LOCUS       c00005_JADNKM0..       13479 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JADNKM010000014.1 Streptococcus salivarius strain D6t1_180914_F9
            NODE_14_length_58459_cov_31.3193, whole genome shotgun sequence.
ACCESSION   JADNKM010000014
VERSION     JADNKM010000014
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2022-06-20 18:10:50
            Original ID  :: JADNKM010000014.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 44980
            Orig. end    :: 58459
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13479
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[54980:58247]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13267
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..13479
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13479
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(2148..5729)
                     /locus_tag="ctg5_55"
                     /transl_table=11
                     /translation="LAGHDVQYGKHRTRRSFSRIKEVLDLPNLIEIQTDSFKEFLDTGL
                     KEVFEDVLPISNFTDTMELEFVGYELKEPKYTLEEARIHDASYSAPIFVTFRLINKETG
                     EIKTQEVFFGDFPIMTEMGTFIINGGERIIVSQLVRSPGVYFNDKVDKNGKVGYGSTVI
                     PNRGAWLELETDSKDIAYTRIDRTRKIPFTTLVRALGFSGDDEIVDIFGDSELVRNTIE
                     KDIHKNPADSRTDEALKEIYERLRPGEPKTADSSRSLLVARFFDPRRYDLAAVGRYKVN
                     KKLNIKTRLLGQTIAENLVDPETGEILVEAGTEMTRDVIDSIAEYLDGDLNKFVYTPND
                     YAVVTEPVVLQKFKVVAPNDPDRVVTIVGNANPDDKVRALTTADILAEMSYFLNLAEGI
                     GKVDDIDHLGNRRIRAVGELLANQFRIGLARMERNVRERMSVQDNEVLTPQQIINIRPV
                     TAAVKEFFGSSQLSQFMDQHNPLSELSHKRRLSALGPGGLTRDRAGYEVRDVHYTHYGR
                     MCPIETPEGPNIGLINNLSSYGHLNKYGFIQTPYRKVDRATGKVTNEVVWLTADEEDEY
                     TVAQANSKLNEDGTFAEEIVMGRHQGNNQEYPSHLVDFVDVSPKQVVAVATACIPFLEN
                     DDSNRALMGANMQRQAVPLIDPKAPYVGTGMEYQAAHDSGAAVIAQHDGKVVYSDADKV
                     EVRREDGSLDVYTIQKFRRSNSGTAYNQRTLVKVGDIVEKGDFIADGPSMEGGEMALGQ
                     NPIVAYMTWEGYNFEDAVIMSERLVKDDVYTSVHLEEFESETRDTKLGPEEITRELPNV
                     GEEALKDLDEMGIIRIGAEVKEGDILVGKVTPKGEKDLSAEERLLHAIFGDKSREVRDT
                     SLRVPHGGDGVVRDVKIFTRANGDELQSGVNMLVRVYIAQKRKIKVGDKMAGRHGNKGV
                     VSRIVPVEDMPYLPDGTPVDIMLNPLGVPSRMNIGQVMELHLGMAARNLGIHIATPVFD
                     GASSEDLWDTVREAGMDSDAKTILYDGRTGEPFDNRVSVGVMYMIKLHHMVDDKLHARS
                     VGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGASNILQEILTYKSDDVNGRLKAYE
                     AITKGKPIPKPGVPESFRVLVKELQSLGLDMRVLDEDDYEVELRDLDEGEDDDVMHVDD
                     LEKARVQQAKEAAELEKAKEEASDKTE"
     CDS             complement(6088..8343)
                     /locus_tag="ctg5_56"
                     /transl_table=11
                     /translation="MTLLDMGDVFLKTLKLLSDFFYVVIIVLTLFGAGIGLGYLGSQIE
                     TVPSIKDKTLLNQISEVSLVSSMSYSDSKKIADIDTDLLRTPIESDAISNNVKNAIIAT
                     EDENFKKHKGVVPKAVFRALVSSVLGVGSSSGGSTLTQQLIKQQVTGDAPTFKRKAAEI
