LOCUS       c00037_JAFEHM0..       13184 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAFEHM010000037.1 Lacticaseibacillus paracasei strain 2306
            NODE_37_length_13184_cov_23.780501, whole genome shotgun sequence.
ACCESSION   JAFEHM010000037
VERSION     JAFEHM010000037
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2022-06-21 01:36:31
            Original ID  :: JAFEHM010000037.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13184
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13184
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1792:7494]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1793..7494
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..13184
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13184
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             complement(112..288)
                     /locus_tag="ctg37_1"
                     /transl_table=11
                     /translation="MDSSNNKLFKFMNNHLMGPMGKLASFRIVRGVMAAGMASIPFTIV
                     GSMFLIINVPRLQ"
     CDS             complement(311..805)
                     /locus_tag="ctg37_2"
                     /transl_table=11
                     /translation="MSDQNKARYDKSRRELSLTSMYFNRYLLIRYVTAGFFFANLYWFF
                     LSLGTQGAMKWVPFCLTVINAVVAVEQVSKYWRRDSKLPFTKFGYVVQLISNFLSLSII
                     VAGSGTKLFPFLGQKGLSLATTVLLIGLGICFYLLVRIRLIEKNQDRYLQQINKFAQSI
                     Q"
     CDS             complement(832..1149)
                     /locus_tag="ctg37_3"
                     /transl_table=11
                     /translation="MNEQEQLVIMQLIMAGGNAKGSSFEAIKAAKVGDFSTAEAKLKEA
                     DSFLSDAHNAQTGMLTEEAQGKKHPVSLLMVHGQDHVMNAITFRDLAGEIVDLYKKLAT
                     K"
     CDS             complement(1159..1473)
                     /locus_tag="ctg37_4"
                     /transl_table=11
                     /translation="MGKKTIMLVCAAGMSTSMLVKKMEDAATKDGIEAKIFATSASDAH
                     DKLDSEKPDVLMLGPQVRYLEGDFKKDLSIPVQVINMQDYGLMKGENVLKTALKLIDEQ
                     "
     CDS             complement(1793..3547)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg37_5"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.1e-39, bitscore:
                     123.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEKINAADAMIKVLEDWGIHNIYGLPGGSFDSTMNALYNRRHTI
                     NYVQVRHEEVGALAAAGEAKVTGRIGATFGSAGPGAVHLLNGLYDAQYDNVPVLALVGQ
                     VPTAAMNTNYFQEMNENPMFADVSVYNRTAMTAEQLPHVVDEAIRQAYKHNGVAVVTIP
                     KDLGWTQIDDNYVSSANLYQKPLLPDPDPDQVAAAWDILKDAKKPILYVGNGARGARDE
                     IIAFSEKTHIPIITTALAKGIVPDDYKANMGSAGRVASKPGVEVARGADTVLFLGSDFP
                     FQPYFIAPNAKYIQVDIDGSKFGRRHTVDLAVLADAKKFIKALSEKADQLPESAWYRAA
                     LANKENWREWMTSFEDDGSTPLRVEPIFKLINEMAEKDAIFQVDVGNVTINGMRYLKTN
                     DDQVFTTSGWYATMGYALPAAIGAQAEFPDRQVWSISGDGGFAMVMQDILTQVKYHMPI
                     INVVLTNESLGFIEAEQDDTQQPHSGVDLIDADYGKATEALGAQGFEVHNLDELKAAFA
                     KAKDRKGPVVIDVKISDLRPIPVEQLVLDKQTQDPAAVDAFVKKYHAESLIPFRQLLED
                     AEKPVTNA"
