LOCUS       c00054_JABERP0..       16660 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JABERP010000062.1 Lactobacillus crispatus strain CRI10
            LcB146_contig_62, whole genome shotgun sequence.
ACCESSION   JABERP010000062
VERSION     JABERP010000062
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 06:26:24
            Original ID  :: JABERP010000062.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 51631
            Orig. end    :: 68291
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16660
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[56631:63291]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..11660
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..16660
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16660
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(704..1918)
                     /locus_tag="ctg54_62"
                     /transl_table=11
                     /translation="MNKIWLVAKETYRREVKTWSYLLMILAPFLLVFFSFVIGMVSAGG
                     SDDNYVGVVTSNSALKQAIKKSEDFDNYSTEAKAKKAYKDEDIDGYVLIEQKNNQLAAT
                     YYSDEKMDSDLKSELLTSLNTAQQQLNLSKAKLTTKQTQSLATRAQFKQQVKHVDKKSF
                     DNDPVKQISFWVLLIILYMLVITYTQVTAQDIATEKGTKIMEVIFSSMPGGDYFTGKIL
                     GIFGEIITQVLIYVVGFVAVYCAAPYIDGFSDLFRQYKPMIDQAIGNLASWGLVFTIIG
                     LVLFIIFAAFCGALVAKSENANKAVGPLSTLMLIGFLFTVNMQSGGDTIFAKVLSYIPF
                     LSSFVMPARVIMGNATNLEAAISALIALAATVASFIWIRKIYPNLILQTDDVGPWQNFK
                     RSLRG"
     CDS             complement(1911..2807)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 168.6; E-value:
                     3e-51)"
                     /gene_kind="transport"
                     /locus_tag="ctg54_63"
                     /transl_table=11
                     /translation="MLKIEHLNKSFGSTQVLFDVSFSVSDGRILGLVGKNGSGKSTIFH
                     SILKFVDYDGQISIDGHSFNAKDYDNIGYLPEERSLMPKLTISDQVVFLASLKGMPAKK
                     VKEELPDWLSRLAVKGIPMDKIKSLSKGNQQKVQMIATLIHQPKLIILDEPFSGLDPVN
                     VDLMKQLILEEKRKGATIIFSDHDMRNVEELCDDVVMINDGHIVLNGPVNEIKNSFGLT
                     RIFVRTDKSATELSALPGVKDIILQNNGMKLLILADEKYGKDIFNQLSAGQYIQTFDQE
                     PPTLDEIFKMKAGARHE"
     CDS             complement(2825..3247)
                     /locus_tag="ctg54_64"
                     /transl_table=11
                     /translation="MNNEKFARENKRIIEGMGIGALVGPILALVMMYVKTAGSPQPFQI
                     IMSIGAGLAFGLMFGGIMSASLVLNKTVASKIPWQKKVLKLAPQVIGTGVVVASAGVVI
                     TLVTNWGSVDIVKTIFSTDTLWQFFDGVLLGLITIR"
     CDS             complement(3274..3465)
                     /locus_tag="ctg54_65"
                     /transl_table=11
                     /translation="MLYLIYIVLGLLIILAVNYAVTAFLAVHDLLENREKDQLSFGDAF
                     KKYFAKNNIPTKFSDLFN"
     CDS             complement(3598..3807)
                     /locus_tag="ctg54_66"
                     /transl_table=11
                     /translation="MIEVTLDFMLLKRKMSSKELAEKVGITPANLSILKTGKAHGVRFD
                     TLSKICEVLDCQPGDLLVYKKDEE"
     CDS             complement(3822..4361)
                     /locus_tag="ctg54_67"
                     /transl_table=11
                     /translation="MKKLILNLLTIFAWIYQIFCVIGIIMWIVMGGVVLFGIHNPDFRA
                     GFESGRGIKGVSVDNYIGAIVVVLLSLIMMSVAAFLICRYARLIVKNIKQEVYFADSNL
                     NLLKKLLISVAGYTLISIIDYIIFITHRTWFAKSSNNVLYPSGVTTGLLFLAVLYVVYL
                     VFKYGMKVQEDADSII"
     CDS             complement(4366..4548)
                     /locus_tag="ctg54_68"
                     /transl_table=11
                     /translation="MLPEKKRQIGSIIGMLIMMAILVFANLGGTWSVLRITLLVIGVTG
                     VIGSAIYRIIHILRG"
     CDS             complement(4716..4931)
                     /locus_tag="ctg54_69"
                     /transl_table=11
                     /translation="MKNKILTERQVRNRSIIAGILALLIGLVWDYFQYKTLSFGTVFWN
                     IVESVAFVIFMNIFMNSYYKKKSKKQ"
