LOCUS       c00101_JACCPT0..       12841 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JACCPT010000063.1 Lactobacillus crispatus strain LB61 Contig_63,
            whole genome shotgun sequence.
ACCESSION   JACCPT010000063
VERSION     JACCPT010000063
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2022-06-21 13:31:11
            Original ID  :: JACCPT010000063.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12841
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12841
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[6391:8926]"
                     /cutoff="10000"
                     /detection_rule="(Amidinotransf and OTCace and OTCace_N and
                     AA_kinase)"
                     /neighbourhood="10000"
                     /product="Arginine2_Hcarbonate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      6392..8926
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Amidinotransf and OTCace and OTCace_N and
                     AA_kinase)"
                     /neighbourhood="10000"
                     /product="Arginine2_Hcarbonate"
                     /protocluster_number="1"
     cand_cluster    1..12841
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Amidinotransf and OTCace and OTCace_N
                     and AA_kinase)"
                     /kind="single"
                     /product="Arginine2_Hcarbonate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12841
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Arginine2_Hcarbonate"
                     /region_number="1"
                     /rules="(Amidinotransf and OTCace and OTCace_N and
                     AA_kinase)"
                     /tool="gutsmash"
     CDS             3..494
                     /locus_tag="ctg101_1"
                     /transl_table=11
                     /translation="VVGMKTALARTYPKAHFQRCLVHVMRNICAKVRVDDREKIMNEFK
                     QIHQQPNKEAAIKVLHAFYDKWNRAYNHVIRDLKEIEPDLLVFYSYPKQIRASIYSTNM
                     IESFNNVIKRKAKPKAEFPNEQSLDTFIGIQAMSYNERYFNRIHKGFGQVQDTLESYFD
                     "
     CDS             complement(770..1810)
                     /locus_tag="ctg101_2"
                     /transl_table=11
                     /translation="MPGIVEQTLLEQQNIDLNEMVTMNQMIDQLLPNASKELQQKLKIK
                     IYNFVRTRKQPSITVRRRKYFKPAVAKLIIGNVQDYADAIERRAKEAPAKEDATDKRPA
                     SKSKRVKTITKRKILAKVIKNDKIDKSIQKKLEDKIASIVKTNFIKPVNKRGSFSVEDG
                     EKVIAELSPFYQNIKIDQKYRKNAEKAAENKETETKEKPEQHSKDQNESREGQSKDFER
                     KNNQKNSNNRNNNNQTQNQRKRQNKHPFEIRRENNNRSRNNQSNRRYNNRNNYDNRNNY
                     EFDEASGLRERYNTVIRNYNQLEQRYNALQDKYNQALDDKARLIEEMGKKNEDLRRVLI
                     DVLRKM"
     CDS             2154..2282
                     /locus_tag="ctg101_3"
                     /transl_table=11
                     /translation="MKGMRTLIKLLLIGGSFLTLGLMAISSVLINKPAVAKVKHRH"
     CDS             complement(2380..3072)
                     /locus_tag="ctg101_4"
                     /transl_table=11
                     /translation="MTKLILGGEVMKLKQTPILRLYKLETNKEDHAKFVKAGQHNMLTS
                     QENEPGTLFMQTSHDEETTNFVVECYQDEASYDTHANSKQFKDFTDVAKDILTSRVKVE
                     LFPEFISTKAEKLAVTGSNDYVIYLTEIGVSLGKGDEFAHAVMKEMKTAVEEEKDILAM
                     IAGTVADQPNEWLAIEVYRNNEAYKQHLETKNFKEYLNNTKYCVESKSLRKLQPDVIVD
