LOCUS       c00026_JAFEHM0..        5364 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAFEHM010000027.1 Lacticaseibacillus paracasei strain 2306
            NODE_27_length_30501_cov_32.218279, whole genome shotgun sequence.
ACCESSION   JAFEHM010000027
VERSION     JAFEHM010000027
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-19 22:16:30
            Original ID  :: JAFEHM010000027.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 5364
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..5364
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[130:364](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(131..364)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..5364
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..5364
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(3..80)
                     /locus_tag="ctg26_1"
                     /transl_table=11
                     /translation="MHYCGIINPLELAVFLHFPCIFWEPT"
     CDS             complement(131..364)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg26_2"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 4e-15, bitscore:
                     47.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYNYRQLDDFQLSGVSGGKKKFDCAATFVTGITAGIGSGTITGL
                     AGGPFGIIGGAVVGGNLGAVGSAIKCLGDGMQ"
     CDS             complement(636..1589)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039:aldo/keto reductase family oxidoreductase (Score:
                     223.7; E-value: 5.1e-68)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg26_3"
                     /transl_table=11
                     /translation="MKQVRLGGSNWQASSVALGIMRMNVLAPDKAANVLDSAYNDGINF
                     IDSADIYGQGKSEEVFGEALKQASVSRDQLFIQSKVGIVVDPKRSHGSLVFGKRYDFSK
                     DHLLSAVDHILKRLQVDYLDSVLLHRPDPLMEVDDVAAAFDALEQSGKVRHFGVSNFNP
                     EQIALLESGIRQPLLIDQVQFSVAHTGMVNAGMHTNMADAASVDHDGSLLPYLQRKHMT
                     LQAWSPFQYGMFEGTFIDSPKFKALNDELQKVADHYHTNKNAIAVAWLLRHPVGVQVIL
                     GSMNPEHIKESAEGADITLTRQEWYDIYFAAGNDLP"
     CDS             1794..2528
                     /NRPS_PKS="Domain: PKS_KR (6-169). E-value: 4.6e-12. Score:
                     38.0. Matches aSDomain: nrpspksdomains_ctg26_4_PKS_KR.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     192.7; E-value: 1.3e-58)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg26_4"
                     /sec_met_domain="adh_short (E-value: 5.7e-35, bitscore:
                     112.2, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LTVKDKVVVITGASSGIGAATVQVLAEAGAKLVIGARRTERLAEL
                     AASFTNGQVLYQQTDVTDQQQVKALIDLALDKFGHVDVLYNNAGLMPLSEMAELKVNEW
                     ERMIDVNIKGVLYGIAAVLPPMIAQHSGQIITTDSVAGHIVHPGTAVYSGTKWAIQAIM
                     DGLRQEQAANHIKTTMISPGAVNTELFSTITDPKRREAVEADEKNNGLSASDVAKAVLY
                     AIDQPANVAINEVLLRPVTQER"
     aSDomain        1812..2300
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg26_4_PKS_KR.1"
                     /evalue="4.60E-12"
                     /label="ctg26_4_PKS_KR.1"
                     /locus_tag="ctg26_4"
                     /protein_end="169"
