1,30CM6@2,4IKCA@91061 NA|NA|NA HLLCKODE_00337 1046629.Ssal_02065 1e-28 132.1 Bacilli ko:K07729 ko00000,ko03000 Bacteria 1VEGF@1239,4IPKE@91061,COG1476@1,COG1476@2 NA|NA|NA K Helix-turn-helix domain HLLCKODE_00339 435842.HMPREF0848_01916 2e-149 535.0 Bacilli srtB 3.4.22.70 ko:K08600 ko00000,ko01000,ko01002,ko01011 Bacteria 1V2FT@1239,4IQ4U@91061,COG4509@1,COG4509@2 NA|NA|NA S Sortase family HLLCKODE_00340 1046629.Ssal_02062 1.5e-233 815.1 Bacilli capA ko:K07282 ko00000 Bacteria 1UZW4@1239,4HBC3@91061,COG2843@1,COG2843@2 NA|NA|NA M Bacterial capsule synthesis protein HLLCKODE_00341 1046629.Ssal_02061 1e-38 165.6 Bacilli gcvR ko:K07166 ko00000 Bacteria 1VENW@1239,4HNJ4@91061,COG3830@1,COG3830@2 NA|NA|NA T UPF0237 protein HLLCKODE_00342 904306.HMPREF9192_0489 2.3e-243 847.8 Bacilli XK27_08635 ko:K09157 ko00000 Bacteria 1TQG8@1239,4HBTU@91061,COG2848@1,COG2848@2 NA|NA|NA S UPF0210 protein HLLCKODE_00343 904306.HMPREF9192_0488 3.6e-131 474.2 Bacilli ais Bacteria 1VDCB@1239,4HJ9X@91061,COG0406@1,COG0406@2 NA|NA|NA G Phosphoglycerate mutase HLLCKODE_00344 1046629.Ssal_02058 3.8e-137 494.2 Bacilli vanY 3.4.17.14 ko:K07260 ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020 M00651 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504 Bacteria 1V1F7@1239,4HBR1@91061,COG1876@1,COG1876@2 NA|NA|NA M D-alanyl-D-alanine carboxypeptidase HLLCKODE_00345 1046629.Ssal_02057 4.4e-98 364.0 Bacilli acmA 3.2.1.17,3.4.17.14,3.5.1.28 ko:K01185,ko:K01448,ko:K02395,ko:K07260 ko00550,ko01100,ko01502,ko01503,ko02020,map00550,map01100,map01502,map01503,map02020 M00651,M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504,ko02035,ko03036 Bacteria 1V7JY@1239,4HIY4@91061,COG1705@1,COG1705@2 NA|NA|NA NU Muramidase (Flagellum-specific) HLLCKODE_00346 904306.HMPREF9192_0485 3.7e-185 654.1 Bacilli hrcA GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K03705 ko00000,ko03000 Bacteria 1TQP7@1239,4HAX5@91061,COG1420@1,COG1420@2 NA|NA|NA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons HLLCKODE_00347 1046629.Ssal_02055 8.2e-64 250.0 Bacilli grpE GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009408,GO:0009605,GO:0009628,GO:0009986,GO:0009987,GO:0009991,GO:0016043,GO:0017076,GO:0019904,GO:0022607,GO:0030234,GO:0030246,GO:0030247,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0042802,GO:0042803,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065003,GO:0065007,GO:0065009,GO:0071496,GO:0071840,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065 ko:K03687 ko00000,ko03029,ko03110 Bacteria 1V6G2@1239,4HIRK@91061,COG0576@1,COG0576@2 NA|NA|NA O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HLLCKODE_00348 435842.HMPREF0848_01925 2.3e-302 1044.3 Bacilli dnaK GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0009986,GO:0030246,GO:0030247,GO:0044464,GO:0051704,GO:0098630,GO:0098743,GO:2001065 ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 Bacteria 1TP1J@1239,4HA9S@91061,COG0443@1,COG0443@2 NA|NA|NA O Heat shock 70 kDa protein HLLCKODE_00349 904306.HMPREF9192_0482 9.3e-193 679.5 Bacilli dnaJ ko:K03686 ko00000,ko03029,ko03110 Bacteria 1TP00@1239,4H9KA@91061,COG0484@1,COG0484@2 NA|NA|NA O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins HLLCKODE_00350 1046629.Ssal_02051 7.7e-140 503.1 Bacilli truA GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 ko:K06173 ko00000,ko01000,ko03016 Bacteria 1TQUY@1239,4HCFI@91061,COG0101@1,COG0101@2 NA|NA|NA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs HLLCKODE_00351 904306.HMPREF9192_0479 5.8e-135 486.9 Bacilli thiD 2.7.1.35,2.7.1.49,2.7.4.7 ko:K00868,ko:K00941 ko00730,ko00750,ko01100,map00730,map00750,map01100 M00127 R00174,R01909,R02493,R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQ4A@1239,4H9PP@91061,COG0351@1,COG0351@2 NA|NA|NA H phosphomethylpyrimidine kinase HLLCKODE_00352 1046629.Ssal_02049 6.3e-79 300.1 Bacilli hmpT GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 1VBBN@1239,4HNM0@91061,COG4720@1,COG4720@2 NA|NA|NA S cog cog4720 HLLCKODE_00353 1046629.Ssal_01235 1.1e-11 75.1 Bacilli mnaA 5.1.3.14 ko:K01791 ko00520,ko01100,ko05111,map00520,map01100,map05111 M00362 R00420 RC00290 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria 1TQZT@1239,4HBI3@91061,COG0381@1,COG0381@2 NA|NA|NA G Belongs to the UDP-N-acetylglucosamine 2-epimerase family HLLCKODE_00354 435842.HMPREF0848_01223 6.6e-166 590.1 Bacilli Bacteria 1UQA9@1239,4HBNE@91061,COG2199@1,COG2199@2 NA|NA|NA T Diguanylate cyclase HLLCKODE_00355 435842.HMPREF0848_01224 9.9e-149 533.1 Bacilli 2.4.1.83 ko:K00721,ko:K20534 ko00510,ko01100,map00510,map01100 R01009 RC00005 ko00000,ko00001,ko01000,ko01003,ko01005,ko02000 4.D.2.1.9 GT2 Bacteria 1TQ8C@1239,4HDD4@91061,COG0463@1,COG0463@2,COG2246@1,COG2246@2 NA|NA|NA M COG0463, glycosyltransferases involved in cell wall biogenesis HLLCKODE_00356 435842.HMPREF0848_01225 0.0 1496.9 Bacilli bcsA 2.4.1.12 ko:K00694 ko00500,ko01100,ko02026,map00500,map01100,map02026 R02889 RC00005 ko00000,ko00001,ko01000,ko01003,ko02000 4.D.3.1.2,4.D.3.1.5,4.D.3.1.6 GT2 Bacteria 1TSD3@1239,4HD23@91061,COG1215@1,COG1215@2 NA|NA|NA M COG1215 Glycosyltransferases, probably involved in cell wall biogenesis HLLCKODE_00357 435842.HMPREF0848_01226 0.0 1116.3 Bacilli Bacteria 1TPQ9@1239,28KEZ@1,2ZA17@2,4HFER@91061 NA|NA|NA HLLCKODE_00358 873447.SPB_1682 3.1e-24 117.1 Bacilli uvrX 2.7.7.7 ko:K02346,ko:K03502,ko:K14161 ko00000,ko01000,ko03400 Bacteria 1TP42@1239,4HA1P@91061,COG0389@1,COG0389@2 NA|NA|NA L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII HLLCKODE_00359 435842.HMPREF0848_01227 2.7e-79 301.2 Bacilli Bacteria 1VUJF@1239,2F0Z4@1,33U0S@2,4I1M0@91061 NA|NA|NA HLLCKODE_00360 435842.HMPREF0848_01228 5.4e-124 450.3 Bacilli Bacteria 1TQWX@1239,4HY19@91061,COG2932@1,COG2932@2 NA|NA|NA K Peptidase S24-like protein HLLCKODE_00361 888833.HMPREF9421_0310 1.9e-94 352.1 Bacilli Bacteria 1VPKW@1239,4HZKQ@91061,COG2856@1,COG2856@2 NA|NA|NA E IrrE N-terminal-like domain HLLCKODE_00362 888746.HMPREF9180_1568 6.2e-79 300.8 Bacilli Bacteria 1VV0W@1239,2EDPB@1,337J0@2,4HVVE@91061 NA|NA|NA HLLCKODE_00363 562983.HMPREF0433_00672 4.5e-78 298.1 Bacilli Bacteria 1VWCK@1239,2F5IH@1,33Y3W@2,4HW3I@91061 NA|NA|NA HLLCKODE_00364 563038.HMPREF0851_01447 2e-46 192.2 Bacilli Bacteria 1W3A8@1239,2DEIC@1,2ZN3X@2,4HZMP@91061 NA|NA|NA HLLCKODE_00365 563038.HMPREF0851_01448 8.8e-47 193.4 Bacilli Bacteria 1W3A8@1239,2DEIC@1,2ZN3X@2,4HZMP@91061 NA|NA|NA HLLCKODE_00366 1046629.Ssal_00447 3.3e-30 138.3 Bacilli yaaK ko:K09747 ko00000 Bacteria 1VA1S@1239,4HKH3@91061,COG0718@1,COG0718@2 NA|NA|NA S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection HLLCKODE_00368 1046629.Ssal_00444 1.9e-124 451.8 Bacilli ko:K02003,ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TQC9@1239,4HB8D@91061,COG1136@1,COG1136@2 NA|NA|NA V abc transporter atp-binding protein HLLCKODE_00369 1046629.Ssal_00443 0.0 1625.5 Bacilli ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TPHU@1239,4HA2C@91061,COG0577@1,COG0577@2 NA|NA|NA V ABC transporter (Permease HLLCKODE_00370 435842.HMPREF0848_01235 3.9e-128 464.2 Bacilli Bacteria 1UZ0H@1239,4HGGU@91061,COG0789@1,COG0789@2 NA|NA|NA K transcriptional regulator, MerR family HLLCKODE_00371 1046629.Ssal_00440 4.9e-105 387.1 Bacilli dnaQ 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 1V8EQ@1239,4HJYT@91061,COG0847@1,COG0847@2 NA|NA|NA L DNA polymerase III HLLCKODE_00372 1046629.Ssal_00439 9.1e-42 176.8 Bacilli WQ51_02910 Bacteria 1VNC1@1239,2EHT6@1,33BIW@2,4HRJ5@91061 NA|NA|NA S Protein of unknown function, DUF536 HLLCKODE_00373 904306.HMPREF9192_0775 1.3e-63 248.8 Bacilli XK27_02560 ko:K02612 ko00360,ko01120,map00360,map01120 R09838 RC02690 ko00000,ko00001 Bacteria 1VX9Z@1239,4HXCM@91061,COG2151@1,COG2151@2 NA|NA|NA S cog cog2151 HLLCKODE_00374 1046629.Ssal_00436 0.0 1132.9 Bacilli ilvD GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP1R@1239,4H9ZG@91061,COG0129@1,COG0129@2 NA|NA|NA E Belongs to the IlvD Edd family HLLCKODE_00375 1046629.Ssal_00435 1.1e-211 742.3 Bacilli ytfP ko:K07007 ko00000 Bacteria 1TQ6E@1239,4HAAT@91061,COG2081@1,COG2081@2 NA|NA|NA S Flavoprotein HLLCKODE_00377 1046629.Ssal_00434 2e-120 438.3 Bacilli trmB GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.297,2.1.1.33 ko:K02493,ko:K03439 R10806 RC00003,RC03279 ko00000,ko01000,ko03012,ko03016 Bacteria 1TQCA@1239,4HC08@91061,COG0220@1,COG0220@2 NA|NA|NA J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA HLLCKODE_00378 1046629.Ssal_00433 7.1e-152 543.1 Bacilli ytmP 2.7.1.89 ko:K07251 ko00730,ko01100,map00730,map01100 R02134 RC00002,RC00017 ko00000,ko00001,ko01000 Bacteria 1UMFY@1239,4HBF9@91061,COG0510@1,COG0510@2 NA|NA|NA M Phosphotransferase HLLCKODE_00379 1046629.Ssal_00432 1e-174 619.4 Firmicutes ecsB ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1V9K7@1239,COG4473@1,COG4473@2 NA|NA|NA U Bacterial ABC transporter protein EcsB HLLCKODE_00380 1046629.Ssal_00431 2.6e-132 478.0 Bacilli ecsA ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TQIH@1239,4HA2B@91061,COG1131@1,COG1131@2 NA|NA|NA V abc transporter atp-binding protein HLLCKODE_00381 435842.HMPREF0848_01246 8.6e-72 276.2 Bacilli hit ko:K02503 ko00000,ko04147 Bacteria 1V9ZJ@1239,4HIG2@91061,COG0537@1,COG0537@2 NA|NA|NA FG Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases HLLCKODE_00385 1046629.Ssal_00427 1.6e-103 382.1 Firmicutes Bacteria 1V92M@1239,2AIHW@1,318ZT@2 NA|NA|NA HLLCKODE_00387 1046629.Ssal_00425 0.0 1343.9 Bacilli clpL ko:K04086 ko00000,ko03110 Bacteria 1TRHP@1239,4HAHZ@91061,COG0542@1,COG0542@2 NA|NA|NA O ATP-dependent Clp protease ATP-binding subunit HLLCKODE_00388 1046629.Ssal_00423 1e-43 182.2 Bacilli yoeB ko:K19158 ko00000,ko01000,ko02048 Bacteria 1VEN0@1239,4HRVW@91061,COG4115@1,COG4115@2 NA|NA|NA S Addiction module toxin, Txe YoeB family HLLCKODE_00389 1046629.Ssal_00422 7.6e-39 166.0 Bacilli yefM 2.3.1.15 ko:K08591,ko:K19158,ko:K19159 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004,ko02048 Bacteria 1VM12@1239,4HRMU@91061,COG2161@1,COG2161@2 NA|NA|NA D Antitoxin component of a toxin-antitoxin (TA) module HLLCKODE_00390 435842.HMPREF0848_01254 1.8e-198 698.4 Bacilli ylbM Bacteria 1TPP2@1239,4HAZJ@91061,COG1323@1,COG1323@2 NA|NA|NA S Belongs to the UPF0348 family HLLCKODE_00391 435842.HMPREF0848_01255 1.3e-139 502.3 Bacilli yqeM Bacteria 1V24K@1239,4HDFY@91061,COG0500@1,COG2226@2 NA|NA|NA Q Methyltransferase domain protein HLLCKODE_00392 904306.HMPREF9192_0760 7.7e-58 229.6 Bacilli rsfS GO:0003674,GO:0005488,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113 ko:K09710 ko00000,ko03009 Bacteria 1VA2Z@1239,4HKEJ@91061,COG0799@1,COG0799@2 NA|NA|NA J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation HLLCKODE_00393 435842.HMPREF0848_01257 3e-87 327.8 Bacilli entB 3.5.1.19 ko:K08281 ko00760,ko01100,map00760,map01100 R01268 RC00100 ko00000,ko00001,ko01000 Bacteria 1VF7P@1239,4HQSB@91061,COG1335@1,COG1335@2 NA|NA|NA Q Isochorismatase family HLLCKODE_00394 1046629.Ssal_00418 3.2e-104 384.4 Bacilli nadD 2.7.6.3,2.7.7.18 ko:K00950,ko:K00969,ko:K06950 ko00760,ko00790,ko01100,map00760,map00790,map01100 M00115,M00126,M00841 R00137,R03005,R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 1V6Y1@1239,4HHRY@91061,COG1713@1,COG1713@2 NA|NA|NA H HD superfamily hydrolase involved in NAD metabolism HLLCKODE_00395 1046629.Ssal_00417 2.3e-116 424.9 Bacilli nadD GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18,3.6.1.55 ko:K00969,ko:K03574 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 Bacteria 1V3SK@1239,4HGXK@91061,COG1057@1,COG1057@2 NA|NA|NA H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) HLLCKODE_00396 1046629.Ssal_00416 7.7e-49 199.5 Bacilli yhbY GO:0000027,GO:0000028,GO:0000966,GO:0000967,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0034470,GO:0034471,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0042274,GO:0043021,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1990275 ko:K07574 ko00000,ko03009 Bacteria 1VEGM@1239,4HKC7@91061,COG1534@1,COG1534@2 NA|NA|NA J RNA-binding protein HLLCKODE_00397 1046629.Ssal_00415 1.6e-213 748.4 Bacilli yqeH GO:0003674,GO:0003824,GO:0003924,GO:0006275,GO:0008150,GO:0008156,GO:0009889,GO:0009890,GO:0009892,GO:0010556,GO:0010558,GO:0010605,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019219,GO:0019222,GO:0022613,GO:0030174,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0042254,GO:0044085,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0060255,GO:0065007,GO:0071840,GO:0080090,GO:0090329,GO:2000104,GO:2000112,GO:2000113 ko:K06948 ko00000,ko03009 Bacteria 1TPM2@1239,4HAAF@91061,COG1161@1,COG1161@2 NA|NA|NA S in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis HLLCKODE_00398 904306.HMPREF9192_0754 5.1e-98 363.6 Bacilli yqeG ko:K07015 ko00000 Bacteria 1V6KM@1239,4HGAV@91061,COG2179@1,COG2179@2 NA|NA|NA S hydrolase of the HAD superfamily HLLCKODE_00399 904306.HMPREF9192_0753 2.4e-151 541.6 Bacilli yicL Bacteria 1TR6G@1239,4HAMD@91061,COG0697@1,COG0697@2 NA|NA|NA EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily HLLCKODE_00400 1114965.Spaf_1654 1.5e-189 668.7 Bacilli bdhA GO:0000721,GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0055114 1.1.1.303,1.1.1.4 ko:K00004 ko00650,map00650 R02855,R02946,R10504 RC00205,RC00525 ko00000,ko00001,ko01000 iYO844.BSU06240 Bacteria 1TPWP@1239,4HABC@91061,COG1063@1,COG1063@2 NA|NA|NA E Dehydrogenase HLLCKODE_00401 435842.HMPREF0848_01264 6.9e-60 236.5 Bacilli Bacteria 1VBNR@1239,2B9ZC@1,323D0@2,4HNA3@91061 NA|NA|NA HLLCKODE_00403 1046629.Ssal_01709 1.4e-206 725.3 Bacilli 3.4.17.14,3.5.1.28 ko:K01448,ko:K02395,ko:K07260 ko00550,ko01100,ko01502,ko01503,ko02020,map00550,map01100,map01502,map01503,map02020 M00651,M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504,ko02035,ko03036 Bacteria 1W25V@1239,4HGXW@91061,COG0860@1,COG0860@2,COG1705@1,COG1705@2 NA|NA|NA M GBS Bsp-like repeat HLLCKODE_00404 176090.SSIN_1294 1.6e-25 121.3 Firmicutes Bacteria 1VPN1@1239,2ETKC@1,33M40@2 NA|NA|NA HLLCKODE_00405 1314.HKU360_00869 1.4e-100 372.5 Bacilli Bacteria 1TQ0D@1239,4HDA9@91061,COG0745@1,COG0745@2 NA|NA|NA KT Transcriptional regulatory protein, C terminal HLLCKODE_00406 1314.HKU360_00870 2.4e-167 595.1 Bacilli 2.7.13.3 ko:K10681,ko:K20487 ko02020,ko02024,map02020,map02024 M00468,M00816 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1VXY5@1239,4IPJR@91061,COG0642@1,COG0642@2 NA|NA|NA T His Kinase A (phosphoacceptor) domain HLLCKODE_00407 1314.HKU360_00875 9.4e-116 422.9 Bacilli mutF ko:K01990,ko:K20490 ko02010,ko02020,ko02024,map02010,map02020,map02024 M00254,M00817 ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.124.1,3.A.1.124.2,3.A.1.124.6 Bacteria 1TP4J@1239,4HG8J@91061,COG1131@1,COG1131@2 NA|NA|NA V AAA domain, putative AbiEii toxin, Type IV TA system HLLCKODE_00408 1314.HKU360_00876 2.4e-96 358.6 Bacilli spaE ko:K01992,ko:K20491,ko:K20492 ko02010,ko02020,ko02024,map02010,map02020,map02024 M00254,M00817 ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.124.1,3.A.1.124.2,3.A.1.124.6 Bacteria 1VFUH@1239,4HPRY@91061,COG4200@1,COG4200@2 NA|NA|NA S ABC-2 family transporter protein HLLCKODE_00409 1314.HKU360_00877 8.1e-70 270.4 Bacilli spaG ko:K20491,ko:K20492 ko02010,ko02020,ko02024,map02010,map02020,map02024 M00817 ko00000,ko00001,ko00002,ko02000 3.A.1.124.1,3.A.1.124.2,3.A.1.124.6 Bacteria 1VF96@1239,4HNVV@91061,COG4200@1,COG4200@2 NA|NA|NA S ABC-2 family transporter protein HLLCKODE_00411 388919.SSA_0160 4.2e-30 138.7 Streptococcus sanguinis Bacteria 1UACI@1239,1WS59@1305,2AR8X@1,31GIS@2,4IKQS@91061 NA|NA|NA HLLCKODE_00412 388919.SSA_0161 5e-114 418.7 Streptococcus sanguinis Bacteria 1TS2J@1239,1WS2P@1305,4HYWU@91061,COG3451@1,COG3451@2 NA|NA|NA U AAA-like domain HLLCKODE_00414 388919.SSA_0162 8e-14 84.3 Streptococcus sanguinis Bacteria 1UAC8@1239,1WS4T@1305,29RQ5@1,30CTJ@2,4IKQE@91061 NA|NA|NA HLLCKODE_00416 759913.SDSE_1687 9.1e-42 178.7 Streptococcus dysgalactiae group xisC GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009399,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0071941,GO:0090304,GO:0090305,GO:1901360 Bacteria 1M9Z5@119603,1TXDJ@1239,4I6BK@91061,COG0582@1,COG0582@2 NA|NA|NA L viral genome integration into host DNA HLLCKODE_00418 879308.HMPREF9130_0819 8.8e-51 207.2 Firmicutes Bacteria 1VXI1@1239,2DN8K@1,32W3T@2 NA|NA|NA HLLCKODE_00419 1316408.HSISM1_1338 0.0 1568.1 Bacilli Bacteria 1TRZH@1239,4HE9W@91061,COG1002@1,COG1002@2 NA|NA|NA V Type II restriction enzyme, methylase subunits HLLCKODE_00422 1140001.I571_02850 2.8e-95 356.7 Enterococcaceae traI 5.99.1.2 ko:K03169 ko00000,ko01000,ko03032 Bacteria 1TPJD@1239,4B026@81852,4HAZV@91061,COG0550@1,COG0550@2 NA|NA|NA L DNA topoisomerase HLLCKODE_00427 1214217.ALNF01000060_gene2203 3.6e-15 89.7 Bacteria dnaX 2.4.99.16,2.7.7.7 ko:K02343,ko:K02519,ko:K07114,ko:K16147 ko00230,ko00240,ko00500,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map00500,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378,R09994 RC02795 ko00000,ko00001,ko00002,ko01000,ko02000,ko03012,ko03029,ko03032,ko03400 1.A.13.2.2,1.A.13.2.3 GH13 Bacteria COG3115@1,COG3115@2 NA|NA|NA D cell septum assembly HLLCKODE_00428 1069533.Sinf_1806 7.6e-131 474.9 Bacteria Bacteria COG3087@1,COG3087@2 NA|NA|NA D Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides HLLCKODE_00429 706437.HMPREF0813_01505 5.5e-33 147.9 Streptococcus anginosus group Bacteria 1TVVB@1239,29H4I@1,30423@2,42E7R@671232,4I4DM@91061 NA|NA|NA HLLCKODE_00430 862970.SAIN_0151 2.3e-19 102.4 Streptococcus anginosus group Bacteria 1TVY9@1239,29H5Y@1,3043H@2,42EEJ@671232,4I4K4@91061 NA|NA|NA HLLCKODE_00432 264199.stu1386 5.7e-113 414.5 Bacilli Bacteria 1VBXK@1239,2CWIF@1,32SZQ@2,4HWJ5@91061 NA|NA|NA HLLCKODE_00433 264199.stu1385 4.4e-269 933.3 Bacilli uvrX 2.7.7.7 ko:K02346,ko:K03502,ko:K14161 ko00000,ko01000,ko03400 Bacteria 1TP42@1239,4HA1P@91061,COG0389@1,COG0389@2 NA|NA|NA L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII HLLCKODE_00434 322159.STER_1338 6.1e-58 229.9 Bacilli Bacteria 1VFMU@1239,2E59Z@1,33028@2,4HQG9@91061 NA|NA|NA HLLCKODE_00437 1282665.H353_08829 1.7e-16 93.6 Firmicutes Bacteria 1VQQ6@1239,COG1396@1,COG1396@2 NA|NA|NA K Helix-turn-helix XRE-family like proteins HLLCKODE_00438 1198676.SMUGS5_04550 3.7e-103 381.7 Bacilli xerS GO:0000150,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009987,GO:0015074,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140097,GO:1901360 Bacteria 1URNQ@1239,4HEPI@91061,COG4974@1,COG4974@2 NA|NA|NA D Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division HLLCKODE_00439 1095738.HMPREF1047_1139 5.1e-65 256.1 Streptococcus oralis Bacteria 1UN93@1239,1WQ05@1303,29YAF@1,30K4J@2,4IU86@91061 NA|NA|NA HLLCKODE_00442 388919.SSA_0168 2.2e-42 180.3 Streptococcus sanguinis Bacteria 1UAAQ@1239,1WS1U@1305,29RP8@1,30CSJ@2,4IKNH@91061 NA|NA|NA HLLCKODE_00443 1114965.Spaf_0019 1.3e-39 168.7 Bacilli Bacteria 1TQ5G@1239,4IPIE@91061,COG3547@1,COG3547@2 NA|NA|NA L Transposase IS116 IS110 IS902 HLLCKODE_00444 435842.HMPREF0848_01930 3.9e-66 257.3 Bacilli spxA_2 1.20.4.1 ko:K00537,ko:K16509 ko00000,ko01000 Bacteria 1VYBB@1239,4HWYC@91061,COG1393@1,COG1393@2 NA|NA|NA P Belongs to the ArsC family HLLCKODE_00445 1046629.Ssal_00984 2.9e-37 160.6 Bacilli ko:K07491 ko00000 Bacteria 1TSQ0@1239,4HDZ0@91061,COG1943@1,COG1943@2 NA|NA|NA L COG1943 Transposase and inactivated derivatives HLLCKODE_00446 1046629.Ssal_00984 1.7e-37 161.4 Bacilli ko:K07491 ko00000 Bacteria 1TSQ0@1239,4HDZ0@91061,COG1943@1,COG1943@2 NA|NA|NA L COG1943 Transposase and inactivated derivatives HLLCKODE_00447 1046629.Ssal_02111 6.8e-204 716.5 Bacilli recA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009292,GO:0009294,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030420,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0046483,GO:0050896,GO:0051704,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360 ko:K03553 ko03440,map03440 M00729 ko00000,ko00001,ko00002,ko03400 Bacteria 1TPD5@1239,4HAG5@91061,COG0468@1,COG0468@2 NA|NA|NA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage HLLCKODE_00448 1046629.Ssal_02112 5.3e-226 790.0 Bacilli cinA GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363 3.5.1.42 ko:K03742,ko:K03743 ko00760,map00760 R02322 RC00100 ko00000,ko00001,ko01000 Bacteria 1TQ1N@1239,4HATN@91061,COG1058@1,COG1058@2,COG1546@1,COG1546@2 NA|NA|NA S Belongs to the CinA family HLLCKODE_00449 904306.HMPREF9192_0031 5.1e-104 383.6 Bacilli tag 3.2.2.20 ko:K01246 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 1V9B8@1239,4HJ4I@91061,COG2818@1,COG2818@2 NA|NA|NA L 3-methyladenine DNA glycosylase HLLCKODE_00450 1046629.Ssal_02114 1.7e-102 378.6 Bacilli ruvA GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 ko:K03550 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 1V3KF@1239,4HHI5@91061,COG0632@1,COG0632@2 NA|NA|NA L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB HLLCKODE_00452 1046629.Ssal_02116 0.0 1238.4 Bacilli mutL GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0032300,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1990391 ko:K03572 ko03430,map03430 ko00000,ko00001,ko03400 Bacteria 1TPGK@1239,4HB34@91061,COG0323@1,COG0323@2 NA|NA|NA L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex HLLCKODE_00454 904306.HMPREF9192_0027 1.6e-68 265.4 Bacilli Bacteria 1VE2H@1239,4IPMG@91061,COG3279@1,COG3279@2 NA|NA|NA K LytTr DNA-binding domain HLLCKODE_00455 1046629.Ssal_02119 1.1e-77 295.8 Bacilli Bacteria 1VHBQ@1239,2E0UI@1,32WBZ@2,4HRYH@91061 NA|NA|NA S Protein of unknown function (DUF3021) HLLCKODE_00456 904306.HMPREF9192_0025 0.0 1620.1 Bacilli mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 ko:K03555 ko03430,map03430 ko00000,ko00001,ko03400 Bacteria 1TPRJ@1239,4HA63@91061,COG0249@1,COG0249@2 NA|NA|NA L that it carries out the mismatch recognition step. This protein has a weak ATPase activity HLLCKODE_00457 1046629.Ssal_02121 2e-53 214.9 Bacilli ymcA 3.6.3.21 ko:K02028 M00236 ko00000,ko00002,ko01000,ko02000 3.A.1.3 Bacteria 1V4W0@1239,4HH6Y@91061,COG4550@1,COG4550@2 NA|NA|NA S Belongs to the UPF0342 family HLLCKODE_00458 904306.HMPREF9192_0023 3.4e-68 264.2 Bacilli argR GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 ko:K03402 ko00000,ko03000 Bacteria 1V1R7@1239,4HFY8@91061,COG1438@1,COG1438@2 NA|NA|NA K Regulates arginine biosynthesis genes HLLCKODE_00459 435842.HMPREF0848_01943 0.0 1108.6 Bacilli argS 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Bacteria 1TPEZ@1239,4HAR3@91061,COG0018@1,COG0018@2 NA|NA|NA J Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA HLLCKODE_00460 264199.stu0045 8.1e-246 855.9 Bacilli purB GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 iLJ478.TM1095,iSB619.SA_RS09895 Bacteria 1TPMM@1239,4HACW@91061,COG0015@1,COG0015@2 NA|NA|NA F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily HLLCKODE_00461 592010.GCWU000182_001684 2.1e-84 318.9 Bacilli Bacteria 1UPXI@1239,2AXCI@1,31PBS@2,4HTUK@91061 NA|NA|NA HLLCKODE_00463 585203.SMSK564_1384 1.9e-33 147.9 Streptococcus mitis Bacteria 1VIUY@1239,2DZH9@1,2TPYM@28037,32VAR@2,4HZSZ@91061 NA|NA|NA HLLCKODE_00464 888833.HMPREF9421_0376 2.2e-171 608.2 Firmicutes 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 Bacteria 1UD8U@1239,COG1893@1,COG1893@2 NA|NA|NA H Ketopantoate reductase HLLCKODE_00465 904306.HMPREF9192_0016 1.3e-199 702.2 Bacilli purK 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQCD@1239,4H9M5@91061,COG0026@1,COG0026@2 NA|NA|NA F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) HLLCKODE_00466 1005705.HMPREF9967_0320 5.3e-81 307.0 Streptococcus infantis purE GO:0003674,GO:0003824,GO:0004638,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0016853,GO:0016866,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034023,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 iETEC_1333.ETEC_0575,iJN746.PP_5336,iPC815.YPO3076,iUTI89_1310.UTI89_C0551 Bacteria 1V1MV@1239,43FX6@68892,4HFR7@91061,COG0041@1,COG0041@2 NA|NA|NA F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) HLLCKODE_00467 435842.HMPREF0848_01948 1.4e-237 828.6 Bacilli purD 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS05245,iYO844.BSU06530 Bacteria 1UHN9@1239,4HA70@91061,COG0151@1,COG0151@2 NA|NA|NA F Belongs to the GARS family HLLCKODE_00468 1046629.Ssal_01740 4.1e-158 563.9 Bacilli ko:K21471 ko00000,ko01000,ko01002,ko01011 Bacteria 1VUNU@1239,4HVY0@91061,COG3942@1,COG3942@2 NA|NA|NA S CHAP domain HLLCKODE_00469 1046629.Ssal_02136 5.6e-294 1016.1 Bacilli purH GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 iJN678.purH Bacteria 1TPQ5@1239,4H9YY@91061,COG0138@1,COG0138@2 NA|NA|NA F Bifunctional purine biosynthesis protein PurH HLLCKODE_00470 264199.stu0034 7.6e-100 369.8 Bacilli purN 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 Bacteria 1V3RJ@1239,4HGY5@91061,COG0299@1,COG0299@2 NA|NA|NA F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate HLLCKODE_00471 435842.HMPREF0848_01955 2.5e-189 667.9 Bacilli purM GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.1,6.3.4.13 ko:K01933,ko:K11788 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144,R04208 RC00090,RC00166,RC01100 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1844,iECSF_1327.ECSF_2340 Bacteria 1TP9J@1239,4HABW@91061,COG0150@1,COG0150@2 NA|NA|NA F Phosphoribosylformylglycinamidine cyclo-ligase HLLCKODE_00472 435842.HMPREF0848_01956 3e-273 947.2 Bacilli purF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 iSB619.SA_RS05225 Bacteria 1TPH3@1239,4HAXU@91061,COG0034@1,COG0034@2 NA|NA|NA F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine HLLCKODE_00473 904306.HMPREF9192_0008 0.0 2404.4 Bacilli purL 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPAS@1239,4HB3N@91061,COG0046@1,COG0046@2,COG0047@1,COG0047@2 NA|NA|NA F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL HLLCKODE_00474 1046629.Ssal_02141 2.2e-128 464.9 Bacilli purC GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016874,GO:0016879,GO:0016881,GO:0044424,GO:0044444,GO:0044464 4.1.1.21,4.3.2.2,6.3.2.6 ko:K01587,ko:K01756,ko:K01923 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04209,R04559,R04591 RC00064,RC00162,RC00379,RC00444,RC00445,RC00590 ko00000,ko00001,ko00002,ko01000 iAF1260.b2476,iB21_1397.B21_02330,iBWG_1329.BWG_2240,iE2348C_1286.E2348C_2713,iEC042_1314.EC042_2677,iEC55989_1330.EC55989_2759,iECABU_c1320.ECABU_c27880,iECBD_1354.ECBD_1213,iECB_1328.ECB_02368,iECDH10B_1368.ECDH10B_2642,iECDH1ME8569_1439.ECDH1ME8569_2402,iECDH1ME8569_1439.EcDH1_1193,iECD_1391.ECD_02368,iECED1_1282.ECED1_2911,iECH74115_1262.ECH74115_3698,iECIAI1_1343.ECIAI1_2527,iECNA114_1301.ECNA114_2561,iECO103_1326.ECO103_2988,iECO111_1330.ECO111_3199,iECO26_1355.ECO26_3522,iECOK1_1307.ECOK1_2784,iECP_1309.ECP_2490,iECS88_1305.ECS88_2658,iECSE_1348.ECSE_2760,iECSF_1327.ECSF_2329,iECSP_1301.ECSP_3415,iECUMN_1333.ECUMN_2789,iECW_1372.ECW_m2698,iECs_1301.ECs3338,iEKO11_1354.EKO11_1259,iETEC_1333.ETEC_2581,iEcDH1_1363.EcDH1_1193,iEcE24377_1341.EcE24377A_2757,iEcHS_1320.EcHS_A2607,iEcSMS35_1347.EcSMS35_2623,iEcolC_1368.EcolC_1200,iG2583_1286.G2583_2999,iJN746.PP_1240,iJO1366.b2476,iJR904.b2476,iLF82_1304.LF82_1775,iNRG857_1313.NRG857_12360,iSFV_1184.SFV_2521,iSF_1195.SF2519,iSFxv_1172.SFxv_2773,iS_1188.S2669,iSbBS512_1146.SbBS512_E2848,iUMNK88_1353.UMNK88_3071,iWFL_1372.ECW_m2698,iY75_1357.Y75_RS12925,iYL1228.KPN_02810,iZ_1308.Z3735 Bacteria 1TP11@1239,4H9U8@91061,COG0152@1,COG0152@2 NA|NA|NA F Belongs to the SAICAR synthetase family HLLCKODE_00475 435842.HMPREF0848_01959 4.8e-30 136.7 Bacteria acpP1 ko:K02078 ko00000,ko00001 Bacteria COG0236@1,COG0236@2 NA|NA|NA IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis HLLCKODE_00476 1046629.Ssal_02143 2.3e-182 644.8 Bacilli plsX GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 1TPXS@1239,4HA0R@91061,COG0416@1,COG0416@2 NA|NA|NA I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA HLLCKODE_00477 904306.HMPREF9192_0004 3.7e-137 494.2 Bacilli recO GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 ko:K03584 ko03440,map03440 ko00000,ko00001,ko03400 Bacteria 1UZ19@1239,4HAHI@91061,COG1381@1,COG1381@2 NA|NA|NA L Involved in DNA repair and RecF pathway recombination HLLCKODE_00478 1046629.Ssal_02145 6.7e-215 753.1 Bacilli araT 2.6.1.1 ko:K00812,ko:K00841,ko:K10907 ko00220,ko00250,ko00270,ko00300,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00300,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 M00525 R00355,R00694,R00734,R00896,R02433,R02619,R04467,R05052 RC00006 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 1TP0J@1239,4HA13@91061,COG0436@1,COG0436@2 NA|NA|NA E Aminotransferase HLLCKODE_00479 1046629.Ssal_02148 9.5e-175 619.4 Bacilli prs 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2848 Bacteria 1TQ6Q@1239,4HB61@91061,COG0462@1,COG0462@2 NA|NA|NA F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) HLLCKODE_00480 1046629.Ssal_02149 4.7e-83 315.5 Bacilli usp 3.5.1.28 ko:K21471,ko:K22409 ko00000,ko01000,ko01002,ko01011 CBM50 Bacteria 1VCXB@1239,4IS6H@91061,COG3883@1,COG3883@2,COG3942@1,COG3942@2 NA|NA|NA S CHAP domain HLLCKODE_00481 1046629.Ssal_02150 1.4e-82 312.4 Bacilli mreD GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944 ko:K03571 ko00000,ko03036 9.B.157.1 Bacteria 1VEN7@1239,4HNAD@91061,COG2891@1,COG2891@2 NA|NA|NA M rod shape-determining protein MreD HLLCKODE_00482 322159.STER_0040 4.9e-111 407.5 Bacilli mreC GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007163,GO:0008150,GO:0008360,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0030428,GO:0031224,GO:0031226,GO:0042546,GO:0043621,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071554,GO:0071840,GO:0071944,GO:0071963 ko:K03570 ko00000,ko03036 9.B.157.1 Bacteria 1TR1V@1239,4HB0K@91061,COG1792@1,COG1792@2 NA|NA|NA M Involved in formation and maintenance of cell shape HLLCKODE_00488 1198676.SMUGS5_00840 2.6e-10 69.7 Firmicutes Bacteria 1VP0T@1239,2EG8N@1,33A0G@2 NA|NA|NA HLLCKODE_00500 904306.HMPREF9192_0340 1.4e-256 891.7 Bacilli gdhA 1.4.1.4 ko:K00262 ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100 R00248 RC00006,RC02799 ko00000,ko00001,ko01000 Bacteria 1TP45@1239,4HAEI@91061,COG0334@1,COG0334@2 NA|NA|NA E Belongs to the Glu Leu Phe Val dehydrogenases family HLLCKODE_00501 1046629.Ssal_01767 1.2e-267 928.7 Bacilli Bacteria 1VS0Z@1239,4HJQE@91061,COG5617@1,COG5617@2 NA|NA|NA S Psort location CytoplasmicMembrane, score HLLCKODE_00502 1046629.Ssal_01766 7.9e-70 269.6 Bacilli def_1 3.5.1.31,3.5.1.88 ko:K01450,ko:K01462 ko00270,ko00630,map00270,map00630 R00653 RC00165,RC00323 ko00000,ko00001,ko01000 Bacteria 1V73T@1239,4HGYC@91061,COG0242@1,COG0242@2 NA|NA|NA J Removes the formyl group from the N-terminal Met of newly synthesized proteins HLLCKODE_00503 264199.stu0432 3.7e-73 280.8 Bacteria Bacteria COG1846@1,COG1846@2 NA|NA|NA K DNA-binding transcription factor activity HLLCKODE_00504 1046629.Ssal_01764 4e-307 1060.1 Bacilli lmrA1 ko:K02021,ko:K06147,ko:K06148,ko:K18887 ko02010,map02010 M00706 ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21 Bacteria 1TP0B@1239,4H9SC@91061,COG1132@1,COG1132@2 NA|NA|NA V abc transporter atp-binding protein HLLCKODE_00505 1046629.Ssal_01763 0.0 1099.7 Bacilli lmrA2 ko:K06147 ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 1TP0B@1239,4HA3S@91061,COG1132@1,COG1132@2 NA|NA|NA V abc transporter atp-binding protein HLLCKODE_00506 1046629.Ssal_01762 1.4e-110 405.6 Bacilli Bacteria 1VF01@1239,4HPKN@91061,COG0454@1,COG0456@2 NA|NA|NA K Acetyltransferase (GNAT) family HLLCKODE_00507 1046629.Ssal_01761 4.8e-111 407.1 Bacilli 2.7.6.5 ko:K00951,ko:K07816 ko00230,map00230 R00429 RC00002,RC00078 ko00000,ko00001,ko01000 Bacteria 1TQ2F@1239,4HTR5@91061,COG2357@1,COG2357@2 NA|NA|NA S Region found in RelA / SpoT proteins HLLCKODE_00508 1046629.Ssal_01760 2.7e-115 421.4 Bacilli Bacteria 1TPU2@1239,4HG2E@91061,COG0745@1,COG0745@2 NA|NA|NA T response regulator HLLCKODE_00509 1046629.Ssal_01758 1.2e-209 735.7 Bacilli sptS 2.7.13.3 ko:K11328 ko02020,map02020 M00464 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1UHQH@1239,4HAHG@91061,COG0642@1,COG0642@2 NA|NA|NA T Histidine kinase HLLCKODE_00510 1046629.Ssal_01757 1.7e-131 475.3 Bacilli pyrH GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006225,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009163,GO:0009165,GO:0009185,GO:0009188,GO:0009193,GO:0009194,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0033862,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042455,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046048,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 R00158 RC00002 ko00000,ko00001,ko01000 iSB619.SA_RS06240 Bacteria 1TPXN@1239,4H9UB@91061,COG0528@1,COG0528@2 NA|NA|NA F Catalyzes the reversible phosphorylation of UMP to UDP HLLCKODE_00511 904306.HMPREF9192_0351 6.4e-91 340.1 Bacilli frr GO:0002181,GO:0002184,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0030312,GO:0032984,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02838 ko00000,ko03012 Bacteria 1V1F2@1239,4HFSH@91061,COG0233@1,COG0233@2 NA|NA|NA J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another HLLCKODE_00512 1046629.Ssal_01755 1.3e-159 568.9 Bacilli cvfB ko:K00243 ko00000 Bacteria 1TQ1Z@1239,4HDAZ@91061,COG2996@1,COG2996@2 NA|NA|NA S Protein conserved in bacteria HLLCKODE_00513 904306.HMPREF9192_0353 3.7e-34 150.2 Bacilli yozE Bacteria 1VFI4@1239,4HR7P@91061,COG4479@1,COG4479@2 NA|NA|NA S Belongs to the UPF0346 family HLLCKODE_00514 1046629.Ssal_01753 1.5e-130 473.0 Bacilli sip Bacteria 1V61Q@1239,4HHT0@91061,COG1388@1,COG1388@2 NA|NA|NA M LysM domain protein HLLCKODE_00515 322159.STER_0480 2e-186 658.3 Bacilli phoH GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K06217 ko00000 Bacteria 1TP35@1239,4HBD5@91061,COG1702@1,COG1702@2 NA|NA|NA T phosphate starvation-inducible protein PhoH HLLCKODE_00520 904306.HMPREF9192_0360 0.0 1333.9 Bacilli metG GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10,6.1.1.20 ko:K01874,ko:K01890,ko:K06878 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R03660,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1TPA1@1239,4H9VC@91061,COG0073@1,COG0073@2,COG0143@1,COG0143@2 NA|NA|NA J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation HLLCKODE_00521 435842.HMPREF0848_00069 9.3e-158 562.8 Bacilli Bacteria 1TPM1@1239,4H9XJ@91061,COG0656@1,COG0656@2 NA|NA|NA S reductase HLLCKODE_00522 1046629.Ssal_01743 4.7e-168 597.0 Bacilli Bacteria 1V53I@1239,4HIEU@91061,COG0583@1,COG0583@2 NA|NA|NA K transcriptional regulator (lysR family) HLLCKODE_00523 435842.HMPREF0848_00071 9.4e-106 389.8 Firmicutes ko:K07052 ko00000 Bacteria 1VCV8@1239,COG1266@1,COG1266@2 NA|NA|NA S CAAX amino terminal protease family protein HLLCKODE_00524 435842.HMPREF0848_00072 7.1e-262 909.8 Bacteria 2.7.13.3,2.7.7.7,5.4.99.21 ko:K02343,ko:K03407,ko:K06182,ko:K08372,ko:K12065,ko:K16291 ko00230,ko00240,ko01100,ko02020,ko02030,ko03030,ko03430,ko03440,map00230,map00240,map01100,map02020,map02030,map03030,map03430,map03440 M00260,M00506 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko01001,ko01002,ko01011,ko02022,ko02035,ko02044,ko03009,ko03032,ko03400 3.A.7.11.1 Bacteria COG3087@1,COG3087@2 NA|NA|NA D Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides HLLCKODE_00525 1046629.Ssal_01737 2.4e-162 578.2 Bacilli coiA 3.6.4.12 ko:K03657,ko:K06198 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 1TRGD@1239,4HFP5@91061,COG4469@1,COG4469@2 NA|NA|NA S Competence protein HLLCKODE_00526 1046629.Ssal_01736 0.0 1188.3 Bacilli pepF GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006465,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0051604,GO:0070011,GO:0071704,GO:0140096,GO:1901564 ko:K08602 ko00000,ko01000,ko01002 Bacteria 1TP4P@1239,4HA7X@91061,COG1164@1,COG1164@2 NA|NA|NA E oligoendopeptidase F HLLCKODE_00527 904306.HMPREF9192_0364 5e-213 746.9 Bacilli oxlT ko:K08177 ko00000,ko02000 2.A.1.11 Bacteria 1TPR9@1239,4HB93@91061,COG2223@1,COG2223@2 NA|NA|NA P COG0477 Permeases of the major facilitator superfamily HLLCKODE_00528 1046629.Ssal_01734 6.1e-120 436.8 Bacilli yrrM 2.1.1.104 ko:K00588 ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110 M00039,M00350 R01942,R06578 RC00003,RC00392 ko00000,ko00001,ko00002,ko01000 Bacteria 1UF4M@1239,4HE9E@91061,COG4122@1,COG4122@2 NA|NA|NA S O-Methyltransferase HLLCKODE_00529 1046629.Ssal_01733 2.3e-167 595.1 Bacteria prsA 3.1.3.16,5.2.1.8 ko:K01802,ko:K03769,ko:K07533,ko:K20074 ko00000,ko01000,ko01009,ko03110 Bacteria COG0760@1,COG0760@2 NA|NA|NA O peptidyl-prolyl cis-trans isomerase activity HLLCKODE_00530 435842.HMPREF0848_00077 4.6e-85 320.5 Bacilli yxjI ko:K21429 ko00000,ko01002 Bacteria 1VBT3@1239,4HH8W@91061,COG4894@1,COG4894@2 NA|NA|NA S LURP-one-related HLLCKODE_00531 1046629.Ssal_01730 0.0 1713.0 Bacilli alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1TPK6@1239,4H9XC@91061,COG0013@1,COG0013@2 NA|NA|NA J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain HLLCKODE_00532 862970.SAIN_0380 2.7e-122 444.9 Bacilli ko:K03496 ko00000,ko03036,ko04812 Bacteria 1V6Q6@1239,4HINH@91061,COG1192@1,COG1192@2 NA|NA|NA D CobQ CobB MinD ParA nucleotide binding domain protein HLLCKODE_00535 1035189.HMPREF9954_1823 2.1e-10 72.4 Streptococcus infantis Bacteria 1TWK4@1239,2DIZ9@1,304EA@2,43GGZ@68892,4I5DS@91061 NA|NA|NA HLLCKODE_00536 862970.SAIN_0378 3.3e-209 734.9 Bacteria Bacteria COG4487@1,COG4487@2 NA|NA|NA I mechanosensitive ion channel activity HLLCKODE_00537 1035189.HMPREF9954_1821 3.2e-22 110.9 Streptococcus infantis Bacteria 1TWKS@1239,2DIZK@1,304EN@2,43GIZ@68892,4I5EI@91061 NA|NA|NA S BRCA1 C Terminus (BRCT) domain HLLCKODE_00540 388919.SSA_0155 4.9e-16 90.5 Streptococcus sanguinis Bacteria 1UACV@1239,1WS5P@1305,2AR9W@1,31GJT@2,4IKR3@91061 NA|NA|NA S Uncharacterized protein pXO2-11 HLLCKODE_00541 1035189.HMPREF9954_1819 8.4e-41 174.1 Streptococcus infantis Bacteria 1TWJ2@1239,2DIYX@1,304DP@2,43GDZ@68892,4I5CJ@91061 NA|NA|NA HLLCKODE_00542 862970.SAIN_0384 8e-298 1029.2 Bacilli trsE Bacteria 1W186@1239,4HA4T@91061,COG0433@1,COG0433@2 NA|NA|NA S COG0433 Predicted ATPase HLLCKODE_00544 862970.SAIN_0386 2e-162 578.9 Bacteria 3.4.17.14 ko:K02395,ko:K07260 ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020 M00651 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504,ko02035 Bacteria COG1705@1,COG1705@2 NA|NA|NA NU amidase activity HLLCKODE_00545 997830.HMPREF1124_0866 1.7e-25 122.9 Streptococcus infantis Bacteria 1TWJM@1239,2DIZ3@1,304E1@2,43GFK@68892,4I5D6@91061 NA|NA|NA HLLCKODE_00547 997830.HMPREF1124_0825 5.7e-32 144.1 Streptococcus infantis Bacteria 1TWKB@1239,2BKU4@1,32FAD@2,43GHI@68892,4I5E1@91061 NA|NA|NA HLLCKODE_00548 862970.SAIN_0355 1.1e-201 709.5 Bacilli repE Bacteria 1UBUD@1239,4HB0A@91061,COG1959@1,COG1959@2 NA|NA|NA K Primase C terminal 1 (PriCT-1) HLLCKODE_00550 997830.HMPREF1124_0830 5.5e-12 77.0 Streptococcus infantis Bacteria 1TWJQ@1239,2DIZ5@1,304E3@2,43GFN@68892,4I5D8@91061 NA|NA|NA HLLCKODE_00551 1035189.HMPREF9954_1860 1.8e-16 92.4 Streptococcus infantis Bacteria 1TWK7@1239,2DIZC@1,304ED@2,43GH6@68892,4I5DW@91061 NA|NA|NA S Thioredoxin HLLCKODE_00553 997830.HMPREF1124_0834 2.1e-73 282.7 Streptococcus infantis Bacteria 1W27X@1239,2DCHT@1,2ZE7E@2,43GGG@68892,4I25E@91061 NA|NA|NA HLLCKODE_00555 1035189.HMPREF9954_1855 1.6e-18 99.0 Streptococcus infantis Bacteria 1TWM0@1239,29P5X@1,30A42@2,43GJG@68892,4I5ET@91061 NA|NA|NA S the current gene model (or a revised gene model) may contain a frame shift HLLCKODE_00556 1035189.HMPREF9954_1854 3.5e-34 151.0 Streptococcus infantis Bacteria 1TWKR@1239,2DIZJ@1,304EM@2,43GIX@68892,4I5EH@91061 NA|NA|NA S the current gene model (or a revised gene model) may contain a frame shift HLLCKODE_00557 1161413.HMPREF1510_1733 4.6e-103 380.9 Bacilli ada 3.2.2.21 ko:K13529,ko:K15051 ko03410,map03410 ko00000,ko00001,ko01000,ko03000,ko03400 Bacteria 1TR37@1239,4HHHQ@91061,COG2169@1,COG2169@2 NA|NA|NA F DNA/RNA non-specific endonuclease HLLCKODE_00558 997830.HMPREF1124_0841 2.5e-19 102.1 Streptococcus infantis Bacteria 1TWM2@1239,2DIZQ@1,304EU@2,43GJQ@68892,4I5EW@91061 NA|NA|NA HLLCKODE_00559 1161413.HMPREF1510_1730 2.6e-210 738.8 Bacilli ruvB 3.6.4.12 ko:K03551,ko:K07126 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 1V0DS@1239,4HENV@91061,COG2255@1,COG2255@2 NA|NA|NA L four-way junction helicase activity HLLCKODE_00562 862970.SAIN_0361 0.0 1131.3 Streptococcus anginosus group Bacteria 1TRTK@1239,42EIH@671232,4ISSX@91061,COG0358@1,COG0358@2,COG2856@1,COG2856@2 NA|NA|NA EL Toprim-like HLLCKODE_00564 862970.SAIN_0362 1e-190 673.3 Bacilli topB 5.99.1.2 ko:K03169 ko00000,ko01000,ko03032 Bacteria 1TPJD@1239,4HAZV@91061,COG0550@1,COG0550@2 NA|NA|NA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone HLLCKODE_00565 862970.SAIN_0363 2.6e-245 854.7 Bacilli clpB ko:K03694,ko:K03695,ko:K03696 ko01100,ko04213,map01100,map04213 ko00000,ko00001,ko03110 Bacteria 1TPMU@1239,4HACY@91061,COG0542@1,COG0542@2 NA|NA|NA O Belongs to the ClpA ClpB family HLLCKODE_00566 1035189.HMPREF9954_1835 3.7e-17 94.4 Streptococcus infantis Bacteria 1TWKN@1239,2DIZG@1,304EJ@2,43GIM@68892,4I5EE@91061 NA|NA|NA HLLCKODE_00567 862970.SAIN_0365 2.2e-95 355.9 Streptococcus anginosus group Bacteria 1TW0G@1239,2DIU0@1,3044E@2,42EHD@671232,4I4P6@91061 NA|NA|NA HLLCKODE_00569 1000588.HMPREF9965_0485 4.9e-15 89.7 Streptococcus mitis ko:K03442 ko00000,ko02000 1.A.23.2 Bacteria 1UN49@1239,2TQ2Z@28037,4IU67@91061,COG3064@1,COG3064@2 NA|NA|NA M LPXTG cell wall anchor motif HLLCKODE_00571 862970.SAIN_0374 0.0 1357.4 Bacilli ko:K03205 ko03070,map03070 M00333 ko00000,ko00001,ko00002,ko02044 3.A.7 Bacteria 1TPCF@1239,4H9ZN@91061,COG3505@1,COG3505@2 NA|NA|NA U COG3505 Type IV secretory pathway, VirD4 components HLLCKODE_00572 1116231.SMA_1998 2.7e-63 248.4 Bacilli tnpR Bacteria 1UZM8@1239,4IQ67@91061,COG1961@1,COG1961@2 NA|NA|NA L Resolvase, N terminal domain HLLCKODE_00574 1046629.Ssal_02044 8.6e-87 326.2 Bacteria sigH ko:K03088,ko:K03091,ko:K12296 ko02020,ko02024,map02020,map02024 ko00000,ko00001,ko03000,ko03021 Bacteria COG1595@1,COG1595@2 NA|NA|NA K DNA-templated transcription, initiation HLLCKODE_00575 1046629.Ssal_02043 5.5e-136 490.3 Bacilli ykuT GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0006810,GO:0006950,GO:0006970,GO:0008150,GO:0008381,GO:0009628,GO:0009987,GO:0015267,GO:0022803,GO:0022836,GO:0022857,GO:0033554,GO:0042802,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071214,GO:0071470,GO:0104004 ko:K22044 ko00000,ko02000 1.A.23.3 Bacteria 1TR9Z@1239,4HCB8@91061,COG0668@1,COG0668@2 NA|NA|NA M mechanosensitive ion channel HLLCKODE_00576 1046629.Ssal_02041 5.8e-228 796.6 Bacilli tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 ko:K03545 ko00000 Bacteria 1TQQ8@1239,4H9Q8@91061,COG0544@1,COG0544@2 NA|NA|NA D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase HLLCKODE_00577 1046629.Ssal_02039 1.3e-70 272.7 Bacilli rpoE GO:0003674,GO:0003824,GO:0003899,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 ko:K03048 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko03021,ko03400 Bacteria 1V6WX@1239,4HIUK@91061,COG3343@1,COG3343@2 NA|NA|NA K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling HLLCKODE_00578 1046629.Ssal_02036 1e-306 1058.5 Bacilli pyrG GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS01075,iNJ661.Rv1699 Bacteria 1TP34@1239,4H9X6@91061,COG0504@1,COG0504@2 NA|NA|NA F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates HLLCKODE_00579 1046629.Ssal_02035 8.4e-84 316.2 Bacilli XK27_03960 Bacteria 1VFZQ@1239,2E0MY@1,32W75@2,4HKWR@91061 NA|NA|NA S Protein of unknown function (DUF3013) HLLCKODE_00580 435842.HMPREF0848_01471 2.7e-74 284.6 Bacilli mutT3 3.6.1.13,3.6.1.55 ko:K01515,ko:K03574 ko00230,map00230 R01054 RC00002 ko00000,ko00001,ko01000,ko03400 Bacteria 1V8D5@1239,4HJKW@91061,COG0494@1,COG0494@2 NA|NA|NA L NUDIX domain HLLCKODE_00581 1046629.Ssal_02032 2.6e-177 627.9 Bacilli prmA ko:K02687 ko00000,ko01000,ko03009 Bacteria 1TPKI@1239,4HAMF@91061,COG2264@1,COG2264@2 NA|NA|NA J Ribosomal protein L11 methyltransferase HLLCKODE_00582 1046629.Ssal_02031 3.2e-130 471.1 Bacilli rsmE GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070042,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.193 ko:K09761 ko00000,ko01000,ko03009 Bacteria 1V1CT@1239,4HH8P@91061,COG1385@1,COG1385@2 NA|NA|NA J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit HLLCKODE_00583 435842.HMPREF0848_01474 0.0 1418.7 Bacilli cpdB GO:0003674,GO:0003824,GO:0004112,GO:0005575,GO:0005623,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0008252,GO:0008254,GO:0008663,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0030288,GO:0030313,GO:0031975,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0042597,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.1.3.6,3.1.4.16 ko:K01119 ko00230,ko00240,map00230,map00240 R01562,R01877,R02148,R02370,R03537,R03538,R03929,R05135 RC00078,RC00296 ko00000,ko00001,ko01000 iEC55989_1330.EC55989_4773,iECH74115_1262.ECH74115_5730,iECNA114_1301.ECNA114_4436,iECSP_1301.ECSP_5315,iECW_1372.ECW_m4577,iECs_1301.ECs5191,iEKO11_1354.EKO11_4095,iEcE24377_1341.EcE24377A_4783,iG2583_1286.G2583_5043,iWFL_1372.ECW_m4577,iZ_1308.Z5824 Bacteria 1TPV2@1239,4HB9S@91061,COG0737@1,COG0737@2 NA|NA|NA F Belongs to the 5'-nucleotidase family HLLCKODE_00584 1046629.Ssal_02029 4.1e-83 313.9 Bacilli nrdI ko:K03647 ko00000 Bacteria 1V71V@1239,4HIW7@91061,COG1780@1,COG1780@2 NA|NA|NA F Belongs to the NrdI family HLLCKODE_00585 1046629.Ssal_02028 0.0 1433.7 Bacilli relA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009605,GO:0009987,GO:0009991,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5 ko:K00951 ko00230,map00230 R00429 RC00002,RC00078 ko00000,ko00001,ko01000 iHN637.CLJU_RS16615,iYO844.BSU27600 Bacteria 1TNYZ@1239,4HBX7@91061,COG0317@1,COG0317@2 NA|NA|NA KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance HLLCKODE_00586 1046629.Ssal_02026 1.4e-75 288.9 Bacilli dtd GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106026,GO:0106074,GO:0140098,GO:0140101,GO:1901360 ko:K07560 ko00000,ko01000,ko03016 Bacteria 1V6GH@1239,4HINN@91061,COG1490@1,COG1490@2 NA|NA|NA J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality HLLCKODE_00587 1046629.Ssal_02025 0.0 1675.6 Bacilli dex 3.2.1.11 ko:K05988 ko00500,map00500 R11309 ko00000,ko00001,ko01000 GH66 Bacteria 1TS2G@1239,4HF5J@91061,COG5297@1,COG5297@2 NA|NA|NA G Glycosyl hydrolase family 66 HLLCKODE_00588 1046629.Ssal_02023 8.7e-237 825.9 Bacilli ilvA GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP22@1239,4H9NK@91061,COG1171@1,COG1171@2 NA|NA|NA E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA HLLCKODE_00589 904306.HMPREF9192_0243 1.9e-112 411.8 Bacilli def GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.31,3.5.1.88 ko:K01450,ko:K01462 ko00270,ko00630,map00270,map00630 R00653 RC00165,RC00323 ko00000,ko00001,ko01000 Bacteria 1V5C6@1239,4HGUI@91061,COG0242@1,COG0242@2 NA|NA|NA J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions HLLCKODE_00590 1046629.Ssal_02021 5.3e-105 387.1 Bacilli fnr5 Bacteria 1V2AH@1239,4HFNC@91061,COG0664@1,COG0664@2 NA|NA|NA K Catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases HLLCKODE_00591 1046629.Ssal_02020 1.3e-181 642.5 Bacilli yhjX ko:K03449,ko:K08177 ko00000,ko02000 2.A.1.11,2.A.1.17 Bacteria 1TSM5@1239,4HF98@91061,COG2807@1,COG2807@2 NA|NA|NA P Major Facilitator HLLCKODE_00592 435842.HMPREF0848_01487 5.4e-43 179.9 Bacilli rpsO GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016071,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031123,GO:0031124,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02956 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1VA5C@1239,4HKE9@91061,COG0184@1,COG0184@2 NA|NA|NA J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome HLLCKODE_00593 1046629.Ssal_02018 1.7e-81 308.9 Bacilli Bacteria 1VM0K@1239,4HVBZ@91061,COG4767@1,COG4767@2 NA|NA|NA V VanZ like family HLLCKODE_00594 1046629.Ssal_02017 2.4e-177 629.4 Bacilli Bacteria 1VXI0@1239,4HMHC@91061,COG1196@1,COG1196@2 NA|NA|NA D nuclear chromosome segregation HLLCKODE_00595 904306.HMPREF9192_0239 2.2e-123 448.4 Bacilli glnQ ko:K17074,ko:K17076 ko02010,map02010 M00589 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3.20 Bacteria 1TNYD@1239,4H9WY@91061,COG1126@1,COG1126@2 NA|NA|NA E abc transporter atp-binding protein HLLCKODE_00596 1046629.Ssal_02015 4.3e-270 936.8 Bacilli glnP ko:K02029,ko:K02030,ko:K10040,ko:K17073,ko:K17074 ko02010,map02010 M00228,M00236,M00589 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.20 Bacteria 1TPM3@1239,4HAS2@91061,COG0765@1,COG0765@2,COG0834@1,COG0834@2 NA|NA|NA P ABC transporter HLLCKODE_00597 1046629.Ssal_02014 3.4e-152 544.3 Bacilli uppP GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0031224,GO:0031226,GO:0042221,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050380,GO:0050896,GO:0071944 3.6.1.27 ko:K06153 ko00550,map00550 R05627 RC00002 ko00000,ko00001,ko01000,ko01011 iYL1228.KPN_03461 Bacteria 1TPFA@1239,4HB0M@91061,COG1968@1,COG1968@2 NA|NA|NA V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin HLLCKODE_00598 864570.HMPREF9189_0544 8.3e-18 96.7 Bacteria Bacteria 2E7YQ@1,332D4@2 NA|NA|NA S Protein of unknown function (DUF3021) HLLCKODE_00599 1046629.Ssal_02012 2.9e-123 448.0 Bacilli mecA GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K16511 ko00000 Bacteria 1UZ7D@1239,4HID6@91061,COG4862@1,COG4862@2 NA|NA|NA NOT Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis HLLCKODE_00600 1046629.Ssal_02011 5.7e-182 643.7 Bacilli tagO GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0034645,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0045229,GO:0046872,GO:0046914,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901576 2.7.8.33,2.7.8.35 ko:K02851 R08856 RC00002 ko00000,ko01000,ko01003,ko01005 Bacteria 1TP9V@1239,4H9KT@91061,COG0472@1,COG0472@2 NA|NA|NA M transferase HLLCKODE_00601 1046629.Ssal_02010 1.7e-137 495.4 Bacilli sufC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0071840 ko:K09013 ko00000,ko02000 iECH74115_1262.ECH74115_2396,iECIAI1_1343.ECIAI1_1734,iECIAI39_1322.ECIAI39_1376,iECSP_1301.ECSP_2249,iECs_1301.ECs2389,iEcSMS35_1347.EcSMS35_1514,iG2583_1286.G2583_2077,iSFV_1184.SFV_1705,iSFxv_1172.SFxv_1919,iSSON_1240.SSON_1474,iS_1188.S1844,iZ_1308.Z2710 Bacteria 1TQ98@1239,4HAD9@91061,COG0396@1,COG0396@2 NA|NA|NA O ABC-type transport system involved in Fe-S cluster assembly, ATPase component HLLCKODE_00602 904306.HMPREF9192_0233 6.9e-234 816.2 Bacilli sufD ko:K07033,ko:K09015 ko00000 Bacteria 1TRT0@1239,4HB6W@91061,COG0719@1,COG0719@2 NA|NA|NA O assembly protein SufD HLLCKODE_00603 1046629.Ssal_02008 3.4e-233 813.9 Bacilli sufS 2.8.1.7,4.4.1.16 ko:K04487,ko:K11717 ko00450,ko00730,ko01100,ko04122,map00450,map00730,map01100,map04122 R03599,R07460,R11528,R11529 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 Bacteria 1TQ1W@1239,4HA6Z@91061,COG0520@1,COG0520@2 NA|NA|NA E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine HLLCKODE_00604 904306.HMPREF9192_0231 8e-73 279.6 Bacilli nifU GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0030003,GO:0036455,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0097428,GO:0098771,GO:1901564 ko:K04488 ko00000 Bacteria 1V3H9@1239,4HIJ0@91061,COG0822@1,COG0822@2 NA|NA|NA C SUF system FeS assembly protein, NifU family HLLCKODE_00605 904306.HMPREF9192_0230 2.9e-273 947.2 Bacilli sufB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 ko:K07033,ko:K09014 ko00000 Bacteria 1TQ21@1239,4HA1Z@91061,COG0719@1,COG0719@2 NA|NA|NA O assembly protein SufB HLLCKODE_00606 1123311.KB904471_gene1168 4.7e-26 124.0 Bacilli Bacteria 1W24H@1239,2DCPN@1,2ZEV1@2,4HZKX@91061 NA|NA|NA HLLCKODE_00607 1046629.Ssal_01995 1.8e-156 558.5 Bacilli hslO GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0031647,GO:0036506,GO:0042026,GO:0042802,GO:0043167,GO:0043169,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0065007,GO:0065008 ko:K04083 ko00000,ko03110 Bacteria 1TRCH@1239,4HAFR@91061,COG1281@1,COG1281@2 NA|NA|NA O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress HLLCKODE_00608 435842.HMPREF0848_01508 2.8e-182 644.4 Bacilli dus ko:K05540 ko00000,ko01000,ko03016 Bacteria 1TQ2R@1239,4HA9K@91061,COG0042@1,COG0042@2 NA|NA|NA J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines HLLCKODE_00609 1046629.Ssal_01993 1.9e-69 268.5 Bacilli adcR Bacteria 1VXZT@1239,4HXMU@91061,COG1846@1,COG1846@2 NA|NA|NA K transcriptional HLLCKODE_00610 1046629.Ssal_01992 2.4e-135 488.0 Bacilli adcC 3.6.3.35 ko:K09817,ko:K10830 ko02010,map02010 M00242,M00791 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15.14,3.A.1.15.2,3.A.1.15.3,3.A.1.15.5 iHN637.CLJU_RS15665,iYO844.BSU02860 Bacteria 1TQ68@1239,4HAZI@91061,COG1121@1,COG1121@2 NA|NA|NA P ABC transporter, ATP-binding protein HLLCKODE_00611 904306.HMPREF9192_0223 5.6e-128 463.8 Bacilli adcB GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0010035,GO:0010038,GO:0010043,GO:0016020,GO:0042221,GO:0044464,GO:0050896,GO:0071944 ko:K09816 ko02010,map02010 M00242 ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 Bacteria 1TR79@1239,4HC3C@91061,COG1108@1,COG1108@2 NA|NA|NA P ABC transporter (Permease HLLCKODE_00612 435842.HMPREF0848_01512 5.5e-159 567.0 Bacilli mleP2 ko:K07088 ko00000 Bacteria 1UY4N@1239,4HB48@91061,COG0679@1,COG0679@2 NA|NA|NA S Transporter, auxin efflux carrier (AEC) family protein HLLCKODE_00613 1046629.Ssal_01989 0.0 1350.1 Bacilli ptsG 2.7.1.199,2.7.1.201,2.7.1.208,2.7.1.211 ko:K02755,ko:K02756,ko:K02757,ko:K02777,ko:K02778,ko:K02779,ko:K02808,ko:K02809,ko:K02810,ko:K02817,ko:K02818,ko:K02819,ko:K20107,ko:K20108 ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111 M00265,M00266,M00268,M00269,M00270,M00271,M00272,M00303,M00806 R00811,R02738,R02780,R04111,R04394,R05132,R08559 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.1,4.A.1.1.11,4.A.1.1.12,4.A.1.2.1,4.A.1.2.10,4.A.1.2.11,4.A.1.2.12,4.A.1.2.13,4.A.1.2.2,4.A.1.2.4,4.A.1.2.5,4.A.1.2.6,4.A.1.2.8,4.A.1.2.9 Bacteria 1TPJ8@1239,4HA8X@91061,COG1263@1,COG1263@2,COG1264@1,COG1264@2,COG2190@1,COG2190@2 NA|NA|NA G pts system HLLCKODE_00614 1046629.Ssal_01988 4.6e-154 550.4 Bacilli rgfB 3.1.3.90 ko:K06896 ko00500,map00500 R10486 RC00017 ko00000,ko00001,ko01000 Bacteria 1TQZG@1239,4HGS5@91061,COG3568@1,COG3568@2 NA|NA|NA L Endonuclease/Exonuclease/phosphatase family HLLCKODE_00615 469609.HMPREF0847_00157 4.2e-253 880.2 Bacilli pgi GO:0003674,GO:0003824,GO:0004347,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 iLJ478.TM1385 Bacteria 1TP29@1239,4H9VI@91061,COG0166@1,COG0166@2 NA|NA|NA G Belongs to the GPI family HLLCKODE_00616 888821.HMPREF9394_0309 1.4e-142 512.3 Bacilli Bacteria 1TP2V@1239,4HCAG@91061,COG1028@1,COG1028@2 NA|NA|NA IQ Belongs to the short-chain dehydrogenases reductases (SDR) family HLLCKODE_00617 1419814.V470_00715 0.0 1145.6 Bacilli srlM 2.7.1.202,2.7.1.204 ko:K02768,ko:K02769,ko:K02770,ko:K03491,ko:K20112 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273,M00807 R03232,R11171 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000,ko03000 4.A.2.1,4.A.5 Bacteria 1UZ36@1239,4HDUK@91061,COG1762@1,COG1762@2,COG3711@1,COG3711@2 NA|NA|NA GKT Mga helix-turn-helix domain HLLCKODE_00618 888821.HMPREF9394_0311 6.8e-84 316.6 Bacteria gutM GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 ko:K02466 ko00000 Bacteria COG4578@1,COG4578@2 NA|NA|NA K phosphoenolpyruvate-dependent sugar phosphotransferase system HLLCKODE_00619 1297534.CAUJ01000005_gene14 1.1e-95 355.9 Bacilli srlA GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0051179,GO:0051234,GO:0071702 ko:K02783 ko00051,ko02060,map00051,map02060 M00280 R05820 RC00017,RC03206 ko00000,ko00001,ko00002,ko02000 4.A.4.1 iSBO_1134.SBO_2816 Bacteria 1URER@1239,4HEHX@91061,COG3730@1,COG3730@2 NA|NA|NA G PTS system glucitol sorbitol-specific HLLCKODE_00620 469609.HMPREF0847_00162 3.8e-179 634.0 Bacilli srlE GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0090563 2.7.1.198 ko:K02782,ko:K02783 ko00051,ko02060,map00051,map02060 M00280 R05820 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.4.1 Bacteria 1TQ8F@1239,4HA7E@91061,COG3732@1,COG3732@2 NA|NA|NA G PTS sorbitol transporter subunit IIB HLLCKODE_00621 888821.HMPREF9394_0314 4.2e-59 233.8 Bacilli srlB GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0009401,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0051179,GO:0051234,GO:0071702 2.7.1.198 ko:K02781 ko00051,ko02060,map00051,map02060 M00280 R05820 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.4.1 iB21_1397.B21_02519,iEC55989_1330.EC55989_2966,iECBD_1354.ECBD_1021,iECB_1328.ECB_02554,iECD_1391.ECD_02554,iECIAI39_1322.ECIAI39_2890,iECO111_1330.ECO111_3422,iECO26_1355.ECO26_3767,iECSE_1348.ECSE_2952,iECSP_1301.ECSP_3652,iECW_1372.ECW_m2903,iECs_1301.ECs3560,iEKO11_1354.EKO11_1071,iEcE24377_1341.EcE24377A_2988,iEcHS_1320.EcHS_A2840,iEcolC_1368.EcolC_1008,iG2583_1286.G2583_3352,iSSON_1240.SSON_2848,iWFL_1372.ECW_m2903,iZ_1308.Z4011 Bacteria 1VG8V@1239,4HMEK@91061,COG3731@1,COG3731@2 NA|NA|NA G sorbitol-specific, IIA component HLLCKODE_00622 861455.HMPREF9184_00942 8.1e-16 89.0 Bacilli tnp* Bacteria 1UHQU@1239,4IS6M@91061,COG3666@1,COG3666@2 NA|NA|NA L An automated process has identified a potential problem with this gene model HLLCKODE_00623 862967.SIR_1562 9.2e-59 232.6 Streptococcus anginosus group ko:K07493 ko00000 Bacteria 1TP4C@1239,42E7F@671232,4HAXJ@91061,COG3328@1,COG3328@2 NA|NA|NA L MULE transposase domain HLLCKODE_00624 904294.HMPREF9182_1249 1.1e-108 399.4 Bacilli Bacteria 1TQ5G@1239,4IPIE@91061,COG3547@1,COG3547@2 NA|NA|NA L Transposase IS116 IS110 IS902 HLLCKODE_00625 1123300.AUIN01000009_gene132 1.3e-305 1055.0 Bacilli glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 iNJ661.Rv3436c,iSB619.SA_RS11245,iYO844.BSU01780 Bacteria 1TPGU@1239,4H9R4@91061,COG0449@1,COG0449@2 NA|NA|NA M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source HLLCKODE_00626 904306.HMPREF9192_0472 8.2e-219 766.1 Firmicutes Bacteria 1VQIX@1239,COG3464@1,COG3464@2 NA|NA|NA L the current gene model (or a revised gene model) may contain a frame shift HLLCKODE_00627 1046629.Ssal_01986 1.4e-153 548.9 Bacteria Z012_04635 ko:K20373 ko02024,map02024 ko00000,ko00001,ko03000 Bacteria COG1396@1,COG1396@2 NA|NA|NA K sequence-specific DNA binding HLLCKODE_00628 1046629.Ssal_01985 1.1e-276 958.7 Bacilli