                     QGAIFYQP"
     CDS             complement(3138..3644)
                     /locus_tag="ctg101_5"
                     /transl_table=11
                     /translation="MVLVLGLTGLASQVETVDASTYGNGVQVTIPKKMQGTWYSYDRNA
                     HNGTKITFTEHTVNGKPIFTQEASTISDYFNGRIANQKNFDKVTQNWMSGKTTKMKNDT
                     FYEIDPWITFENWSLYRVVPQTINGKKHNVLVYSSRYDGGNYFRSKKLAKKMKDYKFKK
                     VNYTL"
     CDS             complement(3610..3720)
                     /locus_tag="ctg101_6"
                     /transl_table=11
                     /translation="MKADSYILHSGDDFYAKKNFVTFNINGTCFRINWFG"
     CDS             complement(3776..4381)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg101_7"
                     /sec_met_domain="LysR_substrate (E-value: 1.6e-12,
                     bitscore: 37.3, seeds: 361, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTELKIAYFDQLGRKELDQAVQHFVLKHPNVDVKLLATSHDGAFA
                     KLNEDEADIAINDLRDENLNFDETELTQAGVMAILPKGMYPNGIQMIEKDELNDMTCFI
                     VAKPEEEVSELHLFKDLYQIGSQFIASNSVEEAALLVASRSGYFILNENTARLINTTDL
                     QPLFLLDHGQLIKQKIMAFYKSNSALSSEFIKLLQQEY"
     CDS             complement(4383..4544)
                     /locus_tag="ctg101_8"
                     /transl_table=11
                     /translation="MSKEKKLNLIKLFGIVVSGLNLIFFALMALNKHEDTKDKRRVAEE
                     GHAPLDEK"
     CDS             complement(4560..5762)
                     /locus_tag="ctg101_9"
                     /transl_table=11
                     /translation="MNKFIDVRIGISMELKKNKNNLKQITALIQYAFLKNNDLTKDENF
                     MSRYDHSTGYGYFDKEKLASYIMVNRFKSDVFGHHLPMAGIGYVASYPEYRGQGHISQL
                     MKEILHDLHRQDIPFANLAPFSESFYRQYGFSNSIYQKEYRFDGSALRSFKLPRSGHIV
                     RGKWDNLAVQNGVIQLYERQLHTDDERNTVVREAWWWNRLDSYYHHRNVAVYFDADERP
                     ISYLIYRIRDNTFLADEMYAITPQGLLSMFGFMGSHAGSVKQFKMSVPEKSLRAELFPE
                     QNELQVDLRPYMMSRIIDFEKVLACMRPMQEGDFNLEVNSDEQCPWNIGVWQLSNHGRK
                     VAVERKEDALVDFSGSITAWTQVLLGRLTMNAAVKLGLITDYRIKKLDFVKGDVSFYDY
                     F"
     CDS             complement(5842..6378)
                     /locus_tag="ctg101_10"
                     /transl_table=11
                     /translation="MNIFNEGKKQDIAQVLAAKDRRVAVQHKIFNKYPNQTLVDINMNI
                     PGPIKNNRYLTKMFMLGINELENAWTNLGYHFKLVTQLNDDSGCENFYVLSLSIEKVKR
                     STIDFENQISLGRLFDADVLVKNKQAAISRRDLGRQPRKCFLCDRPAKECARSRRHSVE
                     QMQAFISQLYQEYVA"
     CDS             complement(6392..7294)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: AA_kinase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: OTCace"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg101_11"
                     /sec_met_domain="OTCace (E-value: 5.2e-47, bitscore: 149.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /sec_met_domain="AA_kinase (E-value: 2.5e-20, bitscore:
                     63.1, seeds: 128, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VGDGRDNVADSLLVCGSMLGVNVHIVTPKPLFTHPDVQKIAQNFA
                     QDSGSKNLITDDIAQGVKGANVVYTDVWVSMGENDWSERIKLLKPYTVTMKMMQMTGTP
                     DDQLIFMHCLTAFHDRTTQVGEEIYEKYGLNEMEVTDEVFNSKYAWQFTEAENRLHSIK
                     AVMAATLGNLFIPIACGGGGILVIVKDGHLRGVAGVIHKDFSAAKMAEDINADELVILT