     CDS             complement(5001..5195)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg54_70"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 2.4e-08,
                     bitscore: 27.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMKEMNYKELEKVSGGTNWLGVGGSCLSGFIDALPSGSGMIKGCV
                     EGAVKDFAKQNRHKKHKHR"
     CDS             complement(5213..5464)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg54_71"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 6.3e-15,
                     bitscore: 48.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKFETLTYEELSAVFGGNGGKARRRRKITNCAKAIGMGALKDGL
                     KYGIAGTAFGTPIGTVGGAIFGANVGIISGSVSCVSHL"
     CDS             complement(6057..6254)
                     /locus_tag="ctg54_72"
                     /transl_table=11
                     /translation="MKRIIISKDEVLLSGILGGSGSVDDIGLTDTEHMLPLYSKKGGNH
                     KRDVYLENPKFFQSSFHRGR"
     CDS             complement(6255..7559)
                     /locus_tag="ctg54_73"
                     /transl_table=11
                     /translation="MNKKKILMLMLSPAVLLMMNSTIVHADEGNTSQENKSEVVSKTEN
                     DDKNVSESEQKTSSKNEAAQTQNKQEEEPAASEDQNNQSQNTNNQDPNNANEEDSEDDE
                     DEVSVEDYENNVKDFHRVKMQEVKDLLAEKNNQEHLMYIGRPTCYYCRQFSPDLKDFNE
                     IVKGKLLYFNIDAEEGAHEYAFKEIGIPGTPTTMRFINGKIISAWVGGEKTGQELYNFL
                     YSDAANKLVEQAVIKDQPKDDNTTESESNEIPEVTVAEDDQTQSSNDVAITDFVENSVF
                     ENAANVASSTADLTKVTTGNQEYAAPRAETKKKTVKKPVKPKIVATKVKKTAKSHKKNI
                     ILAAVSEKHGSVKENKQFDSVKVQSKPYSAVKNNQNRITKLKRLENDTIKNGSTQSLPS
                     TGEKDNIWGQLIGMISILISLVLGISLGKKTKEEK"
     CDS             complement(7714..8310)
                     /locus_tag="ctg54_74"
                     /transl_table=11
                     /translation="MNNKDYESTEYYSYKFKNFSTMIIIPMAILVLILIVGSFFATRQS
                     TVTSTGIVEPQNTLNIANRNYHEGQIVRRNREKWLVHLDDKQENTVHLFPMIKAKRTVN
                     VVTYFPGNKIGAIKKGQTLYFQVANASGTMDRLVGKVKEIGVYPINLRGNNVYEVICKA
                     KSKKNLKYGMEGNATIITGKSTYFEYFKDKILNQN"
     CDS             complement(8321..9004)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 183.3; E-value:
                     9.8e-56)"
                     /gene_kind="transport"
                     /locus_tag="ctg54_75"
                     /transl_table=11
                     /translation="VLHFNFKSGKDINLKIEPNDKLAIVGMSGSGKSTMVKLLVDFFSP
                     SKGKLTFNGFNSTKVDKHVLRSYVNYVPQTPYIFSGTIKENLLLGSRPDITEKDILKAC
                     QIAEIESEIEQLPLQFETKMDENAKILSGGQKQRLTIARALLSPAKILIFDEATSGLDT
                     ITEKKVVDNLMKLKDKTIIFIAHRLAIAQRTNNIVVVDHGQIVEQGSHEKLMQKHGFYY
                     NLVEN"
     CDS             9075..10109
                     /locus_tag="ctg54_76"
                     /transl_table=11
                     /translation="MTNSNSSISKHYHQLTSVQRGQIQAMLDSGITSRTVIAQEVGCHK
                     STISREIKRGSVLQRDSSYLLYEHYYADTAQIYYEKRRKNCYQRNPLKHYAVFLRMLSR
                     RFKAKFDATSIDEFVGEFKRTMPGYPCPSTPTVYRYIDQGLLDISNIDLPMKLKRRRNK
                     RHHSHGGHALHKKHLGNSIEQRPKEIEDRKTPLHWEGDLVKGVRRKNQPALMTLTERTT
                     RFEVVIKIPDYRASTCQRLLQNEIDRHPAWFKSITFDNGSEFADMTKIKGCQIYFAHPY
                     SPWERGTNENCNGLLRQFFPKGKSMKDKSAAYVQQATDAINHKYRRILQYHTAEELFKQ
                     YISS"
     CDS             complement(10137..11660)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 131.5; E-value:
                     6.3e-40)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg54_77"
                     /sec_met_domain="TIGR01193 (E-value: 3.1e-222, bitscore:
                     733.1, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.2e-44, bitscore:
                     144.6, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLLQYKSIYVPQVDESDCGVACLAMILKKYHSRVFLAHLRHSART
                     NLEGTTALGLVKTAQAFNLKTEAVKADMSLFDPDADIQYPFIVHVLKQGELLHYYVVIK