ko:K06147,ko:K06148 ko00000,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 1TSRV@1239,4HCIZ@91061,COG1132@1,COG1132@2 NA|NA|NA V ABC transporter HLLCKODE_00629 1046629.Ssal_01984 6.1e-126 456.8 Bacilli yeeN GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 Bacteria 1TPP5@1239,4H9WJ@91061,COG0217@1,COG0217@2 NA|NA|NA K transcriptional regulatory protein HLLCKODE_00630 904306.HMPREF9192_0217 2e-47 194.9 Bacteria yajC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031522,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 Bacteria COG1862@1,COG1862@2 NA|NA|NA U protein transport HLLCKODE_00631 1046629.Ssal_01982 5.3e-141 506.9 Bacilli uppS GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 Bacteria 1TQTS@1239,4HA37@91061,COG0020@1,COG0020@2 NA|NA|NA H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids HLLCKODE_00632 1046629.Ssal_01981 4.6e-143 513.8 Bacilli cdsA GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS06255 Bacteria 1TT0Q@1239,4HAMN@91061,COG4589@1,COG4589@2 NA|NA|NA S Belongs to the CDS family HLLCKODE_00633 1046629.Ssal_01980 1.4e-229 802.0 Bacilli rseP GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016021,GO:0016787,GO:0019219,GO:0019222,GO:0019538,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0040007,GO:0043170,GO:0043856,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0045152,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:0140110,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 3.4.21.107,3.4.21.116 ko:K04771,ko:K06399,ko:K11749,ko:K16922 ko01503,ko02020,ko02024,ko04112,map01503,map02020,map02024,map04112 M00728 ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 Bacteria 1TPMC@1239,4HAQ5@91061,COG0750@1,COG0750@2 NA|NA|NA M zinc metalloprotease HLLCKODE_00634 1046629.Ssal_01979 0.0 1204.9 Bacilli proS GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0043906,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iJN678.proS,iUTI89_1310.UTI89_C0210 Bacteria 1TRBV@1239,4H9NN@91061,COG0442@1,COG0442@2 NA|NA|NA J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS HLLCKODE_00635 1046629.Ssal_01978 0.0 1101.3 Bacilli WQ51_06230 ko:K01989,ko:K05832 M00247 ko00000,ko00002,ko02000 Bacteria 1TPB0@1239,4HESK@91061,COG2984@1,COG2984@2,COG4120@1,COG4120@2 NA|NA|NA S ABC transporter HLLCKODE_00636 1046629.Ssal_01977 1.4e-142 512.3 Bacilli cmpC ko:K05833 M00247 ko00000,ko00002,ko02000 Bacteria 1TPAN@1239,4HCHC@91061,COG1101@1,COG1101@2 NA|NA|NA S abc transporter atp-binding protein HLLCKODE_00637 1046629.Ssal_01975 4.9e-42 176.8 Bacteria groS GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010468,GO:0010556,GO:0016020,GO:0016032,GO:0016465,GO:0019058,GO:0019068,GO:0019219,GO:0019222,GO:0019899,GO:0030312,GO:0031323,GO:0031326,GO:0032991,GO:0033554,GO:0034605,GO:0035375,GO:0035966,GO:0040007,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046677,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051704,GO:0051716,GO:0060255,GO:0061077,GO:0065007,GO:0071944,GO:0080090,GO:0101031,GO:1903506,GO:1990220,GO:2000112,GO:2001141 ko:K04078 ko00000,ko03029,ko03110 Bacteria COG0234@1,COG0234@2 NA|NA|NA O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter HLLCKODE_00638 1046629.Ssal_01974 1.2e-286 991.9 Bacilli groL GO:0001817,GO:0001819,GO:0001871,GO:0002791,GO:0002793,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009986,GO:0009987,GO:0016465,GO:0030246,GO:0030247,GO:0032677,GO:0032757,GO:0032879,GO:0032880,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044764,GO:0046812,GO:0048518,GO:0048522,GO:0050707,GO:0050708,GO:0050714,GO:0050715,GO:0050789,GO:0050794,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051082,GO:0051222,GO:0051223,GO:0051239,GO:0051240,GO:0051704,GO:0061077,GO:0065007,GO:0070201,GO:0090087,GO:0098630,GO:0098743,GO:0101031,GO:1903530,GO:1903532,GO:1904951,GO:1990220,GO:2000482,GO:2000484,GO:2001065 ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 Bacteria 1TP1T@1239,4HA38@91061,COG0459@1,COG0459@2 NA|NA|NA O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions HLLCKODE_00640 435842.HMPREF0848_01529 1.6e-43 181.8 Bacteria Bacteria 2C0H5@1,2ZRTJ@2 NA|NA|NA HLLCKODE_00641 1046629.Ssal_01971 4.2e-53 213.8 Bacilli Bacteria 1VKEZ@1239,4HS74@91061,COG2314@1,COG2314@2 NA|NA|NA S TM2 domain HLLCKODE_00642 1046629.Ssal_01970 5.1e-159 567.0 Bacilli rluA GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 ko:K06180 ko00000,ko01000,ko03009 Bacteria 1TSM6@1239,4HA7M@91061,COG0564@1,COG0564@2 NA|NA|NA J Responsible for synthesis of pseudouridine from uracil HLLCKODE_00643 904306.HMPREF9192_0205 0.0 1479.5 Bacilli pbp2A 2.4.1.129,3.4.16.4 ko:K05365,ko:K05366,ko:K12555,ko:K21464 ko00550,ko01100,ko01501,map00550,map01100,map01501 R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 GT51 Bacteria 1TPM5@1239,4H9SA@91061,COG0744@1,COG0744@2 NA|NA|NA M penicillin-binding protein HLLCKODE_00644 904306.HMPREF9192_0204 2.8e-24 117.1 Firmicutes secE GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K03073 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 Bacteria 1W4QH@1239,COG0690@1,COG0690@2 NA|NA|NA U Belongs to the SecE SEC61-gamma family HLLCKODE_00645 1046629.Ssal_01967 8.4e-96 356.3 Bacilli nusG GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 ko:K02601 ko00000,ko03009,ko03021 Bacteria 1TR3P@1239,4HAJA@91061,COG0250@1,COG0250@2 NA|NA|NA K Participates in transcription elongation, termination and antitermination HLLCKODE_00646 264199.stu0216 8.4e-71 273.1 Bacteria 3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27 ko:K01096,ko:K19302 ko00550,ko00564,ko01100,map00550,map00564,map01100 R02029,R05627 RC00002,RC00017 ko00000,ko00001,ko01000,ko01011 Bacteria COG0671@1,COG0671@2 NA|NA|NA I phosphatidate phosphatase activity HLLCKODE_00647 904306.HMPREF9192_0201 1.5e-144 518.8 Bacilli cof Bacteria 1TR16@1239,4HK1G@91061,COG0561@1,COG0561@2 NA|NA|NA S Sucrose-6F-phosphate phosphohydrolase HLLCKODE_00648 1046629.Ssal_01963 1.7e-134 485.3 Bacilli glcR ko:K02444,ko:K22103 ko00000,ko03000 Bacteria 1V6VV@1239,4HK1E@91061,COG1349@1,COG1349@2 NA|NA|NA K transcriptional regulator (DeoR family) HLLCKODE_00649 435842.HMPREF0848_01539 0.0 1701.4 Bacilli leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Bacteria 1TP0Y@1239,4HAG1@91061,COG0495@1,COG0495@2 NA|NA|NA J Belongs to the class-I aminoacyl-tRNA synthetase family HLLCKODE_00650 1046629.Ssal_01960 3.9e-70 270.8 Bacilli Bacteria 1V1U2@1239,4HI88@91061,COG1846@1,COG1846@2 NA|NA|NA K transcriptional HLLCKODE_00651 1046629.Ssal_01959 6.4e-222 776.5 Bacilli ko:K06889 ko00000 Bacteria 1V38K@1239,4HE7V@91061,COG1073@1,COG1073@2 NA|NA|NA S COG1073 Hydrolases of the alpha beta superfamily HLLCKODE_00652 1316408.HSISM1_348 3.2e-153 547.7 Bacilli cylA ko:K01990,ko:K11050 ko02010,map02010 M00254,M00298 ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.130 Bacteria 1V0AH@1239,4HD15@91061,COG1131@1,COG1131@2 NA|NA|NA V abc transporter atp-binding protein HLLCKODE_00653 1316408.HSISM1_347 1.1e-131 476.1 Bacilli cylB ko:K11051 ko02010,map02010 M00298 ko00000,ko00001,ko00002,ko02000 3.A.1.130 Bacteria 1TSH0@1239,4HFNX@91061,COG0842@1,COG0842@2 NA|NA|NA V ABC-2 type transporter HLLCKODE_00654 1046629.Ssal_01955 2.6e-74 284.6 Bacilli Bacteria 1VFKH@1239,4HQ50@91061,COG3279@1,COG3279@2 NA|NA|NA K COG3279 Response regulator of the LytR AlgR family HLLCKODE_00655 585203.SMSK564_0811 2.3e-32 145.2 Streptococcus mitis Bacteria 1U4EH@1239,2DKBP@1,2TPSA@28037,30949@2,4IE74@91061 NA|NA|NA S Protein of unknown function (DUF3021) HLLCKODE_00656 1046629.Ssal_01953 1.8e-122 445.3 Bacilli mta ko:K21744 ko00000,ko03000 Bacteria 1TS6Z@1239,4HCVW@91061,COG0789@1,COG0789@2 NA|NA|NA K Transcriptional HLLCKODE_00657 1046629.Ssal_01952 8.1e-120 436.4 Bacilli yhcA ko:K02003,ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 1V50G@1239,4HIB8@91061,COG1136@1,COG1136@2 NA|NA|NA V abc transporter atp-binding protein HLLCKODE_00658 1046629.Ssal_01951 2.5e-218 764.6 Bacilli macB_2 ko:K02004,ko:K05685 ko02010,map02010 M00258,M00709 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.122.1,3.A.1.122.12 Bacteria 1VU6Y@1239,4HT9M@91061,COG0577@1,COG0577@2 NA|NA|NA V FtsX-like permease family HLLCKODE_00659 435842.HMPREF0848_01550 4.3e-272 943.3 Bacilli pncB GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.21 ko:K00763 ko00760,ko01100,map00760,map01100 R01724 RC00033 ko00000,ko00001,ko01000 iYO844.BSU31750 Bacteria 1TPDW@1239,4HAI4@91061,COG1488@1,COG1488@2 NA|NA|NA H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP HLLCKODE_00660 1046629.Ssal_01948 3.8e-148 530.8 Bacilli nadE GO:0003674,GO:0003824,GO:0003952,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0016884,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0033554,GO:0034355,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043094,GO:0043173,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.1.5 ko:K01916 ko00760,ko01100,map00760,map01100 M00115 R00189 RC00100 ko00000,ko00001,ko00002,ko01000 iECSE_1348.ECSE_1910,iECW_1372.ECW_m1909,iEKO11_1354.EKO11_2035,iETEC_1333.ETEC_1772,iEcE24377_1341.EcE24377A_1961,iSFV_1184.SFV_1480,iSF_1195.SF1486,iSFxv_1172.SFxv_1676,iSSON_1240.SSON_1418,iS_1188.S1603,iWFL_1372.ECW_m1909 Bacteria 1TQ38@1239,4HA2R@91061,COG0171@1,COG0171@2 NA|NA|NA H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source HLLCKODE_00661 1046629.Ssal_01947 3.7e-73 280.8 Firmicutes yhaI Bacteria 1VDSW@1239,COG3152@1,COG3152@2 NA|NA|NA S Protein of unknown function (DUF805) HLLCKODE_00662 1046629.Ssal_01946 9.2e-253 879.0 Bacilli pepC GO:0000096,GO:0000098,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006508,GO:0006520,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0009056,GO:0009063,GO:0009636,GO:0009987,GO:0016054,GO:0016787,GO:0019538,GO:0019752,GO:0042221,GO:0043170,GO:0043418,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0050667,GO:0050896,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.4.22.40 ko:K01372 ko00000,ko01000,ko01002 Bacteria 1TRJN@1239,4HBZ9@91061,COG3579@1,COG3579@2 NA|NA|NA E aminopeptidase HLLCKODE_00663 1046629.Ssal_01944 0.0 1342.4 Bacilli ponA GO:0005575,GO:0005576 2.4.1.129,3.4.16.4 ko:K03693,ko:K05365,ko:K05366,ko:K12555,ko:K21464 ko00550,ko01100,ko01501,map00550,map01100,map01501 R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 GT51 Bacteria 1TPM5@1239,4H9SA@91061,COG0744@1,COG0744@2 NA|NA|NA M penicillin-binding protein HLLCKODE_00664 1046629.Ssal_01943 4.3e-109 400.6 Bacilli recU GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 ko:K03700 ko00000,ko03400 Bacteria 1V3S4@1239,4HGZ7@91061,COG3331@1,COG3331@2 NA|NA|NA L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation HLLCKODE_00665 1046629.Ssal_01942 3.7e-93 347.4 Bacilli ypsA Bacteria 1V5Q7@1239,4HECZ@91061,COG4474@1,COG4474@2 NA|NA|NA S Belongs to the UPF0398 family HLLCKODE_00666 435842.HMPREF0848_01557 2.1e-36 158.3 Bacteria gpsB ko:K04074 ko00000,ko03036 Bacteria COG3599@1,COG3599@2 NA|NA|NA D regulation of cell shape HLLCKODE_00667 1046629.Ssal_01940 1.8e-223 781.6 Bacilli rlmL GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016423,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.173,2.1.1.264 ko:K07444,ko:K12297 R07234 RC00003 ko00000,ko01000,ko03009 Bacteria 1TP0X@1239,4HBKY@91061,COG0116@1,COG0116@2 NA|NA|NA L Belongs to the methyltransferase superfamily HLLCKODE_00668 1046629.Ssal_01939 8.1e-269 932.9 Bacilli mapZ ko:K20073 ko00000 Bacteria 1VDPS@1239,2DB6P@1,32TWV@2,4HK8Y@91061 NA|NA|NA D Early cell division protein that marks the future cell division site and supports proper FtsZ ring positioning HLLCKODE_00669 1046629.Ssal_01938 0.0 1986.1 Bacilli snf 2.7.11.1 ko:K08282 ko00000,ko01000 Bacteria 1TPFZ@1239,4HAIF@91061,COG0553@1,COG0553@2 NA|NA|NA L Superfamily II DNA RNA helicases, SNF2 family' HLLCKODE_00670 40041.SZO_03140 4.8e-22 111.7 Streptococcus dysgalactiae group Bacteria 1M9KI@119603,1TXB8@1239,2DJ6Z@1,304WH@2,4I68V@91061 NA|NA|NA HLLCKODE_00671 1046629.Ssal_01936 3.4e-255 887.1 Bacilli mpl GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0016874,GO:0016879,GO:0016881,GO:0042802,GO:0044424,GO:0044464 6.3.2.4,6.3.2.45,6.3.2.8 ko:K01921,ko:K01924,ko:K02558 ko00471,ko00473,ko00550,ko01100,ko01502,map00471,map00473,map00550,map01100,map01502 R01150,R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 iSDY_1059.SDY_4251 Bacteria 1TQ5H@1239,4HAR4@91061,COG0773@1,COG0773@2 NA|NA|NA M Belongs to the MurCDEF family HLLCKODE_00672 1046629.Ssal_01935 5.5e-86 323.6 Bacilli XK27_09675 ko:K07105 ko00000 Bacteria 1VB76@1239,4HM71@91061,COG0454@1,COG0454@2 NA|NA|NA K histone acetyltransferase HPA2 and related acetyltransferases HLLCKODE_00673 1046629.Ssal_01934 1.6e-290 1005.0 Bacilli mltG ko:K07082 ko00000 Bacteria 1TS48@1239,4HAUV@91061,COG1559@1,COG1559@2 NA|NA|NA ADL Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation HLLCKODE_00674 1046629.Ssal_01933 1.2e-77 295.8 Bacilli greA GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 ko:K03624 ko00000,ko03021 Bacteria 1V44S@1239,4HGZU@91061,COG0782@1,COG0782@2 NA|NA|NA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides HLLCKODE_00675 1046629.Ssal_01931 1.4e-162 578.9 Bacilli yidC ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 Bacteria 1TSDN@1239,4HCC8@91061,COG0706@1,COG0706@2 NA|NA|NA U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HLLCKODE_00676 1046629.Ssal_01930 1.1e-43 182.2 Bacilli acyP GO:0003674,GO:0003824,GO:0003998,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016787,GO:0016817,GO:0016818,GO:0050896 3.6.1.7 ko:K01512 ko00620,ko00627,ko01120,map00620,map00627,map01120 R00317,R01421,R01515 RC00043 ko00000,ko00001,ko01000 iSB619.SA_RS07020,iSBO_1134.SBO_2263,iSF_1195.SF0969,iSFxv_1172.SFxv_1053,iS_1188.S1036 Bacteria 1VEM9@1239,4HNN7@91061,COG1254@1,COG1254@2 NA|NA|NA C Belongs to the acylphosphatase family HLLCKODE_00677 1046629.Ssal_01929 8.7e-128 463.0 Bacilli spoU 2.1.1.185 ko:K03218,ko:K03437 ko00000,ko01000,ko03009,ko03016 Bacteria 1V3JP@1239,4HCF5@91061,COG0566@1,COG0566@2 NA|NA|NA J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family HLLCKODE_00678 1046629.Ssal_01928 7.3e-94 349.7 Bacilli XK27_09705 6.1.1.14 ko:K01879,ko:K06950 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1V4QX@1239,4HHW0@91061,COG1418@1,COG1418@2 NA|NA|NA S HD superfamily hydrolase HLLCKODE_00679 1046629.Ssal_01927 5e-101 374.0 Bacilli ybhL GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K06890 ko00000 Bacteria 1V779@1239,4HIX1@91061,COG0670@1,COG0670@2 NA|NA|NA S Belongs to the BI1 family HLLCKODE_00680 1449338.JQLU01000005_gene1830 3.2e-12 79.7 Bacilli ycdA Bacteria 1V92B@1239,2CEN8@1,32ESZ@2,4HJUE@91061 NA|NA|NA S Domain of unknown function (DUF4352) HLLCKODE_00681 1046629.Ssal_01925 4.5e-241 840.1 Bacilli lysA 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPE9@1239,4H9XW@91061,COG0019@1,COG0019@2 NA|NA|NA E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine HLLCKODE_00682 1046629.Ssal_01924 4.5e-89 334.0 Bacteria Bacteria COG1309@1,COG1309@2 NA|NA|NA K transcriptional regulator HLLCKODE_00683 1046629.Ssal_01923 1.6e-36 158.3 Bacilli yneF ko:K09976 ko00000 Bacteria 1VDSU@1239,4HM8G@91061,COG3763@1,COG3763@2 NA|NA|NA S UPF0154 protein HLLCKODE_00684 1046629.Ssal_01922 1.7e-148 531.9 Bacilli murI GO:0000270,GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008657,GO:0008881,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010911,GO:0016020,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0030234,GO:0032780,GO:0034645,GO:0036361,GO:0042030,GO:0042546,GO:0042802,GO:0043086,GO:0043170,GO:0043462,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0047661,GO:0050790,GO:0051336,GO:0051346,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0072586,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:2000371,GO:2000372 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 R00260 RC00302 ko00000,ko00001,ko01000,ko01011 iYO844.BSU28390 Bacteria 1TPPR@1239,4HA46@91061,COG0796@1,COG0796@2 NA|NA|NA M Provides the (R)-glutamate required for cell wall biosynthesis HLLCKODE_00685 1046629.Ssal_01921 9.6e-183 646.0 Bacilli rdgB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66,5.1.1.3 ko:K01776,ko:K02428 ko00230,ko00471,ko01100,map00230,map00471,map01100 R00260,R00426,R00720,R01855,R02100,R02720,R03531 RC00002,RC00302 ko00000,ko00001,ko01000,ko01011 Bacteria 1V6RN@1239,4HCP6@91061,COG0127@1,COG0127@2 NA|NA|NA F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions HLLCKODE_00686 904306.HMPREF9192_0139 5.6e-97 360.1 Bacilli XK27_09740 ko:K07095 ko00000 Bacteria 1VA0U@1239,4HM24@91061,COG0622@1,COG0622@2 NA|NA|NA S Phosphoesterase HLLCKODE_00687 1046629.Ssal_01919 2.7e-85 321.2 Bacilli ykuL Bacteria 1VFAB@1239,4HRWJ@91061,COG0517@1,COG0517@2 NA|NA|NA S CBS domain HLLCKODE_00688 1046629.Ssal_01918 4.1e-128 464.2 Bacilli xerD ko:K04763 ko00000,ko03036 Bacteria 1VY7C@1239,4IT0W@91061,COG4974@1,COG4974@2 NA|NA|NA L tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site HLLCKODE_00689 904306.HMPREF9192_0136 1.7e-120 438.7 Bacilli scpA GO:0003674,GO:0005488,GO:0005515,GO:0042802 ko:K05896 ko00000,ko03036 Bacteria 1V8JV@1239,4IQZ5@91061,COG1354@1,COG1354@2 NA|NA|NA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves HLLCKODE_00690 904306.HMPREF9192_0135 3.4e-95 354.4 Bacilli scpB GO:0003674,GO:0005488,GO:0005515,GO:0042802 ko:K06024 ko00000,ko03036 Bacteria 1V6HI@1239,4HIQ0@91061,COG1386@1,COG1386@2 NA|NA|NA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves HLLCKODE_00691 1046629.Ssal_01915 3.4e-132 477.6 Bacilli rluB GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.19,5.4.99.21,5.4.99.22 ko:K06178,ko:K06182,ko:K06183 ko00000,ko01000,ko03009 Bacteria 1TP68@1239,4H9MU@91061,COG1187@1,COG1187@2 NA|NA|NA J Belongs to the pseudouridine synthase RsuA family HLLCKODE_00692 435842.HMPREF0848_01585 4.4e-39 166.8 Bacilli yidD ko:K08998 ko00000 Bacteria 1VEIG@1239,4HPA3@91061,COG0759@1,COG0759@2 NA|NA|NA S Could be involved in insertion of integral membrane proteins into the membrane HLLCKODE_00693 1046629.Ssal_01912 6e-258 896.3 Bacilli trkH GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005267,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0022803,GO:0022838,GO:0022857,GO:0022890,GO:0030001,GO:0030955,GO:0031224,GO:0031226,GO:0031420,GO:0034220,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046983,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662 ko:K03498,ko:K03499 ko00000,ko02000 2.A.38.1,2.A.38.4 iECDH1ME8569_1439.ECDH1ME8569_1308,iPC815.YPO3762,iSFV_1184.SFV_3651 Bacteria 1TPAF@1239,4HCWN@91061,COG0168@1,COG0168@2 NA|NA|NA P Cation transport protein HLLCKODE_00694 1046629.Ssal_01911 9.3e-245 852.4 Bacilli trkA ko:K03499 ko00000,ko02000 2.A.38.1,2.A.38.4 Bacteria 1TPNS@1239,4HCRM@91061,COG0569@1,COG0569@2 NA|NA|NA P Potassium transporter peripheral membrane component HLLCKODE_00695 1046629.Ssal_01910 5.1e-95 353.6 Bacilli trmL GO:0001510,GO:0002128,GO:0002130,GO:0002131,GO:0002132,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.207 ko:K03216 ko00000,ko01000,ko03016 Bacteria 1V3GW@1239,4HFNY@91061,COG0219@1,COG0219@2 NA|NA|NA J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily HLLCKODE_00696 264199.stu0268 9.6e-87 326.2 Bacilli ribU GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015238,GO:0015711,GO:0015893,GO:0016020,GO:0022857,GO:0032217,GO:0032218,GO:0034220,GO:0035461,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051180,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0090482,GO:0098656 Bacteria 1V4BW@1239,4HHFT@91061,COG3601@1,COG3601@2 NA|NA|NA U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins HLLCKODE_00697 264199.stu0269 2.4e-89 335.1 Bacilli bcrC 3.6.1.27 ko:K19302 ko00550,map00550 R05627 RC00002 ko00000,ko00001,ko01000,ko01011 Bacteria 1VF2U@1239,4HNXR@91061,COG0671@1,COG0671@2 NA|NA|NA I Membrane-associated phospholipid phosphatase HLLCKODE_00698 264199.stu0270 7.1e-156 556.6 Bacteria ko:K20342,ko:K20480 ko02024,map02024 ko00000,ko00001,ko03000 Bacteria COG1396@1,COG1396@2 NA|NA|NA K sequence-specific DNA binding HLLCKODE_00699 1046629.Ssal_01906 0.0 1286.6 Bacilli comA ko:K06147,ko:K06148,ko:K20344 ko02010,ko02024,map02010,map02024 ko00000,ko00001,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.112,3.A.1.21 Bacteria 1V77J@1239,4HAX2@91061,COG2274@1,COG2274@2 NA|NA|NA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain HLLCKODE_00700 1046629.Ssal_01905 3.2e-53 214.2 Bacteria yhaI Bacteria COG3152@1,COG3152@2 NA|NA|NA L Membrane HLLCKODE_00701 1046629.Ssal_01904 1.8e-243 848.2 Firmicutes Bacteria 1VCM1@1239,2E26M@1,32XD2@2 NA|NA|NA S Domain of unknown function (DUF4173) HLLCKODE_00702 1046629.Ssal_01903 6.8e-95 353.2 Bacilli ureI ko:K03191 ko05120,map05120 ko00000,ko00001,ko02000 1.A.29.1.3,1.A.29.1.4,1.A.29.1.5 Bacteria 1UPV2@1239,2DC0F@1,2ZC7C@2,4IVBC@91061 NA|NA|NA S AmiS/UreI family transporter HLLCKODE_00703 264199.stu0281 7.6e-46 189.5 Bacilli ureA GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0019627,GO:0034641,GO:0042221,GO:0043419,GO:0043603,GO:0043605,GO:0044237,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0050896,GO:0051716,GO:0070887,GO:0071241,GO:0071248,GO:0071281,GO:0071704,GO:0071941,GO:1901564,GO:1901565,GO:1901575 3.5.1.5 ko:K01430,ko:K14048 ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120 R00131 RC02798,RC02806 ko00000,ko00001,ko01000 iYO844.BSU36660 Bacteria 1V7GU@1239,4HIJS@91061,COG0831@1,COG0831@2 NA|NA|NA E Belongs to the urease gamma subunit family HLLCKODE_00704 1046629.Ssal_01901 7.8e-54 216.1 Bacilli ureB GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0019627,GO:0034641,GO:0042221,GO:0043419,GO:0043603,GO:0043605,GO:0044237,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0050896,GO:0051716,GO:0070887,GO:0071241,GO:0071248,GO:0071281,GO:0071704,GO:0071941,GO:1901564,GO:1901565,GO:1901575 3.5.1.5 ko:K01429,ko:K14048 ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120 R00131 RC02798,RC02806 ko00000,ko00001,ko01000 Bacteria 1VAIA@1239,4HM0I@91061,COG0832@1,COG0832@2 NA|NA|NA E Belongs to the urease beta subunit family HLLCKODE_00705 904306.HMPREF9192_0116 0.0 1156.0 Bacilli ureC 3.5.1.5 ko:K01428 ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120 R00131 RC02798,RC02806 ko00000,ko00001,ko01000 Bacteria 1TPQP@1239,4HBTS@91061,COG0804@1,COG0804@2 NA|NA|NA E Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family HLLCKODE_00706 1046629.Ssal_01898 6.6e-78 296.6 Bacteria ureE GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 ko:K03187 ko00000 Bacteria COG2371@1,COG2371@2 NA|NA|NA O enzyme active site formation HLLCKODE_00707 264199.stu0285 1.7e-128 465.3 Bacilli ureF ko:K03188 ko00000 Bacteria 1V2H0@1239,4HKQE@91061,COG0830@1,COG0830@2 NA|NA|NA O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter HLLCKODE_00708 1046629.Ssal_01896 9.5e-112 409.5 Bacilli ureG ko:K03189,ko:K04652 ko00000,ko03110 Bacteria 1TS00@1239,4HC5C@91061,COG0378@1,COG0378@2 NA|NA|NA KO Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG HLLCKODE_00709 264199.stu0287 4.1e-158 563.9 Bacilli ureD ko:K03190 ko00000 Bacteria 1TVM2@1239,4HCED@91061,COG0829@1,COG0829@2 NA|NA|NA O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter HLLCKODE_00710 1046629.Ssal_01894 2.1e-177 628.2 Bacilli cbiM GO:0000041,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015675,GO:0016020,GO:0016021,GO:0030001,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 ko:K02007 ko02010,map02010 M00245,M00246 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 Bacteria 1TPEN@1239,4HARY@91061,COG0310@1,COG0310@2 NA|NA|NA P PDGLE domain HLLCKODE_00711 1046629.Ssal_01892 1.4e-136 492.3 Firmicutes ko:K02008 ko02010,map02010 M00245,M00246 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 Bacteria 1V7YC@1239,COG0619@1,COG0619@2 NA|NA|NA P cobalt transport protein HLLCKODE_00712 1046629.Ssal_01891 6.9e-130 469.9 Bacilli cbiO GO:0000041,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015675,GO:0016020,GO:0016021,GO:0030001,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 ko:K02006 ko02010,map02010 M00245,M00246 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 Bacteria 1V16T@1239,4HI15@91061,COG1122@1,COG1122@2 NA|NA|NA P ABC transporter HLLCKODE_00713 1046629.Ssal_01890 1.1e-137 496.1 Bacilli ko:K02030,ko:K16957 ko02010,map02010 M00236,M00585 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.13 Bacteria 1VWFY@1239,4HW2H@91061,COG0834@1,COG0834@2 NA|NA|NA ET ABC transporter substrate-binding protein HLLCKODE_00714 1046629.Ssal_01889 4.1e-164 583.9 Bacilli metQ ko:K02073 ko02010,map02010 M00238 ko00000,ko00001,ko00002,ko02000 3.A.1.24 Bacteria 1TQAS@1239,4HCTA@91061,COG1464@1,COG1464@2 NA|NA|NA M Belongs to the NlpA lipoprotein family HLLCKODE_00715 1046629.Ssal_01888 1.7e-262 911.4 Bacilli dapE 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP2D@1239,4HB9G@91061,COG0624@1,COG0624@2 NA|NA|NA E COG0624, acetylornithine deacetylase succinyl-diaminopimelate desuccinylase and related deacylases HLLCKODE_00716 1046629.Ssal_01887 2e-186 658.3 Bacilli metN ko:K02071 ko02010,map02010 M00238 ko00000,ko00001,ko00002,ko02000 3.A.1.24 Bacteria 1TPPN@1239,4H9VX@91061,COG1135@1,COG1135@2 NA|NA|NA P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system HLLCKODE_00717 1046629.Ssal_01886 1.2e-99 369.4 Bacilli metI ko:K02072 ko02010,map02010 M00238 ko00000,ko00001,ko00002,ko02000 3.A.1.24 Bacteria 1V0GE@1239,4HFMB@91061,COG2011@1,COG2011@2 NA|NA|NA P ABC transporter (Permease HLLCKODE_00718 1046629.Ssal_01885 5.7e-209 733.4 Bacilli sstT GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005295,GO:0005310,GO:0005342,GO:0005343,GO:0005416,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006835,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015077,GO:0015081,GO:0015171,GO:0015175,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015672,GO:0015711,GO:0015804,GO:0015849,GO:0016020,GO:0016021,GO:0017153,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0032329,GO:0034220,GO:0035725,GO:0044425,GO:0044464,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1903825,GO:1905039 ko:K07862 ko00000,ko02000 2.A.23.4 iAF1260.b3089,iBWG_1329.BWG_2799,iECDH10B_1368.ECDH10B_3265,iECDH1ME8569_1439.ECDH1ME8569_2984,iECH74115_1262.ECH74115_4404,iECIAI1_1343.ECIAI1_3235,iECO103_1326.ECO103_3834,iECO111_1330.ECO111_3911,iECO26_1355.ECO26_4192,iECP_1309.ECP_3180,iECSE_1348.ECSE_3370,iECSP_1301.ECSP_4063,iECUMN_1333.ECUMN_3573,iECW_1372.ECW_m3356,iECs_1301.ECs3971,iEKO11_1354.EKO11_0630,iETEC_1333.ETEC_3359,iEcDH1_1363.EcDH1_0612,iEcE24377_1341.EcE24377A_3557,iG2583_1286.G2583_3813,iJO1366.b3089,iJR904.b3089,iSFV_1184.SFV_3130,iSSON_1240.SSON_3242,iUMNK88_1353.UMNK88_3845,iWFL_1372.ECW_m3356,iY75_1357.Y75_RS16050,iYL1228.KPN_03517,iZ_1308.Z4442 Bacteria 1TPD2@1239,4HBEC@91061,COG3633@1,COG3633@2 NA|NA|NA E Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) HLLCKODE_00719 322159.STER_0345 7.1e-158 563.1 Bacilli salL GO:0003674,GO:0003824,GO:0016740,GO:0016765 2.5.1.63,2.5.1.94 ko:K09134,ko:K21153,ko:K22205 ko00000,ko01000 Bacteria 1TSR3@1239,4HAW6@91061,COG1912@1,COG1912@2 NA|NA|NA S S-adenosyl-l-methionine hydroxide adenosyltransferase HLLCKODE_00720 1046629.Ssal_01883 6.7e-93 346.7 Bacilli ko:K16924,ko:K16927 M00582 ko00000,ko00002,ko02000 3.A.1.29,3.A.1.32 Bacteria 1V1GT@1239,4HGAE@91061,COG4720@1,COG4720@2 NA|NA|NA S UPF0397 protein HLLCKODE_00721 1046629.Ssal_01882 2.9e-304 1050.4 Bacilli ykoD GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0008150,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085 ko:K02006,ko:K16786,ko:K16787 ko02010,map02010 M00245,M00246,M00582 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.18,3.A.1.22,3.A.1.23,3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 Bacteria 1TPH8@1239,4HAJM@91061,COG1122@1,COG1122@2 NA|NA|NA P abc transporter atp-binding protein HLLCKODE_00722 1046629.Ssal_01881 7.2e-147 526.6 Bacilli cbiQ ko:K16785,ko:K16786,ko:K16787 ko02010,map02010 M00582 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 iSB619.SA_RS14165 Bacteria 1TPMV@1239,4HBTW@91061,COG0619@1,COG0619@2 NA|NA|NA P cobalt transport HLLCKODE_00723 1046629.Ssal_01880 1.8e-116 425.2 Bacilli ktrA ko:K03499 ko00000,ko02000 2.A.38.1,2.A.38.4 Bacteria 1TQ9H@1239,4HBPH@91061,COG0569@1,COG0569@2 NA|NA|NA P COG0569 K transport systems, NAD-binding component HLLCKODE_00724 1046629.Ssal_01879 6.4e-233 813.1 Bacilli ko:K03498 ko00000,ko02000 2.A.38.1,2.A.38.4 Bacteria 1TQ4S@1239,4H9ME@91061,COG0168@1,COG0168@2 NA|NA|NA P COG0168 Trk-type K transport systems, membrane components HLLCKODE_00725 1046629.Ssal_01878 2.7e-126 458.0 Bacilli rsmG GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 ko:K03501 ko00000,ko01000,ko03009,ko03036 Bacteria 1TPBT@1239,4HAAZ@91061,COG0357@1,COG0357@2 NA|NA|NA J Ribosomal RNA small subunit methyltransferase G HLLCKODE_00726 1046629.Ssal_01877 2e-89 335.1 Bacilli yceD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 ko:K07040 ko00000 Bacteria 1VB08@1239,4HME9@91061,COG1399@1,COG1399@2 NA|NA|NA K metal-binding, possibly nucleic acid-binding protein HLLCKODE_00727 435842.HMPREF0848_01620 7.9e-123 446.4 Bacilli Bacteria 1TS81@1239,4H9NE@91061,COG0745@1,COG0745@2 NA|NA|NA T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain HLLCKODE_00728 1046629.Ssal_01875 2.5e-278 964.1 Bacilli Bacteria 1UHQC@1239,4HWKS@91061,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor HLLCKODE_00729 1046629.Ssal_01874 3e-81 307.8 Bacilli nrdR GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K07738 ko00000,ko03000 Bacteria 1V3JA@1239,4HGXA@91061,COG1327@1,COG1327@2 NA|NA|NA K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes HLLCKODE_00730 1046629.Ssal_01873 2.4e-212 744.6 Bacteria dnaB ko:K03346 ko00000,ko03032 Bacteria COG3611@1,COG3611@2 NA|NA|NA L Replication initiation and membrane attachment HLLCKODE_00731 1046629.Ssal_01872 1.3e-165 589.0 Bacilli dnaI GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 ko:K11144 ko00000,ko03032 Bacteria 1TPZX@1239,4HABS@91061,COG1484@1,COG1484@2 NA|NA|NA L Primosomal protein DnaI HLLCKODE_00732 1046629.Ssal_01871 2.6e-247 860.9 Bacilli der GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 1.1.1.399,1.1.1.95 ko:K00058,ko:K03977 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko03009,ko04147 Bacteria 1TPNM@1239,4HAJ6@91061,COG1160@1,COG1160@2 NA|NA|NA S GTPase that plays an essential role in the late steps of ribosome biogenesis HLLCKODE_00733 1046629.Ssal_01870 2.8e-103 381.3 Bacilli Bacteria 1VC9V@1239,2CH4S@1,32S58@2,4HNHW@91061 NA|NA|NA HLLCKODE_00734 1046629.Ssal_01869 1.5e-228 798.5 Bacilli serS GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004828,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006434,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0010467,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iAF987.Gmet_3528,iSDY_1059.SDY_2368 Bacteria 1TP4W@1239,4H9Y4@91061,COG0172@1,COG0172@2 NA|NA|NA J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) HLLCKODE_00735 904306.HMPREF9192_0083 2.5e-62 244.6 Bacilli manO Bacteria 1VF36@1239,4HPYI@91061,COG4687@1,COG4687@2 NA|NA|NA S protein conserved in bacteria HLLCKODE_00736 904306.HMPREF9192_0082 4e-167 594.0 Bacilli manN ko:K02796 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 M00276 R02630 RC00017,RC03206 ko00000,ko00001,ko00002,ko02000 4.A.6.1 Bacteria 1TQA3@1239,4HA3K@91061,COG3716@1,COG3716@2 NA|NA|NA G PTS system mannose fructose sorbose family IID component HLLCKODE_00737 904306.HMPREF9192_0081 1.2e-114 419.5 Bacilli manM ko:K02795,ko:K02796 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 M00276 R02630 RC00017,RC03206 ko00000,ko00001,ko00002,ko02000 4.A.6.1 Bacteria 1TPKK@1239,4H9QI@91061,COG3715@1,COG3715@2 NA|NA|NA G pts system HLLCKODE_00738 1046629.Ssal_01865 4.9e-174 617.1 Bacilli manL 2.7.1.191 ko:K02793,ko:K02794 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 M00276 R02630 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.6.1 Bacteria 1TQJ4@1239,4H9Z8@91061,COG2893@1,COG2893@2,COG3444@1,COG3444@2 NA|NA|NA G pts system HLLCKODE_00739 1046629.Ssal_01864 2.2e-66 258.1 Firmicutes manO Bacteria 1V6KV@1239,COG4687@1,COG4687@2 NA|NA|NA S Protein conserved in bacteria HLLCKODE_00740 1046629.Ssal_01863 1.4e-159 568.9 Bacilli manN ko:K02796 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 M00276 R02630 RC00017,RC03206 ko00000,ko00001,ko00002,ko02000 4.A.6.1 Bacteria 1TQA3@1239,4HA3K@91061,COG3716@1,COG3716@2 NA|NA|NA G PTS system mannose fructose sorbose family IID component HLLCKODE_00741 435842.HMPREF0848_01634 4.8e-132 477.2 Bacilli manY ko:K02795,ko:K02796 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 M00276 R02630 RC00017,RC03206 ko00000,ko00001,ko00002,ko02000 4.A.6.1 Bacteria 1TPKK@1239,4H9QI@91061,COG3715@1,COG3715@2 NA|NA|NA G pts system HLLCKODE_00742 1046629.Ssal_01861 3.1e-168 597.8 Bacilli manL 2.7.1.191 ko:K02793,ko:K02794 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 M00276 R02630 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.6.1 Bacteria 1TQJ4@1239,4H9Z8@91061,COG2893@1,COG2893@2,COG3444@1,COG3444@2 NA|NA|NA G pts system HLLCKODE_00743 264199.stu0334 1.2e-137 495.7 Bacilli XK27_00940 1.2.1.70,3.5.1.9 ko:K02492,ko:K07130 ko00380,ko00630,ko00860,ko01100,ko01110,ko01120,map00380,map00630,map00860,map01100,map01110,map01120 M00038,M00121 R00988,R01959,R04109,R04911 RC00055,RC00149,RC00263,RC00323 ko00000,ko00001,ko00002,ko01000 Bacteria 1TRBQ@1239,4HCAB@91061,COG1878@1,COG1878@2 NA|NA|NA S Metal-dependent hydrolase HLLCKODE_00744 1046629.Ssal_01859 3.5e-154 550.8 Bacilli yitU 3.1.3.104 ko:K21064 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R07280 RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 1TREF@1239,4H9Y9@91061,COG0561@1,COG0561@2 NA|NA|NA S hydrolases of the HAD superfamily HLLCKODE_00745 1046629.Ssal_01858 1.6e-247 861.7 Bacilli pbuO ko:K06901 ko00000,ko02000 2.A.1.40 Bacteria 1TQC6@1239,4HANG@91061,COG2252@1,COG2252@2 NA|NA|NA S permease HLLCKODE_00746 264199.stu0337 2.7e-76 291.2 Bacilli ydiB GO:0002949,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.7.1.221,5.1.1.1 ko:K01775,ko:K06925,ko:K07102 ko00473,ko00520,ko01100,ko01502,map00473,map00520,map01100,map01502 R00401,R08968,R11024 RC00002,RC00078,RC00285 ko00000,ko00001,ko01000,ko01011,ko03016 Bacteria 1V6CV@1239,4HIIF@91061,COG0802@1,COG0802@2 NA|NA|NA M ATPase or kinase HLLCKODE_00747 1046629.Ssal_01856 5.3e-87 327.0 Bacteria XK27_05885 2.3.1.82 ko:K18816 br01600,ko00000,ko01000,ko01504 Bacteria COG1247@1,COG1247@2 NA|NA|NA M phosphinothricin N-acetyltransferase activity HLLCKODE_00748 1046629.Ssal_01855 5.5e-191 673.7 Bacilli brpA Bacteria 1TR1B@1239,4HA09@91061,COG1316@1,COG1316@2 NA|NA|NA K Transcriptional HLLCKODE_00749 1046629.Ssal_01854 2.3e-81 308.1 Bacilli rimP GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576 ko:K09748 ko00000,ko03009 Bacteria 1V6KT@1239,4HH88@91061,COG0779@1,COG0779@2 NA|NA|NA S Required for maturation of 30S ribosomal subunits HLLCKODE_00750 1046629.Ssal_01853 2.4e-196 691.4 Bacilli nusA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 ko:K02600,ko:K02945 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03009,ko03011,ko03021 Bacteria 1TPB3@1239,4HA7F@91061,COG0195@1,COG0195@2 NA|NA|NA K Participates in both transcription termination and antitermination HLLCKODE_00751 904306.HMPREF9192_0067 4e-47 193.7 Bacilli ylxR ko:K02600,ko:K07742 ko00000,ko03009,ko03021 Bacteria 1VEJS@1239,4HKBY@91061,COG2740@1,COG2740@2 NA|NA|NA K Nucleic-acid-binding protein implicated in transcription termination HLLCKODE_00752 1046629.Ssal_01850 8e-42 176.0 Firmicutes ylxQ ko:K07590,ko:K07742 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1VEYG@1239,COG1358@1,COG1358@2 NA|NA|NA J ribosomal protein HLLCKODE_00753 435842.HMPREF0848_01646 0.0 1146.3 Bacilli infB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 ko:K02519 ko00000,ko03012,ko03029 Bacteria 1TPAI@1239,4HA8S@91061,COG0532@1,COG0532@2 NA|NA|NA J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex HLLCKODE_00754 1046629.Ssal_01846 8.6e-57 226.1 Bacilli rbfA GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030490,GO:0033554,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071840,GO:0090304,GO:1901360 ko:K02834 ko00000,ko03009 Bacteria 1VA0P@1239,4HII1@91061,COG0858@1,COG0858@2 NA|NA|NA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA HLLCKODE_00755 1046629.Ssal_01845 5.5e-98 363.6 Bacilli yvdD 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 Bacteria 1UKED@1239,4HGSU@91061,COG1611@1,COG1611@2 NA|NA|NA S Belongs to the LOG family HLLCKODE_00756 435842.HMPREF0848_01649 5.1e-189 667.2 Bacilli femA 2.3.2.16,2.3.2.17,2.3.2.18 ko:K11693,ko:K11694,ko:K11695,ko:K12554 ko00550,ko01100,map00550,map01100 R08776,R08777,R08778,R08780 RC00055,RC00064,RC00096 ko00000,ko00001,ko01000,ko01011 Bacteria 1UZIJ@1239,4HAQ3@91061,COG2348@1,COG2348@2 NA|NA|NA V protein involved in methicillin resistance HLLCKODE_00757 1046629.Ssal_01844 4.2e-267 926.8 Bacilli murE 6.3.2.13,6.3.2.7 ko:K01928,ko:K05362 ko00300,ko00550,ko01100,map00300,map00550,map01100 R02786,R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 Bacteria 1TPQE@1239,4H9T1@91061,COG0769@1,COG0769@2 NA|NA|NA M to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan HLLCKODE_00758 1046629.Ssal_01843 8.3e-277 959.1 Bacilli ytgP GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03328,ko:K06409 ko00000,ko02000 2.A.66.2,2.A.66.2.14 Bacteria 1TNYX@1239,4H9RY@91061,COG2244@1,COG2244@2 NA|NA|NA S Membrane protein involved in the export of O-antigen and teichoic acid HLLCKODE_00759 1046629.Ssal_01842 0.0 1761.9 Bacilli pacL 3.6.3.8,3.6.3.9 ko:K01537,ko:K01539 ko04022,ko04024,ko04260,ko04261,ko04911,ko04918,ko04919,ko04925,ko04960,ko04961,ko04964,ko04970,ko04971,ko04972,ko04973,ko04974,ko04976,ko04978,map04022,map04024,map04260,map04261,map04911,map04918,map04919,map04925,map04960,map04961,map04964,map04970,map04971,map04972,map04973,map04974,map04976,map04978 ko00000,ko00001,ko01000,ko04147 3.A.3.1,3.A.3.2 Bacteria 1TPF5@1239,4HTQ4@91061,COG0474@1,COG0474@2 NA|NA|NA P cation transport ATPase HLLCKODE_00760 1046629.Ssal_01840 2.6e-200 704.5 Bacilli metB GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0016740,GO:0016765,GO:0016829,GO:0016846 2.5.1.48,4.4.1.8 ko:K01739,ko:K01760 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04941,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00382,RC00420,RC00488,RC00710,RC01245,RC02303,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPC7@1239,4HAFQ@91061,COG0626@1,COG0626@2 NA|NA|NA E cystathionine HLLCKODE_00761 1046629.Ssal_01839 5.6e-222 776.5 Bacilli malY 4.4.1.8 ko:K14155 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko01000,ko01007 Bacteria 1TP5G@1239,4H9PE@91061,COG1168@1,COG1168@2 NA|NA|NA E COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities HLLCKODE_00762 1046629.Ssal_01523 2.6e-264 917.5 Bacilli Bacteria 1TPFS@1239,4H9V9@91061,COG3039@1,COG3039@2 NA|NA|NA L Transposase HLLCKODE_00763 1046629.Ssal_01838 3e-304 1050.4 Bacteria 3.2.1.26,3.2.1.65 ko:K01193,ko:K01212 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00801,R00802,R02410,R03635,R03921,R05624,R06088,R11311 RC00028,RC00077,RC03278 ko00000,ko00001,ko01000 GH32 Bacteria COG1621@1,COG1621@2 NA|NA|NA G Belongs to the glycosyl hydrolase 32 family HLLCKODE_00764 1046629.Ssal_01837 0.0 1177.5 Bacilli sacB GO:0005575,GO:0005576 2.4.1.10,2.4.1.9,3.2.1.26 ko:K00692,ko:K01193,ko:K20811 ko00052,ko00500,ko01100,ko02020,map00052,map00500,map01100,map02020 R00801,R00802,R02410,R03635,R03921,R04194,R05140,R06088 RC00028,RC00077,RC00247 ko00000,ko00001,ko01000,ko01003 GH32,GH68 Bacteria 1TR8C@1239,4HBYU@91061,COG1621@1,COG1621@2 NA|NA|NA G Belongs to the glycosyl hydrolase 68 family HLLCKODE_00765 1046629.Ssal_01836 5.7e-112 410.2 Bacilli upp GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.9 ko:K00761 ko00240,ko01100,map00240,map01100 R00966 RC00063 ko00000,ko00001,ko01000 iSB619.SA_RS11010 Bacteria 1TPMT@1239,4H9Y0@91061,COG0035@1,COG0035@2 NA|NA|NA F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate HLLCKODE_00766 1046629.Ssal_01835 3.7e-105 387.5 Bacilli clpP GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0006355,GO:0006508,GO:0006515,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019538,GO:0030163,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042623,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051603,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 ko00000,ko00001,ko01000,ko01002 Bacteria 1TQ91@1239,4HA8J@91061,COG0740@1,COG0740@2 NA|NA|NA OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins HLLCKODE_00767 1046629.Ssal_01834 6.4e-73 280.0 Bacilli ylbF Bacteria 1V3R6@1239,4HGYS@91061,COG3679@1,COG3679@2 NA|NA|NA S Belongs to the UPF0342 family HLLCKODE_00768 1046629.Ssal_01833 7.1e-46 189.5 Bacilli ylbG Bacteria 1VF52@1239,4HNTH@91061,COG4471@1,COG4471@2 NA|NA|NA S UPF0298 protein HLLCKODE_00769 1046629.Ssal_01832 2.6e-211 741.1 Bacilli livJ ko:K01999 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 1TPQ2@1239,4H9PI@91061,COG0683@1,COG0683@2 NA|NA|NA E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component HLLCKODE_00770 1046629.Ssal_01831 4.2e-145 520.8 Bacilli livH ko:K01997 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 1TR24@1239,4HBFZ@91061,COG0559@1,COG0559@2 NA|NA|NA E Belongs to the binding-protein-dependent transport system permease family HLLCKODE_00771 1046629.Ssal_01830 4.9e-139 500.7 Bacilli livM ko:K01995,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 1TPMZ@1239,4HDIU@91061,COG4177@1,COG4177@2 NA|NA|NA E Belongs to the binding-protein-dependent transport system permease family HLLCKODE_00772 1046629.Ssal_01829 4e-136 490.7 Bacilli livG ko:K01995,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 1TR0P@1239,4HASG@91061,COG0411@1,COG0411@2 NA|NA|NA E COG0411 ABC-type branched-chain amino acid transport systems, ATPase component HLLCKODE_00773 1046629.Ssal_01828 5.6e-124 450.3 Bacilli livF ko:K01996 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 1TPW4@1239,4HABJ@91061,COG0410@1,COG0410@2 NA|NA|NA E COG0410 ABC-type branched-chain amino acid transport systems, ATPase component HLLCKODE_00774 1046629.Ssal_01826 6.6e-111 406.8 Bacilli acuB ko:K04767 ko00000 Bacteria 1V4CD@1239,4HGX4@91061,COG0517@1,COG0517@2 NA|NA|NA S CBS domain HLLCKODE_00775 1046629.Ssal_01825 6.3e-168 596.7 Bacilli cysK GO:0000096,GO:0000097,GO:0000098,GO:0003674,GO:0003824,GO:0004122,GO:0004124,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006555,GO:0006563,GO:0006790,GO:0006807,GO:0008134,GO:0008144,GO:0008150,GO:0008152,GO:0008284,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009070,GO:0009087,GO:0009987,GO:0016043,GO:0016053,GO:0016054,GO:0016740,GO:0016765,GO:0016829,GO:0016835,GO:0016836,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0022607,GO:0030170,GO:0032991,GO:0032993,GO:0036094,GO:0042127,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043388,GO:0043436,GO:0043933,GO:0044085,GO:0044093,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046395,GO:0046983,GO:0048037,GO:0048518,GO:0048522,GO:0050662,GO:0050789,GO:0050794,GO:0051098,GO:0051099,GO:0051101,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051291,GO:0065003,GO:0065007,GO:0065009,GO:0070279,GO:0071704,GO:0071840,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1904796,GO:1904798,GO:2000677,GO:2000679 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP30@1239,4HAMU@91061,COG0031@1,COG0031@2 NA|NA|NA E Belongs to the cysteine synthase cystathionine beta- synthase family HLLCKODE_00776 1046629.Ssal_01824 2.2e-108 398.3 Bacilli yvyE 3.4.13.9 ko:K01271 ko00000,ko01000,ko01002 Bacteria 1V6MQ@1239,4HBIT@91061,COG1739@1,COG1739@2 NA|NA|NA S YigZ family HLLCKODE_00777 1046629.Ssal_01823 2.4e-237 827.8 Bacilli comFA GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 ko:K02240 M00429 ko00000,ko00002,ko02044 3.A.11.1 Bacteria 1TPZE@1239,4HB00@91061,COG4098@1,COG4098@2 NA|NA|NA L Superfamily II DNA RNA helicase required for DNA uptake (late competence protein) HLLCKODE_00778 904306.HMPREF9192_0040 7.6e-99 366.7 Bacteria comFC ko:K02242 M00429 ko00000,ko00002,ko02044 Bacteria COG1040@1,COG1040@2 NA|NA|NA K competence protein HLLCKODE_00779 1046629.Ssal_01821 1.6e-94 352.1 Bacilli hpf GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113 ko:K05808 ko00000,ko03009 Bacteria 1V1D5@1239,4HFX9@91061,COG1544@1,COG1544@2 NA|NA|NA J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase HLLCKODE_00780 1046629.Ssal_01811 8.2e-257 892.5 Bacilli lysC GO:0000166,GO:0003674,GO:0003824,GO:0004072,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017076,GO:0019202,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 iYO844.BSU03790 Bacteria 1TPQJ@1239,4HAEP@91061,COG0527@1,COG0527@2 NA|NA|NA E Belongs to the aspartokinase family HLLCKODE_00781 1046629.Ssal_01810 3.5e-117 427.6 Bacilli Bacteria 1VA1U@1239,4HMKX@91061,COG0637@1,COG0637@2 NA|NA|NA S HAD hydrolase, family IA, variant 3 HLLCKODE_00782 1046629.Ssal_01809 6.2e-140 503.4 Bacilli phaB GO:0003674,GO:0003824,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006635,GO:0006636,GO:0008150,GO:0008152,GO:0008610,GO:0009056,GO:0009058,GO:0009062,GO:0009987,GO:0016042,GO:0016053,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016860,GO:0016863,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033559,GO:0034017,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:0072330,GO:1901575,GO:1901576 5.3.3.14,5.3.3.18 ko:K15866,ko:K18474 ko00061,ko00360,ko01120,map00061,map00360,map01120 R07639,R09837,R09839 RC00004,RC00326,RC01078,RC02689,RC03003 ko00000,ko00001,ko01000,ko01004 Bacteria 1TQ2V@1239,4HBT0@91061,COG1024@1,COG1024@2 NA|NA|NA I Belongs to the enoyl-CoA hydratase isomerase family HLLCKODE_00783 1046629.Ssal_01808 5.2e-72 276.9 Bacilli marR Bacteria 1V6GY@1239,4HIMR@91061,COG1846@1,COG1846@2 NA|NA|NA K Transcriptional regulator, MarR family HLLCKODE_00784 1046629.Ssal_01807 3.2e-170 604.4 Bacilli fabH 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 1TP0K@1239,4HATK@91061,COG0332@1,COG0332@2 NA|NA|NA I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids HLLCKODE_00785 1046629.Ssal_01806 3.3e-30 137.1 Bacilli acpP GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 ko:K02078 ko00000,ko00001 Bacteria 1VGIY@1239,4HP0V@91061,COG0236@1,COG0236@2 NA|NA|NA IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis HLLCKODE_00786 1046629.Ssal_01805 1.2e-172 612.5 Bacilli fabK 1.3.1.9 ko:K02371 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000,ko01004 iHN637.CLJU_RS20775 Bacteria 1TPC3@1239,4H9T0@91061,COG2070@1,COG2070@2 NA|NA|NA S 2-Nitropropane dioxygenase HLLCKODE_00787 1046629.Ssal_01804 7.2e-164 583.2 Bacilli fabD 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 1TPB7@1239,4HBCU@91061,COG0331@1,COG0331@2 NA|NA|NA I Malonyl CoA-acyl carrier protein transacylase HLLCKODE_00788 904306.HMPREF9192_0291 6.2e-126 456.8 Bacilli Bacteria 1TP76@1239,4HAA6@91061,COG1028@1,COG1028@2 NA|NA|NA IQ reductase HLLCKODE_00789 1046629.Ssal_01802 5.7e-233 813.1 Bacilli fabF 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 1TPA7@1239,4H9SD@91061,COG0304@1,COG0304@2 NA|NA|NA I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP HLLCKODE_00790 904306.HMPREF9192_0293 2.5e-54 218.4 Bacilli accB 2.3.1.12,4.1.1.3 ko:K00627,ko:K01571,ko:K02160 ko00010,ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00010,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00307,M00376 R00209,R00217,R00742,R02569 RC00004,RC00040,RC00367,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000,ko02000 3.B.1.1.1 Bacteria 1VAB7@1239,4HKCS@91061,COG0511@1,COG0511@2 NA|NA|NA I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA HLLCKODE_00791 1046629.Ssal_01800 1.5e-71 275.4 Bacilli fabZ 3.5.1.108,4.2.1.59 ko:K02372,ko:K16363 ko00061,ko00540,ko00780,ko01100,ko01212,map00061,map00540,map00780,map01100,map01212 M00060,M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965,R07764,R10117,R10121 RC00166,RC00300,RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004,ko01005 Bacteria 1V6EX@1239,4HGX1@91061,COG0764@1,COG0764@2 NA|NA|NA I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs HLLCKODE_00792 1046629.Ssal_01798 8.3e-257 892.5 Bacilli accC GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 iSF_1195.SF3294 Bacteria 1TP16@1239,4HARK@91061,COG0439@1,COG0439@2 NA|NA|NA I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism HLLCKODE_00793 1046629.Ssal_01797 3e-159 567.8 Bacilli accD 2.1.3.15,6.4.1.2 ko:K01962,ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP4U@1239,4HAI7@91061,COG0777@1,COG0777@2 NA|NA|NA I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA HLLCKODE_00794 1046629.Ssal_01796 5.1e-139 500.4 Bacilli accA 2.1.3.15,6.4.1.2 ko:K01962,ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 Bacteria 1UHNS@1239,4HA4C@91061,COG0825@1,COG0825@2 NA|NA|NA I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA HLLCKODE_00795 1046629.Ssal_01795 4.7e-90 337.0 Bacilli luxS GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0007154,GO:0007267,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009116,GO:0009119,GO:0009372,GO:0009987,GO:0010699,GO:0016053,GO:0016829,GO:0016846,GO:0017144,GO:0019284,GO:0019752,GO:0023052,GO:0033353,GO:0034641,GO:0042278,GO:0043094,GO:0043102,GO:0043436,GO:0043768,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0046128,GO:0046394,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0051704,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901657 4.4.1.21 ko:K07173 ko00270,ko01100,ko01230,ko02024,ko02026,ko05111,map00270,map01100,map01230,map02024,map02026,map05111 M00609 R01291 RC00069,RC01929 ko00000,ko00001,ko00002,ko01000 iECIAI39_1322.ECIAI39_2877,iPC815.YPO3300 Bacteria 1V1V3@1239,4HFR0@91061,COG1854@1,COG1854@2 NA|NA|NA H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) HLLCKODE_00796 904306.HMPREF9192_0315 2.4e-207 728.4 Bacilli rny GO:0003674,GO:0005488,GO:0005515,GO:0042802 ko:K05802,ko:K18682 ko03018,map03018 ko00000,ko00001,ko01000,ko02000,ko03019 1.A.23.1.1 Bacteria 1TP48@1239,4HC9J@91061,COG1418@1,COG1418@2,COG4372@1,COG4372@2 NA|NA|NA D Endoribonuclease that initiates mRNA decay HLLCKODE_00797 1046629.Ssal_01793 6.8e-112 410.2 Bacilli fruR ko:K03436 ko00000,ko03000 Bacteria 1TSF8@1239,4HDT9@91061,COG1349@1,COG1349@2 NA|NA|NA K transcriptional HLLCKODE_00798 1046629.Ssal_01792 7.6e-166 589.7 Bacilli pfkB 2.7.1.11,2.7.1.56 ko:K00882,ko:K16370 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00345 R00756,R02071,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQ36@1239,4HANU@91061,COG1105@1,COG1105@2 NA|NA|NA H Belongs to the carbohydrate kinase PfkB family. LacC subfamily HLLCKODE_00799 1046629.Ssal_01791 0.0 1161.0 Bacilli fruA 2.7.1.202 ko:K02768,ko:K02769,ko:K02770,ko:K02806 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 Bacteria 1TPKU@1239,4H9KR@91061,COG1299@1,COG1299@2,COG1445@1,COG1445@2,COG1762@1,COG1762@2 NA|NA|NA G phosphotransferase system HLLCKODE_00800 435842.HMPREF0848_00027 9e-256 889.0 Bacilli gor GO:0000166,GO:0003674,GO:0003824,GO:0004362,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015036,GO:0015037,GO:0015038,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071949,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.7 ko:K00383 ko00480,ko04918,map00480,map04918 R00094,R00115 RC00011 ko00000,ko00001,ko01000 iZ_1308.Z4900 Bacteria 1TQFH@1239,4HCT8@91061,COG1249@1,COG1249@2 NA|NA|NA C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family HLLCKODE_00801 1046629.Ssal_01788 1.2e-225 788.9 Bacilli folC 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0166 Bacteria 1TPX5@1239,4HBJM@91061,COG0285@1,COG0285@2 NA|NA|NA H Belongs to the folylpolyglutamate synthase family HLLCKODE_00803 1046629.Ssal_01786 2e-208 731.5 Bacilli iscS2 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 Bacteria 1TP21@1239,4HAEE@91061,COG1104@1,COG1104@2 NA|NA|NA E Cysteine sulfinate desulfinase cysteine desulfurase and related enzymes HLLCKODE_00804 904306.HMPREF9192_0323 1.7e-224 785.0 Bacilli thiI GO:0000049,GO:0002937,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017144,GO:0018130,GO:0019438,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042364,GO:0042723,GO:0042724,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.8.1.4 ko:K03151 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07461 ko00000,ko00001,ko01000,ko03016 iECNA114_1301.ECNA114_0400,iECO26_1355.ECO26_0455,iECSF_1327.ECSF_0383,iSDY_1059.SDY_0307 Bacteria 1TPNW@1239,4HAV9@91061,COG0301@1,COG0301@2 NA|NA|NA H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS HLLCKODE_00805 1046629.Ssal_01782 6.9e-289 999.2 Bacilli gtf1 2.4.1.52 ko:K00712 ko00000,ko01000,ko01003 GT4 Bacteria 1TR6K@1239,4HGDG@91061,COG0438@1,COG0438@2 NA|NA|NA M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon HLLCKODE_00806 904306.HMPREF9192_0325 4.1e-253 880.2 Firmicutes gtf2 Bacteria 1TQZR@1239,COG0438@1,COG0438@2 NA|NA|NA M A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1 HLLCKODE_00807 904306.HMPREF9192_0326 9e-82 309.7 Bacteria 2.3.1.128 ko:K03789 ko00000,ko01000,ko03009 Bacteria COG0454@1,COG0456@2 NA|NA|NA K acetyltransferase HLLCKODE_00808 264199.stu0417 4.5e-49 200.3 Bacilli rplU GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02888 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V9YH@1239,4HIGK@91061,COG0261@1,COG0261@2 NA|NA|NA J This protein binds to 23S rRNA in the presence of protein L20 HLLCKODE_00809 1046629.Ssal_01778 1.5e-46 191.8 Bacilli rpmA GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904 ko:K02899 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V6HW@1239,4HIMN@91061,COG0211@1,COG0211@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL27 family HLLCKODE_00810 322159.STER_0457 1.1e-132 479.2 Bacteria ydaF_2 Bacteria COG1670@1,COG1670@2 NA|NA|NA J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins HLLCKODE_00811 1046629.Ssal_01776 5e-63 246.9 Bacilli WQ51_03320 Bacteria 1VHA6@1239,4HPTC@91061,COG4835@1,COG4835@2 NA|NA|NA S cog cog4835 HLLCKODE_00812 1046629.Ssal_01775 1.6e-146 525.4 Bacilli XK27_08360 Bacteria 1TRM7@1239,4HVKJ@91061,COG1307@1,COG1307@2 NA|NA|NA S EDD domain protein, DegV family HLLCKODE_00813 1046629.Ssal_01774 2.5e-138 498.0 Bacilli dapB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0070402,GO:0070404,GO:0071704,GO:0071944,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 iJN678.dapB,iNJ661.Rv2773c,iYO844.BSU22490 Bacteria 1TR9D@1239,4HA5X@91061,COG0289@1,COG0289@2 NA|NA|NA E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate HLLCKODE_00814 904306.HMPREF9192_0334 9.3e-220 769.2 Bacilli cca 2.7.7.19,2.7.7.72 ko:K00970,ko:K00974 ko03013,ko03018,map03013,map03018 R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016,ko03019 Bacteria 1TQ2A@1239,4HB2W@91061,COG0617@1,COG0617@2 NA|NA|NA J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HLLCKODE_00815 1046629.Ssal_01772 0.0 1188.7 Bacilli yfmR ko:K15738 ko00000,ko02000 3.A.1.120.6 Bacteria 1TPAX@1239,4H9TK@91061,COG0488@1,COG0488@2 NA|NA|NA S abc transporter atp-binding protein HLLCKODE_00816 1123298.KB904062_gene886 1.7e-26 125.9 Bacteria Bacteria COG3247@1,COG3247@2 NA|NA|NA U response to pH HLLCKODE_00817 904306.HMPREF9192_0338 3.7e-129 467.6 Bacilli 3.6.1.13,3.6.1.55 ko:K01515,ko:K03574 ko00230,map00230 R01054 RC00002 ko00000,ko00001,ko01000,ko03400 Bacteria 1TST7@1239,4HEFP@91061,COG1051@1,COG1051@2 NA|NA|NA F AdP-ribose pyrophosphatase HLLCKODE_00818 1046629.Ssal_01769 1.8e-209 734.9 Bacilli nadD 2.7.1.22,2.7.7.1,2.7.7.18,3.6.1.55 ko:K00969,ko:K03574,ko:K06211 ko00760,ko01100,map00760,map01100 M00115 R00137,R02324,R03005 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko03000,ko03400 iIT341.HP1337 Bacteria 1TQ29@1239,4HBZT@91061,COG1057@1,COG1057@2,COG3172@1,COG3172@2 NA|NA|NA H adenylyltransferase HLLCKODE_00819 1046629.Ssal_01196 5.9e-230 803.1 Bacilli pepT GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0034641,GO:0034701,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045148,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.11.4 ko:K01258 ko00000,ko01000,ko01002 Bacteria 1TP3A@1239,4HAZE@91061,COG2195@1,COG2195@2 NA|NA|NA E Cleaves the N-terminal amino acid of tripeptides HLLCKODE_00820 904306.HMPREF9192_1653 4.7e-85 320.5 Bacilli ebsA Bacteria 1VQ5S@1239,2FI04@1,349T2@2,4HYC5@91061 NA|NA|NA S Family of unknown function (DUF5322) HLLCKODE_00821 1046629.Ssal_01194 5.5e-17 94.7 Bacilli Bacteria 1VFEU@1239,4HNW5@91061,COG1388@1,COG1388@2 NA|NA|NA M LysM domain HLLCKODE_00822 1046629.Ssal_01193 4.3e-121 440.7 Bacilli cmk GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015939,GO:0015940,GO:0015949,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 1.17.7.4,2.5.1.19,2.7.1.26,2.7.4.25,2.7.7.2,6.3.2.1 ko:K00800,ko:K00945,ko:K02945,ko:K03527,ko:K03977,ko:K11753,ko:K13799 ko00240,ko00400,ko00410,ko00740,ko00770,ko00900,ko01100,ko01110,ko01130,ko01230,ko03010,map00240,map00400,map00410,map00740,map00770,map00900,map01100,map01110,map01130,map01230,map03010 M00022,M00052,M00096,M00119,M00125,M00178 R00158,R00161,R00512,R00549,R01665,R02473,R03460,R05884,R08210 RC00002,RC00017,RC00096,RC00141,RC00350,RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03009,ko03011 iPC815.YPO1391,iSDY_1059.SDY_2348 Bacteria 1V3IA@1239,4HFZE@91061,COG0283@1,COG0283@2 NA|NA|NA F Belongs to the cytidylate kinase family. Type 1 subfamily HLLCKODE_00823 1046629.Ssal_01192 1e-85 322.8 Bacilli infC GO:0000049,GO:0001731,GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016020,GO:0016043,GO:0019222,GO:0019538,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032268,GO:0032270,GO:0032790,GO:0032984,GO:0032988,GO:0032991,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043254,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045727,GO:0045948,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065003,GO:0065007,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901193,GO:1901195,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:1904688,GO:1904690,GO:1990856,GO:1990904,GO:2000112,GO:2000765,GO:2000767 ko:K02520 ko00000,ko03012,ko03029 