                     IYALQLERRVSKNEILTDYLNVSPFGRNNKGKNIAGIEEAAQGIFGVSAADLTVPQAAY
                     LAGLPQSPIVYSPYTADGQLKNAEDLSYGLARQQDVLYNLYRGGYLDKSQYESYKNYDI
                     TKDFKAGEKSDAVSHDYLYYSVMSEAQGVMYDYLVKHDKVSSQELKNDKTKESYRERAL
                     QELQTGGYSVKTTIDNAVYNAMQDAASQYGGLLDQGGNSGVEVGNVLMDNATGAILGFV
                     GGRSYENNQNNHAFDTARSPGSSIKPIIAYGIAIDQGLMGSSSILSNYPTNFTGGTPIL
                     HDGDKGTAMMNLQEALNTSWNIPAFWTYQMLQRHDVDVEGYMTKMGYKIANYNIESLPL
                     GGGIETTVAQQVNAYQMLSNGGVYEKGHMIDSITDRTGEVIYQHKSEGVQVFSRATASI
                     MDNLLKEVVVKGATTQFHSELKNVNGAAASADWMGKTGTTDNFADAWLIVSTPGITLGG
                     WAGYDNNTPTNSKTGYIYNSQYMARLTSAIYNANPGIFKTGDKFNIDSSAIKASVLKST
                     GLKPATVSVNGRNVSVSGEMVDTYWAKNGPGDTTYKFAIGGTDSDYQKAWSSILGGH"
     CDS             8613..9869
                     /locus_tag="ctg5_57"
                     /transl_table=11
                     /translation="MTIFEELKARGLIFQTTDEEALVKAFEEGPVSYYTGYDPTADSLH
                     LGHLVAILTSRRLQLAGHKPYALVGGATGLIGDPSFKDAERSLQTKETVEGWVEKIQGQ
                     LSRFLDFENGDNKAVMVNNYDWFGSVSFIDFLRDVGKYFTVNYMMSKESVKKRIETGIS
                     YTEFAYQIMQGYDFYELNDKYGVTLQIGGSDQWGNMTAGTELLRRKADKSGHVITVPLI
                     TDSTGKKFGKSEGNAVWLDATKTTPYEMYQFWLNVMDDDAVRFLKIFTFLSLEEIEEIG
                     KEFDQARHQRLAQKVLAREVVTLVHGKDAYEQAVHITEQLFAGNLKALSARDLKVALNG
                     VPTYEISGDENLNIVELLVNAKISPSKRQAREDVQNGAIYINGERVQDLDYTLSDADKI
                     DNEITVIRRGKKKNFVLTY"
     CDS             complement(10001..11023)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_58"
                     /sec_met_domain="IlvN (E-value: 5.8e-80, bitscore: 258.6,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 1.1e-62, bitscore: 202.6,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVQMEYEKDVKVAALDGKKIAVIGYGSQGHAHAQNLRDSGHDVI
                     IGVRPGKSFDKAKEDGFDTYTVAEATKLADIIMVLAPDEIQKDIYKDEIEPNLSAGKAL
                     GFAHGFNIHFEFIKVPKDVDVFMVAPKGPGHLVRRTYTEGFGVPALYAVYQDATGNAKD
                     IAMDWAKGIGSARVGLLVTTFKEETEEDLFGEQAVLMGGLTHLIEAGFEVLTEAGYAPQ
                     LAYFEVLHEMKLIVDLIYEGGFKKMRQSCSNTAEFGDFVTGPRVIGPEVKENMKAALAD
                     IQSGKFAREFVEDHDAGFPRLKAYRKEAEELEIEKIGAELRKAMPFVGQNDDDAFKIYN
                     "
     CDS             complement(11098..11574)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_59"
                     /sec_met_domain="ALS_ss_C (E-value: 2.1e-28, bitscore:
                     90.4, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRMLTAKLQNRSGVLNRFTGVLSRRQVNIESISVGASEDPNVSR
                     ITIIIDVNSQNEVEQIIKQLNRQIDVIRIRDITDQPHLEREVILVKVSAPTSKRAEILA
                     IIQPFRASVVDVAPSSITIQMTGDAEKSEALLRVIRPYGIKNIARTGATGFTRD"
     CDS             complement(11567..13267)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_60"
                     /sec_met_domain="TPP_enzyme_C (E-value: 6.8e-48, bitscore:
                     154.3, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VKKIELEEARSGADLILDTLLELGISTIFGYPGGAVLPLYDAIYK
                     NDKINHILSRHEQGSLHEAEGYAKSTGKLGVALVTSGPGATNAITGIADAMSDSVPLLV
                     FTGQVATSGIGKDAFQEADIVGITMPITKYNYQIRDTADIPRIIREAVHIATTGRPGPV
                     VIDLPKDVVAKETAFINDPEINLPSYQPTLRPNEMQIKKILKQLGKAKKPVIVAGGGVS
                     YSESAKELVAFAERYQIPVVTSLLGQGTIATSHPLFLGMGGMHGSYAANIAMTDADFMI
                     AIGCRFDDRLTGNPKTFAKNAKVVHIDVDPAEIGKIIAVDLPVVGDAKQALEMLLAEPV
                     VQNNTEKWIEKVTKDKERVRSYDKKERMVQPQAVIERIGELTKGDAVVVTDVGQHQMWT
                     AQYYPYQNERQLVTSGGLGTMGFGVPAAIGAKIANPDKEVILFVGDGGFQMTNQELAIL
                     NIYKVPIKVVMLNNHSLGMVRQWQESFYEGRTSESVFDTLPDFQLMAQAYGIKSYKFDN
                     PETIDQDLEVIKEDVPMFIEVDISRKEHVLPIVPAGKSNHEMLGVKFNA"
ORIGIN
        1 tcttcaacac ggtggtgagc agcatcgata atttcttgtt tgttatcgat aactgggata
       61 tcggcgatac ccactgtcaa accagcaaga gttgagtggt agtaaccaag gtctttcaaa
      121 cggtcaagaa aggctgatgt ttcggtcgta cgaagacgtt tgaaggtttc agcgatgatg
      181 ttaccaagat ttttcttctt gaatggtgca ttaatttcca aactatcaat aactgtttgg
      241 atatcttgac ctggttcaag gaagtactta tctggtgtac tatctgtcaa attctcattt
      301 gttgtttctt gaagatatgg aatttctgct gggatgatag agttaaagag aatcttacca
      361 acagttgtaa ccaaaatctt gtgaagttgg ttttctttcc aaggtttatc aggcatgctg
      421 tctactgcga taccgacacg gctatgcaag tgaacataac cattacgata agccataact
      481 gcctcatcaa tatccttgaa gaccatacct tcaccctcac ggccttcttc ttccatagtc
      541 aagtagtagt taccaagaac catatcctga gatggcgtta cgaccggttt accgtcttta
      601 gggttaagga tgtgttcagc cgcaagaagg agcaaacgtg cttcagcttg agcttcttca
      661 gacaatggaa cgtggatggc catttggtca ccgtcaaagt cggcattgta ggcctcacat
      721 accaatgggt gaagacgaag ggccttacca tcaatcaaga ctggttcaaa ggcttggata
      781 cccaaacggt ggagggtagg tgcgcggtta agaagtactg ggtgttcctt gataacatct
      841 tcaagaatat cccaaatacg ttcatcacca cgttcaacca tacgtttagc ggctttcacg
      901 ttacctgcgt attcacgcgc aacgatttca cgcatcacaa atggtttgaa aagttcgatg
      961 gccatcaaac gtggcacacc acattggtac attttaagtg ttggaccaac ggcgataacg
     1021 gaacgtccag agaagtcaac acgtttacca agcaagtttt gacggaaacg accttgttta
     1081 cctttaagca tgtggctcaa agatttaagt ggacgactac ctggtccagt gattggacga
     1141 ccacgacgtc cattatcgat aagggcatct accgcttctt gcaacatacg tttttcattt
     1201 tgcacgatga tacctggagc attcaattca agcaaacgag ccaaacggtt gttacggttg
     1261 ataacacgac gataaagatc gttcaagtca gatgccgcaa aacgtccacc atccaattga
     1321 accattgggc gaaggtctgg tggcaatact ggcaaaatgt taagaaccat ccattctggt
     1381 ttgttaccag acttatagaa ggcatcaaga acgtccaaac gacgaacagc tttaacacgt
     1441 ttttgaccag ttgctgtctt caactcttct ttgagttcag caatttcagc ttccaaatcc
     1501 acttgtttca agagatcttg gatagcttct gcacccattt tagcgacaaa tgaaccatgt
     1561 ccgtactctt gcaatttttc acgatattca cgttctgtca agagagattt tggttcaagt
     1621 ggtgttttct ttggatcgat aaccacgtaa gctgcgaagt agataacttc ttcaagcgca