                     ATKNYLVIADPDPSVGLTKMSKEKFSQEWTGIALFMVPNDDFEPLKEKKQNLWSLFPYM
                     FKQKKLVTNIILAALLMTIISICSSYFLQGLIDTYIPSGTYQTLSILAIGLLIAYVFNS
                     IFSYGQNFLLDVLGQRLSIDLNLQYIRHIFELPMEFFVTRRTGEITSRFSDASRIIDAL
                     ASTVISLFLDLSIVIVMGIVLAIQNSTLFVITLLSLPIYAVVILSFSKKFEKMNNDQME
                     SNAVLSSSVIEDIQGIETIKALNSEQTRYRKIDSQFVDYLKKSFRYSKTESLQSALKTF
                     IQLSLNVIILWVGAKVVMNGQMSIGQLMTFNALLSYFVDPLQSIINLQPTLQSANVAQN
                     RLNEVYMVKSEFQKDAQIRDAKQLAGEIEYHHVDYHYGYGVDVLKDINS"
     CDS             complement(11784..12584)
                     /locus_tag="ctg54_78"
                     /transl_table=11
                     /translation="MSKFPIIVCDDDKDLANQIAKNINASIQDLIDDNEGYAELNESVT
                     FVANDFAQAVGYIVTNDIKNGIYFLDIELSRESKAKNGVDLAEFIKKNDENAQIIFVTA
                     YDKYAPLTYRRRIGAIDYISKSMSSDKIIQRIEETLRNAFDNLSNRIKFSQRDFTYKIG
                     RRVCKVAEGDILFIEHSTTQHKVHMVTENGEVEYKANITQIDKENPFLAKVSQSSLVNP
                     KNISAIDTKERIIIFDNGQMVTYSRSYKAVVKKLVDKFENIKVE"
     CDS             complement(12577..13608)
                     /locus_tag="ctg54_79"
                     /transl_table=11
                     /translation="MITQVMSFTLIGQLSLRFLLILMMIVAIKLGNGKIYNYLANQNNK
                     IFVGILAYTYVSTVSISIIYIQSKSFTPLTLFFSLYILIQTIFAIFIYHEMTMVQEKLL
                     NKKDQEKLKQQQHQLEEYASYLEKSEDDLRAFRHDYKNILNSLKVSAQEGNVQEVIQKL
                     DKYTETNLNSKALLKYKDLNHIYVKSIKSIIIPKITELYNLDIPYNFECRNNIRNLPDH
                     VDELDLVRIIGITFDNAIEESKALIAEKHDIRSAEVQIMVYSDDPDEFEFEIRNKIQNK
                     NISTSQIQQRGFTTKKDHKGLGLANIKEIESKYPDMSISYTIQDGWFDFYMTIDTEDGE
                     EDE"
     CDS             complement(13782..15008)
                     /gene_functions="other (smcogs) SMCOG1130:transposase
                     (Score: 411.7; E-value: 3.6e-125)"
                     /gene_kind="other"
                     /locus_tag="ctg54_80"
                     /transl_table=11
                     /translation="MIGLNKKNTYRKKNSFMNDFTKDFAQALFNPDKINDLLRKELQQA
                     VNNLLEAELTAFLGYDPYARNGWNTGNSRNGAYFRKVDTQFGPIEVQVPRDRNGQFHQH
                     TLPDYKQHSDILESMIIKLYSKGVTTREIADLIEKMYGSHYSPAQVSNISKQMLPKVEA
                     YHKRKLSDKFFCVYLDATYLPLRRETFEREAVYIAIGIKPNGHKEVIDYCIAPSENIEV
                     WTEMLQNMKSRGLKQVELFLSDGVVGMKAALTRTYPKAHFQRCLVHVMRNICAKVRVDD
                     REKIMNEFKQVHQQTNKEEATAVLHDFYTKWGKVYSHVIRSLKDIEPDLLVFYNYPKQI
                     RASIYSTNMIESFNNVIKRKAKPKAEFPTEQSLDAFIGIQAMSYNDRYFNRIHKGFGQV
                     QDTLESYFD"
     CDS             complement(15274..15405)
                     /locus_tag="ctg54_81"
                     /transl_table=11
                     /translation="MKKQNVKKTVLKEEELTKVVGGSTAHVGFNFLSKKLWNNIWKR"
ORIGIN
        1 taaactgcat aaagcagtct ctacaccatt agtaataatc ttgacgttag caacctctgc
       61 taaaaatggt accatctcat aagttgttgt tcctgcatca atgaagacat tgtcacctgg
      121 acgaacaaaa ttctgcacgg catatctagc aatagtgatt tttgcgtcat gattcaaact
      181 gaagcgaacg ttttgtgata catcacgaga aaaatgttta actgattggg caccgccatg
      241 aacacgctta aggatcccat ttttttccat ctgaattaga tctcgacgga tagttgattc
      301 agatgttgcg gttaagtcac ataattcact tacgcgacat aactcgtgtt gattaacata
      361 gtcttcgatt aagctttggc gctcctgagt cagcatcatt tctcacctcg ataaatattg
      421 tattcgcttt ctcctccaaa atcaatcatt tttcttcaaa aaatgtcatt tttatttatt
      481 atcgttcaat aacattcatt tatatgcaaa aaagatgccg ttttttgatt gaaacgacat
      541 cttttcttcg tcatttggaa ttattcttag tcgttttacc ctatttgact aagaatccgt
      601 aaagatgact aagaaagaga accaaagatc tattaacctt gcaaaagcaa aacacgctga
      661 atcattattg attcagcgcg ttttactatt aaatatattt tgtctagcct ctcaagctac
      721 gcttaaagtt ttgccatggg ccgacatcat ctgtttgcaa aatcaagttt ggatagattt
      781 ttctaatcca gataaatgac gctactgtag cggctaaagc aattaaagca gagatagctg
      841 cctctaaatt agttgcgtta cccataatta ctctagctgg cattacaaat gatgatagaa
      901 acgggatgta cgataatact ttagcaaaaa tcgtatcccc acctgattgc atattgactg