Bacteria 1V1RC@1239,4HI4P@91061,COG0290@1,COG0290@2 NA|NA|NA J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins HLLCKODE_00824 1046629.Ssal_01191 8.1e-28 129.0 Bacilli rpmI GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 ko:K02916 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1VF5W@1239,4HNIQ@91061,COG0291@1,COG0291@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL35 family HLLCKODE_00825 1046629.Ssal_01190 1.5e-56 225.3 Bacilli rplT GO:0000027,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2000113,GO:2001141 ko:K02887 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V6DB@1239,4HH2W@91061,COG0292@1,COG0292@2 NA|NA|NA J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit HLLCKODE_00826 1046629.Ssal_01189 9.7e-49 199.1 Bacilli XK27_03610 Bacteria 1V77V@1239,4HKYX@91061,COG0454@1,COG0456@2 NA|NA|NA K Gnat family HLLCKODE_00827 1046629.Ssal_01188 2.8e-88 331.3 Bacilli yybC Bacteria 1V8UN@1239,2BWFV@1,32QWV@2,4HK47@91061 NA|NA|NA HLLCKODE_00828 1046629.Ssal_01187 4.9e-27 126.3 Bacilli dmpI GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0044237 5.3.2.6 ko:K01821 ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220 M00569 R03966,R05389 RC01040,RC01355 ko00000,ko00001,ko00002,ko01000 Bacteria 1VKD5@1239,4HRBS@91061,COG1942@1,COG1942@2 NA|NA|NA G Belongs to the 4-oxalocrotonate tautomerase family HLLCKODE_00829 1046629.Ssal_01186 3.4e-266 923.7 Bacilli pepV 3.5.1.18 ko:K01270,ko:K01274,ko:K01439 ko00300,ko00480,ko01100,ko01120,ko01230,map00300,map00480,map01100,map01120,map01230 M00016 R00899,R02734,R04951 RC00064,RC00090,RC00096,RC00141 ko00000,ko00001,ko00002,ko01000,ko01002 Bacteria 1TPEG@1239,4HC14@91061,COG0624@1,COG0624@2 NA|NA|NA E Dipeptidase HLLCKODE_00830 1046629.Ssal_01185 3.6e-108 397.5 Bacilli ung2 3.2.2.27 ko:K21929 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 1V1F8@1239,4HFVS@91061,COG1573@1,COG1573@2 NA|NA|NA L Uracil-DNA glycosylase HLLCKODE_00831 888048.HMPREF8577_1453 1.1e-226 793.9 Bacilli Bacteria 1VU2V@1239,4HU5W@91061,COG3266@1,COG3266@2 NA|NA|NA V Glucan-binding protein C HLLCKODE_00832 1046629.Ssal_01025 7.4e-253 880.6 Bacilli ko:K13732 ko05100,map05100 ko00000,ko00001 Bacteria 1VU2V@1239,4HU5W@91061,COG3266@1,COG3266@2 NA|NA|NA V Glucan-binding protein C HLLCKODE_00833 1046629.Ssal_01026 8.1e-120 436.4 Bacilli rpiA GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 2.7.1.12,2.7.1.15,5.3.1.6 ko:K00851,ko:K00852,ko:K01807 ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167,M00580 R01051,R01056,R01737,R02750 RC00002,RC00017,RC00434 ko00000,ko00001,ko00002,ko01000 Bacteria 1V1DB@1239,4HFQ7@91061,COG0120@1,COG0120@2 NA|NA|NA G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate HLLCKODE_00834 435842.HMPREF0848_00596 2.7e-235 820.8 Bacilli deoB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008973,GO:0016853,GO:0016866,GO:0016868,GO:0044424,GO:0044444,GO:0044464 5.4.2.7 ko:K01839 ko00030,ko00230,map00030,map00230 R01057,R02749 RC00408 ko00000,ko00001,ko01000 Bacteria 1TP70@1239,4H9RU@91061,COG1015@1,COG1015@2 NA|NA|NA G Phosphotransfer between the C1 and C5 carbon atoms of pentose HLLCKODE_00835 435842.HMPREF0848_00597 6.8e-85 320.1 Bacilli Bacteria 1V426@1239,4HI2S@91061,COG3797@1,COG3797@2 NA|NA|NA S Protein of unknown function (DUF1697) HLLCKODE_00836 1046629.Ssal_01029 7.5e-149 533.1 Bacilli punA 2.4.2.1 ko:K03783 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122 ko00000,ko00001,ko01000 Bacteria 1TQ37@1239,4HABP@91061,COG0005@1,COG0005@2 NA|NA|NA F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate HLLCKODE_00837 1123314.AUIO01000012_gene1814 3.2e-50 205.3 Bacteria ko:K03744 ko00000 Bacteria COG1704@1,COG1704@2 NA|NA|NA S LemA family HLLCKODE_00838 435842.HMPREF0848_00599 2.8e-163 581.6 Firmicutes clcA_2 ko:K03281 ko00000 2.A.49 Bacteria 1V07H@1239,COG0038@1,COG0038@2 NA|NA|NA P chloride HLLCKODE_00839 1046629.Ssal_01031 1.5e-129 468.8 Bacilli yfeJ 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 Bacteria 1V97T@1239,4HIKV@91061,COG0518@1,COG0518@2 NA|NA|NA F glutamine amidotransferase HLLCKODE_00840 435842.HMPREF0848_00601 3.2e-127 461.1 Bacilli deoD GO:0003674,GO:0003824,GO:0004731,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006152,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009116,GO:0009164,GO:0009987,GO:0015949,GO:0016740,GO:0016757,GO:0016763,GO:0019439,GO:0019686,GO:0033554,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042802,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658 2.4.2.1,2.4.2.28 ko:K00772,ko:K03784 ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110 M00034 R01402,R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122,RC02819 ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_1997,iB21_1397.B21_04226,iE2348C_1286.E2348C_4682,iEC042_1314.EC042_4881,iECABU_c1320.ECABU_c50190,iECBD_1354.ECBD_3636,iECB_1328.ECB_04260,iECD_1391.ECD_04260,iECED1_1282.ECED1_5255,iECIAI39_1322.ECIAI39_4916,iECNA114_1301.ECNA114_4626,iECO26_1355.ECO26_5590,iECOK1_1307.ECOK1_4950,iECP_1309.ECP_4768,iEcolC_1368.EcolC_3672,iLF82_1304.LF82_0467,iNRG857_1313.NRG857_22170,iPC815.YPO0440,iSFV_1184.SFV_4418,iSF_1195.SF4416,iSFxv_1172.SFxv_4809,iS_1188.S4687,iUMN146_1321.UM146_22680,iUMNK88_1353.UMNK88_5303,iUTI89_1310.UTI89_C5155,ic_1306.c5468 Bacteria 1TQPG@1239,4HADM@91061,COG0813@1,COG0813@2 NA|NA|NA F purine nucleoside phosphorylase HLLCKODE_00841 322159.STER_1071 8.8e-249 865.9 Bacilli cps4A Bacteria 1TR1B@1239,4HDRS@91061,COG1316@1,COG1316@2 NA|NA|NA K Cell envelope-like function transcriptional attenuator common domain protein HLLCKODE_00842 322159.STER_1070 5.8e-132 476.9 Bacilli cpsB 3.1.3.48 ko:K01104 ko00000,ko01000 Bacteria 1TQ1T@1239,4HDZR@91061,COG4464@1,COG4464@2 NA|NA|NA GM Capsular polysaccharide biosynthesis protein HLLCKODE_00843 435842.HMPREF0848_00604 1.2e-110 406.0 Bacilli cps4C Bacteria 1UZCR@1239,4HE26@91061,COG3944@1,COG3944@2 NA|NA|NA M biosynthesis protein HLLCKODE_00844 322159.STER_1068 5.9e-116 423.7 Bacilli cpsD Bacteria 1TS4R@1239,4HCEN@91061,COG0489@1,COG0489@2 NA|NA|NA D COG0489 ATPases involved in chromosome partitioning HLLCKODE_00845 264199.stu1108 2.7e-252 877.5 Bacilli cpsE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 1TP7M@1239,4HB3Z@91061,COG2148@1,COG2148@2 NA|NA|NA M Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase HLLCKODE_00846 904306.HMPREF9192_1679 3.1e-220 770.8 Bacilli rgpAc ko:K12996 ko00000,ko01000,ko01003,ko01005 GT4 Bacteria 1TR0Y@1239,4IPU2@91061,COG0438@1,COG0438@2 NA|NA|NA M group 1 family protein HLLCKODE_00847 1116231.SMA_0863 1.8e-212 745.0 Bacilli wcoF Bacteria 1TR6R@1239,4HEIZ@91061,COG0438@1,COG0438@2 NA|NA|NA M Glycosyltransferase, group 1 family protein HLLCKODE_00848 904306.HMPREF9192_1681 6.4e-84 316.6 Bacilli Z012_10770 Bacteria 1V8R9@1239,4HW77@91061,COG3955@1,COG3955@2 NA|NA|NA M Domain of unknown function (DUF1919) HLLCKODE_00849 862970.SAIN_1722 1.1e-173 615.9 Bacilli Bacteria 1V0TF@1239,4ISVG@91061,COG1215@1,COG1215@2 NA|NA|NA M Glycosyltransferase, group 2 family protein HLLCKODE_00850 862970.SAIN_1721 1.5e-154 552.4 Bacilli Bacteria 1V0TF@1239,4HN74@91061,COG1215@1,COG1215@2 NA|NA|NA M Glycosyltransferase like family 2 HLLCKODE_00851 862970.SAIN_1720 1.1e-172 612.8 Bacilli Bacteria 1VC7Z@1239,2BVGB@1,32U6R@2,4HNDJ@91061 NA|NA|NA HLLCKODE_00852 1069533.Sinf_0725 5.9e-250 869.8 Bacilli epsU Bacteria 1TP7R@1239,4HC84@91061,COG2244@1,COG2244@2 NA|NA|NA S Polysaccharide biosynthesis protein HLLCKODE_00853 467705.SGO_0371 4.7e-47 193.7 Bacilli Bacteria 1VK84@1239,4HN0W@91061,COG1396@1,COG1396@2 NA|NA|NA K Helix-turn-helix HLLCKODE_00854 388919.SSA_0295 2e-118 432.2 Streptococcus sanguinis mleR Bacteria 1V5VW@1239,1WQQZ@1305,4HHDY@91061,COG0583@1,COG0583@2 NA|NA|NA K malolactic fermentation system HLLCKODE_00855 1046629.Ssal_00722 2.6e-127 461.5 Bacilli XK27_00785 Bacteria 1V3A5@1239,28MHE@1,2ZAUA@2,4HZB2@91061 NA|NA|NA S CAAX protease self-immunity HLLCKODE_00856 1046629.Ssal_00721 2.9e-233 814.3 Bacteria ko:K18926 M00715 ko00000,ko00002,ko02000 2.A.1.3.30 Bacteria COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily HLLCKODE_00857 1046629.Ssal_00720 5.5e-63 246.9 Firmicutes rmaI Bacteria 1VEYN@1239,COG1846@1,COG1846@2 NA|NA|NA K Transcriptional regulator, MarR family HLLCKODE_00858 435842.HMPREF0848_01001 4.5e-92 344.0 Bacilli maa 2.3.1.79 ko:K00661 ko00000,ko01000 Bacteria 1TQEX@1239,4HAJ0@91061,COG0110@1,COG0110@2 NA|NA|NA GK Maltose O-acetyltransferase HLLCKODE_00859 904306.HMPREF9192_1436 3.4e-64 252.3 Bacteria 2.7.13.3 ko:K10681,ko:K20487 ko02020,ko02024,map02020,map02024 M00468,M00816 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria COG0642@1,COG0642@2 NA|NA|NA T Histidine kinase HLLCKODE_00860 1095726.HMPREF1116_1842 2.3e-74 285.4 Bacilli Bacteria 1V5S4@1239,4IQ3S@91061,COG0745@1,COG0745@2 NA|NA|NA K Transcriptional regulatory protein, C terminal HLLCKODE_00862 1437608.BBIA_1578 3.8e-15 89.0 Bifidobacteriales Bacteria 2B6YP@1,2H32T@201174,31ZYT@2,4D1XQ@85004 NA|NA|NA HLLCKODE_00863 1114965.Spaf_1095 6.6e-88 330.5 Bacilli ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TSUA@1239,4HEHW@91061,COG1131@1,COG1131@2 NA|NA|NA V abc transporter atp-binding protein HLLCKODE_00864 1046629.Ssal_00717 0.0 2533.4 Bacteria 3.5.1.28 ko:K01448,ko:K13733,ko:K20276 ko01503,ko02024,ko05100,map01503,map02024,map05100 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 Bacteria COG3266@1,COG3266@2,COG4932@1,COG4932@2 NA|NA|NA M domain protein HLLCKODE_00865 1046629.Ssal_00714 0.0 2354.3 Bacilli GO:0005575,GO:0005576 2.4.1.5 ko:K00689,ko:K20276 ko00500,ko02020,ko02024,map00500,map02020,map02024 R02120,R06066 RC00028 ko00000,ko00001,ko01000 GH13 Bacteria 1VQXK@1239,4HEIA@91061,COG0366@1,COG0366@2,COG5263@1,COG5263@2 NA|NA|NA M KxYKxGKxW signal domain protein HLLCKODE_00866 388919.SSA_1496 2.7e-23 115.2 Streptococcus sanguinis Bacteria 1UABR@1239,1WS3U@1305,2BI11@1,32C5S@2,4IKPW@91061 NA|NA|NA HLLCKODE_00869 904306.HMPREF9192_1022 1.1e-09 70.1 Bacilli sraP ko:K18491,ko:K21449 ko04550,map04550 ko00000,ko00001,ko02000,ko03000 1.B.40.2 Bacteria 1VIS5@1239,4HIVX@91061,COG5295@1,COG5295@2 NA|NA|NA UW domain, Protein HLLCKODE_00872 435842.HMPREF0848_01016 8.1e-150 537.0 Bacteria fliF 2.1.1.72 ko:K02409,ko:K02410,ko:K03427 ko02030,ko02040,map02030,map02040 ko00000,ko00001,ko01000,ko02035,ko02044,ko02048 3.A.6.2,3.A.6.3 Bacteria COG1766@1,COG1766@2 NA|NA|NA N bacterial-type flagellum-dependent cell motility HLLCKODE_00873 904306.HMPREF9192_1715 0.0 2003.0 Bacteria 3.5.1.28 ko:K01448,ko:K02395,ko:K21471 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko02035,ko03036 Bacteria COG0860@1,COG0860@2,COG1705@1,COG1705@2,COG3757@1,COG3757@2,COG5263@1,COG5263@2 NA|NA|NA NU amidase activity HLLCKODE_00874 1046629.Ssal_01135 1.3e-288 998.4 Bacilli lpdA 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1TP1W@1239,4H9Z5@91061,COG1249@1,COG1249@2 NA|NA|NA C Dehydrogenase HLLCKODE_00875 904306.HMPREF9192_1713 1.2e-210 739.2 Bacilli acoC 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1TR5N@1239,4HDFT@91061,COG0508@1,COG0508@2 NA|NA|NA C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex HLLCKODE_00876 1046629.Ssal_01137 6.4e-182 643.3 Bacilli acoB 1.2.4.1,1.2.4.4 ko:K00162,ko:K11381,ko:K21417 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1TP3J@1239,4HAP6@91061,COG0022@1,COG0022@2 NA|NA|NA C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit HLLCKODE_00877 1046629.Ssal_01138 1.9e-183 648.3 Bacilli acoA 1.2.4.1,1.2.4.4 ko:K00161,ko:K11381,ko:K21416 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1TQDG@1239,4HBEA@91061,COG1071@1,COG1071@2 NA|NA|NA C Dehydrogenase E1 component HLLCKODE_00878 1046629.Ssal_01139 1.3e-200 705.7 Bacteria hpk9 2.7.13.3 ko:K07706 ko02020,ko02024,map02020,map02024 M00495 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria COG3290@1,COG3290@2 NA|NA|NA T protein histidine kinase activity HLLCKODE_00879 1046629.Ssal_01140 1.6e-225 788.5 Bacteria 2.7.13.3 ko:K07706 ko02020,ko02024,map02020,map02024 M00495 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria COG3290@1,COG3290@2 NA|NA|NA T protein histidine kinase activity HLLCKODE_00880 435842.HMPREF0848_00629 2.1e-301 1041.2 Bacilli Bacteria 1TS3Q@1239,4HF7D@91061,COG4907@1,COG4907@2 NA|NA|NA S the current gene model (or a revised gene model) may contain a frame shift HLLCKODE_00881 1046629.Ssal_01152 5e-232 810.1 Bacilli pyrC GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPQM@1239,4HA90@91061,COG0044@1,COG0044@2 NA|NA|NA F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily HLLCKODE_00882 904306.HMPREF9192_1707 1.6e-120 438.7 Bacilli ung GO:0003674,GO:0003824,GO:0004844,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097510,GO:0140097,GO:1901360 3.2.2.27 ko:K03648 ko03410,ko05340,map03410,map05340 ko00000,ko00001,ko01000,ko03400 Bacteria 1TPSN@1239,4HBTR@91061,COG0692@1,COG0692@2 NA|NA|NA L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine HLLCKODE_00883 1046629.Ssal_01154 5.4e-212 743.4 Bacilli yeaB Bacteria 1TSGY@1239,4H9WP@91061,COG0053@1,COG0053@2,COG4994@1,COG4994@2 NA|NA|NA K Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family HLLCKODE_00884 1046629.Ssal_01155 1.7e-246 858.2 Bacilli dacA1 3.4.16.4 ko:K01286,ko:K07258 ko00550,ko01100,map00550,map01100 ko00000,ko00001,ko01000,ko01002,ko01011 Bacteria 1TQN0@1239,4HD0P@91061,COG1686@1,COG1686@2 NA|NA|NA M Belongs to the peptidase S11 family HLLCKODE_00885 1046629.Ssal_01156 2.4e-153 548.1 Bacilli rssA Bacteria 1TQ9W@1239,4HCHJ@91061,COG4667@1,COG4667@2 NA|NA|NA S Phospholipase, patatin family HLLCKODE_00886 904306.HMPREF9192_1701 8.4e-100 369.8 Bacilli estA Bacteria 1VHUN@1239,4IPN1@91061,COG2755@1,COG2755@2 NA|NA|NA E Lysophospholipase L1 and related esterases HLLCKODE_00887 1046629.Ssal_01158 9.8e-278 962.2 Bacilli ko:K03688 ko00000 Bacteria 1TPIV@1239,4HBW3@91061,COG0661@1,COG0661@2 NA|NA|NA S unusual protein kinase HLLCKODE_00888 1046629.Ssal_01159 4.1e-38 163.7 Bacilli Bacteria 1VK6K@1239,4HRS5@91061,COG3937@1,COG3937@2 NA|NA|NA S granule-associated protein HLLCKODE_00889 1046629.Ssal_01160 9.8e-285 985.3 Bacilli bglH 3.2.1.86 ko:K01223 ko00010,ko00500,map00010,map00500 R00839,R05133,R05134 RC00049,RC00171,RC00714 ko00000,ko00001,ko01000 GT1 Bacteria 1TP19@1239,4HA1W@91061,COG2723@1,COG2723@2 NA|NA|NA G Belongs to the glycosyl hydrolase 1 family HLLCKODE_00890 1046629.Ssal_01161 1.5e-195 688.7 Bacilli Bacteria 1TQBF@1239,4HGFS@91061,COG0628@1,COG0628@2 NA|NA|NA S hmm pf01594 HLLCKODE_00891 904306.HMPREF9192_1694 2.1e-103 381.7 Bacilli Bacteria 1UXY8@1239,4HFD9@91061,COG0406@1,COG0406@2 NA|NA|NA G Belongs to the phosphoglycerate mutase family HLLCKODE_00892 904306.HMPREF9192_1693 1.7e-108 398.7 Bacilli Bacteria 1UXY8@1239,4HFD9@91061,COG0406@1,COG0406@2 NA|NA|NA G Belongs to the phosphoglycerate mutase family HLLCKODE_00893 904306.HMPREF9192_1692 1.6e-108 398.7 Bacilli pgm Bacteria 1UXY8@1239,4HFD9@91061,COG0406@1,COG0406@2 NA|NA|NA G Belongs to the phosphoglycerate mutase family HLLCKODE_00894 1046629.Ssal_01165 1e-137 496.1 Bacilli supH 3.1.3.102,3.1.3.104 ko:K20861 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00548,R07280 RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 1V1SQ@1239,4IPTG@91061,COG0561@1,COG0561@2 NA|NA|NA S Sucrose-6F-phosphate phosphohydrolase HLLCKODE_00896 1069533.Sinf_0729 8.7e-190 669.5 Bacilli wbbI GO:0003674,GO:0003824,GO:0008194,GO:0008378,GO:0008921,GO:0016740,GO:0016757,GO:0016758,GO:0035250 iAF1260.b2034,iBWG_1329.BWG_1824,iECDH10B_1368.ECDH10B_2184,iECDH1ME8569_1439.ECDH1ME8569_1971,iECSF_1327.ECSF_1923,iEcDH1_1363.EcDH1_1623,iJO1366.b2034,iY75_1357.Y75_RS10645 Bacteria 1UZFG@1239,4ISTK@91061,COG0438@1,COG0438@2 NA|NA|NA M transferase activity, transferring glycosyl groups HLLCKODE_00897 904306.HMPREF9192_1687 2.5e-186 657.9 Bacilli sacB ko:K20444 ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 Bacteria 1TPG9@1239,4HGEP@91061,COG0438@1,COG0438@2 NA|NA|NA M Stealth protein CR2, conserved region 2 HLLCKODE_00898 1069533.Sinf_0727 1.7e-215 755.0 Bacilli glf GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008767,GO:0009273,GO:0009987,GO:0016020,GO:0016853,GO:0016866,GO:0030312,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0071554,GO:0071766,GO:0071840,GO:0071944,GO:0097159,GO:1901265,GO:1901363 5.4.99.9 ko:K01854 ko00052,ko00520,map00052,map00520 R00505,R09009 RC00317,RC02396 ko00000,ko00001,ko01000 iNJ661.Rv3809c Bacteria 1TQB9@1239,4HB5F@91061,COG0562@1,COG0562@2 NA|NA|NA M UDP-galactopyranose mutase HLLCKODE_00899 1046629.Ssal_01199 1.6e-94 352.1 Bacilli lepB 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 ko00000,ko00001,ko01000,ko01002 Bacteria 1V2BJ@1239,4HGCB@91061,COG0681@1,COG0681@2 NA|NA|NA U Belongs to the peptidase S26 family HLLCKODE_00900 1046629.Ssal_01200 4.5e-222 776.9 Bacilli Bacteria 1TT97@1239,4HAIA@91061,COG0457@1,COG0457@2 NA|NA|NA G COG0457 FOG TPR repeat HLLCKODE_00901 1046629.Ssal_01201 1.8e-175 622.1 Bacilli yubA Bacteria 1TQ84@1239,4H9SR@91061,COG0628@1,COG0628@2 NA|NA|NA S permease HLLCKODE_00902 1046629.Ssal_01202 7.3e-91 339.7 Bacilli mutX 3.6.1.55 ko:K03574 ko00000,ko01000,ko03400 Bacteria 1V66I@1239,4HHRE@91061,COG1051@1,COG1051@2 NA|NA|NA F NTP pyrophosphohydrolases including oxidative damage repair enzymes HLLCKODE_00903 904306.HMPREF9192_1646 7.3e-164 583.2 Bacilli ftsX GO:0000910,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0007154,GO:0007165,GO:0007166,GO:0008150,GO:0008356,GO:0009966,GO:0009987,GO:0010033,GO:0010646,GO:0016020,GO:0016021,GO:0016043,GO:0019221,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0023052,GO:0030312,GO:0031224,GO:0031226,GO:0032506,GO:0034097,GO:0040007,GO:0042173,GO:0042221,GO:0043937,GO:0043938,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051301,GO:0051716,GO:0065007,GO:0070098,GO:0070297,GO:0070887,GO:0071310,GO:0071345,GO:0071840,GO:0071944,GO:0090529,GO:1902531 ko:K09811,ko:K09812 ko02010,map02010 M00256 ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 Bacteria 1TPND@1239,4HA5A@91061,COG2177@1,COG2177@2 NA|NA|NA D Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation HLLCKODE_00904 1046629.Ssal_01204 3.2e-124 451.1 Bacilli ftsE GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0019897,GO:0019898,GO:0030554,GO:0031234,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363 ko:K09811,ko:K09812 ko02010,map02010 M00256 ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 Bacteria 1TP58@1239,4H9Z2@91061,COG2884@1,COG2884@2 NA|NA|NA D cell division ATP-binding protein FtsE HLLCKODE_00905 1046629.Ssal_01205 2.1e-182 644.8 Bacilli prfB GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02836 ko00000,ko03012 Bacteria 1TPSB@1239,4H9N2@91061,COG1186@1,COG1186@2 NA|NA|NA J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA HLLCKODE_00906 1046629.Ssal_01206 3.5e-205 720.7 Bacilli queG GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 ko:K18979 ko00000,ko01000,ko03016 Bacteria 1TP6Q@1239,4HAEW@91061,COG1600@1,COG1600@2 NA|NA|NA C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) HLLCKODE_00907 1046629.Ssal_01207 4.4e-152 543.9 Bacilli yjjH Bacteria 1V9B5@1239,4HJX0@91061,COG1409@1,COG1409@2 NA|NA|NA S Calcineurin-like phosphoesterase HLLCKODE_00908 904306.HMPREF9192_1641 2.7e-129 468.0 Bacilli nfrA 1.5.1.38,1.5.1.39 ko:K19285,ko:K19286 ko00740,ko01100,map00740,map01100 R05705,R05706 RC00126 ko00000,ko00001,ko01000 Bacteria 1UB8S@1239,4HEGP@91061,COG0778@1,COG0778@2 NA|NA|NA C nitroreductase HLLCKODE_00909 1046629.Ssal_01209 0.0 1609.7 Bacilli pacL 3.6.3.8 ko:K01537 ko00000,ko01000 3.A.3.2 Bacteria 1TPF5@1239,4H9S5@91061,COG0474@1,COG0474@2 NA|NA|NA P cation transport ATPase HLLCKODE_00910 1046629.Ssal_01211 1.2e-67 262.3 Bacteria ywiB Bacteria COG4506@1,COG4506@2 NA|NA|NA S Domain of unknown function (DUF1934) HLLCKODE_00911 1046629.Ssal_01213 5e-135 487.3 Bacilli XK27_00115 2.3.1.128 ko:K03789 ko00000,ko01000,ko03009 Bacteria 1VD7Z@1239,4HGYD@91061,COG0454@1,COG0456@2 NA|NA|NA K Acetyltransferase GNAT family HLLCKODE_00912 435842.HMPREF0848_00565 7.8e-146 523.1 Bacilli yidA GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050308 Bacteria 1TR16@1239,4HCZ6@91061,COG0561@1,COG0561@2 NA|NA|NA S hydrolases of the HAD superfamily HLLCKODE_00913 904306.HMPREF9192_1635 4.3e-225 786.9 Bacilli murM 2.3.2.10,2.3.2.16 ko:K05363,ko:K11693 ko00550,ko01100,map00550,map01100 R08776,R08779 RC00055,RC00096 ko00000,ko00001,ko01000,ko01011 Bacteria 1TRZU@1239,4HC1Z@91061,COG2348@1,COG2348@2 NA|NA|NA V protein involved in methicillin resistance HLLCKODE_00914 435842.HMPREF0848_00563 9.7e-56 222.6 Bacilli ko:K09790 ko00000 Bacteria 1VC3R@1239,4HMWE@91061,COG2832@1,COG2832@2 NA|NA|NA S Protein of unknown function (DUF454) HLLCKODE_00915 1046629.Ssal_01219 2.7e-154 551.2 Bacilli vicX 3.1.26.11 ko:K00784 ko03013,map03013 ko00000,ko00001,ko01000,ko03016 Bacteria 1TQ8E@1239,4HAKD@91061,COG1235@1,COG1235@2 NA|NA|NA S Metal-dependent hydrolases of the beta-lactamase superfamily I HLLCKODE_00916 1046629.Ssal_01220 9.6e-234 815.8 Bacilli vicK 2.7.13.3 ko:K07652 ko02020,map02020 M00459 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1TQ1H@1239,4HA52@91061,COG5002@1,COG5002@2 NA|NA|NA T Histidine kinase HLLCKODE_00917 904306.HMPREF9192_1631 6.4e-128 463.4 Bacilli Bacteria 1TPQG@1239,4HA8Q@91061,COG0745@1,COG0745@2 NA|NA|NA KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain HLLCKODE_00918 904306.HMPREF9192_1626 1.6e-140 505.4 Bacilli glnQ 3.6.3.21 ko:K02028,ko:K10041 ko02010,map02010 M00228,M00236 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3 Bacteria 1TNYD@1239,4H9WY@91061,COG1126@1,COG1126@2 NA|NA|NA E abc transporter atp-binding protein HLLCKODE_00919 904306.HMPREF9192_1625 1.8e-142 511.9 Firmicutes peb1A GO:0005575,GO:0005623,GO:0009986,GO:0044464 ko:K10039 ko02010,map02010 M00228 ko00000,ko00001,ko00002,ko02000 3.A.1.3 Bacteria 1TT11@1239,COG0834@1,COG0834@2 NA|NA|NA ET Belongs to the bacterial solute-binding protein 3 family HLLCKODE_00920 904306.HMPREF9192_1624 1.9e-116 425.2 Bacilli gltJ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02029,ko:K10003,ko:K10040 ko02010,ko02020,map02010,map02020 M00228,M00230,M00236 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.19,3.A.1.3.4 iJN746.PP_1070 Bacteria 1TQ5K@1239,4HE9C@91061,COG0765@1,COG0765@2 NA|NA|NA P ABC transporter (Permease HLLCKODE_00921 1046629.Ssal_01225 5e-111 407.1 Bacilli tcyB_2 ko:K02029,ko:K02030,ko:K10040,ko:K17073,ko:K17074 ko02010,map02010 M00228,M00236,M00589 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.20 Bacteria 1V14N@1239,4HJ9W@91061,COG0765@1,COG0765@2 NA|NA|NA P ABC transporter (permease) HLLCKODE_00922 904306.HMPREF9192_1622 1.3e-154 552.4 Bacilli endA ko:K15051 ko00000 Bacteria 1V4X2@1239,4HIF5@91061,COG2169@1,COG2169@2 NA|NA|NA F DNA RNA non-specific endonuclease HLLCKODE_00923 1046629.Ssal_01228 2.7e-25 120.6 Bacilli epuA Bacteria 1VMAH@1239,2EK0E@1,33DQZ@2,4HRG1@91061 NA|NA|NA S DNA-directed RNA polymerase subunit beta HLLCKODE_00924 1046629.Ssal_01229 1.6e-230 805.1 Bacilli murA 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 R00660 RC00350 ko00000,ko00001,ko01000,ko01011 Bacteria 1TPAU@1239,4H9KI@91061,COG0766@1,COG0766@2 NA|NA|NA M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine HLLCKODE_00925 435842.HMPREF0848_00551 1e-193 682.6 Bacilli Bacteria 1VCBY@1239,4IPTW@91061,COG3405@1,COG3405@2 NA|NA|NA G Belongs to the glycosyl hydrolase 8 (cellulase D) family HLLCKODE_00926 435842.HMPREF0848_00550 7.4e-247 859.4 Bacilli ydaM Bacteria 1TRCI@1239,4HAAK@91061,COG1215@1,COG1215@2 NA|NA|NA M Glycosyltransferases, probably involved in cell wall biogenesis HLLCKODE_00928 435842.HMPREF0848_00549 1e-131 476.1 Bacilli Bacteria 1W0IB@1239,2DSSB@1,33H90@2,4HYWM@91061 NA|NA|NA HLLCKODE_00929 435842.HMPREF0848_00548 2.5e-214 751.1 Bacilli mnaA 5.1.3.14 ko:K01791 ko00520,ko01100,ko05111,map00520,map01100,map05111 M00362 R00420 RC00290 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria 1TQZT@1239,4HBI3@91061,COG0381@1,COG0381@2 NA|NA|NA G Belongs to the UDP-N-acetylglucosamine 2-epimerase family HLLCKODE_00930 1046629.Ssal_01529 1.3e-63 248.8 Bacilli yugI 5.3.1.9 ko:K01810,ko:K02945,ko:K07570,ko:K07571,ko:K19142 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko03010,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map03010 M00001,M00004,M00114,M00178 R02739,R02740,R03321 RC00376,RC00563 br01610,ko00000,ko00001,ko00002,ko01000,ko02048,ko03011,ko04147 Bacteria 1VASQ@1239,4HKSW@91061,COG1098@1,COG1098@2 NA|NA|NA J RNA binding protein, contains ribosomal protein S1 domain HLLCKODE_00931 1046629.Ssal_01530 9e-275 952.2 Bacilli ppiB GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564 5.2.1.8 ko:K01802,ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 ko00000,ko00001,ko01000,ko03110,ko04147 Bacteria 1TRHW@1239,4H9V0@91061,COG0561@1,COG0561@2,COG0652@1,COG0652@2 NA|NA|NA G PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides HLLCKODE_00932 1046629.Ssal_01531 6.6e-81 306.6 Bacilli smpB GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0070930,GO:0071704,GO:0097159,GO:1901363,GO:1901564 ko:K03664 ko00000 Bacteria 1V3IJ@1239,4HGZX@91061,COG0691@1,COG0691@2 NA|NA|NA O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA HLLCKODE_00933 1046629.Ssal_01532 0.0 1454.9 Bacilli rnr ko:K12573,ko:K12585 ko03018,map03018 M00391 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 Bacteria 1TQ1G@1239,4HBBH@91061,COG0557@1,COG0557@2 NA|NA|NA J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs HLLCKODE_00934 904306.HMPREF9192_1354 2e-33 147.9 Bacilli secG GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 Bacteria 1VEQR@1239,4HNKC@91061,COG1314@1,COG1314@2 NA|NA|NA U Preprotein translocase subunit SecG HLLCKODE_00935 1046629.Ssal_01534 1e-221 775.8 Bacilli mdtG GO:0006810,GO:0006855,GO:0008150,GO:0015893,GO:0042221,GO:0042493,GO:0050896,GO:0051179,GO:0051234,GO:0055085 ko:K08161 ko00000,ko02000 2.A.1.2.20 Bacteria 1TRDJ@1239,4H9Q9@91061,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily HLLCKODE_00936 1046629.Ssal_01535 4e-91 340.9 Bacilli coaE GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24,3.2.2.23,4.2.99.18 ko:K00859,ko:K08309,ko:K10563 ko00770,ko01100,ko03410,map00770,map01100,map03410 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01011,ko03400 GH23 iIT341.HP0831 Bacteria 1V6FS@1239,4HII3@91061,COG0237@1,COG0237@2 NA|NA|NA H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A HLLCKODE_00937 435842.HMPREF0848_00250 9.9e-109 399.4 Bacilli fpg 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 1TPM9@1239,4H9Q7@91061,COG0266@1,COG0266@2 NA|NA|NA L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates HLLCKODE_00938 1046629.Ssal_01539 1.7e-165 588.6 Bacilli era GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006275,GO:0008150,GO:0008156,GO:0009889,GO:0009890,GO:0009892,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051302,GO:0051781,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:2000104,GO:2000112,GO:2000113 ko:K03595,ko:K06883 ko00000,ko03009,ko03029 Bacteria 1TP3R@1239,4H9WF@91061,COG1159@1,COG1159@2 NA|NA|NA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism HLLCKODE_00939 1046629.Ssal_01540 4.4e-65 253.8 Bacilli dgkA 2.7.1.107,2.7.1.66 ko:K00887,ko:K00901 ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231 R02240,R05626 RC00002,RC00017 ko00000,ko00001,ko01000 iAF987.Gmet_2369,iSB619.SA_RS07900 Bacteria 1VEGR@1239,4HNKN@91061,COG0818@1,COG0818@2 NA|NA|NA M Diacylglycerol kinase HLLCKODE_00940 1046629.Ssal_01541 3e-87 327.8 Bacilli ybeY GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 2.6.99.2,3.5.4.5 ko:K01489,ko:K03474,ko:K03595,ko:K07042 ko00240,ko00750,ko00983,ko01100,map00240,map00750,map00983,map01100 M00124 R01878,R02485,R05838,R08221 RC00074,RC00514,RC01476 ko00000,ko00001,ko00002,ko01000,ko03009,ko03029 Bacteria 1V6BU@1239,4HIIE@91061,COG0319@1,COG0319@2 NA|NA|NA S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA HLLCKODE_00941 1046629.Ssal_01542 1.3e-143 515.8 Bacilli licT ko:K02538,ko:K03488 ko00000,ko03000 Bacteria 1TT5A@1239,4HC5Y@91061,COG3711@1,COG3711@2 NA|NA|NA K antiterminator HLLCKODE_00942 1046629.Ssal_01543 1.3e-105 389.0 Bacilli recR GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 ko:K06187 ko03440,map03440 ko00000,ko00001,ko03400 Bacteria 1TR87@1239,4HAZR@91061,COG0353@1,COG0353@2 NA|NA|NA L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO HLLCKODE_00943 1046629.Ssal_01544 0.0 1223.0 Bacilli pbp2b 3.4.16.4 ko:K00687,ko:K05515,ko:K12553,ko:K21465 ko00550,ko01100,ko01501,map00550,map01100,map01501 ko00000,ko00001,ko01000,ko01011 Bacteria 1TQHY@1239,4HAFX@91061,COG0768@1,COG0768@2 NA|NA|NA M penicillin-binding protein HLLCKODE_00944 1046629.Ssal_01545 2.4e-142 511.5 Bacilli nnrD 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 ko00000,ko01000 Bacteria 1TNZE@1239,4HBZC@91061,COG0063@1,COG0063@2 NA|NA|NA H Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration HLLCKODE_00945 904306.HMPREF9192_1342 2.4e-153 548.1 Bacilli folD GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP1P@1239,4H9Q6@91061,COG0190@1,COG0190@2 NA|NA|NA F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate HLLCKODE_00946 1046629.Ssal_01547 6.1e-148 530.0 Bacilli Bacteria 1V37Y@1239,4ITDD@91061,COG2267@1,COG2267@2 NA|NA|NA I Alpha/beta hydrolase family HLLCKODE_00947 759913.SDSE_1600 6.6e-08 62.4 Streptococcus dysgalactiae group Bacteria 1MA5P@119603,1TXF8@1239,2DJ8A@1,304YV@2,4I6DK@91061 NA|NA|NA HLLCKODE_00948 1046629.Ssal_01549 0.0 1346.3 Bacilli feoB ko:K04759 ko00000,ko02000 9.A.8.1 Bacteria 1TP7E@1239,4HBCS@91061,COG0370@1,COG0370@2 NA|NA|NA P transporter of a GTP-driven Fe(2 ) uptake system HLLCKODE_00949 904306.HMPREF9192_1338 1.6e-77 295.4 Bacilli feoA ko:K04758 ko00000,ko02000 Bacteria 1VEHC@1239,4HPFS@91061,COG1918@1,COG1918@2 NA|NA|NA P FeoA domain protein HLLCKODE_00950 1046629.Ssal_01552 5.4e-130 470.3 Bacilli glnQ 3.6.3.21 ko:K02028 M00236 ko00000,ko00002,ko01000,ko02000 3.A.1.3 Bacteria 1TNYD@1239,4H9WY@91061,COG1126@1,COG1126@2 NA|NA|NA E abc transporter atp-binding protein HLLCKODE_00951 1046629.Ssal_01553 1.7e-117 428.7 Bacilli WQ51_01820 ko:K02029,ko:K02030,ko:K10040,ko:K17073,ko:K17074 ko02010,map02010 M00228,M00236,M00589 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.20 Bacteria 1TPM3@1239,4IQKK@91061,COG0765@1,COG0765@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component HLLCKODE_00952 1046629.Ssal_01554 1e-34 152.1 Bacilli ykuJ Bacteria 1VKD0@1239,4HRGC@91061,COG4703@1,COG4703@2 NA|NA|NA S protein conserved in bacteria HLLCKODE_00953 1046629.Ssal_01556 3.4e-180 637.5 Bacilli argF GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPF2@1239,4H9X8@91061,COG0078@1,COG0078@2 NA|NA|NA E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline HLLCKODE_00954 904306.HMPREF9192_1333 0.0 1307.0 Bacilli clpE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03697 ko00000,ko03110 Bacteria 1TPMU@1239,4HA0V@91061,COG0542@1,COG0542@2 NA|NA|NA O Belongs to the ClpA ClpB family HLLCKODE_00955 1046629.Ssal_01558 2.2e-84 318.2 Bacilli mutT 3.5.4.33,3.6.1.13,3.6.1.55 ko:K01515,ko:K03574,ko:K11991 ko00230,map00230 R01054,R10223 RC00002,RC00477 ko00000,ko00001,ko01000,ko03016,ko03400 Bacteria 1VH6Q@1239,4HQVJ@91061,COG0494@1,COG0494@2 NA|NA|NA L Belongs to the Nudix hydrolase family HLLCKODE_00956 1046629.Ssal_01559 6.2e-48 196.4 Bacilli XK27_09445 Bacteria 1VFRS@1239,2EBZ8@1,335YI@2,4HNUK@91061 NA|NA|NA S Domain of unknown function (DUF1827) HLLCKODE_00957 1046629.Ssal_01560 1.3e-171 609.0 Bacilli ko:K22230 ko00562,ko01120,map00562,map01120 R09954 RC00182 ko00000,ko00001,ko01000 Bacteria 1TQSS@1239,4HDXF@91061,COG0673@1,COG0673@2 NA|NA|NA S oxidoreductase HLLCKODE_00958 435842.HMPREF0848_00231 2.5e-228 797.7 Bacilli murN 2.3.2.16 ko:K11693,ko:K12554 ko00550,ko01100,map00550,map01100 R08776,R08780 RC00055,RC00064,RC00096 ko00000,ko00001,ko01000,ko01011 Bacteria 1V181@1239,4HEVU@91061,COG2348@1,COG2348@2 NA|NA|NA V FemAB family HLLCKODE_00959 1046629.Ssal_01562 7.1e-116 423.3 Bacteria Bacteria COG0398@1,COG0398@2 NA|NA|NA M Pfam SNARE associated Golgi protein HLLCKODE_00960 1046629.Ssal_01563 2.1e-106 391.7 Bacilli Bacteria 1VGN9@1239,2DMIQ@1,32RV1@2,4I0DZ@91061 NA|NA|NA S Domain of Unknown Function with PDB structure (DUF3862) HLLCKODE_00963 891391.LAC30SC_09790 1.2e-23 117.5 Lactobacillaceae GO:0003674,GO:0003824,GO:0006464,GO:0006486,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009403,GO:0009404,GO:0009987,GO:0016740,GO:0016757,GO:0016999,GO:0017000,GO:0017144,GO:0018193,GO:0018198,GO:0018240,GO:0018280,GO:0019538,GO:0019748,GO:0030152,GO:0030650,GO:0030651,GO:0034641,GO:0034645,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043413,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044550,GO:0046224,GO:0070085,GO:0071704,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 Bacteria 1UV29@1239,3F8S5@33958,4I29G@91061,COG0463@1,COG0463@2 NA|NA|NA M Glycosyl transferase family 2 HLLCKODE_00964 889201.HMPREF9422_1125 1.2e-172 613.6 Bacilli comA GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015399,GO:0015405,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043492,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944 ko:K06147,ko:K06148,ko:K12292,ko:K20344 ko02010,ko02020,ko02024,map02010,map02020,map02024 ko00000,ko00001,ko01000,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.112,3.A.1.112.1,3.A.1.21 Bacteria 1V77J@1239,4HAX2@91061,COG2274@1,COG2274@2 NA|NA|NA V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain HLLCKODE_00965 888816.HMPREF9389_1289 2.2e-46 191.4 Streptococcus sanguinis coiA 3.6.4.12 ko:K03657,ko:K06198 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 1TRGD@1239,1WR4E@1305,4HFP5@91061,COG4469@1,COG4469@2 NA|NA|NA S Competence protein HLLCKODE_00966 1046629.Ssal_02110 7.2e-186 656.4 Bacilli Bacteria 1TRSF@1239,4HDM3@91061,COG2826@1,COG2826@2 NA|NA|NA L PFAM Integrase, catalytic core HLLCKODE_00967 435842.HMPREF0848_00956 6e-20 103.2 Firmicutes Bacteria 1UXB4@1239,COG2304@1,COG2304@2,COG4932@1,COG4932@2 NA|NA|NA M Pilin isopeptide linkage domain protein HLLCKODE_00968 1114965.Spaf_1573 8.2e-233 813.1 Bacteria Bacteria COG4932@1,COG4932@2 NA|NA|NA M domain protein HLLCKODE_00969 596329.HMPREF0631_1001 6.7e-89 333.6 Peptostreptococcaceae Bacteria 1TR4Y@1239,24DHJ@186801,25U8C@186804,COG0500@1,COG2226@2 NA|NA|NA H Methyltransferase HLLCKODE_00970 1314.HKU360_01262 2e-21 109.8 Bacilli XK27_10050 Bacteria 1VDKY@1239,4IS6B@91061,COG1396@1,COG1396@2,COG2932@1,COG2932@2 NA|NA|NA K Peptidase S24-like HLLCKODE_00973 1095737.HMPREF1110_0132 5.2e-62 243.4 Streptococcus mitis XK27_00590 Bacteria 1W4PT@1239,2EV5A@1,2TPNW@28037,33NK4@2,4IE5K@91061 NA|NA|NA HLLCKODE_00974 365659.smi_0789 2.5e-62 244.6 Streptococcus mitis Bacteria 1U4E9@1239,2TPR2@28037,30941@2,4IE6S@91061,COG1393@1 NA|NA|NA P arsenate reductase (glutaredoxin) activity HLLCKODE_00975 1000588.HMPREF9965_1552 9.7e-36 156.4 Streptococcus mitis XK27_00545 Bacteria 1TPDR@1239,2TPGV@28037,4HUB9@91061,COG3451@1,COG3451@2 NA|NA|NA U This gene contains a nucleotide ambiguity which may be the result of a sequencing error HLLCKODE_00976 1095737.HMPREF1110_0155 3.4e-34 151.0 Streptococcus mitis Bacteria 1UENC@1239,29UH6@1,2TPY1@28037,30FU7@2,4IEA1@91061 NA|NA|NA HLLCKODE_00977 171101.spr0951 1.8e-81 308.5 Streptococcus pneumoniae nprA ko:K18830,ko:K20480 ko02024,map02024 ko00000,ko00001,ko02048,ko03000 Bacteria 1U4BP@1239,1WURA@1313,4IE3G@91061,COG1396@1,COG1396@2 NA|NA|NA K Cro/C1-type HTH DNA-binding domain HLLCKODE_00978 1035187.HMPREF9959_0065 1.7e-126 458.8 Streptococcus mitis 2.7.1.176 ko:K07452,ko:K16214 ko00000,ko01000,ko02048 Bacteria 1V4WZ@1239,2TNQ5@28037,4HIER@91061,COG0542@1,COG0542@2 NA|NA|NA O Zeta toxin HLLCKODE_00979 585204.SMSK597_1875 3.5e-163 580.9 Streptococcus mitis xerC ko:K03733,ko:K04763 ko00000,ko03036 Bacteria 1TQRG@1239,2TPS1@28037,4IQMI@91061,COG4974@1,COG4974@2 NA|NA|NA L Phage integrase family HLLCKODE_00981 862971.SANR_1182 5.6e-154 550.4 Bacilli 6.3.2.2,6.3.2.4 ko:K01919,ko:K01921 ko00270,ko00473,ko00480,ko00550,ko01100,ko01502,map00270,map00473,map00480,map00550,map01100,map01502 M00118 R00894,R01150,R10993 RC00064,RC00090,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011 Bacteria 1W0E5@1239,4HZD5@91061,COG1181@1,COG1181@2 NA|NA|NA M Belongs to the D-alanine--D-alanine ligase family HLLCKODE_00982 1046629.Ssal_00550 0.0 1738.4 Bacilli valS GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iLJ478.TM1817 Bacteria 1TPN4@1239,4HB85@91061,COG0525@1,COG0525@2 NA|NA|NA J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner HLLCKODE_00984 1046629.Ssal_00548 6.5e-99 366.7 Bacilli rimL 2.3.1.128,5.2.1.8 ko:K03768,ko:K03790 ko00000,ko01000,ko03009,ko03110 Bacteria 1V2C6@1239,4HG3C@91061,COG1670@1,COG1670@2 NA|NA|NA J COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins HLLCKODE_00985 435842.HMPREF0848_00106 7.1e-101 373.2 Bacilli Bacteria 1VENC@1239,4HQ31@91061,COG1853@1,COG1853@2 NA|NA|NA S COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family HLLCKODE_00988 1123314.AUIO01000005_gene141 3e-14 84.0 Bacilli coiA 3.6.4.12 ko:K03657,ko:K06198 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 1TRGD@1239,4HFP5@91061,COG4469@1,COG4469@2 NA|NA|NA S Competence protein HLLCKODE_00989 1123309.AQYB01000025_gene1776 3.4e-16 92.0 Bacteria Bacteria COG3212@1,COG3212@2 NA|NA|NA T peptidase HLLCKODE_00990 264199.stu0471 2.9e-146 524.6 Bacilli rarD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016021,GO:0031224,GO:0044425,GO:0044464,GO:0071944 ko:K05786 ko00000,ko02000 2.A.7.7 Bacteria 1TQF2@1239,4HAYU@91061,COG2962@1,COG2962@2 NA|NA|NA S Transporter HLLCKODE_00991 1046629.Ssal_01693 3.5e-152 544.3 Bacilli thrB GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.1.39 ko:K00872 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 iECSE_1348.ECSE_0003,iJN678.thrB,iLJ478.TM0545 Bacteria 1TRWS@1239,4HCQN@91061,COG0083@1,COG0083@2 NA|NA|NA E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate HLLCKODE_00992 1046629.Ssal_01694 2.6e-236 824.3 Bacilli hom GO:0003674,GO:0003824,GO:0004412,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.3,2.7.2.4 ko:K00003,ko:K12524 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00017,M00018,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1294,iSB619.SA_RS06610 Bacteria 1TQ2H@1239,4HBAP@91061,COG0460@1,COG0460@2 NA|NA|NA E homoserine dehydrogenase HLLCKODE_00993 435842.HMPREF0848_00100 1.4e-132 479.2 Bacilli yxkH Bacteria 1V6AW@1239,4HHC9@91061,COG0726@1,COG0726@2 NA|NA|NA G deacetylase HLLCKODE_00994 1046629.Ssal_01696 5.7e-203 713.4 Bacilli argD GO:0003674,GO:0003824,GO:0003992,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 1TP9S@1239,4H9VZ@91061,COG4992@1,COG4992@2 NA|NA|NA E acetylornithine aminotransferase HLLCKODE_00995 1046629.Ssal_01697 3.8e-123 447.6 Firmicutes argB GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP0N@1239,COG0548@1,COG0548@2 NA|NA|NA E Belongs to the acetylglutamate kinase family. ArgB subfamily HLLCKODE_00996 435842.HMPREF0848_00097 8.6e-218 762.7 Bacilli argJ GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35,2.7.2.8 ko:K00620,ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282,R02649 RC00002,RC00004,RC00043,RC00064 ko00000,ko00001,ko00002,ko01000 iLJ478.TM1783 Bacteria 1TPBP@1239,4H9TQ@91061,COG1364@1,COG1364@2 NA|NA|NA E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate HLLCKODE_00997 1046629.Ssal_01699 2.5e-181 641.3 Bacilli argC GO:0003674,GO:0003824,GO:0003942,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 iLJ478.TM1782,iSSON_1240.SSON_4131,iYO844.BSU11190 Bacteria 1TPVI@1239,4H9YD@91061,COG0002@1,COG0002@2 NA|NA|NA E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde HLLCKODE_00998 904306.HMPREF9192_0375 2.6e-222 777.7 Bacilli mtnE 2.6.1.83 ko:K08969,ko:K10206 ko00270,ko00300,ko01100,ko01110,ko01130,ko01230,map00270,map00300,map01100,map01110,map01130,map01230 M00034,M00527 R07396,R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 1TQD6@1239,4HAHQ@91061,COG0436@1,COG0436@2 NA|NA|NA E mutations do not affect methionine salvage in vivo however HLLCKODE_00999 904306.HMPREF9192_0374 1.2e-140 505.8 Bacilli cnhA 3.5.1.3 ko:K11206,ko:K13566 ko00250,map00250 R00269,R00348 RC00010 ko00000,ko00001,ko01000 Bacteria 1TQDK@1239,4HC44@91061,COG0388@1,COG0388@2 NA|NA|NA S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase HLLCKODE_01000 904306.HMPREF9192_0370 0.0 2018.8 Bacilli vanY 3.4.17.14,3.5.1.28 ko:K01448,ko:K02395,ko:K07260 ko00550,ko01100,ko01502,ko01503,ko02020,map00550,map01100,map01502,map01503,map02020 M00651,M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504,ko02035,ko03036 Bacteria 1V1F7@1239,4ISN5@91061,COG0739@1,COG0739@2,COG0860@1,COG0860@2,COG1705@1,COG1705@2,COG1876@1,COG1876@2,COG3757@1,COG3757@2 NA|NA|NA M D-alanyl-D-alanine carboxypeptidase HLLCKODE_01002 435842.HMPREF0848_00088 6.4e-230 803.1 Bacilli 2.7.13.3 ko:K07706 ko02020,ko02024,map02020,map02024 M00495 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1UYTM@1239,4HKY4@91061,COG3290@1,COG3290@2 NA|NA|NA T GHKL domain HLLCKODE_01003 435842.HMPREF0848_00087 2e-132 478.4 Bacteria agrA ko:K07707 ko02020,ko02024,map02020,map02024 M00495 ko00000,ko00001,ko00002,ko02022 Bacteria COG3279@1,COG3279@2 NA|NA|NA KT phosphorelay signal transduction system HLLCKODE_01004 1046629.Ssal_01709 3.5e-205 720.7 Bacilli 3.4.17.14,3.5.1.28 ko:K01448,ko:K02395,ko:K07260 ko00550,ko01100,ko01502,ko01503,ko02020,map00550,map01100,map01502,map01503,map02020 M00651,M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504,ko02035,ko03036 Bacteria 1W25V@1239,4HGXW@91061,COG0860@1,COG0860@2,COG1705@1,COG1705@2 NA|NA|NA M GBS Bsp-like repeat HLLCKODE_01005 1167632.AJTR01000114_gene2106 5.2e-94 352.4 Bacteria bipA GO:0005575,GO:0005623,GO:0030115,GO:0030312,GO:0044464,GO:0071944 ko:K00666,ko:K03561,ko:K14645 ko02024,map02024 ko00000,ko00001,ko01000,ko01002,ko01004,ko02000,ko03110 1.A.30.2.1 Bacteria COG2911@1,COG2911@2,COG3266@1,COG3266@2,COG4372@1,COG4372@2 NA|NA|NA Q Transposase HLLCKODE_01006 264199.stu1045 8.1e-86 323.6 Firmicutes Bacteria 1TQ93@1239,COG3464@1,COG3464@2 NA|NA|NA L Transposase HLLCKODE_01007 1046629.Ssal_00673 0.0 3055.4 Bacilli zmpB GO:0005575,GO:0005618,GO:0005623,GO:0009986,GO:0016020,GO:0030312,GO:0044464,GO:0071944 ko:K08643 ko00000,ko01000,ko01002 Bacteria 1TRAR@1239,4HEH7@91061,COG3064@1,COG3064@2,COG3583@1,COG3583@2 NA|NA|NA M signal peptide protein, YSIRK family HLLCKODE_01008 1046629.Ssal_00675 0.0 1451.4 Bacteria Bacteria COG3266@1,COG3266@2 NA|NA|NA GM domain, Protein HLLCKODE_01009 1095738.HMPREF1047_1139 4.9e-54 219.9 Streptococcus oralis Bacteria 1UN93@1239,1WQ05@1303,29YAF@1,30K4J@2,4IU86@91061 NA|NA|NA HLLCKODE_01010 264199.stu1395 1.8e-218 765.0 Bacilli sbcD ko:K03547 ko00000,ko03400 Bacteria 1TQY6@1239,4HAKB@91061,COG0420@1,COG0420@2 NA|NA|NA L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity HLLCKODE_01011 1419814.V470_02690 0.0 1444.1 Bacilli sbcC ko:K03546 ko00000,ko03400 Bacteria 1TPCS@1239,4H9Q3@91061,COG0419@1,COG0419@2 NA|NA|NA L ATPase involved in DNA repair HLLCKODE_01012 706433.HMPREF9430_01341 8.5e-143 513.8 Firmicutes Bacteria 1V146@1239,28ITE@1,2Z8SB@2 NA|NA|NA HLLCKODE_01013 706433.HMPREF9430_01342 1.9e-36 160.2 Erysipelotrichia ko:K06940,ko:K18475 ko00000,ko01000,ko02035 Bacteria 1TUXJ@1239,3VU24@526524,COG0727@1,COG0727@2 NA|NA|NA S PFAM Uncharacterised protein family (UPF0153) HLLCKODE_01014 1046629.Ssal_00976 2.1e-288 997.7 Bacilli adcA GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0007154,GO:0008150,GO:0008270,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010035,GO:0010038,GO:0030288,GO:0030313,GO:0031667,GO:0031668,GO:0031669,GO:0031975,GO:0033554,GO:0034224,GO:0042221,GO:0042594,GO:0042597,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046686,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0120127 ko:K09815 ko02010,map02010 M00242 ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 Bacteria 1TPG7@1239,4H9UN@91061,COG0803@1,COG0803@2,COG3443@1,COG3443@2 NA|NA|NA P Belongs to the bacterial solute-binding protein 9 family HLLCKODE_01015 1046629.Ssal_00975 8.2e-143 513.1 Bacteria XK27_10720 Bacteria COG2339@1,COG2339@2 NA|NA|NA D peptidase activity HLLCKODE_01016 1046629.Ssal_00974 1.5e-274 951.4 Bacilli pepD ko:K08659 ko00000,ko01000,ko01002 Bacteria 1TQ0F@1239,4HC3G@91061,COG4690@1,COG4690@2 NA|NA|NA E Dipeptidase HLLCKODE_01017 1046629.Ssal_00973 5.7e-161 573.5 Bacilli whiA GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0043937,GO:0044464,GO:0050789,GO:0050793,GO:0065007,GO:0071944 ko:K09762 ko00000 Bacteria 1TP2X@1239,4HB4H@91061,COG1481@1,COG1481@2 NA|NA|NA K May be required for sporulation HLLCKODE_01018 1046629.Ssal_00972 1.8e-181 641.7 Bacilli ybhK Bacteria 1TPNV@1239,4HA0Z@91061,COG0391@1,COG0391@2 NA|NA|NA S Required for morphogenesis under gluconeogenic growth conditions HLLCKODE_01019 1046629.Ssal_00971 5.5e-161 573.5 Bacilli rapZ GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363 ko:K06958 ko00000,ko03019 Bacteria 1TPS4@1239,4H9KM@91061,COG1660@1,COG1660@2 NA|NA|NA S Displays ATPase and GTPase activities HLLCKODE_01020 1046629.Ssal_00970 2.9e-134 484.6 Bacilli yejC Bacteria 1V46X@1239,4HI49@91061,COG4420@1,COG4420@2 NA|NA|NA S cyclic nucleotide-binding protein HLLCKODE_01021 1046629.Ssal_00969 5.2e-202 711.1 Bacteria Bacteria COG1196@1,COG1196@2 NA|NA|NA D nuclear chromosome segregation HLLCKODE_01022 904306.HMPREF9192_1256 1.4e-94 352.1 Bacilli queF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016651,GO:0016657,GO:0018130,GO:0019438,GO:0033739,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.7.1.13 ko:K06879,ko:K09457 ko00790,ko01100,map00790,map01100 R07605 RC01875 ko00000,ko00001,ko01000,ko03016 iSFV_1184.SFV_2663,iSF_1195.SF2807,iS_1188.S3002 Bacteria 1TPYC@1239,4HB14@91061,COG0780@1,COG0780@2 NA|NA|NA S Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily HLLCKODE_01023 904306.HMPREF9192_1255 7.2e-135 486.5 Bacilli queE GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008144,GO:0016829,GO:0016840,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:1901681,GO:1904047 1.97.1.4,4.3.99.3 ko:K04068,ko:K10026 ko00790,ko01100,map00790,map01100 R04710,R10002 RC02989 ko00000,ko00001,ko01000,ko03016 Bacteria 1TQ58@1239,4HAJ3@91061,COG0602@1,COG0602@2 NA|NA|NA H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds HLLCKODE_01024 1046629.Ssal_00964 6.9e-80 303.1 Bacilli queD 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 Bacteria 1V9HU@1239,4HJEX@91061,COG0720@1,COG0720@2 NA|NA|NA H synthase HLLCKODE_01025 1046629.Ssal_00963 2.6e-123 448.0 Bacilli queC 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 R09978 RC00959 ko00000,ko00001,ko01000,ko03016 Bacteria 1TP4Z@1239,4HB1Y@91061,COG0603@1,COG0603@2 NA|NA|NA F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) HLLCKODE_01026 1046629.Ssal_00962 2.3e-63 248.1 Bacilli tdcF 3.5.99.10 ko:K09022 R11098,R11099 RC03275,RC03354 ko00000,ko01000 Bacteria 1V6HG@1239,4HKEF@91061,COG0251@1,COG0251@2 NA|NA|NA J endoribonuclease L-PSP HLLCKODE_01027 888833.HMPREF9421_1356 8.1e-200 703.0 Bacilli pmrB Bacteria 1V6VB@1239,4IT0A@91061,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily HLLCKODE_01028 562983.HMPREF0433_01645 4.8e-19 100.9 Bacilli Bacteria 1W2BC@1239,2DF7W@1,2ZQU2@2,4HZFK@91061 NA|NA|NA HLLCKODE_01029 904306.HMPREF9192_1250 9.3e-261 905.6 Bacilli asnS GO:0003674,GO:0003824,GO:0004812,GO:0004816,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006421,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.22 ko:K01893 ko00970,map00970 M00359,M00360 R03648 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1TP38@1239,4H9YH@91061,COG0017@1,COG0017@2 NA|NA|NA J Catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA HLLCKODE_01030 264199.stu0817 3.7e-213 747.3 Bacilli aspB GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769,GO:0047297 2.6.1.1,2.6.1.14 ko:K00812,ko:K22457 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 R00355,R00694,R00734,R00896,R01346,R02433,R02619,R05052 RC00006,RC00025 ko00000,ko00001,ko01000,ko01007 iHN637.CLJU_RS06550 Bacteria 1TP0J@1239,4HA13@91061,COG0436@1,COG0436@2 NA|NA|NA E Aminotransferase HLLCKODE_01031 1046629.Ssal_00958 3e-76 291.2 Bacilli ypmB Bacteria 1VA2H@1239,4HNMM@91061,COG5353@1,COG5353@2 NA|NA|NA S Protein conserved in bacteria HLLCKODE_01032 1046629.Ssal_00957 0.0 1550.8 Bacilli dinG GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7,3.6.4.12 ko:K02342,ko:K03722 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 1TQHQ@1239,4HB2Y@91061,COG1199@1,COG1199@2,COG2176@1,COG2176@2 NA|NA|NA L helicase involved in DNA repair and perhaps also replication HLLCKODE_01033 1046629.Ssal_00954 9.8e-112 409.5 Bacilli ycbL GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019243,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0051596,GO:0061727,GO:0071704,GO:1901575,GO:1901615 3.1.2.6 ko:K01069 ko00620,map00620 R01736 RC00004,RC00137 ko00000,ko00001,ko01000 Bacteria 1V6FA@1239,4HHRQ@91061,COG0491@1,COG0491@2 NA|NA|NA S COG0491 Zn-dependent hydrolases, including glyoxylases HLLCKODE_01034 1046629.Ssal_00206 2.4e-225 787.7 Bacilli tgt GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 ko:K00773 R03789,R10209 RC00063 ko00000,ko01000,ko03016 Bacteria 1TNZ4@1239,4HCNM@91061,COG0343@1,COG0343@2 NA|NA|NA F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) HLLCKODE_01035 1123299.AUKZ01000036_gene1534 3.4e-14 83.2 Bacteria rpmH GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02914 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria COG0230@1,COG0230@2 NA|NA|NA J Ribosomal protein L34 HLLCKODE_01036 1046629.Ssal_00204 1.2e-97 362.5 Bacilli 1.6.5.2 ko:K00355 ko00130,ko01110,ko05200,ko05225,ko05418,map00130,map01110,map05200,map05225,map05418 R02964,R03643,R03816 RC00819 ko00000,ko00001,ko01000 Bacteria 1V59U@1239,4HHZC@91061,COG2249@1,COG2249@2 NA|NA|NA S NADPH-quinone reductase (modulator of drug activity B) HLLCKODE_01037 1046629.Ssal_00203 4e-99 367.5 Bacilli Bacteria 1V0VT@1239,4HPD3@91061,COG1309@1,COG1309@2 NA|NA|NA K Transcriptional regulator HLLCKODE_01038 1046629.Ssal_00202 3.4e-170 604.4 Bacilli jag ko:K06346 ko00000 Bacteria 1V3IN@1239,4HHHU@91061,COG1847@1,COG1847@2 NA|NA|NA S RNA-binding protein HLLCKODE_01039 1046629.Ssal_00201 9.2e-139 499.6 Bacilli yidC ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 Bacteria 1TQ0J@1239,4HB3J@91061,COG0706@1,COG0706@2 NA|NA|NA U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HLLCKODE_01040 264199.stu1811 3.5e-52 210.7 Bacilli rnpA GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031123,GO:0031404,GO:0031974,GO:0031981,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043628,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904 3.1.26.5 ko:K03536,ko:K08998 ko00000,ko01000,ko03016 Bacteria 1VA78@1239,4HKG6@91061,COG0594@1,COG0594@2 NA|NA|NA J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme HLLCKODE_01041 1046629.Ssal_00199 4.6e-263 913.3 Bacilli argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1TNZ6@1239,4HB24@91061,COG0165@1,COG0165@2 NA|NA|NA E Argininosuccinate lyase HLLCKODE_01042 1046629.Ssal_00198 1.7e-229 801.6 Bacilli argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 iJN678.argG,iSB619.SA_RS04675 Bacteria 1TP3X@1239,4HA1E@91061,COG0137@1,COG0137@2 NA|NA|NA E Belongs to the argininosuccinate synthase family. Type 1 subfamily HLLCKODE_01043 435842.HMPREF0848_01858 7.2e-130 469.9 Bacilli fasA ko:K07707 ko02020,ko02024,map02020,map02024 M00495 ko00000,ko00001,ko00002,ko02022 Bacteria 1V392@1239,4HHAI@91061,COG3279@1,COG3279@2 NA|NA|NA KT Response regulator of the LytR AlgR family HLLCKODE_01044 435842.HMPREF0848_01857 5.2e-224 783.5 Bacteria fasC Bacteria COG3290@1,COG3290@2 NA|NA|NA T protein histidine kinase activity HLLCKODE_01045 435842.HMPREF0848_01856 2.3e-208 731.5 Bacteria hpk9 2.7.13.3 ko:K07706 ko02020,ko02024,map02020,map02024 M00495 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria COG3290@1,COG3290@2 NA|NA|NA T protein histidine kinase activity HLLCKODE_01046 1046629.Ssal_00193 9.5e-153 546.2 Bacteria hpk9 2.7.13.3 ko:K07706 ko02020,ko02024,map02020,map02024 M00495 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria COG3290@1,COG3290@2 NA|NA|NA T protein histidine kinase activity HLLCKODE_01047 1046629.Ssal_00192 9.1e-229 799.3 Bacilli 2.7.13.3 ko:K07706 ko02020,ko02024,map02020,map02024 M00495 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1UYTM@1239,4IPJ9@91061,COG3290@1,COG3290@2 NA|NA|NA T signal transduction protein with a C-terminal ATPase domain HLLCKODE_01048 904306.HMPREF9192_2057 8.7e-281 972.2 Bacilli gltX GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009986,GO:0030246,GO:0030247,GO:0044424,GO:0044464,GO:2001065 6.1.1.17,6.1.1.24 ko:K01885,ko:K09698 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R03651,R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 iSB619.SA_RS02860 Bacteria 1TPJC@1239,4HAKH@91061,COG0008@1,COG0008@2 NA|NA|NA J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) HLLCKODE_01049 1046629.Ssal_00190 0.0 1265.4 Bacilli amiA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 1TQVS@1239,4HCCB@91061,COG4166@1,COG4166@2 NA|NA|NA E ABC transporter, substrate-binding protein, family 5 HLLCKODE_01050 1046629.Ssal_00189 5.3e-119 433.7 Bacilli rplA GO:0000027,GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006417,GO:0006446,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0017148,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045947,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02863 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1TPTS@1239,4HAK4@91061,COG0081@1,COG0081@2 NA|NA|NA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release HLLCKODE_01051 1046629.Ssal_00188 3.7e-70 270.8 Bacilli rplK GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010467,GO:0015934,GO:0015968,GO:0016043,GO:0019538,GO:0019843,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0032984,GO:0032991,GO:0033554,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0042594,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0051716,GO:0065003,GO:0070925,GO:0071496,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02867 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V1BS@1239,4HFQ0@91061,COG0080@1,COG0080@2 NA|NA|NA J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors HLLCKODE_01052 1046629.Ssal_00187 1.2e-50 205.7 Firmicutes Bacteria 1VNK9@1239,2DSU9@1,33HF9@2 NA|NA|NA S Protein of unknown function (DUF3397) HLLCKODE_01053 1046629.Ssal_00186 5e-87 327.0 Bacilli cah 4.2.1.1 ko:K01673 ko00910,map00910 R00132,R10092 RC02807 ko00000,ko00001,ko01000 Bacteria 1V0TA@1239,4HB9V@91061,COG0288@1,COG0288@2 NA|NA|NA P Reversible hydration of carbon dioxide HLLCKODE_01054 1046629.Ssal_00185 1.6e-126 458.8 Bacilli WQ51_05710 Bacteria 1V6BD@1239,4HIAR@91061,COG2013@1,COG2013@2 NA|NA|NA S Mitochondrial biogenesis AIM24 HLLCKODE_01055 1046629.Ssal_00184 1.5e-225 788.5 Bacilli radA ko:K04485 ko00000,ko03400 Bacteria 1TQ7Y@1239,4H9YC@91061,COG1066@1,COG1066@2 NA|NA|NA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function HLLCKODE_01056 1095738.HMPREF1047_1312 1.7e-76 292.0 Bacteria 3.5.1.19 ko:K08281 ko00760,ko01100,map00760,map01100 R01268 RC00100 ko00000,ko00001,ko01000 Bacteria COG1335@1,COG1335@2 NA|NA|NA Q hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides HLLCKODE_01057 264199.stu1824 3.2e-77 294.3 Bacilli dut GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23,4.1.1.36,6.3.2.5 ko:K01520,ko:K13038 ko00240,ko00770,ko00983,ko01100,map00240,map00770,map00983,map01100 M00053,M00120 R02100,R03269,R04231,R11896 RC00002,RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000,ko03400 Bacteria 1V6HX@1239,4HIZ3@91061,COG0756@1,COG0756@2 NA|NA|NA F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA HLLCKODE_01058 1046629.Ssal_00181 1.4e-107 395.6 Bacteria XK27_09620 Bacteria COG0431@1,COG0431@2 NA|NA|NA S FMN reductase (NADPH) activity HLLCKODE_01059 904306.HMPREF9192_2046 7.9e-230 802.7 Bacilli XK27_09615 Bacteria 1TPRA@1239,4HDA5@91061,COG0431@1,COG0431@2,COG2461@1,COG2461@2 NA|NA|NA C reductase HLLCKODE_01060 1046629.Ssal_00179 9.6e-141 506.1 Bacilli fnt ko:K06212,ko:K21993 ko00000,ko02000 1.A.16.1.1,1.A.16.1.3,1.A.16.2 Bacteria 1V164@1239,4HFJC@91061,COG2116@1,COG2116@2 NA|NA|NA P Formate nitrite transporter HLLCKODE_01061 1046629.Ssal_00177 1.9e-95 355.1 Bacteria XK27_08585 ko:K16926 M00582 ko00000,ko00002,ko02000 3.A.1.31 Bacteria 2BY0N@1,321KG@2 NA|NA|NA S Psort location CytoplasmicMembrane, score HLLCKODE_01062 1046629.Ssal_00176 2.4e-184 651.4 Bacilli gpsA GO:0003674,GO:0003824,GO:0004367,GO:0006072,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0046167,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901576 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 R00842,R00844 RC00029 ko00000,ko00001,ko01000 Bacteria 1TQ5P@1239,4HAXW@91061,COG0240@1,COG0240@2 NA|NA|NA I Glycerol-3-phosphate dehydrogenase HLLCKODE_01063 904306.HMPREF9192_2041 1.6e-168 598.6 Bacilli galU 2.7.7.9 ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 M00129,M00361,M00362,M00549 R00289 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQ24@1239,4HATY@91061,COG1210@1,COG1210@2 NA|NA|NA M UTP-glucose-1-phosphate uridylyltransferase HLLCKODE_01064 904306.HMPREF9192_2040 1.1e-116 426.0 Bacilli gluP 3.4.21.105 ko:K19225 ko00000,ko01000,ko01002 Bacteria 1TQXT@1239,4HCDF@91061,COG0705@1,COG0705@2 NA|NA|NA O membrane protein (homolog of Drosophila rhomboid) HLLCKODE_01065 904306.HMPREF9192_2039 2.9e-93 347.8 Bacilli ygfA GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0022611,GO:0030272,GO:0032502,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 R02301 RC00183 ko00000,ko00001,ko01000 iECABU_c1320.ECABU_c31940,iECOK1_1307.ECOK1_3298,iECSF_1327.ECSF_2705,iUTI89_1310.UTI89_C3298 Bacteria 1VA91@1239,4HM35@91061,COG0212@1,COG0212@2 NA|NA|NA H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family HLLCKODE_01066 1046629.Ssal_00172 7.4e-219 766.1 Bacilli hipO GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0050118,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.1.47 ko:K05823,ko:K21613 ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230 M00525 R02733 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000,ko01002 Bacteria 1TPD7@1239,4H9SG@91061,COG1473@1,COG1473@2 NA|NA|NA E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate HLLCKODE_01067 1046629.Ssal_00170 5.3e-58 231.1 Bacilli dapD GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008666,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016749,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.117,2.3.1.89 ko:K00674,ko:K05822 ko00300,ko01100,ko01110,ko01120,ko01230,map00300,map01100,map01110,map01120,map01230 M00016,M00525 R04364,R04365 RC00004,RC01136 ko00000,ko00001,ko00002,ko01000 iSbBS512_1146.SbBS512_E0158,iYO844.BSU14180 Bacteria 1TQUJ@1239,4H9KY@91061,COG2171@1,COG2171@2 NA|NA|NA E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate HLLCKODE_01068 904306.HMPREF9192_2036 1.3e-126 459.1 Bacilli ko:K07025 ko00000 Bacteria 1V73N@1239,4IU82@91061,COG0546@1,COG0546@2 NA|NA|NA S HAD hydrolase, family IA, variant HLLCKODE_01069 904306.HMPREF9192_2035 2.3e-156 558.1 Bacteria rrmA 2.1.1.187 ko:K00563,ko:K10947 R07233 RC00003 ko00000,ko01000,ko03000,ko03009 Bacteria COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase HLLCKODE_01072 1046629.Ssal_00164 7.3e-89 333.2 Bacilli tadA 3.5.4.1,3.5.4.33 ko:K01485,ko:K11991 ko00240,ko00330,ko01100,map00240,map00330,map01100 R00974,R01411,R02922,R10223 RC00074,RC00477,RC00514,RC00809 ko00000,ko00001,ko01000,ko03016 Bacteria 1V3HZ@1239,4HH7S@91061,COG0590@1,COG0590@2 NA|NA|NA FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) HLLCKODE_01073 322159.STER_1821 6.6e-66 256.5 Bacilli ssb_2 ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 ko00000,ko00001,ko03029,ko03032,ko03400 Bacteria 1VXMZ@1239,4HXCW@91061,COG0629@1,COG0629@2 NA|NA|NA L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism HLLCKODE_01074 322159.STER_1822 8.3e-37 159.1 Bacteria yeeD GO:0008150,GO:0009987,GO:0019725,GO:0042592,GO:0048878,GO:0055082,GO:0065007,GO:0065008 ko:K07112 ko00000 Bacteria COG0425@1,COG0425@2 NA|NA|NA O sulfur carrier activity HLLCKODE_01075 322159.STER_1823 3.3e-189 667.5 Bacilli yeeE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K07112 ko00000 Bacteria 1TSNG@1239,4HDN0@91061,COG2391@1,COG2391@2 NA|NA|NA S Sulphur transport HLLCKODE_01076 1046629.Ssal_00160 1.1e-112 412.5 Bacilli pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890,ko:K06878 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1V7QA@1239,4HJBD@91061,COG0073@1,COG0073@2 NA|NA|NA J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily HLLCKODE_01078 1046629.Ssal_00158 3.6e-54 217.2 Bacilli ytpP GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 2.7.1.180,5.3.4.1 ko:K01829,ko:K03671,ko:K03734,ko:K06196 ko04621,ko05418,map04621,map05418 ko00000,ko00001,ko01000,ko02000,ko03110 5.A.1.2 Bacteria 1VAS6@1239,4HKGM@91061,COG0526@1,COG0526@2 NA|NA|NA CO Thioredoxin HLLCKODE_01079 1214166.ALLG01000045_gene803 1.6e-08 65.5 Streptococcus suis XK27_10305 Bacteria 1U930@1239,1WTMK@1307,2BUTS@1,32Q5B@2,4IJ3P@91061 NA|NA|NA S Domain of unknown function (DUF4651) HLLCKODE_01080 1046629.Ssal_00156 1.8e-203 714.9 Bacilli pepA 3.4.11.7 ko:K01261,ko:K01269 ko00000,ko01000,ko01002 Bacteria 1TNZT@1239,4H9SM@91061,COG1363@1,COG1363@2 NA|NA|NA G COG1363 Cellulase M and related proteins HLLCKODE_01081 904306.HMPREF9192_2022 2.8e-129 468.0 Bacilli proC 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP1E@1239,4HCBY@91061,COG0345@1,COG0345@2 NA|NA|NA E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline HLLCKODE_01082 264199.stu1853 1.3e-93 349.4 Bacilli ko:K07052 ko00000 Bacteria 1VEE2@1239,4HP4A@91061,COG1266@1,COG1266@2 NA|NA|NA S CAAX amino terminal protease family protein HLLCKODE_01084 1046629.Ssal_00152 5.4e-105 387.1 Bacteria ko:K07052 ko00000 Bacteria COG1266@1,COG1266@2 NA|NA|NA V CAAX protease self-immunity HLLCKODE_01085 1046629.Ssal_00151 8.8e-27 125.6 Bacteria lanR ko:K07729 ko00000,ko03000 Bacteria COG1476@1,COG1476@2 NA|NA|NA K sequence-specific DNA binding HLLCKODE_01086 904306.HMPREF9192_2018 2.9e-221 774.2 Bacilli ackA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv0409 Bacteria 1TQ22@1239,4HA7K@91061,COG0282@1,COG0282@2 NA|NA|NA F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction HLLCKODE_01087 904306.HMPREF9192_2017 1.5e-175 622.1 Bacilli ytxK 2.1.1.72 ko:K00571 ko00000,ko01000,ko02048 Bacteria 1TRIQ@1239,4H9SE@91061,COG0827@1,COG0827@2 NA|NA|NA L DNA methylase HLLCKODE_01088 1198676.SMUGS5_08910 1.2e-12 79.3 Bacilli comGF ko:K02246,ko:K02248 M00429 ko00000,ko00002,ko02044 Bacteria 1VJKM@1239,4HQDT@91061,COG4940@1,COG4940@2 NA|NA|NA U Putative Competence protein ComGF HLLCKODE_01089 1046629.Ssal_00147 4.9e-70 270.4 Bacilli comGF ko:K02246,ko:K02248 M00429 ko00000,ko00002,ko02044 Bacteria 1VKRP@1239,4HR6S@91061,COG4940@1,COG4940@2 NA|NA|NA U Competence protein ComGF HLLCKODE_01090 873449.STRCR_0577 1.7e-16 91.7 Firmicutes Bacteria 1W385@1239,2ZS6J@2,COG2165@1 NA|NA|NA NU Type II secretory pathway pseudopilin HLLCKODE_01091 904306.HMPREF9192_2013 2.3e-67 261.5 Bacilli cglD ko:K02246 M00429 ko00000,ko00002,ko02044 Bacteria 1VPGT@1239,33A38@2,4HRZ0@91061,COG2165@1 NA|NA|NA NU Competence protein HLLCKODE_01092 1046629.Ssal_00144 2.2e-43 181.4 Bacilli comGC GO:0005575,GO:0005623,GO:0005886,GO:0009986,GO:0016020,GO:0044464,GO:0071944 ko:K02245,ko:K02456 ko03070,ko05111,map03070,map05111 M00331,M00429 ko00000,ko00001,ko00002,ko02044 3.A.15 Bacteria 1VFI9@1239,4HNNT@91061,COG4537@1,COG4537@2 NA|NA|NA U Required for transformation and DNA binding HLLCKODE_01093 904306.HMPREF9192_2011 4.8e-143 513.8 Bacilli comGA ko:K02243,ko:K02244 M00429 ko00000,ko00002,ko02044 3.A.14.1 Bacteria 1TPGE@1239,4HB0C@91061,COG1459@1,COG1459@2,COG2804@1,COG2804@2 NA|NA|NA NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB HLLCKODE_01094 1046629.Ssal_00142 1.6e-174 618.6 Bacilli comGA ko:K02243 M00429 ko00000,ko00002,ko02044 3.A.14.1 Bacteria 1TPGE@1239,4HB0C@91061,COG2804@1,COG2804@2 NA|NA|NA NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB HLLCKODE_01095 1046629.Ssal_00141 2.9e-68 264.2 Bacilli Bacteria 1VHC7@1239,4HS15@91061,COG4699@1,COG4699@2 NA|NA|NA S cog cog4699 HLLCKODE_01096 904306.HMPREF9192_2007 0.0 2378.2 Bacilli rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 1TNYT@1239,4HA24@91061,COG0086@1,COG0086@2 NA|NA|NA K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates HLLCKODE_01097 1046629.Ssal_00138 0.0 2298.5 Bacilli rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 1TP96@1239,4H9PK@91061,COG0085@1,COG0085@2 NA|NA|NA K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates HLLCKODE_01098 1046629.Ssal_00136 0.0 1538.9 Bacilli pbp1B 2.4.1.129,3.4.16.4 ko:K03693,ko:K05365,ko:K05366,ko:K05367,ko:K12551,ko:K12555,ko:K21464 ko00550,ko01100,ko01501,map00550,map01100,map01501 R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 GT51 Bacteria 1TPM5@1239,4H9SA@91061,COG0744@1,COG0744@2 NA|NA|NA M penicillin-binding protein HLLCKODE_01099 904306.HMPREF9192_2004 5.5e-239 833.2 Bacilli tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006437,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 iAF1260.b1637,iBWG_1329.BWG_1452,iECDH10B_1368.ECDH10B_1771,iECDH1ME8569_1439.ECDH1ME8569_1581,iECH74115_1262.ECH74115_2349,iECIAI39_1322.ECIAI39_1418,iECNA114_1301.ECNA114_1685,iECO103_1326.ECO103_1778,iECO111_1330.ECO111_2107,iECO26_1355.ECO26_2366,iECSE_1348.ECSE_1760,iECSF_1327.ECSF_1500,iECSP_1301.ECSP_2202,iECUMN_1333.ECUMN_1928,iECW_1372.ECW_m1805,iECs_1301.ECs2346,iEKO11_1354.EKO11_2137,iETEC_1333.ETEC_1672,iEcDH1_1363.EcDH1_2003,iEcE24377_1341.EcE24377A_1847,iEcHS_1320.EcHS_A1713,iEcSMS35_1347.EcSMS35_1562,iEcolC_1368.EcolC_1992,iJO1366.b1637,iSFV_1184.SFV_1654,iSF_1195.SF1662,iSSON_1240.SSON_1519,iSbBS512_1146.SbBS512_E1829,iUMNK88_1353.UMNK88_2097,iWFL_1372.ECW_m1805,iY75_1357.Y75_RS08585 Bacteria 1TPGN@1239,4H9YV@91061,COG0162@1,COG0162@2 NA|NA|NA J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) HLLCKODE_01100 322159.STER_1848 1.3e-193 682.2 Bacilli ilvC 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPI7@1239,4HADK@91061,COG0059@1,COG0059@2 NA|NA|NA H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate HLLCKODE_01101 904306.HMPREF9192_2002 5e-76 290.4 Bacilli ilvN GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 ko:K01653,ko:K16785 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230,map02010 M00019,M00570,M00582 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 Bacteria 1V2AJ@1239,4HDY5@91061,COG0440@1,COG0440@2 NA|NA|NA E Acetolactate synthase HLLCKODE_01102 1046629.Ssal_00132 0.0 1104.7 Bacilli ilvB 2.2.1.6 ko:K01652,ko:K16787 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230,map02010 M00019,M00570,M00582 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 iYO844.BSU28310 Bacteria 1TQE8@1239,4H9VR@91061,COG0028@1,COG0028@2 NA|NA|NA EH Acetolactate synthase HLLCKODE_01103 1046629.Ssal_00131 0.0 1130.9 Bacilli ilvD 4.2.1.9 ko:K01687,ko:K16786 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00770,map01100,map01110,map01130,map01210,map01230,map02010 M00019,M00570,M00582 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 iAF987.Gmet_1259 Bacteria 1TP1R@1239,4H9ZG@91061,COG0129@1,COG0129@2 NA|NA|NA E Belongs to the IlvD Edd family HLLCKODE_01104 1046629.Ssal_00130 7.1e-303 1045.8 Bacilli yloV ko:K07030 ko00000 Bacteria 1TQMX@1239,4HBSE@91061,COG1461@1,COG1461@2 NA|NA|NA S kinase related to dihydroxyacetone kinase HLLCKODE_01105 1046629.Ssal_00129 1.4e-57 228.8 Bacilli asp Bacteria 1V3Q6@1239,4HHYJ@91061,COG1302@1,COG1302@2 NA|NA|NA S cog cog1302 HLLCKODE_01106 1046629.Ssal_00128 5.1e-224 783.5 Bacilli norN ko:K03327 ko00000,ko02000 2.A.66.1 Bacteria 1TQMT@1239,4H9Y2@91061,COG0534@1,COG0534@2 NA|NA|NA V Mate efflux family protein HLLCKODE_01107 1046629.Ssal_00127 1.9e-275 954.5 Bacilli thrC 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS16355,iIT341.HP0098 Bacteria 1TPR0@1239,4H9R7@91061,COG0498@1,COG0498@2 NA|NA|NA E Threonine synthase HLLCKODE_01110 904306.HMPREF9192_1994 0.0 1677.1 Bacilli adhE 1.1.1.1,1.2.1.10 ko:K04072 ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220 R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927 RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195 ko00000,ko00001,ko01000 iSB619.SA_RS00885 Bacteria 1TPB4@1239,4HAN8@91061,COG1012@1,COG1012@2,COG1454@1,COG1454@2 NA|NA|NA C belongs to the iron- containing alcohol dehydrogenase family HLLCKODE_01111 435842.HMPREF0848_01786 0.0 1258.4 Bacilli pepO 3.4.24.71 ko:K01415,ko:K07386 ko00000,ko01000,ko01002,ko04147 Bacteria 1TQTA@1239,4HDSF@91061,COG3590@1,COG3590@2 NA|NA|NA O Peptidase family M13 HLLCKODE_01112 1046629.Ssal_00120 6.9e-63 246.5 Bacilli treC GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005991,GO:0005993,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008788,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0015927,GO:0016052,GO:0016787,GO:0016798,GO:0033554,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046352,GO:0050896,GO:0051716,GO:0071704,GO:1901575 3.2.1.93 ko:K01226 ko00500,map00500 R00837,R06113 RC00049 ko00000,ko00001,ko01000 GH13 iECW_1372.ECW_m4600,iEKO11_1354.EKO11_4072,iEcE24377_1341.EcE24377A_4811,iEcSMS35_1347.EcSMS35_4720,iWFL_1372.ECW_m4600 Bacteria 1TP53@1239,4HA1G@91061,COG0366@1,COG0366@2 NA|NA|NA G COG0366 Glycosidases HLLCKODE_01113 1046629.Ssal_00118 6e-126 456.8 Bacilli treR ko:K03486,ko:K03710 ko00000,ko03000 Bacteria 1TRF6@1239,4HDCX@91061,COG2188@1,COG2188@2 NA|NA|NA K trehalose operon HLLCKODE_01114 1046629.Ssal_00117 5.1e-96 357.1 Bacilli ywlG Bacteria 1V3H0@1239,4HH6F@91061,COG4475@1,COG4475@2 NA|NA|NA S Belongs to the UPF0340 family HLLCKODE_01117 1046629.Ssal_00114 1.3e-165 589.0 Bacilli fba 4.1.2.13,4.1.2.29 ko:K01624,ko:K03339 ko00010,ko00030,ko00051,ko00562,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00562,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568,R05378 RC00438,RC00439,RC00603,RC00604,RC00721 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQ01@1239,4H9ZU@91061,COG0191@1,COG0191@2 NA|NA|NA G aldolase HLLCKODE_01119 1046629.Ssal_00112 1.6e-246 858.2 Bacilli 6.3.2.2 ko:K01919,ko:K06048 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 Bacteria 1TW3D@1239,4HTV4@91061,COG3572@1,COG3572@2 NA|NA|NA H gamma-glutamylcysteine synthetase HLLCKODE_01120 322159.STER_0151 6.5e-224 783.1 Firmicutes ko:K07485 ko00000 Bacteria 1TQ93@1239,COG3464@1,COG3464@2 NA|NA|NA L Transposase HLLCKODE_01121 1046629.Ssal_00111 4.4e-62 243.8 Bacilli rplQ GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02879,ko:K16193 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V6JQ@1239,4HGX2@91061,COG0203@1,COG0203@2 NA|NA|NA J ribosomal protein l17 HLLCKODE_01122 1046629.Ssal_00110 3.6e-171 607.4 Bacilli rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 1TPR8@1239,4H9R1@91061,COG0202@1,COG0202@2 NA|NA|NA K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates HLLCKODE_01123 1046629.Ssal_00109 1.9e-62 245.0 Bacilli rpsK GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02948 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V3IK@1239,4HH2T@91061,COG0100@1,COG0100@2 NA|NA|NA J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome HLLCKODE_01124 1046629.Ssal_00108 4e-57 227.3 Bacilli rpsM GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02952 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V3JH@1239,4HGX6@91061,COG0099@1,COG0099@2 NA|NA|NA J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HLLCKODE_01125 1123301.KB904201_gene1724 6e-15 85.5 Bacteria rpmJ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02919 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria COG0257@1,COG0257@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL36 family HLLCKODE_01126 1123298.KB904065_gene2021 2.7e-32 144.1 Bacilli infA GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009986,GO:0016020,GO:0030246,GO:0030247,GO:0030312,GO:0040007,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071944,GO:2001065 ko:K02518 ko00000,ko03012 Bacteria 1V9ZK@1239,4HKF4@91061,COG0361@1,COG0361@2 NA|NA|NA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex HLLCKODE_01127 904306.HMPREF9192_1977 2.1e-114 418.3 Bacilli adk GO:0003674,GO:0003824,GO:0004017,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 iHN637.CLJU_RS20110 Bacteria 1TP27@1239,4HA89@91061,COG0563@1,COG0563@2 NA|NA|NA F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism HLLCKODE_01128 1046629.Ssal_00104 6.2e-230 803.1 Bacilli secY GO:0002790,GO:0003674,GO:0005048,GO:0005215,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0034613,GO:0040007,GO:0042277,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5 Bacteria 1TPHB@1239,4HAWH@91061,COG0201@1,COG0201@2 NA|NA|NA U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently HLLCKODE_01129 1046629.Ssal_00103 5.7e-58 230.3 Bacilli rplO GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02876 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V3KE@1239,4HFPW@91061,COG0200@1,COG0200@2 NA|NA|NA J binds to the 23S rRNA HLLCKODE_01130 1046629.Ssal_00102 1.9e-23 114.4 Bacilli rpmD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 ko:K02907 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1VEG4@1239,4HNHF@91061,COG1841@1,COG1841@2 NA|NA|NA J ribosomal protein l30 HLLCKODE_01131 1046629.Ssal_00101 1.3e-79 302.4 Bacilli rpsE GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990145,GO:1990904 ko:K02988 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V1B1@1239,4HFN4@91061,COG0098@1,COG0098@2 NA|NA|NA J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body HLLCKODE_01132 435842.HMPREF0848_01767 1.9e-56 224.9 Bacilli rplR GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02881 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V6DM@1239,4HIGF@91061,COG0256@1,COG0256@2 NA|NA|NA J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance HLLCKODE_01133 1046629.Ssal_00099 1.1e-92 345.9 Bacilli rplF GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02933 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V1FC@1239,4HFQD@91061,COG0097@1,COG0097@2 NA|NA|NA J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center HLLCKODE_01134 1046629.Ssal_00098 1.2e-67 262.3 Bacilli rpsH GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009894,GO:0009987,GO:0010467,GO:0010468,GO:0010608,GO:0015935,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031323,GO:0031329,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043487,GO:0043488,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0061013,GO:0065003,GO:0065007,GO:0065008,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903311,GO:1990904 ko:K02994 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V3KK@1239,4HH32@91061,COG0096@1,COG0096@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit HLLCKODE_01135 1000570.HMPREF9966_1576 1.5e-28 131.3 Streptococcus anginosus group rpsN GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02954 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1VEF6@1239,42EG0@671232,4HNKX@91061,COG0199@1,COG0199@2 NA|NA|NA J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site HLLCKODE_01136 1046629.Ssal_00096 1.6e-94 352.1 Bacilli rplE GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02931 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1TPE0@1239,4HBAX@91061,COG0094@1,COG0094@2 NA|NA|NA J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HLLCKODE_01137 1046629.Ssal_00095 1.4e-47 195.3 Bacilli rplX GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02895 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V9ZQ@1239,4HKH9@91061,COG0198@1,COG0198@2 NA|NA|NA J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit HLLCKODE_01138 1046629.Ssal_00094 3.9e-60 237.3 Bacilli rplN GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02874 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V3N0@1239,4HGYR@91061,COG0093@1,COG0093@2 NA|NA|NA J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome HLLCKODE_01139 1046629.Ssal_00093 6e-39 166.4 Bacilli rpsQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02961 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V9YC@1239,4HKDN@91061,COG0186@1,COG0186@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA HLLCKODE_01140 1046629.Ssal_00092 3.5e-26 123.6 Bacilli rpmC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02904 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1VEME@1239,4HNUP@91061,COG0255@1,COG0255@2 NA|NA|NA J Belongs to the universal ribosomal protein uL29 family HLLCKODE_01141 1046629.Ssal_00091 1.1e-71 275.8 Bacilli rplP GO:0000027,GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02878 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V1AY@1239,4HFPN@91061,COG0197@1,COG0197@2 NA|NA|NA J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs HLLCKODE_01142 1046629.Ssal_00090 1.6e-117 428.7 Bacilli rpsC GO:0000028,GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02982 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1TPCP@1239,4HAUR@91061,COG0092@1,COG0092@2 NA|NA|NA J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation HLLCKODE_01143 1046629.Ssal_00089 7.3e-53 213.0 Bacilli rplV GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02890 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V6PU@1239,4HIK2@91061,COG0091@1,COG0091@2 NA|NA|NA J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome HLLCKODE_01144 1000570.HMPREF9966_1567 8.3e-47 192.6 Streptococcus anginosus group rpsS GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02965 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V6CX@1239,42DQ5@671232,4HIG0@91061,COG0185@1,COG0185@2 NA|NA|NA J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA HLLCKODE_01145 1046629.Ssal_00087 6.8e-153 546.6 Bacilli rplB GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02886 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1TP9X@1239,4HAE8@91061,COG0090@1,COG0090@2 NA|NA|NA J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HLLCKODE_01146 264199.stu1932 2.4e-44 184.5 Bacilli rplW GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02892 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1VA4W@1239,4HKCV@91061,COG0089@1,COG0089@2 NA|NA|NA J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome HLLCKODE_01147 1046629.Ssal_00085 9.7e-104 382.9 Bacilli rplD GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003700,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0005886,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008428,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030234,GO:0030312,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032069,GO:0032074,GO:0032268,GO:0032269,GO:0032991,GO:0032993,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060698,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0065003,GO:0065007,GO:0065009,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:0098772,GO:0140110,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990904,GO:2000112,GO:2000113,GO:2001141 ko:K02926,ko:K16193 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1TPGW@1239,4HB01@91061,COG0088@1,COG0088@2 NA|NA|NA J Forms part of the polypeptide exit tunnel HLLCKODE_01148 1046629.Ssal_00084 2.4e-110 404.8 Bacilli rplC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010604,GO:0010628,GO:0015934,GO:0016020,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0031323,GO:0031325,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000232,GO:2000234 ko:K02906 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1TPFT@1239,4HAEN@91061,COG0087@1,COG0087@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit HLLCKODE_01149 1046629.Ssal_00083 2.9e-48 197.6 Bacilli rpsJ GO:0001072,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006355,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0015935,GO:0019219,GO:0019222,GO:0019538,GO:0022626,GO:0022627,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043244,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0140110,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2001141 ko:K02946 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V6C9@1239,4HIKH@91061,COG0051@1,COG0051@2 NA|NA|NA J Involved in the binding of tRNA to the ribosomes HLLCKODE_01150 1046629.Ssal_00081 1e-187 662.5 Bacilli ruvB GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 3.6.4.12 ko:K03551 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 1TR47@1239,4HBMW@91061,COG2255@1,COG2255@2 NA|NA|NA L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing HLLCKODE_01151 1046629.Ssal_00080 0.0 1156.0 Bacilli XK27_09800 Bacteria 1U6DU@1239,4H9XT@91061,COG1835@1,COG1835@2 NA|NA|NA I Acyltransferase HLLCKODE_01152 1046629.Ssal_00079 1.6e-33 149.1 Firmicutes XK27_09805 Bacteria 1TRNW@1239,COG4642@1,COG4642@2 NA|NA|NA S MORN repeat protein HLLCKODE_01153 1046629.Ssal_00078 9.8e-79 299.3 Bacilli ptpA 3.1.3.48 ko:K01104,ko:K20945 ko05111,map05111 ko00000,ko00001,ko01000 Bacteria 1V6SG@1239,4HIZN@91061,COG0394@1,COG0394@2 NA|NA|NA T Belongs to the low molecular weight phosphotyrosine protein phosphatase family HLLCKODE_01154 1046629.Ssal_00077 4.1e-250 870.2 Bacilli purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQ4C@1239,4H9YT@91061,COG0104@1,COG0104@2 NA|NA|NA F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP HLLCKODE_01155 1046629.Ssal_00076 3.2e-89 334.3 Bacilli adk 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1V7AW@1239,4HH8A@91061,COG0563@1,COG0563@2 NA|NA|NA F topology modulation protein HLLCKODE_01157 1000588.HMPREF9965_1531 4.7e-197 693.7 Streptococcus mitis ltrA Bacteria 1VAA8@1239,2TPNR@28037,4HMPC@91061,COG4292@1,COG4292@2 NA|NA|NA S Low temperature requirement protein HLLCKODE_01158 888048.HMPREF8577_1757 2.5e-173 614.8 Bacilli yeiH Bacteria 1TQYA@1239,4HCCP@91061,COG2855@1,COG2855@2 NA|NA|NA S membrane HLLCKODE_01159 1114965.Spaf_0325 8e-88 329.7 Bacteria Bacteria COG1476@1,COG1476@2 NA|NA|NA K sequence-specific DNA binding HLLCKODE_01160 1403946.Q615_SPAC00126G0051 1.5e-156 558.9 Streptococcus anginosus group ko:K07467 ko00000 Bacteria 1VMP1@1239,42EH0@671232,4HSQH@91061,COG2946@1,COG2946@2 NA|NA|NA L Replication initiation factor HLLCKODE_01161 585204.SMSK597_1426 1.4e-18 98.2 Streptococcus mitis Bacteria 1W5B5@1239,28YJG@1,2TQ3X@28037,2ZKDA@2,4I02K@91061 NA|NA|NA S Domain of unknown function (DUF3173) HLLCKODE_01162 388919.SSA_0235 1.6e-213 748.4 Bacilli int Bacteria 1VTS1@1239,4HU1E@91061,COG0582@1,COG0582@2 NA|NA|NA L Belongs to the 'phage' integrase family HLLCKODE_01164 1046629.Ssal_00070 8.2e-235 819.3 Bacilli rarA ko:K07478 ko00000 Bacteria 1TPVV@1239,4HAIS@91061,COG2256@1,COG2256@2 NA|NA|NA L ATPase related to the helicase subunit of the Holliday junction resolvase HLLCKODE_01165 1046629.Ssal_00069 8.4e-27 125.6 Bacilli rpmB GO:0003674,GO:0003735,GO:0005198 ko:K02902 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1VEI2@1239,4HNIK@91061,COG0227@1,COG0227@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL28 family HLLCKODE_01166 1046629.Ssal_00068 6.3e-44 183.0 Bacilli yrzL Bacteria 1VAC4@1239,4HKD0@91061,COG4472@1,COG4472@2 NA|NA|NA S Belongs to the UPF0297 family HLLCKODE_01167 435842.HMPREF0848_01740 1.8e-69 268.5 Bacilli yqgF GO:0000966,GO:0000967,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360 ko:K07447 ko00000,ko01000 Bacteria 1V6ER@1239,4HH04@91061,COG0816@1,COG0816@2 NA|NA|NA L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA HLLCKODE_01168 1046629.Ssal_00066 3.2e-44 184.1 Bacilli yrzB Bacteria 1VAPW@1239,4HKV7@91061,COG3906@1,COG3906@2 NA|NA|NA S Belongs to the UPF0473 family HLLCKODE_01169 1046629.Ssal_00065 1.3e-285 988.4 Bacilli ccs Bacteria 1V9D8@1239,2F2IJ@1,33VFI@2,4HS77@91061 NA|NA|NA S the current gene model (or a revised gene model) may contain a frame shift HLLCKODE_01170 1046629.Ssal_00064 0.0 1486.5 Bacilli nrdD GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008998,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0015949,GO:0016491,GO:0016725,GO:0016728,GO:0017076,GO:0018130,GO:0019001,GO:0019103,GO:0019438,GO:0019637,GO:0019692,GO:0030554,GO:0031250,GO:0032552,GO:0032553,GO:0032554,GO:0032555,GO:0032556,GO:0032558,GO:0032559,GO:0032560,GO:0032564,GO:0032567,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046385,GO:0046483,GO:0046872,GO:0046914,GO:0051065,GO:0055086,GO:0055114,GO:0071704,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576 1.1.98.6 ko:K21636 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R11633,R11634,R11635,R11636 RC00613 ko00000,ko00001,ko00002,ko01000 iECIAI39_1322.ECIAI39_4713,iPC815.YPO3454 Bacteria 1TR9K@1239,4HBIY@91061,COG1327@1,COG1327@2,COG1328@1,COG1328@2 NA|NA|NA F Ribonucleoside-triphosphate reductase HLLCKODE_01171 435842.HMPREF0848_01736 7.5e-14 82.0 Bacilli Bacteria 1TXD1@1239,2DEKJ@1,2ZNBP@2,4HZYT@91061 NA|NA|NA HLLCKODE_01172 904306.HMPREF9192_1930 3.3e-86 324.3 Bacilli XK27_10930 Bacteria 1V1C4@1239,4HG6C@91061,COG3981@1,COG3981@2 NA|NA|NA K acetyltransferase HLLCKODE_01173 1046629.Ssal_00061 1.9e-112 411.8 Bacilli nrdG GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008998,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0015949,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0019692,GO:0031250,GO:0032991,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046385,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901576 1.97.1.4 ko:K04068 R04710 ko00000,ko01000 iE2348C_1286.E2348C_4563 Bacteria 1V1HG@1239,4HGJ9@91061,COG0602@1,COG0602@2 NA|NA|NA O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine HLLCKODE_01174 1046629.Ssal_00060 3.3e-119 434.5 Bacilli yaaA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0033194,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:1901700 ko:K09861 ko00000 Bacteria 1TR33@1239,4HFN2@91061,COG3022@1,COG3022@2 NA|NA|NA S Belongs to the UPF0246 family HLLCKODE_01175 904306.HMPREF9192_1927 9.3e-167 592.8 Bacilli XK27_01785 Bacteria 1TRBT@1239,4HBPR@91061,COG1284@1,COG1284@2 NA|NA|NA S cog cog1284 HLLCKODE_01176 1046629.Ssal_00058 0.0 1139.4 Bacilli aspS 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Bacteria 1TPCN@1239,4HACD@91061,COG0173@1,COG0173@2 NA|NA|NA J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) HLLCKODE_01178 1046629.Ssal_00055 1.8e-237 828.2 Bacilli hisS 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1TP3D@1239,4HAM2@91061,COG0124@1,COG0124@2 NA|NA|NA J histidyl-tRNA synthetase HLLCKODE_01179 1046629.Ssal_00054 5.5e-80 303.9 Bacilli 2.7.1.201,2.7.1.208,2.7.1.211 ko:K02755,ko:K02756,ko:K02757,ko:K02777,ko:K02808,ko:K02809,ko:K02810,ko:K02817,ko:K02818,ko:K02819,ko:K20107,ko:K20108 ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111 M00265,M00266,M00268,M00269,M00270,M00271,M00272,M00303,M00806 R00811,R02738,R02780,R04111,R04394,R05132,R08559 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.1,4.A.1.1.11,4.A.1.1.12,4.A.1.2.1,4.A.1.2.10,4.A.1.2.11,4.A.1.2.12,4.A.1.2.13,4.A.1.2.2,4.A.1.2.4,4.A.1.2.5,4.A.1.2.6,4.A.1.2.8,4.A.1.2.9 Bacteria 1TP5X@1239,4HA0I@91061,COG1263@1,COG1263@2,COG1264@1,COG1264@2 NA|NA|NA G pts system HLLCKODE_01180 1046629.Ssal_00054 8.9e-51 206.1 Bacilli 2.7.1.201,2.7.1.208,2.7.1.211 ko:K02755,ko:K02756,ko:K02757,ko:K02777,ko:K02808,ko:K02809,ko:K02810,ko:K02817,ko:K02818,ko:K02819,ko:K20107,ko:K20108 ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111 M00265,M00266,M00268,M00269,M00270,M00271,M00272,M00303,M00806 R00811,R02738,R02780,R04111,R04394,R05132,R08559 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.1,4.A.1.1.11,4.A.1.1.12,4.A.1.2.1,4.A.1.2.10,4.A.1.2.11,4.A.1.2.12,4.A.1.2.13,4.A.1.2.2,4.A.1.2.4,4.A.1.2.5,4.A.1.2.6,4.A.1.2.8,4.A.1.2.9 Bacteria 1TP5X@1239,4HA0I@91061,COG1263@1,COG1263@2,COG1264@1,COG1264@2 NA|NA|NA G pts system HLLCKODE_01181 1046629.Ssal_00054 1.4e-07 61.2 Bacilli 2.7.1.201,2.7.1.208,2.7.1.211 ko:K02755,ko:K02756,ko:K02757,ko:K02777,ko:K02808,ko:K02809,ko:K02810,ko:K02817,ko:K02818,ko:K02819,ko:K20107,ko:K20108 ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111 M00265,M00266,M00268,M00269,M00270,M00271,M00272,M00303,M00806 R00811,R02738,R02780,R04111,R04394,R05132,R08559 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.1,4.A.1.1.11,4.A.1.1.12,4.A.1.2.1,4.A.1.2.10,4.A.1.2.11,4.A.1.2.12,4.A.1.2.13,4.A.1.2.2,4.A.1.2.4,4.A.1.2.5,4.A.1.2.6,4.A.1.2.8,4.A.1.2.9 Bacteria 1TP5X@1239,4HA0I@91061,COG1263@1,COG1263@2,COG1264@1,COG1264@2 NA|NA|NA G pts system HLLCKODE_01182 1046629.Ssal_00053 1.2e-218 765.4 Bacilli metE 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPDQ@1239,4HADW@91061,COG0620@1,COG0620@2 NA|NA|NA E Methionine synthase HLLCKODE_01183 1046629.Ssal_00052 3.4e-25 120.2 Bacilli rpmF GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904 ko:K02911 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011,ko03029 Bacteria 1VKMZ@1239,4HR2Q@91061,COG0333@1,COG0333@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL32 family HLLCKODE_01184 1046629.Ssal_00051 6.7e-19 99.0 Bacteria rpmG GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046677,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02913 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria COG0267@1,COG0267@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL33 family HLLCKODE_01185 655813.HMPREF8579_1606 3.3e-28 131.3 Streptococcus oralis Bacteria 1TX2H@1239,1WQ5V@1303,2DJ4Z@1,304RK@2,4I5YE@91061 NA|NA|NA HLLCKODE_01188 1000570.HMPREF9966_1479 7.4e-80 305.8 Bacilli Bacteria 1VBUT@1239,2DCWR@1,2ZFMN@2,4I1YA@91061 NA|NA|NA HLLCKODE_01189 1123315.AUIP01000018_gene2129 2.9e-46 191.0 Bacilli Bacteria 1V88H@1239,4HMXE@91061,COG1396@1,COG1396@2 NA|NA|NA K DNA-binding protein HLLCKODE_01193 1123315.AUIP01000018_gene2125 2.7e-121 441.4 Bacteria Bacteria COG1674@1,COG1674@2 NA|NA|NA D ftsk spoiiie HLLCKODE_01194 862970.SAIN_1780 2.1e-206 724.9 Bacilli Bacteria 1V478@1239,294J7@1,2ZRYS@2,4HWDS@91061 NA|NA|NA S Replication initiation factor HLLCKODE_01195 1403946.Q615_SPAC00137G0104 2.8e-28 131.0 Streptococcus anginosus group Bacteria 1W1XC@1239,2DFC8@1,2ZRAH@2,42DRU@671232,4I1SX@91061 NA|NA|NA S MerR HTH family regulatory protein HLLCKODE_01196 862971.SANR_2065 6.8e-221 773.1 Streptococcus anginosus group sip Bacteria 1VRHF@1239,42D7Z@671232,4HUTG@91061,COG0582@1,COG0582@2 NA|NA|NA L Belongs to the 'phage' integrase family HLLCKODE_01197 435842.HMPREF0848_01725 9.8e-55 219.2 Bacilli Bacteria 1VX57@1239,4HXQ2@91061,COG1733@1,COG1733@2 NA|NA|NA K HxlR-like helix-turn-helix HLLCKODE_01198 563038.HMPREF0851_00116 2.2e-15 87.0 Bacteria Bacteria 2DNIA@1,32XNW@2 NA|NA|NA S Pseudomonas avirulence D protein (AvrD) HLLCKODE_01199 365659.smi_1784 2.5e-237 827.8 Bacilli mmr GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K08166 ko00000,ko02000 2.A.1.3.10 Bacteria 1V2WI@1239,4HGNH@91061,COG0477@1,COG0477@2 NA|NA|NA P Major Facilitator Superfamily HLLCKODE_01200 904306.HMPREF9192_1907 1e-110 406.0 Bacilli nudL GO:0003674,GO:0003824,GO:0016787,GO:0016817,GO:0016818 Bacteria 1V6SF@1239,4HG46@91061,COG0494@1,COG0494@2 NA|NA|NA L hydrolase HLLCKODE_01201 904306.HMPREF9192_1906 3.2e-50 204.1 Bacilli ko:K10947 ko00000,ko03000 Bacteria 1VIVQ@1239,4IR4R@91061,COG1695@1,COG1695@2 NA|NA|NA K transcriptional regulator, PadR family HLLCKODE_01202 904306.HMPREF9192_1905 8.3e-57 226.9 Bacilli XK27_06920 Bacteria 1VBG6@1239,4HSRQ@91061,COG4709@1,COG4709@2 NA|NA|NA S Protein of unknown function (DUF1700) HLLCKODE_01203 1046629.Ssal_00035 3.2e-102 378.3 Firmicutes Bacteria 1VGGF@1239,COG3595@1,COG3595@2 NA|NA|NA S Putative adhesin HLLCKODE_01204 904306.HMPREF9192_1903 1.5e-157 563.5 Bacilli XK27_06930 ko:K01421 ko00000 Bacteria 1TQ15@1239,4H9T9@91061,COG1511@1,COG1511@2 NA|NA|NA V domain protein HLLCKODE_01205 1046629.Ssal_00033 4.6e-94 350.5 Bacteria XK27_06935 Bacteria COG1309@1,COG1309@2 NA|NA|NA K transcriptional regulator HLLCKODE_01206 1046629.Ssal_00032 2.7e-53 214.5 Firmicutes ypaA ko:K08987 ko00000 Bacteria 1VAEU@1239,COG3759@1,COG3759@2 NA|NA|NA M Membrane HLLCKODE_01207 1123318.KB904633_gene1270 1.1e-10 72.0 Bacilli Bacteria 1W3FT@1239,2914P@1,2ZNS1@2,4I23Q@91061 NA|NA|NA HLLCKODE_01208 1046629.Ssal_00030 5.8e-109 400.2 Bacilli rpsD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 ko:K02986 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1TR0J@1239,4HAC9@91061,COG0522@1,COG0522@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit HLLCKODE_01209 1046629.Ssal_00029 1.8e-47 194.9 Bacilli veg Bacteria 1VPZY@1239,4HSFF@91061,COG4466@1,COG4466@2 NA|NA|NA S Biofilm formation stimulator VEG HLLCKODE_01210 1046629.Ssal_00028 3.2e-245 854.0 Bacilli dnaB GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 ko00000,ko00001,ko01000,ko03032 Bacteria 1TPCT@1239,4H9Y8@91061,COG0305@1,COG0305@2 NA|NA|NA L Participates in initiation and elongation during chromosome replication HLLCKODE_01211 1046629.Ssal_00027 2.2e-73 281.6 Bacilli rplI GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02939 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V6QG@1239,4HIKJ@91061,COG0359@1,COG0359@2 NA|NA|NA J binds to the 23S rRNA HLLCKODE_01212 904306.HMPREF9192_1894 0.0 1222.2 Bacilli yybT Bacteria 1TPGP@1239,4HBVH@91061,COG3887@1,COG3887@2 NA|NA|NA T signaling protein consisting of a modified GGDEF domain and a DHH domain HLLCKODE_01213 1046629.Ssal_00025 0.0 1230.7 Bacilli gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 ko:K03495 R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 Bacteria 1TQ4B@1239,4HA6S@91061,COG0445@1,COG0445@2 NA|NA|NA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 HLLCKODE_01214 467705.SGO_0023 7.8e-98 363.2 Bacilli yvbG ko:K05595 ko00000,ko02000 2.A.95.1 Bacteria 1V81W@1239,4HIUV@91061,COG2095@1,COG2095@2 NA|NA|NA U UPF0056 membrane protein HLLCKODE_01215 1046629.Ssal_00023 2.1e-218 764.6 Bacilli mnmA GO:0001510,GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0003824,GO:0004808,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016782,GO:0016783,GO:0030488,GO:0032259,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.8.1.13 ko:K00566 ko04122,map04122 R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 Bacteria 1TPIZ@1239,4HBJ6@91061,COG0482@1,COG0482@2 NA|NA|NA J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 HLLCKODE_01216 1046629.Ssal_00022 1.8e-145 521.9 Bacilli Bacteria 1V0XZ@1239,4HEBN@91061,COG4485@1,COG4485@2 NA|NA|NA S Bacterial membrane protein, YfhO HLLCKODE_01217 1046629.Ssal_00022 5.6e-150 537.0 Bacilli Bacteria 1V0XZ@1239,4HEBN@91061,COG4485@1,COG4485@2 NA|NA|NA S Bacterial membrane protein, YfhO HLLCKODE_01218 1046629.Ssal_00021 4.5e-65 254.6 Bacilli isaA ko:K21687 ko00000 GH23 Bacteria 1VGPA@1239,4HP1I@91061,COG0741@1,COG0741@2 NA|NA|NA M Immunodominant staphylococcal antigen A HLLCKODE_01219 1046629.Ssal_00020 2.5e-61 241.9 Bacilli lytE Bacteria 1VA10@1239,4HMUH@91061,COG1388@1,COG1388@2 NA|NA|NA M LysM domain protein HLLCKODE_01220 264199.stu2007 2.2e-132 478.4 Bacilli ecfT GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015238,GO:0015711,GO:0015893,GO:0016020,GO:0022857,GO:0032217,GO:0032218,GO:0034220,GO:0035461,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051180,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0090482,GO:0098656 ko:K02008,ko:K16783,ko:K16785 ko02010,map02010 M00245,M00246,M00581,M00582 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23,3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 Bacteria 1TQ0E@1239,4H9VT@91061,COG0619@1,COG0619@2 NA|NA|NA P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates HLLCKODE_01221 1046629.Ssal_00018 1.4e-150 538.9 Bacilli ecfA2 GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0008144,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015238,GO:0015711,GO:0015893,GO:0016020,GO:0017076,GO:0022857,GO:0030554,GO:0032217,GO:0032218,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035461,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0044464,GO:0050896,GO:0051179,GO:0051180,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0090482,GO:0097159,GO:0097367,GO:0098656,GO:1901265,GO:1901363 3.6.3.55 ko:K02068,ko:K06857,ko:K16784,ko:K16786,ko:K16787 ko02010,map02010 M00186,M00211,M00581,M00582 R10531 RC00002 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35,3.A.1.6.2,3.A.1.6.4 Bacteria 1TPH8@1239,4HA7T@91061,COG1122@1,COG1122@2 NA|NA|NA P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates HLLCKODE_01222 1046629.Ssal_00017 2.7e-149 534.6 Bacilli ecfA1 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015238,GO:0015711,GO:0015893,GO:0016020,GO:0022857,GO:0032217,GO:0032218,GO:0034220,GO:0035461,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051180,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0090482,GO:0098656 ko:K16784,ko:K16786,ko:K16787 ko02010,map02010 M00581,M00582 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 Bacteria 1TPH8@1239,4H9R8@91061,COG1122@1,COG1122@2 NA|NA|NA P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates HLLCKODE_01223 1046629.Ssal_00016 2.6e-89 334.7 Bacilli pgsA GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 iSB619.SA_RS06365 Bacteria 1V6PJ@1239,4HCEX@91061,COG0558@1,COG0558@2 NA|NA|NA I Belongs to the CDP-alcohol phosphatidyltransferase class-I family HLLCKODE_01224 1046629.Ssal_00015 1.7e-127 462.2 Bacteria ko:K15539 ko00000 Bacteria COG1426@1,COG1426@2 NA|NA|NA S sequence-specific DNA binding HLLCKODE_01225 1046629.Ssal_00014 4.1e-234 817.0 Bacilli ymfH ko:K07263 ko00000,ko01000,ko01002 Bacteria 1TP5I@1239,4H9YG@91061,COG0612@1,COG0612@2 NA|NA|NA S Peptidase M16 HLLCKODE_01226 1046629.Ssal_00013 1.8e-226 791.6 Bacilli ymfF Bacteria 1TPN6@1239,4H9P5@91061,COG0612@1,COG0612@2 NA|NA|NA S Peptidase M16 HLLCKODE_01227 1046629.Ssal_00012 6.4e-58 229.9 Bacilli yaaA GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K14761 ko00000,ko03009 Bacteria 1VKF4@1239,4HRX5@91061,COG2501@1,COG2501@2 NA|NA|NA S S4 domain protein YaaA HLLCKODE_01228 1046629.Ssal_00011 1.2e-200 705.7 Bacilli recF GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 ko:K03629 ko03440,map03440 ko00000,ko00001,ko03400 Bacteria 1TP9U@1239,4HA0W@91061,COG1195@1,COG1195@2 NA|NA|NA L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP HLLCKODE_01229 1046629.Ssal_00010 2.3e-273 947.6 Bacilli guaB GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 iAPECO1_1312.APECO1_4018,iECABU_c1320.ECABU_c28100,iECP_1309.ECP_2510,iECSF_1327.ECSF_2349,iUTI89_1310.UTI89_C2826,ic_1306.c3027 Bacteria 1TNZ1@1239,4H9V3@91061,COG0516@1,COG0516@2,COG0517@1,COG0517@2 NA|NA|NA F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth HLLCKODE_01230 1046629.Ssal_00009 7.2e-189 666.4 Bacilli trpS GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1TPY7@1239,4HA1K@91061,COG0180@1,COG0180@2 NA|NA|NA J Tryptophanyl-tRNA synthetase HLLCKODE_01231 1046629.Ssal_00008 9.3e-153 546.2 Bacilli yvjA Bacteria 1TR9J@1239,4H9N6@91061,COG1284@1,COG1284@2 NA|NA|NA S membrane HLLCKODE_01232 904306.HMPREF9192_1872 1.9e-305 1054.3 Bacilli ybiT GO:0006950,GO:0008150,GO:0009266,GO:0009409,GO:0009628,GO:0050896 ko:K06158 ko00000,ko03012 Bacteria 1TPW0@1239,4HATH@91061,COG0488@1,COG0488@2 NA|NA|NA S abc transporter atp-binding protein HLLCKODE_01233 1046629.Ssal_00006 0.0 1615.5 Bacilli XK27_10405 Bacteria 1TRR1@1239,4HCR9@91061,COG4485@1,COG4485@2 NA|NA|NA S Bacterial membrane protein YfhO HLLCKODE_01237 1046629.Ssal_00005 2.2e-117 428.3 Bacteria yoaK Bacteria COG3619@1,COG3619@2 NA|NA|NA S Protein of unknown function (DUF1275) HLLCKODE_01238 1046629.Ssal_00004 6.8e-81 306.6 Bacilli rlmH 2.1.1.177 ko:K00783 ko00000,ko01000,ko03009 Bacteria 1V3JM@1239,4HFP8@91061,COG1576@1,COG1576@2 NA|NA|NA J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA HLLCKODE_01239 1046629.Ssal_00003 1.5e-201 708.8 Bacilli htrA GO:0008150,GO:0009266,GO:0009628,GO:0050896 3.4.21.107 ko:K04691,ko:K04771 ko01503,ko02020,map01503,map02020 M00728 ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 Bacteria 1TRM8@1239,4HA31@91061,COG0265@1,COG0265@2 NA|NA|NA O Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain' HLLCKODE_01240 1046629.Ssal_00002 4.2e-133 480.7 Bacilli parB ko:K03497 ko00000,ko03000,ko03036,ko04812 Bacteria 1TQ2B@1239,4H9TB@91061,COG1475@1,COG1475@2 NA|NA|NA K Belongs to the ParB family HLLCKODE_01241 1046629.Ssal_00001 3.2e-253 880.6 Bacilli dnaA GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 ko:K02313 ko02020,ko04112,map02020,map04112 ko00000,ko00001,ko03032,ko03036 Bacteria 1TPV7@1239,4H9MW@91061,COG0593@1,COG0593@2 NA|NA|NA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids HLLCKODE_01242 904306.HMPREF9192_1861 4.2e-198 697.2 Bacilli dnaN 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 1TQ7J@1239,4H9TF@91061,COG0592@1,COG0592@2 NA|NA|NA L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria HLLCKODE_01243 1046629.Ssal_02164 3.2e-29 133.7 Bacilli yyzM Bacteria 1VEQ7@1239,4HNHU@91061,COG4481@1,COG4481@2 NA|NA|NA S Protein conserved in bacteria HLLCKODE_01244 1046629.Ssal_02163 1.1e-203 715.7 Bacilli ychF GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0043021,GO:0043022,GO:0043023,GO:0043086,GO:0044092,GO:0044424,GO:0044464,GO:0044877,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0098772 ko:K06942 ko00000,ko03009 Bacteria 1TPRK@1239,4H9SQ@91061,COG0012@1,COG0012@2 NA|NA|NA J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner HLLCKODE_01245 1046629.Ssal_02162 3e-104 384.4 Bacilli pth GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016788,GO:0040007,GO:0044464,GO:0052689,GO:0071944,GO:0140098,GO:0140101 3.1.1.29 ko:K01056 ko00000,ko01000,ko03012 Bacteria 1V3NB@1239,4HH2Z@91061,COG0193@1,COG0193@2 NA|NA|NA J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis HLLCKODE_01246 1046629.Ssal_02161 0.0 2234.9 Bacilli mfd ko:K03723 ko03420,map03420 ko00000,ko00001,ko01000,ko03400 Bacteria 1TPF1@1239,4H9NB@91061,COG1197@1,COG1197@2 NA|NA|NA L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site HLLCKODE_01247 1046629.Ssal_02160 6.3e-39 166.4 Bacilli yabO GO:0008150,GO:0040007 Bacteria 1VEI5@1239,4HKJJ@91061,COG1188@1,COG1188@2 NA|NA|NA J Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) HLLCKODE_01248 322159.STER_0009 3e-60 237.7 Bacilli divIC ko:K05589,ko:K13052 ko00000,ko03036 Bacteria 1VKC5@1239,4HR53@91061,COG2919@1,COG2919@2 NA|NA|NA D Septum formation initiator HLLCKODE_01250 1046629.Ssal_02157 7.9e-233 812.8 Bacilli XK27_09285 3.5.2.6 ko:K01467,ko:K17836 ko00311,ko01130,ko01501,ko02020,map00311,map01130,map01501,map02020 M00627,M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000,ko01504 Bacteria 1VGXR@1239,4IPWW@91061,COG2367@1,COG2367@2 NA|NA|NA V Beta-lactamase enzyme family HLLCKODE_01251 1046629.Ssal_02156 4.7e-230 803.5 Bacilli tilS 2.4.2.8,6.3.4.19 ko:K04075,ko:K15780 ko00230,ko01100,ko01110,map00230,map01100,map01110 R01132,R01229,R02142,R09597 RC00063,RC00122,RC02633,RC02634 ko00000,ko00001,ko01000,ko03016 Bacteria 1TPXP@1239,4H9ZM@91061,COG0037@1,COG0037@2 NA|NA|NA D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine HLLCKODE_01252 1046629.Ssal_02155 4.2e-95 354.0 Bacilli hpt GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.2.8,6.3.4.19 ko:K00760,ko:K15780 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000,ko03016 Bacteria 1V1C9@1239,4HFZ2@91061,COG0634@1,COG0634@2 NA|NA|NA F Belongs to the purine pyrimidine phosphoribosyltransferase family HLLCKODE_01253 1046629.Ssal_02154 0.0 1247.3 Bacilli ftsH GO:0003674,GO:0003824,GO:0004176,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0030428,GO:0032502,GO:0042623,GO:0043170,GO:0043934,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 ko:K03798 M00742 ko00000,ko00002,ko01000,ko01002,ko03110 Bacteria 1TPTV@1239,4HAJB@91061,COG0465@1,COG0465@2 NA|NA|NA O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins HLLCKODE_01254 1046629.Ssal_01239 1.2e-208 732.3 Bacilli metK GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPCV@1239,4HB33@91061,COG0192@1,COG0192@2 NA|NA|NA H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme HLLCKODE_01255 1046629.Ssal_01240 2.2e-168 598.2 Bacilli birA GO:0000166,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004077,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009305,GO:0009374,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0017053,GO:0017076,GO:0017144,GO:0018130,GO:0018271,GO:0019538,GO:0019752,GO:0019842,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032991,GO:0033218,GO:0033293,GO:0034641,GO:0035639,GO:0036094,GO:0036211,GO:0042364,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043565,GO:0043603,GO:0043604,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1990837 6.3.4.15 ko:K03524,ko:K04096 ko00780,ko01100,map00780,map01100 R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 Bacteria 1TQCU@1239,4HB60@91061,COG0340@1,COG0340@2,COG1654@1,COG1654@2 NA|NA|NA HK Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor HLLCKODE_01256 1046629.Ssal_01242 1.1e-300 1038.5 Bacilli dnaX GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576 2.7.7.7 ko:K02341,ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 1TPS9@1239,4HAUE@91061,COG2812@1,COG2812@2 NA|NA|NA L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity HLLCKODE_01257 1046629.Ssal_01243 1.4e-84 318.9 Bacilli ytsP 1.8.4.14 ko:K08968 ko00270,map00270 R02025 RC00639 ko00000,ko00001,ko01000 Bacteria 1V6GQ@1239,4HH7X@91061,COG1956@1,COG1956@2 NA|NA|NA T GAF domain-containing protein HLLCKODE_01258 1046629.Ssal_01244 6.9e-159 566.6 Bacilli miaA GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 Bacteria 1TPSC@1239,4HAVW@91061,COG0324@1,COG0324@2 NA|NA|NA J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) HLLCKODE_01259 1046629.Ssal_01245 3.2e-20 103.6 Bacilli WQ51_02665 Bacteria 1VPEZ@1239,2C91M@1,33E1E@2,4HRR2@91061 NA|NA|NA S Protein of unknown function (DUF3042) HLLCKODE_01262 1046629.Ssal_01252 1.1e-56 225.7 Bacilli rplS GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02884 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V6FT@1239,4HIK3@91061,COG0335@1,COG0335@2 NA|NA|NA J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site HLLCKODE_01263 1046629.Ssal_01253 9.5e-212 742.7 Firmicutes XK27_05110 Bacteria 1TPX0@1239,COG0038@1,COG0038@2 NA|NA|NA P Chloride transporter ClC family HLLCKODE_01264 904306.HMPREF9192_1605 1.8e-38 164.9 Bacteria pheA GO:0003674,GO:0003824,GO:0004106,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 1.3.1.12,2.3.1.79,4.2.1.51,5.4.99.5 ko:K00661,ko:K04092,ko:K04093,ko:K04516,ko:K14170,ko:K14187 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715,R01728 RC00125,RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 iECNA114_1301.ECNA114_2667 Bacteria COG1605@1,COG1605@2 NA|NA|NA E Chorismate mutase HLLCKODE_01265 1046629.Ssal_01255 2.1e-280 971.1 Bacilli clcA GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006821,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015672,GO:0015698,GO:0015706,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0031404,GO:0034220,GO:0042802,GO:0043167,GO:0043168,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071705,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 ko:K03281 ko00000 2.A.49 iAF1260.b0155,iB21_1397.B21_00153,iBWG_1329.BWG_0148,iE2348C_1286.E2348C_0162,iEC042_1314.EC042_0155,iEC55989_1330.EC55989_0149,iECBD_1354.ECBD_3463,iECDH10B_1368.ECDH10B_0135,iECDH1ME8569_1439.ECDH1ME8569_0149,iECD_1391.ECD_00154,iECIAI1_1343.ECIAI1_0153,iECO103_1326.ECO103_0155,iECSE_1348.ECSE_0156,iECUMN_1333.ECUMN_0152,iECW_1372.ECW_m0152,iEKO11_1354.EKO11_3761,iETEC_1333.ETEC_0151,iEcDH1_1363.EcDH1_3447,iEcE24377_1341.EcE24377A_0160,iEcolC_1368.EcolC_3504,iJO1366.b0155,iSSON_1240.SSON_0167,iUMNK88_1353.UMNK88_159,iWFL_1372.ECW_m0152,iY75_1357.Y75_RS00790,iZ_1308.Z0166 Bacteria 1TPX0@1239,4HD2H@91061,COG0038@1,COG0038@2 NA|NA|NA P Chloride transporter, ClC family HLLCKODE_01266 1046629.Ssal_01256 1e-75 289.3 Bacilli fld ko:K03839 ko00000 Bacteria 1V7AG@1239,4HMJF@91061,COG0716@1,COG0716@2 NA|NA|NA C Flavodoxin HLLCKODE_01267 996306.SSUR61_0275 2.8e-18 98.2 Streptococcus suis XK27_08880 Bacteria 1U92D@1239,1WTJN@1307,29R1H@1,30C2M@2,4IJ2X@91061 NA|NA|NA HLLCKODE_01268 1046629.Ssal_01259 5.5e-127 460.3 Bacilli XK27_08875 Bacteria 1VW9X@1239,4HWF8@91061,COG5549@1,COG5549@2 NA|NA|NA O Zinc-dependent metalloprotease HLLCKODE_01269 1046629.Ssal_01260 9.5e-149 532.7 Bacilli estA ko:K03930 ko00000,ko01000 CE1 Bacteria 1TPA9@1239,4HD64@91061,COG0627@1,COG0627@2 NA|NA|NA S Esterase HLLCKODE_01270 1046629.Ssal_01262 7.8e-310 1068.9 Bacilli rnjB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360 ko:K12574 ko03018,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 1TQ9G@1239,4HAAP@91061,COG0595@1,COG0595@2 NA|NA|NA S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay HLLCKODE_01271 1046629.Ssal_01263 3.1e-136 491.1 Bacilli XK27_08845 ko:K05833 M00247 ko00000,ko00002,ko02000 Bacteria 1TPAN@1239,4HCHC@91061,COG1101@1,COG1101@2 NA|NA|NA S abc transporter atp-binding protein HLLCKODE_01272 1046629.Ssal_01264 2.6e-147 528.1 Bacilli XK27_08840 ko:K01989,ko:K05832 M00247 ko00000,ko00002,ko02000 Bacteria 1TPDJ@1239,4HBMY@91061,COG4120@1,COG4120@2 NA|NA|NA S Belongs to the binding-protein-dependent transport system permease family HLLCKODE_01273 1046629.Ssal_01265 2.4e-176 624.8 Bacilli XK27_08835 ko:K01989,ko:K05832 M00247 ko00000,ko00002,ko02000 Bacteria 1TPB0@1239,4HE7G@91061,COG2984@1,COG2984@2 NA|NA|NA S ABC transporter substrate binding protein HLLCKODE_01274 1095738.HMPREF1047_0924 1.7e-18 98.2 Streptococcus oralis Bacteria 1TWZ1@1239,1WPY9@1303,2DJ35@1,304P3@2,4I5TZ@91061 NA|NA|NA S Domain of unknown function (DUF4649) HLLCKODE_01275 1316408.HSISM1_1365 2.8e-241 841.6 Bacilli ko:K14194 ko05150,map05150 ko00000,ko00001 Bacteria 1TV1Y@1239,4HBHJ@91061,COG2373@1,COG2373@2 NA|NA|NA Q the current gene model (or a revised gene model) may contain a frame shift HLLCKODE_01276 322159.STER_1539 9.7e-155 552.7 Bacilli cjaA ko:K02030 M00236 ko00000,ko00002,ko02000 3.A.1.3 Bacteria 1TT11@1239,4HFBQ@91061,COG0834@1,COG0834@2 NA|NA|NA ET ABC transporter substrate-binding protein HLLCKODE_01277 1046629.Ssal_00475 2.2e-134 485.0 Bacilli glnQ 3.6.3.21 ko:K02028 M00236 ko00000,ko00002,ko01000,ko02000 3.A.1.3 Bacteria 1TNYD@1239,4HDK7@91061,COG1126@1,COG1126@2 NA|NA|NA E abc transporter atp-binding protein HLLCKODE_01278 1046629.Ssal_00474 3e-106 391.3 Bacilli ko:K02029 M00236 ko00000,ko00002,ko02000 3.A.1.3 Bacteria 1TR7R@1239,4HGVA@91061,COG0765@1,COG0765@2 NA|NA|NA P ABC transporter (Permease HLLCKODE_01279 904306.HMPREF9192_2072 1.3e-114 419.1 Bacilli papP ko:K02029 M00236 ko00000,ko00002,ko02000 3.A.1.3 Bacteria 1TRU3@1239,4HGE1@91061,COG0765@1,COG0765@2 NA|NA|NA P ABC transporter (Permease HLLCKODE_01280 904306.HMPREF9192_0803 2.1e-191 674.9 Bacilli ddl 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 Bacteria 1TP2Y@1239,4H9KB@91061,COG1181@1,COG1181@2 NA|NA|NA F Belongs to the D-alanine--D-alanine ligase family HLLCKODE_01281 435842.HMPREF0848_01205 1.4e-30 138.3 Bacilli copZ GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006810,GO:0006811,GO:0006812,GO:0006873,GO:0006875,GO:0008150,GO:0009987,GO:0019725,GO:0030001,GO:0030003,GO:0042592,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0055065,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0098771 2.7.7.77 ko:K03752,ko:K07213,ko:K08364 ko00790,ko01100,ko04978,map00790,map01100,map04978 R11581 ko00000,ko00001,ko01000,ko02000 1.A.72.1 Bacteria 1VK5F@1239,4HR1Z@91061,COG2608@1,COG2608@2 NA|NA|NA P Heavy metal-associated domain protein HLLCKODE_01282 1046629.Ssal_00470 0.0 1303.1 Bacilli copA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 Bacteria 1TP5S@1239,4HAI0@91061,COG2217@1,COG2217@2 NA|NA|NA P P-type ATPase HLLCKODE_01283 435842.HMPREF0848_01207 1.2e-73 282.3 Bacteria copY Bacteria COG3682@1,COG3682@2 NA|NA|NA K negative regulation of transcription, DNA-templated HLLCKODE_01286 1046629.Ssal_00465 3.5e-143 514.2 Bacilli trpA 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPXA@1239,4HFQ8@91061,COG0159@1,COG0159@2 NA|NA|NA E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate HLLCKODE_01287 1046629.Ssal_00464 3.4e-230 803.9 Bacilli trpB GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20,5.3.1.24 ko:K01696,ko:K01817 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722,R03509 RC00209,RC00210,RC00700,RC00701,RC00945,RC02868 ko00000,ko00001,ko00002,ko01000 iYO844.BSU22640 Bacteria 1TPI3@1239,4H9WC@91061,COG0133@1,COG0133@2 NA|NA|NA E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine HLLCKODE_01288 435842.HMPREF0848_01210 2.5e-98 364.8 Bacilli trpF GO:0000162,GO:0003674,GO:0003824,GO:0004425,GO:0004640,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.48,4.2.1.160,4.2.1.20,5.3.1.24 ko:K01696,ko:K01817,ko:K13498,ko:K22100 ko00260,ko00400,ko00790,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map00790,map01100,map01110,map01130,map01230 M00023,M00840 R00674,R02340,R02722,R03508,R03509,R11072 RC00209,RC00210,RC00700,RC00701,RC00944,RC00945,RC02868,RC03343 ko00000,ko00001,ko00002,ko01000 iJN678.trpF,iPC815.YPO2205,iSBO_1134.SBO_1804,iSDY_1059.SDY_1330 Bacteria 1V6Y0@1239,4HK18@91061,COG0135@1,COG0135@2 NA|NA|NA E belongs to the TrpF family HLLCKODE_01289 1046629.Ssal_00461 1.2e-132 479.2 Bacilli trpC GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48,5.3.1.24 ko:K01609,ko:K01817,ko:K13498 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508,R03509 RC00944,RC00945 ko00000,ko00001,ko00002,ko01000 Bacteria 1TR94@1239,4HG9K@91061,COG0134@1,COG0134@2 NA|NA|NA E Belongs to the TrpC family HLLCKODE_01290 904306.HMPREF9192_0788 1.5e-178 632.1 Bacilli trpD GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 ko:K00766,ko:K13497 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01073 RC00010,RC00440,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP8U@1239,4H9KQ@91061,COG0547@1,COG0547@2 NA|NA|NA F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) HLLCKODE_01291 1046629.Ssal_00458 2.6e-103 381.3 Bacilli trpG 2.4.2.18,2.6.1.85,4.1.3.27 ko:K00766,ko:K01658,ko:K01664,ko:K13497 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01073,R01716 RC00010,RC00440,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 Bacteria 1V4RM@1239,4HHD8@91061,COG0512@1,COG0512@2 NA|NA|NA EH anthranilate HLLCKODE_01292 904306.HMPREF9192_0786 1.1e-256 892.1 Bacilli trpE GO:0000162,GO:0003674,GO:0003824,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQAP@1239,4HB31@91061,COG0147@1,COG0147@2 NA|NA|NA EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia HLLCKODE_01293 322159.STER_1555 8.4e-39 166.0 Bacteria pchB 2.5.1.19,4.2.1.10,4.2.99.21,5.4.99.5 ko:K00800,ko:K03785,ko:K04092,ko:K04782 ko00400,ko01053,ko01100,ko01110,ko01130,ko01230,map00400,map01053,map01100,map01110,map01130,map01230 M00022,M00024,M00025 R01715,R03084,R03460,R06602 RC00350,RC00848,RC01549,RC02148,RC03116 ko00000,ko00001,ko00002,ko01000 Bacteria COG1605@1,COG1605@2 NA|NA|NA E Chorismate mutase HLLCKODE_01294 861455.HMPREF9184_00157 0.0 1402.1 Bacteria Bacteria COG0553@1,COG0553@2,COG1502@1,COG1502@2 NA|NA|NA L helicase activity HLLCKODE_01295 435842.HMPREF0848_01018 6.4e-190 669.8 Bacilli nss Bacteria 1V6NM@1239,4HISP@91061,COG0438@1,COG0438@2 NA|NA|NA M transferase activity, transferring glycosyl groups HLLCKODE_01296 585203.SMSK564_1819 3.6e-16 90.5 Streptococcus mitis Bacteria 1U4K0@1239,2DKDD@1,2TQ0I@28037,3097M@2,4IEBR@91061 NA|NA|NA S Accessory secretory protein Sec, Asp5 HLLCKODE_01297 1008453.HMPREF9957_1677 2.6e-17 94.0 Streptococcus mitis Bacteria 1U4KE@1239,2AHFC@1,2TQ11@28037,317SM@2,4IEC5@91061 NA|NA|NA S Accessory secretory protein Sec Asp4 HLLCKODE_01298 904306.HMPREF9192_1018 9.7e-242 842.4 Bacilli gtf2 Bacteria 1TQZR@1239,4HEYJ@91061,COG0438@1,COG0438@2 NA|NA|NA M A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1 HLLCKODE_01299 904306.HMPREF9192_1017 1.4e-278 964.9 Bacilli gtf1 2.4.1.52 ko:K00712 ko00000,ko01000,ko01003 GT4 Bacteria 1TR6K@1239,4HGDG@91061,COG0438@1,COG0438@2 NA|NA|NA M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon HLLCKODE_01300 435842.HMPREF0848_01023 0.0 1521.1 Bacilli secA2 ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 Bacteria 1TRJA@1239,4HCH0@91061,COG0653@1,COG0653@2 