                     TVDHAFLNYGKENQQAIGKIKVEQLKQYLAAGYFAAGSMKPKIEAAIEFVEKTGNLAII
                     TSLSNANKLADGVGTIIYN"
     CDS             complement(7255..7686)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: OTCace_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg101_12"
                     /sec_met_domain="OTCace_N (E-value: 5.2e-38, bitscore:
                     120.5, seeds: 1463, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYLQNVFQGRSFLDCKDYTPAEISYLIDFALHLKELKKEHIPHE
                     YLKGKNIALLFEKASTRTRSAFVVACNDLGAHPEYLGASEIHLGKKESVKDTAKVLGSM
                     YDGIEYRGFAQEDVEELAKYSGVPVWKWVMAAIMLPTVF"
     CDS             complement(7697..8926)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: Amidinotransf"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg101_13"
                     /sec_met_domain="Amidinotransf (E-value: 2.4e-109,
                     bitscore: 355.5, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSPIHVYSEIGKLKTVMLHRPGKELENLAPDILHRMLIDDIPYL
                     KIAQEEHDAFAHVLRQQGIKVLYLEDLLAESLTDEKVRRAFLDQLLDESSIKKQDPLHQ
                     LLLNYLQELLTKEMVKTVIAGIRKSAIHNSTPSLADLAEDPDYPFYLDPMPNVYFTRDQ
                     QAAIGSGMTINRMTFRARRRESLFMETILKNHPDFKNATIPVWRDRYHHGRLEGGDELV
                     LNNHVLAVGISQRTSATAITDLAHNLFDHSSYDTILAIKIPHNHAMMHLDTVFTMINYN
                     QFTVHPFILDKAGKIDIYVLQPDDHNGVKITEKNDLVQVLKENLHLSELDLIPTGGGDP
                     IAAPREQWNDGSNTLAIAPGEVVTYDRNYVSNDLLRKHGIIVHEIRSSELSRGRGGPRC
                     MSCPLIREDL"
     CDS             complement(9000..9848)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     75.6; E-value: 7.6e-24)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg101_14"
                     /sec_met_domain="LysR_substrate (E-value: 4.2e-30,
                     bitscore: 94.7, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 2e-24, bitscore: 75.6,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLKQLRYFLVVAEEKQITAAAKRLYIAQPPLSYQLKQLEKELGA
                     QLFKRTAHGIELTDVGQIFQSYANEIISLAQNAENQVHKTISGELGTIAIGMASSSTGL
                     IPMNSFNELRKYYPEISFDIYEDNTYGILDKLEKKTIDLGIVRTPYNQTGLNTKTLTTE
                     KMMAISVDPDFQQKKELRIKDLADQPLIIYRRFEDIFNQTFAHHGLKPFYAVKCDDSRT
                     AITWAKRKMGVALVPESIATTYAQENMIAIKHANWITHLQLVWRKDHQVTPLMKKIIAA
                     I"
     CDS             9977..12250
                     /locus_tag="ctg101_15"
                     /transl_table=11
                     /translation="MSDKFHGLTQAEADKRLKEDGLNEVPEPEYNFFKEFLSKLWNLSA
                     WILEAALILECILGKWVQSLFVLLMLLFAAFNGASKKKQSRRVLNNISHKLTPTVSVER
                     DGKWIKLDSKQLVKGDLISLKRGDVLAADVKIVDGNLACDESSITGESKPVKKAIDDTA
                     FAGTTVVEGDGLAVVTATGKDSRSGKTINLINNSAAPGHLQQLLTKIIYYLCLLDGVLT
                     LVIIIASFFKGGNFNTFINMLPFLAMMFIASIPVAMPSTFALSNSFEATRLSKEGVLTS
                     DLTGIQDAANLNLLLLDKTGTITENKTAVAAWTDLSDLPDKDVLALAGAATDKRNAGII
                     DTAIDEYLVENNIPVMNAENFTPFTSDTGYSMADVAGHNVKLGSFKQLSLIDKHADEEI
                     SGINFKAGRSVAVLIDDKLAGVFILQDKVRTDSKAALAELKKRGVRPIMLTGDNQKTAA
                     AVAEQVDLTGKVISIHDFNENTDINDLAGIADVLPEDKLKMVKLFQEKGYIVGMTGDGV
                     NDAPALKQAEVGIAVSNAADVAKRSGKMVLLDDGLGSIVKILDAGHRVYQRMTTWSLTK
                     LARTAELTMLLTFGYLFFDYIPMALNAMVIYTIMNNMVTMMIGTDRTHITYKPENWNMA