     1681 cgaggactca tgtccaaagt caatcccata cgagaaggga ttcccttgaa gtaccagatg
     1741 tgtgatactg gtgctttcaa ctcgatgtga cccatacgtt cacgacgaac cttagcacgt
     1801 gttacttcaa caccacagcg gtcacaaacg atacctttat aacggatacg tttgtatttt
     1861 ccacacgcac attcccagtc tttagtagga ccaaagatta cttcgtcgaa gagaccttcg
     1921 cgttctggtt tgagcgtacg gtagttgatt gtttcaggtt tcttaacttc accataagac
     1981 catgaacgga ccttagttgg tgaagctagt gtgatttgca tacttttaaa tcgatttacg
     2041 tcaaccacta gtattacctt tcttttgttc tattgacaat agcagcgcta ttctcacctt
     2101 tatcagctac cttagcagag agagtggact ccctctctaa agcttattta ttctgtttta
     2161 tctgaagctt cttctttagc tttttctaat tcagcagctt ctttggcttg ttgtacacgt
     2221 gctttttcaa gatcatcgac gtgcatgaca tcgtcatctt caccttcatc aagatcacgt
     2281 aattcaactt cgtagtcatc ctcatcaagg acacgcatat caagaccaag tgattgcaat
     2341 tctttaacaa gtactcggaa tgattctggt acacctggtt ttggaattgg tttaccttta
     2401 gtgatagctt cataggcttt caaacgtccg ttaacatcat cagacttgta agtcaagatt
     2461 tcttgaagaa tgtttgaagc accgtaagct tcaagggccc aaacctccat ctcaccgaaa
     2521 cgttgtccac caaattgtgc tttaccacca agaggttgtt gagtaacaag tgagtaagga
     2581 ccaactgaac gggcgtgaag tttatcatca accatgtggt gaagtttgat catgtacatg
     2641 acaccaactg acacacggtt atcaaatggt tcacctgtac gtccatcgta aaggattgtc
     2701 ttagcatcac tatccatacc tgcttcacga acagtatccc aaaggtcttc tgagcttgct
     2761 ccatcaaaga ctggtgttgc gatgtggata cccaagttac gagcagccat accaaggtga
     2821 agttccataa cctgaccgat gttcatacgt gatggcaccc caagagggtt caacatgata
     2881 tcaactggtg taccgtctgg aaggtaaggc atgtcttcaa caggaacaat acgagaaaca
     2941 acccctttgt taccgtgacg accggccatt ttatctccga ccttgatctt acgtttttgt
     3001 gcgatataaa cacgaacaag catgttaaca cctgattgca attcatcacc gtttgcacgt
     3061 gtgaagattt taacatcacg aacgacacca tcaccaccgt gaggtacacg gagtgatgta
     3121 tcacgtactt cacgagattt atcaccaaag atagcgtgga gaagacgttc ttcagcagaa
     3181 aggtcttttt cacccttagg tgttacctta ccaacaagaa tgtcgccttc tttaacctca
     3241 gcaccgatac ggataatacc catttcgtca aggtctttga gggcttcttc accaacgttt
     3301 ggcaattcac gtgtgatttc ttcaggccca agctttgtat cacgtgtttc tgattcgaat
     3361 tcttccaagt gaacagatgt ataaacgtca tctttcacaa gacgctcact catgataacg
     3421 gcatcctcga agttgtaacc ttcccatgtc atgtatgcga caatagggtt ttgaccgagg
     3481 gccatttctc caccttccat agatggaccg tcagcgataa aatcaccttt ttcaacaata
     3541 tcgccaacct taaccaaagt acgttggtta taggcagtac ctgagtttga acgacggaat
     3601 ttttgaatag tataaacatc aagagaacca tcttcacgac gaacttcaac tttatcagca
     3661 tcagagtaga caactttacc gtcgtgttga gcaataactg cagctcctga atcgtgggca
     3721 gcttgatatt ccataccagt accaacataa ggtgctttag gatcaatcaa aggcacagcc
     3781 tgacgttgca tgttggcacc catgagggca cggttagagt catcgttttc caagaaagga
     3841 atacatgctg tcgcaacggc aactacctgt ttaggagaaa catccacgaa atctacaagg
     3901 tgtgatgggt actcttggtt attaccttga tgacgcccca taacgatctc ttctgcaaat
     3961 gttccatctt cgttcaattt agagttagcc tgagcaactg tgtactcatc ttcttcgtcg