NA|NA|NA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane HLLCKODE_01301 904306.HMPREF9192_1015 5e-78 297.0 Bacilli asp3 ko:K12270 ko00000,ko02044 3.A.5.10 Bacteria 1V6D1@1239,2AFSZ@1,315V3@2,4HS4W@91061 NA|NA|NA S Accessory Sec system protein Asp3 HLLCKODE_01302 904306.HMPREF9192_1014 1.9e-289 1001.1 Bacilli asp2 3.4.11.5 ko:K01259,ko:K06889,ko:K12269 ko00330,map00330 R00135 ko00000,ko00001,ko01000,ko01002,ko02044 3.A.5.10 Bacteria 1TSWW@1239,4HB1I@91061,COG1073@1,COG1073@2 NA|NA|NA S Accessory Sec system protein Asp2 HLLCKODE_01303 904306.HMPREF9192_1013 3.6e-288 996.9 Bacilli asp1 ko:K12268 ko00000,ko02044 3.A.5.10 Bacteria 1V1BC@1239,2CI7G@1,2ZBRM@2,4HKRQ@91061 NA|NA|NA S Accessory Sec system protein Asp1 HLLCKODE_01304 435842.HMPREF0848_01027 1.6e-211 741.9 Bacilli secY2 ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5 Bacteria 1V59T@1239,4HH1U@91061,COG0201@1,COG0201@2 NA|NA|NA U Part of the accessory SecA2 SecY2 system specifically required for export of HLLCKODE_01305 264199.stu1392 0.0 1367.4 Bacilli Bacteria 1VATJ@1239,4HG1M@91061,COG1216@1,COG1216@2,COG1442@1,COG1442@2 NA|NA|NA M family 8 HLLCKODE_01306 1046629.Ssal_01268 2.7e-277 960.7 Bacilli pyk GO:0001871,GO:0003674,GO:0003824,GO:0004743,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006116,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009266,GO:0009408,GO:0009628,GO:0009986,GO:0009987,GO:0016043,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0019693,GO:0019752,GO:0022607,GO:0030246,GO:0030247,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:2001065 2.7.1.40,2.7.7.4 ko:K00873,ko:K00958 ko00010,ko00230,ko00261,ko00450,ko00620,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00261,map00450,map00620,map00920,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050,M00176,M00596 R00200,R00430,R00529,R01138,R01858,R02320,R04929 RC00002,RC00015,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 iECO103_1326.ECO103_1819,iPC815.YPO2393 Bacteria 1TPGG@1239,4H9VY@91061,COG0469@1,COG0469@2 NA|NA|NA G Belongs to the pyruvate kinase family HLLCKODE_01307 1046629.Ssal_01270 3.6e-188 664.1 Bacilli pfkA GO:0003674,GO:0003824,GO:0003872,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006116,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008443,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019200,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046835,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061615,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.11 ko:K00850 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 iYO844.BSU29190 Bacteria 1TPF4@1239,4HAPN@91061,COG0205@1,COG0205@2 NA|NA|NA F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis HLLCKODE_01308 1046629.Ssal_01271 0.0 1998.8 Bacilli dnaE 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 1TPYG@1239,4H9T3@91061,COG0587@1,COG0587@2 NA|NA|NA L DNA polymerase HLLCKODE_01309 1046629.Ssal_00505 9.5e-85 320.5 Bacteria yfjR GO:0008150,GO:0043900,GO:0050789,GO:0050794,GO:0065007,GO:1900190 Bacteria COG2378@1,COG2378@2 NA|NA|NA K regulation of single-species biofilm formation HLLCKODE_01312 365659.smi_0701 4.7e-185 653.7 Streptococcus mitis ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TP1N@1239,2TP7I@28037,4H9NR@91061,COG4586@1,COG4586@2 NA|NA|NA S AAA domain, putative AbiEii toxin, Type IV TA system HLLCKODE_01313 1005705.HMPREF9967_1430 9e-142 509.6 Streptococcus infantis ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TSAN@1239,43FGB@68892,4HBVU@91061,COG4587@1,COG4587@2 NA|NA|NA S ABC-2 family transporter protein HLLCKODE_01314 469609.HMPREF0847_01708 5.6e-141 506.9 Bacilli ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1US4C@1239,4IRS2@91061,COG3694@1,COG3694@2 NA|NA|NA S ABC-2 family transporter protein HLLCKODE_01315 435842.HMPREF0848_00885 8.8e-78 296.2 Bacilli Bacteria 1UI2W@1239,4ISXQ@91061,COG0454@1,COG0456@2 NA|NA|NA K Acetyltransferase (GNAT) domain HLLCKODE_01316 904306.HMPREF9192_1107 0.0 3840.8 Bacilli prtA 3.2.1.23 ko:K01190,ko:K07004,ko:K13277 ko00052,ko00511,ko00600,ko01100,ko02024,map00052,map00511,map00600,map01100,map02024 R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000,ko01002,ko03110 Bacteria 1TPH1@1239,4HBQH@91061,COG1404@1,COG1404@2 NA|NA|NA O Belongs to the peptidase S8 family HLLCKODE_01317 764298.STRMA_1799 2.5e-56 226.5 Bacilli Bacteria 1VX2D@1239,2C4MM@1,340I6@2,4HWVM@91061 NA|NA|NA HLLCKODE_01318 1123311.KB904465_gene1060 2.2e-83 315.5 Bacilli ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 1VR4S@1239,4HUU8@91061,COG1136@1,COG1136@2 NA|NA|NA V ABC transporter HLLCKODE_01319 170187.SP_1343 7.1e-129 468.0 Streptococcus pneumoniae 3.4.21.83 ko:K01354 ko05142,ko05143,map05142,map05143 ko00000,ko00001,ko01000,ko01002 Bacteria 1VE13@1239,1WUKI@1313,4HN6K@91061,COG1770@1,COG1770@2 NA|NA|NA E Prolyl oligopeptidase family HLLCKODE_01320 40041.SZO_05110 2.9e-266 924.9 Streptococcus dysgalactiae group Bacteria 1M9U8@119603,1TSH3@1239,4HGIJ@91061,COG0515@1,COG0515@2 NA|NA|NA KLT Protein kinase domain HLLCKODE_01321 663952.SDD27957_08195 4.8e-139 501.5 Streptococcus dysgalactiae group ko:K06148 ko00000,ko02000 3.A.1 Bacteria 1M9ZI@119603,1UZ1P@1239,4HFI5@91061,COG1132@1,COG1132@2 NA|NA|NA P ABC transporter transmembrane region HLLCKODE_01323 435842.HMPREF0848_00199 2.4e-32 145.6 Bacilli Bacteria 1V3H6@1239,4HIC4@91061,COG1309@1,COG1309@2 NA|NA|NA K Transcriptional regulator C-terminal region HLLCKODE_01324 861455.HMPREF9184_00155 1.5e-271 941.8 Bacilli dcm 2.1.1.37 ko:K00558,ko:K07486 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 Bacteria 1TSNX@1239,4HFAI@91061,COG0270@1,COG0270@2 NA|NA|NA L Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family HLLCKODE_01325 1046629.Ssal_00451 3.2e-57 227.6 Bacilli Bacteria 1VCIA@1239,2C4MC@1,32RSW@2,4HKKA@91061 NA|NA|NA HLLCKODE_01326 904306.HMPREF9192_0784 0.0 1465.7 Bacilli ctpE ko:K12952 ko00000,ko01000 3.A.3.23 Bacteria 1TPF5@1239,4H9ZI@91061,COG0474@1,COG0474@2 NA|NA|NA P E1-E2 ATPase HLLCKODE_01327 537007.BLAHAN_04509 1.5e-26 125.9 Blautia 3.2.1.26 ko:K01193 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00801,R00802,R02410,R03635,R03921,R06088 RC00028,RC00077 ko00000,ko00001,ko01000 GH32 Bacteria 1TPAE@1239,247UU@186801,3XYR0@572511,COG1621@1,COG1621@2 NA|NA|NA G Psort location Cytoplasmic, score HLLCKODE_01328 1046629.Ssal_01523 1.9e-187 661.8 Bacilli Bacteria 1TPFS@1239,4H9V9@91061,COG3039@1,COG3039@2 NA|NA|NA L Transposase HLLCKODE_01329 1046629.Ssal_01528 2.4e-195 688.0 Bacilli pepQ 3.4.13.9 ko:K01271 ko00000,ko01000,ko01002 Bacteria 1TQ6R@1239,4HA5I@91061,COG0006@1,COG0006@2 NA|NA|NA E Belongs to the peptidase M24B family HLLCKODE_01330 1046629.Ssal_01526 2.4e-181 641.3 Bacilli ccpA GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 ko:K02529 ko00000,ko03000 Bacteria 1TQ7K@1239,4H9NG@91061,COG1609@1,COG1609@2 NA|NA|NA K Catabolite control protein A HLLCKODE_01331 1046629.Ssal_01525 1.6e-199 701.8 Bacilli yyaQ Bacteria 1V4K7@1239,4HP2K@91061,COG2315@1,COG2315@2 NA|NA|NA S YjbR HLLCKODE_01332 1046629.Ssal_01524 9e-193 679.5 Firmicutes glxK 2.7.1.165 ko:K00865 ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130 R08572 RC00002,RC00428 ko00000,ko00001,ko01000 Bacteria 1TPSI@1239,COG1929@1,COG1929@2 NA|NA|NA G Belongs to the glycerate kinase type-1 family HLLCKODE_01333 1046629.Ssal_01522 3.1e-75 287.7 Bacilli yueI Bacteria 1VFCV@1239,4HNNE@91061,COG5506@1,COG5506@2 NA|NA|NA S Protein of unknown function (DUF1694) HLLCKODE_01334 1046629.Ssal_01521 7.4e-247 859.4 Bacilli eno GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005518,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0009986,GO:0016829,GO:0016835,GO:0016836,GO:0019899,GO:0030312,GO:0035375,GO:0043236,GO:0044424,GO:0044464,GO:0044877,GO:0050840,GO:0071944 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 Bacteria 1TP2S@1239,4HAKI@91061,COG0148@1,COG0148@2 NA|NA|NA G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis HLLCKODE_01335 1046629.Ssal_00039 2e-36 157.9 Firmicutes Bacteria 1TQ93@1239,COG3464@1,COG3464@2 NA|NA|NA L Transposase HLLCKODE_01336 1005704.HMPREF9968_1465 4.5e-310 1069.7 Streptococcus oralis sfcA 1.1.1.38,4.1.1.101 ko:K00027,ko:K22212 ko00620,ko01120,ko01200,ko02020,map00620,map01120,map01200,map02020 R00214,R11074 RC00105,RC00282 ko00000,ko00001,ko01000 Bacteria 1TPJ3@1239,1WQ0I@1303,4HBF1@91061,COG0281@1,COG0281@2 NA|NA|NA C Malic enzyme, NAD binding domain HLLCKODE_01337 585202.SMSK321_1114 4.8e-163 580.5 Streptococcus mitis mleP ko:K07088 ko00000 Bacteria 1UY4N@1239,2TPIA@28037,4HDX5@91061,COG0679@1,COG0679@2 NA|NA|NA S Sodium Bile acid symporter family HLLCKODE_01338 585204.SMSK597_1523 0.0 1484.2 Streptococcus mitis mprF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.3.2.3 ko:K07027,ko:K14205 ko01503,ko02020,ko05150,map01503,map02020,map05150 M00726 ko00000,ko00001,ko00002,ko01000,ko01504,ko02000 2.A.1.3.37,4.D.2 iYO844.BG12900 Bacteria 1TQI2@1239,2TQ66@28037,4HBHU@91061,COG0392@1,COG0392@2,COG2898@1,COG2898@2 NA|NA|NA S Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms HLLCKODE_01342 1046629.Ssal_01817 2e-161 575.1 Bacilli ppaC GO:0003674,GO:0003824,GO:0004427,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006793,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0044237,GO:0044424,GO:0044464 3.6.1.1 ko:K15986 ko00190,map00190 ko00000,ko00001,ko01000 Bacteria 1TPH6@1239,4H9T8@91061,COG1227@1,COG1227@2 NA|NA|NA C inorganic pyrophosphatase HLLCKODE_01343 1046629.Ssal_01816 1.5e-101 375.6 Bacilli Bacteria 1W4V4@1239,2F8BM@1,340QP@2,4HR72@91061 NA|NA|NA S Domain of unknown function (DUF1803) HLLCKODE_01344 1046629.Ssal_01815 7.8e-102 376.3 Bacilli ygaC ko:K07586 ko00000 Bacteria 1TRX8@1239,4H9NM@91061,COG3557@1,COG3557@2 NA|NA|NA J Belongs to the UPF0374 family HLLCKODE_01345 1046629.Ssal_01814 2.3e-134 485.0 Bacilli recX GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0019899,GO:0031668,GO:0033554,GO:0043086,GO:0044092,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496 2.4.1.337 ko:K03565,ko:K19002 ko00561,ko01100,map00561,map01100 R10850 RC00005,RC00059 ko00000,ko00001,ko01000,ko01003,ko03400 GT4 Bacteria 1V72V@1239,4HKE3@91061,COG2137@1,COG2137@2 NA|NA|NA S Regulatory protein RecX HLLCKODE_01346 1046629.Ssal_01813 4.5e-247 860.1 Bacilli rumA 2.1.1.190,2.1.1.35 ko:K00557,ko:K03215 ko00000,ko01000,ko03009,ko03016 Bacteria 1TP4H@1239,4HA6M@91061,COG2265@1,COG2265@2 NA|NA|NA J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family HLLCKODE_01347 1046629.Ssal_01812 1.4e-192 678.7 Bacilli asnA GO:0003674,GO:0003824,GO:0004071,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006529,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009987,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.1.1 ko:K01914 ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230 R00483 RC00010 ko00000,ko00001,ko01000 iAPECO1_1312.APECO1_2719,iECOK1_1307.ECOK1_4193,iECS88_1305.ECS88_4166,iUMN146_1321.UM146_18910,iUTI89_1310.UTI89_C4299 Bacteria 1TP28@1239,4HAEC@91061,COG2502@1,COG2502@2 NA|NA|NA E aspartate--ammonia ligase HLLCKODE_01350 904306.HMPREF9192_0808 2.9e-254 884.0 Bacilli murF 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 Bacteria 1VT78@1239,4HACR@91061,COG0770@1,COG0770@2 NA|NA|NA M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein HLLCKODE_01351 1046629.Ssal_00479 3.3e-118 431.0 Bacteria ywaF Bacteria COG5522@1,COG5522@2 NA|NA|NA S Integral membrane protein (intg_mem_TP0381) HLLCKODE_01353 1046629.Ssal_00481 2.3e-300 1037.3 Bacilli prfC GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016150,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02837,ko:K07133 ko00000,ko03012 Bacteria 1TPYT@1239,4HADS@91061,COG4108@1,COG4108@2 NA|NA|NA J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP HLLCKODE_01354 322159.STER_1531 1.1e-196 692.6 Bacilli yjbB ko:K08220 ko00000,ko02000 2.A.1.28.1,2.A.1.28.4 Bacteria 1TR4D@1239,4HDCY@91061,COG2211@1,COG2211@2 NA|NA|NA G Permeases of the major facilitator superfamily HLLCKODE_01355 264199.stu1572 5.2e-156 557.0 Bacilli Z012_04635 Bacteria 1UZI0@1239,4HC2C@91061,COG1396@1,COG1396@2 NA|NA|NA K Transcriptional activator, Rgg GadR MutR family HLLCKODE_01356 1046629.Ssal_00485 3.1e-96 357.8 Bacilli thiT ko:K16789 ko00000,ko02000 2.A.88.3 Bacteria 1V6YE@1239,4HIJE@91061,COG3859@1,COG3859@2 NA|NA|NA S Thiamine transporter HLLCKODE_01357 435842.HMPREF0848_01188 2.5e-62 244.6 Bacilli yjqA Bacteria 1V77G@1239,3172B@2,4HJ0W@91061,arCOG12631@1 NA|NA|NA S Bacterial PH domain HLLCKODE_01358 1046629.Ssal_00487 3.1e-151 541.2 Bacilli corA ko:K03284 ko00000,ko02000 1.A.35.1,1.A.35.3 Bacteria 1TPI8@1239,4HCQ6@91061,COG0598@1,COG0598@2 NA|NA|NA P CorA-like protein HLLCKODE_01359 435842.HMPREF0848_01186 1.7e-258 898.3 Bacilli cshA GO:0000166,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0008026,GO:0008144,GO:0008150,GO:0008152,GO:0008186,GO:0009266,GO:0009295,GO:0009409,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901363 3.6.4.13 ko:K05592 ko03018,map03018 ko00000,ko00001,ko01000,ko03009,ko03019 Bacteria 1TPAP@1239,4HAB3@91061,COG0513@1,COG0513@2 NA|NA|NA JKL DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity HLLCKODE_01360 435842.HMPREF0848_01185 3.9e-41 173.7 Bacilli yazA ko:K07461 ko00000 Bacteria 1VEZF@1239,4HNHJ@91061,COG2827@1,COG2827@2 NA|NA|NA L endonuclease containing a URI domain HLLCKODE_01361 1046629.Ssal_00490 9.2e-125 453.0 Bacilli yabB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464 2.1.1.223 ko:K07461,ko:K15460 ko00000,ko01000,ko03016 Bacteria 1TQ25@1239,4HA8W@91061,COG4123@1,COG4123@2 NA|NA|NA L Methyltransferase HLLCKODE_01362 904306.HMPREF9192_0822 4e-154 550.8 Bacilli nodB3 Bacteria 1TYRH@1239,4HIXK@91061,COG0726@1,COG0726@2 NA|NA|NA G Polysaccharide deacetylase HLLCKODE_01363 264199.stu1563 9.2e-141 506.1 Bacilli plsC GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008374,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0042171,GO:0044464,GO:0071617,GO:0071944 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 1U8N2@1239,4HDQR@91061,COG0204@1,COG0204@2 NA|NA|NA I Acyltransferase HLLCKODE_01364 1046629.Ssal_00493 4.9e-88 330.9 Bacilli comEA ko:K02237 M00429 ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 Bacteria 1VA3W@1239,4HKJ1@91061,COG1555@1,COG1555@2 NA|NA|NA L COG1555 DNA uptake protein and related DNA-binding proteins HLLCKODE_01365 1046629.Ssal_00495 0.0 1392.1 Bacilli comEC ko:K02238 M00429 ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 Bacteria 1TS9U@1239,4H9M4@91061,COG0658@1,COG0658@2,COG2333@1,COG2333@2 NA|NA|NA S Competence protein ComEC HLLCKODE_01366 1046629.Ssal_00497 5.5e-231 806.6 Bacilli murA GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008760,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016765,GO:0030203,GO:0034645,GO:0042221,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0070589,GO:0070887,GO:0071236,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 R00660 RC00350 ko00000,ko00001,ko01000,ko01011 iYO844.BSU37100 Bacteria 1TPAU@1239,4H9KI@91061,COG0766@1,COG0766@2 NA|NA|NA M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine HLLCKODE_01367 1046629.Ssal_00498 2.8e-99 367.9 Bacilli XK27_07830 2.3.1.128 ko:K03790 ko00000,ko01000,ko03009 Bacteria 1V576@1239,4HH6U@91061,COG1670@1,COG1670@2 NA|NA|NA J Acetyltransferase GNAT Family HLLCKODE_01368 1046629.Ssal_00499 1.5e-231 808.5 Bacilli ytoI Bacteria 1TPU6@1239,4HB62@91061,COG4109@1,COG4109@2 NA|NA|NA K transcriptional regulator containing CBS domains HLLCKODE_01369 1046629.Ssal_00500 1.1e-166 592.4 Bacilli map GO:0000096,GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006508,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009066,GO:0009987,GO:0010467,GO:0016151,GO:0016485,GO:0016787,GO:0019538,GO:0019752,GO:0030145,GO:0035551,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050897,GO:0051604,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0140096,GO:1901564,GO:1901605 3.4.11.18 ko:K01265 ko00000,ko01000,ko01002 Bacteria 1TQC1@1239,4H9S9@91061,COG0024@1,COG0024@2 NA|NA|NA E Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed HLLCKODE_01370 1046629.Ssal_00501 2.8e-163 581.3 Bacilli rbn ko:K07058 ko00000 Bacteria 1U7HM@1239,4H9MJ@91061,COG1295@1,COG1295@2 NA|NA|NA E Belongs to the UPF0761 family HLLCKODE_01371 1046629.Ssal_00502 1.7e-85 322.0 Bacilli ccl GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 1V22G@1239,4HGG2@91061,COG4708@1,COG4708@2 NA|NA|NA S cog cog4708 HLLCKODE_01372 904306.HMPREF9192_0832 0.0 1233.0 Bacilli ligA GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 Bacteria 1TPQ3@1239,4HA1D@91061,COG0272@1,COG0272@2 NA|NA|NA L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA HLLCKODE_01373 1046629.Ssal_00504 9e-184 649.4 Bacilli yegS GO:0001727,GO:0003674,GO:0003824,GO:0004143,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0030258,GO:0044237,GO:0044238,GO:0044255,GO:0046834,GO:0071704 2.7.1.107 ko:K07029 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 R02240 RC00002,RC00017 ko00000,ko00001,ko01000 Bacteria 1TQAU@1239,4H9WD@91061,COG1597@1,COG1597@2 NA|NA|NA I Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase HLLCKODE_01375 1046629.Ssal_00505 5.7e-175 620.2 Bacteria yfjR GO:0008150,GO:0043900,GO:0050789,GO:0050794,GO:0065007,GO:1900190 Bacteria COG2378@1,COG2378@2 NA|NA|NA K regulation of single-species biofilm formation HLLCKODE_01377 1046629.Ssal_00507 3.7e-71 274.2 Bacilli Bacteria 1V99E@1239,4HXAN@91061,COG4708@1,COG4708@2 NA|NA|NA S QueT transporter HLLCKODE_01378 1046629.Ssal_00508 1e-156 559.3 Bacilli xth GO:0003674,GO:0003824,GO:0003906,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008296,GO:0008309,GO:0008311,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.11.2 ko:K01142 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 1TPFB@1239,4HAIU@91061,COG0708@1,COG0708@2 NA|NA|NA L exodeoxyribonuclease III HLLCKODE_01380 1095727.HMPREF1117_1254 3.7e-17 95.5 Bacilli yjdB Bacteria 1VFT3@1239,2DMBI@1,32H42@2,4HK1A@91061 NA|NA|NA S Domain of unknown function (DUF4767) HLLCKODE_01381 435842.HMPREF0848_01163 2.1e-165 588.2 Bacilli tehB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0010035,GO:0016740,GO:0016741,GO:0032259,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0046690,GO:0050896 2.1.1.265 ko:K03647,ko:K16868 ko00000,ko01000 Bacteria 1TSZK@1239,4HJT1@91061,COG0500@1,COG0500@2,COG3615@1,COG3615@2 NA|NA|NA PQ tellurite resistance protein tehb HLLCKODE_01383 1046629.Ssal_00513 8.5e-161 573.5 Bacteria Bacteria COG5549@1,COG5549@2 NA|NA|NA O protein import HLLCKODE_01384 1046629.Ssal_00514 4.2e-122 444.1 Bacteria agrA ko:K07707 ko02020,ko02024,map02020,map02024 M00495 ko00000,ko00001,ko00002,ko02022 Bacteria COG3279@1,COG3279@2 NA|NA|NA KT phosphorelay signal transduction system HLLCKODE_01385 435842.HMPREF0848_01160 1.7e-211 741.9 Bacteria 2.7.13.3 ko:K07706 ko02020,ko02024,map02020,map02024 M00495 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria COG3290@1,COG3290@2 NA|NA|NA T protein histidine kinase activity HLLCKODE_01387 1046629.Ssal_00517 2.4e-43 181.0 Bacilli rpsP GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02959 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011,ko03029 Bacteria 1VA0X@1239,4HKNN@91061,COG0228@1,COG0228@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bS16 family HLLCKODE_01388 1046629.Ssal_00518 1.5e-36 158.3 Bacteria ylqC ko:K06960 ko00000 Bacteria COG1837@1,COG1837@2 NA|NA|NA L Belongs to the UPF0109 family HLLCKODE_01389 1046629.Ssal_00519 1e-232 812.4 Bacilli folC 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0166 Bacteria 1TPX5@1239,4HBJM@91061,COG0285@1,COG0285@2 NA|NA|NA H Belongs to the folylpolyglutamate synthase family HLLCKODE_01390 1046629.Ssal_00520 0.0 1168.7 Bacilli ydaO GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015179,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015807,GO:0015849,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1902475,GO:1903825,GO:1905039 Bacteria 1TQE1@1239,4HAZH@91061,COG0531@1,COG0531@2 NA|NA|NA E amino acid HLLCKODE_01391 1046629.Ssal_00521 2.2e-99 368.2 Bacilli folE GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv3609c Bacteria 1TRNM@1239,4HAXS@91061,COG0302@1,COG0302@2 NA|NA|NA F gtp cyclohydrolase HLLCKODE_01392 1046629.Ssal_00522 4.2e-144 517.3 Bacilli folP GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.15,2.7.6.3 ko:K00796,ko:K13941 ko00790,ko01100,map00790,map01100 M00126,M00840,M00841 R03066,R03067,R03503 RC00002,RC00017,RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS03115 Bacteria 1TPKT@1239,4H9SY@91061,COG0294@1,COG0294@2 NA|NA|NA H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives HLLCKODE_01393 435842.HMPREF0848_01152 4e-294 1016.5 Bacilli amy 3.2.1.1 ko:K01176 ko00500,ko01100,ko04973,map00500,map01100,map04973 R02108,R02112,R11262 ko00000,ko00001,ko01000 GH13 Bacteria 1TRKZ@1239,4HC8C@91061,COG0366@1,COG0366@2 NA|NA|NA G Belongs to the glycosyl hydrolase 13 family HLLCKODE_01394 1046629.Ssal_00524 2.9e-60 237.7 Bacilli folB 1.13.11.81,2.5.1.15,2.7.6.3,4.1.2.25,5.1.99.8 ko:K00796,ko:K00950,ko:K01633,ko:K13940 ko00790,ko01100,map00790,map01100 M00126,M00840,M00841 R03066,R03067,R03503,R03504,R11037,R11073 RC00002,RC00017,RC00121,RC00721,RC00842,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 Bacteria 1VA0I@1239,4HKKK@91061,COG1539@1,COG1539@2 NA|NA|NA H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin HLLCKODE_01395 1046629.Ssal_00525 5.5e-78 297.0 Bacilli folK 2.7.6.3,4.1.2.25 ko:K00950,ko:K13940 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503,R03504 RC00002,RC00017,RC00721,RC00943 ko00000,ko00001,ko00002,ko01000 Bacteria 1V6PR@1239,4HIMG@91061,COG0801@1,COG0801@2 NA|NA|NA H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HLLCKODE_01396 1046629.Ssal_00526 5.8e-166 590.1 Bacilli murB 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 Bacteria 1TP3W@1239,4HAD8@91061,COG0812@1,COG0812@2 NA|NA|NA M cell wall formation HLLCKODE_01397 904306.HMPREF9192_0862 5.2e-212 743.4 Bacilli potA 3.6.3.30,3.6.3.31 ko:K02010,ko:K11072 ko02010,map02010 M00190,M00299 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10,3.A.1.11.1 iSB619.SA_RS05380 Bacteria 1TP2M@1239,4H9MS@91061,COG3842@1,COG3842@2 NA|NA|NA P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system HLLCKODE_01398 435842.HMPREF0848_01147 1.8e-139 501.9 Bacilli potB ko:K11071 ko02010,map02010 M00299 ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 Bacteria 1TQ7Z@1239,4HAYS@91061,COG1176@1,COG1176@2 NA|NA|NA P ABC-type spermidine putrescine transport system, permease component I HLLCKODE_01399 1046629.Ssal_00529 2.3e-131 474.9 Bacilli potC GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008519,GO:0015075,GO:0015101,GO:0015203,GO:0015399,GO:0015405,GO:0015417,GO:0015595,GO:0015606,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0015848,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072488,GO:0098533,GO:0098655,GO:0098796,GO:0098797,GO:1902047,GO:1902494,GO:1902495,GO:1903711,GO:1904949,GO:1990351 ko:K11070 ko02010,map02010 M00299 ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 iSBO_1134.SBO_1939 Bacteria 1V0VD@1239,4H9ZC@91061,COG1177@1,COG1177@2 NA|NA|NA P ABC-type spermidine putrescine transport system, permease component II HLLCKODE_01400 1046629.Ssal_00530 1.7e-204 718.4 Bacilli potD ko:K11069 ko02010,map02010 M00299 ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 iSB619.SA_RS05395 Bacteria 1TPY1@1239,4HAET@91061,COG0687@1,COG0687@2 NA|NA|NA P spermidine putrescine ABC transporter HLLCKODE_01401 1046629.Ssal_00531 1.9e-145 521.9 Bacilli XK27_08050 Bacteria 1TPXU@1239,4HGRC@91061,COG0330@1,COG0330@2 NA|NA|NA O HflC and HflK could regulate a protease HLLCKODE_01402 904306.HMPREF9192_0869 1.8e-71 275.0 Bacilli gloA 4.4.1.5 ko:K01759,ko:K15772 ko00620,ko02010,map00620,map02010 M00491 R02530 RC00004,RC00740 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.1.16,3.A.1.1.2 Bacteria 1V6K3@1239,4HJ7X@91061,COG0346@1,COG0346@2 NA|NA|NA E Lactoylglutathione lyase HLLCKODE_01403 1046629.Ssal_00536 2e-158 565.1 Bacilli Bacteria 1TRQ7@1239,4HE30@91061,COG1940@1,COG1940@2 NA|NA|NA GK ROK family HLLCKODE_01404 1046629.Ssal_00537 1.9e-208 731.5 Bacilli serC GO:0003674,GO:0003824,GO:0004648,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 1TP6Y@1239,4HATT@91061,COG1932@1,COG1932@2 NA|NA|NA E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine HLLCKODE_01405 904306.HMPREF9192_0872 3.1e-101 374.4 Bacilli wecD Bacteria 1UIW7@1239,4ISU9@91061,COG1247@1,COG1247@2 NA|NA|NA M Acetyltransferase (GNAT) domain HLLCKODE_01406 1046629.Ssal_00539 1.3e-218 765.4 Bacilli serA 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1V410@1239,4H9PH@91061,COG0111@1,COG0111@2 NA|NA|NA EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family HLLCKODE_01407 904306.HMPREF9192_0874 6.3e-74 283.5 Bacteria ogt GO:0003674,GO:0003824,GO:0003908,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 2.1.1.63,3.2.2.20 ko:K00567,ko:K01246 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria COG0350@1,COG0350@2 NA|NA|NA L methylated-DNA-[protein]-cysteine S-methyltransferase activity HLLCKODE_01408 1046629.Ssal_01688 1.6e-58 231.9 Bacilli arsC 1.20.4.1 ko:K00537,ko:K16509 ko00000,ko01000 Bacteria 1VA5Q@1239,4HKQQ@91061,COG1393@1,COG1393@2 NA|NA|NA P Belongs to the ArsC family HLLCKODE_01410 435842.HMPREF0848_01131 1e-55 222.6 Firmicutes lrgA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K06518 ko00000,ko02000 1.E.14.2 Bacteria 1VEN4@1239,COG1380@1,COG1380@2 NA|NA|NA S Effector of murein hydrolase LrgA HLLCKODE_01411 904306.HMPREF9192_0878 3.2e-116 424.5 Firmicutes lrgB Bacteria 1TRGN@1239,COG1346@1,COG1346@2 NA|NA|NA M Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like proteins CidA and or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses HLLCKODE_01412 1046629.Ssal_00557 1.2e-97 362.5 Bacilli 3.1.3.18 ko:K01091,ko:K07025 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 R01334 RC00017 ko00000,ko00001,ko01000 Bacteria 1V421@1239,4HHYH@91061,COG0546@1,COG0546@2 NA|NA|NA S IA, variant 1 HLLCKODE_01413 1046629.Ssal_00558 0.0 1274.6 Bacilli gyrB GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 5.99.1.3 ko:K02470,ko:K02622 ko00000,ko01000,ko02048,ko03032,ko03036,ko03400 Bacteria 1TQ0R@1239,4H9Y6@91061,COG0187@1,COG0187@2 NA|NA|NA L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner HLLCKODE_01414 1046629.Ssal_00559 1.9e-298 1031.2 Bacilli ezrA GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0000918,GO:0000921,GO:0005575,GO:0005623,GO:0005886,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0022402,GO:0022607,GO:0031106,GO:0032185,GO:0032506,GO:0034622,GO:0043933,GO:0044085,GO:0044464,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051301,GO:0051302,GO:0051781,GO:0061640,GO:0065003,GO:0065007,GO:0070925,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047 ko:K06286,ko:K07158 ko00000,ko03036 Bacteria 1TQR7@1239,4HA15@91061,COG4477@1,COG4477@2 NA|NA|NA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization HLLCKODE_01415 1046629.Ssal_00560 2.5e-110 404.8 Bacilli serB 3.1.3.3 ko:K01079 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R00582 RC00017 ko00000,ko00001,ko00002,ko01000,ko01009 Bacteria 1V9R7@1239,4HTNE@91061,COG0560@1,COG0560@2 NA|NA|NA E phosphoserine phosphatase HLLCKODE_01416 1123300.AUIN01000016_gene627 6.5e-08 63.2 Bacteria Bacteria COG1598@1,COG1598@2 NA|NA|NA N PFAM Uncharacterised protein family UPF0150 HLLCKODE_01417 1046629.Ssal_00562 1.7e-149 535.4 Firmicutes Bacteria 1TYSF@1239,COG0697@1,COG0697@2 NA|NA|NA EG Permeases of the drug metabolite transporter (DMT) superfamily HLLCKODE_01419 1046629.Ssal_00565 1.3e-60 238.8 Bacteria ycaO ko:K06889,ko:K07397,ko:K09136 ko00000,ko03009 Bacteria COG1765@1,COG1765@2 NA|NA|NA O OsmC-like protein HLLCKODE_01420 264199.stu1516 1.9e-62 245.0 Bacilli paaI ko:K02614 ko00360,map00360 R09840 RC00004,RC00014 ko00000,ko00001,ko01000 Bacteria 1VN0K@1239,4HM66@91061,COG2050@1,COG2050@2 NA|NA|NA Q protein possibly involved in aromatic compounds catabolism HLLCKODE_01421 1141106.CAIB01000144_gene1221 9.8e-10 71.2 Bacilli Bacteria 1V7HC@1239,4HVUS@91061,COG1397@1,COG1397@2 NA|NA|NA O ADP-ribosylglycohydrolase HLLCKODE_01422 1046629.Ssal_00568 8.1e-126 456.4 Bacilli rsuA GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.19,5.4.99.22 ko:K06178,ko:K06183 ko00000,ko01000,ko03009 Bacteria 1TQZ2@1239,4H9VU@91061,COG1187@1,COG1187@2 NA|NA|NA J Belongs to the pseudouridine synthase RsuA family HLLCKODE_01424 904306.HMPREF9192_0893 3.3e-247 860.5 Bacilli obg GO:0000003,GO:0000160,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019954,GO:0023052,GO:0030436,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035556,GO:0035639,GO:0036094,GO:0043021,GO:0043022,GO:0043167,GO:0043168,GO:0043934,GO:0044424,GO:0044464,GO:0044877,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0097159,GO:0097367,GO:1901265,GO:1901363 ko:K03979 ko00000,ko01000,ko03009 Bacteria 1TPX7@1239,4H9P8@91061,COG0536@1,COG0536@2 NA|NA|NA S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HLLCKODE_01425 1321372.AQQB01000060_gene15 1.7e-17 94.7 Streptococcus suis XK27_00735 Bacteria 1U94Q@1239,1WTRS@1307,29R2M@1,30C3R@2,4IJ5T@91061 NA|NA|NA HLLCKODE_01426 1046629.Ssal_00573 8.7e-136 489.6 Bacilli glnQ 3.6.3.21 ko:K02028,ko:K10038 ko02010,map02010 M00227,M00236 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.2 Bacteria 1TNYD@1239,4H9WY@91061,COG1126@1,COG1126@2 NA|NA|NA E abc transporter atp-binding protein HLLCKODE_01427 1046629.Ssal_00574 0.0 1348.6 Bacilli glnP ko:K02029,ko:K02030,ko:K10040,ko:K17073,ko:K17074 ko02010,map02010 M00228,M00236,M00589 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.20 Bacteria 1TQUG@1239,4HAJ5@91061,COG0765@1,COG0765@2,COG0834@1,COG0834@2 NA|NA|NA P ABC-type amino acid transport signal transduction systems periplasmic component domain HLLCKODE_01428 1046629.Ssal_00575 7.3e-164 583.2 Bacilli ko:K07052 ko00000 Bacteria 1VA8S@1239,4IQWI@91061,COG1266@1,COG1266@2 NA|NA|NA S CAAX amino terminal protease family protein HLLCKODE_01430 904306.HMPREF9192_0899 0.0 1282.7 Bacilli uvrB ko:K03702,ko:K08999 ko03420,map03420 ko00000,ko00001,ko03400 Bacteria 1TPKB@1239,4HB81@91061,COG0556@1,COG0556@2 NA|NA|NA L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage HLLCKODE_01431 322159.STER_1456 1.8e-78 298.5 Firmicutes mutT 3.6.1.55 ko:K03574 ko00000,ko01000,ko03400 Bacteria 1V3MM@1239,COG1051@1,COG1051@2 NA|NA|NA F Nudix family HLLCKODE_01432 1046629.Ssal_00582 2.2e-140 505.0 Bacilli ko:K02030,ko:K17073,ko:K17074 ko02010,map02010 M00236,M00589 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.20 Bacteria 1TT16@1239,4HJ2R@91061,COG0834@1,COG0834@2 NA|NA|NA ET ABC transporter HLLCKODE_01433 1046629.Ssal_00583 6.1e-135 486.9 Firmicutes ko:K02030,ko:K17073,ko:K17074 ko02010,map02010 M00236,M00589 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.20 Bacteria 1TT16@1239,COG0834@1,COG0834@2 NA|NA|NA ET Belongs to the bacterial solute-binding protein 3 family HLLCKODE_01434 1046629.Ssal_00584 3.8e-212 743.8 Bacilli arcT 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 Bacteria 1TQPD@1239,4HE7P@91061,COG0436@1,COG0436@2 NA|NA|NA E Aminotransferase HLLCKODE_01435 1046629.Ssal_00585 1e-129 469.5 Bacilli gltS ko:K02030,ko:K17073,ko:K17074 ko02010,map02010 M00236,M00589 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.20 Bacteria 1TT16@1239,4HD16@91061,COG0834@1,COG0834@2 NA|NA|NA ET Belongs to the bacterial solute-binding protein 3 family HLLCKODE_01436 1046629.Ssal_00586 3.2e-20 103.6 Bacilli rpsU GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02970 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1VEHU@1239,4HNPV@91061,COG0828@1,COG0828@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bS21 family HLLCKODE_01437 873449.STRCR_1157 9.9e-51 206.1 Bacilli mscL GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 ko:K03282 ko00000,ko02000 1.A.22.1 Bacteria 1VA14@1239,4HKIA@91061,COG1970@1,COG1970@2 NA|NA|NA M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell HLLCKODE_01438 1046629.Ssal_00588 0.0 1173.7 Bacilli dnaG ko:K02316 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Bacteria 1TQ0X@1239,4HAG2@91061,COG0358@1,COG0358@2 NA|NA|NA L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication HLLCKODE_01439 1046629.Ssal_00589 4e-201 707.2 Bacilli sigA GO:0000988,GO:0000990,GO:0001098,GO:0001101,GO:0001108,GO:0001666,GO:0002791,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009405,GO:0009408,GO:0009410,GO:0009415,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010035,GO:0010468,GO:0010556,GO:0010557,GO:0010565,GO:0010604,GO:0010628,GO:0016020,GO:0016987,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0019899,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032879,GO:0032880,GO:0036293,GO:0040007,GO:0042221,GO:0043175,GO:0043254,GO:0044087,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050708,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051049,GO:0051128,GO:0051171,GO:0051173,GO:0051223,GO:0051252,GO:0051254,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0070063,GO:0070201,GO:0070482,GO:0071944,GO:0080090,GO:0090087,GO:0097159,GO:0140110,GO:1901363,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:1903530,GO:2000112,GO:2000142,GO:2001141 ko:K03086,ko:K03087 ko02026,ko05111,map02026,map05111 ko00000,ko00001,ko03021 Bacteria 1TPD6@1239,4HB1H@91061,COG0568@1,COG0568@2 NA|NA|NA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth HLLCKODE_01440 1046629.Ssal_00591 3.4e-55 220.7 Bacilli yitW ko:K02612 ko00360,ko01120,map00360,map01120 R09838 RC02690 ko00000,ko00001 Bacteria 1V9YV@1239,4HKC6@91061,COG2151@1,COG2151@2 NA|NA|NA K metal-sulfur cluster biosynthetic enzyme HLLCKODE_01441 1046629.Ssal_00592 1.4e-170 605.5 Bacilli yfdH ko:K12999,ko:K20534 ko00000,ko01000,ko01003,ko01005,ko02000 4.D.2.1.9 GT2 Bacteria 1TPR3@1239,4HC2Z@91061,COG0463@1,COG0463@2 NA|NA|NA M COG0463, glycosyltransferases involved in cell wall biogenesis HLLCKODE_01442 904306.HMPREF9192_0913 1.3e-255 888.6 Bacilli Bacteria 1VQBK@1239,2EPWD@1,33HGX@2,4HUQ1@91061 NA|NA|NA S Glucosyl transferase GtrII HLLCKODE_01443 264199.stu1483 1.3e-159 568.9 Bacilli rfbD 1.1.1.133,5.1.3.13 ko:K00067,ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777,R06514 RC00182,RC01531 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP71@1239,4HBXF@91061,COG1091@1,COG1091@2 NA|NA|NA M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose HLLCKODE_01444 904306.HMPREF9192_0915 5.7e-220 770.0 Bacilli amrA Bacteria 1V1RP@1239,4IR8D@91061,COG2244@1,COG2244@2 NA|NA|NA S membrane protein involved in the export of O-antigen and teichoic acid HLLCKODE_01445 904306.HMPREF9192_0916 3.2e-175 620.9 Bacilli Bacteria 1V0TF@1239,4ISVG@91061,COG1215@1,COG1215@2 NA|NA|NA M Glycosyltransferase, group 2 family protein HLLCKODE_01446 322159.STER_1441 4.4e-180 637.1 Bacilli cpsIaJ Bacteria 1V3XP@1239,4HQNP@91061,COG1216@1,COG1216@2 NA|NA|NA S Glycosyltransferase like family 2 HLLCKODE_01447 904306.HMPREF9192_0918 1.9e-127 461.8 Bacilli arnC ko:K00786 ko00000,ko01000 Bacteria 1UHQZ@1239,4IS6R@91061,COG1215@1,COG1215@2 NA|NA|NA M group 2 family protein HLLCKODE_01448 1046629.Ssal_00599 1.6e-42 178.7 Firmicutes ko:K09153 ko00000 Bacteria 1VPQZ@1239,2EVMS@1,33P1S@2 NA|NA|NA S Uncharacterized conserved protein (DUF2304) HLLCKODE_01449 904306.HMPREF9192_0920 2.6e-154 551.2 Firmicutes 2.4.1.60 ko:K07011,ko:K13005 ko00000,ko01000,ko01003,ko01005 Bacteria 1UI19@1239,COG1216@1,COG1216@2 NA|NA|NA S Glycosyltransferase group 2 family protein HLLCKODE_01450 1046629.Ssal_00601 0.0 1892.1 Bacilli rgpF ko:K07272,ko:K20444 ko00000,ko01000,ko01003,ko01005,ko02000 4.D.1.3 GT2,GT4 Bacteria 1UJI4@1239,4HNC8@91061,COG0438@1,COG0438@2,COG1215@1,COG1215@2,COG3754@1,COG3754@2 NA|NA|NA M Glycosyltransferase like family 2 HLLCKODE_01451 904306.HMPREF9192_0922 1.4e-218 765.4 Bacteria Bacteria COG4713@1,COG4713@2 NA|NA|NA M Psort location CytoplasmicMembrane, score HLLCKODE_01452 1046629.Ssal_00603 8.4e-224 782.7 Bacteria ko:K00754 ko00000,ko01000 GT4 Bacteria COG0438@1,COG0438@2 NA|NA|NA M transferase activity, transferring glycosyl groups HLLCKODE_01453 904306.HMPREF9192_0924 1.4e-220 771.9 Bacilli rgpA ko:K12996 ko00000,ko01000,ko01003,ko01005 GT4 Bacteria 1V7K7@1239,4HA9A@91061,COG0438@1,COG0438@2 NA|NA|NA M Domain of unknown function (DUF1972) HLLCKODE_01454 904306.HMPREF9192_0925 3.9e-173 614.0 Bacilli rgpB ko:K12997 ko00000,ko01000,ko01003,ko01005 GT2 Bacteria 1V7IQ@1239,4HK7R@91061,COG0463@1,COG0463@2 NA|NA|NA M Glycosyltransferase, group 2 family protein HLLCKODE_01455 904306.HMPREF9192_0926 9.8e-141 506.1 Firmicutes rgpC ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1V1J2@1239,COG1682@1,COG1682@2 NA|NA|NA GM Transport permease protein HLLCKODE_01456 904306.HMPREF9192_0927 1.8e-223 781.6 Bacilli rgpD 3.6.3.38 ko:K01990,ko:K09689,ko:K09691 ko02010,map02010 M00249,M00250,M00254 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.101,3.A.1.103 Bacteria 1TQKK@1239,4HC6N@91061,COG1134@1,COG1134@2 NA|NA|NA P Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system HLLCKODE_01457 1046629.Ssal_00610 5.4e-279 966.5 Bacteria rgpF ko:K07272 ko00000,ko01000,ko01003,ko01005 Bacteria COG3754@1,COG3754@2 NA|NA|NA M Rhamnan synthesis protein F HLLCKODE_01458 322159.STER_1430 5.3e-111 407.1 Bacilli radC ko:K03630 ko00000 Bacteria 1TQ3K@1239,4HB1W@91061,COG2003@1,COG2003@2 NA|NA|NA E Belongs to the UPF0758 family HLLCKODE_01459 1046629.Ssal_00612 3.2e-132 477.6 Bacilli puuD ko:K07010 ko00000,ko01002 Bacteria 1V1KC@1239,4HI59@91061,COG2071@1,COG2071@2 NA|NA|NA T peptidase C26 HLLCKODE_01460 1046629.Ssal_00613 7.3e-118 429.9 Bacilli rex ko:K01926 ko00000,ko03000 Bacteria 1TSMR@1239,4HB7Q@91061,COG2344@1,COG2344@2 NA|NA|NA K Modulates transcription in response to changes in cellular NADH NAD( ) redox state HLLCKODE_01461 1046629.Ssal_00614 8.2e-60 236.1 Bacilli XK27_04120 Bacteria 1VDSF@1239,2DHWG@1,32U9W@2,4HP9N@91061 NA|NA|NA S Putative amino acid metabolism HLLCKODE_01462 1046629.Ssal_00615 8.3e-207 726.1 Bacilli iscS 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 Bacteria 1TP21@1239,4HA6H@91061,COG1104@1,COG1104@2 NA|NA|NA E Cysteine desulfurase HLLCKODE_01463 1046629.Ssal_00616 8.7e-176 622.9 Bacilli prs 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2848 Bacteria 1TQ4I@1239,4HDRN@91061,COG0462@1,COG0462@2 NA|NA|NA F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) HLLCKODE_01464 904306.HMPREF9192_0936 6e-100 370.2 Bacilli yjbK Bacteria 1VA56@1239,4HMNE@91061,COG4116@1,COG4116@2 NA|NA|NA S Adenylate cyclase HLLCKODE_01465 264199.stu1459 3e-119 434.5 Bacilli yjbM 2.7.6.5 ko:K07816 ko00230,map00230 R00429 RC00002,RC00078 ko00000,ko00001,ko01000 Bacteria 1TQ2F@1239,4HA3Q@91061,COG2357@1,COG2357@2 NA|NA|NA S Gtp pyrophosphokinase HLLCKODE_01466 264199.stu1457 7.5e-152 543.1 Bacilli nadK GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 R00104 RC00002,RC00078 ko00000,ko00001,ko01000 iEcSMS35_1347.EcSMS35_2767,iHN637.CLJU_RS05480,iLJ478.TM1733,iSB619.SA_RS04895 Bacteria 1TRB3@1239,4HB08@91061,COG0061@1,COG0061@2 NA|NA|NA H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP HLLCKODE_01467 264199.stu1456 9.2e-172 609.4 Bacilli rluD GO:0000027,GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022607,GO:0022613,GO:0022618,GO:0031118,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 5.4.99.23,5.4.99.28,5.4.99.29 ko:K06177,ko:K06180 ko00000,ko01000,ko03009,ko03016 iE2348C_1286.E2348C_2868,iECED1_1282.ECED1_3035,iECSF_1327.ECSF_2432 Bacteria 1TS1T@1239,4HBRY@91061,COG0564@1,COG0564@2 NA|NA|NA J Responsible for synthesis of pseudouridine from uracil HLLCKODE_01468 1046629.Ssal_00621 8.8e-176 622.9 Bacilli pta 2.3.1.8,3.6.3.21 ko:K00625,ko:K02028,ko:K13788 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00236,M00357,M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3 iSB619.SA_RS03155 Bacteria 1TPQ0@1239,4H9VH@91061,COG0280@1,COG0280@2 NA|NA|NA C phosphate acetyltransferase HLLCKODE_01469 904306.HMPREF9192_0941 0.0 1216.4 Bacilli amiA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 1TQVS@1239,4HCCB@91061,COG4166@1,COG4166@2 NA|NA|NA E ABC transporter, substrate-binding protein, family 5 HLLCKODE_01470 1046629.Ssal_00622 4.1e-310 1070.1 Bacilli amiA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02035,ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 1TQVS@1239,4HCCB@91061,COG4166@1,COG4166@2 NA|NA|NA E ABC transporter, substrate-binding protein, family 5 HLLCKODE_01471 1046629.Ssal_00624 7.8e-277 959.1 Bacilli amiC GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0022857,GO:0051179,GO:0051234,GO:0055085 ko:K02033,ko:K13894,ko:K15581 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00349,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.21,3.A.1.5.24,3.A.1.5.25 Bacteria 1UY5U@1239,4HEZK@91061,COG0601@1,COG0601@2 NA|NA|NA P ABC transporter (Permease HLLCKODE_01472 1046629.Ssal_00625 3.8e-165 587.4 Bacilli amiD ko:K15582 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 1TP4R@1239,4HE8S@91061,COG1173@1,COG1173@2 NA|NA|NA P ABC transporter (Permease HLLCKODE_01473 904306.HMPREF9192_0944 6e-202 709.9 Bacilli oppD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02031,ko:K02032,ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 1TP6E@1239,4H9MR@91061,COG0444@1,COG0444@2 NA|NA|NA P Belongs to the ABC transporter superfamily HLLCKODE_01474 1046629.Ssal_00627 8e-171 606.3 Bacilli oppF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02032,ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 1V36J@1239,4HCM4@91061,COG4608@1,COG4608@2 NA|NA|NA P Belongs to the ABC transporter superfamily HLLCKODE_01475 1046629.Ssal_00628 3.8e-129 467.6 Firmicutes ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1VF25@1239,COG1131@1,COG1131@2 NA|NA|NA V Psort location CytoplasmicMembrane, score HLLCKODE_01476 1046629.Ssal_00629 3.1e-119 434.5 Bacilli skfE ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TPUP@1239,4HGHM@91061,COG1131@1,COG1131@2 NA|NA|NA V abc transporter atp-binding protein HLLCKODE_01477 904306.HMPREF9192_0948 5.6e-62 243.4 Bacilli yvoA_1 ko:K07979 ko00000,ko03000 Bacteria 1VFD0@1239,4HNIT@91061,COG1725@1,COG1725@2 NA|NA|NA K Transcriptional HLLCKODE_01478 1046629.Ssal_00631 1.4e-147 528.9 Bacilli supH Bacteria 1V2JE@1239,4IPK2@91061,COG0561@1,COG0561@2 NA|NA|NA S overlaps another CDS with the same product name HLLCKODE_01479 1046629.Ssal_00632 2.8e-143 514.6 Bacilli XK27_02985 Bacteria 1TR2E@1239,4HGA9@91061,COG0561@1,COG0561@2 NA|NA|NA S overlaps another CDS with the same product name HLLCKODE_01480 904306.HMPREF9192_0951 4.7e-199 700.7 Bacilli ftsY ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 Bacteria 1TPRI@1239,4HA6A@91061,COG0552@1,COG0552@2 NA|NA|NA U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HLLCKODE_01481 1046629.Ssal_00636 1.2e-112 412.5 Bacilli gmk GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 iYO844.BSU15680 Bacteria 1TP0M@1239,4HAYW@91061,COG0194@1,COG0194@2 NA|NA|NA F Essential for recycling GMP and indirectly, cGMP HLLCKODE_01482 1046629.Ssal_00637 3.6e-46 190.7 Bacteria rpoZ GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria COG1758@1,COG1758@2 NA|NA|NA K DNA-directed 5'-3' RNA polymerase activity HLLCKODE_01483 1046629.Ssal_00638 0.0 1550.0 Bacilli priA GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 ko:K04066 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 1TNYB@1239,4H9WW@91061,COG1198@1,COG1198@2 NA|NA|NA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA HLLCKODE_01484 435842.HMPREF0848_01065 5.2e-170 603.6 Bacilli fmt GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 R03940 RC00026,RC00165 ko00000,ko00001,ko01000 iSB619.SA_RS06010 Bacteria 1TQ32@1239,4HART@91061,COG0223@1,COG0223@2 NA|NA|NA J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus HLLCKODE_01485 904306.HMPREF9192_0956 8.9e-240 835.9 Bacilli sun GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176 ko:K03500 ko00000,ko01000,ko03009 Bacteria 1TP3N@1239,4HBQ6@91061,COG0144@1,COG0144@2,COG0781@1,COG0781@2 NA|NA|NA J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA HLLCKODE_01486 1046629.Ssal_00642 1.5e-135 488.8 Bacilli stp 3.1.3.16 ko:K20074 ko00000,ko01000,ko01009 Bacteria 1V6K5@1239,4HCDR@91061,COG0631@1,COG0631@2 NA|NA|NA T phosphatase HLLCKODE_01487 435842.HMPREF0848_01062 4.4e-293 1013.4 Bacilli prkC GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701 2.7.11.1 ko:K12132 ko00000,ko01000,ko01001 Bacteria 1TP3F@1239,4H9KD@91061,COG0515@1,COG0515@2,COG2815@1,COG2815@2 NA|NA|NA KLT serine threonine protein kinase HLLCKODE_01488 1046629.Ssal_00644 2.1e-100 372.1 Bacilli kcsA GO:0003674,GO:0005215,GO:0005216,GO:0005244,GO:0005249,GO:0005261,GO:0005267,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0022803,GO:0022832,GO:0022836,GO:0022838,GO:0022839,GO:0022843,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662 ko:K10716 ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 Bacteria 1V285@1239,4I17E@91061,COG1226@1,COG1226@2 NA|NA|NA P Ion transport protein HLLCKODE_01489 435842.HMPREF0848_01061 1.9e-116 425.2 Bacilli yvqF ko:K11622 ko02020,map02020 ko00000,ko00001 Bacteria 1V3D0@1239,4HDIA@91061,COG4758@1,COG4758@2 NA|NA|NA S Membrane HLLCKODE_01490 435842.HMPREF0848_01060 9.7e-170 602.8 Bacilli vraS 2.7.13.3 ko:K07673,ko:K07681,ko:K11617 ko02020,map02020 M00471,M00480,M00481,M00754 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1TPDG@1239,4HC7E@91061,COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase HLLCKODE_01491 322159.STER_1387 3.1e-113 414.5 Bacilli vraR ko:K07694,ko:K11618 ko02020,map02020 M00480,M00481,M00754 ko00000,ko00001,ko00002,ko02022 Bacteria 1TQ1U@1239,4HA4B@91061,COG2197@1,COG2197@2 NA|NA|NA K Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain HLLCKODE_01494 1046629.Ssal_00648 2.2e-93 348.2 Bacilli rimM GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 ko:K02860 ko00000,ko03009 Bacteria 1V6HD@1239,4HH3H@91061,COG0806@1,COG0806@2 NA|NA|NA J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes HLLCKODE_01495 1046629.Ssal_00649 1.9e-135 488.4 Bacilli trmD GO:0000287,GO:0001510,GO:0002939,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050518,GO:0052906,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228,4.6.1.12 ko:K00554,ko:K01770 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R00597,R05637 RC00002,RC00003,RC00334,RC01440 ko00000,ko00001,ko00002,ko01000,ko03016 Bacteria 1TPBV@1239,4HBFV@91061,COG0336@1,COG0336@2 NA|NA|NA J Belongs to the RNA methyltransferase TrmD family HLLCKODE_01496 1046629.Ssal_00650 3.1e-184 651.0 Bacilli trxB1 1.18.1.2,1.19.1.1 ko:K21567 ko00000,ko01000 Bacteria 1TRPN@1239,4H9V7@91061,COG0492@1,COG0492@2 NA|NA|NA C Ferredoxin--NADP reductase HLLCKODE_01497 1046629.Ssal_00651 0.0 1406.3 Bacilli ftsK GO:0000003,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0019954,GO:0030436,GO:0031323,GO:0031326,GO:0032502,GO:0043934,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 ko:K03466 ko00000,ko03036 3.A.12 Bacteria 1TPJR@1239,4H9WA@91061,COG1674@1,COG1674@2 NA|NA|NA D Belongs to the FtsK SpoIIIE SftA family HLLCKODE_01498 1046629.Ssal_00653 0.0 1431.8 Bacilli pulA 3.2.1.41 ko:K01200 ko00500,ko01100,ko01110,map00500,map01100,map01110 R02111 ko00000,ko00001,ko01000 CBM48,GH13 Bacteria 1TP3M@1239,4HBP5@91061,COG1523@1,COG1523@2 NA|NA|NA G belongs to the glycosyl hydrolase 13 family HLLCKODE_01499 1046629.Ssal_00654 0.0 1336.2 Bacilli glgB GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033554,GO:0033692,GO:0034637,GO:0034645,GO:0040007,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0071944,GO:1901576 2.4.1.18,3.2.1.141,3.2.1.20 ko:K00700,ko:K01187,ko:K01236,ko:K17734 ko00052,ko00500,ko01100,ko01110,map00052,map00500,map01100,map01110 M00565 R00028,R00801,R00802,R02110,R06087,R06088,R09995,R11256 RC00028,RC00049,RC00077 ko00000,ko00001,ko00002,ko01000,ko01002,ko04147 CBM48,GH13,GH31 iAPECO1_1312.APECO1_3025,iECNA114_1301.ECNA114_3542,iECOK1_1307.ECOK1_3857,iECS88_1305.ECS88_3830,iECSF_1327.ECSF_3253,iJN678.glgB,iLF82_1304.LF82_0837,iNRG857_1313.NRG857_17030,iUTI89_1310.UTI89_C3941 Bacteria 1TP4M@1239,4HAPM@91061,COG0296@1,COG0296@2 NA|NA|NA G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position HLLCKODE_01500 904306.HMPREF9192_0971 5.8e-187 660.2 Bacilli glgC 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 1TNZW@1239,4HAZX@91061,COG0448@1,COG0448@2 NA|NA|NA H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans HLLCKODE_01501 1046629.Ssal_00656 8.9e-180 636.3 Bacilli glgD 2.4.1.21,2.7.7.27 ko:K00703,ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948,R02421 RC00002,RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 GT5 Bacteria 1TPZ3@1239,4H9UQ@91061,COG0448@1,COG0448@2 NA|NA|NA G glucose-1-phosphate adenylyltransferase HLLCKODE_01502 1046629.Ssal_00657 7e-283 979.2 Bacilli glgA GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 GT5 Bacteria 1TQ4M@1239,4HAVA@91061,COG0297@1,COG0297@2 NA|NA|NA G Synthesizes alpha-1,4-glucan chains using ADP-glucose HLLCKODE_01503 1046629.Ssal_00658 0.0 1593.6 Bacilli glgP GO:0000272,GO:0003674,GO:0003824,GO:0004645,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0005977,GO:0005980,GO:0006073,GO:0006091,GO:0006112,GO:0008144,GO:0008150,GO:0008152,GO:0008184,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901575 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 R02111 ko00000,ko00001,ko01000 GT35 iYO844.BSU30940 Bacteria 1TQAJ@1239,4H9XI@91061,COG0058@1,COG0058@2 NA|NA|NA G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties HLLCKODE_01504 1046629.Ssal_00659 1.8e-101 375.2 Bacilli 2.3.1.128 ko:K03789 ko00000,ko01000,ko03009 Bacteria 1VEW7@1239,4HPE4@91061,COG0454@1,COG0456@2 NA|NA|NA K Acetyltransferase GNAT Family HLLCKODE_01505 1046629.Ssal_00660 5.4e-281 973.0 Bacilli Bacteria 1VBKU@1239,2DI63@1,32UAI@2,4HUJH@91061 NA|NA|NA S Protein of unknown function (DUF3114) HLLCKODE_01507 999425.HMPREF9186_00510 0.0 1491.5 Bacilli gshF 6.3.2.2,6.3.2.29,6.3.2.30,6.3.2.4 ko:K01919,ko:K01921,ko:K03802,ko:K16786,ko:K16787 ko00270,ko00473,ko00480,ko00550,ko01100,ko01502,ko02010,map00270,map00473,map00480,map00550,map01100,map01502,map02010 M00118,M00582 R00894,R01150,R10993 RC00064,RC00090,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 Bacteria 1TPGX@1239,4HAMJ@91061,COG1181@1,COG1181@2,COG2918@1,COG2918@2 NA|NA|NA H Belongs to the glutamate--cysteine ligase type 1 family HLLCKODE_01508 904306.HMPREF9192_0998 1e-296 1025.4 Bacilli ko:K06147,ko:K06148 ko00000,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 1TP0B@1239,4H9SC@91061,COG1132@1,COG1132@2 NA|NA|NA V abc transporter atp-binding protein HLLCKODE_01509 904306.HMPREF9192_0999 0.0 1169.8 Bacilli ko:K06147 ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 1TP0B@1239,4HA3S@91061,COG1132@1,COG1132@2 NA|NA|NA V abc transporter atp-binding protein HLLCKODE_01510 1046629.Ssal_00666 1.2e-184 652.9 Bacilli XK27_10075 ko:K06158 ko00000,ko03012 Bacteria 1TU6J@1239,4HDY2@91061,COG0488@1,COG0488@2 NA|NA|NA S abc transporter atp-binding protein HLLCKODE_01511 388919.SSA_1653 3.7e-10 72.8 Streptococcus sanguinis Bacteria 1UAAZ@1239,1WS2E@1305,29RPD@1,30CSR@2,4IKNZ@91061 NA|NA|NA HLLCKODE_01513 1114965.Spaf_1943 1.2e-81 309.3 Bacteria 3.4.21.110 ko:K08652 ko00000,ko01000,ko01002,ko03110 Bacteria COG3087@1,COG3087@2,COG4932@1,COG4932@2 NA|NA|NA D Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides HLLCKODE_01514 435842.HMPREF0848_01038 0.0 4088.1 Bacteria Bacteria COG4932@1,COG4932@2 NA|NA|NA M domain protein HLLCKODE_01515 1046629.Ssal_00726 1.2e-134 486.1 Bacteria Bacteria COG5263@1,COG5263@2 NA|NA|NA S dextransucrase activity HLLCKODE_01516 435842.HMPREF0848_00996 0.0 1556.2 Firmicutes Bacteria 1V0PX@1239,COG5263@1,COG5263@2 NA|NA|NA M Putative cell wall binding repeat HLLCKODE_01519 435842.HMPREF0848_00996 4.8e-226 791.2 Firmicutes Bacteria 1V0PX@1239,COG5263@1,COG5263@2 NA|NA|NA M Putative cell wall binding repeat HLLCKODE_01522 1046629.Ssal_00208 1.2e-222 778.9 Firmicutes Bacteria 1TQ93@1239,COG3464@1,COG3464@2 NA|NA|NA L Transposase HLLCKODE_01523 435842.HMPREF0848_01445 1e-148 532.7 Bacilli Bacteria 1TPSP@1239,4IPIG@91061,COG3547@1,COG3547@2 NA|NA|NA L COG3547 Transposase and inactivated derivatives HLLCKODE_01525 1046629.Ssal_00210 1.6e-49 201.8 Bacteria bta 1.8.1.8 ko:K03671,ko:K03672 ko04621,ko05418,map04621,map05418 ko00000,ko00001,ko01000,ko03110 Bacteria COG0526@1,COG0526@2 NA|NA|NA CO cell redox homeostasis HLLCKODE_01526 435842.HMPREF0848_01462 7e-58 229.9 Bacilli ko:K07107 ko00000,ko01000 Bacteria 1VAGM@1239,4HIVC@91061,COG0824@1,COG0824@2 NA|NA|NA L thioesterase HLLCKODE_01527 1046629.Ssal_00214 5.6e-141 506.9 Bacilli Bacteria 1TQSZ@1239,4HCXD@91061,COG2110@1,COG2110@2 NA|NA|NA S Macro domain protein HLLCKODE_01528 904306.HMPREF9192_0562 2.4e-50 204.5 Bacilli trxA ko:K03671 ko04621,ko05418,map04621,map05418 ko00000,ko00001,ko03110 Bacteria 1VA3Y@1239,4HKKX@91061,COG3118@1,COG3118@2 NA|NA|NA O Belongs to the thioredoxin family HLLCKODE_01529 1046629.Ssal_00216 5.4e-69 266.9 Bacilli yccU GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K06929 ko00000 Bacteria 1V7C7@1239,4HIZT@91061,COG1832@1,COG1832@2 NA|NA|NA S CoA-binding protein HLLCKODE_01530 1046629.Ssal_00217 5.2e-142 510.4 Bacilli tatD GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575 ko:K03424 ko00000,ko01000 Bacteria 1TNY1@1239,4HA74@91061,COG0084@1,COG0084@2 NA|NA|NA L Hydrolase, tatd HLLCKODE_01531 1046629.Ssal_00218 3.2e-98 364.4 Bacilli rnmV GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043822,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360 3.1.26.8 ko:K05985,ko:K07476 ko00000,ko01000 Bacteria 1V3K3@1239,4HH5Y@91061,COG1658@1,COG1658@2 NA|NA|NA J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step HLLCKODE_01532 1046629.Ssal_00219 4.2e-153 547.4 Bacilli ksgA GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 ko:K02528 R10716 RC00003,RC03257 ko00000,ko01000,ko03009 Bacteria 1TP9W@1239,4HA4R@91061,COG0030@1,COG0030@2 NA|NA|NA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits HLLCKODE_01534 1046629.Ssal_00220 7.8e-160 569.7 Bacilli rsgA 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 Bacteria 1TPSQ@1239,4HA9W@91061,COG1162@1,COG1162@2 NA|NA|NA G One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit HLLCKODE_01535 904306.HMPREF9192_0569 7.8e-120 436.4 Bacilli rpe 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQK8@1239,4H9RW@91061,COG0036@1,COG0036@2 NA|NA|NA G Belongs to the ribulose-phosphate 3-epimerase family HLLCKODE_01536 1046629.Ssal_00222 2e-112 411.8 Bacilli thiN 2.7.6.2 ko:K00949 ko00730,ko01100,map00730,map01100 R00619 RC00002,RC00017 ko00000,ko00001,ko01000 Bacteria 1VA0W@1239,4HHS1@91061,COG1564@1,COG1564@2 NA|NA|NA H thiamine pyrophosphokinase HLLCKODE_01537 1046629.Ssal_00223 1.8e-168 599.0 Bacilli rmuC ko:K09760 ko00000 Bacteria 1TPWI@1239,4HE2N@91061,COG1322@1,COG1322@2 NA|NA|NA S RmuC domain protein HLLCKODE_01538 1046629.Ssal_00224 1.2e-177 629.0 Bacilli cbf ko:K03698 ko00000,ko01000,ko03019 Bacteria 1TPIU@1239,4HB1M@91061,COG3481@1,COG3481@2 NA|NA|NA S 3'-5' exoribonuclease yhaM HLLCKODE_01539 904306.HMPREF9192_0573 6.9e-142 510.0 Bacilli purR 2.4.2.7 ko:K00759,ko:K09685 ko00230,ko01100,map00230,map01100 R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko03000,ko04147 Bacteria 1TPN9@1239,4HB8I@91061,COG0503@1,COG0503@2 NA|NA|NA F operon repressor HLLCKODE_01540 1046629.Ssal_00226 2.3e-69 268.1 Bacilli rpsL GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02950 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V1FJ@1239,4HFMZ@91061,COG0048@1,COG0048@2 NA|NA|NA J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit HLLCKODE_01541 1046629.Ssal_00227 3.9e-81 307.4 Bacilli rpsG GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016020,GO:0016043,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02992 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V1GG@1239,4H9PA@91061,COG0049@1,COG0049@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA HLLCKODE_01542 1046629.Ssal_00229 0.0 1363.2 Bacilli fusA GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0030312,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02355 ko00000,ko03012,ko03029 Bacteria 1TPF9@1239,4HAB8@91061,COG0480@1,COG0480@2 NA|NA|NA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome HLLCKODE_01543 1005705.HMPREF9967_0458 7.1e-181 639.8 Streptococcus infantis gap GO:0000166,GO:0002020,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009986,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0019362,GO:0019637,GO:0019674,GO:0019899,GO:0022610,GO:0034641,GO:0036094,GO:0043891,GO:0044237,GO:0044238,GO:0044281,GO:0044403,GO:0044406,GO:0044419,GO:0044424,GO:0044464,GO:0044650,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051287,GO:0051704,GO:0055086,GO:0055114,GO:0071704,GO:0072524,GO:0097159,GO:0140030,GO:0140032,GO:1901265,GO:1901360,GO:1901363,GO:1901564 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 Bacteria 1TNYU@1239,43FFT@68892,4H9NS@91061,COG0057@1,COG0057@2 NA|NA|NA C Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain HLLCKODE_01544 1046629.Ssal_00231 3.4e-113 414.5 Firmicutes Bacteria 1V2YR@1239,28KD0@1,2Z9ZS@2 NA|NA|NA HLLCKODE_01545 1046629.Ssal_00232 5.8e-222 776.5 Bacilli pgk GO:0001871,GO:0002020,GO:0003674,GO:0003824,GO:0004618,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009893,GO:0009986,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019222,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030162,GO:0030193,GO:0030195,GO:0030246,GO:0030247,GO:0030312,GO:0031323,GO:0031325,GO:0032101,GO:0032102,GO:0032268,GO:0032270,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043532,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0045862,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048518,GO:0048519,GO:0048522,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050818,GO:0050819,GO:0050878,GO:0051171,GO:0051173,GO:0051186,GO:0051188,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051917,GO:0051919,GO:0055086,GO:0060255,GO:0061041,GO:0061045,GO:0065007,GO:0065008,GO:0070613,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0080134,GO:0090407,GO:1900046,GO:1900047,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903034,GO:1903035,GO:1903317,GO:1903319,GO:2001065 