                     /protein_start="6"
                     /score="38.0"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVVITGASSGIGAATVQVLAEAGAKLVIGARRTERLAELAASFTN
                     GQVLYQQTDVTDQQQVKALIDLALDKFGHVDVLYNNAGLMPLSEMAELKVNEWERMIDV
                     NIKGVLYGIAAVLPPMIAQHSGQIITTDSVAGHIVHPGTAVYSGTKWAIQAIMDGLRQE
                     "
     aSModule        1812..2300
                     /domains="nrpspksdomains_ctg26_4_PKS_KR.1"
                     /incomplete
                     /locus_tags="ctg26_4"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       1815..1895
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg26_4_0001"
                     /evalue="1.90E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg26_4"
                     /protein_end="34"
                     /protein_start="7"
                     /score="14.1"
                     /tool="antismash"
                     /translation="VVITGASSGIGAATVQVLAEAGAKLVI"
     CDS             2479..3717
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217:NADH:flavin oxidoreductase/NADH oxidase (Score:
                     291; E-value: 1.9e-88)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg26_5"
                     /transl_table=11
                     /translation="MLPSMKCSYGQSRKNVNFRLKECDCMSGYHFLKPFTFKHQTITLK
                     NRIVIPPMTTRLSFEDGTVTRDEIRYYQQRAGGVGMFITGTANVNALGKGFEGELSVAD
                     DRFIPGLSKLAAAMKTGGTKAILQIFSAGRMSNSKILRGEQPVSASAVAAPRAGYETPR
                     ALTSAEIEATIHDFGQAVRRAILAGFDGIELHGANTYLIQQFYSPNSNRRTDEWGGDRD
                     KRMRFPLAVVHEAEKVIATIADRPFLLGYRISPEELEQPGITLDDTLALIDTLKQTKID
                     YLHVSQSDVWRTSLRNPEDTAIMNEQIRDHVAGAFPVIVVGGIKTPADAEKAAESFDLV
                     AIGHEMIREPHWVQKVLDHDEKAIRYQIAPADLEELGIAPTFLDFIESISGGAKGVPLT
                     TAQSVTSSNVTQD"
     CDS             complement(3979..5355)
                     /locus_tag="ctg26_6"
                     /transl_table=11
                     /translation="MSKYRTETDTLGPVEIPANALWGPQTERSRHNFQAGPLMPMPVIR
                     ALLQLKKAAARANVAADVLPAPKGQLITRAVDALLALPDEKLQKDFPLHVYQTGSGTQT
                     NMNVNEVISHQAAKLNPDLPILPNDDVNHSQSSNDTFPTVMNITAAIAVNQLLHAVNQL
                     CSVLYSKAVTYARVVKIGRTHLQDATPLTFGQEISGWVAMMEHDQIALKQLQPNLFYLA
                     IGGTAVGTGLNADPNFGKIVAGRLSDVYQLPLSAKTNKFAALAAHSEISVVHGAIKTLA
                     ADLLKIANDIRFLASGPRAGYGELRIPANEPGSSIMPGKVNPTQAEALTMAAVRVMGND
                     TTITVAASQGNFELNVYKPVIISTFLESADLLTKTVTSFTEKLAAGLTIHAPHMRALVD
                     HSLMLVTALAPHIGYEKSAAIAQLAEQENLDLKAAAIKSGDVTAAQFDKWVDPLKMTRA
                     "
ORIGIN
        1 cgagtaggtt cccaaaaaat gcaaggaaaa tgcaggaaaa cagctaattc caatggattt
       61 attataccgc aataatgcat atattagctt aactgcctga attatagaat ttttaagcag
      121 ccactactta tcattgcatc ccatctccta agcatttaat agctgaccca accgctccta
      181 agtttccacc aactacggcg ccgccgatta tcccaaaagg accaccagct aggccagtaa
      241 tcgttcctga tccaatacca gccgtgatgc cagtaacaaa tgtagcagca caatcaaatt
      301 tctttttccc acctgaaacc cctgacaact gaaaatcgtc gagctggcga taattataag