     CDS             complement(3871..5037)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ACP_syn_III"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg37_6"
                     /sec_met_domain="ACP_syn_III (E-value: 1.6e-09, bitscore:
                     27.5, seeds: 136, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIGIDAIAMDTPDFYVDLVKLAQVRGDDPDKYTIGIGQDEQAVP
                     PSSQDIVTMGANAATKLLTPAIRASLGMVLVGTESGVDASKSAALFIHDLLALPEWVRA
                     VELKEACYGGTAALMMARDYIAAHPDKTVLVIAADIARYGLATAGEVTQGAGAVAMLIK
                     AEPHIMTIEDDSVYRSESIADFWRPVYQDTAIAQGKYSTEQYLAFFQAIWSRYQTQRHH
                     TASDFAAMTFHLPYTKMGKKALKLVLPDTDEATGERLQRRFEASTRYCRRVGNIYTGSL
                     YLGLLSLLDNDTSLKAGDRIGLFSYGSGAVAEFFSGILQPDFAAQLHAANHAKMLADRQ
                     ELTVPEYEAVFSDKVPYDPEDYRSDPTYYHGQFVLTGVIGQERQYQQR"
     CDS             complement(5021..6301)
                     /locus_tag="ctg37_7"
                     /transl_table=11
                     /translation="MKFYELSPEKRRDQLVQEGWLTTQDAALLAGTHSLPEVTGARLIE
                     NAIGEFPLPLGVARNLLVNGQLHQVPIADEEPSVIAAASNGARLATANGGVRTHVAAHR
                     VVAEVVLTNLTDLVQARQTILAHQTDIQKVIAVAHPSMIQRGGGLDQLTVESLGAQFLK
                     IRLTLDPQQAMGANYANTVAEAVAAAVTSWVDGDVLVSILTNAPTELVTAEVSLEPVSL
                     ATKAVSGDVIAKKIVQLSDLAFVDAERAVTHNKGILNGIIGAVLATGNDTRAVAASIGA
                     FACASGRYQPLSRWYMDQGHLVGHLQLPLPMGAVGGAIGALPMAQVVRRLGGYQNLAIM
                     QQVIAALGLVQNLAAMRALAGPGIQAGHMKLQANALAIAAGATETELPMLVNALRQGSM
                     DLKHAQQYLTTIRLNKKVGQSKDENRD"
     CDS             complement(6313..7494)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: Thiolase_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: Thiolase_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg37_8"
                     /sec_met_domain="Thiolase_N (E-value: 3.2e-94, bitscore:
                     304.9, seeds: 30, tool: rule-based-clusters)"
                     /sec_met_domain="Thiolase_C (E-value: 3.1e-44, bitscore:
                     139.5, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEEVVILSAKRTPIGKLGGDLVGASAVDLGVAAAQAAIKAARIDP
                     ALLNQAIFGNVMQAGSGQNVARQIGLKSGMATSSTAMTVNEVCGSGLKAVRLGQAAIQL
                     GEADAVLVGGTESMSQVPYYAEAVRSGHKFGDTTLVDGLSRDGLNDAFSQQPMGITAEN
                     VATQFNVSRQEQDEFALRSHLRAAAAAAEGRFKSQIAPVTIAARHGDVIVDRDSAIRPD
                     TSLAKLAQLPPVFEVGGTVTAGNASGINDGAAALILMAKSKAEQLGLHYLATITGFAEV
                     GIDPAIMGYAPKLAIDKILQATGGSIAAIDQIELNEAFASQSVAVARDLGLKDEQFNIN
                     GGALALGHPLGASGARILISLLYDLAERNQRQGIAALCVGGGIGIAMQIAMHV"
     CDS             7839..8138
                     /locus_tag="ctg37_9"
                     /transl_table=11
                     /translation="MRVTDLLALLADQNKNASVLLDTKPTPSRFDDFKLTTVNDQPQLV
                     FQPNPERKAALRVWELQLLLNQPDLQQRFVYLADVDEPRALFGFVKRQIGLLLN"
     CDS             complement(8139..8969)
                     /locus_tag="ctg37_10"
                     /transl_table=11
                     /translation="MLLGLKASTDERQIRDRLQYHPDVFEFHLTENDFTEAGWSHFVQM
                     AALVQSQVPTVVFHHPMRFRGQRNELAMNPTKYPTRYDFLMTSSVKLMNFAKKANATAL
                     IHGGYRVDTPGDYAGWTDVGKAQDVALARMIAFAQEAPGHVVFENSMSPIFRYGDPTFE