      961 tgaacaagaa cccgatcaac atcaatgtag atagtggtcc caccgctttg ttggcattct
     1021 cgcttttagc aaccaaagcg ccacagaaag ctgcaaagat aataaacaat accaagccga
     1081 ttatcgtaaa caccaatccc caagaagcca gattgccaat tgcttgatca atcatcggct
     1141 tatactgtct aaataaatcg ctaaagccat cgatgtatgg ggccgcgcaa taaactgcca
     1201 caaaaccaac aacataaatt aacacttggg tgataatttc accaaaaata cctaaaatct
     1261 tcccagtgaa ataatcgcca cctggcatac tcgaaaagat tacttccatt atcttggtac
     1321 ccttctccgt agcgatatct tgtgctgtta cttgcgtata agtgatcaca agcatgtaca
     1381 agataatcag caaaacccag aaggaaattt gcttaacagg atcattatca aagctcttct
     1441 tatcaacatg cttaacttgt tgcttaaatt gcgctcgcgt agctaaagac tgagtctgtt
     1501 ttgtcgttag cttggcctta cttaaattca attgttgctg ggcggtgttt aggctagtta
     1561 gcagctctga ttttagatca ctgtccattt tttcatcact atagtaagtt gcagctaatt
     1621 gattattctt ttgttcaatt aaaacatagc catcgatatc ttcatcttta tacgcctttt
     1681 tagccttagc ttcagtgcta tagttgtcaa agtcttctga ctttttaatt gcttgcttta
     1741 aggcagaatt agaagtaact accccgacat agttgtcatc actgccgcca gctgatacca
     1801 ttccgataac aaatgaaaag aagacgagca gaaacggtgc taaaatcatc agcaaatatg
     1861 accaagtttt cacttctcta cggtaggttt cttttgcgac aagccagatc ttattcatga
     1921 cgcgcacctg ctttcatttt gaaaatctcg tctaaagttg gaggttcctg gtcaaaagtc
     1981 tggatatatt gaccggccga aagttggtta aaaatatcct taccatattt ttcgtctgca
     2041 agaataagca gcttcattcc attgttttgc aaaattatat cttttacacc tggtaaggct
     2101 gataattcag tagcactttt gtctgtcctg acaaaaattc gagttaggcc aaagctgttc
     2161 ttaatttcat ttactgggcc attcaagacg atatgcccat cattgatcat tacgacgtca
     2221 tcgcacaatt cttccacgtt acgcatatca tgatcagaaa aaatgatcgt agcgcctttt
     2281 cttttttctt ccaaaatcag ctgcttcatt agatcaacat taacaggatc tagtccactg
     2341 aatggttcat ctaaaataat caatttaggt tgatgaatta aagttgcaat catctgtact
     2401 ttttgttggt tacctttaga caaagactta atcttatcca tggggatccc tttaacagcc
     2461 aaacgtgata accaatcagg caattcttct tttacctttt tagccggcat ccctttaagg
     2521 ctagccaaaa acactacctg atctgaaata gttaacttag gcatcaaact tcgctcttca
     2581 ggcagatagc caatattgtc ataatcttta gcgttgaaag aatgtccatc aatactaatc
     2641 tggccgtcat aatcaacgaa tttcaaaata ctatgaaaga tcgtcgactt acccgaccca
     2701 tttttaccaa ccagtccaag aatacgccca tctgacacac tgaagctaac atcaaacaaa
     2761 acctgtgttg acccgaagct tttatttagg tgttctattt ttaacataat ttttcctcaa
     2821 ctttttatct aatggttatt agacctagaa gtacaccgtc aaagaactgc cataaagtat
     2881 cggttgaaaa aattgttttt acaatatcaa ctgaccccca attggttact aaagtaatca
     2941 ctacaccagc tgaagcaacc actactcctg taccaataac ttgaggggca agtttcaaca
     3001 ctttcttctg ccatggaatc tttgatgcga ccgttttatt aaggactaag cttgcggaca
     3061 tgatgccacc aaacattaga ccgaaagcca atccggctcc aatcgacata ataatttgaa
     3121 aaggttgagg cgaaccagca gtcttaacat acatcatcac aagagctaat attggtccaa
     3181 caagtgctcc aattcccatg ccttcaataa ttcgtttgtt ttcacgagca aatttttcat
     3241 tattcattgt tcttacctca aggaaatttt cagctaatta aacaaatccg aaaacttagt
     3301 cggaatgttg ttcttggcga agtatttctt gaatgcatcc ccaaaactca attgatcttt
     3361 ttctctattt tcaagcaaat catgaacagc taagaatgct gtaacggcgt aattaacggc
     3421 taaaatgatt aacaaaccga gcacaatata aattaagtac agcattgttc tttcctccaa
     3481 ttcagcgatt atctcccagg aaataatctt ttatcctttt aaattaatca tatccccatc
     3541 atttatgtaa aaggtaaaac cgtccaattc tgtcattttt cggactgatt ttgcatttta
     3601 ttcttcatct tttttataaa ctaataaatc ccctggttga caatccaaga cttcacagat
     3661 cttgctcaac gtgtcgaagc gaacgccatg cgcctttcct gtcttcagaa tcgacaggtt
     3721 agccggcgtt ataccaactt tctctgccaa ctcctttgaa gacatctttc gcttcaagag
     3781 cataaaatct agtgtcactt caatcatcta tatcaacctt tctaaataat cgagtctgca
     3841 tcctcctgaa ccttcattcc gtacttgaat accaagtaga ctacgtatag tactgctagg
     3901 aaaagcaaac cagttgtcac accacttggg tatagtacat tattcgagga tttagcgaac
     3961 caagtgcggt gagttatgaa aataatgtaa tctattattg aaataagggt atatccagca
     4021 actgaaatta ataatttctt gagtaaattc aaattactat cagcaaagta aacttcttgc