                     KLAKIAFSLAAGWTLIGIGFVWFLNTHGWSHGAVSTMVYVYLVLSAMLIVLITRTRKYF
                     WQDYPSKLVGSVQIADVLLTFILALCGWAMVQISIQNLAITVIVAIIAAIIIDLIYQPV
                     MKNR"
     CDS             complement(12318..12632)
                     /locus_tag="ctg101_16"
                     /transl_table=11
                     /translation="MKRCKNWVVTIVAFLMLVGEISVLPANLQGSTSVVNAAIHHRRRK
                     HQYRDKTKIYTSNYRIVDNKRSKIFHVMRGHNYRMNRENAVFFKSKAAARAAGYRESKR
                     "
ORIGIN
        1 gtgttgttgg catgaaaaca gccttggcca ggacttatcc taaagctcat tttcaacgct
       61 gtttggttca tgtcatgcgc aatatctgcg ctaaagtacg cgtcgacgat cgtgaaaaga
      121 tcatgaatga attcaagcaa atccatcaac agccaaataa agaagctgcg atcaaagtct
      181 tgcacgcctt ctatgacaag tggaacagag cgtacaacca tgtcatcaga gatctcaaag
      241 agattgagcc tgatctgctg gtcttttaca gctatcctaa gcagatcagg gcttcaattt
      301 actccaccaa tatgatcgaa tcctttaaca acgttatcaa gcgtaaagct aaacctaaag
      361 cagagtttcc aaatgaacag tcgcttgata cttttattgg cattcaagca atgagctaca
      421 acgaacgcta tttcaatcga atccacaaag gcttcggtca ggttcaggat accttagaat
      481 cctactttga ttaaataaaa gattaaaaaa tcaatctacg agaaaaatct atttacacaa
      541 aagatttgac agtttcctcg aaacacattg cttttaaata gctcttttaa actcatactt
      601 ctcctccatt aatcattaat aaaaatattt atcatccttt aatcttacta cacaaaaata
      661 attttttaca catatttttt taatttttaa gctaaatcat atttcataaa cataaaataa
      721 gactagtaat caattcaaat tgactactag tctctttgtt taccaaaaac tacatttttc
      781 gcaaaacgtc gatcaataca cgacgtaagt cttcgttctt cttacccatt tcttcgatca
      841 atctagcttt atcatctaaa gcctgattat atttatcttg caaagcatta tatctttgct
      901 ccagttgatt gtaatttctg attactgtat tgtagcgttc acgcaaaccg ctagcttcat
      961 caaattcata attattccga ttatcataat tatttcgatt attatagcgg cggttagact
     1021 gattattacg tgagcggtta ttattttctc ttctgatctc aaaaggatgc ttattttgtc
     1081 gcttacgttg attttgcgtt tgattattat tatttcgatt attgctattc ttctgattat
     1141 tcttacgctc aaagtcctta gattgacctt cacgactttc attctgatcc ttagaatgtt
     1201 gctcaggctt ttctttagtt tctgtttcct tattttcagc cgctttttca gcattcttgc
     1261 gatacttttg atcaatcttg atattttgat aaaaaggact aagttcagct ataacttttt
     1321 caccatcttc aaccgaaaaa cttccccgct tgttaactgg cttaataaag ttggtcttca
     1381 caattgaagc aatcttatcc tctaatttct tttgaataga tttatcaatc ttatcattct
     1441 ttataacttt agctaaaatc ttacgcttag taattgtctt aacccgctta gatttagaag
     1501 ctggcctctt atcagtagca tcctctttag ctggggcttc cttagcacga cgttcaattg
     1561 catctgcgta atcttgtaca ttaccaataa ttaatttagc aacagccggc ttaaaatatt
     1621 ttcttcttcg cacagtaata cttggttgtt tacgtgtacg cacaaagtta taaattttaa
     1681 tctttagttt ttgttgtaat tctttacttg cattaggcaa caattgatca atcatttgat
     1741 tcattgttac catttcattt aaatcaatat tttgttgttc taataatgtt tgctctacta
     1801 ttcctggcat ttccaatcct atattctttt aattttttca caacaaaaag ggccattacg
     1861 gcctattttg caataataca tcaattttct cattaataaa cttaatgcac tttccatttt
     1921 acaacattaa cgctatttac gaaaagggct acaagcatat tctctatttt ttaaccaaaa
     1981 caagcagcat cccatcgata ctgctttatt ttatgcgcag ttgcactaga ctttgactct
     2041 atttctattt tacgtgctaa ccagcctttt ttctagtttt attttcttaa ctaatccatt
     2101 aggttttaca tataaattct taatattatt tcgctattat aagatcaatt aagatgaaag
     2161 gaatgagaac cttgattaaa ctactcttaa ttggtggatc atttttaacg cttggtttaa
     2221 tggccatcag ctcagtatta attaataaac cagcagtagc aaaggtaaaa catcgccact