                     DRLLRWHLPLAYDTSHTFIVLHGDNDRLMASLAHLKPLIRHYHLVDSMGQTHDSLPLGR
                     GRIDWARVLPLLNQNASRIYEIGLKDQFDCREMIESHHYLESVAKRLAATKHPA"
     CDS             complement(9117..9734)
                     /locus_tag="ctg37_11"
                     /transl_table=11
                     /translation="MQLRGESARLKGKERGRPMRTLLKKAYQLLWGLFILALAYSIWAR
                     SFLPRQLRQYGDPASFGIISLFVVINAIMLYHHHFRFRDLKMETVDIMEGEKFESFCAY
                     LLKRNGFNHIQLTQASGDQGIDIIARKKGKTIGFQCKRYTGFVGNKAVQEVWAGHHFYQ
                     LDEAAVITNSEFSDSAIALADDLGVMLIDRKKLKRLMRRLPS"
     CDS             9793..10611
                     /locus_tag="ctg37_12"
                     /transl_table=11
                     /translation="MQLSAKIFAKVGSERITQYSLVNDHQMTLRFLTFGARVQQVRLPN
                     AAGDDPNLLLGFVTLEDYLHQPGYLGAFTGPLQAADAELAPGSWQNWNWAVKTSQETDL
                     AITFTLTLPENADGQPGQRALSITHRLTNDNLWQIDMQVATTADLKIHPRLNLPWMLTA
                     DPAQTMLSAKLTADEHVTPVPKTARCETVQRYSLAAADWQLAYLSDASFTRIDSYAGIN
                     SENNFNGILGQPNVAVGFSPEMNQDALPWVLPAGATWRHHAEFHLSSNAN"
     CDS             complement(10671..11810)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M20"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg37_13"
                     /sec_met_domain="Peptidase_M20 (E-value: 9.7e-37, bitscore:
                     116.5, seeds: 360, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LTEEEQVVDLLSAMVKIPSVAAKEGQVADLIETFLAPELKAGLIK
                     RERISYAPGRDNLVLTIGNPNAQRWLGVDGHMDVVDPGNVNKWQFPPFSAHVEDGKLYG
                     RGATDMKSGLAAAVVAFKQAAHEKLDHGIQLMATVGEEVDNDGARQLSAAGYGDRLTGL
                     LVAEPGNSNVDAAERGIIDYTLTAHGKAAHSSRPDLGANAIHGLFAFANAALTATAPLQ
                     AKEDPILGHATHNIDIIHGGNQINSIPESAYLRGNIRTTMIADNDAFIAALKQAAKTTV
                     PKGVRLSLSIDSVLGAAAASPDNDLIQLVQTARQRAGLNRGQVAYRTGITDAALFYHDG
                     LDLAIYGPGNETSHETDEYVTLKDVFDSVKVFKDVFMNY"
     CDS             complement(11889..12494)
                     /locus_tag="ctg37_14"
                     /transl_table=11
                     /translation="MTQRGKAYNIAIIGILGALIILQAYIPMVGYVQIFPAWPAISTIH
                     LTVIIGGIVLGYGGGASLGLLWGLTSLIRAYTSATDPVTLLLFRNPIIAIVPRVMVGLV
                     AAFIFHQLFKKKQTPLAQTVKMVFAGVVGALTNTLLVIGFTWLMFASKAAQIVPGADAT
                     NLGWLLMTALAINAVAEALLGGIVTPILGHALLRFRRK"
ORIGIN
        1 gaccgatatt caacaagcca cagcgcttat caataacaaa cctagaaaat gtctccgttg
       61 gcaaacccca gttcaagcag tgagcaagcc tctttctagg tggtaacttt attattgcaa
      121 tctaggaaca ttaataatta aaaacattga tccaacgatg gtaaatggaa tggatgccat
      181 tccggcagcc atgactccgc gaacgattct gaacgaggca agttttccca ttggtcccat
      241 caaatgattg ttcataaatt taaacaattt attattactt gaatccatag ttttgtctcc
      301 ttgtttgagc tcattgtatg ctttgagcaa atttatttat ttgttgtaaa taccgatcct
      361 gatttttttc aatcaaacgg atacgcacta agagataaaa acatatgcct agaccaatta
      421 acagaacagt cgttgccaga gataaaccct tttgtcctaa aaatggaaac agttttgtcc
      481 cagatccagc gacaattatg gataagctca ggaaattgct tattaactga actacataac
      541 cgaacttagt aaatggtaac ttgctatctc ttcgccagta cttacttact tgttcaaccg