     4021 gcagtcaacc aaactacttc gttggttact ttaccagttg cacggtcaac cttacgatat
     4081 ggtgtttgaa tgaaaccata cttgttaagg tgtccgtatg aagacaagtt attgatcaaa
     4141 ccgatgttag gtccttcagg tgtttcaatt ggacacatac gaccgtagtg cgtgtagtgc
     4201 acgtcacgaa cttcatatcc ggcacggtca cgtgtcaaac caccaggtcc caaggctgac
     4261 aaacgacgtt tgtgtgacaa ctctgacaat gggttgtgtt ggtccatgaa ctgtgacaac
     4321 tgtgaagaac caaagaattc tttaacagct gcagttacag ggcgaatatt gatgatttgt
     4381 tgtggtgtca agacttcgtt atcttgaact gacatacgct cacgtacgtt acgttccata
     4441 cgagccaaac caatacggaa ttggttagca agcaattcac caacagcacg gatacgacgg
     4501 ttaccaaggt ggtcgatatc gtctacttta ccgatacctt cagcaaggtt gaggaagtag
     4561 ctcatttcag ccaagatatc cgctgttgtc aaagcacgaa ctttgtcatc tgggttggca
     4621 ttaccaacaa ttgtaaccac acggtctgga tcatttggtg caacaacctt gaatttttga
     4681 agaacaacag gttctgtaac caccgcataa tcgtttggtg tgtatacaaa tttgttcaaa
     4741 tcaccatcca agtattctgc gattgaatca atcacatcac gtgtcatttc agtaccagct
     4801 tcaacaagga tttcacctgt ttcaggatct accaagtttt cagcaattgt ttgtcccaaa
     4861 agacgtgtct tgatgttaag ttttttgttg actttgtaac ggccaacagc agctaagtca
     4921 taacgacgtg gatcaaagaa acgagctaca agcaagctac gtgagctatc ggcagttttt
     4981 ggttcacctg gacgaagacg ttcataaatt tctttaagcg cttcatcagt acgtgaatct
     5041 gctgggtttt tgtggatatc tttttcaatg gtgttacgaa ccaactcgct atcaccaaag
     5101 atatcaacaa tttcgtcatc acctgagaat ccaagcgcac gcacaagcgt tgtgaatgga
     5161 atcttacgtg tacggtcgat acgagtgtag gcgatgtctt ttgaatctgt ttcgagctca
     5221 agccatgccc cacggttagg gataactgtt gatccataac ccactttgcc gtttttatca
     5281 accttatcgt taaagtaaac accaggtgag cgcaccaact gagaaacaat aatacgttca
     5341 ccaccattga tgatgaaagt acccatctca gtcataatag ggaaatctcc gaagaagact
     5401 tcctgagttt tgatttcacc agtttctttg ttaataagac ggaaagtcac aaagataggt
     5461 gctgagtatg atgcatcgtg gatacgagct tcttcaagtg tatacttagg ctctttcaat
     5521 tcgtaaccaa cgaattccaa ttccatagtg tctgtgaagt ttgagatagg aagtacatcc
     5581 tcaaaaacct ctttaagacc agtatccaag aattctttga atgaatccgt ttggatttca
     5641 atcaagtttg gtaaatcaag aacttctttg attcttgaaa aactacgacg ggtacgatgt
     5701 ttcccgtatt gaacgtcatg tcctgccaag tcttctactc cttttctaca ttcgagacct
     5761 gctttgcaag tcgtgcactt taaatatttg tcttctgcct ttttcagttg cttgtcccat
     5821 tgacaagtga ttaaacacta agatccactt aactgattaa tgataagcga taacttaatc
     5881 tgtgaatttt tagaaccttt aaacatgcgt tacaacactt ggaaatccta aaaataagca
     5941 caaaaatagc agctaaatct gaccgaaaaa acgttgattt aactgctgta tctcttgatt
     6001 ggacaatatt tcaaccaagt aagacgacaa atagttgtct atattatacc taatttttta
     6061 cttttttgca agttttcttg gcaattccta atgccctcca agaatgctag accaggcttt
     6121 ttgatagtca ctgtcggttc caccaatagc aaacttgtaa gtcgtatctc caggtccatt
     6181 tttagcccag taagtatcaa ccatttcacc acttacagaa acattacgac cattgacaga
     6241 cactgttgct ggtttaagac ctgttgattt aagcacactt gccttaatgg cacttgaatc
     6301 gatattaaac ttatctcccg ttttaaaaat acctggatta gcattataga tagcggaagt
     6361 caaacgagcc atatattggg aattatatat gtaacccgtt ttagaattgg ttggtgtatt