     2281 aaaaaccaga ataatatatg ttaataaatc ttttcccctc taactagaaa gaccaggtta
     2341 tgtactccac atagcctggt cttcttttcg tcttattctt tatggttggt agaaaattgc
     2401 accttggtca acaattacat ctggttgcaa cttacgtaaa ctcttacttt caacacaata
     2461 ttttgtatta ttcaaatact ctttgaagtt cttagtttcc aagtgctgct tgtaagcttc
     2521 attattacga taaacttcaa tagctaacca ttcatttggt tgatcggcaa cagttcctgc
     2581 aatcattgcc aaaatatctt tttcttcttc gactgccgtt ttcatttctt tcattacagc
     2641 atgagcaaac tcatcgccct tacctaaaga aacaccaatt tcagtcagat aaataacata
     2701 atcatttgat ccggtaactg ctagtttttc tgcctttgta gaaataaatt ccggaaacaa
     2761 ttctaccttt actcgactag ttaaaatatc tttagcaacg tcagtaaaat ccttaaattg
     2821 ctttgaatta gcatgagtat cataacttgc ttcgtcttga tagcattcta ctacaaaatt
     2881 agtagtttct tcgtcatgac ttgtctgcat aaacaatgtg cctggttcgt tttcttgaga
     2941 agtaagcata ttatgttgcc ctgccttaac gaactttgca tgatcctctt tattagtttc
     3001 tagtttatat aaacgcaaaa ttggtgtttg ttttaatttc ataacttctc ctccaagaat
     3061 taattttgtc attattatac taaattttat cgcgtctatt agtaaaaaac atcccttagt
     3121 taagggatgt cacaaaacta taacgtgtaa ttaactttct taaacttgta gtccttcatt
     3181 tttttagcta atttcttgct tctgaagtag ttaccaccat catatctact agaataaacc
     3241 agcacgttat gctttttacc attaatggtt tgtggtacca ctcgataaag actccaattt
     3301 tcaaaagtaa tccacggatc aatctcatag aatgtatcat tcttcatttt ggtagtttta
     3361 ccagacatcc agttttgcgt taccttatca aagttcttct ggttagcaat tctaccattg
     3421 aagtaatcac taattgtcga agcctcctgg gtaaatattg gtttgccatt aacagtatgt
     3481 tcagtaaagg tgatctttgt gccattatgt gcattacgat cataagagta ccaagtaccc
     3541 tgcatctttt ttggaatagt aacctgtaca ccattaccat aagttgaagc atcaacagtc
     3601 tcaacttgac tagccaaacc agttaatcct aaaacaagta ccattgatgt taaaggtaac
     3661 aaagttcttt ttagcataaa aatcatctcc agaatgtaaa atatatgagt ccgctttcat
     3721 aatatatttt acagtatctt atagtactta gacaagatat ttttaacttt acagattaat
     3781 attcttgctg caatagcttt ataaactcac tacttaacgc tgaatttgac ttataaaaag
     3841 ccattatctt ttgctttatt aactgaccat gatcaagcaa gaaaagtggc tgcaaatctg
     3901 tagtattaat taacctagcc gtattctcat ttaaaataaa atagccagac ctagaggcga
     3961 ccaacagtgc tgcttcttcg accgagttag aagcgatgaa ttgactgcca atttgataca
     4021 aatctttaaa taaatgtagc tcactaacct cttcttcagg tttagccaca ataaaacaag
     4081 tcatatcatt gagctcgtct ttttcaatca tttgaatgcc attaggatac attcccttgg
     4141 gcaaaattgc cattacacca gcttgagtca attctgtttc atcaaagtta agattctcgt
     4201 cacgcaaatc attgattgct atgtctgctt catcttcatt cagttttgca aaagcaccat
     4261 catgactagt cgcaagtagt tttacatcta cattaggatg ttttaacaca aaatgctgca
     4321 ctgcctgatc taattcctta cgacctaatt ggtcaaaata tgcaatcttt aattccgtca
     4381 ttttattttt catccagcgg tgcgtgtcct tcttctgcta ctcttctttt atccttagta
     4441 tcttcatgct tattaagtgc catcaaggca aaaaagatca aattcaaacc actaactaca
     4501 atgccaaata attttattaa attgagtttc ttttctttac tcatttttta acctcacaac
     4561 taaaaataat cataaaatga tacatcgcct ttaacgaaat ctaatttttt gatgcggtaa
     4621 tctgtaatta atcctagttt aacagcagca ttcatggtta gtctacctaa tagcacctgg
     4681 gtccacgcgg taattgatcc cgaaaaatca accaatgcat cttccttacg ttctaccgct
     4741 accttacgtc catgattact taattgccaa actccaatat tccaaggaca ctgttcatcg
     4801 ctattgactt ccagattaaa atcaccttct tgcattggcc gcatacaagc caaaactttt
     4861 tcaaaatcaa taattcgact catcatataa ggacgcaaat caacttggag ttcgttttgt