      361 acataatttt ccttttttct tcaaaaagca acaagttatt ttgtgtaagg tcgattttac
      421 tgtctttaac atacattaat tatttgtgta aaatgccaaa attttttaaa ggtaggaaat
      481 ttccagttta acgtcgtctt tacactttta ttgttcagtt gcgctttaaa agtcaaaaat
      541 tcttaacgtt taaatctcct tgcttggtaa aaacttcaat tttttgcaaa aaaaatcgtc
      601 tcagcaattt gagacaattt tttcatatca tcaacttacg gcaagtcatt ccccgccgca
      661 aagtaaatgt cataccattc ctgtcgggtc aacgtgatgt ccgcgccttc cgcactttcc
      721 ttgatatgtt caggattcat agagccgaga atcacttgca caccgactgg atggcgtaat
      781 agccaagcga ctgcgattgc atttttattg gtatggtagt ggtcagcgac tttctgcagt
      841 tcatcattca acgccttaaa tttcgggcta tcgatgaagg taccttcaaa catgccgtat
      901 tggaatggcg accaggcttg taaggtcatg tgtttgcgtt gcaagtatgg tagcaggctg
      961 ccgtcatgat cgacagaagc cgcgtcggcc atgttggtgt gcatccccgc attgaccata
     1021 ccagtgtgcg caacggagaa ctgaacttgg tcgatcagca aaggctgccg aatgccgctt
     1081 tcaagcaacg caatttgttc agggttaaag ttggagacac caaaatgccg aaccttgccg
     1141 ctttgttcca atgcatcaaa ggccgccgca acgtcatcga cttccattaa cggatctggc
     1201 cggtgcagca agaccgaatc aaggtaatca acctgcaacc gtttcaaaat gtgatcaacc
     1261 gctgacagta agtgatcttt tgaaaagtcg taccgtttgc cgaataccaa actgccatga
     1321 gagcgttttg gatcaacgac gatcccgact ttcgattgaa tgaataactg atcgcgggaa
     1381 acgctggctt gcttcaaggc ttcaccaaaa acttcttcgg atttgccttg gccataaatg
     1441 tcggccgagt cgataaagtt gatgccgtca ttgtacgcac tatccagcac attggccgct
     1501 ttgtcggggg ccagcacatt catccgcatg atgcccaagg ccacacttga cgcctgccaa
     1561 ttggatccgc ctaatcgaac ttgtttcata aacacaaaac tcccttcgat acgtcatttc
     1621 aaattatgtt actgacgaca agttaagtgt agcccctaaa gtccacttga ggtcaagcca
     1681 atattagaat ttcaataaaa cagcttgcat ggtgctgagc tgcgcggtag gttaagctgt
     1741 gtctgttact tattttttct tagcaggata agcccataaa ggaggccgtg attttgacag
     1801 ttaaagataa agtggttgta atcacaggtg catcgagcgg gattggcgcg gcaacggtac
     1861 aagtgttggc cgaggctggt gcaaaactag tcatcggtgc gcggcgcaca gaacggttgg
     1921 ctgaattggc ggccagcttt acgaacggtc aggtgctgta tcaacaaacc gatgtgaccg
     1981 accagcagca agtgaaagcg ctgattgatt tggcgttgga taagtttggt catgtggatg
     2041 ttttgtataa caacgctggc ctgatgccac tttctgaaat ggccgaactc aaagtcaacg
     2101 aatgggaacg tatgattgac gtcaacatta aaggcgtctt gtatgggatc gccgcggttt
     2161 taccgcctat gattgcccaa cacagtggcc aaattatcac aacagactca gttgccggtc
     2221 acattgttca ccctggaacc gccgtttact ccggtaccaa gtgggctatc caggcgatca
     2281 tggacggcct gcgacaagaa caagcggcta atcatattaa aacgaccatg atctcgcccg
     2341 gtgccgtgaa tactgagctt ttcagcacaa ttaccgatcc taagcgccgt gaagctgttg
     2401 aagccgatga aaaaaacaat ggcctcagcg cctcggatgt tgccaaggca gttttgtatg
     2461 ccattgatca accggccaat gttgccatca atgaagtgct cttacggcca gtcacgcaag
     2521 aacgttaatt ttcgtctaaa ggagtgtgat tgcatgtcgg gttatcattt tttaaaaccg
     2581 ttcaccttca agcaccaaac catcacgttg aaaaatcgca ttgtcattcc gccgatgaca
     2641 acgcgcctgt cgtttgaaga cggcactgtg acgcgggacg aaatcaggta ttaccagcaa
     2701 cgggccggtg gcgtcggcat gtttattacc ggtaccgcca acgtcaatgc gcttggcaaa
     2761 ggattcgaag gtgagctaag tgtcgctgat gatcgattca tccccggttt gagcaaactc
     2821 gccgctgcga tgaaaacagg cggcaccaag gctattttgc aaatcttcag cgctggccgc