     6421 attatcatat ccggcccaac caccaagagt aataccaggc gttgacacaa tcagccaagc
     6481 atccgcaaag ttatctgtcg ttcctgtttt acccatccag tccgctgagg ctgctgcacc
     6541 attgacattt ttcaattcag aatgaaattg agttgttgct cctttaacta ccacttcttt
     6601 gagtaagtta tccatgatac tagccgtagc tcttgaaaaa acttgaactc cttcagattt
     6661 atgctgatag ataacttcgc cagtccggtc agtaatacta tcaatcatat ggcccttctc
     6721 atagacgcca ccattggaaa gcatttgata ggcatttact tgctgggcaa ccgtagtttc
     6781 aattcccccg ccaagaggta aactttcgat attgtagtta gcaatcttat aacccatctt
     6841 ggtcatgtaa ccctcaacat caacatcatg acgttgaagc atttgataag tccaaaaggc
     6901 tggaatgttc catgaggtat tgagtgcctc ttgtaggttc atcatagctg tacccttatc
     6961 accatcatgg agaataggcg ttccacccgt aaaattagtt gggtagttag aaaggatact
     7021 tgagctaccc atcaaacctt gatcaatagc aattccataa gcgataatag gcttaataga
     7081 ggaacctggg gagcgtgccg tatcaaaggc atggttattt tggttatttt cgtaactacg
     7141 accaccaaca aatcctagaa ttgctccggt cgcattatcc atgagcacat ttccgacttc
     7201 aactccacta ttacctcctt ggtcaaggag gccaccatat tgactcgcag catcttgcat
     7261 cgcattataa actgcattgt caatagttgt cttaacgctg tagccaccgg tttggagctc
     7321 ttgaagagcc ctctcacgat agctttcctt tgtcttatca tttttcaact cttgactcga
     7381 taccttgtca tgtttaacga ggtaatcata catgacaccc tgagcctcag acatgacaga
     7441 atagtacaaa tagtcatgac ttacggcatc agacttctca ccagccttga aatctttagt
     7501 gatatcataa ttcttatagc tttcgtactg cgacttatct agatagccac cgcgataaag
     7561 attgtagagt acatcttgtt gacgtgccaa gccataagaa agatcctctg cgttttttaa
     7621 ttgtccatca gctgtataag gtgagtagac aattgggctc tgtggtaaac ctgccagata
     7681 ggcagcctga ggaactgtca aatccgctgc agatacgcca aagatacctt gagcagcctc
     7741 ctcaatacca gcaatatttt tccccttgtt attacgtcca aaaggagaaa cattcagata
     7801 atcggttaaa atttcatttt tagaaacacg acgctccaat tgtaaggcat agataatctc
     7861 tgccgcctta cgtttaaagg ttggtgcatc tcctgttacc tgttgcttaa ttaactgctg
     7921 cgttagcgtc gaaccaccac ttgaagagcc aactcccaaa actgatgaca ccaaagccct
     7981 aaatactgcc tttggcacaa cacccttatg cttcttaaaa ttttcatcct cagtcgcaat
     8041 gatggcattt ttgacattgt tagaaatcgc atcactctca ataggtgttc tcagcaagtc
     8101 agtatcaata tccgcaatct tcttagaatc ggaatagctc atcgaagata ccaaactaac
     8161 ctcactaatc tgattcaaca aggttttgtc cttaatcgac ggaacagtct caatttgact
     8221 ccccaaataa cccaaaccaa ttcctgcacc gaacaaggta aggacgataa taaccacata
     8281 aaagaaatca gacaaaagct ttaaggtttt taagaaaaca tcgcccatgt ctaagagtgt
     8341 catccggtcc tcaggcgact ttctcccttg cttacgattc cacttagaat cagtcgtaga
     8401 tttcctttca ttaaaagatt tatcccctct tttagaccta aaaccagcaa accttgtgcg
     8461 aatagcctgc cctagtcgtc taaaataatt tattattttt tcaaaattca tagaaatacc
     8521 tcaaagccta ttataacaaa ctttgacaaa gcttgcatag gactactttc ttttggtata
     8581 atggtgcaga atatacttta ctggagaata tcatgacaat ttttgaagaa ctaaaagcac
     8641 gtggcttgat ttttcaaacc acagatgaag aagcccttgt aaaagccttt gaagagggac
     8701 cagtctcata ctacactggt tatgacccaa cagcagacag tctccacctt ggacaccttg