      601 ctaccactgc atttataacg gtcaaacaaa acggtaccca tttcatcgcg ccctgtgtgc
      661 ccaaactaag aaaaaaccaa tataaatttg caaagaaaaa accggcggtc acgtaacgga
      721 ttaataaata gcgattaaag tacatactag ttaagcttaa ttctctccga ctcttgtcat
      781 atcttgcttt attttggtct gacatgcgtg tcacattcct ttcgcttaga cttatttcgt
      841 agctaacttt ttatagaggt caacgatttc ccctgctaag tctcgaaatg tgattgcatt
      901 cataacatga tcctgtccgt gcaccatcaa taatgatact ggatgttttt tcccttgagc
      961 ttcttcggtt aacatacctg tttgtgcatt atgtgcatct gacagaaagc tgtctgcctc
     1021 tttcagtttt gcttctgcgg tagaaaaatc accgactttt gcagctttaa ttgcctcaaa
     1081 agaagatcct tttgcatttc ctccggccat aattagctgc atgatcacta gttgctcttg
     1141 ctcgttcatc ctgacctcct actgctcgtc aatcagctta agagccgttt ttagaacatt
     1201 ttcgcctttc attaagccgt aatcctgcat attgatcact tgaactggga tactaagatc
     1261 ctttttgaaa tctccctcta aataacgcac ttgtggtcca agcatcagga catctggttt
     1321 ttctgaatct aacttgtcat gggcatctga agccgaagta gcaaagattt ttgcttcaat
     1381 accatctttg gtcgctgcat cttccatttt tttgactaac atactggttg acatacctgc
     1441 tgcacaaact aacataattg tcttcttacc cattagtttt tcctcgcttt caaaatttca
     1501 aagttattgt tcaccacaga atgacttttt aatatcagca tactcgctag cttaacgagc
     1561 catatcagaa gtcattcgaa tgactattcg ttcgaacgac ttttataata ccaagaaatc
     1621 gctttcttgt aaacgatttc tttaattttt taaaattttg tctctacgcc ttatcgcaaa
     1681 agcccggcaa ctaataatga agacttaaaa tagcggtaag caaaaaaaaa gccttccagc
     1741 aaggcatatt aattgctgga aagctttgta atttatattt taagtcaacc agttaagcat
     1801 ttgttaccgg tttctccgca tcttccagta actgtcggaa tggaatcaga ctttctgcat
     1861 gatatttctt cacaaaagca tccacagcag caggatcctg agtttgcttg tccaaaacaa
     1921 gttgttcaac cggaattggc cgaagatcag aaatcttcac atcaatgaca accggaccct
     1981 tacgatcttt tgccttagca aatgcggctt tcaattcgtc cagattgtgc acttcaaatc
     2041 cttgagcacc taacgcttca gttgccttac cataatcagc atcaattaaa tcaaccccgg
     2101 agtgcggctg ttgcgtgtca tcctgttcag cttcaataaa gcctaaactc tcattcgtca
     2161 aaacaacgtt gatgattggc atatgatatt tgacctgtgt cagaatatcc tgcatgacca
     2221 tggcaaatcc accatcacca gaaattgacc aaacttgccg atcagggaat tccgcttgcg
     2281 caccaatcgc tgctggcaag gcataaccca ttgtcgcata ccagccagac gtcgtgaaca
     2341 cttgatcatc attggtcttc agataacgca tcccattgat ggtaacattg ccaacgtcta
     2401 cttggaaaat ggcatctttt tcggccatct cattgatcaa tttgaagatt ggttcaacgc
     2461 gcagtggcgt ggagccatca tcttcaaatg aagtcatcca ctcgcgccaa ttttccttgt
     2521 tggccagagc agcccgatac caagcgcttt ctggcaattg atcagccttt tcgctcagtg
     2581 ccttgatgaa cttcttagca tcggccaaaa cagctaagtc aaccgtgtga cgacggccaa
     2641 acttgctacc gtcaatatca acctgaatgt atttagcatt tggtgctata aagtatggct
     2701 ggaatgggaa atccgatccc aagaacaaga cggtgtcagc accgcgcgca acttcaacgc
     2761 caggtttaga agccacacgg ccggccgagc ccatgtttgc cttataatca tcaggcacga
     2821 ttcccttagc caaggcagtc gtgatgatcg gaatatgcgt tttttctgag aaagcgatga
     2881 tctcgtcgcg cgcaccccgc gcgccatttc caacatacaa gattggcttc ttcgcatctt
     2941 tcaagatatc ccaagctgcg gcaacctgat ccgggtctgg gtcaggcaaa agcggcttct
     3001 ggtacagatt ggctgatgat acataattgt catcaatctg ggtccaacct aaatcctttg
     3061 gaatagtcac aacggcaacc ccgttatgct tataagcctg acgaatcgcc tcgtcaacaa