2.7.2.3,5.3.1.1 ko:K00927,ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01015,R01512 RC00002,RC00043,RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 iSB619.SA_RS04145 Bacteria 1TP3H@1239,4H9R3@91061,COG0126@1,COG0126@2 NA|NA|NA F Belongs to the phosphoglycerate kinase family HLLCKODE_01546 1046629.Ssal_00233 3.7e-85 320.9 Bacilli Bacteria 1VAJG@1239,4HKDZ@91061,COG4129@1,COG4129@2 NA|NA|NA S Fusaric acid resistance protein-like HLLCKODE_01547 435842.HMPREF0848_01442 8.5e-63 246.1 Bacilli glnR GO:0003674,GO:0005488,GO:0005515,GO:0006082,GO:0006355,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016053,GO:0019219,GO:0019222,GO:0019752,GO:0031323,GO:0031326,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1903506,GO:2000112,GO:2001141 ko:K03713,ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 ko00000,ko00001,ko00002,ko02000,ko03000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 1V6JE@1239,4HKM6@91061,COG0789@1,COG0789@2 NA|NA|NA K Transcriptional regulator HLLCKODE_01548 1046629.Ssal_00235 5.2e-264 916.4 Bacilli glnA 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 Bacteria 1TNZA@1239,4HACE@91061,COG0174@1,COG0174@2 NA|NA|NA E glutamine synthetase HLLCKODE_01549 435842.HMPREF0848_01440 5.6e-115 420.2 Bacilli pscB Bacteria 1V8WM@1239,4HIMT@91061,COG3942@1,COG3942@2 NA|NA|NA M CHAP domain protein HLLCKODE_01550 435842.HMPREF0848_01439 0.0 1111.7 Bacilli rnjA GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004527,GO:0004532,GO:0004534,GO:0004540,GO:0005488,GO:0005515,GO:0006139,GO:0006364,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008409,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042802,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0090503,GO:0140098,GO:1901360 ko:K12574 ko03018,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 1TQ9G@1239,4HAAP@91061,COG0595@1,COG0595@2 NA|NA|NA S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay HLLCKODE_01551 1046629.Ssal_00239 1.5e-33 148.3 Bacilli ykzG Bacteria 1VEI7@1239,4HNSK@91061,COG5503@1,COG5503@2 NA|NA|NA S Belongs to the UPF0356 family HLLCKODE_01552 435842.HMPREF0848_01437 1.6e-115 422.2 Bacilli yeaZ GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 ko:K01409,ko:K14742 R10648 RC00070,RC00416 ko00000,ko01000,ko03016 Bacteria 1V4YX@1239,4HHD7@91061,COG1214@1,COG1214@2 NA|NA|NA O COG1214, inactive homolog of metal-dependent proteases HLLCKODE_01553 264199.stu1771 2e-71 275.0 Bacilli rimI 2.3.1.128 ko:K03789 ko00000,ko01000,ko03009 Bacteria 1V6KU@1239,4HP50@91061,COG0454@1,COG0456@2 NA|NA|NA K This enzyme acetylates the N-terminal alanine of ribosomal protein S18 HLLCKODE_01554 1046629.Ssal_00242 3.3e-186 657.5 Bacilli tsaD GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 ko:K01409,ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 R10648 RC00070,RC00416 ko00000,ko00001,ko00002,ko01000,ko02044,ko03016 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 Bacteria 1TQDR@1239,4HANB@91061,COG0533@1,COG0533@2 NA|NA|NA O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction HLLCKODE_01555 435842.HMPREF0848_01434 3e-114 417.9 Bacilli azlC Bacteria 1V64T@1239,4HH44@91061,COG1296@1,COG1296@2 NA|NA|NA E AzlC protein HLLCKODE_01556 435842.HMPREF0848_01433 3.7e-46 190.7 Bacilli azlD Bacteria 1VH9Q@1239,4HRBI@91061,COG4392@1,COG4392@2 NA|NA|NA S branched-chain amino acid HLLCKODE_01557 1046629.Ssal_00246 0.0 1563.1 Bacilli recD2 3.1.11.5 ko:K03581 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 1TPZH@1239,4HATQ@91061,COG0507@1,COG0507@2 NA|NA|NA L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity HLLCKODE_01558 1046629.Ssal_00248 1.1e-113 416.0 Bacilli lepB 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 ko00000,ko00001,ko01000,ko01002 Bacteria 1V7H9@1239,4HMGQ@91061,COG0681@1,COG0681@2 NA|NA|NA U Belongs to the peptidase S26 family HLLCKODE_01559 1046629.Ssal_00249 5.8e-155 553.5 Bacilli rnhC GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03470,ko:K03471 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Bacteria 1TQBE@1239,4H9QR@91061,COG1039@1,COG1039@2 NA|NA|NA L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids HLLCKODE_01560 1302863.I872_01550 2.7e-14 84.3 Bacilli zapA GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0000921,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032185,GO:0032505,GO:0032506,GO:0034622,GO:0042802,GO:0043093,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0051301,GO:0061640,GO:0065003,GO:0070925,GO:0071840,GO:0090529,GO:1902410,GO:1903047 ko:K09888 ko00000,ko03036 Bacteria 1VFZS@1239,4HP4T@91061,COG3027@1,COG3027@2 NA|NA|NA D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division HLLCKODE_01561 1046629.Ssal_00251 1.4e-90 339.0 Bacteria cvpA GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009403,GO:0009404,GO:0009987,GO:0016020,GO:0019748,GO:0044237,GO:0044249,GO:0044464,GO:0044550,GO:0071944 ko:K03558 ko00000 Bacteria COG1286@1,COG1286@2 NA|NA|NA S toxin biosynthetic process HLLCKODE_01562 435842.HMPREF0848_01427 0.0 1481.5 Bacilli mutS2 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 ko:K07456 ko03430,map03430 ko00000,ko00001,ko03400 Bacteria 1TP5W@1239,4H9NZ@91061,COG1193@1,COG1193@2 NA|NA|NA L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity HLLCKODE_01563 435842.HMPREF0848_01419 0.0 1685.2 Bacilli polA GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 Bacteria 1TPKJ@1239,4H9S7@91061,COG0258@1,COG0258@2,COG0749@1,COG0749@2 NA|NA|NA L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity HLLCKODE_01565 397288.C806_03616 1.7e-37 162.2 unclassified Lachnospiraceae Bacteria 1VB8V@1239,24KMP@186801,27ME7@186928,2DZDF@1,32V7U@2 NA|NA|NA HLLCKODE_01566 585202.SMSK321_0738 4.5e-10 70.5 Streptococcus mitis Bacteria 1U4B0@1239,2DKAS@1,2TP5R@28037,30920@2,4IE2N@91061 NA|NA|NA HLLCKODE_01568 1046629.Ssal_00266 2.9e-218 764.2 Bacilli mutY ko:K03575 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 1TPUT@1239,4H9UM@91061,COG1194@1,COG1194@2 NA|NA|NA L A G-specific adenine glycosylase HLLCKODE_01569 1214166.ALLG01000021_gene137 1.1e-42 180.6 Streptococcus suis XK27_05745 Bacteria 1U8WY@1239,1WSBS@1307,2BJFN@1,32DS8@2,4IIVI@91061 NA|NA|NA HLLCKODE_01570 904306.HMPREF9192_0608 3e-47 194.1 Bacilli rpsF GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904 ko:K02990 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011,ko03029 Bacteria 1VA18@1239,4HKHD@91061,COG0360@1,COG0360@2 NA|NA|NA J Binds together with S18 to 16S ribosomal RNA HLLCKODE_01571 264199.stu1753 6.7e-84 316.6 Bacilli ssb ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 ko00000,ko00001,ko03029,ko03032,ko03400 Bacteria 1V3WT@1239,4HH8I@91061,COG0629@1,COG0629@2 NA|NA|NA L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism HLLCKODE_01572 1046629.Ssal_00271 1.7e-35 154.8 Bacilli rpsR GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02963,ko:K03111,ko:K15125 ko03010,ko03030,ko03430,ko03440,ko05133,map03010,map03030,map03430,map03440,map05133 M00178 br01610,ko00000,ko00001,ko00002,ko00536,ko03011,ko03029,ko03032,ko03400 Bacteria 1V9XS@1239,4HKCC@91061,COG0238@1,COG0238@2 NA|NA|NA J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit HLLCKODE_01574 1046629.Ssal_00273 2.6e-123 448.0 Bacilli XK27_01040 Bacteria 1VF5N@1239,4HMVT@91061,COG4858@1,COG4858@2 NA|NA|NA S Protein of unknown function (DUF1129) HLLCKODE_01575 435842.HMPREF0848_01411 6.5e-168 596.7 Bacilli corA ko:K03284 ko00000,ko02000 1.A.35.1,1.A.35.3 Bacteria 1TPI8@1239,4HE7S@91061,COG0598@1,COG0598@2 NA|NA|NA P COG0598 Mg2 and Co2 transporters HLLCKODE_01576 1046629.Ssal_00276 0.0 1870.5 Bacilli uvrA ko:K03701 ko03420,map03420 ko00000,ko00001,ko03400 Bacteria 1TPIJ@1239,4HAW9@91061,COG0178@1,COG0178@2 NA|NA|NA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate HLLCKODE_01580 1123311.KB904456_gene755 6.1e-32 144.8 Bacilli blpT Bacteria 1W6SH@1239,2DWQH@1,341F6@2,4HX74@91061 NA|NA|NA HLLCKODE_01582 1046629.Ssal_00280 1.2e-186 659.1 Bacilli pepP GO:0003674,GO:0003824,GO:0004177,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.11.9,3.4.13.9 ko:K01262,ko:K01271,ko:K08326 ko00000,ko01000,ko01002 Bacteria 1TQ44@1239,4HAT7@91061,COG0006@1,COG0006@2 NA|NA|NA E Belongs to the peptidase M24B family HLLCKODE_01583 1046629.Ssal_00281 1.3e-84 318.9 Bacilli comEB 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 Bacteria 1V8V0@1239,4IQZA@91061,COG2131@1,COG2131@2 NA|NA|NA F ComE operon protein 2 HLLCKODE_01584 904306.HMPREF9192_0624 7.1e-98 363.2 Bacilli efp GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02356 ko00000,ko03012 Bacteria 1TR8P@1239,4H9YX@91061,COG0231@1,COG0231@2 NA|NA|NA J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase HLLCKODE_01585 1046629.Ssal_00283 1.7e-61 241.9 Bacilli yqhY ko:K10947 ko00000,ko03000 Bacteria 1V4IC@1239,4HJ7T@91061,COG1302@1,COG1302@2 NA|NA|NA S protein conserved in bacteria HLLCKODE_01586 1046629.Ssal_00284 8.1e-73 279.6 Bacilli nusB ko:K03625 ko00000,ko03009,ko03021 Bacteria 1VA9B@1239,4HKMU@91061,COG0781@1,COG0781@2 NA|NA|NA K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons HLLCKODE_01587 435842.HMPREF0848_01398 7.5e-180 636.3 Firmicutes scrR ko:K02529,ko:K03484 ko00000,ko03000 Bacteria 1TQ7K@1239,COG1609@1,COG1609@2 NA|NA|NA K Transcriptional regulator HLLCKODE_01588 1046629.Ssal_00286 4.7e-287 993.0 Bacilli scrB 3.2.1.26,3.2.1.80 ko:K01193,ko:K03332 ko00051,ko00052,ko00500,ko01100,map00051,map00052,map00500,map01100 R00801,R00802,R00879,R02410,R03635,R03921,R06088 RC00028,RC00077 ko00000,ko00001,ko01000 GH32 Bacteria 1TPAE@1239,4H9Y7@91061,COG1621@1,COG1621@2 NA|NA|NA G invertase HLLCKODE_01589 1046629.Ssal_00287 0.0 1201.8 Bacilli scrA 2.7.1.201,2.7.1.208,2.7.1.211 ko:K02755,ko:K02756,ko:K02757,ko:K02777,ko:K02808,ko:K02809,ko:K02810,ko:K02817,ko:K02818,ko:K02819,ko:K20107,ko:K20108 ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111 M00265,M00266,M00268,M00269,M00270,M00271,M00272,M00303,M00806 R00811,R02738,R02780,R04111,R04394,R05132,R08559 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.1,4.A.1.1.11,4.A.1.1.12,4.A.1.2.1,4.A.1.2.10,4.A.1.2.11,4.A.1.2.12,4.A.1.2.13,4.A.1.2.2,4.A.1.2.4,4.A.1.2.5,4.A.1.2.6,4.A.1.2.8,4.A.1.2.9 Bacteria 1TP5X@1239,4HA0I@91061,COG1263@1,COG1263@2,COG1264@1,COG1264@2,COG2190@1,COG2190@2 NA|NA|NA G pts system HLLCKODE_01590 904306.HMPREF9192_0630 2e-171 608.2 Bacilli scrK 2.7.1.2,2.7.1.4 ko:K00845,ko:K00847 ko00010,ko00051,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R00760,R00867,R01600,R01786,R03920 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQU4@1239,4HA1C@91061,COG1940@1,COG1940@2 NA|NA|NA GK Fructokinase HLLCKODE_01591 1046629.Ssal_00290 1.9e-188 664.8 Bacilli manA 5.3.1.8 ko:K01809 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01819 RC00376 ko00000,ko00001,ko00002,ko01000 Bacteria 1VRGI@1239,4HBFW@91061,COG1482@1,COG1482@2 NA|NA|NA G mannose-6-phosphate isomerase HLLCKODE_01593 1046629.Ssal_00292 0.0 1656.3 Bacilli secA GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 Bacteria 1TPEY@1239,4HA22@91061,COG0653@1,COG0653@2 NA|NA|NA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane HLLCKODE_01594 1046629.Ssal_00294 1.1e-197 695.7 Firmicutes aroF 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS07240 Bacteria 1TQI4@1239,COG0722@1,COG0722@2 NA|NA|NA E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) HLLCKODE_01595 1046629.Ssal_00295 9.4e-197 692.6 Firmicutes aroF 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS07240 Bacteria 1TQI4@1239,COG0722@1,COG0722@2 NA|NA|NA E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) HLLCKODE_01596 1046629.Ssal_00296 3.4e-61 240.7 Bacilli acpS 2.7.6.3,2.7.8.7,5.1.1.1 ko:K00950,ko:K00997,ko:K01775 ko00473,ko00770,ko00790,ko01100,ko01502,map00473,map00770,map00790,map01100,map01502 M00126,M00841 R00401,R01625,R03503 RC00002,RC00017,RC00285 ko00000,ko00001,ko00002,ko01000,ko01011 iYO844.BSU04620 Bacteria 1VA0T@1239,4HKBI@91061,COG0736@1,COG0736@2 NA|NA|NA I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein HLLCKODE_01597 1046629.Ssal_00297 3.2e-203 714.1 Bacilli alr 5.1.1.1,5.1.1.5 ko:K01775,ko:K20707 ko00473,ko01100,ko01502,map00473,map01100,map01502 R00401 RC00285 ko00000,ko00001,ko01000,ko01011 Bacteria 1TNYY@1239,4HA95@91061,COG0787@1,COG0787@2 NA|NA|NA E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids HLLCKODE_01598 435842.HMPREF0848_01388 0.0 1297.0 Bacilli recG GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 ko:K03655 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 1TQ6I@1239,4HAWN@91061,COG1200@1,COG1200@2 NA|NA|NA L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) HLLCKODE_01602 1046629.Ssal_00306 2.9e-31 140.6 Firmicutes yozG ko:K07727 ko00000,ko03000 Bacteria 1VESP@1239,COG3655@1,COG3655@2 NA|NA|NA K Transcriptional regulator HLLCKODE_01604 1046629.Ssal_00308 3e-170 604.4 Bacilli ansA 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 R00485 RC00010,RC02798 ko00000,ko00001,ko01000 Bacteria 1TPP9@1239,4H9YJ@91061,COG0252@1,COG0252@2 NA|NA|NA EJ COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D HLLCKODE_01605 904306.HMPREF9192_0643 4e-259 900.2 Bacilli XK27_03190 ko:K16785 ko02010,map02010 M00582 ko00000,ko00001,ko00002,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 Bacteria 1TSZZ@1239,4HB54@91061,COG0561@1,COG0561@2,COG4696@1,COG4696@2 NA|NA|NA S hydrolases of the HAD superfamily HLLCKODE_01606 1046629.Ssal_00310 2.6e-97 362.5 Bacilli yebC ko:K16637 ko00000,ko02042 Bacteria 1VK5M@1239,4HS44@91061,COG3064@1,COG3064@2 NA|NA|NA M Membrane HLLCKODE_01607 1046629.Ssal_00311 0.0 1076.6 Bacteria Bacteria COG4640@1,COG4640@2 NA|NA|NA KT response to antibiotic HLLCKODE_01608 1046629.Ssal_00312 7.5e-74 283.1 Bacilli XK27_02470 Bacteria 1VBF7@1239,4HHGZ@91061,COG3279@1,COG3279@2 NA|NA|NA K LytTr DNA-binding domain protein HLLCKODE_01609 1046629.Ssal_00313 1.2e-99 369.4 Bacilli liaI ko:K11619 ko02020,map02020 M00754 ko00000,ko00001,ko00002 Bacteria 1VGSF@1239,4IRBC@91061,COG4758@1,COG4758@2 NA|NA|NA S membrane HLLCKODE_01610 1046629.Ssal_00314 7e-298 1029.2 Firmicutes ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 Bacteria 1TSUC@1239,COG0443@1,COG0443@2 NA|NA|NA O MreB/Mbl protein HLLCKODE_01612 1046629.Ssal_00316 5.8e-146 523.5 Firmicutes GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0008150,GO:0015399,GO:0015405,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0030312,GO:0031224,GO:0042623,GO:0042626,GO:0043492,GO:0044424,GO:0044425,GO:0044444,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 ko:K01990,ko:K21397 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1V0ED@1239,COG1131@1,COG1131@2 NA|NA|NA V Psort location CytoplasmicMembrane, score HLLCKODE_01615 365659.smi_1723 2.6e-13 84.0 Streptococcus mitis Bacteria 1U4TK@1239,2DKFM@1,2TQA8@28037,309CC@2,4IEJ2@91061 NA|NA|NA HLLCKODE_01616 1046629.Ssal_00320 3.5e-228 797.3 Bacteria dcuS GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016020,GO:0016021,GO:0016043,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0023014,GO:0023052,GO:0031224,GO:0031226,GO:0031323,GO:0031326,GO:0035556,GO:0036211,GO:0042802,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051259,GO:0051260,GO:0051716,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0140096,GO:1901564,GO:1903506,GO:2000112,GO:2001141 2.7.13.3 ko:K02476,ko:K07701,ko:K07706,ko:K11614 ko02020,ko02024,map02020,map02024 M00488,M00490,M00495 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria COG3290@1,COG3290@2 NA|NA|NA T protein histidine kinase activity HLLCKODE_01617 1046629.Ssal_00321 4.9e-233 813.5 Bacteria 2.7.13.3 ko:K07706 ko02020,ko02024,map02020,map02024 M00495 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria COG3290@1,COG3290@2 NA|NA|NA T protein histidine kinase activity HLLCKODE_01618 1046629.Ssal_00322 0.0 2108.2 Bacilli rexB GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0004518,GO:0004519,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.21.3,3.6.4.12 ko:K01153,ko:K16899 ko00000,ko01000,ko02048,ko03400 Bacteria 1TQJW@1239,4HAY6@91061,COG3857@1,COG3857@2 NA|NA|NA L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination HLLCKODE_01619 1046629.Ssal_00325 0.0 2329.3 Bacilli addA 3.6.4.12 ko:K16898 ko00000,ko01000,ko03400 Bacteria 1TQ35@1239,4HA64@91061,COG1074@1,COG1074@2 NA|NA|NA L ATP-dependent helicase nuclease subunit A HLLCKODE_01620 1046629.Ssal_00327 6.3e-118 430.3 Bacilli ko:K07150 ko00000 Bacteria 1TQWV@1239,4HEYY@91061,COG1811@1,COG1811@2 NA|NA|NA S Protein of unknown function (DUF554) HLLCKODE_01621 1046629.Ssal_00328 8.1e-134 483.0 Bacilli ecsA_2 ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TQIH@1239,4HCEU@91061,COG1131@1,COG1131@2 NA|NA|NA V abc transporter atp-binding protein HLLCKODE_01622 1046629.Ssal_00329 9.8e-286 988.8 Bacilli XK27_00765 ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TSZA@1239,28MBB@1,2ZAPV@2,4HDKH@91061 NA|NA|NA HLLCKODE_01623 904306.HMPREF9192_0659 1.1e-139 502.7 Bacilli proB GO:0003674,GO:0003824,GO:0004349,GO:0004350,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016491,GO:0016620,GO:0016740,GO:0016772,GO:0016774,GO:0016903,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPG6@1239,4HA9B@91061,COG0263@1,COG0263@2 NA|NA|NA E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate HLLCKODE_01624 904306.HMPREF9192_0660 6e-222 776.5 Bacilli proA GO:0003674,GO:0003824,GO:0004350,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0055114,GO:0055129,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 iB21_1397.B21_00243,iECBD_1354.ECBD_3376,iECB_1328.ECB_00240,iECD_1391.ECD_00240,iLJ478.TM0293,iYL1228.KPN_00280,iYO844.BSU13130 Bacteria 1TQ9V@1239,4HB7B@91061,COG0014@1,COG0014@2 NA|NA|NA E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate HLLCKODE_01625 435842.HMPREF0848_01359 9.2e-60 236.1 Firmicutes yhaI Bacteria 1V90R@1239,COG3152@1,COG3152@2 NA|NA|NA J Membrane HLLCKODE_01626 1046629.Ssal_00333 3.8e-61 240.7 Bacilli yhaI Bacteria 1V90R@1239,4HQ7Q@91061,COG3152@1,COG3152@2 NA|NA|NA J Protein of unknown function (DUF805) HLLCKODE_01627 1046629.Ssal_00333 2.7e-43 181.4 Bacilli yhaI Bacteria 1V90R@1239,4HQ7Q@91061,COG3152@1,COG3152@2 NA|NA|NA J Protein of unknown function (DUF805) HLLCKODE_01629 264199.stu1704 8.1e-95 354.0 Bacilli Bacteria 1W5UA@1239,2DDKD@1,2ZIF1@2,4HZND@91061 NA|NA|NA HLLCKODE_01630 322159.STER_1668 3.9e-173 614.0 Bacilli rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 ko00000,ko01000,ko03009 Bacteria 1TNZV@1239,4H9U2@91061,COG0275@1,COG0275@2 NA|NA|NA J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA HLLCKODE_01631 435842.HMPREF0848_01354 2.4e-45 188.0 Bacilli ftsL Bacteria 1VCE5@1239,4HM4W@91061,COG4839@1,COG4839@2 NA|NA|NA D cell division protein FtsL HLLCKODE_01632 435842.HMPREF0848_01353 0.0 1415.2 Bacilli ftsI GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031226,GO:0031406,GO:0032153,GO:0033218,GO:0033293,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:1901363,GO:1901681 3.4.16.4 ko:K03587,ko:K08384,ko:K08724,ko:K12552,ko:K12556 ko00550,ko01100,ko01501,map00550,map01100,map01501 ko00000,ko00001,ko01000,ko01011,ko03036 iSSON_1240.SSON_0092 Bacteria 1TP93@1239,4H9VQ@91061,COG0768@1,COG0768@2 NA|NA|NA M penicillin-binding protein HLLCKODE_01633 1046629.Ssal_00341 1.1e-184 652.5 Bacilli mraY GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 iAF987.Gmet_0409,iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105 Bacteria 1TP8W@1239,4H9TP@91061,COG0472@1,COG0472@2 NA|NA|NA M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan HLLCKODE_01634 1046629.Ssal_00342 9.8e-221 772.7 Bacilli cshB GO:0000166,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0008026,GO:0008144,GO:0008150,GO:0008152,GO:0008186,GO:0009266,GO:0009295,GO:0009409,GO:0009628,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0070035,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901363 3.6.4.13 ko:K05592,ko:K18692 ko03018,map03018 ko00000,ko00001,ko01000,ko03009,ko03019 Bacteria 1TPAP@1239,4HA98@91061,COG0513@1,COG0513@2 NA|NA|NA JKL DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures HLLCKODE_01637 1046629.Ssal_00344 3.1e-259 900.6 Bacilli yunD 3.1.3.5 ko:K01081 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 Bacteria 1TQCW@1239,4HAUC@91061,COG0737@1,COG0737@2 NA|NA|NA F Belongs to the 5'-nucleotidase family HLLCKODE_01638 435842.HMPREF0848_01344 5.6e-63 247.7 Bacilli yutD Bacteria 1VA85@1239,4HKF7@91061,COG4470@1,COG4470@2 NA|NA|NA J protein conserved in bacteria HLLCKODE_01639 1046629.Ssal_00347 1.8e-223 781.6 Bacilli rlmN GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 ko:K06941 ko00000,ko01000,ko03009 Bacteria 1TPVF@1239,4H9NU@91061,COG0820@1,COG0820@2 NA|NA|NA J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HLLCKODE_01640 1046629.Ssal_00348 6.3e-88 330.1 Bacilli XK27_09885 Bacteria 1VKIA@1239,4HQZW@91061,COG4767@1,COG4767@2 NA|NA|NA V Glycopeptide antibiotics resistance protein HLLCKODE_01642 1046629.Ssal_00350 0.0 1092.4 Bacilli mdlA GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0016021,GO:0017076,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044425,GO:0044464,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363 ko:K06148,ko:K18889 ko02010,map02010 M00707 ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.106.13,3.A.1.106.5 Bacteria 1TP0B@1239,4HA3S@91061,COG1132@1,COG1132@2 NA|NA|NA V abc transporter atp-binding protein HLLCKODE_01643 435842.HMPREF0848_01339 0.0 1081.6 Bacilli mdlB GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008144,GO:0008150,GO:0010876,GO:0015399,GO:0015405,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0033036,GO:0034040,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043492,GO:0044425,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363 ko:K06147,ko:K18890 ko02010,map02010 M00707 ko00000,ko00001,ko00002,ko02000 3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21 Bacteria 1TP0B@1239,4HA3S@91061,COG1132@1,COG1132@2 NA|NA|NA V abc transporter atp-binding protein HLLCKODE_01650 322159.STER_1636 1.8e-44 184.9 Bacteria spiA ko:K18831 ko00000,ko02048,ko03000 Bacteria COG1476@1,COG1476@2 NA|NA|NA K sequence-specific DNA binding HLLCKODE_01651 435842.HMPREF0848_01317 0.0 1463.0 Bacilli pepX 3.4.14.11 ko:K01281 ko00000,ko01000,ko01002 Bacteria 1TT78@1239,4HBA0@91061,COG2936@1,COG2936@2 NA|NA|NA E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline HLLCKODE_01652 264199.stu1671 2.5e-158 564.7 Bacilli gla ko:K02440 ko00000,ko02000 1.A.8.1,1.A.8.2 Bacteria 1TP4T@1239,4HE39@91061,COG0580@1,COG0580@2 NA|NA|NA U Belongs to the MIP aquaporin (TC 1.A.8) family HLLCKODE_01653 1046629.Ssal_00366 5.5e-97 360.5 Bacteria ko:K07052 ko00000 Bacteria COG1266@1,COG1266@2 NA|NA|NA V CAAX protease self-immunity HLLCKODE_01654 1046629.Ssal_00367 3.5e-140 504.2 Bacilli cppA Bacteria 1VMPM@1239,4HSVM@91061,COG0346@1,COG0346@2 NA|NA|NA E CppA N-terminal HLLCKODE_01655 1046629.Ssal_00368 6.7e-173 613.2 Bacilli ampC Bacteria 1TNZX@1239,4IPJT@91061,COG1680@1,COG1680@2 NA|NA|NA V COG1680 Beta-lactamase class C and other penicillin binding proteins HLLCKODE_01657 435842.HMPREF0848_01310 4.9e-73 280.4 Bacilli yjcF ko:K02348 ko00000 Bacteria 1VA2J@1239,4HKF5@91061,COG2153@1,COG2153@2 NA|NA|NA S COG0454 Histone acetyltransferase HPA2 and related acetyltransferases HLLCKODE_01658 1046629.Ssal_00372 1.2e-140 505.8 Bacilli cah 4.2.1.1 ko:K01674 ko00910,map00910 R00132,R10092 RC02807 ko00000,ko00001,ko01000 Bacteria 1V16J@1239,4HA62@91061,COG3338@1,COG3338@2 NA|NA|NA P carbonic anhydrase HLLCKODE_01659 1046629.Ssal_00375 0.0 1575.8 Bacilli pflB 2.3.1.54 ko:K00656 ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 R00212,R06987 RC00004,RC01181,RC02742,RC02833 ko00000,ko00001,ko01000 Bacteria 1TPTF@1239,4H9RD@91061,COG1882@1,COG1882@2 NA|NA|NA C formate acetyltransferase' HLLCKODE_01660 904306.HMPREF9192_0701 1.2e-202 712.2 Bacilli dinB GO:0000731,GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016604,GO:0016607,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019985,GO:0031668,GO:0031974,GO:0031981,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0035770,GO:0036464,GO:0042276,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0070013,GO:0071496,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1990904 2.7.7.7 ko:K02346 ko00000,ko01000,ko03400 Bacteria 1TP42@1239,4HADJ@91061,COG0389@1,COG0389@2 NA|NA|NA L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII HLLCKODE_01661 888049.HMPREF8578_1185 1e-34 154.1 Streptococcus oralis Bacteria 1TWTB@1239,1WP3D@1303,2DJ1D@1,304JE@2,4I5MI@91061 NA|NA|NA HLLCKODE_01662 1046629.Ssal_00380 9.7e-152 542.7 Bacilli yxeM ko:K02030,ko:K16957 ko02010,map02010 M00236,M00585 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.13 Bacteria 1V7WQ@1239,4HK1Z@91061,COG0834@1,COG0834@2 NA|NA|NA ET ABC-type amino acid transport signal transduction systems, periplasmic component domain HLLCKODE_01663 264199.stu1653 5.2e-162 577.0 Bacilli yxeN ko:K02029,ko:K16959,ko:K16962 ko02010,map02010 M00236,M00585,M00586 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.13 Bacteria 1UZ2C@1239,4HF77@91061,COG0765@1,COG0765@2 NA|NA|NA P ABC transporter (Permease HLLCKODE_01664 904306.HMPREF9192_0705 3.6e-129 467.6 Bacilli tcyN 3.6.3.21 ko:K02028,ko:K10010,ko:K16960,ko:K16963 ko02010,map02010 M00234,M00236,M00585,M00586 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.10,3.A.1.3.13,3.A.1.3.14 Bacteria 1TNYD@1239,4H9WY@91061,COG1126@1,COG1126@2 NA|NA|NA E abc transporter atp-binding protein HLLCKODE_01665 1005705.HMPREF9967_0788 5e-10 70.1 Streptococcus infantis Bacteria 1TWHK@1239,2DIY2@1,304CK@2,43GAW@68892,4I5AY@91061 NA|NA|NA S Protein of unknown function (DUF4059) HLLCKODE_01666 1046629.Ssal_00386 2.1e-171 608.2 Bacilli trxB 1.8.1.9 ko:K00384 ko00450,map00450 R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 Bacteria 1TNZS@1239,4HA4N@91061,COG0492@1,COG0492@2 NA|NA|NA C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family HLLCKODE_01667 435842.HMPREF0848_01291 2.1e-91 341.7 Bacilli rsmD 2.1.1.171 ko:K08316 R07234 RC00003 ko00000,ko01000,ko03009 Bacteria 1V3JF@1239,4HGXT@91061,COG0742@1,COG0742@2 NA|NA|NA L Methyltransferase HLLCKODE_01668 1046629.Ssal_00388 1.7e-87 328.6 Bacilli coaD 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 1V3MR@1239,4HH47@91061,COG0669@1,COG0669@2 NA|NA|NA H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate HLLCKODE_01669 264199.stu1647 1.1e-187 662.5 Bacilli ylbL ko:K07177 ko02024,map02024 ko00000,ko00001,ko01002 Bacteria 1TRUF@1239,4HBAY@91061,COG3480@1,COG3480@2 NA|NA|NA T Belongs to the peptidase S16 family HLLCKODE_01670 904306.HMPREF9192_0713 2.7e-182 644.4 Bacilli yhcC GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464,GO:0048037,GO:0051536,GO:0051539,GO:0051540 ko:K07139 ko00000 Bacteria 1TQ57@1239,4H9N8@91061,COG1242@1,COG1242@2 NA|NA|NA S radical SAM protein HLLCKODE_01671 264199.stu1645 9.4e-95 352.8 Bacilli ytqB 2.1.1.176 ko:K03500 ko00000,ko01000,ko03009 Bacteria 1UHQD@1239,4HIMC@91061,COG0144@1,COG0144@2 NA|NA|NA J (SAM)-dependent HLLCKODE_01673 1046629.Ssal_00394 0.0 1251.9 Bacilli yjcE GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006814,GO:0006873,GO:0006885,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015079,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015386,GO:0015491,GO:0015672,GO:0016020,GO:0019725,GO:0022804,GO:0022821,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0035725,GO:0042592,GO:0044464,GO:0046873,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098657,GO:0098659,GO:0098660,GO:0098662,GO:0098719,GO:0098739,GO:0098771,GO:0099516,GO:0099587,GO:1902600 ko:K03316 ko00000 2.A.36 Bacteria 1TR4G@1239,4HBJR@91061,COG0025@1,COG0025@2 NA|NA|NA P NhaP-type Na H and K H antiporters HLLCKODE_01674 1046629.Ssal_00395 1.5e-141 508.8 Bacilli modF GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 3.6.3.21,3.6.3.34 ko:K02013,ko:K02028,ko:K05776 ko02010,map02010 M00189,M00236,M00240 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14,3.A.1.3 Bacteria 1TRR4@1239,4HB4U@91061,COG1119@1,COG1119@2 NA|NA|NA P abc transporter atp-binding protein HLLCKODE_01675 1046629.Ssal_00397 1.9e-237 828.2 Bacilli hlyX ko:K03699 ko00000,ko02042 Bacteria 1TPN0@1239,4H9SB@91061,COG1253@1,COG1253@2 NA|NA|NA S COG1253 Hemolysins and related proteins containing CBS domains HLLCKODE_01676 1000570.HMPREF9966_1907 6.2e-09 68.2 Streptococcus anginosus group ko:K06236 ko04151,ko04510,ko04512,ko04611,ko04926,ko04933,ko04974,ko05146,ko05165,map04151,map04510,map04512,map04611,map04926,map04933,map04974,map05146,map05165 ko00000,ko00001,ko00536,ko04516 Bacteria 1UMUJ@1239,42EFA@671232,4IU0F@91061,COG3468@1,COG3468@2 NA|NA|NA MU outer membrane autotransporter barrel domain protein HLLCKODE_01677 1046629.Ssal_00399 1.5e-157 562.0 Bacilli pflA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0018307,GO:0019538,GO:0033554,GO:0036211,GO:0043170,GO:0043364,GO:0043365,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0055114,GO:0070283,GO:0071704,GO:1901564 1.97.1.4 ko:K04069 R04710 ko00000,ko01000 iECOK1_1307.ECOK1_0925,iEcE24377_1341.EcE24377A_0980,iEcSMS35_1347.EcSMS35_2219,iYL1228.KPN_00930 Bacteria 1TPK2@1239,4HACV@91061,COG1180@1,COG1180@2 NA|NA|NA C Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine HLLCKODE_01679 1046629.Ssal_00402 1.2e-74 285.8 Bacilli XK27_03180 ko:K03499,ko:K06149 ko00000,ko02000 2.A.38.1,2.A.38.4 Bacteria 1V3NY@1239,4HIP3@91061,COG0589@1,COG0589@2 NA|NA|NA T universal stress protein HLLCKODE_01680 1046629.Ssal_00403 1.7e-237 828.2 Bacilli alaA GO:0003674,GO:0003824,GO:0004021,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006090,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016769,GO:0019272,GO:0019752,GO:0019842,GO:0030170,GO:0030632,GO:0032787,GO:0033554,GO:0036094,GO:0040007,GO:0042221,GO:0042851,GO:0042852,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0046677,GO:0047635,GO:0048037,GO:0050662,GO:0050896,GO:0051716,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.2,2.6.1.66 ko:K00814,ko:K14260 ko00220,ko00250,ko00290,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00220,map00250,map00290,map00710,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00171 R00258,R01215 RC00006,RC00008,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 iNJ661.Rv0337c Bacteria 1TP0J@1239,4HD83@91061,COG0436@1,COG0436@2 NA|NA|NA E Aminotransferase HLLCKODE_01681 1046629.Ssal_00404 8.1e-140 503.1 Bacilli codY GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0044424,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 ko:K03706 ko00000,ko03000 Bacteria 1TS7A@1239,4HA9U@91061,COG4465@1,COG4465@2 NA|NA|NA K DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor HLLCKODE_01682 322159.STER_1598 4.4e-100 370.5 Bacilli pncA ko:K16788 ko00000,ko02000 2.A.88.5 iSB619.SA_RS09955 Bacteria 1V1CY@1239,4HFRS@91061,COG1335@1,COG1335@2 NA|NA|NA Q isochorismatase HLLCKODE_01683 904306.HMPREF9192_0728 6.4e-292 1009.2 Bacilli ascB 3.2.1.86 ko:K01223 ko00010,ko00500,map00010,map00500 R00839,R05133,R05134 RC00049,RC00171,RC00714 ko00000,ko00001,ko01000 GT1 Bacteria 1TP19@1239,4HA1W@91061,COG2723@1,COG2723@2 NA|NA|NA G Belongs to the glycosyl hydrolase 1 family HLLCKODE_01684 435842.HMPREF0848_01271 6.7e-218 763.1 Bacteria Bacteria COG1442@1,COG1442@2 NA|NA|NA M lipopolysaccharide 3-alpha-galactosyltransferase activity HLLCKODE_01685 435842.HMPREF0848_01270 6.3e-157 560.1 Firmicutes Bacteria 1V7WV@1239,COG1216@1,COG1216@2 NA|NA|NA H COG0463 Glycosyltransferases involved in cell wall biogenesis HLLCKODE_01686 435842.HMPREF0848_01269 1.1e-189 669.5 Firmicutes Bacteria 1TQZR@1239,COG0438@1,COG0438@2 NA|NA|NA M A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1 HLLCKODE_01687 435842.HMPREF0848_01268 5.8e-232 810.1 Bacilli 2.4.1.52 ko:K00712 ko00000,ko01000,ko01003 GT4 Bacteria 1TR6K@1239,4HGDG@91061,COG0438@1,COG0438@2 NA|NA|NA M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon HLLCKODE_01688 1046629.Ssal_00409 5.3e-47 193.4 Bacilli gatC 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 iAF987.Gmet_0076 Bacteria 1VEK3@1239,4HNNA@91061,COG0721@1,COG0721@2 NA|NA|NA J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) HLLCKODE_01689 904306.HMPREF9192_0732 2.5e-267 927.5 Bacilli gatA 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 Bacteria 1TP0C@1239,4HBAZ@91061,COG0154@1,COG0154@2 NA|NA|NA J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) HLLCKODE_01690 888048.HMPREF8577_1136 6.6e-273 946.0 Bacilli gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.12,6.3.5.6,6.3.5.7 ko:K01876,ko:K02434 ko00970,ko01100,map00970,map01100 M00359,M00360 R03905,R04212,R05577 RC00010,RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Bacteria 1TPG3@1239,4HAFB@91061,COG0064@1,COG0064@2 NA|NA|NA J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) HLLCKODE_01691 861455.HMPREF9184_01629 8.1e-88 329.7 Bacilli tag 3.2.2.20 ko:K01246 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 1V63S@1239,4IPT0@91061,COG2818@1,COG2818@2 NA|NA|NA L glycosylase HLLCKODE_01692 1008453.HMPREF9957_1515 4.9e-41 173.3 Streptococcus mitis ko:K15383 ko00000,ko02000 9.A.58.2 Bacteria 1VCDB@1239,2TPVS@28037,4HX7U@91061,COG4095@1,COG4095@2 NA|NA|NA S Sugar efflux transporter for intercellular exchange HLLCKODE_01693 1046629.Ssal_01307 0.0 2717.2 Bacilli 2.4.1.5 ko:K00689,ko:K20276 ko00500,ko02020,ko02024,map00500,map02020,map02024 R02120,R06066 RC00028 ko00000,ko00001,ko01000 GH13 Bacteria 1VQXK@1239,4HEIA@91061,COG0366@1,COG0366@2,COG5263@1,COG5263@2 NA|NA|NA M KxYKxGKxW signal domain protein HLLCKODE_01694 904306.HMPREF9192_1554 7.1e-227 793.1 Bacilli rodA ko:K05837 ko00000,ko03036 Bacteria 1TPGH@1239,4HAV4@91061,COG0772@1,COG0772@2 NA|NA|NA D Belongs to the SEDS family HLLCKODE_01695 1046629.Ssal_01305 3.5e-244 850.5 Bacilli hflX GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0043021,GO:0043022,GO:0044424,GO:0044464,GO:0044877 ko:K03665 ko00000,ko03009 Bacteria 1TNZB@1239,4HACA@91061,COG2262@1,COG2262@2 NA|NA|NA S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis HLLCKODE_01696 904306.HMPREF9192_1556 2.6e-112 411.4 Bacilli galT 2.7.7.12 ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 M00362,M00554,M00632 R00955 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 1VY8D@1239,4HXPD@91061,COG4468@1,COG4468@2 NA|NA|NA G UDPglucose--hexose-1-phosphate uridylyltransferase HLLCKODE_01697 904306.HMPREF9192_1557 4.6e-174 617.1 Bacilli rnz GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004527,GO:0004532,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016891,GO:0016893,GO:0016896,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043169,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0090503,GO:0140098,GO:1901360,GO:1905267 3.1.26.11 ko:K00784 ko03013,map03013 ko00000,ko00001,ko01000,ko03016 Bacteria 1TRGP@1239,4HABM@91061,COG1234@1,COG1234@2 NA|NA|NA S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA HLLCKODE_01698 904306.HMPREF9192_1558 4.3e-138 497.3 Bacilli XK27_05435 1.1.1.100 ko:K00059,ko:K07124 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 1TSJ3@1239,4HDU5@91061,COG0300@1,COG0300@2 NA|NA|NA S Belongs to the short-chain dehydrogenases reductases (SDR) family HLLCKODE_01699 1046629.Ssal_01301 3.2e-127 461.1 Bacilli Bacteria 1V1BN@1239,4HPJN@91061,COG0500@1,COG0500@2 NA|NA|NA Q Methyltransferase domain HLLCKODE_01700 904306.HMPREF9192_1559 1.2e-65 255.8 Bacteria GnaT 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 Bacteria COG0454@1,COG0456@2 NA|NA|NA K acetyltransferase HLLCKODE_01701 1046629.Ssal_01299 0.0 1441.0 Bacilli recJ ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 1TPXE@1239,4H9UP@91061,COG0608@1,COG0608@2,COG4199@1,COG4199@2 NA|NA|NA L Single-strand DNA-specific exonuclease, C terminal domain HLLCKODE_01702 904306.HMPREF9192_1561 1.7e-93 348.6 Bacilli apt GO:0003674,GO:0003824,GO:0003999,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006168,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 Bacteria 1V1BV@1239,4HFUA@91061,COG0503@1,COG0503@2 NA|NA|NA F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis HLLCKODE_01703 1046629.Ssal_01297 1.8e-181 641.7 Bacilli metA GO:0003674,GO:0003824,GO:0008374,GO:0008899,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016750 2.3.1.46 ko:K00651 ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230 M00017 R01777 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQVR@1239,4H9W4@91061,COG1897@1,COG1897@2 NA|NA|NA E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine HLLCKODE_01704 1046629.Ssal_01296 1.3e-125 455.7 Bacteria dnaD ko:K02086 ko00000 Bacteria COG3935@1,COG3935@2 NA|NA|NA HLLCKODE_01705 1046629.Ssal_01295 1.3e-119 435.6 Bacilli nth 4.2.99.18 ko:K10773 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 1TRAK@1239,4HATD@91061,COG0177@1,COG0177@2 NA|NA|NA L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate HLLCKODE_01707 1046629.Ssal_01292 6.2e-233 813.1 Bacilli xseA 3.1.11.6 ko:K03601 ko03430,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 1TP4E@1239,4HAN2@91061,COG1570@1,COG1570@2 NA|NA|NA L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides HLLCKODE_01708 435842.HMPREF0848_00499 4.6e-29 133.3 Firmicutes xseB 3.1.11.6 ko:K03602 ko03430,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 1VK9I@1239,COG1722@1,COG1722@2 NA|NA|NA L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides HLLCKODE_01709 1046629.Ssal_01290 5.2e-156 557.0 Bacilli ispA GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0071704,GO:1901576 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 ko:K00795,ko:K02523,ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061,R09248 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 Bacteria 1TPQY@1239,4HA8E@91061,COG0142@1,COG0142@2 NA|NA|NA H Belongs to the FPP GGPP synthase family HLLCKODE_01710 1046629.Ssal_01289 1.5e-147 528.9 Bacilli rrmJ 2.1.1.226,2.1.1.227 ko:K06442 ko00000,ko01000,ko03009 Bacteria 1TPE4@1239,4HAPY@91061,COG1189@1,COG1189@2 NA|NA|NA J Ribosomal RNA large subunit methyltransferase J HLLCKODE_01711 1046629.Ssal_01288 2.8e-73 281.2 Bacilli argR GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 ko:K03402 ko00000,ko03000 Bacteria 1V1R7@1239,4HFY8@91061,COG1438@1,COG1438@2 NA|NA|NA K Regulates arginine biosynthesis genes HLLCKODE_01712 1046629.Ssal_01287 5.6e-300 1036.2 Bacilli recN GO:0000724,GO:0000725,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009295,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:1901360 ko:K03631,ko:K13582 ko04112,map04112 ko00000,ko00001,ko03400 Bacteria 1TP99@1239,4H9ZR@91061,COG0497@1,COG0497@2 NA|NA|NA L May be involved in recombinational repair of damaged DNA HLLCKODE_01713 1046629.Ssal_01286 1.5e-144 518.8 Bacilli DegV Bacteria 1TRZ4@1239,4HBR8@91061,COG1307@1,COG1307@2 NA|NA|NA S DegV family HLLCKODE_01714 1046629.Ssal_01285 3.1e-156 557.8 Bacilli ypmR GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0016298,GO:0016787,GO:0016788,GO:0052689 Bacteria 1V1HR@1239,4HDXS@91061,COG2755@1,COG2755@2 NA|NA|NA E COG2755 Lysophospholipase L1 and related esterases HLLCKODE_01715 1046629.Ssal_01284 3.4e-95 354.4 Bacilli ypmS Bacteria 1VF0K@1239,4HIYN@91061,COG4698@1,COG4698@2 NA|NA|NA S Protein conserved in bacteria HLLCKODE_01716 1046629.Ssal_01283 6.3e-39 166.4 Bacilli hup ko:K03530 ko00000,ko03032,ko03036,ko03400 Bacteria 1V9XQ@1239,4HKF2@91061,COG0776@1,COG0776@2 NA|NA|NA L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions HLLCKODE_01718 1046629.Ssal_01281 1.4e-178 632.1 Bacilli pyrD GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.98.1 ko:K00226,ko:K02823,ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01867,R01869 RC00051 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPFV@1239,4HBFE@91061,COG0167@1,COG0167@2 NA|NA|NA F Catalyzes the conversion of dihydroorotate to orotate HLLCKODE_01719 997830.HMPREF1124_2001 3.6e-131 474.2 Streptococcus infantis gpmA GO:0001871,GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009986,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030246,GO:0030247,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031,GO:2001065 5.4.2.11 ko:K01834 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 Bacteria 1TQFP@1239,43G3N@68892,4HAW7@91061,COG0588@1,COG0588@2 NA|NA|NA G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate HLLCKODE_01720 999425.HMPREF9186_01824 5.4e-53 213.4 Bacilli hxlR Bacteria 1VA9M@1239,4HNIX@91061,COG1733@1,COG1733@2 NA|NA|NA K HxlR-like helix-turn-helix HLLCKODE_01721 1046629.Ssal_01278 2e-70 271.6 Bacilli ko:K06893 ko00000 Bacteria 1V9T9@1239,4HWFN@91061,COG3631@1,COG3631@2 NA|NA|NA S SnoaL-like polyketide cyclase HLLCKODE_01722 435842.HMPREF0848_00511 2.1e-288 997.7 Bacilli leuA 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS10690,iYO844.BSU28280 Bacteria 1TP4Y@1239,4HA6E@91061,COG0119@1,COG0119@2 NA|NA|NA E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) HLLCKODE_01723 1046629.Ssal_01275 2.3e-187 661.4 Bacilli leuB GO:0003674,GO:0003824,GO:0003862,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1TPEM@1239,4HATP@91061,COG0473@1,COG0473@2 NA|NA|NA CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate HLLCKODE_01724 1046629.Ssal_01273 4.7e-276 956.4 Bacilli leuC GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 iEcE24377_1341.EcE24377A_0075,iPC815.YPO0531,iSB619.SA_RS10700 Bacteria 1TPE5@1239,4HAWA@91061,COG0065@1,COG0065@2 NA|NA|NA E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate HLLCKODE_01725 1046629.Ssal_01272 2.4e-112 411.4 Bacilli leuD 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1V1I6@1239,4HFTY@91061,COG0066@1,COG0066@2 NA|NA|NA E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate HLLCKODE_01726 904306.HMPREF9192_0403 1.8e-221 775.0 Firmicutes Bacteria 1VQIX@1239,COG3464@1,COG3464@2 NA|NA|NA L the current gene model (or a revised gene model) may contain a frame shift HLLCKODE_01727 1046629.Ssal_00953 5.9e-169 600.1 Bacilli yufQ ko:K02057 M00221 ko00000,ko00002,ko02000 3.A.1.2 Bacteria 1TP8Y@1239,4HAX4@91061,COG1079@1,COG1079@2 NA|NA|NA S Belongs to the binding-protein-dependent transport system permease family HLLCKODE_01728 435842.HMPREF0848_00801 2.3e-177 628.2 Bacilli yufP GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0044425,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944 ko:K02057 M00221 ko00000,ko00002,ko02000 3.A.1.2 Bacteria 1TP1F@1239,4H9VE@91061,COG4603@1,COG4603@2 NA|NA|NA S Belongs to the binding-protein-dependent transport system permease family HLLCKODE_01729 435842.HMPREF0848_00802 4.6e-280 969.9 Bacilli xylG 3.6.3.17 ko:K02056,ko:K06400 M00221 ko00000,ko00002,ko01000,ko02000 3.A.1.2 Bacteria 1UYQA@1239,4HVSH@91061,COG3845@1,COG3845@2 NA|NA|NA S ABC transporter, ATP-binding protein HLLCKODE_01730 1046629.Ssal_00950 2.3e-190 671.4 Bacilli tcsA ko:K02058,ko:K07335 M00221 ko00000,ko00002,ko02000 3.A.1.2 Bacteria 1TPEU@1239,4HF7R@91061,COG1744@1,COG1744@2 NA|NA|NA S membrane HLLCKODE_01731 1046629.Ssal_00949 1.3e-64 252.3 Bacilli cdd 2.4.2.2,3.5.4.5 ko:K00756,ko:K01489 ko00240,ko00983,ko01100,map00240,map00983,map01100 R01570,R01876,R01878,R02296,R02484,R02485,R08221 RC00063,RC00074,RC00514 ko00000,ko00001,ko01000 iSB619.SA_RS07895 Bacteria 1V6IP@1239,4HIJ3@91061,COG0295@1,COG0295@2 NA|NA|NA F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis HLLCKODE_01732 1046629.Ssal_00948 1.8e-111 408.7 Bacilli deoC GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 4.1.2.4,5.4.2.8 ko:K01619,ko:K01840 ko00030,ko00051,ko00520,ko01100,ko01110,ko01130,map00030,map00051,map00520,map01100,map01110,map01130 M00114 R01066,R01818 RC00408,RC00436,RC00437 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS00835 Bacteria 1TPAJ@1239,4HAAJ@91061,COG0274@1,COG0274@2 NA|NA|NA F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate HLLCKODE_01733 1046629.Ssal_00947 1.3e-227 795.4 Bacilli pdp GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016757,GO:0016758,GO:0044424,GO:0044444,GO:0044464 2.4.2.2,2.4.2.4 ko:K00756,ko:K00758 ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219 R01570,R01876,R02296,R02484,R08222,R08230 RC00063 ko00000,ko00001,ko01000 Bacteria 1TPCH@1239,4H9NP@91061,COG0213@1,COG0213@2 NA|NA|NA F Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate HLLCKODE_01734 1046629.Ssal_00946 1.7e-105 388.7 Bacilli rsmC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044464 2.1.1.172 ko:K00564 R07234 RC00003 ko00000,ko01000,ko03009 Bacteria 1V3JX@1239,4IR00@91061,COG2813@1,COG2813@2 NA|NA|NA J Methyltransferase small domain protein HLLCKODE_01735 1046629.Ssal_00945 2.8e-171 607.8 Bacilli coaA GO:0003674,GO:0003824,GO:0004594,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.33 ko:K00867 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 iECDH1ME8569_1439.ECDH1ME8569_3838,iECH74115_1262.ECH74115_5439,iECSE_1348.ECSE_4265,iECSF_1327.ECSF_3833,iECSP_1301.ECSP_5045,iECW_1372.ECW_m4332,iEcDH1_1363.EcDH1_4016,iEcolC_1368.EcolC_4046,iPC815.YPO3758,iSFV_1184.SFV_4047,iSFxv_1172.SFxv_4418,iWFL_1372.ECW_m4332,iZ_1308.Z5545 Bacteria 1TPHJ@1239,4HA4K@91061,COG1072@1,COG1072@2 NA|NA|NA F Pantothenic acid kinase HLLCKODE_01736 904306.HMPREF9192_1235 1e-29 135.6 Bacilli rpsT GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02968 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1VEGX@1239,4HNJS@91061,COG0268@1,COG0268@2 NA|NA|NA J Binds directly to 16S ribosomal RNA HLLCKODE_01737 904306.HMPREF9192_1234 1.3e-241 842.0 Bacilli Bacteria 1UHNC@1239,4IS4A@91061,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor HLLCKODE_01738 1046629.Ssal_00942 9.4e-121 439.5 Bacilli Bacteria 1V295@1239,4HG3X@91061,COG0745@1,COG0745@2 NA|NA|NA T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain HLLCKODE_01739 1046629.Ssal_00941 0.0 1093.6 Bacilli fhs GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP6N@1239,4HA2X@91061,COG2759@1,COG2759@2 NA|NA|NA F Belongs to the formate--tetrahydrofolate ligase family HLLCKODE_01740 1046629.Ssal_00940 4.6e-115 420.6 Bacilli coaB 4.1.1.36,6.3.2.5 ko:K01598,ko:K13038,ko:K21977 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 Bacteria 1V7YG@1239,4HMIF@91061,COG0452@1,COG0452@2 NA|NA|NA H Phosphopantothenate-cysteine ligase HLLCKODE_01741 1046629.Ssal_00939 9.7e-92 342.8 Bacilli coaBC 4.1.1.36,6.3.2.5 ko:K01598,ko:K13038,ko:K21977 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPP3@1239,4HAK8@91061,COG0452@1,COG0452@2 NA|NA|NA H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine HLLCKODE_01742 1046629.Ssal_00938 3.9e-91 340.9 Bacilli panT GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 1V2M1@1239,4HFPD@91061,COG4684@1,COG4684@2 NA|NA|NA S ECF transporter, substrate-specific component HLLCKODE_01743 1046629.Ssal_00935 0.0 1118.2 Bacilli pgm GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 5.4.2.2,5.4.2.8 ko:K01835,ko:K01840 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114,M00549 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP2N@1239,4HADU@91061,COG1109@1,COG1109@2 NA|NA|NA G Phosphoglucomutase HLLCKODE_01744 1046629.Ssal_00934 1.6e-165 588.6 Firmicutes metF GO:0000166,GO:0003674,GO:0003824,GO:0004489,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019438,GO:0019752,GO:0022607,GO:0034641,GO:0036094,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.5.1.20 ko:K00297,ko:K21010 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,ko02025,map00670,map00720,map01100,map01120,map01200,map01523,map02025 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 iPC815.YPO0117,iSBO_1134.SBO_3961 Bacteria 1TQFE@1239,COG0685@1,COG0685@2 NA|NA|NA E reductase HLLCKODE_01745 1046629.Ssal_00933 0.0 1490.3 Bacilli metE GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003871,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0030312,GO:0032259,GO:0034641,GO:0035999,GO:0036211,GO:0040007,GO:0042084,GO:0042085,GO:0042558,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0050667,GO:0051186,GO:0071704,GO:0071944,GO:0140096,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 iE2348C_1286.E2348C_4130,iECO103_1326.ECO103_4334,iECO111_1330.ECO111_4657,iECO26_1355.ECO26_4756,iECW_1372.ECW_m4131,iEKO11_1354.EKO11_4528,iPC815.YPO3788,iWFL_1372.ECW_m4131 Bacteria 1TP2H@1239,4H9QC@91061,COG0620@1,COG0620@2 NA|NA|NA E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation HLLCKODE_01747 1046629.Ssal_00931 0.0 1107.8 Bacilli pabB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.6.1.85,4.1.3.27,4.1.3.38 ko:K01665,ko:K02619,ko:K03342,ko:K13503,ko:K13950 ko00400,ko00790,ko01100,ko01110,ko01130,ko01230,map00400,map00790,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01716,R05553 RC00010,RC01418,RC01843,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 1TQAP@1239,4HBKC@91061,COG0115@1,COG0115@2,COG0147@1,COG0147@2 NA|NA|NA EH component I HLLCKODE_01748 1046629.Ssal_00930 0.0 1625.5 Bacilli 3.6.3.8 ko:K01537,ko:K12955 ko00000,ko01000 3.A.3.2,3.A.3.24 Bacteria 1TPF5@1239,4H9S5@91061,COG0474@1,COG0474@2 NA|NA|NA P cation transport ATPase HLLCKODE_01749 1046629.Ssal_00929 1.1e-242 845.5 Bacilli dltD ko:K03740 ko01503,ko02020,ko05150,map01503,map02020,map05150 M00725 ko00000,ko00001,ko00002,ko01504 Bacteria 1TSZU@1239,4HC3H@91061,COG3966@1,COG3966@2 NA|NA|NA M Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) HLLCKODE_01750 1046629.Ssal_00928 2.2e-35 154.5 Bacilli dltC GO:0000270,GO:0003674,GO:0005215,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0006810,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0022857,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0051179,GO:0051234,GO:0055085,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.1.1.13 ko:K02078,ko:K14188 ko00473,ko01503,ko02020,ko05150,map00473,map01503,map02020,map05150 M00725 R02718 RC00037,RC00094 ko00000,ko00001,ko00002,ko01000,ko01504 Bacteria 1VFQI@1239,4HNIH@91061,COG0236@1,COG0236@2 NA|NA|NA IQ Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall HLLCKODE_01751 1046629.Ssal_00927 1.2e-235 822.0 Bacilli dltB ko:K03739 ko01503,ko02020,ko05150,map01503,map02020,map05150 M00725 ko00000,ko00001,ko00002,ko01504 Bacteria 1TP52@1239,4HBQG@91061,COG1696@1,COG1696@2 NA|NA|NA M Membrane protein involved in D-alanine export HLLCKODE_01752 1046629.Ssal_00926 4.2e-297 1026.5 Bacilli dltA GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0006810,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016208,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0022857,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0051179,GO:0051234,GO:0055085,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.13 ko:K03367 ko00473,ko01503,ko02020,ko05150,map00473,map01503,map02020,map05150 M00725 R02718 RC00037,RC00094 ko00000,ko00001,ko00002,ko01000,ko01504 Bacteria 1TPTH@1239,4HAHU@91061,COG1020@1,COG1020@2 NA|NA|NA Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall HLLCKODE_01753 1046629.Ssal_00924 0.0 1083.6 Bacilli XK27_10035 ko:K06147,ko:K11085 ko02010,map02010 ko00000,ko00001,ko01000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 1TP0B@1239,4HCVN@91061,COG1132@1,COG1132@2 NA|NA|NA V abc transporter atp-binding protein HLLCKODE_01754 1046629.Ssal_00923 1.4e-213 748.8 Bacilli yfiB1 ko:K06147,ko:K06148,ko:K18887 ko02010,map02010 M00706 ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 1TP0B@1239,4H9SC@91061,COG1132@1,COG1132@2 NA|NA|NA V abc transporter atp-binding protein HLLCKODE_01755 264199.stu0758 1.6e-68 265.4 Bacilli yfiB1 ko:K06147,ko:K06148,ko:K18887 ko02010,map02010 M00706 ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 1TP0B@1239,4H9SC@91061,COG1132@1,COG1132@2 NA|NA|NA V abc transporter atp-binding protein HLLCKODE_01756 264199.stu0757 5.4e-99 367.1 Bacteria pvaA ko:K02395 ko00000,ko02035 Bacteria COG0741@1,COG0741@2 NA|NA|NA M lytic transglycosylase activity HLLCKODE_01757 904306.HMPREF9192_1214 1.2e-177 629.0 Bacilli ndpA GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003723,GO:0003727,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0009295,GO:0042802,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044464,GO:0097159,GO:1901363 ko:K06899 ko00000,ko03036 Bacteria 1V437@1239,4IQXJ@91061,COG3081@1,COG3081@2 NA|NA|NA S 37-kD nucleoid-associated bacterial protein HLLCKODE_01758 904306.HMPREF9192_1213 4.6e-230 803.5 Bacilli glyA 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQVM@1239,4HA5K@91061,COG0112@1,COG0112@2 NA|NA|NA E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism HLLCKODE_01759 1046629.Ssal_00919 1.9e-104 385.2 Bacilli ywlC GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 2.7.7.87,3.1.3.48 ko:K01104,ko:K07566 R10463 RC00745 ko00000,ko01000,ko03009,ko03016 Bacteria 1TP1I@1239,4HA7W@91061,COG0009@1,COG0009@2 NA|NA|NA J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine HLLCKODE_01760 904306.HMPREF9192_1211 2.3e-140 505.0 Bacilli prmB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006304,GO:0006305,GO:0006306,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009007,GO:0009008,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0032775,GO:0034641,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0044728,GO:0046483,GO:0071704,GO:0090304,GO:0140096,GO:0140097,GO:1901360,GO:1901564 2.1.1.297,2.1.1.298 ko:K02493,ko:K07320 R10806 RC00003,RC03279 ko00000,ko01000,ko03009,ko03012 Bacteria 1TSMA@1239,4HC6W@91061,COG2890@1,COG2890@2 NA|NA|NA J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif HLLCKODE_01761 1046629.Ssal_00917 3.6e-191 674.1 Bacilli prfA ko:K02835 ko00000,ko03012 Bacteria 1TQ7V@1239,4H9MB@91061,COG0216@1,COG0216@2 NA|NA|NA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA HLLCKODE_01762 904306.HMPREF9192_1209 1.9e-109 401.7 Bacilli tdk GO:0003674,GO:0003824,GO:0004797,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006259,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009120,GO:0009123,GO:0009124,GO:0009157,GO:0009162,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019136,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046104,GO:0046125,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0090304,GO:0090407,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.1.21 ko:K00857 ko00240,ko00983,ko01100,map00240,map00983,map01100 R01567,R02099,R08233 RC00002,RC00017 ko00000,ko00001,ko01000 iAF1260.b1238,iBWG_1329.BWG_1065,iECDH10B_1368.ECDH10B_1298,iECDH1ME8569_1439.ECDH1ME8569_1176,iEcDH1_1363.EcDH1_2411,iJO1366.b1238,iJR904.b1238,iPC815.YPO2176,iY75_1357.Y75_RS06470 Bacteria 1TRVM@1239,4HA4A@91061,COG1435@1,COG1435@2 NA|NA|NA F thymidine kinase HLLCKODE_01763 1046629.Ssal_00915 1.3e-182 645.6 Bacilli add 3.5.4.4 ko:K01488,ko:K02029 ko00230,ko01100,ko05340,map00230,map01100,map05340 M00236 R01560,R02556 RC00477 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3 iHN637.CLJU_RS13960 Bacteria 1U44B@1239,4HCES@91061,COG1816@1,COG1816@2 NA|NA|NA F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism HLLCKODE_01764 1046629.Ssal_00914 3.5e-151 540.8 Bacilli gst ko:K11209 ko00000,ko01000 Bacteria 1TPZ7@1239,4HD0K@91061,COG0625@1,COG0625@2 NA|NA|NA O Glutathione S-transferase HLLCKODE_01765 1046629.Ssal_00913 9.3e-175 619.4 Bacilli nrnA GO:0008150,GO:0040007 3.1.13.3,3.1.3.7 ko:K06881 ko00920,ko01100,ko01120,map00920,map01100,map01120 R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03400 Bacteria 1TPXX@1239,4H9ZW@91061,COG0618@1,COG0618@2 NA|NA|NA S domain protein HLLCKODE_01766 1046629.Ssal_00912 1.9e-172 611.7 Bacilli apbE 2.7.1.180 ko:K03734 ko00000,ko01000 Bacteria 1TR9C@1239,4HDFE@91061,COG1477@1,COG1477@2 NA|NA|NA H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein HLLCKODE_01767 1046629.Ssal_00910 4.4e-45 186.8 Bacilli rpmE2 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0034224,GO:0034641,GO:0034645,GO:0042594,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0120127,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02909 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1VEGU@1239,4HNQF@91061,COG0254@1,COG0254@2 NA|NA|NA J 50S ribosomal protein L31 HLLCKODE_01768 1046629.Ssal_00908 7.9e-230 802.7 Bacilli mntH Bacteria 1V04N@1239,4HBF6@91061,COG1914@1,COG1914@2 NA|NA|NA P Mn2 and Fe2 transporters of the NRAMP family HLLCKODE_01769 1046629.Ssal_00907 7.9e-161 573.2 Bacilli ypuA Bacteria 1TR2I@1239,4HBVZ@91061,COG4086@1,COG4086@2 NA|NA|NA S secreted protein HLLCKODE_01770 1046629.Ssal_00906 8.2e-72 276.2 Bacilli yaeR ko:K08234 ko00000 Bacteria 1V6XU@1239,4HIFI@91061,COG0346@1,COG0346@2 NA|NA|NA E COG0346 Lactoylglutathione lyase and related lyases HLLCKODE_01771 1046629.Ssal_00905 3.9e-131 474.2 Bacilli srtA 3.4.22.70 ko:K07284 ko00000,ko01000,ko01002,ko01011 Bacteria 1V83Z@1239,4HIA0@91061,COG3764@1,COG3764@2 NA|NA|NA M Sortase (surface protein transpeptidase) HLLCKODE_01772 1046629.Ssal_00904 0.0 1430.6 Bacilli gyrA GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 5.99.1.3 ko:K02469,ko:K02621 ko00000,ko01000,ko02048,ko03032,ko03036,ko03400 Bacteria 1TP2Z@1239,4HAHY@91061,COG0188@1,COG0188@2 NA|NA|NA L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner HLLCKODE_01773 1046629.Ssal_00903 1.6e-180 638.6 Bacilli ldh 1.1.1.27 ko:K00016 ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922 R00703,R01000,R03104 RC00031,RC00044 ko00000,ko00001,ko01000,ko04147 Bacteria 1TPSY@1239,4HB0Z@91061,COG0039@1,COG0039@2 NA|NA|NA C Belongs to the LDH MDH superfamily. LDH family HLLCKODE_01774 1046629.Ssal_00902 2.1e-252 877.9 Bacilli noxE Bacteria 1TPWW@1239,4H9U7@91061,COG0446@1,COG0446@2 NA|NA|NA P NADH oxidase HLLCKODE_01775 1046629.Ssal_00901 1.9e-294 1017.7 Bacilli yfmM ko:K06158 ko00000,ko03012 Bacteria 1TPAX@1239,4HC58@91061,COG0488@1,COG0488@2 NA|NA|NA S abc transporter atp-binding protein HLLCKODE_01776 1046629.Ssal_00900 5.4e-79 300.4 Bacilli XK27_01265 ko:K16923 M00582 ko00000,ko00002,ko02000 3.A.1.28 Bacteria 1VC0F@1239,4HMJM@91061,COG4720@1,COG4720@2 NA|NA|NA S ECF-type riboflavin transporter, S component HLLCKODE_01777 1046629.Ssal_00899 8.8e-148 529.6 Bacilli pdxK 2.7.1.35 ko:K00868 ko00750,ko01100,map00750,map01100 