     8761 tagctatcct tacaagtcgc cgacttcaat tggctggaca caaaccttac gccctcgttg
     8821 gtggtgcaac aggtttgatt ggtgacccat catttaaaga tgctgaacgt agcctccaaa
     8881 ccaaagaaac cgttgaaggt tgggttgaaa aaatccaagg tcagctctct cgtttccttg
     8941 attttgaaaa tggcgacaac aaagccgtta tggtcaacaa ctacgattgg tttggttcag
     9001 tcagcttcat cgatttcttg cgtgacgtgg gtaaatactt cacagttaac tacatgatga
     9061 gtaaggaatc tgttaagaaa cgtattgaaa caggtatctc ttacactgag tttgcctacc
     9121 aaatcatgca aggttacgat ttctatgaac tcaacgataa gtacggcgta accctccaaa
     9181 ttggtggttc tgaccaatgg ggtaatatga cagcaggtac tgagctcttg cgtcgtaaag
     9241 cagataaatc tggacacgtc attacagttc cacttatcac agattcaact ggtaaaaagt
     9301 tcggtaaatc tgaaggtaac gctgtctggc ttgatgctac taaaacaaca ccttacgaaa
     9361 tgtaccaatt ctggctcaat gttatggatg acgatgctgt tcgcttcttg aagattttca
     9421 ctttcttgtc acttgaagaa atcgaagaaa tcggtaaaga atttgaccaa gctcgtcacc
     9481 aacgtttagc acaaaaggtt ttggctcgtg aagttgttac cttggttcac ggtaaagatg
     9541 cctacgaaca agctgttcac atcactgaac aactcttcgc tggtaatctt aaagctctct
     9601 cagcacgcga ccttaaagtt gcccttaacg gtgtcccaac ttatgagatc tcaggagatg
     9661 aaaatctgaa catcgttgaa cttctcgtca acgctaagat ttcaccttct aaacgccaag
     9721 cacgtgaaga tgtccaaaac ggtgctatct acatcaatgg tgaacgtgta caagacttgg
     9781 attacaccct ctcagatgca gataaaattg ataatgaaat tactgttatc cgtcgcggta
     9841 agaagaaaaa ctttgtcttg acttactaat tttatggcta ttctcactcc ttaatggagt
     9901 gagttttttt ttaccaaaaa agagcagtag gattgattac caactactct cttcagaaca
     9961 caaaaaaacc agtactaaac tggtttttga gactatcaca ttagttatag attttgaatg
    10021 cgtcatcgtc gttttgacca acgaatggca ttgctttacg caattcagca ccaatctttt
    10081 caatttcaag ctcttcagct tctttacggt aagctttcaa acgtgggaag ccagcatcat
    10141 ggtcttcaac gaattcacgt gcaaatttac ctgattggat atcagcaagg gcagctttca
    10201 tgttttcttt gacttctgga ccgatgacac gtggaccagt tacaaagtca ccaaattctg
    10261 cagtatttga acatgattga cgcattttct tgaatccacc ttcgtagatc aagtcaacaa
    10321 tcaatttcat ttcgtgaagc acttcaaagt aagctaattg tggtgcatag cctgcttcag
    10381 tcaagacttc aaaaccagct tcaataaggt gtgtcaaccc acccataaga accgcttgtt
    10441 caccaaacaa atcttcttca gtttcttctt taaatgttgt tacaagtaat ccaacacgtg
    10501 cagaaccaat acctttagcc cagtccatag cgatatcttt agcattacct gtagcatctt
    10561 ggtatactgc gtaaagtgca ggaacaccaa agccttctgt atatgtacgg cgtaccaagt
    10621 gacctggtcc tttaggagca accataaaga catcaacatc tttaggaacc ttgatgaatt
    10681 cgaagtggat gttaaatccg tgtgcaaaac caagagcttt gcctgcactc aagtttggct
    10741 caatttcatc tttatagata tctttttgaa tttcatctgg tgccaaaacc ataatgatat
    10801 cagccaattt agttgcttct gctactgtgt aagtatcaaa accatcttct ttagctttat
    10861 caaatgattt acctggacga acaccgatga tcacatcgtg acctgaatca cgcaagtttt
    10921 gtgcatgcgc atgaccttgt gaaccgtaac cgataacggc gattttttta ccgtcaagtg
    10981 ctgctacttt tacgtctttt tcatattcca tttgaactgc catagtaata tgtctctttt
    11041 ctaaaaaata ttttattgcc tttttaaggc tgggttaaca aatttaggtt ggatttttta