     4921 tcaggaaaaa gttcagctcg taacgatttc tctggtacgc tcattttaaa ttgcttaaca
     4981 ctgcccgcgt gcgaacccat aaaaccaaac atactcagta atccctgcgg cgtaattgcg
     5041 tacatttcat cagctaaaaa agtattgtct ctaatgcgat aaatcaagta actaattggc
     5101 cgctcatccg cgtcaaaata aacggctaca ttgcggtgat gataataaga atcaagtcta
     5161 ttccaccacc atgcctcacg tacaaccgtg ttacgttcat catcagtatg cagttgacgt
     5221 tcataaagtt gaatcacacc attttgaaca gctaaattgt cccacttgcc acgcactata
     5281 tgaccagaac gtggtaattt aaaactacgc aatgcgcttc catcaaagcg atattctttt
     5341 tgataaatac tattgctaaa cccgtactgg cgataaaagc tctccgaaaa tggtgccagg
     5401 ttagcaaacg gaatatcttg cctatgtaag tcatgcaaaa tttctttcat taattgggaa
     5461 atatgacctt ggccacgata ctcaggatat gaagctacat aacctattcc agccatcggt
     5521 aaatgatgcc caaaaacatc acttttaaat cgattaacca taatatagct agctaatttt
     5581 tccttatcaa aatagccata acctgtacta tgatcataac gactcataaa attttcgtct
     5641 ttagtcaaat cattattttt caaaaatgca tattgaatta atgccgtaat ttgctttaaa
     5701 ttattcttat ttttctttaa ttccatgctt attcctatac gtacatctat aaatttattc
     5761 attactattt tagttcattt tttaaatttt taactagatt tttcataaaa ataaaccgga
     5821 atcataaaat cccggtttat tttacgcaac gtattcttga taaagctgag agataaatgc
     5881 ctgcatctgt tccactgaat gtctccggct acgagcacat tctttagcag ggcgatcaca
     5941 taaaaagcac ttacgtggct gcctgcccaa atctctgcgt gaaattgcag cttgtttatt
     6001 ttttaccaac acgtctgcat caaagagacg tcccaatgat atctgattct caaaatcaat
     6061 tgttgagcgc tttacttttt caattgacaa agataataca taaaagtttt cacagccact
     6121 atcatcatta agctgtgtca ccaatttaaa atgataacct aggttagtcc aagcattttc
     6181 cagctcattg atacccaaca taaacatttt agttaaatag cgattattct tgattggtcc
     6241 tgggatattc atattaatgt cgactagagt ttgattagga tacttattaa aaatcttatg
     6301 ttgtacagct actcgcctat ctttagctgc taaaacttgg gcaatatcct gcttttttcc
     6361 ttcattaaaa atattcattt ttatcaccca gttaattata aatgattgtg ccgactccgt
     6421 ctgctagttt gttggcattg ctcaaagagg tgataattgc taaattacct gttttttcta
     6481 caaattcaat tgcagcttct atcttaggct tcatactccc agctgcgaaa taacctgctg
     6541 ctagatattg tttgagctgt tcaactttta ttttaccaat tgcttgttga ttttctttgc
     6601 cataattcaa aaatgcatga tccaccgttg ttagaattac taattcatca gcgttgatat
     6661 cttctgccat tttagcagcg gaaaaatctt tatgaattac gccggcaaca cctctgagat
     6721 gcccatcttt cacaataaca aggatgccac caccgccaca ggcaatcgga ataaataaat
     6781 ttcctaaagt agccgccatc actgctttaa ttgaatgcaa tcgattttca gcttctgtaa
     6841 attgccaagc atactttgaa ttaaagacct catcagttac ttccatctca tttaagccat
     6901 atttttcata gatttcttct cccacctgag ttgttcgatc atgaaaagct gtcaaacaat
     6961 gcataaagat caattggtca tctggtgtac cagtcatttg catcattttc attgtgaccg
     7021 tatatggctt taataattta attcgttcag accaatcatt ttcacccatc gaaacccaaa
     7081 catcggtata aacaacattg gctcctttaa cgccttgagc aatatcatct gtgatcaaat
     7141 tttttgaacc tgaatcttgg gcaaaatttt gagcaatttt ttgtacatca ggatgtgtaa
     7201 acaaaggctt gggtgtaaca atatgtacat taacacctaa cattgagcca caaactaaaa
     7261 gactgtcggc aacattatcg cggccatcac ccacttccaa acaggaacgc cagaatattt
     7321 agccagctct tctacatctt cttgagcaaa accgcgatat tcaattccat catacattga
     7381 gcctaggact ttagccgtat ccttgacgct ttctttttta cctaagtgga tctcgcttgc
     7441 gcctagatat tctggatgag cacctaaatc attacaagct actacaaaag cagatcgcgt
     7501 cctagttgag gctttttcaa aaagtagtgc aatattttta cctttcagat attcatgtgg