     2881 atgagcaata gcaagattct gcgcggtgag cagccagtca gtgccagtgc ggttgctgcg
     2941 ccacgggcgg gttacgaaac accgcgcgca ttgacatcgg cagaaatcga ggccactatt
     3001 cacgattttg gtcaggctgt gcgccgcgcc atccttgctg gttttgatgg catcgaactg
     3061 catggtgcca acacctatct gatacagcaa ttctattcgc caaactctaa tcgccgaacc
     3121 gatgaatggg gcggtgaccg cgataagcgg atgcgttttc cgttggcagt cgttcatgaa
     3181 gcagaaaaag tgattgccac aattgctgac cggccatttt tgttaggcta ccgcatttcg
     3241 ccggaagagt tggaacagcc tggcattacc ttggatgata ccttggcctt aatcgacact
     3301 ttgaaacaaa ccaagattga ttacttgcac gtctcccaaa gtgacgtttg gcgaacctca
     3361 ttgcgcaacc ccgaggacac agccatcatg aatgaacaaa ttcgtgacca tgtcgccggt
     3421 gcttttccag tgattgtggt cggtggcatt aaaacccccg ccgatgctga gaaagcggca
     3481 gaatcctttg atttggtcgc gattggtcac gaaatgattc gcgagccgca ctgggttcag
     3541 aaggtcttag accatgacga aaaggcgatc cgttaccaga tcgcccctgc tgatcttgaa
     3601 gaacttggca ttgcgccgac cttcctcgat tttatcgaaa gtatttccgg tggggcaaaa
     3661 ggtgtcccgt taacaactgc gcagtctgtg acatcaagca acgtgactca agattaatct
     3721 agcatttcaa atcatcgtgc gagtcgagct gtaaaaagct cggctttttt cttgccgtct
     3781 tcaacttacg cgctggtgcc tgaagctacc agtgatttat aagttttaaa tcaaggtgtg
     3841 atcatcacct gctcacgctc tgacttaaac gcgttcgctg gcgcagctcg gctatgcgaa
     3901 ggacagtgac acagatggtc caaagcccag accatctgtg tcactgccac ttcgctacgc
     3961 cgagctaacc acgccagctc acgctcttgt catttttaac gggtcgaccc atttatcaaa
     4021 ctgcgctgct gtgacgtcgc cgcttttgat ggcggctgct tttaaatcga ggttttcttg
     4081 ctcagccaat tgcgcgatgg cggcactttt ttcgtagccg atgtggggtg cgagggcggt
     4141 gaccagcatg agcgaatgat caacgagtgc tctcatatgc ggtgcgtgga tggtcaagcc
     4201 ggcagctaat ttttcagtga aactcgtgac tgttttggtt agtagatcag ctgactctaa
     4261 aaaggtactg atgataaccg gcttgtagac gttcaattca aaattgcctt gtgacgcggc
     4321 caccgtgatc gtcgtatcgt tgcccatgac tcgaacagcg gccatggtta gcgcttcggc
     4381 ctgtgtggga ttcactttgc ccggcatgat ggaactacca ggctcattgg ccggaatgcg
     4441 caactcgccg tatccagcac gtggaccact ggcaaggaag cgaatgtcat tggcgatttt
     4501 aagcagatcc gccgctagcg ttttaatggc accatgaaca acgctaattt ctgagtgtgc
     4561 cgctaaagca gcaaacttat tggttttcgc cgaaagtggt aattgataaa catcgctcaa
     4621 tcggcccgcc acaatcttgc caaaattagg gtcagcgtta agccccgttc cgactgctgt
     4681 tccgccaatg gctaagtaaa aaagattggg ctgaagctgc tttaaagcaa tctgatcatg
     4741 ctccatcatg gccacccatc cgctgatttc ttggccaaac gttagcggcg ttgcatcctg
     4801 taaatgagtt cgaccgattt taacaacacg agcgtaagtg acggcttttg aatataaaac
     4861 actgcacagt tggttgacag cgtgcaacaa ctgattcact gcaatagccg ccgtaatatt
     4921 catcacagtt ggaaaagtat cattggagct ttgactgtga ttcacatcat cattcggtaa
     4981 gatcggcaag tcggggttga gttttgcagc ttggtggcta atgacttcgt tcacattcat
     5041 atttgtttgt gtgccagacc cggtttgata gacatgcagt ggaaaatctt tttgcagttt
     5101 ttcgtctggc aaggccaaca aggcatcgac tgctcgcgtg attaattggc cttttggtgc
     5161 cggtaaaaca tcagcggcca catttgctcg cgctgccgct tttttgagtt gcagcaaggc
     5221 cctaatcact ggcatcggca tcaatggacc agcctgaaaa ttatggcggc tgcgctctgt
     5281 ttgcggtccc cacaaagcgt ttgccggaat ttcaactggt cctaatgtgt ccgtttctgt
     5341 tcgatatttg ctcatgttta cctc
//