     4081 ttgatattct taacaattaa tctggcatat cgacagatta aaaaggctgc aacgctcatc
     4141 atgatcagtg atagcaacac aaccactatt gcaccgatat agttatcaac tgatacgcct
     4201 tttatacccc taccactttc aaagccagca cgaaaatccg gattatgtat accaaataac
     4261 acaacacctc ccataacgat ccacataatt attcctatca cacaaaatat ttggtaaatc
     4321 caagcaaaaa tcgtaagcaa attcaaaatt aattttttca tttttctatc ctctcaaaat
     4381 atggatgatt ctgtatatag cactgccaat tacacccgtt actccaatta ctaataatgt
     4441 aattctaaga acactccatg ttccgcctaa gttagcaaac actaagattg ccatcattat
     4501 cagcattcca ataattgaac ctatctgtct tttcttttct ggaagcatat ctatccctct
     4561 cttccataaa actatctatc tctttctcgt cttttataat tattgtatta cgataattta
     4621 taattgcaat acagaaataa aatatttttt tgagataata aaaaaatacc aaattagtcg
     4681 ttaaactaac ttggtattat gttttatctt ccaagctact gctttttact tttcttctta
     4741 tagtaagagt tcatgaaaat attcataaag ataacaaagg ctacactttc aactatattc
     4801 caaaatactg ttccaaagct taatgttttg tactgaaaat agtcccatac caatcctatt
     4861 aacagggcca aaataccagc gatgatactt ctgtttctaa cttggcgctc ggttaaaatt
     4921 ttatttttca taatttttac cccattatta tcatatcgaa aaataggaaa tctattaacc
     4981 gaattttcta ttttttaata ttatctatgt ttatgttttt tatgtctatt ttgtttggcg
     5041 aaatctttaa cagcgccttc tacacatcct tttatcatac cacttccgct agggagcgca
     5101 tcaatgaaac ccgataaaca tgatccacct acaccaagcc agttagtgcc accacttact
     5161 ttttctaatt ctttataatt catttctttc atcataaaag ttacctcctt ttttacaaat
     5221 gtgatacaca agaaactgat ccgctaataa tacccacatt agcaccaaat atagctccac
     5281 ctactgtacc aattggagta ccaaatgcag tgcctgcaat gccatatttt agtccatcct
     5341 tcaacgctcc cattccaata gctttagcac aatttgtgat ttttctacgg cgtcttgctt
     5401 taccaccgtt accaccgaaa acagctgaca gttcttcata agttaaagtt tcaaatttgt
     5461 tcatgttttt cccctttata aaacttctaa ttacaatttt cataagtgaa ttaagtttta
     5521 cctctcttca acttacacac taataataca aaacaattta ccttcattgg cgtataatac
     5581 cgatttagca cgaaacaaga tctatttgga aaatatttac caaatcggcc aagttttcgt
     5641 atattagtaa tttacaaagg attcttatta attgttacgc taacttgata ttctgtttta
     5701 taaatccgaa aactagtaaa aacatagaca caatgcactt attatgagaa tggctaacaa
     5761 aaaaatcttc tcatagccaa ggctacaaga agattgccat cacattaatg cataaactga
     5821 tacgcacgct ctttacttta ataaaacatg atcaattata cgactataac atagccactc
     5881 aaaaccaaaa acttgagtcg aaatcaaata atcattttta gcatagtaac ctacgaaaaa
     5941 aatcacaagt ttcataggtt tctttgcgtt atcttctaag tattacgata ttttctattg
     6001 gagatatttt tagcctattc gcaccagtat ttttttcaat acttatctac tagttattat
     6061 ctacctctat gaaaagaact ttggaaaaac ttaggatttt ccaaataaac gtctcgttta
     6121 tgattaccac ctttcttact gtataaaggt agcatgtgtt cagtatcagt tagaccaata
     6181 tcatctacag aacctgaccc acctaaaatt ccgcttaaaa gtacttcatc tttagaaata
     6241 atgattcgtt tcatctactt ttcctcctta gttttctttc ctaatgaaat gcccaaaact
     6301 aaactgatta agatactaat cattccaatt aattgacccc agatattatc cttctcacct
     6361 gtagatggta aagactgagt agaaccattt ttaatagtgt cattttccaa tcgctttaac
     6421 ttagtaattc tattttgatt gttcttaacg gcactataag gcttgctttg cacttttact
     6481 gaatcaaatt gtttattttc tttcacactt ccgtgttttt cactaactgc tgctagaata
     6541 atattctttt tatgcgattt agctgttttc ttgaccttag tggctacgat tttaggtttt
     6601 actggcttct tcacagtttt cttcttagtt tcagctctag gagccgcata ctcttgatta
     6661 cctgtcgtaa ctttagtcag atctgcagta gagctagcaa catttgcagc attctcaaat
     6721 acgctatttt caacaaagtc agtaatagca acgtcattgc tagactgtgt ttgatcatct
     6781 tcagctacag tcacttcagg tatttcatta ctttcagatt cagtagtatt atcatccttc
     6841 ggttgatcct taattactgc ctgttccact aatttattag ctgcatcaga atacaaaaag
     6901 ttatataact cttgtcccgt cttttctcca ccgacccatg cactaataat ttttccatta
     6961 ataaatctca ttgtagttgg agtacctgga ataccaattt ctttgaaggc atactcatgt
     7021 gctccttctt cagcatcaat attgaaataa agcagcttac ctttaacgat ttcattgaaa
     7081 tcttttaaat caggtgaaaa ttgtcgacag tagtaacatg ttggacgacc gatatacata
     7141 agatgttctt gattattttt ctctgctaga agatctttta cttcttgcat ttttactcta