     3121 catgaggcaa ttgctcagca gtcatggctg tacggttgta tacagacaca tcagcaaaca
     3181 ttgggttctc gttcatttct tggaaataat tggtgttcat ggcagcagtt ggtacttgcc
     3241 ctaccaatgc caaaactggc acattatcat actgtgcgtc atacaaccca ttcagaagat
     3301 gaacagcacc aggaccggca gaaccaaacg tcgccccgat tcgacccgtt accttagctt
     3361 cacctgcagc agccaatgcg cctacttctt catggcgaac ctgaacataa ttaatggtgt
     3421 gacggcgatt gtacagcgca ttcatggtac tatcaaaaga accgcccggt aacccataaa
     3481 tattatggat accccagtct tcgagcacct tgatcattgc gtctgcggcg tttatttttt
     3541 ctgtcatgac acttgcctcc aatattatta cttacatttt gtaagttctt tacgattacg
     3601 agtataacaa tttattgata acaatgcaag ccctttcatc tggtttaagc aaccttaacg
     3661 cccaaattgc gaccttagcg tataaaacgc ttgaactagc aagcgacgac accataacag
     3721 tcaaacaagt gaactaatac agcatcacca cgccataaca tgcttggtaa atctttttca
     3781 caaattaact taatgatgat caggatcatg gatcaaaaaa aaggaccgtc gagggacggt
     3841 ccttttcatc atcttattag ctgtcaagca ttaccgctgc tgatattgac gttcttgacc
     3901 gatcacaccg gtcaaaacaa actgaccgtg ataataagtc ggatcactac gataatcttc
     3961 tggatcataa ggcaccttat cgctgaaaac agcttcgtat tcaggaacgg ttaattcctg
     4021 acgatcagcc aacattttag cgtgattggc tgcatgcagt tgtgcggcaa aatccggttg
     4081 caagatgccg ctaaaaaatt ctgccacagc cccggagcca tacgagaata aaccgatccg
     4141 gtcacccgct ttcaagctag tatcattgtc caacaacgac agcagaccca aatacaaaga
     4201 accggtataa atattgccaa ctcgccggca gtaccgagtg cttgcctcaa agcgccgttg
     4261 cagtcgctcg ccagtggctt catctgtgtc cggcagaaca agctttaaag ctttcttgcc
     4321 cattttggta tacggtaaat ggaatgtcat cgcagcaaaa tcacttgctg tgtgatggcg
     4381 ttgggtctgg tatcgtgacc aaattgcttg aaaaaaagct aaatattgtt ccgttgaata
     4441 ctttccttgt gcaattgctg tgtcttgata aaccggccgc caaaaatcgg caatagattc
     4501 agaccgataa accgaatcgt cttcaatggt catgatgtgc ggctctgctt tgattaacat
     4561 ggcaaccgcg cccgcacctt gtgtgacttc tcctgctgtt gccaaaccgt accgggcgat
     4621 atccgcagca atgactaaaa cggttttatc tgggtgagcg gcgatgtagt cacgcgccat
     4681 cattagtgcg gcagtaccgc cataacaagc ttcctttaac tcaacggccc gcacccactc
     4741 agggagtgcc aataaatcat gaataaacaa tgcagccgat ttactggcat caacaccact
     4801 ttcagtacca accaagacca tgcccaagct agcgcgaatc gctggcgtca acaactttgt
     4861 cgctgcattc gcacccatcg tgacaatgtc ttggctagaa ggtggtaccg cttgctcgtc
     4921 ttggccaatg ccaatcgtat atttgtccgg atcatcacct cgaacctgcg cgagttttac
     4981 taaatcaacg tagaaatctg gggtgtccat agcgattgca tcaatcccga ttttcatctt
     5041 ttgattggcc tactttcttg tttaaacgaa tggttgttaa atattgttgc gcatgtttta
     5101 aatccatact accttgacga agtgcgttca caagcatcgg caattctgtt tctgttgccc
     5161 cggcagcaat ggcgagggca ttagcttgca acttcatgtg accagcttga atccccggtc
     5221 cagccaatgc tcgcatcgca gcaagatttt gcaccaaccc gagggcggca ataacttgct
     5281 gcatgatagc taaattctga tacccaccga gccgacggac aacctgcgcc attggtaaag
     5341 caccgatcgc cccgccaact gcccccatcg gcaagggcag ctgtaagtga ccaactaaat
     5401 ggccctgatc catataccag cgcgataaag gctgatacct gccagacgca catgcaaatg
     5461 caccgatact tgctgcgaca gcgcgggtat cattgccagt agccaataca gcaccaataa
     5521 taccgttaag aatgcccttg ttgtgggtca ctgcccgctc agcatcgaca aaggctaaat
     5581 cgctaagctg aacaattttc ttagcaatca catctccaga aacagctttc gtcgctaaag