R00174,R01909,R02493 RC00002,RC00017 ko00000,ko00001,ko01000 Bacteria 1TRCR@1239,4HHME@91061,COG2240@1,COG2240@2 NA|NA|NA H Belongs to the pyridoxine kinase family HLLCKODE_01778 904306.HMPREF9192_1484 1.6e-83 315.5 Firmicutes Bacteria 1V6QK@1239,COG4720@1,COG4720@2 NA|NA|NA S ECF-type riboflavin transporter, S component HLLCKODE_01780 1046629.Ssal_00896 4.4e-236 823.5 Bacilli XK27_08130 Bacteria 1TPS5@1239,4HBNK@91061,COG1167@1,COG1167@2 NA|NA|NA K Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs HLLCKODE_01781 1046629.Ssal_00894 7e-56 223.0 Firmicutes nrdD_1 1.1.98.6,1.17.4.1 ko:K00525,ko:K21636 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024,R11633,R11634,R11635,R11636 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 Bacteria 1TT3U@1239,COG0209@1,COG0209@2 NA|NA|NA F Ribonucleoside-triphosphate reductase HLLCKODE_01783 1046629.Ssal_00892 0.0 1533.5 Bacilli pheT GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890,ko:K06878 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iG2583_1286.G2583_2160,iPC815.YPO2428 Bacteria 1TP98@1239,4HAQ9@91061,COG0072@1,COG0072@2,COG0073@1,COG0073@2 NA|NA|NA J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily HLLCKODE_01784 904306.HMPREF9192_1478 6.4e-93 346.7 Bacilli paiA 2.3.1.57 ko:K22441 ko00000,ko01000 Bacteria 1VDFK@1239,4HMHW@91061,COG0454@1,COG0456@2 NA|NA|NA K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases HLLCKODE_01785 1046629.Ssal_00890 3.9e-198 697.2 Bacilli pheS GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1TPFW@1239,4HAVN@91061,COG0016@1,COG0016@2 NA|NA|NA J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily HLLCKODE_01786 1000570.HMPREF9966_0177 7.3e-20 102.4 Streptococcus anginosus group WQ51_00220 ko:K07729 ko00000,ko03000 Bacteria 1VERT@1239,42DRV@671232,4HNKW@91061,COG1476@1,COG1476@2 NA|NA|NA K Helix-turn-helix domain HLLCKODE_01787 1046629.Ssal_00888 5.9e-89 333.6 Bacilli Bacteria 1VK6G@1239,2EQR3@1,33IAY@2,4HRX8@91061 NA|NA|NA S Protein of unknown function (DUF3278) HLLCKODE_01788 1046629.Ssal_00887 0.0 1362.4 Bacilli smc ko:K03529 ko00000,ko03036 Bacteria 1TPJV@1239,4HB89@91061,COG1196@1,COG1196@2 NA|NA|NA D Required for chromosome condensation and partitioning HLLCKODE_01789 1046629.Ssal_00886 9.3e-124 449.5 Bacilli rnc GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 Bacteria 1TPGC@1239,4HAWU@91061,COG0571@1,COG0571@2 NA|NA|NA J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism HLLCKODE_01790 1046629.Ssal_00884 1.9e-172 611.7 Bacilli dapA 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPCK@1239,4H9K9@91061,COG0329@1,COG0329@2 NA|NA|NA E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) HLLCKODE_01791 904306.HMPREF9192_1472 2.8e-199 701.0 Bacilli asd 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPC6@1239,4HA9H@91061,COG0136@1,COG0136@2 NA|NA|NA E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate HLLCKODE_01792 904306.HMPREF9192_1471 8.8e-124 449.5 Firmicutes alkD Bacteria 1V2U8@1239,COG4912@1,COG4912@2 NA|NA|NA L DNA alkylation repair enzyme HLLCKODE_01793 1046629.Ssal_00880 9.1e-292 1008.8 Bacilli cls ko:K06131,ko:K06915 ko00564,ko01100,map00564,map01100 R07390 RC00017 ko00000,ko00001,ko01000 Bacteria 1TPKY@1239,4H9TI@91061,COG1502@1,COG1502@2 NA|NA|NA I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol HLLCKODE_01794 904306.HMPREF9192_1469 6.3e-93 346.7 Bacilli pat 2.3.1.183 ko:K03823 ko00440,ko01130,map00440,map01130 R08871,R08938 RC00004,RC00064 ko00000,ko00001,ko01000 Bacteria 1V6X5@1239,4HIP1@91061,COG1247@1,COG1247@2 NA|NA|NA M acetyltransferase HLLCKODE_01795 904306.HMPREF9192_1468 4e-278 963.4 Bacilli cls ko:K06131,ko:K06915 ko00564,ko01100,map00564,map01100 R07390 RC00017 ko00000,ko00001,ko01000 Bacteria 1TPKY@1239,4H9TI@91061,COG1502@1,COG1502@2 NA|NA|NA I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol HLLCKODE_01796 888833.HMPREF9421_1151 1.8e-279 968.0 Bacilli opuD GO:0003674,GO:0005215,GO:0006810,GO:0006811,GO:0006812,GO:0006950,GO:0006970,GO:0008150,GO:0008324,GO:0008519,GO:0009266,GO:0009409,GO:0009628,GO:0015075,GO:0015101,GO:0015199,GO:0015651,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0022857,GO:0031460,GO:0034220,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0072337,GO:0072349,GO:0072488,GO:0098655 ko:K05020 ko00000,ko02000 2.A.15.1.1,2.A.15.1.11 Bacteria 1TRS6@1239,4HA7U@91061,COG1292@1,COG1292@2 NA|NA|NA M Belongs to the BCCT transporter (TC 2.A.15) family HLLCKODE_01797 1095726.HMPREF1116_0263 3.4e-36 157.5 Bacteria ko:K10716 ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 Bacteria COG1226@1,COG1226@2 NA|NA|NA P (belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family) HLLCKODE_01798 888833.HMPREF9421_1153 4.6e-45 186.8 Bacteria Bacteria COG5655@1,COG5655@2 NA|NA|NA L RePlication protein HLLCKODE_01799 1046629.Ssal_00877 0.0 1175.6 Bacilli uvrC GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 ko:K03703 ko03420,map03420 ko00000,ko00001,ko03400 Bacteria 1TP4B@1239,4H9QH@91061,COG0322@1,COG0322@2 NA|NA|NA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision HLLCKODE_01800 322159.STER_1281 5.5e-124 450.3 Bacilli yjjG GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006206,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008655,GO:0009058,GO:0009112,GO:0009410,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019856,GO:0019859,GO:0030145,GO:0034641,GO:0034654,GO:0042221,GO:0042578,GO:0043094,GO:0043100,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046112,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 3.1.3.102,3.1.3.104,3.1.3.5,3.8.1.2 ko:K01560,ko:K07025,ko:K08723,ko:K20862 ko00230,ko00240,ko00361,ko00625,ko00740,ko00760,ko01100,ko01110,ko01120,map00230,map00240,map00361,map00625,map00740,map00760,map01100,map01110,map01120 M00125 R00183,R00511,R00548,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346,R05287,R07280 RC00017,RC00697 ko00000,ko00001,ko00002,ko01000 iECNA114_1301.ECNA114_4614 Bacteria 1TWM7@1239,4HEXU@91061,COG1011@1,COG1011@2 NA|NA|NA E hydrolase HLLCKODE_01801 904306.HMPREF9192_1464 3e-119 434.5 Bacilli sdaAB 4.3.1.17 ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 R00220,R00590 RC00331,RC02600 ko00000,ko00001,ko01000 Bacteria 1U8TZ@1239,4HBD6@91061,COG1760@1,COG1760@2 NA|NA|NA E L-serine dehydratase HLLCKODE_01802 1046629.Ssal_00873 2e-147 528.5 Bacilli sdaAA 4.3.1.17 ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 R00220,R00590 RC00331,RC02600 ko00000,ko00001,ko01000 Bacteria 1TP79@1239,4HAI1@91061,COG1760@1,COG1760@2 NA|NA|NA E L-serine dehydratase HLLCKODE_01803 1046629.Ssal_00871 0.0 2278.1 Firmicutes fruA 3.2.1.1,3.2.1.26,3.2.1.65,3.2.1.80 ko:K01176,ko:K01193,ko:K01212,ko:K03332 ko00051,ko00052,ko00500,ko01100,ko04973,map00051,map00052,map00500,map01100,map04973 R00801,R00802,R00879,R02108,R02112,R02410,R03635,R03921,R05624,R06088,R11262,R11311 RC00028,RC00077,RC03278 ko00000,ko00001,ko01000 GH13,GH32 Bacteria 1TS4M@1239,COG1621@1,COG1621@2,COG3583@1,COG3583@2,COG5492@1,COG5492@2 NA|NA|NA G Belongs to the glycosyl hydrolase 32 family HLLCKODE_01804 435842.HMPREF0848_01912 1.9e-133 481.9 Bacilli Bacteria 1TRSF@1239,4HCMP@91061,COG2826@1,COG2826@2 NA|NA|NA L Integrase HLLCKODE_01805 1321784.HMPREF1987_01320 2e-202 712.2 Peptostreptococcaceae Bacteria 1UW19@1239,25Q0Y@186801,25U68@186804,COG1479@1,COG1479@2 NA|NA|NA S Protein of unknown function DUF262 HLLCKODE_01806 411465.PEPMIC_00441 2.7e-151 542.0 Clostridia Bacteria 1UYG3@1239,24F1Q@186801,COG1479@1,COG1479@2 NA|NA|NA S Protein of unknown function DUF262 HLLCKODE_01807 1114965.Spaf_0904 3.8e-78 297.4 Bacilli mutT 3.6.1.55 ko:K03574 ko00000,ko01000,ko03400 Bacteria 1VD3G@1239,4IPPD@91061,COG1051@1,COG1051@2 NA|NA|NA F COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes HLLCKODE_01808 888048.HMPREF8577_0354 4e-79 300.8 Bacilli 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 ko00000,ko00001,ko01000,ko01002 Bacteria 1V7WG@1239,4HK3X@91061,COG1714@1,COG1714@2 NA|NA|NA S RDD family HLLCKODE_01809 1046629.Ssal_00866 4.2e-164 583.9 Bacteria ko:K20342,ko:K20480 ko02024,map02024 ko00000,ko00001,ko03000 Bacteria COG1396@1,COG1396@2 NA|NA|NA K sequence-specific DNA binding HLLCKODE_01810 1046629.Ssal_00865 8.9e-153 546.2 Bacilli ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TRNT@1239,4HB3P@91061,COG1131@1,COG1131@2 NA|NA|NA V ABC transporter, ATP-binding protein HLLCKODE_01811 1046629.Ssal_00863 1.7e-96 359.0 Bacilli ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1VBHE@1239,2DN7R@1,32W08@2,4HMWG@91061 NA|NA|NA S ABC-2 family transporter protein HLLCKODE_01812 1046629.Ssal_00862 1.1e-151 542.7 Bacteria ko:K20342,ko:K20480 ko02024,map02024 ko00000,ko00001,ko03000 Bacteria COG1396@1,COG1396@2 NA|NA|NA K sequence-specific DNA binding HLLCKODE_01813 873449.STRCR_1470 1e-50 206.5 Bacilli ywrO ko:K11748 ko00000,ko02000 2.A.37.1.2 Bacteria 1V4UF@1239,4HH6R@91061,COG2249@1,COG2249@2 NA|NA|NA S general stress protein HLLCKODE_01814 1046629.Ssal_00534 8.4e-142 509.6 Bacilli Bacteria 1TQP6@1239,4HDSE@91061,COG3547@1,COG3547@2 NA|NA|NA L PFAM transposase IS116 IS110 IS902 family HLLCKODE_01815 1046629.Ssal_02147 7.2e-65 253.1 Bacteria Bacteria COG3547@1,COG3547@2 NA|NA|NA L Transposase (IS116 IS110 IS902 family) HLLCKODE_01816 663952.SDD27957_05960 2.6e-09 68.6 Streptococcus dysgalactiae group Bacteria 1M9M6@119603,1TXBA@1239,2DJ70@1,304WJ@2,4I68X@91061 NA|NA|NA HLLCKODE_01818 1046629.Ssal_00979 8.4e-166 589.7 Firmicutes yeiH Bacteria 1TQYA@1239,COG2855@1,COG2855@2 NA|NA|NA S Membrane HLLCKODE_01819 1046629.Ssal_00980 1.3e-123 449.1 Bacilli mur1 3.4.17.14,3.5.1.28 ko:K01448,ko:K02395,ko:K07260 ko00550,ko01100,ko01502,ko01503,ko02020,map00550,map01100,map01502,map01503,map02020 M00651,M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504,ko02035,ko03036 Bacteria 1UYRM@1239,4HAU6@91061,COG1705@1,COG1705@2 NA|NA|NA NU muramidase HLLCKODE_01820 1046629.Ssal_00982 7.6e-166 589.7 Bacilli cpsY Bacteria 1TP3E@1239,4HC5J@91061,COG0583@1,COG0583@2 NA|NA|NA K Transcriptional regulator HLLCKODE_01821 1046629.Ssal_00983 0.0 1160.2 Bacilli glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 iNJ661.Rv3436c,iSB619.SA_RS11245,iYO844.BSU01780 Bacteria 1TPGU@1239,4H9R4@91061,COG0449@1,COG0449@2 NA|NA|NA M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source HLLCKODE_01822 1046629.Ssal_00985 6.6e-59 233.0 Bacilli phnA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K06193 ko01120,map01120 ko00000 Bacteria 1V6NA@1239,4HIKN@91061,COG2824@1,COG2824@2 NA|NA|NA P Alkylphosphonate utilization operon protein PhnA HLLCKODE_01823 264199.stu0875 3.1e-105 387.9 Bacilli artQ ko:K02029,ko:K02030,ko:K17073,ko:K17074 ko02010,map02010 M00236,M00589 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.20 Bacteria 1V280@1239,4HGMH@91061,COG0765@1,COG0765@2 NA|NA|NA P ABC transporter (Permease HLLCKODE_01824 1046629.Ssal_00987 2e-112 411.8 Bacilli glnQ 3.6.3.21 ko:K02028 M00236 ko00000,ko00002,ko01000,ko02000 3.A.1.3 Bacteria 1UYAZ@1239,4HE6M@91061,COG1126@1,COG1126@2 NA|NA|NA E abc transporter atp-binding protein HLLCKODE_01825 1046629.Ssal_00988 6.7e-156 556.6 Firmicutes aatB ko:K02029,ko:K02030 M00236 ko00000,ko00002,ko02000 3.A.1.3 Bacteria 1TQNR@1239,COG0834@1,COG0834@2 NA|NA|NA ET ABC transporter substrate-binding protein HLLCKODE_01826 904306.HMPREF9192_1830 2.6e-266 924.1 Bacilli uvrX 2.7.7.7 ko:K02346,ko:K03502,ko:K14161 ko00000,ko01000,ko03400 Bacteria 1TP42@1239,4HA1P@91061,COG0389@1,COG0389@2 NA|NA|NA L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII HLLCKODE_01827 435842.HMPREF0848_00770 1.2e-48 199.1 Bacilli Bacteria 1VFMU@1239,2E59Z@1,33028@2,4HQG9@91061 NA|NA|NA HLLCKODE_01828 1046629.Ssal_00990 1.3e-44 185.3 Firmicutes Bacteria 1VFJD@1239,2E660@1,330UP@2 NA|NA|NA HLLCKODE_01829 904306.HMPREF9192_1827 4.6e-188 663.7 Bacilli adhP GO:0003674,GO:0003824,GO:0004022,GO:0005488,GO:0006081,GO:0006117,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009636,GO:0009987,GO:0010033,GO:0016491,GO:0016614,GO:0016616,GO:0033554,GO:0042221,GO:0042493,GO:0043167,GO:0043169,GO:0044237,GO:0044248,GO:0045471,GO:0046185,GO:0046187,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0097305,GO:1901575,GO:1901700 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 iECP_1309.ECP_1480 Bacteria 1TP5B@1239,4HA9Z@91061,COG1064@1,COG1064@2 NA|NA|NA C alcohol dehydrogenase HLLCKODE_01830 1046629.Ssal_00994 6.7e-99 366.7 Bacilli rimL ko:K03817 ko00000,ko01000,ko03009 Bacteria 1V3NE@1239,4HG1N@91061,COG1670@1,COG1670@2 NA|NA|NA J COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins HLLCKODE_01831 904306.HMPREF9192_1826 1.9e-302 1044.3 Bacilli guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.3.1.128,6.3.5.2 ko:K01951,ko:K03790 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002,ko03009 iJN746.PP_1032,iLJ478.TM1820,iSF_1195.SF2553,iSFxv_1172.SFxv_2808,iS_1188.S2725,iYL1228.KPN_02833 Bacteria 1TPG8@1239,4HA7Q@91061,COG0518@1,COG0518@2,COG0519@1,COG0519@2 NA|NA|NA F Catalyzes the synthesis of GMP from XMP HLLCKODE_01832 435842.HMPREF0848_00766 3.5e-126 457.6 Bacilli gntR1 ko:K03710,ko:K11922 ko00000,ko03000 Bacteria 1UYBW@1239,4HDDG@91061,COG2188@1,COG2188@2 NA|NA|NA K transcriptional HLLCKODE_01833 435842.HMPREF0848_00765 2e-55 221.5 Bacilli ylxM GO:0003674,GO:0008150,GO:0030234,GO:0030695,GO:0050790,GO:0060589,GO:0065007,GO:0065009,GO:0098772 ko:K09787 ko00000 Bacteria 1VEGP@1239,4HKK6@91061,COG2739@1,COG2739@2 NA|NA|NA S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein HLLCKODE_01834 1046629.Ssal_01006 2.9e-274 950.7 Bacilli ffh GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 Bacteria 1TP06@1239,4H9T4@91061,COG0541@1,COG0541@2 NA|NA|NA U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HLLCKODE_01835 435842.HMPREF0848_00763 2e-86 325.1 Firmicutes ko:K16788 ko00000,ko02000 2.A.88.5 Bacteria 1VDRR@1239,2A1RE@1,32VI2@2 NA|NA|NA HLLCKODE_01836 435842.HMPREF0848_00762 7e-92 343.2 Bacilli niaR ko:K07105 ko00000 Bacteria 1V6EY@1239,4HGYB@91061,COG1827@1,COG1827@2 NA|NA|NA S small molecule binding protein (contains 3H domain) HLLCKODE_01837 435842.HMPREF0848_00761 1.6e-128 465.3 Bacilli Bacteria 1V758@1239,4HIKZ@91061,COG1396@1,COG1396@2,COG2932@1,COG2932@2 NA|NA|NA K DNA-binding helix-turn-helix protein HLLCKODE_01838 435842.HMPREF0848_00760 6.1e-157 560.1 Bacilli ylqF GO:0003674,GO:0003824,GO:0003924,GO:0008150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022613,GO:0042254,GO:0044085,GO:0071840 ko:K14540 ko00000,ko03009 Bacteria 1TQGK@1239,4HA4D@91061,COG1161@1,COG1161@2 NA|NA|NA S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity HLLCKODE_01839 435842.HMPREF0848_00759 3.4e-135 487.6 Bacilli rnhB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03470 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Bacteria 1V1D6@1239,4HB7M@91061,COG0164@1,COG0164@2 NA|NA|NA L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids HLLCKODE_01840 435842.HMPREF0848_00758 9.4e-156 556.2 Firmicutes Bacteria 1TRQ7@1239,COG1940@1,COG1940@2 NA|NA|NA GK ROK family HLLCKODE_01841 435842.HMPREF0848_00757 2.1e-154 551.6 Bacilli dprA GO:0007154,GO:0008150,GO:0009292,GO:0009294,GO:0009605,GO:0009987,GO:0009991,GO:0030420,GO:0031668,GO:0044764,GO:0050896,GO:0051704,GO:0051716,GO:0071496 ko:K04096 ko00000 Bacteria 1TPP7@1239,4HGWM@91061,COG0758@1,COG0758@2 NA|NA|NA LU DNA protecting protein DprA HLLCKODE_01842 1046629.Ssal_01017 0.0 1325.1 Bacilli topA 5.99.1.2 ko:K03168 ko00000,ko01000,ko03032,ko03400 Bacteria 1TPUS@1239,4HA6C@91061,COG0550@1,COG0550@2 NA|NA|NA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone HLLCKODE_01843 435842.HMPREF0848_00755 5.3e-150 537.0 Bacilli Bacteria 1V2FW@1239,2DC01@1,2ZC51@2,4HG69@91061 NA|NA|NA S TraX protein HLLCKODE_01844 904306.HMPREF9192_1813 2.3e-119 434.9 Bacilli Bacteria 1TQ0D@1239,4HDA9@91061,COG0745@1,COG0745@2 NA|NA|NA KT Transcriptional regulatory protein, C terminal HLLCKODE_01845 435842.HMPREF0848_00753 3.1e-235 820.8 Bacilli Bacteria 1TS1G@1239,4HEC4@91061,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor HLLCKODE_01846 1046629.Ssal_01021 1.2e-255 888.6 Bacilli trmFO GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 ko:K04094 ko00000,ko01000,ko03016,ko03036 Bacteria 1TP67@1239,4HB27@91061,COG1206@1,COG1206@2 NA|NA|NA J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs HLLCKODE_01847 1046629.Ssal_01022 8.8e-220 769.2 Bacilli XK27_05470 Bacteria 1TPDQ@1239,4HADW@91061,COG0620@1,COG0620@2 NA|NA|NA E Methionine synthase HLLCKODE_01848 264199.stu0906 1e-72 279.3 Firmicutes ndk GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 Bacteria 1V44G@1239,COG0105@1,COG0105@2 NA|NA|NA F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate HLLCKODE_01849 904306.HMPREF9192_1808 1.1e-44 185.7 Firmicutes pspE ko:K03972 ko00000 Bacteria 1U0PW@1239,COG0607@1,COG0607@2 NA|NA|NA P Rhodanese-like protein HLLCKODE_01850 435842.HMPREF0848_00749 2.4e-136 491.5 Bacilli Bacteria 1TRQC@1239,4HD7P@91061,COG1028@1,COG1028@2 NA|NA|NA IQ Acetoin reductase HLLCKODE_01852 1046629.Ssal_01034 0.0 1175.6 Bacilli lepA ko:K03596 ko05134,map05134 ko00000,ko00001 Bacteria 1TP0G@1239,4HASA@91061,COG0481@1,COG0481@2 NA|NA|NA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner HLLCKODE_01855 1046629.Ssal_01037 0.0 1087.0 Bacilli alsS 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQE8@1239,4HAV1@91061,COG0028@1,COG0028@2 NA|NA|NA EH Belongs to the TPP enzyme family HLLCKODE_01856 435842.HMPREF0848_00743 3.1e-130 471.1 Bacilli budA GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0047605 4.1.1.5 ko:K01575 ko00650,ko00660,map00650,map00660 R02948 RC00812 ko00000,ko00001,ko01000 Bacteria 1V4AH@1239,4HJ98@91061,COG3527@1,COG3527@2 NA|NA|NA H Belongs to the alpha-acetolactate decarboxylase family HLLCKODE_01857 904306.HMPREF9192_1799 3.2e-64 251.1 Bacilli mgrA ko:K06075 ko00000,ko03000 Bacteria 1VDJQ@1239,4HN0M@91061,COG1846@1,COG1846@2 NA|NA|NA K Transcriptional regulator, MarR family HLLCKODE_01858 1282665.H353_03793 4.6e-124 450.7 Bacilli Bacteria 1UY32@1239,4HMCD@91061,COG4922@1,COG4922@2 NA|NA|NA S SnoaL-like domain HLLCKODE_01859 435842.HMPREF0848_00741 1.6e-150 538.9 Bacilli Bacteria 1V55H@1239,4HD0S@91061,COG0604@1,COG0604@2 NA|NA|NA C alcohol dehydrogenase HLLCKODE_01860 888833.HMPREF9421_1656 2.8e-126 458.0 Bacilli proV ko:K05847 ko02010,map02010 M00209 ko00000,ko00001,ko00002,ko02000 3.A.1.12 Bacteria 1TPV8@1239,4H9SI@91061,COG1125@1,COG1125@2 NA|NA|NA E abc transporter atp-binding protein HLLCKODE_01861 888833.HMPREF9421_1655 1.2e-261 908.7 Bacilli proWX ko:K05845,ko:K05846 ko02010,map02010 M00209 ko00000,ko00001,ko00002,ko02000 3.A.1.12 Bacteria 1TQ7D@1239,4HBDR@91061,COG1174@1,COG1174@2,COG1732@1,COG1732@2 NA|NA|NA P ABC transporter HLLCKODE_01862 435842.HMPREF0848_00738 5.3e-139 500.4 Bacilli Bacteria 1TPPX@1239,4HDAC@91061,COG0384@1,COG0384@2 NA|NA|NA S Phenazine biosynthesis protein HLLCKODE_01863 1114965.Spaf_1763 9.1e-91 339.7 Firmicutes 2.7.7.65 ko:K16923,ko:K18967 M00582 ko00000,ko00002,ko01000,ko02000 3.A.1.28,9.B.34.1.1 Bacteria 1V65C@1239,COG3275@1,COG3275@2 NA|NA|NA T Psort location CytoplasmicMembrane, score HLLCKODE_01864 888048.HMPREF8577_1226 3.7e-132 477.6 Bacilli cbiQ ko:K02008,ko:K16785 ko02010,map02010 M00245,M00246,M00582 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23,3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 Bacteria 1UYQQ@1239,4HFDP@91061,COG0619@1,COG0619@2 NA|NA|NA P cobalt transport HLLCKODE_01865 435842.HMPREF0848_00735 4.5e-157 560.5 Bacteria ko:K16786,ko:K16787 ko02010,map02010 M00582 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 Bacteria COG1122@1,COG1122@2 NA|NA|NA P ATPase activity HLLCKODE_01866 435842.HMPREF0848_00734 1.8e-150 538.5 Bacilli cbiO2 ko:K16786,ko:K16787 ko02010,map02010 M00582 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 Bacteria 1VSUE@1239,4HT6W@91061,COG1122@1,COG1122@2 NA|NA|NA P ABC transporter, ATP-binding protein HLLCKODE_01867 999425.HMPREF9186_00918 2.9e-63 247.7 Bacilli pnuC ko:K03811 ko00000,ko02000 4.B.1.1 Bacteria 1UYDN@1239,4HJE5@91061,COG3201@1,COG3201@2 NA|NA|NA H nicotinamide mononucleotide transporter HLLCKODE_01868 999425.HMPREF9186_00916 2.5e-66 258.1 Bacilli Bacteria 1V53C@1239,4HN6G@91061,COG1959@1,COG1959@2 NA|NA|NA K Transcriptional regulator HLLCKODE_01869 999425.HMPREF9186_00915 1.5e-176 625.5 Bacilli 1.1.1.1 ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 Bacteria 1TQ0M@1239,4HA8M@91061,COG0604@1,COG0604@2 NA|NA|NA C nadph quinone reductase HLLCKODE_01870 889204.HMPREF9423_1742 8.9e-153 546.2 Streptococcus infantis Bacteria 1UWGW@1239,43GIA@68892,4IDYE@91061,COG2267@1,COG2267@2 NA|NA|NA I Alpha/beta hydrolase family HLLCKODE_01871 999425.HMPREF9186_00913 2.1e-152 545.0 Bacilli Bacteria 1TRQB@1239,4HAY3@91061,COG1028@1,COG1028@2 NA|NA|NA IQ Belongs to the short-chain dehydrogenases reductases (SDR) family HLLCKODE_01872 888048.HMPREF8577_1221 8.1e-41 172.9 Bacilli Bacteria 1W4NX@1239,2DD3F@1,2ZGBB@2,4I0KR@91061 NA|NA|NA HLLCKODE_01873 888048.HMPREF8577_1220 3.7e-55 221.1 Firmicutes Bacteria 1VA8B@1239,2BS9S@1,32XMN@2 NA|NA|NA S Protein of unknown function with HXXEE motif HLLCKODE_01874 999425.HMPREF9186_00911 5.1e-99 367.1 Bacilli Bacteria 1TSUJ@1239,4IPZN@91061,COG1309@1,COG1309@2 NA|NA|NA K Transcriptional regulator, TetR family HLLCKODE_01875 264199.stu0932 5e-154 550.4 Bacilli czcD ko:K16264 ko00000,ko02000 2.A.4.1 Bacteria 1TR92@1239,4HBCQ@91061,COG1230@1,COG1230@2 NA|NA|NA P cation diffusion facilitator family transporter HLLCKODE_01876 999425.HMPREF9186_00908 6.7e-193 679.9 Bacilli hemH GO:0003674,GO:0003824,GO:0004325,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPKF@1239,4HAYG@91061,COG0276@1,COG0276@2 NA|NA|NA H Catalyzes the ferrous insertion into protoporphyrin IX HLLCKODE_01877 904306.HMPREF9192_1783 2.3e-187 661.4 Bacilli adhB 1.1.1.1,1.1.1.14 ko:K00001,ko:K00008 ko00010,ko00040,ko00051,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00040,map00051,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 M00014 R00623,R00754,R00875,R01896,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00085,RC00087,RC00088,RC00099,RC00102,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPIW@1239,4HB2G@91061,COG1063@1,COG1063@2 NA|NA|NA E Dehydrogenase HLLCKODE_01878 1114965.Spaf_1743 1.3e-135 489.2 Firmicutes Bacteria 1V01B@1239,COG4814@1,COG4814@2 NA|NA|NA G protein with an alpha beta hydrolase fold HLLCKODE_01881 1046629.Ssal_01067 3.5e-109 401.0 Bacilli gph 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 R01334 RC00017 ko00000,ko00001,ko01000 Bacteria 1TPPZ@1239,4IPIP@91061,COG0546@1,COG0546@2 NA|NA|NA S HAD hydrolase, family IA, variant 1 HLLCKODE_01882 435842.HMPREF0848_00708 0.0 1411.0 Bacilli Bacteria 1TRA8@1239,4HCIF@91061,COG1061@1,COG1061@2 NA|NA|NA V Type III restriction enzyme, res subunit HLLCKODE_01883 1046629.Ssal_01069 2.1e-49 201.4 Bacilli Bacteria 1V09B@1239,4HSNZ@91061,COG2304@1,COG2304@2 NA|NA|NA S von Willebrand factor (vWF) type A domain HLLCKODE_01884 1046629.Ssal_01070 2.1e-174 618.2 Bacilli yclQ ko:K02016 ko02010,map02010 M00240 ko00000,ko00001,ko00002,ko02000 3.A.1.14 Bacteria 1UXCZ@1239,4HAMP@91061,COG4607@1,COG4607@2 NA|NA|NA P ABC-type enterochelin transport system, periplasmic component HLLCKODE_01885 1046629.Ssal_01071 3.7e-233 813.9 Bacilli dinF Bacteria 1TNZN@1239,4HANM@91061,COG0534@1,COG0534@2 NA|NA|NA V Mate efflux family protein HLLCKODE_01886 1046629.Ssal_01073 6.2e-277 959.5 Bacilli Bacteria 1UK4X@1239,2DM53@1,31R8Y@2,4IU8I@91061 NA|NA|NA S Psort location CytoplasmicMembrane, score HLLCKODE_01887 1046629.Ssal_01074 2.8e-307 1060.4 Bacilli FbpA ko:K12341 ko03070,map03070 ko00000,ko00001,ko02044 1.B.40.1.1 Bacteria 1TQ8A@1239,4H9UF@91061,COG1293@1,COG1293@2 NA|NA|NA K RNA-binding protein homologous to eukaryotic snRNP HLLCKODE_01888 904306.HMPREF9192_1767 1.4e-134 485.7 Bacilli Bacteria 1V7WE@1239,2B4EH@1,31X62@2,4HJ8G@91061 NA|NA|NA S TraX protein HLLCKODE_01889 904306.HMPREF9192_1766 2e-92 345.1 Bacilli thiJ 2.7.11.1,3.5.1.124 ko:K03152,ko:K05520,ko:K12132 ko00000,ko01000,ko01001,ko01002 Bacteria 1V3WB@1239,4HM36@91061,COG0693@1,COG0693@2 NA|NA|NA S DJ-1 family HLLCKODE_01890 435842.HMPREF0848_00695 1.5e-144 518.8 Bacilli pyrK GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0016645,GO:0016646,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042602,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0052875,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 ko:K02823 ko00240,ko01100,map00240,map01100 ko00000,ko00001 iYO844.BSU15530 Bacteria 1TQ5D@1239,4HAU4@91061,COG0543@1,COG0543@2 NA|NA|NA C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) HLLCKODE_01891 435842.HMPREF0848_00694 9.4e-175 619.4 Bacilli pyrD GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.98.1 ko:K00226,ko:K02823,ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01867,R01869 RC00051 ko00000,ko00001,ko00002,ko01000 iYO844.BSU15540 Bacteria 1TPFV@1239,4HA5H@91061,COG0167@1,COG0167@2 NA|NA|NA F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily HLLCKODE_01892 322159.STER_0970 2.7e-163 581.3 Firmicutes cas1 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 ko:K15342 ko00000,ko02048,ko03400 Bacteria 1TQWG@1239,COG1518@1,COG1518@2 NA|NA|NA L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette HLLCKODE_01893 264199.stu0958 1.6e-52 211.8 Firmicutes cas2 ko:K09951 ko00000,ko02048 Bacteria 1VFRC@1239,COG1343@1,COG1343@2 NA|NA|NA L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette HLLCKODE_01894 264199.stu0959 4.1e-130 470.7 Bacilli cas6 ko:K19091 ko00000,ko01000,ko02048 Bacteria 1V7VJ@1239,4HZ1B@91061,COG5551@1,COG5551@2 NA|NA|NA S Pfam:DUF2276 HLLCKODE_01895 264199.stu0960 0.0 1398.3 Bacilli csm1 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K07016 ko00000,ko02048 Bacteria 1TRW5@1239,4HM8F@91061,COG1353@1,COG1353@2 NA|NA|NA S CRISPR-associated protein Csm1 family HLLCKODE_01896 322159.STER_0974 2e-38 165.2 Bacteria csm2 ko:K19138 ko00000,ko02048 Bacteria COG1421@1,COG1421@2 NA|NA|NA L Csm2 Type III-A HLLCKODE_01897 322159.STER_0975 1.4e-113 415.6 Bacilli csm3 ko:K09002 ko00000,ko02048 Bacteria 1V3DM@1239,4HPB8@91061,COG1337@1,COG1337@2 NA|NA|NA L RAMP superfamily HLLCKODE_01898 264199.stu0963 2.3e-162 578.2 Firmicutes csm4 ko:K19139 ko00000,ko02048 Bacteria 1V4UZ@1239,COG1567@1,COG1567@2 NA|NA|NA L CRISPR-associated RAMP protein, Csm4 family HLLCKODE_01899 322159.STER_0977 1.3e-204 718.8 Firmicutes csm5 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K19140 ko00000,ko02048 Bacteria 1V8JA@1239,COG1332@1,COG1332@2 NA|NA|NA L CRISPR-associated RAMP protein, Csm5 family HLLCKODE_01900 889204.HMPREF9423_0555 6.8e-111 407.5 Firmicutes csm6 Bacteria 1TRJ6@1239,28K2E@1,2Z9RR@2 NA|NA|NA S Psort location Cytoplasmic, score HLLCKODE_01901 889204.HMPREF9423_0556 4.5e-148 531.2 Firmicutes csm6 Bacteria 1TRJ6@1239,28K2E@1,2Z9RR@2 NA|NA|NA S Psort location Cytoplasmic, score HLLCKODE_01902 435842.HMPREF0848_00693 8.5e-125 453.0 Bacilli pyrF GO:0003674,GO:0003824,GO:0004590,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 iECO103_1326.ECO103_1444,iECSF_1327.ECSF_1264,iSFV_1184.SFV_1294,iSF_1195.SF1285,iSFxv_1172.SFxv_1457,iS_1188.S1368,ic_1306.c1750 Bacteria 1TPPH@1239,4HAJ2@91061,COG0284@1,COG0284@2 NA|NA|NA F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) HLLCKODE_01903 1046629.Ssal_01081 4.4e-112 410.6 Bacilli pyrE 2.4.2.10,4.1.1.23 ko:K00762,ko:K01591,ko:K13421 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00051 R00965,R01870,R08231 RC00063,RC00409,RC00611 ko00000,ko00001,ko00002,ko01000 iYO844.BSU15560 Bacteria 1V1BZ@1239,4HFV7@91061,COG0461@1,COG0461@2 NA|NA|NA F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) HLLCKODE_01904 435842.HMPREF0848_00691 1.1e-243 849.0 Bacilli nylA 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 Bacteria 1TPGJ@1239,4HBE7@91061,COG0154@1,COG0154@2 NA|NA|NA J Belongs to the amidase family HLLCKODE_01905 435842.HMPREF0848_00690 4.6e-149 533.9 Bacilli yckB ko:K02030,ko:K02424 ko02010,map02010 M00234,M00236 ko00000,ko00001,ko00002,ko02000,ko02035 3.A.1.3,3.A.1.3.10,3.A.1.3.14 Bacteria 1UHHG@1239,4H9NX@91061,COG0834@1,COG0834@2 NA|NA|NA ET Belongs to the bacterial solute-binding protein 3 family HLLCKODE_01906 699248.SRA_05851 9.3e-81 306.6 Bacilli yecS GO:0000099,GO:0000101,GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006791,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015179,GO:0015184,GO:0015318,GO:0015711,GO:0015804,GO:0015807,GO:0015811,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0072348,GO:0072349,GO:0098656,GO:1901682,GO:1902475,GO:1903825,GO:1905039 ko:K10009 ko02010,map02010 M00234 ko00000,ko00001,ko00002,ko02000 3.A.1.3.10,3.A.1.3.14 iJN746.PP_0226 Bacteria 1TQ43@1239,4HCZV@91061,COG0765@1,COG0765@2 NA|NA|NA P ABC transporter (Permease HLLCKODE_01907 1046629.Ssal_01083 0.0 1185.6 Bacilli sasH 3.1.3.5,3.6.1.45 ko:K11751 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 Bacteria 1TPV2@1239,4H9VJ@91061,COG0737@1,COG0737@2 NA|NA|NA F Belongs to the 5'-nucleotidase family HLLCKODE_01908 904306.HMPREF9192_1758 4.6e-169 600.5 Bacilli bglC Bacteria 1UZG6@1239,4HCQS@91061,COG2207@1,COG2207@2 NA|NA|NA K Transcriptional regulator HLLCKODE_01909 904306.HMPREF9192_1757 1.8e-243 848.2 Bacilli mnmE GO:0003674,GO:0005488,GO:0005515,GO:0042802 ko:K03650 R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 Bacteria 1TPJF@1239,4HA06@91061,COG0486@1,COG0486@2 NA|NA|NA S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 HLLCKODE_01910 1046629.Ssal_01087 2.2e-238 831.2 Bacilli agcS GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03310 ko00000 2.A.25 Bacteria 1TNZP@1239,4H9SZ@91061,COG1115@1,COG1115@2 NA|NA|NA E (Alanine) symporter HLLCKODE_01911 1046629.Ssal_01088 0.0 1473.8 Bacilli pcrA 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 1TPSU@1239,4HB12@91061,COG0210@1,COG0210@2 NA|NA|NA L ATP-dependent DNA helicase HLLCKODE_01912 322159.STER_0995 4.3e-239 833.6 Bacilli metY 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 Bacteria 1VYCY@1239,4H9X5@91061,COG2873@1,COG2873@2 NA|NA|NA E o-acetylhomoserine HLLCKODE_01913 904306.HMPREF9192_1752 1.8e-136 491.9 Bacilli Bacteria 1TQTU@1239,4HEHK@91061,COG0561@1,COG0561@2 NA|NA|NA S haloacid dehalogenase-like hydrolase HLLCKODE_01914 1046629.Ssal_01091 6.5e-87 326.6 Bacilli tpx GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009405,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0015036,GO:0016209,GO:0016491,GO:0016667,GO:0016671,GO:0016684,GO:0019725,GO:0020012,GO:0030312,GO:0030682,GO:0032843,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0051920,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071944,GO:0075136,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 ko:K11065 ko00000,ko01000 Bacteria 1V474@1239,4HFMW@91061,COG2077@1,COG2077@2 NA|NA|NA O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides HLLCKODE_01915 904306.HMPREF9192_1749 2.1e-111 408.3 Bacilli hsdS2 2.1.1.72 ko:K03427 ko00000,ko01000,ko02048 Bacteria 1VQES@1239,4HE4K@91061,COG0732@1,COG0732@2 NA|NA|NA V Type I restriction modification DNA specificity domain HLLCKODE_01916 435842.HMPREF0848_00681 8e-35 152.5 Bacteria M1-755 ko:K09155 ko00000 Bacteria COG2461@1,COG2461@2 NA|NA|NA P Hemerythrin HHE cation binding domain protein HLLCKODE_01917 1046629.Ssal_01094 1e-235 822.4 Bacilli XK27_04775 ko:K09155 ko00000 Bacteria 1TRD5@1239,4HAAW@91061,COG2461@1,COG2461@2 NA|NA|NA S hemerythrin HHE cation binding domain HLLCKODE_01918 904306.HMPREF9192_1746 1.2e-144 519.2 Bacilli truB GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 ko:K03177,ko:K03483 ko00000,ko01000,ko03000,ko03016 iSB619.SA_RS06305 Bacteria 1TP9Y@1239,4HA9X@91061,COG0130@1,COG0130@2 NA|NA|NA J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs HLLCKODE_01919 1046629.Ssal_01096 1.1e-172 612.5 Bacilli ribF 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS06310 Bacteria 1TPKS@1239,4H9KE@91061,COG0196@1,COG0196@2 NA|NA|NA H Belongs to the ribF family HLLCKODE_01920 904306.HMPREF9192_1744 7.9e-70 269.6 Bacilli spxA 1.20.4.1 ko:K00537,ko:K16509 ko00000,ko01000 Bacteria 1V3QC@1239,4HH0I@91061,COG1393@1,COG1393@2 NA|NA|NA K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress HLLCKODE_01921 1046629.Ssal_01098 5.1e-44 183.3 Bacilli yktA ko:K16509 ko00000 Bacteria 1VEK8@1239,4HNKR@91061,COG4476@1,COG4476@2 NA|NA|NA S Belongs to the UPF0223 family HLLCKODE_01922 1046629.Ssal_01099 3.2e-141 507.7 Bacilli suhB 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 Bacteria 1TR4E@1239,4HB92@91061,COG0483@1,COG0483@2 NA|NA|NA G Belongs to the inositol monophosphatase superfamily HLLCKODE_01923 1046629.Ssal_01100 9.1e-245 852.4 Bacilli rsmF GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176,2.1.1.178 ko:K03500,ko:K11392 ko00000,ko01000,ko03009 Bacteria 1TPGQ@1239,4HCHQ@91061,COG0144@1,COG0144@2,COG3270@1,COG3270@2 NA|NA|NA J NOL1 NOP2 sun family protein HLLCKODE_01924 904306.HMPREF9192_1740 2.6e-155 554.7 Bacilli pstS GO:0003674,GO:0005488,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015698,GO:0042301,GO:0043167,GO:0043168,GO:0051179,GO:0051234 ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 ko00000,ko00001,ko00002,ko02000 3.A.1.7 Bacteria 1TQ5X@1239,4HBEB@91061,COG0226@1,COG0226@2 NA|NA|NA P phosphate HLLCKODE_01925 904306.HMPREF9192_1739 1.4e-156 558.9 Bacilli pstC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02037 ko02010,map02010 M00222 ko00000,ko00001,ko00002,ko02000 3.A.1.7 Bacteria 1TSPP@1239,4HC9H@91061,COG0573@1,COG0573@2 NA|NA|NA P probably responsible for the translocation of the substrate across the membrane HLLCKODE_01926 904306.HMPREF9192_1738 9.1e-156 556.2 Bacilli pstA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02038 ko02010,map02010 M00222 ko00000,ko00001,ko00002,ko02000 3.A.1.7 Bacteria 1TP74@1239,4HAKF@91061,COG0581@1,COG0581@2 NA|NA|NA P phosphate transport system permease HLLCKODE_01927 1046629.Ssal_01104 1.5e-149 535.4 Bacilli pstB 3.6.3.27 ko:K02036 ko02010,map02010 M00222 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 iLJ478.TM1261 Bacteria 1TP1M@1239,4HAB1@91061,COG1117@1,COG1117@2 NA|NA|NA P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system HLLCKODE_01928 1046629.Ssal_01105 3.9e-139 500.7 Bacilli pstB 3.6.3.27 ko:K02036 ko02010,map02010 M00222 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 iLJ478.TM1261 Bacteria 1TP1M@1239,4HAB1@91061,COG1117@1,COG1117@2 NA|NA|NA P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system HLLCKODE_01929 904306.HMPREF9192_1735 3.2e-113 414.5 Bacilli phoU ko:K02039 ko00000 Bacteria 1URN3@1239,4HEU9@91061,COG0704@1,COG0704@2 NA|NA|NA P Plays a role in the regulation of phosphate uptake HLLCKODE_01930 1046629.Ssal_01107 0.0 1659.4 Bacilli pepN GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.4.11.2 ko:K01256,ko:K08776 ko00480,ko01100,map00480,map01100 R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 Bacteria 1TR43@1239,4HA20@91061,COG0308@1,COG0308@2 NA|NA|NA E aminopeptidase HLLCKODE_01931 1046629.Ssal_01108 1.6e-191 675.2 Bacilli xerS GO:0000150,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009987,GO:0015074,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140097,GO:1901360 Bacteria 1URNQ@1239,4HEPI@91061,COG4974@1,COG4974@2 NA|NA|NA D Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division HLLCKODE_01932 904306.HMPREF9192_1732 3.6e-185 654.1 Bacilli lplA 6.3.1.20 ko:K03800 ko00785,ko01100,map00785,map01100 R07770,R07771,R11143 RC00043,RC00070,RC00090,RC00992,RC02896 ko00000,ko00001,ko01000 Bacteria 1TQ5U@1239,4H9P6@91061,COG0095@1,COG0095@2 NA|NA|NA H Lipoate-protein ligase HLLCKODE_01933 888816.HMPREF9389_1786 2.8e-37 162.9 Streptococcus sanguinis Bacteria 1UA7P@1239,1WRVC@1305,2AQRJ@1,31FZC@2,4IKIV@91061 NA|NA|NA HLLCKODE_01934 1046629.Ssal_01114 0.0 1478.0 Bacilli glgP 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 R02111 ko00000,ko00001,ko01000 GT35 Bacteria 1TQAJ@1239,4H9XI@91061,COG0058@1,COG0058@2 NA|NA|NA G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties HLLCKODE_01935 1046629.Ssal_01115 2.8e-298 1030.4 Bacilli malQ 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 R05196 RC00049 ko00000,ko00001,ko01000 GH77 Bacteria 1W5VQ@1239,4HCHB@91061,COG1640@1,COG1640@2 NA|NA|NA G 4-alpha-glucanotransferase HLLCKODE_01936 1046629.Ssal_01116 4.5e-172 610.5 Bacilli malR ko:K02529 ko00000,ko03000 Bacteria 1TPZM@1239,4H9ZT@91061,COG1609@1,COG1609@2 NA|NA|NA K Transcriptional regulator HLLCKODE_01937 1046629.Ssal_01117 3.9e-229 800.4 Bacilli malX ko:K02027,ko:K15770 ko02010,map02010 M00207,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2 Bacteria 1TPU9@1239,4H9TU@91061,COG2182@1,COG2182@2 NA|NA|NA G ABC transporter HLLCKODE_01938 904306.HMPREF9192_1726 5.7e-250 869.8 Bacilli malF ko:K02025,ko:K02026,ko:K15771 ko02010,map02010 M00207,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2 Bacteria 1TR2A@1239,4HB8H@91061,COG1175@1,COG1175@2 NA|NA|NA P ABC transporter (Permease HLLCKODE_01939 1046629.Ssal_01119 9.8e-152 542.7 Bacilli malG ko:K15772 ko02010,map02010 M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1.16,3.A.1.1.2 Bacteria 1TRB7@1239,4HC5K@91061,COG3833@1,COG3833@2 NA|NA|NA P ABC transporter (Permease HLLCKODE_01940 1046629.Ssal_01120 8.8e-212 742.7 Bacilli msmX ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 ko00000,ko00001,ko00002,ko02000 3.A.1.1 Bacteria 1TP2M@1239,4HAMQ@91061,COG3842@1,COG3842@2 NA|NA|NA P Belongs to the ABC transporter superfamily HLLCKODE_01941 904306.HMPREF9192_1723 1.9e-23 114.4 Bacteria tatA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K03116,ko:K03117 ko03060,ko03070,map03060,map03070 M00336 ko00000,ko00001,ko00002,ko02044 2.A.64 Bacteria COG1826@1,COG1826@2 NA|NA|NA U protein secretion HLLCKODE_01942 904306.HMPREF9192_1722 1.3e-120 439.1 Bacilli tatC GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 ko:K03118 ko03060,ko03070,map03060,map03070 M00336 ko00000,ko00001,ko00002,ko02044 2.A.64 Bacteria 1TTBA@1239,4HAE9@91061,COG0805@1,COG0805@2 NA|NA|NA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes HLLCKODE_01943 904306.HMPREF9192_1721 9.7e-292 1008.8 Bacilli ywbL ko:K07243 ko00000,ko02000 2.A.108.1,2.A.108.2 Bacteria 1TQIA@1239,4HCJZ@91061,COG0672@1,COG0672@2 NA|NA|NA P COG0672 High-affinity Fe2 Pb2 permease HLLCKODE_01944 904306.HMPREF9192_1720 2.2e-229 801.2 Bacilli ycdB ko:K16301 ko00000,ko01000,ko02000 2.A.108.2.3 Bacteria 1UY9Y@1239,4HACQ@91061,COG2837@1,COG2837@2 NA|NA|NA P peroxidase HLLCKODE_01945 322159.STER_1024 1.2e-144 519.2 Bacilli ycdO GO:0000041,GO:0006810,GO:0006811,GO:0006812,GO:0006826,GO:0008150,GO:0015684,GO:0030001,GO:0051179,GO:0051234,GO:0070838,GO:0072511 ko:K07224,ko:K07243 ko00000,ko02000 2.A.108.1,2.A.108.2,2.A.108.2.3 Bacteria 1TS89@1239,4HB0W@91061,COG2822@1,COG2822@2 NA|NA|NA P periplasmic lipoprotein involved in iron transport HLLCKODE_01946 435842.HMPREF0848_00648 0.0 2228.8 Bacilli pulA 3.2.1.1,3.2.1.41 ko:K01176,ko:K01200 ko00500,ko01100,ko01110,ko04973,map00500,map01100,map01110,map04973 R02108,R02111,R02112,R11262 ko00000,ko00001,ko01000 CBM48,GH13 Bacteria 1TP3M@1239,4HBP5@91061,COG1523@1,COG1523@2 NA|NA|NA G belongs to the glycosyl hydrolase 13 family HLLCKODE_01948 1046629.Ssal_01437 1.5e-177 628.6 Bacilli yegQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K08303 ko05120,map05120 ko00000,ko00001,ko01000,ko01002 Bacteria 1TQIZ@1239,4HA2T@91061,COG0826@1,COG0826@2 NA|NA|NA O Peptidase U32 HLLCKODE_01949 904306.HMPREF9192_1140 1.7e-251 874.8 Bacilli yegQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K08303 ko05120,map05120 ko00000,ko00001,ko01000,ko01002 Bacteria 1TPRE@1239,4HBEG@91061,COG0826@1,COG0826@2 NA|NA|NA O Peptidase U32 HLLCKODE_01950 904306.HMPREF9192_1141 1.3e-85 322.4 Bacilli bioY ko:K03523 ko02010,map02010 M00581,M00582 ko00000,ko00001,ko00002,ko02000 2.A.88.1,2.A.88.2 Bacteria 1VA1G@1239,4HNE8@91061,COG1268@1,COG1268@2 NA|NA|NA S biotin synthase HLLCKODE_01952 264199.stu0676 1.1e-33 148.7 Bacilli XK27_12190 Bacteria 1VEFE@1239,4HNSP@91061,COG4443@1,COG4443@2 NA|NA|NA S protein conserved in bacteria HLLCKODE_01953 1046629.Ssal_01431 4.8e-233 813.5 Bacilli mntH GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0042221,GO:0050896,GO:0051716,GO:0070887,GO:0071241,GO:0071248,GO:0071281 ko:K03322 ko00000,ko02000 2.A.55.2.6,2.A.55.3 Bacteria 1TPT1@1239,4HAEA@91061,COG1914@1,COG1914@2 NA|NA|NA P H( )-stimulated, divalent metal cation uptake system HLLCKODE_01954 888821.HMPREF9394_0792 2.8e-11 74.7 Streptococcus sanguinis Bacteria 1UA84@1239,1WRWU@1305,29RMD@1,30CQM@2,4IKJF@91061 NA|NA|NA HLLCKODE_01955 888049.HMPREF8578_1747 1.6e-14 86.3 Streptococcus oralis Bacteria 1TX21@1239,1WQ4M@1303,2ADJV@1,313AA@2,4I5XT@91061 NA|NA|NA HLLCKODE_01956 435842.HMPREF0848_00346 5.4e-286 989.6 Bacilli lysS GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1TP2P@1239,4H9X4@91061,COG1190@1,COG1190@2 NA|NA|NA J Belongs to the class-II aminoacyl-tRNA synthetase family HLLCKODE_01957 1046629.Ssal_01428 2.9e-134 485.3 Bacteria Bacteria COG1388@1,COG1388@2 NA|NA|NA M LysM domain HLLCKODE_01958 904293.HMPREF9176_0571 8.4e-23 113.6 Bacilli Bacteria 1VVCA@1239,2BXK6@1,33WGZ@2,4HWEI@91061 NA|NA|NA HLLCKODE_01959 1046629.Ssal_01424 1.5e-174 618.6 Bacilli ko:K07025 ko00000 Bacteria 1V5P7@1239,4HHGY@91061,COG1011@1,COG1011@2 NA|NA|NA S hydrolase HLLCKODE_01961 904306.HMPREF9192_1153 3.3e-115 421.0 Bacilli pgm6 5.4.2.11,5.4.2.12 ko:K01834,ko:K15634 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 Bacteria 1V7EZ@1239,4HJCK@91061,COG0406@1,COG0406@2 NA|NA|NA G Phosphoglycerate mutase HLLCKODE_01962 1046629.Ssal_01422 7.9e-82 309.7 Bacilli ybaK ko:K03976 ko00000,ko01000,ko03016 Bacteria 1V6JF@1239,4HIH1@91061,COG2606@1,COG2606@2 NA|NA|NA S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily HLLCKODE_01963 435842.HMPREF0848_00353 3.6e-139 501.1 Bacilli XK27_00880 3.5.1.28 ko:K01447,ko:K07273 R04112 RC00064,RC00141 ko00000,ko01000 Bacteria 1V2YH@1239,4HI8U@91061,COG3757@1,COG3757@2 NA|NA|NA M Glycosyl hydrolase, family 25 HLLCKODE_01964 1123304.AQYA01000028_gene1720 1.5e-25 122.5 Bacteria Bacteria COG2461@1,COG2461@2 NA|NA|NA P Hemerythrin HHE cation binding domain protein HLLCKODE_01965 1046629.Ssal_01419 8.3e-137 493.0 Bacilli 5.2.1.8 ko:K03768 ko00000,ko01000,ko03110 Bacteria 1UFDJ@1239,4HDIH@91061,COG0561@1,COG0561@2 NA|NA|NA G hydrolase HLLCKODE_01966 1046629.Ssal_01418 2.6e-112 411.4 Bacilli 1.14.14.5 ko:K04091 ko00920,map00920 R07210,R10206 RC01779,RC02556 ko00000,ko00001,ko01000 Bacteria 1VJRB@1239,4ISN7@91061,COG2141@1,COG2141@2 NA|NA|NA C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases HLLCKODE_01967 904306.HMPREF9192_1160 1.7e-194 685.3 Bacilli MA20_36090 Bacteria 1VEWD@1239,4IQU0@91061,COG1073@1,COG1073@2 NA|NA|NA S Protein of unknown function (DUF2974) HLLCKODE_01968 904306.HMPREF9192_1161 1.9e-133 481.9 Bacilli sdh 1.1.1.276,1.1.1.313,1.1.1.381 ko:K05886,ko:K15373,ko:K16066 ko00240,ko00260,ko00430,ko01100,map00240,map00260,map00430,map01100 R02600,R09289,R10851,R10852 RC00087,RC00525,RC03288 ko00000,ko00001,ko01000 Bacteria 1V08N@1239,4IPTJ@91061,COG4221@1,COG4221@2 NA|NA|NA S Belongs to the short-chain dehydrogenases reductases (SDR) family HLLCKODE_01969 888049.HMPREF8578_0965 0.0 1635.2 Streptococcus oralis hsdR 3.1.21.3 ko:K01153 ko00000,ko01000,ko02048 Bacteria 1TP7S@1239,1WQ7Z@1303,4I40R@91061,COG0610@1,COG0610@2 NA|NA|NA V Type I restriction enzyme R protein N terminus (HSDR_N) HLLCKODE_01970 888049.HMPREF8578_0966 1.1e-271 942.2 Streptococcus oralis hsdM 2.1.1.72 ko:K03427 ko00000,ko01000,ko02048 Bacteria 1TPGZ@1239,1WPZV@1303,4HA1J@91061,COG0286@1,COG0286@2 NA|NA|NA V N-6 DNA Methylase HLLCKODE_01971 888816.HMPREF9389_0052 2.4e-151 542.0 Streptococcus sanguinis hsdS 3.1.21.3 ko:K01154 ko00000,ko01000,ko02048 Bacteria 1UXWC@1239,1WS6D@1305,4IKRN@91061,COG0732@1,COG0732@2 NA|NA|NA V Type I restriction modification DNA specificity domain HLLCKODE_01972 768726.HMPREF9178_0835 4.6e-93 347.4 Bacilli Bacteria 1W67F@1239,2BY08@1,2ZJ2K@2,4I272@91061 NA|NA|NA HLLCKODE_01973 768726.HMPREF9178_0834 3.5e-164 584.3 Bacilli Bacteria 1W22N@1239,28URT@1,2ZGW1@2,4I03Q@91061 NA|NA|NA HLLCKODE_01974 1046629.Ssal_01405 3.4e-189 667.5 Bacilli higA ko:K18831,ko:K21498 ko00000,ko02048,ko03000 Bacteria 1V0AU@1239,4HJU0@91061,COG3093@1,COG3093@2 NA|NA|NA K Pfam:DUF955 HLLCKODE_01975 435842.HMPREF0848_00367 1.7e-133 482.3 Bacilli Bacteria 1V1A7@1239,4HG0B@91061,COG5464@1,COG5464@2 NA|NA|NA S PD-(D/E)XK nuclease family transposase HLLCKODE_01977 1046629.Ssal_01403 0.0 1127.5 Firmicutes 2.4.1.21 ko:K00703,ko:K01990,ko:K02519,ko:K11904 ko00500,ko01100,ko01110,ko02026,ko03070,map00500,map01100,map01110,map02026,map03070 M00254,M00334,M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003,ko02000,ko02044,ko03012,ko03029 3.A.1,3.A.23.1 GT5 Bacteria 1W0JP@1239,COG5373@1,COG5373@2,COG5434@1,COG5434@2 NA|NA|NA M Right handed beta helix region HLLCKODE_01978 1046629.Ssal_01403 3.5e-29 135.6 Firmicutes 2.4.1.21 ko:K00703,ko:K01990,ko:K02519,ko:K11904 ko00500,ko01100,ko01110,ko02026,ko03070,map00500,map01100,map01110,map02026,map03070 M00254,M00334,M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003,ko02000,ko02044,ko03012,ko03029 3.A.1,3.A.23.1 GT5 Bacteria 1W0JP@1239,COG5373@1,COG5373@2,COG5434@1,COG5434@2 NA|NA|NA M Right handed beta helix region HLLCKODE_01979 1046629.Ssal_01401 4.3e-170 604.0 Bacilli spd ko:K15051 ko00000 Bacteria 1TR37@1239,4HK9Z@91061,COG2169@1,COG2169@2 NA|NA|NA F DNA RNA non-specific endonuclease HLLCKODE_01980 435842.HMPREF0848_00371 1.1e-90 339.3 Bacilli lemA ko:K03744 ko00000 Bacteria 1V1G7@1239,4IR1J@91061,COG1704@1,COG1704@2 NA|NA|NA S LemA family HLLCKODE_01981 904306.HMPREF9192_1176 3.4e-134 484.6 Bacilli htpX ko:K03799 M00743 ko00000,ko00002,ko01000,ko01002 Bacteria 1TP23@1239,4HB11@91061,COG0501@1,COG0501@2 NA|NA|NA O Belongs to the peptidase M48B family HLLCKODE_01982 1046629.Ssal_01398 9.1e-113 412.9 Bacilli sirR ko:K03709 ko00000,ko03000 Bacteria 1V4V7@1239,4HHV4@91061,COG1321@1,COG1321@2 NA|NA|NA K iron dependent repressor HLLCKODE_01983 1046629.Ssal_01397 3.3e-172 610.9 Bacilli sitA GO:0005575,GO:0005623,GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0042221,GO:0042597,GO:0044464,GO:0050896,GO:0051716,GO:0070887,GO:0071241,GO:0071248,GO:0071281 ko:K09818,ko:K11601,ko:K11604,ko:K11704,ko:K19971,ko:K19975,ko:K19976 ko02010,ko02020,map02010,map02020 M00243,M00316,M00317,M00318,M00791,M00792 ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.1,3.A.1.15.14,3.A.1.15.15,3.A.1.15.2,3.A.1.15.6,3.A.1.15.7,3.A.1.15.9 iECED1_1282.ECED1_1296 Bacteria 1TRKU@1239,4HAKT@91061,COG0803@1,COG0803@2 NA|NA|NA P Belongs to the bacterial solute-binding protein 9 family HLLCKODE_01984 1046629.Ssal_01396 8.7e-132 476.5 Bacilli mtsC GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0010035,GO:0010038,GO:0010043,GO:0016020,GO:0042221,GO:0044464,GO:0050896,GO:0071944 ko:K09819,ko:K11705,ko:K19972,ko:K19975,ko:K19976 ko02010,map02010 M00243,M00318,M00791,M00792 ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.14,3.A.1.15.15,3.A.1.15.2,3.A.1.15.6 Bacteria 1TPZB@1239,4HBD7@91061,COG1108@1,COG1108@2 NA|NA|NA P ABC-type Mn2 Zn2 transport systems, permease components HLLCKODE_01985 1046629.Ssal_01395 5.6e-127 460.3 Bacilli sitB 3.6.3.35 ko:K09817,ko:K10830,ko:K11706,ko:K11710,ko:K19973 ko02010,map02010 M00242,M00318,M00319,M00791,M00792 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15,3.A.1.15.14,3.A.1.15.15,3.A.1.15.2,3.A.1.15.3,3.A.1.15.5,3.A.1.15.6 Bacteria 1TQJ3@1239,4HA2W@91061,COG1121@1,COG1121@2 NA|NA|NA P ABC transporter, ATP-binding protein HLLCKODE_01986 1046629.Ssal_01394 2.1e-74 285.0 Bacilli ko:K16924,ko:K16927 M00582 ko00000,ko00002,ko02000 3.A.1.29,3.A.1.32 Bacteria 1V5GD@1239,4HI8Y@91061,COG4720@1,COG4720@2 NA|NA|NA S Psort location CytoplasmicMembrane, score HLLCKODE_01987 1046629.Ssal_01392 2.1e-64 251.5 Bacilli Bacteria 1VF26@1239,2DNM7@1,32Y2X@2,4HP82@91061 NA|NA|NA S Domain of unknown function (DUF4430) HLLCKODE_01988 1046629.Ssal_01391 0.0 1810.4 Bacilli ppc GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008964,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0072350 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 iJN678.ppc,iSFV_1184.SFV_4025 Bacteria 1TQB6@1239,4HCAF@91061,COG2352@1,COG2352@2 NA|NA|NA H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle HLLCKODE_01989 1046629.Ssal_01390 1.6e-183 648.7 Bacilli holA 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 1TRM0@1239,4HBB4@91061,COG1466@1,COG1466@2 NA|NA|NA L DNA polymerase III delta subunit HLLCKODE_01990 1046629.Ssal_01389 2.7e-111 407.9 Bacilli sodA GO:0005575,GO:0005576 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 ko00000,ko00001,ko01000 Bacteria 1TPXT@1239,4HA6U@91061,COG0605@1,COG0605@2 NA|NA|NA C radicals which are normally produced within the cells and which are toxic to biological systems HLLCKODE_01991 904306.HMPREF9192_1182 2.9e-164 585.1 Bacilli 3.5.2.6 ko:K17836 ko00311,ko01130,ko01501,map00311,map01130,map01501 M00627,M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000,ko01504 Bacteria 1VHF8@1239,4HU1N@91061,COG2367@1,COG2367@2 NA|NA|NA V D-alanyl-D-alanine carboxypeptidase HLLCKODE_01992 1046629.Ssal_01387 1.6e-101 375.6 Bacilli pilD 3.4.23.43 ko:K02236,ko:K02506,ko:K02654 M00331,M00429 ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 Bacteria 1TQY4@1239,4HCC3@91061,COG1989@1,COG1989@2 NA|NA|NA NOU Type II secretory pathway prepilin signal peptidase PulO and related peptidases HLLCKODE_01993 1046629.Ssal_01386 2.4e-79 301.6 Bacilli dps ko:K04047 ko00000,ko03036 Bacteria 1VCVJ@1239,4HMBD@91061,COG0783@1,COG0783@2 NA|NA|NA P Belongs to the Dps family HLLCKODE_01994 1046629.Ssal_01385 3.4e-79 300.8 Bacilli perR GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 ko:K03711,ko:K09825 ko00000,ko03000 Bacteria 1V400@1239,4HHF8@91061,COG0735@1,COG0735@2 NA|NA|NA P Belongs to the Fur family HLLCKODE_01995 435842.HMPREF0848_00386 4.2e-27 126.7 Bacilli yqgQ Bacteria 1VK83@1239,4HRG2@91061,COG4483@1,COG4483@2 NA|NA|NA S protein conserved in bacteria HLLCKODE_01996 1046629.Ssal_01383 1.1e-175 622.5 Bacilli glk GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS07790 Bacteria 1TPKW@1239,4HBAU@91061,COG1940@1,COG1940@2 NA|NA|NA G Glucokinase HLLCKODE_01997 1046629.Ssal_01382 0.0 1198.3 Bacilli typA GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840 ko:K06207 ko00000 Bacteria 1TQ5Y@1239,4HAQ6@91061,COG1217@1,COG1217@2 NA|NA|NA T GTP-binding protein TypA HLLCKODE_01999 1046629.Ssal_01380 1.5e-247 861.7 Bacilli murD 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 Bacteria 1TQ3P@1239,4HA5P@91061,COG0771@1,COG0771@2 NA|NA|NA M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) HLLCKODE_02000 1046629.Ssal_01379 4.4e-197 693.7 Bacilli murG 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 GT28 Bacteria 1TQFT@1239,4HBAQ@91061,COG0707@1,COG0707@2 NA|NA|NA M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) HLLCKODE_02001 904306.HMPREF9192_1192 2.3e-135 488.8 Firmicutes divIB ko:K03589 ko04112,map04112 ko00000,ko00001,ko03036 Bacteria 1VHEY@1239,COG1589@1,COG1589@2 NA|NA|NA D Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex HLLCKODE_02002 1046629.Ssal_01377 1e-222 779.2 Bacilli ftsA GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032153,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0071944,GO:0098552,GO:0098562 ko:K03590 ko04112,map04112 ko00000,ko00001,ko03036,ko04812 Bacteria 1TP1Z@1239,4H9NF@91061,COG0849@1,COG0849@2 NA|NA|NA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring HLLCKODE_02003 1046629.Ssal_01376 3.3e-234 817.4 Bacilli ftsZ GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0030428,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 ko:K03531 ko04112,map04112 ko00000,ko00001,ko02048,ko03036,ko04812 Bacteria 1TP6W@1239,4H9WZ@91061,COG0206@1,COG0206@2 NA|NA|NA D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity HLLCKODE_02004 1046629.Ssal_01375 6.2e-120 436.8 Bacilli ylmE GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 ko:K06997 ko00000 Bacteria 1TRDN@1239,4HC45@91061,COG0325@1,COG0325@2 NA|NA|NA S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis HLLCKODE_02005 1046629.Ssal_01374 3.4e-90 337.8 Bacteria sepF GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0022402,GO:0022607,GO:0032506,GO:0042802,GO:0044085,GO:0044464,GO:0051301,GO:0071840,GO:0071944,GO:0090529 ko:K09772 ko00000,ko03036 Bacteria COG1799@1,COG1799@2 NA|NA|NA D cell septum assembly HLLCKODE_02006 435842.HMPREF0848_00397 3.5e-31 140.6 Bacteria yggT GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02221 ko00000,ko02044 Bacteria COG0762@1,COG0762@2 NA|NA|NA D integral membrane protein HLLCKODE_02007 1046629.Ssal_01373 2.3e-137 495.0 Bacilli ylmH ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 Bacteria 1U5V2@1239,4HD3F@91061,COG2302@1,COG2302@2 NA|NA|NA S conserved protein, contains S4-like domain HLLCKODE_02008 1046629.Ssal_01372 5.5e-137 493.8 Bacilli divIVA ko:K04074 ko00000,ko03036 Bacteria 1V27M@1239,4HG80@91061,COG3599@1,COG3599@2 NA|NA|NA D Cell division initiation protein HLLCKODE_02009 1046629.Ssal_01371 0.0 1867.0 Bacilli ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iG2583_1286.G2583_0027,iPC815.YPO0475 Bacteria 1TPS7@1239,4HAWB@91061,COG0060@1,COG0060@2 NA|NA|NA J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) HLLCKODE_02010 1046629.Ssal_01369 8.5e-184 649.4 Bacilli nrdF 1.17.4.1 ko:K00526 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 Bacteria 1TQTH@1239,4H9WX@91061,COG0208@1,COG0208@2 NA|NA|NA F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides HLLCKODE_02011 1046629.Ssal_01368 0.0 1441.4 Bacilli nrdE 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 iYO844.BSU17380 Bacteria 1TPFH@1239,4H9X0@91061,COG0209@1,COG0209@2 NA|NA|NA F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides HLLCKODE_02012 264199.stu1269 6.5e-34 149.4 Bacilli nrdH GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009893,GO:0009987,GO:0016491,GO:0019222,GO:0019725,GO:0022900,GO:0042592,GO:0043085,GO:0044093,GO:0044237,GO:0045454,GO:0048518,GO:0050789,GO:0050790,GO:0050794,GO:0051341,GO:0051353,GO:0055114,GO:0065007,GO:0065008,GO:0065009 ko:K06191 ko00000 Bacteria 1VEFX@1239,4HNUX@91061,COG0695@1,COG0695@2 NA|NA|NA O Glutaredoxin HLLCKODE_02013 1046629.Ssal_01366 0.0 1750.3 Bacilli acnA GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0043937,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0050789,GO:0050793,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0065007,GO:0071704,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS06730 Bacteria 1VTMM@1239,4HB5N@91061,COG1048@1,COG1048@2 NA|NA|NA C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate HLLCKODE_02014 1046629.Ssal_01365 2.6e-208 731.1 Bacilli citZ 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1TPPS@1239,4H9YE@91061,COG0372@1,COG0372@2 NA|NA|NA C Belongs to the citrate synthase family HLLCKODE_02015 1046629.Ssal_01364 5.9e-219 766.5 Bacilli icd GO:0003674,GO:0003824,GO:0003862,GO:0004448,GO:0004450,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006520,GO:0006551,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022900,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 e_coli_core.b1136,iAF1260.b1136,iECDH1ME8569_1439.ECDH1ME8569_1071,iEcDH1_1363.EcDH1_2511,iJN746.PP_4011,iJO1366.b1136,iJR904.b1136,iY75_1357.Y75_RS05930,iYL1228.KPN_01144 Bacteria 1UHPE@1239,4H9US@91061,COG0538@1,COG0538@2 NA|NA|NA C Isocitrate dehydrogenase HLLCKODE_02016 1046629.Ssal_01363 3e-38 164.1 Bacilli ptsH GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0043610,GO:0044424,GO:0044464,GO:0050789,GO:0065007 ko:K11189 ko00000,ko02000 4.A.2.1 Bacteria 1VA0R@1239,4HKGA@91061,COG1925@1,COG1925@2 NA|NA|NA G phosphocarrier protein Hpr HLLCKODE_02017 1046629.Ssal_01362 0.0 1096.6 Bacilli ptsI GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006810,GO:0008150,GO:0008643,GO:0008965,GO:0009401,GO:0016740,GO:0016772,GO:0016775,GO:0019197,GO:0032991,GO:0042802,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0051179,GO:0051234,GO:0071702 2.7.3.9 ko:K08483 ko02060,map02060 ko00000,ko00001,ko01000,ko02000 8.A.7 iB21_1397.B21_02277,iE2348C_1286.E2348C_2602,iEC042_1314.EC042_2625,iECBD_1354.ECBD_1265,iECB_1328.ECB_02316,iECD_1391.ECD_02316,iECH74115_1262.ECH74115_3647,iECIAI1_1343.ECIAI1_2474,iECIAI39_1322.ECIAI39_2562,iECO103_1326.ECO103_2935,iECO111_1330.ECO111_3146,iECO26_1355.ECO26_3469,iECP_1309.ECP_2440,iECSE_1348.ECSE_2707,iECSP_1301.ECSP_3364,iECUMN_1333.ECUMN_2738,iECW_1372.ECW_m2645,iECs_1301.ECs3288,iEKO11_1354.EKO11_1312,iEcE24377_1341.EcE24377A_2703,iEcHS_1320.EcHS_A2551,iEcSMS35_1347.EcSMS35_2571,iEcolC_1368.EcolC_1262,iLF82_1304.LF82_1770,iNRG857_1313.NRG857_12115,iSBO_1134.SBO_2440,iSDY_1059.SDY_2613,iSFV_1184.SFV_2468,iSF_1195.SF2471,iSFxv_1172.SFxv_2720,iSSON_1240.SSON_2505,iS_1188.S2617,iUMNK88_1353.UMNK88_3018,iWFL_1372.ECW_m2645,iZ_1308.Z3682 Bacteria 1TPK8@1239,4H9VD@91061,COG1080@1,COG1080@2 NA|NA|NA G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) HLLCKODE_02018 1046629.Ssal_01360 6.6e-265 919.5 Bacilli gapN GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0043891,GO:0047100,GO:0055114 1.2.1.9 ko:K00131 ko00010,ko00030,ko01100,ko01120,ko01200,map00010,map00030,map01100,map01120,map01200 M00308,M00633 R01058 RC00242 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP4S@1239,4H9MF@91061,COG1012@1,COG1012@2 NA|NA|NA C Belongs to the aldehyde dehydrogenase family HLLCKODE_02019 1046629.Ssal_01359 4.3e-160 570.5 Bacilli XK27_05670 ko:K07017 ko00000 Bacteria 1UZZZ@1239,4HCWE@91061,COG2819@1,COG2819@2 NA|NA|NA S Putative esterase HLLCKODE_02020 1046629.Ssal_01358 2.7e-153 547.7 Bacilli XK27_05675 Bacteria 1TSKW@1239,4HB4B@91061,COG4947@1,COG4947@2 NA|NA|NA S Esterase HLLCKODE_02021 1046629.Ssal_01357 5.4e-225 786.6 Bacilli XK27_05680 6.3.2.2,6.3.2.4 ko:K01919,ko:K01921 ko00270,ko00473,ko00480,ko00550,ko01100,ko01502,map00270,map00473,map00480,map00550,map01100,map01502 M00118 R00894,R01150,R10993 RC00064,RC00090,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011 Bacteria 1UIK5@1239,4HBFS@91061,COG1181@1,COG1181@2 NA|NA|NA M carbamoylphosphate synthase large subunit HLLCKODE_02022 