     7201 tgaaaatctt ttacattgtt ctcataatct tcaacagata cctcatcttc atcatcttca
     7261 ctatcttcct catttgcatt attaggatct tgattattag tattctgtga ctgattattt
     7321 tgatcttcag aagctgctgg ctcttcttcc tgcttatttt gagtttgagc tgcttcgttc
     7381 ttactactag ttttctgctc agattcggaa acatttttat catcattttc tgttttagat
     7441 actacttcac ttttattctc ttgagaagta ttaccttcat ccgcatgcac aatagtacta
     7501 ttcatcatca ataatactgc tgggctcaac attaacatta atattttttt cttattcata
     7561 gatcttcctc cgtatttttt ataactaaga aaaatatatc aattatcagc tatctttttg
     7621 gttatcagac ttattcagta cactttttga ccaaatcagt tatcaaaata attggaattt
     7681 gattctaact aaaaaagagc ttttcagctc cttttaattt tggttaagaa ttttatcctt
     7741 aaaatattca aaatatgtac tcttacctgt aataatagtt gcgttgcctt ccatcccata
     7801 tttcaaattt ttcttggact tggccttaca gattacttca tagacattat ttccgcgtag
     7861 attaatggga tatactccaa tttctttcac ttttcctact aatctatcca ttgttccact
     7921 agcattagct acctgaaaat acagtgtttg gccttttttt attgccccaa ttttattacc
     7981 tgggaaataa gtaactacat tgaccgttct tttagcctta atcatcggaa acaagtgaac
     8041 tgtattctcc tgtttatcat caagatgaac tagccatttt tctctatttc ttctaacaat
     8101 ttgtccttca tgatagtttc tattggcaat attaagtgta ttttgtggtt ctacaattcc
     8161 ggtagatgta actgtacttt gtctagttgc aaagaaagaa ccgactatta agatcagaac
     8221 taaaattgcc ataggaataa taatcatagt tgaaaaattc ttgaatttat aggaatagta
     8281 ttcggtactc tcatagtctt tattattcat aacgttgctc ctaattctca actaagttat
     8341 agtaaaagcc atgtttctgc attaatttct catgacttcc ttgctcaaca atttgaccat
     8401 gatctacaac cacaatattg ttagtccttt gtgcaattgc taaacgatga gcaataaaaa
     8461 taatcgtttt atcttttaat ttcattaaat tatctactac ttttttctct gtaatcgtat
     8521 caagcccgct agtggcttca tcaaaaatta aaattttagc cggtgacaat aatgcacgtg
     8581 caatagttag cctttgcttt tgcccaccgg ataaaatctt ggcattttca tccatcttgg
     8641 tttcaaactg cagtggtaat tgttcgattt cagactcaat ttctgctatc tgacaggctt
     8701 tcaatatatc tttttctgta atatctggtc gactacctaa gagcagattt tctttgattg
     8761 ttcctgagaa gatgtatggt gtttggggaa catagtttac gtatgaccgt aagacatgct
     8821 tatctacttt agtagaatta aatccattaa aagttaactt gcctttgctt ggagagaaga
     8881 aatcaactaa aagtttgacc atagtagact tacctgagcc actcatccct acgattgcca
     8941 acttatcatt gggttcgatt tttaaattaa tatctttccc ggatttaaaa ttgaagtgca
     9001 acactaagtg ttaaacaaaa aggccatgaa gacctaaact tgaagtgacg aaaaatcaag
     9061 aaaggaagat cttcatgacc aattcaaatt ctagcatttc taagcactat catcaattaa
     9121 ccagcgtaca acgtggacaa attcaagcaa tgctggattc cggcataact tcccgtactg
     9181 ttatcgctca agaagttggc tgccataagt cgacaatcag tcgcgaaatc aaacgcggaa
     9241 gcgtcctgca aagagacagc agctatttat tgtatgagca ctattacgct gatactgcac
     9301 agatttatta tgagaagcgt cgcaaaaact gctatcagcg caatccattg aagcattatg
     9361 ctgtcttttt gagaatgctc tccagacgct ttaaagctaa atttgatgcc accagcatcg
     9421 atgagttcgt tggtgaattc aaaaggacta tgccaggcta cccttgtccc agcacaccaa
     9481 ccgtctatcg ctatattgat cagggcttgc tggacataag caatattgat ctgcctatga
     9541 agctcaaaag acgcaggaac aagcgtcatc acagccatgg cggtcacgct ttgcacaaga
     9601 agcatcttgg caattccatt gaacagcgtc ctaaagagat tgaagacaga aaaacgccgc
     9661 tgcactggga aggagatctg gttaaaggcg tcagacgcaa gaatcagcct gctttaatga
     9721 ctttgaccga aagaaccaca cgctttgaag tagttatcaa gattcctgac tatcgggcaa
     9781 gcacatgcca aaggctgctt caaaatgaga ttgacagaca tcctgcctgg tttaaatcga
     9841 tcacgtttga caatggctct gagtttgcgg atatgaccaa gatcaaaggc tgccagatct
     9901 acttcgccca cccatattct ccatgggaaa gaggcaccaa tgagaactgc aatggacttc
     9961 tgcgtcaatt cttccctaaa ggcaaaagca tgaaagataa gtcagctgct tatgttcaac
    10021 aggcaactga tgccattaac cacaaatatc gccgaatcct ccaatatcac acagcagagg
    10081 aactcttcaa gcaatatatc tcttcataac ctaactgttg cacttaattt gacaattcag
    10141 gaattaatat cttttaatac atcgactcca tagccataat gatagtcaac atgatgatat
    10201 tcaatctcac ctgctaattg cttggcatcc ctaatctgag catctttctg gaactcactc
    10261 ttaaccatgt atacttcatt caatcgattt tgtgctacat tagctgattg tagagttggt
    10321 tgaagattaa taatgctctg aagtggatct acaaaatacg atagtaatgc gttgaaggtc