     5641 aaaccggctc aagcgaaacc tcagccgtca cgagttctgt tggcgcgttg gttagaatac
     5701 tgacaagcac atcaccgtct acccagcttg tcaccgccgc tgcgaccgct tcggcaactg
     5761 tattcgcata attggccccc attgcctgtt gcggatcgag cgttaaacgg attttcaaga
     5821 actgcgctcc tagtgattcg actgttaact gatcaagacc accgccacgt tgaatcatcg
     5881 aaggatgcgc aaccgcaatg actttctgaa tatcagtctg atgagccaaa atcgtttgcc
     5941 ttgcttgcac taagtcggtc aagttagtca ggactacttc agcgaccact cgatgcgccg
     6001 ctacatgggt cctaacgccg ccgtttgcag tcgcaagcct ggccccatta ctggcagctg
     6061 caatcacaga aggttcctca tccgctatag gcacttgatg tagctgtcca ttgaccaaca
     6121 aattgcgagc aacgcctagg ggtaaaggaa actcgccgat ggcattttcg atcagacgcg
     6181 ctcctgtgac ttcaggcaag ctatgcgtac cagctaacaa cgcagcatcc tgtgttgtta
     6241 accacccttc ttgaaccaat tgatcacggc gtttttccgg agacaactcg taaaatttca
     6301 tcacgatctc cctcagacat gcatcgcgat ttgcatggcg ataccgatgc caccgccaac
     6361 gcacaatgcg gcaatacctt ggcgttgatt acgttcagcc agatcgtaca ataatgagat
     6421 taaaattcga gcgcctgaag ctcccaatgg atgccccaac gctaaggcgc caccattgat
     6481 attgaattgt tcatccttta aaccaaggtc acgagccaca gcaacgcttt gtgaggcaaa
     6541 tgcttcattc aattcaattt gatcaattgc cgcgatagag ccgccggttg cctgcagtat
     6601 tttatcgatc gccagttttg gcgcataccc cataattgcc ggatcaatac ccacctcggc
     6661 aaaaccagtg atcgtcgcta aataatggag ccccagttgt tcggctttcg attttgccat
     6721 caggatcaag gcggctgcgc catcattaat gccgcttgcg ttacctgctg taacagtacc
     6781 gccgacttca aaaacaggcg gtaattgggc taatttagcc aatgacgtat cgggccgaat
     6841 ggctgaatca cgatctacga tgacatcccc gtgacgggca gcaatcgtca ctggggcgat
     6901 ctgactctta aaccgaccct cagctgcggc ggccgcggcg cgtaaatgcg aacggagagc
     6961 aaactcatct tgctcctgac gactgacgtt aaattgtgtc gccacatttt ccgccgtgat
     7021 tcccattggc tgctgactga aggcatcatt taatccatcg cgactcaaac cgtcaaccag
     7081 cgttgtatcg ccaaatttgt ggcctgaacg aaccgcttcg gcgtaataag gtacttgact
     7141 catgctttcg gtaccgccca cgagcaccgc gtcagcctcg ccgagttgaa tggcagcttg
     7201 cccaagccgc actgccttca ggcctgagcc acagacttca ttgacagtca tcgccgtgct
     7261 gctagtggcc ataccgcttt ttaatccgat ttgtcgggca acattctgcc cagaaccagc
     7321 ctgcatgaca ttaccaaaga tcgcctggtt gagtaacgct gggtcaattc gtgcagcctt
     7381 aatcgccgcc tgcgctgccg caacccctaa atcaacggca ctggcgccaa ccaaatcacc
     7441 acccaactta ccaatcggcg tccgtttagc acttagaatc acaacttctt ccatgatgac
     7501 ctcctaaaga gcgtgaacag ccaaccggcg cataatcaag aacgagggca atggccgagc
     7561 cattgttctc gtggttctga tgtgccggtt tctgtggcta tgaacgcgtt tcgacaagca
     7621 tatgctgaga taaaccgttt cagtttatca cagtcgttca gatgacgcac tgatataata
     7681 agagcgtgag ccaacccggt tacaccgact tttgggttgg cgatcgccta agaacgctac
     7741 tcatctccgt taactaaata gattgtatgc gattgttccc caaagcaaca accatcttga
     7801 ccaatcctta atgaatcatt tcgaaagaag gctacctcat gcgtgtcacc gatttgctgg
     7861 ctttactagc cgatcaaaat aaaaacgcct cggtgttact cgacacaaag ccgacaccaa
     7921 gtcgtttcga cgattttaag ttaacaaccg ttaatgatca accgcaactg gtctttcagc
     7981 ctaatcctga gcgcaaagcc gcattgcgcg tttgggaatt gcaactctta ctgaaccaac
     8041 ctgatttaca gcaacgattc gtttatctag ctgatgttga tgaaccgcgt gcgttatttg
     8101 gatttgttaa acggcaaatt ggcttgctgc tcaattgatt acgctggatg tttggtcgca