     7561 gatatgctct tttttaagtt cttttaaatg taatgcaaaa tcaattaaat atgaaatttc
     7621 agctggagta tagtctttac aatcgagaaa acttctacct tgaaaaacat tttgtaaata
     7681 tttcattttt tgcctcttat aaatcttcac gaatcaacgg acacgacata catctaggac
     7741 cgccacgacc acgtgagagt tcactagacc gaatctcatg aacgatgatg ccatgttttc
     7801 ttagcaaatc attggataca taattacgat cataagtaac gacttcacct ggtgcaattg
     7861 ccaaggtatt tgagccgtca ttccattgtt cacgtggtgc ggcaattgga tcaccaccac
     7921 cagttggaat taaatccaat tcgcttaaat gtaagttttc tttcaaaacc tgcaccaaat
     7981 cattcttttc tgtgattttt acaccgttgt gatcatcggg ctgtagaaca taaatatcaa
     8041 ttttgccggc tttatctaaa ataaagggat gaaccgtaaa ttgattataa ttaatcattg
     8101 taaaaactgt atcaaggtgc atcatagcat gattgtgcgg aatcttaatc gctaaaatcg
     8161 tatcataact tgaatgatca aataaattat gagctaagtc agtaattgca gttgcagaag
     8221 tgcgttgtga aatacctaca gctaacacat ggttatttag aactagttca tccccgccct
     8281 caaggcgacc atgatgataa cggtcacgcc aaactggaat agttgcgttc ttgaaatcag
     8341 gatgattttt caaaattgtt tccataaata atgattcacg tcgtctagct ctgaaagtca
     8401 tccggttaat ggtcatccct gaaccaattg cagcctgttg atctcgagta aaatatacat
     8461 ttggcattgg atcaagataa aaagggtaat ctgggtcctc agccaaatct gctaaagatg
     8521 gggtagaatt atgaatcgca ctttttctaa ttccagcaat caccgttttt accatttcct
     8581 tagttagcaa ttcttggaga tagttcagca ataattgatg caaaggatcc tgttttttaa
     8641 tacttgattc atccagtaac tgatctaaga atgcccgacg aactttctca tctgttaaag
     8701 attctgctaa taaatcctca agatataata ctttgatccc ctgctgcctc aatacatgcg
     8761 caaaagcatc atgttcttct tgggcaatct tcagataagg aatatcgtca atcaacattc
     8821 gatgcaaaat atctggggct agattttcta gttcttttcc cggtcgatgt aacatcaccg
     8881 tttttaactt accaatttct gaataaacat gaatcggact cgacattcaa ccaccttcta
     8941 ttaattattg tacccgttta catttattat ggatcaatta ggtaaaagtt acagtattat
     9001 catattgcag caatgatttt tttcattaaa ggtgtaactt gatgatcttt acgccaaacc
     9061 agctgcaaat gtgttatcca attagcatgt ttaattgcga tcatattttc ttgggcataa
     9121 gttgtcgcaa ttgattctgg tactagcgct actcccattt ttctcttggc ccaagtaatt
     9181 gctgtccgtg aatcatcaca cttaaccgca taaaatggtt taagcccatg atgtgcaaaa
     9241 gtttgattaa aaatatcctc aaagcgacga taaataatca atggctgatc tgctagatct
     9301 ttaatgcgta attctttttt ttgctgaaaa tctgggtcta cactaatagc catcattttt
     9361 tcagttgtta aagtcttagt atttaaacct gtctggttgt aaggcgttcg tacaatgcct
     9421 agatcgattg tctttttttc taatttatcc aggatgccat aagtattatc ttcataaata
     9481 tcaaaagaaa tttccggata atattttcgt aattcattaa aagaattcat tggtatcaag
     9541 cccgttgagg aagatgccat tccaattgca atcgttccca attcaccgga aatagtctta
     9601 tgtacttggt tttcagcatt ttgagctaga gaaataattt cattggcata gctttgaaaa
     9661 atttgtccca catcagttag ctcaatacca tgtgccgttc ttttaaataa ttgcgcgccc
     9721 aactctttct ctaattgttt taattgatag cttaatggtg gctgtgcaat atacaagcgc
     9781 ttagcagctg ctgtaatctg cttttcttct gctacaacta gaaaataacg taactgtttt
     9841 agattcatat tatttatcct ttttttattt caattgatag tgatattaaa atatttaata
     9901 tcttatattg tattttagta ttttattcat agcaatatct gtgctacctt attaaggtag
     9961 atttggaggg aaaataatgt ctgataaatt tcacggctta actcaagccg aagcagacaa
    10021 gcgcttaaaa gaagatggct taaatgaagt accagagcct gaatacaatt tctttaaaga
    10081 gttcttgtct aagttatgga acctatccgc ttggattcta gaagctgctt taattctaga
    10141 atgtatcttg ggcaaatggg tccaatcatt attcgtgttg ttgatgcttt tatttgctgc