1046629.Ssal_01356 6e-178 630.2 Bacilli yfmL GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 ko:K05592,ko:K18692 ko03018,map03018 ko00000,ko00001,ko01000,ko03009,ko03019 Bacteria 1TQ9R@1239,4HANR@91061,COG0513@1,COG0513@2 NA|NA|NA L DEAD DEAH box helicase HLLCKODE_02023 1046629.Ssal_01355 3.1e-113 414.5 Bacilli udk GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009224,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0043771,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046035,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.1.48 ko:K00876 ko00240,ko00983,ko01100,map00240,map00983,map01100 R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232 RC00002,RC00017 ko00000,ko00001,ko01000 iSBO_1134.SBO_0893 Bacteria 1TQ4V@1239,4HAVR@91061,COG0572@1,COG0572@2 NA|NA|NA F Cytidine monophosphokinase HLLCKODE_02024 1046629.Ssal_01354 0.0 1108.2 Bacilli uup ko:K06158 ko00000,ko03012 Bacteria 1TPAX@1239,4HBVV@91061,COG0488@1,COG0488@2 NA|NA|NA S abc transporter atp-binding protein HLLCKODE_02025 435842.HMPREF0848_00417 2.7e-39 167.5 Bacilli MA20_06245 Bacteria 1VCHF@1239,4HMAW@91061,COG4298@1,COG4298@2 NA|NA|NA S yiaA/B two helix domain HLLCKODE_02026 1046629.Ssal_01352 9.7e-132 476.1 Bacilli pip 1.11.1.10 ko:K00433 ko00000,ko01000 Bacteria 1V02M@1239,4HN2K@91061,COG0596@1,COG0596@2 NA|NA|NA S Alpha beta hydrolase HLLCKODE_02027 1046629.Ssal_01351 0.0 1621.3 Bacilli mprF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.3.2.3 ko:K07027,ko:K14205 ko01503,ko02020,ko05150,map01503,map02020,map05150 M00726 ko00000,ko00001,ko00002,ko01000,ko01504,ko02000 2.A.1.3.37,4.D.2 iYO844.BG12900 Bacteria 1TQI2@1239,4HBHU@91061,COG0392@1,COG0392@2,COG2898@1,COG2898@2 NA|NA|NA J Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms HLLCKODE_02028 1046629.Ssal_01350 8.1e-148 529.6 Bacilli cobQ ko:K07009 ko00000 Bacteria 1U7I9@1239,4HD1P@91061,COG3442@1,COG3442@2 NA|NA|NA S glutamine amidotransferase HLLCKODE_02029 1046629.Ssal_01349 8.4e-254 882.5 Bacilli murD 3.4.21.10,6.3.2.13,6.3.2.9 ko:K01317,ko:K01925,ko:K01928,ko:K01932 ko00300,ko00471,ko00550,ko01100,map00300,map00471,map00550,map01100 R02783,R02788 RC00064,RC00090,RC00141 ko00000,ko00001,ko01000,ko01002,ko01011,ko04131 Bacteria 1UHPI@1239,4HVP0@91061,COG0771@1,COG0771@2 NA|NA|NA M Mur ligase, middle domain protein HLLCKODE_02030 904306.HMPREF9192_1521 2.7e-149 534.6 Bacilli dacA GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009975,GO:0016020,GO:0016021,GO:0016829,GO:0016849,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 2.7.7.85 ko:K18672 ko00000,ko01000 Bacteria 1TPRW@1239,4H9XZ@91061,COG1624@1,COG1624@2 NA|NA|NA S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria HLLCKODE_02031 1046629.Ssal_01347 3.2e-162 577.8 Bacilli ybbR GO:0008150,GO:0031279,GO:0031281,GO:0043085,GO:0044093,GO:0045761,GO:0045762,GO:0050790,GO:0051339,GO:0051349,GO:0065007,GO:0065009 Bacteria 1TSIV@1239,4HD8Y@91061,COG4856@1,COG4856@2 NA|NA|NA S Protein conserved in bacteria HLLCKODE_02032 1046629.Ssal_01346 3.7e-249 867.1 Bacilli glmM GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006468,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008966,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019538,GO:0034641,GO:0034654,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046777,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 R02060 RC00408 ko00000,ko00001,ko01000 iSB619.SA_RS11275,iSBO_1134.SBO_3206 Bacteria 1TP1X@1239,4HB16@91061,COG1109@1,COG1109@2 NA|NA|NA G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate HLLCKODE_02033 1046629.Ssal_01345 1.8e-66 258.5 Bacilli gtrA GO:0000166,GO:0003674,GO:0003824,GO:0003870,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008883,GO:0009058,GO:0009987,GO:0016020,GO:0016410,GO:0016491,GO:0016620,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016749,GO:0016903,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0036094,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 Bacteria 1VMS6@1239,4HNB7@91061,COG2246@1,COG2246@2 NA|NA|NA S GtrA-like protein HLLCKODE_02034 1046629.Ssal_01344 3.7e-120 437.6 Bacilli trmK GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.217 ko:K06967 ko00000,ko01000,ko03016 Bacteria 1V3I4@1239,4HHIM@91061,COG2384@1,COG2384@2 NA|NA|NA S SAM-dependent methyltransferase HLLCKODE_02035 1046629.Ssal_01343 1.3e-142 512.3 Bacilli yqfO GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.5.4.16 ko:K22391 ko00790,ko01100,map00790,map01100 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQ27@1239,4H9NY@91061,COG0327@1,COG0327@2 NA|NA|NA S Belongs to the GTP cyclohydrolase I type 2 NIF3 family HLLCKODE_02036 1046629.Ssal_01342 1.1e-144 519.2 Bacilli zupT ko:K07238 ko00000,ko02000 2.A.5.5 Bacteria 1TP7J@1239,4HB3R@91061,COG0428@1,COG0428@2 NA|NA|NA P Mediates zinc uptake. May also transport other divalent cations HLLCKODE_02037 1046629.Ssal_01341 5.1e-193 680.2 Bacilli yurR GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0044424,GO:0044464,GO:0055114 1.4.5.1 ko:K00285 ko00360,map00360 R01374,R09493 RC00006,RC00025 ko00000,ko00001,ko01000 Bacteria 1TQTF@1239,4HA0F@91061,COG0665@1,COG0665@2 NA|NA|NA E oxidoreductase HLLCKODE_02038 1046629.Ssal_01340 9e-256 889.0 Bacilli Bacteria 1TRER@1239,4IQ64@91061,COG4099@1,COG4099@2 NA|NA|NA S phospholipase Carboxylesterase HLLCKODE_02039 1046629.Ssal_01339 3.2e-161 574.3 Bacilli rfbA GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0005996,GO:0006006,GO:0006139,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008879,GO:0009058,GO:0009059,GO:0009117,GO:0009141,GO:0009147,GO:0009200,GO:0009211,GO:0009219,GO:0009225,GO:0009226,GO:0009262,GO:0009394,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019299,GO:0019300,GO:0019305,GO:0019318,GO:0019319,GO:0019438,GO:0019637,GO:0019692,GO:0030312,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0045226,GO:0046075,GO:0046364,GO:0046379,GO:0046383,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv0334 Bacteria 1V301@1239,4H9R0@91061,COG1209@1,COG1209@2 NA|NA|NA M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis HLLCKODE_02040 1046629.Ssal_01338 2.7e-111 407.9 Bacilli rmlC 1.1.1.133,5.1.3.13 ko:K00067,ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777,R06514 RC00182,RC01531 ko00000,ko00001,ko00002,ko01000 Bacteria 1TRVB@1239,4HFQB@91061,COG1898@1,COG1898@2 NA|NA|NA M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose HLLCKODE_02041 435842.HMPREF0848_00434 1.3e-204 718.8 Bacilli rfbB GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0008460,GO:0009058,GO:0009059,GO:0009987,GO:0016051,GO:0016829,GO:0016835,GO:0016836,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0045226,GO:0046379,GO:0071704,GO:1901576 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPWM@1239,4HA3Y@91061,COG1088@1,COG1088@2 NA|NA|NA M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily HLLCKODE_02044 888833.HMPREF9421_0631 5.7e-31 141.4 Bacteria Bacteria COG4640@1,COG4640@2 NA|NA|NA KT response to antibiotic HLLCKODE_02045 435842.HMPREF0848_00437 2.6e-216 757.7 Bacilli hemN GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 Bacteria 1TPES@1239,4HA60@91061,COG0635@1,COG0635@2 NA|NA|NA H Involved in the biosynthesis of porphyrin-containing compound HLLCKODE_02046 435842.HMPREF0848_00438 4.8e-110 404.1 Bacilli fat 3.1.2.21 ko:K01071 ko00061,ko01100,map00061,map01100 R04014,R08157,R08158 RC00014,RC00039 ko00000,ko00001,ko01000,ko01004 Bacteria 1V3RB@1239,4HHJ4@91061,COG3884@1,COG3884@2 NA|NA|NA I Acyl-ACP thioesterase HLLCKODE_02047 36874.HQ34_09795 2.5e-32 146.0 Bacteroidetes Bacteria 2D62R@1,32TKD@2,4NTYM@976 NA|NA|NA S TIR domain HLLCKODE_02048 1005705.HMPREF9967_1362 1.6e-135 488.8 Streptococcus infantis nagD 2.7.1.25,3.1.3.41 ko:K00860,ko:K01101 ko00230,ko00627,ko00920,ko01100,ko01120,map00230,map00627,map00920,map01100,map01120 M00176 R00509,R03024,R04928 RC00002,RC00078,RC00151 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQGM@1239,43FN9@68892,4HA3R@91061,COG0647@1,COG0647@2 NA|NA|NA G Haloacid dehalogenase-like hydrolase HLLCKODE_02049 322159.STER_1213 1.1e-113 416.0 Bacilli ylfI Bacteria 1VGZ1@1239,4HNTM@91061,COG4478@1,COG4478@2 NA|NA|NA S tigr01906 HLLCKODE_02050 904306.HMPREF9192_1539 3.3e-135 487.6 Bacilli hisK 3.1.3.15 ko:K04486 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013 RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 1V77D@1239,4HGYX@91061,COG1387@1,COG1387@2 NA|NA|NA E Histidinol phosphatase and related hydrolases of the PHP family HLLCKODE_02051 435842.HMPREF0848_00448 5.2e-146 523.9 Bacilli XK27_08080 3.1.1.53 ko:K05970 ko00000,ko01000 Bacteria 1TR6Z@1239,4HGB0@91061,COG4632@1,COG4632@2 NA|NA|NA G Exopolysaccharide biosynthesis protein HLLCKODE_02052 435842.HMPREF0848_00449 8.6e-58 229.6 Firmicutes XK27_08085 Bacteria 1VM50@1239,2EJUK@1,33DJ8@2 NA|NA|NA HLLCKODE_02053 435842.HMPREF0848_00450 3.6e-191 674.1 Bacilli hisC 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 iJN678.hisC Bacteria 1TPUV@1239,4HA1H@91061,COG0079@1,COG0079@2 NA|NA|NA E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily HLLCKODE_02054 435842.HMPREF0848_00451 7.2e-178 629.8 Bacilli hisZ 2.4.2.17,6.1.1.21 ko:K00765,ko:K01892,ko:K02502 ko00340,ko00970,ko01100,ko01110,ko01230,map00340,map00970,map01100,map01110,map01230 M00026,M00359,M00360 R01071,R03655 RC00055,RC00523,RC02819,RC03200 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1TPZZ@1239,4HBBA@91061,COG3705@1,COG3705@2 NA|NA|NA E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine HLLCKODE_02055 1046629.Ssal_01323 5.2e-116 423.7 Bacilli hisG GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 ko:K00765,ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 Bacteria 1TSVZ@1239,4H9MH@91061,COG0040@1,COG0040@2 NA|NA|NA E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity HLLCKODE_02056 1046629.Ssal_01322 7.1e-234 816.2 Bacilli hisD GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23,1.1.1.308 ko:K00013,ko:K15509 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPAW@1239,4H9XK@91061,COG0141@1,COG0141@2 NA|NA|NA E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine HLLCKODE_02057 1046629.Ssal_01321 2e-106 391.7 Bacilli hisB GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0004424,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042578,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23,2.6.1.9,3.1.3.15,4.2.1.19 ko:K00013,ko:K00817,ko:K01089,ko:K01693 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R01158,R01163,R03012,R03013,R03243,R03457 RC00006,RC00017,RC00099,RC00242,RC00463,RC00888,RC00932 ko00000,ko00001,ko00002,ko01000,ko01007 iECO111_1330.ECO111_2746,iECS88_1305.ECS88_2121,iJN746.PP_0289,iLJ478.TM1039,iSB619.SA_RS14130,iUMNK88_1353.UMNK88_2570 Bacteria 1TRH7@1239,4HCFG@91061,COG0131@1,COG0131@2 NA|NA|NA E imidazoleglycerol-phosphate dehydratase HLLCKODE_02058 1046629.Ssal_01320 2.3e-110 404.8 Bacilli hisH ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQT0@1239,4HFXQ@91061,COG0118@1,COG0118@2 NA|NA|NA E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR HLLCKODE_02059 1046629.Ssal_01319 1.1e-130 472.6 Bacilli hisA GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_0388 Bacteria 1V1IR@1239,4HACP@91061,COG0106@1,COG0106@2 NA|NA|NA E 1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase HLLCKODE_02060 435842.HMPREF0848_00457 2.8e-137 494.6 Bacilli hisF GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009382,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 3.5.4.19,3.6.1.31 ko:K01663,ko:K02500,ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037,R04558 RC00002,RC00010,RC01055,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 iECO111_1330.ECO111_2749,iEcolC_1368.EcolC_1617,iHN637.CLJU_RS05755,iLJ478.TM1036,iSB619.SA_RS14115,iYL1228.KPN_02481 Bacteria 1TP0W@1239,4HAAM@91061,COG0107@1,COG0107@2 NA|NA|NA E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit HLLCKODE_02061 1046629.Ssal_01317 3.6e-60 237.3 Bacilli hisI GO:0000105,GO:0003674,GO:0003824,GO:0004635,GO:0004636,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.4.19,3.5.4.25,3.6.1.31,5.3.1.16 ko:K01496,ko:K01497,ko:K01814,ko:K11755 ko00340,ko00740,ko00790,ko01100,ko01110,ko01230,ko02024,map00340,map00740,map00790,map01100,map01110,map01230,map02024 M00026,M00125 R00425,R04035,R04037,R04640 RC00002,RC00293,RC00945,RC01055,RC02504 ko00000,ko00001,ko00002,ko01000 iECNA114_1301.ECNA114_0880,iECW_1372.ECW_m2186,iEKO11_1354.EKO11_1768,iHN637.CLJU_RS05760,iSB619.SA_RS14110,iUMN146_1321.UM146_06665,iWFL_1372.ECW_m2186 Bacteria 1UYNA@1239,4HA9R@91061,COG0139@1,COG0139@2 NA|NA|NA E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP HLLCKODE_02062 1046629.Ssal_01315 6.9e-50 203.0 Bacteria hisE GO:0000105,GO:0000287,GO:0003674,GO:0003824,GO:0004636,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052803,GO:0071704,GO:0071944,GO:0075136,GO:0075139,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.4.19,3.6.1.31,5.3.1.16 ko:K01523,ko:K01814,ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037,R04640 RC00002,RC00945,RC01055 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS14110,iYO844.BSU34860 Bacteria COG0140@1,COG0140@2 NA|NA|NA E phosphoribosyl-ATP diphosphatase activity HLLCKODE_02064 1046629.Ssal_01313 6.5e-93 347.1 Firmicutes XK27_05505 Bacteria 1V1GI@1239,COG1285@1,COG1285@2 NA|NA|NA S Psort location CytoplasmicMembrane, score HLLCKODE_02065 1046629.Ssal_01312 1.4e-144 518.8 Bacilli Bacteria 1V1FZ@1239,4HJFI@91061,COG5036@1,COG5036@2 NA|NA|NA P molecular chaperone HLLCKODE_02066 1046629.Ssal_01311 1.4e-104 386.7 Bacilli Bacteria 1TZ8N@1239,2Z8AD@2,4HV65@91061,arCOG08054@1 NA|NA|NA S Carbohydrate-binding domain-containing protein Cthe_2159 HLLCKODE_02067 1046629.Ssal_01310 7.5e-178 629.8 Bacilli XK27_08075 Bacteria 1UIHV@1239,4ISID@91061,COG1216@1,COG1216@2,COG2246@1,COG2246@2 NA|NA|NA M glycosyl transferase family 2 HLLCKODE_02068 1046629.Ssal_01309 0.0 2332.4 Bacilli 2.4.1.5 ko:K00689,ko:K20276 ko00500,ko02020,ko02024,map00500,map02020,map02024 R02120,R06066 RC00028 ko00000,ko00001,ko01000 GH13 Bacteria 1VQXK@1239,4HEIA@91061,COG0366@1,COG0366@2,COG5263@1,COG5263@2 NA|NA|NA M KxYKxGKxW signal domain protein HLLCKODE_02069 1046629.Ssal_01308 0.0 2576.2 Bacilli 2.4.1.5 ko:K00689,ko:K20276 ko00500,ko02020,ko02024,map00500,map02020,map02024 R02120,R06066 RC00028 ko00000,ko00001,ko01000 GH13 Bacteria 1VQXK@1239,4HEIA@91061,COG0366@1,COG0366@2,COG5263@1,COG5263@2 NA|NA|NA M KxYKxGKxW signal domain protein HLLCKODE_02071 1123298.KB904069_gene1213 8.3e-17 92.4 Bacteria atpE GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 Bacteria 2ZI0B@2,COG0636@1 NA|NA|NA C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation HLLCKODE_02072 1046629.Ssal_01685 1.8e-122 445.3 Bacilli atpB GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 iAPECO1_1312.APECO1_2725,iE2348C_1286.E2348C_4048,iEC042_1314.EC042_4125,iECABU_c1320.ECABU_c42230,iECED1_1282.ECED1_4428,iECIAI39_1322.ECIAI39_4342,iECNA114_1301.ECNA114_3887,iECOK1_1307.ECOK1_4187,iECP_1309.ECP_3937,iECS88_1305.ECS88_4160,iECSF_1327.ECSF_3586,iECUMN_1333.ECUMN_4268,iEcSMS35_1347.EcSMS35_4106,iLF82_1304.LF82_0192,iNRG857_1313.NRG857_18615,iUMN146_1321.UM146_18880,iUMNK88_1353.UMNK88_4550,iUTI89_1310.UTI89_C4293,ic_1306.c4666 Bacteria 1TQIT@1239,4H9NV@91061,COG0356@1,COG0356@2 NA|NA|NA C it plays a direct role in the translocation of protons across the membrane HLLCKODE_02073 1046629.Ssal_01684 9.5e-78 296.2 Bacilli atpF ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 iHN637.CLJU_RS01170,iYO844.BSU36850 Bacteria 1VB85@1239,4HM64@91061,COG0711@1,COG0711@2 NA|NA|NA C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) HLLCKODE_02074 1046629.Ssal_01683 2.3e-85 321.6 Bacilli atpH GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 iSF_1195.SF3815,iSFxv_1172.SFxv_4157,iS_1188.S3953 Bacteria 1VAG3@1239,4HKW1@91061,COG0712@1,COG0712@2 NA|NA|NA C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation HLLCKODE_02075 904306.HMPREF9192_0397 5e-279 966.5 Bacilli atpA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 iIT341.HP1134,iSB619.SA_RS10975,iSbBS512_1146.SbBS512_E4187 Bacteria 1TNZ8@1239,4HAMZ@91061,COG0056@1,COG0056@2 NA|NA|NA C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit HLLCKODE_02076 1046629.Ssal_01681 4.8e-157 560.5 Bacilli atpG GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 iLJ478.TM1611,iSB619.SA_RS10970,iYO844.BSU36820 Bacteria 1TPBX@1239,4HB0E@91061,COG0224@1,COG0224@2 NA|NA|NA C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex HLLCKODE_02077 1046629.Ssal_01680 6.7e-262 909.4 Bacilli atpD 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 iSB619.SA_RS10965 Bacteria 1TPGF@1239,4HAT6@91061,COG0055@1,COG0055@2 NA|NA|NA C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits HLLCKODE_02078 1046629.Ssal_01679 2.6e-68 264.6 Bacilli atpC GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 iJN746.PP_5412,iSbBS512_1146.SbBS512_E4190 Bacteria 1VA89@1239,4HKHS@91061,COG0355@1,COG0355@2 NA|NA|NA C Produces ATP from ADP in the presence of a proton gradient across the membrane HLLCKODE_02079 435842.HMPREF0848_00121 6e-217 760.0 Bacilli ftsW ko:K03588 ko04112,map04112 ko00000,ko00001,ko02000,ko03036 2.A.103.1 Bacteria 1TPT7@1239,4HAEV@91061,COG0772@1,COG0772@2 NA|NA|NA D Belongs to the SEDS family HLLCKODE_02080 1046629.Ssal_01677 1.6e-224 785.0 Bacilli tuf GO:0001817,GO:0001819,GO:0002791,GO:0002793,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009274,GO:0009275,GO:0009986,GO:0010339,GO:0016020,GO:0022610,GO:0030312,GO:0032677,GO:0032757,GO:0032879,GO:0032880,GO:0035821,GO:0044003,GO:0044068,GO:0044403,GO:0044406,GO:0044419,GO:0044424,GO:0044426,GO:0044462,GO:0044464,GO:0044650,GO:0044651,GO:0048518,GO:0048522,GO:0050707,GO:0050708,GO:0050714,GO:0050715,GO:0050789,GO:0050794,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051222,GO:0051223,GO:0051239,GO:0051240,GO:0051701,GO:0051704,GO:0051817,GO:0065007,GO:0070201,GO:0071944,GO:0090087,GO:1903530,GO:1903532,GO:1904951,GO:2000482,GO:2000484 ko:K02358,ko:K15771 ko02010,map02010 M00491 ko00000,ko00001,ko00002,ko02000,ko03012,ko03029,ko04147 3.A.1.1.16,3.A.1.1.2 Bacteria 1TPKC@1239,4HAEH@91061,COG0050@1,COG0050@2 NA|NA|NA J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis HLLCKODE_02081 1046629.Ssal_01675 5.8e-135 486.9 Bacilli tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 2.7.2.3,5.3.1.1 ko:K00927,ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01015,R01512 RC00002,RC00043,RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 iHN637.CLJU_RS19265 Bacteria 1TP2F@1239,4HAPT@91061,COG0149@1,COG0149@2 NA|NA|NA G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) HLLCKODE_02082 435842.HMPREF0848_00124 0.0 1278.8 Bacilli tkt 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPIB@1239,4HADA@91061,COG0021@1,COG0021@2 NA|NA|NA G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate HLLCKODE_02084 904306.HMPREF9192_0405 2.9e-108 397.9 Bacilli tmk GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS02535 Bacteria 1V1HE@1239,4HGWR@91061,COG0125@1,COG0125@2 NA|NA|NA F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis HLLCKODE_02085 904306.HMPREF9192_0406 1.7e-159 568.5 Bacilli holB 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 1TRVS@1239,4HA3T@91061,COG0470@1,COG0470@2 NA|NA|NA L dna polymerase iii HLLCKODE_02086 1046629.Ssal_01671 5.8e-133 480.3 Bacilli yaaT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 Bacteria 1TP1V@1239,4H9M9@91061,COG1774@1,COG1774@2 NA|NA|NA S stage 0 sporulation protein HLLCKODE_02087 1046629.Ssal_01670 1.2e-54 218.8 Bacilli yabA GO:0003674,GO:0005488,GO:0005515,GO:0042802 Bacteria 1VA1F@1239,4HKND@91061,COG4467@1,COG4467@2 NA|NA|NA L Involved in initiation control of chromosome replication HLLCKODE_02088 1046629.Ssal_01669 3.3e-158 564.3 Bacilli rsmI GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.198 ko:K07056 ko00000,ko01000,ko03009 Bacteria 1TP6U@1239,4HAH8@91061,COG0313@1,COG0313@2 NA|NA|NA H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA HLLCKODE_02089 435842.HMPREF0848_00130 8.7e-26 122.9 Bacilli amt ko:K03320 ko00000,ko02000 1.A.11 Bacteria 1TQYG@1239,4HBGK@91061,COG0004@1,COG0004@2 NA|NA|NA P Ammonium Transporter HLLCKODE_02090 1046629.Ssal_01666 4.6e-104 384.0 Bacteria mur1 3.4.17.14,3.5.1.28 ko:K01448,ko:K02395,ko:K07260 ko00550,ko01100,ko01502,ko01503,ko02020,map00550,map01100,map01502,map01503,map02020 M00651,M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504,ko02035,ko03036 Bacteria COG1705@1,COG1705@2 NA|NA|NA NU amidase activity HLLCKODE_02091 904306.HMPREF9192_0413 5.9e-141 506.9 Bacilli XK27_04800 Bacteria 1V1KS@1239,4IPK6@91061,COG0561@1,COG0561@2 NA|NA|NA S Sucrose-6F-phosphate phosphohydrolase HLLCKODE_02092 435842.HMPREF0848_00134 5.4e-76 290.4 Firmicutes Bacteria 1VMYY@1239,2E80M@1,33I28@2 NA|NA|NA S Bacterial inner membrane protein HLLCKODE_02093 1046629.Ssal_01662 1.4e-113 416.4 Bacteria 3.4.17.14,3.5.1.28 ko:K01448,ko:K02395,ko:K07260 ko00550,ko01100,ko01502,ko01503,ko02020,map00550,map01100,map01502,map01503,map02020 M00651,M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504,ko02035,ko03036 Bacteria COG1705@1,COG1705@2 NA|NA|NA NU amidase activity HLLCKODE_02094 1046629.Ssal_01661 3.5e-294 1016.9 Bacilli nptA ko:K03324 ko00000,ko02000 2.A.58.2 Bacteria 1TP4K@1239,4HAZ0@91061,COG1283@1,COG1283@2 NA|NA|NA P COG1283 Na phosphate symporter HLLCKODE_02095 1046629.Ssal_01660 2e-219 768.1 Bacilli nagA 3.5.1.25 ko:K01443 ko00520,ko01130,map00520,map01130 R02059 RC00166,RC00300 ko00000,ko00001,ko01000 Bacteria 1TPFK@1239,4HC6C@91061,COG1820@1,COG1820@2 NA|NA|NA G Belongs to the metallo-dependent hydrolases superfamily. NagA family HLLCKODE_02096 1046629.Ssal_01659 1e-221 775.8 Bacilli Bacteria 1U601@1239,4HBYW@91061,COG3949@1,COG3949@2 NA|NA|NA S membrane HLLCKODE_02097 1046629.Ssal_01658 6.3e-176 623.2 Bacilli glyQ GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016874,GO:0016875,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0140098,GO:0140101 6.1.1.14 ko:K01878,ko:K14164 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iAF1260.b3560,iAF987.Gmet_2942,iJO1366.b3560,iPC815.YPO4072,iY75_1357.Y75_RS19360 Bacteria 1TPW8@1239,4HBCF@91061,COG0752@1,COG0752@2 NA|NA|NA J glycyl-tRNA synthetase alpha subunit HLLCKODE_02098 1046629.Ssal_01657 0.0 1270.4 Bacilli glyS GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.14 ko:K01879,ko:K14164 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iAPECO1_1312.APECO1_2891,iE2348C_1286.E2348C_3810,iECABU_c1320.ECABU_c40010,iECED1_1282.ECED1_4242,iECH74115_1262.ECH74115_4934,iECNA114_1301.ECNA114_3710,iECOK1_1307.ECOK1_4005,iECP_1309.ECP_3661,iECS88_1305.ECS88_3976,iECSF_1327.ECSF_3393,iECSP_1301.ECSP_4554,iECs_1301.ECs4442,iG2583_1286.G2583_4300,iJN678.glyS,iUMN146_1321.UM146_17960,iUTI89_1310.UTI89_C4099,ic_1306.c4378 Bacteria 1TNZ7@1239,4H9NT@91061,COG0751@1,COG0751@2 NA|NA|NA J Glycyl-tRNA synthetase beta subunit HLLCKODE_02099 1046629.Ssal_01656 1.7e-38 164.9 Bacilli ynzC Bacteria 1VEKJ@1239,4HNIB@91061,COG4224@1,COG4224@2 NA|NA|NA S UPF0291 protein HLLCKODE_02100 1046629.Ssal_01655 4.8e-252 876.7 Bacilli cycA GO:0001761,GO:0001762,GO:0003333,GO:0003674,GO:0005215,GO:0005326,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015180,GO:0015187,GO:0015238,GO:0015318,GO:0015711,GO:0015804,GO:0015807,GO:0015808,GO:0015816,GO:0015849,GO:0015893,GO:0016020,GO:0022857,GO:0022858,GO:0022889,GO:0032328,GO:0032329,GO:0034220,GO:0042221,GO:0042493,GO:0042891,GO:0042895,GO:0042940,GO:0042941,GO:0042942,GO:0042943,GO:0042944,GO:0042945,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903825,GO:1905039 ko:K03293,ko:K11737 ko00000,ko02000 2.A.3.1,2.A.3.1.7 iECO111_1330.ECO111_5093,iECO26_1355.ECO26_5376,iEcHS_1320.EcHS_A4458,iSbBS512_1146.SbBS512_E4749,iYL1228.KPN_04601 Bacteria 1TP97@1239,4H9QX@91061,COG1113@1,COG1113@2 NA|NA|NA E permease HLLCKODE_02101 1215915.BN193_08720 6.4e-10 71.2 Lactococcus uvrX 2.7.7.7 ko:K02346,ko:K03502,ko:K14161 ko00000,ko01000,ko03400 Bacteria 1TP42@1239,1YBFV@1357,4HA1P@91061,COG0389@1,COG0389@2 NA|NA|NA L impB/mucB/samB family HLLCKODE_02102 1046629.Ssal_01653 0.0 1184.1 Bacilli pts33BCA 2.7.1.201,2.7.1.208,2.7.1.211 ko:K02755,ko:K02756,ko:K02757,ko:K02777,ko:K02808,ko:K02809,ko:K02810,ko:K02817,ko:K02818,ko:K02819,ko:K20107,ko:K20108 ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111 M00265,M00266,M00268,M00269,M00270,M00271,M00272,M00303,M00806 R00811,R02738,R02780,R04111,R04394,R05132,R08559 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.1,4.A.1.1.11,4.A.1.1.12,4.A.1.2.1,4.A.1.2.10,4.A.1.2.11,4.A.1.2.12,4.A.1.2.13,4.A.1.2.2,4.A.1.2.4,4.A.1.2.5,4.A.1.2.6,4.A.1.2.8,4.A.1.2.9 Bacteria 1TP5X@1239,4HA0I@91061,COG1263@1,COG1263@2,COG1264@1,COG1264@2,COG2190@1,COG2190@2 NA|NA|NA G pts system HLLCKODE_02103 1046629.Ssal_01652 3e-139 501.1 Bacteria ppiA 5.2.1.8 ko:K01802,ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 ko00000,ko00001,ko01000,ko03110,ko04147 Bacteria COG0652@1,COG0652@2 NA|NA|NA O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides HLLCKODE_02107 1046629.Ssal_00998 3.9e-154 550.8 Bacilli ko:K01990,ko:K07023 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1V5JQ@1239,4HM69@91061,COG1131@1,COG1131@2 NA|NA|NA V AAA domain, putative AbiEii toxin, Type IV TA system HLLCKODE_02108 1121864.OMO_01583 2.4e-56 225.7 Bacilli Bacteria 1UKKF@1239,2DX6G@1,343KN@2,4HVY2@91061 NA|NA|NA S ABC-2 type transporter HLLCKODE_02109 1046629.Ssal_01001 8.2e-97 359.8 Bacilli Bacteria 1W0N0@1239,2FFHU@1,347FA@2,4HZDI@91061 NA|NA|NA HLLCKODE_02111 1046629.Ssal_01647 1.2e-166 592.4 Bacilli fhuR Bacteria 1V53I@1239,4HIEU@91061,COG0583@1,COG0583@2 NA|NA|NA K transcriptional regulator (lysR family) HLLCKODE_02112 1046629.Ssal_01646 2.8e-76 291.2 Bacilli lspA 3.4.23.36 ko:K03101 ko03060,map03060 ko00000,ko00001,ko01000,ko01002 Bacteria 1VA9R@1239,4HIR4@91061,COG0597@1,COG0597@2 NA|NA|NA MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins HLLCKODE_02113 435842.HMPREF0848_00153 1.6e-160 572.0 Bacilli rluD GO:0000027,GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022607,GO:0022613,GO:0022618,GO:0031118,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 ko:K06180 ko00000,ko01000,ko03009 iE2348C_1286.E2348C_2868,iECED1_1282.ECED1_3035,iECSF_1327.ECSF_2432 Bacteria 1TPCM@1239,4HBG2@91061,COG0564@1,COG0564@2 NA|NA|NA J Responsible for synthesis of pseudouridine from uracil HLLCKODE_02114 1046629.Ssal_01644 1.8e-87 328.6 Bacilli pyrR 2.4.2.9 ko:K02825 ko00240,ko01100,map00240,map01100 R00966 RC00063 ko00000,ko00001,ko01000,ko03000 Bacteria 1V3GV@1239,4HGYE@91061,COG2065@1,COG2065@2 NA|NA|NA F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant HLLCKODE_02115 1046629.Ssal_01642 4.9e-219 766.9 Bacilli pyrP ko:K02824,ko:K16169 ko00000,ko02000 2.A.40.1.1,2.A.40.1.2,2.A.40.3.1 iLJ478.TM0819 Bacteria 1TQKX@1239,4HAEU@91061,COG2233@1,COG2233@2 NA|NA|NA F uracil Permease HLLCKODE_02116 1046629.Ssal_01641 1.3e-173 615.5 Bacilli pyrB GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 ko:K00608,ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 iYO844.BSU15490 Bacteria 1TQ96@1239,4H9M6@91061,COG0540@1,COG0540@2 NA|NA|NA F Belongs to the ATCase OTCase family HLLCKODE_02117 1046629.Ssal_01640 4.6e-210 736.9 Bacilli carA GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01955,ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1383,iYO844.BSU15510 Bacteria 1TQ8N@1239,4H9Z0@91061,COG0505@1,COG0505@2 NA|NA|NA F carbamoyl-phosphate synthetase glutamine chain HLLCKODE_02118 904306.HMPREF9192_0437 0.0 2061.6 Bacilli carB GO:0000050,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPID@1239,4HAEY@91061,COG0458@1,COG0458@2 NA|NA|NA F carbamoyl-phosphate synthetase ammonia chain HLLCKODE_02119 435842.HMPREF0848_00160 6.6e-123 446.8 Bacilli rsmJ 2.1.1.242 ko:K15984 ko00000,ko01000,ko03009 Bacteria 1V4AQ@1239,4HHBA@91061,COG2265@1,COG2265@2 NA|NA|NA J Putative SAM-dependent methyltransferase HLLCKODE_02120 435842.HMPREF0848_00161 6.8e-181 640.2 Bacilli acrA GO:0003674,GO:0005488,GO:0005515,GO:0042802 ko:K02005 ko00000 Bacteria 1VBR9@1239,4HG5X@91061,COG0845@1,COG0845@2 NA|NA|NA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family HLLCKODE_02121 904306.HMPREF9192_0440 2e-121 441.8 Bacilli macB ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TPBJ@1239,4HBMF@91061,COG1136@1,COG1136@2 NA|NA|NA V ABC transporter, ATP-binding protein HLLCKODE_02122 435842.HMPREF0848_00163 3.8e-213 747.3 Bacilli ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TPUU@1239,4HF9U@91061,COG0577@1,COG0577@2 NA|NA|NA V permease protein HLLCKODE_02123 435842.HMPREF0848_00164 5.6e-78 297.0 Bacilli rplJ GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0017148,GO:0019222,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02864,ko:K02935 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V3JJ@1239,4HH0N@91061,COG0244@1,COG0244@2 NA|NA|NA J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors HLLCKODE_02124 264199.stu0537 2.1e-45 188.3 Bacilli rplL ko:K02935 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V6EI@1239,4HIGQ@91061,COG0222@1,COG0222@2 NA|NA|NA J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation HLLCKODE_02125 1123311.KB904456_gene716 3e-21 107.8 Bacilli XK27_00530 Bacteria 1VPFZ@1239,4HFGV@91061,COG3942@1,COG3942@2 NA|NA|NA M CHAP domain protein HLLCKODE_02126 435842.HMPREF0848_00171 1.7e-102 378.6 Bacilli abiGI Bacteria 1V3JU@1239,4HMVW@91061,COG5340@1,COG5340@2 NA|NA|NA K Transcriptional regulator, AbiEi antitoxin HLLCKODE_02127 1046629.Ssal_01630 2.7e-272 944.1 Bacilli opuD GO:0003674,GO:0005215,GO:0006810,GO:0006811,GO:0006812,GO:0006950,GO:0006970,GO:0008150,GO:0008324,GO:0008519,GO:0009266,GO:0009409,GO:0009628,GO:0015075,GO:0015101,GO:0015199,GO:0015651,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0022857,GO:0031460,GO:0034220,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0072337,GO:0072349,GO:0072488,GO:0098655 ko:K05020 ko00000,ko02000 2.A.15.1.1,2.A.15.1.11 Bacteria 1TRS6@1239,4HA7U@91061,COG1292@1,COG1292@2 NA|NA|NA M Belongs to the BCCT transporter (TC 2.A.15) family HLLCKODE_02128 1046629.Ssal_01629 2.4e-18 97.1 Bacteria ko:K02051 M00188 ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 Bacteria COG0583@1,COG0583@2 NA|NA|NA K DNA-binding transcription factor activity HLLCKODE_02129 435842.HMPREF0848_00173 0.0 1097.0 Bacilli mdlB ko:K06147,ko:K18887 ko02010,map02010 M00706 ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 1TP0B@1239,4H9SC@91061,COG1132@1,COG1132@2 NA|NA|NA V abc transporter atp-binding protein HLLCKODE_02130 1046629.Ssal_01626 0.0 1117.1 Bacilli lmrA ko:K06147,ko:K18888 ko02010,map02010 M00706 ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 1TP0B@1239,4HA3S@91061,COG1132@1,COG1132@2 NA|NA|NA V abc transporter atp-binding protein HLLCKODE_02131 435842.HMPREF0848_00175 6.6e-198 696.4 Bacilli queA GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 ko:K07568 ko00000,ko01000,ko03016 Bacteria 1TPKD@1239,4H9PT@91061,COG0809@1,COG0809@2 NA|NA|NA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) HLLCKODE_02132 1046629.Ssal_01624 8.9e-122 443.0 Bacilli nagB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006040,GO:0008150,GO:0008152,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901135 3.1.1.31,3.5.99.6 ko:K01057,ko:K02564 ko00030,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00520,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R00765,R02035 RC00163,RC00537 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP10@1239,4HAG4@91061,COG0363@1,COG0363@2 NA|NA|NA G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion HLLCKODE_02133 322159.STER_0582 6.9e-213 746.5 Bacilli 2.7.13.3 ko:K07706 ko02020,ko02024,map02020,map02024 M00495 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1UDI2@1239,4HF65@91061,COG3290@1,COG3290@2 NA|NA|NA T signal transduction protein with a C-terminal ATPase domain HLLCKODE_02134 322159.STER_0583 1.3e-128 465.7 Bacilli rr02 Bacteria 1TXDF@1239,4HDA7@91061,COG3279@1,COG3279@2 NA|NA|NA KT response regulator HLLCKODE_02135 264199.stu0545 1.7e-114 418.7 Bacilli 2.7.7.73,2.7.7.80 ko:K03148,ko:K21029 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07459 RC00043 ko00000,ko00001,ko01000 Bacteria 1TQ3U@1239,4HBGP@91061,COG0476@1,COG0476@2 NA|NA|NA H Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 HLLCKODE_02136 264199.stu0545 5.7e-51 206.5 Bacilli 2.7.7.73,2.7.7.80 ko:K03148,ko:K21029 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07459 RC00043 ko00000,ko00001,ko01000 Bacteria 1TQ3U@1239,4HBGP@91061,COG0476@1,COG0476@2 NA|NA|NA H Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 HLLCKODE_02137 322159.STER_0586 4.8e-168 597.0 Bacilli ko:K01990,ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1UZK5@1239,4HB2Q@91061,COG1131@1,COG1131@2 NA|NA|NA V ABC transporter HLLCKODE_02138 264199.stu0547 5.4e-122 443.7 Bacilli sagI ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1USMY@1239,4HC3J@91061,COG1511@1,COG1511@2 NA|NA|NA S ABC-2 type transporter HLLCKODE_02139 1046629.Ssal_01622 6.9e-197 693.0 Bacilli yceA ko:K07146 ko00000 Bacteria 1TRG7@1239,4HA0J@91061,COG1054@1,COG1054@2 NA|NA|NA S Belongs to the UPF0176 family HLLCKODE_02140 1046629.Ssal_01621 1.6e-28 131.3 Bacilli XK27_00085 ko:K07729 ko00000,ko03000 Bacteria 1VERT@1239,4HNID@91061,COG1476@1,COG1476@2 NA|NA|NA K Transcriptional HLLCKODE_02141 706437.HMPREF0813_01845 2.3e-23 115.5 Streptococcus anginosus group Bacteria 1TVS7@1239,29ZMX@1,30MNF@2,42DTT@671232,4I418@91061 NA|NA|NA HLLCKODE_02142 264199.stu0551 9.1e-136 489.6 Bacilli deoD_1 2.4.2.3 ko:K00757 ko00240,ko00983,ko01100,map00240,map00983,map01100 R01876,R02484,R08229 RC00063 ko00000,ko00001,ko01000 Bacteria 1V6T2@1239,4HCSE@91061,COG2820@1,COG2820@2 NA|NA|NA F Phosphorylase superfamily HLLCKODE_02143 1046629.Ssal_01618 1.5e-113 415.6 Bacilli Bacteria 1V6KW@1239,4IPIC@91061,COG1814@1,COG1814@2 NA|NA|NA S VIT family HLLCKODE_02144 264199.stu0553 6.5e-128 463.4 Bacilli rsuA 5.4.99.19,5.4.99.22 ko:K06178,ko:K06183 ko00000,ko01000,ko03009 Bacteria 1TQZ2@1239,4H9VU@91061,COG1187@1,COG1187@2 NA|NA|NA J Belongs to the pseudouridine synthase RsuA family HLLCKODE_02145 1046629.Ssal_01616 5e-215 753.4 Bacilli hipO 3.5.1.47 ko:K01436,ko:K05823,ko:K21613 ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230 M00525 R02733 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000,ko01002 Bacteria 1TPD7@1239,4H9WQ@91061,COG1473@1,COG1473@2 NA|NA|NA E COG1473 Metal-dependent amidase aminoacylase carboxypeptidase HLLCKODE_02146 1046629.Ssal_01614 2.1e-197 694.9 Bacilli ald GO:0000286,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009653,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0019752,GO:0030154,GO:0030435,GO:0032502,GO:0043436,GO:0043934,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048646,GO:0048856,GO:0048869,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 R00396 RC00008 ko00000,ko00001,ko01000 iAF987.Gmet_1099 Bacteria 1TNZ5@1239,4HABX@91061,COG0686@1,COG0686@2 NA|NA|NA C Belongs to the AlaDH PNT family HLLCKODE_02148 1046629.Ssal_01611 1e-126 459.5 Firmicutes ko:K16264 ko00000,ko02000 2.A.4.1 Bacteria 1UUC7@1239,COG2021@1,COG2021@2 NA|NA|NA E Alpha beta hydrolase HLLCKODE_02149 435842.HMPREF0848_00188 6.3e-246 856.3 Bacilli merA GO:0000302,GO:0000305,GO:0001101,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016491,GO:0016667,GO:0019725,GO:0042221,GO:0042592,GO:0044424,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901530,GO:1901700,GO:1990748 1.16.1.1 ko:K00520,ko:K21739 ko00000,ko01000 Bacteria 1TP1W@1239,4HBZF@91061,COG1249@1,COG1249@2 NA|NA|NA C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family HLLCKODE_02150 904306.HMPREF9192_1284 1.8e-101 375.2 Bacilli GBS0088 ko:K09962 ko00000 Bacteria 1V1YD@1239,4HGK6@91061,COG3575@1,COG3575@2 NA|NA|NA J protein conserved in bacteria HLLCKODE_02151 904306.HMPREF9192_1285 8.5e-146 523.1 Bacilli mvk 1.1.1.88,2.3.3.10,2.7.1.36 ko:K00054,ko:K00869,ko:K01641 ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,ko04146,map00072,map00280,map00650,map00900,map01100,map01110,map01130,map04146 M00088,M00095 R01978,R02081,R02245 RC00002,RC00004,RC00017,RC00503,RC00644 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPVW@1239,4IRCB@91061,COG1577@1,COG1577@2 NA|NA|NA I mevalonate kinase HLLCKODE_02152 1046629.Ssal_01607 1.2e-169 602.4 Bacilli mvaD 4.1.1.33 ko:K01597 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00095 R01121 RC00453 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQXR@1239,4HAM6@91061,COG3407@1,COG3407@2 NA|NA|NA I diphosphomevalonate decarboxylase HLLCKODE_02153 1046629.Ssal_01606 5.1e-163 580.5 Bacilli mvaK2 2.7.1.36,2.7.1.43,2.7.4.2 ko:K00869,ko:K00938,ko:K16190 ko00040,ko00053,ko00520,ko00900,ko01100,ko01110,ko01130,ko04146,map00040,map00053,map00520,map00900,map01100,map01110,map01130,map04146 M00014,M00095 R01476,R02245,R03245 RC00002,RC00017,RC00078 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPKP@1239,4HWXG@91061,COG1577@1,COG1577@2 NA|NA|NA I phosphomevalonate kinase HLLCKODE_02154 1046629.Ssal_01605 2.4e-184 651.4 Bacilli fni 1.1.1.88,5.3.3.2 ko:K00054,ko:K01823 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00095,M00096,M00364,M00365,M00366,M00367 R01123,R02081 RC00004,RC00455,RC00644 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQZ3@1239,4HAMV@91061,COG1304@1,COG1304@2 NA|NA|NA C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) HLLCKODE_02155 435842.HMPREF0848_00193 0.0 1673.3 Bacilli mgtA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0015399,GO:0015405,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0099131,GO:0099132 3.6.3.2 ko:K01531 ko00000,ko01000 3.A.3.4 iSF_1195.SF4248 Bacteria 1TPF5@1239,4HBQJ@91061,COG0474@1,COG0474@2 NA|NA|NA P COG0474 Cation transport ATPase HLLCKODE_02156 1046629.Ssal_01601 1.1e-227 795.8 Bacilli glmU GO:0000270,GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006629,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009252,GO:0009273,GO:0009987,GO:0016051,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030203,GO:0030260,GO:0033692,GO:0034637,GO:0034645,GO:0035635,GO:0040007,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903509 2.3.1.157,2.7.7.23 ko:K04042,ko:K11528 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP88@1239,4H9V5@91061,COG1207@1,COG1207@2 NA|NA|NA M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain HLLCKODE_02157 1046629.Ssal_01599 6.5e-96 356.7 Bacilli nudF 3.6.1.13 ko:K01515 ko00230,map00230 R01054 RC00002 ko00000,ko00001,ko01000 iHN637.CLJU_RS05505,iSB619.SA_RS07540,iYO844.BSU23610 Bacteria 1V6F5@1239,4HII9@91061,COG0494@1,COG0494@2 NA|NA|NA L AdP-ribose pyrophosphatase HLLCKODE_02158 1046629.Ssal_01598 7.3e-21 106.3 Bacilli Bacteria 1W5SW@1239,2DC3Q@1,2ZCSA@2,4I23E@91061 NA|NA|NA HLLCKODE_02159 904306.HMPREF9192_1295 2.2e-117 428.3 Bacilli mtnN 3.2.2.9 ko:K01243 ko00270,ko01100,ko01230,map00270,map01100,map01230 M00034,M00609 R00194,R01401 RC00063,RC00318 ko00000,ko00001,ko00002,ko01000 Bacteria 1U7WK@1239,4HB8K@91061,COG0775@1,COG0775@2 NA|NA|NA E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively HLLCKODE_02160 1046629.Ssal_01596 0.0 1426.4 Bacteria ko:K02460 ko03070,ko05111,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02044 3.A.15 Bacteria COG3156@1,COG3156@2,COG4932@1,COG4932@2 NA|NA|NA U protein secretion HLLCKODE_02161 1046629.Ssal_01595 9.8e-191 672.5 Bacilli dgs 2.4.1.208 ko:K13677 ko00561,ko01100,map00561,map01100 R05164 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003 GT4 Bacteria 1TPSS@1239,4HBKA@91061,COG0438@1,COG0438@2 NA|NA|NA M Glycosyltransferase, group 1 family protein HLLCKODE_02162 1046629.Ssal_01594 4.5e-244 850.1 Bacilli mgs GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006629,GO:0006643,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046872,GO:0071704,GO:1901576 2.4.1.337 ko:K19002 ko00561,ko01100,map00561,map01100 R10850 RC00005,RC00059 ko00000,ko00001,ko01000,ko01003 GT4 Bacteria 1TPTA@1239,4HA41@91061,COG0438@1,COG0438@2 NA|NA|NA M Glycosyltransferase, group 1 family protein HLLCKODE_02163 889204.HMPREF9423_1244 4e-53 213.8 Bacilli XK27_13030 Bacteria 1VBNS@1239,2DMJF@1,32RYX@2,4HMXU@91061 NA|NA|NA HLLCKODE_02164 1046629.Ssal_01592 0.0 1283.1 Bacilli thrS GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1TP78@1239,4HABZ@91061,COG0441@1,COG0441@2 NA|NA|NA J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) HLLCKODE_02165 1046629.Ssal_01591 1.3e-144 519.2 Bacilli Bacteria 1V202@1239,4HJ0U@91061,COG0596@1,COG0596@2 NA|NA|NA S hydrolases or acyltransferases (alpha beta hydrolase superfamily) HLLCKODE_02166 904306.HMPREF9192_1302 2.6e-194 684.5 Bacilli Bacteria 1VFZ3@1239,2DQ82@1,3357U@2,4HNXV@91061 NA|NA|NA S Protein of unknown function (DUF3114) HLLCKODE_02167 1046629.Ssal_01589 4.1e-29 133.3 Bacilli pspC Bacteria 1VKBQ@1239,4HRGW@91061,COG1983@1,COG1983@2 NA|NA|NA KT PspC domain protein HLLCKODE_02168 435842.HMPREF0848_00209 4.4e-118 430.6 Bacilli yqfA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K11068 ko00000,ko02042 Bacteria 1TTA5@1239,4HDYT@91061,COG1272@1,COG1272@2 NA|NA|NA K protein, Hemolysin III HLLCKODE_02169 1046629.Ssal_01586 5e-78 297.0 Firmicutes ko:K11068 ko00000,ko02042 Bacteria 1V7Z4@1239,COG0789@1,COG0789@2 NA|NA|NA K hmm pf08876 HLLCKODE_02170 1046629.Ssal_01585 2.5e-223 781.2 Bacilli mvaA 1.1.1.34,1.1.1.88,2.3.1.9 ko:K00021,ko:K00054,ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,ko04152,ko04976,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020,map04152,map04976 M00088,M00095,M00373,M00374,M00375 R00238,R01177,R02081,R02082 RC00004,RC00326,RC00644 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1TPNY@1239,4HBQ3@91061,COG1257@1,COG1257@2 NA|NA|NA C Belongs to the HMG-CoA reductase family HLLCKODE_02171 1046629.Ssal_01584 1e-210 739.2 Bacilli mvaS 2.3.3.10 ko:K01641 ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130 M00088,M00095 R01978 RC00004,RC00503 ko00000,ko00001,ko00002,ko01000 Bacteria 1TR4K@1239,4HA67@91061,COG3425@1,COG3425@2 NA|NA|NA I synthase HLLCKODE_02172 1046629.Ssal_01582 2.1e-165 588.2 Bacilli thyA 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 Bacteria 1TSIR@1239,4HI1C@91061,COG0207@1,COG0207@2 NA|NA|NA F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis HLLCKODE_02173 904306.HMPREF9192_1309 1.9e-89 335.1 Bacilli folA 1.5.1.3,1.5.1.47,2.1.1.45,3.5.4.12 ko:K00287,ko:K00560,ko:K01493,ko:K05896,ko:K17364 ko00240,ko00670,ko00790,ko01100,ko01523,map00240,map00670,map00790,map01100,map01523 M00053,M00126,M00429,M00840 R00936,R00937,R00939,R00940,R01663,R02101,R02235,R02236,R03388,R11765 RC00074,RC00109,RC00110,RC00158,RC00219,RC00332,RC01584 ko00000,ko00001,ko00002,ko01000,ko02044,ko03036 Bacteria 1VB80@1239,4HIGJ@91061,COG0262@1,COG0262@2 NA|NA|NA H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis HLLCKODE_02174 435842.HMPREF0848_00215 9.7e-22 108.6 Bacilli Bacteria 1W5G0@1239,2DFKW@1,2ZS8U@2,4HZFD@91061 NA|NA|NA HLLCKODE_02175 1046629.Ssal_01579 2.6e-225 787.7 Bacilli clpX GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030312,GO:0030554,GO:0031333,GO:0031597,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0043335,GO:0044087,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0051704,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 ko:K03544 ko04112,map04112 ko00000,ko00001,ko03110 Bacteria 1TQ00@1239,4H9U4@91061,COG1219@1,COG1219@2 NA|NA|NA O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP HLLCKODE_02176 1046629.Ssal_01578 3.9e-110 404.1 Bacilli engB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:0097367,GO:1901265,GO:1901363 ko:K03978 ko00000,ko03036 Bacteria 1TSPW@1239,4HBXZ@91061,COG0218@1,COG0218@2 NA|NA|NA D Necessary for normal cell division and for the maintenance of normal septation HLLCKODE_02177 1046629.Ssal_01577 1.8e-15 87.4 Firmicutes mmuP GO:0000096,GO:0000097,GO:0000100,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0006810,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0015806,GO:0016020,GO:0016053,GO:0019752,GO:0022857,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0072337,GO:0072348,GO:0072349,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901682 ko:K02205,ko:K03293,ko:K16235,ko:K16236 ko00000,ko02000 2.A.3.1,2.A.3.1.10 Bacteria 1UHNR@1239,COG0833@1,COG0833@2 NA|NA|NA E amino acid HLLCKODE_02178 1046629.Ssal_01577 4.3e-217 760.4 Firmicutes mmuP GO:0000096,GO:0000097,GO:0000100,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0006810,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0015806,GO:0016020,GO:0016053,GO:0019752,GO:0022857,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0072337,GO:0072348,GO:0072349,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901682 ko:K02205,ko:K03293,ko:K16235,ko:K16236 ko00000,ko02000 2.A.3.1,2.A.3.1.10 Bacteria 1UHNR@1239,COG0833@1,COG0833@2 NA|NA|NA E amino acid HLLCKODE_02179 1046629.Ssal_01576 5.5e-167 593.6 Bacilli mmuM GO:0003674,GO:0003824,GO:0005488,GO:0006575,GO:0006790,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008270,GO:0008757,GO:0008898,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0033477,GO:0033554,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:1901564 1.5.1.20,2.1.1.10 ko:K00297,ko:K00547 ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523 M00377 R00650,R01224,R07168 RC00003,RC00035,RC00081 ko00000,ko00001,ko00002,ko01000 Bacteria 1UHQ5@1239,4HAS6@91061,COG2040@1,COG2040@2 NA|NA|NA H Homocysteine HLLCKODE_02180 1035184.HMPREF1042_0385 2.2e-30 137.9 Streptococcus anginosus group Bacteria 1VYRT@1239,2BXCI@1,346RD@2,42DR8@671232,4HYPP@91061 NA|NA|NA S Domain of unknown function (DUF1912) HLLCKODE_02181 759913.SDSE_1678 4e-12 77.8 Streptococcus dysgalactiae group Bacteria 1M9TG@119603,1TXCP@1239,2DJ7H@1,304X7@2,4I6AH@91061 NA|NA|NA L Helix-hairpin-helix DNA-binding motif class 1 HLLCKODE_02182 1046629.Ssal_01573 1.9e-107 395.2 Bacilli plsY GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.3.1.15,3.5.1.104 ko:K08591,ko:K22278 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 1VA3J@1239,4HC55@91061,COG0344@1,COG0344@2 NA|NA|NA I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP HLLCKODE_02183 1046629.Ssal_01572 0.0 1221.8 Bacilli parE GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0034335,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 5.99.1.3 ko:K02470,ko:K02622 ko00000,ko01000,ko02048,ko03032,ko03036,ko03400 Bacteria 1TQCF@1239,4H9UC@91061,COG0187@1,COG0187@2 NA|NA|NA L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule HLLCKODE_02185 889204.HMPREF9423_1044 1e-08 67.0 Streptococcus infantis Bacteria 1UQEG@1239,2BAK8@1,32411@2,43FF9@68892,4I578@91061 NA|NA|NA HLLCKODE_02186 904306.HMPREF9192_1319 0.0 1565.1 Bacilli parC GO:0005575,GO:0005622,GO:0005623,GO:0009330,GO:0032991,GO:0044424,GO:0044464 5.99.1.3 ko:K02469,ko:K02621 ko00000,ko01000,ko02048,ko03032,ko03036,ko03400 Bacteria 1TRE7@1239,4HAQB@91061,COG0188@1,COG0188@2 NA|NA|NA L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule HLLCKODE_02187 1046629.Ssal_01567 2.4e-200 704.5 Bacilli ilvE 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 1TQQI@1239,4HASX@91061,COG0115@1,COG0115@2 NA|NA|NA E Aminotransferase HLLCKODE_02188 1035187.HMPREF9959_0525 3.7e-16 90.5 Streptococcus mitis Bacteria 1U4J6@1239,29N96@1,2TPZ6@28037,30971@2,4IEAX@91061 NA|NA|NA S Protein of unknown function (DUF2969) HLLCKODE_02191 1046629.Ssal_01564 2.5e-204 718.0 Bacilli rpsA 1.17.7.4 ko:K02945,ko:K03527 ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010 M00096,M00178 R05884,R08210 RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 Bacteria 1TQ9N@1239,4H9PX@91061,COG0539@1,COG0539@2 NA|NA|NA J ribosomal protein S1 HLLCKODE_02192 1069533.Sinf_0020 9.5e-21 105.5 Firmicutes Bacteria 1TQ93@1239,COG3464@1,COG3464@2 NA|NA|NA L Transposase HLLCKODE_02194 904294.HMPREF9182_1299 3.4e-43 181.0 Firmicutes ko:K07483 ko00000 Bacteria 1VDX9@1239,COG2963@1,COG2963@2 NA|NA|NA L Transposase HLLCKODE_02195 388919.SSA_0265 8.2e-22 109.0 Streptococcus sanguinis ko:K07483 ko00000 Bacteria 1W68S@1239,1WS1X@1305,4I47X@91061,COG2963@1,COG2963@2 NA|NA|NA L IS861 transposase HLLCKODE_02196 1316408.HSISM1_1539 1.9e-126 458.8 Bacilli ko:K07497 ko00000 Bacteria 1TQQY@1239,4HC8M@91061,COG2801@1,COG2801@2 NA|NA|NA L Transposase and inactivated derivatives HLLCKODE_02197 904294.HMPREF9182_1249 3.9e-202 710.7 Bacilli Bacteria 1TQ5G@1239,4IPIE@91061,COG3547@1,COG3547@2 NA|NA|NA L Transposase IS116 IS110 IS902 HLLCKODE_02198 1282664.H354_05021 0.0 1557.3 Bacilli XK27_00500 Bacteria 1TPQA@1239,4HDHN@91061,COG0553@1,COG0553@2,COG0827@1,COG0827@2,COG4646@1,COG4646@2 NA|NA|NA L the current gene model (or a revised gene model) may contain a HLLCKODE_02199 1280688.AUJB01000002_gene2087 5e-16 91.7 Firmicutes Bacteria 1V9GR@1239,COG3550@1,COG3550@2 NA|NA|NA S HipA-like C-terminal domain HLLCKODE_02201 330397.A8ATM0_9CAUD 1.4e-58 234.2 Siphoviridae Viruses 4QBV2@10239,4QMBW@10699,4QQUQ@28883,4QW78@35237 NA|NA|NA S PcfJ-like protein HLLCKODE_02202 272626.lin1252 1.8e-12 79.3 Bacilli Bacteria 1VJEJ@1239,2E67P@1,330W5@2,4HQDJ@91061 NA|NA|NA S PcfK-like protein HLLCKODE_02203 1123298.KB904071_gene1133 2.3e-38 166.0 Bacilli comGA ko:K02243 M00429 ko00000,ko00002,ko02044 3.A.14.1 Bacteria 1TPGE@1239,4HB0C@91061,COG2804@1,COG2804@2 NA|NA|NA NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB HLLCKODE_02204 999411.HMPREF1092_03225 3.3e-17 96.7 Clostridia Bacteria 1VSR7@1239,24S9A@186801,2EYQW@1,33RY9@2 NA|NA|NA HLLCKODE_02205 996306.SSUR61_0081 1.1e-72 279.6 Streptococcus suis Bacteria 1U8YB@1239,1WSV0@1307,28JJY@1,2Z9CV@2,4IIXR@91061 NA|NA|NA S Region found in RelA / SpoT proteins HLLCKODE_02206 1396.DJ87_5458 4.9e-28 132.5 Bacillus dnaG ko:K02316 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Bacteria 1TZWY@1239,1ZMDD@1386,4I96C@91061,COG0358@1,COG0358@2 NA|NA|NA L DNA primase activity HLLCKODE_02207 1229756.C269_07800 5.4e-25 121.7 Leuconostocaceae soj ko:K03496 ko00000,ko03036,ko04812 Bacteria 1TP8S@1239,4AX2I@81850,4HAYM@91061,COG1192@1,COG1192@2 NA|NA|NA D ATPases involved in chromosome partitioning HLLCKODE_02209 546275.FUSPEROL_00031 8e-08 65.5 Fusobacteria Bacteria 37AAT@32066,COG5527@1,COG5527@2 NA|NA|NA L Psort location Cytoplasmic, score 8.96 HLLCKODE_02210 568703.LGG_01425 5.6e-21 108.6 Lactobacillaceae xerS GO:0000150,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009987,GO:0015074,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140097,GO:1901360 ko:K04763 ko00000,ko03036 Bacteria 1URNQ@1239,3FBHV@33958,4HEPI@91061,COG4974@1,COG4974@2 NA|NA|NA L Belongs to the 'phage' integrase family HLLCKODE_02211 1005705.HMPREF9967_0844 5.6e-52 211.5 Bacilli spd ko:K15051 ko00000 Bacteria 1TR37@1239,4HK9Z@91061,COG2169@1,COG2169@2 NA|NA|NA F DNA RNA non-specific endonuclease HLLCKODE_02213 435842.HMPREF0848_00167 1.7e-230 805.1 Bacilli 2.7.13.3 ko:K07706 ko02020,ko02024,map02020,map02024 M00495 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1UYTM@1239,4HKY4@91061,COG3290@1,COG3290@2 NA|NA|NA T GHKL domain HLLCKODE_02214 435842.HMPREF0848_00168 5.3e-133 480.3 Bacilli agrA ko:K07707 ko02020,ko02024,map02020,map02024 M00495 ko00000,ko00001,ko00002,ko02022 Bacteria 1V392@1239,4HHAI@91061,COG3279@1,COG3279@2 NA|NA|NA KT Response regulator of the LytR AlgR family HLLCKODE_02217 482234.SCAZ3_03395 2.5e-96 358.2 Bacilli Bacteria 1TQ5G@1239,4IPIF@91061,COG3547@1,COG3547@2 NA|NA|NA L Transposase and inactivated derivatives HLLCKODE_02218 1154860.SAG0136_09800 1e-37 162.5 Bacilli Bacteria 1TQ5G@1239,4IPIF@91061,COG3547@1,COG3547@2 NA|NA|NA L Transposase and inactivated derivatives HLLCKODE_02219 210007.SMU_1301c 6.9e-104 383.6 Bacilli ubiE Bacteria 1TSVN@1239,4HBRU@91061,COG0500@1,COG2226@2 NA|NA|NA Q Methyltransferase HLLCKODE_02220 888816.HMPREF9389_0702 3.7e-20 106.3 Streptococcus sanguinis Bacteria 1UABH@1239,1WS3H@1305,29RPN@1,30CT3@2,4IKPN@91061 NA|NA|NA S Ribosomal protein S1-like RNA-binding domain HLLCKODE_02222 388919.SSA_0152 2.7e-127 463.4 Streptococcus sanguinis Bacteria 1V0JC@1239,1WS19@1305,4HAST@91061,COG3505@1,COG3505@2 NA|NA|NA U TraM recognition site of TraD and TraG HLLCKODE_02223 1046629.Ssal_01665 4.8e-97 360.5 Bacilli ko:K07023 ko00000 Bacteria 1V3MK@1239,4HK4Q@91061,COG1896@1,COG1896@2 NA|NA|NA S HD domain HLLCKODE_02230 563038.HMPREF0851_01445 4.8e-172 612.1 Bacilli Bacteria 1VSRF@1239,2EWZS@1,33QB2@2,4HVAW@91061 NA|NA|NA S there are four paralogs in L.lactis HLLCKODE_02231 563038.HMPREF0851_01447 3.4e-46 191.4 Bacilli Bacteria 1W3A8@1239,2DEIC@1,2ZN3X@2,4HZMP@91061 NA|NA|NA HLLCKODE_02233 888746.HMPREF9180_1120 2.7e-99 368.6 Firmicutes Bacteria 1V0UD@1239,28I8E@1,2Z8B8@2 NA|NA|NA HLLCKODE_02234 1473546.CH76_03715 2.7e-15 90.1 Bacilli Bacteria 1TQKT@1239,4HDNU@91061,COG0675@1,COG0675@2 NA|NA|NA L Transposase, IS605 OrfB family HLLCKODE_02238 1123303.AQVD01000004_gene224 1.4e-32 146.0 Bacilli ssb ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 ko00000,ko00001,ko03029,ko03032,ko03400 Bacteria 1V3WT@1239,4HH8I@91061,COG0629@1,COG0629@2 NA|NA|NA L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism HLLCKODE_02239 1069533.Sinf_0777 1.1e-65 256.9 Bacilli pi112 3.6.4.12 ko:K03657,ko:K16898 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 1V1UQ@1239,4HGSG@91061,COG1074@1,COG1074@2 NA|NA|NA L PDDEXK-like domain of unknown function (DUF3799) HLLCKODE_02240 1209989.TepiRe1_1126 1.3e-09 70.9 Thermoanaerobacterales Bacteria 1VC16@1239,24RAH@186801,2C9JF@1,32RPD@2,42IR8@68295 NA|NA|NA S ERF superfamily HLLCKODE_02245 873447.SPB_0482 1.3e-29 136.7 Bacilli radC ko:K03630 ko00000 Bacteria 1TQ3K@1239,4HB1W@91061,COG2003@1,COG2003@2 NA|NA|NA E Belongs to the UPF0758 family HLLCKODE_02253 264199.stu1509 3.5e-103 380.9 Bacilli abiGI Bacteria 1V3JU@1239,4HMVW@91061,COG5340@1,COG5340@2 NA|NA|NA K Transcriptional regulator, AbiEi antitoxin HLLCKODE_02255 999425.HMPREF9186_01890 1.9e-81 308.5 Bacilli FNV0100 Bacteria 1V4ND@1239,4HJ5H@91061,COG1051@1,COG1051@2 NA|NA|NA F Belongs to the Nudix hydrolase family HLLCKODE_02256 1419814.V470_05610 4.5e-71 273.9 Bacilli XK27_01300 Bacteria 1V6S0@1239,4HKKR@91061,COG4405@1,COG4405@2 NA|NA|NA P Protein conserved in bacteria HLLCKODE_02259 1116231.SMA_1384 1.3e-196 692.6 Bacilli Bacteria 1TS12@1239,4HEKK@91061,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor HLLCKODE_02260 904306.HMPREF9192_0194 2.2e-125 454.9 Bacilli Bacteria 1TYPK@1239,4HBUE@91061,COG0745@1,COG0745@2 NA|NA|NA T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain HLLCKODE_02261 904306.HMPREF9192_0193 6.9e-167 593.2 Bacilli bcrA ko:K20459 ko02010,map02010 M00813 ko00000,ko00001,ko00002,ko02000 3.A.1.124.3,3.A.1.124.4,3.A.1.124.5 Bacteria 1TP4J@1239,4HBGH@91061,COG1131@1,COG1131@2 NA|NA|NA V abc transporter atp-binding protein HLLCKODE_02262 904306.HMPREF9192_0192 1.1e-130 472.6 Bacilli ko:K20460,ko:K20461 ko02010,map02010 M00813 ko00000,ko00001,ko00002,ko02000 3.A.1.124.3,3.A.1.124.4,3.A.1.124.5 Bacteria 1V5VS@1239,4HH7H@91061,COG4200@1,COG4200@2 NA|NA|NA S ABC-2 family transporter protein HLLCKODE_02263 904306.HMPREF9192_0191 1.5e-124 452.2 Bacilli ko:K20461 ko02010,map02010 M00813 ko00000,ko00001,ko00002,ko02000 3.A.1.124.3,3.A.1.124.4,3.A.1.124.5 Bacteria 1V3PM@1239,4HHIJ@91061,COG4200@1,COG4200@2 NA|NA|NA S ABC-2 family transporter protein HLLCKODE_02264 904306.HMPREF9192_0189 1.1e-62 245.7 Bacteria Bacteria COG3942@1,COG3942@2 NA|NA|NA S pathogenesis HLLCKODE_02266 1095726.HMPREF1116_1850 1.4e-75 288.9 Bacilli mutT 3.6.1.13,3.6.1.55,3.6.1.56,3.6.1.62,3.6.1.64 ko:K01515,ko:K03574,ko:K16855,ko:K17816 ko00230,ko03018,map00230,map03018 R00961,R01054,R10235,R10815 RC00002 ko00000,ko00001,ko01000,ko03019,ko03400 Bacteria 1V6SS@1239,4HM6E@91061,COG1051@1,COG1051@2 NA|NA|NA F Nudix family HLLCKODE_02267 866776.HMPREF9321_1601 2.6e-117 427.9 Negativicutes Bacteria 1TSHF@1239,4H3W6@909932,COG2207@1,COG2207@2 NA|NA|NA K Psort location Cytoplasmic, score HLLCKODE_02268 365659.smi_1780 1.3e-218 765.4 Streptococcus mitis ko:K07133 ko00000 Bacteria 1TP7X@1239,2TNQT@28037,4HCSJ@91061,COG1373@1,COG1373@2 NA|NA|NA S AAA domain HLLCKODE_02269 873449.STRCR_1719 8.9e-10 70.5 Firmicutes Bacteria 1W52H@1239,2DZ54@1,34CFU@2 NA|NA|NA S Protein of unknown function (DUF2975) HLLCKODE_02270 888821.HMPREF9394_1001 3.3e-22 110.5 Bacilli yozG ko:K07727 ko00000,ko03000 Bacteria 1VESP@1239,4HKR7@91061,COG3655@1,COG3655@2 NA|NA|NA K Transcriptional regulator HLLCKODE_02271 996306.SSUR61_2334 7.2e-08 63.9 Streptococcus suis Bacteria 1U97D@1239,1WU00@1307,29R3X@1,30C54@2,4IJ9T@91061 NA|NA|NA HLLCKODE_02273 1069533.Sinf_0131 3.2e-145 521.2 Bacilli Bacteria 1TQEG@1239,4HD6M@91061,COG2801@1,COG2801@2 NA|NA|NA L Integrase core domain protein HLLCKODE_02274 1069533.Sinf_0130 1.6e-123 448.7 Bacilli ko:K07483 ko00000 Bacteria 1V1QC@1239,4HH7E@91061,COG2963@1,COG2963@2 NA|NA|NA L Helix-turn-helix domain HLLCKODE_02277 888821.HMPREF9394_1137 6.2e-85 320.1 Streptococcus sanguinis MA20_25245 Bacteria 1VEEJ@1239,1WQGU@1305,4HP6M@91061,COG0454@1,COG0456@2 NA|NA|NA K Acetyltransferase (GNAT) domain HLLCKODE_02278 388919.SSA_0154 1.8e-44 186.8 Streptococcus sanguinis Bacteria 1UACA@1239,1WS50@1305,2BJS4@1,32E46@2,4IKQI@91061 NA|NA|NA HLLCKODE_02281 388919.SSA_0156 2.2e-130 473.0 Streptococcus sanguinis clpB ko:K03694,ko:K03695,ko:K03696 ko01100,ko04213,map01100,map04213 ko00000,ko00001,ko03110 Bacteria 1TPMU@1239,1WS1P@1305,4HACY@91061,COG0542@1,COG0542@2 NA|NA|NA O C-terminal, D2-small domain, of ClpB protein HLLCKODE_02283 388919.SSA_0158 5.2e-45 188.7 Streptococcus sanguinis Bacteria 1UAAE@1239,1WS13@1305,29RP1@1,30CSB@2,4IKMZ@91061 NA|NA|NA HLLCKODE_02284 888816.HMPREF9389_0711 9.6e-53 215.3 Streptococcus sanguinis Bacteria 1UAB6@1239,1WS2W@1305,4IKP9@91061,COG4487@1,COG4487@2 NA|NA|NA I mechanosensitive ion channel activity HLLCKODE_02285 435842.HMPREF0848_00079 9.8e-161 572.8 Bacteria ko:K20342,ko:K20480 ko02024,map02024 ko00000,ko00001,ko03000 Bacteria COG1396@1,COG1396@2 NA|NA|NA K sequence-specific DNA binding HLLCKODE_02286 889201.HMPREF9422_1357 7.7e-09 67.8 Bacilli Bacteria 1W1N9@1239,2DFHB@1,2ZRUI@2,4I1TG@91061 NA|NA|NA # 1978 queries scanned # Total time (seconds): 5.02323484421 # Rate: 393.77 q/s