     8161 gctaaccgtt tagcaacgct ttccaaataa tgatgacttt caatcatttc ccgacaatca
     8221 aactgatcct ttaaaccaat ttcataaatg cgactcgcat tttgattcaa cagtggcaag
     8281 acccgcgccc aatcaatccg tccgcggcca agcggtaaac tatcatgcgt ttgccccatg
     8341 gaatcaacaa gatgatagtg ccgaatcagt ggcttcagat gcgctaggct ggccatgagc
     8401 cgatcattat cgccatgtaa cacaataaac gtatgactgg tatcataggc taaaggtaaa
     8461 tgccagcgca acaaacggtc ttcaaaggtg ggatccccat atcggaaaat cggtgacatg
     8521 gaattttcaa acacgacatg gcccggtgct tcctgggcaa aagcaatcat gcgcgccaag
     8581 gcaacgtctt gtgctttgcc cacatctgtc cagccagcat aatcaccagg cgtgtcaacg
     8641 cggtatccgc cgtgaatcaa agccgtggcg ttagcttttt tggcaaagtt catgagttta
     8701 accgaacttg tcattaaaaa gtcatagcgt gtaggatact tcgtcggatt catggcaagc
     8761 tcattgcgct ggccgcgaaa ccgcatcgga tgatgaaaaa ccaccgttgg cacctgactc
     8821 tgaactaatg ctgccatctg tacaaaatgc gaccatccag cttcggtaaa atcattttcg
     8881 gtgagatgaa attcgaatac atcaggatga tattgcagcc gatcacgaat ctgccgctca
     8941 tctgtactag cctttaagcc taatagcatg tacacttttc ctccttaatt caaaacccgc
     9001 tcatgatccc aaaaattgct cataagaacg ttaagcatcg ctgaccaagg ctctaagcag
     9061 cttctgctcc gatttcgaag cgctcctact tgcactttca aatttcagtt gtctttttaa
     9121 cttggcaacc ggcgcattaa acgtttcaat tttttacgat caatcagcat cacacccaag
     9181 tcgtcggcca aggcgatcgc cgaatcagaa aattcgctat tggtgatcac cgccgcttcg
     9241 tcgagctggt aaaaatgatg gcccgcccaa acttcctgca cggccttgtt gccaacgaaa
     9301 ccggtgtaac gcttgcactg aaagccaatc gttttacctt ttttgcgggc aataatatca
     9361 attccttgat cacctgaagc ctgcgtcagt tgaatgtgat taaacccatt gcgcttcaac
     9421 agatacgcgc aaaaagactc aaacttttca ccctccatga tatcgacagt ttccattttc
     9481 aaatcacgaa aacgaaaatg atgatgataa agcatgatgg cattgatcac aacaaaaaga
     9541 ctgatgatcc caaaactagc cggatcacca tattgccgca gttggcgggg cagaaaactg
     9601 cgggcccaaa tgctgtaagc gagtgccaaa ataaagagcc cccacaacag ctgataggct
     9661 tttttgagta acgttctcat gggtctaccc ctctctttcc ctttaagcct agcagattca
     9721 ccgcgtaatt gcattgaatc tctgccaatt tttctgtacg cttaagggat tgagagagga
     9781 agcgttttcg tcatgcaact aagtgccaag atctttgcca aagtcggtag tgaacggatt
     9841 acccagtatt ctttagtcaa tgaccatcag atgacgctac gttttttaac gtttggtgct
     9901 cgggttcaac aggttcgcct gccaaatgct gcaggtgacg atcctaatct gctgctcggg
     9961 ttcgtcacgc tggaagacta cttacaccaa cccggttacc taggcgcctt taccggccct
    10021 ttacaggcag ctgacgctga gctagccccg ggttcatggc aaaactggaa ttgggcggtt
    10081 aaaaccagtc aagaaaccga tctagccatc accttcaccc taacattacc tgaaaatgct
    10141 gacggtcagc caggccagcg agcactcagt attacccacc gattgacaaa tgacaatttg
    10201 tggcagattg acatgcaggt ggcaaccact gccgacttga aaatacatcc ccggctcaat
    10261 ttgccttgga tgctcactgc cgaccctgcc caaacaatgc tttcagccaa gttgactgcc
    10321 gatgaacatg ttacccctgt ccctaaaact gcccgctgtg agactgtgca acgctattcc
    10381 cttgcagccg ccgattggca gttggcatat ctaagcgatg cttcattcac gagaattgat
    10441 tcttacgctg gcatcaactc cgaaaataat tttaacggta ttctcggcca acccaatgta
    10501 gcagtcggct tttcgccgga aatgaaccaa gacgctctgc cgtgggtgtt gccagccggt
    10561 gcaacttggc ggcatcatgc ggaatttcac ttatctagca acgcaaacta aaaaggtttg
    10621 accccacggt atctgttgtg tggtcaaacc ttttttccaa tcagtgatga ttaatagttc