    10201 atttaacggt gcatctaaga aaaagcaatc aagacgagtt ttaaataata tttcacacaa
    10261 gttgactcct actgtatcag ttgaacgcga tggcaagtgg atcaaacttg attctaaaca
    10321 actagttaaa ggcgatttaa tctcacttaa acgcggggac gtactcgcag cagatgttaa
    10381 aattgttgac ggtaacttag cttgtgatga aagctcaatt acaggtgaat ctaaaccagt
    10441 taagaaagca attgatgaca ccgcctttgc cggtactaca gttgttgaag gtgatggcct
    10501 agctgttgtt actgctacag gtaaagattc tagaagcggt aagacgatta atttgatcaa
    10561 caattccgct gctcctggtc acttacaaca acttttgact aagattatct actacctttg
    10621 cttactagat ggtgttttaa ccttagttat tattatcgcc tccttcttca aaggcggtaa
    10681 tttcaatacc tttattaata tgttgccatt cctggcaatg atgtttattg cttcaattcc
    10741 tgtagcaatg ccatcaactt ttgctttatc caactcattt gaagcaaccc gcttaagtaa
    10801 agaaggagtc ctgacttctg acctaactgg aattcaggac gcagctaact tgaacttgct
    10861 tttacttgat aagactggaa caattacgga aaacaaaact gccgtagccg cttggactga
    10921 tctaagtgac ttgcctgaca aagacgtgct tgctttagct ggagccgcaa ctgataaacg
    10981 taatgctggt attatcgata cagcaatcga tgaatactta gtagaaaata acattccagt
    11041 catgaatgct gaaaacttta ctccatttac ttctgacact ggttattcta tggctgatgt
    11101 tgctggacat aatgtaaagc ttggttcatt taagcaatta tctttgatcg ataaacatgc
    11161 cgatgaagaa atttctggaa ttaatttcaa ggcaggacgc tcagtggcag tcttgattga
    11221 cgataagtta gctggtgtct tcatcttaca agataaagtt agaacagact ctaaagcagc
    11281 tttggctgaa ctcaagaaac gtggcgttcg cccaattatg ttaactggtg acaatcaaaa
    11341 gaccgctgct gcagtggcag aacaagttga tttaactggt aaagtaattt cgattcacga
    11401 tttcaatgaa aatactgata ttaatgattt ggccggtatt gctgatgttt taccagaaga
    11461 taaactcaag atggtaaagc ttttccaaga aaaaggctat atcgtaggga tgacaggtga
    11521 cggagttaac gacgcgcctg cattaaaaca agctgaagta ggaatcgcag tttcaaatgc
    11581 tgctgacgta gctaagcgtt cgggtaaaat ggtattacta gacgatggtc taggctcaat
    11641 tgttaaaatt ttagacgctg gacatcgcgt ataccaaaga atgactactt ggtcactaac
    11701 caagcttgct agaactgctg aattaacgat gctgttaact tttggctatc ttttctttga
    11761 ctacatccca atggccttga atgcaatggt tatctatacc attatgaaca atatggttac
    11821 gatgatgatt ggaactgaca ggactcacat tacttataag ccagaaaact ggaatatggc
    11881 taagcttgct aagatcgcct tttcactagc tgctggttgg actttaattg gtattgggtt
    11941 tgtttggttc ttaaacacac acggttggag tcacggtgct gtttctacta tggtttacgt
    12001 atacctagtt cttagcgcaa tgttgattgt tttgattact agaactcgta agtacttttg
    12061 gcaagattac ccatccaagt tggttggtag tgttcaaatt gcagatgttc tattgacctt
    12121 tatcttagct ctttgtggtt gggcaatggt ccagatttcc attcaaaact tagcaattac
    12181 tgtaattgta gcgattattg ctgccataat aatcgactta atttaccaac ctgtgatgaa
    12241 aaacaggtag attattacca taaattttat aaattaaaag acttctagga actttgaact
    12301 cttagaagtc ttttaattta tctttttgat tcacgatatc ctgctgcacg tgctgctgct
    12361 ttactcttga agaaaactgc attttcacga ttcattcgat aattatgacc gcgcattacg
    12421 tgaaagattt ttgatcgttt attatcaaca attctgtaat tactggtata aatcttagtt
    12481 ttatcacgat attgatgctt tctccttctg tgatgaatag ctgcattaac aactgatgtc
    12541 gacccctgca aatttgcagg cagaacactg atttctccca ctaacatcag aaatgcaaca
    12601 atagtcacaa cccaattctt gcatcttttc ataaaaacac tcccttaata tgtcactata
    12661 tttatatagt atacgtttat atatgaagtg ttcctacgtt tattagaaac tagtttgaaa
    12721 ctgtcaaatc ttttgtgtaa atagttcttt ctcgtaaatt gattttttaa ttatttattt
    12781 aatcaaagta ggattctaag gtgtcctgaa cctgaccaaa gcctttatga attcgattga
    12841 a
//