    10381 attaattgac caatgctcat ctgcccgttc attacaacct tagcccctac ccagaggata
    10441 attacattga gagataactg aatgaaggtc tttaaagctg actgcaaaga ttcagtttta
    10501 ctgtaacgaa aagatttctt gaggtaatcg acgaattgac tatcaatctt acgataacgt
    10561 gtttgttcgc tatttaaagc tttgattgtt tcaattcctt gaatatcttc aattactgaa
    10621 gaacttaaga cagcattact ctccatctga tcattattca tcttttcaaa tttcttagaa
    10681 aagctaagaa tcaccactgc ataaattggc aaagacagta gagtaatcac aaatagagtg
    10741 gaattttgaa ttgccaaaac tattcccatc acaattacaa ttgaaagatc aagaaataat
    10801 gaaataactg tactggcgag tgcgtcaata attcgactag catcagagaa ccttgaggta
    10861 atttcccctg ttctacgagt tacgaagaat tccattggta attcaaaaat atggcgaatg
    10921 tattgtaagt taagatcaat acttaatcgc tgacctagaa catccaatag aaaattttgc
    10981 ccgtaagaaa agatagagtt gaaaacatat gctatcaata aaccaatagc taggatcgac
    11041 aaagtttggt atgtaccgct aggaatataa gtatcaatta agccttgcaa gaagtatgag
    11101 ctacaaatac taatgattgt catcaaaaga gcagccaaaa taatattagt gactagtttc
    11161 ttttgtttga acatgtatgg aaatagtgac cacagatttt gctttttctc tttgagtggc
    11221 tcaaaatcat catttgggac cataaaaagg gcaattcccg tccattcttg agaaaacttt
    11281 tctttagaca ttttcgttaa accaacgcta ggatccggat cagcaatcac taaataattt
    11341 ttggttgcct taatcacaac ataatagtgg agtaattcgc cttgctttaa gacgtgtacg
    11401 atgaaaggat attgaatgtc tgcatcagga tcaaacaagg acatgtcagc tttaactgct
    11461 tcagttttta gattaaatgc ttgtgctgtt ttaactaagc ccagagcggt agtcccttct
    11521 aaattagtgc gggctgaatg acgtaaatgg gctaaaaata ctctagaatg atatttttta
    11581 agaatcatag ctaagcatgc aactccacaa tctgattcgt ctacttgtgg tacataaatt
    11641 gatttatact gtagtaacat cttttccact cctcatatta agttgaatcc attatttcat
    11701 gattggaaaa ctaaatgtaa aaaaatacca aatcggttat tctcattacc gattcggtat
    11761 tttagttttc taactagatt gagctactca actttaatat tttcaaattt atctacaagc
    11821 tttttaacca cggctttata cgatctagaa taagttacca tctgaccatt atcaaatata
    11881 ataatgcgtt ccttcgtgtc aattgcacta atgttcttag gatttaccaa agaagattgc
    11941 gaaacttttg ccaagaatgg gttttcttta tcaatctgag taatatttgc cttatactca
    12001 acttctccat tctcagtaac catatgtact ttatgctgtg tagtactgtg ttcaatgaaa
    12061 agtatatcgc cttcggccac tttacatacg cgccgaccaa tcttataagt aaagtcacgt
    12121 tgactaaact taattctgtt agataaatta tcgaaggcgt tacgtaacgt ttcttcgata
    12181 cgttgaataa tcttatcaga cgacatagac ttactaatat aatcaattgc accgatacga
    12241 cggcgatacg ttaatggagc gtacttatcg tacgccgtta cgaagatgat ctgggcattt
    12301 tcgtcattct tcttgatgaa ttcagctaaa tctacgccat tcttagcttt agactctcga
    12361 cttaattcaa tatctaagaa gtagatacca ttcttaatat catttgtgac tatgtatcct
    12421 accgcttgag caaaatcgtt agcaacaaac gtaacagatt catttaattc agcgtaacct
    12481 tcattatcat ctattaagtc ttgaatagat gcattgatat tcttagcaat ctgattagct
    12541 aaatctttat cgtcatcgca tacaatgatt gggaacttac tcatcctctt caccatcttc
    12601 cgtatcaatt gtcatataaa agtcgaacca gccgtcttga attgtataag aaatagacat
    12661 atcaggatat ttactctcaa tttccttaat attagctaat ccaagccctt tatggtcttt
    12721 cttagtagta aagccacgtt gttgaatttg actagttgag atatttttat tttggatttt
    12781 atttctgatt tcgaactcaa attcatctgg gtcatcagaa tagaccatta tttggacttc
    12841 agcacttcga atatcatgct tttcggcaat caatgcttta ctttcctcaa ttgcattatc
    12901 gaaagtaatg ccaataatac gtactagatc gagttcatct acatggtctg gtaaattacg
    12961 gatattattt cgacattcaa aattatatgg tatatccaaa ttatacaatt ctgttatctt
    13021 tggaataata atgctcttaa ttgatttaac gtaaatgtga tttaggtctt tatatttaag
    13081 taaggcttta gaatttaggt tagtttcagt atatttatct agtttctgaa ttacttcttg
    13141 aacgttacct tcttgcgcac ttacctttaa agaattaaga atatttttgt aatcatgtct
    13201 gaaggcgcga agatcatctt cacttttttc aagataagaa gcatattctt caagctgatg
    13261 ctgctgttgc tttaattttt cttgatcctt tttatttaaa agtttttctt gtaccatcgt
    13321 catttcatga tatataaata tagcaaaaat agtttggata agaatataga gagaaaagaa
    13381 caaagttaat ggtgtaaaag atttgctttg aatatatatg atagagatgc tcaccgtaga
    13441 aacataggta taagctaata tgcctacgaa aattttatta ttttggtttg ctagataatt