    10681 ataaaaacat ccttgaagac tttaacactg tcaaagacgt cttttaaagt gacgtattca
    10741 tccgtctcat gagacgtttc atttcccggg ccataaatag ctaaatcaag accgtcatga
    10801 tagaacaacg ccgcatccgt gatgccggtg cgataggcca cttgaccacg attcagcccc
    10861 gcacgttgac gggctgtctg taccaactga atcaaatcat tatcaggtga agccgcagct
    10921 gcccctaaaa cggaatcaat tgacagactc aaccgaacac ccttaggcac tgtcgtttta
    10981 gctgcttgtt tcaacgccgc aataaacgca tcattatccg caatcatggt tgtccggatg
    11041 ttaccgcgca aatatgcgga ctccggaatc gagttgatct gattgccacc atggataata
    11101 tcaatattat gcgtggcatg accaagaatg gggtcctctt ttgcctgcaa cggcgctgtt
    11161 gcagttagcg ctgcattcgc aaatgcaaac aacccatgaa tggcatttgc ccctaaatct
    11221 ggccgagacg aatgtgctgc tttcccgtgc gcggtcaatg tgtaatcaat aataccgcgt
    11281 tcagcagcgt caacattgct attgccgggt tcagccacaa gcagtccagt taaacgatct
    11341 ccgtaaccgg cagcagacag ttggcgtgcg ccgtcattat caacttcttc accaactgtc
    11401 gccatcaatt gaatcccatg atccaatttt tcatgagcag cttgcttgaa tgccacaacc
    11461 gctgcagcca gtccagactt catgtcagtt gcaccacgac cgtacaactt gccatcttct
    11521 acatgtgctg agaatggtgg aaactgccat ttattgacgt tcccagggtc aaccacatcc
    11581 atatggccat ccacaccgag ccagcgctgg gcattaggat taccgatcgt cagcaccaaa
    11641 ttatcacgac cgggcgcata actgatgcgt tcccgtttaa tcaatccggc tttcaactca
    11701 ggggctaaaa aggtttcaat caggtctgct acctgacctt cttttgctgc cacacttggt
    11761 atctttacca tggcactgag taaatcaacg acttgttctt cttctgtcaa gataaggcct
    11821 ccgcttatga tcgtttgtat gctgcttttg tttggcttcg gacagccgct cagcacaaca
    11881 tttaacgctt atttccgtct gaatcgtaat aatgcatgac ccaaaatcgg cgttacgata
    11941 ccgcccaaca aggcctcggc tacggcgtta atcgccaaag ccgtcatcaa taaccatcct
    12001 aggttggtcg catccgcacc cggcacaatt tgcgctgctt tactggcaaa catcaaccat
    12061 gtaaacccaa tgaccagcaa ggtgttcgtc aaagcaccga caacaccggc gaaaaccatt
    12121 ttaactgttt gcgccaacgg tgtttgtttt ttcttgaaca attgatgaaa aataaatgcc
    12181 gccactaaac caaccatgac acgcggcacg atggcgataa tcggatttct aaacagcagc
    12241 agggtcactg gatcagtcgc tgatgtatac gcccgaatca gactggttaa cccccataat
    12301 aagccaaggc tggcaccgcc gccatagcct aatacaatac caccaatgat gacagtcaaa
    12361 tgaatcgttg aaatcgcagg ccaagccgga aaaatctgca catatccgac cattggaata
    12421 taagcctgaa gaataatcaa agcaccaaga ataccaataa tcgcaatatt ataagctttt
    12481 ccgcgttgcg tcatgcgctg ctacctccaa attgtctaag tttgatttta tcaaattata
    12541 cacgttcgag gaaagtgatg ctgggaggaa gacttttacc ggaaacgcta gggaaaaggt
    12601 tggctgtcaa agaattcccg cgatggtgtt gcacaaaaca cgctcgtatt tggaggagac
    12661 tacacataaa gacctcataa ataaatgact gaaaaccggt cattgactta tccgccggtt
    12721 tctaaacgcg ttcgccaccc cagaaacctg cgtgtaagga ccttgatcgc aatggccaaa
    12781 cccaggccat cacggtcaag ttcgcttaca ctccggtttc taaccggggt ggcgaacgct
    12841 cttgaaaaat aaagtttgac tttaaatccc taatttccta taatatttct tgtgcttaat
    12901 tagccatgcg ggcatggcgg aattggtaga cgcgcaagat taaggatctt gtgagcatta
    12961 ttgctcatgg aagttcgagt cttcttgccc gcatcacaaa agacccgacc aacaggacat
    13021 cttgttggtc gggtcttttt tgctacctta gattttcggc tctacgtcaa ctggtgttga
    13081 agaataaatt tatcatttga ggcggttctc catttggaga gccgtctttg tcatgttatg
    13141 ccgtgatttg gtagattcgt ttgaagaagt tcagctgatt cttg
//