    11101 atcacgggta aatccagtag cacccgtacg agcgatattc ttgattccgt aaggacgaat
    11161 aactcgtaga agcgcctcgc tcttttcagc atcaccagtc atctggatag tgatagagct
    11221 tggtgccaca tcaaccaccg aagcacggaa aggttgaata atcgccaaga tttcagcacg
    11281 cttagaggtt ggtgctgata ccttaactag gataacttca cgttccaagt gtggctgatc
    11341 cgtgatatca cggatacgga tcacatcaat ctgacgatta agctgtttga tgatttgttc
    11401 cacttcattt tgagaattca catcaataat aatcgtaata cgtgaaacgt taggatcctc
    11461 agaagcccct acagagatac tttcaatatt aacttgacgt cgtgaaagaa cacctgtgaa
    11521 gcggttaagg acacccgaac ggttctgaag tttagctgtt aacattctac gcattgaact
    11581 tcacccccaa catttcatga ttactcttac cagccggaac gattggcaag acatgctctt
    11641 tacgagagat atccacctcg atgaacattg gtacgtcttc cttgataact tccaaatcct
    11701 gatcaattgt ctctggatta tcaaacttgt aggacttaat gccgtaagct tgagccatca
    11761 attggaaatc tgggagggta tcaaagacag actctgatgt acgcccttcg tagaaggact
    11821 cttgccattg acgtaccata ccaagtgagt ggttgttcaa cataacaacc ttgattggca
    11881 ccttgtaaat atttaagata gccaattctt ggttcgtcat ttggaaacca ccatcaccaa
    11941 caaagaggat aacttcttta tcaggattag caattttagc accaattgct gctgggacac
    12001 cgaatcccat tgttccaaga ccacctgagg tcaccagttg acgctcattt tggtatggat
    12061 aatactgagc tgtccacatt tgatgttgtc caacgtcagt aacaacaacg gcatcaccct
    12121 tagtcaattc accgatacgc tcgataactg cctgaggctg taccatacgt tctttcttat
    12181 cgtaagaacg tacacgttct ttgtcttttg tgactttttc aatccatttt tcagtgttat
    12241 tctgaaccac tggttctgct aagagcattt caagagcttg cttagcatca ccaacaactg
    12301 gaaggtccac tgcaataatt ttaccaatct cagctggatc tacatcaata tggacaacct
    12361 tagcattctt agcaaatgtt ttaggattac ctgtcaaacg gtcatcaaaa cgacaaccaa
    12421 tagcaatcat aaagtcagca tccgtcatag caatgttagc cgcatatgaa ccgtgcatac
    12481 cacccatacc caagaaaagg ggatgactag tagcaattgt cccttgtcct agaagacttg
    12541 tgacaactgg gatttggtag cgttctgcaa aagcaactag ctccttagca gattcagaat
    12601 aagacacccc acctccagct acaataaccg gtttcttagc tttccccaac tgcttcaaga
    12661 ttttcttgat ttgcatttcg tttggtctta gcgtcggttg gtaacttgga agattaattt
    12721 caggatcgtt gatgaaggct gtttccttag ctacgacatc tttagggagg tcgataacaa
    12781 ctggaccagg acgaccagtt gttgcaatat gaaccgcttc cctaataata cgaggaatat
    12841 cagctgtatc gcgaatctga taattgtatt ttgtaatcgg catggtaatt ccgacaatgt
    12901 cagcctcttg gaaggcatcc ttaccaatac ctgatgttgc tacctgacca gtaaagacta
    12961 ggagaggtac gctatcactc atagcatctg caatccctgt aatagcatta gtggcaccag
    13021 gaccactcgt tacaagagca acaccgagtt taccagttga tttggcataa ccttcagctt
    13081 cgtgcagact tccttgctca tgacgagata agatatgatt aatcttgtca tttttgtaaa
    13141 tagcatcata caaaggaaga accgctccgc caggatatcc aaagatagtt gaaatcccaa
    13201 gttcaagaag tgtatcaaga atcaaatcag caccagagcg tgcttcttca agttcaattt
    13261 tcttcacatg gacctccttt agtagttgtt tttttcgaat tgtctaaaaa ttcaaaacct
    13321 tgtatactat gataacattt ttaaccaaat ttgcaagggt ttcagagaaa aatatcacaa
    13381 actcttcgga aagaatgttc ttccctaatt gtcaagtcaa gtgcaacaaa gatgttcctc
    13441 tgattaagtg agtatctttc aagctgtttg agttagctc
//