    13501 atatattttt ccattaccta gttttattgc aactatcatc attagtatta gtaagaaacg
    13561 tagtgataat tggcctatca aagtaaatga cataacctga gtgatcatat cagacacaat
    13621 atcaactaat aaatctaatg tgcatactaa tattattgaa ccaaatagta tttctaatgt
    13681 attatttttt ctcaaatata atacaaaaag caaagtttcg aaactgtcaa atcttttgtg
    13741 taaatagttc tttctcgtaa attgattttt taattattta tttaatcaaa gtaggattct
    13801 aaggtgtcct gaacctgacc aaagccttta tgaattcgat tgaaataacg gtcattgtag
    13861 ctcattgcct gaatgccaat aaaagcatca agcgactgtt cagttggaaa ctctgcctta
    13921 ggcttagctt tgcgcttgat cacattgtta aatgattcaa tcatgttagt cgaataaatt
    13981 gaagctctga tctgcttggg atagttataa aagaccagca gatctggttc tatgtctttc
    14041 aagcttctga taacatggct gtaaaccttg ccccatttgg tatagaagtc atgcaggaca
    14101 gctgtggctt cttctttgtt tgtctgttga tgcacctgtt tgaattcgtt catgatcttt
    14161 tcgcggtcat ccacccggac tttagcacag atattgcgca tgacatgaac caagcagcgt
    14221 tgaaaatgag ctttaggata agtcctggtc aaggccgctt tcatgccaac aacaccatca
    14281 gaaagaaaga gctcaacttg cttcaagcct ctggacttca tgttttgaag catctctgtc
    14341 cagacttcaa tgttctcact aggcgcaatg cagtagtcaa tgacttcttt atgtccatta
    14401 ggtttaatgc caatggcaat atagactgct tcacgctcaa acgtttctcg gcgcaaagga
    14461 aggtatgtcg catccaaata gacacagaaa aacttgtcgc ttagcttgcg cttgtgataa
    14521 gcctcaacct tggggagcat ctgcttggaa atatttgata cttgggctgg actataatga
    14581 ctgccataca ttttctcaat caagtcagcg atttccctgg tggtcacgcc cttggagtaa
    14641 agcttgataa tcatgctttc caagatatcc gagtgctgct tgtagtcagg cagcgtgtgc
    14701 tgatgaaatt gaccgttgcg atcccgaggc acttgcactt caattgggcc aaattgcgta
    14761 tcaactttgc ggaaataagc accatttcta gagttgccag tattccagcc atttctggca
    14821 tagggatcat agcccagaaa ggcagtcaat tcagcttcta gcaagttatt aacagcctgt
    14881 tgtagttctt tgcgcaataa atcatttatt ttgtctggat tgaatagagc ttgagcaaaa
    14941 tctttggtaa aatcattcat gaaggagttc ttctttctgt atgtgttttt tttgttcaaa
    15001 ccaatcatac gagaaaggaa ctcctttttc taatgtttaa agaaataaat ttaaggaatc
    15061 attcatcctt acacaaacta ttttacagtc tcaaagtttc aagtatattt gtgaagatta
    15121 cgccaatatt acctatagac aataacaacc ctaaaaaaat attagcaata cacaaaaata
    15181 gaatctgtct ctttttagat cttactcttg atatttaaaa aaaacaccat acatctgcta
    15241 aactagaaaa aacattaaga aaaagaaata agactatctt ttccatatat tattccaaag
    15301 ttttttactc aagaaattaa aaccaacatg tgccgtgctt ccaccaacaa ccttagtcaa
    15361 ttcttcttcc ttcaaaacag tctttttaac attttgcttc ttcatgatat ttcatccttt
    15421 catgatttta tactcaactt gtttacacct ttaatatatc atgtactttt aagtaaatta
    15481 aaaaagatac caattcagtc atactttcgt accgatccgg tttcatattt cttcaaacgt
    15541 aaacaactga caattaattt tcttagctaa ttcctgacag ctatccgtaa agccagattt
    15601 ggaaaataga taataatgct taagtggata cttgaagatt tcactatttg taatcaattt
    15661 ttctaacaca ctacgagaga tcggttcatt cttccattta cattcgccga aatatccatc
    15721 acgttcatcg tcagagaatc ctacaatatc taactcaact tgttgatgtg ttctcttatc
    15781 ggttccccac caattgccca agtggataaa cggattagga acaatttttt cattcatatc
    15841 ctgagaccac atgaagtctt gactgtattt ttcaaactca ggtcccatga aatcagatag
    15901 acccttttgt acttttaccc aagcaagatc agttaagcca cgctcaatta gatcggtttg
    15961 cttgccaaca aaggtatacc agaagcggaa catcccgtca cagatacgat aaacgatatt
    16021 tttgctttta ctcttctttt gctcagtaac cggtaacttt ttctcaacaa tacctaaatc
    16081 tatcaaatta ttcaggtacg tggttagcgg accagtttgt aagtgggcgg attgcgcaat
    16141 tttactatgc ttagaagcac ctgaagctat cgcattgata atcgaattat agttagttgg
    16201 atcgcgtaat tcctgttgta acaagttatt aggctcatca aataagcgac ctgatttact
    16261 caaaaagttt ttcttaatat tatccgcaac tgacatgctg tctgacatat aactcaaata
    16321 ttggggtaca ccgccacaaa ccgtattgat gataaaagcg tcctctttac tgagttttgg
    16381 taacatttca tgtgcttctg ataatttaaa tggttcaagc tttaaggcta aagtgcgacg
    16441 accatatagt ggactttggt agcctaagac ttgtcgttcc ataaatgaca tcgatgaacc
    16501 acataaaatc aaaaataggt tagtttcttt gaattcatga tcaatgtagg attgcaacat
    16561 tgaactaatt gtagggtaag ccttagccaa ataaggaaat tcgtcaataa ctaaaattac
    16621 acgttgtttt tgagctaggt gtgtaatttc tttaaagcat
//
